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Sample records for modeling section ends

  1. Water Quality Modeling in the Dead End Sections of Drinking ...

    Science.gov (United States)

    Dead-end sections of drinking water distribution networks are known to be problematic zones in terms of water quality degradation. Extended residence time due to water stagnation leads to rapid reduction of disinfectant residuals allowing the regrowth of microbial pathogens. Water quality models developed so far apply spatial aggregation and temporal averaging techniques for hydraulic parameters by assigning hourly averaged water demands to the main nodes of the network. Although this practice has generally resulted in minimal loss of accuracy for the predicted disinfectant concentrations in main water transmission lines, this is not the case for the peripheries of a distribution network. This study proposes a new approach for simulating disinfectant residuals in dead end pipes while accounting for both spatial and temporal variability in hydraulic and transport parameters. A stochastic demand generator was developed to represent residential water pulses based on a non-homogenous Poisson process. Dispersive solute transport was considered using highly dynamic dispersion rates. A genetic algorithm was used to calibrate the axial hydraulic profile of the dead-end pipe based on the different demand shares of the withdrawal nodes. A parametric sensitivity analysis was done to assess the model performance under variation of different simulation parameters. A group of Monte-Carlo ensembles was carried out to investigate the influence of spatial and temporal variations

  2. Water quality modeling in the dead end sections of drinking water distribution networks.

    Science.gov (United States)

    Abokifa, Ahmed A; Yang, Y Jeffrey; Lo, Cynthia S; Biswas, Pratim

    2016-02-01

    Dead-end sections of drinking water distribution networks are known to be problematic zones in terms of water quality degradation. Extended residence time due to water stagnation leads to rapid reduction of disinfectant residuals allowing the regrowth of microbial pathogens. Water quality models developed so far apply spatial aggregation and temporal averaging techniques for hydraulic parameters by assigning hourly averaged water demands to the main nodes of the network. Although this practice has generally resulted in minimal loss of accuracy for the predicted disinfectant concentrations in main water transmission lines, this is not the case for the peripheries of the distribution network. This study proposes a new approach for simulating disinfectant residuals in dead end pipes while accounting for both spatial and temporal variability in hydraulic and transport parameters. A stochastic demand generator was developed to represent residential water pulses based on a non-homogenous Poisson process. Dispersive solute transport was considered using highly dynamic dispersion rates. A genetic algorithm was used to calibrate the axial hydraulic profile of the dead-end pipe based on the different demand shares of the withdrawal nodes. A parametric sensitivity analysis was done to assess the model performance under variation of different simulation parameters. A group of Monte-Carlo ensembles was carried out to investigate the influence of spatial and temporal variations in flow demands on the simulation accuracy. A set of three correction factors were analytically derived to adjust residence time, dispersion rate and wall demand to overcome simulation error caused by spatial aggregation approximation. The current model results show better agreement with field-measured concentrations of conservative fluoride tracer and free chlorine disinfectant than the simulations of recent advection dispersion reaction models published in the literature. Accuracy of the simulated

  3. Water quality modeling in the dead end sections of drinking water (Supplement)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Dead-end sections of drinking water distribution networks are known to be problematic zones in terms of water quality degradation. Extended residence time due to...

  4. End-to-End Neural Segmental Models for Speech Recognition

    Science.gov (United States)

    Tang, Hao; Lu, Liang; Kong, Lingpeng; Gimpel, Kevin; Livescu, Karen; Dyer, Chris; Smith, Noah A.; Renals, Steve

    2017-12-01

    Segmental models are an alternative to frame-based models for sequence prediction, where hypothesized path weights are based on entire segment scores rather than a single frame at a time. Neural segmental models are segmental models that use neural network-based weight functions. Neural segmental models have achieved competitive results for speech recognition, and their end-to-end training has been explored in several studies. In this work, we review neural segmental models, which can be viewed as consisting of a neural network-based acoustic encoder and a finite-state transducer decoder. We study end-to-end segmental models with different weight functions, including ones based on frame-level neural classifiers and on segmental recurrent neural networks. We study how reducing the search space size impacts performance under different weight functions. We also compare several loss functions for end-to-end training. Finally, we explore training approaches, including multi-stage vs. end-to-end training and multitask training that combines segmental and frame-level losses.

  5. Model Manipulation for End-User Modelers

    DEFF Research Database (Denmark)

    Acretoaie, Vlad

    End-user modelers are domain experts who create and use models as part of their work. They are typically not Software Engineers, and have little or no programming and meta-modeling experience. However, using model manipulation languages developed in the context of Model-Driven Engineering often...... of these proposals. To achieve its first goal, the thesis presents the findings of a Systematic Mapping Study showing that human factors topics are scarcely and relatively poorly addressed in model transformation research. Motivated by these findings, the thesis explores the requirements of end-user modelers......, and transformations using their modeling notation and editor of choice. The VM* languages are implemented via a single execution engine, the VM* Runtime, built on top of the Henshin graph-based transformation engine. This approach combines the benefits of flexibility, maturity, and formality. To simplify model editor...

  6. Model outputs - Developing end-to-end models of the Gulf of California

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project is to develop spatially discrete end-to-end models of the northern Gulf of California, linking oceanography, biogeochemistry, food web...

  7. Atlantis model outputs - Developing end-to-end models of the California Current Large Marine Ecosystem

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project is to develop spatially discrete end-to-end models of the California Current LME, linking oceanography, biogeochemistry, food web...

  8. Optimized capture section for a muon accelerator front end

    Directory of Open Access Journals (Sweden)

    Hisham Kamal Sayed

    2014-07-01

    Full Text Available In a muon accelerator complex, a target is bombarded by a multi-MW proton beam to produce pions, which decay into the muons which are thereafter bunched, cooled, and accelerated. The front end of the complex captures those pions, then manipulates their phase space, and that of the muons into which they decay, to maximize the number of muons within the acceptance of the downstream systems. The secondary pion beam produced at the target is captured by a high field target solenoid that tapers down to a constant field throughout the rest of the front end. In this study we enhance the useful muon flux by introducing a new design of the longitudinal profile of the solenoid field at, and downstream of, the target. We find that the useful muon flux exiting the front end is larger when the field at the target is higher, the distance over which the field tapers down is shorter, and the field at the end of the taper is higher. We describe how the solenoid field profile impacts the transverse and longitudinal phase space of the beam and thereby leads to these dependencies.

  9. Front-end conceptual platform modeling

    DEFF Research Database (Denmark)

    Guðlaugsson, Tómas Vignir; Ravn, Poul Martin; Mortensen, Niels Henrik

    2014-01-01

    Platform thinking has been the subject of investigation and deployment in many projects in both academia and industry. Most contributions involve the restructuring of product programs, and only a few support front-end development of a new platform in parallel with technology development. This con......Platform thinking has been the subject of investigation and deployment in many projects in both academia and industry. Most contributions involve the restructuring of product programs, and only a few support front-end development of a new platform in parallel with technology development....... The conclusion is that the Conceptual Product Platform model supports stakeholders in achieving an overview of the development tasks and communicating these across multidisciplinary development teams, as well as making decisions on the contents of the platform and providing a link between technical solutions...

  10. Physical oceanography - Developing end-to-end models of the California Current Large Marine Ecosystem

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project is to develop spatially discrete end-to-end models of the California Current LME, linking oceanography, biogeochemistry, food web...

  11. Towards an energy end use model

    International Nuclear Information System (INIS)

    Smith Fontana, Raul

    2003-01-01

    The general equilibrium energy end use model proposed, uses linear programming as te basic and central element to optimization of variables defined in the economic and energy areas of the country related to a four factors structure: Energy, Raw Material, Capital and Labor, and related to the sectors: Residential, Commercial, Industrial, Transportation and Import/Export. Input-Output coefficients are defined in an input-output matrix of processes representing the supply of Electricity (generated by nuclear- not available in Chile-hydro, gas, fuel-oil and coal), Petroleum, Imported Natural Gas (transported and distributed) National Natural Gas, LPG, Coal, Wood and representing a demand of Residential, Commercial, Industrial, Transportation and Import/Export. There is an interaction of the final demand composition, the prices of capital, labor and taxes with the levels of operation for each process and the prices of goods and services. In addition to the prices of fuels for each annual period, to the supply and demand of energy and to the total demand it can forecast the optimum coefficients of the final demand. If the data to be collected result reasonably complete and consistent, the model will be useful for planning. A special effort should be placed in specifying a certain number of typical energy activities, the available options for fuels, the selection of them attending rational market decisions and conservation according to well known economical criteria of substitution. To simulate the process of options selection given by the activities and to allow substitutions, it is possible to introduce the logit function characterized by a Weibull distribution and the generalized substitution function characterized by the constant electricity. The model would allow, assuming differents scenario, to visualize general policies in the penetration of energy technologies. To study the penetration of electric energy generated by nuclear, in which the country does not have

  12. Definition of the Face Profile in the End Section of the Teeth of the Thread Milling Cutters with Helical Flutes

    Directory of Open Access Journals (Sweden)

    O. V. Malkov

    2014-01-01

    Full Text Available An increasing thread accuracy in details of the machine-building production results from the improved design and manufacturing stages of threading tools. In modern industry, thread milling cutters gain an increasingly greater spread for thread manufacturing. Preliminary studies have shown that improving the accuracy of a cut thread is closely connected with the task of profiling the teeth of the thread milling cutters with helical flutes, and the accuracy of the solution depends on the face profile of the tool into the end section. In addition, the face profile of the tool is required to solve problems related to the calculation of strength thread milling cutters and evaluation of geometrical parameters of the teeth.The analysis of GOST 1336-77 on thread milling cutters showed that there are no geometric and structural parameters characterizing the end thread milling cutters with helical flutes. Since the standard presents thread milling cutters with a straight flutes, in which the shape of the tooth profile cutters of the second order is the same as in normal and end sections, for cutters with helical flutes it is necessary to solve the problem of conversion of normal and end sections to get the desired shape of the cutting edge.In order to assess the face profile, the end mills of high speed steel and carbide have been analyzed to show that the vast majority of the face profile of the tooth is specified in the normal section line, which is taken as an input in determining the function of the profile form for the face of the end section of the teeth thread milling cutter with helical flutes.The paper solves the problem of calculating the coordinates of the profile of the endsection of a tooth cutters with helical flutes adopted at the original tooth profile in normal section. It has been verified by modeling software CATIA V5 R17. An example illustrates finding the function form of the end section. Calculations have shown that in the end

  13. End-to-End Delay Model for Train Messaging over Public Land Mobile Networks

    Directory of Open Access Journals (Sweden)

    Franco Mazzenga

    2017-11-01

    Full Text Available Modern train control systems rely on a dedicated radio network for train to ground communications. A number of possible alternatives have been analysed to adopt the European Rail Traffic Management System/European Train Control System (ERTMS/ETCS control system on local/regional lines to improve transport capacity. Among them, a communication system based on public networks (cellular&satellite provides an interesting, effective and alternative solution to proprietary and expensive radio networks. To analyse performance of this solution, it is necessary to model the end-to-end delay and message loss to fully characterize the message transfer process from train to ground and vice versa. Starting from the results of a railway test campaign over a 300 km railway line for a cumulative 12,000 traveled km in 21 days, in this paper, we derive a statistical model for the end-to-end delay required for delivering messages. In particular, we propose a two states model allowing for reproducing the main behavioral characteristics of the end-to-end delay as observed experimentally. Model formulation has been derived after deep analysis of the recorded experimental data. When it is applied to model a realistic scenario, it allows for explicitly accounting for radio coverage characteristics, the received power level, the handover points along the line and for the serving radio technology. As an example, the proposed model is used to generate the end-to-end delay profile in a realistic scenario.

  14. End-to-end modeling as part of an integrated research program in the Bering Sea

    Science.gov (United States)

    Punt, André E.; Ortiz, Ivonne; Aydin, Kerim Y.; Hunt, George L.; Wiese, Francis K.

    2016-12-01

    Traditionally, the advice provided to fishery managers has focused on the trade-offs between short- and long-term yields, and between future resource size and expected future catches. The harvest control rules that are used to provide management advice consequently relate catches to stock biomass levels expressed relative to reference biomass levels. There are, however, additional trade-offs. Ecosystem-based fisheries management (EBFM) aims to consider fish and fisheries in their ecological context, taking into account physical, biological, economic, and social factors. However, making EBFM operational remains challenging. It is generally recognized that end-to-end modeling should be a key part of implementing EBFM, along with harvest control rules that use information in addition to estimates of stock biomass to provide recommendations for management actions. Here we outline the process for selecting among alternative management strategies in an ecosystem context and summarize a Field-integrated End-To-End modeling program, or FETE, intended to implement this process as part of the Bering Sea Project. A key aspect of this project was that, from the start, the FETE included a management strategy evaluation component to compare management strategies. Effective use of end-to-end modeling requires that the models developed for a system are indeed integrated across climate drivers, lower trophic levels, fish population dynamics, and fisheries and their management. We summarize the steps taken by the program managers to promote integration of modeling efforts by multiple investigators and highlight the lessons learned during the project that can be used to guide future use and design of end-to-end models.

  15. Integrated Ray Tracing Model for End-to-end Performance Verification of Amon-Ra Instrument

    Science.gov (United States)

    Lee, Jae-Min; Park, Won Hyun; Ham, Sun-Jeong, Yi, Hyun-Su; Yoon, Jee Yeon; Kim, Sug-Whan; Choi, Ki-Hyuk; Kim, Zeen Chul; Lockwood, Mike

    2007-03-01

    The international EARTHSHINE mission is to measure 1% anomaly of the Earth global albedo and total solar irradiance using Amon-Ra instrument around Lagrange point 1. We developed a new ray tracing based integrated end-to-end simulation tool that overcomes the shortcomings of the existing end-to-end performance simulation techniques. We then studied the in-orbit radiometric performance of the breadboard Amon-Ra visible channel optical system. The TSI variation and the Earth albedo anomaly, reported elsewhere, were used as the key input variables in the simulation. The output flux at the instrument focal plane confirms that the integrated ray tracing based end-to-end science simulation delivers the correct level of incident power to the Amon-Ra instrument well within the required measurement error budget of better than ±0.28%. Using the global angular distribution model (ADM), the incident flux is then used to estimate the Earth global albedo and the TSI variation, confirming the validity of the primary science cases at the L1 halo orbit. These results imply that the integrated end-to-end ray tracing technique, reported here, can serve as an effective and powerful building block of the on-line science analysis tool in support of the international EARTHSHINE mission currently being developed.

  16. Clamped end conditions and cross section deformation in the finite element absolute nodal coordinate formulation

    International Nuclear Information System (INIS)

    Hussein, Bassam A.; Weed, David; Shabana, Ahmed A.

    2009-01-01

    In the finite element absolute nodal coordinate formulation (ANCF), the elimination of the relative translations and rotations at a point does not necessarily define a fully clamped joint, particularly in the case of fully parameterized ANCF finite elements that allow for the deformation of the cross section. In this investigation, the formulations and results of two different sets of clamped end conditions that define two different joints are compared. The first joint, called the partially clamped joint, eliminates only the translations and rotations at a point on the cross section. The second joint, called the fully clamped joint, eliminates all the translation, rotation and deformation degrees of freedom at a point on the cross section. The kinematic equations that define the partially and fully clamped joints are developed, and the dynamic equations used in the comparative numerical study presented in this paper are shown. As discussed in this investigation, the fully clamped joint does not allow for the deformation of the cross section at the joint node since the gradient vectors remain orthogonal unit vectors. The partially clamped joint, on the other hand, allows for the deformation of the cross section. Nanson's formula is used as a measure of the deformation of the cross section in the case of the partially clamped joint. A very flexible pendulum that has a rigid body attached to its free end is used to compare the results of the partially and fully clamped joints. The numerical results obtained using this very flexible pendulum example show that, while the type of joint (partially or fully clamped) does not significantly affect the gross reference motion of the system, there are fundamental differences between the two joints since the partially clamped joint allows for the cross section deformations at the joint node

  17. Modelling end-glacial earthquakes at Olkiluoto

    International Nuclear Information System (INIS)

    Faelth, B.; Hoekmark, H.

    2011-02-01

    The objective of this study is to obtain estimates of the possible effects that post-glacial seismic events in three verified deformation zones (BFZ100, BFZ021/099 and BFZ214) at the Olkiluoto site may have on nearby fractures in terms of induced fracture shear displacement. The study is carried out by use of large-scale models analysed dynamically with the three dimensional distinct element code 3DEC. Earthquakes are simulated in a schematic way; large planar discontinuities representing earthquake faults are surrounded by a number of smaller discontinuities which represent rock fractures in which shear displacements potentially could be induced by the effects of the slipping fault. Initial stresses, based on best estimates of the present-day in situ stresses and on state-of-the-art calculations of glacially-induced stresses, are applied. The fault rupture is then initiated at a pre-defined hypocentre and programmed to propagate outward along the fault plane with a specified rupture velocity until it is arrested at the boundary of the prescribed rupture area. Fault geometries, fracture orientations, in situ stress model and material property parameter values are based on data obtained from the Olkiluoto site investigations. Glacially-induced stresses are obtained from state-of-the-art ice-crust/mantle finite element analyses. The response of the surrounding smaller discontinuities, i.e. the induced fracture shear displacement, is the main output from the simulations

  18. End-to-end modeling: a new modular and flexible approach

    Science.gov (United States)

    Genoni, M.; Riva, M.; Landoni, M.; Pariani, G.

    2016-08-01

    In this paper we present an innovative philosophy to develop the End-to-End model for astronomical observation projects, i.e. the architecture which allows physical modeling of the whole system from the light source to the reduced data. This alternative philosophy foresees the development of the physical model of the different modules, which compose the entire End-to-End system, directly during the project design phase. This approach is strongly characterized by modularity and flexibility; these aspects will be of relevant importance in the next generation astronomical observation projects like E-ELT (European Extremely Large Telescope) because of the high complexity and long-time design and development. With this approach it will be possible to keep the whole system and its different modules efficiently under control during every project phase and to exploit a reliable tool at a system engineering level to evaluate the effects on the final performance both of the main parameters and of different instrument architectures and technologies. This philosophy will be important to allow scientific community to perform in advance simulations and tests on the scientific drivers. This will translate in a continuous feedback to the (system) design process with a resulting improvement in the effectively achievable scientific goals and consistent tool for efficiently planning observation proposals and programs. We present the application case for this End-to-End modeling technique, which is the high resolution spectrograph at the E-ELT (E-ELT HIRES). In particular we present the definition of the system modular architecture, describing the interface parameters of the modules.

  19. Screening California Current fishery management scenarios using the Atlantis end-to-end ecosystem model

    Science.gov (United States)

    Kaplan, Isaac C.; Horne, Peter J.; Levin, Phillip S.

    2012-09-01

    End-to-end marine ecosystem models link climate and oceanography to the food web and human activities. These models can be used as forecasting tools, to strategically evaluate management options and to support ecosystem-based management. Here we report the results of such forecasts in the California Current, using an Atlantis end-to-end model. We worked collaboratively with fishery managers at NOAA’s regional offices and staff at the National Marine Sanctuaries (NMS) to explore the impact of fishery policies on management objectives at different spatial scales, from single Marine Sanctuaries to the entire Northern California Current. In addition to examining Status Quo management, we explored the consequences of several gear switching and spatial management scenarios. Of the scenarios that involved large scale management changes, no single scenario maximized all performance metrics. Any policy choice would involve trade-offs between stakeholder groups and policy goals. For example, a coast-wide 25% gear shift from trawl to pot or longline appeared to be one possible compromise between an increase in spatial management (which sacrificed revenue) and scenarios such as the one consolidating bottom impacts to deeper areas (which did not perform substantially differently from Status Quo). Judged on a coast-wide scale, most of the scenarios that involved minor or local management changes (e.g. within Monterey Bay NMS only) yielded results similar to Status Quo. When impacts did occur in these cases, they often involved local interactions that were difficult to predict a priori based solely on fishing patterns. However, judged on the local scale, deviation from Status Quo did emerge, particularly for metrics related to stationary species or variables (i.e. habitat and local metrics of landed value or bycatch). We also found that isolated management actions within Monterey Bay NMS would cause local fishers to pay a cost for conservation, in terms of reductions in landed

  20. VMTL: a language for end-user model transformation

    DEFF Research Database (Denmark)

    Acretoaie, Vlad; Störrle, Harald; Strüber, Daniel

    2016-01-01

    Model transformation is a key enabling technology of Model-Driven Engineering (MDE). Existing model transformation languages are shaped by and for MDE practitioners—a user group with needs and capabilities which are not necessarily characteristic of modelers in general. Consequently, these langua......Model transformation is a key enabling technology of Model-Driven Engineering (MDE). Existing model transformation languages are shaped by and for MDE practitioners—a user group with needs and capabilities which are not necessarily characteristic of modelers in general. Consequently......, these languages are largely ill-equipped for adoption by end-user modelers in areas such as requirements engineering, business process management, or enterprise architecture. We aim to introduce a model transformation language addressing the skills and requirements of end-user modelers. With this contribution, we...... hope to broaden the application scope of model transformation and MDE technology in general. We discuss the profile of end-user modelers and propose a set of design guidelines for model transformation languages addressing them. We then introduce Visual Model Transformation Language (VMTL) following...

  1. End-to-End Traffic Flow Modeling of the Integrated SCaN Network

    Science.gov (United States)

    Cheung, K.-M.; Abraham, D. S.

    2012-05-01

    In this article, we describe the analysis and simulation effort of the end-to-end traffic flow for the Integrated Space Communications and Navigation (SCaN) Network. Using the network traffic derived for the 30-day period of July 2018 from the Space Communications Mission Model (SCMM), we generate the wide-area network (WAN) bandwidths of the ground links for different architecture options of the Integrated SCaN Network. We also develop a new analytical scheme to model the traffic flow and buffering mechanism of a store-and-forward network. It is found that the WAN bandwidth of the Integrated SCaN Network is an important differentiator of different architecture options, as the recurring circuit costs of certain architecture options can be prohibitively high.

  2. Implantable cardioverter defibrillator knowledge and end-of-life device deactivation: A cross-sectional survey.

    Science.gov (United States)

    McEvedy, Samantha M; Cameron, Jan; Lugg, Eugene; Miller, Jennifer; Haedtke, Chris; Hammash, Muna; Biddle, Martha J; Lee, Kyoung Suk; Mariani, Justin A; Ski, Chantal F; Thompson, David R; Chung, Misook Lee; Moser, Debra K

    2018-01-01

    End-of-life implantable cardioverter defibrillator deactivation discussions should commence before device implantation and be ongoing, yet many implantable cardioverter defibrillators remain active in patients' last days. To examine associations among implantable cardioverter defibrillator knowledge, patient characteristics and attitudes to implantable cardioverter defibrillator deactivation. Cross-sectional survey using the Experiences, Attitudes and Knowledge of End-of-Life Issues in Implantable Cardioverter Defibrillator Patients Questionnaire. Participants were classified as insufficient or sufficient implantable cardioverter defibrillator knowledge and the two groups were compared. Implantable cardioverter defibrillator recipients ( n = 270, mean age 61 ± 14 years; 73% male) were recruited from cardiology and implantable cardioverter defibrillator clinics attached to two tertiary hospitals in Melbourne, Australia, and two in Kentucky, the United States. Participants with insufficient implantable cardioverter defibrillator knowledge ( n = 77, 29%) were significantly older (mean age 66 vs 60 years, p = 0.001), less likely to be Caucasian (77% vs 87%, p  = 0.047), less likely to have received implantable cardioverter defibrillator shocks (26% vs 40%, p = 0.031), and more likely to have indications of mild cognitive impairment (Montreal Cognitive Assessment score defibrillator knowledge was associated with attitudes suggesting unwillingness to discuss implantable cardioverter defibrillator deactivation, even during the last days towards end of life ( p defibrillator recipients, especially those who are older or have mild cognitive impairment, often have limited knowledge about implantable cardioverter defibrillator deactivation. This study identified several potential teachable moments throughout the patients' treatment trajectory. An interdisciplinary approach is required to ensure that discussions about implantable cardioverter

  3. Sectioning Clay Models Makes Anatomy & Development Tangible

    Science.gov (United States)

    Howell, Carina Endres; Howell, James Endres

    2010-01-01

    Clay models have proved to be useful teaching aids for many topics in biology that depend on three-dimensional reasoning. Students studying embryonic development struggle to mentally reconstruct the three-dimensional structure of embryos and larvae by observing prepared slides of cross-sectional slices. Students who build clay models of embryos…

  4. End Users and ERP Systems� Success. Three Models

    Directory of Open Access Journals (Sweden)

    Gianina MIHAI

    2017-06-01

    Full Text Available Information systems (IS have an enormous impact on organizations, individual work, and performance in general. As a result, many research works in the field of IS are focused on the interrelationship between individual performance and IS performance. During the last 20 to 30 years many models have been developed and tested by researchers. Their main objective was to investigate IS success and user performance in different environments. Therefore, a number of models appeared, their goal being the studying of the success, usefulness, end user adoption and utilization of IS, and other user and IS-related aspects in different organizations. This research paper presents three of the most important models developed in specialized literature, which deal with measuring IS success and end user adoption of the IS: the TAM model, the D&M model, and the TTF model. The research also provides an overview of some studies that have applied these models in the field of ERP systems.

  5. Prediction, scenarios and insight: The uses of an end-to-end model

    Science.gov (United States)

    Steele, John H.

    2012-09-01

    A major function of ecosystem models is to provide extrapolations from observed data in terms of predictions or scenarios or insight. These models can be at various levels of taxonomic resolution such as total community production, abundance of functional groups, or species composition, depending on the data input as drivers. A 40-year dynamic simulation of end-to-end processes in the Georges Bank food web is used to illustrate the input/output relations and the insights gained at the three levels of food web aggregation. The focus is on the intermediate level and the longer term changes in three functional fish guilds - planktivores, benthivores and piscivores - in terms of three ecosystem-based metrics - nutrient input, relative productivity of plankton and benthos, and food intake by juvenile fish. These simulations can describe the long term constraints imposed on guild structure and productivity by energy fluxes over the 40 years but cannot explain concurrent switches in abundance of individual species within guilds. Comparing time series data for individual species with model output provides insights; but including the data in the model would confer only limited extra information. The advantages and limitations of the three levels of resolution of models in relation to ecosystem-based management are: The correlations between primary production and total yield of fish imply a “bottom-up” constraint on end-to-end energy flow through the food web that can provide predictions of such yields. Functionally defined metrics such as nutrient input, relative productivity of plankton and benthos and food intake by juvenile fish, represent bottom-up, mid-level and top-down forcing of the food web. Model scenarios using these metrics can demonstrate constraints on the productivity of these functionally defined guilds within the limits set by (1). Comparisons of guild simulations with time series of fish species provide insight into the switches in species dominance

  6. Impacts of the Deepwater Horizon oil spill evaluated using an end-to-end ecosystem model.

    Science.gov (United States)

    Ainsworth, Cameron H; Paris, Claire B; Perlin, Natalie; Dornberger, Lindsey N; Patterson, William F; Chancellor, Emily; Murawski, Steve; Hollander, David; Daly, Kendra; Romero, Isabel C; Coleman, Felicia; Perryman, Holly

    2018-01-01

    We use a spatially explicit biogeochemical end-to-end ecosystem model, Atlantis, to simulate impacts from the Deepwater Horizon oil spill and subsequent recovery of fish guilds. Dose-response relationships with expected oil concentrations were utilized to estimate the impact on fish growth and mortality rates. We also examine the effects of fisheries closures and impacts on recruitment. We validate predictions of the model by comparing population trends and age structure before and after the oil spill with fisheries independent data. The model suggests that recruitment effects and fishery closures had little influence on biomass dynamics. However, at the assumed level of oil concentrations and toxicity, impacts on fish mortality and growth rates were large and commensurate with observations. Sensitivity analysis suggests the biomass of large reef fish decreased by 25% to 50% in areas most affected by the spill, and biomass of large demersal fish decreased even more, by 40% to 70%. Impacts on reef and demersal forage caused starvation mortality in predators and increased reliance on pelagic forage. Impacts on the food web translated effects of the spill far away from the oiled area. Effects on age structure suggest possible delayed impacts on fishery yields. Recovery of high-turnover populations generally is predicted to occur within 10 years, but some slower-growing populations may take 30+ years to fully recover.

  7. Impacts of the Deepwater Horizon oil spill evaluated using an end-to-end ecosystem model

    Science.gov (United States)

    Paris, Claire B.; Perlin, Natalie; Dornberger, Lindsey N.; Patterson, William F.; Chancellor, Emily; Murawski, Steve; Hollander, David; Daly, Kendra; Romero, Isabel C.; Coleman, Felicia; Perryman, Holly

    2018-01-01

    We use a spatially explicit biogeochemical end-to-end ecosystem model, Atlantis, to simulate impacts from the Deepwater Horizon oil spill and subsequent recovery of fish guilds. Dose-response relationships with expected oil concentrations were utilized to estimate the impact on fish growth and mortality rates. We also examine the effects of fisheries closures and impacts on recruitment. We validate predictions of the model by comparing population trends and age structure before and after the oil spill with fisheries independent data. The model suggests that recruitment effects and fishery closures had little influence on biomass dynamics. However, at the assumed level of oil concentrations and toxicity, impacts on fish mortality and growth rates were large and commensurate with observations. Sensitivity analysis suggests the biomass of large reef fish decreased by 25% to 50% in areas most affected by the spill, and biomass of large demersal fish decreased even more, by 40% to 70%. Impacts on reef and demersal forage caused starvation mortality in predators and increased reliance on pelagic forage. Impacts on the food web translated effects of the spill far away from the oiled area. Effects on age structure suggest possible delayed impacts on fishery yields. Recovery of high-turnover populations generally is predicted to occur within 10 years, but some slower-growing populations may take 30+ years to fully recover. PMID:29370187

  8. A Computational Analysis Model for Open-ended Cognitions

    Science.gov (United States)

    Morita, Junya; Miwa, Kazuhisa

    In this paper, we propose a novel usage for computational cognitive models. In cognitive science, computational models have played a critical role of theories for human cognitions. Many computational models have simulated results of controlled psychological experiments successfully. However, there have been only a few attempts to apply the models to complex realistic phenomena. We call such a situation ``open-ended situation''. In this study, MAC/FAC (``many are called, but few are chosen''), proposed by [Forbus 95], that models two stages of analogical reasoning was applied to our open-ended psychological experiment. In our experiment, subjects were presented a cue story, and retrieved cases that had been learned in their everyday life. Following this, they rated inferential soundness (goodness as analogy) of each retrieved case. For each retrieved case, we computed two kinds of similarity scores (content vectors/structural evaluation scores) using the algorithms of the MAC/FAC. As a result, the computed content vectors explained the overall retrieval of cases well, whereas the structural evaluation scores had a strong relation to the rated scores. These results support the MAC/FAC's theoretical assumption - different similarities are involved on the two stages of analogical reasoning. Our study is an attempt to use a computational model as an analysis device for open-ended human cognitions.

  9. Optical Model and Cross Section Uncertainties

    Energy Technology Data Exchange (ETDEWEB)

    Herman,M.W.; Pigni, M.T.; Dietrich, F.S.; Oblozinsky, P.

    2009-10-05

    Distinct minima and maxima in the neutron total cross section uncertainties were observed in model calculations using spherical optical potential. We found this oscillating structure to be a general feature of quantum mechanical wave scattering. Specifically, we analyzed neutron interaction with 56Fe from 1 keV up to 65 MeV, and investigated physical origin of the minima.We discuss their potential importance for practical applications as well as the implications for the uncertainties in total and absorption cross sections.

  10. Design and end-to-end modelling of a deployable telescope

    Science.gov (United States)

    Dolkens, Dennis; Kuiper, Hans

    2017-09-01

    a closed-loop system based on measurements of the image sharpness as well as measurements obtained with edge sensors placed between the mirror segments. In addition, a phase diversity system will be used to recover residual wavefront aberrations. To aid the design of the deployable telescope, an end-to-end performance model was developed. The model is built around a dedicated ray-trace program written in Matlab. This program was built from the ground up for the purpose of modelling segmented telescope systems and allows for surface data computed with Finite Element Models (FEM) to be imported in the model. The program also contains modules which can simulate the closed-loop calibration of the telescope and it can use simulated images as an input for phase diversity and image processing algorithms. For a given thermo-mechanical state, the end-to-end model can predict the image quality that will be obtained after the calibration has been completed and the image has been processed. As such, the model is a powerful systems engineering tool, which can be used to optimize the in-orbit performance of a segmented, deployable telescope.

  11. Model of a generator end-winding cage

    International Nuclear Information System (INIS)

    Leger, A.C.; Fanton, J.P.; Davies, C.

    1994-09-01

    This document presents some studies concerning the vibratory characterization of particular structures called: generator end-winding cages. These structures are mainly made up of the endings of armature windings. The question of their good mechanical behaviour is of prime importance, since they are submitted to high electromagnetic efforts during the different electrical ratings encountered during operation. The designer (GEC-Alsthom) and the user (EDF) have both undertaken numerical calculations in order to characterize a given machine, in this case a 600 MW bipolar generator; it appeared interesting to compare such calculations. The models realized respectively by GEC-Alsthom and EDF make use of different techniques and hypotheses. GEC-Alsthom represents the sets of rods and spacers by plates, which properties are determined by a pre-processor. The model is simplified to take into account the existing symmetries. It takes profit of previous experience and aims at a fast utilisation. The EDF model tends to allow a further comprehensive calculation, form the electromagnetic efforts to the determination of local stresses. The whole set of the constituting elements of the structure is modelled by beams, which leads to an important size for the model (21 000 degrees of freedom). The validation performed on the two models has been focused on the comparison between respective results and also with experimental results. Each model provides values for the first eigenfrequencies and the associated modes shapes. (authors). 3 refs., 3 figs., 2 tabs

  12. Requirements engineering for cross-sectional information chain models.

    Science.gov (United States)

    Hübner, U; Cruel, E; Gök, M; Garthaus, M; Zimansky, M; Remmers, H; Rienhoff, O

    2012-01-01

    Despite the wealth of literature on requirements engineering, little is known about engineering very generic, innovative and emerging requirements, such as those for cross-sectional information chains. The IKM health project aims at building information chain reference models for the care of patients with chronic wounds, cancer-related pain and back pain. Our question therefore was how to appropriately capture information and process requirements that are both generally applicable and practically useful. To this end, we started with recommendations from clinical guidelines and put them up for discussion in Delphi surveys and expert interviews. Despite the heterogeneity we encountered in all three methods, it was possible to obtain requirements suitable for building reference models. We evaluated three modelling languages and then chose to write the models in UML (class and activity diagrams). On the basis of the current project results, the pros and cons of our approach are discussed.

  13. Investigating brain responses to section endings in tonal, classical and rhythmic music : an fMRI study

    OpenAIRE

    Brun, Mona

    2010-01-01

    Our overall aim was to examine brain responses to different experiences of time in music with a particular focus on the question of how we experience large-scale music form. The present experiment was aimed at investigating the neural correlates to experiencing section endings in teleological (goal-directed) music as well as in rhythmic (groove-based) music. We used functional magnetic resonance imaging (fMRI) on 14 human participants. Comparing transition points to continuous sections of ...

  14. Modeling volatile isoprenoid emissions--a story with split ends.

    Science.gov (United States)

    Grote, R; Niinemets, U

    2008-01-01

    Accurate prediction of plant-generated volatile isoprenoid fluxes is necessary for reliable estimation of atmospheric ozone and aerosol formation potentials. In recent years, significant progress has been made in understanding the environmental and physiological controls on isoprenoid emission and in scaling these emissions to canopy and landscape levels. We summarize recent developments and compare different approaches for simulating volatile isoprenoid emission and scaling up to whole forest canopies with complex architecture. We show that the current developments in modeling volatile isoprenoid emissions are "split-ended" with simultaneous but separated efforts in fine-tuning the empirical emission algorithms and in constructing process-based models. In modeling volatile isoprenoid emissions, simplified leaf-level emission algorithms (Guenther algorithms) are highly successful, particularly after scaling these models up to whole regions, where the influences of different ecosystem types, ontogenetic stages, and variations in environmental conditions on emission rates and dynamics partly cancel out. However, recent experimental evidence indicates important environmental effects yet unconsidered and emphasize, the importance of a highly dynamic plant acclimation in space and time. This suggests that current parameterizations are unlikely to hold in a globally changing and dynamic environment. Therefore, long-term predictions using empirical algorithms are not necessarily reliable. We show that process-based models have large potential to capture the influence of changing environmental conditions, in particular if the leaf models are linked with physiologically based whole-plant models. This combination is also promising in considering the possible feedback impacts of emissions on plant physiological status such as mitigation of thermal and oxidative stresses by volatile isoprenoids. It might be further worth while to incorporate main features of these approaches

  15. Combining interviewing and modeling for end-user energy conservation

    International Nuclear Information System (INIS)

    Goldblatt, David L.; Hartmann, Christoph; Duerrenberger, Gregor

    2005-01-01

    Studying energy consumption through the lens of households is an increasingly popular research avenue. This paper focuses on residential end-user energy conservation. It describes an approach that combines energy modeling and in-depth interviews for communicating about energy use and revealing consumer preferences for change at different levels and intervention points. Expert knowledge was embodied in a computer model for householders that calculates an individual's current energy consumption and helps assess personal savings potentials, while also bringing in socio-technical and economic elements beyond the user's direct control. The paper gives a detailed account of this computer information tool developed for interviewing purposes. It then describes the interview guidelines, data analysis, and main results. In general, interview subjects overestimated the environmental friendliness of their lifestyles. After experience with the program, they tended to rate external (technological, societal) factors as somewhat stronger determinants of their consumption levels than personal (behavioral and household investment) factors, with the notable exception of mobility. Concerning long-term energy perspectives, the majority of subjects felt that society has the ability to make a collective choice towards significantly lower energy consumption levels. Interviewees confirmed that the software and interactive sessions helped them think more holistically about the personal, social, and technological dimensions of energy conservation. Lessons can be applied to the development of future energy communication tools

  16. Annual report of the Neutron Physics Section : period ending December 1976

    International Nuclear Information System (INIS)

    Joneja, O.P.; Ramanandham, M.

    1977-01-01

    Research activities of the Neutron Physics Section of the Bhabha Atomic Research Centre, Bombay, for the period July 1975 - December 1976 are reported. Work in the field of : (1) X-ray and neutron crystallography of molecules of biological interest, (2) phase transformations of various kinds and (3) reactor physics and applied neutron physics is being continued. Some of the highlights are : (1) TDC-312 computer controlled neutron diffractometer has been put into operation, (2) two critical configurations using U 233 -uranyl nitrate solution have been planned, (3) vapourisation, melting and other phenomena in rocks as a result of an underground nuclear explosion have been studied. In this connection, computer codes for the propagation of shock waves in rocks using numerical simulation techniques have been developed. (M.G.B.)

  17. Hydraulic impact end effector final test report. Automation and robotics section, ER/WM-AT Program

    Energy Technology Data Exchange (ETDEWEB)

    Couture, S.

    1994-02-18

    One tool being developed for dislodging and fragmenting the hard salt cake waste in the single-shell nuclear waste tanks at the Hanford Reservation near Richland, Washington, is the hydraulic impact end effector (HIEE). This total operates by discharging 11-in. slugs of water at ultrahigh pressures. The HIEE was designed, built, and initially tested in 1992. Work in 1993 included advanced developments of the HIEE to further investigate its fragmentation abilities and to determine more effective operating procedures. These tests showed that more fragmentation can be achieved by increasing the charge pressure of 40 kpsi to 55 kpsi and by the use of different operating procedures. The size of the material and the impact energy of the water slug fired from the HIEE are believed to be major factors in material fragmentation. The material`s ability to fracture also appears to depend on the distance a fracture or crack line must travel to a free surface. Thus, larger material is more difficult to fracture than smaller material. Discharge pressures of 40 kpsi resulted in little penetration or fracturing of the material. At 55 kpsi, however, the size and depth of the fractures increased. Nozzle geometry had a significant effect on fragment size and quantity. Fragmentation was about an order of magnitude greater when the HIEE was discharged into drilled holes rather than onto the material surface. Since surface shots tend to create craters, a multi-shot procedure, coupled with an advanced nozzle design, was used to drill (crater) deep holes into large material. With this procedure, a 600-lb block was reduced to smaller pieces without the use of any additional equipment. Through this advanced development program, the HIEE has demonstrated that it can quickly fragment salt cake material into small, easily removable fragments. The HIEE`s material fragmentation ability can be substantially increased through the use of different nozzle geometries and operating procedures.

  18. Hydraulic impact end effector final test report. Automation and robotics section, ER/WM-AT Program

    International Nuclear Information System (INIS)

    Couture, S.

    1994-01-01

    One tool being developed for dislodging and fragmenting the hard salt cake waste in the single-shell nuclear waste tanks at the Hanford Reservation near Richland, Washington, is the hydraulic impact end effector (HIEE). This total operates by discharging 11-in. slugs of water at ultrahigh pressures. The HIEE was designed, built, and initially tested in 1992. Work in 1993 included advanced developments of the HIEE to further investigate its fragmentation abilities and to determine more effective operating procedures. These tests showed that more fragmentation can be achieved by increasing the charge pressure of 40 kpsi to 55 kpsi and by the use of different operating procedures. The size of the material and the impact energy of the water slug fired from the HIEE are believed to be major factors in material fragmentation. The material's ability to fracture also appears to depend on the distance a fracture or crack line must travel to a free surface. Thus, larger material is more difficult to fracture than smaller material. Discharge pressures of 40 kpsi resulted in little penetration or fracturing of the material. At 55 kpsi, however, the size and depth of the fractures increased. Nozzle geometry had a significant effect on fragment size and quantity. Fragmentation was about an order of magnitude greater when the HIEE was discharged into drilled holes rather than onto the material surface. Since surface shots tend to create craters, a multi-shot procedure, coupled with an advanced nozzle design, was used to drill (crater) deep holes into large material. With this procedure, a 600-lb block was reduced to smaller pieces without the use of any additional equipment. Through this advanced development program, the HIEE has demonstrated that it can quickly fragment salt cake material into small, easily removable fragments. The HIEE's material fragmentation ability can be substantially increased through the use of different nozzle geometries and operating procedures

  19. ROXIE the Routine for the Optimization of Magnet X-sections, Inverse Field Computation and Coil End Design

    CERN Document Server

    Russenschuck, Stephan

    1999-01-01

    The ROXIE software program package has been developed for the design of the superconducting magnets for the LHC at CERN. The software is used as an approach towards the integrated design of superconducting magnets including feature-based coil geometry creation, conceptual design using genetic algorithms, optimization of the coil and iron cross-sections using a reduced vector-potential formulation, 3-D coil end geometry and field optimization using deterministic vector- optimization techniques, tolerance analysis, production of drawings by means of a DXF interface, end-spacer design with interfaces to CAD-CAM for the CNC machining of these pieces, and the tracing of manufacturing errors using field quality measurements. This paper gives an overview of the methods applied in the ROXIE program. (9 refs).

  20. Modeling, simulation, and optimization of a front-end system for acetylene hydrogenation reactors

    Directory of Open Access Journals (Sweden)

    R. Gobbo

    2004-12-01

    Full Text Available The modeling, simulation, and dynamic optimization of an industrial reaction system for acetylene hydrogenation are discussed in the present work. The process consists of three adiabatic fixed-bed reactors, in series, with interstage cooling. These reactors are located after the compression and the caustic scrubbing sections of an ethylene plant, characterizing a front-end system; in contrast to the tail-end system where the reactors are placed after the de-ethanizer unit. The acetylene conversion and selectivity profiles for the reactors are optimized, taking into account catalyst deactivation and process constraints. A dynamic optimal temperature profile that maximizes ethylene production and meets product specifications is obtained by controlling the feed and intercoolers temperatures. An industrial acetylene hydrogenation system is used to provide the necessary data to adjust kinetics and transport parameters and to validate the approach.

  1. AM2 Mat End Connector Modeling and Performance Validation

    Science.gov (United States)

    2015-08-01

    Figure 32. Crack at weld and broken lower overlap rail at I-42. ............................................................ 31 Figure 33. Skin tear and...minor cracking on surface - - I-24 Crack along weld that began at south edge, 2.5 in. long - - I-25 Upper underlap rail broke 4 9.5 807 I-25...of underlap end connector - - I-42 Lower overlap rail broke length of 9 in., starting at female hinge edge. Crack at end connector weld from

  2. End-to-end models for marine ecosystems: Are we on the precipice of a significant advance or just putting lipstick on a pig?

    Directory of Open Access Journals (Sweden)

    Kenneth A. Rose

    2012-02-01

    Full Text Available There has been a rapid rise in the development of end-to-end models for marine ecosystems over the past decade. Some reasons for this rise include need for predicting effects of climate change on biota and dissatisfaction with existing models. While the benefits of a well-implemented end-to-end model are straightforward, there are many challenges. In the short term, my view is that the major role of end-to-end models is to push the modelling community forward, and to identify critical data so that these data can be collected now and thus be available for the next generation of end-to-end models. I think we should emulate physicists and build theoretically-oriented models first, and then collect the data. In the long-term, end-to-end models will increase their skill, data collection will catch up, and end-to-end models will move towards site-specific applications with forecasting and management capabilities. One pathway into the future is individual efforts, over-promise, and repackaging of poorly performing component submodels (“lipstick on a pig”. The other pathway is a community-based collaborative effort, with appropriate caution and thoughtfulness, so that the needed improvements are achieved (“significant advance”. The promise of end-to-end modelling is great. We should act now to avoid missing a great opportunity.

  3. Far-Infrared Therapy Promotes Nerve Repair following End-to-End Neurorrhaphy in Rat Models of Sciatic Nerve Injury

    Directory of Open Access Journals (Sweden)

    Tai-Yuan Chen

    2015-01-01

    Full Text Available This study employed a rat model of sciatic nerve injury to investigate the effects of postoperative low-power far-infrared (FIR radiation therapy on nerve repair following end-to-end neurorrhaphy. The rat models were divided into the following 3 groups: (1 nerve injury without FIR biostimulation (NI/sham group; (2 nerve injury with FIR biostimulation (NI/FIR group; and (3 noninjured controls (normal group. Walking-track analysis results showed that the NI/FIR group exhibited significantly higher sciatic functional indices at 8 weeks after surgery (P<0.05 compared with the NI/sham group. The decreased expression of CD4 and CD8 in the NI/FIR group indicated that FIR irradiation modulated the inflammatory process during recovery. Compared with the NI/sham group, the NI/FIR group exhibited a significant reduction in muscle atrophy (P<0.05. Furthermore, histomorphometric assessment indicated that the nerves regenerated more rapidly in the NI/FIR group than in the NI/sham group; furthermore, the NI/FIR group regenerated neural tissue over a larger area, as well as nerve fibers of greater diameter and with thicker myelin sheaths. Functional recovery, inflammatory response, muscular reinnervation, and histomorphometric assessment all indicated that FIR radiation therapy can accelerate nerve repair following end-to-end neurorrhaphy of the sciatic nerve.

  4. Business modelling in the fuzzy front end of innovation

    NARCIS (Netherlands)

    Limonard, A.J.P.; Berkers, F.T.H.M.; Niamut, O.A.; Bachet, T.T.; Reuver, M. de

    2011-01-01

    In this paper we address the techno-economic dilemma in the fuzzy front end of R&D consortia: how to bridge the gap between the lack of knowledge on future demand for a technology and the need to make design decisions. The problem in these types of collaborations that the business interests to

  5. Modeling material failure during cab car end frame impact

    Science.gov (United States)

    2009-03-03

    New standards have been proposed to increase the strength requirements for cab car end structures and impose further requirements on their ability to absorb energy during a grade-crossing collision. This conference paper reports on a set of full-scal...

  6. Modelling axisymmetric cod-ends made of different mesh types

    DEFF Research Database (Denmark)

    Priour, D.; Herrmann, Bent; O'Neill, F.G.

    2009-01-01

    Cod-ends are the rearmost part of trawl fishing gears. They collect the catch, and for many important species it is where fish selection takes place. Generally speaking they are axisymmetric, and their shape is influenced by the catch volume, the mesh shape, and the material characteristics. The ...

  7. Progress report of the Radiation Technology and Industrial Applications Section, Isotope Group for the period ending August 1977

    International Nuclear Information System (INIS)

    Naik, A.D.; Roy, A.N.; Majali, A.B.

    1977-01-01

    The activities of the Radiation Technology and Industrial Applications Section of the Bhabha Atomic Research Centre, Bombay, for the period ending August 1977 are reported. Major highlights are: (1) completion of studies and design engineering for an economic scale cobalt-60 based irradiator for the radiation sterilisation of medical products, (2) taking up the work of setting up the cobalt-60 irradiation facilities for sources up to 300,000 Ci level, (3) development of radiation processed wood-polymer composite and practical demonstration of its superiority for application in industries - a cobalt-60 facility specifically for this purpose is being installed, (4) development of a commercially viable design of a smoke alarm system based on radioisotopes and (5) production and supply of irradiation units such as gamma chambers, radiography cameras, etc. (M.G.B.)

  8. Oncology nurses' perceptions of obstacles and role at the end-of-life care: cross sectional survey.

    Science.gov (United States)

    Blaževičienė, Aurelija; Newland, Jamesetta A; Čivinskienė, Vilija; Beckstrand, Renea L

    2017-12-19

    Major obstacles exist in the care of patients at the end of life: lack of time, poor or inadequate communication, and lack of knowledge in providing care. Three possible nursing roles in care decision-making were investigated: Information Broker, Supporter, and Advocate. The purpose of this study was to examine obstacles faced by oncology nurses in providing end-of-life (EOL) care and to examine roles of nurses in providing care. A descriptive, cross-sectional, correlational design was applied. The study was conducted at two major University Hospitals of Oncology in Lithuania that have a combined total of 2365 beds. The study sample consisted of 239 oncology registered nurses. Data collection tool included a questionnaire about assessment of obstacles and supportive behaviors, nursing roles, and socio-demographic characteristics. The two items perceived by respondents as the most intense obstacles to providing EOL care were The nurse's opinion on immediate patient care is not welcome, valued or discussed and. Family has no access to psychological help after being informed about the patient's diagnosis. The majority of respondents self-assigned the role of Supporter. Major obstacles in providing care included the nurse's opinion that immediate patient care was not valued, lack of nursing knowledge on how to treat the patient's grieving family, and physicians who avoided conversations with the patient and family members about diagnoses and prospects. In EOL care nurses most frequently acted as Supporters and less frequently as Advocates.

  9. Effect of Supplementing Oxygen with Positive end Expiratory Pressure During Elective Caesarean Section under Spinal Anaesthesia on Foetus

    Science.gov (United States)

    Prabhu, Ramesh; Jayaraj; Shenoy, U Kailasanath

    2010-01-01

    Background: It is known fact that pre-oxygenation with positive end-expiratory pressure (PEEP) improves the Partial pressure of oxygen (PO 2). In this regard not many studies have been done in pregnant women to know its effect on foetus. In this randomised double blind controlled study, we analysed effect of pre-oxygenation with PEEP during caesarean section on foetal umbilical venous PO 2. Patients & Methods: 40 term pregnant women, ASA I or II, undergoing elective Caesarean section under spinal anaes-thesia were randomly divided into PEEP and Non-PEEP groups of 20 each. PEEP group received oxygen flow of 6 L/minute with PEEP of 5 cmH 2O using a modified Mapleson A circuit with fixed unidirectional PEEP valve at the expiratory port during pre-oxygenation and Non PEEP group received same fresh gas flow of oxygen using same breathing circuit without PEEP. Maternal arterial blood samples were collected before applying PEEP and at the end of 5 minutes of facemask application for oxygen analysis. Immediately after baby was delivered umbilical venous samples were taken for blood gas analysis. Results: Both groups were comparable in terms of maternal baseline oxygen saturation (Spo 2) and base line Po 2. After 5 minutes PO 2was higher in PEEP Group than non PEEP group (491.65 + 49.96 vs. 452.08 + 77.61). Umbilical venous Po 2in PEEP group was higher than non PEEP group (34.22 + 6.50 vs. 28.29 + 6.10 mm of Hg). Conclusion: Application of PEEP during pre-oxygenation for spinal anaesthesia can increase foetal umbilical venous PO2. PMID:21547172

  10. Models for photon-photon total cross-sections

    International Nuclear Information System (INIS)

    Godbole, R.M.; Grau, A.; Pancheri, G.

    1999-01-01

    The paper presents here a brief overview of recent models describing the photon-photon cross-section into hadrons. It shall be showed in detail results from the eikonal minijet model, with and without soft gluon summation

  11. Learning of Cross-Sectional Anatomy Using Clay Models

    Science.gov (United States)

    Oh, Chang-Seok; Kim, Ji-Young; Choe, Yeon Hyeon

    2009-01-01

    We incorporated clay modeling into gross anatomy and neuro-anatomy courses to help students understand cross-sectional anatomy. By making clay models, cutting them and comparing cut surfaces to CT and MR images, students learned how cross-sectional two-dimensional images were created from three-dimensional structure of human organs. Most students…

  12. West Coast fish, mammal, bird life history and abunance parameters - Developing end-to-end models of the California Current Large Marine Ecosystem

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project is to develop spatially discrete end-to-end models of the California Current LME, linking oceanography, biogeochemistry, food web...

  13. West Coast fish, mammal, and bird species diets - Developing end-to-end models of the California Current Large Marine Ecosystem

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project is to develop spatially discrete end-to-end models of the California Current LME, linking oceanography, biogeochemistry, food web...

  14. Gulf of California species and catch spatial distributions and historical time series - Developing end-to-end models of the Gulf of California

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project is to develop spatially discrete end-to-end models of the northern Gulf of California, linking oceanography, biogeochemistry, food web...

  15. End-of-life care in general practice: A cross-sectional, retrospective survey of 'cancer', 'organ failure' and 'old-age/dementia' patients

    NARCIS (Netherlands)

    Evans, N.C.; Pasman, H.R.W.; Donker, G.A.; Deliens, L.; Block, L.; Onwuteaka-Philipsen, B.D.

    2014-01-01

    Background: End-of-life care is often provided in primary care settings. Aim: To describe and compare general-practitioner end-of-life care for Dutch patients who died from 'cancer', 'organ failure' and 'old-age or dementia'. Design: A cross-sectional, retrospective survey was conducted within a

  16. Lizards from the end of the world: phylogenetic relationships of the Liolaemus lineomaculatus section (Squamata: Iguania: Liolaemini).

    Science.gov (United States)

    Breitman, M Florencia; Avila, Luciano J; Sites, Jack W; Morando, Mariana

    2011-05-01

    The Liolaemus lineomaculatus section is a geographically widely distributed group of lizards from the Patagonian region of southern South America, and includes 18 described species representing the most southerly distributed Liolaemus taxa (the genus includes 228 species and extends from Tierra del Fuego north to south-central Peru). Despite high species diversity, the phylogenetic relationships of this section are unknown. In the present work we sampled all described species in the L. lineomaculatus section as well as currently undescribed candidate species to reconstruct the first complete phylogenetic hypothesis for the clade. Our data set included four anonymous nuclear loci, three nuclear protein-coding loci, and two mitochondrial genes. We compared results obtained with three different phylogenetic methods for the concatenated data set (Maximum Parsimony, Maximum Likelihood and Bayesian Inference) with a coalescent-based species tree approach (BEST), and recovered congruent, strongly-supported topological arrangements across all methods. We identified four main clades within the L. lineomaculatus section: the lineomaculatus, magellanicus, somuncurae, and kingii+archeforus groups, for which we estimated divergence times. We discuss the taxonomic implications of these results and how the future integration of phylogeographic, niche modeling and morphological approaches will allow testing biogeographical hypotheses in this clade. Copyright © 2011 Elsevier Inc. All rights reserved.

  17. Models for Pooled Time-Series Cross-Section Data

    Directory of Open Access Journals (Sweden)

    Lawrence E Raffalovich

    2015-07-01

    Full Text Available Several models are available for the analysis of pooled time-series cross-section (TSCS data, defined as “repeated observations on fixed units” (Beck and Katz 1995. In this paper, we run the following models: (1 a completely pooled model, (2 fixed effects models, and (3 multi-level/hierarchical linear models. To illustrate these models, we use a Generalized Least Squares (GLS estimator with cross-section weights and panel-corrected standard errors (with EViews 8 on the cross-national homicide trends data of forty countries from 1950 to 2005, which we source from published research (Messner et al. 2011. We describe and discuss the similarities and differences between the models, and what information each can contribute to help answer substantive research questions. We conclude with a discussion of how the models we present may help to mitigate validity threats inherent in pooled time-series cross-section data analysis.

  18. Mathematical models of the pregnant woman at the end of the first trimester

    International Nuclear Information System (INIS)

    Watson, E.E.; Stabin, M.G.; Eckerman, K.F.; Cristy, M.; Ryman, J.C.; Davis, J.F.

    1989-01-01

    Most calculations of absorbed doses from radionuclides in the body are based on a mathematical model of Reference Man with no consideration of persons of different sizes nor of the different geometric relationships of organs as in women and children. This is inappropriate for the pregnant woman, particularly as the pregnancy progresses. Many of the mother's abdominal organs are repositioned and their shapes changed. Existing mathematical models need to be modified to reflect these changes and improve the accuracy of absorbed dose estimates. Models of the pregnant woman at the end of the first and third trimester have been developed. These models are modifications of the adult female model that is part of the Oak Ridge National Laboratory phantom series. The models for both the three- and nine-month models were patterned after anatomic information appearing in obstetric texts and reports. The three-month model incorporated changes in the size and shape of the uterus as well as in the urinary bladder, the small intestine, and portions of the large intestine. The changes in the Reference Woman model to approximate the nine-month model are much more extensive. Many organs including the uterus plus contents, stomach, small intestine, upper and lower large intestine, pelvis, urinary bladder, and liver were remodeled. The outside of the trunk also had to be enlarged to accommodate the uterus. Volumes for the mother's organs were maintained at the values proposed for the Reference Woman phantom. The uterine contents at nine-months were divided into fetal soft tissues, fetal skeleton, and other tissues within the uterus so that estimates of specific absorbed fractions can be calculated for various sections of the fetus as well as for the total fetus

  19. Predictors of dietary and fluid non-adherence in Jordanian patients with end-stage renal disease receiving haemodialysis: a cross-sectional study.

    Science.gov (United States)

    Khalil, Amani A; Darawad, Muhammad; Al Gamal, Eklas; Hamdan-Mansour, Ayman M; Abed, Mona A

    2013-01-01

    The purpose of this study is to provide insight into the relationship between dietary and fluid non-adherence, depressive symptoms, quality of life, perceived barriers and benefits of exercise, and perceived social support among Jordanian patients with end-stage renal disease receiving haemodialysis using Pender's health promotion model. Non-adherence to dietary and fluid restrictions is a leading cause of treatment failure and poor outcomes in end-stage renal disease. Yet, factors that interfere with the patients' ability to follow their dietary restrictions are unknown. A descriptive, correlational, cross-sectional design was used. Jordanian patients (n = 190) with end-stage renal disease receiving haemodialysis from three main Jordanian cities were included. The dialysis diet and fluid nonadherence questionnaire, Beck Depression Inventory-II, Quality Of Life Index, Dialysis Patient-Perceived Exercise Benefits and Barriers Scale, and the Multidimensional Perceived Social Support were employed to measure the key variables. Patients were more likely men with mean age of 48·2 ± 14·9. Only 27% of the patients showed full commitment to diet guidelines and 23% to fluid guidelines during the last 14 days. Depression (M = 18·8 ± 11·4) had significant negative association with quality of life (importance and satisfaction) (r = -0·60, r = -0·32, p = 0·001, respectively). Multiple hierarchal regressions revealed a predictive model of only two variables: age (B = -0·22, p = 0·05) and residual renal function (B = -0·23, p = 0·012) for dietary non-adherence. Non-adherence to diet and fluid guidelines association with individual characteristics, health perception and psychosocial variables should be investigated in a longitudinal design. Relationship of non-adherence with culture-related factors should deeply be assessed among Jordanian patients with end-stage renal disease receiving haemodialysis. Identification of the factors that may worsen dietary and fluid non

  20. A PROFICIENT MODEL FOR HIGH END SECURITY IN CLOUD COMPUTING

    Directory of Open Access Journals (Sweden)

    R. Bala Chandar

    2014-01-01

    Full Text Available Cloud computing is an inspiring technology due to its abilities like ensuring scalable services, reducing the anxiety of local hardware and software management associated with computing while increasing flexibility and scalability. A key trait of the cloud services is remotely processing of data. Even though this technology had offered a lot of services, there are a few concerns such as misbehavior of server side stored data , out of control of data owner's data and cloud computing does not control the access of outsourced data desired by the data owner. To handle these issues, we propose a new model to ensure the data correctness for assurance of stored data, distributed accountability for authentication and efficient access control of outsourced data for authorization. This model strengthens the correctness of data and helps to achieve the cloud data integrity, supports data owner to have control on their own data through tracking and improves the access control of outsourced data.

  1. A Variable Flow Modelling Approach To Military End Strength Planning

    Science.gov (United States)

    2016-12-01

    behaviours of a system and how the behaviours are influenced by...Markov Chain Models Wang describes Markov chain theory as a mathematical tool used to investigate dynamic behaviours of a system in a discrete-time... Organisation . 52 THIS PAGE INTENTIONALLY LEFT BLANK 53 INITIAL DISTRIBUTION LIST 1. Defense Technical Information Center Ft Belvoir Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California

  2. Utility of Modeling End-Stage Liver Disease in Children with Chronic Liver Disease

    Directory of Open Access Journals (Sweden)

    Hamid Reza Kianifar

    2014-01-01

    Full Text Available Introduction: Chronic liver diseases consist of wide spectrum disorders that may be complicated by cirrhosis and therefore need to transplantation. The pediatric end-stage liver disease (PELD score and model of end-stage liver disease (MELD score has been used as predictors of mortality chronic liver diseases listed for liver transplantation. The aim of this study is evaluation of relation between PELDMELD score and evidence of cirrhosis in children with choronic liver disease.   Materials and Method: This cross-sectional study conducted on 106 patients of chronic liver disease referred to Ghaem Haspital, Mashhad University of Medical Science, Iran during 24 months period (2010-2013. PELD and MELD score were calculated for all patients. Clincal and patholoogical findings of cirrhosis were recorded.   Results: Mean age of patients was 68/3 ± 41.8 months. Mean PELDMELD score was -1/59± 9/64. There was significant correlation between PELDMELD score and clinical icter, spelenomegaly, evidence of hepatopulminary syndrome, esophageal varices, evidence of cirrhosis in tissue specimences.   Conclusion: PELDMELD score appear to be benefit for detection of cirrhotic children among paients with choronic liver disease.

  3. Content Model Use and Development to Redeem Thin Section Records

    Science.gov (United States)

    Hills, D. J.

    2014-12-01

    The National Geothermal Data System (NGDS) is a catalog of documents and datasets that provide information about geothermal resources located primarily within the United States. The goal of NGDS is to make large quantities of geothermal-relevant geoscience data available to the public by creating a national, sustainable, distributed, and interoperable network of data providers. The Geological Survey of Alabama (GSA) has been a data provider in the initial phase of NGDS. One method by which NGDS facilitates interoperability is through the use of content models. Content models provide a schema (structure) for submitted data. Schemas dictate where and how data should be entered. Content models use templates that simplify data formatting to expedite use by data providers. These methodologies implemented by NGDS can extend beyond geothermal data to all geoscience data. The GSA, using the NGDS physical samples content model, has tested and refined a content model for thin sections and thin section photos. Countless thin sections have been taken from oil and gas well cores housed at the GSA, and many of those thin sections have related photomicrographs. Record keeping for these thin sections has been scattered at best, and it is critical to capture their metadata while the content creators are still available. A next step will be to register the GSA's thin sections with SESAR (System for Earth Sample Registration) and assign an IGSN (International Geo Sample Number) to each thin section. Additionally, the thin section records will be linked to the GSA's online record database. When complete, the GSA's thin sections will be more readily discoverable and have greater interoperability. Moving forward, the GSA is implementing use of NGDS-like content models and registration with SESAR and IGSN to improve collection maintenance and management of additional physical samples.

  4. Analytical model for shear strength of end slabs of prestressed concrete nuclear reactor vessels

    International Nuclear Information System (INIS)

    Abdulrahman, H.O.; Sozen, M.A.; Schnobrich, W.C.

    1979-04-01

    The results are presented of an investigation of the behavior and strength of flat end slabs of cylindrical prestressed concrete nuclear reactor vessels. The investigation included tests of ten small-scale pressure vessels and development of a nonlinear finite-element model to simulate the deformation response and strength of the end slabs. Because earlier experimental studies had shown that the flexural strength of the end slab could be calculated using intelligible procedures, the emphasis of this investigation was on shear strength

  5. ROXIE: Routine for the optimization of magnet X-sections, inverse field calculation and coil end design. Proceedings

    International Nuclear Information System (INIS)

    Russenschuck, S.

    1999-01-01

    The Large Hadron Collider (LHC) will provide proton-proton collisions with a center-of-mass energy of 14 TeV which requires high field superconducting magnets to guide the counter-rotating beams in the existing LEP tunnel with a circumference of about 27 km. The LHC magnet system consists of 1232 superconducting dipoles and 386 main quadrupoles together with about 20 different types of magnets for insertions and correction. The design and optimization of these magnets is dominated by the requirement of a extremely uniform field which is mainly defined by the layout of the superconducting coils. The program package ROXIE (Routine for the Optimization of magnet X-sections, Inverse field calculation and coil End design) has been developed for the design and optimization of the coil geometries in two and three dimensions. Recently it has been extended in a collaboration with the University of Graz, Austria, to the calculation of saturation induced effects using a reduced vector-potential FEM formulation. With the University of Stuttgart, Germany, a collaboration exists fro the application of the BEM-FEM coupling method for the 2D and 3D field calculation. ROXIE now also features a TCL-TK user interface. The growing number of ROXIE users inside and outside CERN gave rise to the idea of organizing the 'First International ROXIE Users Meeting and Workshop' at CERN, March 16-18, 1998 which brought together about 50 researchers in the field. This report contains the contributions to the workshop and describes the features of the program, the mathematical optimization techniques applied and gives examples of the recent design work carried out. It also gives the theoretical background for the field computation methods and serves as a handbook for the installation and application of the program. (orig.)

  6. Variation in medication use in cancer patients at the end of life: a cross-sectional analysis.

    NARCIS (Netherlands)

    Raijmakers, N.J.H.; Zuylen, L. van; Furst, C.J.; Beccaro, M.; Maiorana, L.; Pilastri, P.; Rossi, C.; Flego, G.; Heide, A. van der; Costantini, M.

    2013-01-01

    Purpose: Despite advances in cancer treatment, patients still die with unnecessary suffering. Therefore, high-quality end-of-life care is needed. Variations in medication use at the end of life may suggest areas for improvement. This study aims to describe the use of medications during the last days

  7. An integrated end-to-end modeling framework for testing ecosystem-wide effects of human-induced pressures in the Baltic Sea

    DEFF Research Database (Denmark)

    Palacz, Artur; Nielsen, J. Rasmus; Christensen, Asbjørn

    to the high-resolution coupled physical-biological model HBM-ERGOM and the fisheries bio-economic FishRent model. We investigate ecosystem-wide responses to changes in human-induced pressures by simulating several eutrophication scenarios that are relevant to existing Baltic Sea management plans (e.g. EU BSAP......, EU CFP). We further present the structure and calibration of the Baltic ATLANTIS model and the operational linkage to the other models. Using the results of eutrophication scenarios, and focusing on the relative changes in fish and fishery production, we discuss the robustness of the model linking......We present an integrated end-to-end modeling framework that enables whole-of ecosystem climate, eutrophication, and spatial management scenario exploration in the Baltic Sea. The framework is built around the Baltic implementation of the spatially-explicit end-to-end ATLANTIS model, linked...

  8. Modelling interaction cross sections for intermediate and low energy ions

    International Nuclear Information System (INIS)

    Toburen, L.H.; Shinpaugh, J.L.; Justiniano, E.L.B.

    2002-01-01

    When charged particles slow in tissue they undergo electron capture and loss processes than can have profound effects on subsequent interaction cross sections. Although a large amount of data exists for the interaction of bare charged particles with atoms and molecules, few experiments have been reported for these 'dressed' particles. Projectile electrons contribute to an impact-parameter-dependent screening of the projectile charge that precludes straightforward scaling of energy loss cross sections from those of bare charged particles. The objective of this work is to develop an analytical model for the energy-loss-dependent effects of screening on differential ionisation cross sections that can be used in track structure calculations for high LET ions. As a first step a model of differential ionisation cross sections for bare ions has been combined with a simple screening model to explore cross sections for intermediate and low energy dressed ions in collisions with atomic and molecular gas targets. The model is described briefly and preliminary results compared to measured electron energy spectra. (author)

  9. A THEORETICAL MODEL OF SUPPORTING OPEN SOURCE FRONT END INNOVATION THROUGH IDEA MANAGEMENT

    DEFF Research Database (Denmark)

    Aagaard, Annabeth

    2013-01-01

    to overcome these various challenges companies are looking for new models to support FEI. This theoretical paper explores in what way idea management may be applied as a tool in facilitation of front end innovation and how this facilitation may be captured in a conceptual model. First, I show through...... a literature study, how idea management and front end innovation are related and how they may support each other. Secondly, I present a theoretical model of how idea management may be applied in support of the open source front end of new product innovations. Thirdly, I present different venues of further...... exploration of active facilitation of open source front end innovation through idea management....

  10. An integrated end-to-end modeling framework for testing ecosystem-wide effects of human-induced pressures in the Baltic Sea

    DEFF Research Database (Denmark)

    Palacz, Artur; Nielsen, J. Rasmus; Christensen, Asbjørn

    We present an integrated end-to-end modeling framework that enables whole-of ecosystem climate, eutrophication, and spatial management scenario exploration in the Baltic Sea. The framework is built around the Baltic implementation of the spatially-explicit end-to-end ATLANTIS model, linked...... with respect to the underlying assumptions, strengths and weaknesses of individual models. Furthermore, we describe how to possibly expand the framework to account for spatial impacts and economic consequences, for instance by linking to the individual-vessel based DISPLACE modeling approach. We conclude...... that the proposed model integration and management scenario evaluation scheme lays the foundations for developing a robust framework for management strategy evaluation that is of strategic importance to stakeholders from around the Baltic Sea....

  11. Wind Tunnel Experiments with Active Control of Bridge Section Model

    DEFF Research Database (Denmark)

    Hansen, Henriette I.; Thoft-Christensen, Palle

    This paper describes results of wind tunnel experiments with a bridge section model where movable flaps are integrated in the bridge girder so each flap is the streamlined part of the edge of the girder. This active control flap system is patented by COWIconsult and may be used to increase...

  12. Network modeling for reverse flows of end-of-life vehicles

    International Nuclear Information System (INIS)

    Ene, Seval; Öztürk, Nursel

    2015-01-01

    Highlights: • We developed a network model for reverse flows of end-of-life vehicles. • The model considers all recovery operations for end-of-life vehicles. • A scenario-based model is used for uncertainty to improve real case applications. • The model is adequate to real case applications for end-of-life vehicles recovery. • Considerable insights are gained from the model by sensitivity analyses. - Abstract: Product recovery operations are of critical importance for the automotive industry in complying with environmental regulations concerning end-of-life products management. Manufacturers must take responsibility for their products over the entire life cycle. In this context, there is a need for network design methods for effectively managing recovery operations and waste. The purpose of this study is to develop a mathematical programming model for managing reverse flows in end-of-life vehicles’ recovery network. A reverse flow is the collection of used products from consumers and the transportation of these products for the purpose of recycling, reuse or disposal. The proposed model includes all operations in a product recovery and waste management network for used vehicles and reuse for vehicle parts such as collection, disassembly, refurbishing, processing (shredding), recycling, disposal and reuse of vehicle parts. The scope of the network model is to determine the numbers and locations of facilities in the network and the material flows between these facilities. The results show the performance of the model and its applicability for use in the planning of recovery operations in the automotive industry. The main objective of recovery and waste management is to maximize revenue and minimize pollution in end-of-life product operations. This study shows that with an accurate model, these activities may provide economic benefits and incentives in addition to protecting the environment

  13. Nurses' knowledge of advance directives and perceived confidence in end-of-life care: a cross-sectional study in five countries.

    LENUS (Irish Health Repository)

    Coffey, Alice

    2016-01-28

    Nurses\\' knowledge regarding advance directives may affect their administration and completion in end-of-life care. Confidence among nurses is a barrier to the provision of quality end-of-life care. This study investigated nurses\\' knowledge of advance directives and perceived confidence in end-of-life care, in Hong Kong, Ireland, Israel, Italy and the USA using a cross-sectional descriptive design (n = 1089). In all countries, older nurses and those who had more professional experience felt more confident managing patients\\' symptoms at end-of-life and more comfortable stopping preventive medications at end-of-life. Nurses in the USA reported that they have more knowledge and experience of advance directives compared with other countries. In addition, they reported the highest levels of confidence and comfort in dealing with end-of-life care. Although legislation for advance directives does not yet exist in Ireland, nurses reported high levels of confidence in end-of-life care.

  14. Lateral Penumbra Modelling Based Leaf End Shape Optimization for Multileaf Collimator in Radiotherapy

    Directory of Open Access Journals (Sweden)

    Dong Zhou

    2016-01-01

    Full Text Available Lateral penumbra of multileaf collimator plays an important role in radiotherapy treatment planning. Growing evidence has revealed that, for a single-focused multileaf collimator, lateral penumbra width is leaf position dependent and largely attributed to the leaf end shape. In our study, an analytical method for leaf end induced lateral penumbra modelling is formulated using Tangent Secant Theory. Compared with Monte Carlo simulation and ray tracing algorithm, our model serves well the purpose of cost-efficient penumbra evaluation. Leaf ends represented in parametric forms of circular arc, elliptical arc, Bézier curve, and B-spline are implemented. With biobjective function of penumbra mean and variance introduced, genetic algorithm is carried out for approximating the Pareto frontier. Results show that for circular arc leaf end objective function is convex and convergence to optimal solution is guaranteed using gradient based iterative method. It is found that optimal leaf end in the shape of Bézier curve achieves minimal standard deviation, while using B-spline minimum of penumbra mean is obtained. For treatment modalities in clinical application, optimized leaf ends are in close agreement with actual shapes. Taken together, the method that we propose can provide insight into leaf end shape design of multileaf collimator.

  15. Questions and Answers for Transplant Candidates about Model for End-Stage Liver Disease (MELD) and Pediatric End-Stage ....

    Science.gov (United States)

    ... 1 patients have acute (sudden and severe onset) liver failure and a life expectancy of hours to a ... younger are placed in categories according to the Pediatric End-stage Liver Disease (PELD) scoring system. Again there is a ...

  16. Development of a global computable general equilibrium model coupled with detailed energy end-use technology

    International Nuclear Information System (INIS)

    Fujimori, Shinichiro; Masui, Toshihiko; Matsuoka, Yuzuru

    2014-01-01

    Highlights: • Detailed energy end-use technology information is considered within a CGE model. • Aggregated macro results of the detailed model are similar to traditional model. • The detailed model shows unique characteristics in the household sector. - Abstract: A global computable general equilibrium (CGE) model integrating detailed energy end-use technologies is developed in this paper. The paper (1) presents how energy end-use technologies are treated within the model and (2) analyzes the characteristics of the model’s behavior. Energy service demand and end-use technologies are explicitly considered, and the share of technologies is determined by a discrete probabilistic function, namely a Logit function, to meet the energy service demand. Coupling with detailed technology information enables the CGE model to have more realistic representation in the energy consumption. The proposed model in this paper is compared with the aggregated traditional model under the same assumptions in scenarios with and without mitigation roughly consistent with the two degree climate mitigation target. Although the results of aggregated energy supply and greenhouse gas emissions are similar, there are three main differences between the aggregated and the detailed technologies models. First, GDP losses in mitigation scenarios are lower in the detailed technology model (2.8% in 2050) as compared with the aggregated model (3.2%). Second, price elasticity and autonomous energy efficiency improvement are heterogeneous across regions and sectors in the detailed technology model, whereas the traditional aggregated model generally utilizes a single value for each of these variables. Third, the magnitude of emissions reduction and factors (energy intensity and carbon factor reduction) related to climate mitigation also varies among sectors in the detailed technology model. The household sector in the detailed technology model has a relatively higher reduction for both energy

  17. A practice model for rural district nursing success in end-of-life advocacy care.

    Science.gov (United States)

    Reed, Frances M; Fitzgerald, Les; Bish, Melanie R

    2017-08-24

    The development of a practice model for rural district nursing successful end-of-life advocacy care. Resources to help people live well in the end stages of life in rural areas can be limited and difficult to access. District nurse advocacy may promote end-of-life choice for people living at home in rural Australia. The lack of evidence available internationally to inform practice in this context was addressed by exploratory study. A pragmatic mixed method study approved by the University Faculty Ethics Committee and conducted from March 2014 to August 2015 was used to explore the successful end-of-life advocacy of 98 rural Australian district nurses. The findings and results were integrated then compared with theory in this article to develop concepts for a practice model. The model illustrates rural district nurse advocacy success based on respect for the rights and values of people. Advocacy action is motivated by the emotional responses of nurses to the end-of-life vulnerability people experience. The combination of willing investment in relationships, knowing the rural people and resources, and feeling supported, together enables district nurses to develop therapeutic emotional intelligence. This skill promotes moral agency in reflection and advocacy action to overcome emotional and ethical care challenges of access and choice using holistic assessment, communication, organisation of resources and empowering support for the self-determination of person-centred end-of-life goals. Recommendations are proposed from the theoretical concepts in the model. Testing the model in practice is recommended to gain the perceptions of a broader range of rural people both giving and receiving end-of-life-care. A model developed by gathering and comparing district nursing experiences and understanding using mixed methods and existing theory offers evidence for practice of a philosophy of successful person-centred advocacy care in a field of nursing that lacks specific

  18. Wall Correction Model for Wind Tunnels with Open Test Section

    DEFF Research Database (Denmark)

    Sørensen, Jens Nørkær; Shen, Wen Zhong; Mikkelsen, Robert Flemming

    2004-01-01

    In th paper we present a correction model for wall interference on rotors of wind turbines or propellers in wind tunnels. The model, that is based on a onedimensional momentum approach, is validated against results from CFD computations using a generalized actuator disc principle. Generally......, the corrections from the model are in very good agreement with the CFD computaions, demonstrating that one-dimensional momentum theory is a reliable way of predicting corrections for wall interference in wind tunnels with closed as well as open cross sections. Keywords: Wind tunnel correction, momentum theory...

  19. Parallel phase model : a programming model for high-end parallel machines with manycores.

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Junfeng (Syracuse University, Syracuse, NY); Wen, Zhaofang; Heroux, Michael Allen; Brightwell, Ronald Brian

    2009-04-01

    This paper presents a parallel programming model, Parallel Phase Model (PPM), for next-generation high-end parallel machines based on a distributed memory architecture consisting of a networked cluster of nodes with a large number of cores on each node. PPM has a unified high-level programming abstraction that facilitates the design and implementation of parallel algorithms to exploit both the parallelism of the many cores and the parallelism at the cluster level. The programming abstraction will be suitable for expressing both fine-grained and coarse-grained parallelism. It includes a few high-level parallel programming language constructs that can be added as an extension to an existing (sequential or parallel) programming language such as C; and the implementation of PPM also includes a light-weight runtime library that runs on top of an existing network communication software layer (e.g. MPI). Design philosophy of PPM and details of the programming abstraction are also presented. Several unstructured applications that inherently require high-volume random fine-grained data accesses have been implemented in PPM with very promising results.

  20. Optimization of end-members used in multiple linear regression geochemical mixing models

    Science.gov (United States)

    Dunlea, Ann G.; Murray, Richard W.

    2015-11-01

    Tracking marine sediment provenance (e.g., of dust, ash, hydrothermal material, etc.) provides insight into contemporary ocean processes and helps construct paleoceanographic records. In a simple system with only a few end-members that can be easily quantified by a unique chemical or isotopic signal, chemical ratios and normative calculations can help quantify the flux of sediment from the few sources. In a more complex system (e.g., each element comes from multiple sources), more sophisticated mixing models are required. MATLAB codes published in Pisias et al. solidified the foundation for application of a Constrained Least Squares (CLS) multiple linear regression technique that can use many elements and several end-members in a mixing model. However, rigorous sensitivity testing to check the robustness of the CLS model is time and labor intensive. MATLAB codes provided in this paper reduce the time and labor involved and facilitate finding a robust and stable CLS model. By quickly comparing the goodness of fit between thousands of different end-member combinations, users are able to identify trends in the results that reveal the CLS solution uniqueness and the end-member composition precision required for a good fit. Users can also rapidly check that they have the appropriate number and type of end-members in their model. In the end, these codes improve the user's confidence that the final CLS model(s) they select are the most reliable solutions. These advantages are demonstrated by application of the codes in two case studies of well-studied datasets (Nazca Plate and South Pacific Gyre).

  1. Wall correction model for wind tunnels with open test section

    DEFF Research Database (Denmark)

    Sørensen, Jens Nørkær; Shen, Wen Zhong; Mikkelsen, Robert Flemming

    2006-01-01

    In the paper we present a correction model for wall interference on rotors of wind turbines or propellers in wind tunnels. The model, which is based on a one-dimensional momentum approach, is validated against results from CFD computations using a generalized actuator disc principle. In the model...... the exchange of axial momentum between the tunnel and the ambient room is represented by a simple formula, derived from actuator disc computations. The correction model is validated against Navier-Stokes computations of the flow about a wind turbine rotor. Generally, the corrections from the model are in very...... good agreement with the CFD computations, demonstrating that one-dimensional momentum theory is a reliable way of predicting corrections for wall interference in wind tunnels with closed as well as open cross sections....

  2. Estimation of the Human Absorption Cross Section Via Reverberation Models

    DEFF Research Database (Denmark)

    Steinböck, Gerhard; Pedersen, Troels; Fleury, Bernard Henri

    2018-01-01

    and compare the obtained results to those of Sabine's model. We find that the absorption by persons is large enough to be measured with a wideband channel sounder and that estimates of the human absorption cross section differ for the two models. The obtained values are comparable to values reported...... in the literature. We also suggest the use of controlled environments with low average absorption coefficients to obtain more reliable estimates. The obtained values can be used to predict the change of reverberation time with persons in the propagation environment. This allows prediction of channel characteristics...... relevant in communication systems, e.g. path loss and rms delay spread, for various population densities....

  3. Perturbation analysis for Monte Carlo continuous cross section models

    International Nuclear Information System (INIS)

    Kennedy, Chris B.; Abdel-Khalik, Hany S.

    2011-01-01

    Sensitivity analysis, including both its forward and adjoint applications, collectively referred to hereinafter as Perturbation Analysis (PA), is an essential tool to complete Uncertainty Quantification (UQ) and Data Assimilation (DA). PA-assisted UQ and DA have traditionally been carried out for reactor analysis problems using deterministic as opposed to stochastic models for radiation transport. This is because PA requires many model executions to quantify how variations in input data, primarily cross sections, affect variations in model's responses, e.g. detectors readings, flux distribution, multiplication factor, etc. Although stochastic models are often sought for their higher accuracy, their repeated execution is at best computationally expensive and in reality intractable for typical reactor analysis problems involving many input data and output responses. Deterministic methods however achieve computational efficiency needed to carry out the PA analysis by reducing problem dimensionality via various spatial and energy homogenization assumptions. This however introduces modeling error components into the PA results which propagate to the following UQ and DA analyses. The introduced errors are problem specific and therefore are expected to limit the applicability of UQ and DA analyses to reactor systems that satisfy the introduced assumptions. This manuscript introduces a new method to complete PA employing a continuous cross section stochastic model and performed in a computationally efficient manner. If successful, the modeling error components introduced by deterministic methods could be eliminated, thereby allowing for wider applicability of DA and UQ results. Two MCNP models demonstrate the application of the new method - a Critical Pu Sphere (Jezebel), a Pu Fast Metal Array (Russian BR-1). The PA is completed for reaction rate densities, reaction rate ratios, and the multiplication factor. (author)

  4. Self-consisting modeling of entangled network strands and dangling ends

    DEFF Research Database (Denmark)

    Jensen, Mette Krog; Schieber, Jay D.; Khaliullin, Renat N.

    2009-01-01

    Text of Abstract We seek knowledge about the effect of dangling ends and soluble structures of stoichiometrically imbalanced networks. To interpretate our recent experimental results we seek a molecular model that can predict LVE data. The discrete slip-link model (DSM) has proven to be a robust......, we call this an ideal entangled network (IEN). We simulate monodisperse polypropylene oxide with an average number of entanglements of ~3.8. Such lightly entangled networks show a G0 that is about 24% lower than GN0. This decrease is a result of monomer fluctuations between entanglements...... of dangling ends and soluble structures. Energy dissipation is increased by adding a fraction of dangling ends, wDE, to the ensemble. We find that when wDE=0.6, G0 is about 75% lower than GN0, this suggests that the fraction of network strands, wNS=1-wDE, largely influences the plateau value at low...

  5. Surface roughness prediction model in end milling of Al/SiC p MMC ...

    African Journals Online (AJOL)

    This research focuses on study and analyses of surface quality improvement in end milling operation of Al/SiCp metal matrix composite. These materials are selected as they are most widely used in automobile and aerospace industry. This research paper develops an improved mathematical model for surface roughness ...

  6. End-point parametrization and guaranteed stability for a model predictive control scheme

    NARCIS (Netherlands)

    Weiland, Siep; Stoorvogel, Antonie Arij; Tiagounov, Andrei A.

    2001-01-01

    In this paper we consider the closed-loop asymptotic stability of the model predictive control scheme which involves the minimization of a quadratic criterion with a varying weight on the end-point state. In particular, we investigate the stability properties of the (MPC-) controlled system as

  7. An end-to-end coupled model ROMS-N 2 P 2 Z 2 D 2 -OSMOSE of ...

    African Journals Online (AJOL)

    African Journal of Marine Science ... It is linked to the biogeochemical model through the predation process; plankton groups are food for fish and fish apply a predation mortality on plankton. Here we ... Keywords: individual-based model, model validation, pattern-oriented modelling, trophic interactions, two-way coupling

  8. Modeling of end-use properties of poly(propylene/ethylene) resins

    OpenAIRE

    Latado, Andrea; Embiruçu, Marcelo; Mattos Neto, Antônio G.; Pinto, José Carlos

    2001-01-01

    Texto completo: acesso restrito. p. 419–439 The objective of the present work is to develop empirical models to predict end-use properties of poly(ethylene/propylene) resins as functions of more fundamental molecular and morphological properties of the polymer resins. The final properties analyzed are two mechanical properties, rigidity and impact strength, and one thermal property, glass transition temperature. Two additional properties of practical importance are also modeled: the melt i...

  9. Organizational home care models across Europe: A cross sectional study.

    Science.gov (United States)

    Van Eenoo, Liza; van der Roest, Henriëtte; Onder, Graziano; Finne-Soveri, Harriet; Garms-Homolova, Vjenka; Jonsson, Palmi V; Draisma, Stasja; van Hout, Hein; Declercq, Anja

    2018-01-01

    Decision makers are searching for models to redesign home care and to organize health care in a more sustainable way. The aim of this study is to identify and characterize home care models within and across European countries by means of structural characteristics and care processes at the policy and the organization level. At the policy level, variables that reflected variation in health care policy were included based on a literature review on the home care policy for older persons in six European countries: Belgium, Finland, Germany, Iceland, Italy, and the Netherlands. At the organizational level, data on the structural characteristics and the care processes were collected from 36 home care organizations by means of a survey. Data were collected between 2013 and 2015 during the IBenC project. An observational, cross sectional, quantitative design was used. The analyses consisted of a principal component analysis followed by a hierarchical cluster analysis. Fifteen variables at the organizational level, spread across three components, explained 75.4% of the total variance. The three components made it possible to distribute home care organizations into six care models that differ on the level of patient-centered care delivery, the availability of specialized care professionals, and the level of monitoring care performance. Policy level variables did not contribute to distinguishing between home care models. Six home care models were identified and characterized. These models can be used to describe best practices. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Association of office-based frailty score with hypertensive end organ damage in the J-SHIPP cross-sectional study.

    Science.gov (United States)

    Tabara, Yasuharu; Kohara, Katsuhiko; Ochi, Masayuki; Okada, Yoko; Ohara, Maya; Nagai, Tokihisa; Igase, Michiya

    2016-08-01

    Frailty, a geriatric syndrome reflecting a state of reduced physiological reserve and increased vulnerability, is an independent risk factor for cardiovascular morbidity and mortality. However, the relationship between frailty and hypertensive end-organ damage is not fully established. We performed a cross-sectional study to investigate the association between frailty and end-organ damage in 1125 apparently healthy middle-aged to elderly subjects. We performed a simple frailty (SF) score that was easily obtainable in the office, in combination with low hand grip power and short one-leg standing (OLS) time. The association between SF score and hypertensive end-organ damage and other frailty-related parameters was evaluated. Odds ratio of SF score 1 to score 0 for the presence of hypertension was 1.9 [1.4-2.5, p<.0001] and that of SF score 2 was 3.3 [2.1-5.3, p<.0001]. SF score was also significantly associated with brachial-ankle pulse wave velocity (baPWV) and central pulse pressure (PP2). SF score was significantly associated with higher frailty index calculated from 21 parameters, lower cognitive test score, % vital capacity, skeletal muscle mass, and thigh muscle cross-sectional area. SF score was positively associated with stage of brain white matter hyperintenisty, plasma levels of B-type natriuretic peptide, and urinary protein excretion, even after correction for confounding parameters including baPWV and PP2. These findings indicate that frailty is significantly associated with end-organ damage in elderly subjects. SF score may be a useful clinical tool to identify frail subjects and advanced end-organ damage in elderly subjects. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  11. Peningkatan Kemampuan Pemecahan Masalah dan Komunikasi Matematis Siswa SMP melalui Model Pembelajaran Means-ends Analysis

    Directory of Open Access Journals (Sweden)

    Juanda Juanda

    2014-12-01

    Full Text Available Dalam kurikulum mata pelajaran matematika, siswa dituntut mampu mengembangkan kemampuan matematika dalam pemecahan masalah dan mengkomunikasikan ide atau gagasan dengan menggunakan simbol, tabel, diagram, dan media lain. Oleh karena itu, dibutuhkan model pembelajaran yang tepat untuk meningkatkan kemampuan pemecahan masalah dan komunikasi matematis. Penelitian ini bertujuan untuk; 1 mengetahui peningkatan kemampuan pemecahan masalah dan komunikasi matematis apabila ditinjau keseluruhan siswa dan level kemampuan awal siswa, 2 interaksi antara model pembelajaran dan level kemampuan siswa terhadap peningkatan kemampuan pemecahan masalah dan komunikasi matematis dan 3 sikap siswa terhadap pembelajaran model Means-ends analysis. Penelitian ini menggunakan pendekatan kuantitatif dengan metode eksperimen. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMPS YPPU Sigli, Provinsi Aceh, sedangkan sampelnya adalah siswa kelas VIII-1 sebagai kelas eksperimen dan kelas VIII-2 sebagai kelas kontrol. Instrumen yang digunakan adalah jenis tes dan non tes. Analisis data dilakukan secara kuantitatif dengan menggunakan uji-t terhadap rataan gain ternormalisasi antara kedua kelompok sampel  dan uji anova dua jalur untuk menguji interaksi antara model pembelajaran dan level siswa terhadap peningkatan kemampuan matematis siswa. Hasil penelitian menyimpulkan bahwa peningkatan kemampuan pemecahan masalah dan komunikasi matematis siswa yang memperoleh pembelajaran model Means-ends analysis lebih baik daripada siswa yang memperoleh pembelajaran konvensional baik ditinjau berdasarkan keseluruhan siswa maupun berdasarkan level kemampuan siswa. Terdapat interaksi antara faktor model pembelajaran dan level kemampuan siswa terhadap peningkatan kemampuan pemecahan masalah matematis. Tidak terdapat interaksi antara model pembelajaran Means-ends analysis dan level kemampuan siswa terhadap peningkatan kemampuan komunikasi matematis. Siswa memiliki sikap positif

  12. Application of nuclear models to neutron nuclear cross section calculations

    International Nuclear Information System (INIS)

    Young, P.G.

    1983-01-01

    Nuclear theory is used increasingly to supplement and extend the nuclear data base that is available for applied studies. Areas where theoretical calculations are most important include the determination of neutron cross sections for unstable fission products and transactinide nuclei in fission reactor or nuclear waste calculations and for meeting the extensive dosimetry, activation, and neutronic data needs associated with fusion reactor development, especially for neutron energies above 14 MeV. Considerable progress has been made in the use of nuclear models for data evaluation and, particularly, in the methods used to derive physically meaningful parameters for model calculations. Theoretical studies frequently involve use of spherical and deformed optical models, Hauser-Feshbach statistical theory, preequilibrium theory, direct-reaction theory and often make use of gamma-ray strength function models and phenomenological (or microscopic) level density prescriptions. The development, application and limitations of nuclear models for data evaluation are discussed in this paper, with emphasis on the 0.1 to 50 MeV energy range. (Auth.)

  13. A study of pulmonary function in end-stage renal disease patients on hemodialysis: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Ashima Sharma

    Full Text Available ABSTRACT BACKGROUND: The aim here was to study acute effects of hemodialysis among end-stage renal disease (ESRD patients. DESIGN AND SETTING: Prospective study in tertiary-level care center. METHODS: Fifty ESRD patients undergoing hemodialysis were studied. Spirometric pulmonary function tests were performed before and after four-hour hemodialysis sessions. RESULTS: The patients’ average age was 45.8 ± 10.0 years; 64% were males and 64% had normal body mass index. Anemia (94% and hypoalbuminemia (72% were common. Diabetes mellitus (68%, hypertension (34% and coronary artery disease (18% were major comorbidities. Forty-five patients (90% had been on hemodialysis for six months to three years. The patients’ pre-dialysis mean forced vital capacity (FVC and forced expiratory volume in 1 second (FEV1 were below normal: 45.8 ± 24.9% and 43.5 ± 25.9% of predicted, respectively. After hemodialysis, these increased significantly, to 51.1 ± 23.4% and 49.3 ± 25.5% of predicted, respectively (P 0.05. The pre-dialysis mean forced expiratory flow 25-75% was 50.1 ± 31% and increased significantly, to 56.3 ± 31.6% of predicted (P < 0.05. The mean peak expiratory flow was below normal (43.8 ± 30.7% and increased significantly, to 49.1 ± 29.9% of predicted (P < 0.05. Males and females showed similar directions of change after hemodialysis. CONCLUSIONS: Pulmonary function abnormalities are common among ESRD patients. Comparison of pre and post-hemodialysis parameters showed significant improvements, but normal predicted values were still not achieved.

  14. Association Between Accumulation of Advanced Glycation End-Products and Hearing Impairment in Community-Dwelling Older People: A Cross-Sectional Sukagawa Study.

    Science.gov (United States)

    Niihata, Kakuya; Takahashi, Sei; Kurita, Noriaki; Yajima, Nobuyuki; Omae, Kenji; Fukuma, Shingo; Okano, Takayuki; Nomoto, Yukio; Omori, Koichi; Fukuhara, Shunichi

    2018-03-01

    The experimental studies suggested the hypothesis that the accumulation of advanced glycation end-products (AGEs) could induce hearing impairment. The purpose of this study is to examine the hypothesis among elderly people using an epidemiologic approach. Cross-sectional study. Sukagawa City, Fukushima, Japan. A total of 270 residents aged 75 years or over without dementia, who participated in a health check-up conducted in 2015. The exposure variable was AGEs, which was assessed using skin autofluorescence (AF) as a proxy measure. The primary outcome was moderate hearing impairment or worse, which was defined as a pure tone average of thresholds ≥41 decibel hearing level at 0.5, 1, 2, and 4 kHz in the better-hearing ear. The secondary outcome was the pure tone average of thresholds as a continuous variable. We estimated the odds ratio using a logistic regression model for the primary outcome and a general linear model for the mean difference in the pure tone average of thresholds for the secondary outcome. Both models were adjusted for relevant confounding factors: age, sex, smoking, diabetes, hypertension, and history of cerebrovascular diseases. The median (interquartile range) AF was 2.2 (2.0, 2.5) arbitrary units (AU). Moderate hearing impairment was reported in 88 participants (32.6%). For the primary outcome, we found significant associations between moderate hearing impairment and AF (adjusted odds ratio per 1 AU, 2.60; 95% confidence interval 1.26-5.35). For the secondary outcome, we also found a significant association between a 1-AU increase in AF and increased pure tone average, with a difference (6.52 dB per 1 AU; 95% confidence interval 2.18-10.86) comparable in magnitude to the increase in pure tone average observed for a 6-year increase in age in our population. Our study indicated that high levels of AGEs were independently associated with hearing impairment. Modifying levels of AGEs may prevent hearing impairment. Copyright © 2017 AMDA

  15. Learning end-of-life care within a constructivist model: Undergraduate nursing students’ experiences

    Directory of Open Access Journals (Sweden)

    Anna E. van der Wath

    2015-11-01

    Full Text Available Background: Although nursing education aims to equip nursing students to provide care to dying patients and their families, nurses often feel ill-prepared to cope with the emotional labour involved in end-of-life care. Objectives: The aim of the study was to explore and describe nursing students’ experiences of end-of-life care through experiential learning within a constructivist educational model. Method: A qualitative, descriptive design was used. As part of introducing experiential learning, innovative educational practices were initiated during a second year level undergraduate nursing module on end-of-life care. Qualitative data on second-year nursing students’ experiences were collected through written reflections and analysed using open coding. Results: The themes that emerged revealed participants’ sensory and emotional experiences during the learning opportunities. Participants reflected on what they learnt and clarified their values related to death and dying. They indicated how they would apply the new meanings constructed in clinical practice. Conclusion: A constructivist educational model of experiential learning holds potential to enhance value clarification and nursing students’ sensory and emotional awareness of death and dying. Experiential learning is recommended to develop nursing students’ competency inproviding end-of-life care.

  16. Bridging Automatic Speech Recognition and Psycholinguistics: Extending Shortlist to an End-to-End Model of Human Speech Recognition

    NARCIS (Netherlands)

    Scharenborg, O.E.; Bosch, L.F.M. ten; Boves, L.W.J.; Norris, D.

    2003-01-01

    This letter evaluates potential benefits of combining human speech recognition (HSR) and automatic speech recognition by building a joint model of an automatic phone recognizer (APR) and a computational model of HSR, viz. Shortlist (Norris, 1994). Experiments based on 'real-life' speech highlight

  17. Bridging automatic speech recognition and psycholinguistics: Extending Shortlist to an end-to-end model of human speech recognition (L)

    Science.gov (United States)

    Scharenborg, Odette; ten Bosch, Louis; Boves, Lou; Norris, Dennis

    2003-12-01

    This letter evaluates potential benefits of combining human speech recognition (HSR) and automatic speech recognition by building a joint model of an automatic phone recognizer (APR) and a computational model of HSR, viz., Shortlist [Norris, Cognition 52, 189-234 (1994)]. Experiments based on ``real-life'' speech highlight critical limitations posed by some of the simplifying assumptions made in models of human speech recognition. These limitations could be overcome by avoiding hard phone decisions at the output side of the APR, and by using a match between the input and the internal lexicon that flexibly copes with deviations from canonical phonemic representations.

  18. Piecewise Function Hysteretic Model for Cold-Formed Steel Shear Walls with Reinforced End Studs

    Directory of Open Access Journals (Sweden)

    Jihong Ye

    2017-01-01

    Full Text Available Cold-formed steel (CFS shear walls with concrete-filled rectangular steel tube (CFRST columns as end studs can upgrade the performance of mid-rise CFS structures, such as the vertical bearing capacity, anti-overturning ability, shear strength, and fire resistance properties, thereby enhancing the safety of structures. A theoretical hysteretic model is established according to a previous experimental study. This model is described in a simple mathematical form and takes nonlinearity, pinching, strength, and stiffness deterioration into consideration. It was established in two steps: (1 a discrete coordinate method was proposed to determine the load-displacement skeleton curve of the wall, by which governing deformations and their corresponding loads of the hysteretic loops under different loading cases can be obtained; afterwards; (2 a piecewise function was adopted to capture the hysteretic loop relative to each governing deformation, the hysteretic model of the wall was further established, and additional criteria for the dominant parameters of the model were stated. Finally, the hysteretic model was validated by experimental results from other studies. The results show that elastic lateral stiffness Ke and shear capacity Fp are key factors determining the load-displacement skeleton curve of the wall; hysteretic characteristics of the wall with reinforced end studs can be fully reflected by piecewise function hysteretic model, moreover, the model has intuitional expressions with clear physical interpretations for each parameter, paving the way for predicting the nonlinear dynamic responses of mid-rise CFS structures.

  19. Means-End based Functional Modeling for Intelligent Control: Modeling and Experiments with an Industrial Heat Pump System

    DEFF Research Database (Denmark)

    Saleem, Arshad

    2007-01-01

    The purpose of this paper is to present a Multilevel Flow Model (MFM) of an industrial heat pump system and its use for diagnostic reasoning. MFM is functional modeling language supporting an explicit means-ends intelligent control strategy for large industrial process plants. The model is used...... in several diagnostic experiments analyzing different fault scenarios. The model and results of the experiments are explained and it is shown how MFM based intelligent modeling and automated reasoning can improve the fault diagnosis process significantly....

  20. Analytical thermal model for end-pumped solid-state lasers

    Science.gov (United States)

    Cini, L.; Mackenzie, J. I.

    2017-12-01

    Fundamentally power-limited by thermal effects, the design challenge for end-pumped "bulk" solid-state lasers depends upon knowledge of the temperature gradients within the gain medium. We have developed analytical expressions that can be used to model the temperature distribution and thermal-lens power in end-pumped solid-state lasers. Enabled by the inclusion of a temperature-dependent thermal conductivity, applicable from cryogenic to elevated temperatures, typical pumping distributions are explored and the results compared with accepted models. Key insights are gained through these analytical expressions, such as the dependence of the peak temperature rise in function of the boundary thermal conductance to the heat sink. Our generalized expressions provide simple and time-efficient tools for parametric optimization of the heat distribution in the gain medium based upon the material and pumping constraints.

  1. Mixed integer nonlinear programming model of wireless pricing scheme with QoS attribute of bandwidth and end-to-end delay

    Science.gov (United States)

    Irmeilyana, Puspita, Fitri Maya; Indrawati

    2016-02-01

    The pricing for wireless networks is developed by considering linearity factors, elasticity price and price factors. Mixed Integer Nonlinear Programming of wireless pricing model is proposed as the nonlinear programming problem that can be solved optimally using LINGO 13.0. The solutions are expected to give some information about the connections between the acceptance factor and the price. Previous model worked on the model that focuses on bandwidth as the QoS attribute. The models attempt to maximize the total price for a connection based on QoS parameter. The QoS attributes used will be the bandwidth and the end to end delay that affect the traffic. The maximum goal to maximum price is achieved when the provider determine the requirement for the increment or decrement of price change due to QoS change and amount of QoS value.

  2. Safety and effectiveness of alveolar recruitment maneuvers and positive end-expiratory pressure during general anesthesia for cesarean section: a prospective, randomized trial.

    Science.gov (United States)

    Aretha, D; Fligou, F; Kiekkas, P; Messini, C; Panteli, E; Zintzaras, E; Karanikolas, M

    2017-05-01

    During cesarean section, the supine position reduces functional residual capacity and worsens lung compliance. We tested the hypothesis that alveolar recruitment maneuvers and positive end-expiratory pressure improve lung compliance in women undergoing general anesthesia for cesarean section. Ninety women undergoing cesarean section were randomly assigned to one of two groups in a prospective, double-blind trial. In the alveolar recruitment maneuver group, pressure-control ventilation was used and inspiratory time was increased to 50% after delivery; positive end-expiratory pressure was increased to 20cmH 2 O and peak airway inspiratory pressure gradually increased to 45-50cmH 2 O. Volume-control ventilation was then used with low tidal volumes (6mL/kg) and positive end-expiratory pressure was reduced stepwise to 8cmH 2 O. In the control group, alveolar recruitment maneuvers were not used. Data were collected before and 3, 10 and 20min after the alveolar recruitment maneuver, before extubation and postoperatively at 10 and 20min. Dynamic compliance, peak airway inspiratory pressure, PaO 2 and PaO 2 /FiO 2 were significantly different in the alveolar recruitment maneuver group compared to controls at all time points during surgery except at baseline. Oxygen saturation was significantly greater in the alveolar recruitment maneuver group at 10 and 20min and before extubation. Dynamic compliance was 29.7-42.5% higher and peak airway inspiratory pressure 3.6-10.2% lower in the alveolar recruitment maneuver group compared to controls. The PaO 2 , PaO 2 /FiO 2 and oxygen saturation were higher (9.4-12%, 10.3-11.9% and 0.4-1.3%, respectively) in the alveolar recruitment maneuver group. Postoperatively, PaO 2 and oxygen saturation were significantly higher in the alveolar recruitment maneuver group compared to controls (PaO 2 9.2% at 10min and 8.4% at 20min, oxygen saturation 0.8% at 10min and 1.1% at 20min). There were no significant differences in hemodynamic stability or

  3. Photo-neutron reaction cross-section for 93Nb in the end-point bremsstrahlung energies of 12–16 and 45–70 MeV

    International Nuclear Information System (INIS)

    Naik, H.; Kim, G.N.; Schwengner, R.; Kim, K.; Zaman, M.; Tatari, M.; Sahid, M.; Yang, S.C.; John, R.; Massarczyk, R.; Junghans, A.; Shin, S.G.; Key, Y.; Wagner, A.; Lee, M.W.; Goswami, A.; Cho, M.-H.

    2013-01-01

    The photo-neutron cross-sections of 93 Nb at the end-point bremsstrahlung energies of 12, 14 and 16 MeV as well as 45, 50, 55, 60 and 70 MeV have been determined by the activation and the off-line γ-ray spectrometric techniques using the 20 MeV electron linac (ELBE) at Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany, and 100 MeV electron linac at Pohang Accelerator Laboratory (PAL), Pohang, Korea. The 93 Nb(γ, xn, x=1–4) reaction cross-sections as a function of photon energy were also calculated using computer code TALYS 1.4. The flux-weighted average values were obtained from the experimental and the theoretical (TALYS) values based on mono-energetic photons. The experimental values of present work are in good agreement with the flux-weighted theoretical values of TALYS 1.4 but are slightly higher than the flux-weighted experimental data of mono-energetic photons. It was also found that the theoretical and the experimental values of present work and literature data for the 93 Nb(γ, xn) reaction cross-sections increase from the threshold values to a certain energy, where other reaction channels opens. However, the increase of 93 Nb(γ, n) and 93 Nb(γ, 2n) reaction cross-sections are sharper compared to 93 Nb(γ, 3n) and 93 Nb(γ, 4n) reaction cross-sections. The sharp increase of 93 Nb(γ, n) and 93 Nb(γ, 2n) reaction cross-sections from the threshold value up to 17–22 MeV is due to the Giant Dipole Resonance (GDR) effect besides the role of excitation energy. After a certain values, the individual 93 Nb(γ, xn) reaction cross-sections decrease with increase of bremsstrahlung energy due to opening of other reaction channels

  4. Model microswimmers in channels with varying cross section

    Science.gov (United States)

    Malgaretti, Paolo; Stark, Holger

    2017-05-01

    We study different types of microswimmers moving in channels with varying cross section and thereby interacting hydrodynamically with the channel walls. Starting from the Smoluchowski equation for a dilute suspension, for which interactions among swimmers can be neglected, we derive analytic expressions for the lateral probability distribution between plane channel walls. For weakly corrugated channels, we extend the Fick-Jacobs approach to microswimmers and thereby derive an effective equation for the probability distribution along the channel axis. Two regimes arise dominated either by entropic forces due to the geometrical confinement or by the active motion. In particular, our results show that the accumulation of microswimmers at channel walls is sensitive to both the underlying swimming mechanism and the geometry of the channels. Finally, for asymmetric channel corrugation, our model predicts a rectification of microswimmers along the channel, the strength and direction of which strongly depends on the swimmer type.

  5. Viable inflationary models ending with a first-order phase transition

    International Nuclear Information System (INIS)

    Cortes, Marina; Liddle, Andrew R.

    2009-01-01

    We investigate the parameter space of two-field inflation models where inflation terminates via a first-order phase transition causing nucleation of bubbles. Such models experience a tension from the need to ensure nearly scale-invariant density perturbations, while avoiding a near scale-invariant bubble size distribution which would conflict observations. We perform an exact analysis of the different regimes of the models, where the energy density of the inflaton field ranges from being negligible as compared to the vacuum energy to providing most of the energy for inflation. Despite recent microwave anisotropy results favoring a spectral index less than 1, we find that there are still viable models that end with bubble production and can match all available observations. As a by-product of our analysis, we also provide an up-to-date assessment of the viable parameter space of Linde's original second-order hybrid model across its full parameter range.

  6. Lake Representations in Global Climate Models: An End-User Perspective

    Science.gov (United States)

    Rood, R. B.; Briley, L.; Steiner, A.; Wells, K.

    2017-12-01

    The weather and climate in the Great Lakes region of the United States and Canada are strongly influenced by the lakes. Within global climate models, lakes are incorporated in many ways. If one is interested in quantitative climate information for the Great Lakes, then it is a first principle requirement that end-users of climate model simulation data, whether scientists or practitioners, need to know if and how lakes are incorporated into models. We pose the basic question, how are lakes represented in CMIP models? Despite significant efforts by the climate community to document and publish basic information about climate models, it is unclear how to answer the question about lake representations? With significant knowledge of the practice of the field, then a reasonable starting point is to use the ES-DOC Comparator (https://compare.es-doc.org/ ). Once at this interface to model information, the end-user is faced with the need for more knowledge about the practice and culture of the discipline. For example, lakes are often categorized as a type of land, a counterintuitive concept. In some models, though, lakes are specified in ocean models. There is little evidence and little confidence that the information obtained through this process is complete or accurate. In fact, it is verifiably not accurate. This experience, then, motivates identifying and finding either human experts or technical documentation for each model. The conclusion from this exercise is that it can take months or longer to provide a defensible answer to if and how lakes are represented in climate models. Our experience with lake finding is that this is not a unique experience. This talk documents our experience and explores barriers we have identified and strategies for reducing those barriers.

  7. Applications of the SWAT Model Special Section: Overview and Insights.

    Science.gov (United States)

    Gassman, Philip W; Sadeghi, Ali M; Srinivasan, Raghavan

    2014-01-01

    The Soil and Water Assessment Tool (SWAT) model has emerged as one of the most widely used water quality watershed- and river basin-scale models worldwide, applied extensively for a broad range of hydrologic and/or environmental problems. The international use of SWAT can be attributed to its flexibility in addressing water resource problems, extensive networking via dozens of training workshops and the several international conferences that have been held during the past decade, comprehensive online documentation and supporting software, and an open source code that can be adapted by model users for specific application needs. The catalyst for this special collection of papers was the 2011 International SWAT Conference & Workshops held in Toledo, Spain, which featured over 160 scientific presentations representing SWAT applications in 37 countries. This special collection presents 22 specific SWAT-related studies, most of which were presented at the 2011 SWAT Conference; it represents SWAT applications on five different continents, with the majority of studies being conducted in Europe and North America. The papers cover a variety of topics, including hydrologic testing at a wide range of watershed scales, transport of pollutants in northern European lowland watersheds, data input and routing method effects on sediment transport, development and testing of potential new model algorithms, and description and testing of supporting software. In this introduction to the special section, we provide a synthesis of these studies within four main categories: (i) hydrologic foundations, (ii) sediment transport and routing analyses, (iii) nutrient and pesticide transport, and (iv) scenario analyses. We conclude with a brief summary of key SWAT research and development needs. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  8. QSAR modeling of cumulative environmental end-points for the prioritization of hazardous chemicals.

    Science.gov (United States)

    Gramatica, Paola; Papa, Ester; Sangion, Alessandro

    2018-01-24

    The hazard of chemicals in the environment is inherently related to the molecular structure and derives simultaneously from various chemical properties/activities/reactivities. Models based on Quantitative Structure Activity Relationships (QSARs) are useful to screen, rank and prioritize chemicals that may have an adverse impact on humans and the environment. This paper reviews a selection of QSAR models (based on theoretical molecular descriptors) developed for cumulative multivariate endpoints, which were derived by mathematical combination of multiple effects and properties. The cumulative end-points provide an integrated holistic point of view to address environmentally relevant properties of chemicals.

  9. End-of-Discharge and End-of-Life Prediction in Lithium-Ion Batteries with Electrochemistry-Based Aging Models

    Science.gov (United States)

    Daigle, Matthew; Kulkarni, Chetan S.

    2016-01-01

    As batteries become increasingly prevalent in complex systems such as aircraft and electric cars, monitoring and predicting battery state of charge and state of health becomes critical. In order to accurately predict the remaining battery power to support system operations for informed operational decision-making, age-dependent changes in dynamics must be accounted for. Using an electrochemistry-based model, we investigate how key parameters of the battery change as aging occurs, and develop models to describe aging through these key parameters. Using these models, we demonstrate how we can (i) accurately predict end-of-discharge for aged batteries, and (ii) predict the end-of-life of a battery as a function of anticipated usage. The approach is validated through an experimental set of randomized discharge profiles.

  10. AN OPTIMIZATION MODEL TO MINIMIZE THE EXPECTED END-TO-END TRANSMISSION TIME IN WIRELESS MESH NETWORKS

    Directory of Open Access Journals (Sweden)

    Marlon da Silva

    Full Text Available ABSTRACT Time metrics are extremely important to evaluate the transmission performance on Wireless Mesh Networks (WMNs, whose main characteristic is to use multihop technology to extend the network coverage area. One of such metrics is WCETT (Weighted Cumulative Expected Transmission Time, in which transmission times per hop are weighted for both proactive and reactive conditions. Furthermore, such metrics are able to detect delays that can degrade some network services. This paper presents an optimization model to minimize WCETT in a WMN, subject to constraints grouped by bandwidth, flow control and power control. As the model includes nonlinear constraints, we propose a heuristic to solve it, which divides the problem in two subproblems. The first subproblem maximizes the network link capacity and a Simulated Annealing algorithm is used to solve it. Considering the link capacities obtained, the second subproblem minimizes the WCETTs, which is formulated as a linear programming model. Some numerical results are presented, based on instances of WMNs randomly generated. Some of these results are compared with the results obtained by a commercial simulator in order to verify the coherence of the proposed heuristic for realistic scenarios.

  11. Mixtures of endocrine disrupting contaminants modelled on human high end exposures

    DEFF Research Database (Denmark)

    Christiansen, Sofie; Kortenkamp, A.; Petersen, Marta Axelstad

    2012-01-01

    though each individual chemical is present at low, ineffective doses, but the effects of mixtures modelled based on human intakes have not previously been investigated. To address this issue for the first time, we selected 13 chemicals for a developmental mixture toxicity study in rats where data about...... in vivo endocrine disrupting effects and information about human exposures was available, including phthalates, pesticides, UV‐filters, bisphenol A, parabens and the drug paracetamol. The mixture ratio was chosen to reflect high end human intakes. To make decisions about the dose levels for studies...... in the rat, we employed the point of departure index (PODI) approach, which sums up ratios between estimated exposure levels and no‐observed‐adverse‐effect‐level (NOAEL) values of individual substances. For high end human exposures to the 13 selected chemicals, we calculated a PODI of 0.016. As only a PODI...

  12. Predictive Surface Roughness Model for End Milling of Machinable Glass Ceramic

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, M Mohan; Gorin, Alexander [School of Engineering and Science, Curtin University of Technology, Sarawak (Malaysia); Abou-El-Hossein, K A, E-mail: mohan.m@curtin.edu.my [Mechanical and Aeronautical Department, Nelson Mandela Metropolitan University, Port Elegebeth, 6031 (South Africa)

    2011-02-15

    Advanced ceramics of Machinable glass ceramic is attractive material to produce high accuracy miniaturized components for many applications in various industries such as aerospace, electronics, biomedical, automotive and environmental communications due to their wear resistance, high hardness, high compressive strength, good corrosion resistance and excellent high temperature properties. Many research works have been conducted in the last few years to investigate the performance of different machining operations when processing various advanced ceramics. Micro end-milling is one of the machining methods to meet the demand of micro parts. Selecting proper machining parameters are important to obtain good surface finish during machining of Machinable glass ceramic. Therefore, this paper describes the development of predictive model for the surface roughness of Machinable glass ceramic in terms of speed, feed rate by using micro end-milling operation.

  13. Predictive Surface Roughness Model for End Milling of Machinable Glass Ceramic

    International Nuclear Information System (INIS)

    Reddy, M Mohan; Gorin, Alexander; Abou-El-Hossein, K A

    2011-01-01

    Advanced ceramics of Machinable glass ceramic is attractive material to produce high accuracy miniaturized components for many applications in various industries such as aerospace, electronics, biomedical, automotive and environmental communications due to their wear resistance, high hardness, high compressive strength, good corrosion resistance and excellent high temperature properties. Many research works have been conducted in the last few years to investigate the performance of different machining operations when processing various advanced ceramics. Micro end-milling is one of the machining methods to meet the demand of micro parts. Selecting proper machining parameters are important to obtain good surface finish during machining of Machinable glass ceramic. Therefore, this paper describes the development of predictive model for the surface roughness of Machinable glass ceramic in terms of speed, feed rate by using micro end-milling operation.

  14. End to End Travel

    Data.gov (United States)

    US Agency for International Development — E2 Solutions is a web based end-to-end travel management tool that includes paperless travel authorization and voucher document submissions, document approval...

  15. Biomethane storage: Evaluation of technologies, end uses, business models, and sustainability

    International Nuclear Information System (INIS)

    Budzianowski, Wojciech M.; Brodacka, Marlena

    2017-01-01

    Highlights: • Biomethane storage integrates the different energy subsystems. • It facilitates adoption of solar and wind energy sources. • It is essential to adequately match storages with their end uses and business models. • Business models must propose, create, and capture value linked with gas storage. • Sustainable is economically viable, environmentally benign, and socially beneficial. - Abstract: Biomethane is a renewable gas that can be turned into dispatchable resource through applying storage techniques. The storage enables the discharge of stored biomethane at any time and place it is required as gas turbine power, heat or transport fuel. Thus the stored biomethane could more efficiently serve various energy applications in the power, transport, heat, and gas systems as well as in industry. Biomethane storage may therefore integrate the different energy subsystems making the whole energy system more efficient. This work provides an overview and evaluation of biomethane storage technologies, end uses, business models and sustainability. It is shown that storage technologies are versatile, have different costs and efficiencies and may serve different end uses. Business models may be created or selected to fit regional spatial contexts, realistic demands for gas storage related services, and the level of available subsidies. By applying storage the sustainability of biomethane is greatly improved in terms of economic viability, reduced environmental impacts and greater social benefits. Stored biomethane may greatly facilitate adoption of intermittent renewable energy sources such as solar and wind. Other findings show that biomethane storage needs to be combined with grid services and other similar services to reduce overall storage costs.

  16. Demonstration of a fully-coupled end-to-end model for small pelagic fish using sardine and anchovy in the California Current

    Science.gov (United States)

    Rose, Kenneth A.; Fiechter, Jerome; Curchitser, Enrique N.; Hedstrom, Kate; Bernal, Miguel; Creekmore, Sean; Haynie, Alan; Ito, Shin-ichi; Lluch-Cota, Salvador; Megrey, Bernard A.; Edwards, Chris A.; Checkley, Dave; Koslow, Tony; McClatchie, Sam; Werner, Francisco; MacCall, Alec; Agostini, Vera

    2015-11-01

    We describe and document an end-to-end model of anchovy and sardine population dynamics in the California Current as a proof of principle that such coupled models can be developed and implemented. The end-to-end model is 3-dimensional, time-varying, and multispecies, and consists of four coupled submodels: hydrodynamics, Eulerian nutrient-phytoplankton-zooplankton (NPZ), an individual-based full life cycle anchovy and sardine submodel, and an agent-based fishing fleet submodel. A predator roughly mimicking albacore was included as individuals that consumed anchovy and sardine. All submodels were coded within the ROMS open-source community model, and used the same resolution spatial grid and were all solved simultaneously to allow for possible feedbacks among the submodels. We used a super-individual approach and solved the coupled models on a distributed memory parallel computer, both of which created challenging but resolvable bookkeeping challenges. The anchovy and sardine growth, mortality, reproduction, and movement, and the fishing fleet submodel, were each calibrated using simplified grids before being inserted into the full end-to-end model. An historical simulation of 1959-2008 was performed, and the latter 45 years analyzed. Sea surface height (SSH) and sea surface temperature (SST) for the historical simulation showed strong horizontal gradients and multi-year scale temporal oscillations related to various climate indices (PDO, NPGO), and both showed responses to ENSO variability. Simulated total phytoplankton was lower during strong El Nino events and higher for the strong 1999 La Nina event. The three zooplankton groups generally corresponded to the spatial and temporal variation in simulated total phytoplankton. Simulated biomasses of anchovy and sardine were within the historical range of observed biomasses but predicted biomasses showed much less inter-annual variation. Anomalies of annual biomasses of anchovy and sardine showed a switch in the mid

  17. Team-Based Models for End-of-Life Care: An Evidence-Based Analysis

    Science.gov (United States)

    2014-01-01

    Background End of life refers to the period when people are living with advanced illness that will not stabilize and from which they will not recover and will eventually die. It is not limited to the period immediately before death. Multiple services are required to support people and their families during this time period. The model of care used to deliver these services can affect the quality of the care they receive. Objectives Our objective was to determine whether an optimal team-based model of care exists for service delivery at end of life. In systematically reviewing such models, we considered their core components: team membership, services offered, modes of patient contact, and setting. Data Sources A literature search was performed on October 14, 2013, using Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid Embase, EBSCO Cumulative Index to Nursing & Allied Health Literature (CINAHL), and EBM Reviews, for studies published from January 1, 2000, to October 14, 2013. Review Methods Abstracts were reviewed by a single reviewer and full-text articles were obtained that met the inclusion criteria. Studies were included if they evaluated a team model of care compared with usual care in an end-of-life adult population. A team was defined as having at least 2 health care disciplines represented. Studies were limited to English publications. A meta-analysis was completed to obtain pooled effect estimates where data permitted. The GRADE quality of the evidence was evaluated. Results Our literature search located 10 randomized controlled trials which, among them, evaluated the following 6 team-based models of care: hospital, direct contact home, direct contact home, indirect contact comprehensive, indirect contact comprehensive, direct contact comprehensive, direct, and early contact Direct contact is when team members see the patient; indirect contact is when they advise another health care practitioner (e.g., a family doctor) who sees

  18. A Three End-Member Mixing Model Based on Isotopic Composition and Elemental Ratio

    Directory of Open Access Journals (Sweden)

    Kon-Kee Liu Shuh-Ji Kao

    2007-01-01

    Full Text Available A three end-member mixing model based on nitrogen isotopic composition and organic carbon to nitrogen ratio of suspended particulate matter in an aquatic environment has been developed. Mathematical expressions have been derived for the calculation of the fractions of nitrogen or organic carbon originating from three different sources of distinct isotopic and elemental compositions. The model was successfully applied to determine the contributions from anthropogenic wastes, soils and bedrock-derived sediments to particulate nitrogen and particulate organic carbon in the Danshuei River during the flood caused by Typhoon Bilis in August 2000. The model solutions have been expressed in a general form that allows applications to mixtures with other types of isotopic compositions and elemental ratios or in forms other than suspended particulate matter.

  19. Older Adults Making End of Life Decisions: An Application of Roy's Adaptation Model

    Directory of Open Access Journals (Sweden)

    Weihua Zhang

    2013-01-01

    Full Text Available Purpose. The purpose of this study was to identify variables that influenced completion of advanced directives in the context of adaptation from national data in older adults. Knowledge gained from this study would help us identify factors that might influence end of life discussions and shed light on strategies on effective communication on advance care planning. Design and Method. A model-testing design and path analysis were used to examine secondary data from 938 participants. Items were extracted from the data set to correspond to variables for this study. Scales were constructed and reliabilities were tested. Results. The final path model showed that physical impairment, self-rated health, continuing to work, and family structure had direct and indirect effects on completion of advanced directives. Five percent of the variance was accounted for by the path analysis. Conclusion. The variance accounted for by the model was small. This could have been due to the use of secondary data and limitations imposed for measurement. However, health care providers and families should explore patient’s perception of self-health as well as their family and work situation in order to strategize a motivational discussion on advance directive or end of life care planning.

  20. Random walkers with extreme value memory: modelling the peak-end rule

    Science.gov (United States)

    Harris, Rosemary J.

    2015-05-01

    Motivated by the psychological literature on the ‘peak-end rule’ for remembered experience, we perform an analysis within a random walk framework of a discrete choice model where agents’ future choices depend on the peak memory of their past experiences. In particular, we use this approach to investigate whether increased noise/disruption always leads to more switching between decisions. Here extreme value theory illuminates different classes of dynamics indicating that the long-time behaviour is dependent on the scale used for reflection; this could have implications, for example, in questionnaire design.

  1. Narrative autonomy: three literary models of healthcare in the end of life.

    Science.gov (United States)

    Casado da Rocha, Antonio

    2014-04-01

    This article proposes a concept of narrative autonomy to supplement existing accounts in healthcare ethics. This is done by means of a comparison between three end-of-life scenarios: Tolstoy's The Death of Ivan Ilyich and two related contemporary stories by Lorrie Moore and Bernhard Schlink, which explore some problems arising when extremely individualistic notions of patient autonomy are put into practice. It is argued that the best model for palliative care is a cooperative one in which patient autonomy is understood as essentially social, and that involves decisional, executive, informational, and narrative dimensions.

  2. One size does not fit all - understanding the front-end and back-ens of business model innovation

    DEFF Research Database (Denmark)

    Günzel, Franziska; Holm, Anna B.

    2013-01-01

    production and delivery have affected key components of these business models, namely value creation, proposition, delivery and capture in the period 2002–2011. Our findings suggest the need to distinguish between front-end and back-end business model innovation processes, and to recognize the importance......Business model innovation is becoming a central research topic in management. However, a lack of a common understanding of the nature of the business model leads to disregarding its multifaceted structure when analyzing the business model innovation process. This article proposes a more detailed...... understanding of the business model innovation process by drawing on existing knowledge from new product development literature and examining the front-end and the back-end of business model innovation of three leading Danish newspapers. We studied how changes introduced during the development of digital news...

  3. Probalistisk short-term risk modeling for back-end fuel cycle and waste management facilities

    International Nuclear Information System (INIS)

    Kjellbert, N.A.

    1980-03-01

    This study of probabilistic short-term risk modeling of back-end fuel cycle and waste management facilities represents the continuation of work started in 1977. The purpose of the report is to present a more detailed survey of models and analysis techniques that mey be applicable. The definition of the risk concept and the nature of the facilities and events which are to be analyzed are described. The most important criteria are that the model or method shall be quantitative, logically/scientifically based, and be able to handle systems of some complexity. Several formalized analysis methods are described, most of them emanating from reliability theory. No single model will fulfill all criteria simultaneously, to the degree desired. Nevertheless, fault tree analysis seems to be an efficient tool in many applications, although it must probably be used together with other models in most cases. Other methodologies described can also be useful, such as failure modes and effects analysis, renewal theory and Markov chains, reliability block diagrams, event trees and cause/consequence diagrams, the GO methodology, Monte Carlo simulation, and, often necessary, various consequence modeling techniques. (author)

  4. Mathematical Modeling of a Lit-End Cigarette: Puffing Cycle and Effects of Puff Counts

    Directory of Open Access Journals (Sweden)

    Saidi MS

    2014-12-01

    Full Text Available The burning cycles of a lit-end cigarette were numerically simulated using a 3-D model that includes both the cigarette and its surrounding ambient air and the effects of buoyancy forces. The solid and gas phases were treated separately in a thermally non-equilibrium environment. The tobacco pyrolysis and char oxidation were modeled using multi-precursor models. The changes in tobacco column porosity and its subsequent effects on permeability and gas diffusivity were included. The mass, momentum, energy, and species transport equations were solved in a discretized computational domain using a commercially available computational fluid dynamics (CFD code. The model was applied to puff a cigarette under different puffing intensities and the effects of puff volume, puff profile, and puff duration were studied. The results show that the model is capable of reproducing the major features of a burning cigarette during both smoldering and puffing. For the puffing and puff-by-puff cases, the solid and gas temperatures as well as those mainstream smoke constituents predicted by the model are in a good agreement with experimental results. A parametric study shows the significant effect of puff volume, puff profile, ventilation rate, and puff counts on solid and gas phase temperatures as well as gaseous species concentrations and mainstream smoke delivery. The buoyancy forces have shown to be very important in both smoldering and puffing.

  5. The role of environmental controls in determining sardine and anchovy population cycles in the California Current: Analysis of an end-to-end model

    Science.gov (United States)

    Fiechter, Jerome; Rose, Kenneth A.; Curchitser, Enrique N.; Hedstrom, Katherine S.

    2015-11-01

    Sardine and anchovy are two forage species of particular interest because of their low-frequency cycles in adult abundance in boundary current regions, combined with a commercially relevant contribution to the global marine food catch. While several hypotheses have been put forth to explain decadal shifts in sardine and anchovy populations, a mechanistic basis for how the physics, biogeochemistry, and biology combine to produce patterns of synchronous variability across widely separated systems has remained elusive. The present study uses a 50-year (1959-2008) simulation of a fully coupled end-to-end ecosystem model configured for sardine and anchovy in the California Current System to investigate how environmental processes control their population dynamics. The results illustrate that slightly different temperature and diet preferences can lead to significantly different responses to environmental variability. Simulated adult population fluctuations are associated with age-1 growth (via age-2 egg production) and prey availability for anchovy, while they depend primarily on age-0 survival and temperature for sardine. The analysis also hints at potential linkages to known modes of climate variability, whereby changes in adult abundance are related to ENSO for anchovy and to the PDO for sardine. The connection to the PDO and ENSO is consistent with modes of interannual and decadal variability that would alternatively favor anchovy during years of cooler temperatures and higher prey availability, and sardine during years of warmer temperatures and lower prey availability. While the end-to-end ecosystem model provides valuable insight on potential relationships between environmental conditions and sardine and anchovy population dynamics, understanding the complex interplay, and potential lags, between the full array of processes controlling their abundances in the California Current System remains an on-going challenge.

  6. The upper end of climate model temperature projections is inconsistent with past warming

    International Nuclear Information System (INIS)

    Stott, Peter; Good, Peter; Jones, Gareth; Gillett, Nathan; Hawkins, Ed

    2013-01-01

    Climate models predict a large range of possible future temperatures for a particular scenario of future emissions of greenhouse gases and other anthropogenic forcings of climate. Given that further warming in coming decades could threaten increasing risks of climatic disruption, it is important to determine whether model projections are consistent with temperature changes already observed. This can be achieved by quantifying the extent to which increases in well mixed greenhouse gases and changes in other anthropogenic and natural forcings have already altered temperature patterns around the globe. Here, for the first time, we combine multiple climate models into a single synthesized estimate of future warming rates consistent with past temperature changes. We show that the observed evolution of near-surface temperatures appears to indicate lower ranges (5–95%) for warming (0.35–0.82 K and 0.45–0.93 K by the 2020s (2020–9) relative to 1986–2005 under the RCP4.5 and 8.5 scenarios respectively) than the equivalent ranges projected by the CMIP5 climate models (0.48–1.00 K and 0.51–1.16 K respectively). Our results indicate that for each RCP the upper end of the range of CMIP5 climate model projections is inconsistent with past warming. (letter)

  7. End-of-life care in general practice: a cross-sectional, retrospective survey of ‘cancer’, ‘organ failure’ and ‘old-age/dementia’ patients.

    NARCIS (Netherlands)

    Evans, N.; Pasman, H.R.W.; Donker, G.A.; Deliens, L.; Block, L. van den; Onwuteaka-Philipsen, B.

    2014-01-01

    Background: End-of-life care is often provided in primary care settings. Aim: To describe and compare general-practitioner end-of-life care for Dutch patients who died from ‘cancer’, ‘organ failure’ and ‘old-age or dementia’. Design: A cross-sectional, retrospective survey was conducted within a

  8. Snow cover and End of Summer Snowline statistics from a simple stochastic model

    Science.gov (United States)

    Petrelli, A.; Crouzy, B.; Perona, P.

    2012-04-01

    One essential parameter characterizing snow cover statistics is the End Of Summer Snowline (EOSS), which is also a good indicator of actual climatic trends in mountain regions. EOSS is usually modelled by means of spatially distributed physically based models, and typically require heavy parameterization. In this paper we validate the simple stochastic model proposed by Perona et al. (2007), by showing that the snow cover statistics and the position of EOSS can in principle be explained by only four essential (meteorological) parameters. Perona et al. (2007) proposed a model accounting for stochastic snow accumulation in the cold period, and deterministic melting dynamics in the warm period, and studied the statistical distribution of the snowdepth on the long term. By reworking the ensemble average of the steady state evolution equation we single out a relationship between the snowdepth statistics (including the position of EOSS) and the involved parameters. The validation of the established relationship is done using 50 years of field data from 73 Swiss stations located above 2000 m a.s.l. First an estimation of the meteorological parameters is made. Snow height data are used as a precipitation proxy, using temperature data to estimate SWE during the precipitation event. Thresholds are used both to separate accumulation from actual precipitation and wind transport phenomena, and to better assess summer melting rate, considered to be constant over the melting period according to the simplified model. First results show that data for most of the weather stations actually scales with the proposed relationship. This indicates that, on the long term, the effect of spatial and temporal noise masks most of the process detail so that minimalist models suffice to obtain reliable statistics. Future works will test the validity of this approach at different spatial scales, e.g., regional, continental and planetary. Reference: P. Perona, A. Porporato, and L. Ridolfi, "A

  9. Modeling of end-pumped Yb:YAG thin-disk lasers with nonuniform temperature distribution.

    Science.gov (United States)

    Zhu, Guangzhi; Zhu, Xiao; Zhu, Changhong; Shang, Jianli; Wan, Hailin; Guo, Fei; Qi, Lijun

    2012-05-10

    A plane wave model with nonuniform temperature distribution in the thin-disk crystal is developed to describe the dynamic behavior of an end-pumped Yb:YAG thin-disk laser. A set of couple-rate equations and 2D stationary heat-conduction equations are derived. The stable temperature distribution in the disk crystal is calculated using a numerical iterative method. The analytic expression is capable of dealing with more practical laser systems than previous works on this subject as it allows for nonuniform temperature distribution in the disk crystal. Based on these results, we examined laser output intensity as a function of pump intensity, dopant concentration, resonator coupler reflectivity, crystal thickness and temperature of cooling liquid.

  10. 3D-modeling for determination of axial forces acting in elements of the end zone of power turbogenerators

    Directory of Open Access Journals (Sweden)

    Y.A.Haydenko

    2013-12-01

    Full Text Available A field mathematical model of the end zone of a powerful generator type TVV-1000-2U3 in the 3D-setting is developed. Modelling of the nominal mode of turbogenerator operation is done. The distribution of the electromagnetic field, eddy currents, and the Ampere force appearing in such elements of the end zone of turbogenerator as the pressure plate, push pins and electrically conductive screen.

  11. Modelling and performance of heat pipes with long evaporator sections

    NARCIS (Netherlands)

    Wits, Wessel W.; te Riele, Gert Jan

    2017-01-01

    This paper presents a planar cooling strategy for advanced electronic applications using heat pipe technology. The principle idea is to use an array of relatively long heat pipes, whereby heat is disposed to a long section of the pipes. The proposed design uses 1 m long heat pipes and top cooling

  12. Health related quality of life in patients with end stage kidney disease treated with haemodialysis in Malawi: a cross sectional study.

    Science.gov (United States)

    Masina, Thokozani; Chimera, Bernadette; Kamponda, Martin; Dreyer, Gavin

    2016-07-07

    Haemodialysis in Malawi consumes a disproportionate amount of the national health budget, costing approximately $20,000 per patient per year. Adjunctive therapeutic agents for end stage kidney disease and laboratory services to measure standard dialysis outcomes are not routinely available. Therefore, alternative outcome measures of the efficacy of haemodialysis in Malawi are required. We measured health related quality of life of adult patients in Malawi treated with haemodialysis for end stage kidney disease. We performed a cross-sectional study of patients receiving haemodialysis for end stage kidney disease at 4 dialysis centres in Malawi between 24/10/2012 and 30/11/012. Patients were included if they were >18 years of age and had been receiving haemodialysis for >3 months. We used the Kidney Disease Quality of Life Instrument Short Form to assess health related quality of life. We recruited 22 of 24 eligible patients (mean age 44.8 ± 16.0 years, 59.1 % male, median duration on haemodialysis 12 months (Inter-quartile range 6-24 months)). Overall health related quality of life was low (mean score 59.9 ± 8.8, maximum possible score 100) with the lowest scores recorded for physical health component summary score (50.4 ± 22.8) compared to mental health component summary (61.3 ± 23.0) and kidney disease component summary (67.9 ± 13.2). Low household income (<$4000 per year) was associated with lower mental health component scores (adjusted r(2) = 0.413, p = 0.033). Quality of life of haemodialysis patients in Malawi can be easily measured using a validated questionnaire and provides an alternative and important measure of the efficacy of haemodialysis therapy. Physical health scores were particularly low and this may affect income generating capacity. Increased efforts are required to improve the quality of life of haemodialysis patients in Malawi with a particular focus on the burden of physical symptoms.

  13. Modeling and Simulation of a Nuclear Fuel Element Test Section

    Science.gov (United States)

    Moran, Robert P.; Emrich, William

    2011-01-01

    "The Nuclear Thermal Rocket Element Environmental Simulator" test section closely simulates the internal operating conditions of a thermal nuclear rocket. The purpose of testing is to determine the ideal fuel rod characteristics for optimum thermal heat transfer to their hydrogen cooling/working fluid while still maintaining fuel rod structural integrity. Working fluid exhaust temperatures of up to 5,000 degrees Fahrenheit can be encountered. The exhaust gas is rendered inert and massively reduced in temperature for analysis using a combination of water cooling channels and cool N2 gas injectors in the H2-N2 mixer portion of the test section. An extensive thermal fluid analysis was performed in support of the engineering design of the H2-N2 mixer in order to determine the maximum "mass flow rate"-"operating temperature" curve of the fuel elements hydrogen exhaust gas based on the test facilities available cooling N2 mass flow rate as the limiting factor.

  14. A cosmological model with compact space sections and low mass density

    International Nuclear Information System (INIS)

    Fagundes, H.V.

    1982-01-01

    A general relativistic cosmological model is presented, which has closed space sections and mass density below a critical density similar to that of Friedmann's models. The model may predict double images of cosmic sources. (Author) [pt

  15. A comparative 2D modeling of debris-flow propagation and outcomes for end-users

    Science.gov (United States)

    Bettella, F.; Bertoldi, G.; Pozza, E.; McArdell, B. W.; D'Agostino, V.

    2012-04-01

    In Alpine regions gravity-driven natural hazards, in particular debris flows, endanger settlements and human life. Mitigation strategies based on hazard maps are necessary tools for land planning. These maps can be made more precise by using numerical models to forecasting the inundated areas after a careful setting of those 'key parameters' (K-P) which directly affect the flow motion and its interaction with the ground surface. Several physically based 2D models are available for practitioners and governmental agencies, but the selection criteria of model type and of the related K-P remain flexible and partly subjective. This remark has driven us to investigate how different models simulate different types of debris flows (from granular to muddy debris flows, going through intermediate types), in particular when the flow is influenced by the presence of deposition basins. Two commercial 2D physical models (RAMMS and FLO-2D) have been tested for five well-documented debris flows events from five Italian catchments were different geology and flow dynamics are observed: 1) a viscous debris flow occurred in 2009 in a catchment with a metamorphic geology (Gadria torrent, Bolzano Province); 2) the 2009 granular debris flow in an granitic geological setting (Rio Dosson, Trento Province); 3-4) two events occurred in the 'rio Val del Lago' and 'rio Molinara' (Trento Province) in 2010 where porphyritic lithology prevails (intermediate granular debris flow); 5) the Rotolon torrent (Vicenza Province) 2009 debris flow containing sedimentary rocks enclosed in an abundant clay-rich matrix (intermediate viscous case). Event volumes range from 5.000 to 50.000 cubic meters. The Gadria, Rotolon and Val del Lago events are also influenced by artificial retention basins. Case study simulations allowed delineation of some practical end-user suggestions and good practices in order to guide the model choice and the K-P setting, particularly related to different flow dynamics. The

  16. Novel model for end-neuroma formation in the amputated rabbit forelimb

    Directory of Open Access Journals (Sweden)

    Kuiken Todd A

    2010-03-01

    Full Text Available Abstract Background The forelimb amputee poses many reconstructive challenges in the clinical setting, and there is a paucity of established surgical models for study. To further elucidate the pathogenic process in amputation neuroma formation, we created a reproducible, well-tolerated rabbit forelimb amputation model. Methods Upon approval from the Institutional Animal Care and Use Committee, 5 New Zealand White rabbits underwent left forelimb amputation. During this initial surgery, the median, radial and ulnar nerves were transected 1.6-2.5 (mean 2.0 cm distal to the brachial plexus, transposed onto the anterior chest wall and preserved at length. Six weeks subsequent to the amputation, the distal 5 mm of each neuroma was excised, and the remaining stump underwent histomorphometric analysis. Results The nerve cross sectional areas increased by factors of 1.99, 3.17, and 2.59 in the median (p = 0.077, radial (p Conclusion Given that the surgical model appears well-tolerated by the rabbits and that patterns of morphologic change are consistent and reproducible, we are encouraged to further investigate the utility of this model in the pathogenesis of neuroma formation.

  17. Theme section: Multi-dimensional modelling, analysis and visualization

    DEFF Research Database (Denmark)

    Guilbert, Éric; Coltekin, Arzu; Antón Castro, Francesc/François

    2016-01-01

    describing complex multidimensional phenomena. An example of the relevance of multidimensional modelling is seen with the development of urban modelling where several dimensions have been added to the traditional 2D map representation (Sester et al.,2011). These include obviously the third spatial dimension...... in order to provide a meaningful representation and assist in data visualisation and mining, modelling and analysis; such as data structures allowing representation at different scalesor in different contexts of thematic information. Such issues are of importance with regard to the mission of theI SPRS...

  18. SU-E-T-360: End-To-End Dosimetric Testing of a Versa HD Linear Accelerator with the Agility Head Modeled in Pinnacle3

    Energy Technology Data Exchange (ETDEWEB)

    Saenz, D; Narayanasamy, G; Cruz, W; Papanikolaou, N; Stathakis, S [University of Texas Health Science Center at San Antonio, San Antonio, TX (United States)

    2015-06-15

    Purpose: The Versa HD incorporates a variety of upgrades, primarily including the Agility head. The distinct dosimetric properties of the head from its predecessors combined with flattening-filter-free (FFF) beams require a new investigation of modeling in planning systems and verification of modeling accuracy. Methods: A model was created in Pinnacle{sup 3} v9.8 with commissioned beam data. Leaf transmission was modeled as <0.5% with maximum leaf speed of 3 cm/s. Photon spectra were tuned for FFF beams, for which profiles were modeled with arbitrary profiles rather than with cones. For verification, a variety of plans with varied parameters were devised, and point dose measurements were compared to calculated values. A phantom of several plastic water and Styrofoam slabs was scanned and imported into Pinnacle{sup 3}. Beams of different field sizes, SSD, wedges, and gantry angles were created. All available photon energies (6 MV, 10 MV, 18 MV, 6 FFF, 10 FFF) as well four clinical electron energies (6, 9, 12, and 15 MeV) were investigated. The plans were verified at a calculation point (8 cm deep for photons, variable for electrons) by measurement with a PTW Semiflex ionization chamber. In addition, IMRT testing was performed with three standard plans (step and shoot IMRT, small and large field VMAT plans). The plans were delivered on the Delta4 IMRT QA phantom (ScandiDos, Uppsala, Sweden). Results: Homogeneous point dose measurement agreed within 2% for all photon and electron beams. Open field photon measurements along the central axis at 100 cm SSD passed within 1%. Gamma passing rates were >99.5% for all plans with a 3%/3mm tolerance criteria. The IMRT QA results for the first 23 patients yielded gamma passing rates of 97.4±2.3%. Conclusion: The end-to-end testing ensured confidence in the ability of Pinnacle{sup 3} to model photon and electron beams with the Agility head.

  19. Semiclassical model of cross section for fast neutrons

    International Nuclear Information System (INIS)

    Rosato, A.; D'Oliveira, A.A.

    1977-01-01

    A study for main aspects of fast neutron scattering is presented and, a semiclassical approximation applying to several pratic cases is described. The obtained results are compared with experimental data for deformed nuclei, and, with theoretical data based on optical model without treatment of deformations. (M.C.K.) [pt

  20. Study regarding seat’s rigidity during rear end collisions using a MADYMO occupant model

    Science.gov (United States)

    Ionut Radu, Alexandru; Cofaru, Corneliu; Tolea, Bogan; Popescu, Mihaela

    2017-10-01

    The aim of this paper is to study the effects of different front occupant backseat’s rigidities in the case of a rear end collision using a multibody virtual model of an occupant. Simulation will be conducted in PC Crash, the most common accident reconstruction software using a MADYMO multibody occupant to simulate kinematics and dynamic of the passenger. Different backseat torques will be used to see how this will influence the acceleration in the head and torso of the occupant. Also, a real crash test is made to analyze the kinematics of the occupant. We believe that the softer seat’s rigidity will reduce not only the head’s acceleration but also reduces the effect of „whiplash” upon the neck due to the fact that the backseat will rotate backwards increasing its displacement and absorb some of the energy generated by the collision. Although a softer seat could reduce the head’s acceleration, a broken seat will increase it due to the fact that the impact of the backseat with the vehicle’s rear seats will generate a second collision. So, in order to achieve a lower acceleration, a controlled torque is recommended and a controlled angular displacement of the backseat is to be used.

  1. Large animal model of functional tricuspid regurgitation in pacing induced end-stage heart failure.

    Science.gov (United States)

    Malinowski, Marcin; Proudfoot, Alistair G; Langholz, David; Eberhart, Lenora; Brown, Michael; Schubert, Hans; Wodarek, Jeremy; Timek, Tomasz A

    2017-06-01

    Functional tricuspid regurgitation (FTR) is common in patients with advanced heart failure and frequently complicates left ventricular assist device implantation yet remains poorly understood. We set out to establish large animal model of FTR that could serve as a research platform to investigate the pathogenesis of FTR associated with end-stage heart failure. : Through right thoracotomy, ten adult sheep underwent implantation of pacemaker with epicardial LV lead, five sonomicrometry crystals on the right ventricle, and left and right ventricular telemetry pressure sensors during a beating heart off-pump procedure. After 5 ± 1 days of recovery, baseline haemodynamic, echocardiographic and sonomicrometry data were collected. Animals were paced thereafter at a rate of 220-240 beats/min until the development of heart failure and concomitant tricuspid regurgitation. : Three animals died during early recovery period and one during the pacing phase. Six surviving animals were paced for a mean of 14 ± 5 days. Cardiac function was significantly depressed compared to baseline, with LV ejection fraction falling from 69 ± 2% to 22 ± 4% ( P  heart failure patients presenting for mechanical support. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  2. Quantifying EV battery end-of-life through analysis of travel needs with vehicle powertrain models

    Science.gov (United States)

    Saxena, Samveg; Le Floch, Caroline; MacDonald, Jason; Moura, Scott

    2015-05-01

    Electric vehicles enable clean and efficient transportation, however concerns about range anxiety and battery degradation hinder EV adoption. The common definition for battery end-of-life is when 70-80% of original energy capacity remains, however little analysis is available to support this retirement threshold. By applying detailed physics-based models of EVs with data on how drivers use their cars, we show that EV batteries continue to meet daily travel needs of drivers well beyond capacity fade of 80% remaining energy storage capacity. Further, we show that EV batteries with substantial energy capacity fade continue to provide sufficient buffer charge for unexpected trips with long distances. We show that enabling charging in more locations, even if only with 120 V wall outlets, prolongs useful life of EV batteries. Battery power fade is also examined and we show EVs meet performance requirements even down to 30% remaining power capacity. Our findings show that defining battery retirement at 70-80% remaining capacity is inaccurate. Battery retirement should instead be governed by when batteries no longer satisfy daily travel needs of a driver. Using this alternative retirement metric, we present results on the fraction of EV batteries that may be retired with different levels of energy capacity fade.

  3. Neurospora and the dead-end hypothesis: genomic consequences of selfing in the model genus.

    Science.gov (United States)

    Gioti, Anastasia; Stajich, Jason E; Johannesson, Hanna

    2013-12-01

    It is becoming increasingly evident that adoption of different reproductive strategies, such as sexual selfing and asexuality, greatly impacts genome evolution. In this study, we test theoretical predictions on genomic maladaptation of selfing lineages using empirical data from the model fungus Neurospora. We sequenced the genomes of four species representing distinct transitions to selfing within the history of the genus, as well as the transcriptome of one of these, and compared with available data from three outcrossing species. Our results provide evidence for a relaxation of purifying selection in protein-coding genes and for a reduced efficiency of transposable element silencing by Repeat Induced Point mutation. A reduction in adaptive evolution was also identified in the form of reduced codon usage bias in highly expressed genes of selfing Neurospora, but this result may be confounded by mutational bias. Potentially counteracting these negative effects, the nucleotide substitution rate and the spread of transposons is reduced in selfing species. We suggest that differences in substitution rate relate to the absence, in selfing Neurospora, of the asexual pathway producing conidia. Our results support the dead-end theory and show that Neurospora genomes bear signatures of both sexual and asexual reproductive mode. © 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.

  4. Assessing End-Of-Supply Risk of Spare Parts Using the Proportional Hazard Model

    NARCIS (Netherlands)

    X. Li (Xishu); R. Dekker (Rommert); C. Heij (Christiaan); M. Hekimoğlu (Mustafa)

    2016-01-01

    textabstractOperators of long field-life systems like airplanes are faced with hazards in the supply of spare parts. If the original manufacturers or suppliers of parts end their supply, this may have large impacts on operating costs of firms needing these parts. Existing end-of-supply evaluation

  5. The validity of the means-end chain model of consumer behaviour

    DEFF Research Database (Denmark)

    Scholderer, Joachim; Grunert, Klaus G.

    2004-01-01

    (N = 90) was designed to test the hierarchicity and self-relevance postulates. Hierarchicity was tested by examining whether response facilitation effects were higher when primes and targets were directly associated nodes in a means-end chain (attributes and consequences, or consequences and values......) than when primes and targets were indirectly associated through a mediator (attributes and values, mediated by consequences). Self-relevance was tested by examining whether response facilitation effects were stronger when primes and targets were taken from a person's own means-end chain (as measured......Despite its popularity in consumer research, means-end chain theory suffers from problems of unconfirmed validity: the nomological status of its central construct, the means-end chain, is still unknown. The aim of the research reported here was threefold: (a) to reformulate means-end chain theory...

  6. A multinomial logit model-Bayesian network hybrid approach for driver injury severity analyses in rear-end crashes.

    Science.gov (United States)

    Chen, Cong; Zhang, Guohui; Tarefder, Rafiqul; Ma, Jianming; Wei, Heng; Guan, Hongzhi

    2015-07-01

    Rear-end crash is one of the most common types of traffic crashes in the U.S. A good understanding of its characteristics and contributing factors is of practical importance. Previously, both multinomial Logit models and Bayesian network methods have been used in crash modeling and analysis, respectively, although each of them has its own application restrictions and limitations. In this study, a hybrid approach is developed to combine multinomial logit models and Bayesian network methods for comprehensively analyzing driver injury severities in rear-end crashes based on state-wide crash data collected in New Mexico from 2010 to 2011. A multinomial logit model is developed to investigate and identify significant contributing factors for rear-end crash driver injury severities classified into three categories: no injury, injury, and fatality. Then, the identified significant factors are utilized to establish a Bayesian network to explicitly formulate statistical associations between injury severity outcomes and explanatory attributes, including driver behavior, demographic features, vehicle factors, geometric and environmental characteristics, etc. The test results demonstrate that the proposed hybrid approach performs reasonably well. The Bayesian network reference analyses indicate that the factors including truck-involvement, inferior lighting conditions, windy weather conditions, the number of vehicles involved, etc. could significantly increase driver injury severities in rear-end crashes. The developed methodology and estimation results provide insights for developing effective countermeasures to reduce rear-end crash injury severities and improve traffic system safety performance. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Design and Implementation of Radar Cross-Section Models on a Virtex-6 FPGA

    OpenAIRE

    Prashanth, B. U. V.

    2014-01-01

    The simulation of radar cross-section (RCS) models in FPGA is illustrated. The models adopted are the Swerling ones. Radar cross-section (RCS) which is also termed as echo area gives the amount of scattered power from a target towards the radar. This paper elucidates the simulation of RCS to represent the specified targets under different conditions, namely, aspect angle and frequency. This model is used for the performance evaluation of radar. RCS models have been developed for various targ...

  8. Studying psychosocial adaptation to end-stage renal disease: the proximal-distal model of health-related outcomes as a base model.

    Science.gov (United States)

    Chan, Ramony; Brooks, Robert; Erlich, Jonathan; Gallagher, Martin; Snelling, Paul; Chow, Josephine; Suranyi, Michael

    2011-05-01

    Studying psychosocial adaptation in end-stage renal disease (ESRD) is increasingly important, as it may explain the variability in health outcomes unaccounted for by clinical factors. The Brenner et al. proximal-distal model of health-related outcomes provides a theoretical foundation for understanding psychosocial adaptation and integrating health outcomes, clinical, and psychosocial factors (Brenner MH, Curbow B, Legro MW. The proximal-distal continuum of multiple health outcome measures: the case of cataract surgery. Med Care. 1995;33(4 Suppl):AS236-44). This study aims to empirically validate the proximal-distal model in the dialysis population and examine the impact of psychosocial factors on the model. A cross-sectional observational study was conducted with a sample of long-term dialysis patients (n=201). Eleven factors: quality of life (QoL), depression, positive affect, comorbidity, symptoms, physical functioning, disease accommodation, loss, self-efficacy, illness acceptance, and social support were measured by standardized psychometric scales. A three-month average of hemoglobin was used. Latent composite structural equation modeling was used to examine the models. The proximal-distal model with slight modification was supported by fit statistics [χ(2)=16.04, df=13, P=.25, root mean square error of approximation (RMSEA)=0.024], indicating that the impact of clinical factors on QoL is mediated through a range of functional and psychological factors, except for hemoglobin which impacts directly on QoL. The model with additional psychosocial factors was also supported by fit statistics (χ(2)=43.59, df=41, P=.36, RMSEA=0.018). These additional factors mainly impact on symptom status, psychological states, and QoL components of the model. The present study supported the proximal-distal model in the dialysis population and demonstrated the considerable impact of psychosocial factors on the model. The proximal-distal model plus psychosocial factors as a

  9. Multiple adjustable vascular clamp prototype: feasibility study on an experimental model of end-to-side microsurgical vascular anastomosis.

    Science.gov (United States)

    Pereira, A; Ichihara, S; Collon, S; Bodin, F; Gay, A; Facca, S; Liverneaux, P

    2014-12-01

    The aim of this study was to establish the feasibility of microsurgical end-to-side vascular anastomosis with a multiclamp adjustable vascular clamp prototype in an inert experimental model. Our method consisted of performing an end-to-side microsurgical anastomosis with 10/0 suture on a 2-mm diameter segment. In group 1, the end-to-side segment was held in place by a double clamp and a single end clamp. In group 2, the segment was held in place with a single multiclamp adjustable clamp. The average time for performing the anastomosis was shorter in group 2. The average number of sutures was the same in both groups. No leak was found and permeability was always positive in both groups. Our results show that performing end-to-side anastomosis with a multiclamp adjustable vascular clamp is feasible in an inert experimental model. Feasibility in a live animal model has to be demonstrated before clinical use. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  10. Simplified model for end-stage liver disease score predicts mortality for tricuspid valve surgery†

    Science.gov (United States)

    Tsuda, Kazumasa; Koide, Masaaki; Kunii, Yoshifumi; Watanabe, Kazumasa; Miyairi, Satoshi; Ohashi, Yuko; Harada, Takashi

    2013-01-01

    OBJECTIVES The model for end-stage liver disease score (MELD = 3.8*LN[total bilirubin] + 9.6*LN[creatinine] + 11.2*[PT-INR] + 6.4) predicts mortality for tricuspid valve surgery. However, the MELD is problematic in patients undergoing warfarin therapy, as warfarin affects the international normalized ratio (INR). This study aimed to determine whether a simplified MELD score that does not require the INR for calculation could predict mortality for patients undergoing tricuspid valve surgery. Simplified MELD METHODS A total of 172 patients (male: 66, female: 106; mean age, 63.8 ± 10.3 years) who underwent tricuspid replacement (n = 18) or repair (n = 154) from January 1991 to July 2011 at a single centre were included. Of them, 168 patients in whom the simplified MELD score could be calculated were retrospectively analysed. The relationship between in-hospital mortality and perioperative variables was assessed by univariate and multivariate analysis. RESULTS The rate of in-hospital mortality was 6.4%. The mean admission simplified MELD score for the patients who died was significantly higher than for those surviving beyond discharge (11.3 ± 4.1 vs 5.8 ± 4.0; P = 0.001). By multivariate analysis, independent risk factors for in-hospital mortality included higher simplified MELD score (P = 0.001) and tricuspid valve replacement (P = 0.023). In-hospital mortality and morbidity increased along with increasing simplified MELD score. Scores 14 were associated with mortalities of 0, 2.0, 8.3 and 66.7%, respectively. The incidence of serious complications (multiple organ failure, P = 0.005; prolonged ventilation, P = 0.01; need for haemodialysis; P = 0.002) was also significantly higher in patients with simplified MELD score ≥7. CONCLUSIONS The simplified MELD score predicts mortality in patients undergoing tricuspid valve surgery. This model requires only total bilirubin and creatinine and is therefore applicable in patients undergoing warfarin therapy. PMID:23403770

  11. Positive end-expiratory pressure improves survival in a rodent model of cardiopulmonary resuscitation using high-dose epinephrine.

    LENUS (Irish Health Repository)

    McCaul, Conán

    2009-10-01

    Multiple interventions have been tested in models of cardiopulmonary resuscitation (CPR) to optimize drug use, chest compressions, and ventilation. None has studied the effects of positive end-expiratory pressure (PEEP) on outcome. We hypothesized that because PEEP can reverse pulmonary atelectasis, lower pulmonary vascular resistance, and potentially improve cardiac output, its use during CPR would increase survival.

  12. Modelling and simulation of size selectivity in diamond mesh trawl cod-ends

    DEFF Research Database (Denmark)

    Herrmann, Bent

    of the fishing gear. The cod-end is the rearmost part of a trawl where catch accumulates and in which most of the size selection is known to take place. To date, the main method used to assess the selectivity of trawl cod-ends has been to run sea trials followed by statistical analysis of the obtained......Within many fisheries there is a widespread discard of fish. Furthermore, there are several fisheries where fish are caught before reaching the optimal size, leading to an adverse exploitation of the resources. One way to achieve a more optimal exploitation is to improve the size selectivity...

  13. End-Tidal CO2-Guided Chest Compression Delivery Improves Survival in a Neonatal Asphyxial Cardiac Arrest Model.

    Science.gov (United States)

    Hamrick, Justin T; Hamrick, Jennifer L; Bhalala, Utpal; Armstrong, Jillian S; Lee, Jeong-Hoo; Kulikowicz, Ewa; Lee, Jennifer K; Kudchadkar, Sapna R; Koehler, Raymond C; Hunt, Elizabeth A; Shaffner, Donald H

    2017-11-01

    To determine whether end-tidal CO2-guided chest compression delivery improves survival over standard cardiopulmonary resuscitation after prolonged asphyxial arrest. Preclinical randomized controlled study. University animal research laboratory. 1-2-week-old swine. After undergoing a 20-minute asphyxial arrest, animals received either standard or end-tidal CO2-guided cardiopulmonary resuscitation. In the standard group, chest compression delivery was optimized by video and verbal feedback to maintain the rate, depth, and release within published guidelines. In the end-tidal CO2-guided group, chest compression rate and depth were adjusted to obtain a maximal end-tidal CO2 level without other feedback. Cardiopulmonary resuscitation included 10 minutes of basic life support followed by advanced life support for 10 minutes or until return of spontaneous circulation. Mean end-tidal CO2 at 10 minutes of cardiopulmonary resuscitation was 34 ± 8 torr in the end-tidal CO2 group (n = 14) and 19 ± 9 torr in the standard group (n = 14; p = 0.0001). The return of spontaneous circulation rate was 7 of 14 (50%) in the end-tidal CO2 group and 2 of 14 (14%) in the standard group (p = 0.04). The chest compression rate averaged 143 ± 10/min in the end-tidal CO2 group and 102 ± 2/min in the standard group (p tidal CO2-guided chest compression delivery. The response of the relaxation arterial pressure and cerebral perfusion pressure to the initial epinephrine administration was greater in the end-tidal CO2 group than in the standard group (p = 0.01 and p = 0.03, respectively). The prevalence of resuscitation-related injuries was similar between groups. End-tidal CO2-guided chest compression delivery is an effective resuscitation method that improves early survival after prolonged asphyxial arrest in this neonatal piglet model. Optimizing end-tidal CO2 levels during cardiopulmonary resuscitation required that chest compression delivery rate exceed current guidelines

  14. Improved sectioned images and surface models of the whole dog body.

    Science.gov (United States)

    Park, Hyo Seok; Shin, Dong Sun; Cho, Dai Hai; Jung, Yong Wook; Park, Jin Seo

    2014-09-01

    The objective of this research was to produce high-quality sectioned images of a whole dog which can be used to create sectional anatomy atlases and three-dimensional (3D) models. A year old female beagle was sacrificed by potassium chloride injection and frozen. The frozen dog was then serially ground using a cryomacrotome. Sectioned surfaces were photographed using a digital camera to create 3555 sectioned images of whole dog body (intervals, 0.2 mm; pixel size, 0.1 mm; 48 bit color). In a sectioned image, structures of dimension greater than 0.1mm could be identified in detail. Photoshop was used to make segmented images of 16 structures. Sectioned and segmented images were stored in browsing software to allow easy access. Segmented images were reconstructed to make surface models of 16 structures using Mimics software and stored in portable document format (PDF) using Adobe 3D Reviewer software. In this research, state-of-art sectioned images and surface models were produced for the dog. The authors hope that the sectioned images produced will become a useful source of software for basic and clinical veterinary medicine, and therefore, are distributing the sectioned images and surface models through browsing software and PDF file available free of charge. Copyright © 2014 Elsevier GmbH. All rights reserved.

  15. New supervised learning theory applied to cerebellar modeling for suppression of variability of saccade end points.

    Science.gov (United States)

    Fujita, Masahiko

    2013-06-01

    A new supervised learning theory is proposed for a hierarchical neural network with a single hidden layer of threshold units, which can approximate any continuous transformation, and applied to a cerebellar function to suppress the end-point variability of saccades. In motor systems, feedback control can reduce noise effects if the noise is added in a pathway from a motor center to a peripheral effector; however, it cannot reduce noise effects if the noise is generated in the motor center itself: a new control scheme is necessary for such noise. The cerebellar cortex is well known as a supervised learning system, and a novel theory of cerebellar cortical function developed in this study can explain the capability of the cerebellum to feedforwardly reduce noise effects, such as end-point variability of saccades. This theory assumes that a Golgi-granule cell system can encode the strength of a mossy fiber input as the state of neuronal activity of parallel fibers. By combining these parallel fiber signals with appropriate connection weights to produce a Purkinje cell output, an arbitrary continuous input-output relationship can be obtained. By incorporating such flexible computation and learning ability in a process of saccadic gain adaptation, a new control scheme in which the cerebellar cortex feedforwardly suppresses the end-point variability when it detects a variation in saccadic commands can be devised. Computer simulation confirmed the efficiency of such learning and showed a reduction in the variability of saccadic end points, similar to results obtained from experimental data.

  16. Surface roughness prediction model in end milling of Al/SiCp MMC ...

    African Journals Online (AJOL)

    user

    Keywords: Surface roughness (Ra), Response surface method (RSM), End milling, Metal matrix composites. DOI: http://dx.doi.org/10.4314/ijest.v3i6.7. 1. Introduction. The recent advancements in the CNC machine tool technology and the wide availability in manufacturing of mechanical components made it possible to ...

  17. Observation-Based Dissipation and Input Terms for Spectral Wave Models, with End-User Testing

    Science.gov (United States)

    2014-09-30

    with End-User Testing Alexander V. Babanin Swinburne University of Technology, PO Box 218, Hawthorn, Victoria 3140 Australia phone: +61-3-9214-8033...Conf. on Ocean, Offshore and Arctic Eng. OMAE2012, July 1-6, 2012, Rio de Janeiro, Brasil , 5p Chalikov, D., and S. Rainchik, 2011: Coupled numerical

  18. Comparing the dependability and associations with functioning of the DSM-5 Section III trait model of personality pathology and the DSM-5 Section II personality disorder model.

    Science.gov (United States)

    Chmielewski, Michael; Ruggero, Camilo J; Kotov, Roman; Liu, Keke; Krueger, Robert F

    2017-07-01

    Two competing models of personality psychopathology are included in the fifth edition of the Diagnostic Statistical Manual of Mental Disorders ( DSM-5 ; American Psychiatric Association, 2013); the traditional personality disorder (PD) model included in Section II and an alternative trait-based model included in Section III. Numerous studies have examined the validity of the alternative trait model and its official assessment instrument, the Personality Inventory for DSM-5 (PID-5; Krueger, Derringer, Markon, Watson, & Skodol, 2012). However, few studies have directly compared the trait-based model to the traditional PD model empirically in the same dataset. Moreover, to our knowledge, only a single study (Suzuki, Griffin, & Samuel, 2015) has examined the dependability of the PID-5, which is an essential component of construct validity for traits (Chmielewski & Watson, 2009; McCrae, Kurtz, Yamagata, & Terracciano, 2011). The current study directly compared the dependability of the DSM-5 traits, as assessed by the PID-5, and the traditional PD model, as assessed by the Personality Diagnostic Questionnaire-4 (PDQ-4+), in a large undergraduate sample. In addition, it evaluated and compared their associations with functioning, another essential component of personality pathology. In general, our findings indicate that most DSM-5 traits demonstrate high levels of dependability that are superior to the traditional PD model; however, some of the constructs assessed by the PID-5 may be more state like. The models were roughly equivalent in terms of their associations with functioning. The current results provide additional support for the validity of PID-5 and the DSM-5 Section III personality pathology model. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  19. Predictive model for risk of cesarean section in pregnant women after induction of labor.

    Science.gov (United States)

    Hernández-Martínez, Antonio; Pascual-Pedreño, Ana I; Baño-Garnés, Ana B; Melero-Jiménez, María R; Tenías-Burillo, José M; Molina-Alarcón, Milagros

    2016-03-01

    To develop a predictive model for risk of cesarean section in pregnant women after induction of labor. A retrospective cohort study was conducted of 861 induced labors during 2009, 2010, and 2011 at Hospital "La Mancha-Centro" in Alcázar de San Juan, Spain. Multivariate analysis was used with binary logistic regression and areas under the ROC curves to determine predictive ability. Two predictive models were created: model A predicts the outcome at the time the woman is admitted to the hospital (before the decision to of the method of induction); and model B predicts the outcome at the time the woman is definitely admitted to the labor room. The predictive factors in the final model were: maternal height, body mass index, nulliparity, Bishop score, gestational age, macrosomia, gender of fetus, and the gynecologist's overall cesarean section rate. The predictive ability of model A was 0.77 [95% confidence interval (CI) 0.73-0.80] and model B was 0.79 (95% CI 0.76-0.83). The predictive ability for pregnant women with previous cesarean section with model A was 0.79 (95% CI 0.64-0.94) and with model B was 0.80 (95% CI 0.64-0.96). For a probability of estimated cesarean section ≥80%, the models A and B presented a positive likelihood ratio (+LR) for cesarean section of 22 and 20, respectively. Also, for a likelihood of estimated cesarean section ≤10%, the models A and B presented a +LR for vaginal delivery of 13 and 6, respectively. These predictive models have a good discriminative ability, both overall and for all subgroups studied. This tool can be useful in clinical practice, especially for pregnant women with previous cesarean section and diabetes.

  20. Special Section Guest Editorial: Nanostructured Thin Films IX: Design, Fabrication, Characterization, and Modeling

    Science.gov (United States)

    Lakhtakia, Akhlesh; Mackay, Tom G.; Suzuki, Motofumi

    2017-10-01

    This guest editorial introduces the special section on Nanostructured Thin Films IX: Design, Fabrication, Characterization, and Modeling, which appears in the October-December 2017 issue of the Journal of Nanophotonics.

  1. Total cross sections of hadron interactions at high energies in low constituents number model

    International Nuclear Information System (INIS)

    Abramovskij, V.A.; Radchenko, N.V.

    2009-01-01

    We consider QCD hadrons interaction model in which gluons density is low in initial state wave function in rapidity space and real hadrons are produced from color strings decay. In this model behavior of total cross sections of pp, pp bar, π ± p, K ± p, γp, and γγ interactions is well described. The value of proton-proton total cross section at LHC energy is predicted

  2. A wide-range model of two-group gross sections in the dynamics code HEXTRAN

    International Nuclear Information System (INIS)

    Kaloinen, E.; Peltonen, J.

    2002-01-01

    In dynamic analyses the thermal hydraulic conditions within the reactor core may have a large variation, which sets a special requirement on the modeling of cross sections. The standard model in the dynamics code HEXTRAN is the same as in the static design code HEXBU-3D/MODS. It is based on a linear and second order fitting of two-group cross sections on fuel and moderator temperature, moderator density and boron density. A new, wide-range model of cross sections developed in Fortum Nuclear Services for HEXBU-3D/MOD6 has been included as an option into HEXTRAN. In this model the nodal cross sections are constructed from seven state variables in a polynomial of more than 40 terms. Coefficients of the polynomial are created by a least squares fitting to the results of a large number of fuel assembly calculations. Depending on the choice of state variables for the spectrum calculations, the new cross section model is capable to cover local conditions from cold zero power to boiling at full power. The 5. dynamic benchmark problem of AER is analyzed with the new option and results are compared to calculations with the standard model of cross sections in HEXTRAN (Authors)

  3. Photoproduction within the two-component Dual Parton Model: amplitudes and cross sections

    International Nuclear Information System (INIS)

    Engel, R.; Siegen Univ.

    1995-01-01

    In the framework of the Dual Parton Model an approximation scheme to describe high energy photoproduction processes is presented. Based on the distinction between direct, resolved soft, and resolved hard interaction processes we construct effective impact parameter amplitudes. In order to treat low mass diffraction within the eikonal formalism in a consistent way a phenomenological ansatz is proposed. The free parameters of the model are determined by fits to high energy hadro- and photoproduction cross sections. We calculate the partial photoproduction cross sections and discuss predictions of the model at HERA energies. Using hadro- and photoproduction data together, the uncertainties of the model predictions are strongly reduced. (orig.)

  4. Modeling Soft Gluons and Fiducial Cross Sections: New Physics or Old QCD?

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    In this talk I will describe some of the consequences of the consistently discrepant WW cross section measured at ATLAS and CMS. I will describe models where stops can be as light as 200 GeV satisfying naturalness constraints. I will also discuss the current states of the art modeling of QCD effects in the measurement of the cross section using p_T resummation. I will show that there is a sizable effect caused by a jet veto in extrapolating to the total cross section, but ultimately not enough to explain the current discrepancy.

  5. Mercury anomalies as a proxy for large igneous province volicanism and effects on the carbon cycle in a U-Pb age-constrained section spanning the end-Triassic mass extinction, Levanto, Peru

    Science.gov (United States)

    Yager, J. A.; West, A. J.; Bergquist, B. A.; Thibodeau, A. M.; Corsetti, F. A.; Berelson, W.; Rosas, S.; Bottjer, D. J.

    2017-12-01

    Understanding the causes of the end-Triassic extinction and their potential relationship to Central Atlantic Magmatic Province (CAMP) volcanism necessitates careful correlation of carbon cycle records (largely from marine sections) and volcanism (largely from terrestrial successions) in a robust chronological framework. Here, we report stable carbon isotopes and mercury concentrations and isotopes from the Levanto section in Northern Peru as a putative proxy for CAMP (a large igneous province) in a marine section. Levanto represents deposition well below storm wave base and is lithologically homogenous before, during, and after the end-Triassic extinction interval, making it ideal for detailed chemostratigraphy. Furthermore, abundant intercalated ash beds allow us to correlate mercury concentrations in the marine record directly with CAMP basalt ages, providing a test of the correspondence of mercury anomalies with the eruption of CAMP volcanics. Age dating and C isotope analyses provide an opportunity to explore orbital tuning of the carbon isotope record and ground truth it with existing U-Pb ages from the section, a feature not available in any other marine sections examined to date. The abundance of U-Pb dated ashes in the Levanto section allows us to correlate orbital tuning with other basins, which lack absolute age control, providing a better understanding for the C cycle changes associated with the Triassic-Jurassic boundary.

  6. Mathematical modeling of the heat transfer during pyrolysis process used for end-of-life tires treatment

    Science.gov (United States)

    Zheleva, I.; Georgiev, I.; Filipova, M.; Menseidov, D.

    2017-10-01

    Mathematical modeling of the heat transfer during the pyrolysis process used for the treatment of the End-of-Lifetires (EOLT) is presented in this paper. The pyrolysis process is 3D and non-stationary and because of this it is very complicated for modeling and studying. To simplify the modeling here a hierarchy of 2D models for the temperature which describe the non-stationary heat transfer in such a pyrolysis station is created. An algorithm for solving the model equations, based on MATLAB software is developed. The results for the temperature for some characteristic periods of operation of pyrolysis station are presented and commented in the paper. The results from this modeling can be used in the real pyrolysis station for more precise displacement of measurement devices and for designing of automated management of the process.

  7. Model of a generator end-winding cage; Modelisation d`une cage de developpantes d`alternateur

    Energy Technology Data Exchange (ETDEWEB)

    Leger, A.C.; Fanton, J.P.; Davies, C.

    1994-09-01

    This document presents some studies concerning the vibratory characterization of particular structures called: generator end-winding cages. These structures are mainly made up of the endings of armature windings. The question of their good mechanical behaviour is of prime importance, since they are submitted to high electromagnetic efforts during the different electrical ratings encountered during operation. The designer (GEC-Alsthom) and the user (EDF) have both undertaken numerical calculations in order to characterize a given machine, in this case a 600 MW bipolar generator; it appeared interesting to compare such calculations. The models realized respectively by GEC-Alsthom and EDF make use of different techniques and hypotheses. GEC-Alsthom represents the sets of rods and spacers by plates, which properties are determined by a pre-processor. The model is simplified to take into account the existing symmetries. It takes profit of previous experience and aims at a fast utilisation. The EDF model tends to allow a further comprehensive calculation, form the electromagnetic efforts to the determination of local stresses. The whole set of the constituting elements of the structure is modelled by beams, which leads to an important size for the model (21 000 degrees of freedom). The validation performed on the two models has been focused on the comparison between respective results and also with experimental results. Each model provides values for the first eigenfrequencies and the associated modes shapes. (authors). 3 refs., 3 figs., 2 tabs.

  8. Application of a simple Ramsauer model for neutron total cross sections

    International Nuclear Information System (INIS)

    Bauer, R.W.; Anderson, J.D.; Grimes, S.M.; Knapp, D.A.; Madsen, V.A.

    1998-01-01

    A companion paper presented arguments that support the applicability of a simple Ramsauer model to describe neutron total cross sections. Such a model yields a simple equation for the energy dependence of the cross section of a given nucleus and also allows extrapolation to nuclei of other A values. Fits of the Ramsauer form to very precise total cross sections recently measured over an extended energy range are presented. Very good fits are obtained for neutron energies between 6 and 60 MeV, suggesting that this approach will be useful for estimating cross sections in cases where experimental data are unavailable. Extension of this model to 120 MeV was only moderately successful

  9. Modeling and optimization of membrane lifetime in dead-end ultra filtration

    NARCIS (Netherlands)

    Zondervan, Edwin; Roffel, Brian

    2008-01-01

    In this paper, a membrane lifetime model is developed and experimentally validated. The lifetime model is based on the Weibull probability density function. The lifetime model can be used to determine an unambiguous characteristic membrane lifetime. Experimental results showed that membrane lifetime

  10. End-of-life care in the United States: policy issues and model programs of integrated care

    Directory of Open Access Journals (Sweden)

    Joshua M. Wiener

    2003-05-01

    Full Text Available Background: End-of-life care financing and delivery in the United States is fragmented and uncoordinated, with little integration of acute and long-term care services. Objective: To assess policy issues involving end-of-life care, especially involving the hospice benefit, and to analyse model programs of integrated care for people who are dying. Methods: The study conducted structured interviews with stakeholders and experts in end-of-life care and with administrators of model programs in the United States, which were nominated by the experts. Results: The two major public insurance programs—Medicare and Medicaid—finance the vast majority of end-of-life care. Both programs offer a hospice benefit, which has several shortcomings, including requiring physicians to make a prognosis of a six month life expectancy and insisting that patients give up curative treatment—two steps which are difficult for doctors and patients to make—and payment levels that may be too low. In addition, quality of care initiatives for nursing homes and hospice sometimes conflict. Four innovative health systems have overcome these barriers to provide palliative services to beneficiaries in their last year of life. Three of these health systems are managed care plans which receive capitated payments. These providers integrate health, long-term and palliative care using an interdisciplinary team approach to management of services. The fourth provider is a hospice that provides palliative services to beneficiaries of all ages, including those who have not elected hospice care. Conclusions: End-of-life care is deficient in the United States. Public payers could use their market power to improve care through a number of strategies.

  11. A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud.

    Directory of Open Access Journals (Sweden)

    Ingrid Paine

    2016-04-01

    Full Text Available Mathematics is often used to model biological systems. In mammary gland development, mathematical modeling has been limited to acinar and branching morphogenesis and breast cancer, without reference to normal duct formation. We present a model of ductal elongation that exploits the geometrically-constrained shape of the terminal end bud (TEB, the growing tip of the duct, and incorporates morphometrics, region-specific proliferation and apoptosis rates. Iterative model refinement and behavior analysis, compared with biological data, indicated that the traditional metric of nipple to the ductal front distance, or percent fat pad filled to evaluate ductal elongation rate can be misleading, as it disregards branching events that can reduce its magnitude. Further, model driven investigations of the fates of specific TEB cell types confirmed migration of cap cells into the body cell layer, but showed their subsequent preferential elimination by apoptosis, thus minimizing their contribution to the luminal lineage and the mature duct.

  12. Neutrino-nucleon cross-section at ultra-high energies in models with ...

    Indian Academy of Sciences (India)

    sUKANTA PANDA. Physics Department, Indian Institute of Technology, Kanpur 208 016, India. Abstract. We examine whether the models with large extra dimensions can provide an explanation for the GZK violating ultra-high energy cosmic rays (UHECR). In these models the neutrino-nucleon cross-section rises rapidly ...

  13. Validation of models that predict Cesarean section after induction of labor

    NARCIS (Netherlands)

    Verhoeven, C. J. M.; Oudenaarden, A.; Hermus, M. A. A.; Porath, M. M.; Oei, S. G.; Mol, B. W. J.

    2009-01-01

    Objective Models for the prediction of Cesarean delivery after induction of labor can be used to improve clinical decision-making. The objective of this study was to validate two existing models, published by Peregrine et al. and Rane et al., for the prediction of Cesarean section after induction of

  14. Modeling the curing process of thick-section autoclave cured composites

    Science.gov (United States)

    Loos, A. C.; Dara, P. H.

    1985-01-01

    Temperature gradients are significant during cure of large area, thick-section composites. Such temperature gradients result in nonuniformly cured parts with high void contents, poor ply compaction, and variations in the fiber/resin distribution. A model was developed to determine the temperature distribution in thick-section autoclave cured composites. Using the model, long with temperature measurements obtained from the thick-section composites, the effects of various processing parameters on the thermal response of the composites were examined. A one-dimensional heat transfer model was constructed for the composite-tool assembly. The governing differential equations and associated boundary conditions describing one-dimensional unsteady heat-conduction in the composite, tool plate, and pressure plate are given. Solution of the thermal model was obtained using an implicit finite difference technique.

  15. 78 FR 8535 - Medicare Program: Comprehensive End-Stage Renal Disease Care Model Announcement

    Science.gov (United States)

    2013-02-06

    ... Model, CMS will enter shared financial risk arrangements through ``Participation Agreements'' with... establishing new incentives for dialysis facilities, nephrologists, and other healthcare providers and...

  16. Biomechanical performance of flexible intramedullary nails with end caps tested in distal segmental defects of pediatric femur models.

    Science.gov (United States)

    Volpon, José Batista; Perina, Maurício Martins; Okubo, Rodrigo; Maranho, Daniel Augusto Carvalho

    2012-01-01

    Unstable distal femoral fractures in children are challenging lesions with restricted surgical options for adequate stabilization. Elastic nails have become popular for treating femoral shaft fractures, yet they are still challenging for using in distal fractures. The aim of this study was to test whether end caps (CAP) inserted into the nail extremity improved the mechanical stabilization of a segmental defect at the distal femoral metaphyseal-diaphyseal junction created in an artificial pediatric bone model. Two 3.5-mm titanium elastic nails (TEN) were introduced intramedullary into pediatric femur models, and a 7.0-mm-thick segmental defect was created at the distal diaphyseal-metaphyseal junction. Nondestructive 4-point bending, axial-bending, and torsion tests were conducted. After this, the end caps were inserted into the external tips of the nails and then screwed into the bone cortex. The mechanical tests were repeated. Stiffness, displacement, and torque were analyzed using the Wilcoxon nonparametric test for paired samples. In the combined axial-bending tests, the TEN+CAP combination was 8.75% stiffer than nails alone (Ptorsion tests, the TEN+CAP was 14% stiffer than nails alone (Pbending test did not show differences between the methods (P=0.91, stiffness; P=0.51, displacement). Thus, the end caps contributed to an increase in the construct stability for torsion and axial-bending forces but not for 4-point bending forces. These findings indicate that end caps fitted to elastic nails may contribute to the stabilization of fractures that our model mimics (small distal fragment, bone comminution, and distal bone fragment loss). Type II [therapeutic study: lesser-quality randomized controlled trial (eg, <80% follow-up, no blinding, or improper randomization)].

  17. Modelling the behavior of the Jakobshavn glacier since the end of the Little Ice Age

    DEFF Research Database (Denmark)

    Muresan, Ioana Stefania; Khroulev, Constantine; Khan, Shfaqat Abbas

    2014-01-01

    Current model estimates of the Greenland Ice Sheet (GrIS) are almost entirely based on coarse grids (>10km) and constrained by climate models that span from 60s to present. To improve the projection of future sea level rise, a long-term data record that reveals the mass balance beyond decadal tim...

  18. Modeling and optimization of a sequence of chemical cleaning cycles in dead-end ultrafiltration

    NARCIS (Netherlands)

    Zondervan, Edwin; Betlem, Ben H.L.; Blankert, Bastiaan; Roffel, Brian

    2008-01-01

    In this paper a chemical cleaning sequence model is proposed that can be used to predict the fouling status of a membrane during multiple chemical cleaning cycles. The proposed model is used to minimize the overall operating costs – based on chemicals consumption, energy consumption and investment

  19. PIV-validated numerical modeling of pulsatile flows in distal coronary end-to-side anastomoses.

    Science.gov (United States)

    Xiong, F L; Chong, C K

    2007-01-01

    This study employed particle image velocimetry (PIV) to validate a numerical model in a complementary approach to quantify hemodynamic factors in distal coronary anastomoses and to gain more insights on their relationship with anastomotic geometry. Instantaneous flow fields and wall shear stresses (WSS) were obtained from PIV measurement in a modified life-size silastic anastomosis model adapted from a conventional geometry by incorporating a smooth graft-artery transition. The results were compared with those predicted by a concurrent numerical model. The numerical method was then used to calculate cycle-averaged WSS (WSS(cyc)) and spatial wall shear stress gradient (SWSSG), two critical hemodynamic factors in the pathogenesis of intimal thickening (IT), to compare the conventional and modified geometries. Excellent qualitative agreement and satisfactory quantitative agreement with averaged normalized error in WSS between 0.8% and 8.9% were achieved between the PIV experiment and numerical model. Compared to the conventional geometry, the modified geometry produces a more uniform WSS(cyc) distribution eliminating both high and low WSS(cyc) around the toe, critical in avoiding IT. Peak SWSSG on the artery floor of the modified model is less than one-half that in the conventional case, and high SWSSG at the toe is eliminated. The validated numerical model is useful for modeling unsteady coronary anastomotic flows and elucidating the significance of geometry regulated hemodynamics. The results suggest the clinical relevance of constructing smooth graft-artery transition in distal coronary anastomoses to improve their hemodynamic performance.

  20. Comparative study for different statistical models to optimize cutting parameters of CNC end milling machines

    International Nuclear Information System (INIS)

    El-Berry, A.; El-Berry, A.; Al-Bossly, A.

    2010-01-01

    In machining operation, the quality of surface finish is an important requirement for many work pieces. Thus, that is very important to optimize cutting parameters for controlling the required manufacturing quality. Surface roughness parameter (Ra) in mechanical parts depends on turning parameters during the turning process. In the development of predictive models, cutting parameters of feed, cutting speed, depth of cut, are considered as model variables. For this purpose, this study focuses on comparing various machining experiments which using CNC vertical machining center, work pieces was aluminum 6061. Multiple regression models are used to predict the surface roughness at different experiments.

  1. Long-Run Effects in Large Heterogeneous Panel Data Models with Cross-Sectionally Correlated Errors

    OpenAIRE

    Chudik, Alexander; Mohaddes, Kamiar; Pesaran, M Hashem; Raissi, Mehdi

    2016-01-01

    This paper develops a cross-sectionally augmented distributed lag (CS-DL) approach to the estimation of long-run effects in large dynamic heterogeneous panel data models with cross-sectionally dependent errors. The asymptotic distribution of the CS-DL estimator is derived under coefficient heterogeneity in the case where the time dimension (T) and the cross-section dimension (N) are both large. The CS-DL approach is compared with more standard panel data estimators that are based on autoregre...

  2. Long-run effects in large heterogenous panel data models with cross-sectionally correlated errors

    OpenAIRE

    Chudik, Alexander; Mohaddes, Kamiar; Pesaran, M. Hashem; Raissi, Mehdi

    2015-01-01

    This paper develops a cross-sectionally augmented distributed lag (CS-DL) approach to the estimation of long-run effects in large dynamic heterogeneous panel data models with cross-sectionally dependent errors. The asymptotic distribution of the CS-DL estimator is derived under coefficient heterogeneity in the case where the time dimension (T) and the cross-section dimension (N) are both large. The CS-DL approach is compared with more standard panel data estimators that are based on autoregre...

  3. Modelling of electricity savings in the Danish households sector: from the energy system to the end-user

    DEFF Research Database (Denmark)

    Baldini, Mattia; Trivella, Alessio

    2017-01-01

    In this paper, we examine the value of investing in energy-efficient household appliances from both an energy system and end-user perspectives. We consider a set of appliance categories constituting the majority of the electricity consumption in the private household sector, and focus on the stock...... of products which need to be replaced. First, we look at the energy system and investigate whether investing in improved energy efficiency can compete with the cost of electricity supply from existing or new power plants. To assess the analysis, Balmorel, a linear optimization model for the heat and power...... sectors, has been extended in order to endogenously determine the best possible investments in more efficient home appliances. Second, we propose a method to relate the optimal energy system solution to the end-user choices by incorporating consumer behaviour and electricity price addition due to taxes...

  4. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

    Science.gov (United States)

    Cagle, Laura A; Franzi, Lisa M; Linderholm, Angela L; Last, Jerold A; Adams, Jason Y; Harper, Richart W; Kenyon, Nicholas J

    2017-01-01

    Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury. To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation. 5-12 week-old female BALB/c mice (n = 85) were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg) or high tidal volume (15 ml/kg) with or without positive end-expiratory pressure and recruitment maneuvers. Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation. Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours) and lung injury worsens with longer-term ventilation (4 hrs). Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points. Dynamic compliance can be used guide the frequency

  5. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

    Directory of Open Access Journals (Sweden)

    Laura A Cagle

    Full Text Available Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury.To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation.5-12 week-old female BALB/c mice (n = 85 were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg or high tidal volume (15 ml/kg with or without positive end-expiratory pressure and recruitment maneuvers.Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation.Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours and lung injury worsens with longer-term ventilation (4 hrs. Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points. Dynamic compliance can be used guide

  6. Model of passage of vessels through the waterway section forming the schedule in the course of its implementation

    Directory of Open Access Journals (Sweden)

    S. N. Plotnikov

    2017-01-01

    Full Text Available The model of passage of vessels through a section of the waterway is considered, which independently determines the order of passage of vessels with limited capacity of sections of the track. Such a model will consist of a number of standard algorithmic networks. When composing the schedule in the model, the following preference rules were used: first-come-first-served (that is, if the ship occupied the workplace, this decision is not canceled; The rule of the shortest operation; For the swamps the priority of vessels going downstream (the direction of flow from the source to the drain. An algorithmic network that implements the search for an acceptable schedule must implement the following for conflicting operations: the operation that has started is not interrupted; If several operations simultaneously claim for one workplace (port, reach and their number is greater than its throughput, then the conflict resolution is carried out in accordance with predefined preference rules or based on the user's decision; If the operation is waiting for the release of the workplace, it does not occupy the resource; The resource is returned immediately after the operation is completed. The considered design of algorithmic networks allows to resolve the conflict, with a simultaneous resource request, to take the resource once, remember that it was received and return it after the end of the operation, then the resource receives a contra-controlling operation for execution. However, the use of this design introduces redundancy into the model, even if it is used only for conflicting operations. The model is presented in the language of algorithmic networks and is implemented in the system of modeling automation KOGNITRON.

  7. Unobserved Heterogeneity in the Binary Logit Model with Cross-Sectional Data and Short Panels

    DEFF Research Database (Denmark)

    Holm, Anders; Jæger, Mads Meier; Pedersen, Morten

    This paper proposes a new approach to dealing with unobserved heterogeneity in applied research using the binary logit model with cross-sectional data and short panels. Unobserved heterogeneity is particularly important in non-linear regression models such as the binary logit model because, unlike...... in linear regression models, estimates of the effects of observed independent variables are biased even when omitted independent variables are uncorrelated with the observed independent variables. We propose an extension of the binary logit model based on a finite mixture approach in which we conceptualize...

  8. Remote Sensing for Crop Water Management: From ET Modelling to Services for the End Users

    Directory of Open Access Journals (Sweden)

    Alfonso Calera

    2017-05-01

    Full Text Available The experiences gathered during the past 30 years support the operational use of irrigation scheduling based on frequent multi-spectral image data. Currently, the operational use of dense time series of multispectral imagery at high spatial resolution makes monitoring of crop biophysical parameters feasible, capturing crop water use across the growing season, with suitable temporal and spatial resolutions. These achievements, and the availability of accurate forecasting of meteorological data, allow for precise predictions of crop water requirements with unprecedented spatial resolution. This information is greatly appreciated by the end users, i.e., professional farmers or decision-makers, and can be provided in an easy-to-use manner and in near-real-time by using the improvements achieved in web-GIS methodologies (Geographic Information Systems based on web technologies. This paper reviews the most operational and explored methods based on optical remote sensing for the assessment of crop water requirements, identifying strengths and weaknesses and proposing alternatives to advance towards full operational application of this methodology. In addition, we provide a general overview of the tools, which facilitates co-creation and collaboration with stakeholders, paying special attention to these approaches based on web-GIS tools.

  9. Optimal urban water conservation strategies considering embedded energy: coupling end-use and utility water-energy models.

    Science.gov (United States)

    Escriva-Bou, A.; Lund, J. R.; Pulido-Velazquez, M.; Spang, E. S.; Loge, F. J.

    2014-12-01

    Although most freshwater resources are used in agriculture, a greater amount of energy is consumed per unit of water supply for urban areas. Therefore, efforts to reduce the carbon footprint of water in cities, including the energy embedded within household uses, can be an order of magnitude larger than for other water uses. This characteristic of urban water systems creates a promising opportunity to reduce global greenhouse gas emissions, particularly given rapidly growing urbanization worldwide. Based on a previous Water-Energy-CO2 emissions model for household water end uses, this research introduces a probabilistic two-stage optimization model considering technical and behavioral decision variables to obtain the most economical strategies to minimize household water and water-related energy bills given both water and energy price shocks. Results show that adoption rates to reduce energy intensive appliances increase significantly, resulting in an overall 20% growth in indoor water conservation if household dwellers include the energy cost of their water use. To analyze the consequences on a utility-scale, we develop an hourly water-energy model based on data from East Bay Municipal Utility District in California, including the residential consumption, obtaining that water end uses accounts for roughly 90% of total water-related energy, but the 10% that is managed by the utility is worth over 12 million annually. Once the entire end-use + utility model is completed, several demand-side management conservation strategies were simulated for the city of San Ramon. In this smaller water district, roughly 5% of total EBMUD water use, we found that the optimal household strategies can reduce total GHG emissions by 4% and utility's energy cost over 70,000/yr. Especially interesting from the utility perspective could be the "smoothing" of water use peaks by avoiding daytime irrigation that among other benefits might reduce utility energy costs by 0.5% according to our

  10. Shortcomings of the Winkler model in the Assessment of Sectioned Tunnels under Seismic Loading

    DEFF Research Database (Denmark)

    Andersen, Lars; Lyngs, J. H.

    2009-01-01

    A Winkler-type model is often applied in the design of tunnels subject to seismic loading. Since the subgrade stiffness is modelled by disjoint springs, distributed continuously along the tunnel, the model does not account for retroaction via the soil. This may not be a problem in the design...... of tunnels with a uniform cross section. However, for sectioned tunnels divided into a number of elements, erroneous results may be expected-especially regarding the relative deformations at the joints. In this paper, the results of a Winkler model are compared with a full three-dimensional continuum finite......-element solution, using a planned tunnel at Thessaloniki, Greece, as a case study. The aim of the analysis is to quantify the inaccuracy of the Winkler model in the prediction of damage at a gasket between two tunnel elements....

  11. Shortcomings of the Winkler Model in the Assessment of Sectioned Tunnels under Seismic Loading

    DEFF Research Database (Denmark)

    Andersen, Lars; Lyngs, Jakob Hausgaard

    A Winkler-type model is often applied in the design of tunnels subject to seismic loading. Since the subgrade stiffness is modelled by disjoint springs, distributed continuously along the tunnel, the model does not account for retroaction via the soil. This may not be a problem in the design...... of tunnels with a uniform cross section. However, for sectioned tunnels divided into a number of elements, erroneous results may be expected-especially regarding the relative deformations at the joints. In this paper, the results of aWinkler model are compared with a full three-dimensional continuum finite......-element solution, using a planned tunnel at Thessaloniki, Greece, as a case study. The aim of the analysis is to quantify the inaccuracy of the Winkler model in the prediction of damage at a gasket between two tunnel elements....

  12. Equations of the End: Teaching Mathematical Modeling Using the Zombie Apocalypse †

    Science.gov (United States)

    Lofgren, Eric T.; Collins, Kristy M.; Smith, Tara C.; Cartwright, Reed A.

    2016-01-01

    Mathematical models of infectious diseases are a valuable tool in understanding the mechanisms and patterns of disease transmission. It is, however, a difficult subject to teach, requiring both mathematical expertise and extensive subject-matter knowledge of a variety of disease systems. In this article, we explore several uses of zombie epidemics to make mathematical modeling and infectious disease epidemiology more accessible to public health professionals, students, and the general public. We further introduce a web-based simulation, White Zed (http://cartwrig.ht/apps/whitezed/), that can be deployed in classrooms to allow students to explore models before implementing them. In our experience, zombie epidemics are familiar, approachable, flexible, and an ideal way to introduce basic concepts of infectious disease epidemiology. PMID:27047611

  13. Design and Implementation of Radar Cross-Section Models on a Virtex-6 FPGA

    Directory of Open Access Journals (Sweden)

    B. U. V. Prashanth

    2014-01-01

    Full Text Available The simulation of radar cross-section (RCS models in FPGA is illustrated. The models adopted are the Swerling ones. Radar cross-section (RCS which is also termed as echo area gives the amount of scattered power from a target towards the radar. This paper elucidates the simulation of RCS to represent the specified targets under different conditions, namely, aspect angle and frequency. This model is used for the performance evaluation of radar. RCS models have been developed for various targets like simple objects to complex objects like aircrafts, missiles, tanks, and so forth. First, the model was developed in MATLAB real time simulation environment and after successful verification, the same was implemented in FPGA. Xilinx ISE software was used for VHDL coding. This simulation model was used for the testing of a radar system. The results were compared with MATLAB simulations and FPGA based timing diagrams and RTL synthesis. The paper illustrates the simulation of various target radar cross-section (RCS models. These models are simulated in MATLAB and in FPGA, with the aim of implementing them efficiently on a radar system. This method can be generalized to apply to objects of arbitrary geometry for the two configurations of transmitter and receiver in the same as well as different locations.

  14. MARS-LMR modeling for the post-test analysis of Phenix End-of-Life natural circulation

    International Nuclear Information System (INIS)

    Jeong, Hae Yong; Ha, Kwi Seok; Chang, Won Pyo; Lee, Kwi Lim

    2011-01-01

    For a successful design and analysis of Sodium cooled Fast Reactor (SFR), it is required to have a reliable and well-proven system analysis code. To achieve this purpose, KAERI is enhancing the modeling capability of MARS code by adding the SFR-specific models such as pressure drop model, heat transfer model and reactivity feedback model. This version of MARS-LMR will be used as a basic tool in the design and analysis of future SFR systems in Korea. Before wide application of MARS-LMR code, it is required to verify and validate the code models through analyses for appropriate experimental data or analytical results. The end-of-life test of Phenix reactor performed by the CEA provided a unique opportunity to have reliable test data which is very valuable in the validation and verification of a SFR system analysis code. The KAERI joined this international program of the analysis of Phenix end-of-life natural circulation test coordinated by the IAEA from 2008. The main test of natural circulation was completed in 2009. Before the test the KAERI performed the pre-test analysis based on the design condition provided by the CEA. Then, the blind post-test analysis was also performed based on the test conditions measured during the test before the CEA provide the final test results. Finally, the final post-test analysis was performed recently to predict the test results as accurate as possible. This paper introduces the modeling approach of the MARS-LMR used in the final post-test analysis and summarizes the major results of the analysis

  15. A Non-Linear Finite Element Model for the LHC Main Dipole Coil Cross-Section

    CERN Document Server

    Pojer, M; Scandale, Walter

    2006-01-01

    The production of the dipole magnets for the Large Hadron Collider is at its final stage. Nevertheless, some mechanical instabilities are still observed for which no clear explanation has been found yet. A FE modelization of the dipole cold mass cross-section had already been developed at CERN, mainly for magnetic analysis, taking into account conductor blocks and a frictionless behavior. This paper describes a new ANSYS® model of the dipole coil cross-section, featuring individual turns inside conductor blocks, and implementing friction and the mechanical non-linear behavior of insulated cables. Preliminary results, comparison with measurements performed in industry and ongoing developments are discussed.

  16. Charged-current inclusive neutrino cross sections in the SuperScaling model

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, M. V., E-mail: martin.inrne@gmail.com [Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia 1784 (Bulgaria); Grupo de Física Nuclear, Departamento de Física Atómica, Molecular y Nuclear, Facultad de Ciencias Físicas, Universidad Complutense de Madrid, Madrid E-28040 (Spain); Megias, G. D.; Caballero, J. A. [Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla, 41080 Sevilla (Spain); González-Jiménez, R. [Department of Physics and Astronomy, Ghent University, Proeftuinstraat 86, B-9000 Gent (Belgium); Moreno, O.; Donnelly, T. W. [Center for Theoretical Physics, Laboratory for Nuclear Science and Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Barbaro, M. B. [Dipartimento di Fisica, Università di Torino and INFN, Sezione di Torino, Via P. Giuria 1, 10125 Torino (Italy); Antonov, A. N. [Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia 1784 (Bulgaria); Moya de Guerra, E.; Udías, J. M. [Grupo de Física Nuclear, Departamento de Física Atómica, Molecular y Nuclear, Facultad de Ciencias Físicas, Universidad Complutense de Madrid, Madrid E-28040 (Spain)

    2016-03-25

    SuperScaling model (SuSA) predictions to neutrino-induced charged-current π{sup +} production in the Δ-resonance region are explored under MiniBooNE experimental conditions. The SuSA charged-current π{sup +} results are in good agreement with data on neutrino flux-averaged double-differential cross sections. The SuSA model for quasielastic scattering and its extension to the pion production region are used for predictions of charged-current inclusive neutrino-nucleus cross sections. Results are also compared with the T2K experimental data for inclusive scattering.

  17. End-to-end verifiability

    OpenAIRE

    Benaloh, Josh; Rivest, Ronald; Ryan, Peter Y. A.; Stark, Philip; Teague, Vanessa; Vora, Poorvi

    2015-01-01

    This pamphlet describes end-to-end election verifiability (E2E-V) for a nontechnical audience: election officials, public policymakers, and anyone else interested in secure, transparent, evidence - based electronic elections. This work is part of the Overseas Vote Foundation’s End-to-End Verifiable Internet Voting: Specification and Feasibility Assessment Study (E2E VIV Project), funded by the Democracy Fund.

  18. Empathy among undergraduate medical students: A multi-centre cross-sectional comparison of students beginning and approaching the end of their course.

    Science.gov (United States)

    Quince, Thelma A; Kinnersley, Paul; Hales, Jonathan; da Silva, Ana; Moriarty, Helen; Thiemann, Pia; Hyde, Sarah; Brimicombe, James; Wood, Diana; Barclay, Matthew; Benson, John

    2016-03-15

    Although a core element in patient care the trajectory of empathy during undergraduate medical education remains unclear. Empathy is generally regarded as comprising an affective capacity: the ability to be sensitive to and concerned for, another and a cognitive capacity: the ability to understand and appreciate the other person's perspective. The authors investigated whether final year undergraduate students recorded lower levels of empathy than their first year counterparts, and whether male and female students differed in this respect. Between September 2013 and June 2014 an online questionnaire survey was administered to 15 UK, and 2 international medical schools. Participating schools provided both 5-6 year standard courses and 4 year accelerated graduate entry courses. The survey incorporated the Jefferson Scale of Empathy-Student Version (JSE-S) and Davis's Interpersonal Reactivity Index (IRI), both widely used to measure medical student empathy. Participation was voluntary. Chi squared tests were used to test for differences in biographical characteristics of student groups. Multiple linear regression analyses, in which predictor variables were year of course (first/final); sex; type of course and broad socio-economic group were used to compare empathy scores. Five medical schools (4 in the UK, 1 in New Zealand) achieved average response rates of 55 % (n = 652) among students starting their course and 48 % (n = 487) among final year students. These schools formed the High Response Rate Group. The remaining 12 medical schools recorded lower response rates of 24.0 % and 15.2 % among first and final year students respectively. These schools formed the Lower Response Rate Group. For both male and female students in both groups of schools no significant differences in any empathy scores were found between students starting and approaching the end of their course. Gender was found to significantly predict empathy scores, with females scoring higher

  19. Application of a residential end-use model for estimating cold and ...

    African Journals Online (AJOL)

    The model is first applied to confirm a few commonly observed water demand patterns: Seasonal variation in demand, the positive correlation between average annual daily water demand and stand size, and the increase in water demand, hot water demand and wastewater flow with an increase in household size.

  20. Higher Education End-of-Course Evaluations: Assessing the Psychometric Properties Utilizing Exploratory Factor Analysis and Rasch Modeling Approaches

    Directory of Open Access Journals (Sweden)

    Kelly D. Bradley

    2016-07-01

    Full Text Available This paper offers a critical assessment of the psychometric properties of a standard higher education end-of-course evaluation. Using both exploratory factor analysis (EFA and Rasch modeling, the authors investigate the (a an overall assessment of dimensionality using EFA, (b a secondary assessment of dimensionality using a principal components analysis (PCA of the residuals when the items are fit to the Rasch model, and (c an assessment of item-level properties using item-level statistics provided when the items are fit to the Rasch model. The results support the usage of the scale as a supplement to high-stakes decision making such as tenure. However, the lack of precise targeting of item difficulty to person ability combined with the low person separation index renders rank-ordering professors according to minuscule differences in overall subscale scores a highly questionable practice.

  1. Nonlinear Modeling and Dynamic Simulation Using Bifurcation and Stability Analyses of Regenerative Chatter of Ball-End Milling Process

    Directory of Open Access Journals (Sweden)

    Jeehyun Jung

    2016-01-01

    Full Text Available A dynamic model for a ball-end milling process that includes the consideration of cutting force nonlinearities and regenerative chatter effects is presented. The nonlinear cutting force is approximated using a Fourier series and then expanded into a Taylor series up to the third order. A series of nonlinear analyses was performed to investigate the nonlinear dynamic behavior of a ball-end milling system, and the differences between the nonlinear analysis approach and its linear counterpart were examined. A bifurcation analysis of points near the critical equilibrium points was performed using the method of multiple scales (MMS and the method of harmonic balance (MHB to analyse the local chatter behaviors of the system. The bifurcation analysis was conducted at two subcritical Hopf bifurcation points. It was also found that a ball-end milling system with nonlinear cutting forces near its critical equilibrium points is conditionally stable. The analysis and simulation results were compared with experimental data reported in the literature, and the physical significance of the results is discussed.

  2. Development of an end-of-life vehicle recovery model using system dynamics and future research needs

    Science.gov (United States)

    Mohamad-Ali, N.; Ghazilla, R. A. R.; Abdul-Rashid, S. H.; Sakundarini, N.; Ahmad-Yazid, A.; Stephenie, L.

    2017-06-01

    The implementation of end-of-life vehicle (ELV) recovery policy in Malaysia has led vehicle manufacturers to look at different ways to improve design and development of vehicles. Nowadays, it is crucial to incorporate end-of-life (EOL) design strategies into the vehicle design in order to enhance the effectiveness of the ELV recovery network. Although recent studies have shown that product design has a significant effect on the product recovery rate, there is a lack of studies on how EOL design strategies affects the effectiveness of ELV recovery, particularly when there are dynamic changes in the behaviour of the product recovery network. Thus, in this study, we developed a preliminary model based on the system dynamics approach in order to predict the effectiveness of ELV recovery in response to dynamic changes of various factors (including EOL design strategies) in the business environment. We developed this model based on preliminary data that we had gathered from unstructured interviews with the key stakeholders of ELV management in Malaysia. We believe that our model will greatly benefit product designers in incorporating the appropriate EOL design strategies in order to boost ELV recovery effectiveness in Malaysia.

  3. Silicon photomultipliers: On ground characterizations and modelling for use in front-end electronics aimed to space-borne experiments

    Energy Technology Data Exchange (ETDEWEB)

    Badoni, Davide [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy)]. E-mail: davide.badoni@roma2.infn.it; Altamura, Francesco [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Basili, Alessandro [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Bencardino, Raffaele [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Bidoli, Vittorio [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Casolino, Marco [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); De Carli, Anna [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Froysland, Tom [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Marchetti, Marcello [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Messi, Roberto [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Minori, Mauro [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Picozza, Piergiorgio [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Salina, Gaetano [Phy. Dep. Univ. ' Tor Vergata' , Tor Vergata Sect. INFN (Italy); Galper, Arkady [Moscow Engineering and Physics Institute (Russian Federation); Korotkov, Mikhail [Moscow Engineering and Physics Institute (Russian Federation); Popov, Alexander [Moscow Engineering and Physics Institute (Russian Federation)

    2007-03-01

    Silicon Photomultipliers (Si-PM) consist of an array of semiconductor photodiodes joint on the common substrate and operating in limited geiger mode. A new generation of Si-PM is currently under test in INFN Rome Tor Vergata facilities: they consist of a 5625 element, 3*3mm{sup 2} array with an improved light response. These elements have been characterized. Furthermore, a functional model of the Si-PM has been developed to be used in a VLSI development of front-end electronics.

  4. On modeling the CNC end milling characteristics of Al-7075/WC powder metallurgy composites

    Science.gov (United States)

    Hanuman, N. S. V. N.; Rao, P. Gangadhara; Kumar, B. Sudheer; Karthik, N.

    2017-07-01

    Surface finish and material removal rate are two important factors in the manufacturing which affect acceptability of the product which in turn reflects on the profitability of the organization. The worth of the production setup to produce the components with high material removal rate (MRR) without sacrificing the surface requirements can play vital role in sustainability and profitability of the organization. In this paper, the effect of process parameters on metal removal rate and surface roughness has been investigated in milling of Al7075-MMC with WC as reinforcement element. Cutting speed, feed and depth of cut have been taken as input factors in three level response surface methodologies used for experimentation. Mathematical models have been developed using response surface methodology to predict surface finish, and metal removal rate in term of machining parameters. Depth of cut and feed rate are found to be a dominant parameter for surface roughness; whereas feed rate mainly affects the metal removal rate. The results of mathematical models have been compared with the experimental and found to be in good agreement. The results of predicted model can be used in selection of process parameters to insure desired quality and improved productivity.

  5. Multiphysical model of heterogenous flow moving along а channel of variable cross-section

    Directory of Open Access Journals (Sweden)

    М. А. Васильева

    2017-10-01

    Full Text Available The article deals with the problem aimed at solving the fundamental problems of developing effective methods and tools for designing, controlling and managing the stream of fluid flowing in variable-section pipelines intended for the production of pumping equipment, medical devices and used in such areas of industry as mining, chemical, food production, etc. Execution of simulation modelling of flow motion according to the scheme of twisted paddle static mixer allows to estimate the efficiency of mixing by calculating the trajectory and velocities of the suspended particles going through the mixer, and also to estimate the pressure drop on the hydraulic flow resistance. The model examines the mixing of solids dissolved in a liquid at room temperature. To visualize the process of distributing the mixture particles over the cross-section and analyzing the mixing efficiency, the Poincaréplot module of the COMSOL Multiphysics software environment was used. For the first time, a multi-physical stream of heterogeneous flow model has been developed that describes in detail the physical state of the fluid at all points of the considered section at the initial time, takes into account the design parameters of the channel (orientation, dimensions, material, etc., specifies the laws of variation of the parameters at the boundaries of the calculated section in conditions of the wave change in the internal section of the working chamber-channel of the inductive peristaltic pumping unit under the influence of the energy of the magnetic field.

  6. Performance of a New Model for Predicting End of Flowering Date (bbch 69) of Grapevine (Vitis Vinifera L.)

    Science.gov (United States)

    Gentilucci, Matteo

    2017-04-01

    The end of flowering date (BBCH 69) is an important phenological stage for grapevine (Vitis Vinifera L.), in fact up to this date the growth is focused on the plant and gradually passes on the berries through fruit set. The aim of this study is to perform a model to predict the date of the end of flowering (BBCH69) for some grapevine varieties. This research carried out using three cultivars of grapevine (Maceratino, Montepulciano, Sangiovese) in three different locations (Macerata, Morrovalle and Potenza Picena), places of an equal number of wine farms for the time interval between 2006 and 2013. In order to have reliable temperatures for each location, the data of 6 weather stations near these farms have been interpolated using cokriging methods with elevation as independent variable. The procedure to predict the end of flowering date starts with an investigation of cardinal temperatures typical of each grapevine cultivar. In fact the analysis is characterized by four temperature thresholds (cardinals): minimum activity temperature (TCmin = below this temperature there is no growth for the plant), lower optimal temperature (TLopt = above this temperature there is maximum growth), upper optimal temperature (TUopt = below this temperature there is maximum growth) and maximum activity temperature (TC max = above this temperature there is no growth). Thus this model take into consideration maximum, mean and minimum daily temperatures of each location, relating them with the four above mentioned cultivar temperature thresholds. In this way it has been obtained some possible cases (32) corresponding to as many equations, depending on the position of temperatures compared with the thresholds, in order to calculate the amount of growing degree units (GDU) for each day. Several iterative tests (about 1000 for each cultivar) have been performed, changing the values of temperature thresholds and GDU in order to find the best possible combination which minimizes error

  7. Optimal cross-sectional sampling for river modelling with bridges: An information theory-based method

    International Nuclear Information System (INIS)

    Ridolfi, E.; Napolitano, F.; Alfonso, L.; Di Baldassarre, G.

    2016-01-01

    The description of river topography has a crucial role in accurate one-dimensional (1D) hydraulic modelling. Specifically, cross-sectional data define the riverbed elevation, the flood-prone area, and thus, the hydraulic behavior of the river. Here, the problem of the optimal cross-sectional spacing is solved through an information theory-based concept. The optimal subset of locations is the one with the maximum information content and the minimum amount of redundancy. The original contribution is the introduction of a methodology to sample river cross sections in the presence of bridges. The approach is tested on the Grosseto River (IT) and is compared to existing guidelines. The results show that the information theory-based approach can support traditional methods to estimate rivers’ cross-sectional spacing.

  8. Optimal cross-sectional sampling for river modelling with bridges: An information theory-based method

    Energy Technology Data Exchange (ETDEWEB)

    Ridolfi, E.; Napolitano, F., E-mail: francesco.napolitano@uniroma1.it [Sapienza Università di Roma, Dipartimento di Ingegneria Civile, Edile e Ambientale (Italy); Alfonso, L. [Hydroinformatics Chair Group, UNESCO-IHE, Delft (Netherlands); Di Baldassarre, G. [Department of Earth Sciences, Program for Air, Water and Landscape Sciences, Uppsala University (Sweden)

    2016-06-08

    The description of river topography has a crucial role in accurate one-dimensional (1D) hydraulic modelling. Specifically, cross-sectional data define the riverbed elevation, the flood-prone area, and thus, the hydraulic behavior of the river. Here, the problem of the optimal cross-sectional spacing is solved through an information theory-based concept. The optimal subset of locations is the one with the maximum information content and the minimum amount of redundancy. The original contribution is the introduction of a methodology to sample river cross sections in the presence of bridges. The approach is tested on the Grosseto River (IT) and is compared to existing guidelines. The results show that the information theory-based approach can support traditional methods to estimate rivers’ cross-sectional spacing.

  9. Extension of non-linear beam models with deformable cross sections

    Science.gov (United States)

    Sokolov, I.; Krylov, S.; Harari, I.

    2015-12-01

    Geometrically exact beam theory is extended to allow distortion of the cross section. We present an appropriate set of cross-section basis functions and provide physical insight to the cross-sectional distortion from linear elastostatics. The beam formulation in terms of material (back-rotated) beam internal force resultants and work-conjugate kinematic quantities emerges naturally from the material description of virtual work of constrained finite elasticity. The inclusion of cross-sectional deformation allows straightforward application of three-dimensional constitutive laws in the beam formulation. Beam counterparts of applied loads are expressed in terms of the original three-dimensional data. Special attention is paid to the treatment of the applied stress, keeping in mind applications such as hydrogel actuators under environmental stimuli or devices made of electroactive polymers. Numerical comparisons show the ability of the beam model to reproduce finite elasticity results with good efficiency.

  10. Right Heart End-Systolic Remodeling Index Strongly Predicts Outcomes in Pulmonary Arterial Hypertension: Comparison With Validated Models.

    Science.gov (United States)

    Amsallem, Myriam; Sweatt, Andrew J; Aymami, Marie C; Kuznetsova, Tatiana; Selej, Mona; Lu, HongQuan; Mercier, Olaf; Fadel, Elie; Schnittger, Ingela; McConnell, Michael V; Rabinovitch, Marlene; Zamanian, Roham T; Haddad, Francois

    2017-06-01

    Right ventricular (RV) end-systolic dimensions provide information on both size and function. We investigated whether an internally scaled index of end-systolic dimension is incremental to well-validated prognostic scores in pulmonary arterial hypertension. From 2005 to 2014, 228 patients with pulmonary arterial hypertension were prospectively enrolled. RV end-systolic remodeling index (RVESRI) was defined by lateral length divided by septal height. The incremental values of RV free wall longitudinal strain and RVESRI to risk scores were determined. Mean age was 49±14 years, 78% were female, 33% had connective tissue disease, 52% were in New York Heart Association class ≥III, and mean pulmonary vascular resistance was 11.2±6.4 WU. RVESRI and right atrial area were strongly connected to the other right heart metrics. Three zones of adaptation (adapted, maladapted, and severely maladapted) were identified based on the RVESRI to RV systolic pressure relationship. During a mean follow-up of 3.9±2.4 years, the primary end point of death, transplant, or admission for heart failure was reached in 88 patients. RVESRI was incremental to risk prediction scores in pulmonary arterial hypertension, including the Registry to Evaluate Early and Long-Term PAH Disease Management score, the Pulmonary Hypertension Connection equation, and the Mayo Clinic model. Using multivariable analysis, New York Heart Association class III/IV, RVESRI, and log NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) were retained (χ 2 , 62.2; P right heart metrics, RVESRI demonstrated the best test-retest characteristics. RVESRI is a simple reproducible prognostic marker in patients with pulmonary arterial hypertension. © 2017 American Heart Association, Inc.

  11. Estimating the Cost of Preeclampsia in the Healthcare System: Cross-Sectional Study Using Data From SCOPE Study (Screening for Pregnancy End Points).

    Science.gov (United States)

    Fox, Aimée; McHugh, Sheena; Browne, John; Kenny, Louise C; Fitzgerald, Anthony; Khashan, Ali S; Dempsey, Eugene; Fahy, Ciara; O'Neill, Ciaran; Kearney, Patricia M

    2017-12-01

    To estimate the cost of preeclampsia from the national health payer's perspective using secondary data from the SCOPE study (Screening for Pregnancy End Points). SCOPE is an international observational prospective study of healthy nulliparous women with singleton pregnancies. Using data from the Irish cohort recruited between November 2008 and February 2011, all women with preeclampsia and a 10% random sample of women without preeclampsia were selected. Additional health service use data were extracted from the consenting participants' medical records for maternity services which were not included in SCOPE. Unit costs were based on estimates from 3 existing Irish studies. Costs were extrapolated to a national level using a prevalence rate of 5% to 7% among nulliparous pregnancies. Within the cohort of 1774 women, 68 developed preeclampsia (3.8%) and 171 women were randomly selected as controls. Women with preeclampsia used higher levels of maternity services. The average cost of a pregnancy complicated by preeclampsia was €5243 per case compared with €2452 per case for an uncomplicated pregnancy. The national cost of preeclampsia is between €6.5 and €9.1 million per annum based on the 5% to 7% prevalence rate. Postpartum care was the largest contributor to these costs (€4.9-€6.9 million), followed by antepartum care (€0.9-€1.3 million) and peripartum care (€0.6-€0.7 million). Women with preeclampsia generate significantly higher maternity costs than women without preeclampsia. These cost estimates will allow policy-makers to efficiently allocate resources for this pregnancy-specific condition. Moreover, these estimates are useful for future research assessing the cost-effectiveness of preeclampsia screening and treatment. © 2017 American Heart Association, Inc.

  12. Analysis of Phenix End-of-Life asymmetry test with multi-dimensional pool modeling of MARS-LMR code

    International Nuclear Information System (INIS)

    Jeong, H.-Y.; Ha, K.-S.; Choi, C.-W.; Park, M.-G.

    2015-01-01

    Highlights: • Pool behaviors under asymmetrical condition in an SFR were evaluated with MARS-LMR. • The Phenix asymmetry test was analyzed one-dimensionally and multi-dimensionally. • One-dimensional modeling has limitation to predict the cold pool temperature. • Multi-dimensional modeling shows improved prediction of stratification and mixing. - Abstract: The understanding of complicated pool behaviors and its modeling is essential for the design and safety analysis of a pool-type Sodium-cooled Fast Reactor. One of the remarkable recent efforts on the study of pool thermal–hydraulic behaviors is the asymmetrical test performed as a part of Phenix End-of-Life tests by the CEA. To evaluate the performance of MARS-LMR code, which is a key system analysis tool for the design of an SFR in Korea, in the prediction of thermal hydraulic behaviors during an asymmetrical condition, the Phenix asymmetry test is analyzed with MARS-LMR in the present study. Pool regions are modeled with two different approaches, one-dimensional modeling and multi-dimensional one, and the prediction results are analyzed to identify the appropriateness of each modeling method. The prediction with one-dimensional pool modeling shows a large deviation from the measured data at the early stage of the test, which suggests limitations to describe the complicated thermal–hydraulic phenomena. When the pool regions are modeled multi-dimensionally, the prediction gives improved results quite a bit. This improvement is explained by the enhanced modeling of pool mixing with the multi-dimensional modeling. On the basis of the results from the present study, it is concluded that an accurate modeling of pool thermal–hydraulics is a prerequisite for the evaluation of design performance and safety margin quantification in the future SFR developments

  13. MATHEMATICAL MODEL OF POWER CONSUMPTION FOR SOME OIL PIPE-LINE SECTIONS WITH POOR OPERATIONAL STABILITY

    Directory of Open Access Journals (Sweden)

    J. N. Kolesnik

    2005-01-01

    Full Text Available Mathematical model of power consumption for technologically completed and non-completed oil pipe-line sections with poor operational stability has been developed on the basis of daily indices concerning oil transportation regimes. The model permits to take into account tendencies in power consumption under various time prediction cycles and ranges of oil freight turnover, changes in the bulk and characteristics of the transported oil, configuration and design parameters of oil pipe-line.

  14. Improvement of Axial Reflector Cross Section Generation Model for PWR Core Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Cheon Bo; Lee, Kyung Hoon; Cho, Jin Young [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    This paper covers the study for improvement of axial reflector XS generation model. In the next section, the improved 1D core model is represented in detail. Reflector XS generated by the improved model is compared to that of the conventional model in the third section. Nuclear design parameters generated by these two XS sets are also covered in that section. Significant of this study is discussed in the last section. Two-step procedure has been regarded as the most practical approach for reactor core designs because it offers core design parameters quite rapidly within acceptable range. Thus this approach is adopted for SMART (System-integrated Modular Advanced Reac- Tor) core design in KAERI with the DeCART2D1.1/ MASTER4.0 (hereafter noted as DeCART2D/ MASTER) code system. Within the framework of the two-step procedure based SMART core design, various researches have been studied to improve the core design reliability and efficiency. One of them is improvement of reflector cross section (XS) generation models. While the conventional FA/reflector two-node model used for most core designs to generate reflector XS cannot consider the actual configuration of fuel rods that intersect at right angles to axial reflectors, the revised model reflects the axial fuel configuration by introducing the radially simplified core model. The significance of the model revision is evaluated by observing HGC generated by DeCART2D, reflector XS, and core design parameters generated by adopting the two models. And it is verified that about 30 ppm CBC error can be reduced and maximum Fq error decreases from about 6 % to 2.5 % by applying the revised model. Error of AO and axial power shapes are also reduced significantly. Therefore it can be concluded that the simplified 1D core model improves the accuracy of the axial reflector XS and leads to the two-step procedure reliability enhancement. Since it is hard for core designs to be free from the two-step approach, it is necessary to find

  15. M5 model tree based predictive modeling of road accidents on non-urban sections of highways in India.

    Science.gov (United States)

    Singh, Gyanendra; Sachdeva, S N; Pal, Mahesh

    2016-11-01

    This work examines the application of M5 model tree and conventionally used fixed/random effect negative binomial (FENB/RENB) regression models for accident prediction on non-urban sections of highway in Haryana (India). Road accident data for a period of 2-6 years on different sections of 8 National and State Highways in Haryana was collected from police records. Data related to road geometry, traffic and road environment related variables was collected through field studies. Total two hundred and twenty two data points were gathered by dividing highways into sections with certain uniform geometric characteristics. For prediction of accident frequencies using fifteen input parameters, two modeling approaches: FENB/RENB regression and M5 model tree were used. Results suggest that both models perform comparably well in terms of correlation coefficient and root mean square error values. M5 model tree provides simple linear equations that are easy to interpret and provide better insight, indicating that this approach can effectively be used as an alternative to RENB approach if the sole purpose is to predict motor vehicle crashes. Sensitivity analysis using M5 model tree also suggests that its results reflect the physical conditions. Both models clearly indicate that to improve safety on Indian highways minor accesses to the highways need to be properly designed and controlled, the service roads to be made functional and dispersion of speeds is to be brought down. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Differences in nulliparous caesarean section rates across models of care: a decomposition analysis.

    LENUS (Irish Health Repository)

    Brick, Aoife

    2016-01-01

    To evaluate the extent of the difference in elective (ELCS) and emergency (EMCS) caesarean section (CS) rates between nulliparous women in public maternity hospitals in Ireland by model of care, and to quantify the contribution of maternal, clinical, and hospital characteristics in explaining the difference in the rates.

  17. Using the mean approach in pooling cross-section and time series data for regression modelling

    International Nuclear Information System (INIS)

    Nuamah, N.N.N.N.

    1989-12-01

    The mean approach is one of the methods for pooling cross section and time series data for mathematical-statistical modelling. Though a simple approach, its results are sometimes paradoxical in nature. However, researchers still continue using it for its simplicity. Here, the paper investigates the nature and source of such unwanted phenomena. (author). 7 refs

  18. Guest Editorial Special Section on Systems of Power Converters: Design, Modeling, Control, and Implementation

    DEFF Research Database (Denmark)

    Liu, Wenxin; Guerrero, Josep M.; Kim, Jang Mok

    2017-01-01

    In this Special Section on Systems of Power Converters: Design, Modeling, Control, and Implementation, we have 11 high-quality papers approved for publication that cover the following three topics. 1) Converter Design and Operation. 2) Subsystem-Level Applications. 3) System-Level Applications. T....... These topics and the corresponding papers are summarized....

  19. Modeling of composite coupling technology for oil-gas pipeline section resource-saving repair

    Science.gov (United States)

    Donkova, Irina; Yakubovskiy, Yuriy; Kruglov, Mikhail

    2017-10-01

    The article presents a variant of modeling and calculation of a main pipeline repair section with a composite coupling installation. This section is presented in a shape of a composite cylindrical shell. The aim of this work is mathematical modeling and study of main pipeline reconstruction section stress-strain state (SSS). There has been given a description of a structure deformation mathematical model. Based on physical relations of elasticity, integral characteristics of rigidity for each layer of a two-layer pipe section have been obtained. With the help of the systems of forces and moments which affect the layers differential equations for the first and second layer (pipeline and coupling) have been obtained. The study of the SSS has been conducted using the statements and hypotheses of the composite structures deformation theory with consideration of interlayer joint stresses. The relations to describe the work of the joint have been stated. Boundary conditions for each layer have been formulated. To describe the deformation of the composite coupling with consideration of the composite cylindrical shells theory a mathematical model in the form of a system of differential equations in displacements and boundary conditions has been obtained. Calculation of a two-layer cylindrical shell under the action of an axisymmetric load has been accomplished.

  20. HADES. A computer code for fast neutron cross section from the Optical Model

    International Nuclear Information System (INIS)

    Guasp, J.; Navarro, C.

    1973-01-01

    A FORTRAN V computer code for UNIVAC 1108/6 using a local Optical Model with spin-orbit interaction is described. The code calculates fast neutron cross sections, angular distribution, and Legendre moments for heavy and intermediate spherical nuclei. It allows for the possibility of automatic variation of potential parameters for experimental data fitting. (Author) 55 refs

  1. Thymoquinone protects end organs from abdominal aorta ischemia/reperfusion injury in a rat model

    Directory of Open Access Journals (Sweden)

    Mehmet Salih Aydin

    2015-02-01

    Full Text Available Introduction: Previous studies have demonstrated that thymoquinone has protective effects against ischemia reperfusion injury to various organs like lungs, kidneys and liver in different experimental models. Objective: We aimed to determine whether thymoquinone has favorable effects on lung, renal, heart tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury. Methods: Thirty rats were divided into three groups as sham (n=10, control (n=10 and thymoquinone (TQ treatment group (n=10. Control and TQ-treatment groups underwent abdominal aorta ischemia for 45 minutes followed by a 120-min period of reperfusion. In the TQ-treatment group, thymoquinone was given 5 minutes. before reperfusion at a dose of 20 mg/kg via an intraperitoneal route. Total antioxidant capacity, total oxidative status (TOS, and oxidative stress index (OSI in blood serum were measured and lung, kidney, and heart tissue histopathology were evaluated with light microscopy. Results: Total oxidative status and oxidative stress index activity in blood samples were statistically higher in the control group compared to the sham and TQ-treatment groups (P<0.001 for TOS and OSI. Control group injury scores were statistically higher compared to sham and TQ-treatment groups (P<0.001 for all comparisons. Conclusion: Thymoquinone administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta ischemia-reperfusion rat model.

  2. Application of equivalent resistance to simplification of Sutong Bridge piers in tidal river section modeling

    Directory of Open Access Journals (Sweden)

    Lei Tang

    2012-09-01

    Full Text Available This paper describes some details and procedural steps in the equivalent resistance (E-R method for simplifying the pier group of the Sutong Bridge, which is located on the tidal reach of the lower Yangtze River, in Jiangsu Province. Using a two-dimensional tidal current numerical model, three different models were established: the non-bridge pier model, original bridge pier model, and simplified bridge pier model. The difference in hydrodynamic parameters, including water level, velocity, and diversion ratio, as well as time efficiency between these three models is discussed in detail. The results show that simplifying the pier group using the E-R method influences the water level and velocity near the piers, but has no influence on the diversion ratio of each cross-section of the Xuliujing reach located in the lower Yangtze River. Furthermore, the simplified bridge pier model takes half the calculation time that the original bridge pier model needs. Thus, it is concluded that the E-R method can be use to simplify bridge piers in tidal river section modeling reasonably and efficiently.

  3. Prevalence and early detection of oral fungal infection: a cross-sectional controlled study in a group of Swedish end-stage renal disease patients.

    Science.gov (United States)

    Thorman, Royne; Neovius, Martin; Hylander, Britta

    2009-01-01

    Early detection and treatment of local oral fungal infection (OFI) minimize the risk of overgrowth and more serious complications such as invasive infections. Generalized fungal infection increases both morbidity and mortality in end-stage renal disease (ESRD) patients. This study reports the prevalence of ongoing OFI in patients with ESRD and presents correlations with dental microbial plaque formation and mouth dryness. It also describes how oral fungal growth correlates with oral lesions associated with fungal infection. From March 2007 to October 2008, 93 ESRD patients and 45 age- and gender-matched controls were consecutively asked to participate in the study. In total, 34 patients were treated with peritoneal dialysis (PD) and 59 with haemodialysis (HD). OFI was diagnosed by taking two smear layers from the buccal mucosa. The samples from each side of the mouth were stained with the periodic acid Schiff (PAS) method. The associations between histological findings, age, gender, type of dialysis treatment, tobacco habits, self-experienced mouth dryness, taste disturbances, dental plaque and gingivitis were investigated. The presence of erythematous oral stomatitis, membranous candidiasis and angular cheilitis was noted to clarify how the presence of fungal hyphae correlate with oral lesions associated with OFI. OFI was found in 32% of the ESRD patients and 11% of the controls (p=0.007). An extensive OFI, defined as frequent fungal hyphae formations in oral mucosal smear layers, was found in 3% of the PD and 17% of the HD patients. Oral lesions, defined as clinical signs associated with OFI such as erythematous oral stomatitis, membranous candidiasis or angular cheilitis, were found in 37% of the patients with OFI, while 5% of the patients without findings of fungal infection presented oral lesions associated with OFI (p=0.0002). Furthermore, patients with self-reported mouth dryness were three times more likely (p=0.02) to be diagnosed with OFI. ESRD patients

  4. Proposition end validation of regressive mathematical models to estimate maximum dynamic force from predictive neuromuscular variables

    Directory of Open Access Journals (Sweden)

    Ney Marcos da Luz Pedroso

    2002-12-01

    Full Text Available The purpose of this study was to propose and validate mathematical models to estimate the Maximum Dynamic Force (MDF from predictive neuromuscular variables, and to verify if they are upheld by a statistic process of cross-validation, The sample consisted of 75 women, 18 to 30 years of age, and well acquainted with Resistance Weight Exercises (RWE. The sample was divided into two groups: group I (n=55 utilized in the statistical process for developing the proposed mathematical models, and group II (n=20 utilized for the process of validation of those models. independent variables were the neuromuscular Maximum Repetitions (MR executed in the Frontal Pull (FP and Knee Flexion (KF exercises. The dependent variable was MDF measured on 10 RWE apparatus by means of the 1 MR test, according to the Moura et al. protocol (1997. Multiple Regression Analysis was used to produce proposed mathematical models, and cross-validation (Lohman, 1992, with signifi cance set at p RESUMO Neste estudo buscou-se propor e validar modelos matemáticos para estimativa da Força Dinâmica Máxima (FDM a partir de variáveis preditivas neuromusculares, e verifi car se estes são sustentados através de um processo estatístico de validação cruzada. Para tal selecionou-se uma amostra composta por 75 mulheres na faixa etária 18 a 30 anos, todas familiarizadas com Exercícios Resistidos com Pesos (ERP. A amostra foi seccionada em dois grupos: grupo I (n=55 utilizado no processo estatístico de proposição dos modelos matemáticos, e grupo II (n=20 utilizado para o processo de validação destes modelos. As variáveis independentes foram as neuromusculares Repetições Máximas (RMs realizadas nos exercícios Puxada Frontal (PF e Flexão de Joelhos (FJ. A variável dependente foi a FDM mensurada em 10 aparelhos de ERP através do teste de 1RM, protocolo de Moura et al. (1997. Utilizou-se da Análise de Regressão Múltipla para proposição dos modelos matemáticos, e para

  5. Research Spotlight: Model suggests path to ending the ongoing Haitian cholera epidemic

    Science.gov (United States)

    Schultz, Colin

    2011-05-01

    Since early November 2010 a deadly cholera epidemic has been spreading across the Caribbean nation of Haiti, killing thousands of people and infecting hundreds of thousands. While infection rates are being actively monitored, health organizations have been left without a clear understanding of exactly how the disease has spread across Haiti. Cholera can spread through exposure to contaminated water, and the disease travels over long distances if an infected individual moves around the country. Using representations of these two predominant dispersion mechanisms, along with information on the size of the susceptible population, the number of infected individuals, and the aquatic concentration of the cholera-causing bacteria for more than 500 communities, Bertuzzo et al. designed a model that was able to accurately reproduce the progression of the Haitian cholera epidemic. (Geophysical Research Letters, doi:10.1029/2011GL046823, 2011)

  6. Evaluating adaptation options for urban flooding based on new high-end emission scenario regional climate model simulations

    DEFF Research Database (Denmark)

    Arnbjerg-Nielsen, Karsten; Leonardsen, L.; Madsen, Henrik

    2015-01-01

    Climate change adaptation studies on urban flooding are often based on a model chain approach from climate forcing scenarios to analysis of adaptation measures. Previous analyses of climate change impacts in Copenhagen, Denmark, were supplemented by 2 high-end scenario simulations. These include...... a regional climate model projection forced to a global temperature increase of 6 degrees C in 2100 as well as a projection based on a high radiative forcing scenario (RCP8.5). With these scenarios, projected impacts of extreme precipitation increase significantly. For extreme sea surges, the impacts do...... not seem to change substantially compared to currently applied projections. The flood risk (in terms of expected annual damage, EAD) from sea surge is likely to increase by more than 2 orders of magnitude in 2100 compared to the present cost. The risk from pluvial flooding in 2000 is likely to increase...

  7. Desired lifetime and end-of-life desires across adulthood from 20 to 90: a dual-source information model.

    Science.gov (United States)

    Lang, Frieder R; Baltes, Paul B; Wagner, Gert G

    2007-09-01

    How long do people want to live, and how does scientific research on aging affect such desires? A dual-source information model proposes that aging expectations and desires are informed differently by two sources: personal experiences on the one hand, and scientific and societal influences on the other. Two studies with independent German national samples explored desires regarding length of life and end of life among adults between the ages of 20 and 90. FINDINGS ARE: First, desired lifetime is consistent at around 85 years with few age differences. Second, experimental induction of good or bad news from research on aging has little effect in Study 1. Third, interest in science has moderating effects on desired lifetime in Study 2. Fourth, there is a high prevalence of a strong desire to control the "when and how" of one's death, although only 11% of the individuals completed a living will. Findings are consistent with the dual-source information model.

  8. The Circulating Level of Soluble Receptor for Advanced Glycation End Products Displays Different Patterns in Ulcerative Colitis and Crohn's Disease: A Cross-Sectional Study.

    Science.gov (United States)

    Ciccocioppo, Rachele; Imbesi, Venerina; Betti, Elena; Boccaccio, Vincenzo; Kruzliak, Peter; Gallia, Alessandra; Cangemi, Giuseppina Cristina; Maffe, Gabriella Carnevale; Vanoli, Alessandro; Merante, Serena; De Amici, Mara; Falcone, Colomba; Klersy, Catherine; Corazza, Gino Roberto

    2015-08-01

    RAGE is a transmembrane receptor expressed on immune and endothelial cells, whose binding with its ligands, the S100 calgranulins, leads to chronic inflammation. Conversely, its soluble form (sRAGE) plays a protective role by acting as a decoy. We carried out a cross-sectional analysis of the sRAGE and S100A12 serum levels in patients with Crohn's disease (CD) and ulcerative colitis (UC) and searched for a correlation with clinical and biological markers of activity. We enrolled 60 CD, 67 UC patients, and 66 controls (all adults). Disease activity was scored through the clinical, endoscopic, and histologic indexes of severity, whilst disease location and behaviour were assessed according to the Montreal classification. In all cases, the levels of serum sRAGE, S100A12, C-reactive protein, and faecal calprotectin were measured. sRAGE levels were significantly lower in UC, both active and inactive, than in controls and CD (817.35, range 437.3-1449; 1211, range 843.7-1618; 1207.5, range 743.15-1875.75; P < 0.05 for both), and inversely correlated with clinical and endoscopic indexes of activity in both IBD groups (P < 0.05 for all) and with the histologic score in the CD group. Moreover, those CD patients with a penetrating behaviour showed a significant reduction in both sRAGE (P = 0.006) and S100A12 (P = 0.034) as compared to those with an inflammatory/stricturing pattern. Although S100A12 levels were not found up-regulated, a negative correlation appeared evident with the clinical (r = -0.38) and endoscopic (r = -0.32) indexes of activity in UC and CD, respectively. These data suggest a different role for RAGE in CD and UC, and a potential use of sRAGE as a new biomarker.

  9. High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study.

    Science.gov (United States)

    Prodam, Flavia; Ricotti, Roberta; Agarla, Valentina; Parlamento, Silvia; Genoni, Giulia; Balossini, Caterina; Walker, Gillian Elisabeth; Aimaretti, Gianluca; Bona, Gianni; Bellone, Simonetta

    2013-02-20

    The hypothalamic-pituitary-adrenal (HPA) axis, and in particular cortisol, has been reported to be involved in obesity-associated metabolic disturbances in adults and in selected populations of adolescents. The aim of this study was to investigate the association between morning adrenocorticotropic hormone (ACTH) and cortisol levels and cardiovascular risk factors in overweight or obese Caucasian children and adolescents. This cross-sectional study of 450 obese children and adolescents (aged 4 to 18 years) was performed in a tertiary referral center. ACTH, cortisol, cardiovascular risk factors (fasting and post-challenge glucose, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglycerides, and hypertension) and insulin resistance were evaluated. All analyses were corrected for confounding factors (sex, age, puberty, body mass index), and odds ratios were determined. ACTH and cortisol levels were positively associated with systolic and diastolic blood pressure, triglycerides, fasting glucose and insulin resistance. Cortisol, but not ACTH, was also positively associated with LDL-cholesterol. When adjusted for confounding factors, an association between ACTH and 2 h post-oral glucose tolerance test glucose was revealed. After stratification according to cardiovascular risk factors and adjustment for possible confounding factors, ACTH levels were significantly higher in subjects with triglycerides ≥90th percentile (P cortisol levels were found in subjects with blood pressure ≥95th percentile and LDL-cholesterol ≥90th percentile. Overall, the highest tertiles of ACTH (>5.92 pmol/l) and cortisol (>383.5 nmol/l) although within the normal range were associated with increases in cardiovascular risk factors in this population. In obese children and adolescents, high morning ACTH and cortisol levels are associated with cardiovascular risk factors. High ACTH levels are associated with high triglyceride levels and hyperglycemia

  10. Surface Generation Modeling in Ball Nose End Milling: a review of relevant literature

    DEFF Research Database (Denmark)

    Bissacco, Giuliano

    One of the most common metal removal operation used in industry is the milling process. This machining process is well known since the beginning of last century and has experienced, along the years, many improvements of the basic technology, as concerns tools, machine tools, coolants/lubricants, ......One of the most common metal removal operation used in industry is the milling process. This machining process is well known since the beginning of last century and has experienced, along the years, many improvements of the basic technology, as concerns tools, machine tools, coolants....../lubricants, milling strategies and controls. However, most of the times, the selection of the cutting parameters in order to achieve the best result on the manufactured part is still mostly an empirical process, based on the experience of engineers and technicians and very often the parameters first selected have...... to be adjusted afterwards. Nevertheless, many efforts have been done during the last 50 years in order to realize prediction tools for machining processes and particularly for conventional turning and milling operations. Most of these models aim at prediction of cutting forces tool wear and tool life. However...

  11. Thymoquinone protects end organs from abdominal aorta ischemia/reperfusion injury in a rat model.

    Science.gov (United States)

    Aydin, Mehmet Salih; Kocarslan, Aydemir; Kocarslan, Sezen; Kucuk, Ahmet; Eser, İrfan; Sezen, Hatice; Buyukfirat, Evren; Hazar, Abdussemet

    2015-01-01

    Previous studies have demonstrated that thymoquinone has protective effects against ischemia reperfusion injury to various organs like lungs, kidneys and liver in different experimental models. We aimed to determine whether thymoquinone has favorable effects on lung, renal, heart tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury. Thirty rats were divided into three groups as sham (n=10), control (n=10) and thymoquinone (TQ) treatment group (n=10). Control and TQ-treatment groups underwent abdominal aorta ischemia for 45 minutes followed by a 120-min period of reperfusion. In the TQ-treatment group, thymoquinone was given 5 minutes. before reperfusion at a dose of 20 mg/kg via an intraperitoneal route. Total antioxidant capacity, total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured and lung, kidney, and heart tissue histopathology were evaluated with light microscopy. Total oxidative status and oxidative stress index activity in blood samples were statistically higher in the control group compared to the sham and TQ-treatment groups (POSI). Control group injury scores were statistically higher compared to sham and TQ-treatment groups (Pmodel.

  12. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    Directory of Open Access Journals (Sweden)

    Marcin Luczak

    2014-01-01

    Full Text Available This paper presents selected results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study of the structural dynamics of a bend-twist coupled full scale section of a wind turbine blade structure. The main goal of the conducted research is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set of model parameters was selected for the model updating process. Design of experiment and response surface method was implemented to find values of model parameters yielding results closest to the experimental. The updated finite element model is producing results more consistent with the measurement outcomes.

  13. Study on Vehicle Track Model in Road Curved Section Based on Vehicle Dynamic Characteristics

    Directory of Open Access Journals (Sweden)

    Ren Yuan-Yuan

    2012-01-01

    Full Text Available Plenty of experiments and data analysis of vehicle track type in road curved section show that the deviation and the crossing characteristics of vehicle track paths are directly related to the driving stability and security. In this connection, the concept of driving trajectory in curved section was proposed, six track types were classified and defined, and furthermore their characteristic features were determined. Most importantly, considering curve geometry and vehicle dynamic characteristics, each trajectory model was established, respectively, and the optimum driving trajectory models were finally determined based on the crucial factors of vehicle yaw rate, which was also the most important factor that impacts vehicle’s handling stability. Through it all, MATLAB was used to simulate and verify the correctness of models. Finally, this paper comes to the conclusion that normal trajectory and cutting trajectory are the optimum driving trajectories.

  14. Modeling and Analysis of a Piezoelectric Energy Harvester with Varying Cross-Sectional Area

    Directory of Open Access Journals (Sweden)

    Maiara Rosa

    2014-01-01

    Full Text Available This paper reports on the modeling and on the experimental verification of electromechanically coupled beams with varying cross-sectional area for piezoelectric energy harvesting. The governing equations are formulated using the Rayleigh-Ritz method and Euler-Bernoulli assumptions. A load resistance is considered in the electrical domain for the estimate of the electric power output of each geometric configuration. The model is first verified against the analytical results for a rectangular bimorph with tip mass reported in the literature. The experimental verification of the model is also reported for a tapered bimorph cantilever with tip mass. The effects of varying cross-sectional area and tip mass on the electromechanical behavior of piezoelectric energy harvesters are also discussed. An issue related to the estimation of the optimal load resistance (that gives the maximum power output on beam shape optimization problems is also discussed.

  15. [Sectional structure of a tree. Model analysis of the vertical biomass distribution].

    Science.gov (United States)

    Galitskiĭ, V V

    2010-01-01

    A model has been proposed for the architecture of a tree in which virtual trees appear rhythmically on the treetop. Each consecutive virtual tree is a part of the previous tree. The difference between two adjacent virtual trees is a section--an element of the real tree structure. In case of a spruce, the section represents a verticil of a stem with the corresponding internode. Dynamics of a photosynthesizing part of the physiologically active biomass of each section differ from the corresponding dynamics of the virtual trees and the whole real tree. If the tree biomass dynamics has a sigma-shaped form, then the section dynamics have to be bell-shaped. It means that the lower stem should accordingly become bare, which is typically observed in nature. Model analysis reveals the limiting, in the age, form of trees to be an "umbrella". It can be observed in nature and is an outcome of physical limitation of the tree height combined with the sigma-shaped form of the tree biomass dynamics. Variation of model parameters provides for various forms of the tree biomass distribution along the height, which can be associated with certain biological species of trees.

  16. Biochemical Kinetics Model of DSB Repair and GammaH2AX FOCI by Non-homologous End Joining

    Science.gov (United States)

    Cucinotta, Francis, A.; Pluth, Janice M.; Anderson, Jennifer A.; Harper, Jane V.; O'Neill, Peter

    2007-01-01

    We developed a biochemical kinetics approach to describe the repair of double strand breaks (DSB) produced by low LET radiation by modeling molecular events associated with the mechanisms of non-homologous end-joining (NHEJ). A system of coupled non-linear ordinary differential equations describes the induction of DSB and activation pathways for major NHEJ components including Ku(sub 70/80), DNA-PK(sub cs), and the Ligase IV-XRCC4 hetero-dimer. The autophosphorylation of DNA-PK(sub cs and subsequent induction of gamma-H2AX foci observed after ionizing radiation exposure were modeled. A two-step model of DNA-PK(sub cs) regulation of repair was developed with the initial step allowing access of other NHEJ components to breaks, and a second step limiting access to Ligase IV-XRCC4. Our model assumes that the transition from the first to second-step depends on DSB complexity, with a much slower-rate for complex DSB. The model faithfully reproduced several experimental data sets, including DSB rejoining as measured by pulsed-field electrophoresis (PFGE), quantification of the induction of gamma-H2AX foci, and live cell imaging of the induction of Ku(sub 70/80). Predictions are made for the behaviors of NHEJ components at low doses and dose-rates, where a steady-state is found at dose-rates of 0.1 Gy/hr or lower.

  17. TOWARD END-TO-END MODELING FOR NUCLEAR EXPLOSION MONITORING: SIMULATION OF UNDERGROUND NUCLEAR EXPLOSIONS AND EARTHQUAKES USING HYDRODYNAMIC AND ANELASTIC SIMULATIONS, HIGH-PERFORMANCE COMPUTING AND THREE-DIMENSIONAL EARTH MODELS

    Energy Technology Data Exchange (ETDEWEB)

    Rodgers, A; Vorobiev, O; Petersson, A; Sjogreen, B

    2009-07-06

    This paper describes new research being performed to improve understanding of seismic waves generated by underground nuclear explosions (UNE) by using full waveform simulation, high-performance computing and three-dimensional (3D) earth models. The goal of this effort is to develop an end-to-end modeling capability to cover the range of wave propagation required for nuclear explosion monitoring (NEM) from the buried nuclear device to the seismic sensor. The goal of this work is to improve understanding of the physical basis and prediction capabilities of seismic observables for NEM including source and path-propagation effects. We are pursuing research along three main thrusts. Firstly, we are modeling the non-linear hydrodynamic response of geologic materials to underground explosions in order to better understand how source emplacement conditions impact the seismic waves that emerge from the source region and are ultimately observed hundreds or thousands of kilometers away. Empirical evidence shows that the amplitudes and frequency content of seismic waves at all distances are strongly impacted by the physical properties of the source region (e.g. density, strength, porosity). To model the near-source shock-wave motions of an UNE, we use GEODYN, an Eulerian Godunov (finite volume) code incorporating thermodynamically consistent non-linear constitutive relations, including cavity formation, yielding, porous compaction, tensile failure, bulking and damage. In order to propagate motions to seismic distances we are developing a one-way coupling method to pass motions to WPP (a Cartesian anelastic finite difference code). Preliminary investigations of UNE's in canonical materials (granite, tuff and alluvium) confirm that emplacement conditions have a strong effect on seismic amplitudes and the generation of shear waves. Specifically, we find that motions from an explosion in high-strength, low-porosity granite have high compressional wave amplitudes and weak

  18. Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies

    NARCIS (Netherlands)

    van der Net, Jeroen B.; Janssens, A. Cecile J. W.; Eijkemans, Marinus J. C.; Kastelein, John J. P.; Sijbrands, Eric J. G.; Steyerberg, Ewout W.

    2008-01-01

    Cross-sectional genetic association studies can be analyzed using Cox proportional hazards models with age as time scale, if age at onset of disease is known for the cases and age at data collection is known for the controls. We assessed to what degree and under what conditions Cox proportional

  19. Analytical Modeling for the Bending Resonant Frequency of Multilayered Microresonators with Variable Cross-Section

    Directory of Open Access Journals (Sweden)

    Jian Lu

    2011-08-01

    Full Text Available Multilayered microresonators commonly use sensitive coating or piezoelectric layers for detection of mass and gas. Most of these microresonators have a variable cross-section that complicates the prediction of their fundamental resonant frequency (generally of the bending mode through conventional analytical models. In this paper, we present an analytical model to estimate the first resonant frequency and deflection curve of single-clamped multilayered microresonators with variable cross-section. The analytical model is obtained using the Rayleigh and Macaulay methods, as well as the Euler-Bernoulli beam theory. Our model is applied to two multilayered microresonators with piezoelectric excitation reported in the literature. Both microresonators are composed by layers of seven different materials. The results of our analytical model agree very well with those obtained from finite element models (FEMs and experimental data. Our analytical model can be used to determine the suitable dimensions of the microresonator’s layers in order to obtain a microresonator that operates at a resonant frequency necessary for a particular application.

  20. Influence of the worn tool affected by built-up edge (BUE) on micro end-milling process performance: A 3D finite element modeling investigation

    DEFF Research Database (Denmark)

    Davoudinejad, Ali; Tosello, Guido; Annoni, Massimiliano

    2017-01-01

    for the micro end-milling process of Aluminum material (Al6082-T6). 3D FEM simulations are carried out in full slot micro end-milling and contour up milling. The model first implements the actual tool geometry and then the effect of typical built-up edge (BUE) on the milling tool. The influence of BUE...

  1. Open-ended formulation of self-consistent field response theory with the polarizable continuum model for solvation.

    Science.gov (United States)

    Di Remigio, Roberto; Beerepoot, Maarten T P; Cornaton, Yann; Ringholm, Magnus; Steindal, Arnfinn Hykkerud; Ruud, Kenneth; Frediani, Luca

    2016-12-21

    The study of high-order absorption properties of molecules is a field of growing importance. Quantum-chemical studies can help design chromophores with desirable characteristics. Given that most experiments are performed in solution, it is important to devise a cost-effective strategy to include solvation effects in quantum-chemical studies of these properties. We here present an open-ended formulation of self-consistent field (SCF) response theory for a molecular solute coupled to a polarizable continuum model (PCM) description of the solvent. Our formulation relies on the open-ended, density matrix-based quasienergy formulation of SCF response theory of Thorvaldsen, et al., [J. Chem. Phys., 2008, 129, 214108] and the variational formulation of the PCM, as presented by Lipparini et al., [J. Chem. Phys., 2010, 133, 014106]. Within the PCM approach to solvation, the mutual solute-solvent polarization is represented by means of an apparent surface charge (ASC) spread over the molecular cavity defining the solute-solvent boundary. In the variational formulation, the ASC is an independent, variational degree of freedom. This allows us to formulate response theory for molecular solutes in the fixed-cavity approximation up to arbitrary order and with arbitrary perturbation operators. For electric dipole perturbations, pole and residue analyses of the response functions naturally lead to the identification of excitation energies and transition moments. We document the implementation of this approach in the Dalton program package using a recently developed open-ended response code and the PCMSolver libraries and present results for one-, two-, three-, four- and five-photon absorption processes of three small molecules in solution.

  2. Turkish students' perceptions of professionalism at the beginning and at the end of medical education: a cross-sectional qualitative study.

    Science.gov (United States)

    Kavas, Mustafa Volkan; Demirören, Meral; Koşan, Ayşen Melek Aytuğ; Karahan, Süleyman Tuna; Yalim, Neyyire Yasemin

    2015-01-01

    Medical students' perceptions of professionalism might reflect the impact of the current educational processes on their professional identity development. This study focuses on Ankara University Faculty of Medicine students' perceptions of 'good doctor' along with the factors effective on the formation of these perceptions. Six focus groups with 59 medical students from Grade-1 and Grade-6 were held. The transcripts of discussions were analyzed thematically. Results regarding 'being a good physician' mostly mirrored the findings of previous studies framing the medical professionalism concept. The thematic pattern of the discussions on the relation between professional development and medical education suggests that students suffer from a gradual erosion of perception during medical education. That the education cannot either change the person for the better or might downgrade the person instead of improving her/him were shared by participants from both grades. Students consider clinical practice and role models two main variables determining the person's qualification as a professional. The formal and hidden programs determine the quality and efficacy of the professional education together. Attempts to restructure medical education must recognize the reciprocal dynamics between these two components and, thus, should carefully work out the practical aspect of the educational processes.

  3. Covariance matrices for nuclear cross sections derived from nuclear model calculations

    International Nuclear Information System (INIS)

    Smith, D. L.

    2005-01-01

    The growing need for covariance information to accompany the evaluated cross section data libraries utilized in contemporary nuclear applications is spurring the development of new methods to provide this information. Many of the current general purpose libraries of evaluated nuclear data used in applications are derived either almost entirely from nuclear model calculations or from nuclear model calculations benchmarked by available experimental data. Consequently, a consistent method for generating covariance information under these circumstances is required. This report discusses a new approach to producing covariance matrices for cross sections calculated using nuclear models. The present method involves establishing uncertainty information for the underlying parameters of nuclear models used in the calculations and then propagating these uncertainties through to the derived cross sections and related nuclear quantities by means of a Monte Carlo technique rather than the more conventional matrix error propagation approach used in some alternative methods. The formalism to be used in such analyses is discussed in this report along with various issues and caveats that need to be considered in order to proceed with a practical implementation of the methodology

  4. Preferences for care towards the end of life when decision-making capacity may be impaired: A large scale cross-sectional survey of public attitudes in Great Britain and the United States.

    Directory of Open Access Journals (Sweden)

    Gemma Clarke

    Full Text Available There is continuing public debate about treatment preferences at the end of life, and the acceptability and legal status of treatments that sustain or end life. However, most surveys use binary yes/no measures, and little is known about preferences in neurological disease when decision-making capacity is lost, as most studies focus on cancer. This study investigates changes in public preferences for care towards the end of life, with a focus on measures to sustain or end life.Large-scale international public opinion surveys using a six-stage patient vignette, respondents chose a level of intervention for each stage as health and decision-making capacity deteriorated. Cross-sectional representative samples of the general public in Great Britain and the USA (N = 2016. Primary outcome measure: changes in respondents' preferences for care, measured on a four-point scale designed before data collection. The scale ranged from: maintaining life at all costs; to intervention with agreement; to no intervention; to measures for ending life.There were no significant differences between GB and USA. Preference for measures to sustain life at all costs peaked at short-term memory loss (30.2%, n = 610. Respondents selecting 'measures to help me die peacefully' increased from 3.9% to 37.0% as the condition deteriorated, with the largest increase occurring when decision-making capacity was lost (10.3% to 23.0%. Predictors of choosing 'measures to help me die peacefully' at any stage were: previous personal experience (OR = 1.34, p<0.010, and older age (OR = 1.09 per decade, p<0.010. Negative predictors: living with children (OR = 0.72, p<0.010 and being of "black" race/ethnicity (OR = 0.45, p<0.001.Public opinion was uniform between GB and USA, but markedly heterogeneous. Despite contemporaneous capacitous consent providing an essential legal safeguard in most jurisdictions, there was a high prevalence of preference for "measures to end my life peacefully" when

  5. Review of FD-TD numerical modeling of electromagnetic wave scattering and radar cross section

    Science.gov (United States)

    Taflove, Allen; Umashankar, Korada R.

    1989-01-01

    Applications of the finite-difference time-domain (FD-TD) method for numerical modeling of electromagnetic wave interactions with structures are reviewed, concentrating on scattering and radar cross section (RCS). A number of two- and three-dimensional examples of FD-TD modeling of scattering and penetration are provided. The objects modeled range in nature from simple geometric shapes to extremely complex aerospace and biological systems. Rigorous analytical or experimental validatons are provided for the canonical shapes, and it is shown that FD-TD predictive data for near fields and RCS are in excellent agreement with the benchmark data. It is concluded that with continuing advances in FD-TD modeling theory for target features relevant to the RCS problems and in vector and concurrent supercomputer technology, it is likely that FD-TD numerical modeling will occupy an important place in RCS technology in the 1990s and beyond.

  6. Projected rainfall and temperature changes over Malaysia at the end of the 21st century based on PRECIS modelling system

    Science.gov (United States)

    Loh, Jui Le; Tangang, Fredolin; Juneng, Liew; Hein, David; Lee, Dong-In

    2016-05-01

    This study investigates projected changes in rainfall and temperature over Malaysia by the end of the 21st century based on the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emission Scenarios (SRES) A2, A1B and B2 emission scenarios using the Providing Regional Climates for Impacts Studies (PRECIS). The PRECIS regional climate model (HadRM3P) is configured in 0.22° × 0.22° horizontal grid resolution and is forced at the lateral boundaries by the UKMO-HadAM3P and UKMOHadCM3Q0 global models. The model performance in simulating the present-day climate was assessed by comparing the modelsimulated results to the Asian Precipitation - Highly-Resolved Observational Data Integration Towards Evaluation (APHRODITE) dataset. Generally, the HadAM3P/PRECIS and HadCM3Q0/PRECIS simulated the spatio-temporal variability structure of both temperature and rainfall reasonably well, albeit with the presence of cold biases. The cold biases appear to be associated with the systematic error in the HadRM3P. The future projection of temperature indicates widespread warming over the entire country by the end of the 21st century. The projected temperature increment ranges from 2.5 to 3.9°C, 2.7 to 4.2°C and 1.7 to 3.1°C for A2, A1B and B2 scenarios, respectively. However, the projection of rainfall at the end of the 21st century indicates substantial spatio-temporal variation with a tendency for drier condition in boreal winter and spring seasons while wetter condition in summer and fall seasons. During the months of December to May, ~20-40% decrease of rainfall is projected over Peninsular Malaysia and Borneo, particularly for the A2 and B2 emission scenarios. During the summer months, rainfall is projected to increase by ~20-40% across most regions in Malaysia, especially for A2 and A1B scenarios. The spatio-temporal variations in the projected rainfall can be related to the changes in the weakening monsoon circulations, which in turn alter the patterns of

  7. The LXCat project: Electron scattering cross sections and swarm parameters for low temperature plasma modeling

    International Nuclear Information System (INIS)

    Pancheshnyi, S.; Biagi, S.; Bordage, M.C.; Hagelaar, G.J.M.; Morgan, W.L.; Phelps, A.V.; Pitchford, L.C.

    2012-01-01

    Graphical abstract: LXCat is an open-access website containing data needed for low temperature plasma modeling as well as on-line tools useful for their manipulation. Highlights: ► LXCat: an open-access website with data for low temperature plasma modeling. ► Contains compilations of electron scattering cross sections and transport data. ► Data from different contributors for many neutral, ground-state species. ► On-line tools for browsing, plotting, up/downloading data. ► On-line Boltzmann solver for calculating electron swarm parameters. - Abstract: LXCat is a dynamic, open-access, website for collecting, displaying, and downloading ELECtron SCATtering cross sections and swarm parameters (mobility, diffusion coefficient, reaction rates, etc.) required for modeling low temperature, non-equilibrium plasmas. Contributors set up individual databases, and the available databases, indicated by the contributor’s chosen title, include mainly complete sets of electron-neutral scattering cross sections, although the option for introducing partial sets of cross sections exists. A database for measured swarm parameters is also part of LXCat, and this is a growing activity. On-line tools include options for browsing, plotting, and downloading cross section data. The electron energy distribution functions (edfs) in low temperature plasmas are in general non-Maxwellian, and LXCat provides an option for execution of an on-line Boltzmann equation solver to calculate the edf in homogeneous electric fields. Thus, the user can obtain electron transport and rate coefficients (averages over the edfs) in pure gases or gas mixtures over a range of values of the reduced electric fields strength, E/N, the ratio of the electric field strength to the neutral density, using cross sections from the available databases. New contributors are welcome and anyone wishing to create a database and upload data can request a username and password. LXCat is part of a larger, community

  8. End use technology choice in the National Energy Modeling System (NEMS): An analysis of the residential and commercial building sectors

    International Nuclear Information System (INIS)

    Wilkerson, Jordan T.; Cullenward, Danny; Davidian, Danielle; Weyant, John P.

    2013-01-01

    The National Energy Modeling System (NEMS) is arguably the most influential energy model in the United States. The U.S. Energy Information Administration uses NEMS to generate the federal government's annual long-term forecast of national energy consumption and to evaluate prospective federal energy policies. NEMS is considered such a standard tool that other models are calibrated to its forecasts, in both government and academic practice. As a result, NEMS has a significant influence over expert opinions of plausible energy futures. NEMS is a massively detailed model whose inner workings, despite its prominence, receive relatively scant critical attention. This paper analyzes how NEMS projects energy demand in the residential and commercial sectors. In particular, we focus on the role of consumers' preferences and financial constraints, investigating how consumers choose appliances and other end-use technologies. We identify conceptual issues in the approach the model takes to the same question across both sectors. Running the model with a range of consumer preferences, we estimate the extent to which this issue impacts projected consumption relative to the baseline model forecast for final energy demand in the year 2035. In the residential sector, the impact ranges from a decrease of 0.73 quads (− 6.0%) to an increase of 0.24 quads (+ 2.0%). In the commercial sector, the impact ranges from a decrease of 1.0 quads (− 9.0%) to an increase of 0.99 quads (+ 9.0%). - Highlights: • This paper examines the impact of consumer preferences on final energy in the Commercial and Residential sectors of the National Energy Modeling System (NEMS). • We describe the conceptual and empirical basis for modeling consumer technology choice in NEMS. • We offer a range of alternative parameters to show the energy demand sensitivity to technology choice. • We show there are significant potential savings available in both building sectors. • Because the model uses its own

  9. Modeling the fate and end-of-life phase of engineered nanomaterials in the Japanese construction sector.

    Science.gov (United States)

    Suzuki, Shinya; Part, Florian; Matsufuji, Yasushi; Huber-Humer, Marion

    2018-02-01

    To date construction materials that contain engineered nanomaterials (ENMs) are available at the markets, but at the same time very little is known about their environmental fate. Therefore, this study aimed at modeling the potential fate of ENMs by using the example of the Japanese construction sector and by conducting a dynamic material flow analysis. Expert interviews and national reports revealed that about 3920-4660 tons of ENMs are annually used for construction materials in Japan. Nanoscale TiO 2 , SiO 2 , Al 2 O 3 and carbon black have already been applied for decades to wall paints, road markings or concrete. The dynamic material flow model indicates that in 2016 about 95% of ENMs, which have been used since their year of market penetration, remained in buildings, whereas only 5% ended up in the Japanese waste management system or were diffusely released into the environment. Considering the current Japanese waste management system, ENMs were predicted to end up in recycled materials (40-47%) or in landfills (36-41%). It was estimated that only a small proportion was used in agriculture (5-7%, as ENM-containing sewage sludges) or was diffusely released into soils, surface waters or the atmosphere (5-19%). The results indicate that ENM release predominantly depend on their specific applications and characteristics. The model also highlights the importance of adequate collection and treatment of ENM-containing wastes. In future, similar dynamic flow models for other countries should consider, inasmuch as available, historical data on ENM production (e.g. like declaration reports that are annually published by relevant public authorities or associations), as such input data is very important regarding data reliability in order to decrease uncertainties and to continuously improve model accuracy. In addition, more environmental monitoring studies that aim at the quantification of ENM release and inadvertent transfer, particularly triggered by waste treatment

  10. Ranking and validation of spallation models for isotopic production cross sections of heavy residua

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Sushil K.; Kamys, Boguslaw [Jagiellonian University, The Marian Smoluchowski Institute of Physics, Krakow (Poland); Goldenbaum, Frank; Filges, Detlef [Forschungszentrum Juelich, Institut fuer Kernphysik, Juelich (Germany)

    2017-07-15

    The production cross sections of isotopically identified residual nuclei of spallation reactions induced by {sup 136}Xe projectiles at 500 AMeV on hydrogen target were analyzed in a two-step model. The first stage of the reaction was described by the INCL4.6 model of an intranuclear cascade of nucleon-nucleon and pion-nucleon collisions whereas the second stage was analyzed by means of four different models; ABLA07, GEM2, GEMINI++ and SMM. The quality of the data description was judged quantitatively using two statistical deviation factors; the H-factor and the M-factor. It was found that the present analysis leads to a different ranking of models as compared to that obtained from the qualitative inspection of the data reproduction. The disagreement was caused by sensitivity of the deviation factors to large statistical errors present in some of the data. A new deviation factor, the A factor, was proposed, that is not sensitive to the statistical errors of the cross sections. The quantitative ranking of models performed using the A-factor agreed well with the qualitative analysis of the data. It was concluded that using the deviation factors weighted by statistical errors may lead to erroneous conclusions in the case when the data cover a large range of values. The quality of data reproduction by the theoretical models is discussed. Some systematic deviations of the theoretical predictions from the experimental results are observed. (orig.)

  11. Angle-correlated cross sections in the framework of the continuum shell model

    International Nuclear Information System (INIS)

    Moerschel, K.P.

    1984-01-01

    In the present thesis in the framework of the continuum shell modell a concept for the treatment of angle-correlated cross sections was developed by which coincidence experiments on electron scattering on nuclei are described. For this the existing Darmstadt continuum-shell-model code had to be extended to the calculation of the correlation coefficients in which nuclear dynamics enter and which determine completely the angle-correlated cross sections. Under inclusion of the kinematics a method for the integration over the scattered electron was presented and used for the comparison with corresponding experiments. As application correlation coefficients for the proton channel in 12 C with 1 - and 2 + excitations were studied. By means of these coefficients finally cross sections for the reaction 12 C (e,p) 11 B could be calculated and compared with the experiment whereby the developed methods were proved as suitable to predict correctly both the slope and the quantity of the experimental cross sections. (orig.) [de

  12. Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy.

    Science.gov (United States)

    Dubový, Petr; Raška, Otakar; Klusáková, Ilona; Stejskal, Lubomír; Celakovský, Pavel; Haninec, Pavel

    2011-06-22

    It is difficult to repair nerve if proximal stump is unavailable or autogenous nerve grafts are insufficient for reconstructing extensive nerve damage. Therefore, alternative methods have been developed, including lateral anastomosis based on axons' ability to send out collateral sprouts into denervated nerve. The different capacity of a sensory or motor axon to send a sprout is controversial and may be controlled by cytokines and/or neurotrophic factors like ciliary neurotrophic factor (CNTF). The aim of the present study was to quantitatively assess collateral sprouts sent out by intact motor and sensory axons in the end-to-side neurorrhaphy model following intrathecal administration of CNTF in comparison with phosphate buffered saline (vehiculum) and Cerebrolysin. The distal stump of rat transected musculocutaneous nerve (MCN) was attached in an end-to-side fashion with ulnar nerve. CNTF, Cerebrolysin and vehiculum were administered intrathecally for 2 weeks, and all animals were allowed to survive for 2 months from operation. Numbers of spinal motor and dorsal root ganglia neurons were estimated following their retrograde labeling by Fluoro-Ruby and Fluoro-Emerald applied to ulnar and musculocutaneous nerve, respectively. Reinnervation of biceps brachii muscles was assessed by electromyography, behavioral test, and diameter and myelin sheath thickness of regenerated axons. Vehiculum or Cerebrolysin administration resulted in significantly higher numbers of myelinated axons regenerated into the MCN stumps compared with CNTF treatment. By contrast, the mean diameter of the myelinated axons and their myelin sheath thickness in the cases of Cerebrolysin- or CNTF-treated animals were larger than were those for rats treated with vehiculum. CNTF treatment significantly increased the percentage of motoneurons contributing to reinnervation of the MCN stumps (to 17.1%) when compared with vehiculum or Cerebrolysin treatments (at 9.9 or 9.6%, respectively). Reduced numbers

  13. Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy

    Directory of Open Access Journals (Sweden)

    Čelakovský Pavel

    2011-06-01

    Full Text Available Abstract Background It is difficult to repair nerve if proximal stump is unavailable or autogenous nerve grafts are insufficient for reconstructing extensive nerve damage. Therefore, alternative methods have been developed, including lateral anastomosis based on axons' ability to send out collateral sprouts into denervated nerve. The different capacity of a sensory or motor axon to send a sprout is controversial and may be controlled by cytokines and/or neurotrophic factors like ciliary neurotrophic factor (CNTF. The aim of the present study was to quantitatively assess collateral sprouts sent out by intact motor and sensory axons in the end-to-side neurorrhaphy model following intrathecal administration of CNTF in comparison with phosphate buffered saline (vehiculum and Cerebrolysin. The distal stump of rat transected musculocutaneous nerve (MCN was attached in an end-to-side fashion with ulnar nerve. CNTF, Cerebrolysin and vehiculum were administered intrathecally for 2 weeks, and all animals were allowed to survive for 2 months from operation. Numbers of spinal motor and dorsal root ganglia neurons were estimated following their retrograde labeling by Fluoro-Ruby and Fluoro-Emerald applied to ulnar and musculocutaneous nerve, respectively. Reinnervation of biceps brachii muscles was assessed by electromyography, behavioral test, and diameter and myelin sheath thickness of regenerated axons. Results Vehiculum or Cerebrolysin administration resulted in significantly higher numbers of myelinated axons regenerated into the MCN stumps compared with CNTF treatment. By contrast, the mean diameter of the myelinated axons and their myelin sheath thickness in the cases of Cerebrolysin- or CNTF-treated animals were larger than were those for rats treated with vehiculum. CNTF treatment significantly increased the percentage of motoneurons contributing to reinnervation of the MCN stumps (to 17.1% when compared with vehiculum or Cerebrolysin treatments (at

  14. Analysis of Computational Fluid Dynamics and Particle Image Velocimetry Models of Distal-End Side-to-Side and End-to-Side Anastomoses for Coronary Artery Bypass Grafting in a Pulsatile Flow.

    Science.gov (United States)

    Shintani, Yoshiko; Iino, Kenji; Yamamoto, Yoshitaka; Kato, Hiroki; Takemura, Hirofumi; Kiwata, Takahiro

    2017-12-25

    Intimal hyperplasia (IH) is a major cause of graft failure. Hemodynamic factors such as stagnation and disturbed blood flow are involved in IH formation. The aim of this study is to perform a comparative analysis of distal-end side-to-side (deSTS) and end-to-side (ETS) anastomoses using computational fluid dynamics (CFD) after validating the results via particle image velocimetry (PIV).Methods and Results:We investigated the characteristics of our target flow fields using CFD under steady and pulsatile flows. CFD via PIV under steady flow in a 10-times-actual-size model was validated. The CFD analysis revealed a recirculation zone in the heel region in the deSTS and ETS anastomoses and at the distal end of the graft, and just distal to the toe of the host artery in the deSTS anastomoses. The recirculation zone sizes changed with the phase shift. We found regions of low wall shear stress and high oscillating shear index in the same areas. The PIV and CFD results were similar. It was demonstrated that the hemodynamic characteristics of CFD and PIV is the difference between the deSTS and ETS anastomoses; that is, the deSTS flow peripheral to the distal end of the graft, at the distal end and just distal to the toe of the host artery is involved in the IH formation.

  15. Cultural competence in end-of-life care: terms, definitions, and conceptual models from the British literature.

    Science.gov (United States)

    Evans, Natalie; Meñaca, Arantza; Koffman, Jonathan; Harding, Richard; Higginson, Irene J; Pool, Robert; Gysels, Marjolein

    2012-07-01

    Cultural competency is increasingly recommended in policy and practice to improve end-of-life (EoL) care for minority ethnic groups in multicultural societies. It is imperative to critically analyze this approach to understand its underlying concepts. Our aim was to appraise cultural competency approaches described in the British literature on EoL care and minority ethnic groups. This is a critical review. Articles on cultural competency were identified from a systematic review of the literature on minority ethnic groups and EoL care in the United Kingdom. Terms, definitions, and conceptual models of cultural competency approaches were identified and situated according to purpose, components, and origin. Content analysis of definitions and models was carried out to identify key components. One-hundred thirteen articles on minority ethnic groups and EoL care in the United Kingdom were identified. Over half (n=60) contained a term, definition, or model for cultural competency. In all, 17 terms, 17 definitions, and 8 models were identified. The most frequently used term was "culturally sensitive," though "cultural competence" was defined more often. Definitions contained one or more of the components: "cognitive," "implementation," or "outcome." Models were categorized for teaching or use in patient assessment. Approaches were predominantly of American origin. The variety of terms, definitions, and models underpinning cultural competency approaches demonstrates a lack of conceptual clarity, and potentially complicates implementation. Further research is needed to compare the use of cultural competency approaches in diverse cultures and settings, and to assess the impact of such approaches on patient outcomes.

  16. Trends in Modelling, Simulation and Design of Water Hydraulic Systems – Motion Control and Open-Ended Solutions

    DEFF Research Database (Denmark)

    Conrad, Finn

    2006-01-01

    is that the components operate with pure water from the tap without additives of any kind. Hence water hydraulics takes the benefit of pure water as fluid being environmentally friendly, easy to clean sanitary design, non-toxic, non-flammable, inexpensive, readily available and easily disposable. The low-pressure tap......, dedicated pumps and accessories running with sea-water as fluid are available. A unique solution is to use reverse osmosis to generate drinking water from sea-water, and furthermore for several off-shore applications. Furthermore, tap water hydraulic components of the Nessie® family and examples of measured......The paper presents and discusses a R&D-view on trends in development and best practise in modelling, simulation and design of both low-pressure and high-pressure tap water hydraulic components and systems for motion control as well as open-ended solutions various industrial applications. The focus...

  17. End-user satisfaction analysis on library management system unnes using technology acceptance model towards national standard of integrated library

    Science.gov (United States)

    Hardyanto, W.; Purwinarko, A.; Adhi, M. A.

    2018-03-01

    The library which is the gate of the University should be supported by the existence of an adequate information system, to provide excellent service and optimal to every user. Library management system that has been in existence since 2009 needs to be re-evaluated so that the system can meet the needs of both operator and Unnes user in particular, and users from outside Unnes in general. This study aims to evaluate and improve the existing library management system to produce a system that is accountable and able to meet the needs of end users, as well as produce a library management system that is integrated Unnes. Research is directed to produce evaluation report with Technology Acceptance Model (TAM) approach and library management system integrated with the national standard.

  18. Salinosporamides A and B Inhibit Proteasome Activity and Delay the Degradation of N-end Rule Model Substrates

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Seungkyun; Bang, Daein; Choi, Wonhoon; Lee, Minjae [Kyung Hee Univ., Yongin (Korea, Republic of); Kim, Seonghwan; Oh, Dongchan [Seoul National Univ., Seoul (Korea, Republic of)

    2013-05-15

    The proteasome, which is highly evolutionarily conserved, is responsible for the degradation of most short-lived proteins in cells. Small-molecule inhibitors targeting the proteasome's degradative activity have been extensively developed as lead compounds for various human diseases. An exemplified molecule is bortezomib, which was approved by FDA in 2003 for the treatment of multiple myeloma. Here, using transiently and stably expressed N-end rule model substrates in mammalian cells, we evaluated and identified that salinosporamide A and salinosporamide B effectively inhibited the proteasomal degradation. Considering that a variety of proteasome substrates are implicated in the pathogenesis of many diseases, they have the potential to be clinically applicable as therapeutic agents.

  19. A new modelling of the multigroup scattering cross section in deterministic codes for neutron transport

    International Nuclear Information System (INIS)

    Calloo, A.A.

    2012-01-01

    In reactor physics, calculation schemes with deterministic codes are validated with respect to a reference Monte Carlo code. The remaining biases are attributed to the approximations and models induced by the multigroup theory (self-shielding models and expansion of the scattering law using Legendre polynomials) to represent physical phenomena (resonant absorption and scattering anisotropy respectively). This work focuses on the relevance of a polynomial expansion to model the scattering law. Since the outset of reactor physics, the latter has been expanded on a truncated Legendre polynomial basis. However, the transfer cross sections are highly anisotropic, with non-zero values for a very small range of the cosine of the scattering angle. Besides, the finer the energy mesh and the lighter the scattering nucleus, the more exacerbated is the peaked shape of this cross section. As such, the Legendre expansion is less suited to represent the scattering law. Furthermore, this model induces negative values which are non-physical. In this work, various scattering laws are briefly described and the limitations of the existing model are pointed out. Hence, piecewise-constant functions have been used to represent the multigroup scattering cross section. This representation requires a different model for the diffusion source. The discrete ordinates method which is widely employed to solve the transport equation has been adapted. Thus, the finite volume method for angular discretization has been developed and implemented in Paris environment which hosts the S n solver, Snatch. The angular finite volume method has been compared to the collocation method with Legendre moments to ensure its proper performance. Moreover, unlike the latter, this method is adapted for both the Legendre moments and the piecewise-constant functions representations of the scattering cross section. This hybrid-source method has been validated for different cases: fuel cell in infinite lattice

  20. Aquelarre. A computer code for fast neutron cross sections from the statistical model

    International Nuclear Information System (INIS)

    Guasp, J.

    1974-01-01

    A Fortran V computer code for Univac 1108/6 using the partial statistical (or compound nucleus) model is described. The code calculates fast neutron cross sections for the (n, n'), (n, p), (n, d) and (n, α reactions and the angular distributions and Legendre moments.for the (n, n) and (n, n') processes in heavy and intermediate spherical nuclei. A local Optical Model with spin-orbit interaction for each level is employed, allowing for the width fluctuation and Moldauer corrections, as well as the inclusion of discrete and continuous levels. (Author) 67 refs

  1. Electron-Impact Excitation Cross Sections for Modeling Non-Equilibrium Gas

    Science.gov (United States)

    Huo, Winifred M.; Liu, Yen; Panesi, Marco; Munafo, Alessandro; Wray, Alan; Carbon, Duane F.

    2015-01-01

    In order to provide a database for modeling hypersonic entry in a partially ionized gas under non-equilibrium, the electron-impact excitation cross sections of atoms have been calculated using perturbation theory. The energy levels covered in the calculation are retrieved from the level list in the HyperRad code. The downstream flow-field is determined by solving a set of continuity equations for each component. The individual structure of each energy level is included. These equations are then complemented by the Euler system of equations. Finally, the radiation field is modeled by solving the radiative transfer equation.

  2. Acoustic field of an ultrasonic cavity resonator with two open ends: Experimental measurements and lattice Boltzmann method modeling

    Science.gov (United States)

    Shan, Feng; Tu, Juan; Cheng, Jianchun; Zhang, Dong; Li, Faqi; Wang, Zhibiao

    2017-03-01

    High-intensity focused ultrasound (HIFU) has become an attractive therapeutic tool for noninvasive tumor treatment. The key component of HIFU systems is the acoustic transducer, which generates a focal region of high-intensity focused ultrasonic energy. A key determinant of safety in HIFU treatment is the size of the focal region. To achieve subwavelength focusing, we previously investigated the feasibility of an ultrasonic spherical cavity resonator (USCR) with two open ends. To further investigate the properties of the USCR, experiments and simulations were performed to comprehensively characterize the acoustic field generated. The emphasis was on the field formation process, the pressure distribution, the frequency dependence, and the acoustic nonlinearity. As a novel simulation approach, an axisymmetric isothermal multi-relaxation-time lattice Boltzmann method (MRT-LBM) model was used to numerically analyze the acoustic field. The reliability of this model was verified by comparing the results generated with those from experiments. The MRT-LBM model gave new insight into conventional acoustic numerical simulations and provided significant indications for USCR parameter optimization. The USCR demonstrated its feasibility for application in HIFU treatment or in other fields that demand high-precision focusing.

  3. Structural equation models of sexual harassment: longitudinal explorations and cross-sectional generalizations.

    Science.gov (United States)

    Glomb, T M; Munson, L J; Hulin, C L; Bergman, M E; Drasgow, F

    1999-02-01

    Sexual harassment and its corresponding outcomes develop and change over time, yet research on this issue has been limited primarily to cross-sectional data. In this article, longitudinal models of harassment were proposed and empirically evaluated via structural equations modeling using data from 217 women who responded to a computerized questionnaire in 1994 and again in 1996. Results indicate that sexual harassment influences both proximal and distal work-related variables (e.g., job satisfaction, work withdrawal, job withdrawal) and psychological outcomes (e.g., life satisfaction, psychological well-being, distress). In addition, a replication of the L. F. Fitzgerald, F. Drasgow, C.L. Hulin, M.J. Gelfand, and V.J. Magley (1997) model of harassment was supported. This research was an initial attempt to develop integrated models of the dynamic effects of sexual harassment over time.

  4. Introduction to the special section on mixture modeling in personality assessment.

    Science.gov (United States)

    Wright, Aidan G C; Hallquist, Michael N

    2014-01-01

    Latent variable models offer a conceptual and statistical framework for evaluating the underlying structure of psychological constructs, including personality and psychopathology. Complex structures that combine or compare categorical and dimensional latent variables can be accommodated using mixture modeling approaches, which provide a powerful framework for testing nuanced theories about psychological structure. This special series includes introductory primers on cross-sectional and longitudinal mixture modeling, in addition to empirical examples applying these techniques to real-world data collected in clinical settings. This group of articles is designed to introduce personality assessment scientists and practitioners to a general latent variable framework that we hope will stimulate new research and application of mixture models to the assessment of personality and its pathology.

  5. Model Test Research on the End Bearing Behavior of the Large-Diameter Cast-in-Place Concrete Pile for Jointed Rock Mass

    Directory of Open Access Journals (Sweden)

    Jingwei Cai

    2016-01-01

    Full Text Available For large-diameter, cast-in-place concrete piles, the end bearing capacity of a single pile is affected by discontinuous surfaces that exist in natural rock masses when the bearing layer of the pile end is located in the rock layer. In order to study the influence of the jointed dip angle on the bearing characteristics of the pile end, the discrete element models are adopted to simulate the mechanical characteristics of the jointed rock masses, and the model tests of the failure mode of the jointed rock masses were also designed. The results of the numerical calculations and modeling tests show that the joints, which have a filtering effect on the internal stress of the bedrock located at the pile end, change the load transferring paths. And the failure mode of the jointed rock foundation also changes as jointed dip angle changes. The rock located at the pile end generally presents a wedge failure mode. In addition, the Q-S curves obtained by model tests show that the ultimate end bearing capacity of a single pile is influenced by the jointed dip angle. The above results provide an important theoretical basis for how to correctly calculate end resistance for a cast-in-place concrete pile.

  6. Thermal-hydraulic feedback model to calculate the neutronic cross-section in PWR reactions

    International Nuclear Information System (INIS)

    Santiago, Daniela Maiolino Norberto

    2011-01-01

    In neutronic codes,it is important to have a thermal-hydraulic feedback module. This module calculates the thermal-hydraulic feedback of the fuel, that feeds the neutronic cross sections. In the neutronic co de developed at PEN / COPPE / UFRJ, the fuel temperature is obtained through an empirical model. This work presents a physical model to calculate this temperature. We used the finite volume technique of discretized the equation of temperature distribution, while calculation the moderator coefficient of heat transfer, was carried out using the ASME table, and using some of their routines to our program. The model allows one to calculate an average radial temperature per node, since the thermal-hydraulic feedback must follow the conditions imposed by the neutronic code. The results were compared with to the empirical model. Our results show that for the fuel elements near periphery, the empirical model overestimates the temperature in the fuel, as compared to our model, which may indicate that the physical model is more appropriate to calculate the thermal-hydraulic feedback temperatures. The proposed model was validated by the neutronic simulator developed in the PEN / COPPE / UFRJ for analysis of PWR reactors. (author)

  7. NPP Information Model as an Innovative Approach to End-to-End Lifecycle Management of the NPP and Nuclear Knowledge Management Proven in Russia

    International Nuclear Information System (INIS)

    Tikhonovsky, V.; Kanischev, A.; Kononov, V.; Salnikov, N.; Shkarin, A.; Dorobin, D.

    2016-01-01

    Full text: Managing engineering data for an industrial facility, including integration and maintenance of all engineering and technical data, ensuring fast and convenient access to that information and its analysis, proves to be necessary in order to perform the following tasks: 1) to increase economic efficiency of the plant during its lifecycle, including the decommissioning stage; 2) to ensure strict adherence to industrial safety requirements, radiation safety requirements (in case of nuclear facilities) and environmental safety requirements during operation (including refurbishment and restoration projects) and decommissioning. While performing tasks 1) and 2), one faces a range of challenges: 1. A huge amount of information describing the plant configuration. 2. Complexity of engineering procedures, step-by-step commissioning and significant geographical distribution of industrial infrastructure. 3. High importance of plant refurbishment projects. 4. The need to ensure comprehensive knowledge transfer between different generations of operational personnel and, which is especially important for the nuclear energy industry, between the commissioning personnel generations. NPP information model is an innovative method of NPP knowledge management throughout the whole plant lifecycle. It is an integrated database with all NPP technical engineering information (design, construction, operation, diagnosing, maintenance, refurbishment). (author

  8. Sediment transport processes in the Pearl River Estuary as revealed by grain-size end-member modeling and sediment trend analysis

    Science.gov (United States)

    Li, Tao; Li, Tuan-Jie

    2018-04-01

    The analysis of grain-size distribution enables us to decipher sediment transport processes and understand the causal relations between dynamic processes and grain-size distributions. In the present study, grain sizes were measured from surface sediments collected in the Pearl River Estuary and its adjacent coastal areas. End-member modeling analysis attempts to unmix the grain sizes into geologically meaningful populations. Six grain-size end-members were identified. Their dominant modes are 0 Φ, 1.5 Φ, 2.75 Φ, 4.5 Φ, 7 Φ, and 8 Φ, corresponding to coarse sand, medium sand, fine sand, very coarse silt, silt, and clay, respectively. The spatial distributions of the six end-members are influenced by sediment transport and depositional processes. The two coarsest end-members (coarse sand and medium sand) may reflect relict sediments deposited during the last glacial period. The fine sand end-member would be difficult to transport under fair weather conditions, and likely indicates storm deposits. The three remaining fine-grained end-members (very coarse silt, silt, and clay) are recognized as suspended particles transported by saltwater intrusion via the flood tidal current, the Guangdong Coastal Current, and riverine outflow. The grain-size trend analysis shows distinct transport patterns for the three fine-grained end-members. The landward transport of the very coarse silt end-member occurs in the eastern part of the estuary, the seaward transport of the silt end-member occurs in the western part, and the east-west transport of the clay end-member occurs in the coastal areas. The results show that grain-size end-member modeling analysis in combination with sediment trend analysis help to better understand sediment transport patterns and the associated transport mechanisms.

  9. Sediment transport processes in the Pearl River Estuary as revealed by grain-size end-member modeling and sediment trend analysis

    Science.gov (United States)

    Li, Tao; Li, Tuan-Jie

    2017-07-01

    The analysis of grain-size distribution enables us to decipher sediment transport processes and understand the causal relations between dynamic processes and grain-size distributions. In the present study, grain sizes were measured from surface sediments collected in the Pearl River Estuary and its adjacent coastal areas. End-member modeling analysis attempts to unmix the grain sizes into geologically meaningful populations. Six grain-size end-members were identified. Their dominant modes are 0 Φ, 1.5 Φ, 2.75 Φ, 4.5 Φ, 7 Φ, and 8 Φ, corresponding to coarse sand, medium sand, fine sand, very coarse silt, silt, and clay, respectively. The spatial distributions of the six end-members are influenced by sediment transport and depositional processes. The two coarsest end-members (coarse sand and medium sand) may reflect relict sediments deposited during the last glacial period. The fine sand end-member would be difficult to transport under fair weather conditions, and likely indicates storm deposits. The three remaining fine-grained end-members (very coarse silt, silt, and clay) are recognized as suspended particles transported by saltwater intrusion via the flood tidal current, the Guangdong Coastal Current, and riverine outflow. The grain-size trend analysis shows distinct transport patterns for the three fine-grained end-members. The landward transport of the very coarse silt end-member occurs in the eastern part of the estuary, the seaward transport of the silt end-member occurs in the western part, and the east-west transport of the clay end-member occurs in the coastal areas. The results show that grain-size end-member modeling analysis in combination with sediment trend analysis help to better understand sediment transport patterns and the associated transport mechanisms.

  10. Cross-section model for cold neutron scattering in solid and liquid methane

    CERN Document Server

    Morishima, N

    2002-01-01

    Incoherent neutron scattering cross-sections for solid CH sub 4 in the temperature range of 20.4-90.7 K and liquid CH sub 4 at temperatures between 90.7 and 111.7 K are evaluated. A space-time correlation approach is used to describe a double-differential scattering cross-section which is basically expressed by a generalized frequency distribution. The cross-section model includes molecular translations and rotations as well as intramolecular vibrations. The former are concerned with very short-time free-gas like translation, short-lived vibration and long-time diffusion (only in liquid state). The latter consists of short-time free rotation and long-time isotropic rotational diffusion. Numerical calculations on double-differential and total cross-sections are carried out for incident neutron energies covered 0.1 mu eV to 10 eV. Good agreement with experimental results at many different temperatures is found.

  11. Edge Detection on Images of Pseudoimpedance Section Supported by Context and Adaptive Transformation Model Images

    Directory of Open Access Journals (Sweden)

    Kawalec-Latała Ewa

    2014-03-01

    Full Text Available Most of underground hydrocarbon storage are located in depleted natural gas reservoirs. Seismic survey is the most economical source of detailed subsurface information. The inversion of seismic section for obtaining pseudoacoustic impedance section gives the possibility to extract detailed subsurface information. The seismic wavelet parameters and noise briefly influence the resolution. Low signal parameters, especially long signal duration time and the presence of noise decrease pseudoimpedance resolution. Drawing out from measurement or modelled seismic data approximation of distribution of acoustic pseuoimpedance leads us to visualisation and images useful to stratum homogeneity identification goal. In this paper, the improvement of geologic section image resolution by use of minimum entropy deconvolution method before inversion is applied. The author proposes context and adaptive transformation of images and edge detection methods as a way to increase the effectiveness of correct interpretation of simulated images. In the paper, the edge detection algorithms using Sobel, Prewitt, Robert, Canny operators as well as Laplacian of Gaussian method are emphasised. Wiener filtering of image transformation improving rock section structure interpretation pseudoimpedance matrix on proper acoustic pseudoimpedance value, corresponding to selected geologic stratum. The goal of the study is to develop applications of image transformation tools to inhomogeneity detection in salt deposits.

  12. Fault-related-folding structure and reflection seismic sections. Construction of earth model using balanced cross section; Danso ga kaizaisuru shukyoku kozo no keitai to jishin tansa danmen. 1. Balanced cross section wo mochiita chika model no kochiku

    Energy Technology Data Exchange (ETDEWEB)

    Matsuoka, T.; Tamagawa, T. [Japan Petroleum Exploration Corp., Tokyo (Japan); Tsukui, R. [Japan National Oil Corp., Tokyo (Japan). Technology Research Center

    1997-05-27

    Pre-stacking depth migration treatment is studied for the estimation of the fold configuration from seismic survey cross sections. The estimation of a velocity structure is necessary for the execution of such treatment, and the utilization of structural-geological knowledge is required for its interpretation. The concept of balanced cross section in relation to the fault-bend fold constructs a stratum structure model under conditions that the deformation during fold and fault formation is a planar strain, that there is no change in volume due to deformation, and that a fold is a parallel fold. In addition to the above geometric and kinetic approach, there is another fold formation process simulation model using a Newtonian fluid for study from the viewpoint of dynamics. This simulation stands on the presumption that the boundary contains a ramp that had been in presence before fold formation and that an incompressible viscous matter is mounted on the top surface. The viscous matter flows and deforms for the formation of an anticline on the ramp. Such enables the reproduction of a fault-bend fold formation process, and helpful discussion may be furthered on the dynamic aspect of this simulation. 5 refs., 4 figs.

  13. Negative emotionality across diagnostic models: RDoC, DSM-5 Section III, and FFM.

    Science.gov (United States)

    Gore, Whitney L; Widiger, Thomas A

    2018-03-01

    The research domain criteria (RDoC) were established in an effort to explore underlying dimensions that cut across many existing disorders and to provide an alternative to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). One purpose of the present study was to suggest a potential alignment of RDoC negative valence with 2 other dimensional models of negative emotionality: five-factor model (FFM) neuroticism and the DSM-5 Section III negative affectivity. A second purpose of the study, though, was to compare their coverage of negative emotionality, more specifically with respect to affective instability. Participants were adult community residents (N = 90) currently in mental health treatment. Participants received self-report measures of RDoC negative valence, FFM neuroticism, and DSM-5 Section III negative affectivity, along with measures of affective instability, borderline personality disorder, and impairment. Findings suggested that RDoC negative valence is commensurate with FFM neuroticism and DSM-5 Section III negative affectivity, and it would be beneficial if it was expanded to include affective instability. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  14. Fuzzy risk explicit interval linear programming model for end-of-life vehicle recycling planning in the EU.

    Science.gov (United States)

    Simic, Vladimir

    2015-01-01

    End-of-life vehicles (ELVs) are vehicles that have reached the end of their useful lives and are no longer registered or licensed for use. The ELV recycling problem has become very serious in the last decade and more and more efforts are made in order to reduce the impact of ELVs on the environment. This paper proposes the fuzzy risk explicit interval linear programming model for ELV recycling planning in the EU. It has advantages in reflecting uncertainties presented in terms of intervals in the ELV recycling systems and fuzziness in decision makers' preferences. The formulated model has been applied to a numerical study in which different decision maker types and several ELV types under two EU ELV Directive legislative cases were examined. This study is conducted in order to examine the influences of the decision maker type, the α-cut level, the EU ELV Directive and the ELV type on decisions about vehicle hulks procuring, storing unprocessed hulks, sorting generated material fractions, allocating sorted waste flows and allocating sorted metals. Decision maker type can influence quantity of vehicle hulks kept in storages. The EU ELV Directive and decision maker type have no influence on which vehicle hulk type is kept in the storage. Vehicle hulk type, the EU ELV Directive and decision maker type do not influence the creation of metal allocation plans, since each isolated metal has its regular destination. The valid EU ELV Directive eco-efficiency quotas can be reached even when advanced thermal treatment plants are excluded from the ELV recycling process. The introduction of the stringent eco-efficiency quotas will significantly reduce the quantities of land-filled waste fractions regardless of the type of decision makers who will manage vehicle recycling system. In order to reach these stringent quotas, significant quantities of sorted waste need to be processed in advanced thermal treatment plants. Proposed model can serve as the support for the European

  15. Long term building energy demand for India: Disaggregating end use energy services in an integrated assessment modeling framework

    International Nuclear Information System (INIS)

    Chaturvedi, Vaibhav; Eom, Jiyong; Clarke, Leon E.; Shukla, Priyadarshi R.

    2014-01-01

    With increasing population, income, and urbanization, meeting the energy service demands for the building sector will be a huge challenge for Indian energy policy. Although there is broad consensus that the Indian building sector will grow and evolve over the coming century, there is little understanding of the potential nature of this evolution over the longer term. The present study uses a technologically detailed, service based building energy model nested in the long term, global, integrated assessment framework, GCAM, to produce scenarios of the evolution of the Indian buildings sector up through the end of the century. The results support the idea that as India evolves toward developed country per-capita income levels, its building sector will largely evolve to resemble those of the currently developed countries (heavy reliance on electricity both for increasing cooling loads and a range of emerging appliance and other plug loads), albeit with unique characteristics based on its climate conditions (cooling dominating heating and even more so with climate change), on fuel preferences that may linger from the present (for example, a preference for gas for cooking), and vestiges of its development path (including remnants of rural poor that use substantial quantities of traditional biomass). - Highlights: ► Building sector final energy demand in India will grow to over five times by century end. ► Space cooling and appliance services will grow substantially in the future. ► Energy service demands will be met predominantly by electricity and gas. ► Urban centers will face huge demand for floor space and building energy services. ► Carbon tax policy will have little effect on reducing building energy demands

  16. The Japanese Quail as an avian model for testing endocrine disrupting chemicals: endocrine and behavioral end points

    Science.gov (United States)

    Ottinger, M.A.; Abdelnabi, M.A.; Thompson, N.; Wu, J.; Henry, K.; Humphries, E.; Henry, P.F.P.

    2000-01-01

    Birds have extremely varied reproductive strategies. As such, the impact of endocrine disrupting chemicals (EDCs) can greatly differ across avian species. Precocial species, such as Japanese quail appear to be most sensitive to EDC effects during embryonic development, particularly sexual differentiation. A great deal is known about the ontogeny of Japanese quail (Coturnix japonica) relative to endocrine, neuro-endocrine, and behavioral components of reproduction. Therefore, this species provides an excellent model for understanding effects of EDCs on reproductive biology with exposure at specific stages of the life cycle. The purpose of these experiments was to conduct a 1- or 2- generation experiment with positive or negative control chemicals and to determine changes in selected end points. Japanese quail embryos were exposed to estradiol benzoate (EB; positive control) in a 2-generation design or to fadrozole (FAD; negative control) in a 1-generation design. Embryonic EB treatment resulted in significant reductions (p< 0.5) in hen day production (90.2 vs 54.1; control vs EB, resp.) and fertility (85.3 vs 33.4%, control vs EB, resp.). Males showed sharply reduced courtship and mating behaviors as well as increased lag time (26 vs 148 sec; control vs EB) in behavioral tests. Fadrozole exposure resulted in reduced hatchability of fertile eggs, particularly at higher doses. There were no significant effects on courtship and mating behavior of males although males showed an increased lag time in their responses, nally, a behavioral test for studying motor and fear responses in young chicks was used; chicks exposed to an estrogenic pesticide (methoxychlor) showed some deficits. In summary, the use of appropriate and reliable end points that are responsive to endocrine disruption are critical for assessment of EDCs. Supported in part by EPA grant R826134.

  17. Obtaining adjusted prevalence ratios from logistic regression models in cross-sectional studies.

    Science.gov (United States)

    Bastos, Leonardo Soares; Oliveira, Raquel de Vasconcellos Carvalhaes de; Velasque, Luciane de Souza

    2015-03-01

    In the last decades, the use of the epidemiological prevalence ratio (PR) instead of the odds ratio has been debated as a measure of association in cross-sectional studies. This article addresses the main difficulties in the use of statistical models for the calculation of PR: convergence problems, availability of tools and inappropriate assumptions. We implement the direct approach to estimate the PR from binary regression models based on two methods proposed by Wilcosky & Chambless and compare with different methods. We used three examples and compared the crude and adjusted estimate of PR, with the estimates obtained by use of log-binomial, Poisson regression and the prevalence odds ratio (POR). PRs obtained from the direct approach resulted in values close enough to those obtained by log-binomial and Poisson, while the POR overestimated the PR. The model implemented here showed the following advantages: no numerical instability; assumes adequate probability distribution and, is available through the R statistical package.

  18. Energy deposition model based on electron scattering cross section data from water molecules

    Energy Technology Data Exchange (ETDEWEB)

    Munoz, A; Oiler, J C [Centra de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT), Avenida Complutense 22, 28040 Madrid (Spain); Blanco, F [Departamento de Fisica Atomica, Molecular y Nuclear, Universidad Complutense de Madrid, Avenida Complutense s.n., 28040 Madrid (Spain); Gorfinkiel, J D [Department of Physiscs and Astronomy, The Open University, Walton Hall, Milton Keynes MK7 6AA (United Kingdom); Limao-Vieira, P [Departamento de Fisica, Universidade Nova de Lisboa, 2829-516 Caparica (Portugal); Maira-Vidal, A; Borge, M J G; Tengblad, O [Instituto de Estructura de la Materia, Consejo Superior de Investigaciones Cientificas (CSIC), Serrano 113-bis, 28006 Madrid, Spam (Spain); Huerga, C; Tellez, M [Hospital Universitario La Paz, paseo de la Castellana 261, 28046 Madrid (Spain); Garcia, G [Instituto de Matematicas y Fisica Fundamental, Consejo Superior de Investigaciones CientifIcas (CSIC), Serrano 113-bis, 28006 Madrid (Spain)], E-mail: g.garcia@imaff.cfmac.csic.es

    2008-10-01

    A complete set of electrons scattering cross sections by water molecules over a broad energy range, from the me V to the Me V ranges, is presented in this study. These data have been obtained by combining experiments and calculations and cover most relevant processes, both elastic and inelastic, which can take place in the considered energy range. A new Monte Carlo simulation programme has been developed using as input parameter these cross sectional data as well as experimental energy loss spectra. The simulation procedure has been applied to obtain electron tracks and energy deposition plots in water when irradiated by a Ru-106 plaque as those used for brachytherapy of ocular tumours. Finally, the low energy electron tracks provided by the present model have been compared with those obtained with other codes available in the literature.

  19. Improvements on burnup chain model and group cross section library in the SRAC system

    International Nuclear Information System (INIS)

    Akie, Hiroshi; Okumura, Keisuke; Takano, Hideki; Ishiguro, Yukio; Kaneko, Kunio.

    1992-01-01

    Data and functions of the cell burnup calculation of the SRAC system were revised to improve mainly the accuracy of the burnup calculation of high conversion light water reactors (HCLWRs). New burnup chain models were developed in order to treat fission products (FPs) and actinide nuclides in detail. Group cross section library, SRACLIB-JENDL2, was generated based on JENDL-2 nuclear data file. In generating this library, emphasis was placed on FPs and actinides. Also revised were the data such as the average energy release per fission for various actinides. These improved data were verified by performing the burnup analysis of PWR spent fuels. Some new functions were added to the SRAC system for the convenience to yield macroscopic cross sections used in the core burnup process. (author)

  20. PENGARUH BERPIKIR KREATIF DENGAN MODEL PROBLEM BASED LEARNING (PBL TERHADAP PRESTASI BELAJAR FISIKA SISWA DENGAN MENGGUNAKAN TES OPEN ENDED

    Directory of Open Access Journals (Sweden)

    T. I. Hartini

    2014-04-01

    pemikiran kreatif yang signifikan dengan menggunakan model PBL prestasi siswa fisika menggunakan uji terbuka berakhir. This study aims to determine whether there is influence creative thinking by using the model Problem Based Learning (PBL to the learning achievement of students with a physics test open ended. The hypothesis of this research is there influence creative thinking with the PBL model of physics achievement tests students through open ended. This study was conducted at Al-Hidayah MTs Cinangka Class VIII in the second semester of academic year 2012/2013. The method used in this research is the Pre-Experimental. With the target of the entire student population of MTs Al-Hidayah Cinangka, while the population of the class VIII student affordability. Data collection techniques using test instruments such as open ended research in narrative form. The research instrument before given to the object of research is done before the test instrument validity test, reliability test, test and test level difficulty distinguishing. Test the validity of the product moment formula obtained 17 valid questions and 3 questions that are not valid, while the reliability test with alpha formula for rhitung = 0.81> 0.361 = r table. Before the data were analyzed first tested for normality with the requirements of the test and the Lilliefors test homogeneity test using the test Bartlet. Normality test obtained Lhitung = 0.091 <0.161 = Ltabel it can be concluded that the samples are normally distributed. Calculation results obtained X2 hitung = 6.83991, and X2 tabel = 30.1 table it can be concluded in the second class X2 hitung < X2  tabel. Thus H0 is accepted and classes in a homogeneous state. Description of the results of the analysis of data obtained average values for pre-test of 49.3, while the average value of 79.2 for the post-test means there is an increase in student achievement. Whereas Hypothesis testing using t-test obtained thitung = 2.53> 1.994 = t table using a

  1. Critical ischemia time in a model of spinal cord section. A study performed on dogs

    OpenAIRE

    Bitar Alatorre, Wadih Emilio; Garcia Martinez, David; Rosales Corral, Sergio A.; Flores Soto, Mario E.; Velarde Silva, Gustavo; Portilla de Buen, Eliseo

    2006-01-01

    Vascular changes after acute spinal cord trauma are important factors that predispose quadriplegia, in most cases irreversible. Repair of the spinal blood flow helps the spinal cord recovery. The average time to arrive and perform surgery is 3 h in most cases. It is important to determine the critical ischemia time in order to offer better functional prognosis. A spinal cord section and vascular clamping of the spinal anterior artery at C5–C6 model was used to determine critical ischemia time...

  2. Measurement of photo-neutron cross sections and isomeric yield ratios in the {sup 89}Y(γ,xn){sup 89-x}Y reactions at the bremsstrahlung end-point energies of 65, 70 and 75 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Tatari, Mansoureh [Yazd Univ. (Iran, Islamic Republic of). Physics Dept.; Naik, Haladhara [Bhabha Atomic Research Centre, Mumbai (India). Radiochemistry Div.; Kim, Guinyun; Kim, Kwangsoo [Kyungpook National Univ., Daegu (Korea, Republic of). Dept. of Physics; Shin, Sung-Gyun; Cho, Moo-Hyun [Pohang Univ. of Science and Technology (Korea, Republic of). Div. of Advanced Nuclear Engineering

    2017-07-01

    The flux-weighted average cross sections of the {sup 89}Y(γ,xn; x=1-4){sup 89-x}Y reactions and the isomeric yield ratios of the {sup 87m,g}Y, {sup 86m,g}Y, and {sup 85m,g}Y radionuclides produced in these reactions with the bremsstrahlung end-point energies of 65, 70 and 75 MeV have been determined by an activation and off-line γ-ray spectrometric technique using the 100 MeV electron linac in Pohang Accelerator Laboratory, Korea. The theoretical {sup 89}Y(γ,xn; x=1-4){sup 89-x}Y reaction cross sections for mono-energetic photons have been calculated using the computer code TALYS 1.6. Then the flux-weighted theoretical values were obtained to compare with the present data. The flux-weighted experimental and theoretical {sup 89}Y(γ,xn; x=1-4){sup 89-x}Y reaction cross sections increase very fast from the threshold values to a certain bremsstrahlung energy, where the other reaction channels open up. Thereafter it remains constant a while and then slowly decreases with the increase of cross sections for other reactions. Similarly, the isomeric yield ratios of {sup 87m,g}Y, {sup 86m,g}Y and {sup 85m,g}Y in the {sup 89}Y(γ,xn; x=2-4){sup 89-x}Y reactions from the present work and literature data show an increasing trend from their respective threshold values to a certain bremsstrahlung energy. After a certain point of energy, the isomeric yield ratios increase slowly with the bremsstrahlung energy. These observations indicate the role of excitation energy and its partitioning in different reaction channels.

  3. Fault-related-folding structures and reflection seismic sections. Study by seismic modeling and balanced cross section; Danso ga kaizaisuru shukyoku kozo no keitai to jishin tansa danmen. 2. Seismic modeling oyobi balanced cross section ni yoru study

    Energy Technology Data Exchange (ETDEWEB)

    Tamagawa, T.; Matsuoka, T. [Japan Petroleum Exploration Corp., Tokyo (Japan); Tsukui, R. [Japan National Oil Corp., Tokyo (Japan). Technology Research Center

    1997-05-27

    It occasionally happens that there exists a part where reflection near the thrust is not clearly observed in a thrust zone seismic survey cross section. For the effective interpretation of such an occurrence, the use of geological structures as well as the reflected pattern is effective. When the velocity structures for a fold structure having a listric fault caused anticline (unidirectionally inclined with a backlimb, without a forelimb) and for a fault propagation fold are involved, a wrong interpretation may be made since they look alike in reflection wave pattern despite their difference in geological structure. In the concept of balanced cross section, a check is performed, when the stratum after deformation is recovered to the time of deposition, as to whether the geologic stratum area is conserved without excess or shortage. An excess or shortage occurs if there is an error in the model, and this shows that the fault surface or fold structure is not correctly reflected. Positive application of geological knowledge is required in the processing and interpreting of data from a seismic survey. 6 refs., 6 figs.

  4. Covariances for neutron cross sections calculated using a regional model based on local-model fits to experimental data

    International Nuclear Information System (INIS)

    Smith, D.L.; Guenther, P.T.

    1983-11-01

    We suggest a procedure for estimating uncertainties in neutron cross sections calculated with a nuclear model descriptive of a specific mass region. It applies standard error propagation techniques, using a model-parameter covariance matrix. Generally, available codes do not generate covariance information in conjunction with their fitting algorithms. Therefore, we resort to estimating a relative covariance matrix a posteriori from a statistical examination of the scatter of elemental parameter values about the regional representation. We numerically demonstrate our method by considering an optical-statistical model analysis of a body of total and elastic scattering data for the light fission-fragment mass region. In this example, strong uncertainty correlations emerge and they conspire to reduce estimated errors to some 50% of those obtained from a naive uncorrelated summation in quadrature. 37 references

  5. An analytical model of a curved beam with a T shaped cross section

    Science.gov (United States)

    Hull, Andrew J.; Perez, Daniel; Cox, Donald L.

    2018-03-01

    This paper derives a comprehensive analytical dynamic model of a closed circular beam that has a T shaped cross section. The new model includes in-plane and out-of-plane vibrations derived using continuous media expressions which produces results that have a valid frequency range above those available from traditional lumped parameter models. The web is modeled using two-dimensional elasticity equations for in-plane motion and the classical flexural plate equation for out-of-plane motion. The flange is modeled using two sets of Donnell shell equations: one for the left side of the flange and one for the right side of the flange. The governing differential equations are solved with unknown wave propagation coefficients multiplied by spatial domain and time domain functions which are inserted into equilibrium and continuity equations at the intersection of the web and flange and into boundary conditions at the edges of the system resulting in 24 algebraic equations. These equations are solved to yield the wave propagation coefficients and this produces a solution to the displacement field in all three dimensions. An example problem is formulated and compared to results from finite element analysis.

  6. The Gaussian Graphical Model in Cross-Sectional and Time-Series Data.

    Science.gov (United States)

    Epskamp, Sacha; Waldorp, Lourens J; Mõttus, René; Borsboom, Denny

    2018-04-16

    We discuss the Gaussian graphical model (GGM; an undirected network of partial correlation coefficients) and detail its utility as an exploratory data analysis tool. The GGM shows which variables predict one-another, allows for sparse modeling of covariance structures, and may highlight potential causal relationships between observed variables. We describe the utility in three kinds of psychological data sets: data sets in which consecutive cases are assumed independent (e.g., cross-sectional data), temporally ordered data sets (e.g., n = 1 time series), and a mixture of the 2 (e.g., n > 1 time series). In time-series analysis, the GGM can be used to model the residual structure of a vector-autoregression analysis (VAR), also termed graphical VAR. Two network models can then be obtained: a temporal network and a contemporaneous network. When analyzing data from multiple subjects, a GGM can also be formed on the covariance structure of stationary means-the between-subjects network. We discuss the interpretation of these models and propose estimation methods to obtain these networks, which we implement in the R packages graphicalVAR and mlVAR. The methods are showcased in two empirical examples, and simulation studies on these methods are included in the supplementary materials.

  7. Modeling the Interaction between Quinolinate and the Receptor for Advanced Glycation End Products (RAGE): Relevance for Early Neuropathological Processes

    Science.gov (United States)

    Serratos, Iris N.; Castellanos, Pilar; Pastor, Nina; Millán-Pacheco, César; Rembao, Daniel; Pérez-Montfort, Ruy; Cabrera, Nallely; Reyes-Espinosa, Francisco; Díaz-Garrido, Paulina; López-Macay, Ambar; Martínez-Flores, Karina; López-Reyes, Alberto; Sánchez-García, Aurora; Cuevas, Elvis; Santamaria, Abel

    2015-01-01

    The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor involved in neurodegenerative and inflammatory disorders. RAGE induces cellular signaling upon binding to a variety of ligands. Evidence suggests that RAGE up-regulation is involved in quinolinate (QUIN)-induced toxicity. We investigated the QUIN-induced toxic events associated with early noxious responses, which might be linked to signaling cascades leading to cell death. The extent of early cellular damage caused by this receptor in the rat striatum was characterized by image processing methods. To document the direct interaction between QUIN and RAGE, we determined the binding constant (Kb) of RAGE (VC1 domain) with QUIN through a fluorescence assay. We modeled possible binding sites of QUIN to the VC1 domain for both rat and human RAGE. QUIN was found to bind at multiple sites to the VC1 dimer, each leading to particular mechanistic scenarios for the signaling evoked by QUIN binding, some of which directly alter RAGE oligomerization. This work contributes to the understanding of the phenomenon of RAGE-QUIN recognition, leading to the modulation of RAGE function. PMID:25757085

  8. Eurasian Winter Storm Activity at the End of the Century: A CMIP5 Multi-model Ensemble Projection

    Science.gov (United States)

    Basu, Soumik; Zhang, Xiangdong; Wang, Zhaomin

    2018-01-01

    Extratropical cyclone activity over Eurasia has exhibited a weakening trend in the recent decade. Extratropical cyclones bring precipitation and hence supply fresh water for winter crops in the mid- and high-latitude regions of Eurasia. Any changes in extratropical cyclone activity over Eurasia in the future may have a critical impact on winter agriculture and the economies of affected communities. However, potential future changes in regional storm activity over Eurasia have not been studied in detail. Therefore, in this study, we investigate anticipated changes in extratropical storm activity by the end of the century through a detailed examination of the historical and future emission scenarios from six different models from CMIP5. A statistical analysis of different parameters of storm activity using a storm identification and tracking algorithm reveals a decrease in the number of storms over mid-latitude regions. However, intense storms with longer duration are projected over high latitude Eurasia. A further examination of the physical mechanism for these changes reveals that a decrease in the meridional temperature gradient and a weakening of the vertical wind shear over the mid-latitudes are responsible for these changes in storm activity.

  9. Offer acceptance practices and geographic variability in allocation model for end-stage liver disease at transplant.

    Science.gov (United States)

    Wey, Andrew; Pyke, Joshua; Schladt, David P; Gentry, Sommer E; Weaver, Tim; Salkowski, Nicholas; Kasiske, Bertram L; Israni, Ajay K; Snyder, Jon J

    2018-04-01

    Offer acceptance practices may cause geographic variability in allocation Model for End-Stage Liver Disease (aMELD) score at transplant and could magnify the effect of donor supply and demand on aMELD variability. To evaluate these issues, offer acceptance practices of liver transplant programs and donation service areas (DSAs) were estimated using offers of livers from donors recovered between January 1, 2016, and December 31, 2016. Offer acceptance practices were compared with liver yield, local placement of transplanted livers, donor supply and demand, and aMELD at transplant. Offer acceptance was associated with liver yield (odds ratio, 1.32; P offer acceptance (r = 0.09; P = 0.50). Additionally, the association between DSA-level donor-to-candidate ratios and aMELD at transplant did not change after adjustment for offer acceptance. The average squared difference in median aMELD at transplant across DSAs was 24.6; removing the effect of donor-to-candidate ratios reduced the average squared differences more than removing the effect of program-level offer acceptance (33% and 15% reduction, respectively). Offer acceptance practices and donor-to-candidate ratios independently contributed to geographic variability in aMELD at transplant. Thus, neither offer acceptance nor donor-to-candidate ratios can explain all of the geographic variability in aMELD at transplant. Liver Transplantation 24 478-487 2018 AASLD. © 2018 by the American Association for the Study of Liver Diseases.

  10. The gross theory model for neutrino-nucleus cross-section

    International Nuclear Information System (INIS)

    Samana, A R; Barbero, C A; Krmpotic, F; Duarte, S B; Dimarco, A J

    2008-01-01

    The nuclear gross theory, originally formulated by Takahashi and Yamada (1969 Prog. Theor. Phys. 41 1470) for the β-decay, is applied to the electronic-neutrino nucleus reactions, employing a more realistic description of the energetics of the Gamow-Teller resonances. The model parameters are gauged from the most recent experimental data, both for β - -decay and electron capture, separately for even-even, even-odd, odd-odd and odd-even nuclei. The numerical estimates for neutrino-nucleus cross-sections agree fairly well with previous evaluations done within the framework of microscopic models. The formalism presented here can be extended to the heavy nuclei mass region, where weak processes are quite relevant, which is of astrophysical interest because of its applications in supernova explosive nucleosynthesis

  11. Modelling study on production cross sections of {sup 111}In radioisotopes used in nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    Kara, Ayhan; Korkut, Turgay [Sinop Univ. (Turkey). Faculty of Engineering; Yigit, Mustafa [Aksaray Univ. (Turkey). Faculty of Science and Arts; Tel, Eyyup [Osmaniye Korkut Ata Univ. (Turkey). Faculty of Science and Arts

    2015-07-15

    Radiopharmaceuticals are radioactive drugs used for diagnosis or treatment in a tracer quantity with no pharmacological action. The production of radiopharmaceuticals is carried out in the special research centers generally using by the cyclotron systems. Indium-111 is one of the most useful radioisotopes used in nuclear medicine. In this paper, we calculated the production cross sections of {sup 111}In radioisotope via {sup 111-114}Cd(p,xn) nuclear reactions up to 60 MeV energy. In the model calculations, ALICE/ASH, TALYS 1.6 and EMPIRE 3.2 Malta nuclear reaction code systems were used. The model calculation results were compared to the experimental literature data and TENDL-2014 (TALYS-based) data.

  12. Chemical process modelling of Underground Coal Gasification (UCG) and evaluation of produced gas quality for end use

    Science.gov (United States)

    Korre, Anna; Andrianopoulos, Nondas; Durucan, Sevket

    2015-04-01

    Underground Coal Gasification (UCG) is an unconventional method for recovering energy from coal resources through in-situ thermo-chemical conversion to gas. In the core of the UCG lays the coal gasification process which involves the engineered injection of a blend of gasification agents into the coal resource and propagating its gasification. Athough UCG technology has been known for some time and considered a promising method for unconventional fossil fuel resources exploitation, there are limited modelling studies which achieve the necessary accuracy and realistic simulation of the processes involved. This paper uses the existing knowledge for surface gasifiers and investigates process designs which could be adapted to model UCG. Steady state simulations of syngas production were developed using the Advanced System for Process ENgineering (Aspen) Plus software. The Gibbs free energy minimisation method was used to simulate the different chemical reactor blocks which were combined using a FORTRAN code written. This approach facilitated the realistic simulation of the gasification process. A number of model configurations were developed to simulate different subsurface gasifier layouts considered for the exploitation of underground coal seams. The two gasifier layouts considered here are the linked vertical boreholes and the controlled retractable injection point (CRIP) methods. Different stages of the UCG process (i.e. initialisation, intermediate, end-phase) as well as the temperature level of the syngas collection point in each layout were found to be the two most decisive and distinctive parameters during the design of the optimal model configuration for each layout. Sensitivity analyses were conducted to investigate the significance of the operational parameters and the performance indicators used to evaluate the results. The operational parameters considered were the type of reagents injected (i.e. O2, N2, CO2, H2O), the ratio between the injected reagents

  13. Community Based Flood Modeling in Southern and Baja California to Meet End User Needs for Decision-Making

    Science.gov (United States)

    Sanders, B. F.

    2017-12-01

    Flooding of coastal and fluvial systems are the most significant natural hazards facing society, and damages have been escalating for decades globally and in the U.S. Almost all metropolitan areas are exposed to flood risk. The threat from river flooding is especially high in India and China, and coastal cities around the world are threatened by storm surge and rising sea levels. Several trends including rising sea levels, urbanization, deforestation, and rural-to-urban population shifts will increase flood exposure in the future. Flood impacts are escalating despite advances in hazards science and extensive effort to manage risks. The fundamental issue is not that flooding is becoming more severe, even though it is in some places, but rather that societies are become more vulnerable to flood impacts. A critical factor contributing to the escalation of flood impacts is that the most vulnerable sectors of communities are left out of processes to prepare for and respond to flooding. Furthermore, the translation of knowledge about flood hazards and vulnerabilities into actionable information for communities has not been effective. In Southern and Baja California, an interdisciplinary team of researchers has partnered with stakeholders in flood vulnerable communities to co-develop flood hazard information systems designed to meet end-user needs for decision-making. The initiative leveraged the power of advanced, fine-scale hydraulic models of flooding to craft intuitive visualizations of context-sensitive scenarios. This presentation will cover the ways by which the process of flood inundation modeling served as a focal point for knowledge development, as well as the unique visualizations that populate on-line information systems accessible here: http://floodrise.uci.edu/online-flood-hazard-viewers/

  14. Limit Theory for Panel Data Models with Cross Sectional Dependence and Sequential Exogeneity.

    Science.gov (United States)

    Kuersteiner, Guido M; Prucha, Ingmar R

    2013-06-01

    The paper derives a general Central Limit Theorem (CLT) and asymptotic distributions for sample moments related to panel data models with large n . The results allow for the data to be cross sectionally dependent, while at the same time allowing the regressors to be only sequentially rather than strictly exogenous. The setup is sufficiently general to accommodate situations where cross sectional dependence stems from spatial interactions and/or from the presence of common factors. The latter leads to the need for random norming. The limit theorem for sample moments is derived by showing that the moment conditions can be recast such that a martingale difference array central limit theorem can be applied. We prove such a central limit theorem by first extending results for stable convergence in Hall and Hedye (1980) to non-nested martingale arrays relevant for our applications. We illustrate our result by establishing a generalized estimation theory for GMM estimators of a fixed effect panel model without imposing i.i.d. or strict exogeneity conditions. We also discuss a class of Maximum Likelihood (ML) estimators that can be analyzed using our CLT.

  15. A Computer Model for the Hydraulic Analysis of Open Channel Cross Sections

    Directory of Open Access Journals (Sweden)

    W. H. Shayya

    1996-01-01

    Full Text Available Irrigation and hydraulic engineers are often faced with the difficulty of tedious trial solutions of the Manning equation to determine the various geometric elements of open channels. This paper addresses the development of a computer model for the design of the most commonly used channel-sections. The developed model is intended as an educational tool. It may be applied to the hydraulic design of trapezoidal , rectangular, triangular, parabolic, round-concered rectangular, and circular cross sections. Two procedures were utilized for the solution of the encountered implicit equations; the Newton-Raphson and the Regula-Falsi methods.  In order to initiate the solution process , these methods require one and two initial guesses, respectively. Tge result revealed that the Regula-Flasi method required more iterations to coverage to the solution compared to the Newton-Raphson method, irrespective of the nearness of the initial guess to the actual solution. The average number of iterations for the Regula-Falsi method was approximately three times that of the Newton-Raphson method.

  16. Model for neutron total cross-section at low energies for nuclear grade graphite

    International Nuclear Information System (INIS)

    Galván Josa, V.M.; Dawidowski, J.; Santisteban, J.R.; Malamud, F.; Oliveira, R.G.

    2015-01-01

    At subthermal neutron energies, polycrystalline graphite shows a large total cross-section due to small angle scattering processes. In this work, a new methodology to determine pore size distributions through the neutron transmission technique at subthermal energies is proposed and its sensitivity is compared with standard techniques. A simple model based on the form factor for spherical particles, normally used in the Small Angle Neutron Scattering technique, is employed to calculate the contribution of small angle effect to the total scattering cross-section, with the width and center of the radii distributions as free parameters in the model. Small Angle X-ray Scattering experiments were performed to compare results as a means to validate the method. The good agreement reached reveals that the neutron transmission technique is a useful tool to explore small angle scattering effects. This fact can be exploited in situations where large samples must be scanned and it is difficult to investigate them with conventional methods. It also opens the possibility to apply this method in energy-resolved neutron imaging. Also, since subthermal neutron transmission experiments are perfectly feasible in small neutron sources, the present findings open new possibilities to the work done in such kind of facilities

  17. Expanding the role of community mobilization to accelerate progress towards ending vertical transmission of HIV in Uganda: the Networks model.

    Science.gov (United States)

    Mburu, Gitau; Iorpenda, Kate; Muwanga, Fred

    2012-07-11

    Efforts to prevent vertical transmission of HIV have gained momentum globally since the launch of the "Global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive", reflecting the growing consensus that we now have low-cost, efficacious interventions that promise to end vertical transmission of HIV. Uganda is one of the 22 focus countries in the global plan and one of the 10 countries with the highest need for prevention of vertical transmission globally. In the context of current shortfalls in the prevention of vertical HIV transmission, this paper presents the results of the Networks project, a community mobilisation model implemented by the International HIV/AIDS Alliance in Uganda, and draws out the theoretical foundations and promising community mobilization practices relevant to prevention of vertical transmission. A retrospective review of the Network project's activities, documentation and evaluation was performed. The Networks project, through community mobilisation and greater involvement of people living with HIV, reached an estimated 1.3 million people with at least one health service. By clustering 750 groups of people living with HIV into larger coalitions, the project supported existing groups to amalgamate their collective strengths and skills in outreach, referral and literacy activities; and improved reach and coverage of HIV services through strengthened linkages with healthcare facilities. Our analysis of the Networks model shows that it could contribute to the prevention of vertical transmission of HIV as a replicable and sustainable community mobilisation approach. In particular, the Networks model increased the uptake of decentralized interventions for preventing vertical transmission through community referrals; promoted male involvement through peer sensitisation; and linked communities to advocacy channels for advancing maternal health and prevention of vertical HIV transmission. BY

  18. Clinically relevant differences in the model for end-stage liver disease and model for end-stage liver disease-sodium scores determined at three university-based laboratories of the same area.

    Science.gov (United States)

    Xiol, Xavier; Gines, Pere; Castells, Lluis; Twose, Jorge; Ribalta, Alba; Fuentes-Arderiu, Xavier; Rodriguez, Santiago; Castellote, Jose; Navasa, Miquel; Deulofeu, Roser

    2009-03-01

    The Model for End-Stage Liver Disease (MELD) score is considered an objective and reliable measure of liver disease severity. However, the use of specific laboratory methodologies may introduce significant and clinically relevant variations into the score. It has been suggested that the incorporation of sodium into MELD (MELD-Na) can provide a more accurate survival prediction than MELD alone. Before implementing organ allocation based on the MELD score in an area with 3 transplant centers, we studied whether there were significant variations in MELD and MELD-Na scores determined at each center. Seventy patients on the waiting list were studied simultaneously. Blood samples for each patient were divided into 3 aliquots and were processed in the 3 laboratories in order to calculate MELD and MELD-Na scores. There were statistical differences between the 3 laboratories in the MELD and MELD-Na scores and their parameters. The MELD score was identical in the 3 laboratories for only 6 of the 70 patients, and the MELD-Na score was identical for only 9. MELD and MELD-Na scores from 2 laboratories differed by 1 point or more in 54% and 47% of cases, respectively. Our study confirms that there is major variability in the MELD score, serum sodium, and MELD-Na score. These differences are clinically relevant, and in order to guarantee equitable organ allocation based on the MELD score, similar laboratory methodologies should be implemented at all centers in the same organ procurement area. Alternatively, the possibility of setting up a central laboratory in each organ procurement area should be considered.

  19. Barium anomaly preceding K/T boundary: possible causes and implications on end Cretaceous events of K/T sections in Cauvery basin (India), Israel, NE-Mexico and Guatemala

    Science.gov (United States)

    Ramkumar, M.; Harting, M.; Stüben, D.

    2005-07-01

    Maastrichtian Danian strata of the Cauvery basin as well as selected sections of NE-Mexico, Guatemala and Israel record Ba anomalies, away from the Cretaceous/Tertiary boundary (KTB) in addition to common occurrences of geochemical and stable isotopic anomalies across the KTB. Ba anomalies were recorded in monotonous shallow marine sandstones of the Cauvery basin (south India) which contain minor amounts of Ba-orthoclase. Barium anomalies were observed also in shallow marine carbonates in sections of Israel, NE-Mexico and Guatemala. Calculation of excess Ba with reference to PAAS (Post-Archaen Average Australian Shale), comparison of coeval geochemical anomalies, depositional pattern and associated petrographic and mineralogical features of the Cauvery basin revealed that while a first Ba peak was related to detrital influx, the second Ba peak was coincident with sea level fall which in turn may have been influenced by emission of volatile hydrocarbons and resultant climatic changes. In view of intrinsic involvement of Ba in various geochemical processes and occurrence of Ba anomalies in K/T sites distributed around the world (NE-Mexico, Guatemala and Israel), it is suggested that probable causes of such widespread Ba-anomalies should be taken into consideration while analyzing end Cretaceous events. These observations support the views espoused by many workers who have stated that the K/T boundary was also accompanied by many non-catastrophic events that might have contributed to environmental stress on marine fauna, as a result of which selective multi-stage extinctions occurred.

  20. Analysis Method for Laterally Loaded Pile Groups Using an Advanced Modeling of Reinforced Concrete Sections

    Directory of Open Access Journals (Sweden)

    Stefano Stacul

    2018-02-01

    Full Text Available A Boundary Element Method (BEM approach was developed for the analysis of pile groups. The proposed method includes: the non-linear behavior of the soil by a hyperbolic modulus reduction curve; the non-linear response of reinforced concrete pile sections, also taking into account the influence of tension stiffening; the influence of suction by increasing the stiffness of shallow portions of soil and modeled using the Modified Kovacs model; pile group shadowing effect, modeled using an approach similar to that proposed in the Strain Wedge Model for pile groups analyses. The proposed BEM method saves computational effort compared to more sophisticated codes such as VERSAT-P3D, PLAXIS 3D and FLAC-3D, and provides reliable results using input data from a standard site investigation. The reliability of this method was verified by comparing results from data from full scale and centrifuge tests on single piles and pile groups. A comparison is presented between measured and computed data on a laterally loaded fixed-head pile group composed by reinforced concrete bored piles. The results of the proposed method are shown to be in good agreement with those obtained in situ.

  1. The effect of scaling physiological cross-sectional area on musculoskeletal model predictions.

    Science.gov (United States)

    Bolsterlee, Bart; Vardy, Alistair N; van der Helm, Frans C T; Veeger, H E J DirkJan

    2015-07-16

    Personalisation of model parameters is likely to improve biomechanical model predictions and could allow models to be used for subject- or patient-specific applications. This study evaluates the effect of personalising physiological cross-sectional areas (PCSA) in a large-scale musculoskeletal model of the upper extremity. Muscle volumes obtained from MRI were used to scale PCSAs of five subjects, for whom the maximum forces they could exert in six different directions on a handle held by the hand were also recorded. The effect of PCSA scaling was evaluated by calculating the lowest maximum muscle stress (σmax, a constant for human skeletal muscle) required by the model to reproduce these forces. When the original cadaver-based PCSA-values were used, strongly different between-subject σmax-values were found (σmax=106.1±39.9 N cm(-2)). A relatively simple, uniform scaling routine reduced this variation substantially (σmax=69.4±9.4 N cm(-2)) and led to similar results to when a more detailed, muscle-specific scaling routine was used (σmax=71.2±10.8 N cm(-2)). Using subject-specific PCSA values to simulate an shoulder abduction task changed muscle force predictions for the subscapularis and the pectoralis major on average by 33% and 21%, respectively, but was scaling. We conclude that individualisation of the model's strength can most easily be done by scaling PCSA with a single factor that can be derived from muscle volume data or, alternatively, from maximum force measurements. However, since PCSA scaling only marginally changed muscle and joint contact force predictions for submaximal tasks, the need for PCSA scaling remains debatable. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Multitype Events and the Analysis of Heart Failure Readmissions: Illustration of a New Modeling Approach and Comparison With Familiar Composite End Points.

    Science.gov (United States)

    Brown, Paul M; Ezekowitz, Justin A

    2017-06-01

    Heart failure-related hospital readmissions and mortality are often outcomes in clinical trials. Patients may experience multiple hospital readmissions over time with mortality acting as a dependent terminal event. Univariate composite end points are used for the analysis of readmissions. We may amend these approaches to include emergency department visits as a further outcome. An alternative multivariate modeling approach that categorizes hospital readmissions and emergency department visits as separate event types is proposed. We seek to compare the modeling approach which handles event types as separate, correlated end points against composites that amalgamate them to create a unified end point. Using a heart failure data set for illustration, a model with random effects for event types is estimated. The time-to-first event, unmatched win-ratio, and days-alive-and-out-of-hospital composites are derived for comparison. The model provides supplementary statistics such as the correlation among event types and yields considerably more power than the competing composite end points. The effect on individual outcomes is lost when they are intermingled to form a univariate composite. Simultaneously modeling different outcomes provides an alternative or supplementary analysis that may yield greater statistical power and additional insights. Improvements in software have made the multitype events model easier to implement and thus a useful, more efficient option when analyzing heart failure hospital readmissions and emergency department visits. © 2017 American Heart Association, Inc.

  3. Communication for end-of-life care planning among Korean patients with terminal cancer: A context-oriented model.

    Science.gov (United States)

    Koh, Su Jin; Kim, Shinmi; Kim, Jinshil

    2016-02-01

    In Korea, patients with terminal cancer are often caught out of the loop in end-of-life (EoL) care discussions. Healthcare professionals also have difficulty engaging in such communication in a variety of healthcare contexts. Therefore, the objective of our study was to develop a communication model for EoL care decision making compatible with the clinical environment in Korea. Using focus-group interview methodology, participants included eight doctors and five nurses who provide EoL care for terminal cancer patients in acute hospital settings or hospice care facilities in various provinces of Korea. Five themes emerged regarding EoL care discussion, which included: (1) timing, (2) responsible professionals, (3) disclosure of bad news, (4) content areas of EoL care discussion, and (5) implementing strategies for EoL care discussions. These themes were based on development of a communication algorithm for EoL discussion among patients with terminal cancer. A structural communication step for delivery of a terminal prognosis was specified at the phase of disclosure of bad news: beginning with determination of a patient's decision-making capability, followed by a patient's perception of his/her condition, a patient's wish to know, family dynamics, and a patient's and/or family's readiness for EoL discussions. The proposed context-oriented communication algorithm could provide a helpful guideline for EoL communication and, accordingly, facilitate meaningful improvements in EoL care in Korean clinical practice. The feasibility of this algorithm has not yet been determined, and its validation in a larger sample of patients with terminal cancers, using a quantitative research methodology, is a priority of research.

  4. Arcus end-to-end simulations

    Science.gov (United States)

    Wilms, Joern; Guenther, H. Moritz; Dauser, Thomas; Huenemoerder, David P.; Ptak, Andrew; Smith, Randall; Arcus Team

    2018-01-01

    We present an overview of the end-to-end simulation environment that we are implementing as part of the Arcus phase A Study. With the rcus simulator, we aim to to model the imaging, detection, and event reconstruction properties of the spectrometer. The simulator uses a Monte Carlo ray-trace approach, projecting photons onto the Arcus focal plane from the silicon pore optic mirrors and critical-angle transmission gratings. We simulate the detection and read-out of the photons in the focal plane CCDs with software originally written for the eROSITA and Athena-WFI detectors; we include all relevant detector physics, such as charge splitting, and effects of the detector read-out, such as out of time events. The output of the simulation chain is an event list that closely resembles the data expected during flight. This event list is processed using a prototype event reconstruction chain for the order separation, wavelength calibration, and effective area calibration. The output is compatible with standard X-ray astronomical analysis software.During phase A, the end-to-end simulation approach is used to demonstrate the overall performance of the mission, including a full simulation of the calibration effort. Continued development during later phases of the mission will ensure that the simulator remains a faithful representation of the true mission capabilities, and will ultimately be used as the Arcus calibration model.

  5. Diverging effects of diabetes mellitus in patients with peripheral artery disease and abdominal aortic aneurysm and the role of advanced glycation end-products: ARTERY study - protocol for a multicentre cross-sectional study.

    Science.gov (United States)

    de Vos, L C; Boersema, J; Hillebrands, J L; Schalkwijk, C G; Meerwaldt, R; Breek, J C; Smit, A J; Zeebregts, C J; Lefrandt, J D

    2017-04-11

    Diabetes mellitus is a well-defined risk factor for peripheral artery disease (PAD), but protects against the development and growth of abdominal aortic aneurysm (AAA). Diabetes mellitus is associated with arterial stiffening and peripheral arterial media sclerosis. Advanced glycation end-products (AGEs) are increased in diabetes mellitus and cardiovascular disease. AGEs are known to form cross-links between proteins and are associated with arterial stiffness. Whether AGEs contribute to the protective effects of diabetes mellitus in AAA is unknown. Therefore, the ARTERY ( A dvanced glycation end-p R oducts in patients with peripheral ar T ery dis E ase and abdominal ao R tic aneur Y sm) study is designed to evaluate the role of AGEs in the diverging effects of diabetes mellitus on AAA and PAD. This cross-sectional multicentre study will compare the amount, type and location of AGEs in the arterial wall in a total of 120 patients with AAA or PAD with and without diabetes mellitus (n=30 per subgroup). Also, local and systemic vascular parameters, including pulse wave velocity, will be measured to evaluate the association between arterial stiffness and AGEs. Finally, AGEs will be measured in serum, urine, and assessed in skin with skin autofluorescence using the AGE Reader. This study is approved by the Medical Ethics committees of University Medical Center Groningen, Martini Hospital and Medisch Spectrum Twente, the Netherlands. Study results will be disseminated through peer-reviewed journals and scientific events. trialregister.nl NTR 5363. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  6. CompSim: Cross sectional modeling of geometrical complex and inhomogeneous slender structures

    Directory of Open Access Journals (Sweden)

    Turaj Ashuri

    2017-01-01

    Full Text Available Many engineering disciplines require a fast and accurate estimate of structural properties in initial design phase for analysis and optimization studies. This paper presents an open-source computational code named CompSim to develop the structural properties of complex geometries with inhomogeneous materials. Weighted average technique is used to compute properties such as stiffness coefficients, area moment of inertia, and mass distribution. The accuracy of the code is evaluated for a multi-layer composite cross-section. As an illustrative example, the properties of the 20 MW common research wind turbine model are computed and presented. The code helps users to develop and optimize an initial structure in conceptual and preliminary design for further analysis in detailed design phase.

  7. CompSim: Cross sectional modeling of geometrical complex and inhomogeneous slender structures

    Science.gov (United States)

    Ashuri, Turaj; Zhang, Jie

    Many engineering disciplines require a fast and accurate estimate of structural properties in initial design phase for analysis and optimization studies. This paper presents an open-source computational code named CompSim to develop the structural properties of complex geometries with inhomogeneous materials. Weighted average technique is used to compute properties such as stiffness coefficients, area moment of inertia, and mass distribution. The accuracy of the code is evaluated for a multi-layer composite cross-section. As an illustrative example, the properties of the 20 MW common research wind turbine model are computed and presented. The code helps users to develop and optimize an initial structure in conceptual and preliminary design for further analysis in detailed design phase.

  8. Kidney function and mortality post-liver transplant in the Model for End-Stage Liver Disease era

    Directory of Open Access Journals (Sweden)

    Sethi A

    2011-11-01

    Full Text Available Aastha Sethi1, Michelle M Estrella1, Richard Ugarte2, Mohamed G Atta1 1Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD, USA; 2University of Maryland Medical Center, Department of Medicine, Baltimore, MD, USA Abstract: The Model for End-Stage Liver Disease (MELD score incorporates serum creatinine and was introduced to facilitate allocation of orthotopic liver transplantation (LT. The objective is to determine the impact of MELD and kidney function on all-cause mortality. Among LTs performed in a tertiary referral hospital between 1995 and 2009, 419 cases were studied. Cox proportional hazards models were constructed to estimate the hazard ratios (HR and 95% confidence intervals (CI for death. Over mean follow-ups of 8.4 and 3.1 years during the pre-MELD and MELD era, 57 and 63 deaths were observed, respectively. Those transplanted during the MELD era had a higher likelihood of hepatorenal syndrome (8% vs 2%, P < 0.01, lower kidney function (median estimated glomerular filtration rate [eGFR] 77.8 vs 92.6 mL/min/1.73 m2, P < 0.01, and more pretransplantation renal replacement therapy (RRT (5% vs 1%; P < 0.01. All-cause mortality risk was similar in the MELD vs the pre-MELD era (HR: 0.98, 95% CI: 0.58–1.65. The risk of death, however, was nearly 3-fold greater (95% CI: 1.14–6.60 among those requiring pre-transplant RRT. Similarly, eGFR < 60 mL/min/1.73 m2 post-transplant was associated with a 2.5-fold higher mortality (95% CI: 1.48–4.11. The study suggests that MELD implementation had no impact on all-cause mortality post-LT. However, the need for pre-transplant RRT and post-transplant kidney dysfunction was associated with a more than 2-fold greater risk of subsequent death. Keywords: eGFR, mortality, MELD, liver transplant

  9. Positive end-expiratory pressure improves survival in a rodent model of cardiopulmonary resuscitation using high-dose epinephrine.

    Science.gov (United States)

    McCaul, Conán; Kornecki, Alik; Engelberts, Doreen; McNamara, Patrick; Kavanagh, Brian P

    2009-10-01

    Multiple interventions have been tested in models of cardiopulmonary resuscitation (CPR) to optimize drug use, chest compressions, and ventilation. None has studied the effects of positive end-expiratory pressure (PEEP) on outcome. We hypothesized that because PEEP can reverse pulmonary atelectasis, lower pulmonary vascular resistance, and potentially improve cardiac output, its use during CPR would increase survival. Anesthetized Sprague-Dawley rats were exposed to 1 min of asphyxial cardiac arrest. Resuscitation was standardized and consisted of chest compressions, oxygen (Fio(2) 1.0), and IV epinephrine 30 microg/kg (Series 1) and 10 microg/kg (Series 2). Left ventricular function was assessed by echocardiography (Series 1), and animals were randomized to receive either 5 cm H(2)O PEEP or zero PEEP at commencement of CPR and throughout resuscitation. Survival was defined as the presence of a spontaneous circulation 60 or 120 min (Series 2) after initial resuscitation. There were no baseline differences between the groups. In Series 1, administration of 5 cm H(2)O PEEP (Fio(2) 1.0 and 0.21) was associated with improved survival compared with zero PEEP (7/9 and 6/6 vs 0/9, P CPR did not adversely affect left ventricular systolic function or arterial blood pressure. The outcome differences were not due to increased oxygenation because the rank order of survival was 5 cm H(2)O PEEP (Fio(2) 1.0) approximately 5 cm H(2)O PEEP (Fio(2) 0.21) > zero PEEP (Fio(2) 1.0), whereas the rank order of Pao(2) was 5 cm H(2)O PEEP (Fio(2) 1.0) > 5 cm H(2)O PEEP (Fio(2) 0.21) approximately zero PEEP (Fio(2) 1.0). In an additional series in which epinephrine 10 microg/kg was used (Series 2), the survival was 100% with no beneficial effects of PEEP. In asphyxial cardiac arrest in a small rodent model, continuous application of PEEP (5 cm H(2)O) during and after CPR had beneficial effects on survival that were independent of oxygenation and without adverse cardiovascular effects.

  10. A new model for analyzing nonlinear torsion behavior of concrete filled steel tube columns with rectangular section

    Science.gov (United States)

    Wang, Yuhang; Nie, Jianguo; Fan, Jiansheng

    2016-06-01

    An experimental study on concrete filled steel tube columns with rectangular section subjected to compressionflexure-torsion combined action has been carried out. The failure modes and load-deformation hysteretic relations were obtained. Based on the principles of classical material mechanics, the relations between the torsion curvature of the section and the shear strain of the fiber on the section were established. Then the strain distribution on the rectangular section of concrete filled steel tube columns subjected to torsion was analyzed. The three-dimensional refined finite element model was also built, in order to make the precision verification. The matrix forms of the relation between the torsion curvature of the section and the shear strain of the fiber on the section were derived, and introduced into the fiber beam model considering nonlinear torsion effect on the section. The comparison between test results and calculation results showed that the fiber beam model considering nonlinear torsion effect had high modeling efficiency and solution precision for predicting the torsion behavior of concrete filled steel tube columns with rectangular sections, and was suitable for analyzing the dynamic response of various structures subjected to the combined cyclic load caused by the earthquake load.

  11. A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship

    Science.gov (United States)

    2013-01-01

    Background The end-systolic pressure-volume relationship is often considered as a load-independent property of the heart and, for this reason, is widely used as an index of ventricular contractility. However, many criticisms have been expressed against this index and the underlying time-varying elastance theory: first, it does not consider the phenomena underlying contraction and second, the end-systolic pressure volume relationship has been experimentally shown to be load-dependent. Methods In place of the time-varying elastance theory, a microscopic model of sarcomere contraction is used to infer the pressure generated by the contraction of the left ventricle, considered as a spherical assembling of sarcomere units. The left ventricle model is inserted into a closed-loop model of the cardiovascular system. Finally, parameters of the modified cardiovascular system model are identified to reproduce the hemodynamics of a normal dog. Results Experiments that have proven the limitations of the time-varying elastance theory are reproduced with our model: (1) preload reductions, (2) afterload increases, (3) the same experiments with increased ventricular contractility, (4) isovolumic contractions and (5) flow-clamps. All experiments simulated with the model generate different end-systolic pressure-volume relationships, showing that this relationship is actually load-dependent. Furthermore, we show that the results of our simulations are in good agreement with experiments. Conclusions We implemented a multi-scale model of the cardiovascular system, in which ventricular contraction is described by a detailed sarcomere model. Using this model, we successfully reproduced a number of experiments that have shown the failing points of the time-varying elastance theory. In particular, the developed multi-scale model of the cardiovascular system can capture the load-dependence of the end-systolic pressure-volume relationship. PMID:23363818

  12. A systematics of optical model compound nucleus formation cross sections for neutrons, proton, deuteron, 3He and alpha particle incidents

    International Nuclear Information System (INIS)

    Murata, Toru

    2000-01-01

    Simple formulae to reproduce the optical model compound nucleus formation cross sections for neutron, proton, deuteron, triton, 3 He and alpha particles are presented for target nuclei of light to medium weight mass region. (author)

  13. Sensitivity of predictions in an effective model: Application to the chiral critical end point position in the Nambu-Jona-Lasinio model

    International Nuclear Information System (INIS)

    Biguet, Alexandre; Hansen, Hubert; Brugiere, Timothee; Costa, Pedro; Borgnat, Pierre

    2015-01-01

    The measurement of the position of the chiral critical end point (CEP) in the QCD phase diagram is under debate. While it is possible to predict its position by using effective models specifically built to reproduce some of the features of the underlying theory (QCD), the quality of the predictions (e.g., the CEP position) obtained by such effective models, depends on whether solving the model equations constitute a well- or ill-posed inverse problem. Considering these predictions as being inverse problems provides tools to evaluate if the problem is ill-conditioned, meaning that infinitesimal variations of the inputs of the model can cause comparatively large variations of the predictions. If it is ill-conditioned, it has major consequences because of finite variations that could come from experimental and/or theoretical errors. In the following, we shall apply such a reasoning on the predictions of a particular Nambu-Jona-Lasinio model within the mean field + ring approximations, with special attention to the prediction of the chiral CEP position in the (T-μ) plane. We find that the problem is ill-conditioned (i.e. very sensitive to input variations) for the T-coordinate of the CEP, whereas, it is well-posed for the μ-coordinate of the CEP. As a consequence, when the chiral condensate varies in a 10MeV range, μ CEP varies far less. As an illustration to understand how problematic this could be, we show that the main consequence when taking into account finite variation of the inputs, is that the existence of the CEP itself cannot be predicted anymore: for a deviation as low as 0.6% with respect to vacuum phenomenology (well within the estimation of the first correction to the ring approximation) the CEP may or may not exist. (orig.)

  14. Spatio-temporal Rich Model Based Video Steganalysis on Cross Sections of Motion Vector Planes.

    Science.gov (United States)

    Tasdemir, Kasim; Kurugollu, Fatih; Sezer, Sakir

    2016-05-11

    A rich model based motion vector steganalysis benefiting from both temporal and spatial correlations of motion vectors is proposed in this work. The proposed steganalysis method has a substantially superior detection accuracy than the previous methods, even the targeted ones. The improvement in detection accuracy lies in several novel approaches introduced in this work. Firstly, it is shown that there is a strong correlation, not only spatially but also temporally, among neighbouring motion vectors for longer distances. Therefore, temporal motion vector dependency along side the spatial dependency is utilized for rigorous motion vector steganalysis. Secondly, unlike the filters previously used, which were heuristically designed against a specific motion vector steganography, a diverse set of many filters which can capture aberrations introduced by various motion vector steganography methods is used. The variety and also the number of the filter kernels are substantially more than that of used in previous ones. Besides that, filters up to fifth order are employed whereas the previous methods use at most second order filters. As a result of these, the proposed system captures various decorrelations in a wide spatio-temporal range and provides a better cover model. The proposed method is tested against the most prominent motion vector steganalysis and steganography methods. To the best knowledge of the authors, the experiments section has the most comprehensive tests in motion vector steganalysis field including five stego and seven steganalysis methods. Test results show that the proposed method yields around 20% detection accuracy increase in low payloads and 5% in higher payloads.

  15. Comparison of primary care models in the prevention of cardiovascular disease - a cross sectional study

    Directory of Open Access Journals (Sweden)

    Hogg William

    2011-10-01

    Full Text Available Abstract Background Primary care providers play an important role in preventing and managing cardiovascular disease. This study compared the quality of preventive cardiovascular care delivery amongst different primary care models. Methods This is a secondary analysis of a larger randomized control trial, known as the Improved Delivery of Cardiovascular Care (IDOCC through Outreach Facilitation. Using baseline data collected through IDOCC, we conducted a cross-sectional study of 82 primary care practices from three delivery models in Eastern Ontario, Canada: 43 fee-for-service, 27 blended-capitation and 12 community health centres with salary-based physicians. Medical chart audits from 4,808 patients with or at high risk of developing cardiovascular disease were used to examine each practice's adherence to ten evidence-based processes of care for diabetes, chronic kidney disease, dyslipidemia, hypertension, weight management, and smoking cessation care. Generalized estimating equation models adjusting for age, sex, rurality, number of cardiovascular-related comorbidities, and year of data collection were used to compare guideline adherence amongst the three models. Results The percentage of patients with diabetes that received two hemoglobin A1c tests during the study year was significantly higher in community health centres (69% than in fee-for-service (45% practices (Adjusted Odds Ratio (AOR = 2.4 [95% CI 1.4-4.2], p = 0.001. Blended capitation practices had a significantly higher percentage of patients who had their waistlines monitored than in fee-for-service practices (19% vs. 5%, AOR = 3.7 [1.8-7.8], p = 0.0006, and who were recommended a smoking cessation drug when compared to community health centres (33% vs. 16%, AOR = 2.4 [1.3-4.6], p = 0.007. Overall, quality of diabetes care was higher in community health centres, while smoking cessation care and weight management was higher in the blended-capitation models. Fee-for-service practices

  16. Comparison of primary care models in the prevention of cardiovascular disease - a cross sectional study.

    Science.gov (United States)

    Liddy, Clare; Singh, Jatinderpreet; Hogg, William; Dahrouge, Simone; Taljaard, Monica

    2011-10-18

    Primary care providers play an important role in preventing and managing cardiovascular disease. This study compared the quality of preventive cardiovascular care delivery amongst different primary care models. This is a secondary analysis of a larger randomized control trial, known as the Improved Delivery of Cardiovascular Care (IDOCC) through Outreach Facilitation. Using baseline data collected through IDOCC, we conducted a cross-sectional study of 82 primary care practices from three delivery models in Eastern Ontario, Canada: 43 fee-for-service, 27 blended-capitation and 12 community health centres with salary-based physicians. Medical chart audits from 4,808 patients with or at high risk of developing cardiovascular disease were used to examine each practice's adherence to ten evidence-based processes of care for diabetes, chronic kidney disease, dyslipidemia, hypertension, weight management, and smoking cessation care. Generalized estimating equation models adjusting for age, sex, rurality, number of cardiovascular-related comorbidities, and year of data collection were used to compare guideline adherence amongst the three models. The percentage of patients with diabetes that received two hemoglobin A1c tests during the study year was significantly higher in community health centres (69%) than in fee-for-service (45%) practices (Adjusted Odds Ratio (AOR) = 2.4 [95% CI 1.4-4.2], p = 0.001). Blended capitation practices had a significantly higher percentage of patients who had their waistlines monitored than in fee-for-service practices (19% vs. 5%, AOR = 3.7 [1.8-7.8], p = 0.0006), and who were recommended a smoking cessation drug when compared to community health centres (33% vs. 16%, AOR = 2.4 [1.3-4.6], p = 0.007). Overall, quality of diabetes care was higher in community health centres, while smoking cessation care and weight management was higher in the blended-capitation models. Fee-for-service practices had the greatest gaps in care, most noticeably in

  17. Providing end-of-life care in disability community living services: An organizational capacity-building model using a public health approach.

    Science.gov (United States)

    Grindrod, Andrea; Rumbold, Bruce

    2017-11-01

    There is broad consensus within the disability field that the end-of-life care offered to people with intellectual disabilities should be of a quality consistent with that advocated by contemporary palliative care. In practice, however, various barriers are encountered when applying palliative care strategies to the end-of-life care of people with intellectual disabilities, particularly those in disability community living services. A mixed-methods approach was used. Quantitative data were gathered through a survey of disability support staff working in government-managed community living services in the Australian state of Victoria. These quantitative data informed the collection of qualitative data through focus groups and research interviews. A public health palliative care framework provided the basis for developing an organizational change model from the consolidated data. There is a strong relationship between organizational structure and culture, and both influence end-of-life practice in community living services. Barriers to good practice arise from the differing attitudes of paid carers involved, and from uncoordinated approaches reflecting misaligned service systems in the disability and palliative care fields. Organizational reorientation is crucial to achieving sustainable change that will support healthy dying. End-of-life care requires the collaboration of disability and palliative care services, but for care to achieve palliative care goals, the collaboration must be led by disability services. We outline here an organizational model we have developed from public health principles to manage end-of-life care in community living services. © 2017 John Wiley & Sons Ltd.

  18. A numerical model for self-compacting concrete flow through reinforced sections. A porous medium analogy

    Energy Technology Data Exchange (ETDEWEB)

    Vasilic, Ksenija

    2016-05-01

    This thesis addresses numerical simulations of self-compacting concrete (SCC) castings and suggests a novel modelling approach that treats reinforcement zones in a formwork as porous media. As a relatively new field in concrete technology, numerical simulations of fresh concrete flow can be a promising aid to optimise casting processes and to avoid on-site casting incidents by predicting the flow behaviour of concrete during the casting process. The simulations of fresh concrete flow generally involve complex mathematical modelling and time-consuming computations. In case of a casting prediction, the simulation time is additionally significantly increased because each reinforcement bar occurring in succession has to be considered one by one. This is particularly problematic when simulating SCC casting, since this type of concrete is typically used for heavily reinforced structural members. However, the wide use of numerical tools for casting prediction in practice is possible only if the tools are user-friendly and simulations are time-saving. In order to shorten simulation time and to come closer to a practical tool for casting prediction, instead to model steel bars one by one, this thesis suggests to model zones with arrays of steel bars as porous media. Consequently, one models the flow of SCC through a reinforcement zone as a free-surface flow of a non-Newtonian fluid, propagating through the medium. By defining characteristic parameters of the porous medium, the influence on the flow and the changed (apparent) behaviour of concrete in the porous matrix can be predicted. This enables modelling of any reinforcement network as a porous zone and thus significantly simplifies and fastens simulations of reinforced components' castings. Within the thesis, a computational model for SCC flow through reinforced sections was developed. This model couples a fluid dynamics model for fresh concrete and the macroscopic approach for the influence of the porous medium

  19. A numerical model for self-compacting concrete flow through reinforced sections. A porous medium analogy

    International Nuclear Information System (INIS)

    Vasilic, Ksenija

    2016-01-01

    This thesis addresses numerical simulations of self-compacting concrete (SCC) castings and suggests a novel modelling approach that treats reinforcement zones in a formwork as porous media. As a relatively new field in concrete technology, numerical simulations of fresh concrete flow can be a promising aid to optimise casting processes and to avoid on-site casting incidents by predicting the flow behaviour of concrete during the casting process. The simulations of fresh concrete flow generally involve complex mathematical modelling and time-consuming computations. In case of a casting prediction, the simulation time is additionally significantly increased because each reinforcement bar occurring in succession has to be considered one by one. This is particularly problematic when simulating SCC casting, since this type of concrete is typically used for heavily reinforced structural members. However, the wide use of numerical tools for casting prediction in practice is possible only if the tools are user-friendly and simulations are time-saving. In order to shorten simulation time and to come closer to a practical tool for casting prediction, instead to model steel bars one by one, this thesis suggests to model zones with arrays of steel bars as porous media. Consequently, one models the flow of SCC through a reinforcement zone as a free-surface flow of a non-Newtonian fluid, propagating through the medium. By defining characteristic parameters of the porous medium, the influence on the flow and the changed (apparent) behaviour of concrete in the porous matrix can be predicted. This enables modelling of any reinforcement network as a porous zone and thus significantly simplifies and fastens simulations of reinforced components' castings. Within the thesis, a computational model for SCC flow through reinforced sections was developed. This model couples a fluid dynamics model for fresh concrete and the macroscopic approach for the influence of the porous medium

  20. Integrating Model-Driven and Data-Driven Techniques for Analyzing Learning Behaviors in Open-Ended Learning Environments

    Science.gov (United States)

    Kinnebrew, John S.; Segedy, James R.; Biswas, Gautam

    2017-01-01

    Research in computer-based learning environments has long recognized the vital role of adaptivity in promoting effective, individualized learning among students. Adaptive scaffolding capabilities are particularly important in open-ended learning environments, which provide students with opportunities for solving authentic and complex problems, and…

  1. Pathways to Carbon Neutral Industrial Sectors: Integrated Modelling Approach with High Level of Detail for End-use Processes

    DEFF Research Database (Denmark)

    Industry constitutes a substantial share of the energy and fuel consumption in energy systems. Types and patterns of usage within different industrial sectors are diverse. In this paper, we illustrate the energy and fuel use in Danish industry by 24 end-uses and 20 fuels and provide hourly profil...

  2. Play it forward : A Game-based tool for Sustainable Product and Business Model Innovation in the Fuzzy Front End

    NARCIS (Netherlands)

    Dewulf, K.R.

    2010-01-01

    Dealing with sustainability in the fuzzy front end of innovation is complex and often hard. There are a number of tools available to guide designers, engineers and managers in the design process after the specifications of the product or service are already set, but methods supporting goal finding

  3. Challenging fission cross section simulation with long standing macro-microscopic model of nucleus potential energy surface

    International Nuclear Information System (INIS)

    Tamagno, Pierre

    2015-01-01

    The work presented here aims to improve models used in the fission cross section evaluation. The results give insights for a significant breakthrough in this field and yielded large extensions of the evaluation code CONRAD. Partial cross sections are inherently strongly correlated together as of the competition of the related reactions must yield the total cross section. Therefore improving fission cross section benefits to all partial cross sections. A sound framework for the simulation of competitive reactions had to be settled in order to further investigate on the fission reaction; this was implemented using the TALYS reference code as guideline. After ensuring consistency and consistency of the framework, focus was made on fission. Perspective resulting from the use of macroscopic-microscopic models such as the FRDM and FRLDM were analyzed; these models have been implemented and validated on experimental data and benchmarks. To comply with evaluation requirements in terms of computation time, several specific numerical methods have been used and parts of the program were written to run on GPU. These macroscopic-microscopic models yield potential energy surfaces that can be used to extract a one-dimensional fission barrier. This latter can then be used to obtained fission transmission coefficients that can be used in a Hauser-Feshbach model. This method has been finally tested for the calculation of the average fission cross section for 239 Pu(n,f). (author) [fr

  4. Flexural Behavior of Concrete Beam Strengthened by Near-Surface Mounted CFRP Reinforcement Using Equivalent Section Model

    Directory of Open Access Journals (Sweden)

    Woo-tai Jung

    2017-01-01

    Full Text Available FRP (fiber reinforced polymer has found wide applications as an alternative to steel rebar not only for the repair and strengthening of existing structures but also for the erection of new structures. Near-surface mounted (NSM strengthening was introduced as an alternative of externally bonded reinforcement (EBR but this method also experiences early bond failure, which stresses the importance of predicting accurately the bond failure behavior in order to evaluate precisely the performance of NSM reinforcement. This study proposes the equivalent section model assuming monolithic behavior of the filler and CFRP reinforcement. This equivalent section model enables establishing a bond failure model applicable independently of the sectional shape of the CFRP reinforcement. This so-derived bond failure model is then validated experimentally by means of beams flexure-strengthened by NSM CFRP reinforcements with various cross-sections. Finally, analytical analysis applying the bond failure model considering the equivalent section and defined failure criteria is performed. The results show the accuracy of the prediction of the failure mode as well as the accurate prediction of the experimental results regardless of the sectional shape of the CFRP reinforcement.

  5. Representation of Nucleation Mode Microphysics in a Global Aerosol Model with Sectional Microphysics

    Science.gov (United States)

    Lee, Y. H.; Pierce, J. R.; Adams, P. J.

    2013-01-01

    In models, nucleation mode (1 nmrepresentation of nucleation mode microphysics impacts aerosol number predictions in the TwO-Moment Aerosol Sectional (TOMAS) aerosol microphysics model running with the GISS GCM II-prime by varying its lowest diameter boundary: 1 nm, 3 nm, and 10 nm. The model with the 1 nm boundary simulates the nucleation mode particles with fully resolved microphysical processes, while the model with the 10 nm and 3 nm boundaries uses a nucleation mode dynamics parameterization to account for the growth of nucleated particles to 10 nm and 3 nm, respectively.We also investigate the impact of the time step for aerosol microphysical processes (a 10 min versus a 1 h time step) to aerosol number predictions in the TOMAS models with explicit dynamics for the nucleation mode particles (i.e., 3 nm and 1 nm boundary). The model with the explicit microphysics (i.e., 1 nm boundary) with the 10 min time step is used as a numerical benchmark simulation to estimate biases caused by varying the lower size cutoff and the time step. Different representations of the nucleation mode have a significant effect on the formation rate of particles larger than 10 nm from nucleated particles (J10) and the burdens and lifetimes of ultrafinemode (10 nm=Dp =70 nm) particles but have less impact on the burdens and lifetimes of CCN-sized particles. The models using parameterized microphysics (i.e., 10 nm and 3 nm boundaries) result in higher J10 and shorter coagulation lifetimes of ultrafine-mode particles than the model with explicit dynamics (i.e., 1 nm boundary). The spatial distributions of CN10 (Dp =10 nm) and CCN(0.2 %) (i.e., CCN concentrations at 0.2%supersaturation) are moderately affected, especially CN10 predictions above 700 hPa where nucleation contributes most strongly to CN10 concentrations. The lowermost-layer CN10 is substantially improved with the 3 nm boundary (compared to 10 nm) in most areas. The overprediction in CN10 with the 3 nm and 10 nm boundaries

  6. Standardizing information exchange towards the end user. Present data models with two way communication over the Internet

    International Nuclear Information System (INIS)

    Saele, Hanne; Graabak, Ingeborg; Tangen, Grethe

    2000-01-01

    The two-way communication towards the end consumer is in little use so far. There are probably several reasons for this but one important reason may be the lack of standardized interfaces for the information exchange towards the end user. The lack of such standards results in substantial system investment risks for the network companies because the systems may not be developed further and maintained should the deliverer leave the market. The communication channel Internet has expanded quickly and in Norway of today (1999) 25 to 30 % of the households have an Internet connection. The use of existing infrastructure and already tried out technology for information transferrals may contribute to making two-way communication more reasonable and functional. In the report various alternatives of standardized information exchange towards the end users are evaluated. Various formats are discussed with the following demands in mind: 1) Shall be suited for all types of communication media. 2) An international standard followed by everyone. 3) Reliable information transferral and flexible. The focus is on what kind of information is being transferred and how this is organized, and not on how the information is transferred. The discussed alternatives are evaluated both regarding traditional solutions for two- way communication and the use of the Internet. The following format alternatives are discussed: EDIEL/EDIFACT, ODEL(GS2), LonWorks/Echelon, UCA, DLMS/COSEM, COBRA and DCOM. The formats represent communication at various levels but they are mentioned in the report because they are often mentioned as possible standard formats towards the end user: ODEL, DLSM/COSEM and UCA. EDIEL is not suited for this interface. The market for two-way communication systems is international and it does not seem to be practical to establish a joint Norwegian/Swedish standard. The work with establishing one standard should therefore be continued through international standardization

  7. Tool flank wear model and parametric optimization in end milling of metal matrix composite using carbide tool: Response surface methodology approach

    Directory of Open Access Journals (Sweden)

    R. Arokiadass

    2012-04-01

    Full Text Available Highly automated CNC end milling machines in manufacturing industry requires reliable model for prediction of tool flank wear. This model later can be used to predict the tool flank wear (VBmax according to the process parameters. In this investigation an attempt was made to develop an empirical relationship to predict the tool flank wear (VBmax of carbide tools while machining LM25 Al/SiCp incorporating the process parameters such as spindle speed (N, feed rate (f, depth of cut (d and various % wt. of silicon carbide (S. Response surface methodology (RSM was applied to optimizing the end milling process parameters to attain the minimum tool flank wear. Predicted values obtained from the developed model and experimental results are compared, and error <5 percent is observed. In addition, it is concluded that the flank wear increases with the increase of SiCp percentage weight in the MMC.

  8. Bayesian variable selection in the accelerated failure time model with an application to the surveillance, epidemiology, and end results breast cancer data.

    Science.gov (United States)

    Zhang, Zhen; Sinha, Samiran; Maiti, Tapabrata; Shipp, Eva

    2018-04-01

    Accelerated failure time model is a popular model to analyze censored time-to-event data. Analysis of this model without assuming any parametric distribution for the model error is challenging, and the model complexity is enhanced in the presence of large number of covariates. We developed a nonparametric Bayesian method for regularized estimation of the regression parameters in a flexible accelerated failure time model. The novelties of our method lie in modeling the error distribution of the accelerated failure time nonparametrically, modeling the variance as a function of the mean, and adopting a variable selection technique in modeling the mean. The proposed method allowed for identifying a set of important regression parameters, estimating survival probabilities, and constructing credible intervals of the survival probabilities. We evaluated operating characteristics of the proposed method via simulation studies. Finally, we apply our new comprehensive method to analyze the motivating breast cancer data from the Surveillance, Epidemiology, and End Results Program, and estimate the five-year survival probabilities for women included in the Surveillance, Epidemiology, and End Results database who were diagnosed with breast cancer between 1990 and 2000.

  9. Knowledge fusion: Time series modeling followed by pattern recognition applied to unusual sections of background data

    International Nuclear Information System (INIS)

    Burr, T.; Doak, J.; Howell, J.A.; Martinez, D.; Strittmatter, R.

    1996-03-01

    This report describes work performed during FY 95 for the Knowledge Fusion Project, which by the Department of Energy, Office of Nonproliferation and National Security. The project team selected satellite sensor data as the one main example to which its analysis algorithms would be applied. The specific sensor-fusion problem has many generic features that make it a worthwhile problem to attempt to solve in a general way. The generic problem is to recognize events of interest from multiple time series in a possibly noisy background. By implementing a suite of time series modeling and forecasting methods and using well-chosen alarm criteria, we reduce the number of false alarms. We then further reduce the number of false alarms by analyzing all suspicious sections of data, as judged by the alarm criteria, with pattern recognition methods. This report describes the implementation and application of this two-step process for separating events from unusual background. As a fortunate by-product of this activity, it is possible to gain a better understanding of the natural background

  10. When machine vision meets histology: A comparative evaluation of model architecture for classification of histology sections.

    Science.gov (United States)

    Zhong, Cheng; Han, Ju; Borowsky, Alexander; Parvin, Bahram; Wang, Yunfu; Chang, Hang

    2017-01-01

    Classification of histology sections in large cohorts, in terms of distinct regions of microanatomy (e.g., stromal) and histopathology (e.g., tumor, necrosis), enables the quantification of tumor composition, and the construction of predictive models of genomics and clinical outcome. To tackle the large technical variations and biological heterogeneities, which are intrinsic in large cohorts, emerging systems utilize either prior knowledge from pathologists or unsupervised feature learning for invariant representation of the underlying properties in the data. However, to a large degree, the architecture for tissue histology classification remains unexplored and requires urgent systematical investigation. This paper is the first attempt to provide insights into three fundamental questions in tissue histology classification: I. Is unsupervised feature learning preferable to human engineered features? II. Does cellular saliency help? III. Does the sparse feature encoder contribute to recognition? We show that (a) in I, both Cellular Morphometric Feature and features from unsupervised feature learning lead to superior performance when compared to SIFT and [Color, Texture]; (b) in II, cellular saliency incorporation impairs the performance for systems built upon pixel-/patch-level features; and (c) in III, the effect of the sparse feature encoder is correlated with the robustness of features, and the performance can be consistently improved by the multi-stage extension of systems built upon both Cellular Morphmetric Feature and features from unsupervised feature learning. These insights are validated with two cohorts of Glioblastoma Multiforme (GBM) and Kidney Clear Cell Carcinoma (KIRC). Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Utilizing Domain Knowledge in End-to-End Audio Processing

    DEFF Research Database (Denmark)

    Tax, Tycho; Antich, Jose Luis Diez; Purwins, Hendrik

    2017-01-01

    End-to-end neural network based approaches to audio modelling are generally outperformed by models trained on high-level data representations. In this paper we present preliminary work that shows the feasibility of training the first layers of a deep convolutional neural network (CNN) model...... to learn the commonly-used log-scaled mel-spectrogram transformation. Secondly, we demonstrate that upon initializing the first layers of an end-to-end CNN classifier with the learned transformation, convergence and performance on the ESC-50 environmental sound classification dataset are similar to a CNN...

  12. End-Users, Front Ends and Librarians.

    Science.gov (United States)

    Bourne, Donna E.

    1989-01-01

    The increase in end-user searching, the advantages and limitations of front ends, and the role of the librarian in end-user searching are discussed. It is argued that librarians need to recognize that front ends can be of benefit to themselves and patrons, and to assume the role of advisors and educators for end-users. (37 references) (CLB)

  13. Effects of different metabolic states and surgical models on glucose metabolism and secretion of ileal L-cell peptides: protocol for a cross-sectional study.

    Science.gov (United States)

    Celik, Alper; Dixon, John B; Pouwels, Sjaak; Celik, Bahri Onur; Karaca, Fatih Can; Gupta, Adarsh; Santoro, Sergio; Ugale, Surendra

    2016-03-14

    Obesity and type 2 diabetes mellitus are increasing worldwide, reaching pandemic proportions. The understanding of the role of functional restriction and gut hormones can be a beneficial tool in treating obesity and diabetes. However, the exact hormonal profiles in different metabolic states and surgical models are not known. The HIPER-1 Study is a single-centre cross-sectional study in which 240 patients (in different metabolic states and surgical models) will receive an oral mixed-meal tolerance test (OMTT). At baseline and after 30, 60 and 120 min, peptide YY and glucagon-like peptide 1 levels and glucose and insulin sensitivity will be measured. The primary end point of the study will be the area under the glucagon-like peptide 1 and peptide YY curves after the OMTT. Secondary study end points will include examination of the difference in plasma levels of the distal ileal hormones in subjects with various health statuses and in patients who have been treated with different surgical techniques. An independent ethics committee, the Institutional Review Board of Istanbul Sisli Kolan International Hospital, Turkey, has approved the study protocol. Dissemination will occur via publication, national and international conference presentations, and exchanges with regional, provincial and national stakeholders. NCT02532829; Pre-results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  14. Statistical Model Analysis of (n, α Cross Sections for 4.0-6.5 MeV Neutrons

    Directory of Open Access Journals (Sweden)

    Khuukhenkhuu G.

    2016-01-01

    Full Text Available The statistical model based on the Weisskopf-Ewing theory and constant nuclear temperature approximation is used for systematical analysis of the 4.0-6.5 MeV neutron induced (n, α reaction cross sections. The α-clusterization effect was considered in the (n, α cross sections. A certain dependence of the (n, α cross sections on the relative neutron excess parameter of the target nuclei was observed. The systematic regularity of the (n, α cross sections behaviour is useful to estimate the same reaction cross sections for unstable isotopes. The results of our analysis can be used for nuclear astrophysical calculations such as helium burning and possible branching in the s-process.

  15. Development of a cross-section methodology and a real-time core model for VVER-1000 simulator application

    Energy Technology Data Exchange (ETDEWEB)

    Georgieva, Emiliya Lyudmilova

    2016-06-06

    The novel academic contributions are summarized as follows. A) A cross-section modelling methodology and a cycle-specific cross-section update procedure are developed to meet fidelity requirements applicable to a cycle-specific reactor core simulation, as well as particular customer needs and practices supporting VVER-1000 operation and safety. B) A real-time version of the Nodal Expansion Method code is developed and implemented into Kozloduy 6 full-scope replica control room simulator.

  16. Modeling fluid flow in open channel with circular cross‐section ...

    African Journals Online (AJOL)

    Flow in a closed conduit is regarded as open channel flow, if it has a free surface. This study considers unsteady non]uniform open channel flow in a closed conduit with circular cross]section. We investigate the effects of the flow depth, the cross section area of flow, channel radius, slope of the channel, roughness coefficient ...

  17. Measurement of the cross-section of Zγ and limits on ADD models at ...

    Indian Academy of Sciences (India)

    The measurement of the inclusive cross-section for Z production at LHC with 7 TeV proton–proton collision is presented. The electron and muon decay modes are used to reconstruct the boson. The total cross-section is measured for photon transverse energy greater than 10 GeV and with photon and charged lepton ...

  18. Shape dependency of the extinction and absorption cross sections of dust aerosols modeled as randomly oriented spheroids

    Directory of Open Access Journals (Sweden)

    R. Wagner

    2011-09-01

    Full Text Available We present computational results on the shape dependency of the extinction and absorption cross sections of dustlike aerosol particles that were modeled as randomly oriented spheroids. Shape dependent variations in the extinction cross sections are largest in the size regime that is governed by the interference structure. Elongated spheroids best fitted measured extinction spectra of re-dispersed Saharan dust samples. For dust particles smaller than 1.5 μm in diameter and low absorption potential, shape effects on the absorption cross sections are very small.

  19. Structural Analysis of an Integrated Model of Short Straight Section, Service Module, Jumper Connection and Magnet Interconnects for the Large Hadron Collider

    CERN Document Server

    Dutta, S; Kumar, A; Skoczen, B; Soni, H C

    2004-01-01

    The Short Straight Section (SSS) of the Large Hadron Collider (LHC) may undergo relative displacements between cold-mass and cryostat for the following three reasons: - Fabrication tolerance of interconnection bellows - Global smoothing after pre-alignment - Ground motion in a sector of the LHC tunnel The forces responsible for such displacements stem from finite stiffness of interconnect bellows & metal hoses of the internal piping of the jumper connection and from relatively flexible 'glass fibre reinforced epoxy' (GFRE) composite supports of the cold mass. In addition, the vacuum jacket of the jumper connection and the large sleeves attached to both ends of SSS produce elastic deformations of the cryostat vessel. A unified finite element model consisting of cryostat, large sleeves, vacuum jacket of jumper, interconnection bellows, internal piping of jumper, composite cold supports and alignment jacks has been prepared. The knowledge of the position of the cold mass with respect to its cryostat under va...

  20. Modeling of cognitive impairment by disease duration in multiple sclerosis: a cross-sectional study.

    Directory of Open Access Journals (Sweden)

    Anat Achiron

    Full Text Available BACKGROUND/AIMS: Large-scale population studies measuring rates and dynamics of cognitive decline in multiple sclerosis (MS are lacking. In the current cross-sectional study we evaluated the patterns of cognitive impairment in MS patients with disease duration of up to 30 years. METHODS: 1,500 patients with MS were assessed by a computerized cognitive battery measuring verbal and non-verbal memory, executive function, visual spatial perception, verbal function, attention, information processing speed and motor skills. Cognitive impairment was defined as below one standard deviation (SD and severe cognitive impairment as below 2SD for age and education matched healthy population norms. RESULTS: Cognitive performance in our cohort was poorer than healthy population norms. The most frequently impaired domains were information processing speed and executive function. MS patients with secondary-progressive disease course performed poorly compared with clinically isolated syndrome, relapsing-remitting and primary progressive MS patients. By the fifth year from disease onset, 20.9% of patients performed below the 1SD cutoff for impairment, p=0.005, and 6.0% performed below the 2SD cutoff for severe cognitive impairment, p=0.002. By 10 years from onset 29.3% and 9.0% of patients performed below the 1SD and 2SD cutoffs, respectively, p=0.0001. Regression modeling suggested that cognitive impairment may precede MS onset by 1.2 years. CONCLUSIONS: The rates of cognitive impairment in this large sample of MS patients were lower than previously reported and severe cognitive impairment was evident only in a relatively small group of patients. Cognitive impairment differed significantly from expected normal distribution only at five years from onset, suggesting the existence of a therapeutic window during which patients may benefit from interventions to maintain cognitive health.

  1. Nursing Care Model Based on Knowledge Management in Preventing Nosocomial Infection After Caesarean Section in Hospital

    Directory of Open Access Journals (Sweden)

    Ahsan Ahsan

    2016-09-01

    Full Text Available Introduction: Nosocomial infection is one indicator of the quality of health services in the community, which also determines the image of health care institutions becauseit was a major cause of morbidityand death rate (mortality in hospital. Nursing care based on knowledge management is established from identification knowledge which is required, prevention performance of nosocomial infections post section caesarea. Nosocomial infections component consists of wound culture result. Method: This study was an observational study with a quasi experimental design. The population was all of nursing staff who working in obstetrics installation in hospitals A and B as much as 46 people. Sample was the total population. Data was collected through questionnaire, observation sheets and examination of the wound culture. Data was analyzed using t test B 1.274 dan p=0.028 Result: The result showed that 1 there was difference in knowledge management implementation before and after training; 2 there was difference in nurse’s performance in preventing nosocomial infection before and after training; 3 there is significant relationship between nurse’s performance in preventing nosocomial infection and infection incidence; 4 there is no significant difference of nursing care impementation on nosocomial incidence. Discussion: In conclusion, the development of nursing care based on knowledge management as a synthesis or induction of findings directed at 1 nurses’ knowledge does not affect the performance of the prevention of nosocomial infections; 2 knowledge management has a positive effect on the performance of the prevention of nosocomial infections; 3 implementation of infection prevention is integrated capabilities between knowledge, skills and attitudes of nurses in implementing performance in care. Keywords: model prevention, nosocomial infections, nursing care, knowledge management, sectio Caesarea

  2. A Model for Art Therapy-Based Supervision for End-of-Life Care Workers in Hong Kong.

    Science.gov (United States)

    Potash, Jordan S; Chan, Faye; Ho, Andy H Y; Wang, Xiao Lu; Cheng, Carol

    2015-01-01

    End-of-life care workers and volunteers are particularly prone to burnout given the intense emotional and existential nature of their work. Supervision is one important way to provide adequate support that focuses on both professional and personal competencies. The inclusion of art therapy principles and practices within supervision further creates a dynamic platform for sustained self-reflection. A 6-week art therapy-based supervision group provided opportunities for developing emotional awareness, recognizing professional strengths, securing collegial relationships, and reflecting on death-related memories. The structure, rationale, and feedback are discussed.

  3. Analysis on learning curves of end-use appliances for the establishment of price-sensitivity load model in competitive electricity market

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Sung Wook; Kim, Jung Hoon [Hongik University (Korea); Song, Kyung Bin [Keimyung University (Korea); Choi, Joon Young [Jeonju University (Korea)

    2001-07-01

    The change of the electricity charge from cost base to price base due to the introduction to the electricity market competition causes consumer to choose a variety of charge schemes and a portion of loads to be affected by this change. Besides, it is required the index that consolidate the price volatility experienced on the power exchange with gaming and strategic bidding by suppliers to increase profits. Therefore, in order to find a mathematical model of the sensitively-responding to-price loads, the price-sensitive load model is needed. And the development of state-of- the-art technologies affects the electricity price, so the diffusion of high-efficient end-uses and these price affect load patterns. This paper shows the analysis on learning curves algorithms which is used to investigate the correlation of the end-uses' price and load patterns. (author). 6 refs., 4 figs., 4 tabs.

  4. Workshop on electronic and ionic collision cross sections needed in the modeling of radiation interactions with matter: proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1984-05-01

    The term modeling in the Workship title refers to the mathematical analysis of the consequences of many collision processes for characterizing the physical stage of radiation actions. It requires as input some knowledge of collision cross sections. Traditionally, work on cross sections and work on the modeling are conducted by separate groups of scientists. It was the purpose of the Workshop to bring these two groups together in a forum that would promote effective communication. Cross-section workers described the status of their work and told what data were available or trustworthy. Modeling workers told what kind of data were needed or were most important. Twenty-two items from the workshop were prepared separately for the data base.

  5. Workshop on electronic and ionic collision cross sections needed in the modeling of radiation interactions with matter: proceedings

    International Nuclear Information System (INIS)

    1984-05-01

    The term modeling in the Workship title refers to the mathematical analysis of the consequences of many collision processes for characterizing the physical stage of radiation actions. It requires as input some knowledge of collision cross sections. Traditionally, work on cross sections and work on the modeling are conducted by separate groups of scientists. It was the purpose of the Workshop to bring these two groups together in a forum that would promote effective communication. Cross-section workers described the status of their work and told what data were available or trustworthy. Modeling workers told what kind of data were needed or were most important. Twenty-two items from the workshop were prepared separately for the data base

  6. Statistical downscaling of multi-decadal climate change projections: Bridging the gap between climate models and the end-user

    CSIR Research Space (South Africa)

    Landman, WA

    2013-09-01

    Full Text Available temperatures across the region. The statistical model is found to be able to replicate the increasing maximum temperature trends of the driving regional climate model. Since dry-land crops are not explicitly produced by climate models but are sensitive...

  7. On the Potential of Functional Modeling Extensions to the CIM for Means-Ends Representation and Reasoning

    DEFF Research Database (Denmark)

    Heussen, Kai; Kullmann, Daniel

    2010-01-01

    Engineering is the art of making complicated things work. There are few things an engineer can’t do. Explaining his work to a computer may be one of them. This paper introduces Functional Modeling with Multilevel Flow Models as an information modeling approach that explicitly relates the functions...

  8. EKSPERIMENTASI MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE (TPS DENGAN PENDEKATAN OPEN-ENDED DITINJAU DARI DISPOSISI MATEMATIS SISWA KELAS VIII SMP NEGERI DI KABUPATEN PURWOREJO

    Directory of Open Access Journals (Sweden)

    Zainnur Wijayanto

    2015-02-01

    Full Text Available prestasi belajar matematika lebih baik, siswa dengan disposisi matematis tinggi, sedang, atau rendah, 4 pada masing-masing kategori disposisi matematis, manakah yang mempunyai prestasi belajar matematika lebih baik, siswa yang dikenai model pembelajaran kooperatif tipe TPS dengan pendekatan open-ended atau pembelajaran langsung. Penelitian ini merupakan penelitian eksperimental semu. Populasi penelitian ini adalah siswa kelas VIII SMP Negeri di Kabupaten Purworejo tahun ajaran 2013/2014. Sampel dalam penelitian ini adalah siswa SMPN 20 Purworejo, SMPN 14 Purworejo, SMPN 13 Purworejo yang diambil secara stratified cluster random sampling. Instrumen yang digunakan untuk mengumpulkan data adalah instrumen tes prestasi belajar matematika, instrumen angket disposisi matematis siswa. Teknik analisis data yang digunakan adalah uji hipotesis menggunakan anava dua jalan dengan sel tak sama. Dari hasil analisis disimpulkan bahwa : 1 prestasi belajar matematika siswa yang diberi pembelajaran dengan model pembelajaran kooperatif tipe TPS dengan pendekatan open-ended lebih baik daripada siswa yang diberi pembelajaran langsung, 2 prestasi belajar matematika siswa dengan disposisi matematis tinggi lebih baik daripada siswa dengan disposisi matematis sedang dan rendah, begitu juga dengan prestasi belajar matematika siswa dengan disposisi matematis sedang lebih baik daripada siswa dengan disposisi matematis rendah, 3 pada model pembelajaran kooperatif tipe TPS dengan pendekatan open-ended prestasi belajar matematika siswa yang memiliki disposisi matematis tinggi lebih baik daripada siswa yang memiliki disposisi matematis sedang maupun rendah. Pada pembelajaran langsung, siswa dengan disposisi matematis tinggi memiliki prestasi belajar yang lebih baik daripada siswa yang memiliki disposisi matematis sedang dan rendah, siswa dengan disposisi matematis sedang memiliki prestasi belajar yang sama dengan siswa yang memiliki disposisi matematis rendah, 4 Pada siswa

  9. A model for emergency department end-of-life communications after acute devastating events--part I: decision-making capacity, surrogates, and advance directives.

    Science.gov (United States)

    Limehouse, Walter E; Feeser, V Ramana; Bookman, Kelly J; Derse, Arthur

    2012-09-01

    Making decisions for a patient affected by sudden devastating illness or injury traumatizes a patient's family and loved ones. Even in the absence of an emergency, surrogates making end-of-life treatment decisions may experience negative emotional effects. Helping surrogates with these end-of-life decisions under emergent conditions requires the emergency physician (EP) to be clear, making medical recommendations with sensitivity. This model for emergency department (ED) end-of-life communications after acute devastating events comprises the following steps: 1) determine the patient's decision-making capacity; 2) identify the legal surrogate; 3) elicit patient values as expressed in completed advance directives; 4) determine patient/surrogate understanding of the life-limiting event and expectant treatment goals; 5) convey physician understanding of the event, including prognosis, treatment options, and recommendation; 6) share decisions regarding withdrawing or withholding of resuscitative efforts, using available resources and considering options for organ donation; and 7) revise treatment goals as needed. Emergency physicians should break bad news compassionately, yet sufficiently, so that surrogate and family understand both the gravity of the situation and the lack of long-term benefit of continued life-sustaining interventions. EPs should also help the surrogate and family understand that palliative care addresses comfort needs of the patient including adequate treatment for pain, dyspnea, or anxiety. Part I of this communications model reviews determination of decision-making capacity, surrogacy laws, and advance directives, including legal definitions and application of these steps; Part II (which will appear in a future issue of AEM) covers communication moving from resuscitative to end-of-life and palliative treatment. EPs should recognize acute devastating illness or injuries, when appropriate, as opportunities to initiate end-of-life discussions and to

  10. Evaluation of the nuclear cross section variance-covariance matrices issued from the nuclear optical model; Evaluation des matrices de variance-covariance des sections efficaces nucleaires issues du modele optique

    Energy Technology Data Exchange (ETDEWEB)

    Brassart, M. [Ecole Nationale Superieure Ingenieurs de Bourges, 18 - Bourges (France); Mounier, C. [CEA Saclay, Dir. de l' Energie Nucleaire DEN, Service d' Etudes des Reacteurs et de Modelisation Avancee, 91 - Gif sur Yvette (France); Dossantos-Uzarralde, P. [CEA Bruyeres le Chatel, 91 (France). Dept. de Physique Theorique et Appliquee

    2004-07-01

    Nuclear reaction models play an important role in today's nuclear data evaluations. There are, however, difficulties associated with evaluating data uncertainties, both while performing the experimental measurements as well as constructing them by nuclear models. In this general context, our interest is particularly targeted towards the study of the propagation uncertainties within nuclear models. In this report we discuss two distinct ways of calculating the nuclear cross section variance-covariance matrices and then show these can be applied to the nuclear spherical optical model. (authors)

  11. Multigroup cross section collapsing optimization of a He-3 detector assembly model using deterministic transport techniques

    International Nuclear Information System (INIS)

    Huang, Mi; Yi, Ce; Manalo, Kevin L.; Sjoden, Glenn E.

    2011-01-01

    Multigroup optimization is performed on a neutron detector assembly to examine the validity of transport response in forward and adjoint modes. For SN transport simulations, we discuss the multigroup collapse of an 80 group library to 40, 30, and 16 groups, constructed from using the 3-D parallel PENTRAN and macroscopic cross section collapsing with YGROUP contribution weighting. The difference in using P 1 and P 3 Legendre order in scattering cross sections is investigated; also, associated forward and adjoint transport responses are calculated. We conclude that for the block analyzed, a 30 group cross section optimizes both computation time and accuracy relative to the 80 group transport calculations. (author)

  12. Reaction of oxygen with γ, δ-ethylenic phenylhydrazones. Model reaction of end-group behavior in phenylhydrazine-accelerated oxidation of natural rubber

    International Nuclear Information System (INIS)

    El Hamdaoui, A.; Reyx, D.; Campistron, I.

    1995-01-01

    An accurate definition of terminal groups of chains in the liquid polymers obtained by the phenylhydrazine-accelerated oxidation of natural rubber is needed. The object of the work was to use model molecules to explore the behavior of γ,δ-ethylenic methylketone phenylhydrazone end-groups in oxidation conditions. We have investigated the synthesis and characterization of models of these hypothetical end-groups, methylketones and phenones 1, their phenylhydrazones 2, the α-(phenyldiazenyl)hydroperoxides 3 resulting from reaction of 2 with oxygen, and the α-(phenyldiazenyl)alcohols 4 as characteristic derivatives of 3 or as models of possible reduced structures in oxidized liquid natural rubber. Three original syntheses of γ,δ-ethylenic ketones were carried out. In the case of γ,δ-ethylenic phenylhydrazones, the oxidation led to the expected α-(phenyldiazenyl)hydroperoxides and to epoxide derivatives of α-(phenyldiazenyl)alcohols 5 and ketones 6. An intramolecular mechanism is proposed. The results are used to predict the possibilities of identification of the corresponding end-groups in liquid rubbers produced in this way. (authors). 16 refs., 12 figs., 3 tabs

  13. Biomarker case-detection and prediction with potential for functional psychosis screening: development and validation of a model related to biochemistry, sensory neural timing and end organ performance.

    Directory of Open Access Journals (Sweden)

    Stephanie eFryar-Williams

    2016-04-01

    Full Text Available The Mental Health Biomarker Project aimed to discover case-predictive biomarkers for functional psychosis. In a retrospective, cross-sectional study, candidate marker results from 67, highly-characterized symptomatic participants were compared with results from 67 gender and age matched controls. Urine samples were analysed for catecholamines, their metabolites and hydroxylpyrolline-2-one, an oxidative stress marker. Blood samples were analyzed for vitamin and trace element cofactors of enzymes in the catecholamine synthesis and metabolism pathways. Cognitive, auditory and visual processing measures were assessed using a simple 45 minute, office-based procedure. Receiver Operating Curve (ROC and Odds Ratio analysis discovered biomarkers for deficits in folate, vitamin D and B6 and elevations in free copper to zinc ratio, catecholamines and the oxidative stress marker. Deficits were discovered in peripheral visual and auditory end-organ function, intra-cerebral auditory and visual processing speed and dichotic-listening performance. 15 ROC biomarker variables were divided into 5 functional domains. Through a repeated ROC process, individual ROC variables, followed by domains and finally the overall 15 set model, were dichotomously scored and tallied for abnormal results upon which it was found that ≥ 3 out of 5 abnormal domains achieved an AUC of 0.952 with a sensitivity of 84 per cent and a specificity of 90 percent. Six additional middle ear biomarkers in a 21 biomarker set increased sensitivity to 94% percent. Fivefold cross-validation yielded a mean sensitivity of 85% for the 15 biomarker set. Non-parametric regression analysis confirmed that ≥ 3 out of 5 abnormally scored domains predicted > 50% risk of case-ness whilst 4 abnormally-scored domains predicted 88% risk of case-ness and 100% diagnostic certainty was reached when all 5 domains were abnormally scored. These findings require validation in prospective cohorts and other mental

  14. Current HIV/AIDS end-of-life care in sub-Saharan Africa: a survey of models, services, challenges and priorities

    Directory of Open Access Journals (Sweden)

    O'Neill Joseph F

    2003-10-01

    Full Text Available Abstract Background In response to increased global public health funding initiatives to HIV/AIDS care in Africa, this study aimed to describe practice models, strategies and challenges to delivering end-of-life care in sub-Saharan Africa. Methods A survey end-of-life care programs was conducted, addressing the domains of service aims and configuration, barriers to pain control, governmental endorsement and strategies, funding, monitoring and evaluation, and research. Both closed and qualitative responses were sought. Results Despite great structural challenges, data from 48 programs in 14 countries with a mean annual funding of US $374,884 demonstrated integrated care delivery across diverse settings. Care was commonly integrated with all advanced disease care (67% and disease stages (65% offering care from diagnosis. The majority (98% provided home-based care for a mean of 301 patients. Ninety-four percent reported challenges in pain control (including availability, lack of trained providers, stigma and legal restrictions, and 77% addressed the effects of poverty on disease progression and management. Although 85% of programs reported Government endorsement, end-of-life and palliative care National strategies were largely absent. Conclusions The interdependent tasks of expanding pain control, balancing quality and coverage of care, providing technical assistance in monitoring and evaluation, collaborating between donor agencies and governments, and educating policy makers and program directors of end-of-life care are all necessary if resources are to reach their goals.

  15. Analysis of proton-induced fragment production cross sections by the Quantum Molecular Dynamics plus Statistical Decay Model

    Energy Technology Data Exchange (ETDEWEB)

    Chiba, Satoshi; Iwamoto, Osamu; Fukahori, Tokio; Niita, Koji; Maruyama, Toshiki; Maruyama, Tomoyuki; Iwamoto, Akira [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-03-01

    The production cross sections of various fragments from proton-induced reactions on {sup 56}Fe and {sup 27}Al have been analyzed by the Quantum Molecular Dynamics (QMD) plus Statistical Decay Model (SDM). It was found that the mass and charge distributions calculated with and without the statistical decay have very different shapes. These results also depend strongly on the impact parameter, showing an importance of the dynamical treatment as realized by the QMD approach. The calculated results were compared with experimental data in the energy region from 50 MeV to 5 GeV. The QMD+SDM calculation could reproduce the production cross sections of the light clusters and intermediate-mass to heavy fragments in a good accuracy. The production cross section of {sup 7}Be was, however, underpredicted by approximately 2 orders of magnitude, showing the necessity of another reaction mechanism not taken into account in the present model. (author)

  16. Triple-humped fission barrier model for a new 238U neutron cross-section evaluation and first validations

    International Nuclear Information System (INIS)

    Lopez Jimenez, M.J.; Morillon, B.; Romain, P.

    2005-01-01

    A new neutron-induced cross-section evaluation of 238 U from 1 keV up to 200 MeV has been performed using only nuclear reactions models. A new fission penetrability model taking into account a triple humped barrier has been developed. A clear improvement has been observed for K-effective validation tests (up to 30 MeV) with this new evaluation. This improvement is mainly due to a better treatment of the inelastic exit channel

  17. Standardizing an End-to-end Accounting Service

    Science.gov (United States)

    Greenberg, Edward; Kazz, Greg

    2006-01-01

    Currently there are no space system standards available for space agencies to accomplish end-to-end accounting. Such a standard does not exist for spacecraft operations nor for tracing the relationship between the mission planning activities, the command sequences designed to perform those activities, the commands formulated to initiate those activities and the mission data and specifically the mission data products created by those activities. In order for space agencies to cross-support one another for data accountability/data tracing and for inter agency spacecraft to interoperate with each other, an international CCSDS standard for end-to-end data accountability/tracing needs to be developed. We will first describe the end-to-end accounting service model and functionality that supports the service. This model will describe how science plans that are ultimately transformed into commands can be associated with the telemetry products generated as a result of their execution. Moreover, the interaction between end-to-end accounting and service management will be explored. Finally, we will show how the standard end-to-end accounting service can be applied to a real life flight project i.e., the Mars Reconnaissance Orbiter project.

  18. Hydrochemical assessment of freshening saline groundwater using multiple end-members mixing modeling: A study of Red River delta aquifer, Vietnam

    Science.gov (United States)

    Kim, Ji-Hyun; Kim, Kyoung-Ho; Thao, Nguyen Thi; Batsaikhan, Bayartungalag; Yun, Seong-Taek

    2017-06-01

    In this study, we evaluated the water quality status (especially, salinity problems) and hydrogeochemical processes of an alluvial aquifer in a floodplain of the Red River delta, Vietnam, based on the hydrochemical and isotopic data of groundwater samples (n = 23) from the Kien Xuong district of the Thai Binh province. Following the historical inundation by paleo-seawater during coastal progradation, the aquifer has been undergone progressive freshening and land reclamation to enable settlements and farming. The hydrochemical data of water samples showed a broad hydrochemical change, from Na-Cl through Na-HCO3 to Ca-HCO3 types, suggesting that groundwater was overall evolved through the freshening process accompanying cation exchange. The principal component analysis (PCA) of the hydrochemical data indicates the occurrence of three major hydrogeochemical processes occurring in an aquifer, namely: 1) progressive freshening of remaining paleo-seawater, 2) water-rock interaction (i.e., dissolution of silicates), and 3) redox process including sulfate reduction, as indicated by heavy sulfur and oxygen isotope compositions of sulfate. To quantitatively assess the hydrogeochemical processes, the end-member mixing analysis (EMMA) and the forward mixing modeling using PHREEQC code were conducted. The EMMA results show that the hydrochemical model with the two-dimensional mixing space composed of PC 1 and PC 2 best explains the mixing in the study area; therefore, we consider that the groundwater chemistry mainly evolved by mixing among three end-members (i.e., paleo-seawater, infiltrating rain, and the K-rich groundwater). The distinct depletion of sulfate in groundwater, likely due to bacterial sulfate reduction, can also be explained by EMMA. The evaluation of mass balances using geochemical modeling supports the explanation that the freshening process accompanying direct cation exchange occurs through mixing among three end-members involving the K-rich groundwater. This

  19. Numerical and analytical modeling of the end-loaded split (ELS) test specimens made of multi-directional coupled composite laminates

    Science.gov (United States)

    Samborski, Sylwester; Valvo, Paolo S.

    2018-01-01

    The paper deals with the numerical and analytical modelling of the end-loaded split test for multi-directional laminates affected by the typical elastic couplings. Numerical analysis of three-dimensional finite element models was performed with the Abaqus software exploiting the virtual crack closure technique (VCCT). The results show possible asymmetries in the widthwise deflections of the specimen, as well as in the strain energy release rate (SERR) distributions along the delamination front. Analytical modelling based on a beam-theory approach was also conducted in simpler cases, where only bending-extension coupling is present, but no out-of-plane effects. The analytical results matched the numerical ones, thus demonstrating that the analytical models are feasible for test design and experimental data reduction.

  20. Model inverse calculation of current distributions in the cross-section of a superconducting cable

    International Nuclear Information System (INIS)

    Usak, P.; Sastry, P.V.P.S.S.; Schwartz, J.

    2006-01-01

    The solution of an inverse problem for magnetic field mapping, and the related current distribution in the cross-section of a superconducting cable are generally not unique. Nevertheless, for many natural configurations of a transport current distribution in the cross-section of a superconducting cable, the resulting magnetic field can be used for the reconstruction of a current distribution even in the presence of noise to a degree. We show it using several examples. To perform the inverse calculation, the Tichonov method of regularization was successfully applied. The approach was applied for superconducting cables, but its application is general

  1. [Predictive value of pediatrics end-stage liver disease or model for end-stage liver disease score in the prognosis of pediatric acute liver failure treated with artificial liver support system].

    Science.gov (United States)

    Jinhao, Tao; Weiming, Chen; Jing, Hu; Jun, He; Jian, Ma; Peng, Shi; Zhujin, Lu; Guoping, Lu; Yimin, Zhu

    2015-04-01

    To investigate the predictive value of pediatrics end-stage liver disease (PELD) or the model for end-stage liver disease (MELD) in the prognosis of pediatric acute liver failure (PALF) treated with artificial liver support system (ALSS). The clinical data of 47 children with acute liver failure seen from August 2008 to July 2013 treated in Children's Hospital, Fudan University were analyzed. Thirty children were treated with ALSS in addition to conventional comprehensive medical treatment (ALSS group). Seventeen children were treated with only conventional comprehensive medical treatment (control group). The main biochemical parameters and coagulation function parameters before and after treatment were compared in the ALSS group and the mortality rates were compared between the two groups. The patients were graded by PELD or MELD when they were hospitalized and the relationship of PELD or MELD scores and mortalities of child patients with the receiver operating characteristic curve (ROC) were analyzed. There were significant differences in total bilirubin (TB) ((302 ± 208) vs. (161 ± 129) µmol/L); alanine aminotransferase (ALT) ((161 ± 225) vs. (761 ± 834) U/L); aspartate aminotransferase ( AST) (66 (35, 123 ) vs. 447 (184, 1,129 ) U/L) ; international normalized ratio (INR) ((2.6 ± 1.6) vs. (5.1 ± 4.0)); prothrombin time activity percentage (PTA) ((42 ± 25)% vs. (22 ± 13)%); albumin( ALB) ((35 ± 5) vs. (33 ± 6) g/L) in the ALSS group after treatment. Through the ROC curve analysis, the best PELD/MELD threshold was 25 to predict the patients survival after ALSS therapy, with a sensitivity of 92. 3% , and a specificity of 94.1% at the cutoff point. The area under the ROC curve was 0. 912. The mortality of patients with PELD or MELD score below 25 in the ALSS group (1/13) was lower than the control group (3/4) (P = 0.022), and the mortality of patients with PELD or MELD score over 25 (16/17) was higher than that of the control group (10/13) (P = 0

  2. A local-community-level, physically-based model of end-use energy consumption by Australian housing stock

    International Nuclear Information System (INIS)

    Ren Zhengen; Paevere, Phillip; McNamara, Cheryl

    2012-01-01

    We developed a physics based bottom-up model to estimate annual housing stock energy consumption at a local community level (Census Collection District—CCD) with an hourly resolution. Total energy consumption, including space heating and cooling, water heating, lighting and other household appliances, was simulated by considering building construction and materials, equipment and appliances, local climates and occupancy patterns. The model was used to analyse energy use by private dwellings in more than five thousand CCDs in the state of New South Wales (NSW), Australia. The predicted results focus on electricity consumption (natural gas and other fuel sources were excluded as the data are not available) and track the actual electricity consumption at CCD level with an error of 9.2% when summed to state level. For NSW and Victoria 2006, the predicted state electricity consumption is close to the published model (within 6%) and statistical data (within 10%). A key feature of the model is that it can be used to predict hourly electricity consumption and peak demand at fine geographic scales, which is important for grid planning and designing local energy efficiency or demand response strategies. - Highlights: ► We developed a physics-based model to estimate housing stock energy consumption. ► House type and vintage, family type and occupancy time were considered. ► The model results are close to actual energy consumption at local community level. ► Its’ results agree well with the published model and statistical data at state level. ► It shows the model could provide from hourly to annual residential energy consumption.

  3. THE NON-UNIVERSALITY OF THE LOW-MASS END OF THE IMF IS ROBUST AGAINST THE CHOICE OF SSP MODEL

    International Nuclear Information System (INIS)

    Spiniello, C.; Trager, S. C.; Koopmans, L. V. E.

    2015-01-01

    We perform a direct comparison of two state-of-the art single stellar population (SSP) models that have been used to demonstrate the non-universality of the low-mass end of the initial mass function (IMF) slope. The two public versions of the SSP models are restricted to either solar abundance patterns or solar metallicity, too restrictive if one aims to disentangle elemental enhancements, metallicity changes, and IMF variations in massive early-type galaxies (ETGs) with star formation histories different from those in the solar neighborhood. We define response functions (to metallicity and α-abundance) to extend the parameter space for each set of models. We compare these extended models with a sample of Sloan Digital Sky Survey (SDSS) ETG spectra with varying velocity dispersions. We measure equivalent widths of optical IMF-sensitive stellar features to examine the effect of the underlying model assumptions and ingredients, such as stellar libraries or isochrones, on the inference of the IMF slope down to ∼0.1 M ⊙ . We demonstrate that the steepening of the low-mass end of the IMF based on a non-degenerate set of spectroscopic optical indicators is robust against the choice of the stellar population model. Although the models agree in a relative sense (i.e., both imply more bottom-heavy IMFs for more massive systems), we find non-negligible differences in the absolute values of the IMF slope inferred at each velocity dispersion by using the two different models. In particular, we find large inconsistencies in the quantitative predictions of the IMF slope variations and abundance patterns when sodium lines are used. We investigate the possible reasons for these inconsistencies

  4. Variation of pressure from cervical to distal end of oesophagus during swallowing: Study of a mathematical model.

    Science.gov (United States)

    Pandey, Sanjay Kumar; Ranjan, Gireesh; Tiwari, Shailendra Kumar; Pandey, Kushagra

    2017-06-01

    The investigation is an attempt to explore the cause that generates high pressure in the distal oesophagus compared to that in the proximal part. We observe through computer simulation that peristaltic waves of even slightly but progressively increasing amplitude can generate high pressure near the distal end. This is illustrated through exponential growth in the wave amplitude, which represents the dependence of the rate of growth of amplitude on its current magnitude. This may be physically interpreted that the generation of high pressure in the lower oesophagus ensures complete bolus delivery to the stomach through the cardiac sphincter. This finding may prove to be a very prominent result towards creating a prosthetic oesophagus. Some more conclusions with regard to progressive exponential increase in amplitude are also drawn. The pressure falls to zero invariably in the proximal half of every bolus, whereas for constant amplitude, zero pressure is located exactly at the midpoints of the boluses for Newtonian flows. Backward flow of fluid takes place in a smaller region if amplitude increases. Circular muscles contract more in the lower oesophagus to generate higher pressure in the distal oesophagus. In a sharp contrast to the case of constant-amplitude, pressure is neither uniformly distributed in a wave, nor is of identical shape for all boluses in the case of train wave propagation. Pressure distribution along the axis of the oesophagus differs in shape and magnitude both when a single wave propagates. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Propagation of pitting corrosion of steel in concrete: conceptual models for local cross section loss

    NARCIS (Netherlands)

    Polder, R.B.; Angst, U.M.; Pacheco, J.; Peelen, W.H.A.

    2016-01-01

    Where exposed to an aggressive environment, concrete structures will develop reinforcement corrosion at some point in their life. Chloride ions from de-icing salt or sea water induce pitting corrosion. Local cross section reduction may occur relatively quickly and expansion due to corrosion products

  6. Preliminary assessment of Geant4 HP models and cross section libraries by reactor criticality benchmark calculations

    DEFF Research Database (Denmark)

    Cai, Xiao-Xiao; Llamas-Jansa, Isabel; Mullet, Steven

    2013-01-01

    , U and O in uranium dioxide, Al metal, Be metal, and Fe metal. The native HP cross section library G4NDL does not include data for elements with atomic number larger than 92. Therefore, transuranic elements, which have impacts for a realistic reactor, can not be simulated by the combination of the HP...

  7. Models of cosmic ray sources: the possible role of the ionization cross section

    International Nuclear Information System (INIS)

    Arnaud, M.; Rothenflug, R.; Casse, M.

    1987-01-01

    We confirm that a clear correlation exists between the Cosmic Ray Source/Local Galactic abundance ratio and the ionization cross section of the corresponding neutral elements, as pointed out originally by Krisstianson in 1971. However we are not able to propose a firm explanation to this empirical fact

  8. Shell-model computed cross sections for charged-current scattering of astrophysical neutrinos off 40Ar

    Science.gov (United States)

    Kostensalo, Joel; Suhonen, Jouni; Zuber, K.

    2018-03-01

    Charged-current (anti)neutrino-40Ar cross sections for astrophysical neutrinos have been calculated. The initial and final nuclear states were calculated using the nuclear shell model. The folded solar-neutrino scattering cross section was found to be 1.78 (23 ) ×10-42cm2 , which is higher than what the previous papers have reported. The contributions from the 1- and 2- multipoles were found to be significant at supernova-neutrino energies, confirming the random-phase approximation (RPA) result of a previous study. The effects of neutrino flavor conversions in dense stellar matter (matter oscillations) were found to enhance the neutrino-scattering cross sections significantly for both the normal and inverted mass hierarchies. For the antineutrino scattering, only a small difference between the nonoscillating and inverted-hierarchy cross sections was found, while the normal-hierarchy cross section was 2-3 times larger than that of the nonoscillating cross section, depending on the adopted parametrization of the Fermi-Dirac distribution. This property of the supernova-antineutrino signal could probably be used to distinguish between the two hierarchies in megaton LAr detectors.

  9. The end of cheap oil: Bottom-up economic and geologic modeling of aggregate oil production curves

    International Nuclear Information System (INIS)

    Jakobsson, Kristofer; Bentley, Roger; Söderbergh, Bengt; Aleklett, Kjell

    2012-01-01

    There is a lively debate between ‘concerned’ and ‘unconcerned’ analysts regarding the future availability and affordability of oil. We critically examine two interrelated and seemingly plausible arguments for an unconcerned view: (1) there is a growing amount of remaining reserves; (2) there is a large amount of oil with a relatively low average production cost. These statements are unconvincing on both theoretical and empirical grounds. Oil availability is about flows rather than stocks, and average cost is not relevant in the determination of price and output. We subsequently implement a bottom-up model of regional oil production with micro-foundations in both natural science and economics. An oil producer optimizes net present value under the constraints of reservoir dynamics, technological capacity and economic circumstances. Optimal production profiles for different reservoir drives and economic scenarios are derived. The field model is then combined with a discovery model of random sampling from a lognormal field size-frequency distribution. Regional discovery and production scenarios are generated. Our approach does not rely on the simple assumptions of top-down models such as the Hubbert curve – however it leads to the same qualitative result that production peaks when a substantial fraction of the recoverable resource remains in-ground. - Highlights: ► Remaining oil reserves and average costs are of limited use in forecasting. ► We present a bottom-up approach to the modeling of regional oil production. ► Producers maximize net present value under technological and physical constraints. ► Exploration is modeled as random sampling from a lognormal field size distribution. ► Regional production starts declining before half of the recoverable oil is produced.

  10. Value-Focused Thinking Model to Evaluate SHM System Alternatives From Military end User Requirements Point of View

    Directory of Open Access Journals (Sweden)

    Klimaszewski Sławomir

    2016-12-01

    Full Text Available The article describes Value-Focused Thinking (VFT model developed in order to evaluate various alternatives for implementation of Structural Health Monitoring (SHM system on a military aircraft. Four SHM system alternatives are considered based on: visual inspection (current approach, piezoelectric (PZT sensors, Fiber Bragg Grating (FBG sensors and Comparative Vacuum Monitoring (CVM sensors. A numerical example is shown to illustrate the model capability. Sensitivity analyses are performed on values such as Cost, Performance, Aircraft Availability and Technology Readiness Level in order to examine influence of these values on overall value of structural state of awareness provided by particular SHM system alternative.

  11. Correspondence between theoretical models and dual energy x-ray absorptiometry measurements of femoral cross-sectional growth during adolescence

    Science.gov (United States)

    van der Meulen, M. C.; Marcus, R.; Bachrach, L. K.; Carter, D. R.

    1997-01-01

    We have developed an analytical model of long bone cross-sectional ontogeny in which appositional growth of the diaphysis is primarily driven by mechanical stimuli associated with increasing body mass during growth and development. In this study, our goal was to compare theoretical predictions of femoral diaphyseal structure from this model with measurements of femoral bone mineral and geometry by dual energy x-ray absorptiometry. Measurements of mid-diaphyseal femoral geometry and structure were made previously in 101 Caucasian adolescents and young adults 9-26 years of age. The data on measured bone mineral content and calculated section modulus were compared with the results of our analytical model of cross-sectional development of the human femur over the same age range. Both bone mineral content and section modulus showed good correspondence with experimental measurements when the relationships with age and body mass were examined. Strong linear relationships were evident for both parameters when examined as a function of body mass.

  12. Correlation of end tidal carbon dioxide, amplitude spectrum area, and coronary perfusion pressure in a porcine model of cardiac arrest.

    Science.gov (United States)

    Segal, Nicolas; Metzger, Anja K; Moore, Johanna C; India, Laura; Lick, Michael C; Berger, Paul S; Tang, Wanchun; Benditt, David G; Lurie, Keith G

    2017-09-01

    Amplitude Spectrum Area (AMSA) values during ventricular fibrillation (VF) correlate with myocardial energy stores and predict defibrillation success. By contrast, end tidal CO 2 (ETCO2) values provide a noninvasive assessment of coronary perfusion pressure and myocardial perfusion during cardiopulmonary resuscitation (CPR). Given the importance of the timing of defibrillation shock delivery on clinical outcome, we tested the hypothesis that AMSA and ETCO2 correlate with each other and can be used interchangably to correlate with myocardial perfusion in an animal laboratory preclinical, randomized, prospective investigation. After 6 min of untreated VF, 12 female pigs (32 ± 1 Kg), isoflurane anesthetized pigs received sequentially 3 min periods of standard (S) CPR, S-CPR+ an impedance threshold device (ITD), and then active compression decompression (ACD) + ITD CPR Hemodynamic, AMSA, and ETCO2 measurements were made with each method of CPR The Spearman correlation and Friedman tests were used to compare hemodynamic parameters. ETCO2, AMSA, coronary perfusion pressure, cerebral perfusion pressure were lowest with STD CPR, increased with STD CPR + ITD and highest with ACD CPR + ITD Further analysis demonstrated a positive correlation between AMSA and ETCO2 ( r  = 0.37, P  = 0.025) and between AMSA and key hemodynamic parameters ( P  < 0.05). This study established a moderate positive correlation between ETCO2 and AMSA These findings provide the physiological basis for developing and testing a novel noninvasive method that utilizes either ETCO2 alone or the combination of ETCO2 and AMSA to predict when defibrillation might be successful. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  13. Modelling End-User of Electronic-Government Service: The Role of Information quality, System Quality and Trust

    Science.gov (United States)

    Witarsyah Jacob, Deden; Fudzee, Mohd Farhan Md; Aizi Salamat, Mohamad; Kasim, Shahreen; Mahdin, Hairulnizam; Azhar Ramli, Azizul

    2017-08-01

    Many governments around the world increasingly use internet technologies such as electronic government to provide public services. These services range from providing the most basic informational website to deploying sophisticated tools for managing interactions between government agencies and beyond government. Electronic government (e-government) aims to provide a more accurate, easily accessible, cost-effective and time saving for the community. In this study, we develop a new model of e-government adoption service by extending the Unified Theory of Acceptance and Use of Technology (UTAUT) through the incorporation of some variables such as System Quality, Information Quality and Trust. The model is then tested using a large-scale, multi-site survey research of 237 Indonesian citizens. This model will be validated by using Structural Equation Modeling (SEM). The result indicates that System Quality, Information Quality and Trust variables proven to effect user behavior. This study extends the current understanding on the influence of System Quality, Information Quality and Trust factors to researchers, practitioners, and policy makers.

  14. Linear Modeling of the Three-Phase Diode Front-Ends with Reduced Capacitance Considering the Continuous Conduction Mode

    DEFF Research Database (Denmark)

    Máthé, Lászlo; Yang, Feng; Wang, Dong

    2016-01-01

    for the entire drive systems have to be designed. A linearization and simplification to single phase model can be performed; however, when inductance is present at the grid side its performance is not satisfactory. The problem is mainly caused by neglecting the continuous conduction mode of the rectifier...

  15. Modeling of a Membrane Based Humidifier for Fuel Cell Applications Subject to End-Of-Life Conditions

    DEFF Research Database (Denmark)

    Nielsen, Mads Pagh; Olesen, Anders Christian; Menard, Alan

    2014-01-01

    -based water permeable membrane. Results are presented at nominal BOL-conditions and extreme EOL-conditions. A detailed sub-model incorporating the water absorption/desorption kinetics of Nafion and a novel and accurate representation of the diffusion coefficient of water in Nafion was implemented...

  16. Measurement of the Standard Model W+W- production cross-section using the ATLAS experiment on the LHC

    International Nuclear Information System (INIS)

    Zeman, Martin

    2014-01-01

    Measurements of di-boson production cross-sections are an important part of the physics programme at the CERN Large Hadron Collider. These physics analyses provide the opportunity to probe the electroweak sector of the Standard Model at the TeV scale and could also indicate the existence of new particles or probe beyond the Standard Model physics. The excellent performance of the LHC through years 2011 and 2012 allowed for very competitive measurements. This thesis provides a comprehensive overview of the experimental considerations and methods used in the measurement of the W + W - production cross-section in proton-proton collisions at √s = 7 TeV and 8 TeV. The treatise covers the material in great detail, starting with the introduction of the theoretical framework of the Standard Model and follows with an extensive discussion of the methods implemented in recording and reconstructing physics events in an experiment of this magnitude. The associated online and offline software tools are included in the discussion. The relevant experiments are covered, including a very detailed section about the ATLAS detector. The final chapter of this thesis contains a detailed description of the analysis of the W-pair production in the leptonic decay channels using the datasets recorded by the ATLAS experiment during 2011 and 2012 (Run I). The analyses use 4.60 fb -1 recorded at √s = 7 TeV and 20.28 fb -1 recorded at 8 TeV. The experimentally measured cross section for the production of W bosons at the ATLAS experiment is consistently enhanced compared to the predictions of the Standard Model at centre-of-mass energies of 7 TeV and 8 TeV. The thesis concludes with the presentation of differential cross-section measurement results. (author) [fr

  17. GNASH: a preequilibrium, statistical nuclear-model code for calculation of cross sections and emission spectra

    International Nuclear Information System (INIS)

    Young, P.G.; Arthur, E.D.

    1977-11-01

    A new multistep Hauser--Feshbach code that includes corrections for preequilibrium effects is described. The code can calculate up to 60 decay reactions (cross sections and energy spectra) in one computation, and thereby provide considerable flexibility for handling processes with complicated reaction chains. Input parameter setup, problem output, and subroutine descriptions are given along with a sample problem calculation. A brief theoretical description is also included. 8 figures, 3 tables

  18. Nursing Care Model Based on Knowledge Management in Preventing Nosocomial Infection After Caesarean Section in Hospital

    OpenAIRE

    Ahsan Ahsan

    2016-01-01

    Introduction: Nosocomial infection is one indicator of the quality of health services in the community, which also determines the image of health care institutions becauseit was a major cause of morbidityand death rate (mortality) in hospital. Nursing care based on knowledge management is established from identification knowledge which is required, prevention performance of nosocomial infections post section caesarea. Nosocomial infections component consists of wound culture result. Method: T...

  19. The thin section rock physics: Modeling and measurement of seismic wave velocity on the slice of carbonates

    Energy Technology Data Exchange (ETDEWEB)

    Wardaya, P. D., E-mail: pongga.wardaya@utp.edu.my; Noh, K. A. B. M., E-mail: pongga.wardaya@utp.edu.my; Yusoff, W. I. B. W., E-mail: pongga.wardaya@utp.edu.my [Petroleum Geosciences Department, Universiti Teknologi PETRONAS, Tronoh, Perak, 31750 (Malaysia); Ridha, S. [Petroleum Engineering Department, Universiti Teknologi PETRONAS, Tronoh, Perak, 31750 (Malaysia); Nurhandoko, B. E. B. [Wave Inversion and Subsurface Fluid Imaging Research Laboratory (WISFIR), Dept. of Physics, Institute of Technology Bandung, Bandung, Indonesia and Rock Fluid Imaging Lab, Bandung (Indonesia)

    2014-09-25

    This paper discusses a new approach for investigating the seismic wave velocity of rock, specifically carbonates, as affected by their pore structures. While the conventional routine of seismic velocity measurement highly depends on the extensive laboratory experiment, the proposed approach utilizes the digital rock physics view which lies on the numerical experiment. Thus, instead of using core sample, we use the thin section image of carbonate rock to measure the effective seismic wave velocity when travelling on it. In the numerical experiment, thin section images act as the medium on which wave propagation will be simulated. For the modeling, an advanced technique based on artificial neural network was employed for building the velocity and density profile, replacing image's RGB pixel value with the seismic velocity and density of each rock constituent. Then, ultrasonic wave was simulated to propagate in the thin section image by using finite difference time domain method, based on assumption of an acoustic-isotropic medium. Effective velocities were drawn from the recorded signal and being compared to the velocity modeling from Wyllie time average model and Kuster-Toksoz rock physics model. To perform the modeling, image analysis routines were undertaken for quantifying the pore aspect ratio that is assumed to represent the rocks pore structure. In addition, porosity and mineral fraction required for velocity modeling were also quantified by using integrated neural network and image analysis technique. It was found that the Kuster-Toksoz gives the closer prediction to the measured velocity as compared to the Wyllie time average model. We also conclude that Wyllie time average that does not incorporate the pore structure parameter deviates significantly for samples having more than 40% porosity. Utilizing this approach we found a good agreement between numerical experiment and theoretically derived rock physics model for estimating the effective seismic

  20. The thin section rock physics: Modeling and measurement of seismic wave velocity on the slice of carbonates

    International Nuclear Information System (INIS)

    Wardaya, P. D.; Noh, K. A. B. M.; Yusoff, W. I. B. W.; Ridha, S.; Nurhandoko, B. E. B.

    2014-01-01

    This paper discusses a new approach for investigating the seismic wave velocity of rock, specifically carbonates, as affected by their pore structures. While the conventional routine of seismic velocity measurement highly depends on the extensive laboratory experiment, the proposed approach utilizes the digital rock physics view which lies on the numerical experiment. Thus, instead of using core sample, we use the thin section image of carbonate rock to measure the effective seismic wave velocity when travelling on it. In the numerical experiment, thin section images act as the medium on which wave propagation will be simulated. For the modeling, an advanced technique based on artificial neural network was employed for building the velocity and density profile, replacing image's RGB pixel value with the seismic velocity and density of each rock constituent. Then, ultrasonic wave was simulated to propagate in the thin section image by using finite difference time domain method, based on assumption of an acoustic-isotropic medium. Effective velocities were drawn from the recorded signal and being compared to the velocity modeling from Wyllie time average model and Kuster-Toksoz rock physics model. To perform the modeling, image analysis routines were undertaken for quantifying the pore aspect ratio that is assumed to represent the rocks pore structure. In addition, porosity and mineral fraction required for velocity modeling were also quantified by using integrated neural network and image analysis technique. It was found that the Kuster-Toksoz gives the closer prediction to the measured velocity as compared to the Wyllie time average model. We also conclude that Wyllie time average that does not incorporate the pore structure parameter deviates significantly for samples having more than 40% porosity. Utilizing this approach we found a good agreement between numerical experiment and theoretically derived rock physics model for estimating the effective seismic wave

  1. Methodology to carry out a sensitivity and uncertainty analysis for cross sections using a coupled model Trace-Parcs

    International Nuclear Information System (INIS)

    Reyes F, M. C.; Del Valle G, E.; Gomez T, A. M.; Sanchez E, V.

    2015-09-01

    A methodology was implemented to carry out a sensitivity and uncertainty analysis for cross sections used in a coupled model for Trace/Parcs in a transient of control rod fall of a BWR-5. A model of the reactor core for the neutronic code Parcs was used, in which the assemblies located in the core are described. Thermo-hydraulic model in Trace was a simple model, where only a component type Chan was designed to represent all the core assemblies, which it was within a single vessel and boundary conditions were established. The thermo-hydraulic part was coupled with the neutron part, first for the steady state and then a transient of control rod fall was carried out for the sensitivity and uncertainty analysis. To carry out the analysis of cross sections used in the coupled model Trace/Parcs during the transient, the Probability Density Functions for 22 parameters selected from the total of neutronic parameters that use Parcs were generated, obtaining 100 different cases for the coupled model Trace/Parcs, each one with a database of different cross sections. All these cases were executed with the coupled model, obtaining in consequence 100 different output files for the transient of control rod fall doing emphasis in the nominal power, for which an uncertainty analysis was realized at the same time generate the band of uncertainty. With this analysis is possible to observe the ranges of results of the elected responses varying the selected uncertainty parameters. The sensitivity analysis complements the uncertainty analysis, identifying the parameter or parameters with more influence on the results and thus focuses on these parameters in order to better understand their effects. Beyond the obtained results, because is not a model with real operation data, the importance of this work is to know the application of the methodology to carry out the sensitivity and uncertainty analyses. (Author)

  2. Estimation of unemployment rates using small area estimation model by combining time series and cross-sectional data

    Science.gov (United States)

    Muchlisoh, Siti; Kurnia, Anang; Notodiputro, Khairil Anwar; Mangku, I. Wayan

    2016-02-01

    Labor force surveys conducted over time by the rotating panel design have been carried out in many countries, including Indonesia. Labor force survey in Indonesia is regularly conducted by Statistics Indonesia (Badan Pusat Statistik-BPS) and has been known as the National Labor Force Survey (Sakernas). The main purpose of Sakernas is to obtain information about unemployment rates and its changes over time. Sakernas is a quarterly survey. The quarterly survey is designed only for estimating the parameters at the provincial level. The quarterly unemployment rate published by BPS (official statistics) is calculated based on only cross-sectional methods, despite the fact that the data is collected under rotating panel design. The study purpose to estimate a quarterly unemployment rate at the district level used small area estimation (SAE) model by combining time series and cross-sectional data. The study focused on the application and comparison between the Rao-Yu model and dynamic model in context estimating the unemployment rate based on a rotating panel survey. The goodness of fit of both models was almost similar. Both models produced an almost similar estimation and better than direct estimation, but the dynamic model was more capable than the Rao-Yu model to capture a heterogeneity across area, although it was reduced over time.

  3. Identification and implementation of end-user needs during development of a state-of-the-art modeling tool-set - 59069

    International Nuclear Information System (INIS)

    Seitz, Roger; Williamson, Mark; Gerdes, Kurt; Freshley, Mark; Dixon, Paul; Collazo, Yvette T.; Hubbard, Susan

    2012-01-01

    The U.S. Department of Energy (US DOE) Office of Environmental Management, Technology Innovation and Development is supporting a multi-National Laboratory effort to develop the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is an emerging state-of-the-art scientific approach and software infrastructure for understanding and predicting contaminant fate and transport in natural and engineered systems. These modular and open-source high performance computing tools and user interfaces will facilitate integrated approaches that enable standardized assessments of performance and risk for EM cleanup and closure decisions. The ASCEM team recognized that engaging end-users in the ASCEM development process would lead to enhanced development and implementation of the ASCEM tool-sets in the user community. End-user involvement in ASCEM covers a broad spectrum of perspectives, including: performance assessment (PA) and risk assessment practitioners, research scientists, decision-makers, oversight personnel, and regulators engaged in the US DOE cleanup mission. End-users are primarily engaged in ASCEM via the ASCEM User Steering Committee (USC) and the 'user needs interface' task. Future plans also include user involvement in demonstrations of the ASCEM tools. This paper will describe the details of how end users have been engaged in the ASCEM program and will demonstrate how this involvement has strengthened both the tool development and community confidence. ASCEM tools requested by end-users specifically target modeling challenges associated with US DOE cleanup activities. The demonstration activities involve application of ASCEM tools and capabilities to representative problems at DOE sites. Selected results from the ASCEM Phase 1 demonstrations are discussed to illustrate how capabilities requested by end-users were implemented in prototype versions of the ASCEM tool. The ASCEM team engaged a variety of interested parties early in the development

  4. Shortcomings of the Winkler Model in the Assessment of Sectioned Tunnels under Seismic Loading

    DEFF Research Database (Denmark)

    Andersen, Lars; Lyngs, J. H.

    2009-01-01

    A Winkler-type model is often applied in the design of tunnels subject to seismic loading. Since the subgrade stiffness is modelled by disjoint springs, distributed continuously along the tunnel, the model does not account for retroaction via the soil. This may not be a problem in the design of t......-element solution, using a planned tunnel at Thessaloniki, Greece, as a case study. The aim of the analysis is to quantify the inaccuracy of the Winkler model in the prediction of damage at a gasket between two tunnel elements....

  5. External validation and clinical utility of a prediction model for 6-month mortality in patients undergoing hemodialysis for end-stage kidney disease.

    Science.gov (United States)

    Forzley, Brian; Er, Lee; Chiu, Helen Hl; Djurdjev, Ognjenka; Martinusen, Dan; Carson, Rachel C; Hargrove, Gaylene; Levin, Adeera; Karim, Mohamud

    2018-02-01

    End-stage kidney disease is associated with poor prognosis. Health care professionals must be prepared to address end-of-life issues and identify those at high risk for dying. A 6-month mortality prediction model for patients on dialysis derived in the United States is used but has not been externally validated. We aimed to assess the external validity and clinical utility in an independent cohort in Canada. We examined the performance of the published 6-month mortality prediction model, using discrimination, calibration, and decision curve analyses. Data were derived from a cohort of 374 prevalent dialysis patients in two regions of British Columbia, Canada, which included serum albumin, age, peripheral vascular disease, dementia, and answers to the "the surprise question" ("Would I be surprised if this patient died within the next year?"). The observed mortality in the validation cohort was 11.5% at 6 months. The prediction model had reasonable discrimination (c-stat = 0.70) but poor calibration (calibration-in-the-large = -0.53 (95% confidence interval: -0.88, -0.18); calibration slope = 0.57 (95% confidence interval: 0.31, 0.83)) in our data. Decision curve analysis showed the model only has added value in guiding clinical decision in a small range of threshold probabilities: 8%-20%. Despite reasonable discrimination, the prediction model has poor calibration in this external study cohort; thus, it may have limited clinical utility in settings outside of where it was derived. Decision curve analysis clarifies limitations in clinical utility not apparent by receiver operating characteristic curve analysis. This study highlights the importance of external validation of prediction models prior to routine use in clinical practice.

  6. Improving stability of elastic stable intramedullary nailing in a transverse midshaft femur fracture model: biomechanical analysis of using end caps or a third nail.

    Science.gov (United States)

    Rapp, Marion; Gros, Nina; Zachert, Gregor; Schulze-Hessing, Maaike; Stratmann, Christina; Wendlandt, Robert; Kaiser, Martin Michael

    2015-06-25

    Elastic stable intramedullary nailing (ESIN) is accepted widely for treatment of diaphyseal femur fractures in children. However, complication rates of 10 to 50 % are described due to shortening or axial deviation, especially in older or heavier children. Biomechanical in vitro testing was performed to determine whether two modified osteosyntheses with end caps or a third nail could significantly improve the stability in comparison to classical elastic stable intramedullary nailing in a transverse femur fracture model. We performed biomechanical testing in 24 synthetic adolescent femoral bone models (Sawbones®) with a transverse midshaft (diaphyseal) fracture. First, in all models, two nails were inserted in a C-shaped manner (2 × 3.5 mm steel nails, prebent), then eight osteosyntheses were modified by using end caps and another eight by adding a third nail from the antero-lateral (2.5-mm steel, not prebent). Testing was performed in four-point bending, torsion, and shifting under physiological 9° compression. The third nail from the lateral showed a significant positive influence on the stiffness in all four-point bendings as well as in internal rotation comparing to the classical 2C configuration: mean values were significantly higher anterior-posterior (1.04 vs. 0.52 Nm/mm, p < 0.001), posterior-anterior (0.85 vs. 0.43 Nm/mm, p < 0.001), lateral-medial (1.26 vs. 0.70 Nm/mm, p < 0.001), and medial-lateral (1.16 vs. 0.76 Nm/mm, p < 0.001) and during internal rotation (0.16 vs. 0.11 Nm/°, p < 0.001). The modification with end caps did not improve the stiffness in any direction. The configuration with a third nail provided a significantly higher stiffness than the classical 2C configuration as well as the modification with end caps in this biomechanical model. This supports the ongoing transfer of the additional third nail into clinical practice to reduce the axial deviation occurring in clinical practice.

  7. Dissociation cross sections of ground-state and excited charmonia with light mesons in the quark model

    Energy Technology Data Exchange (ETDEWEB)

    T. Barnes; E.S. Swanson; C.-Y. Wong; X.-M. Xu

    2003-07-29

    We present numerical results for the dissociation cross sections of ground-state, orbitally- and radially-excited charmonia in collisions with light mesons. Our results are derived using the nonrelativistic quark model, so all parameters are determined by fits to the experimental meson spectrum. Examples of dissociation into both exclusive and inclusive final states are considered. The dissociation cross sections of several C=(+) charmonia may be of considerable importance for the study of heavy ion collisions, since these states are expected to be produced more copiously than the J/{psi}. The relative importance of the productions of ground-state and orbitally-excited charmed mesons in a pion-charmonium collision is demonstrated through the {radical}s-dependent charmonium dissociation cross sections.

  8. Elementary School Students' Mental Models about Formation of Seasons: A Cross Sectional Study

    Science.gov (United States)

    Türk, Cumhur; Kalkan, Hüseyin; Kiroglu, Kasim; Ocak Iskeleli, Nazan

    2016-01-01

    The purpose of this study is to determine the mental models of elementary school students on seasons and to analyze how these models change in terms of grade levels. The study was conducted with 294 students (5th, 6th, 7th and 8th graders) studying in an elementary school of Turkey's Black Sea Region. Qualitative and quantitative data collection…

  9. New model for burnout prediction in channels of various cross-section

    Energy Technology Data Exchange (ETDEWEB)

    Bobkov, V.P.; Kozina, N.V.; Vinogrado, V.N.; Zyatnina, O.A. [Institute of Physics and Power Engineering, Kaluga (Russian Federation)

    1995-09-01

    The model developed to predict a critical heat flux (CHF) in various channels is presented together with the results of data analysis. A model is the realization of relative method of CHF describing based on the data for round tube and on the system of correction factors. The results of data description presented here are for rectangular and triangular channels, annuli and rod bundles.

  10. The cross-sectional shape of tidal sandbanks: modeling and observations

    NARCIS (Netherlands)

    Roos, Pieter C.; Hulscher, Suzanne J.M.H.; Knaapen, Michiel; van Damme, Rudolf M.J.

    2004-01-01

    To improve our understanding of tidal sandbank dynamics, we have developed a nonlinear morphodynamic model. A crucial property of the model is that it fully resolves the dynamics on the fast (tidal) timescale, allowing for asymmetric tidal flow with an M0, M2, and M4 component. This approach,

  11. 7 CFR 51.1240 - Paper ends.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Paper ends. 51.1240 Section 51.1240 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Standards for Cleaned Virginia Type Peanuts in the Shell Definitions § 51.1240 Paper ends. Paper ends means...

  12. Autoradiography of lyophilized animal sections. Bone density measurement in osteoporosis model rats

    International Nuclear Information System (INIS)

    Fujino, Hideki; Asahara, Nobumitsu; Baba, Shigeo; Kimata, Hideki; Tateishi, Mitsuru; Koide, Takashi

    2008-01-01

    To gain a better understanding on the β-ray radiography of lyophilized animal sections, the bone densities of the osteoporosis rats were measured using a 147 Pm planar radiation source. An imaging plate as a radiation sensor was overlaid on the animal section together with a density calibrator. After exposure, radioactivity recorded on the sensor was quantified using a bio-imaging analyzer. The density calibration curve showed linearity in the wide range with a good correlation coefficient (R 2 ≥0.999). The inter- and intra-plate variability showed CV values less than 3.7%. On the measurement of bone density, bone density differences between the sham group and ovariectomized (OVX) group were statistically significant in the femoral cortical (p=0.001) and trabecular bone (p=0.07), and vertebral trabecular bone (p=0.043). Based on these results, we developed a new and valuable method, which made it possible to measure bone density of axial skeleton of a rat, as an alternative to commonly used methods. (author)

  13. Cosmological model with Einstein - De Sitter metric and closed spatial section

    International Nuclear Information System (INIS)

    Wichoski, U.F.

    1987-03-01

    From the hypotesis that our Galaxy, in an early stage of its evolution, was a quasar, our model expects that images of this stage can still be observed in the sky. Thus, we look in a quasar catalogue for the ones that can possibly be interpreted as images of our Galaxy in that stage, with a view to determine the parameters of the model. (author) [pt

  14. Neutron spectra and cross sections for ice and clathrate generated from the synthetic spectrum and synthetic model for molecular solids

    International Nuclear Information System (INIS)

    Petriw, S; Cantargi, F; Granada, R

    2006-01-01

    We present here a Synthetic Model for Molecular Solids, aimed at the description of the interaction of thermal neutrons with this kind of systems.Simple representations of the molecular dynamical modes are used, in order to produce a fair description of neutron scattering kernels and cross sections with a minimum set of input data. Using those spectra, we have generated thermal libraries for M C N P [es

  15. Physical models of renal malignancies using standard cross-sectional imaging and 3-dimensional printers: a pilot study.

    Science.gov (United States)

    Silberstein, Jonathan L; Maddox, Michael M; Dorsey, Phillip; Feibus, Allison; Thomas, Raju; Lee, Benjamin R

    2014-08-01

    To construct high-fidelity, patient customized, physical, 3-dimensional (3D) models of renal units with enhancing renal lesions identified on cross-sectional imaging, which may aid patients, trainees, and clinicians in their comprehension, characterization, localization, and extirpation of suspicious renal masses. Specialized software was used to import patient's diagnostic computerized tomography cross-sectional imaging into 3D printers and create physical 3D models of renal units with enhancing in situ lesions. Patients and trainees had the opportunity to manipulate the individualized model before surgical resection. Sterolithography additive manufacturing, a technique in which an ultraviolet laser is used to cure a photosensitive resin in sequential horizontally oriented layers, was used to build the models (Medical Modeling Inc., Golden, CO). Normal renal parenchyma was printed with a clear translucent resin, and red translucent resin delineated suspicious lesions. Renal vasculature and the proximal collecting system were printed in some models. We constructed 5 physical models of renal units with suspected malignancies before surgery. All patients successfully underwent partial nephrectomy (4 robotic and 1 open). Average ischemia time was 21 minutes, nephrometry score was 6.8, and all margins were negative. Anecdotally, patients, their families, and trainees consistently stated that the models enhanced their comprehension of the renal tumor in relation to surrounding normal renal parenchyma and hilar structures and improved understanding of the goals of the surgery. Preoperative physical 3D models using available printing techniques can be constructed and may potentially influence both patients' and trainees' understanding of renal malignancies. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Optimization of thrie beam terminal end shoe connection.

    Science.gov (United States)

    2017-04-01

    Terminal thrie end shoes connect nested thrie beams to parapets or other bridge rail structure to provide a robust connectivity between a transition section and a rigid railing section. When connecting terminal end shoe to thrie beam transitions, the...

  17. Experimental techniques and theoretical models for the study of integral 14 MeV neutron cross sections

    International Nuclear Information System (INIS)

    Csikai, J.

    1981-01-01

    Owing to technical reasons, most of the data for fast neutron-induced reactions were measured at 14 MeV and the free parameters in nuclear reaction models have been determined at this energy. The discrepancies between experiment and theory are often due to the unmeasured or unreliable experimental data; therefore, it is important to survey the present techniques used for the measurement of total, elastic, nonelastic and partial nonelastic [(n,xn); (n,x charged); (n,f); (n,γ)] cross sections for 14 MeV neutrons. Systematics in the data as well as theoretical and semi-empirical models are also outlined. (author)

  18. Modelling the beginning and end of a planktonic life stage — the distribution of cod eggs and settled juveniles in the North Sea

    DEFF Research Database (Denmark)

    Höffle, Hannes; Munk, Peter

    2012-01-01

    The North Sea cod stock is close to the southern limit of the species’ range. Therefore, it might be vulnerable to future climate change. Direct as well as indirect effects of climate forcing may have the greatest effects on early life stages. Here we present a study on the distribution of cod...... (Gadus morhua) at the beginning and at the end of the planktonic life stage. The distribution of cod eggs was modelled with generalized additive models (GAMs) for the resence/absence and for the nonzero abundance, using environmental as well as spatial covariates. For comparison, we also examined the egg...... time‐scale. The results showed that the effects of the predicted climate change may be complex and may, even within the same species, be beneficial for one life stage and detrimental for another...

  19. Semi-empirical model for stopping cross sections of p, α and Li ions

    Science.gov (United States)

    Alfaz Uddin, M.; Fazlul Haque, A. K.; Talukder, Tanvir I.; Basak, Arun K.; Saha, Bidhan C.; Malik, Fary B.

    2013-10-01

    Absolute magnitudes of stopping cross sections (SCS) for H+, He2+ and Li3+ in various stopping media with atomic numbers Z 2 = 2 to 100 are calculated using atomic density functions from Dirac-Hartree-Fock-Slater wave functions in the Lindhard-Schraff theory [J. Lindhard, M. Scharff, Kgl. Danske Videnskab. Selskab. Mat. Fys. Medd. 27, 15 (1953)]. The newly proposed formula, characterizing projectile-specific parameters in the incident energy range considered herein, describes satisfactorily the experimental and SRIM-simulated SCS data from low energies, with projectile velocities nearing v = Z 1 v 0 (with Z 1 as the projectile’s atomic number, v 0 = c / 137, the Bohr velocity and c, the speed of light in vacuum), to high energies up to about 2.5 MeV/u.

  20. Social Skill Acquisition Model through Face-to-face Interaction: Local Contingency for Open-ended Development

    Directory of Open Access Journals (Sweden)

    Hamed eMahzoon

    2016-03-01

    Full Text Available Behavior associated with joint attention is among the most important human functionalities for communicating with others. Previous studies indicate that even a robot can learn these behavioral patterns as social skills through interaction with a modeled/real caregiver by contingency evaluation. However, existing mechanisms are too time-consuming, especially for implementation on a real-world interactive robot. Also, they are poor in the acquisition of complex skills. In this paper, we propose a fast mechanism that enables the acquisition of many complex social skills within a short interaction time. The mechanism is realized by the utilization of two significant ideas: evaluating contingency locally, and acquiring social skills by finding synergistic contributions of values in contingencies. A comparison of our proposed mechanism in a simple environment of computer simulation with other mechanisms in terms of speed, accuracy, complexity, and noise resistance confirms the superior performance of our mechanism. Further, experimental results obtained with the proposed mechanism in a more complex computer simulation environment, which more closely resembles a real-world environment, indicate that the mechanism can be applied in real-world interaction between a robot and a human.

  1. Numerical model for surge and swab pressures on wells with cross-section variation

    Energy Technology Data Exchange (ETDEWEB)

    Fedevjcyk, Joao Victor; Junqueira, Silvio Luiz de Mello; Negrao, Cezar Otaviano Ribeiro [UTFPR - Federal University of Technology - Parana - Curitiba, PR (Brazil)], e-mails: silvio@utfpr.edu.br, negrao@utfpr.edu.br

    2010-07-01

    Drilling is one of the most complex steps in petroleum exploration. The process is accomplished by rotating a drill bit to compress the rock formation. During drilling, a fluid is pumped into the well to lubricate and cool down the drill bit, to clean up the well, to avoid the formation fluid influx to the well and also to stabilize the borehole walls. Fluid circulation, however, can be interrupted for maintenance reasons and the drill pipe can be moved to remove the drill bit. The downward or upward movement of the drill pipe displaces the fluid within the well causing either under pressure (swab) or over pressure (surge), respectively. If the pressure at the well bore overcomes the formation fracture pressure, a loss of circulation can take place. On the other way round, the upward movement may reduce the pressure below the pore pressure and an inflow of fluid to the well (kick) can occur. An uncontrolled kick may cause a blowout with serious damages. The transient flow induced by the axial movement of the drill pipe is responsible for the pressure changes at the well bore. Nevertheless, the well bore cross section variation may modify the pressure change within the pipe. In this paper, the effects of diameter variation of the drilling well on the surge and swab pressures are investigated. The equations that represent the phenomenon (mass and momentum conservation) are discretized by the finite volume method. Despite its non-Newtonian properties, the fluid is considered Newtonian in this first work. The drill pipe is considered closed and the flow is assumed as single-phased, one-dimensional, isothermal, laminar, compressible and transient. A sensitivity analysis of the flow parameters is carried out. The cross-section changes cause the reflection of the pressure wave, and consequently pressure oscillations. (author)

  2. Modelo Preditivo para Cesariana com Uso de Fatores de Risco Predictive Model using Risk Factors for Cesarean Section

    Directory of Open Access Journals (Sweden)

    Alfredo de Almeida Cunha

    2002-01-01

    Full Text Available Objetivos: Identificar fatores anteparto relacionados à ocorrência de cesariana. Construir modelo preditivo de cesariana. Pacientes e Métodos: Foram estudados todos os 843 partos assistidos em unidade obstétrica de nível III, no período de junho de 1993 a novembro de 1994.O delineamento do estudo foi de coorte do tipo retrospectivo. O critério de inclusão foi de recém-nascido vivo pesando 1.000 g ou mais. A variável dependente foi cesariana, dicotomizada como presente ou ausente. As variáveis independentes foram os fatores anteparto relacionados à cesariana. Para a construção do modelo foi utilizada a regressão logística. Resultados: O modelo multivariado mostrou risco de cesariana de acordo com as seguintes variáveis independentes: adolescência (idade inferior a 20 anos, odds ratio (OR = 0,396; idade materna igual ou superior a 28 anos, OR = 2,133; antecedente de parto normal, OR = 0,626; antecedente de cesariana OR = 4,576; assistência pré-natal, OR=2,346; apresentação pélvica, OR = 4,174; gemelaridade OR = 14,065; hemorragia da segunda metade da prenhez, OR = 28,189; pré-eclampsia leve, OR = 2,180; pré-eclampsia grave, OR = 16,738; hipertensão arterial crônica, OR = 4,927, e outras intercorrências maternas, OR = 2,012. O modelo matemático mostrou concordância entre a probabilidade prevista e a resposta observada em 82,3%, o que indica sua eficiência. Conclusões: Foram identificados 12 fatores anteparto relacionados à ocorrência de cesariana. Foi possível construir modelo preditivo de cesariana utilizando os fatores de risco anteparto identificados no presente estudo.Purpose: to investigate antepartum factors related to cesarean section and develop a cesarean section predictive model. Methods: the study design was a retrospective cohort which included all the cared 843 deliveries in a third level unit from June 1993 through November 1994. Children with 1,000 g birthweight and above were included. The

  3. Prediction-oriented modeling in business research by means of PLS path modeling : Introduction to a JBR special section

    NARCIS (Netherlands)

    Cepeda Carrion, Gabriel; Henseler, Jörg; Ringle, Christian M.; Roldan, Jose Luis

    2016-01-01

    Under the main theme “prediction-oriented modeling in business research by means of partial least squares path modeling” (PLS), the special issue presents 17 papers. Most contributions include content from presentations at the 2nd International Symposium on Partial Least Squares Path Modeling: The

  4. Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model-end of 1971.

    Science.gov (United States)

    Skipper, H E; Schabel, F M; Trader, M W; Laster, W R; Simpson-Herren, L; Lloyd, H H

    1972-06-01

    Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model have been brought together for comparison with available information on the much used transplanted murine leukemia models and human leukemias and lymphomas. The etiologic agent for "spontaneous" AK lymphoma is an RNA virus present at birth in AKR mice. Lymphoma cells first appear in the thymuses of animals at 5-->12 months of age. The time lapse between the first appearance of viable lymphoma cells in the thymus and clinical diagnosis (eg, with about 10(9) widely disseminated viable plus nonviable lymphoma cells in the host) is about 1 month. Thus, the overall doubling time of lymphoma cells before diagnosis is about 1 day. This estimate is compatible with the doubling time of relatively small numbers of first-passage lymphoma cells, assay data on the rate of repopulation of viable lymphoma cells after therapeutic reduction, and the median intermitotic time of dividing lymphoma cells (ie, 0.6 day). In general, the cytokinetic parameters of advanced spontaneous AK lymphoma cell populations are more like those observed in advanced human leukemias than are those of early L1210 leukemia. This paper presents assay data on the reduction in viable spontaneous AK lymphoma cells after treatment with a variety of agents, and the rate of cell repopulation after cessation of treatment. Extensive therapeutic trial data indicate that cyclophosphamide is presently the most effective single agent against spontaneous AK lymphoma, with arabinosylcytosine or palmO-ara-C a close second. Daunomycin, 5-fluorouracil, the nitrosoureas, vincristine, methotrexate, and dexamethasone provided moderate increases in host survival time. The combination of vincristine plus prednisone was a good remission inducer but the median survival time after cessation of treatment was shorter than that observed for cyclophosphamide or palmO-araC. The best responses observed to date with two-drug combinations appear

  5. Capping protein binding to S100B: implications for the tentacle model for capping the actin filament barbed end.

    Science.gov (United States)

    Wear, Martin A; Cooper, John A

    2004-04-02

    S100B binds tightly to a 12-amino acid peptide derived from heterodimeric capping protein. In native intact capping protein, this sequence is in the C terminus of the alpha-subunit, which is important for capping the actin filament. This C-terminal region is proposed to act as a flexible "tentacle," extending away from the body of capping protein in order to bind actin. To this hypothesis, we analyzed the interaction between S100B and capping protein in solution. The C-terminal 28 amino acids of the alpha-subunit, the proposed tentacle, bound to S100B as a free synthetic peptide or a glutathione S-transferase fusion (K(d) approximately 0.4-1 microm). In contrast, S100B did not bind to whole native capping protein or functionally affect its capping activity. S100B does not bind, with any significant affinity, to the proposed alpha-tentacle sequence of whole native capping protein in solution. In the NMR structure of S100B complexed with the alpha-subunit-derived 12-amino acid peptide, the hydrophobic side of a short alpha-helix in the peptide, containing an important tryptophan residue, contacts S100B. In the x-ray structure of native capping protein, the corresponding sequence of the alpha-subunit C terminus, including Trp(271), interacts closely with the body of the protein. Therefore, our results suggest the alpha-subunit C terminus is not mobile as predicted by the tentacle model. Addition of non-ionic detergent allowed whole capping protein to bind weakly to S100B, indicating that the alpha-subunit C terminus can be mobilized from the surface of the capping protein molecule, presumably by weakening the hydrophobic binding at the contact site.

  6. Development of a finite element model for comparing metal and composite fuselage section drop testing

    NARCIS (Netherlands)

    Gransden, D.I.; Alderliesten, R.C.

    2017-01-01

    Part of the work of AircraftFire, a project investigating the effects of fire and crash on aircraft survivability, is presented. This work compares the effect of changing the material model from metallic to composite on the impact damage and floor acceleration characteristics. First, the metallic

  7. Effect of joining the sectioned implant-supported prosthesis on the peri-implant strain generated in simulated mandibular model

    Directory of Open Access Journals (Sweden)

    Ipsha Singh

    2017-01-01

    Full Text Available Aim: The aim of this study is to evaluate the strain developed in simulated mandibular model before and after the joining of an implant-supported screw-retained prosthesis by different joining techniques, namely, arc welding, laser welding, and soldering. Materials and Methods: A specimen simulating a mandibular edentulous ridge was fabricated in heat-cured acrylic resin. 4-mm holes were drilled in the following tooth positions; 36, 33, 43, 46. Implant analogs were placed in the holes. University of California, Los Angeles, abutment was attached to the implant fixture. Eight strain gauges were attached to the acrylic resin model. Six similar models were made. Implant-supported screw-retained fixed prosthesis was fabricated in nickel-chromium alloy. A load of 400 N was applied on the prosthesis using universal testing machine. Resultant strain was measured in each strain gauge. All the prostheses were sectioned at the area between 36 and 33, 33 and 43, and 43 and 46 using 35 micrometer carborundum disc, and strain was measured in each strain gauge after applying a load of 400 N on the prosthesis. Specimens were joined by arc welding, soldering, and laser welding. After joining, a load of 400 N was applied on each prosthesis and the resultant strain was measured in each strain gauge. Results: Highest mean strain values were recorded before sectioning of the prostheses (889.9 microstrains. Lowest mean strain values were recorded after sectioning the prosthesis and before reuniting it (225.0 microstrains. Conclusions: Sectioning and reuniting the long-span implant prosthesis was found to be a significant factor in influencing the peri-implant strain.

  8. Closing the loop: modelling of heart failure progression from health to end-stage using a meta-analysis of left ventricular pressure-volume loops.

    Science.gov (United States)

    Warriner, David R; Brown, Alistair G; Varma, Susheel; Sheridan, Paul J; Lawford, Patricia; Hose, David R; Al-Mohammad, Abdallah; Shi, Yubing

    2014-01-01

    The American Heart Association (AHA)/American College of Cardiology (ACC) guidelines for the classification of heart failure (HF) are descriptive but lack precise and objective measures which would assist in categorising such patients. Our aim was two fold, firstly to demonstrate quantitatively the progression of HF through each stage using a meta-analysis of existing left ventricular (LV) pressure-volume (PV) loop data and secondly use the LV PV loop data to create stage specific HF models. A literature search yielded 31 papers with PV data, representing over 200 patients in different stages of HF. The raw pressure and volume data were extracted from the papers using a digitising software package and the means were calculated. The data demonstrated that, as HF progressed, stroke volume (SV), ejection fraction (EF%) decreased while LV volumes increased. A 2-element lumped parameter model was employed to model the mean loops and the error was calculated between the loops, demonstrating close fit between the loops. The only parameter that was consistently and statistically different across all the stages was the elastance (Emax). For the first time, the authors have created a visual and quantitative representation of the AHA/ACC stages of LVSD-HF, from normal to end-stage. The study demonstrates that robust, load-independent and reproducible parameters, such as elastance, can be used to categorise and model HF, complementing the existing classification. The modelled PV loops establish previously unknown physiological parameters for each AHA/ACC stage of LVSD-HF, such as LV elastance and highlight that it this parameter alone, in lumped parameter models, that determines the severity of HF. Such information will enable cardiovascular modellers with an interest in HF, to create more accurate models of the heart as it fails.

  9. Closing the loop: modelling of heart failure progression from health to end-stage using a meta-analysis of left ventricular pressure-volume loops.

    Directory of Open Access Journals (Sweden)

    David R Warriner

    Full Text Available INTRODUCTION: The American Heart Association (AHA/American College of Cardiology (ACC guidelines for the classification of heart failure (HF are descriptive but lack precise and objective measures which would assist in categorising such patients. Our aim was two fold, firstly to demonstrate quantitatively the progression of HF through each stage using a meta-analysis of existing left ventricular (LV pressure-volume (PV loop data and secondly use the LV PV loop data to create stage specific HF models. METHODS AND RESULTS: A literature search yielded 31 papers with PV data, representing over 200 patients in different stages of HF. The raw pressure and volume data were extracted from the papers using a digitising software package and the means were calculated. The data demonstrated that, as HF progressed, stroke volume (SV, ejection fraction (EF% decreased while LV volumes increased. A 2-element lumped parameter model was employed to model the mean loops and the error was calculated between the loops, demonstrating close fit between the loops. The only parameter that was consistently and statistically different across all the stages was the elastance (Emax. CONCLUSIONS: For the first time, the authors have created a visual and quantitative representation of the AHA/ACC stages of LVSD-HF, from normal to end-stage. The study demonstrates that robust, load-independent and reproducible parameters, such as elastance, can be used to categorise and model HF, complementing the existing classification. The modelled PV loops establish previously unknown physiological parameters for each AHA/ACC stage of LVSD-HF, such as LV elastance and highlight that it this parameter alone, in lumped parameter models, that determines the severity of HF. Such information will enable cardiovascular modellers with an interest in HF, to create more accurate models of the heart as it fails.

  10. Analytical Model of Inlet Growth and Equilibrium Cross-Sectional Area

    Science.gov (United States)

    2016-04-01

    ERDC/CHL CHETN-IV-107 April 2016 Approved for public release; distribution is unlimited. Analytical Model of Inlet Growth and Equilibrium Cross...encompass a broader range of theoretical alternatives to investigate inlet stability. The quadratic formula provides quantitative estimates of equilibrium ...rework sediment. Escoffier (1940) theorized that stable inlets form when the maximum flow equals an equilibrium value based on sediment transport

  11. A cross-sectional model of eating disorders in Argentinean overweight and obese children.

    Science.gov (United States)

    Elizathe, Luciana Soledad; Arana, Fernán Guido; Rutsztein, Guillermina

    2018-02-01

    Despite the fact that past research identified childhood obesity as an antecedent of eating disorders, not all obese children further develop this pathology. With this regard, our first purpose was to isolate which characteristics differentiate overweight children who have an eating disorder from those who have not. Second, considering that there is little evidence collected in Latin American countries, we provided overweight children data from an Argentinean sample. Specifically, we investigated if weight-teasing, perfectionism, disturbed eating attitudes and behaviors, and body image dissatisfaction are related to the occurrence of an eating disorder in 100 school-aged overweight/obese children (37 girls and 63 boys; mean age 10.85, SD 0.88). Participants completed self-report instruments and were interviewed between 1 and 2 months later to confirm the presence of eating disorders. Seventeen percent participants confirmed to have an eating disorder. Further, the multivariate logistic analysis revealed that perfectionism (Exp β = 1.19) and disturbed eating attitudes and behaviors (Exp β = 4.78) were jointly associated with the presence of an eating disorder. These results were maintained even when the overall model was adjusted for covariates such as age, gender, body mass index, and school type. Weight-teasing and body image dissatisfaction did not contribute to the multivariate model. Prevalence rates of ED and model findings were discussed.

  12. The non-homologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks: I. A mathematical model.

    Science.gov (United States)

    Taleei, Reza; Nikjoo, Hooshang

    2013-05-01

    This article presents a biochemical kinetic model for the non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair pathway. The model is part of a theoretical framework to encompass all cellular DSB repair pathways. The NHEJ model was developed by taking into consideration the biological characteristics of the repair processes in the absence of homologous recombination (HR), the major alternative pathway for DSB repair. The model considers fast and slow components of the repair kinetics resulting in a set of differential equations that were solved numerically. In the absence of available published data for reaction rate constants for the repair proteins involved in NHEJ, we propose reaction rate constants for the solution of the equations. We assume as a first approximation that the reaction rate constants are applicable to mammalian cells under same conditions. The model was tested by comparing measured and simulated DSB repair kinetics obtained with HR-deficient cell lines irradiated by X rays in the dose range of 20-80 Gy. Measured data for initial protein recruitment to a DSB were used to independently estimate rate constants for Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). We show here based on the model of DSB repair described in this article, application of the model in the accompanying article (Taleei et al., Radiat. Res. 179, 540-548, 2013) and by simulation of repair times for each individual DSB produced by individual tracks of electrons, that the complexity of damage may explain the slow kinetics of DNA DSB repair.

  13. A conceptual model of family surrogate end-of-life decision-making process in the nursing home setting: goals of care as guiding stars.

    Science.gov (United States)

    Bern-Klug, Mercedes

    2014-01-01

    An increasing proportion of dying is occurring in America's nursing homes (NH). Family members are involved in (and affected by) medical decision-making on behalf of NH residents approaching the end of life, especially when the resident is cognitively impaired. This article proposes an empirically derived conceptual model of the key factors NH family surrogate decision-makers consider when establishing or changing goals of care and the iterative process as applied to the NH setting. This model also establishes the importance of family social role expectations toward their loved one as well as the concept, "stance toward dying," as key in establishing or changing the main goal of care. NH staff and physicians can use the model as a framework for providing information and support to family members. Research is needed to better understand how to prepare staff and settings to support family surrogate decision-makers, in particular around setting goals of care. The model can be generalized beyond nursing homes.

  14. The Resource Benefits Evaluation Model on Remanufacturing Processes of End-of-Life Construction Machinery under the Uncertainty in Recycling Price

    Directory of Open Access Journals (Sweden)

    Qian-wang Deng

    2017-02-01

    Full Text Available In the process of end-of-life construction machinery remanufacturing, the existence of uncertainties in all aspects of the remanufacturing process increase the difficulty and complexity of resource benefits evaluation for them. To quantify the effects of those uncertainty factors, this paper makes a mathematical analysis of the recycling and remanufacturing processes, building a resource benefits evaluation model for the end-of-life construction machinery. The recycling price and the profits of remanufacturers can thereby be obtained with a maximum remanufacturing resource benefit. The study investigates the change regularity of the resource benefits, recycling price, and profits of remanufacturers when the recycling price, quality fluctuation coefficient, demand coefficient, and the reusing ratio of products or parts are varying. In the numerical experiment, we explore the effects of uncertainties on the remanufacturing decisions and the total expected costs. The simulated analysis shows when the quality fluctuation coefficient is approaching to 1, the values of the profits of remanufacturer, the maximal resource benefits and recycling price grade into constants.

  15. Hybrid FEA/SEA Assessment for an Orthogrid Cylindrical Panel Section and Periodic Subsystem Modeling Evaluation

    Science.gov (United States)

    Smith, Andrew M.; LaVerde, Bruce; Teague, David W.

    2010-01-01

    In the lower frequency range, where particular boundary conditions can make a significant difference to panel response characteristics Statistical Energy Analysis (SEA) has never been the analytical tool of choice. In addition to boundary condition effects, SEA is not well suited in frequency bands where no modes or less than a few modes exist. The advent of the Hybrid Module has enabled integration of Finite Element Analysis to expand and enhance the capability for response calculations within VA One into the lower frequency range. Exploration of several additional modeling approaches was completed for the cylindrical orthogrid panel test article that was examined in Reference 1. Comparison of the new analytical response predictions with the measured response data from ground test and the pure SEA results from the reference will be presented. One approach that is considered promising is the periodic subsystem capability. Initially, a detailed FEM of just one region of the test article is defined. After evaluating this small region using symmetric boundary conditions, the FEM may be expanded to determine the properties of the entire system using similar connected regions that map over the entire test article. Another approach is the direct use of a very detailed finite element model of the entire panel, explicitly modeling pocket and rib details of the structure. A third approach is to approximate localized structure geometry details with a smeared property generalization using a PCOMP (NASTRAN card used to define layered composite structures) to define skin layer and ribbed layer for the orthogrid panel. The authors expect to demonstrate that the integrated Hybrid/FEM approach increases confidence in response prediction in the lower frequency range (for example from 20-300 Hz for the test article under consideration). In addition the strength and weakness of each additional approach will be highlighted and compared to those reported with those reported in an

  16. Observation and characterization of flow in critical sections of a horizontal pressurized gating system using water models

    Directory of Open Access Journals (Sweden)

    Jaiganesh Venkataramani

    2013-07-01

    Full Text Available This work is concerned with the hydraulics and flow characterization in a pressurized, horizontal gating system with multiple ingates attached to a plate mold, using transparent water models. Runners with two different aspect ratios (w/h = 0.5 and 2 and four different types of ingates (rectangular, convergent, divergent and venturi were examined for their influence on flow behavior. Flow behavior was visualized using a high speed camera capable of capturing images up to 10,000 frames per second. Real time experimentation with a few runner – ingate combinations were carried out to validate the usefulness of water models in predicting the filling behavior. Comparison of the approaches provided useful insights into the filling behavior in critical sections of the flow passages as well as the utility of water models towards understanding of the filling behavior during real time casting.

  17. Comparison of GEANT4 very low energy cross section models with experimental data in water

    DEFF Research Database (Denmark)

    Incerti, S; Ivanchenko, A; Karamitros, M

    2010-01-01

    The GEANT4 general-purpose Monte Carlo simulation toolkit is able to simulate physical interaction processes of electrons, hydrogen and helium atoms with charge states (H0, H+) and (He0, He+, He2+), respectively, in liquid water, the main component of biological systems, down to the electron volt...... of electromagnetic interactions within the GEANT4 toolkit framework (since GEANT4 version 9.3 beta). This work presents a quantitative comparison of these physics models with a collection of experimental data in water collected from the literature....

  18. High-throughput detection of prostate cancer in histological sections using probabilistic pairwise Markov models.

    Science.gov (United States)

    Monaco, James P; Tomaszewski, John E; Feldman, Michael D; Hagemann, Ian; Moradi, Mehdi; Mousavi, Parvin; Boag, Alexander; Davidson, Chris; Abolmaesumi, Purang; Madabhushi, Anant

    2010-08-01

    In this paper we present a high-throughput system for detecting regions of carcinoma of the prostate (CaP) in HSs from radical prostatectomies (RPs) using probabilistic pairwise Markov models (PPMMs), a novel type of Markov random field (MRF). At diagnostic resolution a digitized HS can contain 80Kx70K pixels - far too many for current automated Gleason grading algorithms to process. However, grading can be separated into two distinct steps: (1) detecting cancerous regions and (2) then grading these regions. The detection step does not require diagnostic resolution and can be performed much more quickly. Thus, we introduce a CaP detection system capable of analyzing an entire digitized whole-mount HS (2x1.75cm(2)) in under three minutes (on a desktop computer) while achieving a CaP detection sensitivity and specificity of 0.87 and 0.90, respectively. We obtain this high-throughput by tailoring the system to analyze the HSs at low resolution (8microm per pixel). This motivates the following algorithm: (Step 1) glands are segmented, (Step 2) the segmented glands are classified as malignant or benign, and (Step 3) the malignant glands are consolidated into continuous regions. The classification of individual glands leverages two features: gland size and the tendency for proximate glands to share the same class. The latter feature describes a spatial dependency which we model using a Markov prior. Typically, Markov priors are expressed as the product of potential functions. Unfortunately, potential functions are mathematical abstractions, and constructing priors through their selection becomes an ad hoc procedure, resulting in simplistic models such as the Potts. Addressing this problem, we introduce PPMMs which formulate priors in terms of probability density functions, allowing the creation of more sophisticated models. To demonstrate the efficacy of our CaP detection system and assess the advantages of using a PPMM prior instead of the Potts, we alternately

  19. A constitutive model for the flow through an assembly of circular section rods

    International Nuclear Information System (INIS)

    Moeller, S.V.

    1979-08-01

    The determination of the flow through an uniform array of rod bundle is made by means of the Continuum Theories of Mixtures, which gives balance equations for the system. The hypotheses of isothermal and fully developed turbulent flow are made. Constitutive equations for the resistive force are determined from Jakob's and Rowe's correlations, and its behaviour analysed for a standard case. Comparison of these equations with Bottgenbach's experiments shows good agreement of the direction of the pressure, although direct comparison between present theory and his theory is not possible. For the confirmation of the model an experiment is performed, this consisting of measuring pressure drop (Euler's Number) in the axial and transverse direction of a random array rod bundle at various angles as functions of velocity (Reynold's Number), which has good agreement, except on axial direction. At last, a sample problem is formulated with the purpose of showing the applicability of the model, this being the determination of pressure field due to the influence of a baffle. (Author) [pt

  20. Modeling of the Section Capacitance to Interface with a S3R

    Directory of Open Access Journals (Sweden)

    Fernández A.

    2017-01-01

    Full Text Available Cell capacitance is a well-known parameter in silicon solar cells. Its effects on the power units, specially on the S3R, is also well known since it has to be taken into account to design them. The capacitor energy is dis-charged into the power switch and the dissipation in-creases. Moreover, it introduces a delay in the energy transfer from the array to the main power bus. In triple junction solar cells, this parasitic element becomes far more complex and is not so well characterized. This paper addresses this issue and proposes a large signal model to be used in combination with a S3R.

  1. Fission cross section calculations for 209Bi target nucleus based on fission reaction models in high energy regions

    Directory of Open Access Journals (Sweden)

    Kaplan Abdullah

    2015-01-01

    Full Text Available Implementation of projects of new generation nuclear power plants requires the solving of material science and technological issues in developing of reactor materials. Melts of heavy metals (Pb, Bi and Pb-Bi due to their nuclear and thermophysical properties, are the candidate coolants for fast reactors and accelerator-driven systems (ADS. In this study, α, γ, p, n and 3He induced fission cross section calculations for 209Bi target nucleus at high-energy regions for (α,f, (γ,f, (p,f, (n,f and (3He,f reactions have been investigated using different fission reaction models. Mamdouh Table, Sierk, Rotating Liquid Drop and Fission Path models of theoretical fission barriers of TALYS 1.6 code have been used for the fission cross section calculations. The calculated results have been compared with the experimental data taken from the EXFOR database. TALYS 1.6 Sierk model calculations exhibit generally good agreement with the experimental measurements for all reactions used in this study.

  2. Expanding vaccine efficacy estimation with dynamic models fitted to cross-sectional prevalence data post-licensure

    Directory of Open Access Journals (Sweden)

    Erida Gjini

    2016-03-01

    Full Text Available The efficacy of vaccines is typically estimated prior to implementation, on the basis of randomized controlled trials. This does not preclude, however, subsequent assessment post-licensure, while mass-immunization and nonlinear transmission feedbacks are in place. In this paper we show how cross-sectional prevalence data post-vaccination can be interpreted in terms of pathogen transmission processes and vaccine parameters, using a dynamic epidemiological model. We advocate the use of such frameworks for model-based vaccine evaluation in the field, fitting trajectories of cross-sectional prevalence of pathogen strains before and after intervention. Using SI and SIS models, we illustrate how prevalence ratios in vaccinated and non-vaccinated hosts depend on true vaccine efficacy, the absolute and relative strength of competition between target and non-target strains, the time post follow-up, and transmission intensity. We argue that a mechanistic approach should be added to vaccine efficacy estimation against multi-type pathogens, because it naturally accounts for inter-strain competition and indirect effects, leading to a robust measure of individual protection per contact. Our study calls for systematic attention to epidemiological feedbacks when interpreting population level impact. At a broader level, our parameter estimation procedure provides a promising proof of principle for a generalizable framework to infer vaccine efficacy post-licensure.

  3. Modeled Neutron Induced Nuclear Reaction Cross Sections for Radiochemsitry in the region of Thulium, Lutetium, and Tantalum I. Results of Built in Spherical Symmetry in a Deformed Region

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, R. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2013-09-06

    We have developed a set of modeled nuclear reaction cross sections for use in radiochemical diagnostics. Systematics for the input parameters required by the Hauser-Feshbach statistical model were developed and used to calculate neutron induced nuclear reaction cross sections for targets ranging from Terbium (Z = 65) to Rhenium (Z = 75). Of particular interest are the cross sections on Tm, Lu, and Ta including reactions on isomeric targets.

  4. The Levy sections theorem revisited

    International Nuclear Information System (INIS)

    Figueiredo, Annibal; Gleria, Iram; Matsushita, Raul; Silva, Sergio Da

    2007-01-01

    This paper revisits the Levy sections theorem. We extend the scope of the theorem to time series and apply it to historical daily returns of selected dollar exchange rates. The elevated kurtosis usually observed in such series is then explained by their volatility patterns. And the duration of exchange rate pegs explains the extra elevated kurtosis in the exchange rates of emerging markets. In the end, our extension of the theorem provides an approach that is simpler than the more common explicit modelling of fat tails and dependence. Our main purpose is to build up a technique based on the sections that allows one to artificially remove the fat tails and dependence present in a data set. By analysing data through the lenses of the Levy sections theorem one can find common patterns in otherwise very different data sets

  5. Lake Malawi sediment and pore water chemistry: Proposition of a conceptual model for stratification intensification since the end of the Little Ice Age

    Science.gov (United States)

    Branchu, Philippe; Bergonzini, Laurent; Pons-branchu, Edwige; Violier, Eric; Dittrich, Maria; Massault, Marc; Ghaleb, Bassam

    2010-07-01

    Sedimentary records of salinity indicators are largely used to reconstruct past climatic changes in lacustrine systems where chemistry is sensitive to hydroclimatic conditions. In large fresh lakes of the East African Rift such as Lakes Tanganyika and Malawi, salinity is often considered constant and other paleoclimatological proxy data are used. However, a relation between lake surface chloride concentration and hydroclimatic regime was previously demonstrated at the century scale in Lake Tanganyika. This relation is transposed to Lake Malawi on the base of similarity between hydrochemical budgets of both lakes that are computed for the whole lake and epilimnion. Whereas numerous physico-chemical difficulties make generally debatable use of lake pore water chemistry, as illustrated here by diffusion modelling, the dissolved chloride concentration profile from a core sampled in northern Lake Malawi is considered as a potential indicator of limnological-hydroclimatic condition changes for the last 200 years. A decrease in pore water chloride concentration between 1840 AD and present situation is directly associated to a metalimnetic water salinity decrease. The chronology of this event is synchronous with diatom productivity change demonstrated by Johnson et al. (2001) at the end of the Little Ice Age (LIA). A conceptual model of Lake Malawi, based on salinity, organic carbon and its "dead" watershed contribution, lake-level and productivity changes since the mid 19th century is presented. A new scenario is proposed, based on thermal stratification reinforcement at the end of the LIA. Lake productivity and chemistry depend on stratification strength, water column mixing rate and on climatic variability. During the LIA, nutrient distribution profiles were more homogeneous with depth due to the climatically (colder and drier climatic conditions than today) induced destabilisation of the mixing barrier. The productive system is then auto-supplied and does not require

  6. Mixture modeling methods for the assessment of normal and abnormal personality, part I: cross-sectional models.

    Science.gov (United States)

    Hallquist, Michael N; Wright, Aidan G C

    2014-01-01

    Over the past 75 years, the study of personality and personality disorders has been informed considerably by an impressive array of psychometric instruments. Many of these tests draw on the perspective that personality features can be conceptualized in terms of latent traits that vary dimensionally across the population. A purely trait-oriented approach to personality, however, might overlook heterogeneity that is related to similarities among subgroups of people. This article describes how factor mixture modeling (FMM), which incorporates both categories and dimensions, can be used to represent person-oriented and trait-oriented variability in the latent structure of personality. We provide an overview of different forms of FMM that vary in the degree to which they emphasize trait- versus person-oriented variability. We also provide practical guidelines for applying FMM to personality data, and we illustrate model fitting and interpretation using an empirical analysis of general personality dysfunction.

  7. SSC collider dipole magnet end mechanical design

    Energy Technology Data Exchange (ETDEWEB)

    Delchamps, S.W.; Bossert, R.C.; Carson, J.; Ewald, K.; Fulton, H.; Kerby, J.; Koska, W.; Strait, J.; Wake, S.M. (Fermi National Accelerator Lab., Batavia, IL (USA)); Leung, K.K. (Superconducting Super Collider Lab., Dallas, TX (USA))

    1991-05-01

    This paper describes the mechanical design of the ends of Superconducting Super Collider dipole magnets to be constructed and tested at Fermilab. Coil end clamps, end yoke configuration, and end plate design are discussed. Loading of the end plate by axial Lorentz forces is discussed. Relevant data from 40 mm and 50 mm aperture model dipole magnets built and tested at Fermilab are presented. In particular, the apparent influence of end clamp design on the quench behavior of model SSC dipoles is described. 8 refs., 3 figs.

  8. Testing a self-determination theory model of children's physical activity motivation: a cross-sectional study.

    Science.gov (United States)

    Sebire, Simon J; Jago, Russell; Fox, Kenneth R; Edwards, Mark J; Thompson, Janice L

    2013-09-26

    Understanding children's physical activity motivation, its antecedents and associations with behavior is important and can be advanced by using self-determination theory. However, research among youth is largely restricted to adolescents and studies of motivation within certain contexts (e.g., physical education). There are no measures of self-determination theory constructs (physical activity motivation or psychological need satisfaction) for use among children and no previous studies have tested a self-determination theory-based model of children's physical activity motivation. The purpose of this study was to test the reliability and validity of scores derived from scales adapted to measure self-determination theory constructs among children and test a motivational model predicting accelerometer-derived physical activity. Cross-sectional data from 462 children aged 7 to 11 years from 20 primary schools in Bristol, UK were analysed. Confirmatory factor analysis was used to examine the construct validity of adapted behavioral regulation and psychological need satisfaction scales. Structural equation modelling was used to test cross-sectional associations between psychological need satisfaction, motivation types and physical activity assessed by accelerometer. The construct validity and reliability of the motivation and psychological need satisfaction measures were supported. Structural equation modelling provided evidence for a motivational model in which psychological need satisfaction was positively associated with intrinsic and identified motivation types and intrinsic motivation was positively associated with children's minutes in moderate-to-vigorous physical activity. The study provides evidence for the psychometric properties of measures of motivation aligned with self-determination theory among children. Children's motivation that is based on enjoyment and inherent satisfaction of physical activity is associated with their objectively-assessed physical

  9. Testing a self-determination theory model of children’s physical activity motivation: a cross-sectional study

    Science.gov (United States)

    2013-01-01

    Background Understanding children’s physical activity motivation, its antecedents and associations with behavior is important and can be advanced by using self-determination theory. However, research among youth is largely restricted to adolescents and studies of motivation within certain contexts (e.g., physical education). There are no measures of self-determination theory constructs (physical activity motivation or psychological need satisfaction) for use among children and no previous studies have tested a self-determination theory-based model of children’s physical activity motivation. The purpose of this study was to test the reliability and validity of scores derived from scales adapted to measure self-determination theory constructs among children and test a motivational model predicting accelerometer-derived physical activity. Methods Cross-sectional data from 462 children aged 7 to 11 years from 20 primary schools in Bristol, UK were analysed. Confirmatory factor analysis was used to examine the construct validity of adapted behavioral regulation and psychological need satisfaction scales. Structural equation modelling was used to test cross-sectional associations between psychological need satisfaction, motivation types and physical activity assessed by accelerometer. Results The construct validity and reliability of the motivation and psychological need satisfaction measures were supported. Structural equation modelling provided evidence for a motivational model in which psychological need satisfaction was positively associated with intrinsic and identified motivation types and intrinsic motivation was positively associated with children’s minutes in moderate-to-vigorous physical activity. Conclusions The study provides evidence for the psychometric properties of measures of motivation aligned with self-determination theory among children. Children’s motivation that is based on enjoyment and inherent satisfaction of physical activity is

  10. Development of a global aerosol model using a two-dimensional sectional method: 2. Evaluation and sensitivity simulations

    Science.gov (United States)

    Matsui, H.; Mahowald, N.

    2017-08-01

    Global aerosol simulations are conducted by using the Community Atmosphere Model version 5 with the Aerosol Two-dimensional bin module for foRmation and Aging Simulation version 2 (CAM5-chem/ATRAS2) which was developed in part 1. The model uses a two-dimensional (2-D) section representation with 12 size bins from 1 nm to 10 μm and 8 black carbon (BC) mixing state bins, and it can calculate detailed aerosol processes and their interactions with radiation and clouds. The simulations have similar or better agreement with aerosol observations (e.g., aerosol optical depth, absorption aerosol optical depth (AAOD), aerosol number concentrations, mass concentrations of each species) compared with the simulations using the Modal Aerosol Model with three modes. Sensitivity simulations show that global mean AAOD is reduced by 15% by resolving BC mixing state as a result of two competing effects (optical and lifetime effects). AAOD is reduced by 10-50% at low and midlatitudes in the 2-D sectional simulation because BC absorption enhancement by coating species is reduced by resolving pure BC, thinly coated BC, and BC-free particles in the model (optical effect). In contrast, AAOD is enhanced by 5-30% at high-latitudes because BC concentrations are enhanced by 40-200% over the regions by resolving less CCN active particles (lifetime effect). The simulations also suggest a model which resolves more than 3 BC categories (including BC-free particles) is desirable to calculate the optical and lifetime effects accurately. The complexity of aerosol representation is shown to be especially important for simulations of BC and CCN concentrations and AAOD.

  11. Intercomparison of modal and sectional aerosol microphysics representations within the same 3-D global chemical transport model

    Directory of Open Access Journals (Sweden)

    G. W. Mann

    2012-05-01

    Full Text Available In the most advanced aerosol-climate models it is common to represent the aerosol particle size distribution in terms of several log-normal modes. This approach, motivated by computational efficiency, makes assumptions about the shape of the particle distribution that may not always capture the properties of global aerosol. Here, a global modal aerosol microphysics module (GLOMAP-mode is evaluated and improved by comparing against a sectional version (GLOMAP-bin and observations in the same 3-D global offline chemistry transport model. With both schemes, the model captures the main features of the global particle size distribution, with sub-micron aerosol approximately unimodal in continental regions and bi-modal in marine regions. Initial bin-mode comparisons showed that the current values for two size distribution parameter settings in the modal scheme (mode widths and inter-modal separation sizes resulted in clear biases compared to the sectional scheme. By adjusting these parameters in the modal scheme, much better agreement is achieved against the bin scheme and observations. Annual mean surface-level mass of sulphate, sea-salt, black carbon (BC and organic carbon (OC are within 25% in the two schemes in nearly all regions. Surface level concentrations of condensation nuclei (CN, cloud condensation nuclei (CCN, surface area density and condensation sink also compare within 25% in most regions. However, marine CCN concentrations between 30° N and 30° S are systematically 25–60% higher in the modal model, which we attribute to differences in size-resolved particle growth or cloud-processing. Larger differences also exist in regions or seasons dominated by biomass burning and in free-troposphere and high-latitude regions. Indeed, in the free-troposphere, GLOMAP-mode BC is a factor 2–4 higher than GLOMAP-bin, likely due to differences in size-resolved scavenging. Nevertheless, in most parts of the atmosphere, we conclude that bin

  12. Modal Bin Hybrid Model: A surface area consistent, triple-moment sectional method for use in process-oriented modeling of atmospheric aerosols

    Science.gov (United States)

    Kajino, Mizuo; Easter, Richard C.; Ghan, Steven J.

    2013-09-01

    triple-moment sectional (TMS) aerosol dynamics model, Modal Bin Hybrid Model (MBHM), has been developed. In addition to number and mass (volume), surface area is predicted (and preserved), which is important for aerosol processes and properties such as gas-to-particle mass transfer, heterogeneous reaction, and light extinction cross section. The performance of MBHM was evaluated against double-moment sectional (DMS) models with coarse (BIN4) to very fine (BIN256) size resolutions for simulating evolution of particles under simultaneously occurring nucleation, condensation, and coagulation processes (BINx resolution uses x sections to cover the 1 nm to 1 µm size range). Because MBHM gives a physically consistent form of the intrasectional distributions, errors and biases of MBHM at BIN4-8 resolution were almost equivalent to those of DMS at BIN16-32 resolution for various important variables such as the moments Mk (k: 0, 2, 3), dMk/dt, and the number and volume of particles larger than a certain diameter. Another important feature of MBHM is that only a single bin is adequate to simulate full aerosol dynamics for particles whose size distribution can be approximated by a single lognormal mode. This flexibility is useful for process-oriented (multicategory and/or mixing state) modeling: Primary aerosols whose size parameters would not differ substantially in time and space can be expressed by a single or a small number of modes, whereas secondary aerosols whose size changes drastically from 1 to several hundred nanometers can be expressed by a number of modes. Added dimensions can be applied to MBHM to represent mixing state or photochemical age for aerosol mixing state studies.

  13. Determining SUSY model parameters and masses at the LHC using cross sections, kinematic edges and other observables

    CERN Document Server

    White, M J; Parker, M A

    2005-01-01

    We address the problem of mass measurements of supersymmetric particles at the Large Hadron Collider, using the ATLAS detector as an example. By using Markov Chain sampling techniques to combine standard measurements of kinematic edges in the invariant mass distributions of decay products with a measurement of a missing $p_T$ cross-section, we show that the precision of mass measurements at the LHC can be dramatically improved, even when we do not assume that we have measured the kinematic endpoints precisely, or that we have identified exactly which particles are involved in the decay chain causing the endpoints. The generality of the technique is demonstrated in a preliminary investigation of a non-universal SUGRA model, in which we relax the requirements of mSUGRA by breaking the degeneracy of the GUT scale gaugino masses. The model studied is compatible with the WMAP limits on dark matter relic density.

  14. Analysis on the uniformly loaded rectangular cross-section cantilever by a modified load-deflection model

    Science.gov (United States)

    Tsai, Shang-Hsi; Wang, Yeng-Tseng; Kan, Heng-Chuan

    2009-02-01

    The load-deflection relationship of the uniformly loaded rectangular cross-section cantilever is analysed by a modified mechanical model, which exhibits its conformity to the physical situation by considering both the tangential and normal surface stresses. The analytical solution of the modelling equation is solved and presented in terms of the first and the second kinds of the Airy functions in association with Scorer's function. The resultant deflection profile contains an inflection point due to the restoring bending moment contributed by the critical surface loadings. The relationships of the tip deflection and the loading scenario are investigated, which reveal the fact that various loading scenarios can result in different deflection profiles, albeit with the same tip deflection. A numerical algorithm is given in the appendix to solve the loading scenario, by which the surface loadings can formally be determined for the designated applications for the devices utilizing the cantilever structure.

  15. A two-dimensional model of the pressing section of a paper machine including dynamic capillary effects

    KAUST Repository

    Iliev, Oleg P.

    2013-05-15

    Paper production is a problem with significant importance for society; it is also a challenging topic for scientific investigation. This study is concerned with the simulation of the pressing section of a paper machine. A two-dimensional model is developed to account for the water flow within the pressing zone. A Richards-type equation is used to describe the flow in the unsaturated zone. The dynamic capillary pressure-saturation relation is adopted for the paper production process. The mathematical model accounts for the coexistence of saturated and unsaturated zones in a multilayer computational domain. The discretization is performed by the MPFA-O method. Numerical experiments are carried out for parameters that are typical of the production process. The static and dynamic capillary pressure-saturation relations are tested to evaluate the influence of the dynamic capillary effect. © 2013 Springer Science+Business Media Dordrecht.

  16. Interpretation of seismic section by acoustic modeling. Study of large amplitude events; Hadoba modeling ni yoru jishin tansa danmen no kaishaku. Kyoshinhaba event ni taisuru kosatsu

    Energy Technology Data Exchange (ETDEWEB)

    Tamagawa, T.; Matsuoka, T.; Sato, T. [Japan Petroleum Exploration Corp., Tokyo (Japan); Minegishi, M.; Tsuru, T. [Japan National Oil Corp., Tokyo (Japan)

    1996-05-01

    A large amplitude event difficult to interpret was discovered in the overlap section in offset data beyond 10km targeting at deep structures, and the event was examined. A wave field modeling was carried out by use of a simplified synclinal structure model because it had been estimated that the large amplitude event had something to do with a synclinal structure. A pseudospectral program was used for modeling the wave field on the assumption that the synclinal structure model would be an acoustic body and that the surface would contain free boundaries and multiple reflection. It was found as the result that a discontinuous large amplitude event is mapped out in the synclinal part of the overlap section when a far trace is applied beyond the structure during a CMP overlap process. This can be attributed to the concentration of energy produced by multiple reflection in the synclinal part and by the reflection waves beyond the critical angle. Accordingly, it is possible that phenomena similar to those encountered in the modeling process are emerging during actual observation. 2 refs., 8 figs.

  17. Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain

    Directory of Open Access Journals (Sweden)

    Arjun eMuralidharan

    2016-05-01

    Full Text Available Establishment and validation of ethologically-relevant, non-evoked behavioral end-points as surrogate measures of spontaneous pain in rodent pain models has been proposed as a means to improve preclinical to clinical research translation in the pain field. Here, we compared the utility of burrowing behavior with hypersensitivity to applied mechanical stimuli for pain assessment in rat models of chronic inflammatory and peripheral neuropathic pain. Briefly, groups of male Sprague-Dawley rats were habituated to the burrowing environment and trained over a 5-day period. Rats that burrowed ≤450g of gravel on any two days of the individual training phase were excluded from the study. The remaining rats received either a unilateral intraplantar injection of Freund’s complete adjuvant (FCA or saline, or underwent unilateral chronic constriction injury (CCI of the sciatic nerve- or sham-surgery. Baseline burrowing behavior and evoked pain behaviors were assessed prior to model induction, and twice-weekly until study completion on day 14. For FCA- and CCI-rats, but not the corresponding groups of sham-rats, evoked mechanical hypersensitivity developed in a temporal manner in the ipsilateral hindpaws. Although burrowing behavior also decreased in a temporal manner for both FCA- and CCI-rats, there was considerable inter-animal variability. By contrast, mechanical hyperalgesia and mechanical allodynia in the ipsilateral hindpaws of FCA- and CCI-rats respectively, exhibited minimal inter-animal variability. Our data collectively show that burrowing behavior is altered in rodent models of chronic inflammatory pain and peripheral neuropathic pain. However, large group sizes are needed to ensure studies are adequately powered due to considerable inter-animal variability.

  18. Modelling the flow and the two-phase science of heat inside a cross-section tube of a 'once through' vapor generator overheated with sodium

    International Nuclear Information System (INIS)

    Mutelle, H.

    1997-01-01

    Concerning the future fast neutrons reactors, studied in the frame of the European Fast Reactor (E.F.R.) project, several innovations have been proposed particularly in the field of vapor generators. These vapor generators have the particularity to use two different exchange fluids which can react violently one with the other. The thermodynamic fluid or secondary fluid is water under high pressure (18.5 MPa) which comes under saturated in the inlet of the device, warms and vaporizes inside the nest of boiler-tubes. At the outlet, vapor is overheated. The primary fluid is a liquid metal (sodium for French reactors) which flows outside the nest of boiler-tubes in the opposite direction of the secondary fluid. Several vapor generators models have been carried out. Concerning the European Fast Reactor project, the tubes have a cross-section and are in ferritic steel. Inside the boiler-tubes, the water-vapor flow can be divided into three areas. The first one is the liquid monophasic rate. It ends by the start of the boiling which is nucleated in the shell. Downstream, the two-phase flow passes from a bubbles flow to an annular flow. The liquid is then on the form of shell film and on the form of droplets carried along by the vapor flux. The dryout of the annular film is the start of the third area where there is vapor forced convection. At the present time, there is still no thermohydraulic code in the conditions of the E.F.R. vapor generator. In order to have a reliable size tool, the members of the E.F.R. project have then decided to do a two-phase flow model and have experimented a mono tubular scale model called ''ATLAS'' which represents well the real component for size, fluids and running conditions. The aim of the present work is then, in the frame of this experimental program, to 1)qualify the heat exchange and friction laws which will be later introduced in the thermohydraulic codes of cross-sections vapor generators 2)characterize the dryout phenomenon 3

  19. End-to-end network/application performance troubleshooting methodology

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Wenji; Bobyshev, Andrey; Bowden, Mark; Crawford, Matt; Demar, Phil; Grigaliunas, Vyto; Grigoriev, Maxim; Petravick, Don; /Fermilab

    2007-09-01

    The computing models for HEP experiments are globally distributed and grid-based. Obstacles to good network performance arise from many causes and can be a major impediment to the success of the computing models for HEP experiments. Factors that affect overall network/application performance exist on the hosts themselves (application software, operating system, hardware), in the local area networks that support the end systems, and within the wide area networks. Since the computer and network systems are globally distributed, it can be very difficult to locate and identify the factors that are hurting application performance. In this paper, we present an end-to-end network/application performance troubleshooting methodology developed and in use at Fermilab. The core of our approach is to narrow down the problem scope with a divide and conquer strategy. The overall complex problem is split into two distinct sub-problems: host diagnosis and tuning, and network path analysis. After satisfactorily evaluating, and if necessary resolving, each sub-problem, we conduct end-to-end performance analysis and diagnosis. The paper will discuss tools we use as part of the methodology. The long term objective of the effort is to enable site administrators and end users to conduct much of the troubleshooting themselves, before (or instead of) calling upon network and operating system 'wizards,' who are always in short supply.

  20. Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease.

    Science.gov (United States)

    Choi, Bo-Ryoung; Cho, Woo-Hyun; Kim, Jiyoung; Lee, Hyong Joo; Chung, ChiHye; Jeon, Won Kyung; Han, Jung-Soo

    2014-02-07

    The receptor for advanced glycation end products (RAGE) has been reported to have a pivotal role in the pathogenesis of Alzheimer's disease (AD). This study investigated RAGE levels in the hippocampus and cortex of a triple transgenic mouse model of AD (3xTg-AD) using western blotting and immunohistochemical double-labeling to assess cellular localization. Analysis of western blots showed that there were no differences in the hippocampal and cortical RAGE levels in 10-month-old adult 3xTg-AD mice, but significant increases in RAGE expression were found in the 22- to 24-month-old aged 3xTg-AD mice compared with those of age-matched controls. RAGE-positive immunoreactivity was observed primarily in neurons of aged 3xTg-AD mice with very little labeling in non-neuronal cells, with the notable exception of RAGE presence in astrocytes in the hippocampal area CA1. In addition, RAGE signals were co-localized with the intracellular amyloid precursor protein (APP)/amyloid beta (Aβ) but not with the extracellular APP/Aβ. In aged 3xTg-AD mice, expression of human tau was observed in the hippocampal area CA1 and co-localized with RAGE signals. The increased presence of RAGE in the 3xTg-AD animal model showing critical aspects of AD neuropathology indicates that RAGE may contribute to cellular dysfunction in the AD brain.

  1. Improved waiting-list outcomes in Argentina after the adoption of a model for end-stage liver disease-based liver allocation policy.

    Science.gov (United States)

    Cejas, Nora Gabriela; Villamil, Federico G; Lendoire, Javier C; Tagliafichi, Viviana; Lopez, Arturo; Krogh, Daniela Hansen; Soratti, Carlos A; Bisigniano, Liliana

    2013-07-01

    In July 2005, Argentina became the first country after the United States to introduce the Model for End-Stage Liver Disease (MELD) for organ allocation. In this study, we investigated waiting-list (WL) outcomes (n = 3272) and post-liver transplantation (LT) survival in 2 consecutive periods of 5 years before and after the implementation of a MELD-based allocation policy. Data were obtained from the database of the national institute for organ allocation in Argentina. After the adoption of the MELD system, there were significant reductions in WL mortality [28.5% versus 21.9%, P statistics of 0.828 and 0.857, respectively (P  30 had lower posttransplant survival, the global accuracy of the score for predicting outcomes was poor, as indicated by a c statistic of only 0.523. Patients with granted MELD exceptions (158 for hepatocellular carcinoma and 52 for other reasons) had significantly higher access to LT (80.4%) in comparison with nonexception patients with equivalent listing priority (MELD score = 18-25; 54.6%, P adoption of the MELD model in Argentina has resulted in improved liver organ allocation without compromising posttransplant survival. © 2013 American Association for the Study of Liver Diseases.

  2. Identification and segmentation of myelinated nerve fibers in a cross-sectional optical microscopic image using a deep learning model.

    Science.gov (United States)

    Naito, Tatsuhiko; Nagashima, Yu; Taira, Kenichiro; Uchio, Naohiro; Tsuji, Shoji; Shimizu, Jun

    2017-11-01

    The morphometric analysis of myelinated nerve fibers of peripheral nerves in cross-sectional optical microscopic images is valuable. Several automated methods for nerve fiber identification and segmentation have been reported. This paper presents a new method that uses a deep learning model of a convolutional neural network (CNN). We tested it for human sural nerve biopsy images. The method comprises four steps: normalization, clustering segmentation, myelinated nerve fiber identification, and clump splitting. A normalized sample image was separated into individual objects with clustering segmentation. Each object was applied to a CNN deep learning model that labeled myelinated nerve fibers as positive and other structures as negative. Only positives proceeded to the next step. For pretraining the model, 70,000 positive and negative data each from 39 samples were used. The accuracy of the proposed algorithm was evaluated using 10 samples that were not part of the training set. A P-value of segmented myelin sheaths were 0.967 and 0.068, respectively. In all but one sample, there were no significant differences in estimated morphometric parameters obtained from our method and manual segmentation. The TPR and AS were higher than those obtained using previous methods. High-performance automated identification and segmentation of myelinated nerve fibers were achieved using a deep learning model. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Fuel rod end plug

    International Nuclear Information System (INIS)

    McGeary, R.K.; Bucher, G.D.

    1989-01-01

    This patent describes an end plug for welded disposition within the end of a tube. It comprises a circumferentially extending, axially oriented land surface, having a radial extent defined by means of a first predetermined dimension, for disposition within the end of the tube; a circumferentially extending, axially oriented land surface, having a radial extent defined by means of a second predetermined dimension which is greater than the first predetermined dimension, for disposition outside of the end of the tube. The second land surface being disposed upstream of the first land surface; an annularly extending, radially oriented shoulder portion, defined at the downstream end of the second land surface and having a radially inward depth which is greater than the difference defined between the first and second radial dimensions of the first and second land surfaces, for engaging the end of the tube in a butt contact fashion; and annular groove means defined between the upstream end of the first land surface and the shoulder portion of the end plug, for eliminating porosity defects normally developed within a weldment defined between the tube end and the end plug when the end plug is welded within the tube end, and including a conical surface which extends radially outwardly from the innermost radial depth extent of the shoulder portion to the upstream end of the first land surface

  4. Cross section and di-fermionic asymmetry measurements by ALEPH detector at LEP2 - Interpretations beyond Standard Model; Mesures des sections efficaces et des asymetries difermioniques avec le detecteur Aleph a LEP2 - Interpretations au-dela du Modele Standard

    Energy Technology Data Exchange (ETDEWEB)

    Merle, Elsa [Laboratoire d' Annecy-le-vieux de physique des particules, Grenoble-1 Univ., 74 Annecy (France)

    1999-04-22

    The present work is based on the selection of e{sup -}e{sup +} {yields} f f-bar events taken with the ALEPH detector from 1995 to 1998, for an integrated luminosity of 500 pb{sup -}. We first present the selection of dimuon, di-tau and di-electron events that we have been developed for this study. The hadronic selection used in ALEPH is also detailed in a devoted part. In each case, the estimation of systematic uncertainties is described. They are of the same order of magnitude as the statistical errors, ranging between 0.6% (di-electron) and 3.5% (dimuon). From these selections we derive the di-fermionic cross-sections as well as the asymmetries computed for the di-lepton channels. Measurements are found to be in reasonable agreement with the Standard Model expectations. Cross-sections and asymmetries are sensitive to the presence of possible new physics. In this document we use the context of the 4-fermion contact interactions to set limits on the energy scale of new physics. Such limits are found to range between 7 and 15 GeV depending on the modelling used. We also put lower limits on the mass of leptoquarks, 590 GeV/c{sup 2} for vector leptoquarks and 71 GeV/c{sup 2} for scalar leptoquarks. Eventually we also present the limits derived in the context of R-parity violated supersymmetry, putting constraint on the s-neutrino mass. Our study excludes such particles below a few hundred GeV/c{sup 2} mass for high values of their Yukawa coupling assumptions.

  5. Receptor for advanced glycation end-products and World Trade Center particulate induced lung function loss: A case-cohort study and murine model of acute particulate exposure.

    Science.gov (United States)

    Caraher, Erin J; Kwon, Sophia; Haider, Syed H; Crowley, George; Lee, Audrey; Ebrahim, Minah; Zhang, Liqun; Chen, Lung-Chi; Gordon, Terry; Liu, Mengling; Prezant, David J; Schmidt, Ann Marie; Nolan, Anna

    2017-01-01

    World Trade Center-particulate matter(WTC-PM) exposure and metabolic-risk are associated with WTC-Lung Injury(WTC-LI). The receptor for advanced glycation end-products (RAGE) is most highly expressed in the lung, mediates metabolic risk, and single-nucleotide polymorphisms at the AGER-locus predict forced expiratory volume(FEV). Our objectives were to test the hypotheses that RAGE is a biomarker of WTC-LI in the FDNY-cohort and that loss of RAGE in a murine model would protect against acute PM-induced lung disease. We know from previous work that early intense exposure at the time of the WTC collapse was most predictive of WTC-LI therefore we utilized a murine model of intense acute PM-exposure to determine if loss of RAGE is protective and to identify signaling/cytokine intermediates. This study builds on a continuing effort to identify serum biomarkers that predict the development of WTC-LI. A case-cohort design was used to analyze a focused cohort of male never-smokers with normal pre-9/11 lung function. Odds of developing WTC-LI increased by 1.2, 1.8 and 1.0 in firefighters with soluble RAGE (sRAGE)≥97pg/mL, CRP≥2.4mg/L, and MMP-9≤397ng/mL, respectively, assessed in a multivariate logistic regression model (ROCAUC of 0.72). Wild type(WT) and RAGE-deficient(Ager-/-) mice were exposed to PM or PBS-control by oropharyngeal aspiration. Lung function, airway hyperreactivity, bronchoalveolar lavage, histology, transcription factors and plasma/BAL cytokines were quantified. WT-PM mice had decreased FEV and compliance, and increased airway resistance and methacholine reactivity after 24-hours. Decreased IFN-γ and increased LPA were observed in WT-PM mice; similar findings have been reported for firefighters who eventually develop WTC-LI. In the murine model, lack of RAGE was protective from loss of lung function and airway hyperreactivity and was associated with modulation of MAP kinases. We conclude that in a multivariate adjusted model increased sRAGE is

  6. Receptor for advanced glycation end-products and World Trade Center particulate induced lung function loss: A case-cohort study and murine model of acute particulate exposure.

    Directory of Open Access Journals (Sweden)

    Erin J Caraher

    Full Text Available World Trade Center-particulate matter(WTC-PM exposure and metabolic-risk are associated with WTC-Lung Injury(WTC-LI. The receptor for advanced glycation end-products (RAGE is most highly expressed in the lung, mediates metabolic risk, and single-nucleotide polymorphisms at the AGER-locus predict forced expiratory volume(FEV. Our objectives were to test the hypotheses that RAGE is a biomarker of WTC-LI in the FDNY-cohort and that loss of RAGE in a murine model would protect against acute PM-induced lung disease. We know from previous work that early intense exposure at the time of the WTC collapse was most predictive of WTC-LI therefore we utilized a murine model of intense acute PM-exposure to determine if loss of RAGE is protective and to identify signaling/cytokine intermediates. This study builds on a continuing effort to identify serum biomarkers that predict the development of WTC-LI. A case-cohort design was used to analyze a focused cohort of male never-smokers with normal pre-9/11 lung function. Odds of developing WTC-LI increased by 1.2, 1.8 and 1.0 in firefighters with soluble RAGE (sRAGE≥97pg/mL, CRP≥2.4mg/L, and MMP-9≤397ng/mL, respectively, assessed in a multivariate logistic regression model (ROCAUC of 0.72. Wild type(WT and RAGE-deficient(Ager-/- mice were exposed to PM or PBS-control by oropharyngeal aspiration. Lung function, airway hyperreactivity, bronchoalveolar lavage, histology, transcription factors and plasma/BAL cytokines were quantified. WT-PM mice had decreased FEV and compliance, and increased airway resistance and methacholine reactivity after 24-hours. Decreased IFN-γ and increased LPA were observed in WT-PM mice; similar findings have been reported for firefighters who eventually develop WTC-LI. In the murine model, lack of RAGE was protective from loss of lung function and airway hyperreactivity and was associated with modulation of MAP kinases. We conclude that in a multivariate adjusted model increased s

  7. Climate change projections for the tropical Andes using a regional climate model: Temperature and precipitation simulations for the end of the 21st century

    Science.gov (United States)

    Urrutia, RocíO.; Vuille, Mathias

    2009-01-01

    High-elevation tropical mountain regions may be more strongly affected by future climate change than their surrounding lowlands. In the tropical Andes a significant increase in temperature and changes in precipitation patterns will likely affect size and distribution of glaciers and wetlands, ecosystem integrity, and water availability for human consumption, irrigation, and power production. However, detailed projections of future climate change in the tropical Andes are not yet available. Here we present first results for the end of the 21st century (2071-2100) using a regional climate model (RCM) based on two different emission scenarios (A2 and B2). The model adequately simulates the spatiotemporal variability of precipitation and temperature but displays a cool and wet bias, in particular along the eastern Andean slope during the wet season, December-February. Projections of changes in the 21st century indicate significant warming in the tropical Andes, which is enhanced at higher elevations and further amplified in the middle and upper troposphere. Temperature changes are spatially similar in both scenarios, but the amplitude is significantly higher in RCM-A2. The RCM-A2 scenario also shows a significant increase in interannual temperature variability, while it remains almost unchanged in RCM-B2 when compared to a 20th century control run. Changes in precipitation are spatially much less coherent, with both regions of increased and decreased precipitation across the Andes. These results provide a first attempt at quantifying future climate change in the tropical Andes and could serve as input for impact models to simulate anticipated changes in Andean glaciation, hydrology, and ecosystem integrity.

  8. The receptor for advanced glycation end products is required for β‐catenin stabilization in a chemical‐induced asthma model

    Science.gov (United States)

    Yao, Lihong; Zhao, Haijin; Tang, Haixiong; Liang, Junjie; Liu, Laiyu; Dong, Hangming; Zou, Fei

    2016-01-01

    Background and Purpose Cytoplasmic retention of β‐catenin will lead to its nuclear translocation and subsequent interaction with the transcription factor TCF/LEF that regulates target gene expression. We have previously demonstrated aberrant expression of β‐catenin in a model of asthma induced by toluene diisocyanate (TDI). The aim of this study was to examine whether the receptor for advanced glycation end products (RAGE) can regulate β‐catenin expression in TDI‐induced asthma. Experimental Approach Male BALB/c mice were sensitized and challenged with TDI to generate a chemically‐induced asthma model. Inhibitors of RAGE, FPS‐ZM1 and the RAGE antagonist peptide (RAP), were injected i.p. after each challenge. Airway resistance was measured in vivo and bronchoalveolar lavage fluid was analysed. Lungs were examined by histology and immunohistochemistry. Western blotting and quantitative PCR were also used. Key Results Expression of RAGE and of its ligands HMGB1, S100A12, S100B, HSP70 was increased in TDI‐exposed lungs. These increases were inhibited by FPS‐ZM1 or RAP. Either antagonist blunted airway reactivity, airway inflammation and goblet cell metaplasia, and decreased release of Th2 cytokines. TDI exposure decreased level of membrane β‐catenin, phosphorylated Akt (Ser473), inactivated GSK3β (Ser9), dephosphorylated β‐catenin at Ser33/37/Thr41, which controls its cytoplasmic degradation, increased phosphorylated β‐catenin at Ser552, raised cytoplasmic and nuclear levels of β‐catenin and up‐regulated its targeted gene expression (MMP2, MMP7, MMP9, VEGF, cyclin D1, fibronectin), all of which were reversed by RAGE inhibition. Conclusion and Implications RAGE was required for stabilization of β‐catenin in TDI‐induced asthma, identifying protective effects of RAGE blockade in this model. PMID:27332707

  9. End of Life Issues

    Science.gov (United States)

    Planning for the end of life can be difficult. But by deciding what end-of-life care best suits your needs when you are healthy, you can ... right choices when the time comes. End-of-life planning usually includes making choices about the following: ...

  10. Measurements and analysis of end-to-end Internet dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Paxson, Vern [Univ. of California, Berkeley, CA (United States). Computer Science Division

    1997-04-01

    Accurately characterizing end-to-end Internet dynamics - the performance that a user actually obtains from the lengthy series of network links that comprise a path through the Internet - is exceptionally difficult, due to the network`s immense heterogeneity. At the heart of this work is a `measurement framework` in which a number of sites around the Internet host a specialized measurement service. By coordinating `probes` between pairs of these sites one can measure end-to-end behavior along O(N2) paths for a framework consisting of N sites. Consequently, one obtains a superlinear scaling that allows measuring a rich cross-section of Internet behavior without requiring huge numbers of observation points. 37 sites participated in this study, allowing the author to measure more than 1,000 distinct Internet paths. The first part of this work looks at the behavior of end-to-end routing: the series of routers over which a connection`s packets travel. Based on 40,000 measurements made using this framework, the author analyzes: routing `pathologies` such as loops, outages, and flutter; the stability of routes over time; and the symmetry of routing along the two directions of an end-to-end path. The author finds that pathologies increased significantly over the course of 1995 and that Internet paths are heavily dominated by a single route. The second part of this work studies end-to-end Internet packet dynamics. The author analyzes 20,000 TCP transfers of 100 Kbyte each to investigate the performance of both the TCP endpoints and the Internet paths. The measurements used for this part of the study are much richer than those for the first part, but require a great degree of attention to issues of calibration, which are addressed by applying self-consistency checks to the measurements whenever possible. The author finds that packet filters are capable of a wide range of measurement errors, some of which, if undetected, can significantly taint subsequent analysis.

  11. Discrete symmetries, spectra, degeneracies, cross sections: a toy model with interactions centred at the vertices of Platonic solids

    International Nuclear Information System (INIS)

    De Prunelé, E

    2012-01-01

    The point spectrum, its degeneracy degrees and the symmetry properties of eigenstates are determined for a one-particle Hamiltonian with interactions centred at the vertices of the five Platonic solids, within the framework of an exactly solvable non-relativistic quantum-mechanical model. The interaction at a given vertex is a projector on the s wave relative to this vertex. The critical points in the parameter space of the Hamiltonian, i.e. points where a bound state appears or disappears, are determined analytically. The positive-energy domain corresponding to the scattering of a particle is also investigated. A simple formula for the limit of the total cross section at zero energy is obtained. (paper)

  12. Five Factor Model personality disorder scales: An introduction to a special section on assessment of maladaptive variants of the five factor model.

    Science.gov (United States)

    Bagby, R Michael; Widiger, Thomas A

    2018-01-01

    The Five-Factor Model (FFM) is a dimensional model of general personality structure, consisting of the domains of neuroticism (or emotional instability), extraversion versus introversion, openness (or unconventionality), agreeableness versus antagonism, and conscientiousness (or constraint). The FFM is arguably the most commonly researched dimensional model of general personality structure. However, a notable limitation of existing measures of the FFM has been a lack of coverage of its maladaptive variants. A series of self-report inventories has been developed to assess for the maladaptive personality traits that define Diagnostic and Statistical Manual of Mental Disorders (fifth edition; DSM-5) Section II personality disorders (American Psychiatric Association [APA], 2013) from the perspective of the FFM. In this paper, we provide an introduction to this Special Section, presenting the rationale and empirical support for these measures and placing them in the historical context of the recent revision to the APA diagnostic manual. This introduction is followed by 5 papers that provide further empirical support for these measures and address current issues within the personality assessment literature. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  13. 49 CFR 238.413 - End structures of trailer cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false End structures of trailer cars. 238.413 Section... II Passenger Equipment § 238.413 End structures of trailer cars. (a) Except as provided in paragraph (b) of this section, the end structure of a trailer car shall be designed to include the following...

  14. Variant outcomes of liver transplantation for hepatitis C virus patients in different age categories: impact of the model for end-stage liver disease score.

    Science.gov (United States)

    Hu, Zhenhua; Zhou, Jie; Li, Zhiwei; Xiang, Jie; Zhang, Qijun; Yan, Sheng; Wu, Jian; Zhang, Min; Wang, Weilin; Zheng, Shusen

    2017-04-01

    Whether the introduction of model for end-stage liver disease (MELD) has an effect on transplant outcome for different age categories remain unclear. We analyzed 49,762 adult hepatitis C virus (HCV) candidates through 1 January 1995 to 31 December 2012 from the Scientific Registry of Transplant Recipients. Patients were divided into four age categories (18-34, 35-49, 60-64, ≥65 years) in the pre-MELD era and MELD era, respectively. Waiting list dropouts have decreased in the MELD era for all categories. A reduced trend in survival was observed for 18-34 years patients in the MELD era compared with the pre-MELD era, with 5-year intention-to-treat, overall and graft survival of 56.5%, 57.9%, 56.3% vs. 56.4%, 69.7%, 64.4% (P = 0.604, 0.034, and 0.071, respectively). For other age categories, survival rates were all superior in the MELD era. Cox-regression analysis showed values of hazard ratio for age increased with advanced age (all >1) in the pre-MELD era compared with the reference group (18-34 years), while these hazard ratios were liver allocation may adversely affect survival of specific HCV patients. © 2017 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

  15. Effect of PKC-β Signaling Pathway on Expression of MCP-1 and VCAM-1 in Different Cell Models in Response to Advanced Glycation End Products (AGEs

    Directory of Open Access Journals (Sweden)

    Lisienny C. T. Rempel

    2015-05-01

    Full Text Available Advanced glycation end products (AGEs are compounds classified as uremic toxins in patients with chronic kidney disease that have several pro-inflammatory effects and are implicated in the development of cardiovascular diseases. To explore the mechanisms of AGEs–endothelium interactions through the receptor for AGEs (RAGE in the PKC-β pathway, we evaluated the production of MCP-1 and VCAM-1 in human endothelial cells (HUVECs, monocytes, and a coculture of both. AGEs were prepared by albumin glycation and characterized by absorbance and electrophoresis. The effect of AGEs on cell viability was assessed with an MTT assay. The cells were also treated with AGEs with and without a PKC-β inhibitor. MCP-1 and VCAM-1 in the cell supernatants were estimated by ELISA, and RAGE was evaluated by immunocytochemistry. AGEs exposure did not affect cell viability, but AGEs induced RAGE, MCP-1, and VCAM-1 expression in HUVECs. When HUVECs or monocytes were incubated with AGEs and a PKC-β inhibitor, MCP-1 and VCAM-1 expression significantly decreased. However, in the coculture, exposure to AGEs and a PKC-β inhibitor produced no significant effect. This study demonstrates, in vitro, the regulatory mechanisms involved in MCP-1 production in three cellular models and VCAM-1 production in HUVECs, and thus mimics the endothelial dysfunction caused by AGEs in early atherosclerosis. Such mechanisms could serve as therapeutic targets to reduce the harmful effects of AGEs in patients with chronic kidney disease.

  16. Predictive accuracy of model for end stage liver disease (meld) as a prognostic marker for cirrhosis in comparison with child - pugh score

    International Nuclear Information System (INIS)

    Zubair, U.B.; Alam, M.M.; Saeed, F.

    2015-01-01

    To compare Model for End Stage Liver Disease (MELD) and Child-Turcott-Pugh (CTG) scoring as predictors of survival in cirrhotic patients. Study Design: Observational prospective study. Place and Duration of Study: Military Hospital, Rawalpindi from 1st Dec 2008 to 30th April 2009. Material and Methods: The study was carried out at Military Hospital, Rawalpindi a tertiary care hospital of Pakistan. Study included 55 patients suffering from cirrhosis of both genders being above 12 years of age, admitted in medical wards during the period from 1st December, 2008 to 30th April 2009. Each patient was assigned a MELD and CTP score. On discharge, these patients were followed up at 03 months, 06 months and 1 year duration through telephone. Results: Thirty seven (67.3%) patients were male while 18 (32.7%) were female patients, with age ranging from 27 years to 75 years (mean 53). Fourteen (25.4%) patients were dead at 3-months, 22 patients (40%) were dead at 6-months and 29 (52.7%) patients were dead at 1 year follow up. MELD score proved to be a better indicator of survival than CTP score over a period of 01 year follow-up. Conclusion: MELD score is a better prognostic marker for cirrhotic patients as compared to CTP score. (author)

  17. The effect of positive-end expiratory pressure on oxygenation during high frequency jet ventilation and conventional mechanical ventilation in the rabbit model of acute lung injury.

    Science.gov (United States)

    Bang, Jae Ouk; Ha, Seung Il; Choi, In-Cheol

    2012-10-01

    The use of positive end expiratory pressure (PEEP) in patients with acute lung injury (ALI) improves arterial oxygenation by alleviating pulmonary shunting, helping the respiratory muscles to decrease the work of breathing, decreasing the rate of infiltrated and atelectatic tissues, and increasing functional residual capacity. In a rabbit model of saline lavage-induced ALI, we examined the effects of PEEP on gas exchange, hemodynamics, and oxygenation during high frequency jet ventilation (HFJV), and then compared these parameters with those during conventional mechanical ventilation (CMV). Twelve rabbits underwent repeated saline lavage to create ALI. The animals were divided in 2 groups: 1) Group CMV (n = 6), and 2) Group HFJV (n = 6). In both groups, we applied 2 levels of PEEP (5 cmH(2)O and 10 cmH(2)O) and then measured the arterial blood gas, mixed venous blood gas, and hemodynamic parameters. With administration of PEEP of either 5 cmH(2)O or 10 cmH(2)O, the arterial oxygen content of both groups was increased, although without statistically significant differences between groups. On the contrary, the arterial carbon dioxide content was significantly decreased in the HFJV group, as compared with the CMV group, during the entire experiment. Furthermore, there was significant decreases in mean arterial pressures in both groups with a PEEP of 10 cmH(2)O. The application of PEEP in rabbits with ALI effectively improves oxygenation in either HFJV or CMV.

  18. Design of a Front– End Amplifier for the Maximum Power Delivery and Required Noise by HBMO with Support Vector Microstrip Model

    Directory of Open Access Journals (Sweden)

    F. Guneş

    2014-04-01

    Full Text Available Honey Bee Mating Optimization (HBMO is a recent swarm-based optimization algorithm to solve highly nonlinear problems, whose based approach combines the powers of simulated annealing, genetic algorithms, and an effective local search heuristic to search for the best possible solution to the problem under investigation within a reasonable computing time. In this work, the HBMO- based design is carried out for a front-end amplifier subject to be a subunit of a radar system in conjunction with a cost effective 3-D SONNET-based Support Vector Regression Machine (SVRM microstrip model. All the matching microstrip widths, lengths are obtained on a chosen substrate to satisfy the maximum power delivery and the required noise over the required bandwidth of a selected transistor. The proposed HBMO- based design is applied to the design of a typical ultra-wide-band low noise amplifier with NE3512S02 on a substrate of Rogers 4350 for the maximum output power and the noise figure F(f=1dB within the 5-12 GHz using the T- type of microstrip matching circuits. Furthermore, the effectiveness and efficiency of the proposed HBMO based design are manifested by comparing it with the Genetic Algorithm (GA, Particle Swarm Optimization (PSO and the simple HBMO based designs.

  19. Receptor for advanced glycation end products involved in lung ischemia reperfusion injury in cardiopulmonary bypass attenuated by controlled oxygen reperfusion in a canine model.

    Science.gov (United States)

    Rong, Jian; Ye, Sheng; Liang, Meng-ya; Chen, Guang-xian; Liu, Hai; Zhang, Jin-Xin; Wu, Zhong-kai

    2013-01-01

    Controlled oxygen reperfusion could protect the lung against ischemia-reperfusion injury in cardiopulmonary bypass (CPB) by downregulating high mobility group box 1 (HMGB1), a high affinity receptor of HMGB1. This study investigated the effect of controlled oxygen reperfusion on receptor for advanced glycation end products (RAGE) expression and its downstream effects on lung ischemia-reperfusion injury. Fourteen canines received CPB with 60 minutes of aortic clamping and cardioplegic arrest followed by 90 minutes of reperfusion. Animals were randomized to receive 80% FiO2 during the entire procedure (control group) or to a test group receiving a controlled oxygen reperfusion protocol. Pathologic changes in lung tissues, RAGE expression, serum interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were evaluated. The lung pathologic scores after 25 and 90 minutes of reperfusion were significantly lower in the test group compared with the control group (p RAGE expression, TNF-α, and IL-6 were downregulated by controlled oxygen treatment (p RAGE might be involved in the lung ischemia-reperfusion injury in canine model of CPB, which was downregulated by controlled oxygen reperfusion.

  20. Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration

    Directory of Open Access Journals (Sweden)

    Kamil Kruczek

    2017-06-01

    Full Text Available The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy. Here, we characterize cone differentiation in retinas derived from mouse embryonic stem cells (mESCs. Similar to in vivo development, a temporal pattern of progenitor marker expression is followed by the differentiation of early thyroid hormone receptor β2-positive precursors and, subsequently, photoreceptors exhibiting cone-specific phototransduction-related proteins. We establish that stage-specific inhibition of the Notch pathway increases cone cell differentiation, while retinoic acid signaling regulates cone maturation, comparable with their actions in vivo. MESC-derived cones can be isolated in large numbers and transplanted into adult mouse eyes, showing capacity to survive and mature in the subretinal space of Aipl1−/− mice, a model of end-stage retinal degeneration. Together, this work identifies a robust, renewable cell source for cone replacement by purified cell suspension transplantation.

  1. Nonlinearity of mechanical damping and stiffness of a spring-suspended sectional model system for wind tunnel tests

    Science.gov (United States)

    Gao, Guangzhong; Zhu, Ledong

    2015-10-01

    The wind tunnel test of spring-suspended sectional models (SSSM) is an important means in the research of wind engineering, which is very frequently employed to check the performances of flutter and vortex-induced resonance of bridges as well as to identify the various aerodynamic and aeroelastic parameters of bridge components, such as aerodynamic derivatives of self-excited forces. However, in practice, the mechanical damping ratios and natural frequencies of SSSM system are prevailingly supposed to be constant in the whole procedure of a test. This assumption often leads to notable errors of the test results or dispersion of the identified aerodynamic parameters because the mechanical damping ratios and natural frequencies of SSSM system are proved to vary in fact to some extent with the change of oscillating amplitude. On that account, the mechanical nonlinearity of SSSM system is investigated and discussed in this paper by taking a flat-closed box section as a research background. The conventional linear model is firstly proved to fail to predict precisely the long-duration free decay responses of the SSSM system. The formulae of equivalent linearization approximation (ELA) are then derived by using a multiple-scale method to model the mechanical nonlinearities in the first-order approximate sense, and a time-domain system identification method is proposed on this basis to identify equivalent amplitude-dependent (EAD) damping ratio and frequency. The proposed ELA and nonlinear system identification methods are then found to be precise enough to model the mechanical nonlinearities of SSSM system. The characteristics of EAD damping ratio and frequency of both the bending and torsional modes are then discussed in detail. It is then found that the major energy dissipation of SSSM vibrations at both the bending and torsional modes generally comes from the combined effect of viscous damping and quadratic damping. However, for the vibration at the bending mode with

  2. Model for End-stage Liver Disease and Organ Allocation in Liver Transplantation: Where Are We and Where Should We Go?

    Directory of Open Access Journals (Sweden)

    Teh-Ia Huo

    2006-05-01

    Full Text Available The Child-Turcotte-Pugh (CTP score has been used for decades to measure the severity of chronic liver disease. Recent studies have shown that the model for end-stage liver disease (MELD more accurately predicts the short-and mid-term survival for patients with cirrhosis compared to the CTP system. MELD, which has 3 parameters (serum bilirubin, creatinine, and prothrombin time that need logarithmic transformation, has the advantage of a wide-range continuous scale and is more objective and less variable. The liver allocation system has changed from a status-based algorithm using the CTP score, to one using a continuous MELD severity score as a reference system to prioritize adult patients on the waiting list since 2002 in the USA. However, there are potential limitations of MELD. An intrinsic defect is that some important parameters, such as hepatic encephalopathy and ascites, which are common adverse complications in cirrhosis, are not included in MELD. It has been suggested to incorporate a low serum sodium level into the prognostic model to enhance the predictive ability. Moreover, the change of MELD over time may provide updated information for patients on the transplant waiting list. In summary, although there was encouraging evidence supporting the prognostic advantage of MELD, the optimal role of MELD in the setting of outcome assessment for cirrhotic patients needs more study. Appropriate modifications and fine tuning of MELD are necessary for determining the ranking status of patients on the waiting list, to avoid a futile transplantation and improve overall patient survival.

  3. Model for end-stage liver disease (MELD score as a predictor and monitor of mortality in patients with Vibrio vulnificus necrotizing skin and soft tissue infections.

    Directory of Open Access Journals (Sweden)

    Kuo-Chin Huang

    2015-04-01

    Full Text Available Vibrio vulnificus necrotizing skin and soft tissue infections (VNSSTIs usually predispose patients with or without preexisting liver disease to septic shock, and then evolve to multiple organ dysfunction syndrome (MODS, thus resulting in high mortality in humans. However, clinicians do not have a valid prediction model to provide a reliable estimate of case-fatality rate when caring for these acutely and/or critically ill patients.We retrospectively analyzed 39 consecutive patients with VNSSTIs (mean age: 65.7 ± 11.3 years at our institution between 2007 and 2010. All patients were treated with the same protocol. Demographic and clinical characteristics, disease severity on admission, treatment details, and outcomes were collected for each patient and extracted for analyses. We studied the predictive value of the model for end-stage liver disease (MELD, modified MELD including sodium (MELD-Na, and laboratory risk indicator for necrotizing fasciitis (LRINEC scores for case-fatality. Logistic regression and receiver operating characteristic (ROC curve analyses were performed. The mean MELD, MELD-Na and LRINEC scores on admission were 15.1 ± 1.1, 17.7 ± 1.1, and 3.4 ± 0.4 points, respectively. After admission, these patients had temporary or progressive deterioration of nearly all their scores and lab values. The area under the ROC curve for the MELD and ΔMELD scoring models were 0.929 (p = 0.002 and 0.897 (p = 0.005, respectively. An optimal MELD/ΔMELD cutoff value ≥ 20/2 had a good sensitivity and specificity (all > 80%, with a 64/13-fold increased odds for case-fatality. Additionally, the development of severe forms of anemia (p = 0.014 and hypoalbuminemia (p = 0.019 were associated with an increased case-fatality rate.The MELD/ΔMELD scoring model is an effective risk stratification indicator at the time of admission and also an excellent condition monitor during hospitalization for medical care of acutely and/or critically ill patients

  4. Endüstriyel İşletmelerde Franchising Model Önerisi: Hazır Beton Sektöründe Bir Uygulama

    Directory of Open Access Journals (Sweden)

    İpek Kazançoğlu

    2016-12-01

    Full Text Available Endüstriyel pazarda faaliyet gösteren firmaların daha hızlı büyüyerek, yeni pazarlara açılmasında franchising sistemi bir yeni bir satış, dağıtım kanalı olarak değerlendirilmektedir. Bu araştırmada amaç,  hazır beton sektöründe faaliyet gösteren bir firmanın franchising sistemini bir iş modeli olarak benimseme kararında dikkat etmesi gereken unsurları ve karşılaşılan zorlukları incelemektedir. Örnek olay çalışması olarak ele alınan çalışmada,  BATIBETON A.Ş. firmasının yedi yöneticiyle BATIBETON markasının franchising uygulamalarına ilişkin görüşlerini öğrenmek amacıyla derinlemesine görüşmeler yapılmıştır. Bu görüşmeler sonucunda, franchising sisteminin hazır beton sektöründe bir model önerisi olarak uygulanıp/uygulanmayacağı değerlendirilmiştir. Yapılan görüşmelerden elde edilen bulguların diğer endüstriyel işletmeler içinde geliştirilebilecek bir franchising iş modeli kararında etkili olabilecek faktörlerin anlaşılması yönünden uygulamaya katkı sağlayacağı düşünülmektedir.

  5. Predicting Oral Health Behavior using the Health Promotion Model among School Students: a Cross-sectional Survey

    Directory of Open Access Journals (Sweden)

    Abdurrahman Charkazi

    2016-07-01

    Full Text Available teeth and T=permanent teeth has been increasing from 1957 to 2015 years in Iran. The current survey aimed to test the power of health promotion model for predicting the oral health behavior among high-school students.  Materials and Methods: A cross-sectional study was conducted on 482 high school students in Gorgan city, Iran. Multi-cluster sampling was used to recruit the samples. A researcher-made questionnaire based on HPM was implemented to collect data. To analyze, SPSS-18 and statistical tests, including t-test, Pearson correlation coefficient and univariate and multivariate regression models were used. Results: A total of 482 high-school students including 255 (52.9% male and 227 (47.1% with mean age of 16.02 ± 0.5 were investigated. The highest and lowest prevalent positive oral health behavior were tooth brushing (73% and using fluidized oral irrigator (3.6%, respectively. Except for perceived barriers (with negative correlation, all constructs of HBM were positively related to oral health behaviors. Self-efficacy was the strongest predictor of oral health behavior (β=0.653 (r=0.541, P

  6. Cross-sectional neck response of a total human body FE model during simulated frontal and side automobile impacts.

    Science.gov (United States)

    White, Nicholas A; Moreno, Daniel P; Gayzik, F Scott; Stitzel, Joel D

    2015-01-01

    Human body finite element (FE) models are beginning to play a more prevalent role in the advancement of automotive safety. A methodology has been developed to evaluate neck response at multiple levels in a human body FE model during simulated automotive impacts. Three different impact scenarios were simulated: a frontal impact of a belted driver with airbag deployment, a frontal impact of a belted passenger without airbag deployment and an unbelted side impact sled test. Cross sections were created at each vertebral level of the cervical spine to calculate the force and moment contributions of different anatomical components of the neck. Adjacent level axial force ratios varied between 0.74 and 1.11 and adjacent level bending moment ratios between 0.55 and 1.15. The present technique is ideal for comparing neck forces and moments to existing injury threshold values, calculating injury criteria and for better understanding the biomechanical mechanisms of neck injury and load sharing during sub-injurious and injurious loading.

  7. The effect of changes of model for end-stage liver disease score during waiting time on post-liver transplant mortality.

    Science.gov (United States)

    Al-Freah, Mohammad A B; Gane, Edward J; Livingstone, Vicki; McCall, John; Munn, Stephen

    2012-04-01

    Model for End-Stage Liver Disease (MELD) score is found to be a robust predictor of mortality while on waiting list for liver transplantation. However, studies have shown inconsistent results for transplant MELD as a predictor of posttransplant mortality. To find whether utilization of MELD at listing, at transplant, or Δ MELD while waiting can predict outcome at a national transplant center, which is not part of an organ sharing network. Retrospective analysis of patients listed for liver transplantation at the New Zealand Liver Transplant Unit (NZLTU) with calculation of MELD score at the time of listing and at transplant with/without adjustment points for hepatocellular carcinoma (HCC). Between 1998 and 2005, 264 adult patients were listed for liver transplantation. Median age at transplant was 49 years (range 16-70) and 65% were male. The most common etiology was viral hepatitis (50%). A total of 48 patients (20%) had known HCC. MELD scores (adjusted and nonadjusted) at listing and at transplantation were similar across all primary liver diseases (P = 0.88, 0.93, respectively). Adjusted MELD scores were significantly higher in patients listed for HCC compared to those without HCC (P 1 point or less (P = 0.67). Waiting time does not appear to influence posttransplant survival (P = 0.75). In a country with a single transplant center and organ retrieval organization, the addition of MELD score to current minimal listing criteria does not improve prioritization of patients on the waiting list or predict posttransplant survival. Also, adjusting MELD score for HCC would unfairly disadvantage patients listed without HCC.

  8. Efficacy of chest compressions directed by end-tidal CO2 feedback in a pediatric resuscitation model of basic life support.

    Science.gov (United States)

    Hamrick, Jennifer L; Hamrick, Justin T; Lee, Jennifer K; Lee, Benjamin H; Koehler, Raymond C; Shaffner, Donald H

    2014-04-14

    End-tidal carbon dioxide (ETCO2) correlates with systemic blood flow and resuscitation rate during cardiopulmonary resuscitation (CPR) and may potentially direct chest compression performance. We compared ETCO2-directed chest compressions with chest compressions optimized to pediatric basic life support guidelines in an infant swine model to determine the effect on rate of return of spontaneous circulation (ROSC). Forty 2-kg piglets underwent general anesthesia, tracheostomy, placement of vascular catheters, ventricular fibrillation, and 90 seconds of no-flow before receiving 10 or 12 minutes of pediatric basic life support. In the optimized group, chest compressions were optimized by marker, video, and verbal feedback to obtain American Heart Association-recommended depth and rate. In the ETCO2-directed group, compression depth, rate, and hand position were modified to obtain a maximal ETCO2 without video or verbal feedback. After the interval of pediatric basic life support, external defibrillation and intravenous epinephrine were administered for another 10 minutes of CPR or until ROSC. Mean ETCO2 at 10 minutes of CPR was 22.7±7.8 mm Hg in the optimized group (n=20) and 28.5±7.0 mm Hg in the ETCO2-directed group (n=20; P=0.02). Despite higher ETCO2 and mean arterial pressure in the latter group, ROSC rates were similar: 13 of 20 (65%; optimized) and 14 of 20 (70%; ETCO2 directed). The best predictor of ROSC was systemic perfusion pressure. Defibrillation attempts, epinephrine doses required, and CPR-related injuries were similar between groups. The use of ETCO2-directed chest compressions is a novel guided approach to resuscitation that can be as effective as standard CPR optimized with marker, video, and verbal feedback.

  9. DNA Advanced Glycation End Products (DNA-AGEs) Are Elevated in Urine and Tissue in an Animal Model of Type 2 Diabetes.

    Science.gov (United States)

    Jaramillo, Richard; Shuck, Sarah C; Chan, Yin S; Liu, Xueli; Bates, Steven E; Lim, Punnajit P; Tamae, Daniel; Lacoste, Sandrine; O'Connor, Timothy R; Termini, John

    2017-02-20

    More precise identification and treatment monitoring of prediabetic/diabetic individuals will require additional biomarkers to complement existing diagnostic tests. Candidates include hyperglycemia-induced adducts such as advanced glycation end products (AGEs) of proteins, lipids, and DNA. The potential for DNA-AGEs as diabetic biomarkers was examined in a longitudinal study using the Lepr db/db animal model of metabolic syndrome. The DNA-AGE, N 2 -(1-carboxyethyl)-2'-deoxyguanosine (CEdG) was quantified by mass spectrometry using isotope dilution from the urine and tissue of hyperglycemic and normoglycemic mice. Hyperglycemic mice (fasting plasma glucose, FPG, ≥ 200 mg/dL) displayed a higher median urinary CEdG value (238.4 ± 112.8 pmol/24 h) than normoglycemic mice (16.1 ± 11.8 pmol/24 h). Logistic regression analysis revealed urinary CEdG to be an independent predictor of hyperglycemia. Urinary CEdG was positively correlated with FPG in hyperglycemic animals and with HbA1c for all mice. Average tissue-derived CEdG was also higher in hyperglycemic mice (18.4 CEdG/10 6 dG) than normoglycemic mice (4.4 CEdG/10 6 dG). Urinary CEdG was significantly elevated in Lepr db/db mice relative to Lepr wt/wt , and tissue CEdG values increased in the order Lepr wt/wt < Lepr wt/db < Lepr db/db . These data suggest that urinary CEdG measurement may provide a noninvasive quantitative index of glycemic status and augment existing biomarkers for the diagnosis and monitoring of diabetes.

  10. Development and Pilot Evaluation of a Novel Dignity-Conserving End-of-Life (EoL) Care Model for Nursing Homes in Chinese Societies.

    Science.gov (United States)

    Ho, Andy H Y; Dai, Annie A N; Lam, Shu-Hang; Wong, Sandy W P; Tsui, Amy L M; Tang, Jervis C S; Lou, Vivian W Q

    2016-06-01

    The provision of end-of-life (EoL) care in long-term-care settings remains largely underdeveloped in most Chinese societies, and nursing home residents often fail to obtain good care as they approach death. This paper systematically describes the development and implementation mechanisms of a novel Dignity-Conserving EoL Care model that has been successfully adopted by three nursing homes in Hong Kong and presents preliminary evidence of its effectiveness on enhancing dignity and quality of life (QoL) of terminally ill residents. Nine terminally ill nursing home residents completed the McGill Quality of Life Questionnaire and the Nursing Facilities Quality of Life Questionnaire at baseline and 6 months post-EoL program enrollment. Wilcoxon signed rank test was used to detect significance changes in each QoL domains across time. Although significant deterioration was recorded for physical QoL, significant improvement was observed for social QoL. Moreover, a clear trend toward significant improvements was identified for the QoL domains of individuality and relationships. A holistic and compassionate caring environment, together with the core principles of family-centered care, interagency and interdisciplinary teamwork, as well as cultural-specific psycho-socio-spiritual support, are all essential elements for optimizing QoL and promoting death with dignity for nursing home residents facing morality. This study provides a useful framework to facilitate the future development of EoL care in long-term-care settings in the Chinese context. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Liver dysfunction assessed by model for end-stage liver disease excluding INR (MELD-XI scoring system predicts adverse prognosis in heart failure.

    Directory of Open Access Journals (Sweden)

    Satoshi Abe

    Full Text Available AIMS: Liver dysfunction due to heart failure (HF is often referred to as cardiac or congestive hepatopathy. The composite Model for End-Stage Liver Disease excluding INR (MELD-XI is a robust scoring system of liver function, and a high score is associated with poor prognosis in advanced HF patients with a heart transplantation and/or ventricular assist device. However, the impact of MELD-XI on the prognosis of HF patients in general remains unclear. METHODS AND RESULTS: We retrospectively analyzed 562 patients who were admitted to our hospital for the treatment of decompensated HF. A MELD-XI score was graded, and patients were divided into two groups based on the median value of MELD-XI score: Group L (MELD-XI <10, n = 289 and Group H (MELD-XI ≥10, n = 273. We compared all-cause mortality and echocardiographic findings between the two groups. In the follow-up period (mean 471 days, 104 deaths (62 cardiac deaths and 42 non-cardiac deaths were observed. The event (cardiac death, non-cardiac death, all-cause death-free rate was significantly higher in group L than in group H (logrank P<0.05, respectively. In the Cox proportional hazard analysis, a high MELD-XI score was found to be an independent predictor of cardiac deaths and all-cause mortality in HF patients. Regarding echocardiographic parameters, right atrial and ventricular areas, inferior vena cava diameter, and systolic pulmonary artery pressure were higher in group H than in group L (P<0.05, respectively. CONCLUSIONS: The MELD-XI scoring system, a marker of liver function, can identify high-risk patients with right heart volume overload, higher pulmonary arterial pressure and multiple organ failure associated with HF.

  12. Identification of the main processes underlying ecosystem functioning in the Eastern English Channel, with a focus on flatfish species, as revealed through the application of the Atlantis end-to-end model

    Science.gov (United States)

    Girardin, Raphaël; Fulton, Elizabeth A.; Lehuta, Sigrid; Rolland, Marie; Thébaud, Olivier; Travers-Trolet, Morgane; Vermard, Youen; Marchal, Paul

    2018-02-01

    The ecosystem model Atlantis was used to investigate the key dynamics and processes that structure the Eastern English Channel ecosystem, with a particular focus on two commercial flatfish species, sole (Solea solea) and plaice (Pleuronectes platessa). This complex model was parameterized with data collected from diverse sources (a literature review, survey data, as well as landings and stock assessment information) and tuned so both simulated biomass and catch fit 2002-2011 observations. Here, the outputs are mainly presented for the two focus species and for some other vertebrates found to be important in the trophic network. The calibration process revealed the importance of coastal areas in the Eastern English Channel and of nutrient inputs from estuaries: a lack of river nutrients decreases the productivity of nursery grounds and adversely affects the production of sole and plaice. The role of discards in the trophic network is also highlighted. While sole and plaice did not have a strong influence on the trophic network of vertebrates, they are important predators for benthic invertebrates and compete for food with crustaceans, whiting (Merlangius merlangus) and other demersal fish. We also found that two key species, cod (Gadus morhua) and whiting, thoroughly structured the Eastern English Channel trophic network.

  13. Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood–brain barrier models for the study of T cell extravasation

    Science.gov (United States)

    Steiner, Oliver; Coisne, Caroline; Engelhardt, Britta; Lyck, Ruth

    2011-01-01

    Important insights into the molecular mechanism of T cell extravasation across the blood–brain barrier (BBB) have already been obtained using immortalized mouse brain endothelioma cell lines (bEnd). However, compared with bEnd, primary brain endothelial cells have been shown to establish better barrier characteristics, including complex tight junctions and low permeability. In this study, we asked whether bEnd5 and primary mouse brain microvascular endothelial cells (pMBMECs) were equally suited as in vitro models with which to study the cellular and molecular mechanisms of T cell extravasation across the BBB. We found that both in vitro BBB models equally supported both T cell adhesion under static and physiologic flow conditions, and T cell crawling on the endothelial surface against the direction of flow. In contrast, distances of T cell crawling on pMBMECs were strikingly longer than on bEnd5, whereas diapedesis of T cells across pMBMECs was dramatically reduced compared with bEnd5. Thus, both in vitro BBB models are suited to study T cell adhesion. However, because pMBMECs better reflect endothelial BBB specialization in vivo, we propose that more reliable information about the cellular and molecular mechanisms of T cell diapedesis across the BBB can be attained using pMBMECs. PMID:20606687

  14. Reoperative complications after primary orthotopic liver transplantation: a contemporary single-center experience in the post-model for end-stage liver disease era.

    Science.gov (United States)

    DiNorcia, Joseph; Lee, Minna K; Harlander-Locke, Michael; Zarrinpar, Ali; Kaldas, Fady M; Yersiz, Hasan; Farmer, Douglas G; Hiatt, Jonathan R; Busuttil, Ronald W; Agopian, Vatche G

    2014-11-01

    Data on complications requiring reoperation after orthotopic liver transplantation (OLT) are limited. We sought to describe the spectrum of reoperative complications after OLT, evaluate the associations with graft and patient survival, and identify predictors of need for reoperation. We retrospectively studied adult patients who underwent primary OLT at our institution from February 2002 to July 2012. The primary outcomes included occurrence of a reoperative complication. Secondary outcomes were graft and patient survival. Multivariable logistic regression analysis was used to model the associations of recipient, donor, and operative variables with reoperation. Of 1,620 patients, 470 (29%) had complications requiring reoperation. The most common reoperative complication was bleeding (17.3%). Compared with patients not requiring reoperation, patients with reoperative complications had greater Model for End-Stage Liver Disease scores and need for pretransplantation hospitalization, mechanical ventilation, vasopressors, and renal replacement therapy; considerably longer cold and warm ischemia times and greater intraoperative blood transfusion requirements; and substantially worse 1-, 3-, and 5-year graft and patient survival rates. In multivariable analysis, predictors of reoperative complications included intraoperative transfusion of packed RBCs (odds ratio [OR] = 2.21; 95% CI, 1.91-2.56), donor length of hospitalization >8 days (OR = 1.87; 95% CI, 1.28-2.73), recipient pretransplantation mechanical ventilation (OR = 1.65; 95% CI, 1.21-2.24), cold ischemia time >9 hours (OR = 1.63; 95% CI, 1.23-2.17), warm ischemia time >55 minutes (OR = 1.58; 95% CI, 1.02-2.44), earlier major abdominal surgery (OR = 1.41; 95% CI, 1.03-1.92), and elevated donor serum sodium (OR = 1.17; 95% CI, 1.03-1.31). Patients who require reoperation for complications after OLT have high pretransplantation acuity and inferior post-transplantation survival. We identified factors associated

  15. Pneumatic inflatable end effector

    Science.gov (United States)

    Clark, K. H.; Johnston, J. D. (Inventor)

    1981-01-01

    The invention relates to an end effector device for robot or teleoperated type space vehicle which includes an inflatable balloon member carried on the end of tubular member which has a hollow center or conduit through which a suitable pressurized fluid is supplied. The device may be inserted into a variety of shaped openings or truss-type structures for handling in space.

  16. Means-End Relations

    NARCIS (Netherlands)

    J. van Rekom (Johan); B. Wierenga (Berend)

    2002-01-01

    textabstractMeans-end relations are generally assumed to be hierarchical, and, by implication, asymmetrical. That is, if A is a means to achieve B, B is not at the same time also a means to achieve A. Literature casting doubt on this directedness of means-end relations is reviewed, and the

  17. Penalty model for delay of bidding section construction period in South-to-North Water Diversion Eastern Route Project from perspective of programs

    Directory of Open Access Journals (Sweden)

    Jing-chun Feng

    2012-09-01

    Full Text Available According to the multi-project and program management theory, this paper analyzes the program generation principle and establishes a program based on progress goals. On the basis of the present situation of calculation of penalty for delay of the bidding section construction period with the critical path method, we studied the effects of contractor-induced delay of the bidding section construction period in detail, including the effects on the construction period of the bidding section itself, the earliest start times of the next bidding section and other subsequent bidding sections, and the construction period of the program, and then constructed a penalty model for delay of the bidding section construction period from the perspective of programs. Using the penalty model, we conducted a practical analysis of penalty for delay of the construction period of the Baoying station program in the South-to-North Water Diversion Project. The model can help determine the amount of penalty for delay of the construction period in bidding sections scientifically and reasonably.

  18. Older patients' consultations in an apprenticeship model-based general practice training program: A cross-sectional study.

    Science.gov (United States)

    Bonney, Andrew; Morgan, Simon; Tapley, Amanda; Henderson, Kim; Holliday, Elizabeth; Davey, Andrew; van Driel, Mieke; Spike, Neil; Regan, Cathy; Ball, Jean; Magin, Parker

    2017-03-01

    To investigate older patients' encounters with general practice registrars (GPRs) to inform training and clinical practice. Cross-sectional analysis of data from GPR consultations across five regional training providers in Australia. Data were analysed using simple and multiple logistic regression models. Our analysis included details of 118 831 consultations, 20 555 (17.6%, 95% CI 17.4-17.8) with patients aged ≥65 years. Older patient encounters had an increased likelihood of including chronic disease (OR 1.77, 95% CI 1.70, 1.86) and more problems (OR 1.24, 95% CI 1.20, 1.27). However, in-consultation information or advice was less likely to be sought (OR 0.92, 95% CI 0.88, 0.97), and consultations were briefer (OR 0.99, 95% CI 0.99, 1.00). Our results suggest relatively limited GPR exposure to older patients coupled with less complex consultations than expected. Solutions will need to be carefully constructed not only to increase caseloads, but also to address training and supervision concerns. © 2016 AJA Inc.

  19. Smoking Status and the Five-Factor Model of Personality: Results of a Cross-Sectional Study Conducted in Poland

    Directory of Open Access Journals (Sweden)

    Krzysztof Buczkowski

    2017-01-01

    Full Text Available Tobacco smoking is the single most important modifiable factor in increased morbidity and premature mortality. Numerous factors—including genetics, personality, and environment—affect the development and persistence of tobacco addiction, and knowledge regarding these factors could improve smoking cessation rates. This study compared personality traits between never, former, and current smokers, using the Five-Factor Model of Personality in a country with a turbulent smoking reduction process.: In this cross-sectional study, 909 Polish adults completed the Revised Neuroticism-Extraversion-Openness Personality Inventory. Our results showed that current smokers’ scores for extraversion, one of the five global dimensions of personality, were higher relative to never smokers. Neuroticism, openness to experience, agreeableness, and conscientiousness did not differ significantly according to smoking status. Facet analysis, which described each dimension in detail, showed that current smokers’ activity and excitement seeking (facets of extraversion scores were higher relative to those of never and former smokers. In turn, current smokers’ dutifulness and deliberation (facets of conscientiousness scores were lower than those found in former and never smokers. Never smokers scored the highest in self-consciousness (a facet of neuroticism and compliance (a component of agreeableness. The study conducted among Polish individuals showed variation in personality traits according to their smoking status; however, this variation differed from that reported in countries in which efforts to reduce smoking had begun earlier relative to Poland. Knowledge regarding personality traits could be useful in designing smoking prevention and cessation programs tailored to individuals’ needs.

  20. Smoking Status and the Five-Factor Model of Personality: Results of a Cross-Sectional Study Conducted in Poland.

    Science.gov (United States)

    Buczkowski, Krzysztof; Basinska, Małgorzata A; Ratajska, Anna; Lewandowska, Katarzyna; Luszkiewicz, Dorota; Sieminska, Alicja

    2017-01-27

    Tobacco smoking is the single most important modifiable factor in increased morbidity and premature mortality. Numerous factors-including genetics, personality, and environment-affect the development and persistence of tobacco addiction, and knowledge regarding these factors could improve smoking cessation rates. This study compared personality traits between never, former, and current smokers, using the Five-Factor Model of Personality in a country with a turbulent smoking reduction process. : In this cross-sectional study, 909 Polish adults completed the Revised Neuroticism-Extraversion-Openness Personality Inventory. Our results showed that current smokers' scores for extraversion, one of the five global dimensions of personality, were higher relative to never smokers. Neuroticism, openness to experience, agreeableness, and conscientiousness did not differ significantly according to smoking status. Facet analysis, which described each dimension in detail, showed that current smokers' activity and excitement seeking (facets of extraversion) scores were higher relative to those of never and former smokers. In turn, current smokers' dutifulness and deliberation (facets of conscientiousness) scores were lower than those found in former and never smokers. Never smokers scored the highest in self-consciousness (a facet of neuroticism) and compliance (a component of agreeableness). The study conducted among Polish individuals showed variation in personality traits according to their smoking status; however, this variation differed from that reported in countries in which efforts to reduce smoking had begun earlier relative to Poland. Knowledge regarding personality traits could be useful in designing smoking prevention and cessation programs tailored to individuals' needs.

  1. High energy neutron cross-sections and kerma values of biomedical interest calculated with a nuclear model applicable to light nuclei

    International Nuclear Information System (INIS)

    Brenner, D.J.

    1984-01-01

    A model has been developed for calculating fast neutron cross sections (E > 14 MeV) for light nuclei of biomedical interest. The model explicitly includes experimental nuclear structure information. Some calculations for 12 C, 14 N, and 16 O are presented

  2. End-to-End Availability Analysis of IMS-Based Networks

    DEFF Research Database (Denmark)

    Kamyod, Chayapol; Nielsen, Rasmus Hjorth; Prasad, Neeli R.

    2013-01-01

    -of-the-art models are compared with the proposed novel Markov-based reliability modeling for both simplex and redundant systems. The proposed model is proved to efficiently represent the system behaviors. The effect of the end-to-end availability model when applying redundancy in the IMS core system is investigated......Various methods and models have recently been proposed and applied for evaluating IP Multimedia Subsystem (IMS) in terms of reliability, availability and performance. End-to-end availability is one of the key factors that can improve the quality of service (QoS) and increase the reliability of Next...

  3. Cesarean Section

    Science.gov (United States)

    A Cesarean section (C-section) is surgery to deliver a baby. The baby is taken out through the mother's ... are able to have a vaginal birth after cesarean (VBAC). NIH: National Institute of Child Health and ...

  4. The cross-section of returns, benchmark model parameters, and idiosyncratic volatility of nuclear energy firms after Fukushima Daiichi

    International Nuclear Information System (INIS)

    Lopatta, Kerstin; Kaspereit, Thomas

    2014-01-01

    This study analyzes how the stock market returns, the factor loadings from the Carhart (1997) 4-factor model, and the idiosyncratic volatility of shares in energy firms have been affected by the Fukushima nuclear accident. Unlike existing studies, which provide evidence of a wealth transfer from nuclear to renewable energy firms for specific countries, we use an international sample and investigate whether changes in the regulatory environment and the firm-specific commitment to nuclear and renewable energies correlate with the capital market's reactions to the Fukushima Daiichi accident. Our findings suggest that the more a firm relies on nuclear power, the more its share price declined after the accident. A commitment to renewable energies does not prevent declines in share prices but significantly helps to reduce the increase in market beta that is associated with this event. Nuclear energy firms domiciled in countries with a higher number of regulatory interventions that were triggered by the catastrophe have lower abnormal returns than those that are domiciled elsewhere. However, as a cross-sectional analysis reveals, a stronger commitment to nuclear power is the main driver for negative stock market returns. Furthermore, nuclear energy firms domiciled in countries with stronger regulatory shifts away from nuclear energy experience significant increases in market beta and the book-to-market equity factor loading according to the Carhart (1997) 4-factor model. We conclude that capital market participants are able to differentiate between the affectedness of firms with respect to their product portfolio. Energy firms could prevent increases in market beta due to catastrophes such as the Fukushima Daiichi accident by shifting some of their energy production from nuclear to renewable or other sources. - Highlights: • Abnormal stock returns of nuclear energy firms around Fukushima Daiichi depend on the mix of their energy portfolio. • Higher commitment to

  5. TROPOMI end-to-end performance studies

    Science.gov (United States)

    Voors, Robert; de Vries, Johan; Veefkind, Pepijn; Gloudemans, Annemieke; Mika, Àgnes; Levelt, Pieternel

    2008-10-01

    The TROPOspheric Monitoring Instrument (TROPOMI) is a UV/VIS/NIR/SWIR non-scanning nadir viewing imaging spectrometer that combines a wide swath (110°) with high spatial resolution (8 x 8 km). Its main heritages are from the Ozone Monitoring Instrument (OMI) and from SCIAMACHY. Since its launch in 2004 OMI has been providing, on a daily basis and on a global scale, a wealth of data on ozone, NO2 and minor trace gases, aerosols and local pollution, a scanning spectrometer launched in 2004. The TROPOMI UV/VIS/NIR and SWIR heritage is a combination of OMI and SCIAMACHY. In the framework of development programs for a follow-up mission for the successful Ozone Monitoring Instrument, we have developed the so-called TROPOMI Integrated Development Environment. This is a GRID based software simulation tool for OMI follow-up missions. It includes scene generation, an instrument simulator, a level 0-1b processing chain, as well as several level 1b-2 processing chains. In addition it contains an error-analyzer, i.e. a tool to feedback the level 2 results to the input of the scene generator. The paper gives a description of the TROPOMI instrument and focuses on design aspects as well as on the performance, as tested in the end-to-end development environment TIDE.

  6. Alveolar Tidal recruitment/derecruitment and Overdistension During Four Levels of End-Expiratory Pressure with Protective Tidal Volume During Anesthesia in a Murine Lung-Healthy Model.

    Science.gov (United States)

    Soares, Joao Henrique Neves; Carvalho, Alysson Roncally; Bergamini, Bruno Curty; Gress, Maria Alice Kuster; Jandre, Frederico Caetano; Zin, Walter Araujo; Giannella-Neto, Antonio

    2018-02-12

    We compared respiratory mechanics between the positive end-expiratory pressure of minimal respiratory system elastance (PEEP minErs ) and three levels of PEEP during low-tidal-volume (6 mL/kg) ventilation in rats. Twenty-four rats were anesthetized, paralyzed, and mechanically ventilated. Airway pressure (P aw ), flow (F), and volume (V) were fitted by a linear single compartment model (LSCM) P aw (t) = E rs  × V(t) + R rs  × F(t) + PEEP or a volume- and flow-dependent SCM (VFDSCM) P aw (t) = (E 1  + E 2  × V(t)) × V(t) + (K 1  + K 2  × |F(t)|) × F(t) + PEEP, where E rs and R rs are respiratory system elastance and resistance, respectively; E 1 and E 2 × V are volume-independent and volume-dependent E rs , respectively; and K 1 and K 2  × F are flow-independent and flow-dependent R rs , respectively. Animals were ventilated for 1 h at PEEP 0 cmH 2 O (ZEEP); PEEP minErs ; 2 cmH 2 O above PEEP minErs (PEEP minErs+2 ); or 4 cmH 2 O above PEEP minErs (PEEP minErs+4 ). Alveolar tidal recruitment/derecruitment and overdistension were assessed by the index %E 2  = 100 × [(E 2  × V T )/(E 1  + |E 2 | × V T )], and alveolar stability by the slope of E rs (t). %E 2 varied between 0 and 30% at PEEP minErs in most respiratory cycles. Alveolar Tidal recruitment/derecruitment (%E 2   30) were predominant in the absence of PEEP and in PEEP levels higher than PEEP minErs , respectively. The slope of E rs (t) was different from zero in all groups besides PEEP minErs+4 . PEEP minErs presented the best compromise between alveolar tidal recruitment/derecruitment and overdistension, during 1 h of low-V T mechanical ventilation.

  7. The challenge pathway: A mixed methods evaluation of an innovative care model for the palliative and end-of-life care of people with dementia (Innovative practice).

    Science.gov (United States)

    Harrop, Emily; Nelson, Annmarie; Rees, Helen; Harris, Dylan; Noble, Simon

    2018-02-01

    An innovative service for the palliative and end-of-life care of people with dementia was introduced at a UK hospice. This evaluation involved analysis of audit data, semi-structured interviews with project staff (n=3) and surveys of family carers (n=15) and professionals (n=20). The service has increased access to palliative, end-of-life care and other services. Improvements were reported in the knowledge, confidence and care skills of family carers and professionals. Carers felt better supported and it was perceived that the service enabled more patients to be cared for at home or in their usual place of care.

  8. Influence of suture technique and suture material selection on the mechanics of end-to-end and end-to-side anastomoses.

    Science.gov (United States)

    Baumgartner, N; Dobrin, P B; Morasch, M; Dong, Q S; Mrkvicka, R

    1996-05-01

    Experiments were performed in dogs to evaluate the mechanics of 26 end-to-end and 42 end-to-side artery-vein graft anastomoses constructed with continuous polypropylene sutures (Surgilene; Davis & Geck, Division of American Cyanamid Co., Danbury, Conn.), continuous polybutester sutures (Novafil; Davis & Geck), and interrupted stitches with either suture material. After construction, the grafts and adjoining arteries were excised, mounted in vitro at in situ length, filled with a dilute barium sulfate suspension, and pressurized in 25 mm Hg steps up to 200 mm Hg. Radiographs were obtained at each pressure. The computed cross-sectional areas of the anastomoses were compared with those of the native arteries at corresponding pressures. Results showed that for the end-to-end anastomoses at 100 mm Hg the cross-sectional areas of the continuous Surgilene anastomoses were 70% of the native artery cross-sectional areas, the cross-sectional areas of the continuous Novafil anastomoses were 90% of the native artery cross-sectional areas, and the cross-sectional areas of the interrupted anastomoses were 107% of the native artery cross-sectional areas (p anastomoses demonstrated no differences in cross-sectional areas or compliance for the three suture techniques. This suggests that, unlike with end-to-end anastomoses, when constructing an end-to-side anastomosis in patients any of the three suture techniques may be acceptable.

  9. Pressure Ulcer Prevalence and Care in Indonesian Hospitals: A Multicenter, Cross-sectional Evaluation Using an Extended Donabedian Model.

    Science.gov (United States)

    Amir, Yufitriana; Tan, Frans E S; Halfens, Ruud; Lohrmann, Christa; Schols, Jos

    2017-02-01

    Although