WorldWideScience

Sample records for modeling high intensity

  1. Modelling of radiation losses for ion acceleration at ultra-high laser intensities

    Directory of Open Access Journals (Sweden)

    Capdessus Remi

    2013-11-01

    Full Text Available Radiation losses of charged particles can become important in ultra high intensity laser plasma interaction. This process is described by the radiation back reaction term in the electron equation of motion. This term is implemented in the relativistic particle-in-cell code by using a renormalized Lorentz-Abraham-Dirac model. In the hole boring regime case of laser ion acceleration it is shown that radiation losses results in a decrease of the piston velocity.

  2. Modelling stock order flows with non-homogeneous intensities from high-frequency data

    Science.gov (United States)

    Gorshenin, Andrey K.; Korolev, Victor Yu.; Zeifman, Alexander I.; Shorgin, Sergey Ya.; Chertok, Andrey V.; Evstafyev, Artem I.; Korchagin, Alexander Yu.

    2013-10-01

    A micro-scale model is proposed for the evolution of such information system as the limit order book in financial markets. Within this model, the flows of orders (claims) are described by doubly stochastic Poisson processes taking account of the stochastic character of intensities of buy and sell orders that determine the price discovery mechanism. The proposed multiplicative model of stochastic intensities makes it possible to analyze the characteristics of the order flows as well as the instantaneous proportion of the forces of buyers and sellers, that is, the imbalance process, without modelling the external information background. The proposed model gives the opportunity to link the micro-scale (high-frequency) dynamics of the limit order book with the macro-scale models of stock price processes of the form of subordinated Wiener processes by means of limit theorems of probability theory and hence, to use the normal variance-mean mixture models of the corresponding heavy-tailed distributions. The approach can be useful in different areas with similar properties (e.g., in plasma physics).

  3. Discrete vortex model of a Helmholtz resonator subjected to high-intensity sound and grazing flow.

    Science.gov (United States)

    Dai, Xiwen; Jing, Xiaodong; Sun, Xiaofeng

    2012-11-01

    In this paper, a theoretical model is developed to study the acoustical response of a Helmholtz resonator as a duct-branched acoustic absorber subjected to both high-intensity sound and grazing flow. The present model is comprised of a discrete vortex model in combination with a one-dimensional duct sound propagation model. The present work is to study the overall effect of incident sound interacting with grazing flow but putting emphasis on the nonlinear or intermediate regime where the sound intensity has a marked or non-negligible influence on the acoustic behavior of the Helmholtz resonator. The numerical results reveal that the flow field around the orifice is dominated by the evolution of the vortex sheet and the flow pattern is influenced by the ratio of the orifice flow velocity to the grazing flow velocity. When the incident sound pressure is high or the resonance occurs, the resonator shows nonlinearity, i.e., the acoustic impedance and absorption coefficient vary not only with duct flow Mach number buy also with incident frequency and incident sound pressure level.

  4. Final Report for "Modeling Electron Cloud Diagnostics for High-Intensity Proton Accelerators"

    Energy Technology Data Exchange (ETDEWEB)

    Seth A Veitzer

    2009-09-25

    Electron clouds in accelerators such as the ILC degrade beam quality and limit operating efficiency. The need to mitigate electron clouds has a direct impact on the design and operation of these accelerators, translating into increased cost and reduced performance. Diagnostic techniques for measuring electron clouds in accelerating cavities are needed to provide an assessment of electron cloud evolution and mitigation. Accurate numerical modeling of these diagnostics is needed to validate the experimental techniques. In this Phase I, we developed detailed numerical models of microwave propagation through electron clouds in accelerating cavities with geometries relevant to existing and future high-intensity proton accelerators such as Project X and the ILC. Our numerical techniques and simulation results from the Phase I showed that there was a high probability of success in measuring both the evolution of electron clouds and the effects of non-uniform electron density distributions in Phase II.

  5. Left-Right Symmetric Models at the High-Intensity Frontier

    CERN Document Server

    Castillo-Felisola, Oscar; Helo, Juan C; Kovalenko, Sergey G; Ortiz, Sebastian E

    2015-01-01

    We study constraints on Left-Right Symmetric models from searches of semileptonic decays of $D$, $D_{s}$, $B$ mesons, mediated by heavy neutrinos $N$ with masses $m_N\\sim $ GeV that go on their mass shell leading to a resonant enhancement of the rates. Using these processes we examine, as a function of $m_N$ and $M_{W_R}$, the physics reach of the recently proposed high-intensity beam dump experiment SHiP, which is expected to produce a large sample of $D_s$ mesons. We compare these results with the corresponding reach of neutrinoless double beta decay experiments, as well as like-sign dilepton searches with displaced vertices at the LHC. We conclude that the SHiP experiment has clear advantages in probing the Left-Right Symmetric models for heavy neutrinos in the GeV mass range.

  6. High-intensity interval training in patients with coronary heart disease: Prescription models and perspectives.

    Science.gov (United States)

    Ribeiro, Paula A B; Boidin, Maxime; Juneau, Martin; Nigam, Anil; Gayda, Mathieu

    2017-01-01

    Recently, high-intensity interval training (HIIT) has emerged as an alternative and/or complementary exercise modality to continuous aerobic exercise training (CAET) in CHD patients. However, the literature contains descriptions of many HIIT protocols with different stage durations, nature of recovery and intensities. In this review, we discuss the most recent forms of validated HIIT protocols in patients with coronary heart disease (CHD) and how to prescribe and use them during short- and long-term (phase II and III) cardiac rehabilitation programs. We also compare the superior and/or equivalent short- and long-term effects of HIIT versus CAET on aerobic fitness, cardiovascular function, and quality of life; their efficiency, safety, and tolerance; and exercise adherence. Short interval HIIT was found beneficial for CHD patients with lower aerobic fitness and would ideally be used in initiation and improvement stages. Medium and/or long interval HIIT protocols may be beneficial for CHD patients with higher aerobic fitness, and would be ideally used in the improvement and maintenance stages because of their high physiological stimulus. Finally, we propose progressive individualized models of HIIT programs (phase II to III) for patients with CHD and how to ideally use them according to the clinical status of patients and phase of the cardiac rehabilitation program.

  7. Finite element modeling of heating phenomena of cracks excited by high-intensity ultrasonic pulses

    Institute of Scientific and Technical Information of China (English)

    Chen Zhao-Jiang; Zheng Jiang; Zhang Shu-Yi; Mi Xiao-Bing; Zheng Kai

    2010-01-01

    A three-dimensional thermo-mechanical coupled finite element model is built up to simulate the phenomena of dynamical contact and frictional heating of crack faces when the plate containing the crack is excited by high-intensity ultrasonic pulses. In the finite element model, the high-power ultrasonic transducer is modeled by using a piezoelectric thermal-analogy method, and the dynamical interaction between both crack faces is modeled using a contact-impact theory. In the simulations, the frictional heating taking place at the crack faces is quantitatively calculated by using finite element thermal-structural coupling analysis, especially, the influences of acoustic chaos to plate vibration and crack heating are calculated and analysed in detail Meanwhile, the related ultrasonic infrared images are also obtained experimentally, and the theoretical simulation results are in agreement with that of the experiments. The results show that, by using the theoretical method, a good simulation of dynamic interaction and friction heating process of the crack faces under non-chaotic or chaotic sound excitation can be obtained.

  8. Numerical and Physical Modeling of the Response of Resonator Liners to Intense Sound and High Speed Grazing Flow Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An innovative research program is proposed that numerically and physically models the response of resonator liners to intense sound and high speed grazing flow. The...

  9. Laser-enhanced high-intensity focused ultrasound heating in an in vivo small animal model

    Science.gov (United States)

    Jo, Janggun; Yang, Xinmai

    2016-11-01

    The enhanced heating effect during the combination of high-intensity focused ultrasound (HIFU) and low-optical-fluence laser illumination was investigated by using an in vivo murine animal model. The thighs of murine animals were synergistically irradiated by HIFU and pulsed nano-second laser light. The temperature increases in the target region were measured by a thermocouple under different HIFU pressures, which were 6.2, 7.9, and 9.8 MPa, in combination with 20 mJ/cm2 laser exposures at 532 nm wavelength. In comparison with conventional laser therapies, the laser fluence used here is at least one order of magnitude lower. The results showed that laser illumination could enhance temperature during HIFU applications. Additionally, cavitation activity was enhanced when laser and HIFU irradiation were concurrently used. Further, a theoretical simulation showed that the inertial cavitation threshold was indeed decreased when laser and HIFU irradiation were utilized concurrently.

  10. Kinetic Modeling of Next-Generation High-Energy, High-Intensity Laser-Ion Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Albright, Brian James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Yin, Lin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stark, David James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-06

    One of the long-standing problems in the community is the question of how we can model “next-generation” laser-ion acceleration in a computationally tractable way. A new particle tracking capability in the LANL VPIC kinetic plasma modeling code has enabled us to solve this long-standing problem

  11. Anomalies of Siberian High Intensity and Their Precursors in Climatic Models Output

    Science.gov (United States)

    Martynova, Yuliya; Krupchatnikov, Vladimir

    2016-04-01

    The Siberian High (SH) is a powerful pressure system that determines the weather regime during the wintertime for the huge part of Asia [Sazonov B.I., 1991]. Particularly, SH regulates an intensity and duration of frosts in Siberia. Moreover, this pressure system has a strong connection with another atmospheric centers of action of the Northern Hemisphere such as Arctic High, Icelandic Low, the Azores High [Morozova S.V., 2013]. SH variation is closely related to atmospheric dynamics processes and air temperature variations between surface and middle troposphere. The maintaining of SH mainly depends on downward through the troposphere airflow which variation is strongly affected by the Arctic oscillation (AO). Positive (negative) AO phase causes the remarkably weakening (strengthening) of the downward airflow that has strong effect on the SH behavior [Gong G. et al., 2002; Krupchatnikov V. N. et al., 2009; Martynova Yu.V. and V.N. Krupchatnikov, 2010]. SH is highly exposed to global climate change that increases standard deviation of SH intensity [Fei L.I. and G. A. O. Yong-Qi, 2015]. The changes of SH characteristics result from not only direct climate change effect (such as global temperature rise) but also feedback effect of another climate system parameters variation. Thus, these parameters can serve as precursors of the extremely SH intensity. It's important to remember that the changes of the just one component of this High-Low interaction system could affect whole system. This study is devoted to determination of the precursors of the anomaly SH behavior and estimation of changes of the determined connection in the climate change conditions. The research was provided on a base of climate system models and reanalysis data. Acknowledgements This work is partially supported by SB RAS project VIII.80.2.1, RFBR grants 14-05-00502, 16-35-00301, 16-05-00558. References Fei L.I. and G. A. O. Yong-Qi The Project Siberian High in CMIP5 Models // Atmospheric and

  12. Modelling the temperature evolution of bone under high intensity focused ultrasound.

    Science.gov (United States)

    ten Eikelder, H M M; Bošnački, D; Elevelt, A; Donato, K; Di Tullio, A; Breuer, B J T; van Wijk, J H; van Dijk, E V M; Modena, D; Yeo, S Y; Grüll, H

    2016-02-21

    Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) has been clinically shown to be effective for palliative pain management in patients suffering from skeletal metastasis. The underlying mechanism is supposed to be periosteal denervation caused by ablative temperatures reached through ultrasound heating of the cortex. The challenge is exact temperature control during sonication as MR-based thermometry approaches for bone tissue are currently not available. Thus, in contrast to the MR-HIFU ablation of soft tissue, a thermometry feedback to the HIFU is lacking, and the treatment of bone metastasis is entirely based on temperature information acquired in the soft tissue adjacent to the bone surface. However, heating of the adjacent tissue depends on the exact sonication protocol and requires extensive modelling to estimate the actual temperature of the cortex. Here we develop a computational model to calculate the spatial temperature evolution in bone and the adjacent tissue during sonication. First, a ray-tracing technique is used to compute the heat production in each spatial point serving as a source term for the second part, where the actual temperature is calculated as a function of space and time by solving the Pennes bio-heat equation. Importantly, our model includes shear waves that arise at the bone interface as well as all geometrical considerations of transducer and bone geometry. The model was compared with a theoretical approach based on the far field approximation and an MR-HIFU experiment using a bone phantom. Furthermore, we investigated the contribution of shear waves to the heat production and resulting temperatures in bone. The temperature evolution predicted by our model was in accordance with the far field approximation and agreed well with the experimental data obtained in phantoms. Our model allows the simulation of the HIFU treatments of bone metastasis in patients and can be extended to a planning tool prior to MR

  13. Modelling the temperature evolution of bone under high intensity focused ultrasound

    Science.gov (United States)

    ten Eikelder, H. M. M.; Bošnački, D.; Elevelt, A.; Donato, K.; Di Tullio, A.; Breuer, B. J. T.; van Wijk, J. H.; van Dijk, E. V. M.; Modena, D.; Yeo, S. Y.; Grüll, H.

    2016-02-01

    Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) has been clinically shown to be effective for palliative pain management in patients suffering from skeletal metastasis. The underlying mechanism is supposed to be periosteal denervation caused by ablative temperatures reached through ultrasound heating of the cortex. The challenge is exact temperature control during sonication as MR-based thermometry approaches for bone tissue are currently not available. Thus, in contrast to the MR-HIFU ablation of soft tissue, a thermometry feedback to the HIFU is lacking, and the treatment of bone metastasis is entirely based on temperature information acquired in the soft tissue adjacent to the bone surface. However, heating of the adjacent tissue depends on the exact sonication protocol and requires extensive modelling to estimate the actual temperature of the cortex. Here we develop a computational model to calculate the spatial temperature evolution in bone and the adjacent tissue during sonication. First, a ray-tracing technique is used to compute the heat production in each spatial point serving as a source term for the second part, where the actual temperature is calculated as a function of space and time by solving the Pennes bio-heat equation. Importantly, our model includes shear waves that arise at the bone interface as well as all geometrical considerations of transducer and bone geometry. The model was compared with a theoretical approach based on the far field approximation and an MR-HIFU experiment using a bone phantom. Furthermore, we investigated the contribution of shear waves to the heat production and resulting temperatures in bone. The temperature evolution predicted by our model was in accordance with the far field approximation and agreed well with the experimental data obtained in phantoms. Our model allows the simulation of the HIFU treatments of bone metastasis in patients and can be extended to a planning tool prior to MR

  14. A High School Intensive Summer Mandarin Course: Program Model and Learner Outcomes

    Science.gov (United States)

    Xu, Xiaoqiu; Padilla, Amado M.; Silva, Duarte; Masuda, Norman

    2012-01-01

    This article describes a STARTALK intensive summer high school Mandarin language and culture program that was conducted for three summers. Participants across the three years included 40 Mandarin Level II and 53 Mandarin Level III high school students. Quantitative and qualitative data are presented to show the effectiveness of the program.…

  15. Modeling and Predicting Tissue Movement and Deformation for High Intensity Focused Ultrasound Therapy

    Science.gov (United States)

    Liao, Xiangyun; Yuan, Zhiyong; Lai, Qianfeng; Guo, Jiaxiang; Zheng, Qi; Yu, Sijiao; Tong, Qianqian; Si, Weixin; Sun, Mingui

    2015-01-01

    Purpose In ultrasound-guided High Intensity Focused Ultrasound (HIFU) therapy, the target tissue (such as a tumor) often moves and/or deforms in response to an external force. This problem creates difficulties in treating patients and can lead to the destruction of normal tissue. In order to solve this problem, we present a novel method to model and predict the movement and deformation of the target tissue during ultrasound-guided HIFU therapy. Methods Our method computationally predicts the position of the target tissue under external force. This prediction allows appropriate adjustments in the focal region during the application of HIFU so that the treatment head is kept aligned with the diseased tissue through the course of therapy. To accomplish this goal, we utilize the cow tissue as the experimental target tissue to collect spatial sequences of ultrasound images using the HIFU equipment. A Geodesic Localized Chan-Vese (GLCV) model is developed to segment the target tissue images. A 3D target tissue model is built based on the segmented results. A versatile particle framework is constructed based on Smoothed Particle Hydrodynamics (SPH) to model the movement and deformation of the target tissue. Further, an iterative parameter estimation algorithm is utilized to determine the essential parameters of the versatile particle framework. Finally, the versatile particle framework with the determined parameters is used to estimate the movement and deformation of the target tissue. Results To validate our method, we compare the predicted contours with the ground truth contours. We found that the lowest, highest and average Dice Similarity Coefficient (DSC) values between predicted and ground truth contours were, respectively, 0.9615, 0.9770 and 0.9697. Conclusion Our experimental result indicates that the proposed method can effectively predict the dynamic contours of the moving and deforming tissue during ultrasound-guided HIFU therapy. PMID:25993644

  16. Modeling of high-intensity focused ultrasound-induced lesions in the presence of cavitation bubbles

    Science.gov (United States)

    Chavrier; Chapelon; Gelet; Cathignol

    2000-07-01

    The classical "Bio Heat Transfer Equation (BHTE)" model is adapted to take into account the effects of oscillating microbubbles that occur naturally in the tissue during high-intensity focused ultrasound (HIFU) treatment. First, the Gilmore-Akulichev model is used to quantify the acoustic pressure scattered by microbubbles submitted to HIFU. Because this scattered pressure is not monochromatic, the concept of harmonic attenuation is introduced and a global attenuation coefficient is estimated for bubble-filled tissues. The first results show that this global attenuation coefficient varies significantly with respect to several parameters such as the frequency and the density of microbubbles in the medium, but also with respect to the incident acoustic pressure which thus becomes a transcendental function. Under these conditions, a layer-by-layer modeling, in the direction of propagation, is proposed to calculate the ultrasonic beam. Finally, the BHTE is solved and the HIFU-induced lesions are estimated by the calculation of the thermal dose. Using this model, it can be observed first that, when the firing power increases, the lesion develops clearly in the direction of the transducer, with a shape agreeing with in vivo experimentation. Next, it is observed that the lesion can be significantly modified in size and position, if an interface (skin or inner wall) is simulated as a zone with multiple cavitation nuclei. With a firing power increase, it is also shown how a secondary lesion can appear at the interface and how, beyond a certain threshold, this lesion develops at the main lesion expense. Finally, a better in-depth homogeneity of lesions is observed when the acoustic frequency of HIFU is increased.

  17. Comparing Particle-in-Cell QED Models for High-Intensity Laser-Plasma Interactions

    Science.gov (United States)

    Luedtke, Scott V.; Labun, Lance A.; Hegelich, Björn Manuel

    2016-10-01

    High-intensity lasers, such as the Texas Petawatt, are pushing into new regimes of laser-matter interaction, requiring continuing improvement and inclusion of new physics effects in computer simulations. Experiments at the Texas Petawatt are reaching intensity regimes where new physics-quantum electrodynamics (QED) corrections to otherwise classical plasma dynamics-becomes important. We have two particle-in-cell (PIC) codes with different QED implementations. We review the theory of photon emission in QED-strong fields, and cover the differing PIC implementations. We show predictions from the two codes and compare with ongoing experiments. This work was supported by NNSA cooperative agreement DE-NA0002008, the Defense Advanced Research Projects Agency's PULSE program (12-63-PULSE-FP014) and the Air Force Office of Scientific Research (FA9550-14-1-0045). HPC resources provided by TACC.

  18. Novel use of noninvasive high-intensity focused ultrasonography for intercostal nerve neurolysis in a swine model.

    Science.gov (United States)

    Gulati, Amitabh; Loh, Jeffrey; Gutta, Narendra B; Ezell, Paula C; Monette, Sébastien; Erinjeri, Joseph P; Maybody, Majid; Solomon, Stephen

    2014-01-01

    High-intensity focused ultrasound (HIFU) is a noninvasive thermal ablation technique. High-intensity focused ultrasound has been used in small-animal models to lesion neural tissue selectively. This study aimed to evaluate the efficacy of HIFU in a large-animal model for ablation of nerves similar in size to human nerves. Twelve acute magnetic resonance-guided HIFU ablation lesions were created in intercostal nerves in a swine model. In a second pig, as a control, 4 radiofrequency ablation and 4 alcohol lesions were performed on intercostal nerves under ultrasound guidance. Preprocedural and postprocedural magnetic resonance imaging was then performed to evaluate radiologically the lesion size created by HIFU. Animals were euthanized 1 hour postprocedure, and necropsy was performed to collect tissue samples for histopathologic analysis. On gross and histological examination of the intercostal nerve, acute HIFU nerve lesions showed evidence of well-demarcated, acute, focally extensive thermal necrosis. Four intercostal nerves ablated with HIFU were sent for histopathologic analysis, with 2 of 4 lesions showing pathologic damage to the intercostal nerve. Similar results were shown with radiofrequency ablation technique, whereas the intercostal nerves appeared histologically intact with alcohol ablation. High-intensity focused ultrasound may be used as a noninvasive neurolytic technique in swine. High-intensity focused ultrasound may have potential as a neuroablation technique for patients with chronic and cancer pain.

  19. Intensive case management for high-risk patients with first-episode psychosis: service model and outcomes.

    Science.gov (United States)

    Brewer, Warrick J; Lambert, Timothy J; Witt, Katrina; Dileo, John; Duff, Cameron; Crlenjak, Carol; McGorry, Patrick D; Murphy, Brendan P

    2015-01-01

    The first episode of psychosis is a crucial period when early intervention can alter the trajectory of the young person's ongoing mental health and general functioning. After an investigation into completed suicides in the Early Psychosis Prevention and Intervention Centre (EPPIC) programme, the intensive case management subprogramme was developed in 2003 to provide assertive outreach to young people having a first episode of psychosis who are at high risk owing to risk to self or others, disengagement, or suboptimal recovery. We report intensive case management model development, characterise the target cohort, and report on outcomes compared with EPPIC treatment as usual. Inclusion criteria, staff support, referral pathways, clinical review processes, models of engagement and care, and risk management protocols are described. We compared 120 consecutive referrals with 50 EPPIC treatment as usual patients (age 15-24 years) in a naturalistic stratified quasi-experimental real-world design. Key performance indicators of service use plus engagement and suicide attempts were compared between EPPIC treatment as usual and intensive case management, and psychosocial and clinical measures were compared between intensive case management referral and discharge. Referrals were predominately unemployed males with low levels of functioning and educational attainment. They were characterised by a family history of mental illness, migration and early separation, with substantial trauma, history of violence, and forensic attention. Intensive case management improved psychopathology and psychosocial outcomes in high-risk patients and reduced risk ratings, admissions, bed days, and crisis contacts. Characterisation of intensive case management patients validated the clinical research focus and identified a first episode of psychosis high-risk subgroup. In a real-world study, implementation of an intensive case management stream within a well-established first episode of psychosis

  20. High-intensity ultrasound production of Maillard reaction flavor compounds in a cysteine-xylose model system.

    Science.gov (United States)

    Ong, Olivia X H; Seow, Yi-Xin; Ong, Peter K C; Zhou, Weibiao

    2015-09-01

    Application of high intensity ultrasound has shown potential in the production of Maillard reaction odor-active flavor compounds in model systems. The impact of initial pH, sonication duration, and ultrasound intensity on the production of Maillard reaction products (MRPs) by ultrasound processing in a cysteine-xylose model system were evaluated using Response Surface Methodology (RSM) with a modified mathematical model. Generation of selected MRPs, 2-methylthiophene and tetramethyl pyrazine, was optimal at an initial pH of 6.00, accompanied with 78.1 min of processing at an ultrasound intensity of 19.8 W cm(-2). However, identification of volatiles using gas chromatography-mass spectrometry (GC/MS) revealed that ultrasound-assisted Maillard reactions generated fewer sulfur-containing volatile flavor compounds as compared to conventional heat treatment of the model system. Likely reasons for this difference in flavor profile include the expulsion of H2S due to ultrasonic degassing and inefficient transmission of ultrasonic energy. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Models are likely to underestimate increase in heavy rainfall in the extratropical regions with high rainfall intensity

    Science.gov (United States)

    Borodina, Aleksandra; Fischer, Erich M.; Knutti, Reto

    2017-07-01

    Model projections of regional changes in heavy rainfall are uncertain. On timescales of few decades, internal variability plays an important role and therefore poses a challenge to detect robust model response in heavy rainfall to rising temperatures. We use spatial aggregation to reduce the major role of internal variability and evaluate the heavy rainfall response to warming temperatures with observations. We show that in the regions with high rainfall intensity and for which gridded observations exist, most of the models underestimate the historical scaling of heavy rainfall and the land fraction with significant positive heavy rainfall scalings during the historical period. The historical behavior is correlated with the projected heavy rainfall intensification across models allowing to apply an observational constraint, i.e., to calibrate multimodel ensembles with observations in order to narrow the range of projections. The constraint suggests a substantially stronger intensification of future heavy rainfall than the multimodel mean.

  2. Intensity and Development Forecasts of Tropical Cyclones by the JMA High-Resolution Global NWP Model: Impacts of Resolution Enhancement

    Science.gov (United States)

    Komori, T.; Kitagawa, H.

    2007-12-01

    It is widely considered that a spatial resolution of numerical weather prediction (NWP) model plays an important role for forecasting severe weather events such as tropical cyclones (TCs) and heavy rainfall. Under the KAKUSHIN project (funded by the Japanese Ministry of Education, Culture, Sports, Science and Technology), the Japan Meteorological Agency (JMA) has developed a new Global Spectral Model (GSM) with a high horizontal resolution of about 20km and 60 vertical layers (hereafter called g20km GSMh), which is utilized to evaluate severe weather events in future climate. The 20km GSM will be operational in November 2007 replacing the current GSM with a horizontal resolution of about 60km and 40 vertical layers (hereafter called g60km GSMh). In the present study, we investigate how a model resolution impacts on TC forecasts because this resolution enhancement aims to improve the model's ability to forecast severe weather. Due to the more realistic model topography in higher horizontal resolution, the 20km GSM can give more accurate forecasts of orographic precipitation than the 60km GSM, especially over the area range of heavy precipitation. According to the statistically verified results, the enhancement of horizontal and vertical resolution appears to fairly improve the accuracy of TC intensity forecasts. However, for TC track forecasts, it may be more important to accurately represent large-scale environmental contexts surrounding the TC than to resolve the TC structure itself. In order to clarify resolution impacts on the TC intensity prediction, we categorize the TC intensity forecasts into three stages (development stage, maturation stage and dissipation stage). The results show that the effectiveness of the resolution enhancement is bigger in the development stage and relatively small in the maturation and dissipation stages. For the maturation and dissipation stages, improvement of physical processes seems to be more important than the resolution

  3. A Low Mortality, High Morbidity Reduced Intensity Status Epilepticus (RISE) Model of Epilepsy and Epileptogenesis in the Rat

    Science.gov (United States)

    Pérès, Isabelle A. A.; Hadid, Rebecca D.; Amada, Naoki; Hill, Charlotte; Williams, Claire; Stanford, Ian M.; Morris, Christopher M.; Jones, Roland S. G.; Whalley, Benjamin J.; Woodhall, Gavin L.

    2016-01-01

    Animal models of acquired epilepsies aim to provide researchers with tools for use in understanding the processes underlying the acquisition, development and establishment of the disorder. Typically, following a systemic or local insult, vulnerable brain regions undergo a process leading to the development, over time, of spontaneous recurrent seizures. Many such models make use of a period of intense seizure activity or status epilepticus, and this may be associated with high mortality and/or global damage to large areas of the brain. These undesirable elements have driven improvements in the design of chronic epilepsy models, for example the lithium-pilocarpine epileptogenesis model. Here, we present an optimised model of chronic epilepsy that reduces mortality to 1% whilst retaining features of high epileptogenicity and development of spontaneous seizures. Using local field potential recordings from hippocampus in vitro as a probe, we show that the model does not result in significant loss of neuronal network function in area CA3 and, instead, subtle alterations in network dynamics appear during a process of epileptogenesis, which eventually leads to a chronic seizure state. The model’s features of very low mortality and high morbidity in the absence of global neuronal damage offer the chance to explore the processes underlying epileptogenesis in detail, in a population of animals not defined by their resistance to seizures, whilst acknowledging and being driven by the 3Rs (Replacement, Refinement and Reduction of animal use in scientific procedures) principles. PMID:26909803

  4. Therapeutic Effects of Microbubbles Added to Combined High-Intensity Focused Ultrasound and Chemotherapy in a Pancreatic Cancer Xenograft Model

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Mi Hye [Department of Radiology, Konkuk University Medical Center, Seoul 05030 (Korea, Republic of); Lee, Jae Young [Department of Radiology, Seoul National University Hospital, Seoul 03080 (Korea, Republic of); Kim, Hae Ri [Department of Pre-Dentistry, Gangneung-Wonju National University College of Dentistry, Gangneung 25457 (Korea, Republic of); Kim, Bo Ram; Park, Eun-Joo; Kim, Hoe Suk; Han, Joon Koo [Department of Radiology, Seoul National University Hospital, Seoul 03080 (Korea, Republic of); Choi, Byung Ihn [Department of Radiology, Chung-Ang University Hospital, Seoul 06973 (Korea, Republic of)

    2016-11-01

    To investigate whether high-intensity focused ultrasound (HIFU) combined with microbubbles enhances the therapeutic effects of chemotherapy. A pancreatic cancer xenograft model was established using BALB/c nude mice and luciferase-expressing human pancreatic cancer cells. Mice were randomly assigned to five groups according to treatment: control (n = 10), gemcitabine alone (GEM; n = 12), HIFU with microbubbles (HIFU + MB, n = 11), combined HIFU and gemcitabine (HIGEM; n = 12), and HIGEM + MB (n = 13). After three weekly treatments, apoptosis rates were evaluated using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay in two mice per group. Tumor volume and bioluminescence were monitored using high-resolution 3D ultrasound imaging and in vivo bioluminescence imaging for eight weeks in the remaining mice. The HIGEM + MB group showed significantly higher apoptosis rates than the other groups (p < 0.05) and exhibited the slowest tumor growth. From week 5, the tumor-volume-ratio relative to the baseline tumor volume was significantly lower in the HIGEM + MB group than in the control, GEM, and HIFU + MB groups (p < 0.05). Despite visible distinction, the HIGEM and HIGEM + MB groups showed no significant differences. High-intensity focused ultrasound combined with microbubbles enhances the therapeutic effects of gemcitabine chemotherapy in a pancreatic cancer xenograft model.

  5. Therapeutic effects of microbubble added to combined high-intensity focused ultrasound and chemotherapy in a pancreatic cancer xenograft model

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Mi Hye [Dept. of Radiology, Konkuk University Medical Center, Seoul (Korea, Republic of); Lee, Jae Young; Kim, Bo Ram; Park, Eun Joo; Kim, Hoe Suk; Han, Joon Koo [Dept. of Radiology, Seoul National University Hospital, Seoul (Korea, Republic of); Kim, Hae Ri [Dept. of Pre-Dentistry, Gangneung-Wonju National University College of Dentistry, Gangneung (Korea, Republic of); Choi, Byung Ihn [Dept. of Radiology, Chung-Ang University Hospital, Seoul (Korea, Republic of)

    2016-09-15

    To investigate whether high-intensity focused ultrasound (HIFU) combined with microbubbles enhances the therapeutic effects of chemotherapy. A pancreatic cancer xenograft model was established using BALB/c nude mice and luciferase-expressing human pancreatic cancer cells. Mice were randomly assigned to five groups according to treatment: control (n = 10), gemcitabine alone (GEM; n = 12), HIFU with microbubbles (HIFU + MB, n = 11), combined HIFU and gemcitabine (HIGEM; n = 12), and HIGEM + MB (n = 13). After three weekly treatments, apoptosis rates were evaluated using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay in two mice per group. Tumor volume and bioluminescence were monitored using high-resolution 3D ultrasound imaging and in vivo bioluminescence imaging for eight weeks in the remaining mice. The HIGEM + MB group showed significantly higher apoptosis rates than the other groups (p < 0.05) and exhibited the slowest tumor growth. From week 5, the tumor-volume-ratio relative to the baseline tumor volume was significantly lower in the HIGEM + MB group than in the control, GEM, and HIFU + MB groups (p < 0.05). Despite visible distinction, the HIGEM and HIGEM + MB groups showed no significant differences. High-intensity focused ultrasound combined with microbubbles enhances the therapeutic effects of gemcitabine chemotherapy in a pancreatic cancer xenograft model.

  6. Modelling single shot damage thresholds of multilayer optics for high-intensity short-wavelength radiation sources.

    Science.gov (United States)

    Loch, R A; Sobierajski, R; Louis, E; Bosgra, J; Bijkerk, F

    2012-12-17

    The single shot damage thresholds of multilayer optics for high-intensity short-wavelength radiation sources are theoretically investigated, using a model developed on the basis of experimental data obtained at the FLASH and LCLS free electron lasers. We compare the radiation hardness of commonly used multilayer optics and propose new material combinations selected for a high damage threshold. Our study demonstrates that the damage thresholds of multilayer optics can vary over a large range of incidence fluences and can be as high as several hundreds of mJ/cm(2). This strongly suggests that multilayer mirrors are serious candidates for damage resistant optics. Especially, multilayer optics based on Li(2)O spacers are very promising for use in current and future short-wavelength radiation sources.

  7. Effect of cathode model on arc attachment for short high-intensity arc on a refractory cathode

    Science.gov (United States)

    Javidi Shirvan, Alireza; Choquet, Isabelle; Nilsson, Håkan

    2016-12-01

    Various models coupling the refractory cathode, the cathode sheath and the arc at atmospheric pressure exist. They assume a homogeneous cathode with a uniform physical state, and differ by the cathode layer and the plasma arc model. However even the most advanced of these models still fail in predicting the extent of the arc attachment when applied to short high-intensity arcs such as gas tungsten arcs. Cathodes operating in these conditions present a non-uniform physical state. A model taking into account the first level of this non-homogeneity is proposed based on physical criteria. Calculations are done for 5 mm argon arcs with a thoriated tungsten cathode. The results obtained show that radiative heating and cooling of the cathode surface are of the same order. They also show that cathode inhomogeneity has a significant effect on the arc attachment, the arc temperature and pressure. When changing the arc current (100 A, 200 A) the proposed model allows predicting trends observed experimentally that cannot be captured by the homogeneous cathode model unless restricting a priori the size of the arc attachment. The cathode physics is thus an important element to include to obtain a comprehensive and predictive arc model.

  8. Effect of high intensity ultrasound on the fermentation profile of Lactobacillus sakei in a meat model system.

    Science.gov (United States)

    Ojha, Kumari Shikha; Kerry, Joseph P; Alvarez, Carlos; Walsh, Des; Tiwari, Brijesh K

    2016-07-01

    The objective of this study was to investigate the efficacy of high intensity ultrasound on the fermentation profile of Lactobacillus sakei in a meat model system. Ultrasound power level (0-68.5 W) and sonication time (0-9 min) at 20 °C were assessed against the growth of L. sakei using a Microplate reader over a period of 24h. The L. sakei growth data showed a good fit with the Gompertz model (R(2)>0.90; SEfermentation of ultrasound treated samples showed antimicrobial activity against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Salmonella typhimurium at lower concentrations compared to control. No significant difference (pfermentation period. This study showed that both stimulation and retardation of L. sakei is possible, depending on the ultrasonic power and sonication time employed. Hence, fermentation process involving probiotics to develop functional food products can be tailored by selection of ultrasound processing parameters.

  9. Full Modelling of High-Intensity Focused Ultrasound and Thermal Heating in the Kidney using Realistic Patient Models.

    Science.gov (United States)

    Suomi, Visa; Jaros, Jiri; Treeby, Bradley; Cleveland, Robin

    2017-07-28

    High-intensity focused ultrasound (HIFU) therapy can be used for non-invasive treatment of kidney (renal) cancer, but the clinical outcomes have been variable. In this study, the efficacy of renal HIFU therapy was studied using nonlinear acoustic and thermal simulations in three patients. The acoustic simulations were conducted with and without refraction in order to investigate its effect on the shape, size and pressure distribution at the focus. The values for the attenuation, sound speed, perfusion and thermal conductivity of the kidney were varied over the reported ranges to determine the effect of variability on heating. Furthermore, the phase aberration was studied in order to quantify the underlying phase shifts using a second order polynomial function. The ultrasound field intensity was found to drop on average 11.1 dB with refraction and 6.4 dB without refraction. Reflection at tissue interfaces was found to result in a loss less than 0.1 dB. Focal point splitting due to refraction significantly reduced the heating efficacy. Of all the tissue parameters, perfusion was found to affect the heating the most. Small changes in temperature were seen with varying attenuation and thermal conductivity, but no visible changes were present with sound speed variations. The aberration study revealed an underlying trend in the spatial distribution of the phase shifts. The results show that the efficacy of HIFU therapy in the kidney could be improved with aberration correction. A method is proposed by which patient specific pre-treatment calculations could be used to overcome the aberration and therefore make ultrasound treatment possible.

  10. Beam-commissioning study of high-intensity accelerators using virtual accelerator model

    Science.gov (United States)

    Harada, H.; Shigaki, K.; Irie, Y.; Noda, F.; Hotchi, H.; Saha, P. K.; Shobuda, Y.; Sako, H.; Furukawa, K.; Machida, S.

    2009-04-01

    In order to control large-scale accelerators efficiently, a control system with a virtual accelerator model was constructed. The virtual accelerator (VA) is an on-line beam simulator provided with a beam monitor scheme. The VA is based upon the Experimental Physics and Industrial Control System (EPICS) and is configured under the EPICS input/output controller (IOC) in parallel with a real accelerator (RA). Thus, the machine operator can access the parameters of the RA through the channel access client and then feed them to the VA, and vice versa. Such a control scheme facilitates developments of the commissioning tools, feasibility study of the proposed accelerator parameters and examination of the measured accelerator data. This paper describes the beam commissioning results and activities by using the VA at the J-PARC 3-GeV rapid-cycling synchrotron (RCS).

  11. Beam-commissioning study of high-intensity accelerators using virtual accelerator model

    Energy Technology Data Exchange (ETDEWEB)

    Harada, H. [Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima-shi, Hiroshima 739-8526 (Japan)], E-mail: harada@hepl.hiroshima-u.ac.jp; Shigaki, K. [Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima-shi, Hiroshima 739-8526 (Japan); Irie, Y. [Accelerator Laboratory, High Energy Accelerator Research Organization (KEK), Tsukuba-shi, Ibaraki 305-0801 (Japan); Noda, F. [Energy and Environmental Systems Laboratory, Hitachi, Ltd, 7-2-1 Omika-cho, Hitachi-shi, Ibaraki 319-1221 (Japan); Hotchi, H.; Saha, P.K.; Shobuda, Y.; Sako, H. [Japan Proton Accelerator Research Complex, 2-4 Shirane Shirakata, Tokai-mura, Naka-gun, Ibaraki 319-1195 (Japan); Furukawa, K. [Accelerator Laboratory, High Energy Accelerator Research Organization (KEK), Tsukuba-shi, Ibaraki 305-0801 (Japan); Machida, S. [Science and Technology Facilities Council, Rutherford Appleton Laboratory, Chilton, Didcot, Oxon OX11, 0QX (United Kingdom)

    2009-04-21

    In order to control large-scale accelerators efficiently, a control system with a virtual accelerator model was constructed. The virtual accelerator (VA) is an on-line beam simulator provided with a beam monitor scheme. The VA is based upon the Experimental Physics and Industrial Control System (EPICS) and is configured under the EPICS input/output controller (IOC) in parallel with a real accelerator (RA). Thus, the machine operator can access the parameters of the RA through the channel access client and then feed them to the VA, and vice versa. Such a control scheme facilitates developments of the commissioning tools, feasibility study of the proposed accelerator parameters and examination of the measured accelerator data. This paper describes the beam commissioning results and activities by using the VA at the J-PARC 3-GeV rapid-cycling synchrotron (RCS)

  12. High-intensity interval and endurance training are associated with divergent skeletal muscle adaptations in a rodent model of hypertension.

    Science.gov (United States)

    Holloway, Tanya M; Bloemberg, Darin; da Silva, Mayne L; Quadrilatero, Joe; Spriet, Lawrence L

    2015-06-01

    Skeletal muscle is extremely adaptable to a variety of metabolic challenges, as both traditional moderate-intensity endurance (ET) and high-intensity interval training (HIIT) increases oxidative potential in a coordinated manner. Although these responses have been clearly demonstrated in healthy individuals, it remains to be determined whether both produce similar responses in the context of hypertension, one of the most prevalent and costly diseases worldwide. Therefore, in the current study, we used the Dahl sodium-sensitive rat, a model of hypertension, to determine the molecular responses to 4 wk of either ET or HIIT in the red (RG) and white gastrocnemius (WG) muscles. In the RG, both ET and HIIT increased the content of electron transport chain proteins and increased succinate dehydrogenase (SDH) content in type I fibers. Although both intensities of exercise shifted fiber type in RG (increased IIA, decreased IIX), only HIIT was associated with a reduction in endothelial nitric oxide synthase and an increase in HIF-1α proteins. In the WG, both ET and HIIT increased markers of the electron transport chain; however, HIIT decreased SDH content in a fiber-specific manner. ET increased type IIA, decreased IIB fibers, and increased capillarization, while, in contrast, HIIT increased the percentage of IIB fibers, decreased capillary-to-fiber ratios, decreased endothelial nitric oxide synthase, and increased hypoxia inducible factor-1α (HIF-1α) protein. Altogether, these data show that unlike in healthy animals, ET and HIIT have divergent effects in the skeletal muscle of hypertensive rats. This suggests ET may be optimal at improving the oxidative capacity of skeletal muscle in animals with hypertension.

  13. LHC Report: reaching high intensity

    CERN Multimedia

    Jan Uythoven

    2015-01-01

    After both beams having been ramped to their full energy of 6.5 TeV, the last two weeks saw the beam commissioning process advancing on many fronts. An important milestone was achieved when operators succeeded in circulating a nominal-intensity bunch. During the operation, some sudden beam losses resulted in beam dumps at top energy, a problem that needed to be understood and resolved.   In 2015 the LHC will be circulating around 2800 bunches in each beam and each bunch will contain just over 1 x 1011 protons. Until a few days ago commissioning was taking place with single bunches of 5 x 109 protons. The first nominal bunch with an intensity of 1 x 1011 protons was injected on Tuesday, 21 April. In order to circulate such a high-intensity bunch safely, the whole protection system must be working correctly: collimators, which protect the aperture, are set at preliminary values known as coarse settings; all kicker magnets for injecting and extracting the beams are commissioned with beam an...

  14. Stimulated Raman backscattering at high laser intensities

    Energy Technology Data Exchange (ETDEWEB)

    Skoric, M.M. [Vinca Inst. of Nuclear Sciences, Belgrade (Yugoslavia); Tajima, Toshiki; Sasaki, Akira; Maluckov, A.; Jovanovic, M.

    1998-03-01

    Signatures of Stimulated Raman backscattering of a short-pulse high-intensity laser interacting with an underdense plasma are discussed. We introduce a nonlinear three-wave interaction model that accounts for laser pump depletion and relativistic detuning. A mechanism is revealed based on a generic route to chaos, that predicts a progressive increase of the backscatter complexity with a growing laser intensity. Importance of kinetic effects is outlined and demonstrated in fluid-hybrid and particle simulations. As an application, we show that spectral anomalies of the backscatter, predicted by the above model, are consistent with recent sub-picosecond, high-intensity laser gas-target measurements at Livermore and elsewhere. Finally, a recently proposed scheme for generation of ultra-short, low-prepulse laser pulses by Raman backscattering in a thin foil target, is shown. (author)

  15. High intensity protons in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Montag, C.; Ahrens, L.; Blaskiewicz, M.; Brennan, J. M.; Drees, K. A.; Fischer, W.; Huang, H.; Minty, M.; Robert-Demolaize, G.; Thieberger, P.; Yip, K.

    2012-01-05

    During the 2012 summer shutdown a pair of electron lenses will be installed in RHIC, allowing the beam-beam parameter to be increased by roughly 50 percent. To realize the corresponding luminosity increase bunch intensities have to be increased by 50 percent, to 2.5 {center_dot} 10{sup 11} protons per bunch. We list the various RHIC subsystems that are most affected by this increase, and propose beam studies to ensure their readiness. The proton luminosity in RHIC is presently limited by the beam-beam effect. To overcome this limitation, electron lenses will be installed in IR10. With the help of these devices, the headon beam-beam kick experienced during proton-proton collisions will be partially compensated, allowing for a larger beam-beam tuneshift at these collision points, and therefore increasing the luminosity. This will be accomplished by increasing the proton bunch intensity from the presently achieved 1.65 {center_dot} 10{sup 11} protons per bunch in 109 bunches per beam to 2.5 {center_dot} 10{sup 11}, thus roughly doubling the luminosity. In a further upgrade we aim for bunch intensities up to 3 {center_dot} 10{sup 11} protons per bunch. With RHIC originally being designed for a bunch intensity of 1 {center_dot} 10{sup 11} protons per bunch in 56 bunches, this six-fold increase in the total beam intensity by far exceeds the design parameters of the machine, and therefore potentially of its subsystems. In this note, we present a list of major subsystems that are of potential concern regarding this intensity upgrade, show their demonstrated performance at present intensities, and propose measures and beam experiments to study their readiness for the projected future intensities.

  16. Displacement analysis of diagnostic ultrasound backscatter: A methodology for characterizing, modeling, and monitoring high intensity focused ultrasound therapy

    OpenAIRE

    2010-01-01

    Accurate monitoring of high intensity focused ultrasound (HIFU) therapy is critical for widespread clinical use. Pulse-echo diagnostic ultrasound (DU) is known to exhibit temperature sensitivity through relative changes in time-of-flight between two sets of radio frequency (RF) backscatter measurements, one acquired before and one after therapy. These relative displacements, combined with knowledge of the exposure protocol, material properties, heat transfer, and measurement noise statistics,...

  17. Large, high-intensity fire events in Southern California shrublands: Debunking the fine-grain age patch model

    Science.gov (United States)

    Keeley, J.E.; Zedler, P.H.

    2009-01-01

    We evaluate the fine-grain age patch model of fire regimes in southern California shrublands. Proponents contend that the historical condition was characterized by frequent small to moderate size, slow-moving smoldering fires, and that this regime has been disrupted by fire suppression activities that have caused unnatural fuel accumulation and anomalously large and catastrophic wildfires. A review of more than 100 19th-century newspaper reports reveals that large, high-intensity wildfires predate modern fire suppression policy, and extensive newspaper coverage plus first-hand accounts support the conclusion that the 1889 Santiago Canyon Fire was the largest fire in California history. Proponents of the fine-grain age patch model contend that even the very earliest 20th-century fires were the result of fire suppression disrupting natural fuel structure. We tested that hypothesis and found that, within the fire perimeters of two of the largest early fire events in 1919 and 1932, prior fire suppression activities were insufficient to have altered the natural fuel structure. Over the last 130 years there has been no significant change in the incidence of large fires greater than 10000 ha, consistent with the conclusion that fire suppression activities are not the cause of these fire events. Eight megafires (???50 000 ha) are recorded for the region, and half have occurred in the last five years. These burned through a mosaic of age classes, which raises doubts that accumulation of old age classes explains these events. Extreme drought is a plausible explanation for this recent rash of such events, and it is hypothesized that these are due to droughts that led to increased dead fine fuels that promoted the incidence of firebrands and spot fires. A major shortcoming of the fine-grain age patch model is that it requires age-dependent flammability of shrubland fuels, but seral stage chaparral is dominated by short-lived species that create a dense surface layer of fine

  18. Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of Duchenne muscular dystrophy.

    Directory of Open Access Journals (Sweden)

    Susan A Novotny

    Full Text Available The objective of the study was to determine if low intensity, high frequency vibration training impacted the musculoskeletal system in a mouse model of Duchenne muscular dystrophy, relative to healthy mice. Three-week old wildtype (n = 26 and mdx mice (n = 22 were randomized to non-vibrated or vibrated (45 Hz and 0.6 g, 15 min/d, 5 d/wk groups. In vivo and ex vivo contractile function of the anterior crural and extensor digitorum longus muscles, respectively, were assessed following 8 wks of vibration. Mdx mice were injected 5 and 1 days prior to sacrifice with Calcein and Xylenol, respectively. Muscles were prepared for histological and triglyceride analyses and subcutaneous and visceral fat pads were excised and weighed. Tibial bones were dissected and analyzed by micro-computed tomography for trabecular morphometry at the metaphysis, and cortical geometry and density at the mid-diaphysis. Three-point bending tests were used to assess cortical bone mechanical properties and a subset of tibiae was processed for dynamic histomorphometry. Vibration training for 8 wks did not alter trabecular morphometry, dynamic histomorphometry, cortical geometry, or mechanical properties (P ≥ 0.34. Vibration did not alter any measure of muscle contractile function (P ≥ 0.12; however the preservation of muscle function and morphology in mdx mice indicates vibration is not deleterious to muscle lacking dystrophin. Vibrated mice had smaller subcutaneous fat pads (P = 0.03 and higher intramuscular triglyceride concentrations (P = 0.03. These data suggest that vibration training at 45 Hz and 0.6 g did not significantly impact the tibial bone and the surrounding musculature, but may influence fat distribution in mice.

  19. Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of Duchenne muscular dystrophy.

    Science.gov (United States)

    Novotny, Susan A; Mader, Tara L; Greising, Angela G; Lin, Angela S; Guldberg, Robert E; Warren, Gordon L; Lowe, Dawn A

    2014-01-01

    The objective of the study was to determine if low intensity, high frequency vibration training impacted the musculoskeletal system in a mouse model of Duchenne muscular dystrophy, relative to healthy mice. Three-week old wildtype (n = 26) and mdx mice (n = 22) were randomized to non-vibrated or vibrated (45 Hz and 0.6 g, 15 min/d, 5 d/wk) groups. In vivo and ex vivo contractile function of the anterior crural and extensor digitorum longus muscles, respectively, were assessed following 8 wks of vibration. Mdx mice were injected 5 and 1 days prior to sacrifice with Calcein and Xylenol, respectively. Muscles were prepared for histological and triglyceride analyses and subcutaneous and visceral fat pads were excised and weighed. Tibial bones were dissected and analyzed by micro-computed tomography for trabecular morphometry at the metaphysis, and cortical geometry and density at the mid-diaphysis. Three-point bending tests were used to assess cortical bone mechanical properties and a subset of tibiae was processed for dynamic histomorphometry. Vibration training for 8 wks did not alter trabecular morphometry, dynamic histomorphometry, cortical geometry, or mechanical properties (P ≥ 0.34). Vibration did not alter any measure of muscle contractile function (P ≥ 0.12); however the preservation of muscle function and morphology in mdx mice indicates vibration is not deleterious to muscle lacking dystrophin. Vibrated mice had smaller subcutaneous fat pads (P = 0.03) and higher intramuscular triglyceride concentrations (P = 0.03). These data suggest that vibration training at 45 Hz and 0.6 g did not significantly impact the tibial bone and the surrounding musculature, but may influence fat distribution in mice.

  20. Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model.

    Science.gov (United States)

    Khokhlova, Tatiana D; Wang, Yak-Nam; Simon, Julianna C; Cunitz, Bryan W; Starr, Frank; Paun, Marla; Crum, Lawrence A; Bailey, Michael R; Khokhlova, Vera A

    2014-06-03

    The clinical use of high intensity focused ultrasound (HIFU) therapy for noninvasive tissue ablation has been recently gaining momentum. In HIFU, ultrasound energy from an extracorporeal source is focused within the body to ablate tissue at the focus while leaving the surrounding organs and tissues unaffected. Most HIFU therapies are designed to use heating effects resulting from the absorption of ultrasound by tissue to create a thermally coagulated treatment volume. Although this approach is often successful, it has its limitations, such as the heat sink effect caused by the presence of a large blood vessel near the treatment area or heating of the ribs in the transcostal applications. HIFU-induced bubbles provide an alternative means to destroy the target tissue by mechanical disruption or, at its extreme, local fractionation of tissue within the focal region. Here, we demonstrate the feasibility of a recently developed approach to HIFU-induced ultrasound-guided tissue fractionation in an in vivo pig model. In this approach, termed boiling histotripsy, a millimeter-sized boiling bubble is generated by ultrasound and further interacts with the ultrasound field to fractionate porcine liver tissue into subcellular debris without inducing further thermal effects. Tissue selectivity, demonstrated by boiling histotripsy, allows for the treatment of tissue immediately adjacent to major blood vessels and other connective tissue structures. Furthermore, boiling histotripsy would benefit the clinical applications, in which it is important to accelerate resorption or passage of the ablated tissue volume, diminish pressure on the surrounding organs that causes discomfort, or insert openings between tissues.

  1. Model-based scaling and prediction of the streamwise energy intensity in high-Reynolds number turbulent channels

    CERN Document Server

    Moarref, Rashad; Tropp, Joel A; McKeon, Beverley J

    2013-01-01

    We study the Reynolds number scaling of a gain-based, low-rank approximation to turbulent channel flows, determined by the resolvent formulation of McKeon & Sharma (2010), in order to obtain a description of the streamwise turbulence intensity from direct consideration of the Navier-Stokes equations. Under this formulation, the velocity field is decomposed into propagating waves (with single streamwise and spanwise wavelengths and wave speed) whose wall-normal shapes are determined from the principal singular function of the corresponding resolvent operator. We establish that the resolvent formulation admits three classes of wave parameters that induce universal behavior with Reynolds number on the low-rank model, and which are consistent with scalings proposed throughout the wall turbulence literature. For the rank-1 model subject to broadband forcing, the integrated streamwise energy density takes a universal form which is consistent with the dominant near-wall turbulent motions. When the shape of the f...

  2. A nonlinear model coupling rockfall and rainfall intensity based ewline on a four year measurement in a high Alpine rock wall (Reintal, German Alps

    Directory of Open Access Journals (Sweden)

    M. Krautblatter

    2009-08-01

    Full Text Available A total of more than 140 000 kg of small-magnitude rockfall deposits was measured in eight rockfall collectors of altogether 940 m2 in size between 1999–2003 below a 400–600 m high rock face in the Reintal, German Alps. Measurements were conducted with a temporal resolution up to single days to attribute rockfall intensity to observed triggering events. Precipitation was assessed by a rain gauge and high-resolution precipitation radar. Intense rainstorms triggered previously unreported rockfall intensities of up to 300 000 g/(m2h that we term "secondary rockfall event." In comparison to dry periods without frost (10−2g/(m2h, rockfall deposition increased by 2–218 times during wet freeze-thaw cycles and by 56-thousand to 40-million times during secondary rockfall events. We obtained three nonlinear logistic growth models that relate rockfall intensity [g/(m2h] to rainfall intensity [mm/h]. The models account for different rock wall intermediate storage volumes, triggering thresholds and storage depletion. They apply to all rockfall collector positions with correlations from R2=0.89 to 0.99. Thus, the timing of more than 90% of the encountered rockfall is explained by the triggering factor rainfall intensity. A combination of rockfall response models with radar-supported storm cell forecast could be used to anticipate hazardous rockfall events, and help to reduce the exposure of individuals and mobile structures (e.g. cable cars to the hazard. According to meteorological recordings, the frequency of these intense rockfall events is likely to increase in response to global warming.

  3. High Intensity Secondary Beams Driven by Protons

    CERN Document Server

    Galambos, John; Nagaitsev, Sergei

    2013-01-01

    As part of the Intensity Frontier effort within the 2013 Community Summer Study, a workshop on the proton machine capabilities was held (High Intensity Secondary Beams Driven by Proton Beams) April 17-20, 2013 at Brookhaven National Laboratory in Upton, NY. Primary aims of the workshop were to understand: 1) the beam requirements for proposed high intensity proton beam based measurements; 2) the capabilities of existing world-wide high power proton machines; 3) proton facility upgrade plans and proposals for new facilities; 4) and to document the R&D needs for proton accelerators and target systems needed to support proposed intensity frontier measurements. These questions are addressed in this summary.

  4. High intensity polarized electron sources

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, C.K.

    1980-10-01

    The status of the polarized electron source development program at SLAC will be reviewed. Emission currents of 60 A, corresponding to a space charge limited current density of 180 A/cm/sup 2/, have been obtained from GaAs photocathodes. Electron beam polarization 20% greater than that obtainable from GaAs cathodes has been observed from multilayer GaAs-GaAlAs structures. Work in progress to produce high beam polarization from II-IV-V/sub 2/ chalcopyrite photocathodes will also be described.

  5. Importance of fuel treatment for limiting moderate-to-high intensity fire: Findings from comparative fire modeling

    Science.gov (United States)

    Geoffrey J. Cary; Ian D. Davies; Ross A. Bradstock; Robert E. Keane; Mike D. Flannigan

    2017-01-01

    Context: Wildland fire intensity influences natural communities, soil properties, erosion, and sequestered carbon. Measuring effectiveness of fuel treatment for reducing area of higher intensity unplanned fire is argued to be more meaningful than determining effect on total unplanned area burned. Objectives...

  6. High-Intensity Proton Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Jay L. Hirshfield

    2011-12-27

    Analysis is presented for an eight-cavity proton cyclotron accelerator that could have advantages as compared with other accelerators because of its potentially high acceleration gradient. The high gradient is possible since protons orbit in a sequence of TE111 rotating mode cavities of equally diminishing frequencies with path lengths during acceleration that greatly exceed the cavity lengths. As the cavities operate at sequential harmonics of a basic repetition frequency, phase synchronism can be maintained over a relatively wide injection phase window without undue beam emittance growth. It is shown that use of radial vanes can allow cavity designs with significantly smaller radii, as compared with simple cylindrical cavities. Preliminary beam transport studies show that acceptable extraction and focusing of a proton beam after cyclic motion in this accelerator should be possible. Progress is also reported on design and tests of a four-cavity electron counterpart accelerator for experiments to study effects on beam quality arising from variations injection phase window width. This device is powered by four 500-MW pulsed amplifiers at 1500, 1800, 2100, and 2400 MHz that provide phase synchronous outputs, since they are driven from a with harmonics derived from a phase-locked 300 MHz source.

  7. Displacement analysis of diagnostic ultrasound backscatter: a methodology for characterizing, modeling, and monitoring high intensity focused ultrasound therapy.

    Science.gov (United States)

    Speyer, Gavriel; Kaczkowski, Peter J; Brayman, Andrew A; Crum, Lawrence A

    2010-07-01

    Accurate monitoring of high intensity focused ultrasound (HIFU) therapy is critical for widespread clinical use. Pulse-echo diagnostic ultrasound (DU) is known to exhibit temperature sensitivity through relative changes in time-of-flight between two sets of radio frequency (RF) backscatter measurements, one acquired before and one after therapy. These relative displacements, combined with knowledge of the exposure protocol, material properties, heat transfer, and measurement noise statistics, provide a natural framework for estimating the administered heating, and thereby therapy. The proposed method, termed displacement analysis, identifies the relative displacements using linearly independent displacement patterns, or modes, each induced by a particular time-varying heating applied during the exposure interval. These heating modes are themselves linearly independent. This relationship implies that a linear combination of displacement modes aligning the DU measurements is the response to an identical linear combination of heating modes, providing the heating estimate. Furthermore, the accuracy of coefficient estimates in this approximation is determined a priori, characterizing heating, thermal dose, and temperature estimates for any given protocol. Predicted performance is validated using simulations and experiments in alginate gel phantoms. Evidence for a spatially distributed interaction between temperature and time-of-flight changes is presented.

  8. High Intensity Interval Training: New Insights

    Institute of Scientific and Technical Information of China (English)

    Martin J.Gibala

    2008-01-01

    @@ KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief,intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.,≥90%of VO2 peak).

  9. High Intensity Exercise in Multiple Sclerosis

    DEFF Research Database (Denmark)

    Wens, Inez; Dalgas, Ulrik; Vandenabeele, Frank

    2015-01-01

    Introduction Low-to-moderate intensity exercise improves muscle contractile properties and endurance capacity in multiple sclerosis (MS). The impact of high intensity exercise remains unknown. Methods Thirty-four MS patients were randomized into a sedentary control group (SED, n = 11) and 2...

  10. High-intensity training in football.

    Science.gov (United States)

    Iaia, F Marcello; Rampinini, Ermanno; Bangsbo, Jens

    2009-09-01

    This article reviews the major physiological and performance effects of aerobic high-intensity and speed-endurance training in football, and provides insight on implementation of individual game-related physical training. Analysis and physiological measurements have revealed that modern football is highly energetically demanding, and the ability to perform repeated high-intensity work is of importance for the players. Furthermore, the most successful teams perform more high-intensity activities during a game when in possession of the ball. Hence, footballers need a high fitness level to cope with the physical demands of the game. Studies on football players have shown that 8 to 12 wk of aerobic high-intensity running training (> 85% HR(max)) leads to VO2(max) enhancement (5% to 11%), increased running economy (3% to 7%), and lower blood lactate accumulation during submaximal exercise, as well as improvements in the yo-yo intermittent recovery (YYIR) test performance (13%). Similar adaptations are observed when performing aerobic high-intensity training with small-sided games. Speed-endurance training has a positive effect on football-specific endurance, as shown by the marked improvements in the YYIR test (22% to 28%) and the ability to perform repeated sprints (approximately 2%). In conclusion, both aerobic and speed-endurance training can be used during the season to improve high-intensity intermittent exercise performance. The type and amount of training should be game related and specific to the technical, tactical, and physical demands imposed on each player.

  11. Failure to Validate a Multivariable Clinical Prediction Model to Identify Pediatric Intensive Care Unit Patients at High Risk for Candidemia.

    Science.gov (United States)

    Fisher, Brian T; Ross, Rachael K; Roilides, Emmanuel; Palazzi, Debra L; Abzug, Mark J; Hoffman, Jill A; Berman, David M; Prasad, Priya A; Localio, A Russell; Steinbach, William J; Vogiatzi, Lambrini; Dutta, Ankhi; Zaoutis, Theoklis E

    2016-12-01

    We attempted to validate a previously derived clinical prediction rule for candidemia in the pediatric intensive care unit. This multicenter case control study did not identify significant association of candidemia with most of the previously identified predictors. Additional study in larger cohorts with other predictor variables is needed. © The Author 2015. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. Evaluating the relative effectiveness of high-intensity and low-intensity models of behaviour change communication interventions for abortion care-seeking in Bihar and Jharkhand, India: a cross-sectional study.

    Science.gov (United States)

    Banerjee, Sushanta K; Andersen, Kathryn; Pearson, Erin; Warvadekar, Janardan; Khan, Danish U; Batra, Sangeeta

    2017-02-24

    This study aimed to compare the effectiveness of a high-intensity model (HIM) and a low-intensity model (LIM) of behaviour change communication interventions in Bihar and Jharkhand states of India designed to improve women's knowledge and usage of safe abortion services, as well as the dose effect of intervention exposure. We conducted two cross-sectional household surveys among married women aged 15-49 years in intervention and comparison districts. Difference-in-difference models were used to assess the efficacy of the intervention, adjusting for sociodemographic characteristics. Although both intervention types improved abortion knowledge, the HIM intervention was more effective in improving comprehensive knowledge about abortion. In particular, there were improvements in knowledge on legality of abortion (AOR=2.2; 95% CI 1.6 to 2.9) and nearby sources of safe abortion care (AOR=1.7; 95% CI 1.2 to 1.3). Higher level of exposure to abortion-related messages was related to more accurate knowledge about abortion within both intervention groups. Evidence was mixed on changes in abortion care-seeking behaviour. More work is needed to ensure that women seek safe abortion services in lieu of informal services that may be more likely to lead to postabortion complications. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  13. Photoproduction at High Energy and High Intensity

    CERN Multimedia

    2002-01-01

    The photon beam used for this programme is tagged and provides a large flux up to very high energies (150-200 GeV). It is also hadron-free, since it is obtained by a two-step conversion method. A spectrometer is designed to exploit this beam and to perform a programme of photoproduction with a high level of sensitivity (5-50 events/picobarn).\\\\ \\\\ Priority will be given to the study of processes exhibiting the point-like behaviour of the photon, especially deep inelastic Compton scattering. The spectrometer has two magnets. Charged tracks are measured by MWPC's located only in field-free regions. Three calorimeters provide a large coverage for identifying and measuring electrons and photons. An iron filter downstream identifies muons. Most of the equipment is existing and recuperated from previous experiments.

  14. High-intensity sweeteners and energy balance.

    Science.gov (United States)

    Swithers, Susan E; Martin, Ashley A; Davidson, Terry L

    2010-04-26

    Recent epidemiological evidence points to a link between a variety of negative health outcomes (e.g. metabolic syndrome, diabetes and cardiovascular disease) and the consumption of both calorically sweetened beverages and beverages sweetened with high-intensity, non-caloric sweeteners. Research on the possibility that non-nutritive sweeteners promote food intake, body weight gain, and metabolic disorders has been hindered by the lack of a physiologically-relevant model that describes the mechanistic basis for these outcomes. We have suggested that based on Pavlovian conditioning principles, consumption of non-nutritive sweeteners could result in sweet tastes no longer serving as consistent predictors of nutritive postingestive consequences. This dissociation between the sweet taste cues and the caloric consequences could lead to a decrease in the ability of sweet tastes to evoke physiological responses that serve to regulate energy balance. Using a rodent model, we have found that intake of foods or fluids containing non-nutritive sweeteners was accompanied by increased food intake, body weight gain, accumulation of body fat, and weaker caloric compensation, compared to consumption of foods and fluids containing glucose. Our research also provided evidence consistent with the hypothesis that these effects of consuming saccharin may be associated with a decrement in the ability of sweet taste to evoke thermic responses, and perhaps other physiological, cephalic phase, reflexes that are thought to help maintain energy balance.

  15. A forced running wheel system with a microcontroller that provides high-intensity exercise training in an animal ischemic stroke model

    Energy Technology Data Exchange (ETDEWEB)

    Chen, C.C. [Department of Electrical Engineering, National Cheng-Kung University, Tainan, Taiwan (China); Chang, M.W. [Department of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan (China); Chang, C.P. [Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan (China); Chan, S.C.; Chang, W.Y.; Yang, C.L. [Department of Electrical Engineering, National Cheng-Kung University, Tainan, Taiwan (China); Lin, M.T. [Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan (China)

    2014-08-15

    We developed a forced non-electric-shock running wheel (FNESRW) system that provides rats with high-intensity exercise training using automatic exercise training patterns that are controlled by a microcontroller. The proposed system successfully makes a breakthrough in the traditional motorized running wheel to allow rats to perform high-intensity training and to enable comparisons with the treadmill at the same exercise intensity without any electric shock. A polyvinyl chloride runway with a rough rubber surface was coated on the periphery of the wheel so as to permit automatic acceleration training, and which allowed the rats to run consistently at high speeds (30 m/min for 1 h). An animal ischemic stroke model was used to validate the proposed system. FNESRW, treadmill, control, and sham groups were studied. The FNESRW and treadmill groups underwent 3 weeks of endurance running training. After 3 weeks, the experiments of middle cerebral artery occlusion, the modified neurological severity score (mNSS), an inclined plane test, and triphenyltetrazolium chloride were performed to evaluate the effectiveness of the proposed platform. The proposed platform showed that enhancement of motor function, mNSS, and infarct volumes was significantly stronger in the FNESRW group than the control group (P<0.05) and similar to the treadmill group. The experimental data demonstrated that the proposed platform can be applied to test the benefit of exercise-preconditioning-induced neuroprotection using the animal stroke model. Additional advantages of the FNESRW system include stand-alone capability, independence of subjective human adjustment, and ease of use.

  16. A forced running wheel system with a microcontroller that provides high-intensity exercise training in an animal ischemic stroke model.

    Science.gov (United States)

    Chen, C C; Chang, M W; Chang, C P; Chan, S C; Chang, W Y; Yang, C L; Lin, M T

    2014-10-01

    We developed a forced non-electric-shock running wheel (FNESRW) system that provides rats with high-intensity exercise training using automatic exercise training patterns that are controlled by a microcontroller. The proposed system successfully makes a breakthrough in the traditional motorized running wheel to allow rats to perform high-intensity training and to enable comparisons with the treadmill at the same exercise intensity without any electric shock. A polyvinyl chloride runway with a rough rubber surface was coated on the periphery of the wheel so as to permit automatic acceleration training, and which allowed the rats to run consistently at high speeds (30 m/min for 1 h). An animal ischemic stroke model was used to validate the proposed system. FNESRW, treadmill, control, and sham groups were studied. The FNESRW and treadmill groups underwent 3 weeks of endurance running training. After 3 weeks, the experiments of middle cerebral artery occlusion, the modified neurological severity score (mNSS), an inclined plane test, and triphenyltetrazolium chloride were performed to evaluate the effectiveness of the proposed platform. The proposed platform showed that enhancement of motor function, mNSS, and infarct volumes was significantly stronger in the FNESRW group than the control group (P<0.05) and similar to the treadmill group. The experimental data demonstrated that the proposed platform can be applied to test the benefit of exercise-preconditioning-induced neuroprotection using the animal stroke model. Additional advantages of the FNESRW system include stand-alone capability, independence of subjective human adjustment, and ease of use.

  17. High-intensity, focused ultrasonic fields

    DEFF Research Database (Denmark)

    Jensen, Leif Bjørnø

    1988-01-01

    distribution, etc. involving nonlinearity, diffraction, and absorption in the high-intensity focused ultrasonic fields produced by an ellipsoid as well as a spherical cap focusing geometry. Data from the development of an ESWL of the piezoelectric disk type are reported including demands to transducers...

  18. Cryogenic semiconductor high-intensity radiation monitors

    CERN Document Server

    Palmieri, V G; Borer, K; Casagrande, L; Da Vià, C; Devine, S R H; Dezillie, B; Esposito, A; Granata, V; Hauler, F; Jungermann, L; Li, Z; Lourenço, C; Niinikoski, T O; O'Shea, V

    2003-01-01

    This paper describes a novel technique to monitor high-intensity particle beams by means of a semiconductor detector. It consists of cooling a semiconductor detector down to cryogenic temperature to suppress the thermally generated leakage current and to precisely measure the integrated ionization signal. It will be shown that such a device provides very good linearity and a dynamic range wider than is possible with existing techniques. Moreover, thanks to the Lazarus effect, extreme radiation hardness can be achieved providing in turn absolute intensity measurements against precise calibration of the device at low beam flux.

  19. Intensive treatment models and coercion

    DEFF Research Database (Denmark)

    Ohlenschlaeger, Johan; Thorup, Anne; Petersen, Lone;

    2007-01-01

    Little evidence exists concerning the optimal treatment for patients with first-episode schizophrenia-spectrum disorders and the effect on traditional outcomes. The aim was to investigate whether optimal treatment models have an effect on the level of use of coercion and on traditional outcomes. ...... treatment. A higher number of bed-days in Hospital-based Rehabilitation did not influence the effect on the outcomes measured........ Hospital-based Rehabilitation, an intensified inpatient treatment model, Integrated Treatment, an intensified model of Assertive Community Treatment, and standard treatment were compared for patients with first-episode schizophrenia-spectrum disorders. Ninety-four patients with first-episode schizophrenia......-spectrum disorders estimated to benefit from long-term hospitalization were included consecutively from the Copenhagen OPUS-trial and randomized to the three treatment models. At 1-year follow-up, Hospital-based Rehabilitation and Integrated Treatment had better scores on symptoms in the negative dimension...

  20. Intensive treatment models and coercion

    DEFF Research Database (Denmark)

    Ohlenschlaeger, Johan; Thorup, Anne; Petersen, Lone

    2007-01-01

    Little evidence exists concerning the optimal treatment for patients with first-episode schizophrenia-spectrum disorders and the effect on traditional outcomes. The aim was to investigate whether optimal treatment models have an effect on the level of use of coercion and on traditional outcomes...

  1. Possibility of applying a hydrodynamic model to describe the laser erosion of metals irradiated by high-intensity nanosecond pulses

    Energy Technology Data Exchange (ETDEWEB)

    Kozadaev, K V [A.N. Sevchenko Research Institute of Applied Physics Problems, Belarusian State University, Minsk (Belarus)

    2014-04-28

    We report the results of experimental investigations of the production and development of plasma-vapour plumes upon irradiation of metal targets by nanosecond (10–100 ns) pulses with a high (10{sup 8}–10{sup 10} W cm{sup -2}) power density under atmospheric conditions. The transition from a quasi-stationary thermal mechanism of metal erosion to an explosion hydrodynamic one takes place when the radiation power density increases from 10{sup 8} to 10{sup 9} W cm{sup -2}. The resultant experimental information is extremely important for the laser deposition of metal nanostructures under atmospheric conditions, which is possible only for power densities of 10{sup 8}–10{sup 9} W cm{sup -2}. (interaction of laser radiation with matter)

  2. Concept for a new high resolution high intensity diffractometer

    Energy Technology Data Exchange (ETDEWEB)

    Stuhr, U. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-09-01

    A concept of a new time-of-flight powder-diffractometer for a thermal neutral beam tube at SINQ is presented. The design of the instrument optimises the contradictory conditions of high intensity and high resolution. The high intensity is achieved by using many neutron pulses simultaneously. By analysing the time-angle-pattern of the detected neutrons an assignment of the neutrons to a single pulse is possible. (author) 3 figs., tab., refs.

  3. Exposure at Default Modeling with Default Intensities

    OpenAIRE

    Witzany, Jiří

    2011-01-01

    The paper provides an overview of the Exposure at Default (EAD) definition, requirements, and estimation methods as set by the Basel II regulation. A new methodology connected to the intensity of default modeling is proposed. The numerical examples show that various estimation techniques may lead to quite different results with intensity of default based model being recommended as the most faithful with respect to a precise probabilistic definition of the EAD parameter.

  4. Modulation of the interstitial fluid pressure by high intensity focused ultrasound as a way to alter local fluid and solute movement: insights from a mathematical model.

    Science.gov (United States)

    Sassaroli, E; O'Neill, B E

    2014-11-21

    High intensity focused ultrasound (HIFU) operated in thermal mode has been reported to reduce interstitial fluid pressure and improve the penetration of large macromolecules and nanoparticles in tumor and normal tissue. Little is understood about how the interstitial fluid pressure and velocity as well as the interstitial macromolecule transport are affected by HIFU exposure. A mathematical model is presented here which sheds light on the initial biophysical changes brought about HIFU. Our continuum model treats tissue as an effective poro-elastic material that reacts to elevated temperatures with a rapid drop in interstitial elastic modulus. Using parameters from the literature, the model is extrapolated to derive information on the effect in tumors, and to predict its impact on the convective and diffusive transport of macromolecular drugs. The model is first solved using an analytical approximation with step-wise changes at each boundary, and then solved numerically starting from a Gaussian beam approximation of the ultrasound treatment. Our results indicate that HIFU causes a rapid drop in interstitial fluid pressure that may be exploited to facilitate convection of macromolecules from vasculature to the exposed region. However, following a short recovery period in which the interstitial fluid pressure is normalized, transport returns to normal and the advantages disappear over time. The results indicate that this effect is strongest for the delivery of large molecules and nanoparticles that are in the circulation at the time of treatment. The model may be easily applied to more complex situations involving effects on vascular permeability and diffusion.

  5. Effect of continuous high intensity focused ultrasound in a squamous cell carcinoma tumor model compared to muscle tissue evaluated by MRI, histology, and gene expression.

    Science.gov (United States)

    Hundt, Walter; Yuh, Esther L; Steinbach, Silke; Bednarski, Mark D

    2009-04-01

    The purpose of this study was to investigate the effect of the continuous mode of high intensity focused ultrasound (HIFU) in a mouse head and neck cancer model (SCCVII) compared to muscle tissue. HIFU was applied to SCCVII tumors and to muscle tissue in C3H/Km mice using a dual ultrasound system (imaging 6 MHz/therapeutic 1 MHz). A continuous HIFU mode (total time 20 sec, intensity 6730.6 W/cm(2)) was applied. Three hours after HIFU treatment pre- and post-contrast T1-wt, T2-wt images, and a diffusion-wt STEAM sequence were obtained. After MR imaging, the animals were euthenized and the treated tumor and muscle tissue was taken out for histology and functional genomic analysis. T2 images showed increased signal intensity, post-contrast T1 showed a decreased contrast uptake in the central parts in the tumor tissue as well as in the muscle tissue. In addition a significant higher diffusion coefficient was found in both tissue types. Histological evaluation (H&E, Immunohistochemistry) of the tumors and the muscle tissue revealed areas of significant necrosis. In the tumor tissue 23 genes were up-regulated (> 2 fold change) and 4 genes were down-regulated (muscle tissue 29 genes were up-regulated and 17 genes down-regulated. Thirteen genes were up-regulated in both tissue types, 8 genes only in the SCCVII tissue, and 11 genes only in the muscle tissue. The use of HIFU treatment on tumor and muscle tissue results in dramatic changes in gene expression. The expression of some genes are tissue specific, the expression of other genes are independent of the tissue type.

  6. Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease.

    Science.gov (United States)

    Tucker, Patrick S; Scanlan, Aaron T; Vella, Rebecca K; Dalbo, Vincent J

    2015-06-01

    Chronic kidney disease (CKD) is an irreversible disease that diminishes length and quality of life. Emerging evidence suggests CKD progression and genomic integrity are inversely and causally related. To reduce health complications related to CKD progression, chronic aerobic exercise is often recommended. To date, appraisals of differing modes of exercise, along with postulations regarding the mechanisms responsible for observed effects, are lacking. In order to examine the ability of aerobic exercise to encourage improvements in genomic integrity, we evaluated the effects of 8 weeks of high-intensity interval training (HIIT; 85 % VO2max), low intensity training (LIT; 45-50 % VO2max), and sedentary behaviour (SED), in an animal model of early-stage CKD. To assess genomic integrity, we examined kidney-specific messenger RNA (mRNA) expression of genes related to genomic repair and stability: Fan1, Mre11a, and telomere length as measured by T/S ratio. Following HIIT, mRNA expression of Fan1 was significantly up-regulated, compared to SED (p = 0.026) and T/S ratio was significantly increased, compared to SED (p < 0.001) and LIT (p = 0.002). Our results suggest that HIIT is superior to SED and LIT as HIIT beneficially influenced the expression of genes related to genomic integrity.

  7. High Intensity Interval Training Favourably Affects Angiotensinogen mRNA Expression and Markers of Cardiorenal Health in a Rat Model of Early-Stage Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Patrick S. Tucker

    2015-01-01

    Full Text Available The majority of CKD-related complications stem from cardiovascular pathologies such as hypertension. To help reduce cardiovascular complications, aerobic exercise is often prescribed. Emerging evidence suggests high intensity interval training (HIIT may be more beneficial than traditional aerobic exercise. However, appraisals of varying forms of aerobic exercise, along with descriptions of mechanisms responsible for health-related improvements, are lacking. This study examined the effects of 8 weeks of HIIT (85% VO2max, versus low intensity aerobic exercise (LIT; 45–50% VO2max and sedentary behaviour (SED, in an animal model of early-stage CKD. Tissue-specific mRNA expression of RAAS-related genes and CKD-related clinical markers were examined. Compared to SED, HIIT resulted in increased plasma albumin (p=0.001, reduced remnant kidney weight (p=0.028, and reduced kidney weight-body weight ratios (p=0.045. Compared to LIT, HIIT resulted in reduced Agt mRNA expression (p=0.035, reduced plasma LDL (p=0.001, triglycerides (p=0.029, and total cholesterol (p=0.002, increased plasma albumin (p=0.047, reduced remnant kidney weight (p=0.005, and reduced kidney weight-body weight ratios (p=0.048. These results suggest HIIT is a more potent regulator of several markers that describe and influence health in CKD.

  8. The high intensity neutron source FRANZ

    CERN Document Server

    Lederer, Claudia

    2014-01-01

    The Frankfurt neutron source of Stern Gerlach Zentrum FRANZ is currently under construction at the University of Frankfurt. At FRANZ, a high intensity neutron beam in the keV energy region will be produced by bombarding a $^7$Li target with a proton beam of several mA. These unprecedented high neutron fluxes will allow a number of neutron induced cross section measurements for the first time. Measurements can be performed by the time-of-flight and by the activation technique.

  9. Effects of High-Intensity Swimming on Lung Inflammation and Oxidative Stress in a Murine Model of DEP-Induced Injury.

    Directory of Open Access Journals (Sweden)

    Leonardo C M Ávila

    Full Text Available Studies have reported that exposure to diesel exhaust particles (DEPs induces lung inflammation and increases oxidative stress, and both effects are susceptible to changes via regular aerobic exercise in rehabilitation programs. However, the effects of exercise on lungs exposed to DEP after the cessation of exercise are not clear. Therefore, the aim of this study was to evaluate the effects of high-intensity swimming on lung inflammation and oxidative stress in mice exposed to DEP concomitantly and after exercise cessation. Male Swiss mice were divided into 4 groups: Control (n = 12, Swimming (30 min/day (n = 8, DEP (3 mg/mL-10 μL/mouse (n = 9 and DEP+Swimming (n = 8. The high-intensity swimming was characterized by an increase in blood lactate levels greater than 1 mmoL/L between 10th and 30th minutes of exercise. Twenty-four hours after the final exposure to DEP, the anesthetized mice were euthanized, and we counted the number of total and differential inflammatory cells in the bronchoalveolar fluid (BALF, measured the lung homogenate levels of IL-1β, TNF-α, IL-6, INF-ϫ, IL-10, and IL-1ra using ELISA, and measured the levels of glutathione, non-protein thiols (GSH-t and NPSH and the antioxidant enzymes catalase and glutathione peroxidase (GPx in the lung. Swimming sessions decreased the number of total cells (p<0.001, neutrophils and lymphocytes (p<0.001; p<0.05 in the BALF, as well as lung levels of IL-1β (p = 0.002, TNF-α (p = 0.003, IL-6 (p = 0.0001 and IFN-ϫ (p = 0.0001. However, the levels of IL-10 (p = 0.01 and IL-1ra (p = 0.0002 increased in the swimming groups compared with the control groups, as did the CAT lung levels (p = 0.0001. Simultaneously, swimming resulted in an increase in the GSH-t and NPSH lung levels in the DEP group (p = 0.0001 and p<0.002. We concluded that in this experimental model, the high-intensity swimming sessions decreased the lung inflammation and oxidative stress status during DEP-induced lung

  10. Elucidation of the role of biological factors and device design in cerebral NIRS using an in vivo hematoma model based on high-intensity focused ultrasound

    Science.gov (United States)

    Wang, Jianting; Huang, Stanley; Myers, Matthew; Chen, Yu; Welle, Cristin; Pfefer, Joshua

    2016-03-01

    Near-Infrared Spectroscopy (NIRS) is an emerging medical countermeasure for rapid, field detection of hematomas caused by traumatic brain injury (TBI). Bench and animal tests to determine NIRS sensitivity and specificity are needed. However, current animal models involving non-invasively induced, localized neural damage are limited. We investigated an in vivo murine hematoma model in which cerebral hemorrhage was induced noninvasively by high-intensity focused ultrasound (HIFU) with calibrated positioning and parameters. To characterize the morphology of induced hematomas, we used skull-intact histological evaluation. A multi-wavelength fiber-optic NIRS system with three source-detector separation distances was used to detect hematoma A 1.1 MHz transducer produced consistent small-to-medium hematoma localized to a single hemisphere, along with bruising of the scalp, with a low mortality rate. A 220 kHz transducer produced larger, more diffuse hematomas, with higher variability in size and a correspondingly higher mortality rate. No skin bruising or blood accumulation between the skin and skull was observed following injury application with the 220 kHz transducer. Histological analysis showed higher sensitivity for larger hematomas (>4x4 mm2). NIRS optical density change after HIFU was able to detect all hematomas, with sensitivity dependent on wavelength and separation distance. While improvements in methods for validating cerebral blood distribution are needed, the HIFU hematoma model provided useful insights that will inform development of biologically relevant, performance test methods for cerebral NIRS systems.

  11. High intensity specular reflectometry - first experiments

    CERN Document Server

    Stahn, J; Panzner, T

    2011-01-01

    Selene is the attempt to implement a new scheme for high-intensity specular reflectometry. Instead of a highly collimated beam one uses a convergent beam covering a large angular range. The angular resolution is then performed by a position-sensitive detector. Off-specular scattering in this set-up leads to some background, but for screening of wide parameter ranges (e.g. temperature, electric and magnetic fields) the intensity gain of at least one order of magnitude is essential. If necessary, the high precession measurements (even with off-specular components) then are performed with the conventional set-up. The heart of this new set-up is an elliptically focusing guide element of 2\\,m length. Though this guide is optimised for the use on the TOF reflectometer Amor at SINQ, it can be used as stand-alone device to check the possible application also for other neutron scattering techniques. The first measurements on AMOR confirmed the general concept and the various operation modes. A draw-back occurred due t...

  12. High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension.

    Science.gov (United States)

    Brown, Mary Beth; Neves, Evandro; Long, Gary; Graber, Jeremy; Gladish, Brett; Wiseman, Andrew; Owens, Matthew; Fisher, Amanda J; Presson, Robert G; Petrache, Irina; Kline, Jeffrey; Lahm, Tim

    2017-02-01

    Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive right ventricle (RV) hypertrophy associated with the disease. For chronic left ventricle failure, high-intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute and chronic responses to HIIT vs. CExT in a rat model of monocrotaline (MCT)-induced mild PAH. Six weeks of treadmill training (5 times/wk) were performed, as either 30 min HIIT or 60 min low-intensity CExT. To characterize acute hemodynamic responses to the two approaches, novel recordings of simultaneous pulmonary and systemic pressures during running were obtained at pre- and 2, 4, 6, and 8 wk post-MCT using long-term implantable telemetry. MCT-induced decrement in maximal aerobic capacity was ameliorated by both HIIT and CExT, with less pronounced pulmonary vascular remodeling and no increase in RV inflammation or apoptosis observed. Most importantly, only HIIT lowered RV systolic pressure, RV hypertrophy, and total pulmonary resistance, and prompted higher cardiac index that was complemented by a RV increase in the positive inotrope apelin and reduced fibrosis. HIIT prompted a markedly pulsatile pulmonary pressure during running and was associated with greater lung endothelial nitric oxide synthase after 6 wk. We conclude that HIIT may be superior to CExT for improving hemodynamics and maladaptive RV hypertrophy in PAH. HIIT's superior outcomes may be explained by more favorable pulmonary vascular endothelial adaptation to the pulsatile HIIT stimulus.

  13. Workload modelling for data-intensive systems

    CERN Document Server

    Lassnig, Mario

    This thesis presents a comprehensive study built upon the requirements of a global data-intensive system, built for the ATLAS Experiment at CERN's Large Hadron Collider. First, a scalable method is described to capture distributed data management operations in a non-intrusive way. These operations are collected into a globally synchronised sequence of events, the workload. A comparative analysis of this new data-intensive workload against existing computational workloads is conducted, leading to the discovery of the importance of descriptive attributes in the operations. Existing computational workload models only consider the arrival rates of operations, however, in data-intensive systems the correlations between attributes play a central role. Furthermore, the detrimental effect of rapid correlated arrivals, so called bursts, is assessed. A model is proposed that can learn burst behaviour from captured workload, and in turn forecast potential future bursts. To help with the creation of a full representative...

  14. Forward modeling of gyrosynchrotron intensity perturbations by sausage modes

    Energy Technology Data Exchange (ETDEWEB)

    Reznikova, V. E.; Van Doorsselaere, T. [Centre for Mathematical Plasma Astrophysics, Department of Mathematics, KU Leuven, Celestijnenlaan 200B box 2400, B-3001 Leuven (Belgium); Antolin, P., E-mail: Veronika.Reznikova@wis.kuleuven.be [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan)

    2014-04-20

    To determine the observable radio signatures of the fast sausage standing wave, we examine gyrosynchrotron (GS) emission modulation using a linear three-dimensional magnetohydrodynamic model of a plasma cylinder. Effects of the line-of-sight angle and instrumental resolution on perturbations of the GS intensity are analyzed for two models: a base model with strong Razin suppression and a low-density model in which the Razin effect was unimportant. Our finding contradicts previous predictions made with simpler models: an in-phase variation of intensity between low (f < f {sub peak}) and high (f > f {sub peak}) frequencies is found for the low-density model and an anti-phase variation for the base model in the case of a viewing angle of 45°. The spatially inhomogeneous character of the oscillating emission source and the spatial resolution of the model are found to have a significant effect on the resulting intensity.

  15. High Intensity High Charge State ECR Ion Sources

    CERN Document Server

    Leitner, Daniela

    2005-01-01

    The next-generation heavy ion beam accelerators such as the proposed Rare Isotope Accelerator (RIA), the Radioactive Ion Beam Factory at RIKEN, the GSI upgrade project, the LHC-upgrade, and IMP in Lanzhou require a great variety of high charge state ion beams with a magnitude higher beam intensity than currently achievable. High performance Electron Cyclotron Resonance (ECR) ion sources can provide the flexibility since they can routinely produce beams from hydrogen to uranium. Over the last three decades, ECR ion sources have continued improving the available ion beam intensities by increasing the magnetic fields and ECR heating frequencies to enhance the confinement and the plasma density. With advances in superconducting magnet technology, a new generation of high field superconducting sources is now emerging, designed to meet the requirements of these next generation accelerator projects. The talk will briefly review the field of high performance ECR ion sources and the latest developments for high intens...

  16. Benefits of High-Intensity Intensive Care Unit Physician Staffing under the Affordable Care Act

    Directory of Open Access Journals (Sweden)

    Sachin Logani

    2011-01-01

    Full Text Available The Affordable Care Act signed into law by President Obama, with its value-based purchasing program, is designed to link payment to quality processes and outcomes. Treatment of critically ill patients represents nearly 1% of the gross domestic product and 25% of a typical hospital budget. Data suggest that high-intensity staffing patterns in the intensive care unit (ICU are associated with cost savings and improved outcomes. We evaluate the literature investigating the cost-effectiveness and clinical outcomes of high-intensity ICU physician staffing as recommended by The Leapfrog Group (a consortium of companies that purchase health care for their employees and identify ways to overcome barriers to nationwide implementation of these standards. Hospitals that have implemented the Leapfrog initiative have demonstrated reductions in mortality and length of stay and increased cost savings. High-intensity staffing models appear to be an immediate cost-effective way for hospitals to meet the challenges of health care reform.

  17. High intensity neutrino oscillation facilities in Europe

    CERN Document Server

    Edgecock, T R; Davenne, T; Densham, C; Fitton, M; Kelliher, D; Loveridge, P; Machida, S; Prior, C; Rogers, C; Rooney, M; Thomason, J; Wilcox, D; Wildner, E; Efthymiopoulos, I; Garoby, R; Gilardoni, S; Hansen, C; Benedetto, E; Jensen, E; Kosmicki, A; Martini, M; Osborne, J; Prior, G; Stora, T; Melo-Mendonca, T; Vlachoudis, V; Waaijer, C; Cupial, P; Chancé, A; Longhin, A; Payet, J; Zito, M; Baussan, E; Bobeth, C; Bouquerel, E; Dracos, M; Gaudiot, G; Lepers, B; Osswald, F; Poussot, P; Vassilopoulos, N; Wurtz, J; Zeter, V; Bielski, J; Kozien, M; Lacny, L; Skoczen, B; Szybinski, B; Ustrycka, A; Wroblewski, A; Marie-Jeanne, M; Balint, P; Fourel, C; Giraud, J; Jacob, J; Lamy, T; Latrasse, L; Sortais, P; Thuillier, T; Mitrofanov, S; Loiselet, M; Keutgen, Th; Delbar, Th; Debray, F; Trophine, C; Veys, S; Daversin, C; Zorin, V; Izotov, I; Skalyga, V; Burt, G; Dexter, A C; Kravchuk, V L; Marchi, T; Cinausero, M; Gramegna, F; De Angelis, G; Prete, G; Collazuol, G; Laveder, M; Mazzocco, M; Mezzetto, M; Signorini, C; Vardaci, E; Di Nitto, A; Brondi, A; La Rana, G; Migliozzi, P; Moro, R; Palladino, V; Gelli, N; Berkovits, D; Hass, M; Hirsh, T Y; Schaumann, M; Stahl, A; Wehner, J; Bross, A; Kopp, J; Neuffer, D; Wands, R; Bayes, R; Laing, A; Soler, P; Agarwalla, S K; Villanueva, A Cervera; Donini, A; Ghosh, T; Cadenas, J J Gómez; Hernández, P; Martín-Albo, J; Mena, O; Burguet-Castell, J; Agostino, L; Buizza-Avanzini, M; Marafini, M; Patzak, T; Tonazzo, A; Duchesneau, D; Mosca, L; Bogomilov, M; Karadzhov, Y; Matev, R; Tsenov, R; Akhmedov, E; Blennow, M; Lindner, M; Schwetz, T; Martinez, E Fernández; Maltoni, M; Menéndez, J; Giunti, C; García, M C González; Salvado, J; Coloma, P; Huber, P; Li, T; López-Pavón, J; Orme, C; Pascoli, S; Meloni, D; Tang, J; Winter, W; Ohlsson, T; Zhang, H; Scotto-Lavina, L; Terranova, F; Bonesini, M; Tortora, L; Alekou, A; Aslaninejad, M; Bontoiu, C; Kurup, A; Jenner, L J; Long, K; Pasternak, J; Pozimski, J; Back, J J; Harrison, P; Beard, K; Bogacz, A; Berg, J S; Stratakis, D; Witte, H; Snopok, P; Bliss, N; Cordwell, M; Moss, A; Pattalwar, S; Apollonio, M

    2013-01-01

    The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fr\\'ejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of {\\mu}+ and {\\mu}- beams in a storage ring. The far detector in this case is a 100 kt Magnetised Iron Neutrino Detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular 6He and 18Ne, also stored in a ring. The far detector is also the MEMPHYS detector in the Fr\\'ejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the ph...

  18. High intensity neutrino oscillation facilities in Europe

    CERN Document Server

    Edgecock, T.R.; Davenne, T.; Densham, C.; Fitton, M.; Kelliher, D.; Loveridge, P.; Machida, S.; Prior, C.; Rogers, C.; Rooney, M.; Thomason, J.; Wilcox, D.; Wildner, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoni, S.; Hansen, C.; Benedetto, E.; Jensen, E.; Kosmicki, A.; Martini, M.; Osborne, J.; Prior, G.; Stora, T.; Melo-Mendonca, T.; Vlachoudis, V.; Waaijer, C.; Cupial, P.; Chancé, A.; Longhin, A.; Payet, J.; Zito, M.; Baussan, E.; Bobeth, C.; Bouquerel, E.; Dracos, M.; Gaudiot, G.; Lepers, B.; Osswald, F.; Poussot, P.; Vassilopoulos, N.; Wurtz, J.; Zeter, V.; Bielski, J.; Kozien, M.; Lacny, L.; Skoczen, B.; Szybinski, B.; Ustrzycka, A.; Wroblewski, A.; Marie-Jeanne, M.; Balint, P.; Fourel, C.; Giraud, J.; Jacob, J.; Lamy, T.; Latrasse, L.; Sortais, P.; Thuillier, T.; Mitrofanov, S.; Loiselet, M.; Keutgen, Th.; Delbar, Th.; Debray, F.; Trophine, C.; Veys, S.; Daversin, C.; Zorin, V.; Izotov, I.; Skalyga, V.; Burt, G.; Dexter, A.C.; Kravchuk, V.L.; Marchi, T.; Cinausero, M.; Gramegna, F.; De Angelis, G.; Prete, G.; Collazuol, G.; Laveder, M.; Mazzocco, M.; Mezzetto, M.; Signorini, C.; Vardaci, E.; Di Nitto, A.; Brondi, A.; La Rana, G.; Migliozzi, P.; Moro, R.; Palladino, V.; Gelli, N.; Berkovits, D.; Hass, M.; Hirsh, T.Y.; Schaumann, M.; Stahl, A.; Wehner, J.; Bross, A.; Kopp, J.; Neuffer, D.; Wands, R.; Bayes, R.; Laing, A.; Soler, P.; Agarwalla, S.K.; Cervera Villanueva, A.; Donini, A.; Ghosh, T.; Gómez Cadenas, J.J.; Hernández, P.; Martín-Albo, J.; Mena, O.; Burguet-Castell, J.; Agostino, L.; Buizza-Avanzini, M.; Marafini, M.; Patzak, T.; Tonazzo, A.; Duchesneau, D.; Mosca, L.; Bogomilov, M.; Karadzhov, Y.; Matev, R.; Tsenov, R.; Akhmedov, E.; Blennow, M.; Lindner, M.; Schwetz, T.; Fernández Martinez, E.; Maltoni, M.; Menéndez, J.; Giunti, C.; González García, M. C.; Salvado, J.; Coloma, P.; Huber, P.; Li, T.; López-Pavón, J.; Orme, C.; Pascoli, S.; Meloni, D.; Tang, J.; Winter, W.; Ohlsson, T.; Zhang, H.; Scotto-Lavina, L.; Terranova, F.; Bonesini, M.; Tortora, L.; Alekou, A.; Aslaninejad, M.; Bontoiu, C.; Kurup, A.; Jenner, L.J.; Long, K.; Pasternak, J.; Pozimski, J.; Back, J.J.; Harrison, P.; Beard, K.; Bogacz, A.; Berg, J.S.; Stratakis, D.; Witte, H.; Snopok, P.; Bliss, N.; Cordwell, M.; Moss, A.; Pattalwar, S.; Apollonio, M.

    2013-02-20

    The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fr\\'ejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of {\\mu}+ and {\\mu}- beams in a storage ring. The far detector in this case is a 100 kt Magnetised Iron Neutrino Detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular 6He and 18Ne, also stored in a ring. The far detector is also the MEMPHYS detector in the Fr\\'ejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the ph...

  19. High intensity neutrino oscillation facilities in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Edgecock, T. R.; Caretta, O.; Davenne, T.; Densam, C.; Fitton, M.; Kelliher, D.; Loveridge, P.; Machida, S.; Prior, C.; Rogers, C.; Rooney, M.; Thomason, J.; Wilcox, D.; Wildner, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoni, S.; Hansen, C.; Benedetto, E.; Jensen, E.; Kosmicki, A.; Martini, M.; Osborne, J.; Prior, G.; Stora, T.; Melo Mendonca, T.; Vlachoudis, V.; Waaijer, C.; Cupial, P.; Chancé, A.; Longhin, A.; Payet, J.; Zito, M.; Baussan, E.; Bobeth, C.; Bouquerel, E.; Dracos, M.; Gaudiot, G.; Lepers, B.; Osswald, F.; Poussot, P.; Vassilopoulos, N.; Wurtz, J.; Zeter, V.; Bielski, J.; Kozien, M.; Lacny, L.; Skoczen, B.; Szybinski, B.; Ustrycka, A.; Wroblewski, A.; Marie-Jeanne, M.; Balint, P.; Fourel, C.; Giraud, J.; Jacob, J.; Lamy, T.; Latrasse, L.; Sortais, P.; Thuillier, T.; Mitrofanov, S.; Loiselet, M.; Keutgen, Th.; Delbar, Th.; Debray, F.; Trophine, C.; Veys, S.; Daversin, C.; Zorin, V.; Izotov, I.; Skalyga, V.; Burt, G.; Dexter, A. C.; Kravchuk, V. L.; Marchi, T.; Cinausero, M.; Gramegna, F.; De Angelis, G.; Prete, G.; Collazuol, G.; Laveder, M.; Mazzocco, M.; Mezzetto, M.; Signorini, C.; Vardaci, E.; Di Nitto, A.; Brondi, A.; La Rana, G.; Migliozzi, P.; Moro, R.; Palladino, V.; Gelli, N.; Berkovits, D.; Hass, M.; Hirsh, T. Y.; Schaumann, M.; Stahl, A.; Wehner, J.; Bross, A.; Kopp, J.; Neuffer, D.; Wands, R.; Bayes, R.; Laing, A.; Soler, P.; Agarwalla, S. K.; Cervera Villanueva, A.; Donini, A.; Ghosh, T.; Gómez Cadenas, J. J.; Hernández, P.; Martín-Albo, J.; Mena, O.; Burguet-Castell, J.; Agostino, L.; Buizza-Avanzini, M.; Marafini, M.; Patzak, T.; Tonazzo, A.; Duchesneau, D.; Mosca, L.; Bogomilov, M.; Karadzhov, Y.; Matev, R.; Tsenov, R.; Akhmedov, E.; Blennow, M.; Lindner, M.; Schwetz, T.; Fernández Martinez, E.; Maltoni, M.; Menéndez, J.; Giunti, C.; González García, M. C.; Salvado, J.; Coloma, P.; Huber, P.; Li, T.; López Pavón, J.; Orme, C.; Pascoli, S.; Meloni, D.; Tang, J.; Winter, W.; Ohlsson, T.; Zhang, H.; Scotto-Lavina, L.; Terranova, F.; Bonesini, M.; Tortora, L.; Alekou, A.; Aslaninejad, M.; Bontoiu, C.; Kurup, A.; Jenner, L. J.; Long, K.; Pasternak, J.; Pozimski, J.; Back, J. J.; Harrison, P.; Beard, K.; Bogacz, A.; Berg, J. S.; Stratakis, D.; Witte, H.; Snopok, P.; Bliss, N.; Cordwell, M.; Moss, A.; Pattalwar, S.; Apollonio, M.

    2013-02-01

    The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fr\\'ejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of {\\mu}+ and {\\mu}- beams in a storage ring. The far detector in this case is a 100 kt Magnetised Iron Neutrino Detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular 6He and 18Ne, also stored in a ring. The far detector is also the MEMPHYS detector in the Fr\\'ejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive.

  20. Towards optical intensity interferometry for high angular resolution stellar astrophysics

    CERN Document Server

    Nunez, Paul D

    2012-01-01

    Most neighboring stars are still detected as point sources and are beyond the angular resolution reach of current observatories. Methods to improve our understanding of stars at high angular resolution are investigated. Air Cherenkov telescopes (ACTs), primarily used for Gamma-ray astronomy, enable us to increase our understanding of the circumstellar environment of a particular system. When used as optical intensity interferometers, future ACT arrays will allow us to detect stars as extended objects and image their surfaces at high angular resolution. Optical stellar intensity interferometry (SII) with ACT arrays, composed of nearly 100 telescopes, will provide means to measure fundamental stellar parameters and also open the possibility of model-independent imaging. A data analysis algorithm is developed and permits the reconstruction of high angular resolution images from simulated SII data. The capabilities and limitations of future ACT arrays used for high angular resolution imaging are investigated via ...

  1. Physics of intense, high energy radiation effects.

    Energy Technology Data Exchange (ETDEWEB)

    Hjalmarson, Harold Paul; Hartman, E. Frederick; Magyar, Rudolph J.; Crozier, Paul Stewart

    2011-02-01

    This document summarizes the work done in our three-year LDRD project titled 'Physics of Intense, High Energy Radiation Effects.' This LDRD is focused on electrical effects of ionizing radiation at high dose-rates. One major thrust throughout the project has been the radiation-induced conductivity (RIC) produced by the ionizing radiation. Another important consideration has been the electrical effect of dose-enhanced radiation. This transient effect can produce an electromagnetic pulse (EMP). The unifying theme of the project has been the dielectric function. This quantity contains much of the physics covered in this project. For example, the work on transient electrical effects in radiation-induced conductivity (RIC) has been a key focus for the work on the EMP effects. This physics in contained in the dielectric function, which can also be expressed as a conductivity. The transient defects created during a radiation event are also contained, in principle. The energy loss lead the hot electrons and holes is given by the stopping power of ionizing radiation. This information is given by the inverse dielectric function. Finally, the short time atomistic phenomena caused by ionizing radiation can also be considered to be contained within the dielectric function. During the LDRD, meetings about the work were held every week. These discussions involved theorists, experimentalists and engineers. These discussions branched out into the work done in other projects. For example, the work on EMP effects had influence on another project focused on such phenomena in gases. Furthermore, the physics of radiation detectors and radiation dosimeters was often discussed, and these discussions had impact on related projects. Some LDRD-related documents are now stored on a sharepoint site (https://sharepoint.sandia.gov/sites/LDRD-REMS/default.aspx). In the remainder of this document the work is described in catergories but there is much overlap between the atomistic

  2. High intensity neutrino oscillation facilities in Europe

    Directory of Open Access Journals (Sweden)

    T. R. Edgecock

    2013-02-01

    Full Text Available The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fréjus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of μ^{+} and μ^{-} beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular ^{6}He and ^{18}Ne, also stored in a ring. The far detector is also the MEMPHYS detector in the Fréjus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive.

  3. High-Intensity, High Charge-State Heavy Ion Sources

    CERN Document Server

    Alessi, J

    2004-01-01

    There are many accelerator applications for high intensity heavy ion sources, with recent needs including dc beams for RIA, and pulsed beams for injection into synchrotrons such as RHIC and LHC. The present status of sources producing high currents of high charge state heavy ions will be reviewed. These sources include ECR, EBIS, and Laser ion sources. The benefits and limitations for these type sources will be described, for both dc and pulsed applications. Possible future improvements in these type sources will also be discussed.

  4. High-Intensity Synchrotron Radiation Effects

    CERN Document Server

    Suetsugu, Y

    2016-01-01

    Various effects of intense synchrotron radiation on the performance of particle accelerators, especially for storage rings, are discussed. Following a brief introduction to synchrotron radiation, the basic concepts of heat load, gas load, electron emission, and the countermeasures against these effects are discussed.

  5. A PRACTICAL MODEL OF LOW-VOLUME HIGH-INTENSITY INTERVAL TRAINING INDUCES PERFORMANCE AND METABOLIC ADAPTATIONS THAT RESEMBLE 'ALL-OUT' SPRINT INTERVAL TRAINING

    Directory of Open Access Journals (Sweden)

    Mahdi Bayati

    2011-09-01

    Full Text Available Recently, a novel type of high-intensity interval training known as sprint interval training has demonstrated increases in aerobic and anaerobic performance with very low time commitment. However, this type of training program is unpractical for general populations. The present study compared the impact of a low-volume high-intensity interval training to a "all-out" sprint interval training. Twenty-four active young males were recruited and randomized into three groups: (G1: 3-5 cycling bouts × 30-s all-out with 4 min recovery; G2: 6- 10 cycling bouts × 125% Pmax with 2 min recovery and a non-trained control group. They all performed a VO2max test, a time to exhaustion at Pmax (Tmax and a Wingate test before and after the intervention. Capillary blood lactate was taken at rest, 3, and 20 min after the Wingate trial. Training was performed 3 sessions per week for 4 weeks. In G1, significant improvements (p < 0.05 following training were found in VO2max (9.6%, power at VO2max (12.8%, Tmax (48.4%, peak power output (10.3% and mean power output (17.1%. In G2, significant improvements following training were found in VO2max (9.7%, power at VO2max (16.1%, Tmax (54.2%, peak power output (7.4%; p < 0.05, but mean power output did not change significantly. Blood lactate recovery (20th min significantly decreased in G1 and G2 when compared with pre-testing and the CON group (p < 0.05. In conclusion, the results of the current study agree with earlier work demonstrating the effectiveness of 30-s all-out training program to aerobic and anaerobic adaptations. Of substantial interest is that the low volume high intensity training provides similar results but involves only half the intensity with double the repetitions

  6. Efficacy of high intensity atorvastatin versus moderate intensity atorvastatin for acute coronary syndrome patients with diabetes mellitus.

    Science.gov (United States)

    Liu, Zhi; Xu, Yueqiao; Hao, Hengjian; Yin, Chunlin; Xu, Ji; Li, Jing; Wang, Yanling; Xu, Dong

    2016-11-01

    To investigate whether more benefits can be achieved through high intensity atorvastatin compared with moderate intensity atorvastatin in acute coronary syndrome (ACS) patients with diabetes mellitus (DM). This was a randomized controlled trail. Total 591 ACS patients with DM who underwent percutaneous coronary intervention were enrolled, 297 in high intensity atorvastatin group (40mg/day) and 294 in moderate intensity atorvastatin group (20mg/day). The primary end point was one-year incidence of major adverse cardiovascular events (MACE, including cardiovascular death, spontaneous myocardial infarction, unplanned revascularization). Cox proportional hazard regression models were used to analyze the association between clinical endpoints and atorvastatin treatment. At the end of one-year, low-density lipoprotein cholesterol level was lower in high intensity group than in moderate group (1.6±0.6 vs 1.8±0.6, p=0.041). MACE in high intensity group decreased 44.5% than moderate group (8.4% vs. 14.6%, p=0.018). The adjusted hazard ratio (HR) for MACE in patients with atorvastatin 40mg/d was lower compared to patients with atorvastatin 20mg/d (HR [95% CI] 0.61 [0.36 to 0.91], p=0.026). The rates of adverse events were no significantly different between the two groups. For ACS patients with DM, high intensity atorvastatin induced better long-term outcomes compared with moderate intensity. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  7. Stretching Effects: High-intensity & Moderate-duration vs. Low-intensity & Long-duration.

    Science.gov (United States)

    Freitas, S R; Vaz, J R; Bruno, P M; Andrade, R; Mil-Homens, P

    2016-03-01

    This study examined whether a high-intensity, moderate-duration bout of stretching would produce the same acute effects as a low-intensity, long-duration bout of stretching. 17 volunteers performed 2 knee-flexor stretching protocols: a high-intensity stretch (i. e., 100% of maximum tolerable passive torque) with a moderate duration (243.5 ± 69.5-s); and a low-intensity stretch (50% of tolerable passive torque) with a long duration (900-s). Passive torque at a given sub-maximal angle, peak passive torque, maximal range of motion (ROM), and muscle activity were assessed before and after each stretching protocol (at intervals of 1, 30 and 60 min). The maximal ROM and tolerable passive torque increased for all time points following the high-intensity stretching (p0.05). 1 min post-stretching, the passive torque decreased in both protocols, but to a greater extent in the low-intensity protocol. 30 min post-test, torque returned to baseline for the low-intensity protocol and had increased above the baseline for the high-intensity stretches. The following can be concluded: 1) High-intensity stretching increases the maximal ROM and peak passive torque compared to low-intensity stretching; 2) low-intensity, long-duration stretching is the best way to acutely decrease passive torque; and 3) high-intensity, moderate-duration stretching increases passive torque above the baseline 30 min after stretching. © Georg Thieme Verlag KG Stuttgart · New York.

  8. Modelling background intensity in Affymetrix Genechips

    CERN Document Server

    Kroll, K M; Carlon, E

    2008-01-01

    DNA microarrays are devices that are able, in principle, to detect and quantify the presence of specific nucleic acid sequences in complex biological mixtures. The measurement consists in detecting fluorescence signals from several spots on the microarray surface onto which different probe sequences are grafted. One of the problems of the data analysis is that the signal contains a noisy background component due to non-specific binding. This paper presents a physical model for background estimation in Affymetrix Genechips. It combines two different approaches. The first is based on the sequence composition, specifically its sequence dependent hybridization affinity. The second is based on the strong correlation of intensities from locations which are the physical neighbors of a specific spot on the chip. Both effects are incorporated in a background functional which contains 24 free parameters, fixed by minimization on a training data set. In all data analyzed the sequence specific parameters, obtained by min...

  9. Effects of High-Intensity Swimming on Lung Inflammation and Oxidative Stress in a Murine Model of DEP-Induced Injury.

    Science.gov (United States)

    Ávila, Leonardo C M; Bruggemann, Thayse R; Bobinski, Franciane; da Silva, Morgana Duarte; Oliveira, Regiane Carvalho; Martins, Daniel Fernandes; Mazzardo-Martins, Leidiane; Duarte, Marta Maria Medeiros Frescura; de Souza, Luiz Felipe; Dafre, Alcir; Vieira, Rodolfo de Paula; Santos, Adair Roberto Soares; Bonorino, Kelly Cattelan; Hizume Kunzler, Deborah de C

    2015-01-01

    Studies have reported that exposure to diesel exhaust particles (DEPs) induces lung inflammation and increases oxidative stress, and both effects are susceptible to changes via regular aerobic exercise in rehabilitation programs. However, the effects of exercise on lungs exposed to DEP after the cessation of exercise are not clear. Therefore, the aim of this study was to evaluate the effects of high-intensity swimming on lung inflammation and oxidative stress in mice exposed to DEP concomitantly and after exercise cessation. Male Swiss mice were divided into 4 groups: Control (n = 12), Swimming (30 min/day) (n = 8), DEP (3 mg/mL-10 μL/mouse) (n = 9) and DEP+Swimming (n = 8). The high-intensity swimming was characterized by an increase in blood lactate levels greater than 1 mmoL/L between 10th and 30th minutes of exercise. Twenty-four hours after the final exposure to DEP, the anesthetized mice were euthanized, and we counted the number of total and differential inflammatory cells in the bronchoalveolar fluid (BALF), measured the lung homogenate levels of IL-1β, TNF-α, IL-6, INF-ϫ, IL-10, and IL-1ra using ELISA, and measured the levels of glutathione, non-protein thiols (GSH-t and NPSH) and the antioxidant enzymes catalase and glutathione peroxidase (GPx) in the lung. Swimming sessions decreased the number of total cells (pswimming groups compared with the control groups, as did the CAT lung levels (p = 0.0001). Simultaneously, swimming resulted in an increase in the GSH-t and NPSH lung levels in the DEP group (p = 0.0001 and pswimming sessions decreased the lung inflammation and oxidative stress status during DEP-induced lung inflammation in mice.

  10. Is high-intensity exercise better than moderate-intensity exercise for weight loss?

    Science.gov (United States)

    De Feo, P

    2013-11-01

    This viewpoint debates the state-of-the-art research focusing on the optimal intensity of the exercise programs for inducing a sustained weight or fat-mass loss in overweight/obese people. In our demanding society, the most attractive messages in the popular press are those promising the best results in a short time. This might explain the emphasis given by media to those scientific articles that report the efficacy on weight loss of exercise programs by their shorter duration and higher intensity. However, in the literature on overweight or obese people, there is little conclusive evidence for more favorable effects with high-intensity training than with continuous moderate-intensity exercise on body weight or fat mass loss. Since both exercise protocols have been demonstrated as useful to reduce body weight, the decision on the intensity of exercise prescription should be individualized and based on outcomes different from fat or weight loss. In this regard, there are pro and contra arguments for the prescription of high-intensity aerobic exercise in obese people. Among the pro arguments, is the demonstration that, in several studies, high-intensity training appears to induce superior improvements in aerobic fitness. Among the contra arguments to prescribe high-intensity exercise is the demonstration that prescribing a higher-intensity exercise decreases adherence and results in the completion of less exercise. Thus, a successful exercise program should be proposed at a moderate intensity and a low perceived effort because obese subjects who have low self-efficacy, poor mood status, and are not familiar with high-intensity workouts could easily drop out. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Intensity ratio measurements for density sensitive lines of highly charged Fe ions

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Safdar, E-mail: safdaruetian@gmail.com; Shimizu, Erina [Institute for Laser Science, The University of Electro-Communications (Japan); Sakaue, Hiroyuki A.; Kato, Daiji; Murakami, Izumi [National Institute for Fusion Science (Japan); Yamamoto, Norimasa [Chubu University (Japan); Hara, Hirohisa; Watanabe, Tetsuya [The Graduate University of Advanced Studies (SOKENDAI) (Japan); Nakamura, Nobuyuki, E-mail: n-nakamu@ils.uec.ac.jp [Institute for Laser Science, The University of Electro-Communications (Japan)

    2015-11-15

    Intensity ratio of density sensitive emission lines emitted from Fe ions in the extreme ultraviolet region is important for astrophysics applications. We report high-resolution intensity ratio measurements for Fe ions performed at Tokyo EBIT laboratory by employing a flat-field grazing incidence spectrometer. The experimental intensity ratios of Fe X and Fe XII are plotted as a function of electron density for different electron beam currents. The experimental results are compared with the predicted intensity ratios from the model calculations.

  12. Short-pulse high intensity laser thin foil interaction

    Science.gov (United States)

    Audebert, Patrick

    2003-10-01

    The technology of ultrashort pulse laser generation has progressed to the point that optical pulses larger than 10 J, 300 fs duration or shorter are routinely produced. Such pulses can be focused to intensities exceeding 10^18 W/cm^2. With high contrast pulses, these focused intensities can be used to heat solid matter to high temperatures with minimal hydrodynamic expansion, producing an extremely high energy-density state of matter for a short period of time. This high density, high temperature plasma can be studied by x-ray spectroscopy. We have performed experiments on thin foils of different elements under well controlled conditions at the 100 Terawatt laser at LULI to study the characteristics X-ray emission of laser heated solids. To suppress the ASE effect, the laser was frequency doubled. S-polarized light with a peak intensity of 10^19W/cm^2 was used to minimize resonance absorption. To decrease the effect of longitudinal temperature gradients very thin (800 μ) aluminum foil targets were used. We have also studied the effect of radial gradient by limiting the measured x-ray emission zone using 50μ or 100μ pinhole on target. The spectra, in the range 7-8Å, were recorded using a conical crystal spectrometer coupled to a 800 fs resolution streak camera. A Fourier Domain Interferometry (FDI) of the back of the foil was also performed providing a measurement of the hydrodynamic expansion as function of time for each shot. To simulate the experiment, we used the 1D hydrodynamic code FILM with a given set of plasma parameter (ρ, Te) as initial conditions. The X-ray emission was calculated by post processing hydrodynamic results with a collisional-radiative model which uses super-configuration average atomic data. The simulation reproduces the main features of the experimental time resolved spectrum.

  13. Extremely high-intensity laser interactions with fundamental quantum systems

    CERN Document Server

    Di Piazza, A; Hatsagortsyan, K Z; Keitel, C H

    2011-01-01

    The field of laser-matter interaction traditionally deals with the response of atoms, molecules and plasmas to an external light wave. However, the recent sustained technological progress is opening the possibility of employing intense laser radiation to prompt or substantially influence physical processes beyond atomic-physics energy scales. Available optical laser intensities exceeding $10^{22}\\;\\text{W/cm$^2$}$ can push the fundamental light-electron interaction to the extreme limit where radiation-reaction effects dominate the electron dynamics, can shed light on the structure of the quantum vacuum and can prime the creation of particles like electrons, muons and pions and the corresponding antiparticles. Also, novel sources of intense coherent high-energy photons and laser-based particle colliders can pave the way to nuclear quantum optics and can even allow for potential discovery of new particles beyond the Standard Model. These are the main topics of the present article, which is devoted to a review o...

  14. Sub-picosecond energy transfer from a highly intense THz pulse to water: a computational study based on the TIP4P/2005 model

    CERN Document Server

    Mishra, Pankaj Kr; Santra, Robin

    2016-01-01

    The dynamics of ultrafast energy transfer to water clusters and to bulk water by a highly intense, sub-cycle THz pulse of duration $\\approx$~150~fs is investigated in the context of force-field molecular dynamics simulations. We focus our attention on the mechanisms by which rotational and translational degrees of freedom of the water monomers gain energy from these sub-cycle pulses with an electric field amplitude of up to about 0.6~V/{\\AA}. It has been recently shown that pulses with these characteristics can be generated in the laboratory [PRL 112, 213901 (2014)]. Through their permanent dipole moment, water molecules are acted upon by the electric field and forced off their preferred hydrogen-bond network conformation. This immediately sets them in motion with respect to one another as energy quickly transfers to their relative center of mass displacements. We find that, in the bulk, the operation of these mechanisms is strongly dependent on the initial temperature and density of the system. In low densit...

  15. Periods of High Intensity Solar Proton Flux

    Science.gov (United States)

    Xapsos, Michael A.; Stauffer, Craig A.; Jordan, Thomas M.; Adams, James H.; Dietrich, William F.

    2012-01-01

    Analysis is presented for times during a space mission that specified solar proton flux levels are exceeded. This includes both total time and continuous time periods during missions. Results for the solar maximum and solar minimum phases of the solar cycle are presented and compared for a broad range of proton energies and shielding levels. This type of approach is more amenable to reliability analysis for spacecraft systems and instrumentation than standard statistical models.

  16. Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: an in vivo feasibility study in a transgenic mouse model of pancreatic cancer.

    Science.gov (United States)

    Chen, Hong; Hou, Gary Y; Han, Yang; Payen, Thomas; Palermo, Carmine F; Olive, Kenneth P; Konofagou, Elisa E

    2015-09-01

    Harmonic motion imaging (HMI) is a radiationforce- based elasticity imaging technique that tracks oscillatory tissue displacements induced by sinusoidal ultrasonic radiation force to assess the resulting oscillatory displacement denoting the underlying tissue stiffness. The objective of this study was to evaluate the feasibility of HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. The HMI system consisted of a focused ultrasound transducer, which generated sinusoidal radiation force to induce oscillatory tissue motion at 50 Hz, and a diagnostic ultrasound transducer, which detected the axial tissue displacements based on acquired radio-frequency signals using a 1-D cross-correlation algorithm. For pancreatic tumor detection, HMI images were generated for pancreatic tumors in transgenic mice and normal pancreases in wild-type mice. The obtained HMI images showed a high contrast between normal and malignant pancreases with an average peak-to-peak HMI displacement ratio of 3.2. Histological analysis showed that no tissue damage was associated with HMI when it was used for the sole purpose of elasticity imaging. For pancreatic tumor ablation monitoring, the focused ultrasound transducer was operated at a higher acoustic power and longer pulse length than that used in tumor detection to simultaneously induce HIFU thermal ablation and oscillatory tissue displacements, allowing HMI monitoring without interrupting tumor ablation. HMI monitoring of HIFU ablation found significant decreases in the peak-to-peak HMI displacements before and after HIFU ablation with a reduction rate ranging from 15.8% to 57.0%. The formation of thermal lesions after HIFU exposure was confirmed by histological analysis. This study demonstrated the feasibility of HMI in abdominal tumor detection and HIFU ablation monitoring.

  17. Simplified shielding calculation system for high-intensity proton accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Masumura, Tomomi; Nakashima, Hiroshi; Nakane, Yoshihiro; Sasamoto, Nobuo [Center for Neutron Science, Tokai Research Establishment, Japan Atomic Energy Research Institute, Tokai, Ibaraki (Japan)

    2000-06-01

    A simplified shielding calculation system is developed for applying conceptual shielding design of facilities in the joint project for high-intensity proton accelerators. The system is composed of neutron transmission calculation part for bulk shielding using simplified formulas: Moyer model and Tesch's formula, and neutron skyshine calculation part using an empirical formula: Stapleton's formula. The system is made with the Microsoft Excel software for user's convenience. This report provides a manual for the system as well as calculation conditions used in the calculation such as Moyer model's parameters. In this report preliminary results based on data at December 8, 1999, are also shown as an example. (author)

  18. SALIVARY CORTISOL RESPONSES AND PERCEIVED EXERTION DURING HIGH INTENSITY AND LOW INTENSITY BOUTS OF RESISTANCE EXERCISE

    Directory of Open Access Journals (Sweden)

    Alison D. Egan

    2004-03-01

    Full Text Available The purpose of this study was to measure the salivary cortisol response to different intensities of resistance exercise. In addition, we wanted to determine the reliability of the session rating of perceived exertion (RPE scale to monitor resistance exercise intensity. Subjects (8 men, 9 women completed 2 trials of acute resistance training bouts in a counterbalanced design. The high intensity resistance exercise protocol consisted of six, ten-repetition sets using 75% of one repetition maximum (RM on a Smith machine squat and bench press exercise (12 sets total. The low intensity resistance exercise protocol consisted of three, ten-repetition sets at 30% of 1RM of the same exercises as the high intensity protocol. Both exercise bouts were performed with 2 minutes of rest between each exercise and sessions were repeated to test reliability of the measures. The order of the exercise bouts was randomized with least 72 hours between each session. Saliva samples were obtained immediately before, immediately after and 30 mins following each resistance exercise bout. RPE measures were obtained using Borg's CR-10 scale following each set. Also, the session RPE for the entire exercise session was obtained 30 minutes following completion of the session. There was a significant 97% increase in the level of salivary cortisol immediately following the high intensity exercise session (P<0.05. There was also a significant difference in salivary cortisol of 145% between the low intensity and high intensity exercise session immediately post-exercise (P<0.05. The low intensity exercise did not result in any significant changes in cortisol levels. There was also a significant difference between the session RPE values for the different intensity levels (high intensity 7.1 vs. low intensity 1.9 (P<0.05. The intraclass correlation coefficient for the session RPE measure was 0.95. It was concluded that the session RPE method is a valid and reliable method of

  19. Feasibility Study on MR-Guided High-Intensity Focused Ultrasound Ablation of Sciatic Nerve in a Swine Model: Preliminary Results

    Energy Technology Data Exchange (ETDEWEB)

    Kaye, Elena A., E-mail: kayee@mskcc.org [Memorial Sloan Kettering Cancer Center, Department of Medical Physics (United States); Gutta, Narendra Babu, E-mail: gnbabu.aiims@gmail.com [Memorial Sloan Kettering Cancer Center, Department of Radiology (United States); Monette, Sebastien, E-mail: monettes@mskcc.org [The Rockefeller University, Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College (United States); Gulati, Amitabh, E-mail: gulatia@mskcc.org; Loh, Jeffrey, E-mail: jeffreyloh@gmail.com [Memorial Sloan Kettering Cancer Center, Department of Anesthesiology-Critical Care (United States); Srimathveeravalli, Govindarajan, E-mail: srimaths@mskcc.org [Memorial Sloan Kettering Cancer Center, Department of Radiology (United States); Ezell, Paula C., E-mail: paula.ezell@intusurg.com [The Rockefeller University, Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College (United States); Erinjeri, Joseph P., E-mail: erinjerj@mskcc.org; Solomon, Stephen B., E-mail: solomons@mskcc.org; Maybody, Majid, E-mail: maybodym@mskcc.org [Memorial Sloan Kettering Cancer Center, Department of Radiology (United States)

    2015-08-15

    IntroductionSpastic patients often seek neurolysis, the permanent destruction of the sciatic nerve, for better pain management. MRI-guided high-intensity focused ultrasound (MRgHIFU) may serve as a noninvasive alternative to the prevailing, more intrusive techniques. This in vivo acute study is aimed at performing sciatic nerve neurolysis using a clinical MRgHIFU system.MethodsThe HIFU ablation of sciatic nerves was performed in swine (n = 5) using a HIFU system integrated with a 3 T MRI scanner. Acute lesions were confirmed using T1-weighted contrast-enhanced (CE) MRI and histopathology using hematoxylin and eosin staining. The animals were euthanized immediately following post-ablation imaging.ResultsReddening and mild thickening of the nerve and pallor of the adjacent muscle were seen in all animals. The HIFU-treated sections of the nerves displayed nuclear pyknosis of Schwann cells, vascular hyperemia, perineural edema, hyalinization of the collagenous stroma of the nerve, myelin sheet swelling, and loss of axons. Ablations were visible on CE MRI. Non-perfused volume of the lesions (5.8–64.6 cc) linearly correlated with estimated lethal thermal dose volume (4.7–34.2 cc). Skin burn adjacent to the largest ablated zone was observed in the first animal. Bilateral treatment time ranged from 55 to 138 min, and preparation time required 2 h on average.ConclusionThe acute pilot study in swine demonstrated the feasibility of a noninvasive neurolysis of the sciatic nerve using a clinical MRgHIFU system. Results revealed that acute HIFU nerve lesions were detectable on CE MRI, gross pathology, and histology.

  20. High Intensity Accelerator and Neutron Source in China

    Science.gov (United States)

    Guan, Xialing; Wei, J.; Loong, Chun

    2011-06-01

    High intensity Accelerator is being studied all over world for numerous applications, which includes the waste transmutation, spallation neutron source and material irradiation facilities. The R/D activities of the technology of High intensity accelerator are also developed in China for some year, and have some good facilities around China. This paper will reports the status of some high intensity accelerators and neutron source in China, which including ADS/RFQ; CARR; CSNS; PKUNIFTY & CPHS. This paper will emphatically report the Compact Pulsed Hadron Source (CPHS) led by the Department of Engineering Physics of Tsinghua University in Beijing, China.

  1. ELECTRON CLOUD EFFECTS IN HIGH INTENSITY PROTON ACCELERATORS.

    Energy Technology Data Exchange (ETDEWEB)

    WEI,J.; MACEK,R.J.

    2002-04-14

    One of the primary concerns in the design and operation of high-intensity proton synchrotrons and accumulators is the electron cloud and associated beam loss and instabilities. Electron-cloud effects are observed at high-intensity proton machines like the Los Alamos National Laboratory's PSR and CERN's SPS, and investigated experimentally and theoretically. In the design of next-generation high-intensity proton accelerators like the Spallation Neutron Source ring, emphasis is made in minimizing electron production and in enhancing Landau damping. This paper reviews the present understanding of the electron-cloud effects and presents mitigation measures.

  2. Repeated high-intensity exercise in professional rugby union.

    Science.gov (United States)

    Austin, Damien; Gabbett, Tim; Jenkins, David

    2011-07-01

    The aim of the present study was to describe the frequency, duration, and nature of repeated high-intensity exercise in Super 14 rugby union. Time-motion analysis was used during seven competition matches over the 2008 and 2009 Super 14 seasons; five players from each of four positional groups (front row forwards, back row forwards, inside backs, and outside backs) were assessed (20 players in total). A repeated high-intensity exercise bout was considered to involve three or more sprints, and/or tackles and/or scrum/ruck/maul activities within 21 s during the same passage of play. The range of repeated high-intensity exercise bouts for each group in a match was as follows: 11-18 for front row forwards, 11-21 for back row forwards, 13-18 for inside backs, and 2-11 for outside backs. The durations of the most intense repeated high-intensity exercise bouts for each position ranged from 53 s to 165 s and the minimum recovery periods between repeated high-intensity exercise bouts ranged from 25 s for the back row forwards to 64 s for the front row forwards. The present results show that repeated high-intensity exercise bouts vary in duration and activities relative to position but all players in a game will average at least 10 changes in activity in the most demanding bouts and complete at least one tackle and two sprints. The most intense periods of activity are likely to last as long as 120 s and as little as 25 s recovery may separate consecutive repeated high-intensity exercise bouts. The present findings can be used by coaches to prepare their players for the most demanding passages of play likely to be experienced in elite rugby union.

  3. High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise.

    Science.gov (United States)

    Saucedo Marquez, Cinthia Maria; Vanaudenaerde, Bart; Troosters, Thierry; Wenderoth, Nicole

    2015-12-15

    Exercise can have a positive effect on the brain by activating brain-derived neurotrophic factor (BDNF)-related processes. In healthy humans there appears to be a linear relationship between exercise intensity and the positive short-term effect of acute exercise on BDNF levels (i.e., the highest BDNF levels are reported after high-intensity exercise protocols). Here we performed two experiments to test the effectiveness of two high-intensity exercise protocols, both known to improve cardiovascular health, to determine whether they have a similar efficacy in affecting BDNF levels. Participants performed a continuous exercise (CON) protocol at 70% of maximal work rate and a high-intensity interval-training (HIT) protocol at 90% of maximal work rate for periods of 1 min alternating with 1 min of rest (both protocols lasted 20 min). We observed similar BDNF kinetics in both protocols, with maximal BDNF concentrations being reached toward the end of training (experiment 1). We then showed that both exercise protocols significantly increase BDNF levels compared with a rest condition (CON P = 0.04; HIT P exercise are slightly more effective than continuous high-intensity exercise for elevating serum BDNF. Additionally, 73% of the participants preferred the HIT protocol (P = 0.02). Therefore, we suggest that the HIT protocol might represent an effective and preferred intervention for elevating BDNF levels and potentially promoting brain health.

  4. High Intensity Tactical Power Sources for the 1990 Army.

    Science.gov (United States)

    conceptual or physical study which may become feasible as high intensity power sources . These considerations include present state of the art of...requirements, energy and power output capabilities, and fixed costs. From these tables, it may be seen that a variety of electrical power sources would be...required to satisfy diverse requirements, but an attempt is made to categorize possible high intensity power sources into their areas of optimum

  5. Effect of high intensity ultrasound on the allergenicity of shrimp

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The tropomyosin fraction of shrimp proteins is potentially responsible for allergic reaction in individuals with genetic predisposition to allergy. However, there are no efficient and safe methods to reduce its allergenicity. High intensity ultrasound is known to change the structure of proteins. This study is aimed at assessing high intensity ultrasound's effect on the allergenicity of shrimp allergen. Shrimp and purified shrimp allergen were treated with high intensity ultrasound for 30~180 min. Extracts of treated samples were analyzed by enzyme-linked immunosorbent assay (ELISA) with pool serum of shrimp allergy patients and polyclonal anti-allergen antibodies and by immunoblotting after polyacrylamide gel electrophoresis. Shrimp treated with high intensity ultrasound showed a decrease in allergenicity measured with ELISA. A linear relationship between the immune response induced by treated shrimp allergen and the applied treatment time was observed. The decrease in allergenicity was confirmed by immunoblot assays with shrimp allergic patients serum. Allergenicity of shrimp allergen extracted from treated shrimp was higher than that of purified shrimp allergen with the same treatment time. Gel-filtration HPLC was applied for analysis of shrimp allergen after treatment with high intensity ultrasound. Some fractions were appeared with increasing treatment time. The results suggested that high intensity ultrasound could be used to reduce the allergenicity of shrimp.

  6. High performance computation on beam dynamics problems in high intensity compact cyclotrons

    Institute of Scientific and Technical Information of China (English)

    ADELMANN; Andreas

    2011-01-01

    This paper presents the research progress in the beam dynamics problems for future high intensity compact cyclotrons by utilizing the state-of-the-art high performance computation technology. A "Start-to-Stop" model, which includes both the interaction of the internal particles of a single bunch and the mutual interaction of neighboring multiple bunches in the radial direction, is established for compact cyclotrons with multi-turn extraction. This model is then implemented in OPAL-CYCL, which is a 3D object-oriented parallel code for large scale particle simulations in cyclotrons. In addition, to meet the running requirement of parallel computation, we have constructed a small scale HPC cluster system and tested its performance. Finally, the high intensity beam dynamics problems in the 100 MeV compact cyclotron, which is being constructed at CIAE, are studied using this code and some conclusions are drawn.

  7. An Empirical Model of FUV Auroral Intensity

    Science.gov (United States)

    1992-02-25

    intensity [Feldstein and Starkov , 1970; Sandford, 1968; Shepherd, 1979] is the large field-of-view of the space-borne imaging instrument, the automatic...BEAR, Ultraviolet Technology, Proc. SPIE, 1988. Feldstein, Y. I., and Starkov , G. V., The auroral oval and the boundary of closed field lines of

  8. Blood coagulation using High Intensity Focused Ultrasound (HIFU)

    Science.gov (United States)

    Nguyen, Phuc V.; Oh, Junghwan; Kang, Hyun Wook

    2014-03-01

    High Intensity Focused Ultrasound (HIFU) technology provides a feasible method of achieving thermal coagulation during surgical procedures. One of the potential clinical benefits of HIFU can induce immediate hemostasis without suturing. The objective of this study was to investigate the efficiency of a HIFU system for blood coagulation on severe vascular injury. ngHIFU treatment was implemented immediately after bleeding in artery. The ultrasound probe was made of piezoelectric material, generating a central frequency of 2.0 MHz as well as an ellipsoidal focal spot of 2 mm in lateral dimension and 10 mm in axial dimension. Acoustic coagulation was employed on a perfused chicken artery model in vitro. A surgical incision (1 to 2 mm long) was made with a scapel on the arterial wall, and heparinized autologous blood was made to leak out from the incision with a syringe pump. A total of 5 femoral artery incisions was treated with the HIFU beam. The intensity of 4500 W/cm2 at the focus was applied for all treatments. Complete hemostasis was achieved in all treatments, along with the treatment times of 25 to 50 seconds. The estimated intraoperative blood loss was from 2 to 5 mL. The proposed HIFU system may provide an effective method for immediate blood coagulation for arteries and veins in clinical applications.

  9. Linguistics Computation, Automatic Model Generation, and Intensions

    CERN Document Server

    Nourani, C F

    1994-01-01

    Techniques are presented for defining models of computational linguistics theories. The methods of generalized diagrams that were developed by this author for modeling artificial intelligence planning and reasoning are shown to be applicable to models of computation of linguistics theories. It is shown that for extensional and intensional interpretations, models can be generated automatically which assign meaning to computations of linguistics theories for natural languages. Keywords: Computational Linguistics, Reasoning Models, G-diagrams For Models, Dynamic Model Implementation, Linguistics and Logics For Artificial Intelligence

  10. Additive Intensity Regression Models in Corporate Default Analysis

    DEFF Research Database (Denmark)

    Lando, David; Medhat, Mamdouh; Nielsen, Mads Stenbo

    2013-01-01

    We consider additive intensity (Aalen) models as an alternative to the multiplicative intensity (Cox) models for analyzing the default risk of a sample of rated, nonfinancial U.S. firms. The setting allows for estimating and testing the significance of time-varying effects. We use a variety of mo...

  11. Review of High-intensity Interval Training in Cardiac Rehabilitation.

    Science.gov (United States)

    Ito, Shigenori; Mizoguchi, Tatsuya; Saeki, Tomoaki

    2016-01-01

    For the secondary prevention of cardiovascular disease, comprehensive cardiac rehabilitation is required. This involves optimal medical therapy, education on nutrition and exercise therapy, and smoking cessation. Of these, efficient exercise therapy is a key factor. A highly effective training protocol is therefore warranted, which requires a high rate of compliance. Although moderate-intensity continuous training has been the main training regimen recommended in cardiac rehabilitation guidelines, high-intensity interval training has been reported to be more effective in the clinical and experimental setting from the standpoint of peak oxygen uptake and central and peripheral adaptations. In this review, we illustrate the scientific evidence for high-intensity interval training. We then verify this evidence and discuss its significance and the remaining issues.

  12. The generation of high-quality, intense ion beams by ultra-intense lasers

    CERN Document Server

    Roth, M; Audebert, Patrick; Blazevic, A; Brambrink, E; Cowan, T E; Fuchs, J; Gauthier, J C; Geissel, M; Hegelich, M; Karsch, S; Meyer-Ter-Vehn, J; Ruhl, H; Schlegel, T; Stephens, R B

    2002-01-01

    Intense beams of protons and heavy ions have been observed in ultra-intense laser-solid interaction experiments. Thereby, a considerable fraction of the laser energy is transferred to collimated beams of energetic ions (e.g. up to 50 MeV protons; 100 MeV fluorine), which makes these beams highly interesting for various applications. Experimental results indicate a very short-pulse duration and an excellent beam quality, leading to beam intensities in the TW range. To characterize the beam quality and its dependence on laser parameters and target conditions we performed experiments using the 100 TW laser system at Laboratoire pour l'Utilisation des Lasers Intenses at the Ecole Polytechnique, France, with focused intensities exceeding 10 sup 1 sup 9 W cm sup - sup 2. We found a strong dependence on the target rear surface conditions allowing to tailor the ion beam by an appropriate target design. We also succeeded in the generation of heavy ion beams by suppressing the proton amount at the target surface. We wi...

  13. High-intensity light-emitting diode vs fluorescent tubes for intensive phototherapy in neonates.

    Science.gov (United States)

    Sherbiny, Hanan S; Youssef, Doaa M; Sherbini, Ahmad S; El-Behedy, Rabab; Sherief, Laila M

    2016-05-01

    Special blue fluorescent tubes are recommended by the American Academy of Pediatrics (AAP) as the most effective light source for lowering serum bilirubin. A high-intensity light-emitting diode ('super LED') could render intensive phototherapy more effective than the above conventional methods. This study compared the efficacy and safety of a high-intensity light-emitting diode bed vs conventional intensive phototherapy with triple fluorescent tube units as a rescue treatment for severe unconjugated neonatal hyperbilirubinaemia. This was a randomised, prospective trial. Two hundred jaundiced neonates ≥ 35 weeks gestation who met the criteria for intensive phototherapy as per AAP guidelines were randomly assigned to be treated either with triple fluorescent tube units (group 1, n = 100) or a super LED bed (group 2, n = 100). The outcome was the avoidance of exchange transfusion by successful control of hyperbilirubinaemia. Statistically significant higher success rates of intensive phototherapy were achieved among neonates treated with super LED (group 2) than in those treated conventionally (group 1) (87% vs 64%, P = 0.003). Significantly higher 'bilirubin decline' rates were reported in both haemolytic and non-haemolytic subgroups treated with the super LED bed compared with a similar sub-population in the conventionally treated group. Comparable numbers of neonates in both groups developed rebound jaundice (8% vs 10% of groups 1 and 2, respectively). Side-effects were mild in both groups, but higher rates of hyperthermia (12% vs 0%, P = 0.03), dehydration (8% vs 2%, P = 0.26) and skin rash (39% vs 1%, P = 0.002) were reported in the fluorescent tubes-treated group compared with the LED group. Super LED is a safe rescue treatment for severe neonatal hyperbilirubinaemia, and its implementation may reduce the need for exchange transfusion.

  14. Simulation study of the high intensity S-Band photoinjector

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Xiongwei; Nakajima, Kazuhisa [High Energy Accelerator Research Organization, Tsukuba, Ibaraki (Japan)

    2001-10-01

    In this paper, we report the results of simulation study of the high intensity S-Band photoinjector. The aim of the simulation study is to transport high bunch charge with low emittance evolution. The simulation result shows that 7nC bunch with rms emittance 22.3 {pi} mm mrad can be outputted at the exit of photoinjector. (author)

  15. Acute plasma volume change with high-intensity sprint exercise.

    Science.gov (United States)

    Bloomer, Richard J; Farney, Tyler M

    2013-10-01

    When exercise is of long duration or of moderate to high intensity, a decrease in plasma volume can be observed. This has been noted for both aerobic and resistance exercise, but few data are available with regard to high-intensity sprint exercise. We measured plasma volume before and after 3 different bouts of acute exercise, of varying intensity, and/or duration. On different days, men (n = 12; 21-35 years) performed aerobic cycle exercise (60 minutes at 70% heart rate reserve) and 2 different bouts of cycle sprints (five 60-second sprints at 100% maximum wattage obtained during graded exercise testing (GXT) and ten 15-second sprints at 200% maximum wattage obtained during GXT). Blood was collected before and 0, 30, and 60 minutes postexercise and analyzed for hematocrit and hemoglobin and plasma volume was calculated. Plasma volume decreased significantly for all exercise bouts (p sprint bouts (∼19%) compared with aerobic exercise bouts (∼11%). By 30 minutes postexercise, plasma volume approached pre-exercise values. We conclude that acute bouts of exercise, in particular high-intensity sprint exercise, significantly decrease plasma volume during the immediate postexercise period. It is unknown what, if any negative implications these transient changes may have on exercise performance. Strength and conditioning professionals may aim to rehydrate athletes appropriately after high-intensity exercise bouts.

  16. Generation of Intense High-Order Vortex Harmonics

    CERN Document Server

    Zhang, Xiaomei; Shi, Yin; Wang, Xiaofeng; Zhang, Lingang; Wang, Wenpeng; Xu, Jiancai; Yi, Longqiong; Xu, Zhizhan

    2014-01-01

    This paper presents the method for the first time to generate intense high-order optical vortices that carry orbital angular momentum in the extreme ultraviolet region. In three-dimensional particle-in-cell simulation, both the reflected and transmitted light beams include high-order harmonics of the Laguerre-Gaussian (LG) mode when a linearly polarized LG laser pulse impinges on a solid foil. The mode of the generated LG harmonic scales with its order, in good agreement with our theoretical analysis. The intensity of the generated high-order vortex harmonics is close to the relativistic region, and the pulse duration can be in attosecond scale. The obtained intense vortex beam possesses the combined properties of fine transversal structure due to the high-order mode and the fine longitudinal structure due to the short wavelength of the high-order harmonics. Thus, the obtained intense vortex beam may have extraordinarily promising applications for high-capacity quantum information and for high-resolution dete...

  17. Application of fluent to the 3D modeling of a river basin, to study hydraulics phenomena in presence of high intensity rain events

    Energy Technology Data Exchange (ETDEWEB)

    Martini, G.; Pais, V.A. [ENEA, Divisione Caratterizzazione dell' Ambiente e del Territorio, Centro Ricerche, Frascati, Rome (Italy)

    2000-07-01

    This report presents the preliminary studies carried out with Fluent (a commercial multi-purpose fluid dynamics code) to describe a 3D river basin hydrological evolution when intense rain events take place. The results for basins with slope less than 60{sup 0} are encouraging, evidencing the evolution of a flood wave that fills the riverbed and overtakes the river embankments, and providing information about the pressure and the velocity fields. Either for more sharpens or for larger basins, some difficulties appear that could be solved adopting a more careful re-elaboration of the meshing process or moving to a more powerful computer, respectively. [Italian] Il presente lavoro riferisce gli studi preliminari condotti con FLUENT (un codice commerciale di simulazione fluidodinamica generale) per la descrizione della evoluzione idrologica di un bacino 3D quando si manifestano eventi piovosi estremi. I risultati per bacini con pendenze inferiori a 60{sup 0} sono incoraggianti, evidenziando la evoluzione di una onda di piena che supera gli argini dell'alveo e fornendo informazioni sui campi di pressione e velocita'. Sia per bacini con pendenze piu' spinte sia per bacini piu' estesi, si sono presentate alcune difficolta' che potrebbero essere risolte attraverso una rielaborazione piu' accurata della griglia di simulazione o l'uso di un computer sufficientemente potente.

  18. High Intensity Particle Physics at PW-class laser facilities

    Science.gov (United States)

    Bulanov, Stepan; Schroeder, Carl; Esarey, Eric; Esirkepov, Timur; Kando, Masaki; Rosanov, Nikolay; Korn, Georg; Bulanov, Sergey V.; Leemans, Wim P.

    2015-11-01

    The processes typical for high intensity particle physics, i.e., the interactions of charged particles with strong electromagnetic fields, have attracted considerable interest recently. Some of these processes, previously believed to be of theoretical interest only, are now becoming experimentally accessible. High intensity electromagnetic (EM) fields significantly modify the interactions of particles and EM fields, giving rise to the phenomena that are not encountered either in classical or perturbative quantum theory of these interactions. One of such phenomena is the radiation reaction, which radically influences the electron motion in an electromagnetic standing wave formed by two super-intense counter-propagating laser pulses. Depending on the laser intensity and wavelength, either classical or quantum mode of radiation reaction prevail, or both are strong. When radiation reaction dominates, electron motion evolves to limit cycles and strange attractors. This creates a new framework for high energy physics experiments on an interaction of energetic charged particle beams and colliding super-intense laser pulses. Work supported by U.S. DOE under Contract No. DE-AC02-05CH11231.

  19. Light-intensity and high-intensity interval training improve cardiometabolic health in rats.

    Science.gov (United States)

    Batacan, Romeo B; Duncan, Mitch J; Dalbo, Vincent J; Connolly, Kylie J; Fenning, Andrew S

    2016-09-01

    Physical activity has the potential to reduce cardiometabolic risk factors but evaluation of different intensities of physical activity and the mechanisms behind their health effects still need to be fully established. This study examined the effects of sedentary behaviour, light-intensity training, and high-intensity interval training on biometric indices, glucose and lipid metabolism, inflammatory and oxidative stress markers, and vascular and cardiac function in adult rats. Rats (12 weeks old) were randomly assigned to 1 of 4 groups: control (CTL; no exercise), sedentary (SED; no exercise and housed in small cages to reduce activity), light-intensity trained (LIT; four 30-min exercise bouts/day at 8 m/min separated by 2-h rest period, 5 days/week), and high-intensity interval trained (HIIT, four 2.5-min work bouts/day at 50 m/min separated by 3-min rest periods, 5 days/week). After 12 weeks of intervention, SED had greater visceral fat accumulation (p < 0.01) and slower cardiac conduction (p = 0.04) compared with the CTL group. LIT and HIIT demonstrated beneficial changes in body weight, visceral and epididymal fat weight, glucose regulation, low-density lipoprotein cholesterol, total cholesterol, and mesenteric vessel contractile response compared with the CTL group (p < 0.05). LIT had significant improvements in insulin sensitivity and cardiac conduction compared with the CTL and SED groups whilst HIIT had significant improvements in systolic blood pressure and endothelium-independent vasodilation to aorta and mesenteric artery compared with the CTL group (p < 0.05). LIT and HIIT induce health benefits by improving traditional cardiometabolic risk factors. LIT improves cardiac health while HIIT promotes improvements in vascular health.

  20. Thomson scattering in high-intensity chirped laser pulses

    Energy Technology Data Exchange (ETDEWEB)

    Holkundkar, Amol R., E-mail: amol.holkundkar@pilani.bits-pilani.ac.in [Department of Physics, Birla Institute of Technology and Science, Pilani, Rajasthan 333031 (India); Harvey, Chris, E-mail: christopher.harvey@chalmers.se; Marklund, Mattias, E-mail: mattias.marklund@chalmers.se [Department of Applied Physics, Chalmers University of Technology, SE-41296 Gothenburg (Sweden)

    2015-10-15

    We consider the Thomson scattering of an electron in an ultra-intense laser pulse. It is well known that at high laser intensities, the frequency and brilliance of the emitted radiation will be greatly reduced due to the electron losing energy before it reaches the peak field. In this work, we investigate the use of a small frequency chirp in the laser pulse in order to mitigate this effect of radiation reaction. It is found that the introduction of a negative chirp means the electron enters a high frequency region of the field while it still has a large proportion of its original energy. This results in a significant enhancement of the frequency and intensity of the emitted radiation as compared to the case without chirping.

  1. Plasma-based polarization modulator for high-intensity lasers

    Science.gov (United States)

    Chen, Zi-Yu; Pukhov, Alexander

    2016-12-01

    Manipulation of laser pulses at high intensities is an important yet challenging issue. New types of plasma-based optical devices are promising alternatives to achieve this goal. Here we propose to modulate the polarization state of intense lasers based on oblique reflection from solid-plasma surfaces. A new analytical description is presented considering the plasma as an uniaxial medium that causes birefringence effect. Particle-in-cell simulation results numerically demonstrate that such a scheme can provide a tunable polarization control of the laser pulses even in the relativistic regime. The results are thus relevant for the design of compact, easy to use, and versatile polarization modulators for high-intensity laser pulses.

  2. Self-trapping of intensities changing under SHG and SWG for high intensive femtosecond laser pulse

    Science.gov (United States)

    Trofimov, Vyacheslav A.; Kharitonov, Dmitry M.; Fedotov, Mikhail V.

    2017-05-01

    SHG and SFG (SWG) and THG are used widely in many practical applications such as a substance diagnostics, and imaging of various physical, chemical and biological processes as well as for laser radiation frequency conversion. One of very interesting phenomena under the frequency conversion takes place if a basic wave incident intensity is enough high: a synchronic mode of the laser pulse intensities changing along a propagation coordinate appears under certain conditions. First of all, we investigate this phenomenon using the frame-work of long pulse duration approximation and plane wave approximation without applying the basic wave energy non-depletion approximation. Applying an original approach we derive the solution of Schr¨odinger equations describing the THG via a SHG process and summary frequency wave generation (SFG) process for femtosecond pulses. Among many modes of the frequency conversion process under consideration we found out analytically the mode corresponding to synchronous intensities changing for the interacting waves. We derive conditions of such mode realization in dependence of the problem parameters. After that we verify our analytical consideration using a computer simulation of the problem on the base of the corresponding Schr¨odinger equations. Computer simulation shown also a new phenomenon at three-wave interaction: interacting wave intensities changing with two (or more) oscillation periods.

  3. High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia

    Directory of Open Access Journals (Sweden)

    Kenneth N. Grisé

    2016-01-01

    Full Text Available Indices of cardiovascular autonomic neuropathy (CAN in experimental models of Type 1 diabetes mellitus (T1DM are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV autonomic function more reflective of clinical results and if exercise training could prevent those deficits. Sixty-four rats were divided into four groups: sedentary control (C, sedentary T1DM (D, control exercise (CX, or T1DM exercise (DX. Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9–17 mM through insulin supplementation. Exercise training consisted of daily treadmill running for 10 weeks. Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY, and decreased intrinsic heart rate. In contrast, DX differed from D in all measures of CAN (except NPY, including heart rate variability. These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM.

  4. Mechanism and computational model for Lyman-{alpha}-radiation generation by high-intensity-laser four-wave mixing in Kr-Ar gas

    Energy Technology Data Exchange (ETDEWEB)

    Louchev, Oleg A.; Saito, Norihito; Wada, Satoshi [Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198 (Japan); Bakule, Pavel [STFC, ISIS Facility, Rutherford Appleton Laboratory, Chilton, Oxfordshire OX11 0QX (United Kingdom); Yokoyama, Koji [Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198 (Japan); Advanced Meson Science Laboratory, RIKEN Nishina Center, RIKEN, Wako, Saitama 351-0198 (Japan); Ishida, Katsuhiko; Iwasaki, Masahiko [Advanced Meson Science Laboratory, RIKEN Nishina Center, RIKEN, Wako, Saitama 351-0198 (Japan)

    2011-09-15

    We present a theoretical model combined with a computational study of a laser four-wave mixing process under optical discharge in which the non-steady-state four-wave amplitude equations are integrated with the kinetic equations of initial optical discharge and electron avalanche ionization in Kr-Ar gas. The model is validated by earlier experimental data showing strong inhibition of the generation of pulsed, tunable Lyman-{alpha} (Ly-{alpha}) radiation when using sum-difference frequency mixing of 212.6 nm and tunable infrared radiation (820-850 nm). The rigorous computational approach to the problem reveals the possibility and mechanism of strong auto-oscillations in sum-difference resonant Ly-{alpha} generation due to the combined effect of (i) 212.6-nm (2+1)-photon ionization producing initial electrons, followed by (ii) the electron avalanche dominated by 843-nm radiation, and (iii) the final breakdown of the phase matching condition. The model shows that the final efficiency of Ly-{alpha} radiation generation can achieve a value of {approx}5x10{sup -4} which is restricted by the total combined absorption of the fundamental and generated radiation.

  5. Mechanism and computational model for Lyman-α-radiation generation by high-intensity-laser four-wave mixing in Kr-Ar gas

    Science.gov (United States)

    Louchev, Oleg A.; Bakule, Pavel; Saito, Norihito; Wada, Satoshi; Yokoyama, Koji; Ishida, Katsuhiko; Iwasaki, Masahiko

    2011-09-01

    We present a theoretical model combined with a computational study of a laser four-wave mixing process under optical discharge in which the non-steady-state four-wave amplitude equations are integrated with the kinetic equations of initial optical discharge and electron avalanche ionization in Kr-Ar gas. The model is validated by earlier experimental data showing strong inhibition of the generation of pulsed, tunable Lyman-α (Ly-α) radiation when using sum-difference frequency mixing of 212.6 nm and tunable infrared radiation (820-850 nm). The rigorous computational approach to the problem reveals the possibility and mechanism of strong auto-oscillations in sum-difference resonant Ly-α generation due to the combined effect of (i) 212.6-nm (2+1)-photon ionization producing initial electrons, followed by (ii) the electron avalanche dominated by 843-nm radiation, and (iii) the final breakdown of the phase matching condition. The model shows that the final efficiency of Ly-α radiation generation can achieve a value of ˜5×10-4 which is restricted by the total combined absorption of the fundamental and generated radiation.

  6. Personalised modelling of facial action unit intensity

    NARCIS (Netherlands)

    Yang, Shuang; Rudovic, Ognjen; Pavlovic, Vladimir; Pantic, Maja

    2014-01-01

    Facial expressions depend greatly on facial morphology and expressiveness of the observed person. Recent studies have shown great improvement of the personalized over non-personalized models in variety of facial expression related tasks, such as face and emotion recognition. However, in the context

  7. Some Intensive and Extensive Quantities in High-Energy Collisions

    CERN Document Server

    Tawfik, A

    2013-01-01

    We review the evolution of some statistical and thermodynamical quantities measured in difference sizes of high-energy collisions at different energies. We differentiate between intensive and extensive quantities and discuss the importance of their distinguishability in characterizing possible critical phenomena of nuclear collisions at various energies with different initial conditions.

  8. High-Intensity Interval Training for Improving Postprandial Hyperglycemia

    Science.gov (United States)

    Little, Jonathan P.; Francois, Monique E.

    2014-01-01

    High-intensity interval training (HIIT) has garnered attention in recent years as a time-efficient exercise option for improving cardiovascular and metabolic health. New research demonstrates that HIIT may be particularly effective for improving postprandial hyperglycemia in individuals with, or at risk for, type 2 diabetes (T2D). These findings…

  9. Nonlinear Behavior in High-Intensity Discharge Lamps

    CERN Document Server

    Baumann, Bernd; Wolff, Marcus; Manders, Freddy; Suijker, Jos

    2015-01-01

    The light flicker problem of high intensity discharge lamps is studied numerically and experimentally. It is shown that in some respects the systems behaves very similar to the forced Duffing oscillator with a softening spring. In particular, the jump phenomenon and hysteresis are observed in the simulations and in the experiments.

  10. Nonlinear behavior in high-intensity discharge lamps

    Science.gov (United States)

    Baumann, Bernd; Schwieger, Joerg; Wolff, Marcus; Manders, Freddy; Suijker, Jos

    2016-06-01

    The light flicker problem of high intensity discharge lamps is studied numerically and experimentally. It is shown that in some respects the systems behave very similar to the forced Duffing oscillator with a softening spring. In particular, the jump phenomenon and hysteresis are observed in the simulations and in the experiments.

  11. Parallel Beam Dynamics Code Development for High Intensity Cyclotron

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>1 Parallel PIC algorithm Self field solver is the key part of a high intensity beam dynamic PIC code which usually adopts the P-M (Particle-Mesh) method to solve the space charge. The P-M method is composed of four major

  12. Annotated bibliography on high-intensity linear accelerators. [240 citations

    Energy Technology Data Exchange (ETDEWEB)

    Jameson, R.A.; Roybal, E.U.

    1978-01-01

    A technical bibliography covering subjects important to the design of high-intensity beam transport systems and linear accelerators is presented. Space charge and emittance growth are stressed. Subject and author concordances provide cross-reference to detailed citations, which include an abstract and notes on the material. The bibliography resides in a computer database that can be searched for key words and phrases.

  13. Intense neutron source: high-voltage power supply specifications

    Energy Technology Data Exchange (ETDEWEB)

    Riedel, A.A.

    1980-08-01

    This report explains the need for and sets forth the electrical, mechanical and safety specifications for a high-voltage power supply to be used with the intense neutron source. It contains sufficient information for a supplier to bid on such a power supply.

  14. Reuse Recycler: High Intensity Proton Stacking at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Adamson, P. [Fermilab

    2016-07-17

    After a successful career as an antiproton storage and cooling ring, Recycler has been converted to a high intensity proton stacker for the Main Injector. We discuss the commissioning and operation of the Recycler in this new role, and the progress towards the 700 kW design goal.

  15. Production of High-Intensity, Highly Charged Ions

    CERN Document Server

    Gammino, S

    2013-01-01

    In the past three decades, the development of nuclear physics facilities for fundamental and applied science purposes has required an increasing current of multicharged ion beams. Multiple ionization implies the formation of dense and energetic plasmas, which, in turn, requires specific plasma trapping configurations. Two types of ion source have been able to produce very high charge states in a reliable and reproducible way: electron beam ion sources (EBIS) and electron cyclotron resonance ion sources (ECRIS). Multiple ionization is also obtained in laser-generated plasmas (laser ion sources (LIS)), where the high-energy electrons and the extremely high electron density allow step-by-step ionization, but the reproducibility is poor. This chapter discusses the atomic physics background at the basis of the production of highly charged ions and describes the scientific and technological features of the most advanced ion sources. Particular attention is paid to ECRIS and the latest developments, since they now r...

  16. High intensity ultrasound modified ovalbumin: Structure, interface and gelation properties.

    Science.gov (United States)

    Xiong, Wenfei; Wang, Yuntao; Zhang, Chunlan; Wan, Jiawei; Shah, Bakht Ramin; Pei, Yaqiong; Zhou, Bin; Li, Jin; Li, Bin

    2016-07-01

    Influence of high intensity ultrasound (HIUS) on the structure and properties of ovalbumin (OVA) were investigated. It was found that the subunits and secondary structure of OVA did not change significantly with HIUS treatment from the electrophoretic patterns and circular dichroism (CD) spectrum. The amount of free sulfhydryl groups increased and intrinsic fluorescence spectra analysis indicated changes in the tertiary structure and partial unfold of OVA after sonication increased. Compared with the untreated OVA, HIUS treatment increased the emulsifying activity and foaming ability, and decreased interface tension (oil-water and air-water interface), which due to the increased surface hydrophobicity and decreased the surface net charge in OVA, while the emulsifying and foaming stability had no remarkable differences. The increased particle size may be attributed to formation of protein aggregates. Moreover, the gelation temperatures of HIUS-treated samples were higher than the untreated OVA according to the temperature sweep model rheology, and this effect was consistent with the increased in surface hydrophobicity for ultrasound treated OVA. These changes in functional properties of OVA would promote its application in food industry. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Water sorption, hardness and scanning electron microscopy evaluation of dental composite resins submitted to high-risk decay model and intensive treatment with fluoride.

    Science.gov (United States)

    Firoozmand, Leily M; de Araujo, Maria Amélia M

    2011-01-01

    The aim of this study is to assess through microhardness test, sorption test and morphological analysis, the behavior of composite resin submitted to the influence of pH cycling model and/or topic application of fluoride gels. Samples of microhybrid Z100 (3M), Estelite sigma (J Morita) and nanoparticulated Filtek Supreme (3M) composite resins were made. The Digital Scale and Vickers Digital Microhardmeter were employed to verify the water sorption and superficial microhardness, respectively. Samples were submitted to acid challenge and topical fluoride gel application. Other samples were made for the morphological analysis. The resin surface morphology in each phase of this experimental study was observed using scanning electron microscopy (SEM). The ANOVA two-way, ANOVA split plot and Tukey statistical tests were used for the statistical analysis. It was concluded that the type of composite resin can influence the water sorption, microhardness and the degree of morphologic alteration, when submitted to different experimental conditions.

  18. INTENSIVE READING: A NEW MODEL OF CLASSROOM TEACHING

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    The intensive reading class should focus on students’ reading problems and the techniques they need to become efficient readers. A model of reading technique training, including attack skills at the word, sentence and discourse level, is presented.

  19. Monitoring of intense neuromuscular blockade in a pig model

    DEFF Research Database (Denmark)

    Madsen, Matias V; Donatsky, Anders M; Jensen, Bente Rona

    2014-01-01

    .15 min after injection. We established a pig model for monitoring intense NMB with surface stimulation electrodes and acceleromyography. We verified total relaxation of the diaphragm and the abdominal muscles at the PTC 0-1 by suction test and with surface electromyography. This pig model is suitable...... for studies with experimental abdominal surgery with monitoring of intense NMB, and where relaxation of the diaphragm and the abdominal muscles are required....

  20. Production of High-Intensity, Highly Charged Ions

    OpenAIRE

    S. GamminoINFN, LNS, Catania

    2014-01-01

    In the past three decades, the development of nuclear physics facilities for fundamental and applied science purposes has required an increasing current of multicharged ion beams. Multiple ionization implies the formation of dense and energetic plasmas, which, in turn, requires specific plasma trapping configurations. Two types of ion source have been able to produce very high charge states in a reliable and reproducible way: electron beam ion sources (EBIS) and electron cyc...

  1. CW high intensity non-scaling FFAG proton drivers

    CERN Document Server

    Johnstone, C; Makino, K; Snopok, P

    2012-01-01

    Accelerators are playing increasingly important roles in basic science, technology, and medicine including nuclear power, industrial irradiation, material science, and neutrino production. Proton and light-ion accelerators in particular have many research, energy and medical applications, providing one of the most effective treatments for many types of cancer. Ultra high-intensity and high-energy (GeV) proton drivers are a critical technology for accelerator-driven sub-critical reactors (ADS) and many HEP programs (Muon Collider). These high-intensity GeV-range proton drivers are particularly challenging, encountering duty cycle and space-charge limits in the synchrotron and machine size concerns in the weaker-focusing cyclotrons; a 10-20 MW proton driver is not presently considered technically achievable with conventional re-circulating accelerators. One, as-yet, unexplored re-circulating accelerator, the Fixed-field Alternating Gradient, or FFAG, is an attractive alternative to the cyclotron. Its strong foc...

  2. Ultra High Performance, Highly Reliable, Numeric Intensive Processors and Systems

    Science.gov (United States)

    1989-10-01

    to design high-performance DSP/IP systems using either off-the-shelf components or application specific integrated circuitry [ ASIC ]. -9 - HSDAL . ARO...are the chirp-z transform ( CZT ) [13] and (Rader’s) Prime Factor Transform (PFT) [11]. The RNS/ CZT is being studied by a group a MITRE [14] and is given...PFT RNS/CRNS/QRNS implementation has dynamic range requirements on the order of NQ2 (vs NQ4 for the CZT and much higher for the FFT). Therefore, the

  3. Generation of Ultra-high Intensity Laser Pulses

    Energy Technology Data Exchange (ETDEWEB)

    N.J. Fisch; V.M. Malkin

    2003-06-10

    Mainly due to the method of chirped pulse amplification, laser intensities have grown remarkably during recent years. However, the attaining of very much higher powers is limited by the material properties of gratings. These limitations might be overcome through the use of plasma, which is an ideal medium for processing very high power and very high total energy. A plasma can be irradiated by a long pump laser pulse, carrying significant energy, which is then quickly depleted in the plasma by a short counterpropagating pulse. This counterpropagating wave effect has already been employed in Raman amplifiers using gases or plasmas at low laser power. Of particular interest here are the new effects which enter in high power regimes. These new effects can be employed so that one high-energy optical system can be used like a flashlamp in what amounts to pumping the plasma, and a second low-power optical system can be used to extract quickly the energy from the plasma and focus it precisely. The combined system can be very compact. Thus, focused intensities more than 10{sup 25} W/cm{sup 2} can be contemplated using existing optical elements. These intensities are several orders of magnitude higher than what is currently available through chirped pump amplifiers.

  4. A transparent vacuum window for high-intensity pulsed beams

    CERN Document Server

    Monteil, M; Veness, R

    2011-01-01

    The HiRadMat (High-Radiation to Materials) facility Ill will allow testing of accelerator components, in particular those of the Large Hadron Collider (LHC) at CERN, under the impact of high-intensity pulsed beams. To reach this intensity range, the beam will be focused on a focal point where the target to be tested is located. A 60 mm aperture vacuum window will separate the vacuum of the beam line which is kept under high vacuum 10(-8) mbar, from the test area which is at atmospheric pressure. This window has to resist collapse due to beam passage. The high-intensity of the beam means that typical materials used for standard vacuum windows (such as stainless steel, aluminium and titanium alloy) cannot endure the energy deposition induced by the beam passage. Therefore, a vacuum window has been designed to maintain the differential pressure whilst resisting collapse due to the beam impact on the window. In this paper, we will present calculations of the energy transfer from beam to window, the design of the ...

  5. Heat transparent high intensity high efficiency solar cell

    Science.gov (United States)

    Evans, J. C., Jr. (Inventor)

    1982-01-01

    An improved solar cell design is described. A surface of each solar cell has a plurality of grooves. Each groove has a vertical face and a slanted face that is covered by a reflecting metal. Light rays are reflected from the slanted face through the vertical face where they traverse a photovoltaic junction. As the light rays travel to the slanted face of an adjacent groove, they again traverse the junction. The underside of the reflecting coating directs the light rays toward the opposite surface of solar cell as they traverse the junction again. When the light rays travel through the solar cell and reach the saw toothed grooves on the under side, the process of reflection and repeatedly traversing the junction again takes place. The light rays ultimately emerge from the solar cell. These solar cells are particularly useful at very high levels of insolation because the infrared or heat radiation passes through the cells without being appreciably absorbed to heat the cell.

  6. High Intensity Beam Issues in the CERN Proton Synchrotron

    CERN Document Server

    Aumon, Sandra; Rivkin, Leonid

    This PhD work is about limitations of high intensity proton beams observed in the CERN Proton Synchrotron (PS) and, in particular, about issues at injection and transition energies. With its 53 years, the CERN PS would have to operate beyond the limit of its performance to match the future requirements. Beam instabilities driven by transverse impedance and aperture restrictions are important issues for the operation and for the High-Luminosity LHC upgrade which foresees an intensity increase delivered by the injectors. The main subject of the thesis concerns the study of a fast transverse instability occurring at transition energy. The proton beams crossing this energy range are particularly sensitive to wake forces because of the slow synchrotron motion. This instability can cause a strong vertical emittance blow-up and severe losses in less than a synchrotron period. Experimental observations show that the particles at the peak density of the beam longitudinal distribution oscillate in the vertical plane du...

  7. High-Intensity Focused Ultrasound Therapy: an Overview for Radiologists

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Sun; Rhim, Hyun Chul; Lim, Hyo Keun; Choi, Dong Il [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Choi, Min Joo [College of Medicine, Cheju National University, Jeju (Korea, Republic of)

    2008-08-15

    High-intensity focused ultrasound therapy is a novel, emerging, therapeutic modality that uses ultrasound waves, propagated through tissue media, as carriers of energy. This completely non-invasive technology has great potential for tumor ablation as well as hemostasis, thrombolysis and targeted drug/gene delivery. However, the application of this technology still has many drawbacks. It is expected that current obstacles to implementation will be resolved in the near future. In this review, we provide an overview of high-intensity focused ultrasound therapy from the basic physics to recent clinical studies with an interventional radiologist's perspective for the purpose of improving the general understanding of this cutting-edge technology as well as speculating on future developments

  8. High-intensity focused ultrasound therapy: an overview for radiologists.

    Science.gov (United States)

    Kim, Young-sun; Rhim, Hyunchul; Choi, Min Joo; Lim, Hyo Keun; Choi, Dongil

    2008-01-01

    High-intensity focused ultrasound therapy is a novel, emerging, therapeutic modality that uses ultrasound waves, propagated through tissue media, as carriers of energy. This completely non-invasive technology has great potential for tumor ablation as well as hemostasis, thrombolysis and targeted drug/gene delivery. However, the application of this technology still has many drawbacks. It is expected that current obstacles to implementation will be resolved in the near future. In this review, we provide an overview of high-intensity focused ultrasound therapy from the basic physics to recent clinical studies with an interventional radiologist's perspective for the purpose of improving the general understanding of this cutting-edge technology as well as speculating on future developments.

  9. Fermilab main injector: High intensity operation and beam loss control

    Science.gov (United States)

    Brown, Bruce C.; Adamson, Philip; Capista, David; Chou, Weiren; Kourbanis, Ioanis; Morris, Denton K.; Seiya, Kiyomi; Wu, Guan Hong; Yang, Ming-Jen

    2013-07-01

    From 2005 through 2012, the Fermilab Main Injector provided intense beams of 120 GeV protons to produce neutrino beams and antiprotons. Hardware improvements in conjunction with improved diagnostics allowed the system to reach sustained operation at 400 kW beam power. Transmission was very high except for beam lost at or near the 8 GeV injection energy where 95% beam transmission results in about 1.5 kW of beam loss. By minimizing and localizing loss, residual radiation levels fell while beam power was doubled. Lost beam was directed to either the collimation system or to the beam abort. Critical apertures were increased while improved instrumentation allowed optimal use of available apertures. We will summarize the improvements required to achieve high intensity, the impact of various loss control tools and the status and trends in residual radiation in the Main Injector.

  10. Modeling the intensity and polarization response of planar bolometric detectors.

    Science.gov (United States)

    Thomas, Christopher N; Withington, Stafford; Chuss, David T; Wollack, Edward J; Moseley, S Harvey

    2010-05-01

    Far-infrared bolometric detectors are used extensively in ground-based and space-borne astronomy, and thus it is important to understand their optical behavior precisely. We have studied the intensity and polarization response of free-space bolometers and shown that when the size of the absorber is reduced below a wavelength, the response changes from being that of a classical optical detector to that of a few-mode antenna. We have calculated the modal content of the reception patterns and found that for any volumetric detector having a side length of less than a wavelength, three magnetic and three electric dipoles characterize the behavior. The size of the absorber merely determines the relative strengths of the contributions. The same formalism can be applied to thin-film absorbers, where the induced current is forced to flow in a plane. In this case, one magnetic and two electric dipoles characterize the behavior. The ability to model easily the intensity, polarization, and straylight characteristics of electrically small detectors will be of great value when designing high-performance polarimetric imaging arrays.

  11. Low-intensity resistance training after high-intensity resistance training can prevent the increase of central arterial stiffness.

    Science.gov (United States)

    Okamoto, T; Masuhara, M; Ikuta, K

    2013-05-01

    Although high-intensity resistance training increases arterial stiffness, low-intensity resistance training reduces arterial stiffness. The present study investigates the effect of low-intensity resistance training before and after high-intensity resistance training on arterial stiffness. 30 young healthy subjects were randomly assigned to a group that performed low-intensity resistance training before high-intensity resistance training (BLRT, n=10), a group that performed low-intensity resistance training after high-intensity resistance training (ALRT, n=10) and a sedentary control group (n=10). The BLRT and ALRT groups performed resistance training at 80% and 50% of one repetition maximum twice each week for 10 wk. Arterial stiffness was measured using carotid-femoral and femoral-ankle pulse wave velocity (PWV). One-repetition maximum strength in the both ALRT and BLRT significantly increased after the intervention (Ptraining in the ALRT group did not change from before training. In contrast, carotid-femoral PWV after combined training in the BLRT group increased from before training (P training in the both BLRT and ALRT groups did not change from before training. These results suggest that although arterial stiffness is increased by low-intensity resistance training before high-intensity resistance training, performing low-intensity resistance training thereafter can prevent the increase of arterial stiffness. © Georg Thieme Verlag KG Stuttgart · New York.

  12. Spallation neutron source and other high intensity froton sources

    Energy Technology Data Exchange (ETDEWEB)

    Weiren Chou

    2003-02-06

    This lecture is an introduction to the design of a spallation neutron source and other high intensity proton sources. It discusses two different approaches: linac-based and synchrotron-based. The requirements and design concepts of each approach are presented. The advantages and disadvantages are compared. A brief review of existing machines and those under construction and proposed is also given. An R&D program is included in an appendix.

  13. Entrepreneurship in high-tech and knowledge-intensive sectors

    DEFF Research Database (Denmark)

    Christensen, Patrizia V.; Madsen, Henning; Neergaard, Helle

    development of new enterprises in high-tech and knowledge-intensive sectors are analysed in relation to the educational and professional background of the entrepreneur/entrepreneurial team, as well as the personal and professional social networks of the entrepreneurs. The analysis is based on a theoretical...... framework combining theories of human and social capital. Secondary aspects addressed in the research project are questions of male vs. female entrepreneurship, internationalisation-globalisation, and business success/failure....

  14. Modeling the Dependency Structure of Integrated Intensity Processes.

    Directory of Open Access Journals (Sweden)

    Yong-Ki Ma

    Full Text Available This paper studies an important issue of dependence structure. To model this structure, the intensities within the Cox processes are driven by dependent shot noise processes, where jumps occur simultaneously and their sizes are correlated. The joint survival probability of the integrated intensities is explicitly obtained from the copula with exponential marginal distributions. Subsequently, this result can provide a very useful guide for credit risk management.

  15. Compton spectra of atoms at high x-ray intensity

    Science.gov (United States)

    Son, Sang-Kil; Geffert, Otfried; Santra, Robin

    2017-03-01

    Compton scattering is the nonresonant inelastic scattering of an x-ray photon by an electron and has been used to probe the electron momentum distribution in gas-phase and condensed-matter samples. In the low x-ray intensity regime, Compton scattering from atoms dominantly comes from bound electrons in neutral atoms, neglecting contributions from bound electrons in ions and free (ionized) electrons. In contrast, in the high x-ray intensity regime, the sample experiences severe ionization via x-ray multiphoton multiple ionization dynamics. Thus, it becomes necessary to take into account all the contributions to the Compton scattering signal when atoms are exposed to high-intensity x-ray pulses provided by x-ray free-electron lasers (XFELs). In this paper, we investigate the Compton spectra of atoms at high x-ray intensity, using an extension of the integrated x-ray atomic physics toolkit, xatom. As the x-ray fluence increases, there is a significant contribution from ionized electrons to the Compton spectra, which gives rise to strong deviations from the Compton spectra of neutral atoms. The present study provides not only understanding of the fundamental XFEL-matter interaction but also crucial information for single-particle imaging experiments, where Compton scattering is no longer negligible. , which features invited work from the best early-career researchers working within the scope of J. Phys. B. This project is part of the Journal of Physics series’ 50th anniversary celebrations in 2017. Sang-Kil Son was selected by the Editorial Board of J. Phys. B as an Emerging Leader.

  16. Muscle fatigue during high-intensity exercise in children.

    Science.gov (United States)

    Ratel, Sébastien; Duché, Pascale; Williams, Craig A

    2006-01-01

    Children are able to resist fatigue better than adults during one or several repeated high-intensity exercise bouts. This finding has been reported by measuring mechanical force or power output profiles during sustained isometric maximal contractions or repeated bouts of high-intensity dynamic exercises. The ability of children to better maintain performance during repeated high-intensity exercise bouts could be related to their lower level of fatigue during exercise and/or faster recovery following exercise. This may be explained by muscle characteristics of children, which are quantitatively and qualitatively different to those of adults. Children have less muscle mass than adults and hence, generate lower absolute power during high-intensity exercise. Some researchers also showed that children were equipped better for oxidative than glycolytic pathways during exercise, which would lead to a lower accumulation of muscle by-products. Furthermore, some reports indicated that the lower ability of children to activate their type II muscle fibres would also explain their greater resistance to fatigue during sustained maximal contractions. The lower accumulation of muscle by-products observed in children may be suggestive of a reduced metabolic signal, which induces lower ratings of perceived exertion. Factors such as faster phosphocreatine resynthesis, greater oxidative capacity, better acid-base regulation, faster readjustment of initial cardiorespiratory parameters and higher removal of metabolic by-products in children could also explain their faster recovery following high-intensity exercise.From a clinical point of view, muscle fatigue profiles are different between healthy children and children with muscle and metabolic diseases. Studies of dystrophic muscles in children indicated contradictory findings of changes in contractile properties and the muscle fatigability. Some have found that the muscle of boys with Duchenne muscular dystrophy (DMD) fatigued less

  17. Intelligent Controller of Digital High Intensity Discharge Lamp

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    High-intensity discharge (HID) lamps include these types of electrical lamps: mercury vapor, metal halide (also HQI), high-pressure sodium, low-pressure sodium and less commonly, xenon short-arc lamps. The light-producing element of these lamp types is a well-stabilized arc discharge contained within a refractory envelope (arc tube) with wall loading in excess of 3 W/cm (19.4 W/in.). Compared to fluorescent and incandescent lamps, HID lamps produce a much larger quantity of light in a relatively small package. With tests made by the National Quality Supervision and

  18. The joint project for high-intensity proton accelerators

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-08-01

    Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Research Organization (KEK) agreed to promote the joint project integrating both the Neutron Science Project (NSP) of JAERI and the Japan Hadron Facility Project (JHF) of KEK for comprehensive studies on basic science and technology using high-intensity proton accelerator. This document describes the joint proposal prepared by the Joint Project Team of JAERI and KEK to construct accelerators and research facilities necessary both for the NSP and the JHF at the site of JAERI Tokai Establishment. (author)

  19. High intensity Discharge lighting; Alumbrado de alta intensidad de descarga

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza E, Ernesto J. [Manufacturera de Reactores, S. A., Mexico, D. F. (Mexico)

    1993-12-31

    This paper gets into contact with some fundamentals in the operation of high discharge intensity lamps. There are useful definitions, as well as the study of the operation of high pressure sodium lamps and of metallic additives operating at less than nominal power. [Espanol] Este trabajo pone al lector en contacto con algunos fundamentos de la operacion de las lamparas de alta intensidad de descarga (HID). Se encuentra con definiciones utiles, asi como el estudio de la operacion de las lamparas de sodio en alta presion y de aditivos metalicos operando a una potencia menor que la nominal.

  20. Removing Known SPS Intensity Limitations for High Luminosity LHC Goals

    CERN Document Server

    Shaposhnikova, Elena; Bohl, Thomas; Cruikshank, Paul; Goddard, Brennan; Kaltenbacher, Thomas; Lasheen, Alexandre; Perez Espinos, Jaime; Repond, Joël; Salvant, Benoit; Vollinger, Christine

    2016-01-01

    In preparation of the SPS as an LHC injector its impedance was significantly reduced in 1999 - 2000. A new SPS impedance reduction campaign is planned now for the High Luminosity (HL)-LHC project, which requires bunch intensities twice as high as the nominal one. One of the known intensity limitations is a longitudinal multi-bunch instability with a threshold 3 times below this operational intensity. The instability is presently cured using the 4th harmonic RF system and controlled emittance blow-up, but reaching the HL-LHC parameters cannot be assured without improving the machine impedance. Recently the impedance sources responsible for this instability were identified and implementation of their shielding and damping is foreseen during the next long shutdown (2019 - 2020) in synergy with two other important upgrades: amorphous carbon coating of (part of) the vacuum chamber against the e-cloud effect and rearrangement of the 200 MHz RF system. In this paper the strategy of impedance reduction is presented t...

  1. High-intensity positron microprobe at Jefferson Lab

    CERN Document Server

    Golge, Serkan; Wojtsekhowski, Bogdan

    2014-01-01

    We present a conceptual design for a novel continuous wave electron-linac based high-intensity slow-positron production source with a projected intensity on the order of 10$^{10}$ e$^+$/s. Reaching this intensity in our design relies on the transport of positrons (T$_+$ below 600 keV) from the electron-positron pair production converter target to a low-radiation and low-temperature area for moderation in a high-efficiency cryogenic rare gas moderator, solid Ne. The performance of the integrated beamline has been verified through computational studies. The computational results include Monte Carlo calculations of the optimized electron/positron beam energies, converter target thickness, synchronized raster system, transport of the beam from the converter target to the moderator, extraction of the beam from the channel, and moderation efficiency calculations. For the extraction of positrons from the magnetic channel a magnetic field terminator plug prototype has been built and experimental data on the effective...

  2. FNAL Proton Source High Intensity Operations and Beam Loss Control

    CERN Document Server

    Garcia, F G

    2014-01-01

    The 40-year-old Fermilab Proton Source machines, constituted by the Pre-Injector, Linac and the synchrotron Booster, have been the workhorse of the Fermi National Accelerator Laboratory (Fermilab). During this time, the High Energy Physics Program has demanded an increase in proton throughput, especially during the past decade with the beginning of the neutrino program at Fermilab. In order to achieve a successful program, major upgrades and changes were made in Booster. Once again, the Proton Source has been charged to double their beam throughput, while maintain the present residual activation levels, to meet the laboratory Intensity Frontier program goals until new machines are built and operational to replace the Proton Source machines. This paper discusses the present performance of Booster and the plans involved in reaching even higher intensities.

  3. Raman forward scattering of high-intensity chirped laser pulses

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, C.B.; Esarey, E.; Shadwick, B.A.; Leemans, W.P.

    2002-06-23

    Raman forward scattering of a high-intensity, short-duration, frequency-chirped laser pulse propagating in an underdense plasma is examined. The growth of the direct forward scattered light is calculated for a laser pulse with a linear frequency chirp in various spatio-temporal regimes. This includes a previously undescribed regime of strongly-coupled four-wave nonresonant interaction, which is important for relativistic laser intensities. In all regimes of forward scattering, it is shown that the growth rate increases (decreases) for positive (negative) frequency chirp. The effect of chirp on the growth rate is relatively minor, i.e., a few percent chirp yields few percent changes in the growth rates. Relation of these results to recent experiments is discussed.

  4. High intensity ion beams in rf undulator linac

    Directory of Open Access Journals (Sweden)

    E. S. Masunov

    2008-07-01

    Full Text Available The possibility of using a radio frequency undulator field to accelerate a high intensity ion beam in a linac is discussed. Such an accelerator can be realized using the periodical interdigital H-type resonator structure. The accelerating force is produced by an electric field which is a combination of two or more spatial harmonics, none of them being synchronous with the ion beam. The value of this force is proportional to the squared charge. The equations of motion in Hamiltonian form are derived by means of smooth approximation. The analysis of the 3D effective potential function allows finding the conditions of the beam focusing and acceleration. Two ways to increase ion beam intensity are considered: (i to enlarge beam cross section; (ii to neutralize the beam space charge by accelerating ions with opposite charge signs within the same bunch. The basic results are confirmed by a numerical simulation.

  5. The development of a high intensity dance performance fitness test.

    Science.gov (United States)

    Redding, Emma; Weller, Peter; Ehrenberg, Shantel; Irvine, Sarah; Quin, Edel; Rafferty, Sonia; Wyon, Matthew; Cox, Carol

    2009-01-01

    While there is currently a validated dance-specific exercise method of measuring aerobic fitness, no such test has been developed to measure high intensity capabilities in dance. The purpose of this study was to initiate an intermittent high intensity dance-specific fitness test. The test was designed to be able to observe changes in heart rate (HR), thereby allowing for a measurement of physical fitness at high intensities. Sixteen professional dancers (4 males and 12 females) volunteered to take part in this study. The fitness test protocol consists of movements that are representative of contemporary dance, and contains exercise and rest periods that mimic the intermittent nature of dance. The participants performed four trials. The physiological variables measured were HR (b.min(-1)) for each one minute bout of the four minute test for all trials, oxygen uptake (VO(2)) throughout the test, and end blood lactate (BLa mmol.L) for each trial. In addition, five of the participants undertook a maximal oxygen uptake treadmill test, and the scores obtained were compared with those from the dance test. Results show HR consistency across each one minute bout of the test and across each of the four trials of testing for all participants, indicating that the test is reliable. There was good reliability between bouts of each trial (typical error as % of CV = 1.5), intraclass "r" = 0.8, and good reliability between the four trials (typical error as % of CV = 2.1), intraclass "r" = 0.82. There were no significant differences between the maximal VO(2) and BLa scores established in the treadmill and dance tests, demonstrating validity. Thus, the results of this study indicate that the high intensity dance-specific test is a reliable and valid means of assessing and monitoring the cardiovascular fitness of dancers. The test allows dancers to be assessed within an environment that they are accustomed to (the studio), using a mode of exercise that is relevant (dance), and it is

  6. The different effects of high intensity interval training and moderate intensity interval training for weightlessness countermeasures

    Science.gov (United States)

    Wang, Lin-Jie; Cheng, Tan; Zhi-Li, Li; Hui-juan, Wang; Wen-juan, Chen; Jianfeng, Zhang; Desheng, Wang; Dongbin, Niu; Qi, Zhao; Chengjia, Yang; Yanqing, Wang

    High intensity interval training (HIIT) has been demonstrated to improve performance in a relatively short training period. But the difference between high intensity interval training and moderate intensity interval training (MIIT) in simulated weightlessness still has not been well studied. This study sought to characterize the difference between 6 weeks high intensity interval training and moderate intensity interval training under reduced weight (RW) gait training device and zero-gravity locomotion system (ZLS). Twenty-three subjects (14M/4F, 32.5±4.5 years) volunteered to participate. They were divided into three groups, that were MITT (alternating 2 min at 40% VO _{2} peak and 2 min at 60% VO _{2} peak for 30min, five days per week) RW group (n=8), HITT (alternating 2 min at 40% VO _{2} peak and 2 min at 90% VO _{2} peak for 30min, three days per week) RW group (n=8) and HITT ZLS group (n=7). The Z-axis load used in RW group was 80% body weight (BW) and in ZLS was 100% BW. Cardiopulmonary function was measured before, after 4-week training and after 6-week training. Isokinetic knee extension-flexion test at 60(°) deg/s and 180(°) deg/s were performed before and after the 6-week training, and isometric knee extension-flexion test at 180(°) deg/s was also examined at the same time. It was found that the VO _{2} peaks, metabolic equivalent (MET), Speedmax and respiratory exchange ratio (RER) were significantly increased after 4 and 6-week training in all three groups and no significant group difference were detected. The peak torque at 60(°) deg/s for right knee flexion were significantly increased after 6 week-training in all three groups, and only in HITT RW group the total power at 60(°) deg/s for right knee flexion enhanced. The total power and average power at 60(°) deg/s for right knee extension decreased significantly after 6-week training in all three groups. The peak torque at 60(°) deg/s for right knee extension in MIIT RW group was

  7. High Performance Human Face Recognition using Independent High Intensity Gabor Wavelet Responses: A Statistical Approach

    CERN Document Server

    Kar, Arindam; Basu, Dipak Kumar; Nasipuri, Mita; Kundu, Mahantapas

    2011-01-01

    In this paper, we present a technique by which high-intensity feature vectors extracted from the Gabor wavelet transformation of frontal face images, is combined together with Independent Component Analysis (ICA) for enhanced face recognition. Firstly, the high-intensity feature vectors are automatically extracted using the local characteristics of each individual face from the Gabor transformed images. Then ICA is applied on these locally extracted high-intensity feature vectors of the facial images to obtain the independent high intensity feature (IHIF) vectors. These IHIF forms the basis of the work. Finally, the image classification is done using these IHIF vectors, which are considered as representatives of the images. The importance behind implementing ICA along with the high-intensity features of Gabor wavelet transformation is twofold. On the one hand, selecting peaks of the Gabor transformed face images exhibit strong characteristics of spatial locality, scale, and orientation selectivity. Thus these...

  8. The effect of progressive high-intensity inspiratory muscle training and fixed high-intensity inspiratory muscle training on the asymmetry of diaphragm thickness in stroke patients

    OpenAIRE

    Jung, Ju-hyeon; Kim, Nan-soo

    2015-01-01

    [Purpose] This study investigated the effects of progressive load and fixed load high-intensity inspiratory muscle training on the asymmetry of diaphragm thickness in stroke patients. [Subjects] Twenty-one stroke patients were assigned to one of three groups: progressive load high-intensity inspiratory muscle training (n = 8), fixed load high-intensity inspiratory muscle training (n = 6), and controls (n = 7). [Methods] The progressive load and fixed load high-intensity inspiratory muscle tra...

  9. Analysis of Intensity Fluctuations of SASE using the AR Model

    CERN Document Server

    Kato, Ryukou; Isoyama, Goro; Kashiwagi, Shigeru; Okamoto, C; Suemine, Shoji; Yamamoto, Tamotsu

    2004-01-01

    We are conducting experimental study on Self-Amplified Spontaneous Emission (SASE) in the far-infrared region using the L-band linac at the Institute of Scientific and Industrial Research (ISIR), Osaka University. The intensity of SASE fluctuates intrinsically because the number of coherent optical pulses generated in an electron bunch is limited. In the actual system, however, another factor producing intensity fluctuations also shows up, which is instability of the linac. Generally speaking, it is difficult to distinguish contributions of these two factors in measured intensity fluctuations. We have applied the autoregressive (AR) model, which is one of the techniques of statistical analysis, to exclude contributions of linac instability from measured data. In the AR model, the present data can be expressed with a linear combination of the past data plus white noise. In the analysis, contributions of the linac instability are identified with the AR model and can be subtracted from the measured data of SASE,...

  10. Effects of intensity and duration in aerobic high-intensity interval training in highly trained junior cross-country skiers.

    Science.gov (United States)

    Sandbakk, Øyvind; Sandbakk, Silvana B; Ettema, Gertjan; Welde, Boye

    2013-07-01

    The purpose of this study was to test whether a long duration of aerobic high-intensity interval training is more effective than shorter intervals at a higher intensity in highly trained endurance athletes. The sample comprised of 12 male and 9 female, national-level, junior cross-country skiers (age, 17.5 ± 0.4 years, maximal oxygen uptake (V[Combining Dot Above]O2max): 67.4 ± 7.7 ml min kg), who performed 8-week baseline and 8-week intervention training periods on dry land. During the intervention period, a short-interval group (SIG, n = 7) added 2 weekly sessions with short duration intervals (2- to 4-minute bouts, total duration of 15-20 minutes), a long-interval group (LIG; n = 7) added 2 weekly sessions with long duration intervals (5- to 10-minute bouts, total duration of 40-45 minutes). The interval sessions were performed with the athletes' maximal sustainable intensity. A control group (CG; n = 7) added 2 weekly sessions with low-intensity endurance training at 65-74% of maximal heart rate. Before and after the intervention period, the skiers were tested for time-trial performance on 12-km roller-ski skating and 7-km hill run. V[Combining Dot Above]O2max and oxygen uptake at the ventilatory threshold (V[Combining Dot Above]O2VT) were measured during treadmill running. After the intervention training period, the LIG-improved 12-km roller ski, 7-km hill run, V[Combining Dot Above]O2max, and V[Combining Dot Above]O2VT by 6.8 ± 4.0%, 4.8 ± 2.6%, 3.7 ± 1.6%, and 5.8 ± 3.3%, respectively, from pre- to posttesting, and improved both performance tests and V[Combining Dot Above]O2VT when compared with the SIG and the CG (all p < 0.05). The SIG improved V[Combining Dot Above]O2max by 3.5 ± 3.2% from pre- to posttesting (p < 0.05), whereas the CG remained unchanged. As hypothesized, a long duration of aerobic high-intensity interval training improved endurance performance and oxygen uptake at the ventilatory threshold more than shorter intervals at a higher

  11. Electron cloud instability in high intensity proton rings

    Directory of Open Access Journals (Sweden)

    K. Ohmi

    2002-11-01

    Full Text Available An e^{-}p instability has been observed in some proton rings. The instability, which causes beam loss, limits the performance of the ring. The instability may be serious for 3 and 50 GeV proton storage rings in the Japan Proton Accelerator Research Complex (J-PARC. We study the e^{-}p instability in several high intensity proton storage rings operated in the world. This work informs J-PARC of the necessity to cure the instability, for example, by applying a TiN coating on the chamber surface.

  12. Beam instrumentation for future high intense hadron accelerators at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Wendt, M.; Hu, M.; Tassotto, G.; Thurman-Keup, R.; Scarpine, V.; Shin, S.; Zagel, J.; /Fermilab

    2008-08-01

    High intensity hadron beams of up to 2 MW beam power are a key element of new proposed experimental facilities at Fermilab. Project X, which includes a SCRF 8 GeV H{sup -} linac, will be the centerpiece of future HEP activities in the neutrino sector. After a short overview of this, and other proposed projects, we present the current status of the beam instrumentation activities at Fermilab with a few examples. With upgrades and improvements they can meet the requirements of the new beam facilities, however design and development of new instruments is needed, as shown by the prototype and conceptual examples in the last section.

  13. Development of High Intensity Beam Emittance Measurement Unit

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Three sets of High Intensity Beam Emittance Measurement Units (HIBEMUs) are being developed at Peking University. They are HIBEMU-2 (slit-wire type, one direction), HIBEMU-3 (Allison scanner type, one direction) and HIBEMU-4 (slit-wire type, two directions). For HIBEMU-2 and HIBEMU-3, more recent work has been done on software redesign in order to measure beam emittance and to draw phase diagram more efficiently and precisely. Software for control and data processing of them were developed in Labveiw environment, trying to improve calculation rationality and to offer user-friendly interface. Mechanical modification was also done for HIBEMU-3, mainly concentrating on the protection of Faraday cups from being overheated by the high intensity beam and also from interference of secondary electrons. This paper will also cover the mechanical structure as well as the software development of HIBEMU-4, which is a two-direction emittance scanner newly designed and manufactured for the high energy beam transport (HEBT) of Peking University Neutron Imaging FaciliTY (PKUNIFTY). At the end of this paper, comparison and analysis of the three HIBEMUs are given to draw forth better design of the future emittance measurement facility.

  14. High Intensity Focused Ultrasound Tumor Therapy System and Its Application

    Science.gov (United States)

    Sun, Fucheng; He, Ye; Li, Rui

    2007-05-01

    At the end of last century, a High Intensity Focused Ultrasound (HIFU) tumor therapy system was successfully developed and manufactured in China, which has been already applied to clinical therapy. This article aims to discuss the HIFU therapy system and its application. Detailed research includes the following: power amplifiers for high-power ultrasound, ultrasound transducers with large apertures, accurate 3-D mechanical drives, a software control system (both high-voltage control and low-voltage control), and the B-mode ultrasonic diagnostic equipment used for treatment monitoring. Research on the dosage of ultrasound required for tumour therapy in multiple human cases has made it possible to relate a dosage formula, presented in this paper, to other significant parameters such as the volume of thermal tumor solidification, the acoustic intensity (I), and the ultrasound emission time (tn). Moreover, the HIFU therapy system can be applied to the clinical treatment of both benign and malignant tumors in the pelvic and abdominal cavity, such as uterine fibroids, liver cancer and pancreatic carcinoma.

  15. Impact of the dipole-moment representation on the intensity of high overtones

    Science.gov (United States)

    Medvedev, Emile S.; Meshkov, Vladimir V.; Stolyarov, Andrey V.; Ushakov, Vladimir G.; Gordon, Iouli E.

    2016-12-01

    Calculating intensities of ro-vibrational transitions is particularly challenging for transitions from a given vibrational state to all upper states up to the dissociation limit because their probabilities decrease exponentially with increasing Δn , the change in the vibrational quantum number. The experimental intensities available for low- Δn values are well reproduced by a variety of models but the models can greatly diverge in predicting the intensities of unobserved high-overtone transitions, the divergence rapidly increasing with the overtone number. In this paper, we investigate the impact of the dipole-moment function (DMF) representation on the high-overtone intensity simulation of the CO molecule. We tested various DMF forms including pointwise representation combined with cubic-spline interpolation, power and trigonometric expansions, and Padé approximants. Numerical calculations were performed with the highly accurate empirical potential-energy function (PEF) of Coxon and Hajigeorgiou (2004) using quadruple-precision arithmetic. Most calculated intensities fall off in the entire range of transitions according to the Normal Intensity Distribution Law (NIDL) (Medvedev, 2012). The slope of the NIDL trend line varies little between different analytical DMFs for a given PEF since the slope is basically associated with the PEF. Based on the NIDL, the limits within which the simulated intensities fall off up to the dissociation limit can be established. We claim that DMFs represented by analytical functions yield best results for all transitions. The pointwise functions (interpolated, in particular, by the conventional cubic splines) result in an unphysical flattening of the intensities at high- Δn transitions, Δn > 7 for CO.

  16. Study in Parkinson Disease of Exercise (SPARX): Translating high-intensity exercise from animals to humans

    Science.gov (United States)

    Moore, Charity G.; Schenkman, Margaret; Kohrt, Wendy M.; Delitto, Anthony; Hall, Deborah A.; Corcos, Daniel

    2013-01-01

    A burgeoning literature suggests that exercise has a therapeutic benefit in persons with Parkinson disease (PD) and in animal models of PD, especially when animals exercise at high intensity. If exercise is to be prescribed as “first-line” or “add-on” therapy in patients with PD, we must demonstrate its efficacy and dose-response effects through testing phases similar to those used in the testing of pharmacologic agents. The SPARX Trial is a multicenter, randomized, controlled, single-blinded, Phase II study that we designed to test the feasibility of using high-intensity exercise to modify symptoms of PD and to simultaneously test the nonfutility of achieving a prespecified change in patients’ motor scores on the Unified Parkinson Disease Rating Scale (UPDRS). The trial began in May 2102 and is in the process of screening, enrolling, and randomly assigning 126 patients with early-stage PD to 1 of 3 groups: usual care (wait-listed controls), moderate-intensity exercise (4 days/week at 60%–65% maximal heart rate [HRmax]), or high-intensity exercise (4 days/week at 80%–85% HRmax). At 6-month follow-up, the trial is randomly reassigning usual care participants to a moderate-intensity or high-intensity exercise group for the remaining 6 months. The goals of the Phase II trial are to determine if participants can exercise at moderate and high intensities; to determine if either exercise yields benefits consistent with meaningful clinical change (nonfutility); and to document safety and attrition. The advantage of using a non-futility approach allows us to efficiently determine if moderate- or high-intensity exercise warrants further large-scale investigation in PD. PMID:23770108

  17. Hot electron generation and energy coupling in planar experiments with shock ignition high intensity lasers

    Science.gov (United States)

    Wei, M. S.; Krauland, C.; Alexander, N.; Zhang, S.; Peebles, J.; Beg, F. N.; Theobald, W.; Borwick, E.; Ren, C.; Yan, R.; Haberberger, D.; Betti, R.; Campbell, E. M.

    2016-10-01

    Hot electrons produced in nonlinear laser plasma interactions are critical issues for shock ignition (SI) laser fusion. We conducted planar target experiments to characterize hot electron and energy coupling using the high energy OMEGA EP laser system at SI high intensities. Targets were multilayered foils consisting of an ablator (either plastic or lithium) and a Cu layer to facilitate hot electron detection via fluorescence and bremsstrahlung measurements. The target was first irradiated by multi-kJ, low-intensity UV beams to produce a SI-relevant mm-scale hot ( 1 keV) preformed plasma. The main interaction pulse, either a kJ 1-ns UV pulse with intensity 1.6x1016 Wcm-2 or a kJ 0.1-ns IR pulse with intensity up to 2x1017 Wcm-2was injected at varied timing delays. The high intensity IR beam was found to strongly interact with underdense plasmas breaking into many filaments near the quarter critical density region followed by propagation of those filaments to critical density, producing hot electrons with Thot 70 keV in a well-contained beam. While the high intensity UV beam showed poor energy coupling. Details of the experiments and the complementary PIC modeling results will be presented. Work supported by U.S. DOE under contracts DE-NA0002730 (NLUF) and DE-SC0014666 (HEDLP).

  18. High-Intensity Interval Training Elicits Higher Enjoyment than Moderate Intensity Continuous Exercise.

    Science.gov (United States)

    Thum, Jacob S; Parsons, Gregory; Whittle, Taylor; Astorino, Todd A

    2017-01-01

    Exercise adherence is affected by factors including perceptions of enjoyment, time availability, and intrinsic motivation. Approximately 50% of individuals withdraw from an exercise program within the first 6 mo of initiation, citing lack of time as a main influence. Time efficient exercise such as high intensity interval training (HIIT) may provide an alternative to moderate intensity continuous exercise (MICT) to elicit substantial health benefits. This study examined differences in enjoyment, affect, and perceived exertion between MICT and HIIT. Twelve recreationally active men and women (age = 29.5 ± 10.7 yr, VO2max = 41.4 ± 4.1 mL/kg/min, BMI = 23.1 ± 2.1 kg/m2) initially performed a VO2max test on a cycle ergometer to determine appropriate workloads for subsequent exercise bouts. Each subject returned for two additional exercise trials, performing either HIIT (eight 1 min bouts of cycling at 85% maximal workload (Wmax) with 1 min of active recovery between bouts) or MICT (20 min of cycling at 45% Wmax) in randomized order. During exercise, rating of perceived exertion (RPE), affect, and blood lactate concentration (BLa) were measured. Additionally, the Physical Activity Enjoyment Scale (PACES) was completed after exercise. Results showed higher enjoyment (p = 0.013) in response to HIIT (103.8 ± 9.4) versus MICT (84.2 ± 19.1). Eleven of 12 participants (92%) preferred HIIT to MICT. However, affect was lower (pHIIT versus MICT. Although HIIT is more physically demanding than MICT, individuals report greater enjoyment due to its time efficiency and constantly changing stimulus.

  19. High-Intensity Sweeteners in Alternative Tobacco Products.

    Science.gov (United States)

    Miao, Shida; Beach, Evan S; Sommer, Toby J; Zimmerman, Julie B; Jordt, Sven-Eric

    2016-11-01

    Sweeteners in tobacco products may influence use initiation and reinforcement, with special appeal to adolescents. Recent analytical studies of smokeless tobacco products (snuff, snus, dissolvables) detected flavorants identical to those added to confectionary products such as hard candy and chewing gum. However, these studies did not determine the levels of sweeteners. The objective of the present study was to quantify added sweeteners in smokeless tobacco products, a dissolvable product, electronic cigarette liquids and to compare with sweetener levels in confectionary products. Sweetener content of US-sourced smokeless tobacco, electronic cigarette liquid, and confectionary product samples was analyzed by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). All smokeless products contained synthetic high intensity sweeteners, with snus and dissolvables exceeding levels in confectionary products (as much as 25-fold). All snus samples contained sucralose and most also aspartame, but no saccharin. In contrast, all moist snuff samples contained saccharin. The dissolvable sample contained sucralose and sorbitol. Ethyl maltol was the most common sweet-associated component in electronic cigarette liquids. Sweetener content was dependent on product category, with saccharin in moist snuff, an older category, sucralose added at high levels to more recently introduced products (snus, dissolvable) and ethyl maltol in electronic cigarette liquid. The very high sweetener concentrations may be necessary for the consumer to tolerate the otherwise aversive flavors of tobacco ingredients. Regulation of sweetener levels in smokeless tobacco products may be an effective measure to modify product attractiveness, initiation and use patterns. Dissolvables, snus and electronic cigarettes have been promoted as risk-mitigation products due to their relatively low content of nitrosamines and other tobacco toxicants. This study is the first to quantify high

  20. High-Intensity Sweeteners in Alternative Tobacco Products

    Science.gov (United States)

    Miao, Shida; Beach, Evan S.; Sommer, Toby J.; Zimmerman, Julie B.

    2016-01-01

    Introduction: Sweeteners in tobacco products may influence use initiation and reinforcement, with special appeal to adolescents. Recent analytical studies of smokeless tobacco products (snuff, snus, dissolvables) detected flavorants identical to those added to confectionary products such as hard candy and chewing gum. However, these studies did not determine the levels of sweeteners. The objective of the present study was to quantify added sweeteners in smokeless tobacco products, a dissolvable product, electronic cigarette liquids and to compare with sweetener levels in confectionary products. Methods: Sweetener content of US-sourced smokeless tobacco, electronic cigarette liquid, and confectionary product samples was analyzed by liquid chromatography-electrospray ionization–mass spectrometry (LC-ESI-MS). Results: All smokeless products contained synthetic high intensity sweeteners, with snus and dissolvables exceeding levels in confectionary products (as much as 25-fold). All snus samples contained sucralose and most also aspartame, but no saccharin. In contrast, all moist snuff samples contained saccharin. The dissolvable sample contained sucralose and sorbitol. Ethyl maltol was the most common sweet-associated component in electronic cigarette liquids. Discussion: Sweetener content was dependent on product category, with saccharin in moist snuff, an older category, sucralose added at high levels to more recently introduced products (snus, dissolvable) and ethyl maltol in electronic cigarette liquid. The very high sweetener concentrations may be necessary for the consumer to tolerate the otherwise aversive flavors of tobacco ingredients. Regulation of sweetener levels in smokeless tobacco products may be an effective measure to modify product attractiveness, initiation and use patterns. Implications: Dissolvables, snus and electronic cigarettes have been promoted as risk-mitigation products due to their relatively low content of nitrosamines and other tobacco

  1. Further Evaluation of a Brief, Intensive Teacher-Training Model

    Science.gov (United States)

    Lerman, Dorothea C.; Tetreault, Allison; Hovanetz, Alyson; Strobel, Margaret; Garro, Joanie

    2008-01-01

    The purpose of this study was to further evaluate the outcomes of a model program that was designed to train current teachers of children with autism. Nine certified special education teachers participating in an intensive 5-day summer training program were taught a relatively large number of specific skills in two areas (preference assessment and…

  2. Longitudinal tracking studies for a high intensity proton synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Lessner, E.; Cho, Y.; Harkay, K.; Symon, K. [Argonne National Laboratory, 9700 Cass Ave., Argonne, Illinois 60439 (United States)

    1996-06-01

    Results from longitudinal tracking studies for a high intensity proton synchrotron designed for a 1-MW spallation source are presented. The machine delivers a proton beam of 0.5 mA time-averaged current at a repetition rate of 30 Hz. The accelerator is designed to have radiation levels that allow hands-on-maintenance. However, the high beam intensity causes strong space charge fields whose effects may lead to particle loss and longitudinal instabilities. The space charge fields modify the particle distribution, distort the stable bucket area and reduce the rf linear restoring force. Tracking simulations were conducted to analyze the space charge effects on the dynamics of the injection and acceleration processes and means to circumvent them. The tracking studies led to the establishment of the injected beam parameters and rf voltage program that minimized beam loss and longitudinal instabilities. Similar studies for a 10-GeV synchrotron that uses the 2-GeV synchrotron as its injector are also discussed. {copyright} {ital 1996 American Institute of Physics.}

  3. Formation of a high intensity low energy positron string

    Science.gov (United States)

    Donets, E. D.; Donets, E. E.; Syresin, E. M.; Itahashi, T.; Dubinov, A. E.

    2004-05-01

    The possibility of a high intensity low energy positron beam production is discussed. The proposed Positron String Trap (PST) is based on the principles and technology of the Electron String Ion Source (ESIS) developed in JINR during the last decade. A linear version of ESIS has been used successfully for the production of intense highly charged ion beams of various elements. Now the Tubular Electron String Ion Source (TESIS) concept is under study and this opens really new promising possibilities in physics and technology. In this report, we discuss the application of the tubular-type trap for the storage of positrons cooled to the cryogenic temperatures of 0.05 meV. It is intended that the positron flux at the energy of 1-5 eV, produced by the external source, is injected into the Tubular Positron Trap which has a similar construction as the TESIS. Then the low energy positrons are captured in the PST Penning trap and are cooled down because of their synchrotron radiation in the strong (5-10 T) applied magnetic field. It is expected that the proposed PST should permit storing and cooling to cryogenic temperature of up to 5×109 positrons. The accumulated cooled positrons can be used further for various physics applications, for example, antihydrogen production.

  4. Use of High Intensity Focused Ultrasound for Treating Malignant Tumors

    Institute of Scientific and Technical Information of China (English)

    WenzhiChen; ZhibiaoWang; FengWu; JinBai; HuiZhu; JianzhongZou; KequanLi; FanglinXie; ZhilongWang

    2004-01-01

    OBJECTIVE To investigate the efficacy and side effects of high intensity focused ultrasound(HIFU) in the treatment of malignant solid tumors. METHODS Thirty patients who refused surgery and/or were refractory to chemotherapy were treated by HIFU alone, with the efficacy and side effects monitored as follows: observation of vital organ signs; functional assay of important organs; imaging examinations including: digital subtraction angiography (DSA), CT, MRI, single photon emission computed tomography (SPECT), large core needle biopsy, complications and metastasis. RESULTS After HIFU therapy, the vital signs remained stable and the functions of the heart, lung, kidney and liver were also normal. DSA images showed that small or larger arteries were not damaged. After a follow-up of 10-38 months(mean 23.1 months), 26 patients(87%) were alive. The volume of the tumor underwent complete regression in 10 patients. Shrinkage of the tumor volume ≥50% was observed in 13 patients. Eight of 13 patients were examined by large core needle biopsy, all showing necrosis and/or fibrosis though 3 patients(10%) had local recurrence. Two of these were retreated again by HIFU and the locally recurrent tumors were controlled. New metastases developed in 5 patients after H IFU. Two patients suffered from peripheral nerve injuriy and they have recovered during the follow-up. One patient developed skin injury. CONCLUSION High intensity focused ultrasound is effective and safe in the treatment of malignant solid tumors.

  5. High Intensity Pressure Noise Transmission in Human Ear: A Three Dimensional Simulation Study

    Science.gov (United States)

    Hawa, Takumi; Gan, Rong; Leckness, Kegan

    2015-03-01

    High intensity pressure noise generated by explosions and jet engines causes auditory damage and hearing loss of the military service personals, which are the most common disabilities in the veterans. Authors have investigated the high intensity pressure noise transmission from the ear canal to middle ear cavity. A fluid-structure interaction with a viscoelastic model for the tympanic membrane (TM) as well as the ossicular chain has been considered in the study. For the high intensity pressure simulation the geometry of the ear was based on a 3D finite element (FE) model of the human ear reported by Gan et al. (Ann Biomed Eng 2004). The model consists of the ear canal, TM, ossicular chain, and the middle ear cavity. The numerical approach includes two steps: 1) FE based finite-volume method simulation to compute pressure distributions in the ear canal and the middle ear cavity using CFX; and 2) FE modeling of TM and middle ear ossicles in response to high intensity sound using multi-physics analysis in ANSYS. The simulations provide the displacement of the TM/ossicular chain and the pressure fields in the ear canal and the middle ear cavity. These results are compared with human temporal bone experimental data obtained in our group. This work was supported by DOD W81XWH-14-1-0228.

  6. Ultra-High Intensity Magnetic Field Generation in Dense Plasma

    Energy Technology Data Exchange (ETDEWEB)

    Fisch, Nathaniel J. [Princeton Univ., NJ (United States)

    2014-01-08

    The main objective of this grant proposal was to explore the efficient generation of intense currents. Whereas the efficient generation of electric current in low-­energy-­density plasma has occupied the attention of the magnetic fusion community for several decades, scant attention has been paid to carrying over to high-­energy-­density plasma the ideas for steady-­state current drive developed for low-­energy-­density plasma, or, for that matter, to inventing new methodologies for generating electric current in high-­energy-­density plasma. What we proposed to do was to identify new mechanisms to accomplish current generation, and to assess the operation, physics, and engineering basis of new forms of current drive in regimes appropriate for new fusion concepts.

  7. Increased collection efficiency of LIFI high intensity electrodeless light source

    Science.gov (United States)

    Hafidi, Abdeslam; DeVincentis, Marc; Duelli, Markus; Gilliard, Richard

    2008-02-01

    Recently, RF driven electrodeless high intensity light sources have been implemented successfully in the projection display systems for HDTV and videowall applications. This paper presents advances made in the RF waveguide and electric field concentrator structures with the purpose of reducing effective arc size and increasing light collection. In addition, new optical designs are described that further improve system efficiency. The results of this work demonstrate that projection system light throughput is increased relative to previous implementations and performance is optimized for home theater and other front projector applications that maintain multi-year lifetime without re-lamping, complete spectral range, fast start times and high levels of dynamic contrast due to dimming flexibility in the light source system.

  8. Generation And Measurement Of High Contrast Ultrashort Intense Laser Pulses

    CERN Document Server

    Konoplev, O A

    2000-01-01

    In this thesis, the generation and measurement of high contrast, intense, ultrashort pulses have been studied. Various factors affecting the contrast and pulse shape of ultrashort light pulses from a chirped pulse amplification (CPA) laser system are identified. The level of contrast resulting from influence of these factors is estimated. Methods for improving and controlling the pulse shape and increasing the contrast are discussed. Ultrahigh contrast, 1-ps pulses were generated from a CPA system with no temporal structure up to eleven orders of magnitude. This is eight orders of magnitude higher contrast than the original pulse. This contrast boost was achieved using two techniques. One is the optical pulse cleaning based on the nonlinear birefringence of the chirping fiber and applied to the pulses before amplification. The other is the fast saturable absorber. The fast saturable absorber was placed after amplification and compression of the pulse. The measurements of high-contrast, ultrashort pulse with h...

  9. Ultra-High Intensity Magnetic Field Generation in Dense Plasma

    Energy Technology Data Exchange (ETDEWEB)

    Fisch, Nathaniel J

    2014-01-08

    I. Grant Objective The main objective of this grant proposal was to explore the efficient generation of intense currents. Whereasthefficient generation of electric current in low-­energy-­density plasma has occupied the attention of the magnetic fusion community for several decades, scant attention has been paid to carrying over to high-­energy-­density plasma the ideas for steady-­state current drive developed for low-­energy-­density plasma, or, for that matter, to inventing new methodologies for generating electric current in high-­energy-­density plasma. What we proposed to do was to identify new mechanisms to accomplish current generation, and to assess the operation, physics, and engineering basis of new forms of current drive in regimes appropriate for new fusion concepts.

  10. Optical Fiber High Temperature Sensor Instrumentation for Energy Intensive Industries

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Kristie L.; Wang, Anbo; Pickrell, Gary R.

    2006-11-14

    This report summarizes technical progress during the program “Optical Fiber High Temperature Sensor Instrumentation for Energy Intensive Industries”, performed by the Center for Photonics Technology of the Bradley Department of Electrical and Computer Engineering at Virginia Tech. The objective of this program was to use technology recently invented at Virginia Tech to develop and demonstrate the application of self-calibrating optical fiber temperature and pressure sensors to several key energy-intensive industries where conventional, commercially available sensors exhibit greatly abbreviated lifetimes due primarily to environmental degradation. A number of significant technologies were developed under this program, including • a laser bonded silica high temperature fiber sensor with a high temperature capability up to 700°C and a frequency response up to 150 kHz, • the world’s smallest fiber Fabry-Perot high temperature pressure sensor (125 x 20 μm) with 700°C capability, • UV-induced intrinsic Fabry-Perot interferometric sensors for distributed measurement, • a single crystal sapphire fiber-based sensor with a temperature capability up to 1600°C. These technologies have been well demonstrated and laboratory tested. Our work plan included conducting major field tests of these technologies at EPRI, Corning, Pratt & Whitney, and Global Energy; field validation of the technology is critical to ensuring its usefulness to U.S. industries. Unfortunately, due to budget cuts, DOE was unable to follow through with its funding commitment to support Energy Efficiency Science Initiative projects and this final phase was eliminated.

  11. Relativistic electron mirrors from high intensity laser nanofoil interactions

    Energy Technology Data Exchange (ETDEWEB)

    Kiefer, Daniel

    2012-12-21

    The reflection of a laser pulse from a mirror moving close to the speed of light could in principle create an X-ray pulse with unprecedented high brightness owing to the increase in photon energy and accompanying temporal compression by a factor of 4γ{sup 2}, where γ is the Lorentz factor of the mirror. While this scheme is theoretically intriguingly simple and was first discussed by A. Einstein more than a century ago, the generation of a relativistic structure which acts as a mirror is demanding in many different aspects. Recently, the interaction of a high intensity laser pulse with a nanometer thin foil has raised great interest as it promises the creation of a dense, attosecond short, relativistic electron bunch capable of forming a mirror structure that scatters counter-propagating light coherently and shifts its frequency to higher photon energies. However, so far, this novel concept has been discussed only in theoretical studies using highly idealized interaction parameters. This thesis investigates the generation of a relativistic electron mirror from a nanometer foil with current state-of-the-art high intensity laser pulses and demonstrates for the first time the reflection from those structures in an experiment. To achieve this result, the electron acceleration from high intensity laser nanometer foil interactions was studied in a series of experiments using three inherently different high power laser systems and free-standing foils as thin as 3nm. A drastic increase in the electron energies was observed when reducing the target thickness from the micrometer to the nanometer scale. Quasi-monoenergetic electron beams were measured for the first time from ultrathin (≤5nm) foils, reaching energies up to ∝35MeV. The acceleration process was studied in simulations well-adapted to the experiments, indicating the transition from plasma to free electron dynamics as the target thickness is reduced to the few nanometer range. The experience gained from those

  12. Outcomes of exertional rhabdomyolysis following high-intensity resistance training.

    Science.gov (United States)

    Huynh, A; Leong, K; Jones, N; Crump, N; Russell, D; Anderson, M; Steinfort, D; Johnson, D F

    2016-05-01

    High-intensity resistance training (HIRT) programmes are increasingly popular amongst personal trainers and those attending gymnasiums. We report the experience of exertional rhabdomyolysis (ER) at two tertiary hospitals in Melbourne, Australia. To compare the clinical outcomes of ER with other causes of rhabdomyolysis. Retrospective cross-sectional study of patients presenting with a serum creatine kinase (CK) of greater than 25 000 units/L from 1 September 2013 to 31 August 2014 at two tertiary referral hospitals in Melbourne, Australia. Records were examined to identify care measures implemented during hospital stay, clinical outcomes during admission and on subsequent follow up. Thirty four cases of rhabdomyolysis with a CK of greater than 25 000 units/L (normal range: 20-180 units/L) were identified during the 12-month study period. Twelve of the 34 cases (35%) had ER with 10 of 12 related to HIRT. No acute kidney injury, intensive care admission or death were seen among those with ER. All cases were managed conservatively, with 11 admitted and 9 receiving intravenous fluids only. In contrast, patients with rhabdomyolysis from other causes experienced significantly higher rates of intensive care admission (64%, P = 0.0002), acute kidney injury (82%, P = 0.0001) and death (27%, P = 0.069). ER resulting from HIRT appears to have a benign course compared with rhabdomyolysis of other aetiologies in patients with a serum CK greater than 25 000 units/L. Conservative management of ER appears to be adequate, although this requires confirmation in future prospective studies. © 2016 Royal Australasian College of Physicians.

  13. Intensity dependence in high-level facial expression adaptation aftereffect.

    Science.gov (United States)

    Hong, Sang Wook; Yoon, K Lira

    2017-06-14

    Perception of a facial expression can be altered or biased by a prolonged viewing of other facial expressions, known as the facial expression adaptation aftereffect (FEAA). Recent studies using antiexpressions have demonstrated a monotonic relation between the magnitude of the FEAA and adaptor extremity, suggesting that facial expressions are opponent coded and represented continuously from one expression to its antiexpression. However, it is unclear whether the opponent-coding scheme can account for the FEAA between two facial expressions. In the current study, we demonstrated that the magnitude of the FEAA between two facial expressions increased monotonically as a function of the intensity of adapting facial expressions, consistent with the predictions based on the opponent-coding model. Further, the monotonic increase in the FEAA occurred even when the intensity of an adapting face was too weak for its expression to be recognized. These results together suggest that multiple facial expressions are encoded and represented by balanced activity of neural populations tuned to different facial expressions.

  14. Hybrid simulation models for data-intensive systems

    CERN Document Server

    Barisits, Martin

    Data-intensive systems are used to access and store massive amounts of data by combining the storage resources of multiple data-centers, usually deployed all over the world, in one system. This enables users to utilize these massive storage capabilities in a simple and efficient way. However, with the growth of these systems it becomes a hard problem to estimate the effects of modifications to the system, such as data placement algorithms or hardware upgrades, and to validate these changes for potential side effects. This thesis addresses the modeling of operational data-intensive systems and presents a novel simulation model which estimates the performance of system operations. The running example used throughout this thesis is the data-intensive system Rucio, which is used as the data man- agement system of the ATLAS experiment at CERN’s Large Hadron Collider. Existing system models in literature are not applicable to data-intensive workflows, as they only consider computational workflows or make assumpti...

  15. Application of High Intensity THz Pulses for Gas High Harmonic Generation

    CERN Document Server

    Balogh, Emeric; Hebling, János; Dombi, Péter; Farkas, Győző; Varjú, Katalin

    2013-01-01

    The main effects of an intense THz pulse on gas high harmonic generation are studied via trajectory analysis on the single atom level. Spectral and temporal modifications to the generated radiation are highlighted.

  16. Stabilizing the intensity for a Hamiltonian model of the FEL

    CERN Document Server

    Bachelard, R; Fanelli, D; Leoncini, X; Vittot, M

    2008-01-01

    The intensity of an electromagnetic wave interacting self-consistently with a beam of charged particles, as in a Free Electron Laser, displays large oscillations due to an aggregate of particles, called the macro-particle. In this article, we propose a strategy to stabilize the intensity by destabilizing the macro-particle. This strategy involves the study of the linear stability of a specific periodic orbit of a mean-field model. As a control parameter - the amplitude of an external wave - is varied, a bifurcation occur in the system which has drastic effects on the self-consistent dynamics, and in particular, on the macro-particle. We show how to obtain an appropriate tuning of the control parameter which is able to strongly decrease the oscillations of the intensity without reducing its mean-value.

  17. Stabilizing the intensity for a Hamiltonian model of the FEL

    Energy Technology Data Exchange (ETDEWEB)

    Bachelard, R. [Centre de Physique Theorique, CNRS Luminy, Case 907, F-13288 Marseille Cedex 9 (France)], E-mail: bachelard@cpt.univ-mrs.fr; Chandre, C. [Centre de Physique Theorique, CNRS Luminy, Case 907, F-13288 Marseille Cedex 9 (France); Fanelli, D. [Theoretical Physics Group, School of Physics and Astronomy, University of Manchester, Manchester, M13 9PL (United Kingdom); Leoncini, X.; Vittot, M. [Centre de Physique Theorique, CNRS Luminy, Case 907, F-13288 Marseille Cedex 9 (France)

    2008-08-01

    The intensity of an electromagnetic wave interacting self-consistently with a beam of charged particles, as in a Free Electron Laser, displays large oscillations due to an aggregate of particles, called the macro-particle. In this article, we propose a strategy to stabilize the intensity by destabilizing the macro-particle. This strategy involves the study of the linear stability of a specific periodic orbit of a mean-field model. As a control parameter-the amplitude of an external wave-is varied, a bifurcation occurs in the system which has drastic effects on the self-consistent dynamics, and in particular, on the macro-particle. We show how to obtain an appropriate tuning of the control parameter which is able to strongly decrease the oscillations of the intensity without reducing its mean-value.

  18. Semicircular Canal Pressure Changes During High-intensity Acoustic Stimulation.

    Science.gov (United States)

    Maxwell, Anne K; Banakis Hartl, Renee M; Greene, Nathaniel T; Benichoux, Victor; Mattingly, Jameson K; Cass, Stephen P; Tollin, Daniel J

    2017-08-01

    Acoustic stimulation generates measurable sound pressure levels in the semicircular canals. High-intensity acoustic stimuli can cause hearing loss and balance disruptions. To examine the propagation of acoustic stimuli to the vestibular end-organs, we simultaneously measured fluid pressure in the cochlea and semicircular canals during both air- and bone-conducted sound presentation. Five full-cephalic human cadaveric heads were prepared bilaterally with a mastoidectomy and extended facial recess. Vestibular pressures were measured within the superior, lateral, and posterior semicircular canals, and referenced to intracochlear pressure within the scala vestibuli with fiber-optic pressure probes. Pressures were measured concurrently with laser Doppler vibrometry measurements of stapes velocity during stimulation with both air- and bone-conduction. Stimuli were pure tones between 100 Hz and 14 kHz presented with custom closed-field loudspeakers for air-conducted sounds and via commercially available bone-anchored device for bone-conducted sounds. Pressures recorded in the superior, lateral, and posterior semicircular canals in response to sound stimulation were equal to or greater in magnitude than those recorded in the scala vestibuli (up to 20 dB higher). The pressure magnitudes varied across canals in a frequency-dependent manner. High sound pressure levels were recorded in the semicircular canals with sound stimulation, suggesting that similar acoustical energy is transmitted to the semicircular canals and the cochlea. Since these intralabyrinthine pressures exceed intracochlear pressure levels, our results suggest that the vestibular end-organs may also be at risk for injury during exposure to high-intensity acoustic stimuli known to cause trauma in the auditory system.

  19. Proceedings of the third ICFA mini-workshop on high intensity, high brightness hadron accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Roser, T.

    1997-11-01

    The third mini-workshop on high intensity, high brightness hadron accelerators was held at Brookhaven National Laboratory on May 7-9, 1997 and had about 30 participants. The workshop focussed on rf and longitudinal dynamics issues relevant to intense and/or bright hadron synchrotrons. A plenary session was followed by four sessions on particular topics. This document contains copies of the viewgraphs used as well as summaries written by the session chairs.

  20. Proceedings of the third ICFA mini-workshop on high intensity, high brightness hadron accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Roser, T.

    1997-11-01

    The third mini-workshop on high intensity, high brightness hadron accelerators was held at Brookhaven National Laboratory on May 7-9, 1997 and had about 30 participants. The workshop focussed on rf and longitudinal dynamics issues relevant to intense and/or bright hadron synchrotrons. A plenary session was followed by four sessions on particular topics. This document contains copies of the viewgraphs used as well as summaries written by the session chairs.

  1. High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice.

    Science.gov (United States)

    Wang, Ningning; Liu, Yang; Ma, Yanan; Wen, Deliang

    2017-08-23

    Exercise is beneficial in obesity, however, the debate about the value of high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) has been long lasting. Therefore, here we have compared the possible beneficial effects of two different exercise training regimes in a mouse model of diet-induced obesity (DIO). Following 7wk. on high fat diet (HFD), ten-week-old male ICR mice (n=30) were assigned to HIIT, distance-matched MICT or remained sedentary for the next 8 constitutive weeks while maintaining the dietary treatments. Age-matched sedentary mice with standard diet were used as a control (n=10). Exercise was performed on a motorized treadmill for 5days a week. Both modes of exercise ameliorated adiposity and related metabolic dysfunction induced by HFD and sedentary lifestyle, while mice following HIIT exhibited significantly lower body weight, percentage of fat mass and smaller adipocyte size. HIIT was more favorable in preventing liver lipid accumulation by restoring mRNA levels of genes involved in hepatic lipogenesis (SREBP1, ACC1, FAS) and β-oxidation (PPARα, CPT1a, HAD). In addition, HIIT was more efficient in mitigating adipose tissue inflammation and insulin insensitivity, partly dependent on abrogating phosphorylation of JNK/IRS1 (Ser307) pathway. Moreover, only HIIT led to pronounced beige adipocyte recruitment in inguinal subcutaneous adipose tissue. We conclude that HIIT contribute a more favorable regulation of metabolic dysfunctions in DIO mice compared with MICT. Copyright © 2017. Published by Elsevier Inc.

  2. Impact of High-intensity Intermittent and Moderate-intensity Continuous Exercise on Autonomic Modulation in Young Men.

    Science.gov (United States)

    Cabral-Santos, C; Giacon, T R; Campos, E Z; Gerosa-Neto, J; Rodrigues, B; Vanderlei, L C M; Lira, F S

    2016-06-01

    The aim of this study was to compare heart rate variability (HRV) recovery after two iso-volume (5 km) exercises performed at different intensities. 14 subjects volunteered (25.17±5.08 years; 74.7±6.28 kg; 175±0.05 cm; 59.56±5.15 mL·kg(-1)·min(-1)) and after determination of peak oxygen uptake (VO2Peak) and the speed associated with VO2Peak (sVO2Peak), the subjects completed 2 random experimental trials: high-intensity exercise (HIE - 1:1 at 100% sVO2Peak), and moderate-intensity continuous exercise (MIE - 70% sVO2Peak). HRV and RR intervals were monitored before, during and after the exercise sessions together with, the HRV analysis in the frequency domains (high-frequency - HF: 0.15 to 0.4 Hz and low-frequency - LF: 0.04 to 0.15 Hz components) and the ratio between them (LF/HF). Statistical analysis comparisons between moments and between HIE and MIE were performed using a mixed model. Both exercise sessions modified LFlog, HFlog, and LF/HF (F=16.54, F=19.32 and F=5.17, p<0.05, respectively). A group effect was also found for LFlog (F=23.91, p<0.05), and HFlog (F=57.55, p< 0.05). LF/HF returned to resting value 15 min after MIE exercise and 20 min after HIE exercise. This means that the heavy domain (aerobic and anaerobic threshold) induces dissimilar autonomic modification in physically active subjects. Both HIE and MIE modify HRV, and generally HIE delays parasympathetic autonomic modulation recovery after iso-volume exercise.

  3. Pedalling rate affects endurance performance during high-intensity cycling

    DEFF Research Database (Denmark)

    Nielsen, Jens Steen; Hansen, Ernst Albin; Sjøgaard, Gisela

    2004-01-01

    , such as muscle fibre type composition and power reserve, relate to endurance time. Twenty males underwent testing to determine their maximal oxygen uptake (VO(2max)), power output corresponding to 90% of VO(2max) at 80 rpm (W90), FCPR at W90, percentage of slow twitch muscle fibres (% MHC I), maximal leg power...... time was negatively related to VO(2max), W90 and % MHC I, while positively related to power reserve. In conclusion, at group level, endurance time was longer at FCPR and at a pedalling rate 25% lower compared to a pedalling rate 25% higher than FCPR. Further, inter-individual physiological variables......The purpose of this study into high-intensity cycling was to: (1) test the hypothesis that endurance time is longest at a freely chosen pedalling rate (FCPR), compared to pedalling rates 25% lower (FCPR-25) and higher (FCPR+25) than FCPR, and (2) investigate how physiological variables...

  4. Vortex dynamics and shear layer instability in high intensity cyclotrons

    CERN Document Server

    Cerfon, Antoine J

    2016-01-01

    We show that the space charge dynamics of high intensity beams in the plane perpendicular to the magnetic field in cyclotrons is described by the two-dimensional Euler equations for an incompressible fluid. This analogy with fluid dynamics gives a unified and intuitive framework to explain the beam spiraling and beam break up behavior observed in experiments and in simulations. In particular, we demonstrate that beam break up is the result of a classical instability occurring in fluids subject to a sheared flow. We give scaling laws for the instability and predict the nonlinear evolution of beams subject to it. Our work suggests that cyclotrons may be uniquely suited for the experimental study of shear layers and vortex distributions that are not achievable in Penning-Malmberg traps.

  5. Repeated high-intensity exercise in a professional rugby league.

    Science.gov (United States)

    Austin, Damien J; Gabbett, Tim J; Jenkins, David J

    2011-07-01

    The primary aim of this study was to identify and describe the frequency and duration of repeated high-intensity exercise (RHIE) bouts in Australian professional rugby league (National Rugby League) and whether these occurred at critical times during a game. Time motion analysis was used during 5 competition matches; 1 player from 3 positional groups (hit-up forward, adjustable, and outside back) was analyzed in each match. The ranges of RHIE bouts for the 3 positional groups were hit-up forwards 9-17, adjustables 2-8, and outside backs 3-7. Hit-up forwards were involved in a significantly greater number of RHIE bouts (p rugby league players are likely to encounter.

  6. Fast damping in mismatched high intensity beam transportation

    Directory of Open Access Journals (Sweden)

    V. Variale

    2001-08-01

    Full Text Available A very fast damping of beam envelope oscillation amplitudes was recently observed in simulations of high intensity beam transport, through periodic FODO cells, in mismatched conditions [V. Variale, Nuovo Cimento Soc. Ital. Fis. 112A, 1571–1582 (1999 and T. Clauser et al., in Proceedings of the Particle Accelerator Conference, New York, 1999 (IEEE, Piscataway, NJ, 1999, p. 1779]. A Landau damping mechanism was proposed at the origin of observed effect. In this paper, to further investigate the source of this fast damping, extensive simulations have been carried out. The results presented here support the interpretation of the mechanism at the origin of the fast damping as a Landau damping effect.

  7. New Zealand Blackcurrant Extract Improves High-Intensity Intermittent Running.

    Science.gov (United States)

    Perkins, Ian Craig; Vine, Sarah Anne; Blacker, Sam David; Willems, Mark Elisabeth Theodorus

    2015-10-01

    We examined the effect of New Zealand blackcurrant (NZBC) extract on high-intensity intermittent running and postrunning lactate responses. Thirteen active males (age: 25 ± 4 yrs, height: 1.82 ± 0.07 m, body mass: 81 ± 14 kg, VO2max: 56 ± 4 ml·kg-1·min-1, vVO2max: 17.6 ± 0.8 km·h-1) performed a treadmill running protocol to exhaustion, which consisted of stages with 6 × 19 s of sprints with 15 s of low-intensity running between sprints. Interstage rest time was 1 min and stages were repeated with increasing sprint speeds. Subjects consumed capsuled NZBC extract (300 mg·day-1 CurraNZ; containing 105 mg anthocyanin) or placebo for 7 days (double-blind, randomized, crossover design, wash-out at least 14 days). Blood lactate was collected for 30 min postexhaustion. NZBC increased total running distance by 10.6% (NZBC: 4282 ± 833 m, placebo: 3871 ± 622 m, p = .02), with the distance during sprints increased by 10.8% (p = .02). Heart rate, oxygen uptake, lactate and rating of perceived exertion were not different between conditions for the first 4 stages completed by all subjects. At exhaustion, blood lactate tended to be higher for NZBC (NZBC: 6.01 ± 1.07 mmol·L-1, placebo: 5.22 ± 1.52 mmol·L-1, p = .07). There was a trend for larger changes in lactate following 15 min (NZBC: -2.89 ± 0.51 mmol·L-1, placebo: -2.46 ± 0.39 mmol·L-1, p = .07) of passive recovery. New Zealand blackcurrant extract (CurraNZ) may enhance performance in sports characterized by high-intensity intermittent exercise as greater distances were covered with repeated sprints, there was higher lactate at exhaustion, and larger changes in lactate during early recovery after repeated sprints to exhaustion.

  8. Nanobiotechnology promotes noninvasive high-intensity focused ultrasound cancer surgery.

    Science.gov (United States)

    Chen, Yu; Chen, Hangrong; Shi, Jianlin

    2015-01-07

    The successful cancer eradication in a noninvasive manner is the ultimate objective in the fight against cancer. As a "bloodless scalpel," high-intensity focused ultrasound (HIFU) is regarded as one of the most promising and representative noninvasive therapeutic modalities for cancer surgery. However, large-scale clinical applications of HIFU are still in their infancy because of critical efficiency and safety issues which remain to be solved. Fortunately, recently developed nanobiotechnology provides an alternative efficient approach to improve such important issues in HIFU, especially for cancer therapy. This Research News presents the very recent exciting progresses on the elaborate design and fabrication of organic, inorganic, and organic/inorganic hybrid nanoparticles for enhancing the HIFU ablation efficiency against tumor tissues. It is highly expected that this Research News can arouse more extensive research enthusiasm on the development of functional nanomaterials for highly efficient HIFU-based synergistic therapy, which will give a promising noninvasive therapeutic modality for the successful cancer therapy with minimal damage to surrounding normal tissues, due to the noninvasive and site-specific therapeutic features of HIFU.

  9. Bunching high intensity proton beams with a CH-DTL

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, Malte; Claessens, Christine; Heilmann, Manuel; Hinrichs, Ole; Koser, Daniel; Meusel, Oliver; Noll, Daniel; Podlech, Holger; Ratzinger, Ulrich; Seibel, Anja [Institut fuer Angewandte Physik, Goethe-Universitaet Frankfurt am Main (Germany)

    2014-07-01

    The Frankfurt Neutron Source at the Stern-Gerlach-Zentrum (FRANZ) will provide ultra short neutron pulses at high intensities and repetition rates. The facility is under construction with an expected first beam by the end of 2014. A 5-Gap CH rebuncher is installed behind a coupled RFQ/IH-DTL combination at the end of the LINAC section between two magnetic quadrupole triplets. It will be used for varying the final energy between 1.8 and 2.2 MeV, as well as for focusing the proton beam bunch longitudinally, to compensate RF defocusing effects and huge space charge forces at currents up to 200 mA at the final stage of extension. Therefore high current beam dynamic simulations are in progress. They include benchmarking of different beam dynamic codes like LORASR, TraceWin and Bender (a new PIC tracking code developed at IAP), as well as validating the results by measurements. Detailed error tolerance studies, thermal simulations and examination of multipole field impact, due to the cavity geometry, are also done. Furthermore, this CH rebuncher serves as prototype for CH cavity operation at MYRRHA (Belgium), an Accelerator Driven System (ADS) for transmutation of high level nuclear waste. After copper-plating the cavity, RF conditioning will start in spring 2014.

  10. Observation of fine particle aggregating behavior induced by high intensity conditioning using high speed CCD

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The aggregating behavior between bubbles and particles induced by high intensity conditioning (HIC) was studied using high speed CCD technique. Bubble size measurement was conducted, and the attachment behavior between bubbles and particles in HIC cell and flotation cell were observed. The results show that in HIC cell, high intensity conditioning creates an advantage environment for the formation of small size bubble due to hydrodynamic cavitations, and these fine bubbles have high probability of bubble-particle collision,which will enhance fine particle flotation. The bubble-particle attachment experiments indicate that in high intensity conditioning cell, a lot of fine bubbles are produced in situ on the surface of fine particles, and most of fine particles are aggregated under the bridging action of fine bubbles. The observation of bubble-particle interaction in flotation cell illustrates that aggregates created by HIC can be loaded more easily by big air bubble in flotation cell than those created by normal conditioning.

  11. Investigations on transport and storage of high ion beam intensities

    Energy Technology Data Exchange (ETDEWEB)

    Joshi, Ninad Shrikrishna

    2009-08-25

    In the framework of this thesis the intense low energy ion beam transport was investigated. Especially, the beam transport in toroidal magnetic field configurations was discussed, as it may allow the accumulation of high intensive beams in the future. One of the specific tasks is to design an injection system that can be used for the proposed low energy accumulator ring. A simulation code (TBT) was written to describe the particle motion in curved segments. Particle in Cell techniques were utilized to simulate a multi particle dynamics. A possibility of reading an external data file was made available so that a measured distribution can be used to compare simulation results with measured ones. A second order cloud in cell method was used to calculate charge density and in turn to solve Poisson's equation. Further simulations were performed to study the self field effects on beam transport. Experiments were performed to compare the simulation results and gain practical experience. The preparatory experiments consisted of building and characterization of the ion source in a first step. Along with the momentum spectrometer and emittance scanner the beam properties were studied. Low mass ion beams He{sup +} and mixed p, H{sup 2+}, H{sup 3+} beams were analyzed. In the second stage, beams were transported through a solenoid and the phase space distribution was measured as a function of the magnetic field for different beam energies. The phase-space as distributions measured in a first stage were simulated backward and then again forward transported through the solenoid. The simulated results were then compared with the measured distribution. The LINTRA transport program was used. The phase-space distribution was further simulated for transport experiments in a toroidal magnetic field. The transport program that was used to simulate the beam in the toroid was also used to design the injection system. The injection system with its special field configurations was

  12. High-order harmonic generation at high laser intensities beyond the tunnel regime

    CERN Document Server

    Pérez-Hernández, J A; Lewenstein, M; Zaïr, A; Roso, L

    2014-01-01

    We present studies of high-order harmonic generation (HHG) at laser intensities well above saturation. We use driving laser pulses which present a particular electron dynamics in the turn-on stage. Our results predict an increasing on the harmonic yield, after an initial dropping, when the laser intensity is increased. This fact contradicts the general belief of a progressive degradation of the harmonic emission at ultrahigh intensities. We have identified a particular set of trajectories which emerges in the turn-on stage of these singular laser pulses, responsible of the unexpected growth on the harmonic efficiency at this high intensity regime. Our study combines two complementary approaches: classical analysis and full quantum mechanical calculations resulting from the numerical integration of the 3-dimensional time-dependent Schr\\"odinger equation complemented with the time-frequency analysis.

  13. Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk.

    Science.gov (United States)

    Fleg, Jerome L

    2016-01-01

    Although moderate-intensity continuous training (MICT) has been the traditional model for aerobic exercise training for over four decades, a growing body of literature has demonstrated equal if not greater improvement in aerobic capacity and similar beneficial effects on body composition, glucose metabolism, blood pressure, and quality of life from high-intensity interval training (HIIT). An advantage of HIIT over MICT is the shorter time required to perform the same amount of energy expenditure. The current brief review summarizes the effects of HIIT on peak aerobic capacity and cardiovascular risk factors in healthy adults and those with various cardiovascular diseases, including coronary artery disease, chronic heart failure, and post heart transplantation.

  14. Echinococcus granulosus: protoscolicidal effect of high intensity focused ultrasound.

    Science.gov (United States)

    Zou, Xiaoyi; Wang, Junan; Zhao, Hailong; Zhang, Jing; Wu, Weihua; Ye, Bin

    2009-04-01

    High intensity focused ultrasound (HIFU) is a new non-invasive technique which can cause cell death and tissue necrosis by focusing high-energy ultrasonic waves on a single location. The aim of our work is to investigate the damaging effect of HIFU on Echinococcus granulosus protoscolices, as well as its inhibitory effect on growth of hydatid cysts derived from protoscolices. The damaging effect of HIFU on protoscolices was investigated by following parasite mortality after irradiation, while the inhibitory effect was investigated by infection experiments in vivo. The results demonstrated that HIFU was able to damage protoscolices and the protoscolicidal effect was dose-dependent and showed late-onset. The growth of protoscolices that survived the exposure to HIFU was obviously suppressed in vitro, and the mean weight of hydatid cysts resulting from such protoscolices in the experimental group was less than that in controls. Evidences including the protoscolicidal effect, fragmentized protoscolices and low post exposure temperatures, suggest that cavitation may contribute to the protoscolicidal effect of HIFU. In addition, the structure of the germinal membrane in cysts developing from the irradiated protoscolices was not as normal or intact as that from non-irradiated ones, and morphological changes related to degeneration were observed, suggesting that HIFU could prevent protoscolices from developing normal germinal membrane and consequently stop the proliferation of secondary hydatid cysts. HIFU demonstrated damaging effect on protoscolices, inhibited the growth of protoscolices in vitro and in vivo, and could be a possible therapeutic option for cystic echinococcosis.

  15. Interaction of High Intensity Electromagnetic Waves with Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    G. Shvets

    2008-10-03

    The focus of our work during the duration of this grant was on the following areas: (a) the fundamental plasma physics of intense laser-plasma interactions, including the nonlinear excitation of plasma waves for accelerator applications, as well as the recently discovered by us phenomenon of the relativistic bi-stability of relativistic plasma waves driven by a laser beatwave; (b) interaction of high power microwave beams with magnetized plasma, including some of the recently discovered by us phenomena such as the Undulator Induced Transparency (UIT) as well as the new approaches to dynamic manipulation of microwave pulses; (c) investigations of the multi-color laser pulse interactions in the plasma, including the recently discovered by us phenomenon of Electromagnetic Cascading (EC) and the effect of the EC of three-dimensional dynamics of laser pulses (enhanced/suppressed selffocusing etc.); (d) interaction of high-current electron beams with the ambient plasma in the context of Fast Ignitor (FI) physics, with the emphasis on the nonlinear dynamics of the Weibel instability and beam filamentation.

  16. High-intensity intermittent swimming improves cardiovascular health status for women with mild hypertension

    DEFF Research Database (Denmark)

    Mohr, Magni; Nordsborg, Nikolai Baastrup; Lindenskov, Annika;

    2014-01-01

    To test the hypothesis that high-intensity swim training improves cardiovascular health status in sedentary premenopausal women with mild hypertension, sixty-two women were randomized into high-intensity (n = 21; HIT), moderate-intensity (n = 21; MOD), and control groups (n = 20; CON). HIT...... high-intensity intermittent swimming is an effective training strategy to improve cardiovascular health and physical performance...... in sedentary women with mild hypertension. Adaptations are similar with high- and moderate-intensity training, despite markedly less total time spent and distance covered in the high-intensity group....

  17. Effects of high-intensity interval training on the VO2 response during severe exercise.

    Science.gov (United States)

    Duffield, Rob; Edge, Johann; Bishop, David

    2006-06-01

    This study examined the effect of high-intensity interval training on the VO2 response during severe, constant-load exercise. Prior to, and following training, 10 females (V O2 peak 37.4+/-6.0 mL kg-1 min-1) performed a graded exercise test to determine VO2 peak and lactate threshold (LT) and a 6 min cycle test (CT) at the pre-training VO2 peak intensity. Training involved high-intensity intervals (2 min work, 1 min rest) performed 3x week for 8 weeks. Breath-by-breath data from 0 to 6 min during the CT were smoothed using 5s averages and fit to a bi-exponential model starting from 20s. Training resulted in significant improvements in VO2 max (2.34+/-0.37-2.78+/-0.30 L min-1), power at VO2 max (170+/-26-204+/-25 W) and power at LT (113+/-17-136+/-20 W) (pVO2 response showed a significant increase in the amplitude of the primary phase (A1) (1396+/-103-1695+/-100 mL min-1; pVO2 (VO2 EE), with no difference (p>0.05) in the time constants of either phase or the amplitude of the slow component (318+/-67-380+/-48 mL; p=0.15). In conjunction, accumulated oxygen deficit (AOD) (43.7+/-9.8-17.2+/-2.8 mL O2 eq kg-1) and anaerobic contribution to the CT (19.4+/-4.4-7.2+/-1.2%) were significantly reduced. In contrast to previous moderate-intensity research, a high-intensity interval training program increased A1 and VO2 EE for the same absolute exercise intensity, decreasing the AOD during a severe-intensity CT.

  18. A Warm Fluid Model of Intense Laser-Plasma Interactions

    Science.gov (United States)

    Tarkenton, G. M.; Shadwick, B. A.; Esarey, E. H.; Leemans, W. P.

    2001-10-01

    Following up on our previous work on modeling intense laser-plasma interactions with cold fluids,(B.A.Shadwick, G. M. Tarkenton, E.H. Esarey, and W.P. Leemans, ``Fluid Modeling of Intense Laser-Plasma Interactions'', in Advanced Accelerator Concepts), P. Colestock and S. Kelley editors, AIP Conf. Proc. 569 (AIP, NY 2001), pg. 154. we are exploring warm fluid models. These models represent the next level in a hierarchy of complexity beyond the cold fluid approximation. With only a modest increase in computation effort, warm fluids incorporate effects that are relevant to a variety of technologically interesting cases. We present a derivation of the warm fluid from a kinetic (i.e. Vlasov) perspective and make a connection with the usual relativistic thermodynamic approach.(S. R. de Groot, W. A. van Leeuwen and Ch. G. van Weert, Relativistic Kinetic Theory: Principles and Applications), North-Holland (1980). We will provide examples where the warm fluids yield physics results not contained in the cold model and discuss experimental parameters where these effects are believed to be important.

  19. Creatine kinase response to high-intensity aerobic exercise in adult-onset muscular dystrophy

    DEFF Research Database (Denmark)

    Andersen, Søren P; Sveen, Marie-Louise; Hansen, Regitze S

    2013-01-01

    We investigated the effect of high-intensity exercise on plasma creatine kinase (CK) in patients with muscular dystrophies.......We investigated the effect of high-intensity exercise on plasma creatine kinase (CK) in patients with muscular dystrophies....

  20. Compliance with High-Intensity Radiated Fields Regulations - Emitter's Perspective

    Science.gov (United States)

    Statman, Joseph; Jamnejad, Vahraz; Nguyen, Lee

    2012-01-01

    NASA's Deep Space Network (DSN) uses high-power transmitters on its large antennas to communicate with spacecraft of NASA and its partner agencies. The prime reflectors of the DSN antennas are parabolic, at 34m and 70m in diameter. The DSN transmitters radiate Continuous Wave (CW) signals at 20 kW - 500 kW at X-band and S-band frequencies. The combination of antenna reflector size and high frequency results in a very narrow beam with extensive oscillating near-field pattern. Another unique feature of the DSN antennas is that they (and the radiated beam) move mostly at very slow sidereal rate, essentially identical in magnitude and at the opposite direction of Earth rotation.The DSN is in the process of revamping its documentation to provide analysis of the High Intensity Radiation Fields (HIRF) environment resulting from radio frequency radiation from DSN antennas for comparison to FAA regulations regarding certification of HIRF protection as outlined in the FAA regulations on HIRF protection for aircraft electrical and electronic systems (Title 14, Code of Federal Regulations (14 CFR) [section sign][section sign] 23.1308, 25.1317, 27.1317, and 29.1317).This paper presents work done at JPL, in consultation with the FAA. The work includes analysis of the radiated field structure created by the unique DSN emitters (combination of transmitters and antennas) and comparing it to the fields defined in the environments in the FAA regulations. The paper identifies areas that required special attention, including the implications of the very narrow beam of the DSN emitters and the sidereal rate motion. The paper derives the maximum emitter power allowed without mitigation and the mitigation zones, where required.Finally, the paper presents summary of the results of the analyses of the DSN emitters and the resulting DSN process documentation.

  1. Distributed modelling of shallow landslides triggered by intense rainfall

    Directory of Open Access Journals (Sweden)

    G. B. Crosta

    2003-01-01

    Full Text Available Hazard assessment of shallow landslides represents an important aspect of land management in mountainous areas. Among all the methods proposed in the literature, physically based methods are the only ones that explicitly includes the dynamic factors that control landslide triggering (rainfall pattern, land-use. For this reason, they allow forecasting both the temporal and the spatial distribution of shallow landslides. Physically based methods for shallow landslides are based on the coupling of the infinite slope stability analysis with hydrological models. Three different grid-based distributed hydrological models are presented in this paper: a steady state model, a transient "piston-flow" wetting front model, and a transient diffusive model. A comparative test of these models was performed to simulate landslide occurred during a rainfall event (27–28 June 1997 that triggered hundreds of shallow landslides within Lecco province (central Southern Alps, Italy. In order to test the potential for a completely distributed model for rainfall-triggered landslides, radar detected rainfall intensity has been used. A new procedure for quantitative evaluation of distributed model performance is presented and used in this paper. The diffusive model results in the best model for the simulation of shallow landslide triggering after a rainfall event like the one that we have analysed. Finally, radar data available for the June 1997 event permitted greatly improving the simulation. In particular, radar data allowed to explain the non-uniform distribution of landslides within the study area.

  2. An intensity-based stochastic model for terrestrial laser scanners

    Science.gov (United States)

    Wujanz, D.; Burger, M.; Mettenleiter, M.; Neitzel, F.

    2017-03-01

    Up until now no appropriate models have been proposed that are capable to describe the stochastic characteristics of reflectorless rangefinders - the key component of terrestrial laser scanners. This state has to be rated as unsatisfactory especially from the perception of Geodesy where comprehensive knowledge about the precision of measurements is of vital importance, for instance to weigh individual observations or to reveal outliers. In order to tackle this problem, a novel intensity-based stochastic model for the reflectorless rangefinder of a Zoller + Fröhlich Imager 5006 h is experimentally derived. This model accommodates the influence of the interaction between the emitted signal and object surface as well as the acquisition configuration on distance measurements. Based on two different experiments the stochastic model has been successfully verified for three chosen sampling rates.

  3. A Clinic Model: Post-Intensive Care Syndrome and Post-Intensive Care Syndrome-Family.

    Science.gov (United States)

    Huggins, Elizabeth L; Bloom, Sarah L; Stollings, Joanna L; Camp, Mildred; Sevin, Carla M; Jackson, James C

    2016-01-01

    The number of patients surviving critical illness in the United States has increased with advancements in medicine. Post-intensive care syndrome and post-intensive care syndrome-family are terms developed by the Society of Critical Care Medicine in order to address the cognitive, psychological, and physical sequelae emerging in patients and their families after discharge from the intensive care unit. In the United Kingdom and Europe, intensive care unit follow-up clinics have been used to address the complications of post-intensive care syndrome for some time. However, the interprofessional clinic at Vanderbilt University Medical Center is among the first in the United States to address the wide variety of problems experienced by intensive care survivors and to provide patients and their families with care after discharge from the intensive care unit.

  4. High-intensity interval training vs. moderate-intensity continuous training in the prevention/management of cardiovascular disease

    OpenAIRE

    S Hussain; Macaluso, A; Pearson, S.

    2016-01-01

    Moderate-intensity continuous training (MICT) has long been considered the most effective exercise treatment modality for the prevention and management of cardiovascular disease, but more recently high-intensity interval training (HIIT) has emerged into the clinical environment has been viewed as a potential alternative to MICT in accruing such benefits. HIIT was initially found to induce significant improvements in numerous physiological and health-related indices, to a similar if not superi...

  5. A review of adolescent high-intensity interval training.

    Science.gov (United States)

    Logan, Greig R M; Harris, Nigel; Duncan, Scott; Schofield, Grant

    2014-08-01

    Despite the promising evidence supporting positive effects of high-intensity interval training (HIIT) on the metabolic profile in adults, there is limited research targeting adolescents. Given the rising burden of chronic disease, it is essential to implement strategies to improve the cardiometabolic health in adolescence, as this is a key stage in the development of healthy lifestyle behaviours. This narrative review summarises evidence of the relative efficacy of HIIT regarding the metabolic health of adolescents. Methodological inconsistencies confound our ability to draw conclusions; however, there is meaningful evidence supporting HIIT as a potentially efficacious exercise modality for use in the adolescent cohort. Future research must examine the effects of various HIIT protocols to determine the optimum strategy to deliver cardiometabolic health benefits. Researchers should explicitly show between-group differences for HIIT intervention and steady-state exercise or control groups, as the magnitude of difference between HIIT and other exercise modalities is of key interest to public health. There is scope for research to examine the palatability of HIIT as an exercise modality for adolescents through investigating perceived enjoyment during and after HIIT, and consequent long-term exercise adherence.

  6. Treatment of glaucoma with high intensity focused ultrasound.

    Science.gov (United States)

    Aptel, Florent; Lafon, Cyril

    2015-05-01

    Glaucoma is a common disease mainly due to an increase in pressure inside the eye, leading to a progressive destruction of the optic nerve, potentially to blindness. Intraocular pressure (IOP) is the result of a balance between production of liquid that fills the eye--aqueous humour--and its resorption. All treatments for glaucoma aim to reduce IOP and can therefore have two mechanisms of action: reducing aqueous humour production by the partial destruction or medical inhibition of the ciliary body--the anatomical structure responsible for production of aqueous humour--or facilitating the evacuation of aqueous humour from the eye. Several physical methods can be used to destroy the ciliary body, e.g. laser, cryotherapy, microwave. All these methods have two major drawbacks: they are non-selective for the organ to be treated and they have an unpredictable dose–effect relationship. High intensity focused ultrasound (HIFU) can be used to coagulate the ciliary body and avoid these drawbacks. A commercially available device was marketed in the 1980s, but later abandoned, essentially for technical reasons. A smaller circular device using miniaturised transducers was recently developed and proposed for clinical practice. Experimental studies have shown selective coagulation necrosis of the treated ciliary body. The first three clinical trials in humans have shown that this device was well tolerated and allowed a significant, predictable and sustained reduction of IOP. The aim of this contribution is to present a summary of the work concerning the use of HIFU to treat glaucoma.

  7. Robotic Assisted Laparoscopic Prostatectomy after High Intensity Focused Ultrasound Failure

    Directory of Open Access Journals (Sweden)

    Leon Telis

    2017-01-01

    Full Text Available Background. Prostate cancer is the most common cancer diagnosed in men. As new focal therapies become more popular in treatment of prostate cancer, failure cases requiring salvage therapy with either surgical or other techniques are being reported. Objective. To report the options in treatment of prostate cancer after recurrence or failure of the primary treatment modality. Methods. We report a salvage robotic assisted laparoscopic radical prostatectomy (RALP for prostate cancer recurrence following high intensity focused ultrasound treatment (HIFU in the United States. Results. A 67-year-old man who underwent HIFU treatment for prostate adenocarcinoma 2 years prior was presented with a rising prostate specific antigen of 6.1 ng/mL to our clinic. A biopsy proven recurrent disease in the area of previous treatment documented the failure of treatment. The patient elected to undergo a salvage RALP. The operation time was 159 minutes. The patient was discharged from the hospital on postoperative day 1 with no complications. The catheter was removed on post-op day 10. The patient reserved sexual function and urinary continence. The PSA levels on 6 months’ follow-up are undetectable. Conclusions. Salvage RALP is an effective and safe treatment choice for recurrent prostate adenocarcinoma following failed HIFU treatment if operated by an experienced surgeon.

  8. Inelastic scattering in condensed matter with high intensity Moessbauer radiation

    Energy Technology Data Exchange (ETDEWEB)

    Yelon, W.B.; Schupp, G.

    1990-10-01

    We give a progress report for the work which has been carried out in the last three years with DOE support. A facility for high-intensity Moessbauer scattering is now fully operational at the University of Missouri Research Reactor (MURR) as well as facility at Purdue, using special isotopes produced at MURR. High precision, fundamental Moessbauer effect studies have been carried out using scattering to filter the unwanted radiation. These have led to a new Fourier transform method for describing Moessbauer effect (ME) lineshape and a direct method of fitting ME data to the convolution integral. These methods allow complete correction for source resonance self absorption (SRSA) and the accurate representation of interference effects that add an asymmetric component to the ME lines. We have begun applying these techniques to attenuated ME sources whose central peak has been attenuated by stationary resonant absorbers, to more precisely determine interference parameters and line-shape behavior in the resonance asymptotic region. This analysis is important to both the fundamental ME studies and to scattering studies for which a deconvolution is essential for extracting the correct recoilless fractions and interference parameters. A number of scattering studies have been successfully carried out including a study of the thermal diffuse scattering in Si, which led to an analysis of the resolution function for gamma-ray scattering. Also studied was the anharmonic motion in Na and the satellite reflection Debye-Waller factor in TaS{sub 2}, which indicate phason rather than phonon behavior. We have begun quasielastic diffusion studies in viscous liquids and current results are summarized. These advances, coupled to our improvements in MIcrofoil Conversion Electron spectroscopy lay the foundation for the proposed research outlined in this request for a three-year renewal of DOE support.

  9. Gamma scattering in condensed matter with high intensity Moessbauer radiation

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    We give a progress report for the work which has been carried out in the last three years with DOE support. A facility for high-intensity Moessbauer scattering is now fully operational at the University of Missouri Research Reactor (MURR) as well as a facility at Purdue, using special isotopes produced at MURR. High precision, fundamental Moessbauer effect studies have been carried out using scattering to filter the unwanted radiation. These have led to a new Fourier transform method for describing Moessbauer effect (ME) lineshape and a direct method of fitting ME data to the convolution integral. These methods allow complete correction for source resonance self absorption (SRSA) and the accurate representation of interference effects that add an asymmetric component to the ME lines. We have begun applying these techniques to attenuated ME sources whose central peak has been attenuated by stationary resonant absorbers, to more precisely determine interference parameters and line-shape behavior in the resonance asymptotic region. This analysis is important to both the fundamental ME studies and to scattering studies for which a deconvolution is essential for extracting the correct recoilless fractions and interference parameters. A number of scattering studies have been successfully carried out including a study of the thermal diffuse scattering in Si, which led to an analysis of the resolution function for gamma-ray scattering. Also studied was the anharmonic motion in Na and the satellite reflection Debye-Waller factor in TaS{sub 2}, which indicate phason rather than phonon behavior. We have begun quasielastic diffusion studies in viscous liquids and current results are summarized. These advances, coupled to our improvements in MIcrofoil Conversion Electron spectroscopy lay the foundation for the proposed research outlined in this request for a three-year renewal of DOE support.

  10. High intensity ultrasound transducer used in gene transfection

    Science.gov (United States)

    Morrison, Kyle P.; Keilman, George W.; Noble, Misty L.; Brayman, Andrew A.; Miao, Carol H.

    2012-11-01

    This paper describes a novel therapeutic high intensity non-focused ultrasound (HIU) transducer designed with uniform pressure distribution to aid in accelerated gene transfer in large animal liver tissues in vivo. The underlying HIU transducer was used to initiate homogeneous cavitation throughout the tissue while delivering up to 2.7 MPa at 1.1 MHz across its radiating surface. The HIU transducer was built into a 6 cm diameter x 1.3 cm tall housing ergonomically designed to avoid collateral damage to the surrounding anatomy during dynamic motion. The ultrasound (US) radiation was applied in a 'paintbrush-like' manner to the surface of the liver. The layers and geometry of the transducer were carefully selected to maximize the active diameter (5.74 cm), maximize the electrical to acoustic conversion efficiency (85%) to achieve 2.7 MPa of peak negative pressure, maximize the frequency operating band at the fundamental resonance to within a power transfer delta of 1 dB, and reduce the pressure delta to within 2 dB across the radiating surface. For maximum peak voltage into the transducer, a high performance piezoceramic was chosen and a DC bias circuit was built integral to the system. An apodized two element annular pattern was made from a single piezoceramic element, resulting in significant pressure uniformity enhancement. In addition to using apodization for pressure uniformity, a proprietary multi-layered structure was used to improve efficiency while sustaining an operating band from 900 kHz to 1.3 MHz. The resultant operating band allowed for dithering techniques using frequency modulation. The underlying HIU transducer for use in large animals enhances gene expression up to 6300-fold.

  11. HIGH-INTENSITY FOCUSED ULTRASOUND CASTRATION FOR BREAST CANCER PATIENTS

    Institute of Scientific and Technical Information of China (English)

    王书文; 和新盈; 石景森; 赵东利; 李明众; 王诚; 薛文华

    2003-01-01

    Objective: To evaluate the safety and efficacy of external high-intensity focused ultrasound(HIFU) castration for breast cancerous patients after mastectomy if they are at a high risk of recurrence. Methods: We recruited 52 consecutive patients with primary operable breast cancer who were treated with mastectomy with excision of regional lymph nodes. Patients were positive for ER and PR immuno- cytochemical staining, node-positive, un-menopause, over 40 years old and were divided into two groups randomly. For castration, 26 patients received one or two times of HIFU treatment within five days, and the other patients received radiotherapy with DT 18Gy/9 f/11days. During and after the treatment, local changes and systemic response of the patients were observed. Results: After 1 month treatment, levels of serum E1 and E2 were significantly decreased compared to before treatment in HIFU groups (P<0.01 and P<0.001). The same changes were occurred in radiotherapy(RT) groups (P<0.05 and P<0.01). The levels of serum E1 or E2 in RT groups were higher than in HIFU groups (P<0.05). The symptom distribution of 'climacteric syndrome' of HIFU groups were significantly different from RT groups (P<0.01). The follow-up time was 4 months. The incidence of amenorrhea was 100% in all patients. No serious complications were seen. The temperature, pulse, blood pressure, and respiratory rate of the patients were almost normal. Conclusion: We have shown that the use of HIFU in the castrating of patients with breast cancer is feasible, safe and effective. This technology may provide a rapid noninvasive alterative to conventional bilateral oophorectomy or RT castration.

  12. Backcoupling of acoustic streaming on the temperature field inside high-intensity discharge lamps

    CERN Document Server

    Schwieger, Joerg; Wolff, Marcus; Manders, Freddy; Suijker, Jos

    2015-01-01

    Operating high-intensity discharge lamps in the high frequency range (20-300 kHz) provides energy-saving and cost reduction potentials. However, commercially available lamp drivers do not make use of this operating strategy because light intensity fluctuations and even lamp destruction are possible. The reason for the fluctuating discharge arc are acoustic resonances in this frequency range that are excited in the arc tube. The acoustic resonances in turn generate a fluid flow that is caused by the acoustic streaming effect. Here, we present a 3D multiphysics model to determine the influence of acoustic streaming on the temperature field in the vicinity of an acoustic eigenfrequency. In that case a transition from stable to instable behavior occurs. The model is able to predict when light flicker can be expected. The results are in very good accordance with accompanying experiments.

  13. High Intensity Interval Training Leads to Greater Improvements in Acute Heart Rate Recovery and Anaerobic Power as High Volume Low Intensity Training

    Directory of Open Access Journals (Sweden)

    Thomas L. Stöggl

    2017-08-01

    Full Text Available The purpose of the current study was to explore if training regimes utilizing diverse training intensity distributions result in different responses on neuromuscular status, anaerobic capacity/power and acute heart rate recovery (HRR in well-trained endurance athletes.Methods: Thirty-six male (n = 33 and female (n = 3 runners, cyclists, triathletes and cross-country skiers [peak oxygen uptake: (VO2peak: 61.9 ± 8.0 mL·kg−1·min−1] were randomly assigned to one of three groups (blocked high intensity interval training HIIT; polarized training POL; high volume low intensity oriented control group CG/HVLIT applying no HIIT. A maximal anaerobic running/cycling test (MART/MACT was performed prior to and following a 9-week training period.Results: Only the HIIT group achieved improvements in peak power/velocity (+6.4%, P < 0.001 and peak lactate (P = 0.001 during the MART/MACT, while, unexpectedly, in none of the groups the performance at the established lactate concentrations (4, 6, 10 mmol·L−1 was changed (P > 0.05. Acute HRR was improved in HIIT (11.2%, P = 0.002 and POL (7.9%, P = 0.023 with no change in the HVLIT oriented control group.Conclusion: Only a training regime that includes a significant amount of HIIT improves the neuromuscular status, anaerobic power and the acute HRR in well-trained endurance athletes. A training regime that followed more a low and moderate intensity oriented model (CG/HVLIT had no effect on any performance or HRR outcomes.

  14. Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

    OpenAIRE

    Cui, Huizhong; Zhang, Ti; Yang, Xinmai

    2013-01-01

    Laser-enhanced cavitation during high intensity focused ultrasound (HIFU) was studied in vivo using a small animal model. Laser light was employed to illuminate the sample concurrently with HIFU radiation. The resulting cavitation was detected with a passive cavitation detector. The in vivo measurements were made under different combinations of HIFU treatment depths, laser wavelengths, and HIFU durations. The results demonstrated that concurrent light illumination during HIFU has the potentia...

  15. Beam Dynamics Studies for High-Intensity Beams in the CERN Proton Synchrotron

    CERN Document Server

    AUTHOR|(CDS)2082016; Benedikt, Michael

    With the discovery of the Higgs boson, the existence of the last missing piece of the Standard Model of particle physics (SM) was confirmed. However, even though very elegant, this theory is unable to explain, for example, the generation of neutrino masses, nor does it account for dark energy or dark matter. To shed light on some of these open questions, research in fundamental particle physics pursues two complimentary approaches. On the one hand, particle colliders working at the high-energy frontier, such as the Large Hadron Collider (LHC) at the European Organization for Nuclear Research (CERN), located in Geneva, Switzerland, are utilized to investigate the fundamental laws of nature. Alternatively, fixed target facilities require high-intensity beams to create a large flux of secondary particles to investigate, for example, rare particle decay processes, or to create neutrino beams. This thesis investigates limitations arising during the acceleration of high-intensity beams at the CERN Proton Synchrotro...

  16. Design and construction of a reverberation chamber for high-intensity acoustic testing.

    Science.gov (United States)

    Slusser, R. A.

    1973-01-01

    A high-intensity acoustic test facility was constructed at the Jet Propulsion Laboratory (JPL) to support the Mariner Mars 1971 project. For ease of construction, the reverberation chamber itself is rectangular, which resulted in very little sacrifice in acoustic performance. Levels as high as 156 dB can be achieved with the chamber empty and test levels of 150 dB have been used with a Mariner Mars spacecraft model (full size) in the chamber. Levels as high as this must be generated using electropneumatic transducers, which modulate gaseous nitrogen to this facility.

  17. Tools and techniques for estimating high intensity RF effects

    Science.gov (United States)

    Zacharias, Richard L.; Pennock, Steve T.; Poggio, Andrew J.; Ray, Scott L.

    1992-01-01

    Tools and techniques for estimating and measuring coupling and component disturbance for avionics and electronic controls are described. A finite-difference-time-domain (FD-TD) modeling code, TSAR, used to predict coupling is described. This code can quickly generate a mesh model to represent the test object. Some recent applications as well as the advantages and limitations of using such a code are described. Facilities and techniques for making low-power coupling measurements and for making direct injection test measurements of device disturbance are also described. Some scaling laws for coupling and device effects are presented. A method for extrapolating these low-power test results to high-power full-system effects are presented.

  18. Joint Cooling does not Hinder Athletic Performance during High-intensity Intermittent Exercise.

    Science.gov (United States)

    Kim, H; Lee, D; Choi, H-M; Park, J

    2016-07-01

    We examined the effects of ankle and knee joint cooling on 20-m sprint times and maximal vertical jump heights during high-intensity intermittent exercise. 21 healthy collegiate male basketball (n=14) and handball players (n=7) underwent 3 experimental sessions. Each session consisted of four 15-min quarters of high-intensity intermittent exercises including various intensities of 20-m shuttle running and jumping. A 20-min bilateral joint cooling (ankle, knee, or control-no cooling: in a counterbalanced order) was applied before quarters 1 and 3. After joint cooling, no warm-up activity other than the exercise protocol was given. The 20-m sprint times and maximal vertical jump heights in each experimental session were recorded at baseline (prior to quarter-1) and during each quarter. To test joint cooling effects over time, we performed 3×5 mixed model ANOVAs. Neither ankle nor knee joint cooling changed 20-m sprint times (F8,280=1.45; p=0.18) or maximal vertical jump heights (F8,280=0.76; p=0.64). However, a trend was observed in which joint cooling immediately decreased (quarters 1 and 3) but active warm-up for approximately 20 min improved 20-min sprint times (quarters 2 and 4). Our study suggests that athletic performance such as sprinting and jumping are not altered by joint cooling applied prior to or during high-intensity intermittent exercise.

  19. WE-EF-BRA-12: Magnetic Resonance- Guided High-Intensity Focused Ultrasound for Localized Ablation of Head and Neck Tissue Structures: A Feasibility Study in An Animal Model

    Energy Technology Data Exchange (ETDEWEB)

    Partanen, A [Philips Healthcare, Andover, Massachusets (United States); Ellens, N; Noureldine, S; Tufano, R [Johns Hopkins University School of Medicine, Baltimore, MD (United States); Burdette, E [Acoustic MedSystems Inc., Savoy, IL (United States); Farahani, K [National Cancer Institute, Bethesda, MD (United States)

    2015-06-15

    Purpose: High-intensity focused ultrasound (HIFU) ablation is feasible in the head and neck [1]. This study aims to expand upon these findings to assess the feasibility of treatment planning and monitoring via magnetic resonance imaging (MRI) guidance using a clinical MR-guided HIFU platform. Methods: Two 31 kg pigs were anaesthetized, shaved, and positioned prone on the HIFU table (Sonalleve, Philips Healthcare, Vantaa, Finland). The necks were acoustically coupled to the integrated transducer using gel pads and degassed water. MR imaging verified acoustic coupling and facilitated target selection in the thyroid and thymus. Targets were thermally ablated with 130–200 W of acoustic power over a period of 16 s at a frequency of 1.2 MHz while being monitored through real-time, multi-planar MR-thermometry. Contrast-enhanced MR imaging was used to assess treatment efficacy. Post-treatment, animals were euthanized and sonicated tissues were harvested for histology assessment. Results: MR-thermometry, post-contrast-imaging, and gross pathology demonstrated that the system was capable of causing localized thermal ablation in both the thyroid and the thymus without damaging the aerodigestive tract. In one animal, superficial bruising was observed in the ultrasound beam path. Otherwise, there were no adverse events. Analysis of the tissue histology found regions of damage consistent with acute thermal injury at the targeted locations. Conclusion: It is feasible to use a clinical MR-guided HIFU platform for extracorporeal ablation of porcine head and neck tissues. MR guidance and thermometry are sufficient to target and monitor treatment in the thyroid region, despite the presence of the inhomogeneous aerodigestive tract. Further study is necessary to assess efficacy and survival using a tumor model, and to examine what modifications should be made to the transducer positioning system and associated patient positioning aids to adapt it for clinical head and neck targets

  20. Advanced approaches to high intensity laser-driven ion acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Henig, Andreas

    2010-04-26

    Since the pioneering work that was carried out 10 years ago, the generation of highly energetic ion beams from laser-plasma interactions has been investigated in much detail in the regime of target normal sheath acceleration (TNSA). Creation of ion beams with small longitudinal and transverse emittance and energies extending up to tens of MeV fueled visions of compact, laser-driven ion sources for applications such as ion beam therapy of tumors or fast ignition inertial con finement fusion. However, new pathways are of crucial importance to push the current limits of laser-generated ion beams further towards parameters necessary for those applications. The presented PhD work was intended to develop and explore advanced approaches to high intensity laser-driven ion acceleration that reach beyond TNSA. In this spirit, ion acceleration from two novel target systems was investigated, namely mass-limited microspheres and nm-thin, free-standing diamond-like carbon (DLC) foils. Using such ultrathin foils, a new regime of ion acceleration was found where the laser transfers energy to all electrons located within the focal volume. While for TNSA the accelerating electric field is stationary and ion acceleration is spatially separated from laser absorption into electrons, now a localized longitudinal field enhancement is present that co-propagates with the ions as the accompanying laser pulse pushes the electrons forward. Unprecedented maximum ion energies were obtained, reaching beyond 0.5 GeV for carbon C{sup 6+} and thus exceeding previous TNSA results by about one order of magnitude. When changing the laser polarization to circular, electron heating and expansion were shown to be efficiently suppressed, resulting for the first time in a phase-stable acceleration that is dominated by the laser radiation pressure which led to the observation of a peaked C{sup 6+} spectrum. Compared to quasi-monoenergetic ion beam generation within the TNSA regime, a more than 40 times

  1. High-Intensity Training and Salivary Immunoglobulin A Responses in Professional Top-Level Soccer Players: Effect of Training Intensity.

    Science.gov (United States)

    Owen, Adam L; Wong, Del P; Dunlop, Gordon; Groussard, Carole; Kebsi, Wiem; Dellal, Alexandre; Morgans, Ryland; Zouhal, Hassane

    2016-09-01

    Owen, AL, Wong, DP, Dunlop, G, Groussard, C, Kebsi, W, Dellal, A, Morgans, R, and Zouhal, H. High-intensity training and salivary immunoglobulin A responses in professional top-level soccer players: Effect of training intensity. J Strength Cond Res 30(9): 2460-2469, 2016-This study aimed (a) to test the hypothesis that salivary immunoglobulin A (s-IgA) would vary with training intensity sessions (low-intensity [LI] vs. high-intensity sessions [HI]) during a traditional training program divided into 4 training periods and (b) to identify key variables (e.g., GPS data, rating of perceived exertion [RPE], and training duration), which could affect s-IgA. Saliva samples of 10 elite professional soccer players were collected (a) before the investigation started to establish the baseline level and (b) before and after each 4 training sessions (LI vs. HI). Training intensity was monitored as internal (through heart rate responses and RPE) and external (through GPS) loads. High-intensity sessions were associated with higher external load (GPS) and with higher RPE. Baseline and pretraining s-IgA did not differ between the 4 training sessions both for HI and LI. Post-training s-IgA were not different (in absolute value and in percentage of change) between HI and LI sessions at the first 3 periods. However, at the fourth period, s-IgA concentration for HI session was significantly lower (p ≤ 0.05) than the LI session. The percentage change between s-IgA post-training and s-IgA baseline concentrations differ significantly (p ≤ 0.05) between HI and LI training sessions. Significant correlations between s-IgA and training intensity were also noted. High-intensity soccer training sessions might cause a significant decrease in s-IgA values during the postexercise window as compared with LI sessions. This study encourages coaches to monitor s-IgA in routine, particularly during HI training periods, to take precautions to avoid upper respiratory tract infection in highly trained

  2. High-intensity intermittent swimming improves cardiovascular health status for women with mild hypertension

    DEFF Research Database (Denmark)

    Mohr, Magni; Nordsborg, Nikolai Baastrup; Lindenskov, Annika

    2014-01-01

    To test the hypothesis that high-intensity swim training improves cardiovascular health status in sedentary premenopausal women with mild hypertension, sixty-two women were randomized into high-intensity (n = 21; HIT), moderate-intensity (n = 21; MOD), and control groups (n = 20; CON). HIT perfor...

  3. High-Intensity Femtosecond Laser Interaction with Rare Gas Clusters

    Institute of Scientific and Technical Information of China (English)

    林亚风; 钟钦; 曾淳; 陈哲

    2001-01-01

    With a 45 fs multiterawatt 790 nm laser system and jets of argon and krypton atomic clusters, a study of the interaction of fs intense laser pulses with large size rare gas dusters was conducted. The maximum laser intensity of about 7 × 1016 W/cm2 and dusters composed of thousands of atoms which were determined through Rayleigh scattering measurements were involved inthe experiments. On the one hand, the results indicate that the interaction is strongly cluster size dependent. The stronger the interaction, the larger the clusters are. On the other hand, a saturation followed by a drop of the energy of ions ejected from the interaction will occur when the laser intensity exceeds a definite value for clusters of a certain size.

  4. The High Luminosity Challenge: potential and limitations of High Intensity High Brightness in the LHC and its injectors

    CERN Document Server

    De Maria, R; Banfi, D; Barranco, J; Bartosik, H; Benedetto, E; Bruce, R; Brüning, O; Calaga, R; Cerutti, F; Damerau, H; Esposito, L; Fartoukh, S; Fitterer, M; Garoby, R; Gilardoni, S; Giovannozzi, M; Goddard, B; Gorini, B; Hanke, K; Iadarola, G; Lamont, M; Meddahi, M; Métral, E; Mikulec, B; Mounet, N; Papaphilippou, Y; Pieloni, T; Redaelli, S; Rossi, L; Rumolo, G; Shaposhnikova, E; Sterbini, G; Todesco, E; Tomás, R; Zimmermann, F; Valishev, A

    2014-01-01

    High-intensity and high-brightness beams are key ingredients to maximize the LHC integrated luminosity and to exploit its full potential. This contribution describes the optimization of beam and machine parameters to maximize the integrated luminosity as seen by the LHC experiments, by taking into account the expected intensity and brightness reach of LHC itself and its injector chain as well as the capabilities of the detectors for next run and foreseen upgrade scenarios.

  5. Comparison of Dst Forecast Models for Intense Geomagnetic Storms

    Science.gov (United States)

    Ji, Eun-Young; Moon, Y.-J.; Gopalswamy, N.; Lee, D.-H.

    2012-01-01

    We have compared six disturbance storm time (Dst) forecast models using 63 intense geomagnetic storms (Dst Dst data and the predicted Dst during the geomagnetic storm period as well as the difference of the value of minimum Dst (Delta Dst(sub min)) and the difference in the absolute value of Dst minimum time (Delta t(sub Dst)) between the observed and the predicted. As a result, we found that the model by Temerin and Li gives the best prediction for all parameters when all 63 events are considered. The model gives the average values: the linear correlation coefficient of 0.94, the RMS error of 14.8 nT, the Delta Dst(sub min) of 7.7 nT, and the absolute value of Delta t(sub Dst) of 1.5 hour. For further comparison, we classified the storm events into two groups according to the magnitude of Dst. We found that the model of Temerin and Lee is better than the other models for the events having 100 Dst Dst <= 200 nT.

  6. H- Ion Sources for High Intensity Proton Drivers

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Rolland Paul; Dudnikov, Vadim

    2015-02-20

    Existing RF Surface Plasma Sources (SPS) for accelerators have specific efficiencies for H+ and H- ion generation around 3 to 5 mA/cm2 per kW, where about 50 kW of RF power is typically needed for 50 mA beam current production. The Saddle Antenna (SA) SPS described here was developed to improve H- ion production efficiency, reliability and availability for pulsed operation as used in the ORNL Spallation Neutron Source . At low RF power, the efficiency of positive ion generation in the plasma has been improved to 200 mA/cm2 per kW of RF power at 13.56 MHz. Initial cesiation of the SPS was performed by heating cesium chromate cartridges by discharge as was done in the very first versions of the SPS. A small oven to decompose cesium compounds and alloys was developed and tested. After cesiation, the current of negative ions to the collector was increased from 1 mA to 10 mA with RF power 1.5 kW in the plasma (6 mm diameter emission aperture) and up to 30 mA with 4 kW RF power in the plasma and 250 Gauss longitudinal magnetic field. The ratio of electron current to negative ion current was improved from 30 to 2. Stable generation of H- beam without intensity degradation was demonstrated in the aluminum nitride (AlN) discharge chamber for 32 days at high discharge power in an RF SPS with an external antenna. Some modifications were made to improve the cooling and cesiation stability. The extracted collector current can be increased significantly by optimizing the longitudinal magnetic field in the discharge chamber. While this project demonstrated the advantages of the pulsed version of the SA RF SPS as an upgrade to the ORNL Spallation Neutron Source, it led to a possibility for upgrades to CW machines like the many cyclotrons used for commercial applications. Four appendices contain important details of the work carried out under this grant.

  7. H- Ion Sources for High Intensity Proton Drivers

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Rolland Paul [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dudnikov, Vadim [Muons, Inc., Batavia, IL (United States)

    2015-02-20

    Existing RF Surface Plasma Sources (SPS) for accelerators have specific efficiencies for H+ and H- ion generation around 3 to 5 mA/cm2 per kW, where about 50 kW of RF power is typically needed for 50 mA beam current production. The Saddle Antenna (SA) SPS described here was developed to improve H- ion production efficiency, reliability and availability for pulsed operation as used in the ORNL Spallation Neutron Source . At low RF power, the efficiency of positive ion generation in the plasma has been improved to 200 mA/cm2 per kW of RF power at 13.56 MHz. Initial cesiation of the SPS was performed by heating cesium chromate cartridges by discharge as was done in the very first versions of the SPS. A small oven to decompose cesium compounds and alloys was developed and tested. After cesiation, the current of negative ions to the collector was increased from 1 mA to 10 mA with RF power 1.5 kW in the plasma (6 mm diameter emission aperture) and up to 30 mA with 4 kW RF power in the plasma and 250 Gauss longitudinal magnetic field. The ratio of electron current to negative ion current was improved from 30 to 2. Stable generation of H- beam without intensity degradation was demonstrated in the aluminum nitride (AlN) discharge chamber for 32 days at high discharge power in an RF SPS with an external antenna. Some modifications were made to improve the cooling and cesiation stability. The extracted collector current can be increased significantly by optimizing the longitudinal magnetic field in the discharge chamber. While this project demonstrated the advantages of the pulsed version of the SA RF SPS as an upgrade to the ORNL Spallation Neutron Source, it led to a possibility for upgrades to CW machines like the many cyclotrons used for commercial applications. Four appendices contain important details of the work carried out under this grant.

  8. Proton Acceleration Drived by High-intensity Ultraviolet Laser

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The generation of energetic protons from a solid thin-foil by the interactions of ultra-short and intense laser pulses is investigated in numerous experiments in the last decade. The energetic proton beams are promising candidates for proton fast ignitor (PFI)

  9. Overview of novel photovoltaic conversion techniques at high intensity levels

    Science.gov (United States)

    Stirn, R. J.

    1978-01-01

    The paper describes several photovoltaic devices currently under development that can operate under light intensities considerably higher than can silicon solar cells. The technologies discussed include GaAs heteroface solar cells, multi-color systems, thermophotovoltaics, and laser energy conversion. Array costs for the GaAs and multi-color elements are estimated.

  10. Experimental Research at the Intensity Frontier in High Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Marshak, Marvin L. [Univ. of Minnesota, Minneapolis, MN (United States)

    2014-06-30

    This Final Report describes DOE-supported Intensity Frontier research by the University of Minnesota during the interval April 1, 2011 to March 31, 2014. Primary activities included the MINOS, NOvA and LBNE Experiments and Heavy Quark studies at BES III.

  11. Feeding cosmic star formation: exploring high-redshift molecular gas with CO intensity mapping

    Science.gov (United States)

    Breysse, Patrick C.; Rahman, Mubdi

    2017-06-01

    The study of molecular gas is crucial for understanding star formation, feedback and the broader ecosystem of a galaxy as a whole. However, we have limited understanding of its physics and distribution in all but the nearest galaxies. We present a new technique for studying the composition and distribution of molecular gas in high-redshift galaxies inaccessible to existing methods. Our proposed approach is an extension of carbon monoxide intensity mapping methods, which have garnered significant experimental interest in recent years. These intensity mapping surveys target the 115 GHz 12CO (1-0) line, but also contain emission from the substantially fainter 110 GHz 13CO (1-0) transition. The method leverages the information contained in the 13CO line by cross-correlating pairs of frequency channels in an intensity mapping survey. Since 13CO is emitted from the same medium as the 12CO, but saturates at a much higher column density, this cross-correlation provides valuable information about both the gas density distribution and isotopologue ratio, inaccessible from the 12CO alone. Using a simple model of these molecular emission lines, we show that a future intensity mapping survey can constrain the abundance ratio of these two species and the fraction of emission from optically thick regions to order ˜30 per cent. These measurements cannot be made by traditional CO observations, and consequently the proposed method will provide unique insight into the physics of star formation, feedback and galactic ecology at high redshifts.

  12. Benchmark of Space Charge Simulations and Comparison with Experimental Results for High Intensity, Low Energy Accelerators

    CERN Document Server

    Cousineau, Sarah M

    2005-01-01

    Space charge effects are a major contributor to beam halo and emittance growth leading to beam loss in high intensity, low energy accelerators. As future accelerators strive towards unprecedented levels of beam intensity and beam loss control, a more comprehensive understanding of space charge effects is required. A wealth of simulation tools have been developed for modeling beams in linacs and rings, and with the growing availability of high-speed computing systems, computationally expensive problems that were inconceivable a decade ago are now being handled with relative ease. This has opened the field for realistic simulations of space charge effects, including detailed benchmarks with experimental data. A great deal of effort is being focused in this direction, and several recent benchmark studies have produced remarkably successful results. This paper reviews the achievements in space charge benchmarking in the last few years, and discusses the challenges that remain.

  13. Max Tech and Beyond: High-Intensity Discharge Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Scholand, Michael

    2012-04-01

    High-intensity discharge (HID) lamps are most often found in industrial and commercial applications, and are the light source of choice in street and area lighting, and sports stadium illumination. HID lamps are produced in three types - mercury vapor (MV), high pressure sodium (HPS) and metal halide (MH). Of these, MV and MH are considered white-light sources (although the MV exhibits poor color rendering) and HPS produces a yellow-orange color light. A fourth lamp, low-pressure sodium (LPS), is not a HID lamp by definition, but it is used in similar applications and thus is often grouped with HID lamps. With the notable exception of MV which is comparatively inefficient and in decline in the US from both a sales and installed stock point of view; HPS, LPS and MH all have efficacies over 100 lumens per watt. The figure below presents the efficacy trends over time for commercially available HID lamps and LPS, starting with MV and LPS in 1930's followed by the development of HPS and MH in the 1960's. In HID lamps, light is generated by creating an electric arc between two electrodes in an arc tube. The particles in the arc are partially ionized, making them electrically conductive, and a light-emitting 'plasma' is created. This arc occurs within the arc tube, which for most HID lamps is enclosed within an evacuated outer bulb that thermally isolates and protects the hot arc tube from the surroundings. Unlike a fluorescent lamp that produces visible light through down-converting UV light with phosphors, the arc itself is the light source in an HID lamp, emitting visible radiation that is characteristic of the elements present in the plasma. Thus, the mixture of elements included in the arc tube is one critical factor determining the quality of the light emitted from the lamp, including its correlated color temperature (CCT) and color rendering index (CRI). Similar to fluorescent lamps, HID lamps require a ballast to start and maintain stable

  14. Max Tech and Beyond: High-Intensity Discharge Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Scholand, Michael

    2012-04-01

    High-intensity discharge (HID) lamps are most often found in industrial and commercial applications, and are the light source of choice in street and area lighting, and sports stadium illumination. HID lamps are produced in three types - mercury vapor (MV), high pressure sodium (HPS) and metal halide (MH). Of these, MV and MH are considered white-light sources (although the MV exhibits poor color rendering) and HPS produces a yellow-orange color light. A fourth lamp, low-pressure sodium (LPS), is not a HID lamp by definition, but it is used in similar applications and thus is often grouped with HID lamps. With the notable exception of MV which is comparatively inefficient and in decline in the US from both a sales and installed stock point of view; HPS, LPS and MH all have efficacies over 100 lumens per watt. The figure below presents the efficacy trends over time for commercially available HID lamps and LPS, starting with MV and LPS in 1930's followed by the development of HPS and MH in the 1960's. In HID lamps, light is generated by creating an electric arc between two electrodes in an arc tube. The particles in the arc are partially ionized, making them electrically conductive, and a light-emitting 'plasma' is created. This arc occurs within the arc tube, which for most HID lamps is enclosed within an evacuated outer bulb that thermally isolates and protects the hot arc tube from the surroundings. Unlike a fluorescent lamp that produces visible light through down-converting UV light with phosphors, the arc itself is the light source in an HID lamp, emitting visible radiation that is characteristic of the elements present in the plasma. Thus, the mixture of elements included in the arc tube is one critical factor determining the quality of the light emitted from the lamp, including its correlated color temperature (CCT) and color rendering index (CRI). Similar to fluorescent lamps, HID lamps require a ballast to start and maintain stable

  15. IT Business Value Model for Information Intensive Organizations

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Gastaud Maçada

    2012-01-01

    Full Text Available Many studies have highlighted the capacity Information Technology (IT has for generating value for organizations. Investments in IT made by organizations have increased each year. Therefore, the purpose of the present study is to analyze the IT Business Value for Information Intensive Organizations (IIO - e.g. banks, insurance companies and securities brokers. The research method consisted of a survey that used and combined the models from Weill and Broadbent (1998 and Gregor, Martin, Fernandez, Stern and Vitale (2006. Data was gathered using an adapted instrument containing 5 dimensions (Strategic, Informational, Transactional, Transformational and Infra-structure with 27 items. The instrument was refined by employing statistical techniques such as Exploratory and Confirmatory Factorial Analysis through Structural Equations (first and second order Model Measurement. The final model is composed of four factors related to IT Business Value: Strategic, Informational, Transactional and Transformational, arranged in 15 items. The dimension Infra-structure was excluded during the model refinement process because it was discovered during interviews that managers were unable to perceive it as a distinct dimension of IT Business Value.

  16. Reflectivity of plasmas created by high-intensity, ultra-short laser pulses

    Energy Technology Data Exchange (ETDEWEB)

    Gold, D.M.

    1994-06-01

    Experiments were performed to characterize the creation and evolution of high-temperature (T{sub e}{approximately}100eV), high-density (n{sub e}>10{sup 22}cm{sup {minus}3}) plasmas created with intense ({approximately}10{sup 12}-10{sup 16}W/cm{sup 2}), ultra-short (130fs) laser pulses. The principle diagnostic was plasma reflectivity at optical wavelengths (614nm). An array of target materials (Al, Au, Si, SiO{sub 2}) with widely differing electronic properties tested plasma behavior over a large set of initial states. Time-integrated plasma reflectivity was measured as a function of laser intensity. Space- and time-resolved reflectivity, transmission and scatter were measured with a spatial resolution of {approximately}3{mu}m and a temporal resolution of 130fs. An amplified, mode-locked dye laser system was designed to produce {approximately}3.5mJ, {approximately}130fs laser pulses to create and nonintrusively probe the plasmas. Laser prepulse was carefully controlled to suppress preionization and give unambiguous, high-density plasma results. In metals (Al and Au), it is shown analytically that linear and nonlinear inverse Bremsstrahlung absorption, resonance absorption, and vacuum heating explain time-integrated reflectivity at intensities near 10{sup 16}W/cm{sup 2}. In the insulator, SiO{sub 2}, a non-equilibrium plasma reflectivity model using tunneling ionization, Helmholtz equations, and Drude conductivity agrees with time-integrated reflectivity measurements. Moreover, a comparison of ionization and Saha equilibration rates shows that plasma formed by intense, ultra-short pulses can exist with a transient, non-equilibrium distribution of ionization states. All targets are shown to approach a common reflectivity at intensities {approximately}10{sup 16}W/cm{sup 2}, indicating a material-independent state insensitive to atomic or solid-state details.

  17. Understanding laser-solid interactions at ultra-high intensities

    Science.gov (United States)

    Murphy, C. D.; Gray, R. J.; Carroll, D. C.; MacLellan, D. A.; Powell, H.; Scott, G. G.; Ridgers, C. P.; Brady, C. S.; Neely, D.; Green, J. S.; Booth, N.; McKenna, P.

    2012-10-01

    The interaction of matter with lasers is a subject which has progressed rapidly over the last two decades as higher intensity lasers have opened the door to nonlinear and then relativistic interactions such that applications in ion acceleration and x-ray backlighting sources have become a clear possibility. Until recently, lasers capable of reaching the highest intensities (˜10^21 Wcm-2) have been glass-based systems with a low shot rate making detailed studies prohibitively time consuming. The development of petawatt-class Ti:Sapphire lasers such as Astra Gemini at STFC - Rutherford Appleton Laboratory, has made the systematic studies required to understand such interaction physics feasible. One such experiment on the Astra Gemini laser will be presented. The photon and particle diagnostics used will be explained and their results presented.

  18. On the GCR intensity and the inversion of the heliospheric magnetic field during the periods of the high solar activity

    CERN Document Server

    Krainev, M B

    2014-01-01

    We consider the long-term behavior of the solar and heliospheric parameters and the GCR intensity in the periods of high solar activity and the inversions of heliospheric magnetic field (HMF). The classification of the HMF polarity structures and the meaning of the HMF inversion are discussed. The procedure is considered how to use the known HMF polarity distribution for the GCR intensity modeling during the periods of high solar activity. We also briefly discuss the development and the nearest future of the sunspot activity and the GCR intensity in the current unusual solar cycle 24.

  19. Ionization Chambers for Monitoring in High-Intensity Neutrino Beams

    CERN Document Server

    McDonald, J; Velissaris, C; Erwin, A R; Ping, H; Viren, B M; Diwan, M V

    2002-01-01

    Radiation-hard ionization chambers were tested using an intense electron beam from the accelerator test facility (ATF) at the Brookhaven National Laboratory (BNL). The detectors were designed to be used as the basic element for monitoring muons in the Main Injector Neutrino beamline (NuMI) at the Fermi National Accelerator Laboratory (FNAL). Measurements of linearity of response, voltage dependence, and the onset of ionization saturation as a function of gap voltage were performed.

  20. Development of a cryogenic hydrogen microjet for high-intensity, high-repetition rate experiments

    Science.gov (United States)

    Kim, J. B.; Göde, S.; Glenzer, S. H.

    2016-11-01

    The advent of high-intensity, high-repetition-rate lasers has led to the need for replenishing targets of interest for high energy density sciences. We describe the design and characterization of a cryogenic microjet source, which can deliver a continuous stream of liquid hydrogen with a diameter of a few microns. The jet has been imaged at 1 μm resolution by shadowgraphy with a short pulse laser. The pointing stability has been measured at well below a mrad, for a stable free-standing filament of solid-density hydrogen.

  1. Complex data modeling and computationally intensive methods for estimation and prediction

    CERN Document Server

    Secchi, Piercesare; Advances in Complex Data Modeling and Computational Methods in Statistics

    2015-01-01

    The book is addressed to statisticians working at the forefront of the statistical analysis of complex and high dimensional data and offers a wide variety of statistical models, computer intensive methods and applications: network inference from the analysis of high dimensional data; new developments for bootstrapping complex data; regression analysis for measuring the downsize reputational risk; statistical methods for research on the human genome dynamics; inference in non-euclidean settings and for shape data; Bayesian methods for reliability and the analysis of complex data; methodological issues in using administrative data for clinical and epidemiological research; regression models with differential regularization; geostatistical methods for mobility analysis through mobile phone data exploration. This volume is the result of a careful selection among the contributions presented at the conference "S.Co.2013: Complex data modeling and computationally intensive methods for estimation and prediction" held...

  2. The high redshift star-formation history from carbon-monoxide intensity maps

    CERN Document Server

    Breysse, Patrick C; Kamionkowski, Marc

    2015-01-01

    We demonstrate how cosmic star-formation history can be measured with one-point statistics of carbon-monoxide intensity maps. Using a P(D) analysis, the luminosity function of CO-emitting sources can be inferred from the measured one-point intensity PDF. The star-formation rate density (SFRD) can then be obtained, at several redshifts, from the CO luminosity density. We study the effects of instrumental noise, line foregrounds, and target redshift, and obtain constraints on the CO luminosity density of order 10%. We show that the SFRD uncertainty is dominated by that of the model connecting CO luminosity and star formation. For pessimistic estimates of this model uncertainty, we obtain an error of order 50% on SFRD for surveys targeting redshifts between 2 and 7 with reasonable noise and foregrounds included. However, comparisons between intensity maps and galaxies could substantially reduce this model uncertainty. In this case our constraints on SFRD at these redshifts improve to roughly 5-10%, which is high...

  3. The high-redshift star formation history from carbon-monoxide intensity maps

    Science.gov (United States)

    Breysse, Patrick C.; Kovetz, Ely D.; Kamionkowski, Marc

    2016-03-01

    We demonstrate how cosmic star formation history can be measured with one-point statistics of carbon-monoxide intensity maps. Using a P(D) analysis, the luminosity function of CO-emitting sources can be inferred from the measured one-point intensity PDF. The star formation rate density (SFRD) can then be obtained, at several redshifts, from the CO luminosity density. We study the effects of instrumental noise, line foregrounds, and target redshift, and obtain constraints on the CO luminosity density of the order of 10 per cent. We show that the SFRD uncertainty is dominated by that of the model connecting CO luminosity and star formation. For pessimistic estimates of this model uncertainty, we obtain an error of the order of 50 per cent on SFRD for surveys targeting redshifts between two and seven with reasonable noise and foregrounds included. However, comparisons between intensity maps and galaxies could substantially reduce this model uncertainty. In this case, our constraints on SFRD at these redshifts improve to roughly 5 - 10 per cent, which is highly competitive with current measurements.

  4. Modeling nitrogen plasmas produced by intense electron beams

    Energy Technology Data Exchange (ETDEWEB)

    Angus, J. R.; Swanekamp, S. B.; Schumer, J. W.; Hinshelwood, D. D. [Plasma Physics Division, Naval Research Laboratory, Washington, DC 20375 (United States); Mosher, D.; Ottinger, P. F. [Independent contractors for NRL through Engility, Inc., Alexandria, Virginia 22314 (United States)

    2016-05-15

    A new gas–chemistry model is presented to treat the breakdown of a nitrogen gas with pressures on the order of 1 Torr from intense electron beams with current densities on the order of 10 kA/cm{sup 2} and pulse durations on the order of 100 ns. For these parameter regimes, the gas transitions from a weakly ionized molecular state to a strongly ionized atomic state on the time scale of the beam pulse. The model is coupled to a 0D–circuit model using the rigid–beam approximation that can be driven by specifying the time and spatial profiles of the beam pulse. Simulation results are in good agreement with experimental measurements of the line–integrated electron density from experiments done using the Gamble II generator at the Naval Research Laboratory. It is found that the species are mostly in the ground and metastable states during the atomic phase, but that ionization proceeds predominantly through thermal ionization of optically allowed states with excitation energies close to the ionization limit.

  5. Experimental verification of a model describing the intensity distribution from a single mode optical fiber

    Energy Technology Data Exchange (ETDEWEB)

    Moro, Erik A [Los Alamos National Laboratory; Puckett, Anthony D [Los Alamos National Laboratory; Todd, Michael D [UCSD

    2011-01-24

    The intensity distribution of a transmission from a single mode optical fiber is often approximated using a Gaussian-shaped curve. While this approximation is useful for some applications such as fiber alignment, it does not accurately describe transmission behavior off the axis of propagation. In this paper, another model is presented, which describes the intensity distribution of the transmission from a single mode optical fiber. A simple experimental setup is used to verify the model's accuracy, and agreement between model and experiment is established both on and off the axis of propagation. Displacement sensor designs based on the extrinsic optical lever architecture are presented. The behavior of the transmission off the axis of propagation dictates the performance of sensor architectures where large lateral offsets (25-1500 {micro}m) exist between transmitting and receiving fibers. The practical implications of modeling accuracy over this lateral offset region are discussed as they relate to the development of high-performance intensity modulated optical displacement sensors. In particular, the sensitivity, linearity, resolution, and displacement range of a sensor are functions of the relative positioning of the sensor's transmitting and receiving fibers. Sensor architectures with high combinations of sensitivity and displacement range are discussed. It is concluded that the utility of the accurate model is in its predicative capability and that this research could lead to an improved methodology for high-performance sensor design.

  6. Application of the speed-duration relationship to normalize the intensity of high-intensity interval training.

    Directory of Open Access Journals (Sweden)

    Carrie Ferguson

    Full Text Available The tolerable duration of continuous high-intensity exercise is determined by the hyperbolic Speed-tolerable duration (S-tLIM relationship. However, application of the S-tLIM relationship to normalize the intensity of High-Intensity Interval Training (HIIT has yet to be considered, with this the aim of present study. Subjects completed a ramp-incremental test, and series of 4 constant-speed tests to determine the S-tLIM relationship. A sub-group of subjects (n = 8 then repeated 4 min bouts of exercise at the speeds predicted to induce intolerance at 4 min (WR4, 6 min (WR6 and 8 min (WR8, interspersed with bouts of 4 min recovery, to the point of exercise intolerance (fixed WR HIIT on different days, with the aim of establishing the work rate that could be sustained for 960 s (i.e. 4×4 min. A sub-group of subjects (n = 6 also completed 4 bouts of exercise interspersed with 4 min recovery, with each bout continued to the point of exercise intolerance (maximal HIIT to determine the appropriate protocol for maximizing the amount of high-intensity work that can be completed during 4×4 min HIIT. For fixed WR HIIT tLIM of HIIT sessions was 399±81 s for WR4, 892±181 s for WR6 and 1517±346 s for WR8, with total exercise durations all significantly different from each other (P0.050. However, there was significantly less high-intensity work completed during bouts 2 (153.5±40. 9 m, 3 (136.9±38.9 m, and 4 (136.7±39.3 m, compared with bout 1 (264.9±58.7 m; P>0.050. These data establish that WR6 provides the appropriate work rate to normalize the intensity of HIIT between subjects. Maximal HIIT provides a protocol which allows the relative contribution of the work rate profile to physiological adaptations to be considered during alternative intensity-matched HIIT protocols.

  7. Application of the speed-duration relationship to normalize the intensity of high-intensity interval training.

    Science.gov (United States)

    Ferguson, Carrie; Wilson, John; Birch, Karen M; Kemi, Ole J

    2013-01-01

    The tolerable duration of continuous high-intensity exercise is determined by the hyperbolic Speed-tolerable duration (S-tLIM) relationship. However, application of the S-tLIM relationship to normalize the intensity of High-Intensity Interval Training (HIIT) has yet to be considered, with this the aim of present study. Subjects completed a ramp-incremental test, and series of 4 constant-speed tests to determine the S-tLIM relationship. A sub-group of subjects (n = 8) then repeated 4 min bouts of exercise at the speeds predicted to induce intolerance at 4 min (WR4), 6 min (WR6) and 8 min (WR8), interspersed with bouts of 4 min recovery, to the point of exercise intolerance (fixed WR HIIT) on different days, with the aim of establishing the work rate that could be sustained for 960 s (i.e. 4×4 min). A sub-group of subjects (n = 6) also completed 4 bouts of exercise interspersed with 4 min recovery, with each bout continued to the point of exercise intolerance (maximal HIIT) to determine the appropriate protocol for maximizing the amount of high-intensity work that can be completed during 4×4 min HIIT. For fixed WR HIIT tLIM of HIIT sessions was 399±81 s for WR4, 892±181 s for WR6 and 1517±346 s for WR8, with total exercise durations all significantly different from each other (PHIIT, there was no difference in tLIM of each of the 4 bouts (Bout 1: 229±27 s; Bout 2: 262±37 s; Bout 3: 235±49 s; Bout 4: 235±53 s; P>0.050). However, there was significantly less high-intensity work completed during bouts 2 (153.5±40. 9 m), 3 (136.9±38.9 m), and 4 (136.7±39.3 m), compared with bout 1 (264.9±58.7 m; P>0.050). These data establish that WR6 provides the appropriate work rate to normalize the intensity of HIIT between subjects. Maximal HIIT provides a protocol which allows the relative contribution of the work rate profile to physiological adaptations to be considered during alternative intensity-matched HIIT protocols.

  8. Causative factors of high intensity areas identified by MRI in the pontine base

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Masaki; Takahashi, Akira [Nagoya Univ. (Japan). Faculty of Medicine; Arahata, Yutaka; Motegi, Yoshimasa

    1994-08-01

    High intensity areas in the pontine base were found more frequently in patients of group A who had multiple supratentorial high intensity areas smaller than 15 mm in size and of group B whose vertebral arteries were asymmetric on MR angiography, as compared to those who had none of the above findings of MRI and MR angiography. The high intensity areas of group A were often found bilaterally in the upper pons and those of group B were present unilaterally in the lower pons. Pontine high intensity areas were found frequently on the same side as the smaller vertebral artery in group B. Periventricular hyperintensity was more severe in group A than than in group B. These results suggest that high intensity lesions in the pontine base may conform with the following conditions: (1) multiple small high intensity areas in the supratentorium due to diffuse arteriosclerosis, and (2) asymmetry of the vertebral arteries inducing hemodynamic disorders. (author).

  9. Beam dynamics of mixed high intensity highly charged ion Beams in the Q/A selector

    Science.gov (United States)

    Zhang, X. H.; Yuan, Y. J.; Yin, X. J.; Qian, C.; Sun, L. T.; Du, H.; Li, Z. S.; Qiao, J.; Wang, K. D.; Zhao, H. W.; Xia, J. W.

    2017-06-01

    Electron cyclotron resonance (ECR) ion sources are widely used in heavy ion accelerators for their advantages in producing high quality intense beams of highly charged ions. However, it exists challenges in the design of the Q/A selection systems for mixed high intensity ion beams to reach sufficient Q/A resolution while controlling the beam emittance growth. Moreover, as the emittance of beam from ECR ion sources is coupled, the matching of phase space to post accelerator, for a wide range of ion beam species with different intensities, should be carefully studied. In this paper, the simulation and experimental results of the Q/A selection system at the LECR4 platform are shown. The formation of hollow cross section heavy ion beam at the end of the Q/A selector is revealed. A reasonable interpretation has been proposed, a modified design of the Q/A selection system has been committed for HIRFL-SSC linac injector. The features of the new design including beam simulations and experiment results are also presented.

  10. The effect of progressive high-intensity inspiratory muscle training and fixed high-intensity inspiratory muscle training on the asymmetry of diaphragm thickness in stroke patients.

    Science.gov (United States)

    Jung, Ju-Hyeon; Kim, Nan-Soo

    2015-10-01

    [Purpose] This study investigated the effects of progressive load and fixed load high-intensity inspiratory muscle training on the asymmetry of diaphragm thickness in stroke patients. [Subjects] Twenty-one stroke patients were assigned to one of three groups: progressive load high-intensity inspiratory muscle training (n = 8), fixed load high-intensity inspiratory muscle training (n = 6), and controls (n = 7). [Methods] The progressive load and fixed load high-intensity inspiratory muscle training participants undertook an exercise program for 20 minutes, three times weekly, for 6 weeks. After each session, diaphragm thickness was measured using ultrasonography. The diaphragm asymmetry ratio and diaphragm thickening ratio were standardized using a formula. [Results] After intervention, the diaphragm asymmetry ratio significantly differed among the three groups, and the diaphragm asymmetry ratio significantly increased in the control group. A significant increase was identified in the diaphragm thickening ratio within the progressive load and fixed load high-intensity inspiratory muscle training groups. [Conclusion] Progressive load and fixed load high-intensity inspiratory muscle training decreased the asymmetry of diaphragm thickness in stroke patients; this effect, in turn, increased the diaphragm thickening ratio in stroke patients. The two interventions examined here should be selectively applied to individuals in the clinical field.

  11. A common genetic influence on human intensity ratings of sugars and high-potency sweeteners.

    Science.gov (United States)

    Hwang, Liang-Dar; Zhu, Gu; Breslin, Paul A S; Reed, Danielle R; Martin, Nicholas G; Wright, Margaret J

    2015-08-01

    The perception of sweetness varies among individuals but the sources of this variation are not fully understood. Here, in a sample of 1,901 adolescent and young adults (53.8% female; 243 MZ and 452 DZ twin pairs, 511 unpaired individuals; mean age 16.2±2.8, range 12–26 years), we studied the variation in the perception of sweetness intensity of two monosaccharides and two high-potency sweeteners: glucose, fructose, neohesperidine dihydrochalcone (NHDC), and aspartame. Perceived intensity for all sweeteners decreased with age (2–5% per year) and increased with the history of otitis media (6–9%). Males rated aspartame slightly stronger than females (7%). We found similar heritabilities for sugars (glucose: h2=0.31, fructose: h2=0.34) and high-potency sweeteners (NHDC: h2=0.31, aspartame: h2=0.30); all were in the modest range. Multivariate modeling showed that a common genetic factor accounted for >75% of the genetic variance in the four sweeteners, suggesting that individual differences in perceived sweet intensity, which are partly due to genetic factors, may be attributed to a single set of genes. This study provided evidence of the shared genetic pathways between the perception of sugars and high-potency sweeteners.

  12. A metastatistical approach to modelling extreme hurricane intensities

    Science.gov (United States)

    Hosseini, Seyed Reza; Marani, Marco; Scaioni, Marco

    2017-04-01

    Estimating the probability of occurrence of extreme hurricane intensities is significant in a vast number of fields and plays a crucial role in hurricane risk assessment. The method typically employed for these analyses applies traditional Extreme Value Theory (EVT) to fit the Generalize Extreme Value Distribution (GEVD) to hurricane maximum wind speed. In this framework, an asymptotic regime or a Poisson occurrence process are assumed to derive the GEVD, which is fitted using values over a high threshold or yearly maxima. However, the relative rarity of hurricanes implies that the number of events per year is not nearly sufficient for this asymptotic hypothesis to be valid, and the selection of a subset of the events drastically reduces the amount of information used. To overcome this limitation, we apply an alternative approach based on the Metastatistical Extreme Value Distribution (MEVD) to extreme hurricane intensity analyses. The derivation of the MEVD relaxes the limiting assumption of the traditional EVT, by taking into account the distribution of the entire range of recorded event magnitudes, rather than just the distributional tail. Taking advantage of this method, we can use the entire observational set, including hurricanes with relatively lower intensities, with clear statistical advantages. We comparatively assess the MEVD and the classical EVT quantile estimation uncertainties using the 130-year long Maximum Sustained Wind (MSW) speed time series for all hurricanes in the north Atlantic basin obtained from the National Hurricane Center (Atlantic HURDAT2). The parameters of the GEVD are estimated using a range of methods to ensure an optimal estimator is found. The MEVD is fitted assuming a Generalize Pareto Distribution (GPD) for the "ordinary" values of MSW over 5- to 10-year blocks using Probability Weighted Moments (PWM). The statistical tests are performed by dividing the dataset (of length L) into two distinct parts: S years for calibration and

  13. Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk

    Science.gov (United States)

    Fleg, Jerome L.

    2016-01-01

    Although moderate-intensity continuous training (MICT) has been the traditional model for aerobic exercise training for over four decades, a growing body of literature has demonstrated equal if not greater improvement in aerobic capacity and similar beneficial effects on body composition, glucose metabolism, blood pressure, and quality of life from high-intensity interval training (HIIT). An advantage of HIIT over MICT is the shorter time required to perform the same amount of energy expenditure. The current brief review summarizes the effects of HIIT on peak aerobic capacity and cardiovascular risk factors in healthy adults and those with various cardiovascular diseases, including coronary artery disease, chronic heart failure, and post heart transplantation. PMID:27635241

  14. High harmonic generation in underdense plasmas by intense laser pulses with orbital angular momentum

    Energy Technology Data Exchange (ETDEWEB)

    Mendonça, J. T., E-mail: josetitomend@gmail.com [IPFN, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal and Instituto de Física, Universidade de São Paulo, 05508-090 São Paulo, SP (Brazil); Vieira, J., E-mail: jorge.vieira@ist.utl.pt [GoLP, IPFN, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa (Portugal)

    2015-12-15

    We study high harmonic generation produced by twisted laser pulses, with orbital angular momentum in the relativistic regime, for pulse propagation in underdense plasma. We consider fast time scale processes associated with an ultra-short pulse, where the ion motion can be neglected. We use both analytical models and numerical simulations using a relativistic particle-in-cell code. The present description is valid for relativistic laser intensities, when the normalized field amplitude is much larger than one, a ≫ 1. We also discuss two distinct processes associated with linear and circular polarization. Using both analytical solutions and particle-in-cell simulations, we are able to show that, for laser pulses in a well defined Laguerre-Gauss mode, angular momentum conservation is observed during the process of harmonic generation. Intensity modulation of the harmonic spectrum is also verified, as imposed by the nonlinear time-scale for energy transfer between different harmonics.

  15. Enhancing gas-phase reaction in a plasma using high intensity and high power ultrasonic acoustic waves

    DEFF Research Database (Denmark)

    2010-01-01

    is absorbed into said plasma (104), and where a sound pressure level of said generated ultrasonic high intensity and high power acoustic waves (102) is at least substantially 140 dB and where an acoustic power of said generated ultrasonic high intensity and high power acoustic waves (102); is at least......This invention relates to enhancing a gas-phase reaction in a plasma comprising: creating plasma (104) by at least one plasma source (106), and wherein that the method further comprises: generating ultrasonic high intensity and high power acoustic waves (102) having a predetermined amount...... of acoustic energy by at least one ultrasonic high intensity and high power gas-jet acoustic wave generator (101), where said ultrasonic high intensity and high power acoustic waves are directed to propagate towards said plasma (104) so that at least a part of said predetermined amount of acoustic energy...

  16. Self-organization of high intensity laser pulses propagating in gases

    Energy Technology Data Exchange (ETDEWEB)

    Koga, James [Japan Atomic Energy Research Inst., Kizu, Kyoto (Japan). Kansai Research Establishment

    2001-10-01

    In recent years the development of high intensity short pulse lasers has opened up wide fields of science which had previously been difficult to study. Recent experiments of short pulse lasers propagating in air have shown that these laser pulses can propagate over very long distances (up to 12 km) with little or no distortion of the pulse. Here we present a model of this propagation using a modified version of the self-organized criticality model developed for sandpiles by Bak, Tang, and Weisenfeld. The additions to the sandpile model include the formation of plasma which acts as a threshold diffusion term and self-focusing by the nonlinear index of refraction which acts as a continuous inverse diffusion. Results of this simple model indicate that a strongly self-focusing laser pulse shows self-organized critical behavior. (author)

  17. Personalized metabolomics for predicting glucose tolerance changes in sedentary women after high-intensity interval training

    National Research Council Canada - National Science Library

    Kuehnbaum, Naomi L; Gillen, Jenna B; Gibala, Martin J; Britz-McKibbin, Philip

    2014-01-01

    High-intensity interval training (HIIT) offers a practical approach for enhancing cardiorespiratory fitness, however its role in improving glucose regulation among sedentary yet normoglycemic women remains unclear...

  18. Nakagami imaging for detecting thermal lesions induced by high-intensity focused ultrasound in tissue.

    Science.gov (United States)

    Rangraz, Parisa; Behnam, Hamid; Tavakkoli, Jahan

    2014-01-01

    High-intensity focused ultrasound induces focalized tissue coagulation by increasing the tissue temperature in a tight focal region. Several methods have been proposed to monitor high-intensity focused ultrasound-induced thermal lesions. Currently, ultrasound imaging techniques that are clinically used for monitoring high-intensity focused ultrasound treatment are standard pulse-echo B-mode ultrasound imaging, ultrasound temperature estimation, and elastography-based methods. On the contrary, the efficacy of two-dimensional Nakagami parametric imaging based on the distribution of the ultrasound backscattered signals to quantify properties of soft tissue has recently been evaluated. In this study, ultrasound radio frequency echo signals from ex vivo tissue samples were acquired before and after high-intensity focused ultrasound exposures and then their Nakagami parameter and scaling parameter of Nakagami distribution were estimated. These parameters were used to detect high-intensity focused ultrasound-induced thermal lesions. Also, the effects of changing the acoustic power of the high-intensity focused ultrasound transducer on the Nakagami parameters were studied. The results obtained suggest that the Nakagami distribution's scaling and Nakagami parameters can effectively be used to detect high-intensity focused ultrasound-induced thermal lesions in tissue ex vivo. These parameters can also be used to understand the degree of change in tissue caused by high-intensity focused ultrasound exposures, which could be interpreted as a measure of degree of variability in scatterer concentration in various parts of the high-intensity focused ultrasound lesion.

  19. Towards phasing using high X-ray intensity

    Directory of Open Access Journals (Sweden)

    Lorenzo Galli

    2015-11-01

    Full Text Available X-ray free-electron lasers (XFELs show great promise for macromolecular structure determination from sub-micrometre-sized crystals, using the emerging method of serial femtosecond crystallography. The extreme brightness of the XFEL radiation can multiply ionize most, if not all, atoms in a protein, causing their scattering factors to change during the pulse, with a preferential `bleaching' of heavy atoms. This paper investigates the effects of electronic damage on experimental data collected from a Gd derivative of lysozyme microcrystals at different X-ray intensities, and the degree of ionization of Gd atoms is quantified from phased difference Fourier maps. A pattern sorting scheme is proposed to maximize the ionization contrast and the way in which the local electronic damage can be used for a new experimental phasing method is discussed.

  20. The risk of retina damage from high intensity light sources.

    Science.gov (United States)

    Pollak, V A; Romanchuk, K G

    1980-05-01

    The risk of thermal damage to the retina of the eye by exposure to excessive light intensities from continuous and pulsed man-made sources is discussed. The probability of injury increases, the larger the radiant power absorbed by the retina and the smaller the size of the retinal image of the source. A mehtod of estimating the temperature increase of the immediately affected area of the retina is presented. The time constants involved are also briefly considered. Using numerical values from literature for the relevant parameters of the eye, threshold values for a variety of conditions can be established. Below these values little risk of retina damage should exist. The degree of hazard when these values are exceeded depends upon the circumstances. A case study of a welding accident showed good agreement between the conclusions of the theoretical analysis and clinical findings.

  1. Transverse feedback: high intensity operation, AGC, IGC, lessons for 2012

    CERN Document Server

    Höfle, W

    2012-01-01

    The transverse damper system (ADT) plays an important role in the preservation of the beam transverse emittance and for damping of oscillations driven by the coupled bunch instability. An overview of the ADT system will be presented with an emphasis on the important feedback loop parameters as they change from injection through the ramp into collision. The dedicated setting - up procedure required for the different bunch intensities and bunch spacings will be explained. During the 2011 run the injection and abort gap cleaning became operational at injection energy. Preparations for cleaning at 3.5 TeV as well as batch selective transverse blow - up were completed and preliminarily tested. Plans for 2012 include study and potential improvement of the system impulse response to improve the 'selectivity' of the cleaning and blow - up facility. The ADT also provides bunch - by - bunch observation, which was extensively used during the run and MDs, and will be further upgraded during the next year.

  2. New initiatives on lepton flavor violation and neutrino oscillation with high intense muon and neutrino sources

    CERN Document Server

    Kuno, Yoshitaka; Pakvasa, Sandip

    2002-01-01

    The area of physics involving muons and neutrinos has become exciting in particle physics. Using their high intensity sources, physicists undertake, in various ways, extensive searches for new physics beyond the Standard Model, such as tests of supersymmetric grand unification (SUSY-GUT) and precision measurements of the muon and neutrino properties, which will in future extend to ambitious studies such as determination of the three-generation neutrino mixing matrix elements and CP violation in the lepton sector. The physics of this field is advancing, with potential improvements of the source

  3. Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To investigate whether tumor debris created by high-intensity focused ultrasound(HIFU)could trigger antitumor immunity in a mouse hepatocellular carcinoma model. METHODS:Twenty C57BL/6J mice bearing H22 hepatocellular carcinoma were used to generate antitumor vaccines.Ten mice underwent HIFU ablation,and the remaining 10 mice received a sham-HIFU procedure with no ultrasound irradiation.Sixty normal mice were randomly divided into HIFU vaccine,tumor vaccine and control groups.These mice were immunized w...

  4. Interaction of intense femtosecond laser pulses with high-Z solids

    Energy Technology Data Exchange (ETDEWEB)

    Zhidkov, A.; Sasaki, Akira; Utsumi, Takayuki; Fukumoto, Ichirou; Tajima, Toshiki [Advanced Photon Research Center, Kansai Research Establishment, Japan Atomic Energy Research Institute, Neyagawa, Osaka (Japan); Yoshida, Masatake [National Institute of Material and Chemical Research, Tsukuba, Ibaraki (Japan); Kondo, Kenichi [Materials and Structures Laboratory, Tokyo Institute of Technology, Yokohama, Kanagawa (Japan)

    2000-03-01

    A plasma irradiated by an intense very short pulse laser can be an ultimate high brightness source of incoherent inner-shell X-ray emission of 1-30 keV. The recently developed 100 TW, 20 fs laser facility in JAERI can make considerable enhancement here. To show this a hybrid model combining hydrodynamics and collisional particle-in-cell simulations is applied. Effect of laser prepulse on the interaction of an intense s-polarized femtosecond, {approx}20/40 fs, laser pulse with high-Z solid targets is studied. A new absorption mechanism originating from the interaction of the laser pulse with plasma waves excited by the relativistic component of the Lorentz force is found to increase the absorption rate over 30% even for a very short laser pulse. The obtained hot electron temperature exceeds 0.5-1 MeV at optimal conditions for absorption. Results of the simulation for lower laser pulse intensities are in good agreement with the experimental measurements of the hot electron energy distribution. (author)

  5. Line intensities of the asymptotic asymmetric-top radical HO2 at high temperatures

    Institute of Scientific and Technical Information of China (English)

    Song Xiao-Shu; Cheng Xin-Lu; Yang Xiang-Dong; Linghu Rong-Feng; Lv Sing

    2008-01-01

    The total internal partition sums were calculated in the product approximation at temperatures up to 5000 K for the asymptotic asymmetric-top HO2 molecule.The calculations of the rotational partition function and the vibrational partition function were carried out with the rigid-top model and in the harmonic oscillator approximation,respectively.Our values of the total internal partition sums are consistent with the data of HITRAN database with -0.14% at 296 K.Using the calculated partition functions,we have calculated the line intensities of υ2 band of HO2 at several high temperatures.The results showed that the calculated line intensities are in very good agreement with those of HITRAN database at temperatures up to 3000 K,which provides a strong support for the calculations of partition functions and line intensities at high temperatures.Then we have extended the calculation to higher temperatures.The simulated spectra of u2 band of the asymptotic asymmetric-top HO2 molecule at 4000 and 5000K are also obtained.

  6. Robust intensification of hydroclimatic intensity over East Asia from multi-model ensemble regional projections

    Science.gov (United States)

    Im, Eun-Soon; Choi, Yeon-Woo; Ahn, Joong-Bae

    2017-08-01

    This study assesses the hydroclimatic response to global warming over East Asia from multi-model ensemble regional projections. Four different regional climate models (RCMs), namely, WRF, HadGEM3-RA, RegCM4, and GRIMs, are used for dynamical downscaling of the Hadley Centre Global Environmental Model version 2-Atmosphere and Ocean (HadGEM2-AO) global projections forced by the representative concentration pathway (RCP4.5 and RCP8.5) scenarios. Annual mean precipitation, hydroclimatic intensity index (HY-INT), and wet and dry extreme indices are analyzed to identify the robust behavior of hydroclimatic change in response to enhanced emission scenarios using high-resolution (12.5 km) and long-term (1981-2100) daily precipitation. Ensemble projections exhibit increased hydroclimatic intensity across the entire domain and under both the RCP scenarios. However, a geographical pattern with predominantly intensified HY-INT does not fully emerge in the mean precipitation change because HY-INT is tied to the changes in the precipitation characteristics rather than to those in the precipitation amount. All projections show an enhancement of high intensity precipitation and a reduction of weak intensity precipitation, which lead to a possible shift in hydroclimatic regime prone to an increase of both wet and dry extremes. In general, projections forced by the RCP8.5 scenario tend to produce a much stronger response than do those by the RCP4.5 scenario. However, the temperature increase under the RCP4.5 scenario is sufficiently large to induce significant changes in hydroclimatic intensity, despite the relatively uncertain change in mean precipitation. Likewise, the forced responses of HY-INT and the two extreme indices are more robust than that of mean precipitation, in terms of the statistical significance and model agreement.

  7. Robust intensification of hydroclimatic intensity over East Asia from multi-model ensemble regional projections

    Science.gov (United States)

    Im, Eun-Soon; Choi, Yeon-Woo; Ahn, Joong-Bae

    2016-06-01

    This study assesses the hydroclimatic response to global warming over East Asia from multi-model ensemble regional projections. Four different regional climate models (RCMs), namely, WRF, HadGEM3-RA, RegCM4, and GRIMs, are used for dynamical downscaling of the Hadley Centre Global Environmental Model version 2-Atmosphere and Ocean (HadGEM2-AO) global projections forced by the representative concentration pathway (RCP4.5 and RCP8.5) scenarios. Annual mean precipitation, hydroclimatic intensity index (HY-INT), and wet and dry extreme indices are analyzed to identify the robust behavior of hydroclimatic change in response to enhanced emission scenarios using high-resolution (12.5 km) and long-term (1981-2100) daily precipitation. Ensemble projections exhibit increased hydroclimatic intensity across the entire domain and under both the RCP scenarios. However, a geographical pattern with predominantly intensified HY-INT does not fully emerge in the mean precipitation change because HY-INT is tied to the changes in the precipitation characteristics rather than to those in the precipitation amount. All projections show an enhancement of high intensity precipitation and a reduction of weak intensity precipitation, which lead to a possible shift in hydroclimatic regime prone to an increase of both wet and dry extremes. In general, projections forced by the RCP8.5 scenario tend to produce a much stronger response than do those by the RCP4.5 scenario. However, the temperature increase under the RCP4.5 scenario is sufficiently large to induce significant changes in hydroclimatic intensity, despite the relatively uncertain change in mean precipitation. Likewise, the forced responses of HY-INT and the two extreme indices are more robust than that of mean precipitation, in terms of the statistical significance and model agreement.

  8. High-intensity training reduces CD8+ T-cell redistribution in response to exercise

    NARCIS (Netherlands)

    Witard, O.C.; Turner, J.E.; Jackman, S.R.; Tipton, K.D.; Jeukendrup, A.E.; Kies, A.K.; Bosch, J.A.

    2012-01-01

    Purpose: We examined whether exercise-induced lymphocytosis and lymphocytopenia are impaired with high-intensity training. Methods: Eight trained cyclists (V·O2max = 64.2 ± 6.5 mL·kg-1·min-1) undertook 1 wk of normal-intensity training and a second week of high-intensity training. On day 7 of each w

  9. Efficient Calibration of Computationally Intensive Groundwater Models through Surrogate Modelling with Lower Levels of Fidelity

    Science.gov (United States)

    Razavi, S.; Anderson, D.; Martin, P.; MacMillan, G.; Tolson, B.; Gabriel, C.; Zhang, B.

    2012-12-01

    Many sophisticated groundwater models tend to be computationally intensive as they rigorously represent detailed scientific knowledge about the groundwater systems. Calibration (model inversion), which is a vital step of groundwater model development, can require hundreds or thousands of model evaluations (runs) for different sets of parameters and as such demand prohibitively large computational time and resources. One common strategy to circumvent this computational burden is surrogate modelling which is concerned with developing and utilizing fast-to-run surrogates of the original computationally intensive models (also called fine models). Surrogates can be either based on statistical and data-driven models such as kriging and neural networks or simplified physically-based models with lower fidelity to the original system (also called coarse models). Fidelity in this context refers to the degree of the realism of a simulation model. This research initially investigates different strategies for developing lower-fidelity surrogates of a fine groundwater model and their combinations. These strategies include coarsening the fine model, relaxing the numerical convergence criteria, and simplifying the model geological conceptualisation. Trade-offs between model efficiency and fidelity (accuracy) are of special interest. A methodological framework is developed for coordinating the original fine model with its lower-fidelity surrogates with the objective of efficiently calibrating the parameters of the original model. This framework is capable of mapping the original model parameters to the corresponding surrogate model parameters and also mapping the surrogate model response for the given parameters to the original model response. This framework is general in that it can be used with different optimization and/or uncertainty analysis techniques available for groundwater model calibration and parameter/predictive uncertainty assessment. A real-world computationally

  10. A Dual Aspect Process Model of Intensive Interaction

    Science.gov (United States)

    Firth, Graham

    2009-01-01

    Intensive Interaction is an empirically researched approach to developing fundamental communication and sociability for people with severe and profound learning disabilities and/or autism. However, it is the author's contention that certain aspects of Intensive Interaction are not universally conceptualised in a uniform manner, and that there are…

  11. Modelling Variable Fire Severity in Boreal Forests: Effects of Fire Intensity and Stand Structure.

    Science.gov (United States)

    Miquelajauregui, Yosune; Cumming, Steven G; Gauthier, Sylvie

    2016-01-01

    It is becoming clear that fires in boreal forests are not uniformly stand-replacing. On the contrary, marked variation in fire severity, measured as tree mortality, has been found both within and among individual fires. It is important to understand the conditions under which this variation can arise. We integrated forest sample plot data, tree allometries and historical forest fire records within a diameter class-structured model of 1.0 ha patches of mono-specific black spruce and jack pine stands in northern Québec, Canada. The model accounts for crown fire initiation and vertical spread into the canopy. It uses empirical relations between fire intensity, scorch height, the percent of crown scorched and tree mortality to simulate fire severity, specifically the percent reduction in patch basal area due to fire-caused mortality. A random forest and a regression tree analysis of a large random sample of simulated fires were used to test for an effect of fireline intensity, stand structure, species composition and pyrogeographic regions on resultant severity. Severity increased with intensity and was lower for jack pine stands. The proportion of simulated fires that burned at high severity (e.g. >75% reduction in patch basal area) was 0.80 for black spruce and 0.11 for jack pine. We identified thresholds in intensity below which there was a marked sensitivity of simulated fire severity to stand structure, and to interactions between intensity and structure. We found no evidence for a residual effect of pyrogeographic region on simulated severity, after the effects of stand structure and species composition were accounted for. The model presented here was able to produce variation in fire severity under a range of fire intensity conditions. This suggests that variation in stand structure is one of the factors causing the observed variation in boreal fire severity.

  12. Time Exceedances for High Intensity Solar Proton Fluxes

    Science.gov (United States)

    Xapsos, Michael A.; Stauffer, Craig A.; Jordan, Thomas M.; Adam, James H., Jr.; Dietrich, William F.

    2011-01-01

    A model is presented for times during a space mission that specified solar proton flux levels are exceeded. This includes both total time and continuous time periods during missions. Results for the solar maximum and solar minimum phases of the solar cycle are presented and compared for a broad range of proton energies and shielding levels. This type of approach is more amenable to reliability analysis for spacecraft systems and instrumentation than standard statistical models.

  13. Moderate intensity, but not high intensity, treadmill exercise training alters power output properties in myocardium from aged rats.

    Science.gov (United States)

    Chung, Eunhee; Diffee, Gary M

    2012-11-01

    Aging is characterized by a progressive decline in cardiac function, but endurance exercise training has been shown to retard a number of deleterious effects of aging. However, underlying mechanisms by which exercise training improves age-related decrements in myocardial contractile function are not well understood. The purpose of this study was to determine the effects of exercise training on power output properties in permeablized (skinned) myocytes of old rats. Thirty-month-old rats were divided into sedentary control (C) and groups undergoing 11 weeks of treadmill exercise training at moderate intensity (MI) and at high intensity (HI). Peak power output normalized to maximal force was significantly increased in MI but not in HI compared to C with significant increases in atrial myosin light chain 1 in ventricle. These results suggest that MI exercise training is beneficial as a significant increase was seen in the ability of the myocardium to do work, but this effect was not seen with HI training.

  14. An electron of helium atom under a high-intensity laser field

    Science.gov (United States)

    Falaye, Babatunde James; Sun, Guo-Hua; Adepoju, Adenike Grace; Liman, Muhammed S.; Oyewumi, K. J.; Dong, Shi-Hai

    2017-02-01

    We scrutinize the behavior of eigenvalues of an electron in a helium (He) atom as it interacts with electric field directed along the z-axis and is exposed to linearly polarized intense laser field radiation. To achieve this, we freeze one electron of the He atom at its ionic ground state and the motion of the second electron in the ion core is treated via a more general case of screened Coulomb potential model. Using the Kramers-Henneberger (KH) unitary transformation, which is the semiclassical counterpart of the Block-Nordsieck transformation in the quantized field formalism, the squared vector potential that appears in the equation of motion is eliminated and the resultant equation is expressed in the KH frame. Within this frame, the resulting potential and the corresponding wave function are expanded in Fourier series and using Ehlotzky’s approximation, we obtain a laser-dressed potential to simulate intense laser field. By fitting the more general case of screened Coulomb potential model into the laser-dressed potential, and then expanding it in Taylor series up to O≤ft({{r}4},α 09\\right) , we obtain the solution (eigenvalues and wave function) of an electron in a He atom under the influence of external electric field and high-intensity laser field, within the framework of perturbation theory formalism. We found that the variation in frequency of laser radiation has no effect on the eigenvalues of a He electron for a particular electric field intensity directed along z-axis. Also, for a very strong external electric field and an infinitesimal screening parameter, the system is strongly bound. This work has potential application in the areas of atomic and molecular processes in external fields including interactions with strong fields and short pulses.

  15. Metabolic responses to high protein diet in Korean elite bodybuilders with high-intensity resistance exercise

    Directory of Open Access Journals (Sweden)

    Choue Ryowon

    2011-07-01

    Full Text Available Abstract Background High protein diet has been known to cause metabolic acidosis, which is manifested by increased urinary excretion of nitrogen and calcium. Bodybuilders habitually consumed excessive dietary protein over the amounts recommended for them to promote muscle mass accretion. This study investigated the metabolic response to high protein consumption in the elite bodybuilders. Methods Eight elite Korean bodybuilders within the age from 18 to 25, mean age 21.5 ± 2.6. For data collection, anthropometry, blood and urinary analysis, and dietary assessment were conducted. Results They consumed large amounts of protein (4.3 ± 1.2 g/kg BW/day and calories (5,621.7 ± 1,354.7 kcal/day, as well as more than the recommended amounts of vitamins and minerals, including potassium and calcium. Serum creatinine (1.3 ± 0.1 mg/dl and potassium (5.9 ± 0.8 mmol/L, and urinary urea nitrogen (24.7 ± 9.5 mg/dl and creatinine (2.3 ± 0.7 mg/dl were observed to be higher than the normal reference ranges. Urinary calcium (0.3 ± 0.1 mg/dl, and phosphorus (1.3 ± 0.4 mg/dl were on the border of upper limit of the reference range and the urine pH was in normal range. Conclusions Increased urinary excretion of urea nitrogen and creatinine might be due to the high rates of protein metabolism that follow high protein intake and muscle turnover. The obvious evidence of metabolic acidosis in response to high protein diet in the subjects with high potassium intake and intensive resistance exercise were not shown in this study results. However, this study implied that resistance exercise with adequate mineral supplementation, such as potassium and calcium, could reduce or offset the negative effects of protein-generated metabolic changes. This study provides preliminary information of metabolic response to high protein intake in bodybuilders who engaged in high-intensity resistance exercise. Further studies will be needed to determine the effects of the intensity

  16. [Reflected high-intensity motion signals as markers of left ventricular diastolic dysfunction].

    Science.gov (United States)

    Makarenko, E S

    2013-01-01

    Reflected high-intensity signals of left ventricular motion can be used for assessment of diastolic function of left ventricle. There are many correlations between reflected high-intensity signals, transmitral flow, and tissue Doppler imaging parameters. Diagnostic criteria of LV diastolic dysfunction based on measurement of LV motion are suggested.

  17. The influence of basketball dribbling on repeated high-intensity intermittent runs

    Directory of Open Access Journals (Sweden)

    Zhaowei Kong

    2015-12-01

    Conclusion: The results suggest that the Yo-Yo IE2 test could reflect the repeatability of high-intensity intermittent basketball dribbling performance, while dribbling skills may have different influences on high-intensity intermittent exercise capacity in adolescent players at different ages.

  18. Refinement of Eutectic Silicon Phase of Aluminum A356 Alloy Using High-Intensity Ultrasonic Vibration

    Energy Technology Data Exchange (ETDEWEB)

    Jian, Xiaogang [ORNL; Han, Qingyou [ORNL

    2006-01-01

    The eutectic silicon in A356 alloy can be refined and modified using either chemical, quench, or superheating modification. We observed, for the first time, that the eutectic silicon can also be significantly refined using high-intensity ultrasonic vibration. Rosette-like eutectic silicon is formed during solidification of specimen treated with high-intensity ultrasonic vibration.

  19. Intensity-specific leisure-time physical activity and the built environment among Brazilian adults: a best-fit model.

    Science.gov (United States)

    Salvo, Deborah; Reis, Rodrigo S; Hino, Adriano A F; Hallal, Pedro C; Pratt, Michael

    2015-03-01

    There is little understanding about which sets of environmental features could simultaneously predict intensity-specific leisure-time physical activity (LTPA) among Brazilians. The objectives were to identify the environmental correlates for intensity-specific LTPA, and to build the best-fit linear models to predict intensity-specific LTPA among adults of Curitiba, Brazil. Cross sectional study in Curitiba, Brazil (2009, n = 1461). The International Physical Activity Questionnaire and Abbreviated Neighborhood Environment Assessment Scale were used. Ninety-two perceived environment variables were categorized in 10 domains. LTPA was classified as walking for leisure (LWLK), moderate-intensity leisure-time PA (MLPA), vigorous-intensity leisure-time PA (VLPA), and moderate-to-vigorous intensity leisure-time PA (MVLPA). Best fitting linear predictive models were built. Forty environmental variables were correlated to at least 1 LTPA outcome. The variability explained by the 4 best-fit models ranged from 17% (MLPA) to 46% (MVLPA). All models contained recreation areas and aesthetics variables; none included residential density predictors. At least 1 neighborhood satisfaction variable was present in each of the intensity-specific models, but not for overall MVLPA. This study demonstrates the simultaneous effect of sets of perceived environmental features on intensity-specific LTPA among Brazilian adults. The differences found compared with high-income countries suggest caution in generalizing results across settings.

  20. The study towards high intensity high charge state laser ion sources.

    Science.gov (United States)

    Zhao, H Y; Jin, Q Y; Sha, S; Zhang, J J; Li, Z M; Liu, W; Sun, L T; Zhang, X Z; Zhao, H W

    2014-02-01

    As one of the candidate ion sources for a planned project, the High Intensity heavy-ion Accelerator Facility, a laser ion source has been being intensively studied at the Institute of Modern Physics in the past two years. The charge state distributions of ions produced by irradiating a pulsed 3 J/8 ns Nd:YAG laser on solid targets of a wide range of elements (C, Al, Ti, Ni, Ag, Ta, and Pb) were measured with an electrostatic ion analyzer spectrometer, which indicates that highly charged ions could be generated from low-to-medium mass elements with the present laser system, while the charge state distributions for high mass elements were relatively low. The shot-to-shot stability of ion pulses was monitored with a Faraday cup for carbon target. The fluctuations within ±2.5% for the peak current and total charge and ±6% for pulse duration were demonstrated with the present setup of the laser ion source, the suppression of which is still possible.

  1. The study towards high intensity high charge state laser ion sources

    Science.gov (United States)

    Zhao, H. Y.; Jin, Q. Y.; Sha, S.; Zhang, J. J.; Li, Z. M.; Liu, W.; Sun, L. T.; Zhang, X. Z.; Zhao, H. W.

    2014-02-01

    As one of the candidate ion sources for a planned project, the High Intensity heavy-ion Accelerator Facility, a laser ion source has been being intensively studied at the Institute of Modern Physics in the past two years. The charge state distributions of ions produced by irradiating a pulsed 3 J/8 ns Nd:YAG laser on solid targets of a wide range of elements (C, Al, Ti, Ni, Ag, Ta, and Pb) were measured with an electrostatic ion analyzer spectrometer, which indicates that highly charged ions could be generated from low-to-medium mass elements with the present laser system, while the charge state distributions for high mass elements were relatively low. The shot-to-shot stability of ion pulses was monitored with a Faraday cup for carbon target. The fluctuations within ±2.5% for the peak current and total charge and ±6% for pulse duration were demonstrated with the present setup of the laser ion source, the suppression of which is still possible.

  2. Multipass relativistic high-order-harmonic generation for intense attosecond pulses

    Science.gov (United States)

    Edwards, Matthew R.; Mikhailova, Julia M.

    2016-02-01

    We demonstrate that the total reflected field produced by the interaction of a moderately relativistic laser with dense plasma is itself an efficient driver of high-order-harmonic generation. A system of two or more successive interactions of an incident laser beam on solid targets may therefore be an experimentally realizable method of optimizing conversion of laser energy to high-order harmonics. Particle-in-cell simulations suggest that attosecond pulse intensity may be increased by up to four orders of magnitude in a multipass system, with decreased duration of the attosecond pulse train. We discuss high-order-harmonic wave-form engineering for enhanced attosecond pulse generation with an electron trajectory model, present the behavior of multipass systems over a range of parameters, and offer possible routes towards experimental implementation of a two-pass system.

  3. Simulation of high-intensity focused ultrasound lesions in presence of boiling.

    Science.gov (United States)

    Grisey, Anthony; Yon, Sylvain; Letort, Véronique; Lafitte, Pauline

    2016-01-01

    The lesions induced by high-intensity focused ultrasound (HIFU) thermal ablations are particularly difficult to simulate due to the complexity of the involved phenomena. In particular, boiling has a strong influence on the lesion shape. Thus, it must be accounted for if it happens during the pulses to be modeled. However, no acoustic model enables the simulation of the resulting wave scattering. Therefore, we propose an equivalent model for the heat deposition pattern in the presence of boiling. Firstly, the acoustic field is simulated with k-Wave and the heat source term is calculated. Then, a thermal model is designed, including the equivalent model for boiling. It is rigorously calibrated and validated through the use of diversified ex vivo and in vivo data, including usually unexploited data types related to the bubble clouds. The proposed model enabled to efficiently simulate unitary pulses properties, including the sizes of the lesions, their morphology, the boiling onset time, and the influence of the boiling onset time on the lesions sizes. In this article, the whole procedure of model design, calibration, and validation is discussed. In addition to depicting the creative use of data, our modeling approach focuses on the understanding of the mechanisms influencing the shape of the lesion. Further work is required to study the influence of the remaining bubble clouds in the context of pulse groups.

  4. COLLIMATORS AND MATERIALS FOR HIGH INTENSITY HEAVY ION SYNCHROTRONS

    CERN Document Server

    Stadlmann, J; Kollmus, H; Spiller, P; Strasik, I; Tahir, N A; Tomut, M; Trautmann, C

    2012-01-01

    The operation of high power high brightness accelerators requires huge efforts for beam cleaning and machine protection. Within the WP 8 (ColMat) of the EU research framework EuCARD[1] we investigate new materials and methods for beam collimation and machine protection. We present an overview of these activities at the GSI Helmholtzzentrum f¨ur Schwerionenforschung, Darmstadt. Simulations of accidental beam losses in LHC and SIS100 have been performed. Scenarios for halo collimation of heavy ions and protons in SIS100 routine operation have been investigated. A prototype of a cryogenic collimator for charge exchange losses during intermediate charge state heavy ion operation in SIS100 has been build and tested with beam. Several candidates of advanced composite materials for collimation system upgrades of present and future high power accelerators have been irradiated and their properties are being characterized. Most deliverables and milestones of the R&D programme were already reached before the end of...

  5. Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

    DEFF Research Database (Denmark)

    Babraj, John A; Vollaard, Niels B J; Keast, Cameron

    2009-01-01

    BACKGROUND: Traditional high volume aerobic exercise training reduces cardiovascular and metabolic disease risk but involves a substantial time commitment. Extremely low volume high-intensity interval training (HIT) has recently been demonstrated to produce improvements to aerobic function, but i...

  6. Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney

    CERN Document Server

    Suomi, Visa; Treeby, Bradley; Cleveland, Robin

    2016-01-01

    Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney. The combined effect of inhomogeneous attenuation and sound-speed was found to result in an 11.0 dB drop in spatial peak-temporal average (SPTA) intensity in the kidney compared to pure water. The simulation without refraction effects showed a 6.3 dB decrease indicating that both attenuation and refraction contribute to the loss in focal intensity. The losses due to reflections at soft tissue interfaces were less than 0....

  7. High intensity electromagnetic field gerenation using a transportable reverberation chamber

    NARCIS (Netherlands)

    Leferink, Frank

    2008-01-01

    A reverberation chamber can create very high field strength with moderate input power. Existing chambers are making use of a paddle wheel to change the resonant modes in the chamber. A transportable reverberation chamber with vibrating walls will be presented. Inside this Vibrating Intrinsic Reverbe

  8. Modeling the Distribution of Rainfall Intensity using Hourly Data

    OpenAIRE

    Salisu Dan'azumi; Supiah Shamsudin; Azmi Aris

    2010-01-01

    Problem statement: Design of storm water best management practices to control runoff and water pollution can be achieved if a prior knowledge of the distribution of rainfall characteristics is known. Rainfall intensity, particularly in tropical climate, plays a major role in the design of runoff conveyance and erosion control systems. This study is aimed to explore the statistical distribution of rainfall intensity for Peninsular Malaysia using hourly rainfall data. Approach: Hourly rainfall ...

  9. STATUS REPORT ON DEVELOPMENT OF A HIGH-SPEED HIGH-INTENSITY MOLECULAR BEAM

    Energy Technology Data Exchange (ETDEWEB)

    Knuth, Eldon L.

    1963-07-15

    Status of a high-speed high-intensity molecular beam under development is described. Bases for designs of the several components are presented. Using an arc-heated source and a hypersonic jet, molecular energies exceeding 1 ev and beam intensities of the order of 10/sup 16/ molecules/ cm/sup 2/ sec are anticipated. A two-disk beam chopper and speed selector provides a means for analyzing the speed distribution in the generated beam, for chopping the beam into bursts of nearly monoenergetic molecules suitable for scattering studies using the time-of-flight technique, and for modulating the beam in order to facilitate detection. A through-flow ionization detector possesses the versatility required for scattering studies using the time-of-flight technique. A sorption pump and a turbo pump serve as central components of alternative pumping systems for the collimating chamber. Using the arc-heated source, the converging nozzle, the conduction-radiation-cooled skimmer, the turbo pump (turning at 3400 rpm), the chopperselector (acting only as a chopper), and the detector, an arc-heated beam is generated and detected. (auth)

  10. Intense high-quality medical proton beams via laser fields

    CERN Document Server

    Galow, Benjamin J; Keitel, Christoph H

    2010-01-01

    Simulations based on the coupled relativistic equations of motion show that protons stemming from laserplasma processes can be efficiently post-accelerated employing crossed pulsed laser beams focused to spot radii on the order of the laser wavelength. We demonstrate that the crossed beams produce quasi-monoenergetic accelerated protons with kinetic energies exceeding 200 MeV, small energy spreads of about 1% and high densities as required for hadron cancer therapy.

  11. High-intensity molecular harmonic generation without ionization

    Institute of Scientific and Technical Information of China (English)

    Wang Jun; Chen Gao; Guo Fu-Ming; Li Su-Yu; Chen Ji-Gen; Yang Yu-Jun

    2013-01-01

    We theoretically investigate high-order harmonic generation from H2+ in an infrared laser field.Our numerical simulations show that a highly efficient plateau structure exists in the molecular harmonic spectrum.Under the action of the infrared laser pulse,the bound electronic wave packet in a potential well has enough time to tunnel through the effective potential barrier,which is formed by the molecular potential and the infrared laser field,and then recombine with the neighboring nucleus emitting a harmonic photon.During the entire dynamic process,because the wave packet is mainly located in the effective potential,the diffusion effect is of no significance,and thus a highly efficient harmonic plateau can be achieved.Specifically,the cut-off frequency of the plateau is linearly scaled with the peak amplitude of the infrared laser electric field,which may open another route to examine the internuclear distance of the molecule.Furthermore,one may detect the molecular bond lengths using the harmonic plateau.

  12. A Highly intense DC muon source, MuSIC and muon CLFV search

    Science.gov (United States)

    Hino, Y.; Kuno, Y.; Sato, A.; Sakamoto, H.; Matsumoto, Y.; Tran, N. H.; Hashim, I. H.; Fukuda, M.; Hayashida, Y.; Ogitsu, T.; Yamamoto, A.; Yoshida, M.

    2014-08-01

    MuSIC is a new muon facility, which provides the world's highest intense muon beam with continuous time structure at Research Center of Nuclear Physics (RCNP), Osaka University. It's intensity is designed to be 108 muons per second with only 0.4 kW proton beam. Such a high intense muon beam is very important for searches of rare decay processes, for example search for the muon to electron conversion.

  13. A Highly intense DC muon source, MuSIC and muon CLFV search

    Energy Technology Data Exchange (ETDEWEB)

    Hino, Y.; Kuno, Y.; Sato, A. [Department of Physics, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Sakamoto, H. [Department of Physics, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Research Center of Nuclear Physics, 10-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Matsumoto, Y.; Tran, N.H.; Hashim, I.H. [Department of Physics, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Fukuda, M.; Hayashida, Y. [Research Center of Nuclear Physics, 10-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Ogitsu, T.; Yamamoto, A.; Yoshida, M. [High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)

    2014-08-15

    MuSIC is a new muon facility, which provides the world's highest intense muon beam with continuous time structure at Research Center of Nuclear Physics (RCNP), Osaka University. It's intensity is designed to be 10{sup 8} muons per second with only 0.4 kW proton beam. Such a high intense muon beam is very important for searches of rare decay processes, for example search for the muon to electron conversion.

  14. Complex Data Modeling and Computationally Intensive Statistical Methods

    CERN Document Server

    Mantovan, Pietro

    2010-01-01

    The last years have seen the advent and development of many devices able to record and store an always increasing amount of complex and high dimensional data; 3D images generated by medical scanners or satellite remote sensing, DNA microarrays, real time financial data, system control datasets. The analysis of this data poses new challenging problems and requires the development of novel statistical models and computational methods, fueling many fascinating and fast growing research areas of modern statistics. The book offers a wide variety of statistical methods and is addressed to statistici

  15. High-intensity drying processes-impulse drying

    Energy Technology Data Exchange (ETDEWEB)

    Orloff, D.I.

    1991-06-01

    Impulse drying is an innovative process for drying paper that holds great promise for reducing the energy consumed during the manufacture of paper and similar web products. impulse drying occurs when a wet paper web passes through a press nip in which one of the rolls is heated to a high temperature. A steam layer adjacent to the heated surface grows and displaces water from the sheet in a very efficient manner. The energy required for water removal is very much less than that required for conventional evaporative drying. To eliminate sheet delamination, low thermal mass ceramic press roll coatings were developed to reduce heat transfer to the sheet, while maintaining high heat flux during early stages of the process. In so doing, most of the transferred energy is used to form steam that displaces liquid water, rather than in excessively heating the sheet. During this period, a prototype ceramic coating was developed and its impulse drying performance was compared to that of steel surfaces. It was observed that ceramic platens can be operated at higher temperatures and pressures resulting in improved water removal and physical properties without inducing sheet delamination. Heat flux measurement techniques were developed to provide a mechanistic explanation for the superior performance of the prototype. The work confirmed that the prototype ceramic coating is more energy efficient than the steel surface.

  16. High-intensity drying processes-impulse drying. Yearly report

    Energy Technology Data Exchange (ETDEWEB)

    Orloff, D.I.

    1991-06-01

    Impulse drying is an innovative process for drying paper that holds great promise for reducing the energy consumed during the manufacture of paper and similar web products. impulse drying occurs when a wet paper web passes through a press nip in which one of the rolls is heated to a high temperature. A steam layer adjacent to the heated surface grows and displaces water from the sheet in a very efficient manner. The energy required for water removal is very much less than that required for conventional evaporative drying. To eliminate sheet delamination, low thermal mass ceramic press roll coatings were developed to reduce heat transfer to the sheet, while maintaining high heat flux during early stages of the process. In so doing, most of the transferred energy is used to form steam that displaces liquid water, rather than in excessively heating the sheet. During this period, a prototype ceramic coating was developed and its impulse drying performance was compared to that of steel surfaces. It was observed that ceramic platens can be operated at higher temperatures and pressures resulting in improved water removal and physical properties without inducing sheet delamination. Heat flux measurement techniques were developed to provide a mechanistic explanation for the superior performance of the prototype. The work confirmed that the prototype ceramic coating is more energy efficient than the steel surface.

  17. Data Intensive High Energy Physics Analysis in a Distributed Cloud

    CERN Document Server

    Sobie, R J; Anderson, M; Armstrong, P; Fransham, K; Gable, I; Harris, D; Leavett-Brown, C; Paterson, M; Penfold-Brown, D; Vliet, M; Charbonneau, A; Impey, R; Podaima, W

    2011-01-01

    We show that distributed Infrastructure-as-a-Service (IaaS) compute clouds can be effectively used for the analysis of high energy physics data. We have designed a distributed cloud system that works with any application using large input data sets requiring a high throughput computing environment. The system uses IaaS-enabled science and commercial clusters in Canada and the United States. We describe the process in which a user prepares an analysis virtual machine (VM) and submits batch jobs to a central scheduler. The system boots the user-specific VM on one of the IaaS clouds, runs the jobs and returns the output to the user. The user application accesses a central database for calibration data during the execution of the application. Similarly, the data is located in a central location and streamed by the running application. The system can easily run one hundred simultaneous jobs in an efficient manner and should scale to many hundreds and possibly thousands of user jobs.

  18. Relative Match Intensities at High Altitude in Highly-Trained Young Soccer Players (ISA3600

    Directory of Open Access Journals (Sweden)

    Martin Buchheit

    2015-03-01

    Full Text Available To compare relative match intensities of sea-level versus high-altitude native soccer players during a 2-week camp at 3600 m, data from 7 sea-level (Australian U17 National team, AUS and 6 high-altitude (a Bolivian U18 team, BOL native soccer players were analysed. Two matches were played at sea-level and three at 3600 m on Days 1, 6 and 13. The Yo-Yo Intermittent recovery test (vYo-YoIR1 was performed at sea-level, and on Days 3 and 10. Match activity profiles were measured via 10-Hz GPS. Distance covered >14.4 km.h-1 (D>14.4 km·h-1 and >80% of vYo-YoIR1 (D>80%vYo-YoIR1 were examined. Upon arrival at altitude, there was a greater decrement in vYo-YoIR1 (Cohen’s d +1.0, 90%CL ± 0.8 and D>14.4 km·h-1 (+0.5 ± 0.8 in AUS. D>14.4 km.h-1 was similarly reduced relative to vYo-YoIR1 in both groups, so that D>80%vYo-YoIR1 remained similarly unchanged (-0.1 ± 0.8. Throughout the altitude sojourn, vYo-YoIR1 and D>14.4 km·h-1 increased in parallel in AUS, so that D>80%vYo-YoIR1 remained stable in AUS (+6.0%/match, 90%CL ± 6.7; conversely D>80%vYo-YoIR1 decreased largely in BOL (-12.2%/match ± 6.2. In sea-level natives competing at high-altitude, changes in match running performance likely follow those in high-intensity running performance. Bolivian data confirm that increases in ‘fitness’ do not necessarily translate into greater match running performance, but rather in reduced relative exercise intensity.

  19. EFFECT OF HIGH & LOW INTENSITIES OF AEROBIC EXERCISE ON PHYSICAL FITNESS INDEX

    Directory of Open Access Journals (Sweden)

    Madhusudhan

    2015-06-01

    Full Text Available BACKGROUND: Aerobic exercise reduces body fat and improves weight control, increases HDL&Vo2 max. Also improves PFI (physical fitness index which is defined as ability to carry out daily tasks with vigour and alertness without undue fatigue. Though aerobic exercise is found to improve physical fitness, the relative merits of different intensities of aerobi c exercise in improving physical fitness is still uncertain. AIM: The present study was conducted to know the Effect of High & low intensity aerobic training on physical fitness index. MATERIALS & METHODS : 80 sedentary men (18 - 40 years were randomized in to 2 equal groups (High Intensity & low intensity group . The High [80% HR max] & Low intensity [50 % HR max] groups underwent aerobic exercise training using Bicycle ergo meter (COSCO at 900kpm & 540kpm, for 15mins/day & 30mins/day respectively, 5days a week, for a period of 14weeks. Physical fitness index of each subject was recorded by Modified Harvard step test before & after intervention. RESULTS : After 14 weeks of aerobic training both the exercise groups had improvement in PFI, but high intensity gr oup had a significant (p<0.05 improvement in PFI (97.18 - 101.14 than low intensity group (98.12 - 100.6. CONCLUSION : High intensity aerobic exercise is effective in improving physical fitness.

  20. Effect of acoustic streaming on tissue heating due to high-intensity focused ultrasound

    CERN Document Server

    Solovchuk, Maxim A; Thiriet, Marc; Lin, Win-Li

    2011-01-01

    The influences of blood vessels and focused location on temperature distribution during high-intensity focused ultrasound (HIFU) ablation of liver tumors is studied. A three-dimensional acoustics-thermal-fluid coupling model is employed to compute the temperature field in the hepatic cancerous region. The model is based on the linear Westervelt and bioheat equations as well as the nonlinear Navier-Stokes equations for the liver parenchyma and blood vessels. The effect of acoustic streaming is also taken into account in the present HIFU simulation study. Different blood vessel diameters and focal point locations were investigated. We found from this three-dimensional numerical study that in large blood vessels both the convective cooling and acoustic streaming can change considerably the temperature field and the thermal lesion near blood vessels. If the blood vessel is located within the beam width, both acoustic streaming and blood flow cooling effects should be taken into account. The predicted temperature ...

  1. High-protein diet induces oxidative stress in rat brain: protective action of high-intensity exercise against lipid peroxidation

    OpenAIRE

    Camiletti-Moir??n, Daniel; Aparicio Garc??a-Molina, Virginia A.; Nebot Valenzuela, Elena; Medina, Gerardo; Mart??nez, Rosario; Kapravelou, Garyfallia; Andrade, Ana; Porres-Foulquie, Jes??s; L??pez-Jurado, Mar??a; Aranda Ram??rez, Pilar

    2015-01-01

    diets as well as aerobic exercise could promote antioxidant capacity and consequently reduce free radicals overproduction on brain. However, little is know regarding to the high-protein diets and high intensity exercise on oxidative stress production. The aim of this study was to analyse the effects of high-protein diets and high-intensity exercise (HIE) on brain oxidative stress markers. Materials and Methods: A total of 40 male Wistar rats were randomly distributed i...

  2. Generating long sequences of high-intensity femtosecond pulses

    CERN Document Server

    Bitter, Martin

    2015-01-01

    We present an approach to create pulse sequences extending beyond 150~picoseconds in duration, comprised of $100~\\mu$J femtosecond pulses. A quarter of the pulse train is produced by a high-resolution pulse shaper, which allows full controllability over the timing of each pulse. Two nested Michelson interferometers follow to quadruple the pulse number and the sequence duration. To boost the pulse energy, the long train is sent through a multi-pass Ti:Sapphire amplifier, followed by an external compressor. A periodic sequence of 84~pulses of 120~fs width and an average pulse energy of 107~$\\mu$J, separated by 2~ps, is demonstrated as a proof of principle.

  3. Study of a final focus system for high intensity beams

    Energy Technology Data Exchange (ETDEWEB)

    Henestroza, Enrique; Eylon, Shmuel; Roy, Prabir K.; Yu, Simon S.; Bieniosek, Frank M.; Shuman, Derek B.; Waldron, William L.

    2004-06-01

    The NTX experiment at the Heavy Ion Fusion Virtual National Laboratory is exploring the performance of neutralized final focus systems for high perveance heavy ion beams. The final focus scenario in an HIF driver consists of several large aperture quadrupole magnets followed by a drift section in which the beam space charge is neutralized by a plasma. This beam is required to hit a millimeter-sized target spot at the end of the drift section. The objective of the NTX experiments and associated theory and simulations is to study the various physical mechanisms that determine the final spot size (radius r{sub s}) at a given distance (f) from the end of the last quadrupole. In a fusion driver, f is the standoff distance required to keep the chamber wall and superconducting magnets properly protected. The NTX final quadrupole focusing system produces a converging beam at the entrance to the neutralized drift section where it focuses to a small spot. The final spot is determined by the conditions of the beam entering the quadrupole section, the beam dynamics in the magnetic lattice, and the plasma neutralization dynamics in the drift section. The main issues are the control of emittance growth due to high order fields from magnetic multipoles and image fields. In this paper, we will describe the theoretical and experimental aspects of the beam dynamics in the quadrupole lattice, and how these physical effects influence the final beam size. In particular, we present theoretical and experimental results on the dependence of final spot size on geometric aberrations and perveance.

  4. Effect of preseason concurrent muscular strength and high-intensity interval training in professional soccer players.

    Science.gov (United States)

    Wong, Pui-lam; Chaouachi, Anis; Chamari, Karim; Dellal, Alexandre; Wisloff, Ulrik

    2010-03-01

    This study examined the effect of concurrent muscular strength and high-intensity running interval training on professional soccer players' explosive performances and aerobic endurance. Thirty-nine players participated in the study, where both the experimental group (EG, n = 20) and control group (CG, n = 19) participated in 8 weeks of regular soccer training, with the EG receiving additional muscular strength and high-intensity interval training twice per week throughout. Muscular strength training consisted of 4 sets of 6RM (repetition maximum) of high-pull, jump squat, bench press, back half squat, and chin-up exercises. The high-intensity interval training consisted of 16 intervals each of 15-second sprints at 120% of individual maximal aerobic speed interspersed with 15 seconds of rest. EG significantly increased (p aerobic speed test, and maximal aerobic speed. High-intensity interval running can be concurrently performed with high load muscular strength training to enhance soccer players' explosive performances and aerobic endurance.

  5. Improvement of high-voltage staircase drive circuit waveform for high-intensity therapeutic ultrasound

    Science.gov (United States)

    Tamano, Satoshi; Jimbo, Hayato; Azuma, Takashi; Yoshizawa, Shin; Fujiwara, Keisuke; Itani, Kazunori; Umemura, Shin-Ichiro

    2016-07-01

    Recently, in the treatment of diseases such as cancer, noninvasive or low-invasive modality, such as high-intensity focused ultrasound (HIFU), has been put into practice as an alternative to open surgery. HIFU induces thermal ablation of the target tissue to be treated. To improve the efficiency of HIFU, we have proposed a “triggered-HIFU” technique, which uses the combination of a short-duration, high-voltage transmission and a long-duration, medium-voltage transmission. In this method, the transmission device must endure high peak voltage for the former and the high time-average power for the latter. The triggered-HIFU sequence requires electronic scanning of the HIFU focus to maximize its thermal efficiency. Therefore, the transmission device must drive an array transducer with the number of elements on the order of a hundred or more, which requires that each part of the device that drives each element must be compact. The purpose of this work is to propose and construct such a transmission device by improving the staircase drive circuit, which we previously proposed. The main point of improvement is that both N and P MOSFETs are provided for each staircase voltage level instead of only one of them. Compared with the previous ultrasonic transmission circuit, high-voltage spikes were significantly reduced, the power consumption was decreased by 26.7%, and the transmission circuit temperature rise was decreased by 14.5 °C in the triggered-HIFU heating mode.

  6. Dynamics of self-generated, large amplitude magnetic fields following high-intensity laser matter interaction

    CERN Document Server

    Sarri, G; Cecchetti, C A; Kar, S; Liseykina, T V; Yang, X H; Dieckmann, M E; Fuchs, J; Galimberti, M; Gizzi, L A; Jung, R; Kourakis, I; Osterholz, J; Pegoraro, F; Robinson, A P L; Romagnani, L; Willi, O; Borghesi, M

    2012-01-01

    The dynamics of magnetic fields with amplitude of several tens of Megagauss, generated at both sides of a solid target irradiated with a high intensity (? 1019W/cm2) picosecond laser pulse, has been spatially and temporally resolved using a proton imaging technique. The amplitude of the magnetic fields is sufficiently large to have a constraining effect on the radial expansion of the plasma sheath at the target surfaces. These results, supported by numerical simulations and simple analytical modeling, may have implications for ion acceleration driven by the plasma sheath at the rear side of the target as well as for the laboratory study of self-collimated high-energy plasma jets.

  7. High-intensity intermittent swimming improves cardiovascular health status for women with mild hypertension

    DEFF Research Database (Denmark)

    Mohr, Magni; Nordsborg, Nikolai Baastrup; Lindenskov, Annika;

    2014-01-01

    To test the hypothesis that high-intensity swim training improves cardiovascular health status in sedentary premenopausal women with mild hypertension, sixty-two women were randomized into high-intensity (n = 21; HIT), moderate-intensity (n = 21; MOD), and control groups (n = 20; CON). HIT...... performed 6-10 × 30 s all-out swimming interspersed by 2 min recovery and MOD swam continuously for 1 h at moderate intensity for a 15-week period completing in total 44 ± 1 and 43 ± 1 sessions, respectively. In CON, all measured variables were similar before and after the intervention period. Systolic BP...... swim (13 ± 3% and 22 ± 3%), interval swimming (23 ± 3% and 8 ± 3%), and Yo-Yo IE1 running performance (58 ± 5% and 45 ± 4%). In conclusion, high-intensity intermittent swimming is an effective training strategy to improve cardiovascular health and physical performance...

  8. Effect of high-intensity training on endothelial function in patients with cardiovascular and cerebrovascular disease

    DEFF Research Database (Denmark)

    Kolmos, Mia; Krawcyk, Rikke Steen; Kruuse, Christina

    2016-01-01

    OBJECTIVES: Exercise improves endothelial dysfunction, the key manifestation of cardiovascular and cerebrovascular disease, and is recommended in both cardiovascular and cerebrovascular rehabilitation. Disagreement remains, however, on the role of intensity of exercise. The purpose of this review...... was to gather current knowledge on the effects of high-intensity training versus moderate-intensity continuous exercise on endothelial function in cardiovascular and cerebrovascular patients. METHODS: A systematic review was performed in PubMed database, Embase and Cochrane libraries and on PEDro using...... the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were restricted to cardiovascular and cerebrovascular patients, and healthy subjects as general reference. Interventions comprised of high-intensity training alone, high-intensity training compared to moderate...

  9. Treatment of human neurogliocytoma of in a nude mouse model using high intensity focused ultrasound%高强度聚焦超声对裸鼠皮下人胶质瘤的治疗作用

    Institute of Scientific and Technical Information of China (English)

    肖文峰; 霍钢; 郑履平; 唐文渊; 孙晓川; 支兴刚; 李发琪

    2008-01-01

    目的 通过研究高强度聚焦超声(high intensity focused ultrasound,HIFU)对裸鼠皮下人胶质瘤模型作用后的病理转归,探讨其治疗胶质瘤的有效性和安全性.方法 选取24只裸鼠,建立裸鼠皮下人胶质瘤模型,随机分为对照组和实验组.用频率9.7 MHz,焦距4.5 mm,声强2500 W/cm2的HIFU连续作用20 s,于急性期(<3 d)、亚急性期(4~14 d)、慢性期(15~30 d)观察各组肿瘤的生长情况;行2,3,5一三苯基氯化四氮唑(triphenyl tetrazolium choloride,TYC)染色、组织学切片及电镜检查.结果 24只裸鼠全部成瘤,接种20 d后肿瘤体积为(166.56±9.23)mm3,在HIFU作用7 d后,实验组肿瘤体积倍增时间(tumor volume doubling time,TD)与对照组差异有统计学意义(P<0.05).TTC染色显示胶质瘤的生物学焦域为(66.12±2.52)mm3.HE染色示照射区即刻就发生凝固性坏死,并随观察时间的延长坏死越明显;在亚急性期和慢性期可以观察到明显的交界区形成,且在照射区、交界区之间形成锐利的边界.电镜示细胞超微结构出现典型的凝固性坏死改变.结论 在本试验设定参数及声学剂量情况下,HIFU能够准确、完全杀灭照射区胶质瘤,有望成为治疗胶质瘤的新途径.

  10. Short-term effects of implemented high intensity shoulder elevation during computer work

    Directory of Open Access Journals (Sweden)

    Madeleine Pascal

    2009-08-01

    Full Text Available Abstract Background Work-site strength training sessions are shown effective to prevent and reduce neck-shoulder pain in computer workers, but difficult to integrate in normal working routines. A solution for avoiding neck-shoulder pain during computer work may be to implement high intensity voluntary contractions during the computer work. However, it is unknown how this may influence productivity, rate of perceived exertion (RPE as well as activity and rest of neck-shoulder muscles during computer work. The aim of this study was to investigate short-term effects of a high intensity contraction on productivity, RPE and upper trapezius activity and rest during computer work and a subsequent pause from computer work. Methods 18 female computer workers performed 2 sessions of 15 min standardized computer mouse work preceded by 1 min pause with and without prior high intensity contraction of shoulder elevation. RPE was reported, productivity (drawings per min measured, and bipolar surface electromyography (EMG recorded from the dominant upper trapezius during pauses and sessions of computer work. Repeated measure ANOVA with Bonferroni corrected post-hoc tests was applied for the statistical analyses. Results The main findings were that a high intensity shoulder elevation did not modify RPE, productivity or EMG activity of the upper trapezius during the subsequent pause and computer work. However, the high intensity contraction reduced the relative rest time of the uppermost (clavicular trapezius part during the subsequent pause from computer work (p Conclusion Since a preceding high intensity shoulder elevation did not impose a negative impact on perceived effort, productivity or upper trapezius activity during computer work, implementation of high intensity contraction during computer work to prevent neck-shoulder pain may be possible without affecting the working routines. However, the unexpected reduction in clavicular trapezius rest during a

  11. A High Intensity Linac for the National Spallation Neutron Source

    Science.gov (United States)

    Jason, A.; Bhatia, T.; Billen, J.; Schrage, D.; Kurennoy, S.; Krawczyk, F.; Lynch, M.; Nath, S.; Shafer, R.; Takeda, H.; Tallerico, P.; Wangler, T.; Wood, R.; Young, L.; Grand, P.; McKenzie-Wilson, R.

    1997-05-01

    The National Spallation Neutron Source to be constructed at Oak Ridge National Laboratory, requires a linac capable of delivering up to 5 MW of beam power to an accumulator ring with a nominal 6.2% duty factor and an energy of 1 GeV. Los Alamos, responsible for the linac design, has developed an appropriate room-temperature linac that consists of a drift-tube section from 2.5 to 20 MeV, a coupled-cavity drift-tube section to 100 MeV, and a coupled-cavity section to 1 GeV. The initial scenario requires an average 1.1-mA beam current with a corresponding 28 mA peak current and a 1.2-Mhz chopped time structure corresponding to the ring period. Upgrade to a 4.4 mA average current requires funneling with a peak current of 112 mA in the high-energy sections. Further parameters are presented along with beam dynamics and structure choices and mechanical and rf engineering considerations.

  12. Diffraction Gratings for High-Intensity Laser Applications

    Energy Technology Data Exchange (ETDEWEB)

    Britten, J

    2008-01-23

    The scattering of light into wavelength-dependent discrete directions (orders) by a device exhibiting a periodic modulation of a physical attribute on a spatial scale similar to the wavelength of light has been the subject of study for over 200 years. Such a device is called a diffraction grating. Practical applications of diffraction gratings, mainly for spectroscopy, have been around for over 100 years. The importance of diffraction gratings in spectroscopy for the measurement of myriad properties of matter can hardly be overestimated. Since the advent of coherent light sources (lasers) in the 1960's, applications of diffraction gratings in spectroscopy have further exploded. Lasers have opened a vast application space for gratings, and apace, gratings have enabled entirely new classes of laser systems. Excellent reviews of the history, fundamental properties, applications and manufacturing techniques of diffraction gratings up to the time of their publication can be found in the books by Hutley (1) and more recently Loewen and Popov (2). The limited scope of this chapter can hardly do justice to such a comprehensive subject, so the focus here will be narrowly limited to characteristics required for gratings suitable for high-power laser applications, and methods to fabricate them. A particular area of emphasis will be on maximally-efficient large-aperture gratings for short-pulse laser generation.

  13. High Performance Data Transfer for Distributed Data Intensive Sciences

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Chin [Zettar Inc., Mountain View, CA (United States); Cottrell, R ' Les' A. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Hanushevsky, Andrew B. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Kroeger, Wilko [SLAC National Accelerator Lab., Menlo Park, CA (United States); Yang, Wei [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2017-03-06

    We report on the development of ZX software providing high performance data transfer and encryption. The design scales in: computation power, network interfaces, and IOPS while carefully balancing the available resources. Two U.S. patent-pending algorithms help tackle data sets containing lots of small files and very large files, and provide insensitivity to network latency. It has a cluster-oriented architecture, using peer-to-peer technologies to ease deployment, operation, usage, and resource discovery. Its unique optimizations enable effective use of flash memory. Using a pair of existing data transfer nodes at SLAC and NERSC, we compared its performance to that of bbcp and GridFTP and determined that they were comparable. With a proof of concept created using two four-node clusters with multiple distributed multi-core CPUs, network interfaces and flash memory, we achieved 155Gbps memory-to-memory over a 2x100Gbps link aggregated channel and 70Gbps file-to-file with encryption over a 5000 mile 100Gbps link.

  14. A 3 GHz photoelectron gun for high beam intensity

    CERN Document Server

    Bossart, Rudolf; Dehler, M; Godot, J C

    1996-01-01

    For the Compact Linear Collider Test Facility (CTF) at CERN a new rf gun with a laser driven photocathode is under construction. The new rf gun will replace the present 11/2 cell gun and will consist of 21/2 cells accelerating the beam to a momentum of 7.0 MeV/c with an electric field strength of 100 MV/m. The strong space-charge forces at low beam energy caused by the high charge density of the electron bunches are contained by radial and longitudinal rf focusing in the gun. The rf gun under construction has been optimized by MAFIA beam simulations for an injector assembly comprising a second accelerating rf structure and an intermediate solenoid magnet correcting the beam divergence of the 21/2 cell gun. The beam loading of the rf gun, by a train of 48 bunches with 21 nC charge each, causes a strong energy decay accompanied by an increase of the flight time for the bunches with lower energy. These effects can be corrected by slightly shifting the acceleration frequency of the gun. The experimental results...

  15. Bremsstrahlung production with high-intensity laser matter interactions and applications

    NARCIS (Netherlands)

    Galy, J.; Maucec, M.; Hamilton, D. J.; Edwards, R.; Magill, J.

    2007-01-01

    In the last decade an evolution of experimental relativistic laser-plasma physics has led to highly sophisticated lasers, which are now able to generate ultra short pulses and can be focused to intensities in excess of 10(21) W cm(-2), with more than 500 J on target. In the intense electric field of

  16. Bremsstrahlung production with high-intensity laser matter interactions and applications

    NARCIS (Netherlands)

    Galy, J.; Maucec, M.; Hamilton, D. J.; Edwards, R.; Magill, J.

    2007-01-01

    In the last decade an evolution of experimental relativistic laser-plasma physics has led to highly sophisticated lasers, which are now able to generate ultra short pulses and can be focused to intensities in excess of 10(21) W cm(-2), with more than 500 J on target. In the intense electric field of

  17. Scoring system for the selection of high-risk patients in the intensive care unit

    NARCIS (Netherlands)

    Iapichino, G; Mistraletti, G; Corbella, D; Bassi, G; Borotto, E; Miranda, DR; Morabito, A

    2006-01-01

    Objective. Patients admitted to the intensive care unit greatly differ in severity and intensity of care. We devised a system for selecting high-risk patients that reduces bias by excluding low-risk patients and patients with an early death irrespective of the treatment. Design: A posteriori analysi

  18. Is moderate intensity exercise training combined with high intensity interval training more effective at improving cardiorespiratory fitness than moderate intensity exercise training alone?

    Science.gov (United States)

    Roxburgh, Brendon H; Nolan, Paul B; Weatherwax, Ryan M; Dalleck, Lance C

    2014-09-01

    The purpose of this study was to compare the effectiveness of either continuous moderate intensity exercise training (CMIET) alone vs. CMIET combined with a single weekly bout of high intensity interval training (HIIT) on cardiorespiratory fitness. Twenty nine sedentary participants (36.3 ± 6.9 yrs) at moderate risk of cardiovascular disease were recruited for 12 weeks of exercise training on a treadmill and cycle ergometer. Participants were randomised into three groups: CMIET + HIIT (n = 7; 8-12 x 60 sec at 100% VO2max, 150 sec active recovery), CMIET (n = 6; 30 min at 45-60% oxygen consumption reserve (VO2R)) and a sedentary control group (n = 7). Participants in the CMIET + HIIT group performed a single weekly bout of HIIT and four weekly sessions of CMIET, whilst the CMIET group performed five weekly CMIET sessions. Probabilistic magnitude-based inferences were determined to assess the likelihood that the true value of the effect represents substantial change. Relative VO2max increased by 10.1% (benefit possible relative to control) in in the CMIET + HIIT group (32.7 ± 9.2 to 36.0 ± 11.5 mL·kg(-1)·min(-1)) and 3.9% (benefit possible relative to control) in the CMIET group (33.2 ± 4.0 to 34.5 ± 6.1 mL·kg(-1)·min(-1)), whilst there was a 5.7% decrease in the control group (30.0 ± 4.6 to 28.3 ± 6.5 mL·kg(-1)·min(-1)). It was 'unclear' if a clinically significant difference existed between the effect of CMIET + HIIT and CMIET on the change in VO2max. Both exercising groups showed clinically meaningful improvements in VO2max. Nevertheless, it remains 'unclear' whether one type of exercise training regimen elicits a superior improvement in cardiorespiratory fitness relative to its counterpart. Key PointsBoth continuous moderate intensity exercise training (CMIET) alone and CMIET combined with a single weekly bout of high intensity interval training (CMIET + HIIT) elicit 'possibly beneficial' clinically meaningful improvements in cardiorespiratory

  19. Remote Sensing Tertiary Education Meets High Intensity Interval Training

    Science.gov (United States)

    Joyce, K. E.; White, B.

    2015-04-01

    Enduring a traditional lecture is the tertiary education equivalent of a long, slow, jog. There are certainly some educational benefits if the student is able to maintain concentration, but they are just as likely to get caught napping and fall off the back end of the treadmill. Alternatively, a pre-choreographed interactive workshop style class requires students to continually engage with the materials. Appropriately timed breaks or intervals allow students to recover briefly before being increasingly challenged throughout the class. Using an introductory remote sensing class at Charles Darwin University, this case study presents a transition from the traditional stand and deliver style lecture to an active student-led learning experience. The class is taught at undergraduate and postgraduate levels, with both on-campus as well as online distance learning students. Based on the concept that active engagement in learning materials promotes 'stickiness' of subject matter, the remote sensing class was re-designed to encourage an active style of learning. Critically, class content was reviewed to identify the key learning outcomes for the students. This resulted in a necessary sacrifice of topic range for depth of understanding. Graduates of the class reported high levels of enthusiasm for the materials, and the style in which the class was taught. This paper details a number of techniques that were used to engage students in active and problem based learning throughout the semester. It suggests a number of freely available tools that academics in remote sensing and related fields can readily incorporate into their teaching portfolios. Moreover, it shows how simple it can be to provide a far more enjoyable and effective learning experience for students than the one dimensional lecture.

  20. Fast rate fracture of aluminum using high intensity lasers

    Science.gov (United States)

    Dalton, Douglas Allen

    Laser induced shock experiments were performed to study the dynamics of various solid state material processes, including shock-induced melt, fast rate fracture, and elastic to plastic response. Fast rate fracture and dynamic yielding are greatly influenced by microstructural features such as grain boundaries, impurity particles and alloying atoms. Fast fracture experiments using lasers are aimed at studying how material microstructure affects the tensile fracture characteristics at strain rates above 106 s-1. We used the Z-Beamlet Laser at Sandia National Laboratories to drive shocks via ablation and we measured the maximum tensile stress of aluminum targets with various microstructures. Using a velocity interferometer and sample recovery, we are able to measure the maximum tensile stress and determine the source of fracture initiation in these targets. We have explored the role that grain size, impurity particles and alloying in aluminum play in dynamic yielding and spall fracture at tensile strain rates of ˜3x106 s-1. Preliminary results and analysis indicated that material grain size plays a vital role in the fracture morphology and spall strength results. In a study with single crystal aluminum specimens, velocity measurements and fracture analysis revealed that a smaller amplitude tensile stress was initiated by impurity particles; however, these particles served no purpose in dynamic yielding. An aluminum-magnesium alloy with various grain sizes presented the lowest spall strength, but the greatest dynamic yield strength. Fracture mode in this alloy was initiated by both grain boundaries and impurity particles. With respect to dynamic yielding, alloying elements such as magnesium serve to decrease the onset of plastic response. The fracture stress and yield stress showed no evidence of grain size dependence. Hydrodynamic simulations with material strength models are used to compare with our experiments. In order to study the strain rate dependence of spall

  1. The high intensity solar cell: Key to low cost photovoltaic power

    Science.gov (United States)

    Sater, B. L.; Goradia, C.

    1975-01-01

    The design considerations and performance characteristics of the 'high intensity' (HI) solar cell are presented. A high intensity solar system was analyzed to determine its cost effectiveness and to assess the benefits of further improving HI cell efficiency. It is shown that residential sized systems can be produced at less than $1000/kW peak electric power. Due to their superior high intensity performance characteristics compared to the conventional and VMJ cells, HI cells and light concentrators may be the key to low cost photovoltaic power.

  2. Risk profiling of hookworm infection and intensity in southern Lao People's Democratic Republic using Bayesian models.

    Science.gov (United States)

    Forrer, Armelle; Vounatsou, Penelope; Sayasone, Somphou; Vonghachack, Youthanavanh; Bouakhasith, Dalouny; Utzinger, Jürg; Akkhavong, Kongsap; Odermatt, Peter

    2015-03-01

    Among the common soil-transmitted helminth infections, hookworm causes the highest burden. Previous research in the southern part of Lao People's Democratic Republic (Lao PDR) revealed high prevalence rates of hookworm infection. The purpose of this study was to predict the spatial distribution of hookworm infection and intensity, and to investigate risk factors in the Champasack province, southern Lao PDR. A cross-sectional parasitological and questionnaire survey was conducted in 51 villages. Data on demography, socioeconomic status, water, sanitation, and behavior were combined with remotely sensed environmental data. Bayesian mixed effects logistic and negative binomial models were utilized to investigate risk factors and spatial distribution of hookworm infection and intensity, and to make predictions for non-surveyed locations. A total of 3,371 individuals were examined with duplicate Kato-Katz thick smears and revealed a hookworm prevalence of 48.8%. Most infections (91.7%) were of light intensity (1-1,999 eggs/g of stool). Lower hookworm infection levels were associated with higher socioeconomic status. The lowest infection levels were found in preschool-aged children. Overall, females were at lower risk of infection, but women aged 50 years and above harbored the heaviest hookworm infection intensities. Hookworm was widespread in Champasack province with little evidence for spatial clustering. Infection risk was somewhat lower in the lowlands, mostly along the western bank of the Mekong River, while infection intensity was homogeneous across the Champasack province. Hookworm transmission seems to occur within, rather than between villages in Champasack province. We present spatial risk maps of hookworm infection and intensity, which suggest that control efforts should be intensified in the Champasack province, particularly in mountainous areas.

  3. Front versus rear side light-ion acceleration from high-intensity laser-solid interactions

    Science.gov (United States)

    Willingale, L.; Petrov, G. M.; Maksimchuk, A.; Davis, J.; Freeman, R. R.; Matsuoka, T.; Murphy, C. D.; Ovchinnikov, V. M.; Van Woerkom, L.; Krushelnick, K.

    2011-01-01

    The source of ions accelerated from high-intensity laser interactions with thin foil targets is investigated by coating a deuterated plastic layer either on the front, rear or both surfaces of thin foil targets. The originating surface of the deuterons is therefore known and this method is used to assess the relative source contributions and maximum energies using a Thomson parabola spectrometer to obtain high-resolution light-ion spectra. Under these experimental conditions, laser intensity of (0.5-2.5) × 1019 W cm-2, pulse duration of 400 fs and target thickness of 6-13 µm, deuterons originating from the front surface can gain comparable maximum energies as those from the rear surface and spectra from either side can deviate from Maxwellian. Two-dimensional particle-in-cell simulations model the acceleration and show that any presence of a proton rich contamination layer over the surface is detrimental to the deuteron acceleration from the rear surface, whereas it is likely to be less influential on the front side acceleration mechanism.

  4. High-intensity interval training prevents oxidant-mediated diaphragm muscle weakness in hypertensive mice.

    Science.gov (United States)

    Bowen, T Scott; Eisenkolb, Sophia; Drobner, Juliane; Fischer, Tina; Werner, Sarah; Linke, Axel; Mangner, Norman; Schuler, Gerhard; Adams, Volker

    2017-01-01

    Hypertension is a key risk factor for heart failure, with the latter characterized by diaphragm muscle weakness that is mediated in part by increased oxidative stress. In the present study, we used a deoxycorticosterone acetate (DOCA)-salt mouse model to determine whether hypertension could independently induce diaphragm dysfunction and further investigated the effects of high-intensity interval training (HIIT). Sham-treated (n = 11), DOCA-salt-treated (n = 11), and DOCA-salt+HIIT-treated (n = 15) mice were studied over 4 wk. Diaphragm contractile function, protein expression, enzyme activity, and fiber cross-sectional area and type were subsequently determined. Elevated blood pressure confirmed hypertension in DOCA-salt mice independent of HIIT (P HIIT. Myosin heavy chain (MyHC) protein expression tended to decrease (∼30%; P = 0.06) in DOCA-salt vs. sham- and DOCA-salt+HIIT mice, whereas oxidative stress increased (P HIIT further prevented direct oxidant-mediated diaphragm contractile dysfunction (P HIIT.-Bowen, T. S., Eisenkolb, S., Drobner, J., Fischer, T., Werner, S., Linke, A., Mangner, N., Schuler, G., Adams, V. High-intensity interval training prevents oxidant-mediated diaphragm muscle weakness in hypertensive mice.

  5. Time Integrated Soft X-ray Imaging in High Intensity Laser Experiments (thesis)

    Energy Technology Data Exchange (ETDEWEB)

    Stafford, David [Univ. of California, Davis, CA (United States)

    2009-01-01

    2009 marks a significant achievement and the dawn of a new era in high intensity laser research with the final commissioning of all 192 beams at the National Ignition Facility (NIF). NIF is a department of energy (DOE) funded project more than 10 years in the making located at the Lawrence Livermore National Laboratory (LLNL). The following research was done as one of many preliminary experiments done to prepare for these historic events. The primary focus of the experimental campaign this paper addresses is to test and develop a thermal x-radiation source using a short pulse laser. This data is hoped to provide information about the thermal transport mechanisms important in the development of prediction models in High Energy Density (HED) science. One of several diagnostics fielded was a soft x-ray imager (SXRI) which is detailed in this paper. The SXRI will be used to measure the relative size of the heated region and also the relative level of specific x-ray emissions among several shot and target configurations. The laser system used was the Titan laser located in the Jupiter Laser Facility (JLF) at Lawrence Livermore National Laboratory (LLNL). Titan uses the JLF Janus Nd:glass laser west frontend system with a Optical Parametric Chirped Pulse Amplification (OPCPA) in place of the nanosecond oscillator. The system is capable of producing laser intensities of over a petawatt with several tens of joules delivered in the beam.

  6. Improved highly accurate localized motion imaging for monitoring high-intensity focused ultrasound therapy

    Science.gov (United States)

    Qu, Xiaolei; Azuma, Takashi; Sugiyama, Ryusuke; Kanazawa, Kengo; Seki, Mika; Sasaki, Akira; Takeuchi, Hideki; Fujiwara, Keisuke; Itani, Kazunori; Tamano, Satoshi; Takagi, Shu; Sakuma, Ichiro; Matsumoto, Yoichiro

    2016-07-01

    Visualizing an area subjected to high-intensity focused ultrasound (HIFU) therapy is necessary for controlling the amount of HIFU exposure. One of the promising monitoring methods is localized motion imaging (LMI), which estimates coagulation length by detecting the change in stiffness. In this study, we improved the accuracy of our previous LMI by dynamic cross-correlation window (DCCW) and maximum vibration amount (MVA) methods. The DCCW method was used to increase the accuracy of estimating vibration amplitude, and the MVA method was employed to increase signal-noise ratio of the decrease ratio at the coagulated area. The qualitative comparison of results indicated that the two proposed methods could suppress the effect of noise. Regarding the results of the quantitative comparison, coagulation length was estimated with higher accuracy by the improved LMI method, and the root-mean-square error (RMSE) was reduced from 2.51 to 1.69 mm.

  7. Mapping and modelling of changes in agricultural intensity in Europe

    NARCIS (Netherlands)

    Temme, A.J.A.M.; Verburg, P.H.

    2011-01-01

    Spatial maps of agricultural intensity are needed for analyses of environmental issues, including biodiversity changes. We present a method to produce such maps for Europe. While most studies beyond farm level focus on land cover change only, this paper focuses on spatial variation in land use

  8. High-Intensity Training Improves Global and Segmental Strains in Severe Congestive Heart Failure.

    Science.gov (United States)

    Blumberg, Yair; Ertracht, Offir; Gershon, Itai; Bachner-Hinenzon, Noa; Reuveni, Tali; Atar, Shaul

    2017-05-01

    High-intensity training (HIT) is superior to moderate aerobic training (MAT) for improving quality of life in congestive heart failure (CHF) patients. Speckle-tracking echocardiography (STE) has recently been suggested for estimation of left ventricle global and regional function. We evaluated the utility of STE for characterizing differences in cardiac function following MAT or HIT in a CHF rat model. After baseline physiologic assessment, CHF was induced by means of coronary artery ligation in Sprague-Dawley rats. Repeated measurements confirmed the presence of CHF (ejection fraction 52 ± 10%, global circumferential strain (GCS) 10.5 ± 4, and maximal oxygen uptake (V˙O2max) 71 ± 11 mL⋅min(-1)⋅kg(-1); P training protocols: sedentary (SED), MAT, or HIT. After the training period, rats underwent the same measurements and were killed. Training intensity improved V˙O2max (73 ± 13 mL⋅min(-1)⋅kg(-1) in MAT [P  .05 vs baseline]). In addition, strains of specific segments adjacent to the infarct zone regained basal values (P > .05 vs baseline), whereas global cardiac functional parameters as assessed with the use of 2-dimensional echocardiography did not improve. High-intensity exercise training improved function in myocardial segments remote from the scar, which resulted in compensatory cardiac remodeling. This effect is prominent, yet it could be detected only with the use of STE. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Meeting standards of high-quality intensive care unit palliative care: clinical performance and predictors.

    Science.gov (United States)

    Penrod, Joan D; Pronovost, Peter J; Livote, Elayne E; Puntillo, Kathleen A; Walker, Amy S; Wallenstein, Sylvan; Mercado, Alice F; Swoboda, Sandra M; Ilaoa, Debra; Thompson, David A; Nelson, Judith E

    2012-04-01

    High-quality care for intensive care unit patients and families includes palliative care. To promote performance improvement, the Agency for Healthcare Research and Quality's National Quality Measures Clearinghouse identified nine evidence-based processes of intensive care unit palliative care (Care and Communication Bundle) that are measured through review of medical record documentation. We conducted this study to examine how frequently the Care and Communication Bundle processes were performed in diverse intensive care units and to understand patient factors that are associated with such performance. Prospective, multisite, observational study of performance of key intensive care unit palliative care processes. A surgical intensive care unit and a medical intensive care unit in two different large academic health centers and a medical-surgical intensive care unit in a medium-sized community hospital. Consecutive adult patients with length of intensive care unit stay ≥5 days. None. Between November 2007 and December 2009, we measured performance by specified day after intensive care unit admission on nine care process measures: Identify medical decision-maker, advance directive and resuscitation preference, distribute family information leaflet, assess and manage pain, offer social work and spiritual support, and conduct interdisciplinary family meeting. Multivariable regression analysis was used to determine predictors of performance of five care processes. We enrolled 518 (94.9%) patients and 336 (83.6%) family members. Performances on pain assessment and management measures were high. In contrast, interdisciplinary family meetings were documented for <20% of patients by intensive care unit day 5. Performance on other measures ranged from 8% to 43%, with substantial variation across and within sites. Chronic comorbidity burden and site were the most consistent predictors of care process performance. Across three intensive care units in this study, performance

  10. Medication errors in the intensive care unit: literature review using the SEIPS model.

    Science.gov (United States)

    Frith, Karen H

    2013-01-01

    Medication errors in intensive care units put patients at risk for injury or death every day. Safety requires an organized and systematic approach to improving the tasks, technology, environment, and organizational culture associated with medication systems. The Systems Engineering Initiative for Patient Safety model can help leaders and health care providers understand the complicated and high-risk work associated with critical care. Using this model, the author combines a human factors approach with the well-known structure-process-outcome model of quality improvement to examine research literature. The literature review reveals that human factors, including stress, high workloads, knowledge deficits, and performance deficits, are associated with medication errors. Factors contributing to medication errors are frequent interruptions, communication problems, and poor fit of health information technology to the workflow of providers. Multifaceted medication safety interventions are needed so that human factors and system problems can be addressed simultaneously.

  11. Inverse bremsstrahlung absorption with nonlinear effects of high laser intensity and non-Maxwellian distribution.

    Science.gov (United States)

    Weng, Su-Ming; Sheng, Zheng-Ming; Zhang, Jie

    2009-11-01

    Inverse bremsstrahlung (IB) absorption and evolution of the electron distribution function (EDF) in a wide laser intensity range (10;{12}-10;{17} W/cm;{2}) have been studied systematically by a two velocity-dimension Fokker-Planck code. It is found that Langdon's IB operator overestimates the absorption rate at high laser intensity, consequently with an overdistorted non-Maxwellian EDF. According to the small anisotropy of EDF in the oscillation frame, we introduce an IB operator which is similar to Langdon's but without the low laser intensity limit. This operator is appropriate for self-consistently tackling the nonlinear effects of high laser intensity as well as non-Maxwellian EDF. Particularly, our operator is capable of treating IB absorption properly in the indirect and direct-drive inertial confinement fusion schemes with the National Ignition Facility and Laser MegaJoule laser parameters at focused laser intensity beyond 10;{15} W/cm;{2} .

  12. High-density operation of the Proto-MPEX High Intensity Plasma Source

    Science.gov (United States)

    Caughman, J. B. O.; Goulding, R. H.; Biewer, T. M.; Bigelow, T. S.; Campbell, I. H.; Caneses, J.; Diem, S. J.; Martin, E. H.; Parish, C. M.; Rapp, J.; Ray, H. B.; Shaw, G. C.; Showers, M. A.; Donovan, D.; Piotrowicz, P. A.; Martin, D. C.

    2016-10-01

    The Prototype Materials Plasma Experiment (Proto-MPEX) is a linear high-intensity RF plasma source that combines a high-density helicon plasma generator with ion and electron heating sections. It is being used to study the physics of heating over-dense plasmas in a linear configuration with the goal of delivering a plasma heat flux of 10 MW/m2 at a target. The helicon plasma is produced by coupling 13.56 MHz RF power at levels of >100 kW. A 30 kW ion cyclotron antenna has recently been installed, and microwaves at 28 GHz ( 150 kW) are coupled to the electrons in the over-dense helicon plasma via Electron Bernstein Waves (EBW). High plasma densities near the target have been produced in D ( 5 x1019/m3) , and electron temperatures range from 3 to >10 eV, depending on the source parameters. IR camera images of the target plate indicate plasma heat depositions >10 MW/m2 for some operating conditions. Details of the experimental results of the operational domain with respect to Te and ne as well as results from initial plasma material interaction tests will be presented. ORNL is managed by UT-Battelle, LLC, for the U.S. DOE under contract DE-AC-05-00OR22725.

  13. High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in the Prevention/Management of Cardiovascular Disease.

    Science.gov (United States)

    Hussain, Syed R; Macaluso, Andrea; Pearson, Stephen J

    Moderate-intensity continuous training (MICT) has long been considered the most effective exercise treatment modality for the prevention and management of cardiovascular disease (CVD), but more recently high-intensity interval training (HIIT) has been viewed as a potential alternative to MICT in accruing such benefits. HIIT was initially found to induce significant improvements in numerous physiological and health-related indices, to a similar if not superior extent to MICT. Since then, many studies have attempted to explore the potential clinical utility of HIIT, relative to MICT, with respect to treating numerous cardiovascular conditions, such as coronary artery disease, heart failure, stroke, and hypertension. Despite this, however, the efficacy of HIIT in reversing the specific symptoms and risk factors of these cardiovascular pathologies is not well understood. HIIT is often perceived as very strenuous, which could render it unsafe for those at risk of or afflicted with CVD, but these issues are also yet to be reviewed. Furthermore, the optimal HIIT protocol for each of the CVD cohorts has not been established. Thus, the purpose of this review article is to (1) evaluate the efficacy of HIIT relative to MICT in the prevention and management of cardiovascular conditions, and (2) explore any potential safety issues surrounding the suitability and/or tolerability of HIIT for patients with CVD, and the potential optimal prescriptive variables of HIIT for application in the clinical environment.

  14. Intensive lifestyle intervention including high-intensity interval training program improves insulin resistance and fasting plasma glucose in obese patients.

    Science.gov (United States)

    Marquis-Gravel, Guillaume; Hayami, Douglas; Juneau, Martin; Nigam, Anil; Guilbeault, Valérie; Latour, Élise; Gayda, Mathieu

    2015-01-01

    To analyze the effects of a long-term intensive lifestyle intervention including high-intensity interval training (HIIT) and Mediterranean diet (MedD) counseling on glycemic control parameters, insulin resistance and β-cell function in obese subjects. The glycemic control parameters (fasting plasma glucose, glycated hemoglobin), insulin resistance, and β-cell function of 72 obese subjects (54 women; mean age = 53 ± 9 years) were assessed at baseline and upon completion of a 9-month intensive lifestyle intervention program conducted at the cardiovascular prevention and rehabilitation center of the Montreal Heart Institute, from 2009 to 2012. The program included 2-3 weekly supervised exercise training sessions (HIIT and resistance exercise), combined to MedD counseling. Fasting plasma glucose (FPG) (mmol/L) (before: 5.5 ± 0.9; after: 5.2 ± 0.6; P fasting insulin (pmol/L) (before: 98 ± 57; after: 82 ± 43; P = 0.003), and insulin resistance, as assessed by the HOMA-IR score (before: 3.6 ± 2.5; after: 2.8 ± 1.6; P = 0.0008) significantly improved, but not HbA1c (%) (before: 5.72 ± 0.55; after: 5.69 ± 0.39; P = 0.448), nor β-cell function (HOMA-β, %) (before: 149 ± 78; after: 144 ± 75; P = 0.58). Following a 9-month intensive lifestyle intervention combining HIIT and MedD counseling, obese subjects experienced significant improvements of FPG and insulin resistance. This is the first study to expose the effects of a long-term program combining HIIT and MedD on glycemic control parameters among obese subjects.

  15. A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread

    Directory of Open Access Journals (Sweden)

    Smieszek Timo

    2009-11-01

    Full Text Available Abstract Background Mathematical models and simulations of disease spread often assume a constant per-contact transmission probability. This assumption ignores the heterogeneity in transmission probabilities, e.g. due to the varying intensity and duration of potentially contagious contacts. Ignoring such heterogeneities might lead to erroneous conclusions from simulation results. In this paper, we show how a mechanistic model of disease transmission differs from this commonly used assumption of a constant per-contact transmission probability. Methods We present an exposure-based, mechanistic model of disease transmission that reflects heterogeneities in contact duration and intensity. Based on empirical contact data, we calculate the expected number of secondary cases induced by an infector (i for the mechanistic model and (ii under the classical assumption of a constant per-contact transmission probability. The results of both approaches are compared for different basic reproduction numbers R0. Results The outcomes of the mechanistic model differ significantly from those of the assumption of a constant per-contact transmission probability. In particular, cases with many different contacts have much lower expected numbers of secondary cases when using the mechanistic model instead of the common assumption. This is due to the fact that the proportion of long, intensive contacts decreases in the contact dataset with an increasing total number of contacts. Conclusion The importance of highly connected individuals, so-called super-spreaders, for disease spread seems to be overestimated when a constant per-contact transmission probability is assumed. This holds particularly for diseases with low basic reproduction numbers. Simulations of disease spread should weight contacts by duration and intensity.

  16. Endurance capacity and neuromuscular fatigue following high- vs moderate-intensity endurance training: A randomized trial.

    Science.gov (United States)

    O'Leary, T J; Collett, J; Howells, K; Morris, M G

    2017-02-16

    High-intensity exercise induces significant central and peripheral fatigue; however, the effect of endurance training on these mechanisms of fatigue is poorly understood. We compared the effect of cycling endurance training of disparate intensities on high-intensity exercise endurance capacity and the associated limiting central and peripheral fatigue mechanisms. Twenty adults were randomly assigned to 6 weeks of either high-intensity interval training (HIIT, 6-8×5 minutes at halfway between lactate threshold and maximal oxygen uptake [50%Δ]) or volume-matched moderate-intensity continuous training (CONT, ~60-80 minutes at 90% lactate threshold). Two time to exhaustion (TTE) trials at 50%Δ were completed pre- and post-training to assess endurance capacity; the two post-training trials were completed at the pretraining 50%Δ (same absolute intensity) and the "new" post-training 50%Δ (same relative intensity). Pre- and post-exercise responses to femoral nerve and motor cortex stimulation were examined to determine peripheral and central fatigue, respectively. HIIT resulted in greater increases in TTE at the same absolute and relative intensities as pre-training (148% and 43%, respectively) compared with CONT (38% and -4%, respectively) (P≤.019). Compared with pre-training, HIIT increased the level of potentiated quadriceps twitch reduction (-34% vs -43%, respectively, P=.023) and attenuated the level of voluntary activation reduction (-7% vs -3%, respectively, P=.047) following the TTE trial at the same relative intensity. There were no other training effects on neuromuscular fatigue development. This suggests that central fatigue resistance contributes to enhanced high-intensity exercise endurance capacity after HIIT by allowing greater performance to be extruded from the muscle. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. High-intensity focused ultrasound treatment of abnormal vaginal bleeding secondary to uterine myoma.

    Science.gov (United States)

    Lim, Jung Hyun; Chung, Dong Jin; Lim, Young Tec; Cho, Sae Hyun; Lee, Jae Mun; Hahn, Seong-Tae

    2011-03-01

    We describe the use of high-intensity focused ultrasound for acute vaginal bleeding secondary to uterine myoma in 2 young female patients. Both patients had episodes of abnormal vaginal bleeding with severe dysmenorrhea that was not efficiently controlled by medical treatment. After high-intensity focused ultrasound ablation, both vaginal bleeding control and symptom relief were achieved without postinterventional complications. The patients remained free of symptoms during 2 months of follow-up and regained normal menstruation after high-intensity focused ultrasound therapy. High-intensity focused ultrasound treatment is one of the least invasive options for dysfunctional vaginal bleeding and may be an effective and safe alternative to other procedures in women of reproductive age with abnormal vaginal bleeding secondary to uterine myoma.

  18. High speed traveling wave electrooptic intensity modulator with a doped PIN semiconductor junction

    Energy Technology Data Exchange (ETDEWEB)

    Vawter, G.A.; Hietala, V.M.; Wendt, J.R.; Fuchs, B.A.; Hafich, M.; Housel, M.; Armendariz, M.; Sullivan, C.T.

    1996-02-01

    A high-electrooptic-efficiency Mach-Zehnder intensity modulator is demonstrated with a bandwidth exceeding 40 GHZ. The 1 mm-long modulator has a switching voltage comparable to undoped semiconductor designs of much greater length.

  19. Effect of low-intensity extremely high frequency radiation on reproductive function in wistar rats.

    Science.gov (United States)

    Subbotina, T I; Tereshkina, O V; Khadartsev, A A; Yashin, A A

    2006-08-01

    The exposure to low-intensity extremely high frequency electromagnetic radiation during spermatogenesis was accompanied by pathological changes, which resulted in degeneration and polymorphism of spermatozoa. The number of newborn rats increased in the progeny of irradiated animals.

  20. Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

    Directory of Open Access Journals (Sweden)

    Shin Yoshizawa

    2017-03-01

    Full Text Available A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this paper, a method named “trigger HIFU exposure” which employs cavitation microbubbles is introduced and its results are reviewed. A trigger HIFU sequence consists of high-intensity short pulses followed by moderate-intensity long bursts. Cavitation bubbles induced in a multiple focal regions by rapidly scanning the focus of high-intensity pulses enhanced the temperature increase significantly and produced a large coagulation region with high efficiency.

  1. High-Intensity Intermittent Exercise: Effect on Young People's Cardiometabolic Health and Cognition.

    Science.gov (United States)

    Cooper, Simon B; Dring, Karah J; Nevill, Mary E

    2016-01-01

    With only a quarter of young people currently meeting physical activity guidelines, two key areas of concern are the effects of exercise on cardiometabolic health and cognition. Despite the fact that physical activity in young people is typically high intensity and intermittent in nature, much of the literature examines traditional endurance-type exercise. This review provides an update on the effects of high-intensity intermittent exercise on young people's cardiometabolic health and cognition. High-intensity intermittent exercise has acute beneficial effects on endothelial function and postprandial lipemia and chronic positive effects on weight management. In addition, there is emerging evidence regarding chronic benefits on the blood lipid profile, blood pressure, and proinflammatory and anti-inflammatory cytokines. Furthermore, emerging evidence suggests beneficial acute and chronic effects of high-intensity intermittent exercise on cognition. However, further research is required in both cardiometabolic health and cognition, particularly regarding the impact of school-based interventions in adolescents.

  2. Influence of mature men way of life on highly intensive physical activity

    Directory of Open Access Journals (Sweden)

    O.B. Pryshva

    2017-04-01

    Full Text Available Highly intensive physical activity is the most effective for men’s health protection. In modern life conditions its level is insufficient. It requires organism’s appropriate physical activity, which is determined by way of life. Especially important it is before trainings. Purpose: to study special aspects of different intensity’s physical activity; of eating special food and sleeping regime of mature men before their highly intensive physical trainings. Material: in experiment men (n=26, age - 35-53years, who practice healthy life style and independent physical activity of high intensity, participated. We used bio-register Basis B1. Every day we registered: Peak - physical activity of different intensity; duration and quality of sleep; relative weight of consumed food. Besides, we calculated body mass index and physical condition. The study was conducted during 30 days in winter period. The following results were compared: indicators before not planned physical activity and average-monthly indicators. Results: Before arbitrary physical functioning we found in men: confident weakening of average intensity (by 9-11% and low intensity (by 10% physical activity; confident increase of consumed food’s relative weight (by 6.82%, vegetarian food (by 10.64% and raw food (by 7.61%; confident reduction of animal origin food (by 8.7%. No changes were found in duration and quality of sleep before highly intensive physical functioning. Conclusions: specific features of mature men’s way of life before their not planned highly intensive physical functioning are as follows: reduction of general physical activity; increase of consumed food. These factors facilitate energy accumulation in organism for its realization in highly intensive physical functioning the next day.

  3. Design and implementation of capacitive micromachined ultrasonic transducers for high intensity focused ultrasound

    OpenAIRE

    Yamaner, Yalçın Feysel; Yamaner, Yalcin Feysel

    2011-01-01

    High intensity focused ultrasound (HIFU) is a medical procedure for noninvasive treatment of cancers. High intensity focused ultrasound is used to heat and destroy the diseased tissue. Piezoelectricity has been the core mechanism for generation of ultrasound waves in the treatment. Focusing can be done by using spherically curved transducers or using a lens or electronically steering sound waves by using phased arrays. Current research in HIFU technology targets the development of MR-guided m...

  4. Design concept of radiation control system for the high intensity proton accelerator facility

    CERN Document Server

    Miyamoto, Y; Harada, Y; Ikeno, K

    2002-01-01

    Description is given for the characteristic radiation environment for the High Intensity Proton Accelerator Facility and the design concept of the radiation control system of it. The facility is a large scale accelerator complex consisting of high energy proton accelerators carrying the highest beam intensity in the world and the related experimental facilities and therefore provides various issues relevant to the radiation environment. The present report describes the specifications for the radiation control system for the facility, determined in consideration of these characteristics.

  5. No Effect of Exercise Intensity on Appetite in Highly-Trained Endurance Women

    OpenAIRE

    Howe, Stephanie M; Taryn M. Hand; D. Enette Larson-Meyer; Kathleen J. Austin; Alexander, Brenda M.; Melinda M. Manore

    2016-01-01

    In endurance-trained men, an acute bout of exercise is shown to suppress post-exercise appetite, yet limited research has examined this response in women. The purpose of this study was to investigate the effect of exercise intensity on appetite and gut hormone responses in endurance-trained women. Highly-trained women (n = 15, 18–40 years, 58.4 ± 6.4 kg, VO2MAX = 55.2 ± 4.3 mL/kg/min) completed isocaloric bouts (500 kcals or 2093 kJ) of moderate-intensity (MIE, 60% VO2MAX) and high-intensity ...

  6. Mediterranean diet, moderate-to-high intensity training, and health-related quality of life in adults with metabolic syndrome.

    Science.gov (United States)

    Landaeta-Díaz, L; Fernández, J M; Da Silva-Grigoletto, M; Rosado-Alvarez, D; Gómez-Garduño, A; Gómez-Delgado, F; López-Miranda, J; Pérez-Jiménez, F; Fuentes-Jiménez, F

    2013-08-01

    Much recent research has focused on the benefits of the Mediterranean diet on risk factors of metabolic syndrome (MetS). In addition numerous investigations have also demonstrated that moderate and high-intensity endurance training may induce greater beneficial adaptations in body composition and cardiometabolic risk than low-intensity endurance training. How a model of Mediterranean diet with and without moderate-to-high intensity training influences health-related quality of life (HRQoL) and physical fitness in MetS patients is unknown. A total of 45 sedentary MetS males and females (50⊟66 years) were randomly divided into two groups: (a) hypocaloric, normoproteic Mediterranean diet (MeD); and (b) the same diet plus periodized moderate-to-high intensity training (MeDE) for 12 weeks. HRQoL (EuroQol and SF-36 questionnaires), fitness, response to submaximal exercise, and risk factors of MetS were determined before and after treatment. MeD improved some physical and mental domains of HRQoL (physical function, vitality, general physical health, emotional role, and self-perception of health) and resulted in weight loss and improvement of MetS risk factors (intra-group p high intensity training may lead to greater improvement in HRQoL through a greater effect on physical and functional fitness, bodyweight, and risk factors than diet alone.

  7. Associations of Low- and High-Intensity Light Activity with Cardiometabolic Biomarkers.

    Science.gov (United States)

    Howard, Bethany; Winkler, Elisabeth A H; Sethi, Parneet; Carson, Valerie; Ridgers, Nicola D; Salmon, J O; Healy, Genevieve N; Owen, Neville; Dunstan, David W

    2015-10-01

    Light-intensity physical activity (LIPA) accounts for much of adults' waking hours (≈40%) and substantially contributes to overall daily energy expenditure. Encompassing activity behaviors of low intensity (standing with little movement) to those of higher intensity (slow walking), LIPA is ubiquitous, yet little is known about how associations with health may vary depending on its intensity. We examined the associations of objectively assessed LIPA (categorized as either low LIPA [LLPA] or high LIPA [HLPA]) and moderate- to vigorous-intensity activity with cardiometabolic risk biomarkers. Cardiometabolic biomarkers were measured in 4614 US adults (47 ± 17 yr) who participated in the 2003-2004 and 2005-2006 National Health and Nutrition Examination Survey cycles. Multiple linear regression analyses examined the associations of three accelerometer-derived physical activity (SD increment per day) intensity categories (LLPA, 100-761 counts per minute; HLPA, 762-1951 counts per minute; moderate-intensity physical activity [MPA], 1952-5724 counts per minute; vigorous-intensity physical activity [VPA], ≥5725 counts per minute) with cardiometabolic biomarkers, adjusting for potential sociodemographic, behavioral, and medical confounders. All intensities of physical activity were beneficially associated with waist circumference, C-reactive protein, triglycerides, fasting insulin, β-cell function, and insulin sensitivity (P activity intensities showed significant associations with systolic blood pressure (LLPA), body mass index, HDL cholesterol, fasting glucose, and 2-h plasma glucose (HLPA, MPA, and VPA). Generally, effect size increased with intensity of physical activity. Overall, further adjustment for waist circumference attenuated associations with MPA and VPA to a greater extent than associations with LLPA and HLPA. The cross-sectional findings provide novel evidence for the potential benefits of increasing both LLPA and HLPA. They further reinforce the

  8. Design, construction, activation, and operation of a high intensity acoustic test chamber

    Science.gov (United States)

    Kamel, L. T.

    1986-01-01

    The design philosophy, construction, integration, and activation of the high intensity acoustic test chamber for production acceptance testing of satellites are discussed. The 32,000 cubic-foot acoustic test cell consists of a steel reinforced concrete chamber with six electropneumatic noise generators. One of the innovative features of the chamber is a unique quarter horn assembly that acoustically couples the noise generators to the chamber. Design concepts, model testing, and evaluation results are presented. Considerations such as nitrogen versus compressed air source, digital closed loop spectrum control versus manual equalizers, and microprocessor based interlock systems are included. Construction difficulties, anomalies encountered, and their resolution are also discussed. Results of the readiness testing are highlighted.

  9. Prepulse effects on the interaction of intense femtosecond laser pulses with high-Z solids

    Energy Technology Data Exchange (ETDEWEB)

    Zhidkov, Alexei; Sasaki, Akira; Utsumi, Takayuki; Fukumoto, Ichirou; Tajima, Toshiki; Saito, Fumikazu; Hironaka, Yoichiro; Nakamura, Kazutaka G.; Kondo, Ken-ichi; Yoshida, Masatake

    2000-11-01

    K{alpha} emission of high-Z solid targets irradiated by an intense, short (<100 fs) laser pulse in the 10 keV region is shown to be sensitive to the electron energy cutoff, which is strongly dependent on the density gradient of the plasma corona formed by a long prepulse. The absorption rate of short laser pulses, the hot electron distribution, and x-ray emission from a Cu slab target are studied via a hybrid model, which combines the hydrodynamics, collisional particle-in-cell, and Monte Carlo simulation techniques, and via a direct spectroscopic measurement. An absorption mechanism originating from the interaction of the laser pulse with plasma waves is found to increase the absorption rate by over 30% even for a very short, s-polarized laser pulse. Calculated and measured x-ray spectra are in good agreement, confirming the electron energy cutoff.

  10. A Lightweight, High-performance I/O Management Package for Data-intensive Computing

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jun

    2011-06-22

    Our group has been working with ANL collaborators on the topic bridging the gap between parallel file system and local file system during the course of this project period. We visited Argonne National Lab -- Dr. Robert Ross's group for one week in the past summer 2007. We looked over our current project progress and planned the activities for the incoming years 2008-09. The PI met Dr. Robert Ross several times such as HEC FSIO workshop 08, SC08 and SC10. We explored the opportunities to develop a production system by leveraging our current prototype to (SOGP+PVFS) a new PVFS version. We delivered SOGP+PVFS codes to ANL PVFS2 group in 2008.We also talked about exploring a potential project on developing new parallel programming models and runtime systems for data-intensive scalable computing (DISC). The methodology is to evolve MPI towards DISC by incorporating some functions of Google MapReduce parallel programming model. More recently, we are together exploring how to leverage existing works to perform (1) coordination/aggregation of local I/O operations prior to movement over the WAN, (2) efficient bulk data movement over the WAN, (3) latency hiding techniques for latency-intensive operations. Since 2009, we start applying Hadoop/MapReduce to some HEC applications with LANL scientists John Bent and Salman Habib. Another on-going work is to improve checkpoint performance at I/O forwarding Layer for the Road Runner super computer with James Nuetz and Gary Gridder at LANL. Two senior undergraduates from our research group did summer internships about high-performance file and storage system projects in LANL since 2008 for consecutive three years. Both of them are now pursuing Ph.D. degree in our group and will be 4th year in the PhD program in Fall 2011 and go to LANL to advance two above-mentioned works during this winter break. Since 2009, we have been collaborating with several computer scientists (Gary Grider, John bent, Parks Fields, James Nunez, Hsing

  11. High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress.

    Science.gov (United States)

    Gabriel, Brendan; Ratkevicius, Aivaras; Gray, Patrick; Frenneaux, Michael P; Gray, Stuart R

    2012-09-01

    Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and β-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (Phigh-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (Phigh-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.

  12. Intensity of the geomagnetic field in Europe for the last 3 ka: Influence of data quality on geomagnetic field modeling

    Science.gov (United States)

    Pavón-Carrasco, Francisco Javier; Gómez-Paccard, Miriam; Hervé, Gwenaël.; Osete, María. Luisa; Chauvin, Annick

    2014-06-01

    of the main challenges of paleomagnetic research is to obtain high-resolution geomagnetic field intensity reconstructions. For the last millennia, these reconstructions are mostly based on archeomagnetic data. However, the quality of the intensity data available in the databases is very variable, and the high scatter observed in the records clearly suggests that some of them might not be reliable. In this work we investigate how the geomagnetic field intensity reconstructions and, hence, our present knowledge of the geomagnetic field in the past, are affected by the quality of the data selected for modeling the Earth's magnetic field. For this purpose we rank the European archeointensity data in four quality categories following widely accepted paleomagnetic criteria based on the methodology used during the laboratory treatment of the samples and on the number of specimens retained to calculate the mean intensities. Four geomagnetic field regional models have been implemented by applying the revised spherical cap harmonic analysis to these four groups of input data. Geomagnetic field models strongly depend on the used data set. The model built using all the available data (without any preselection) appears to be the less accurate, indicating some internal inconsistencies of the data set. In addition, some features of this model are clearly dominated by the less reliable archeointensity data, suggesting that such features might not reflect real variations of the past geomagnetic field. On the contrary, the regional model built on selected high-quality intensity data shows a very consistent intensity pattern at the European scale, confirming that the main intensity changes observed in Europe in the recent history of the geomagnetic field occurred at the continental scale.

  13. EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON ENDOTHELIAL FUNCTION IN POSTMENOPAUSAL HYPERTENSIVE PATIENTS RANDOMIZED CONTROLLED TRIAL

    Directory of Open Access Journals (Sweden)

    Mona Mohamed Taha

    2016-02-01

    Full Text Available Background: Postmenopausal hypertension is the most common risk factor of cardiovascular morbidity and mortality. As the exercises training conveys benefits of the setting of secondary prevention of hypertension. High intensity interval training (HIIT emerged as a new form of physical training and presents as therapeutic alternative to patients and health care professionals. This study aimed to investigate the effect of high intensity interval training on endothelial function in postmenopausal hypertension. Methods: Forty six mildly hypertensive postmenopausal women, their ages ranged from (45-55 years old, were randomly allocated to two groups: HIIT group (group-I; n=23 performed a high intensity interval training 3 times a week for 10 weeks at an intensity of (80-85% HR max for 40 minutes and control group (group-II; n=23 remains sedentary during this period. Serum nitric oxide (NO, vascular endothelial growth factor levels (VEGF and blood pressures were measured before and after intervention. Results: A significant reduction in both systolic and diastolic blood pressure values by 9.5% and 7 % respectively, was seen after high intensity interval training which was accompanied by increase in NO and VEGF levels by 43.3% and 15.2 % respectively, while no significant change observed in the control group. Conclusion: High intensity interval training had obvious benefits in improving plasma No, VEGF concentrations and controlling hypertension in postmenopausal women.

  14. High-intensity erotic visual stimuli de-activate the primary visual cortex in women.

    Science.gov (United States)

    Huynh, Hieu K; Beers, Caroline; Willemsen, Antoon; Lont, Erna; Laan, Ellen; Dierckx, Rudi; Jansen, Monique; Sand, Michael; Weijmar Schultz, Willibrord; Holstege, Gert

    2012-06-01

    The primary visual cortex, Brodmann's area (BA 17), plays a vital role in basic survival mechanisms in humans. In most neuro-imaging studies in which the volunteers have to watch pictures or movies, the primary visual cortex is similarly activated independent of the content of the pictures or movies. However, in case the volunteers perform demanding non-visual tasks, the primary visual cortex becomes de-activated, although the amount of incoming visual sensory information is the same. Do low- and high-intensity erotic movies, compared to neutral movies, produce similar de-activation of the primary visual cortex? Brain activation/de-activation was studied by Positron Emission Tomography scanning of the brains of 12 healthy heterosexual premenopausal women, aged 18-47, who watched neutral, low- and high-intensity erotic film segments. We measured differences in regional cerebral blood flow (rCBF) in the primary visual cortex during watching neutral, low-intensity erotic, and high-intensity erotic film segments. Watching high-intensity erotic, but not low-intensity erotic movies, compared to neutral movies resulted in strong de-activation of the primary (BA 17) and adjoining parts of the secondary visual cortex. The strong de-activation during watching high-intensity erotic film might represent compensation for the increased blood supply in the brain regions involved in sexual arousal, also because high-intensity erotic movies do not require precise scanning of the visual field, because the impact is clear to the observer. © 2012 International Society for Sexual Medicine.

  15. High intensity polarization entangled source with a 2D nonlinear photonic crystal

    DEFF Research Database (Denmark)

    Wang, Qin

    2009-01-01

    We gave a proposal on how to use a piece of two-dimension (2D) nonlinear photonic crystal to generate a polarization entangled source. It provides not only has a high stability, but also a high entangled quality and a high intensity. Moreover, our scheme involves only practical experimental...

  16. Generalized Kapchinskij-Vladimirskij Distribution and Beam Matrix for Phase-Space Manipulations of High-Intensity Beams

    CERN Document Server

    Chung, Moses; Davidson, Ronald C; Groening, Lars; Xiao, Chen

    2016-01-01

    In an uncoupled linear lattice system, the Kapchinskij-Vladimirskij (KV) distribution, formulated on the basis of the single-particle Courant-Snyder (CS) invariants, has served as a fundamental theoretical basis for the analyses of the equilibrium, stability, and transport properties of high-intensity beams for the past several decades. Recent applications of high-intensity beams, however, require beam phase-space manipulations by intentionally introducing strong coupling. In this Letter, we report the full generalization of the KV model by including all of the linear (both external and space-charge) coupling forces, beam energy variations, and arbitrary emittance partition, which all form essential elements for phase-space manipulations. The new generalized KV model yields spatially uniform density profiles and corresponding linear self-field forces as desired. The corresponding matrix envelope equations and beam matrix for the generalized KV model provide important new theoretical tools for the detailed des...

  17. Influence to high-intensity intermittent and moderate-intensity continuous exercise on indices of cardio-inflammatory health in men

    Science.gov (United States)

    Santos, Carolina C.; Diniz, Tiego A.; Inoue, Daniela S.; Gerosa-Neto, José; Panissa, Valéria L.G.; Pimentel, Gustavo Duarte; Campos, Eduardo Z.; Hofmann, Peter; Lira, Fábio S.

    2016-01-01

    The aim of this study was to evaluate the influence to acute exercises performed in different intensities with volume equalized (5 km) on indices of cardio-inflammatory health. Twelve physically active male subjects (age, 23.22±5.47 years; height, 174.75±5.80 m; weight, 75.13±6.61 kg; maximal oxygen uptake, 52.92 mL/kg/min), after determination of peak oxygen uptake (VO2Peak) and the speed associated with VO2Peak (sVO2Peak), completed two randomly experimental trials: high-intensity intermittent exercise (HIIE: 1:1 at 100% sVO2Peak) and moderate-intensity continuous exercise (MICE: 70% sVO2Peak). Brain-derived neurotrophic factor (BDNF), adiponectin and plasminogen inhibitor-1 (PAI-1) data were analyzed pre, immediately, and 60 min after the exercise session. Statistical analysis comparisons between moments and between HIIE and MICE were performed using a mixed model and statistical and significance was set at healthy sportsmen, favoring an anti-atherogenic profile. PMID:28119886

  18. [Impact of personality on the alcohol withdrawal syndrome intensity: a preliminary study with the Cloninger's model].

    Science.gov (United States)

    Coton, X; Pinto, E; Reggers, J; Hansenne, M; Parent, M; Ansseau, M

    2007-01-01

    The personality of alcohol dependant patients as a factor influencing the intensity of the alcohol withdrawal syndrome has been seldom examined. Cloninger's biosocial model of personality describes four temperaments (novelty seeking, harm avoidance, reward dependence, persistence) which, except for persistence, are admittedly linked to specific central neurotransmitters, and three characters. Novelty seeking is linked with low levels of mesencephalic dopamine, harm avoidance with high levels of serotonin in the septo-hippocampic system and reward dependence with low levels of noradrenaline in the ascending pathways from the locus coeruleus to the limbic system. The same neurotransmitters pathways are known to be involved in alcohol withdrawal, with a decrease of dopaminergic activity in the mesolimbic system, a decrease of serotonergic activity in the nucleus accumbens and an increase of the noradrenergic system. In view of the similarities between the neurobiological systems involved in Cloninger's model and in the neurobiological changes occurring during the withdrawal period, one would expect to observe severe withdrawal symptoms more frequently for patients with high novelty seeking, low harm avoidance and low reward dependence. To test this hypothesis, alcohol dependent patients according to DSM IV classification criteria who have drunk in the last twenty four hours were included in the study and received a standardized withdrawal treatment. The withdrawal syndrome intensity was examined with repeated measures of CIWA-Ar, the scores of which were correlated with TCI-R. Twenty eight patients, between 30 et 65 years old and drinking 22,2 +/- 12 standard drinks per day were included. Antidepressant drugs, benzodiazepines and neuroleptics treatment introduced before hospitalisation were stopped or decreased as much as possible. A correlation matrix was carried out between all the variables which could influence withdrawal intensity (age at the hospitalisation, age

  19. Understanding transverse tune spectrum for high intensity ions beams at GSI SIS-18

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Rahul; Boine-Frankenheim, Oliver [GSI, Darmstadt (Germany); TEMF, TU Darmstadt (Germany); Forck, Peter; Kowina, Piotr; Kaufmann, Wolfgang; Lang, Kevin; Haseitl, Rainer [GSI, Darmstadt (Germany); Weiland, Thomas [TEMF, TU Darmstadt (Germany)

    2013-07-01

    Several experiments involving transverse tune spectra measurements were performed at GSI SIS-18 with various beam intensities to understand the effect of intensity on tune spectra. Besides the machine tune, the spectra provides information about the intensity dependent coherent and the incoherent space charge tune shift. The space charge tune shift is measured from a fit of the observed shifted positions of the measured head tail modes to the predictions of an analytic model. Additionally, each mode is temporally identified by using a novel excitation mechanism and fast sampling ADCs. The longitudinal structure of each head tail mode gives a direct measurement of chromaticity.

  20. Koolau dike complex, Oahu: intensity and origin of a sheeted-dike complex high in a Hawaiian volcanic edifice

    Energy Technology Data Exchange (ETDEWEB)

    Walker, G.P.L.

    1986-04-01

    The dike complex in the eroded Koolau tholeiitic shield volcano is unique among described dike swarms for its coherence, high dike-injection intensity, relatively uniform and non-Gaussian 50% to 65% intensity level, and lack of dike divergence. Parts are like a sheeted-dike complex, though high in an intraplate volcanic edifice. A model is proposed in which highly mobile tholeiitic magma, having considerable freedom to move through the strongly disjointed volcano, seeks zones in which it is gravitationally most stable. These zones are marginal parts of the dike complex, separating lavas having a lower-than-magmatic bulk density from a > 50% dike complex having a higher-than-magmatic bulk density. This model also explains the strong propensity for the magma of Kilauea volcano to remain underground (in a gravitationally stable zone). Magma erupts only when it vesiculates sufficiently; often, when it has degassed, some of it promptly plunges back toward the stable zone again.

  1. Statistical distribution of the optical intensity obtained using a Gaussian Schell model for space-to-ground link laser communications

    Science.gov (United States)

    Li, Mengnan; Tan, Liying; Ma, Jing; Yu, Siyuan; Yang, Qingbo; Wu, Jiajie

    2016-05-01

    Based on the characteristics of the laser device and the inevitable error of the processing technique, a laser beam emitted from a communication terminal can be represented by the Gaussian Schell model (GSM). In space-to-ground link laser communications, the optical intensity is affected by the source coherence parameter and the zenith angle. With full consideration of these two parameters, the statistical distribution model of the optical intensity with a GSM laser in both downlink and uplink is derived. The simulation results indicate that increasing the source coherence parameter has an effect on the statistical distribution of the optical intensity; this effect is highly similar to the effect of a larger zenith angle. The optical intensity invariably degrades with increasing source coherence parameter or zenith angle. The results of this work can promote the improvement of the redundancy design of a laser communication receiver system.

  2. Two weeks of moderate intensity continuous training, but not high intensity interval training increases insulin-stimulated intestinal glucose uptake.

    Science.gov (United States)

    Motiani, Kumail Kumar; Savolainen, Anna M; Eskelinen, Jari-Joonas; Toivanen, Jussi; Ishizu, Tamiko; Yli-Karjanmaa, Minna; Virtanen, Kirsi A; Parkkola, Riitta; Kapanen, Jukka; Gronroos, Tove J; Haaparanta-Solin, Merja; Solin, Olof; Savisto, Nina; Ahotupa, Markku; Löyttyniemi, Eliisa; Knuuti, Juhani; Nuutila, Pirjo; Kalliokoski, Kari K; Hannukainen, Jarna C

    2017-02-09

    Similar to muscles, the intestine is also insulin resistant in obese subjects and subjects with impaired glucose tolerance. Exercise training improves muscle insulin sensitivity, but its effects on intestinal metabolism are not known. We studied the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on intestinal glucose and free fatty acid uptake from circulation in humans. Twenty-eight healthy middle-aged sedentary men were randomized for two weeks of HIIT or MICT. Intestinal insulin-stimulated glucose uptake and fasting free fatty acid uptake from circulation were measured using positron emission tomography and [(18)F]FDG and [(18)F]FTHA. In addition, effects of HIIT and MICT on intestinal Glut2 and CD36 protein expression were studied in rats. Training improved aerobic capacity (p=0.001) and whole-body insulin sensitivity (p=0.04), but not differently between HIIT and MICT. Insulin-stimulated glucose uptake increased only after the MICT in the colon [HIIT=0%; MICT=37%] (p=0.02 for time*training) and tended to increase in the jejunum [HIIT=-4%; MICT=13%] (p=0.08 for time*training). Fasting free fatty acid uptake decreased in the duodenum in both groups [HIIT=-6%; MICT=-48%] (p=0.001 time) and tended to decrease in the colon in the MICT group [HIIT=0%; MICT=-38%] (p=0.08 for time*training). In rats, both training groups had higher Glut2 and CD36 expression compared to control animals. This study shows that already two weeks of MICT enhances insulin-stimulated glucose uptake while both training modes reduce fasting free fatty acid uptake in the intestine in healthy middle-aged men, providing an additional mechanism by which exercise training can improve whole body metabolism.

  3. Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise.

    Science.gov (United States)

    Peake, Jonathan M; Tan, Sok Joo; Markworth, James F; Broadbent, James A; Skinner, Tina L; Cameron-Smith, David

    2014-10-01

    This study investigated the effects of high-intensity interval training (HIIT) vs. work-matched moderate-intensity continuous exercise (MOD) on metabolism and counterregulatory stress hormones. In a randomized and counterbalanced order, 10 well-trained male cyclists and triathletes completed a HIIT session [81.6 ± 3.7% maximum oxygen consumption (V̇o2 max); 72.0 ± 3.2% peak power output; 792 ± 95 kJ] and a MOD session (66.7 ± 3.5% V̇o2 max; 48.5 ± 3.1% peak power output; 797 ± 95 kJ). Blood samples were collected before, immediately after, and 1 and 2 h postexercise. Carbohydrate oxidation was higher (P = 0.037; 20%), whereas fat oxidation was lower (P = 0.037; -47%) during HIIT vs. MOD. Immediately after exercise, plasma glucose (P = 0.024; 20%) and lactate (P HIIT vs. MOD, whereas total serum free fatty acid concentration was not significantly different (P = 0.33). Targeted gas chromatography-mass spectromtery metabolomics analysis identified and quantified 49 metabolites in plasma, among which 11 changed after both HIIT and MOD, 13 changed only after HIIT, and 5 changed only after MOD. Notable changes included substantial increases in tricarboxylic acid intermediates and monounsaturated fatty acids after HIIT and marked decreases in amino acids during recovery from both trials. Plasma adrenocorticotrophic hormone (P = 0.019), cortisol (P HIIT. Plasma norepinephrine (P = 0.11) and interleukin-6 (P = 0.20) immediately after exercise were not significantly different between trials. Plasma insulin decreased during recovery from both HIIT and MOD (P HIIT vs. MOD and highlight the value of targeted metabolomic analysis to provide more detailed insights into the metabolic demands of exercise.

  4. High-Intensity Interval Training as an Efficacious Alternative to Moderate-Intensity Continuous Training for Adults with Prediabetes

    Directory of Open Access Journals (Sweden)

    Mary E. Jung

    2015-01-01

    Full Text Available Aims. High-intensity interval training (HIIT leads to improvements in various markers of cardiometabolic health but adherence to HIIT following a supervised laboratory intervention has yet to be tested. We compared self-report and objective measures of physical activity after one month of independent exercise in individuals with prediabetes who were randomized to HIIT (n=15 or traditional moderate-intensity continuous training (MICT, n=17. Method. After completing 10 sessions of supervised training participants were asked to perform HIIT or MICT three times per week for four weeks. Results. Individuals in HIIT (89 ± 11% adhered to their prescribed protocol to a greater extent than individuals in MICT (71 ± 31% as determined by training logs completed over one-month follow-up (P = 0.05, Cohen’s d = 0.75. Minutes spent in vigorous physical activity per week measured by accelerometer were higher in HIIT (24 ± 18 as compared to MICT (11 ± 10 at one-month follow-up (P = 0.049, Cohen’s d = 0.92. Cardiorespiratory fitness and systolic blood pressure assessed at one-month follow-up were equally improved (P’s < 0.05. Conclusions. This study provides preliminary evidence that individuals with prediabetes can adhere to HIIT over the short-term and do so at a level that is greater than MICT.

  5. Spectral splitting of high order harmonics of ionizing gases irradiated with ultrashort intense laser pulses

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    -1199.[14]Lehemeier,H.J.,Leupacher,W.,Penzkofer,A.,Nonresonant third-order hyperpolarizability of rare gases and N2 determined by third harmonic generation,Opt.Comm.,1985,56(1): 67-72.[15]The index of rare gases for high harmonics can get from http//:cindy.lbl.gov.[16]Becker,W.,Long,S.,McIver,J.K.,High-harmonic production in a model atom with short-range potential,Phys.Rev.A,1990,41(7): 4112-4115.[17]Krause,J.L.,Schafer,K.J.,Kulander,K.C.,High-order harmonic generation from atoms and ions in the high intensity regimes,Phys.Rev.Lett.,1992,68(24): 3535-3538.[18]Krause,J.L.,Schafer,K.J.,Kulander,K.C.,Calculation of photoemission from atoms subject to intense laser fields,Phys.Rev.A,1992,45(7): 4998-5010.[19]Reed,V.C.,Burnett,K.,Ionization of atoms in intense laser pulses using the Krammers-Henneberger transformation,Phys.Rev.A,1990,45(5): 3152.[20]Constant,E.,Garzella,D.,Breger,P.et al.,Optimizing high harmonic generation in absorbing gases: Model and experiment,Phys.Rev.Lett.,1999,82(8):1668-1671.[21]Ranka,J.K.,Schirmen,R.W,Gaeta,A.L.,Observation of pulse splitting in nonlinear dispersive media,Phys.Rev.Lett.,77(1996): 3783.[22]Alfnao,R.R.ed.,The Supercontinuum Laser Source,New York: Springer-Verlag,1989.[23]Xu,Z.,Li,R.,Li,Z.et al.,Frontiers of Laser Physics and Quantum Optics,Berlin: Springer-Verlag,1999,57-76.[24]Xu Zhizhan,Wang Yingsong,Zhai Kan et al.,The experimental study of the high-order harmonic generation in Ar and Ne with 45 fs Ti:sapphire intense laser field,Science in China (in Chinese),Series A,1999,29(3): 270-275.

  6. Anthropometric, Sprint, and High-Intensity Running Profiles of English Academy Rugby Union Players by Position.

    Science.gov (United States)

    Darrall-Jones, Joshua D; Jones, Ben; Till, Kevin

    2016-05-01

    The purpose of this study was to evaluate the anthropometric, sprint, and high-intensity running profiles of English academy rugby union players by playing positions, and to investigate the relationships between anthropometric, sprint, and high-intensity running characteristics. Data were collected from 67 academy players after the off-season period and consisted of anthropometric (height, body mass, sum of 8 skinfolds [∑SF]), 40-m linear sprint (5-, 10-, 20-, and 40-m splits), the Yo-Yo intermittent recovery test level 1 (Yo-Yo IRTL-1), and the 30-15 intermittent fitness test (30-15 IFT). Forwards displayed greater stature, body mass, and ∑SF; sprint times and sprint momentum, with lower high-intensity running ability and sprint velocities than backs. Comparisons between age categories demonstrated body mass and sprint momentum to have the largest differences at consecutive age categories for forwards and backs; whereas 20-40-m sprint velocity was discriminate for forwards between under 16s, 18s, and 21s. Relationships between anthropometric, sprint velocity, momentum, and high-intensity running ability demonstrated body mass to negatively impact on sprint velocity (10 m; r = -0.34 to -0.46) and positively affect sprint momentum (e.g., 5 m; r = 0.85-0.93), with large to very large negative relationships with the Yo-Yo IRTL-1 (r = -0.65 to -0.74) and 30-15 IFT (r = -0.59 to -0.79). These findings suggest that there are distinct anthropometric, sprint, and high-intensity running ability differences between and within positions in junior rugby union players. The development of sprint and high-intensity running ability may be impacted by continued increases in body mass as there seems to be a trade-off between momentum, velocity, and the ability to complete high-intensity running.

  7. Effect of moderate- and high-intensity acute exercise on appetite in obese individuals

    DEFF Research Database (Denmark)

    Martins, Catia; Stensvold, Dorthe; Finlayson, Graham

    2015-01-01

    cycling (MICC) or short-duration HIIC (S-HIIC) (125 kcal) and a resting control condition on the appetite hormone responses, subjective feelings of appetite, energy intake (EI), and food reward in overweight/obese individuals. METHODS: This study is a randomized crossover study on 12 overweight/obese......, hunger or fullness ratings, EI, or food reward. CONCLUSIONS: Our findings suggest that, in overweight/obese individuals, isocaloric bouts of moderate- or high-intensity exercise lead to a similar appetite response. This strengthens previous findings in normal-weight individuals that acute exercise, even......PURPOSE: The effect of acute exercise, and exercise intensity, on appetite control in obese individuals requires further study. The aim of this study was to compare the effects of acute isocaloric bouts (250 kcal) of high-intensity intermittent cycling (HIIC) and moderate-intensity continuous...

  8. MODELLING OF SHORT DURATION RAINFALL (SDR INTENSITY EQUATIONS FOR ERZURUM

    Directory of Open Access Journals (Sweden)

    Serkan ŞENOCAK

    2007-01-01

    Full Text Available The scope of this study is to develop a rainfall intensity-duration-frequency (IDF equation for some return periods at Erzurum rainfall station. The maximum annual rainfall values for 5, 10, 15, 30 and 60 minutes are statistically analyzed for the period 1956 – 2004 by using some statistical distributions such as the Generalized Extreme Values (GEV, Gumbel, Normal, Two-parameter Lognormal, Three-parameter Lognormal, Gamma, Pearson type III and Log-Pearson type III distributions. ?2 goodness-of-fit test was used to choose the best statistical distribution among all distributions. IDF equation constants and coefficients of correlation (R for each emprical functions are calculated using nonlinear estimation method for each return periods (T = 2, 5, 10, 25, 50, 75 and 100 years. The most suitable IDF equation is observed that ( B max i (t = A/ t + C , except for T=100 years, because of the highest coefficients of correlation.

  9. Nuclear Structure at the Legnaro National Laboratories:. from High Intensity Stable to Radioactive Nuclear Beams

    Science.gov (United States)

    de Angelis, G.

    2007-04-01

    To understand the properties of a nucleus, apart from establishing the interaction between its components, it is necessary to determine the arrangement of the nucleons, i.e. the structure of a nucleus. So far our knowledge about the structure of nuclei is mostly limited to nuclei close to the valley of stability, or nuclei with a deficiency of neutrons, which can be produced in fusion-evaporation reactions with stable beams and stable targets. Future perspectives in nuclear structure rely on radioactive ion beams (RIB) as well as on high intensity beams of stable ions (HISB). A world wide effort is presently going on in order to built the next generation radioactive ion beam facilities like the FAIR and the EURISOL projects. The LNL are contributing to such development through the design study of the EURISOL project as well as through the design and construction of the intermediate facility SPES. Concerning the instrumentation, particularly powerful is the combination of large acceptance spectrometers with highly segmented γ-detector arrays. An example is the CLARA γ-ray detector array coupled with the PRISMA spectrometer at the Legnaro National Laboratories (LNL). The physics aims achievable with such device complement studies performed with current radioactive beam (RIB) facilities. With this set-up we have recently investigated the stability of the N=50 shell closure. Here the comparison of the experimental data with shell model calculations seems to indicate a persistence of the N=50 shell gap down to Z=31. Also the study of proton rich nuclei can strongly benefit from the use of high intensity stable beams using fusion evaporation reactions at energies close to the Coulomb barrier. Future perspectives at LNL are based on an increase in intensity as well as on the availability of heavy ion species. Moreover a new ISOL facility (SPES) dedicated to the production and acceleration of radioactive neutron rich species is now under development at LNL. Among the new

  10. Psychological skills training as a way to enhance an athlete's performance in high-intensity sports.

    Science.gov (United States)

    Birrer, D; Morgan, G

    2010-10-01

    The importance of psychological skills training (PST) in the development of athletic performance is widely recognized. This paper is a comprehensive review of PST in elite sports, with a special focus on high-intensity sports (HIS). The reviewed literature showed a lack of convincing evidence and theoretical underpinning concerning traditional psychological skills to enhance performance in HIS. Therefore, a model with three conceptual levels (psychological demands, skills and techniques) is presented. The model facilitates the identification of the psychological demands of a specific sport, which in turn enables distinguishing which psychological skills are required. This allows an expert to choose psychological techniques to improve the athlete's psychological skill. Considerations based on our model and the limited HIS-related literature available revealed self-skills, personal development and life skills, arousal-regulation skills, volitional skills, motivational skills and recovery skills as the most important skills to address in order to enhance performance. Development of harmonious passion, in-practice integration of volitional strategies, use of associative attentional techniques, pain management techniques, use of the mindfulness-acceptance approach and the facilitative interpretation of cognitive and somatic sensations are regarded as suitable to meet the psychological demands of HIS. They are recommended for systematic application by athletes and coaches. © 2010 John Wiley & Sons A/S.

  11. Nutritional strategies to support adaptation to high-intensity interval training in team sports.

    Science.gov (United States)

    Gibala, Martin J

    2013-01-01

    Team sports are characterized by intermittent high-intensity activity patterns. Typically, play consists of short periods of very intense or all-out efforts interspersed with longer periods of low-intensity activity. Fatigue is a complex, multi-factorial process, but intense intermittent exercise performance can potentially be limited by reduced availability of substrates stored in skeletal muscle and/or metabolic by-products associated with fuel breakdown. High-intensity interval training (HIT) has been shown to induce adaptations in skeletal muscle that enhance the capacity for both oxidative and non-oxidative metabolism. Nutrient availability is a potent modulator of many acute physiological responses to exercise, including various molecular signaling pathways that are believed to regulate cellular adaptation to training. Several nutritional strategies have also been reported to acutely alter metabolism and enhance intermittent high-intensity exercise performance. However, relatively little is known regarding the effect of chronic interventions, and whether supplementation over a period of weeks or months augments HIT-induced physiological remodeling and promotes greater performance adaptations. Theoretically, a nutritional intervention could augment HIT adaptation by improving energy metabolism during exercise, which could facilitate greater total work and an enhanced chronic training stimulus, or promoting some aspect of the adaptive response during recovery, which could lead to enhanced physiological adaptations over time.

  12. Predictive models for pressure ulcers from intensive care unit electronic health records using Bayesian networks.

    Science.gov (United States)

    Kaewprag, Pacharmon; Newton, Cheryl; Vermillion, Brenda; Hyun, Sookyung; Huang, Kun; Machiraju, Raghu

    2017-07-05

    We develop predictive models enabling clinicians to better understand and explore patient clinical data along with risk factors for pressure ulcers in intensive care unit patients from electronic health record data. Identifying accurate risk factors of pressure ulcers is essential to determining appropriate prevention strategies; in this work we examine medication, diagnosis, and traditional Braden pressure ulcer assessment scale measurements as patient features. In order to predict pressure ulcer incidence and better understand the structure of related risk factors, we construct Bayesian networks from patient features. Bayesian network nodes (features) and edges (conditional dependencies) are simplified with statistical network techniques. Upon reviewing a network visualization of our model, our clinician collaborators were able to identify strong relationships between risk factors widely recognized as associated with pressure ulcers. We present a three-stage framework for predictive analysis of patient clinical data: 1) Developing electronic health record feature extraction functions with assistance of clinicians, 2) simplifying features, and 3) building Bayesian network predictive models. We evaluate all combinations of Bayesian network models from different search algorithms, scoring functions, prior structure initializations, and sets of features. From the EHRs of 7,717 ICU patients, we construct Bayesian network predictive models from 86 medication, diagnosis, and Braden scale features. Our model not only identifies known and suspected high PU risk factors, but also substantially increases sensitivity of the prediction - nearly three times higher comparing to logistical regression models - without sacrificing the overall accuracy. We visualize a representative model with which our clinician collaborators identify strong relationships between risk factors widely recognized as associated with pressure ulcers. Given the strong adverse effect of pressure ulcers

  13. High signal intensity of the septum pellucidum at MR imaging; Significance in hydrocephalus

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Jeong Hee; Kim, Eun Ha; Chung, Chun Phil; Kim, Chang Soo [Maryknoll Hospital, Pusan (Korea, Republic of)

    1994-05-15

    To evaluate the significance of high signal intensity of the septum pellucidum in hydrocephalus on proton density-weighted brain MR images. Authors reviewed the MR images of 418 cases of patients with normal (175 case), hydrocephalic(35 cases), atrophic(58 cases), and other groups(150 cases) retrospectively. We analyzed the signal intensity of the septum pellucidum in the normal group and the incidences of high signal intensities of periventricular area of frontal horn of lateral ventricle(area 1), periventricular area except area 1 (area 2), callososeptal area(area 3), and septum pellucidum(area 4) in the normal and abnormal groups. In the normal group, the septum pellucidum was isointense to the head of caudate nucleus on proton density-weighted image. High signal intensity of the septum pellucidum was seen in 31 cases (22 cases of hydrocephalus, 5 cases of brain atrophy, and 4 cases of others), and showed high specificity(91.4%) for hydrocephalus in spite of low sensitivity(62.9%), as compared with periventricular hyperintensities of other areas. High signal intensity of the septum pellucidum on proton density- weighted image may be caused by transependymal CSF migration in the patients with hydrocephalus, and considered as an additional finding of hydrocephalus in the cases of ventriculomegaly.

  14. Examining diurnal cycle influences on convective intensity in idealized cloud resolving model simulations

    Science.gov (United States)

    Hansen, Z.; Back, L. E.

    2016-12-01

    There is a large observed contrast in the lightning flash rate per unit precipitation between land and ocean in the tropics. Higher lightning flash rates are associated with faster updraft velocities, and thus greater lightning flash rate per unit precipitation is associated with faster updrafts per unit precipitation, a clear measure of convective intensity. As it is the land regions exhibiting the greater lightning flash rate per unit precipitation, there is an expectation that tropical land areas exhibit greater convective intensity than tropical oceans. Using a cloud resolving model (CRM) we tested whether the application of a diurnal cycle in sea surface temperature (SST) over a portion of the domain would result in faster updrafts per unit precipitation over that domain. We applied a Bernoulli sampling technique to the area of oscillating SST to give it the same effective mean precipitation as the fixed SST area. Once the mean precipitation values were equal, it was found that there were no differences in high intensity updraft velocity that could be associated with lightning flash rate per unit precipitation variations in the real world.

  15. The Effects of High-Intensity versus Low-Intensity Resistance Training on Leg Extensor Power and Recovery of Knee Function after ACL-Reconstruction

    DEFF Research Database (Denmark)

    Bieler, Theresa; Sobol, Nanna Aue; Andersen, Lars L

    2014-01-01

    OBJECTIVE: Persistent weakness is a common problem after anterior cruciate ligament- (ACL-) reconstruction. This study investigated the effects of high-intensity (HRT) versus low-intensity (LRT) resistance training on leg extensor power and recovery of knee function after ACL-reconstruction. METH...

  16. High-Intensity Intermittent Swimming Improves Cardiovascular Health Status for Women with Mild Hypertension

    Directory of Open Access Journals (Sweden)

    Magni Mohr

    2014-01-01

    Full Text Available To test the hypothesis that high-intensity swim training improves cardiovascular health status in sedentary premenopausal women with mild hypertension, sixty-two women were randomized into high-intensity (n=21; HIT, moderate-intensity (n=21; MOD, and control groups (n=20; CON. HIT performed 6–10 × 30 s all-out swimming interspersed by 2 min recovery and MOD swam continuously for 1 h at moderate intensity for a 15-week period completing in total 44±1 and 43±1 sessions, respectively. In CON, all measured variables were similar before and after the intervention period. Systolic BP decreased (P<0.05 by 6±1 and 4±1 mmHg in HIT and MOD; respectively. Resting heart rate declined (P<0.05 by 5±1 bpm both in HIT and MOD, fat mass decreased (P<0.05 by 1.1±0.2 and 2.2±0.3 kg, respectively, while the blood lipid profile was unaltered. In HIT and MOD, performance improved (P<0.05 for a maximal 10 min swim (13±3% and 22±3%, interval swimming (23±3% and 8±3%, and Yo-Yo IE1 running performance (58±5% and 45±4%. In conclusion, high-intensity intermittent swimming is an effective training strategy to improve cardiovascular health and physical performance in sedentary women with mild hypertension. Adaptations are similar with high- and moderate-intensity training, despite markedly less total time spent and distance covered in the high-intensity group.

  17. Dynamics of cavitation clouds within a high-intensity focused ultrasonic beam

    NARCIS (Netherlands)

    Lu, Yuan; Katz, Joseph; Prosperetti, Andrea

    2013-01-01

    In this experimental study, we generate a 500 kHz high-intensity focused ultrasonic beam, with pressure amplitude in the focal zone of up to 1.9 MPa, in initially quiescent water. The resulting pressure field and behavior of the cavitation bubbles are measured using high-speed digital in-line hologr

  18. Optimizing Planning and Delivery of High-Precision Robotic Radiotherapy and Intensity-Modulated Proton Therapy

    NARCIS (Netherlands)

    S. van de Water (Steven)

    2015-01-01

    markdownabstract__Abstract__ High-precision robotic radiotherapy and intensity-modulated proton therapy (IMPT) are two relatively new radiotherapy techniques that particularly aim at a highly localized delivery of a curative dose to the tumor, while achieving excellent sparing of the surrounding

  19. Optimizing Planning and Delivery of High-Precision Robotic Radiotherapy and Intensity-Modulated Proton Therapy

    NARCIS (Netherlands)

    S. van de Water (Steven)

    2015-01-01

    markdownabstract__Abstract__ High-precision robotic radiotherapy and intensity-modulated proton therapy (IMPT) are two relatively new radiotherapy techniques that particularly aim at a highly localized delivery of a curative dose to the tumor, while achieving excellent sparing of the surrounding he

  20. Modeling jointly low, moderate, and heavy rainfall intensities without a threshold selection

    KAUST Repository

    Naveau, Philippe

    2016-04-09

    In statistics, extreme events are often defined as excesses above a given large threshold. This definition allows hydrologists and flood planners to apply Extreme-Value Theory (EVT) to their time series of interest. Even in the stationary univariate context, this approach has at least two main drawbacks. First, working with excesses implies that a lot of observations (those below the chosen threshold) are completely disregarded. The range of precipitation is artificially shopped down into two pieces, namely large intensities and the rest, which necessarily imposes different statistical models for each piece. Second, this strategy raises a nontrivial and very practical difficultly: how to choose the optimal threshold which correctly discriminates between low and heavy rainfall intensities. To address these issues, we propose a statistical model in which EVT results apply not only to heavy, but also to low precipitation amounts (zeros excluded). Our model is in compliance with EVT on both ends of the spectrum and allows a smooth transition between the two tails, while keeping a low number of parameters. In terms of inference, we have implemented and tested two classical methods of estimation: likelihood maximization and probability weighed moments. Last but not least, there is no need to choose a threshold to define low and high excesses. The performance and flexibility of this approach are illustrated on simulated and hourly precipitation recorded in Lyon, France.

  1. Modeling jointly low, moderate, and heavy rainfall intensities without a threshold selection

    Science.gov (United States)

    Naveau, Philippe; Huser, Raphael; Ribereau, Pierre; Hannart, Alexis

    2016-04-01

    In statistics, extreme events are often defined as excesses above a given large threshold. This definition allows hydrologists and flood planners to apply Extreme-Value Theory (EVT) to their time series of interest. Even in the stationary univariate context, this approach has at least two main drawbacks. First, working with excesses implies that a lot of observations (those below the chosen threshold) are completely disregarded. The range of precipitation is artificially shopped down into two pieces, namely large intensities and the rest, which necessarily imposes different statistical models for each piece. Second, this strategy raises a nontrivial and very practical difficultly: how to choose the optimal threshold which correctly discriminates between low and heavy rainfall intensities. To address these issues, we propose a statistical model in which EVT results apply not only to heavy, but also to low precipitation amounts (zeros excluded). Our model is in compliance with EVT on both ends of the spectrum and allows a smooth transition between the two tails, while keeping a low number of parameters. In terms of inference, we have implemented and tested two classical methods of estimation: likelihood maximization and probability weighed moments. Last but not least, there is no need to choose a threshold to define low and high excesses. The performance and flexibility of this approach are illustrated on simulated and hourly precipitation recorded in Lyon, France.

  2. Markov modulated Poisson process models incorporating covariates for rainfall intensity.

    Science.gov (United States)

    Thayakaran, R; Ramesh, N I

    2013-01-01

    Time series of rainfall bucket tip times at the Beaufort Park station, Bracknell, in the UK are modelled by a class of Markov modulated Poisson processes (MMPP) which may be thought of as a generalization of the Poisson process. Our main focus in this paper is to investigate the effects of including covariate information into the MMPP model framework on statistical properties. In particular, we look at three types of time-varying covariates namely temperature, sea level pressure, and relative humidity that are thought to be affecting the rainfall arrival process. Maximum likelihood estimation is used to obtain the parameter estimates, and likelihood ratio tests are employed in model comparison. Simulated data from the fitted model are used to make statistical inferences about the accumulated rainfall in the discrete time interval. Variability of the daily Poisson arrival rates is studied.

  3. Is Moderate Intensity Exercise Training Combined with High Intensity Interval Training More Effective at Improving Cardiorespiratory Fitness than Moderate Intensity Exercise Training Alone?

    Directory of Open Access Journals (Sweden)

    Brendon H. Roxburgh, Paul B. Nolan, Ryan M. Weatherwax, Lance C. Dalleck

    2014-09-01

    Full Text Available The purpose of this study was to compare the effectiveness of either continuous moderate intensity exercise training (CMIET alone vs. CMIET combined with a single weekly bout of high intensity interval training (HIIT on cardiorespiratory fitness. Twenty nine sedentary participants (36.3 ± 6.9 yrs at moderate risk of cardiovascular disease were recruited for 12 weeks of exercise training on a treadmill and cycle ergometer. Participants were randomised into three groups: CMIET + HIIT (n = 7; 8-12 x 60 sec at 100% VO2max, 150 sec active recovery, CMIET (n = 6; 30 min at 45-60% oxygen consumption reserve (VO2R and a sedentary control group (n = 7. Participants in the CMIET + HIIT group performed a single weekly bout of HIIT and four weekly sessions of CMIET, whilst the CMIET group performed five weekly CMIET sessions. Probabilistic magnitude-based inferences were determined to assess the likelihood that the true value of the effect represents substantial change. Relative VO2max increased by 10.1% (benefit possible relative to control in in the CMIET + HIIT group (32.7 ± 9.2 to 36.0 ± 11.5 mL·kg-1·min-1 and 3.9% (benefit possible relative to control in the CMIET group (33.2 ± 4.0 to 34.5 ± 6.1 mL·kg-1·min-1, whilst there was a 5.7% decrease in the control group (30.0 ± 4.6 to 28.3 ± 6.5 mL·kg-1·min-1. It was ‘unclear’ if a clinically significant difference existed between the effect of CMIET + HIIT and CMIET on the change in VO2max. Both exercising groups showed clinically meaningful improvements in VO2max. Nevertheless, it remains ‘unclear’ whether one type of exercise training regimen elicits a superior improvement in cardiorespiratory fitness relative to its counterpart.

  4. Enhancement of Skeletal Muscle in Aged Rats Following High-Intensity Stretch-Shortening Contraction Training.

    Science.gov (United States)

    Rader, Erik P; Naimo, Marshall A; Layner, Kayla N; Triscuit, Alyssa M; Chetlin, Robert D; Ensey, James; Baker, Brent A

    2016-08-03

    Exercise is the most accessible, efficacious, and multifactorial intervention to improve health and treat chronic disease. High-intensity resistance exercise, in particular, also maximizes skeletal muscle size and strength-outcomes crucial at advanced age. However, such training is capable of inducing muscle maladaptation when misapplied at old age. Therefore, characterization of parameters (e.g., mode and frequency) that foster adaptation is an active research area. To address this issue, we utilized a rodent model that allowed training at maximal intensity in terms of muscle activation and tested the hypothesis that muscles of old rats adapt to stretch-shortening contraction (SSC) training, provided the training frequency is sufficiently low. At termination of training, normalized muscle mass (i.e., muscle mass divided by tibia length) and muscle quality (isometric force divided by normalized muscle mass) were determined. For young rats, normalized muscle mass increased by ∼20% regardless of training frequency. No difference was observed for muscle quality values after 2 days versus 3 days per week training (0.65 ± 0.09 N/mg/mm vs. 0.59 ± 0.05 N/mg/mm, respectively). For old rats following 3 days per week training, normalized muscle mass was unaltered and muscle quality was 30% lower than young levels. Following 2 days per week training at old age, normalized muscle mass increased by 17% and muscle quality was restored to young levels. To investigate this enhanced response, oxidative stress was assessed by lipid peroxidation quantification. For young rats, lipid peroxidation levels were unaltered by training. With aging, baseline levels of lipid peroxidation increased by 1.5-fold. For old rats, only 2 days per week training decreased lipid peroxidation to levels indistinguishable from young values. These results imply that, appropriately scheduled high-intensity SSC training at old age is capable of restoring muscle to a younger phenotype in terms

  5. An estimate of maintenance efficiency in Brown-Proschan imperfect repair model with bathtub failure intensity

    Directory of Open Access Journals (Sweden)

    Makram Krit

    2012-06-01

    Full Text Available Purpose: Estimate the maintenance efficiency in the Brown-Proschan model with the bathtub failure intensity.Design/methodology/approach: Empirical research through which we propose a framework to establish the characteristics of failure process and its influence on maintenance process.Findings: The main contribution of the present study is the reformulation of the Brown and Proschan model using the bathtub failure intensityPractical implications: Our model is defined by BP reformulation one using bathtub failure intensity. This form of intensity is presented like superposition of two NHPP and Homogeneous Poisson one.Originality/value: This is the follow on research on the study that employed the power-law-process type of failure intensity.

  6. High Intensity Interval- vs Moderate Intensity- Training for Improving Cardiometabolic Health in Overweight or Obese Males: A Randomized Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Gordon Fisher

    Full Text Available To compare the effects of six weeks of high intensity interval training (HIIT vs continuous moderate intensity training (MIT for improving body composition, insulin sensitivity (SI, blood pressure, blood lipids, and cardiovascular fitness in a cohort of sedentary overweight or obese young men. We hypothesized that HIIT would result in similar improvements in body composition, cardiovascular fitness, blood lipids, and SI as compared to the MIT group, despite requiring only one hour of activity per week compared to five hours per week for the MIT group.28 sedentary overweight or obese men (age, 20 ± 1.5 years, body mass index 29.5 ± 3.3 kg/m2 participated in a six week exercise treatment. Participants were randomly assigned to HIIT or MIT and evaluated at baseline and post-training. DXA was used to assess body composition, graded treadmill exercise test to measure cardiovascular fitness, oral glucose tolerance to measure SI, nuclear magnetic resonance spectroscopy to assess lipoprotein particles, and automatic auscultation to measure blood pressure.A greater improvement in VO2peak was observed in MIT compared to HIIT (11.1% vs 2.83%, P = 0.0185 in the complete-case analysis. No differences were seen in the intention to treat analysis, and no other group differences were observed. Both exercise conditions were associated with temporal improvements in % body fat, total cholesterol, medium VLDL, medium HDL, triglycerides, SI, and VO2peak (P < 0.05.Participation in HIIT or MIT exercise training displayed: 1 improved SI, 2 reduced blood lipids, 3 decreased % body fat, and 4 improved cardiovascular fitness. While both exercise groups led to similar improvements for most cardiometabolic risk factors assessed, MIT led to a greater improvement in overall cardiovascular fitness. Overall, these observations suggest that a relatively short duration of either HIIT or MIT training may improve cardiometabolic risk factors in previously sedentary overweight or

  7. High Intensity Interval- vs Moderate Intensity- Training for Improving Cardiometabolic Health in Overweight or Obese Males: A Randomized Controlled Trial.

    Science.gov (United States)

    Fisher, Gordon; Brown, Andrew W; Bohan Brown, Michelle M; Alcorn, Amy; Noles, Corey; Winwood, Leah; Resuehr, Holly; George, Brandon; Jeansonne, Madeline M; Allison, David B

    2015-01-01

    To compare the effects of six weeks of high intensity interval training (HIIT) vs continuous moderate intensity training (MIT) for improving body composition, insulin sensitivity (SI), blood pressure, blood lipids, and cardiovascular fitness in a cohort of sedentary overweight or obese young men. We hypothesized that HIIT would result in similar improvements in body composition, cardiovascular fitness, blood lipids, and SI as compared to the MIT group, despite requiring only one hour of activity per week compared to five hours per week for the MIT group. 28 sedentary overweight or obese men (age, 20 ± 1.5 years, body mass index 29.5 ± 3.3 kg/m2) participated in a six week exercise treatment. Participants were randomly assigned to HIIT or MIT and evaluated at baseline and post-training. DXA was used to assess body composition, graded treadmill exercise test to measure cardiovascular fitness, oral glucose tolerance to measure SI, nuclear magnetic resonance spectroscopy to assess lipoprotein particles, and automatic auscultation to measure blood pressure. A greater improvement in VO2peak was observed in MIT compared to HIIT (11.1% vs 2.83%, P = 0.0185) in the complete-case analysis. No differences were seen in the intention to treat analysis, and no other group differences were observed. Both exercise conditions were associated with temporal improvements in % body fat, total cholesterol, medium VLDL, medium HDL, triglycerides, SI, and VO2peak (P training displayed: 1) improved SI, 2) reduced blood lipids, 3) decreased % body fat, and 4) improved cardiovascular fitness. While both exercise groups led to similar improvements for most cardiometabolic risk factors assessed, MIT led to a greater improvement in overall cardiovascular fitness. Overall, these observations suggest that a relatively short duration of either HIIT or MIT training may improve cardiometabolic risk factors in previously sedentary overweight or obese young men, with no clear advantage between these

  8. Meeting standards of high-quality intensive care unit palliative care: Clinical performance and predictors

    Science.gov (United States)

    Penrod, Joan D.; Pronovost, Peter J.; Livote, Elayne E.; Puntillo, Kathleen A.; Walker, Amy S.; Wallenstein, Sylvan; Mercado, Alice F.; Swoboda, Sandra M.; Ilaoa, Debra; Thompson, David A.; Nelson, Judith E.

    2012-01-01

    Objectives High-quality care for intensive care unit patients and families includes palliative care. To promote performance improvement, the Agency for Healthcare Research and Quality’s National Quality Measures Clearinghouse identified nine evidence-based processes of intensive care unit palliative care (Care and Communication Bundle) that are measured through review of medical record documentation. We conducted this study to examine how frequently the Care and Communication Bundle processes were performed in diverse intensive care units and to understand patient factors that are associated with such performance. Design Prospective, multisite, observational study of performance of key intensive care unit palliative care processes. Settings A surgical intensive care unit and a medical intensive care unit in two different large academic health centers and a medical-surgical intensive care unit in a medium-sized community hospital. Patients Consecutive adult patients with length of intensive care unit stay ≥5 days. Interventions None. Measurements and Main Results Between November 2007 and December 2009, we measured performance by specified day after intensive care unit admission on nine care process measures: identify medical decision-maker, advance directive and resuscitation preference, distribute family information leaflet, assess and manage pain, offer social work and spiritual support, and conduct interdisciplinary family meeting. Multivariable regression analysis was used to determine predictors of performance of five care processes. We enrolled 518 (94.9%) patients and 336 (83.6%) family members. Performances on pain assessment and management measures were high. In contrast, interdisciplinary family meetings were documented for <20% of patients by intensive care unit day 5. Performance on other measures ranged from 8% to 43%, with substantial variation across and within sites. Chronic comorbidity burden and site were the most consistent predictors of care

  9. 高烈度地震区公路填方路基大型振动台模型试验%Large-scale Shaking Table Model Test for Fill Subgrade of Highway in High-intensity Earthquake Area

    Institute of Scientific and Technical Information of China (English)

    李金贝; 张鸿儒; 李志强

    2011-01-01

    In order to study the seismic safety of highway fill subgrade, according to the test requirement, a large-scale shaking table model test scheme was designed for fill subgrade. First, the vibration system, the design of model box and the data acquisition system were introduced, the similar relation between treatment of the model boundary condition and fill subgrade model was analyzed, and the similarity constants are determined combining the test characteristics. The model material was determined by using the equivalent substitution method to deal with the similar gradation. Meanwhile, the arrangement of sensors was selected based on the numerical analysis of dynamic response characteristics. Finally, the loading scheme of the model test was prepared according to its purpose. The test result shows that the design of large-scale shaking table model test is feasible, and the purpose of the shaking table test was achieved.%为了深入研究公路填方路基的抗震安全,根据试验要求对填方路基进行了大型振动台模型试验方案设计.方案设计中首先介绍了振动台台阵体系、模型箱的设计和数据采集系统等试验装置;然后分析了填方路基振动台模型边界条件的处理和填方路基模型的相似关系,并在已有研究成果基础上结合本次试验特性确定了模型的相似常数,通过采用等量代替法来处理模型材料的相似级配,最终确定了模拟模型路基的试验材料.同时,在对填方路基数值分析的基础上,根据路基数值模型的动力反应特性确定了振动台试验测点的布置方案.最后,根据模型试验目的,编制了模型试验的加载制度.试验结果表明,填方路基的大型振动台模型试验设计方案可行,达到了振动台试验的目的.

  10. High-intensity interval training and athletic performance in Taekwondo athletes.

    Science.gov (United States)

    Monks, Lynne; Seo, Myong-Won; Kim, Hyun-Bae; Jung, Hyun C; Song, Jong K

    2017-10-01

    The purpose of this study was to determine the effects of high-intensity interval training (HIIT) on athletic performance in Taekwondo athletes. Thirty-three male and female collegiate Taekwondo athletes were randomly divided into a HIIT group (N.=16) or a high-intensity continuous running (HICR) group (N.=17). The HIIT group undertook training of high-intensity sprints interspersed with active rest periods whilst the HICR group participated in high-intensity running for a continuous period. Both groups completed 11 sessions over 4 weeks. Physique, body composition, Wingate anaerobic test and VO2max test were measured. The vertical jump test, agility T-test and sit-ups were used to assess physical fitness. Repeated measures ANCOVAs with sex as a covariate were applied and significant level was set at 0.05. Following 11 sessions of training, significant improvements in anaerobic peak power (PTaekwondo competition performance in collegiate Taekwondo athletes. This could inform the future planning of Taekwondo athletes' pre-competition training, specifically the influence of training intensity on anaerobic capacity.

  11. Warm-up strategy and high-intensity endurance performance in trained cyclists

    DEFF Research Database (Denmark)

    Christensen, Peter Møller; Bangsbo, Jens

    2015-01-01

    PURPOSE: To evaluate the influence of warm-up exercise intensity and subsequent recovery on intense endurance performance, selected blood variables and the VO2 response. METHODS: Twelve highly trained male cyclists (VO2-max: 72.4±8.0·mL/min/kg, incremental-test peak power output (iPPO): 432±31 W......; means±SD) performed three warm-up strategies lasting 20 min before a 4-min maximal performance test (PT). Strategies consisted of moderate intensity exercise (50%iPPO) followed by 6 min of recovery (MOD6) or progressive-high intensity exercise (10-100%iPPO and 2x20-s sprints) followed by recovery for 6...... to HI20 (7.85±0.82 L; P=0.008) and MOD6 (7.90±0.74 L; P=0.012). CONCLUSIONS: Warm-up exercise including race-pace and sprint intervals combined with short recovery can reduce subsequent performance in a 4-min maximal test in highly trained cyclists. Thus, a reduced time at high exercise intensity...

  12. Study of ultra-high gradient wakefield excitation by intense ultrashort laser pulses in plasma

    Science.gov (United States)

    Kotaki, Hideyuki; Kando, Masaki; Oketa, Takatsugu; Masuda, Shinichi; Koga, James K.; Kondo, Shuji; Kanazawa, Shuhei; Yokoyama, Takashi; Matoba, Toru; Nakajima, Kazuhisa

    2002-10-01

    We investigate a laser wakefield excited by intense laser pulses, and the possibility of generating an intense bright electron source by an intense laser pulse. The coherent wakefield excited by 2 TW, 50 fs laser pulses in a gas-jet plasma around 1018 cm-3 is measured with a time-resolved frequency domain interferometer (FDI). The results show an accelerating wakefield excitation of 20 GeV/m with good coherency. This is the first time-resolved measurement of laser wakefield excitation in a gas-jet plasma. The experimental results agree with the simulation results and linear theory. The pump-probe interferometer system of FDI will be modified to the optical injection system as a relativistic electron beam injector. In 1D particle in cell simulation we obtain results of high quality intense electron beam generation.

  13. High-quality binary fringe generation via joint optimization on intensity and phase

    Science.gov (United States)

    Xiao, Yi; Li, Youfu

    2017-10-01

    There have been active studies on optimized dithering techniques to improve 3D shape measurement quality with defocused projectors. These techniques optimize the fringe quality in either phase domain or intensity domain according to their objective functions. Phase based optimization is direct and effective, but is sensitive to projector defocus levels. Intensity based optimization is robust to projector defocus levels, but it does not fully improve the phase quality. This paper presents a joint optimization technique to combine the merits of both the intensity and phase based optimization, which includes a pre-intensity optimization and a further optimization based on the synthesized error function. Then this technique is implemented in two frameworks, the whole-fringe optimization and the best-patch optimization, to generate binary fringe patterns. Both simulations and experiments show that the proposed technique can generate binary fringe patterns with high phase quality and robustness to projector defocus levels.

  14. Low-intensity red and infrared laser effects at high fluences on Escherichia coli cultures

    Energy Technology Data Exchange (ETDEWEB)

    Barboza, L.L.; Campos, V.M.A.; Magalhaes, L.A.G. [Instituto de Biologia Roberto Alcantara Gomes, Rio de Janeiro, RJ (Brazil). Departamento de Biofisica e Biometria; Paoli, F. [Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG (Brazil). Departamento de Morfologia; Fonseca, A.S., E-mail: adnfonseca@ig.com.br [Universidade Federal do Estado do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Departamento de Ciencias Fisiologicas

    2015-10-15

    Semiconductor laser devices are readily available and practical radiation sources providing wavelength tenability and high monochromaticity. Low-intensity red and near-infrared lasers are considered safe for use in clinical applications. However, adverse effects can occur via free radical generation, and the biological effects of these lasers from unusually high fluences or high doses have not yet been evaluated. Here, we evaluated the survival, filamentation induction and morphology of Escherichia coli cells deficient in repair of oxidative DNA lesions when exposed to low-intensity red and infrared lasers at unusually high fluences. Cultures of wild-type (AB1157), endonuclease III-deficient (JW1625-1), and endonuclease IV-deficient (JW2146-1) E. coli, in exponential and stationary growth phases, were exposed to red and infrared lasers (0, 250, 500, and 1000 J/cm{sup 2}) to evaluate their survival rates, filamentation phenotype induction and cell morphologies. The results showed that low-intensity red and infrared lasers at high fluences are lethal, induce a filamentation phenotype, and alter the morphology of the E. coli cells. Low-intensity red and infrared lasers have potential to induce adverse effects on cells, whether used at unusually high fluences, or at high doses. Hence, there is a need to reinforce the importance of accurate dosimetry in therapeutic protocols. (author)

  15. High-intensity exercise training produces morphological and biochemical changes in adrenal gland of mice.

    Science.gov (United States)

    Bartalucci, A; Ferrucci, M; Fulceri, F; Lazzeri, G; Lenzi, P; Toti, L; Serpiello, F R; La Torre, A; Gesi, M

    2012-06-01

    The effects of training are dependent on complex, adaptive changes which are induced by acute physical exercise at different levels. In particular, evidence shows that the hypothalamus-pituitary-adrenocortical axis, as well as the sympatho-adrenomedullary system, is mainly involved in mediating the physiological effects of physical exercise. The aim of the present study was to investigate, through a morphological and biochemical approach, the effects of training on the adrenal gland of mice, following two different protocols consisting of either low- or high-intensity training. Mice were run daily on a motorised treadmill for 8 weeks, at a velocity corresponding to 60% (low-intensity exercise) or 90% (high-intensity exercise) of the maximal running velocity previously determined by an incremental exercise test. We found that physical exercise produced an increase in the adrenal gland size compared with the control (sedentary) mice. The increase was 31.04% for mice that underwent high-intensity exercise and 10.08% for mice that underwent low intensity exercise, and this appeared to be the result of an increase in the area of both the adrenal cortex and adrenal medulla. Morphological analysis of the adrenal cortex showed that both types of exercise produced an increase in cytoplasmic vacuoles in steroidogenic cells, appearing more abundant after high-intensity exercise. No change was found in the reticulate zone. In the adrenal medulla, despite the absence of morphological changes, immunohistochemistry for tyrosine hydroxylase, dopamine β-hydroxylase and phenyl-ethanolamine-N-methyltransferase demonstrated an increased immunopositivity for these cathecolamine-synthesizing enzymes after intense exercise. These results were confirmed by immunoblot accompanied by densitometric analysis.

  16. Formation of Nanoscale Intermetallic Phases in Ni Surface Layer at High Intensity Implantation of Al Ions

    Institute of Scientific and Technical Information of China (English)

    I.A.Bozhko; S.V.Fortuna; I.A.Kurzina; I.B.Stepanov; E.V.Kozlov; Yu.P. Sharkeev

    2004-01-01

    The results of experimental study of nanoscale intermetallic formation in surface layer of a metal target at ion implantation are presented. To increase the thickness of the ion implanted surface layer the high intensive ion implantation is used. Compared with the ordinary ion implantation, the high intensive ion implantation allows a much thicker modified surface layer. Pure polycrystalline nickel was chosen as a target. Nickel samples were irradiated with Al ions on the vacuum-arc ion beam and plasma flow source "Raduga-5". It was shown that at the high intensity ion implantation the fine dispersed particles of Ni3Al, NiAl intermetallic compounds and solid solution Al in Ni are formed in the nickel surface layer of 200 nm and thicker. The formation of phases takes place in complete correspondence with the Ni-Al phase diagram.

  17. The high intensity solar cell - Key to low cost photovoltaic power

    Science.gov (United States)

    Sater, B. L.; Goradia, C.

    1975-01-01

    This paper discusses the problems associated with conventional solar cells at high intensities and presents the design considerations and performance characteristics of the 'high intensity' (HI) solar cell which appears to eliminate the major problems. Test data obtained at greater than 250 AM1 suns gave a peak output power density of 2 W per sq cm at an efficiency exceeding 6% with an unoptimized cell operating at over 100 C. It appears that operation at 1000 AM1 suns at efficiencies greater than 10% is possible. At 1000 AM1 suns and 10% efficiency, the HI cell manufacturing cost is estimated to be $0.25/watt, with multi-megawatt annual production capability already existing within the industrial sector. A high intensity solar system was also analyzed to determine its cost effectiveness and to assess the benefits of further improving HI cell efficiency.

  18. The clinical study on high intensity zone of magnetic resonance imaging using Scolopendrid Aquacupuncture.

    Directory of Open Access Journals (Sweden)

    Jeong-a Lim

    2006-12-01

    Full Text Available Objective : This study was designed to find out the effect of scolopendrid aquacupuncture on low back pain with or without sciatica showing high intensity zone of magnetic resonance imaging. Methods : The 30 patients who had a diagnosis of high intensity zone by lumbar-MRI and admitted to Gwangju oriental medical hospital in wonkwang university from January 2005 to August 2004 were observed. The symptom of inpatients is low back pain with or without sciatica. We treated 30 patients by scolopendrid aquacupuncture besides the general conservative treatment of oriental medicine. Results and Conclusion : The scolopendrid aquacupuncture treatment led to improvement in the pain and symptom of disability as determined by all efficacy measures. After scolopendrid aquacupuncture treatment, there was improvement in VAS, ROM and SLRT. This results suggest that scolopendrid aquacupuncture is good method for treatment of low back pain with or without sciatica showing high intensity zone of magnetic resonance imaging.

  19. Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise

    DEFF Research Database (Denmark)

    Crameri, Regina M; Langberg, Henning; Magnusson, Peter

    2004-01-01

    desmin or dystrophin, were not observed, and hence did not appear to induce the expression of either N-CAM or FA1. We therefore propose that satellite cells can be induced to re-enter the cell growth cycle after a single bout of unaccustomed high intensity exercise. However, a single bout of exercise......No studies to date have reported activation of satellite cells in vivo in human muscle after a single bout of high intensity exercise. In this investigation, eight individuals performed a single bout of high intensity exercise with one leg, the contralateral leg being the control. A significant...... increase in mononuclear cells staining for the neural cell adhesion molecule (N-CAM) and fetal antigen 1 (FA1) were observed within the exercised human vastus lateralis muscle on days 4 and 8 post exercise. In addition, a significant increase in the concentration of the FA1 protein was determined...

  20. Repeated high-intensity exercise modulates Ca(2+) sensitivity of human skeletal muscle fibers

    DEFF Research Database (Denmark)

    Gejl, K D; Hvid, L G; Willis, S J;

    2016-01-01

    The effects of short-term high-intensity exercise on single fiber contractile function in humans are unknown. Therefore, the purposes of this study were: (a) to access the acute effects of repeated high-intensity exercise on human single muscle fiber contractile function; and (b) to examine whether...... the fourth sprint with respect to Ca(2+) sensitivity and maximal Ca(2+) -activated force. To investigate the oxidative effects of exercise on single fiber contractile function, a subset of fibers was incubated with dithiothreitol (DTT) before analysis. Ca(2+) sensitivity was enhanced by exercise in both MHC...... I (17%, P exercise. In conclusion, repeated high-intensity exercise increased Ca(2+) sensitivity in both MHC I and MHC II...

  1. The intensity dependence of surface recombination in high concentration solar cells with charge induced passivation

    Science.gov (United States)

    Gray, J. L.; Schwartz, R. J.; Lundstrom, M. S.; Nasby, R. D.

    High intensity solar cells which are designed to minimize series resistance and shadowing losses, frequently employ an illuminated surface which is relatively far removed from the collecting junctions. This requires that the surface be well passivated to minimize surface recombination. One technique frequently employed to minimize surface recombination is to incorporate a fixed charge in the passivating oxide. This work shows that at sufficiently high intensities the surface recombination can increase dramatically. This results in a reduction in the high intensity collection efficiency. A comparison of the collection efficiency of interdigitated back contact cells and etched multiple vertical junction cells is given which shows that EMVJ cells are less sensitive to this effect than IBC cells.

  2. High-intensity running in English FA Premier League soccer matches

    DEFF Research Database (Denmark)

    Bradley, Paul S.; Sheldon, William; Wooster, Blake

    2009-01-01

    The aims of this study were to (1) determine the activity profiles of a large sample of English FA Premier League soccer players and (2) examine high-intensity running during elite-standard soccer matches for players in various playing positions. Twenty-eight English FA Premier League games were.......01), attackers (2341 m, s=575, P game, high-intensity running distance was approximately 20% less than in the first 15-min period for wide midfielders (467 m, s=104 vs. 589 m, s=134, P ....01) and without ball possession (229 m, s=85 vs. 278 m, s=97, P game. Mean recovery time between very high-intensity running bouts was 72 s (s=28), with a 28% longer recovery time during the last 15 min than the first 15 min of the game (83 s, s=26 vs...

  3. Isolation and rheological properties of tamarind seed polysaccharide from tamarind kernel powder using protease enzyme and high-intensity ultrasound.

    Science.gov (United States)

    Poommarinvarakul, Sukhum; Tattiyakul, Jirarat; Muangnapoh, Chirakarn

    2010-06-01

    The effectiveness of using protease and combinations of protease and high-intensity ultrasound for high-purity, high-yield tamarind seed polysaccharide (TSP) production was investigated. Tamarind kernel powder (TKP) suspension was treated with protease alone at 0.16, 0.48, and 0.80 units/mL and with protease-ultrasound combinations over 3 different orders of sequence (before, simultaneous with, and after protease digestion) using combinations of 0.48 units/mL protease and high-intensity ultrasound at 25% and 50% amplitude for 15 and 30 min. The long protease digestion time could produce high-purity isolated TSP, but the polysaccharide yields were lower. The polysaccharide purity and yield were highly improved, even at a shorter protease digestion time, when the protease treatment was combined with high-intensity ultrasound. The increased amplitude level and sonication time decreased the average molecular weight of the polysaccharide. The rheological properties of the TKP and the isolated TSP, from nondestructive oscillatory measurements, demonstrated that the latter present a viscoelastic solution. The decreasing of protein content resulted in better elasticity of the solution. The power law model could be used to fit the down curve between shear rate and shear stress data. The consistency coefficient (K) increased while the flow behavior index decreased with the increased purity of the polysaccharide as a result of increasing increased digestion time, enzyme concentration, sonication power, and sonication time.

  4. The effects of taurine on vigabatrin, high light intensity and mydriasis induced retinal toxicity in the pigmented rat.

    Science.gov (United States)

    Rasmussen, Allan D; Truchot, Nathalie; Pickersgill, Nigel; Thale, Zia Irene; Rosolen, Serge G; Botteron, Catherine

    2015-01-01

    The overall purpose of this study was to establish a model that may be used for examining the effect of Vigabatrin-induced retinal toxicity in pigmented rats, and subsequently examine the possible effects of taurine on the retinal toxicity. In the first part of the study, pigmented Long Evans rats were subjected to combinations of induced mydriasis, low/high light intensities (40/2000 lx) and oral administration of near-MTD (Maximum Tolerated Dose) doses (200 mg/kg/day) of Vigabatrin for up to 6 weeks. The combination of mydriasis and high light intensity applied to Long Evans rats resulted in retinal damage that was increased by the administration of Vigabatrin. In the second part of the study Long Evans rats were subjected to combinations of induced mydriasis and high/low light intensity (40/2000 lx) while being orally administered low (30 mg/kg/day) or high (200 mg/kg/day) doses of Vigabatrin for up to 6 weeks. In addition, selected groups of animals were administered taurine via the drinking water (20 mg/ml), resulting in systemic taurine concentrations of approximately threefold the endogenous concentration. The combined results of the studies demonstrate that retinal damage can be induced in pigmented animals when combining mydriasis and high light intensity. Retinal damage was functionally evaluated by electroretinography (ERG), then confirmed by histopathology. While depending on mydriasis and high light intensity, administration of Vigabatrin increased the retinal toxicity and resulted in the formation of rosette-like structures in the retina in a dose-related manner. Administration of taurine did not alleviate the Vigabatrin-induced retinal toxicity, as demonstrated either functionally by ERG or morphologically, although systemic concentrations of 3-fold the endogenous levels were reached, and it was thus not possible to demonstrate a protective effect of taurine in these pigmented animals. Copyright © 2014 Elsevier GmbH. All rights reserved.

  5. Modeling Comovements in Trading Intensities to Distinguish Sector and Stock Specific News

    NARCIS (Netherlands)

    Spierdijk, L.; Nijman, T.E.; van Soest, A.H.O.

    2002-01-01

    In this paper we propose a bivariate model for the trading intensities of stocks in a particular industry.The model consists of a univariate duration model for trades in either of the stocks and a probit-specification for which of the two stocks is traded.We apply the model to the trading intensitie

  6. Modeling the dynamics of intense internal waves on the shelf

    Science.gov (United States)

    Talipova, T. G.; Pelinovsky, E. N.; Kurkin, A. A.; Kurkina, O. E.

    2014-11-01

    The transformation of the internal wave packet during its propagation over the shelf of Portugal was studied in the international experiment EU MAST II MORENA in 1994. This paper presents the results of modeling of the dynamics of this packet under hydrological conditions along the pathway of its propagation. The modeling was performed on the basis of the generalized Gardner-Ostrovskii equation, including inhomogeneous hydrological conditions, rotation of the Earth, and dissipation in the bottom boundary layer. We also discuss the results of the comparison of the observed and simulated forms and phases of individual waves in a packet at reference points.

  7. Localized Ablation of Thyroid Tissue by High-Intensity Focused Ultrasound: an Alternative to Surgery?

    Science.gov (United States)

    Esnault, Olivier; Franc, Brigitte; Chapelon, Jean-Yves; Lacoste, Francois

    2006-05-01

    PURPOSE: The aim of this study was to evaluate the feasibility of using a High-intensity focused ultrasound (HIFU) device to obtain a localised destruction of the thyroid with no damage to adjacent tissues. MATERIALS AND METHODS: The ewe model was used because its thyroid gland is easily accessible with ultrasound. The animals were anaesthetised with 10 mg / kg IV injection of Penthothal. The HIFU pulses were generated by a 3-MHz spherical transducer under ultrasound guidance. Macroscopic and microscopic tissue lesions were identified after formalin fixation of the anterior part of the ewe's neck. RESULTS: After determining the optimal instrument settings to obtain localized thyroid ablation, the repeatability of the method was evaluated using a HIFU prototype designed specifically for human use: in 13 ewes (26 treated lobes), an average of 20 (range: 14-27) ultrasound pulses (pulse duration: 3 s) per lobe covering a mean volume of 0.5 cm3 (range: 0.3-0.7 cm3) were delivered. The ewes were sacrificed 2-5 weeks after treatment delivery. No damage to the nerves, trachea, esophagus or muscle was observed. Only 3 ewes suffered superficial skin burns. The desired thyroid lesions were obtained in 25/26 treated lobes, as demonstrated by fibrotic tissues, which replaced necrotic areas. CONCLUSION: These results obtained in the ewe model show that thyroid lesions of defined volume can be induced safely and suggest that the HIFU device is now ready for human trials.

  8. Stimulated recombination of antiproton and positron with ultra-short ultra-high intensity laser pulse

    CERN Document Server

    Ryabinina, M V

    2003-01-01

    Ionization of hydrogen atom in the field of high-intense ultra-short femto-second laser pulse recently became the subject of comprehensive theoretical approaches. On the other hand, there exists experimental evidence that short electric pulses can effectively stimulate electron-proton (as well as antiproton-positron) recombination to high-level (Rydberg) state. In this paper we present the results of the theoretical estimations of antiproton-positron recombination cross-section in cold mixed plasmas in traps in the conditions of ATHENA/ATRAP experiments in CERN under the action of sub-fs laser pulse with TW intensity. (2 refs).

  9. Threshold Stress Intensity of Hydrogen-Induced Cracking and Stress Corrosion Cracking of High Strength Steel

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The threshold stress intensity of stress corrosion cracking (SCC) for 40CrMo steel in 3.5 % NaCl solution decreased exponentially with the increase of yield strength. The threshold stress intensity of hydrogen-induced cracking during dynamical charging for 40CrMo steel decreased linearly with the logarithm of the concentration of diffusible hydrogen. This equation was also applicable to SCC of high strength steel in aqueous solution. The critical hydrogen enrichment concentration necessary for SCC of high strength steel in water decreased exponentially with the increase of yield strength. Based on the results, the relationship between KISCC and σys could be deduced.

  10. Design concept of radiation control system for the high intensity proton accelerator facility

    Energy Technology Data Exchange (ETDEWEB)

    Miyamoto, Yukihiro; Ikeno, Koichi; Akiyama, Shigenori; Harada, Yasunori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2002-11-01

    Description is given for the characteristic radiation environment for the High Intensity Proton Accelerator Facility and the design concept of the radiation control system of it. The facility is a large scale accelerator complex consisting of high energy proton accelerators carrying the highest beam intensity in the world and the related experimental facilities and therefore provides various issues relevant to the radiation environment. The present report describes the specifications for the radiation control system for the facility, determined in consideration of these characteristics. (author)

  11. Rapid response of soil fungal communities to low and high intensity fire

    Science.gov (United States)

    Smith, Jane E.; Cowan, Ariel D.; Reazin, Chris; Jumpponen, Ari

    2016-04-01

    Contemporary fires have created high-severity burn areas exceeding historical distributions in forests in the western United States. Until recently, the response of soil ecosystems to high intensity burns has been largely unknown. In complementary studies, we investigated the environmental effect of extreme soil heating, such that occurs with the complete combustion of large down wood during wildfires, on soil fungi and nutrients. We used TRFLP and next generation sequencing (Illumina MiSeq) to investigate the fungal communities. During the burning of large down wood, temperatures lethal to fungi were detected at 0-cm, 5-cm, and 10-cm depths in soils compared to 0-cm depth in soils receiving low intensity broadcast burns. We compared the soil fungal diversity in ten high intensity burned plots paired with adjacent low intensity burned plots before and one week after at 0-10 cm soil depth. Nonmetric Multidimensional Scaling (NMS) ordinations and analyses of taxon frequencies reveal a substantial community turnover and corresponding near complete replacement of the dominant basidiomycetes by ascomycetes in high intensity burns. These coarse-level taxonomic responses were primarily attributable to a few fire-responsive (phoenicoid) fungi, particularly Pyronema sp. and Morchella sp., whose frequencies increased more than 100-fold following high intensity burns. Pinus ponderosa seedlings planted one week post-burn were harvested after four months for EMF root tip analysis. We found: a) greater differences in soil properties and nutrients in high intensity burned soils compared to low intensity burned and unburned soils; b) no differences in EMF richness and diversity; and c) weak differences in community composition based on relative abundance between unburned and either burn treatments. These results confirm the combustion of large downed wood can alter the soil environment directly beneath it. However, an EMF community similar to low burned soils recolonized high

  12. [Metabolic response to high intensity exercise training in sedentary hyperglycemic and hypercholesterolemic women].

    Science.gov (United States)

    Alvarez L, Cristian; Ramírez-Campillo, Rodrigo; Flores O, Marcelo; Henríquez-Olguín, Carlos; Campos J, Christian; Carrasco, Vanesa; Martínez S, Cristian; Celis-Morales, Carlos

    2013-10-01

    High intensity training could be an effective way of improving health on individuals at high metabolic risk. To investigate the effects of a high intensity training intervention on metabolic-related markers in sedentary women at high metabolic risk. Forty six sedentary women with a body mass index (BMI) over 25 kg/m² were assigned to four groups, according to their metabolic profile; hyperglycemia (H, n = 12), hyperglycemia/hypercholesterolemia (HH, n = 13), normoglycemia (N, n = 10) and normoglycemia/hypercholesterolemia (NH, n = 11). For 12 weeks and five days per week, subjects performed seven intervals of high intensity training (20 to 30 seconds) during a training session of 20 minutes. Anthropometric (body weight, body mass index (BMI), waist circumference) and metabolic variables (glucose, total cholesterol, LDL, HDL and TG) were measured at baseline, at 6 and 12 weeks of intervention. BMI and waist circumference decreased significantly after 12 weeks of intervention. Similarly, glucose decreased significantly after 12 weeks of intervention in all groups. The reduction was of higher magnitude in those groups with hyperglycemia (H = -16%, HH = -22%, N = -7,5%, NH = -9,6%). However, lipid profile (TG, total cholesterol, LDL and HDL) improved significantly only in the hypercholesterolemic groups. Physical activity programs incorporating high intensity training can improve glucose and lipid profile in women with metabolic disorders. Moreover, this benefit is greatest in those individuals with highest metabolic burden.

  13. Simulation of the Beam Dump for a High Intensity Electron Gun

    CERN Document Server

    Doebert, S; Lefevre, T; Pepitone, K

    2014-01-01

    The CLIC Drive Beam is a high-intensity pulsed electron beam. A test facility for the Drive Beam electron gun will soon be commissioned at CERN. In this contribution we outline the design of a beam dump / Faraday cup capable of resisting the beam’s thermal load. The test facility will operate initially up to 140 keV. At such low energies, the electrons are absorbed very close to the surface of the dump, leading to a large energy deposition density in this thin layer. In order not to damage the dump, the beam must be spread over a large surface. For this reason, a small-angled cone has been chosen. Simulations using Geant4 have been performed to estimate the distribution of energy deposition in the dump. The heat transport both within the electron pulse and between pulses has been modelled using finite element methods to check the resistance of the dump at high repetition rates. In addition, the possibility of using a moveable dump to measure the beam profile and emittance is discussed.

  14. Personalized metabolomics for predicting glucose tolerance changes in sedentary women after high-intensity interval training.

    Science.gov (United States)

    Kuehnbaum, Naomi L; Gillen, Jenna B; Gibala, Martin J; Britz-McKibbin, Philip

    2014-08-28

    High-intensity interval training (HIIT) offers a practical approach for enhancing cardiorespiratory fitness, however its role in improving glucose regulation among sedentary yet normoglycemic women remains unclear. Herein, multi-segment injection capillary electrophoresis-mass spectrometry is used as a high-throughput platform in metabolomics to assess dynamic responses of overweight/obese women (BMI > 25, n = 11) to standardized oral glucose tolerance tests (OGTTs) performed before and after a 6-week HIIT intervention. Various statistical methods were used to classify plasma metabolic signatures associated with post-prandial glucose and/or training status when using a repeated measures/cross-over study design. Branched-chain/aromatic amino acids and other intermediates of urea cycle and carnitine metabolism decreased over time in plasma after oral glucose loading. Adaptive exercise-induced changes to plasma thiol redox and orthinine status were measured for trained subjects while at rest in a fasting state. A multi-linear regression model was developed to predict changes in glucose tolerance based on a panel of plasma metabolites measured for naïve subjects in their untrained state. Since treatment outcomes to physical activity are variable between-subjects, prognostic markers offer a novel approach to screen for potential negative responders while designing lifestyle modifications that maximize the salutary benefits of exercise for diabetes prevention on an individual level.

  15. High-intensity femtosecond laser absorption by rare-gas clusters

    Institute of Scientific and Technical Information of China (English)

    李邵辉; 王成; 刘建胜; 王向欣; 朱频频; 李儒新; 倪国权; 徐至展

    2003-01-01

    The energy absorption efficiency of high-intensity (~ 1016W/cm2) femtosecond laser pulses in a dense jet of large rare-gas clusters has been measured. Experimental results show that the energy absorption efficiency is strongly dependent on the cluster size and can be higher than 90%. The measurement of the ion energy indicates that the average ion energies of argon and xenon can be as high as 90 and 100keV, respectively. The dependence of the average energy of the ions on the cluster size is also measured. At comparatively low gas backing pressure, the average ion energies of argon and xenon increase with increasing gas backing pressure. The average ion energy of argon becomes saturated gradually with further increase of the gas backing pressure. For xenon, the average ion energy drops a little after the gas backing pressure exceeds 9 bar (3.2×105 atoms/cluster). The result showing the existence of a maximum average ion energy has been interpreted within the framework of the microplasma sphere model.

  16. Preliminary safety analysis of high-intensity interval training (HIIT) in persons with chronic stroke.

    Science.gov (United States)

    Carl, Daniel L; Boyne, Pierce; Rockwell, Bradley; Gerson, Myron; Khoury, Jane; Kissela, Brett; Dunning, Kari

    2017-03-01

    The purpose of this study was to assess safety via electrocardiographic (ECG), blood pressure (BP), heart rate (HR), and orthopedic responses to 3 different high-intensity interval training (HIIT) protocols in persons with stroke. Eighteen participants (10 male; 61.9 + 8.3 years of age; 5.8 + 4.2 years poststroke) completed a symptom-limited graded exercise test (GXT) with ECG monitoring to screen for eligibility and determine HR peak. The 3 HIIT protocols involved repeated 30 s bursts of treadmill walking at maximum speed alternated with rest periods of 30 s (P30), 1 min (P60), or 2 min (P120). Sessions were performed in random order and included 5 min warm up, 20 min HIIT, and 5 min cool down. Variables measured included ECG activity, BP, HR, signs and symptoms of cardiovascular intolerance, and orthopedic concerns. Generalized linear mixed models and Tukey-Kramer adjustment were used to compare protocols using p HIIT session. HIIT elicited HRs in excess of 88% of measured HRpeak including 6 (P30), 8 (P60), and 2 (P120) participants eliciting a HR response above their GXT HRpeak. Both maximum BP and HR were significantly higher in P30 and P60 relative to P120. Preliminary data indicate that persons with chronic stroke who have been prescreened with an ECG stress test, a symptom-limited GXT, and a harness for fall protection may safely participate in HIIT, generating substantially higher HRs than what is seen in traditional moderate intensity training.

  17. VO2max trainability and high intensity interval training in humans: a meta-analysis.

    Science.gov (United States)

    Bacon, Andrew P; Carter, Rickey E; Ogle, Eric A; Joyner, Michael J

    2013-01-01

    Endurance exercise training studies frequently show modest changes in VO2max with training and very limited responses in some subjects. By contrast, studies using interval training (IT) or combined IT and continuous training (CT) have reported mean increases in VO2max of up to ~1.0 L · min(-1). This raises questions about the role of exercise intensity and the trainability of VO2max. To address this topic we analyzed IT and IT/CT studies published in English from 1965-2012. Inclusion criteria were: 1)≥ 3 healthy sedentary/recreationally active humans training duration 6-13 weeks, 3) ≥ 3 days/week, 4) ≥ 10 minutes of high intensity work, 5) ≥ 1:1 work/rest ratio, and 6) results reported as mean ± SD or SE, ranges of change, or individual data. Due to heterogeneity (I(2) value of 70), statistical synthesis of the data used a random effects model. The summary statistic of interest was the change in VO2max. A total of 334 subjects (120 women) from 37 studies were identified. Participants were grouped into 40 distinct training groups, so the unit of analysis was 40 rather than 37. An increase in VO2max of 0.51 L · min(-1) (95% CI: 0.43 to 0.60 L · min(-1)) was observed. A subset of 9 studies, with 72 subjects, that featured longer intervals showed even larger (~0.8-0.9 L · min(-1)) changes in VO2max with evidence of a marked response in all subjects. These results suggest that ideas about trainability and VO2max should be further evaluated with standardized IT or IT/CT training programs.

  18. VO2max trainability and high intensity interval training in humans: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Andrew P Bacon

    Full Text Available Endurance exercise training studies frequently show modest changes in VO2max with training and very limited responses in some subjects. By contrast, studies using interval training (IT or combined IT and continuous training (CT have reported mean increases in VO2max of up to ~1.0 L · min(-1. This raises questions about the role of exercise intensity and the trainability of VO2max. To address this topic we analyzed IT and IT/CT studies published in English from 1965-2012. Inclusion criteria were: 1≥ 3 healthy sedentary/recreationally active humans <45 yrs old, 2 training duration 6-13 weeks, 3 ≥ 3 days/week, 4 ≥ 10 minutes of high intensity work, 5 ≥ 1:1 work/rest ratio, and 6 results reported as mean ± SD or SE, ranges of change, or individual data. Due to heterogeneity (I(2 value of 70, statistical synthesis of the data used a random effects model. The summary statistic of interest was the change in VO2max. A total of 334 subjects (120 women from 37 studies were identified. Participants were grouped into 40 distinct training groups, so the unit of analysis was 40 rather than 37. An increase in VO2max of 0.51 L · min(-1 (95% CI: 0.43 to 0.60 L · min(-1 was observed. A subset of 9 studies, with 72 subjects, that featured longer intervals showed even larger (~0.8-0.9 L · min(-1 changes in VO2max with evidence of a marked response in all subjects. These results suggest that ideas about trainability and VO2max should be further evaluated with standardized IT or IT/CT training programs.

  19. High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease.

    Science.gov (United States)

    Tucker, Patrick S; Briskey, David R; Scanlan, Aaron T; Coombes, Jeff S; Dalbo, Vincent J

    2015-12-01

    Increased levels of oxidative stress and inflammation have been linked to the progression of chronic kidney disease. To reduce oxidative stress and inflammation related to chronic kidney disease, chronic aerobic exercise is often recommended. Data suggests high intensity interval training may be more beneficial than traditional aerobic exercise. However, appraisals of differing modes of exercise, along with explanations of mechanisms responsible for observed effects, are lacking. This study assessed effects of eight weeks of high intensity interval training (85% VO2max), versus low intensity exercise (45-50% VO2max) and sedentary behaviour, in an animal model of early-stage chronic kidney disease. We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzyme activity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation. Compared to sedentary behaviour, high intensity interval training resulted in increased mRNA expression of Sod1 (p=0.01) and Cat (pinflammation.

  20. Preliminary study of the behavioral and biological effects of high intensity 60 HZ electric fields. Interim technical progress report No. 4

    Energy Technology Data Exchange (ETDEWEB)

    Feldstone, C.; Spiegel, R.J.; Winters, W.; Polonis, J.J.

    1980-03-01

    Progress is reported in studies of the effects of high intensity 60 Hz electric fields on baboon behavior - both individual performance (operant conditioning) and natural (social) behavior. The result of the study should be either a clear indication of the electric field intensity which produces deleterious effects in the baboon or an indication that the highest field intensity of practical interest (analogous to the highest intensity that can be encountered by man under power lines) produces no deleterious effects. The generalization of results to man will be futher aided by the development of models relating the physical effects of electric fields on man to the physical effects on the baboon. (LCL)

  1. Predictive model for SEPSIS in the intensive care unit.

    Directory of Open Access Journals (Sweden)

    Lavoisier Morais de Medeiros

    2016-07-01

    Full Text Available This study aimed to provide a probabilistic decision model for sepsis, early diagnosis. The data contained in the medical records of 100 individuals admitted to a general ICU in a public hospital in the inland of the State of Paraiba were analyzed, in the period from March to September, 2011. The studied variables were: age, gender, initial diagnosis, minimum and maximum axillary temperature, heart and breathing rate, oxygen and carbon dioxide partial pressure, lactate serum levels, potassium, sodium, total count of leukocytes, bands and segs., among others. The binary logistic regression were used to determine the prediction model, and data were analyzed by SPSS software, version 19.0. 63% of the subjects were male, with a 62.5 year average age. as explanatory variables the following were considered: minimum axillary temperature, maximum axillary temperature, carbon dioxide partial pressure, lactate, white blood cell count and number of bands. Through ROC curve we identified the ideal cut-off point for classifying the subjects with regard to the presence or absence of disease, which has contributed to formulating the decision-making rule for sepsis early diagnosis. The concordance degree were compared between blood culture result regarded as gold standard for infection diagnosis and the model submitted in the study using Kappa coefficient, obtaining a 0.93 concordance percentage, regarded as outstanding. It was demonstrated being possible to carry out sepsis early detection adopting statistical models as the submitted one, however, new studies with populations from different ICUs must be performed in order to provide a better casuistry, making the found results reproducible in different clinical situations.

  2. Modelling cosmic ray intensities along the Ulysses trajectory

    Directory of Open Access Journals (Sweden)

    D. C. Ndiitwani

    2005-03-01

    Full Text Available Time dependent cosmic ray modulation in the inner heliosphere is studied by comparing results from a 2-D, time-dependent cosmic ray transport model with Ulysses observations. A compound approach, which combines the effects of the global changes in the heliospheric magnetic field magnitude with drifts to establish a realistic time-dependence, in the diffusion and drift coefficients, are used. We show that this model results in realistic cosmic ray modulation from the Ulysses launch (1990 until recently (2004 when compared to 2.5-GV electron and proton and 1.2-GV electron and Helium observations from this spacecraft. This approach is also applied to compute radial gradients present in 2.5-GV cosmic ray electron and protons in the inner heliosphere. The observed latitude dependence for both positive and negative charged particles during both the fast latitude scan periods, corresponding to different solar activity conditions, could also be realistically computed. For this an additional reduction in particle drifts (compared to diffusion toward solar maximum is needed. This results in a realistic charge-sign dependent modulation at solar maximum and the model is also applied to predict charge-sign dependent modulation up to the next expected solar minimum.

  3. A numerical investigation of the performance of sound intensity probes at high frequencies

    DEFF Research Database (Denmark)

    Cutanda, Vicente; Juhl, Peter Møller; Jacobsen, Finn

    1996-01-01

    The influence of diffraction on the performance of sound intensity probes has been examined using a boundary element model of an axisymmetric 'two-microphone' probe with the microphones in the usual 'face-to-face' arrangement. On the basis of calculations for a variety of sound field conditions a...

  4. Physics of Neutralization of Intense High-Energy Ion Beam Pulses by Electrons

    Energy Technology Data Exchange (ETDEWEB)

    Kaganovich, I. D.; Davidson, R. C.; Dorf, M. A.; Startsev, E. A.; Sefkow, A. B.; Lee, E. P.; Friedman, A.

    2010-04-28

    Neutralization and focusing of intense charged particle beam pulses by electrons forms the basis for a wide range of applications to high energy accelerators and colliders, heavy ion fusion, and astrophysics. For example, for ballistic propagation of intense ion beam pulses, background plasma can be used to effectively neutralize the beam charge and current, so that the self-electric and self- magnetic fields do not affect the ballistic propagation of the beam. From the practical perspective of designing advanced plasma sources for beam neutralization, a robust theory should be able to predict the self-electric and self-magnetic fields during beam propagation through the background plasma. The major scaling relations for the self-electric and self-magnetic fields of intense ion charge bunches propagating through background plasma have been determined taking into account the effects of transients during beam entry into the plasma, the excitation of collective plasma waves, the effects of gas ionization, finite electron temperature, and applied solenoidal and dipole magnetic fields. Accounting for plasma production by gas ionization yields a larger self-magnetic field of the ion beam compared to the case without ionization, and a wake of current density and self-magnetic field perturbations is generated behind the beam pulse. A solenoidal magnetic field can be applied for controlling the beam propagation. Making use of theoretical models and advanced numerical simulations, it is shown that even a small applied magnetic field of about 100G can strongly affect the beam neutralization. It has also been demonstrated that in the presence of an applied magnetic field the ion beam pulse can excite large-amplitude whistler waves, thereby producing a complex structure of self-electric and self-magnetic fields. The presence of an applied solenoidal magnetic field may also cause a strong enhancement of the radial self-electric field of the beam pulse propagating through the

  5. Rainfall intensity characteristics at coastal and high altitude stations in Kerala

    Indian Academy of Sciences (India)

    V Sasi Kumar; S Sampath; P V S S K Vinayak; R Harikumar

    2007-10-01

    Rainfall intensities measured at a few stations in Kerala during 2001 –2005 using a disdrometer were found to be in reasonable agreement with the total rainfall measured using a manual rain gauge. The temporal distributions of rainfall intensity at different places and during different months show that rainfall is of low intensity (> 10 mm/hr),65%to 90%of the time.This could be an indication of the relative prevalence of stratiform and cumuliform clouds.Rainfall was of intensity > 5 mm/hr for more than 95%of the time in Kochi in July 2002,which was a month seriously deficient in rainfall,indicating that the deficiency was probably due to the relative absence of cumuliform clouds.Cumulative distribution graphs are also plotted and fitted with the Weibull distribution.The fit parameters do not appear to have any consistent pattern. The higher intensities also contributed signi ficantly to total rainfall most of the time,except in Munnar (a hill station). In this analysis also,the rainfall in Kochi in July 2002 was found to have less presence of high intensities. This supports the hypothesis that the rainfall de ficiency was probably caused by the absence of conditions that favoured the formation of cumuliform clouds.

  6. Novel high-energy physics studies using intense lasers and plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Leemans, Wim P. [Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bulanov, Stepan [Univ. of California, Berkeley, CA (United States); Esarey, Eric [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schroeder, Carl [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-06-29

    In the framework of the project “Novel high-energy physics studies using intense lasers and plasmas” we conducted the study of ion acceleration and “flying mirrors” with high intensity lasers in order to develop sources of ion beams and high frequency radiation for different applications. Since some schemes of laser ion acceleration are also considered a good source of “flying mirrors”, we proposed to investigate the mechanisms of “mirror” formation. As a result we were able to study the laser ion acceleration from thin foils and near critical density targets. We identified several fundamental factors limiting the acceleration in the RPA regime and proposed the target design to compensate these limitations. In the case of near critical density targets, we developed a concept for the laser driven ion source for the hadron therapy. Also we studied the mechanism of “flying mirror” generation during the intense laser interaction with thin solid density targets. As for the laser-based positron creation and capture we initially proposed to study different regimes of positron beam generation and positron beam cooling. Since the for some of these schemes a good quality electron beam is required, we studied the generation of ultra-low emittance electron beams. In order to understand the fundamental physics of high energy electron beam interaction with high intensity laser pulses, which may affect the efficient generation of positron beams, we studied the radiation reaction effects.

  7. Beam Dynamics Observations of the 2015 High Intensity Scrubbing Runs at the Cern Sps

    CERN Document Server

    Bartosik, Hannes; Li, Kevin; Mether, Lotta; Romano, Annalisa; Rumolo, Giovanni; Schenk, Michael

    2016-01-01

    Beam quality degradation caused by e-cloud effects has been identified as one of the main performance limitations for high intensity LHC beams with 25 ns bunch spacing in the SPS. In view of the beam parameters targeted with the LHC injectors upgrade (LIU) project, about two weeks of SPS machine time in 2015 were devoted to dedicated scrubbing runs with high intensity LHC 25 ns and dedicated 'doublet' beams in order to study the achievable reduction of e-cloud effects and quantify the consequent beam performance improvements. This paper describes the main observations concerning the coherent instabilities and beam dynamics limitations encountered as well as a detailed characterisation of the performance reach with the highest beam intensity presently available from the pre-injectors.

  8. Oral versus Nasal Breathing during Moderate to High Intensity Submaximal Aerobic Exercise

    Directory of Open Access Journals (Sweden)

    Chase O. LaComb

    2017-01-01

    Full Text Available Introduction: When comparing oral breathing versus nasal breathing, a greater volume of air can be transported through the oral passageway but nasal breathing may also have benefits at submaximal exercise intensities. Purpose: The purpose of this study was to determine breathing efficiency during increasing levels of submaximal aerobic exercise. Methods: Nineteen individuals (males N=9, females N=10 completed a test for maximal oxygen consumption (VO2max and on separate days 4-min treadmill runs at increasing submaximal intensities (50%, 65%, and 80% of VO2max under conditions of oral breathing or nasal breathing. Respiratory (respiration rate [RR], pulmonary ventilation [VE], metabolic (oxygen consumption [VO2], carbon dioxide production [VCO2] and efficiency measures (ventilatory equivalents for oxygen [Veq×O2-1] and carbon dioxide [Veq×CO2-1] were obtained. Data were analyzed utilizing a 2 (sex x 2 (condition x3 (intensity repeated measures ANOVA with significance accepted at p≤0.05. Results: Significant interactions existed between breathing mode and intensity such that oral breathing resulted in greater RR, VE, VO2, and VCO2 at all three submaximal intensities (p<.05.  Veq×O2-1 and Veq×CO2-1 presented findings that nasal breathing was more efficient than oral breathing during the 65% and 80% VO2max intensities (p<0.05. Conclusion: Based on this analysis, oral breathing provides greater respiratory and metabolic volumes during moderate and moderate-to-high submaximal exercise intensities, but may not translate to greater respiratory efficiency. However when all variables are considered together, it is likely that oral breathing represents the more efficient mode, particularly at higher exercise intensities.

  9. Multi-instrument observations and numerical modeling of intense ion upflows during stormtime polar cap expansion

    Science.gov (United States)

    Zou, S.; Ozturk, D. S.; Ridley, A. J.; Jia, X.; Nicolls, M. J.; Coster, A. J.; Thomas, E. G.; Ruohoniemi, J. M.

    2016-12-01

    The Earth's ionosphere plays an important role in supplying plasma into the magnetosphere through ion upflow/outflow, particularly during periods of strong solar wind driving. An intense ion upflow flux event during the June 1, 2013 geomagnetic storm has been studied using observations from multiple instruments, including Poker Flat incoherent scatter radar (PFISR) and GPS total electron content (TEC), as well as numerical simulations. After the IMF southward turning, the open-closed field line boundary (OCB) and convection cells in the high latitude Northern hemisphere, as observed by the Defense Meteorological Satellite Program (DMSP) satellites and the Super Dual Auroral Radar Network (SuperDARN) radars, expanded equatorward rapidly. When the cusp moved into the PFISR field-of-view, divergent ion fluxes were observed by the field-aligned beam of PFISR with intense ion upflow fluxes reaching 1.9 x1014 m-2s-1 at 600 km altitude. Both ion and electron temperatures increased significantly within the ion upflow and thus this upflow event was classified as Type-2 upflow. We discuss possible contributing factors for the formation of such intense ion upflow fluxes, including preconditioning by storm-enhanced density (SED) and temperature dependent chemistry. The global ionosphere thermosphere model (GITM) has been employed to quantitatively study the formation mechanisms of the upflows. During this event, the OCB and cusp were detected by DMSP between 15-16 MLTs, unusually duskward. Results from a global MHD simulation using the Space Weather Modeling Framework (SWMF) have been used to provide a global context for this event. The global simulation suggests that due to the very low solar wind Mach number ( 4), magnetopause reconnection occurred across a wide range of local times extending into the dusk sector where DMSP observed the cusp.

  10. Future Perspectives in Nuclear Structure: From high intensity stable to radioactive nuclear beams

    Science.gov (United States)

    de Angelis, Giacomo

    2005-04-01

    Future perspectives in nuclear structure rely on radioactive nuclear beams as well as on high intensity beams of stable ions. Especially for neutron rich nuclei, deep-inelastic and multi-nucleon transfer reactions can be used to populate yrast and non yrast states. Particularly powerful is here the combination of large acceptance spectrometers with highly segmented γ-detector arrays. Such devices, eventually complemented by large cov- erage particle detectors, can provide the necessary channel selectivity to identify very rare signals. An example is the CLARA γ-ray detector array coupled with the PRISMA spectrometer at the Legnaro National Laboratories (LNL). The physics aims achievable with this setup will complement studies performed with current radioactive beam (RIB) facilities. With such set-up we have recently investigated the stability of the N=50 shell closure when moving towards more exotic systems. Here the comparison of the experi- mental data with shell model calculations seems to indicate a persistence of the N=50 shell gap down to Z=32. Future perspectives at LNL are based on an increase in in- tensity as well as on the availability of heavy ion species. Beams like 136Xe or 208Pb, which will be provided by the new PIAVE injector, can be used to drive the multinucleon flux toward the more exotic regions. Moreover a new ISOL facility (SPES) dedicated to the production and acceleration of radioactive neutron rich species is now under develop- ment at LNL. It will be based on an high intensity proton and deuteron LINAC. Induced fission fragments will be ionized and then accelerated using the presently existing super- conductive LINAC (ALPI). Among the new instrumentation the concept of γ-ray tracking has been recently introduced in nuclear spectroscopy. Detectors based on γ-ray tracking have position resolution capabilities with excellent performances both in efficiency and in achievable Doppler correction. A new γ-ray detector array (AGATA) based on

  11. Documenting PyroCb Development on High-Intensity Boreal Fires: Implications for the Arctic Atmosphere

    Science.gov (United States)

    Stocks, B. J.; Fromm, M. D.; Servranckx, R.; Lindsey, D.

    2007-12-01

    The recent confirmation that smoke from high-intensity boreal forest fires can reach the Upper Troposphere/Lower Stratosphere (UTLS) through pyroconvection and be transported long distances has raised concern over the wider-scale environmental impact of boreal fire smoke. This concern is further elevated as climate change projections indicate a significant increase in the frequency and severity of boreal forest fires over the next century. Smoke in the UTLS is frequently transported to the Arctic and may have important implications for the radiative energy budget in the polar region. Soot deposition from fires may lead to enhanced melting of sea ice and glaciers, and the chemical impact of fire emissions at high altitudes is largely unknown. This knowledge gap will be addressed during the International Polar Year (IPY), as boreal fire emissions will be tracked and documented in detail through aerial, satellite and ground-based measurements, as a key component of the POLARCAT (Polar Study using Aircraft, Remote Sensing, Surface Measurements and Models, of Climate, Chemistry, Aerosols, and Transport) and ARCTAS (Arctic Research of the Composition of the Troposphere from Aircraft and Satellites) projects to be conducted in 2008. A large fire in the Canadian Northwest Territories burned throughout the month of June 2007, in a remote region where forest fires are not actively suppressed, eventually reaching 90,000 hectares in size. This fire was monitored for blowup one week in advance; it erupted into pyroconvection on June 25, 2007. We present an analysis of this event combining satellite data with ground-based measurements to document the development and impact of this classic pyroCb event. Under extreme fire danger conditions, the fire burned close to 20,000 hectares on that day. Fire behavior was consistent with predictions using the Canadian Fire Behavior Prediction System, with the fire spreading at 2.7 km/hr, consuming 33,000 kg of fuel hourly, generating an

  12. High-intensity interval training (HIIT for patients with chronic diseases

    Directory of Open Access Journals (Sweden)

    Leanna M. Ross

    2016-06-01

    Full Text Available Exercise training provides physiological benefits for both improving athletic performance and maintaining good health. Different exercise training modalities and strategies exist. Two common exercise strategies are high-intensity interval training (HIIT and moderate-intensity continuous exercise training (MCT. HIIT was first used early in the 20th century and popularized later that century for improving performance of Olympic athletes. The primary premise underlying HIIT is that, compared to energy expenditure-matched MCT, a greater amount of work is performed at a higher intensity during a single exercise session which is achieved by alternating high-intensity exercise intervals with low-intensity exercise or rest intervals. Emerging research suggests that this same training method can provide beneficial effects for patients with a chronic disease and should be included in the comprehensive medical management plan. Accordingly, a major consideration in developing an individual exercise prescription for a patient with a chronic disease is the selection of an appropriate exercise strategy. In order to maximize exercise training benefits, this strategy should be tailored to the individual's need. The focus of this paper is to provide a brief summary of the current literature regarding the use of HIIT to enhance the functional capacity of individuals with cardiovascular, pulmonary, and diabetes diseases.

  13. The effect of high and low exercise intensity periods on a simple memory recognition test

    Institute of Scientific and Technical Information of China (English)

    Ben Rattray; Disa J. Smee

    2016-01-01

    Purpose: The purpose of this study was to investigate the effect of variable intensities on a simple memory recognition task during exercise. Methods: Twenty active participants took part in initial testing, a familiarization trial and then four 60 min cycling interventions in a randomized order. Interventions consisted of no exercise (control), constant exercise at 90%ventilatory threshold (constant) and 2 trials that initially mimicked the constant trial, but then included periods of high (∼90%VO2peak) and low intensities (∼50%VO2peak). Cardiorespiratory measures and capillary blood samples were taken throughout. A short tablet-based cognitive task was completed prior to and during (50 and 55 min into exercise) each intervention. Results: The exercise conditions facilitated response time (p=0.009), although the extent of this effect was not as strong in the variable exercise conditions (p = 0.011–0.089). High intensity exercise periods resulted in some cognitive regression back towards control trial performance. Elevations in cardiorespiratory measures and periods of hypocapnia could not explain changes in cognitive performance. Conclusion: Changes in cognitive performance with variations in exercise intensity are likely to have implications for sport and occupational settings. The timing of cognitive tests to exercise intensity changes as well as use of short cognitive assessments will be important for future work.

  14. High-intensity interval training (HIIT) for patients with chronic diseases

    Institute of Scientific and Technical Information of China (English)

    Leanna M. Ross; Ryan R. Porter; J. Larry Durstine

    2016-01-01

    Exercise training provides physiological benefits for both improving athletic performance and maintaining good health. Different exercise training modalities and strategies exist. Two common exercise strategies are high-intensity interval training (HIIT) and moderate-intensity continuous exercise training (MCT). HIIT was first used early in the 20th century and popularized later that century for improving performance of Olympic athletes. The primary premise underlying HIIT is that, compared to energy expenditure-matched MCT, a greater amount of work is performed at a higher intensity during a single exercise session which is achieved by alternating high-intensity exercise intervals with low-intensity exercise or rest intervals. Emerging research suggests that this same training method can provide beneficial effects for patients with a chronic disease and should be included in the comprehensive medical management plan. Accordingly, a major consideration in developing an individual exercise prescription for a patient with a chronic disease is the selection of an appropriate exercise strategy. In order to maximize exercise training benefits, this strategy should be tailored to the individual’s need. The focus of this paper is to provide a brief summary of the current literature regarding the use of HIIT to enhance the functional capacity of individuals with cardiovascular, pulmonary, and diabetes diseases.

  15. High Intensity Interval Training in Handcycling : The Effects of a 7 Week Training Intervention in Able-bodied Men

    NARCIS (Netherlands)

    Schoenmakers, Patrick; Reed, Kate; Van Der Woude, Luc; Hettinga, Florentina J.

    2016-01-01

    INTRODUCTION: In lower body endurance training, quantities of both moderate intensity continuous training (MICT) and high intensity interval training (HIIT) can lead to an improved physiological capacity and performance. Limited research is available regarding the endurance and muscular capacity of

  16. Effects of high-intensity interval versus mild-intensity endurance training on metabolic phenotype and corticosterone response in rats fed a high-fat or control diet.

    Science.gov (United States)

    Shen, Youqing; Huang, Guoyuan; McCormick, Bryan P; Song, Tao; Xu, Xiangfeng

    2017-01-01

    The aim of the present study was to compare the effects of high-intensity interval training (HI) to mild-intensity endurance training (ME), combined with a high-fat diet (HFD) or control diet (CD) on metabolic phenotype and corticosterone levels in rats. Fifty-three rats were randomized to 6 groups according to diet and training regimen as follows: CD and sedentary (CS, n = 11), CD and ME (CME, n = 8), CD and HI (CHI, n = 8), HFD and sedentary (HS, n = 10), HFD and ME (HME, n = 8), and HFD and HI (HHI, n = 8). All exercise groups were trained for 10 weeks and had matched running distances. Dietary intake, body composition, blood metabolites, and corticosterone levels were measured. Histological lipid droplets were observed in the livers. The HFD led to hyperglycemia, hyperlipidemia and higher body fat (all, P 0.06), as well as higher corticosterone levels (P training improved fat weight, glucose, and lipid profiles, and reduced corticosterone levels (P training compared to ME training. Reductions in HFD-induced body weight gain, blood glucose and lipid profiles, and corticosterone levels, as well as improvements in QUICKI were better with HHI compared to HME. Correlation analyses revealed that corticosterone levels were significantly associated with phenotype variables (P training, HI training contributes to greater improvements in metabolic and corticosterone responses, leading to a greater reduction in susceptibility to HFD-induced disorders.

  17. Low-Intensity Agricultural Landscapes in Transylvania Support High Butterfly Diversity: Implications for Conservation

    Science.gov (United States)

    Loos, Jacqueline; Dorresteijn, Ine; Hanspach, Jan; Fust, Pascal; Rakosy, László; Fischer, Joern

    2014-01-01

    European farmland biodiversity is declining due to land use changes towards agricultural intensification or abandonment. Some Eastern European farming systems have sustained traditional forms of use, resulting in high levels of biodiversity. However, global markets and international policies now imply rapid and major changes to these systems. To effectively protect farmland biodiversity, understanding landscape features which underpin species diversity is crucial. Focusing on butterflies, we addressed this question for a cultural-historic landscape in Southern Transylvania, Romania. Following a natural experiment, we randomly selected 120 survey sites in farmland, 60 each in grassland and arable land. We surveyed butterfly species richness and abundance by walking transects with four repeats in summer 2012. We analysed species composition using Detrended Correspondence Analysis. We modelled species richness, richness of functional groups, and abundance of selected species in response to topography, woody vegetation cover and heterogeneity at three spatial scales, using generalised linear mixed effects models. Species composition widely overlapped in grassland and arable land. Composition changed along gradients of heterogeneity at local and context scales, and of woody vegetation cover at context and landscape scales. The effect of local heterogeneity on species richness was positive in arable land, but negative in grassland. Plant species richness, and structural and topographic conditions at multiple scales explained species richness, richness of functional groups and species abundances. Our study revealed high conservation value of both grassland and arable land in low-intensity Eastern European farmland. Besides grassland, also heterogeneous arable land provides important habitat for butterflies. While butterfly diversity in arable land benefits from heterogeneity by small-scale structures, grasslands should be protected from fragmentation to provide

  18. Moderate-to-high intensity aerobic exercise in patients with mild to moderate Alzheimer's disease

    DEFF Research Database (Denmark)

    Frederiksen, Kristian S; Sobol, Nanna; Beyer, Nina

    2014-01-01

    OBJECTIVES: Physical exercise may modulate neuropathology and symptoms of Alzheimer's disease (AD). This pilot study assessed the feasibility of conducting a study of moderate-to-high intensity aerobic exercise in home-dwelling patients with mild AD. METHODS: An uncontrolled preintervention...

  19. Edward Teller medal lecture: high intensity lasers and the road to ignition

    Energy Technology Data Exchange (ETDEWEB)

    Key, M.H.

    1997-06-02

    There has been much progress in the development of high intensity lasers and in the science of laser driven inertially confined fusion such that ignition is now a near term prospect. This lecture reviews the field with particular emphasis on areas of my own involvement.

  20. Dose estimation and shielding calculation for X-ray hazard at high intensity laser facilities

    Science.gov (United States)

    Qiu, Rui; Zhang, Hui; Yang, Bo; James, C. Liu; Sayed, H. Rokni; Michael, B. Woods; Li, Jun-Li

    2014-12-01

    An ionizing radiation hazard produced from the interaction between high intensity lasers and solid targets has been observed. Laser-plasma interactions create “hot” electrons, which generate bremsstrahlung X-rays when they interact with ions in the target. However, up to now only limited studies have been conducted on this laser-induced radiological protection issue. In this paper, the physical process and characteristics of the interaction between high intensity lasers and solid targets are analyzed. The parameters of the radiation sources are discussed, including the energy conversion efficiency from laser to hot electrons, hot electron energy spectrum and electron temperature, and the bremsstrahlung X-ray energy spectrum produced by hot electrons. Based on this information, the X-ray dose generated with high-Z targets for laser intensities between 1014 and 1020 W/cm2 is estimated. The shielding effects of common shielding items such as the glass view port, aluminum chamber wall and concrete wall are also studied using the FLUKA Monte Carlo code. This study provides a reference for the dose estimation and the shielding design of high intensity laser facilities.

  1. Burden of highly resistant microorganisms in a Dutch intensive care unit

    NARCIS (Netherlands)

    Aardema, H.; Arends, J. P.; de Smet, A. M. G. A.; Zijlstra, J. G.

    2015-01-01

    Background: The occurrence of highly resistant microorganisms (HRMOs) is a major threat to critical care patients, leading to worse outcomes, need for isolation measures, and demand for second-line or rescue antibiotics. The aim of this study was to quantify the burden of HRMOs in an intensive care

  2. Windowless microfluidic platform based on capillary burst valves for high intensity x-ray measurements

    DEFF Research Database (Denmark)

    Vig, Asger Laurberg; Haldrup, Kristoffer; Enevoldsen, Nikolaj Brandt;

    2009-01-01

    We propose and describe a microfluidic system for high intensity x-ray measurements. The required open access to a microfluidic channel is provided by an out-of-plane capillary burst valve (CBV). The functionality of the out-of-plane CBV is characterized with respect to the diameter of the window...

  3. Selected List of Low Energy Beam Transport Facilities for Light-Ion, High-Intensity Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Prost, L. R. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2016-02-17

    This paper presents a list of Low Energy Beam Transport (LEBT) facilities for light-ion, high-intensity accelerators. It was put together to facilitate comparisons with the PXIE LEBT design choices. A short discussion regarding the importance of the beam perveance in the choice of the transport scheme follows.

  4. A numerical and experimental investigation of the performance of sound intensity probes at high frequencies

    DEFF Research Database (Denmark)

    Jacobsen, Finn; Cutanda, Vicente; Juhl, Peter Møller

    1998-01-01

    The high-frequency performance of a p-p intensity probe with a solid spacer between the two microphones is examined. It is shown theoretically and verified experimentally that with a spacer length that equals the diameter of the microphones, the finite difference error is almost perfectly cancelled...

  5. Triggered Drug Release from Superhydrophobic Meshes using High-Intensity Focused Ultrasound

    OpenAIRE

    Yohe, Stefan T.; Kopechek, Jonathan A.; Porter, Tyrone M; Colson, Yolonda L.; Grinstaff, Mark W.

    2013-01-01

    Application of high-intensity focused ultrasound to drug-loaded superhydrophobic meshes affords triggered drug release by displacing an entrapped air layer. The air layer within the superhydrophobic meshes is characterized using direct visualization and B-mode imaging. Drug-loaded superhydrophobic meshes are cytotoxic in an in vitro assay after ultrasound treatment.

  6. Towards MR-guided high intensity focused ultrasound ablation of liver tumors

    NARCIS (Netherlands)

    Wijlemans, J.W.

    2015-01-01

    Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) is a promising technique which can be used for completely non-invasive tissue ablation. The converging ultrasound beam penetrates the skin and subcutaneous tissues with damage, while heating the tissue only in the focal point. The

  7. MRI-guided High-Intensity Focused Ultrasound of Breast Cancer

    NARCIS (Netherlands)

    Merckel, L.G.

    2014-01-01

    Magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) is a promising technique for completely noninvasive tumor ablation. This thesis focuses on its application for the treatment of patients with breast cancer. The first part of the thesis describes the role of breast MRI for

  8. Work in progress at the North Area High Intensity Facility (NAHIF)

    CERN Document Server

    1979-01-01

    The photo shows the exit of the two MBN-type magnets in tunnel TDC85 (upstream of TCC8), used to 'switch' the primary proton beam either towards target T8 (to the left) or onto target T10 (straight) to produce the H10 or the F12 (high-intensity electron/gamma) beam, respectively.

  9. 21 CFR 1040.30 - High-intensity mercury vapor discharge lamps.

    Science.gov (United States)

    2010-04-01

    ... mercury and that is contained within an outer envelope. (2) Advertisement means any catalog, specification... ballast is an inductive reactor designed to have the operating characteristics as listed in Section 7 in... advertisement. Advertising for any high-intensity mercury vapor discharge lamp that does not comply...

  10. Bone metastasis treatment using magnetic resonance-guided high intensity focused ultrasound

    NARCIS (Netherlands)

    Yeo, Sin Yuin; Elevelt, Aaldert; Donato, Katia; van Rietbergen, Bert; ter Hoeve, Natalie D.; van Diest, Paul J.; Grüll, Holger

    2015-01-01

    Objectives: Bone pain resulting from cancer metastases reduces a patient's quality of life. Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) is a promising alternative palliative thermal treatment technique for bone metastases that has been tested in a few clinical studies. Here

  11. Creatine supplementation spares muscle glycogen during high intensity intermittent exercise in rats

    Directory of Open Access Journals (Sweden)

    Costa André

    2010-01-01

    Full Text Available Abstract Background The effects of creatine (CR supplementation on glycogen content are still debatable. Thus, due to the current lack of clarity, we investigated the effects of CR supplementation on muscle glycogen content after high intensity intermittent exercise in rats. Methods First, the animals were submitted to a high intensity intermittent maximal swimming exercise protocol to ensure that CR-supplementation was able to delay fatigue (experiment 1. Then, the CR-mediated glycogen sparing effect was examined using a high intensity intermittent sub-maximal exercise test (fixed number of bouts; six bouts of 30-second duration interspersed by two-minute rest interval (experiment 2. For both experiments, male Wistar rats were given either CR supplementation or placebo (Pl for 5 days. Results As expected, CR-supplemented animals were able to exercise for a significant higher number of bouts than Pl. Experiment 2 revealed a higher gastrocnemius glycogen content for the CR vs. the Pl group (33.59%. Additionally, CR animals presented lower blood lactate concentrations throughout the intermittent exercise bouts compared to Pl. No difference was found between groups in soleus glycogen content. Conclusion The major finding of this study is that CR supplementation was able to spare muscle glycogen during a high intensity intermittent exercise in rats.

  12. Productions of hollow atoms from solids irradiated by high intensity laser

    Energy Technology Data Exchange (ETDEWEB)

    Moribayashi, K.; Sasaki, A.; Zhidkov, A. [Advanced Photon Research Center, Kansai Research Establishment, Japan Atomic Energy Research Inst. (Japan)

    2001-07-01

    The production of hollow atoms through the collisions of fast electrons with a solid is studied. These electrons are produced by high-intensity short-pulse laser irradiation on a solid. The inner-shell ionization and excitation processes by the fast electron impact are investigated. It is found that ionization processes give more significant contribution to the production of hollow atoms. (orig.)

  13. Status of High Intensity Polarized Electron Gun at Mit-Bates

    Science.gov (United States)

    Tsentalovich, E.; Bessuille, J.; Tiunov, M.

    2011-01-01

    MIT-Bates, in collaboration with BNL, has developed a high intensity polarized electron gun for the eRHIC project. The gun implements large area cathode, ring-shaped beam and active cathode cooling. The paper describes the current status of the project.

  14. The Edward Teller Medal Lecture: High Intensity Lasers and the Road to Ignition (lirpp Vol. 13)

    Science.gov (United States)

    Key, M. H.

    2016-10-01

    There has been much progress in the development of high intensity lasers and in the science of laser driven inertially confined fusion such that ignition is now a near term prospect. This lecture reviews the field with particular emphasis on areas of my own involvement.

  15. MRI-guided High-Intensity Focused Ultrasound of Breast Cancer

    NARCIS (Netherlands)

    Merckel, L.G.

    2014-01-01

    Magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) is a promising technique for completely noninvasive tumor ablation. This thesis focuses on its application for the treatment of patients with breast cancer. The first part of the thesis describes the role of breast MRI for

  16. High-level fusion of depth and intensity for pedestrian classification

    NARCIS (Netherlands)

    Rohrbach, M.; Enzweiler, M.; Gavrila, D.M.

    2009-01-01

    This paper presents a novel approach to pedestrian classification which involves a high-level fusion of depth and intensity cues. Instead of utilizing depth information only in a pre-processing step, we propose to extract discriminative spatial features (gradient orientation histograms and local

  17. Postexercise cold-water immersion improves intermittent high-intensity exercise performance in normothermia.

    Science.gov (United States)

    McCarthy, Avina; Mulligan, James; Egaña, Mikel

    2016-11-01

    A brief cold water immersion between 2 continuous high-intensity exercise bouts improves the performance of the latter compared with passive recovery in the heat. We investigated if this effect is apparent in normothermic conditions (∼19 °C), employing an intermittent high-intensity exercise designed to reflect the work performed at the high-intensity domain in team sports. Fifteen young active men completed 2 exhaustive cycling protocols (Ex1 and Ex2: 12 min at 85% ventilatory threshold (VT) and then an intermittent exercise alternating 30-s at 40% peak power (Ppeak) and 30 s at 90% Ppeak to exhaustion) separated by 15 min of (i) passive rest, (ii) 5-min cold-water immersion at 8 °C, and (iii) 10-min cold-water immersion at 8 °C. Core temperature, heart rate, rates of perceived exertion, and oxygen uptake kinetics were not different during Ex1 among conditions. Time to failure during the intermittent exercise was significantly (P intermittent high-intensity exercise compared with passive rest in normothermia due, at least in part, to reductions in core temperature, circulatory strain, and effort perception.

  18. Effects of 12 weeks high-intensity & reduced-volume training in elite athletes

    DEFF Research Database (Denmark)

    Kilen, Anders; Larsson, Tanja Hultengren; Jørgensen, Majke;

    2014-01-01

    It was investigated if high-intensity interval training (HIT) at the expense of total training volume improves performance, maximal oxygen uptake and swimming economy. 41 elite swimmers were randomly allocated to a control (CON) or HIT group. For 12 weeks both groups trained ∼12 h per week. HIT c...

  19. Responses of Plasma Atrial Natriuretic Peptide to High Intensity Submaximal Exercise in the Heat,

    Science.gov (United States)

    1987-06-01

    Natriuretic Peptide to LnHigh Intensity Submaximal Exercise in the Heat 0 " William J. Kraemer. Lawrence E. Armstrong, Roger W. Hubbard. :I[_] Louis J...atriopeptins in rat adrenal cells. Cir Res 57: 113-118. f V-0C -- V- - IF -I 7 - % 7 -. 17 Chartier L. Schiffrin EL. Thibault G (1984). Effects of atrial

  20. Ionization and acceleration of heavy ions in high-Z solid target irradiated by high intensity laser

    OpenAIRE

    Kawahito, D.; Kishimoto, Y

    2016-01-01

    In the interaction between high intensity laser and solid film, an ionization dynamics inside the solid is dominated by fast time scale convective propagation of the internal sheath field and the slow one by impact ionization due to heated high energy electrons coupled with nonlocal heat transport. Furthermore, ionization and acceleration due to the localized external sheath field which co- propagates with Al ions constituting the high energy front in the vacuum region. Through this process, ...

  1. Recharge heterogeneity and high intensity rainfall events increase contamination risk for Mediterranean groundwater resources

    Science.gov (United States)

    Hartmann, Andreas; Jasechko, Scott; Gleeson, Tom; Wada, Yoshihide; Andreo, Bartolomé; Barberá, Juan Antonio; Brielmann, Heike; Charlier, Jean-Baptiste; Darling, George; Filippini, Maria; Garvelmann, Jakob; Goldscheider, Nico; Kralik, Martin; Kunstmann, Harald; Ladouche, Bernard; Lange, Jens; Mudarra, Matías; Francisco Martín, José; Rimmer, Alon; Sanchez, Damián; Stumpp, Christine; Wagener, Thorsten

    2017-04-01

    Karst develops through the dissolution of carbonate rock and results in pronounced spatiotemporal heterogeneity of hydrological processes. Karst groundwater in Europe is a major source of fresh water contributing up to half of the total drinking water supply in some countries like Austria or Slovenia. Previous work showed that karstic recharge processes enhance and alter the sensitivity of recharge to climate variability. The enhanced preferential flow from the surface to the aquifer may be followed by enhanced risk of groundwater contamination. In this study we assess the contamination risk of karst aquifers over Europe and the Mediterranean using simulated transit time distributions. Using a new type of semi-distributed model that considers the spatial heterogeneity of karst hydraulic properties, we were able to simulate karstic groundwater recharge including its heterogeneous spatiotemporal dynamics. The model is driven by gridded daily climate data from the Global Land Data Assimilation System (GLDAS). Transit time distributions are calculated using virtual tracer experiments. We evaluated our simulations by independent information on transit times derived from observed time series of water isotopes of >70 karst springs over Europe. The simulations indicate that, compared to humid, mountain and desert regions, the Mediterranean region shows a stronger risk of contamination in Europe because preferential flow processes are most pronounced given thin soil layers and the seasonal abundance of high intensity rainfall events in autumn and winter. Our modelling approach includes strong simplifications and its results cannot easily be generalized but it still highlights that the combined effects of variable climate and heterogeneous catchment properties constitute a strong risk on water quality.

  2. The effect of position sources on estimated eigenvalues in intensity modeled data

    NARCIS (Netherlands)

    Hendrikse, Anne; Veldhuis, Raymond; Spreeuwers, Luuk; Goseling, Jasper; Weber, Jos H.

    2010-01-01

    In biometrics, often models are used in which the data distributions are approximated with normal distributions. In particular, the eigenface method models facial data as a mixture of fixed-position intensity signals with a normal distribution. The model parameters, a mean value and a covariance mat

  3. Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females

    Science.gov (United States)

    Winn, Nathan C.; Grunewald, Zachary I.; Liu, Ying; Heden, Timothy D.; Nyhoff, Lauren M.; Kanaley, Jill A.

    2017-01-01

    Background and Purpose Irisin is an exercise-responsive myokine that has been proposed to exert anti-obesity benefits; yet its response during exercise in obese women is not described. This study characterized plasma irisin levels during a single bout of afternoon isocaloric-exercise of different intensities (moderate- vs high-intensity) in obese females. Methods Eleven obese females participated in 3 randomized study days beginning at 1600h: 1) no exercise (NoEx), 2) moderate exercise (ModEx; 55%VO2max) and 3) high intensity interval exercise (IntEx; 4 min (80%VO2max)/3 min (50% VO2max). Frequent blood samples were analyzed for glucose and lactate (whole-blood), and insulin, c-peptide, glucagon, and irisin (plasma) throughout 190 min of testing. Results Plasma irisin increased above baseline during ModEx and IntEx (P0.05). Peak irisin levels during ModEx and IntEx exercise were 11.9± 3.4% and 12.3 ± 4.1% relative to baseline (Pexercise intensities (P>0.05). Irisin levels remained elevated above resting for 125 minutes post-exercise during ModEx, whereas levels returned to baseline within 15 minutes post-exercise during IntEx. Similarly, no associations were found between plasma irisin levels and circulating lactate, glucose, insulin, c-peptide, or glucagon among study days (P>0.05). However, there was an inverse association between basal irisin and lean mass (r = -0.70, P = 0.01). Conclusion A single bout of moderate and high intensity afternoon exercise induces modest increases in circulating irisin concentrations during exercise; however the regulation post-exercise appears to be dimorphic between exercise intensity in obese females. Future studies are needed to compare morning and afternoon exercise on irisin secretion. PMID:28125733

  4. New technologies in lighting systems for high-speed film and photography regarding high-intensity and heat problems

    Science.gov (United States)

    Severon, Burkhard

    1991-04-01

    Increasing frame rates and the heat sensibility of test objects forced the development of new lighting systems. For example at the automotive industry, where continuous light sources are indispensable for the high speed photography of car crash tests and automobile components tests, the further development of high efficient safety systems, so as Air-Bag systems, needs very datailed analysis of the accelerated motions. Frame rates from 2.000 up to 10.000 frames per second are requested and beside adequate camera systems and film material, this also means high intensive lighting systems. The need for high intensity could be easy achieved by the use of additional light fixtures but the request for more intensity comes along with the problem of heat. The test objects and the auxiliary materials become more and more temperature- sensitive. Very offen they have to be used under strict climate conditions. Mainly there where the test objects are already placed inside the illuminated area, the heat radiation of the light sources to the test objects have to be reduced. So high intensive, flicker free and less heat are today's requirements of light performance. This paper will present solutions to meet those demands.

  5. High-intensity focused ultrasound sonothrombolysis: the use of perfluorocarbon droplets to achieve clot lysis at reduced acoustic power.

    Science.gov (United States)

    Pajek, Daniel; Burgess, Alison; Huang, Yuexi; Hynynen, Kullervo

    2014-09-01

    The purpose of this study was to evaluate use of intravascular perfluorocarbon droplets to reduce the sonication power required to achieve clot lysis with high-intensity focused ultrasound. High-intensity focused ultrasound with droplets was initially applied to blood clots in an in vitro flow apparatus, and inertial cavitation thresholds were determined. An embolic model for ischemic stroke was used to illustrate the feasibility of this technique in vivo. Recanalization with intravascular droplets was achieved in vivo at 24 ± 5% of the sonication power without droplets. Recanalization occurred in 71% of rabbits that received 1-ms pulsed sonications during continuous intravascular droplet infusion (p = 0.041 vs controls). Preliminary experiments indicated that damage was confined to the ultrasonic focus, suggesting that tolerable treatments would be possible with a more tightly focused hemispheric array that allows the whole focus to be placed inside of the main arteries in the human brain.

  6. Solar intensity measurement using a thermoelectric module; experimental study and mathematical modeling

    DEFF Research Database (Denmark)

    Rahbar, Nader; Asadi, Amin

    2016-01-01

    The present study is intended to design, manufacture, and modeling an inexpensive pyranometer using a thermoelectric module. The governing equations relating the solar intensity, output voltage, and ambient temperature have been derived by applying the mathematical and thermodynamic models....... According to the thermodynamics modeling, the output voltage is a function of solar intensity, ambient temperature, internal parameters of thermoelectric module, convection and radiation coefficients, and geometrical characteristics of the setup. Moreover, the solar intensity can be considered as a linear...... function of voltage and ambient temperature within an acceptable range of accuracy. The experiments have been carried out on a typical winter day under climatic conditions of Semnan (35°33′N, 53°23′E), Iran. The results also indicated that the output voltage is dependent on the solar intensity and its...

  7. High harmonic generation from bulk diamond driven by intense femtosecond laser pulse

    CERN Document Server

    Apostolova, Tzveta

    2016-01-01

    We investigate the high-harmonic generation (HHG) from bulk diamond induced by intense 15 fs laser pulse and photon energy 1.55 eV. For laser intensity in the range $I \\in [1,50]$ TW/cm$^2$, we find that HHG spectra from diamond exhibits two plateaus with high harmonics extending beyond the 50th order. Consistently with experimental observations, we find that the cutoff energy of the two plateaus scales linearly with the field strength. The first plateau is due to recombination of electron-hole pairs near the Brillouin zone center. The appearance of weak second plateau region for high field strength with $F \\sim$ 1 V/$\\AA$ results in emission of highly energetic XUV photons.

  8. Recovery of a soil under different vegetation one year after a high intensity wildfire

    Directory of Open Access Journals (Sweden)

    A. Martín

    2013-05-01

    Full Text Available Studies on soil recovery in fragile ecosystems following high intensity wildfires are scarce. The aim of the present investigation is to evaluate the impact of a high intensity wildfire in an ecosystem under different vegetation (shrubland and pinewood located at Vilardevós (Galicia, NW Spain and highly susceptible to suffer soil erosion due to the steep relief and high erositivity of the rainfall. Soil samples were collected from the A horizon (0-5 cm 1 year after the fire and soil quality was evaluated by analysis of several physical, chemical and biochemical properties measured in the fraction chemical properties > physical properties. The data also showed that the fire impact was different depending on the soil vegetation considered (shrubland and pinewood. Moreover, the data confirmed the slow soil recovery in this fragile ecosystem and, therefore, the need of adopting post-fire stabilisation and rehabilitation treatments in order to minimize the post-fire erosion and soil degradation.

  9. High-Resolution Energy and Intensity Measurements with CVD Diamond at REX-ISOLDE

    CERN Document Server

    Griesmayer, E; Dobos, D; Wenander, F; Bergoz, J; Bayle, H; Frais-Kölbl, H; Leinweber, J; Aumeyr, T; CERN. Geneva. BE Department

    2009-01-01

    A novel beam instrumentation device for the HIE-REX (High In-tensity and Energy REX) upgrade has been developed and tested at the On-Line Isotope Mass Separator ISOLDE, located at the European Laboratory for Particle Physics (CERN). This device is based on CVD diamond detector technology and is used for measuring the beam intensity, particle counting and measuring the energy spectrum of the beam. An energy resolution of 0.6% was measured at a carbon ion energy of 22.8 MeV. This corresponds to an energy spread of ± 140 keV.

  10. Start-to-end simulations for the proposed Fermilab high intensity proton source

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Jean-Paul; Johnson, D.E.; Webber, R.C.; /Fermilab

    2007-06-01

    A High Intensity Proton Source consisting in an 8 GeV superconducting H-minus linac and transfer line to the Main Injector has been proposed. The primary mission is to increase the intensity of the Fermilab Main Injector for the production of neutrino superbeams. Start-to-end simulations from the RFQ to the stripping foil using the simulation code TRACK (ANL) is presented in this paper. In particular, we will study the impact of jitter errors on the H-minus phase space at the stripping foil.

  11. High-Energy Ions Emitted from Ar Clusters Irradiated by Intense Femtosecond Laser Pulses

    Institute of Scientific and Technical Information of China (English)

    LI Zhong; LEI An-Le; NI Guo-Quan; XU Zhi-Zhan

    2000-01-01

    We have experimentally studied the energy spectra of Ar ions emitted from Ar clusters irradiated by intense femtosecond laser pulses. The Ar clusters were produced in the adiabatic expansion of Ar gas into vacuum at high backing pressures. The laser peak intensity was about 2×106 W/cm2 with a pulse duration of 45 fs. The maximum and the average energies of Ar ions are 0.2 MeV and 15kev at a backing pressure of 2. S MPa, respectively. They are almost independent of the backing pressures in the range of 0.6 to 4.5 MPa.

  12. Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men.

    Science.gov (United States)

    Choi, Youngju; Akazawa, Nobuhiko; Zempo-Miyaki, Asako; Ra, Song-Gyu; Shiraki, Hitoshi; Ajisaka, Ryuichi; Maeda, Seiji

    2016-08-01

    Choi, Y, Akazawa, N, Zempo-Miyaki, A, Ra, S-G, Shiraki, H, Ajisaka, R, and Maeda, S. Acute effect of high-intensity eccentric exercise on vascular endothelial function in young men. J Strength Cond Res 30(8): 2279-2285, 2016-Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 ± 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and β-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r = 0.779; p ≤ 0.05), and a negative correlation was detected between change in β-stiffness index and change in FMD (r = -0.891; p eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.

  13. Psychophysiological effects of music on acute recovery from high-intensity interval training.

    Science.gov (United States)

    Jones, Leighton; Tiller, Nicholas B; Karageorghis, Costas I

    2017-03-01

    Numerous studies have examined the multifarious effects of music applied during exercise but few have assessed the efficacy of music as an aid to recovery. Music might facilitate physiological recovery via the entrainment of respiratory rhythms with music tempo. High-intensity exercise training is not typically associated with positive affective responses, and thus ways of assuaging negative affect warrant further exploration. This study assessed the psychophysiological effects of music on acute recovery and prevalence of entrainment in between bouts of high-intensity exercise. Thirteen male runners (Mage=20.2±1.9years; BMI=21.7±1.7; V̇O2 max=61.6±6.1mL·kg·min(-1)) completed three exercise sessions comprising 5×5-min bouts of high-intensity intervals interspersed with 3-min periods of passive recovery. During recovery, participants were administered positively-valenced music of a slow-tempo (55-65bpm), fast-tempo (125-135bpm), or a no-music control. A range of measures including affective responses, RPE, cardiorespiratory indices (gas exchange and pulmonary ventilation), and music tempo-respiratory entrainment were recorded during exercise and recovery. Fast-tempo, positively-valenced music resulted in higher Feeling Scale scores throughout recovery periods (p<0.01, ηp(2)=0.38). There were significant differences in HR during initial recovery periods (p<0.05, ηp(2)=0.16), but no other music-moderated differences in cardiorespiratory responses. In conclusion, fast-tempo, positively-valenced music applied during recovery periods engenders a more pleasant experience. However, there is limited evidence that music expedites cardiorespiratory recovery in between bouts of high-intensity exercise. These findings have implications for athletic training strategies and individuals seeking to make high-intensity exercise sessions more pleasant.

  14. Magnetic resonance imaging of boiling induced by high intensity focused ultrasound.

    Science.gov (United States)

    Khokhlova, Tatiana D; Canney, Michael S; Lee, Donghoon; Marro, Kenneth I; Crum, Lawrence A; Khokhlova, Vera A; Bailey, Michael R

    2009-04-01

    Both mechanically induced acoustic cavitation and thermally induced boiling can occur during high intensity focused ultrasound (HIFU) medical therapy. The goal was to monitor the temperature as boiling was approached using magnetic resonance imaging (MRI). Tissue phantoms were heated for 20 s in a 4.7-T magnet using a 2-MHz HIFU source with an aperture and radius of curvature of 44 mm. The peak focal pressure was 27.5 MPa with corresponding beam width of 0.5 mm. The temperature measured in a single MRI voxel by water proton resonance frequency shift attained a maximum value of only 73 degrees C after 7 s of continuous HIFU exposure when boiling started. Boiling was detected by visual observation, by appearance on the MR images, and by a marked change in the HIFU source power. Nonlinear modeling of the acoustic field combined with a heat transfer equation predicted 100 degrees C after 7 s of exposure. Averaging of the calculated temperature field over the volume of the MRI voxel (0.3 x 0.5 x 2 mm(3)) yielded a maximum of 73 degrees C that agreed with the MR thermometry measurement. These results have implications for the use of MRI-determined temperature values to guide treatments with clinical HIFU systems.

  15. Development and characterization of a blood mimicking fluid for high intensity focused ultrasound.

    Science.gov (United States)

    Liu, Yunbo; Maruvada, Subha; King, Randy L; Herman, Bruce A; Wear, Keith A

    2008-09-01

    A blood mimicking fluid (BMF) has been developed for the acoustic and thermal characterizations of high intensity focused ultrasound (HIFU) ablation devices. The BMF is based on a degassed and de-ionized water solution dispersed with low density polyethylene microspheres, nylon particles, gellan gum, and glycerol. A broad range of physical parameters, including attenuation coefficient, speed of sound, viscosity, thermal conductivity, and diffusivity, were characterized as a function of temperature (20-70 degrees C). The nonlinear parameter B/A and backscatter coefficient were also measured at room temperature. Importantly, the attenuation coefficient is linearly proportional to the frequency (2-8 MHz) with a slope of about 0.2 dB cm(-1) MHz(-1) in the 20-70 degrees C range as in the case of human blood. Furthermore, sound speed and bloodlike backscattering indicate the usefulness of the BMF for ultrasound flow imaging and ultrasound-guided HIFU applications. Most of the other temperature-dependent physical parameters are also close to the reported values in human blood. These properties make it a unique HIFU research tool for developing standardized exposimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU ablation devices.

  16. Heightened serotonin influences contest outcome and enhances expression of high-intensity aggressive behaviors.

    Science.gov (United States)

    Bubak, Andrew N; Renner, Kenneth J; Swallow, John G

    2014-02-01

    The outcome of behavioral interactions between organisms can have significant fitness implications. Therefore, it is of great theoretical and practical importance to understand the mechanisms that modify different agonistic behaviors. Changes in central monoamines, such as serotonin (5-HT), contribute to modifying the expression of aggressive encounters in both vertebrates and invertebrates. In several invertebrate groups, neural 5-HT has been linked to heightened aggression and conflict escalation. The male stalk-eyed fly (Teleopsis dalmanni) competes with conspecifics daily over access to resources such as food and mates. Because encounters escalate in a stereotypical manner, stalk-eyed flies provide an excellent model system to study behavioral syndromes. We hypothesized that noninvasive, pharmacological augmentation of brain 5-HT by administration of the precursor, 5-hydroxytryptophan (5-HTP), would increase stereotypic behavioral escalation and the probability of winning a conflict over food. Size-matched male 5-HTP-treated and untreated flies were placed in a forced-fight paradigm and their aggressive behaviors scored. Individuals with higher brain 5-HT levels had a markedly higher probability of winning the contests, displayed greater levels of high-intensity aggressive behaviors and fewer retreats. Pretreatment with 5-HTP did not significantly alter octopamine or tyramine, suggesting that central 5-HT may modulate aggression in these organisms and play a role in determining reproductive success and resource attainment.

  17. Intensive lifestyle intervention including high-intensity interval training program improves insulin resistance and fasting plasma glucose in obese patients

    Directory of Open Access Journals (Sweden)

    Guillaume Marquis-Gravel

    2015-01-01

    Conclusion: Following a 9-month intensive lifestyle intervention combining HIIT and MedD counseling, obese subjects experienced significant improvements of FPG and insulin resistance. This is the first study to expose the effects of a long-term program combining HIIT and MedD on glycemic control parameters among obese subjects.

  18. Using high-fidelity simulation as a learning strategy in an undergraduate intensive care course.

    Science.gov (United States)

    Badir, Aysel; Zeybekoğlu, Zuhal; Karacay, Pelin; Göktepe, Nilgün; Topcu, Serpil; Yalcin, Begüm; Kebapci, Ayda; Oban, Gül

    2015-01-01

    Using high-fidelity simulations to facilitate student learning is an uncommon practice in Turkish nursing programs. The aim of the present study was to understand students' perceptions of the use of simulation in nursing courses. Subjects included 36 senior nursing students taking an intensive care course. This study revealed that high-fidelity simulation is an ideal method of promoting learning by helping students transfer theory into practice, build confidence and teamwork, and raise professional awareness.

  19. Personalized Metabolomics for Predicting Glucose Tolerance Changes in Sedentary Women After High-Intensity Interval Training

    OpenAIRE

    Kuehnbaum, Naomi L.; Gillen, Jenna B.; Gibala, Martin J.; Britz-McKibbin, Philip

    2014-01-01

    High-intensity interval training (HIIT) offers a practical approach for enhancing cardiorespiratory fitness, however its role in improving glucose regulation among sedentary yet normoglycemic women remains unclear. Herein, multi-segment injection capillary electrophoresis-mass spectrometry is used as a high-throughput platform in metabolomics to assess dynamic responses of overweight/obese women (BMI > 25, n = 11) to standardized oral glucose tolerance tests (OGTTs) performed before and after...

  20. Report from the NSLS workshop: Sources and applications of high intensity uv-vuv light

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, E.D.; Hastings, J.B. [eds.

    1990-12-31

    A workshop was held to evaluate sources and applications of high intensity, ultra violet (UV) radiation for biological, chemical, and materials sciences. The proposed sources are a UV free electron laser (FEL) driven by a high brightness linac and undulators in long, straight sections of a specially designed low energy (400 MeV) storage ring. These two distinct types of sources will provide a broad range of scientific opportunities that were discussed in detail during the workshop.