WorldWideScience

Sample records for modeling framework mmf

  1. The Impact of Model Resolution and Configuration on Rainfall Characteristics in a Multi-scale Modeling Framework (MMF)

    Science.gov (United States)

    Chern, J. D.; Tao, W. K.

    2016-12-01

    The multiscale modeling framework (MMF), which replaces traditional cloud parameterizations with cloud-resolving models (CRMs) within a host atmospheric general circulation model (GCM), has become a promising approach for climate modeling. Despite the overall success of MMFs in simulating the MJO, diurnal variability, and mesoscale convective systems, phenomena difficult for traditional GCMs to simulate well, systematic model deficits in MMFs do exist. One of the major biases for all MMFs is the overestimation of surface rainfall over the West Pacific, South Pacific Convergence Zone (SPCZ), and Indian Ocean. Many hypotheses have been proposed such as the use of cyclic lateral boundary condition in embedded 2D CRMs, the orientation of the 2D CRM and momentum transport, and the nonlinear feedback of wind and surface evaporation, but the tropical positive precipitation biases still persist in all MMFs. In this study, the Goddard MMFs and the stand-alone Goddard Cumulus Ensemble (GCE, a CRM) are used to study the impacts of model resolution and model domain size on the surface precipitation and rainfall characteristics. A series of GCE and MMF simulations have been carried out with different model configuration. The changes of cloud structure, occurrence, and properties such as cloud types, updraft and downdraft, latent heating profile, and cold pool strength in both stand-alone CRMs and the ones embedded inside the MMF are examined in details. We also focus on the multi-scale interaction and feedback in the MMF to understand why the tropica positive precipitation bias and root-mean-square error decrease with decreasing (increasing) GCE grid size (domain).

  2. A Multithreaded Missions And Means Framework (MMF) Concept Report

    Science.gov (United States)

    2012-03-01

    A Multithreaded Missions and Means Framework ( MMF ) Concept Report by Peter J. Grazaitis and Brian G. Ruth ARL-TR-5948 March 2012...A Multithreaded Missions and Means Framework ( MMF ) Concept Report Peter J. Grazaitis Human Research and Engineering Directorate, ARL Brian G...TYPE Final 3. DATES COVERED (From - To) 1 October 2010–20 September 2011 4. TITLE AND SUBTITLE A Multithreaded Missions and Means Framework ( MMF

  3. Correlation Between the System Capabilities Analytic Process (SCAP) and the Missions and Means Framework (MMF)

    Science.gov (United States)

    2013-05-01

    Correlation Between the System Capabilities Analytic Process (SCAP) and the Missions and Means Framework ( MMF ) by Kevin S. Agan ARL-TR...ARL-TR-6455 May 2013 Correlation Between the System Capabilities Analytic Process (SCAP) and the Missions and Means Framework ( MMF ) Kevin...Analytic Process (SCAP) and the Missions and Means Framework ( MMF ) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S

  4. Aerosol indirect effects in a multi-scale aerosol-climate model PNNL-MMF

    Directory of Open Access Journals (Sweden)

    M. Wang

    2011-06-01

    Full Text Available Much of the large uncertainty in estimates of anthropogenic aerosol effects on climate arises from the multi-scale nature of the interactions between aerosols, clouds and dynamics, which are difficult to represent in conventional general circulation models (GCMs. In this study, we use a multi-scale aerosol-climate model that treats aerosols and clouds across multiple scales to study aerosol indirect effects. This multi-scale aerosol-climate model is an extension of a multi-scale modeling framework (MMF model that embeds a cloud-resolving model (CRM within each vertical column of a GCM grid. The extension allows a more physically-based treatment of aerosol-cloud interactions in both stratiform and convective clouds on the global scale in a computationally feasible way. Simulated model fields, including liquid water path (LWP, ice water path, cloud fraction, shortwave and longwave cloud forcing, precipitation, water vapor, and cloud droplet number concentration are in reasonable agreement with observations. The new model performs quantitatively similar to the previous version of the MMF model in terms of simulated cloud fraction and precipitation. The simulated change in shortwave cloud forcing from anthropogenic aerosols is −0.77 W m−2, which is less than half of that (−1.79 W m−2 calculated by the host GCM (NCAR CAM5 with traditional cloud parameterizations and is also at the low end of the estimates of other conventional global aerosol-climate models. The smaller forcing in the MMF model is attributed to a smaller (3.9 % increase in LWP from preindustrial conditions (PI to present day (PD compared with 15.6 % increase in LWP in stratiform clouds in CAM5. The difference is caused by a much smaller response in LWP to a given perturbation in cloud condensation nuclei (CCN concentrations from PI to PD in the MMF (about one-third of that in CAM5, and, to a lesser extent, by a smaller relative increase in CCN

  5. Metal-macrocycle framework (MMF): supramolecular nano-channel surfaces with shape sorting capability.

    Science.gov (United States)

    Tashiro, Shohei; Kubota, Ryou; Shionoya, Mitsuhiko

    2012-02-08

    Hollow nanostructures for the functional assembly of chemical groups with inner surface geometry and regulable stoichiometry enable steric design of interior reaction centers. Herein we report a metal-macrocycle framework (MMF) that forms single-crystalline nanochannels with five distinct enantiomeric pairs of guest binding pockets. During crystal-soaking experiments, the MMF crystals can encapsulate aromatic molecules with high site selectivity. First, constitutional isomers of dibromobenzene are captured and sorted into different binding pockets. Second, each of the optical isomers of (1R/1S)-1-(3-chlorophenyl)ethanol is included diastereoselectively into one of an enantiomeric pair of binding pockets. An advantage of this strategy is that the interior walls can be "repainted" via replacement of the trapped molecules with alternatives. Such guest uptake behaviors would allow highly regioselective or stereoselective reactions within the nanochannel.

  6. The multi-scale aerosol-climate model PNNL-MMF: model description and evaluation

    Directory of Open Access Journals (Sweden)

    M. Wang

    2011-03-01

    Full Text Available Anthropogenic aerosol effects on climate produce one of the largest uncertainties in estimates of radiative forcing of past and future climate change. Much of this uncertainty arises from the multi-scale nature of the interactions between aerosols, clouds and large-scale dynamics, which are difficult to represent in conventional general circulation models (GCMs. In this study, we develop a multi-scale aerosol-climate model that treats aerosols and clouds across different scales, and evaluate the model performance, with a focus on aerosol treatment. This new model is an extension of a multi-scale modeling framework (MMF model that embeds a cloud-resolving model (CRM within each grid column of a GCM. In this extension, the effects of clouds on aerosols are treated by using an explicit-cloud parameterized-pollutant (ECPP approach that links aerosol and chemical processes on the large-scale grid with statistics of cloud properties and processes resolved by the CRM. A two-moment cloud microphysics scheme replaces the simple bulk microphysics scheme in the CRM, and a modal aerosol treatment is included in the GCM. With these extensions, this multi-scale aerosol-climate model allows the explicit simulation of aerosol and chemical processes in both stratiform and convective clouds on a global scale.

    Simulated aerosol budgets in this new model are in the ranges of other model studies. Simulated gas and aerosol concentrations are in reasonable agreement with observations (within a factor of 2 in most cases, although the model underestimates black carbon concentrations at the surface by a factor of 2–4. Simulated aerosol size distributions are in reasonable agreement with observations in the marine boundary layer and in the free troposphere, while the model underestimates the accumulation mode number concentrations near the surface, and overestimates the accumulation mode number concentrations in the middle and upper free troposphere by a factor

  7. The multi-scale aerosol-climate model PNNL-MMF: model description and evaluation

    Science.gov (United States)

    Wang, M.; Ghan, S.; Easter, R.; Ovchinnikov, M.; Liu, X.; Kassianov, E.; Qian, Y.; Gustafson, W. I., Jr.; Larson, V. E.; Schanen, D. P.; Khairoutdinov, M.; Morrison, H.

    2011-03-01

    Anthropogenic aerosol effects on climate produce one of the largest uncertainties in estimates of radiative forcing of past and future climate change. Much of this uncertainty arises from the multi-scale nature of the interactions between aerosols, clouds and large-scale dynamics, which are difficult to represent in conventional general circulation models (GCMs). In this study, we develop a multi-scale aerosol-climate model that treats aerosols and clouds across different scales, and evaluate the model performance, with a focus on aerosol treatment. This new model is an extension of a multi-scale modeling framework (MMF) model that embeds a cloud-resolving model (CRM) within each grid column of a GCM. In this extension, the effects of clouds on aerosols are treated by using an explicit-cloud parameterized-pollutant (ECPP) approach that links aerosol and chemical processes on the large-scale grid with statistics of cloud properties and processes resolved by the CRM. A two-moment cloud microphysics scheme replaces the simple bulk microphysics scheme in the CRM, and a modal aerosol treatment is included in the GCM. With these extensions, this multi-scale aerosol-climate model allows the explicit simulation of aerosol and chemical processes in both stratiform and convective clouds on a global scale. Simulated aerosol budgets in this new model are in the ranges of other model studies. Simulated gas and aerosol concentrations are in reasonable agreement with observations (within a factor of 2 in most cases), although the model underestimates black carbon concentrations at the surface by a factor of 2-4. Simulated aerosol size distributions are in reasonable agreement with observations in the marine boundary layer and in the free troposphere, while the model underestimates the accumulation mode number concentrations near the surface, and overestimates the accumulation mode number concentrations in the middle and upper free troposphere by a factor of about 2. The

  8. Algorithms of D-optimal designs for Morgan Mercer Flodin (MMF) models with three parameters

    Science.gov (United States)

    Widiharih, Tatik; Haryatmi, Sri; Gunardi, Wilandari, Yuciana

    2016-02-01

    Morgan Mercer Flodin (MMF) model is used in many areas including biological growth studies, animal and husbandry, chemistry, finance, pharmacokinetics and pharmacodynamics. Locally D-optimal designs for Morgan Mercer Flodin (MMF) models with three parameters are investigated. We used the Generalized Equivalence Theorem of Kiefer and Wolvowitz to determine D-optimality criteria. Number of roots for standardized variance are determined using Tchebysheff system concept and it is used to decide that the design is minimally supported design. In these models, designs are minimally supported designs with uniform weight on its support, and the upper bound of the design region is a support point.

  9. The multi-scale aerosol-climate model PNNL-MMF: model description and evaluation

    Directory of Open Access Journals (Sweden)

    M. Wang

    2010-10-01

    Full Text Available Anthropogenic aerosol effects on climate produce one of the largest uncertainties in estimates of radiative forcing of past and future climate change. Much of this uncertainty arises from the multi-scale nature of the interactions between aerosols, clouds and large-scale dynamics, which are difficult to represent in conventional global climate models (GCMs. In this study, we develop a multi-scale aerosol climate model that treats aerosols and clouds across different scales, and evaluate the model performance, with a focus on aerosol treatment. This new model is an extension of a multi-scale modeling framework (MMF model that embeds a cloud-resolving model (CRM within each grid column of a GCM. In this extension, the effects of clouds on aerosols are treated by using an explicit-cloud parameterized-pollutant (ECPP approach that links aerosol and chemical processes on the large-scale grid with statistics of cloud properties and processes resolved by the CRM. A two-moment cloud microphysics scheme replaces the simple bulk microphysics scheme in the CRM, and a modal aerosol treatment is included in the GCM. With these extensions, this multi-scale aerosol-climate model allows the explicit simulation of aerosol and chemical processes in both stratiform and convective clouds on a global scale.

    Simulated aerosol budgets in this new model are in the ranges of other model studies. Simulated gas and aerosol concentrations are in reasonable agreement with observations, although the model underestimates black carbon concentrations at the surface. Simulated aerosol size distributions are in reasonable agreement with observations in the marine boundary layer and in the free troposphere, while the model underestimates the accumulation mode number concentrations near the surface, and overestimates the accumulation number concentrations in the free troposphere. Simulated cloud condensation nuclei (CCN concentrations are within the observational

  10. Theoretical Calculation of MMF's Bandwidth

    Institute of Scientific and Technical Information of China (English)

    LI Xiao-fu; JIANG De-sheng; YU Hai-hu

    2004-01-01

    The difference between over-filled launch bandwidth (OFL BW) and restricted mode launch bandwidth (RML BW) is described. A theoretical model is founded to calculate the OFL BW of grade index multimode fiber (GI-MMF),and the result is useful to guide the modification of the manufacturing method.

  11. MMF and eye disease.

    Science.gov (United States)

    Zierhut, M; Stübiger, N; Siepmann, K; Deuter, C M E

    2005-01-01

    Immunosuppressive treatment has shown to be effective in various ocular inflammatory disorders. Factors limiting their use are the individual response and the rate of side effects. This report summarizes our knowledge about the use of mycophenolate mofetil (MMF) in the treatment of ocular cicatricial pemphigoid (OCP), uveitis, atopic keratoconjunctivitis (AKC), prevention of graft rejection after penetrating keratoplasty (PK) and scleritis. Controlled studies have been performed for prevention of graft rejection after PK, showing MMF as effective in the prevention of graft rejection as cyclosporine A. In experimental uveitis, MMF has been demonstrated to be highly effective in prevention of retinal destruction. A number of studies have now shown that MMF also seems effective in uveitis. There are also studies with smaller patient groups which point out the effectiveness of MMF in OCP, AKC, and scleritis. In most of the studies, the spectrum of side effects was small, compared to other immunosuppressives.

  12. MMF: Outlook for 2007

    Institute of Scientific and Technical Information of China (English)

    Wang Ting

    2007-01-01

    @@ As experts estimated that MMF industry in China has already stepped into a new uptrend period in the year of 2007, however, the negative factors could not be ignored while we were nodding at the expectation in the new year.

  13. Use of ARM Data to address the Climate Change Further Development and Applications of A Multi-scale Modeling Framework

    Energy Technology Data Exchange (ETDEWEB)

    David A. Randall; Marat Khairoutdinov

    2007-12-14

    The Colorado State University (CSU) Multi-scale Modeling Framework (MMF) is a new type of general circulation model (GCM) that replaces the conventional parameterizations of convection, clouds and boundary layer with a cloud-resolving model (CRM) embedded into each grid column. The MMF that we have been working with is a “super-parameterized” version of the Community Atmosphere Model (CAM). As reported in the publications listed below, we have done extensive work with the model. We have explored the MMF’s performance in several studies, including an AMIP run and a CAPT test, and we have applied the MMF to an analysis of climate sensitivity.

  14. MMF, Exports Surpassed imports

    Institute of Scientific and Technical Information of China (English)

    Wang Ting

    2007-01-01

    @@ Due to the fluctuation of the price of raw material, MMF market had a very unstable 2006. In the first five months, domestic market preserved stable and appeared to rise slightly. Till June, the soaring price of raw material pushed the price of synthetic fiber to increase a lot quickly, but fell down sharply since the middle September lasting to the early October, as the price of crude oil descending at the same time.

  15. Improving NASA's Multiscale Modeling Framework for Tropical Cyclone Climate Study

    Science.gov (United States)

    Shen, Bo-Wen; Nelson, Bron; Cheung, Samson; Tao, Wei-Kuo

    2013-01-01

    One of the current challenges in tropical cyclone (TC) research is how to improve our understanding of TC interannual variability and the impact of climate change on TCs. Recent advances in global modeling, visualization, and supercomputing technologies at NASA show potential for such studies. In this article, the authors discuss recent scalability improvement to the multiscale modeling framework (MMF) that makes it feasible to perform long-term TC-resolving simulations. The MMF consists of the finite-volume general circulation model (fvGCM), supplemented by a copy of the Goddard cumulus ensemble model (GCE) at each of the fvGCM grid points, giving 13,104 GCE copies. The original fvGCM implementation has a 1D data decomposition; the revised MMF implementation retains the 1D decomposition for most of the code, but uses a 2D decomposition for the massive copies of GCEs. Because the vast majority of computation time in the MMF is spent computing the GCEs, this approach can achieve excellent speedup without incurring the cost of modifying the entire code. Intelligent process mapping allows differing numbers of processes to be assigned to each domain for load balancing. The revised parallel implementation shows highly promising scalability, obtaining a nearly 80-fold speedup by increasing the number of cores from 30 to 3,335.

  16. Evaluating and Improving Cloud Processes in the Multi-Scale Modeling Framework

    Energy Technology Data Exchange (ETDEWEB)

    Ackerman, Thomas P. [Univ. of Washington, Seattle, WA (United States)

    2015-03-01

    The research performed under this grant was intended to improve the embedded cloud model in the Multi-scale Modeling Framework (MMF) for convective clouds by using a 2-moment microphysics scheme rather than the single moment scheme used in all the MMF runs to date. The technical report and associated documents describe the results of testing the cloud resolving model with fixed boundary conditions and evaluation of model results with data. The overarching conclusion is that such model evaluations are problematic because errors in the forcing fields control the results so strongly that variations in parameterization values cannot be usefully constrained

  17. Mycophenolate mofetil (MMF) does not slow the progression of subclinical atherosclerosis in SLE over 2 years.

    Science.gov (United States)

    Kiani, Adnan N; Magder, Laurence S; Petri, Michelle

    2012-09-01

    Accelerated atherosclerosis is a major cause of mortality in SLE. Mycophenolate mofetil (MMF) has been shown to suppress growth factor-induced proliferation of vascular smooth muscle and endothelial cells in animal models. We hypothesized that MMF might modify the inflammatory component of atherosclerosis in SLE. We examined the effect of MMF on atherosclerosis as measured by changes in carotid intima-media thickness (IMT) or coronary artery calcium (CAC) over 2 years. CAC and carotid IMT were measured at baseline and 2 years later in a cohort of 187 patients with SLE. The cohort was 91% women, 59% Caucasian, and 35% African-American, with a mean age of 45 ± 11 years. Of these, 12.5% (n = 25) received MMF during follow-up. The daily dose ranged from 500 to 3,000 mg/day, and duration ranged from 84 days to the entire 2 years. We divided MMF users into three groups: low exposure (MMF (MMF: 1.17-1.28, low MMF: 1.02-1.13, high MMF: 1.44-1.61, and any MMF: 1.21-1.34 log-Agatston units. Compared to no MMF, there was no statistically different change between the three groups (p = 0.99, 0.87, and 0.91). Similarly, mean carotid IMT increased in all four groups: no MMF: 0.58-0.66, low MMF: 0.55-0.60, high MMF: 0.56-0.71, and any MMF: 0.56-0.66. We then adjusted for statin use, lupus nephritis, body mass index, systolic blood pressure, cholesterol, and age during the 2-year follow-up. The association between MMF exposure and change in CAC or carotid IMT was not statistically significant (p = 0.63 for CAC, and p = 0.085 for carotid IMT). There was no evidence that MMF slowed or decreased the progression of atherosclerosis as measured by carotid IMT or CAC. Because the number of patients taking MMF was only twenty-five, larger studies for longer time periods are needed to explore any effect of MMF on subclinical atherosclerosis in SLE.

  18. The safety and efficacy of MMF in lupus nephritis: a pilot study.

    Science.gov (United States)

    Kingdon, E J; McLean, A G; Psimenou, E; Davenport, A; Powis, S H; Sweny, P; Burns, A

    2001-01-01

    Inducing and maintaining remission in patients with lupus nephritis may be difficult. Current treatments have significant toxicity. Mycophenolate mofetil (MMF) limits damage in murine models of lupus nephritis. We have assessed the efficacy and tolerability of MMF in the treatment of patients with long-standing or resistant lupus nephritis. We have treated 13 patients with biopsy proven lupus nephritis (two membranous nephropathy, four membranous nephropathy with superimposed proliferative changes, seven with proliferative glomerulonephritis). All patients had relapsed on conventional treatment or there were pressing indications to minimise steroid dosage or avoid alkylating agents. Nine out of 13 were treated with MMF and prednisolone, 3/10 with MMF alone and 1/10 with MMF, prednisolone and cyclosporine. Thirteen patients were treated with MMF for up to 37 months (median 25 months). Three patients were withdrawn from MMF during the first 8 months of treatment. The remainder tolerated MMF (median dose 1 g/day). Serological improvements were observed in 9/13 and steroid dosage was reduced in 8/10 patients. Infections occurred in 3/13. One patient relapsed. MMF significantly reduced the rate of decline of renal function. MMF should be considered in the treatment of long-standing or resistant lupus nephritis. Controlled clinical trials are required to confirm these findings.

  19. Mycophenolate mofetil (MMF) does not slow the progression of subclinical atherosclerosis in SLE over 2 years

    OpenAIRE

    KIANI, ADNAN N.; Magder, Laurence S.; Petri, Michelle

    2011-01-01

    Accelerated atherosclerosis is a major cause of mortality in SLE. Mycophenolate mofetil (MMF) has been shown to suppress growth factor-induced proliferation of vascular smooth muscle and endothelial cells in animal models. We hypothesized that MMF might modify the inflammatory component of atherosclerosis in SLE. We examined the effect of MMF on atherosclerosis as measured by changes in carotid intima–media thickness (IMT) or coronary artery calcium (CAC) over 2 years. CAC and carotid IMT wer...

  20. Evaluating the Performance of the Goddard Multi-Scale Modeling Framework with Different Cloud Microphysical Schemes

    Science.gov (United States)

    Chern, J.; Tao, W.; Lang, S. E.; Matsui, T.

    2012-12-01

    The accurate representation of clouds and cloud processes in atmospheric general circulation models (GCMs) with relatively coarse resolution (~100 km) has been a long-standing challenge. With the rapid advancement in computational technology, new breed of GCMs that are capable of explicitly resolving clouds have been developed. Though still computationally very expensive, global cloud-resolving models (GCRMs) with horizontal resolutions of 3.5 to 14 km are already being run in an exploratory manner. Another less computationally demanding approach is the multi-scale modeling framework (MMF) that replaces conventional cloud parameterizations with a cloud-resolving model (CRM) in each grid column of a GCM. The Goddard MMF is based on the coupling of the Goddard Cumulus Ensemble (GCE), a CRM model, and the GEOS global model. In recent years a few new and improved microphysical schemes are developed and implemented to the GCE based on observations from field campaigns. It is important to evaluating these microphysical schemes for global applications such as the MMFs and GCRMs. Two-year (2007-2008) MMF sensitivity experiments have been carried out with different cloud microphysical schemes. The model simulated mean and variability of surface precipitation, cloud types, cloud properties such as cloud amount, hydrometeors vertical profiles, and cloud water contents, etc. in different geographic locations and climate regimes are evaluated against TRMM, CloudSat and CALIPSO satellite observations. The Goddard MMF has also been coupled with the Goddard Satellite Data Simulation Unit (G-SDSU), a system with multi-satellite, multi-sensor, and multi-spectrum satellite simulators. The statistics of MMF simulated radiances and backscattering can be directly compared with satellite observations to evaluate the performance of different cloud microphysical schemes. We will assess the strengths and/or deficiencies in of these microphysics schemes and provide guidance on how to improve

  1. Evaluation the Quality of Cloud Dataset from the Goddard Multi-Scale Modeling Framework for Supporting GPM Algorithm Development

    Science.gov (United States)

    Chern, J.; Tao, W.; Mohr, K. I.; Matsui, T.; Lang, S. E.

    2013-12-01

    With recent rapid advancement in computational technology, the multi-scale modeling framework (MMF) that replaces conventional cloud parameterizations with a cloud-resolving model (CRM) in each grid column of a GCM has been developed and improved at NASA Goddard. The Goddard MMF is based on the coupling of the Goddard Cumulus Ensemble (GCE), a CRM model, and the Goddard GEOS global model. In recent years, a few new and improved microphysical schemes are developed and implemented to the GCE based on observations from field campaigns. These schemes have been incorporated into the MMF. The MMF has global coverage and can provide detailed cloud properties such as cloud amount, hydrometeors types, and vertical profile of water contents at high spatial and temporal resolution of a cloud-resolving model. When coupled with the Goddard Satellite Data Simulation Unit (GSDSU), a system with multi-satellite, multi-sensor, and multi-spectrum satellite simulators, the MMF system can provide radiances and backscattering similar to what satellite directly observed. In this study, one-year (2007) MMF simulation has been performed with the new 4-ice (cloud ice, snow, graupel and hail) microphysical scheme. The GEOS global model is run at 2o x 2.5o resolution and the embedded two-dimensional GCEs each has 64 columns at 4 km horizontal resolution. The large-scale forcing from the GCM is nudged to EC-Interim analysis to reduce the influence of MMF model biases on the cloud-resolving model results. The simulation provides more than 300 millions of vertical profiles of cloud dataset in different season, geographic locations, and climate regimes. This cloud dataset is used to supplement observations over data sparse areas for supporting GPM algorithm development. The model simulated mean and variability of surface rainfall and snowfall, cloud and precipitation types, cloud properties, radiances and backscattering are evaluated against satellite observations. We will assess the strengths

  2. Parallel MMF: a Multiresolution Approach to Matrix Computation

    OpenAIRE

    Kondor, Risi; Teneva, Nedelina; Mudrakarta, Pramod K.

    2015-01-01

    Multiresolution Matrix Factorization (MMF) was recently introduced as a method for finding multiscale structure and defining wavelets on graphs/matrices. In this paper we derive pMMF, a parallel algorithm for computing the MMF factorization. Empirically, the running time of pMMF scales linearly in the dimension for sparse matrices. We argue that this makes pMMF a valuable new computational primitive in its own right, and present experiments on using pMMF for two distinct purposes: compressing...

  3. Collaborative Project. A Flexible Atmospheric Modeling Framework for the Community Earth System Model (CESM)

    Energy Technology Data Exchange (ETDEWEB)

    Gettelman, Andrew [University Corporation For Atmospheric Research (UCAR), Boulder, CO (United States)

    2015-10-01

    In this project we have been upgrading the Multiscale Modeling Framework (MMF) in the Community Atmosphere Model (CAM), also known as Super-Parameterized CAM (SP-CAM). This has included a major effort to update the coding standards and interface with CAM so that it can be placed on the main development trunk. It has also included development of a new software structure for CAM to be able to handle sub-grid column information. These efforts have formed the major thrust of the work.

  4. Toward Realistic Simulation of low-Level Clouds Using a Multiscale Modeling Framework With a Third-Order Turbulence Closure in its Cloud-Resolving Model Component

    Science.gov (United States)

    Xu, Kuan-Man; Cheng, Anning

    2010-01-01

    This study presents preliminary results from a multiscale modeling framework (MMF) with an advanced third-order turbulence closure in its cloud-resolving model (CRM) component. In the original MMF, the Community Atmosphere Model (CAM3.5) is used as the host general circulation model (GCM), and the System for Atmospheric Modeling with a first-order turbulence closure is used as the CRM for representing cloud processes in each grid box of the GCM. The results of annual and seasonal means and diurnal variability are compared between the modified and original MMFs and the CAM3.5. The global distributions of low-level cloud amounts and precipitation and the amounts of low-level clouds in the subtropics and middle-level clouds in mid-latitude storm track regions in the modified MMF show substantial improvement relative to the original MMF when both are compared to observations. Some improvements can also be seen in the diurnal variability of precipitation.

  5. Improvements in the Scalability of the NASA Goddard Multiscale Modeling Framework for Hurricane Climate Studies

    Science.gov (United States)

    Shen, Bo-Wen; Tao, Wei-Kuo; Chern, Jiun-Dar

    2007-01-01

    Improving our understanding of hurricane inter-annual variability and the impact of climate change (e.g., doubling CO2 and/or global warming) on hurricanes brings both scientific and computational challenges to researchers. As hurricane dynamics involves multiscale interactions among synoptic-scale flows, mesoscale vortices, and small-scale cloud motions, an ideal numerical model suitable for hurricane studies should demonstrate its capabilities in simulating these interactions. The newly-developed multiscale modeling framework (MMF, Tao et al., 2007) and the substantial computing power by the NASA Columbia supercomputer show promise in pursuing the related studies, as the MMF inherits the advantages of two NASA state-of-the-art modeling components: the GEOS4/fvGCM and 2D GCEs. This article focuses on the computational issues and proposes a revised methodology to improve the MMF's performance and scalability. It is shown that this prototype implementation enables 12-fold performance improvements with 364 CPUs, thereby making it more feasible to study hurricane climate.

  6. Empowering Cloud Resolving Models Through GPU and Asynchronous IO Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Facilitate use of Goddard Cumulus Ensemble (GCE), Weather Research and Forecasting Model (WRF), and Goddard Multi-scale Modeling Framework (MMF) with bin...

  7. Operation of and prospects for MMF accelerator complex

    Energy Technology Data Exchange (ETDEWEB)

    Kravchuk, L.V. [Institute for Nuclear Research of RAS, 60th October Anniversary pr. 7a, Moscow 117312 (Russian Federation)]. E-mail: kravchuk@inr.ru

    2006-08-15

    Accelerator complex of Moscow Meson Factory (MMF) is presently under operation at Institute for Nuclear Research of the Russian Academy of Sciences. Status and prospects for MMF are briefly described.

  8. Final Technical Report for "High-resolution global modeling of the effects of subgrid-scale clouds and turbulence on precipitating cloud systems"

    Energy Technology Data Exchange (ETDEWEB)

    Larson, Vincent [Univ. of Wisconsin, Milwaukee, WI (United States)

    2016-11-25

    The Multiscale Modeling Framework (MMF) embeds a cloud-resolving model in each grid column of a General Circulation Model (GCM). A MMF model does not need to use a deep convective parameterization, and thereby dispenses with the uncertainties in such parameterizations. However, MMF models grossly under-resolve shallow boundary-layer clouds, and hence those clouds may still benefit from parameterization. In this grant, we successfully created a climate model that embeds a cloud parameterization (“CLUBB”) within a MMF model. This involved interfacing CLUBB’s clouds with microphysics and reducing computational cost. We have evaluated the resulting simulated clouds and precipitation with satellite observations. The chief benefit of the project is to provide a MMF model that has an improved representation of clouds and that provides improved simulations of precipitation.

  9. One-year results with extended-release tacrolimus/MMF, tacrolimus/MMF and cyclosporine/MMF in de novo kidney transplant recipients.

    Science.gov (United States)

    Silva, H T; Yang, H C; Abouljoud, M; Kuo, P C; Wisemandle, K; Bhattacharya, P; Dhadda, S; Holman, J; Fitzsimmons, W; First, M Roy

    2007-03-01

    Once-daily tacrolimus extended-release formulation (Prograf XL, formerly referred to as MR or MR4) was compared with the twice-a-day tacrolimus formulation (TAC) and cyclosporine microemulsion (CsA), all administered in combination with mycophenolate mofetil (MMF), corticosteroids and basiliximab induction, in a phase 3, randomized (1:1:1), open-label trial in 638 de novo kidney transplant recipients. In combination with MMF and corticosteroids, XL had an efficacy profile comparable to TAC and CsA. XL/MMF and TAC/MMF were statistically noninferior at 1-year posttransplantation to CsA/MMF for the primary efficacy endpoint, efficacy failure (death, graft loss, biopsy-confirmed acute rejection (BCAR) or lost to follow-up). One-year patient and graft survival were 98.6% and 96.7% in the XL/MMF group, 95.7% and 92.9% in TAC/MMF group and 97.6% and 95.7% in CsA/MMF group. The safety profile of XL in comparison with CsA was similar to that observed with TAC in this study and consistent with previously published reports of TAC in comparison with CsA. The results support the safety and efficacy of tacrolimus in combination with MMF, corticosteroids and basiliximab induction, as well as XL as a safe and effective once-daily dosing alternative.

  10. Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report.

    Science.gov (United States)

    Kobashigawa, J A; Miller, L W; Russell, S D; Ewald, G A; Zucker, M J; Goldberg, L R; Eisen, H J; Salm, K; Tolzman, D; Gao, J; Fitzsimmons, W; First, R

    2006-06-01

    The most advantageous combination of immunosuppressive agents for cardiac transplant recipients has not yet been established. Between November 2001 and June 2003, 343 de novo cardiac transplant recipients were randomized to receive steroids and either tacrolimus (TAC) + sirolimus (SRL), TAC + mycophenolate mofetil (MMF) or cyclosporine (CYA) + MMF. Antilymphocyte induction therapy was allowed for up to 5 days. The primary endpoint of >/=3A rejection or hemodynamic compromise rejection requiring treatment showed no significant difference at 6 months (TAC/MMF 22.4%, TAC/SRL 24.3%, CYA/MMF 31.6%, p = 0.271) and 1 year (p = 0.056), but it was significantly lower in the TAC/MMF group when compared only to the CYA/MMF group at 1 year (23.4% vs. 36.8%; p = 0.029). Differences in the incidence of any treated rejection were significant (TAC/SRL = 35%, TAC/MMF = 42%, CYA/MMF = 59%; p MMF = 1.3 mg/dL, CYA/MMF = 1.5 mg/dL; p = 0.032) and triglycerides (TAC/SRL = 162 mg/dL, TAC/MMF = 126 mg/dL, CYA/MMF = 154 mg/dL; p = 0.028). The TAC/SRL group encountered fewer viral infections but more fungal infections and impaired wound healing. These secondary endpoints suggest that the TAC/MMF combination appears to offer more advantages than TAC/SRL or CYA/MMF in cardiac transplant patients, including fewer >/=3A rejections or hemodynamic compromise rejections and an improved side-effect profile.

  11. Performance of the Goddard multiscale modeling framework with Goddard ice microphysical schemes

    Science.gov (United States)

    Chern, Jiun-Dar; Tao, Wei-Kuo; Lang, Stephen E.; Matsui, Toshihisa; Li, J.-L. F.; Mohr, Karen I.; Skofronick-Jackson, Gail M.; Peters-Lidard, Christa D.

    2016-03-01

    The multiscale modeling framework (MMF), which replaces traditional cloud parameterizations with cloud-resolving models (CRMs) within a host atmospheric general circulation model (GCM), has become a new approach for climate modeling. The embedded CRMs make it possible to apply CRM-based cloud microphysics directly within a GCM. However, most such schemes have never been tested in a global environment for long-term climate simulation. The benefits of using an MMF to evaluate rigorously and improve microphysics schemes are here demonstrated. Four one-moment microphysical schemes are implemented into the Goddard MMF and their results validated against three CloudSat/CALIPSO cloud ice products and other satellite data. The new four-class (cloud ice, snow, graupel, and frozen drops/hail) ice scheme produces a better overall spatial distribution of cloud ice amount, total cloud fractions, net radiation, and total cloud radiative forcing than earlier three-class ice schemes, with biases within the observational uncertainties. Sensitivity experiments are conducted to examine the impact of recently upgraded microphysical processes on global hydrometeor distributions. Five processes dominate the global distributions of cloud ice and snow amount in long-term simulations: (1) allowing for ice supersaturation in the saturation adjustment, (2) three additional correction terms in the depositional growth of cloud ice to snow, (3) accounting for cloud ice fall speeds, (4) limiting cloud ice particle size, and (5) new size-mapping schemes for snow and graupel. Despite the cloud microphysics improvements, systematic errors associated with subgrid processes, cyclic lateral boundaries in the embedded CRMs, and momentum transport remain and will require future improvement.

  12. Performance of the Goddard Multiscale Modeling Framework with Goddard Ice Microphysical Schemes

    Science.gov (United States)

    Chern, Jiun-Dar; Tao, Wei-Kuo; Lang, Stephen E.; Matsui, Toshihisa; Li, J.-L.; Mohr, Karen I.; Skofronick-Jackson, Gail M.; Peters-Lidard, Christa D.

    2016-01-01

    The multiscale modeling framework (MMF), which replaces traditional cloud parameterizations with cloud-resolving models (CRMs) within a host atmospheric general circulation model (GCM), has become a new approach for climate modeling. The embedded CRMs make it possible to apply CRM-based cloud microphysics directly within a GCM. However, most such schemes have never been tested in a global environment for long-term climate simulation. The benefits of using an MMF to evaluate rigorously and improve microphysics schemes are here demonstrated. Four one-moment microphysical schemes are implemented into the Goddard MMF and their results validated against three CloudSat/CALIPSO cloud ice products and other satellite data. The new four-class (cloud ice, snow, graupel, and frozen drops/hail) ice scheme produces a better overall spatial distribution of cloud ice amount, total cloud fractions, net radiation, and total cloud radiative forcing than earlier three-class ice schemes, with biases within the observational uncertainties. Sensitivity experiments are conducted to examine the impact of recently upgraded microphysical processes on global hydrometeor distributions. Five processes dominate the global distributions of cloud ice and snow amount in long-term simulations: (1) allowing for ice supersaturation in the saturation adjustment, (2) three additional correction terms in the depositional growth of cloud ice to snow, (3) accounting for cloud ice fall speeds, (4) limiting cloud ice particle size, and (5) new size-mapping schemes for snow and graupel. Despite the cloud microphysics improvements, systematic errors associated with subgrid processes, cyclic lateral boundaries in the embedded CRMs, and momentum transport remain and will require future improvement.

  13. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...... are generated through the template in ICAS-MoT and translated into a model object. Once in ICAS-MoT, the model is numerical analyzed, solved and identified. A computer-aided modeling framework integrating systematic model derivation and development tools has been developed. It includes features for model...

  14. Dicyanometallates as Model Extended Frameworks

    Science.gov (United States)

    2016-01-01

    We report the structures of eight new dicyanometallate frameworks containing molecular extra-framework cations. These systems include a number of hybrid inorganic–organic analogues of conventional ceramics, such as Ruddlesden–Popper phases and perovskites. The structure types adopted are rationalized in the broader context of all known dicyanometallate framework structures. We show that the structural diversity of this family can be understood in terms of (i) the charge and coordination preferences of the particular metal cation acting as framework node, and (ii) the size, shape, and extent of incorporation of extra-framework cations. In this way, we suggest that dicyanometallates form a particularly attractive model family of extended frameworks in which to explore the interplay between molecular degrees of freedom, framework topology, and supramolecular interactions. PMID:27057759

  15. Geologic Framework Model (GFM2000)

    Energy Technology Data Exchange (ETDEWEB)

    T. Vogt

    2004-08-26

    The purpose of this report is to document the geologic framework model, version GFM2000 with regard to input data, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, and the differences between GFM2000 and previous versions. The version number of this model reflects the year during which the model was constructed. This model supersedes the previous model version, documented in Geologic Framework Model (GFM 3.1) (CRWMS M&O 2000 [DIRS 138860]). The geologic framework model represents a three-dimensional interpretation of the geology surrounding the location of the monitored geologic repository for spent nuclear fuel and high-level radioactive waste at Yucca Mountain. The geologic framework model encompasses and is limited to an area of 65 square miles (168 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the geologic framework model (shown in Figure 1-1) were chosen to encompass the exploratory boreholes and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The upper surface of the model is made up of the surface topography and the depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The geologic framework model was constructed from geologic map and borehole data. Additional information from measured stratigraphic sections, gravity profiles, and seismic profiles was also considered. The intended use of the geologic framework model is to provide a geologic framework over the area of interest consistent with the level of detailed needed for hydrologic flow and radionuclide transport modeling through the UZ and for repository design. The model is limited by the availability of data and relative amount of geologic complexity found in an area. The geologic framework model is inherently limited by scale and content. The grid spacing used in the

  16. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    with them. As the required models may be complex and require multiple time and/or length scales, their development and application for product-process design is not trivial. Therefore, a systematic modeling framework can contribute by significantly reducing the time and resources needed for model...... development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...

  17. Environmental modeling framework invasiveness: analysis and implications

    Science.gov (United States)

    Environmental modeling frameworks support scientific model development by providing an Application Programming Interface (API) which model developers use to implement models. This paper presents results of an investigation on the framework invasiveness of environmental modeling frameworks. Invasiven...

  18. A Model for Rearchitecting Frameworks

    Directory of Open Access Journals (Sweden)

    Galal H. Galal-Edeen

    2009-07-01

    Full Text Available Software rearchitecting is the process of obtaining a documented architecture for an existing system. There are many software rearchitecting frameworks which are based upon different concepts and context-related issues for a specific application or programming language, such as Rigi, Ciao, SPOOL, and Symphony, and Software Rearchitecting Action Framework (SRAF. Most of the frameworks focus on the reverse engineering process of source code. They neglect the role of stakeholders in enhancing and developing their systems. This paper presents a systematic analysis and comparative study for rearchitecting frameworks using generic architecture characteristics or elements. Based on the major requirements that should be available in the rearchitecting frameworks, the comparative study proceeds. An efficient model is proposed based on the trends that resulted from the comparative analysis. It considers the evaluation criteria of the compared frameworks. Conclusions and remarks are highlighted.

  19. [Case of MMF monotherapy for membranous nephropathy].

    Science.gov (United States)

    Kobayashi, Mioko; Kojima, Chiari; Sugiura, Hidekazu; Aoki, Asuka; Itabashi, Mitsuyo; Tsukada, Misao; Takei, Takashi; Uchida, Keiko; Nitta, Kosaku

    2010-01-01

    We report the case of a 58-year-old male patient who visited our hospital for the management of edema and proteinuria. He was diagnosed as having nephrotic syndrome, with serum total protein and albumin levels of 4.6 g/dL and 2.1 g/dL, respectively, and a urinary protein excretion level of 6.0 g/day. A percutaneous renal biopsy showed features of membranous glomerulonephritis, with capillary-wall granular deposits of IgG and C3 on immunofluorescence and subepithelial immune complex deposits on electron microscopy. No other secondary cause of membranous glomerulopathy was found even after extensive investigations. The patient was started on mycophenolate mofetil (MMF) monotherapy (1,500 mg/day), and 18 months after the start of this therapy, the proteinuria decreased to 0.5 g/day, with return to a normal serum albumin level. No digestive symptoms, kidney function worsening or increase in blood pressure were noted during treatment. These findings suggest that MMF monotherapy is effective and safe for the treatment of membranous nephropathy.

  20. Mycophenolate Mofetil (MMF) Efficacy in Glomerulonephritis (GN), a Retrospective Analysis.

    Science.gov (United States)

    Huraib, Sameer O; Qureshi, Junaid I; Quadri, Khaja Hm; Al Flaiw, Ahmed; Al Ghamdi, Ghormullah; Jumani, Abdulqadir; Al Hejaili, Fayez; Raza, Hammad; Al Johani, Abdulaziz; Al-Katheri, Abdulmalik; Al-Khader, Abdullah A

    2005-01-01

    Mycophenolate Mofetil MMF has been widely used in post-transplant immunosuppression. Its role is emerging in GN. MMF demonstrated promising results compared with cyclosphosphamide in stage IV lupus nephritis, in a recently published trial. It has been found to have a wide safety profile, with mostly gastroinetestinal side effects, which can be avoided through titration. Its action is through inhibition of the enzyme IMDPH (ionosine monophosphate dehydrogenase), leading to purine antagonism and inhibition of lymphocytes. We were aiming to demonstrate the efficacy of MMF in our GN population. In this study, we reviewed 17 patients who received MMF (dose - 1 gm po bid) for the past year. They were only included if it was given for the management of resistant primary glomerulonephritis. Complete remission has been defined as proteinuria of less than 0.5 g/day and partial remission as a reduction of proteinuria 50% of starting MMF therapy; all 17 MMF therapy patients uniformly achieved good BP ((29%) achieved complete remission and this group consisted of 1 membranous GN, 2 lupus GN (type IV and membranous), one FSGS and one with MPGN. Four of 17 (23%) were non-responders to therapy. This group articles.aspx? id=41 to side effects. We conclude that the MMF appears to be an effective alternate treatment modality in resistant membranous GN, lupus nephritis (type IV and V) and possibly MPGN, and to a lesser extent in resistant FSGS. Further prospective data may demonstrate the efficacy of MMF in GN.

  1. AZA/tacrolimus is associated with similar outcomes as MMF/tacrolimus among renal transplant recipients.

    Science.gov (United States)

    Schold, J D; Kaplan, B

    2009-09-01

    There have been several retrospective studies indicating benefits associated with mycophenalate mofetil (MMF) compared to azathioprine (AZA) for renal transplant recipients. However, these analyses evaluated outcomes prior to changes in utilization patterns of concomitant immunosuppression. Recent prospective trials have indicated similar outcomes among patients treated with MMF and AZA. The aim of this study was to evaluate outcomes in a broad group of patients in the more recent era. We evaluated adult solitary renal transplant recipients from 1998 to 2006 with the national SRTR database. Primary outcomes were time to patient death and graft loss, complications and renal function. Models were adjusted for potential confounding factors, propensity scores and stratified between higher/lower risk transplants and concomitant immunosuppression. Adjusted models indicated a modest risk among AZA patients for graft loss (AHR = 1.14, 95% CI 1.07-1.20); however, this was not apparent among AZA patients also treated with tacrolimus (AHR = 0.97, 95% CI 0.85-1.11]. One-year acute rejection rates were reduced for patients on MMF versus AZA (10 vs. 13%, p MMF with improved outcomes may not be apparent in patients also receiving tacrolimus.

  2. CMAQ Model Evaluation Framework

    Science.gov (United States)

    CMAQ is tested to establish the modeling system’s credibility in predicting pollutants such as ozone and particulate matter. Evaluation of CMAQ has been designed to assess the model’s performance for specific time periods and for specific uses.

  3. Combined MMF and insulin therapy prevents renal injury in experimental diabetic rats.

    Science.gov (United States)

    Wu, Xiaoyan; Zha, Dongqing; Xiang, Guangsheng; Zhang, Bo; Xiao, Shu-Yuan; Jia, Ruhan

    2006-12-01

    Conventional therapies for diabetic mellitus are not effective in preventing the progression from early diabetic nephropathy (DN) to end-stage renal disease. The role of inflammation in the pathogenesis of DN has been implicated both clinically and experimentally, which provides an alternative therapeutic target for DN. Anti-inflammatory impact of mycophenolate mofetil (MMF) alone and in combination with insulin had been observed in a rat model of experimental DN. In this study, the diabetic rats were subjected to different treatments. Compared to control, the expression levels of CD68, NGF, and NF-kappaB p65, as determined immunohistochemically, were elevated in diabetic rats. Treatment with combined MMF/insulin is associated with a significant reduction in renal tissue of NGF and NF-kappaB p65 expression, macrophage infiltration. It also partially improved the renal function and attenuated renal hypertrophy at early stage of DN. CD68 was found to positively correlate with urinary albumin excretion and NGF. The combined use of MMF/insulin seemed to offer more protections in rats with experimental diabetic renal injury, and the protective effects of MMF might be due to its anti-inflammatory actions through inhibition of NF-kappaB activation and reduction of T cells and macrophage infiltration and/or other kidney chemokine productions.

  4. Evaluation of the MMF (Morgan-Morgan-Finney) model based on soil loss experimental data from vineyards in Alto Monferrato area (NW Italy)

    Science.gov (United States)

    Biddoccu, Marcella; Cavallo, Eugenio

    2010-05-01

    hydraulic conductivity are available for each plot. They have been used, besides to climate data and land cover guide values, as input parameter in the modified Morgan-Morgan-Finney model (Morgan & Duzant, 2008), specifically elaborated to evaluate effects of crops and vegetation on soil erosion. The model output has been compared with experimental data, in order to validate the model performance. Expected annual soil loss calculated for each plot is consistent with the mean value obtained in the period of observation.

  5. Uncommon side effect of MMF in renal transplant recipients.

    Science.gov (United States)

    Balal, M; Demir, E; Paydas, Saime; Sertdemir, Y; Erken, U

    2005-01-01

    Mycophenolate mofetil (MMF) is a potent immunosuppressive agent used in renal transplantation. Gastrointestinal and hematological side effects are commonly observed, but hepatotoxicity has not been reported. In this study, we assessed MMF-related hepatotoxicity in renal transplant recipients. A total of 124 renal transplantation recipients (RTRs) were evaluated for elevated liver enzymes associated with MMF, and 79 patients were enrolled to the study. Patients used MMF 2 g/day. The patients who had progressive increase in liver enzymes after renal transplantation and their AST, ALT, GGT, ALP, bilirubin levels, hepatitis, cytomegalovirus (CMV), abdominal ultrasonography, duration of hepatotoxicity, and decreased dosage or withdrawal of MMF were recorded. Also, we evaluated their liver enzymes while the patients were on the waiting list. Of the 79 patients, 11 patients (13.9%) had a progressive increase in liver enzymes. The median (min-max) age of the patients with MMF-hepatotoxicity was 29 (19-54) and 72.7% of them were male. None of the patients had hepatitis B or C, CMV infection, or other possible causes for elevated liver enzymes and their abdominal ultrasonography were normal. High liver enzyme levels regressed after the withdrawal (n=6) or reduce dosage (n=5) of MMF. The median time of the increase in liver enzymes was 28 (4-70) days and after 50% reduction or withdrawal of MMF, returned to normal values in 16 (4-210) days. The median levels of ALT in waiting list (I), before (II), and after (III) reduction dosage or withdrawal of MMF were 22.0 (3-22), 222.0 (51-508), and 33.0 (21-64) U/L, respectively (p I-II=0.004,p I-II=0.013, andp II-III=0.005). There were no differences for ALP, GGT, total bilirubin, and direct bilirubin levels. Also, the correlation between recovery time of ALT and persistence time of ALT elevation before adjustment of MMF was significant (r=0.739, p=0.009). Consequently, after renal transplantation, hepatotoxicity can occur due to a

  6. Land-Atmosphere Coupling in the Multi-Scale Modelling Framework

    Science.gov (United States)

    Kraus, P. M.; Denning, S.

    2015-12-01

    The Multi-Scale Modeling Framework (MMF), in which cloud-resolving models (CRMs) are embedded within general circulation model (GCM) gridcells to serve as the model's cloud parameterization, has offered a number of benefits to GCM simulations. The coupling of these cloud-resolving models directly to land surface model instances, rather than passing averaged atmospheric variables to a single instance of a land surface model, the logical next step in model development, has recently been accomplished. This new configuration offers conspicuous improvements to estimates of precipitation and canopy through-fall, but overall the model exhibits warm surface temperature biases and low productivity.This work presents modifications to a land-surface model that take advantage of the new multi-scale modeling framework, and accommodate the change in spatial scale from a typical GCM range of ~200 km to the CRM grid-scale of 4 km.A parameterization is introduced to apportion modeled surface radiation into direct-beam and diffuse components. The diffuse component is then distributed among the land-surface model instances within each GCM cell domain. This substantially reduces the number excessively low light values provided to the land-surface model when cloudy conditions are modeled in the CRM, associated with its 1-D radiation scheme. The small spatial scale of the CRM, ~4 km, as compared with the typical ~200 km GCM scale, provides much more realistic estimates of precipitation intensity, this permits the elimination of a model parameterization of canopy through-fall. However, runoff at such scales can no longer be considered as an immediate flow to the ocean. Allowing sub-surface water flow between land-surface instances within the GCM domain affords better realism and also reduces temperature and productivity biases.The MMF affords a number of opportunities to land-surface modelers, providing both the advantages of direct simulation at the 4 km scale and a much reduced

  7. A Unified Framework for Systematic Model Improvement

    DEFF Research Database (Denmark)

    Kristensen, Niels Rode; Madsen, Henrik; Jørgensen, Sten Bay

    2003-01-01

    A unified framework for improving the quality of continuous time models of dynamic systems based on experimental data is presented. The framework is based on an interplay between stochastic differential equation (SDE) modelling, statistical tests and multivariate nonparametric regression...

  8. 基于使命和方法框架的武器装备体系结构建模%Stracture Modeling of Weapon Equipment System of Systems Based on Missions and Means Framework

    Institute of Scientific and Technical Information of China (English)

    叶国青; 舒宇; 葛冰峰; 陈英武

    2012-01-01

    针对武器装备体系的特点,提出一种基于使命和方法框架(Missions and Means Framework,MMF)的武器装备体系结构建模方法.MMF模型包含使命的确定、方法的分配和使命完成的评价.采用使命-方法框架对武器装备体系进行组织和描述.在自上而下的规划和决策过程中,实现了使命的确定和方法的分配,以数据要素的形式完成对武器装备体系结构模型的构建.并以"超地平线登陆"作战装备体系为例,验证了该方法的可行性.%To model the stracture of weapon equipment system-of-systems (WESoS), a new method based on the mission and means framework (MMF) is presented according to its characteristics. The MMF model comprises the specification of the mission. allocation of the means and assessment of the mission accomplishment. Using the MMF to organize and describe the WESoS, It addresses the structure modeling of the WESoS as a top-down planning and decision making process that accomplishes the specification of the missions and the allocation of the means in data element form. The case study of the over-the-horizon landing WESoS demonstrates the feasibility of the method.

  9. Crystallization Kinetics within a Generic Modelling Framework

    DEFF Research Database (Denmark)

    Meisler, Kresten Troelstrup; von Solms, Nicolas; Gernaey, Krist

    2013-01-01

    An existing generic modelling framework has been expanded with tools for kinetic model analysis. The analysis of kinetics is carried out within the framework where kinetic constitutive models are collected, analysed and utilized for the simulation of crystallization operations. A modelling...... procedure is proposed to gain the information of crystallization operation kinetic model analysis and utilize this for faster evaluation of crystallization operations....

  10. Geologic Framework Model Analysis Model Report

    Energy Technology Data Exchange (ETDEWEB)

    R. Clayton

    2000-12-19

    The purpose of this report is to document the Geologic Framework Model (GFM), Version 3.1 (GFM3.1) with regard to data input, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, qualification status of the model, and the differences between Version 3.1 and previous versions. The GFM represents a three-dimensional interpretation of the stratigraphy and structural features of the location of the potential Yucca Mountain radioactive waste repository. The GFM encompasses an area of 65 square miles (170 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the GFM were chosen to encompass the most widely distributed set of exploratory boreholes (the Water Table or WT series) and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The GFM was constructed from geologic map and borehole data. Additional information from measured stratigraphy sections, gravity profiles, and seismic profiles was also considered. This interim change notice (ICN) was prepared in accordance with the Technical Work Plan for the Integrated Site Model Process Model Report Revision 01 (CRWMS M&O 2000). The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The GFM is one component of the Integrated Site Model (ISM) (Figure l), which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1) Geologic Framework Model (GFM); (2) Rock Properties Model (RPM); and (3) Mineralogic Model (MM). The ISM merges the detailed project stratigraphy into model stratigraphic units that are most useful for the primary downstream models and the

  11. Reach Extension and Capacity Enhancement of VCSEL-Based Transmission Over Single-Lane MMF Links

    DEFF Research Database (Denmark)

    Tatarczak, Anna; Motaghiannezam, S. M. Reza; Kocot, Chris

    2017-01-01

    This paper reviews and examines several techniques for expanding the carrying capacity of multimode fiber (MMF) using vertical cavity surface emitting lasers (VCSELs). The first approach utilizes short wavelength division multiplexing in combination with MMF optimized for operation between 850...

  12. Deriving Framework Usages Based on Behavioral Models

    Science.gov (United States)

    Zenmyo, Teruyoshi; Kobayashi, Takashi; Saeki, Motoshi

    One of the critical issue in framework-based software development is a huge introduction cost caused by technical gap between developers and users of frameworks. This paper proposes a technique for deriving framework usages to implement a given requirements specification. By using the derived usages, the users can use the frameworks without understanding the framework in detail. Requirements specifications which describe definite behavioral requirements cannot be related to frameworks in as-is since the frameworks do not have definite control structure so that the users can customize them to suit given requirements specifications. To cope with this issue, a new technique based on satisfiability problems (SAT) is employed to derive the control structures of the framework model. In the proposed technique, requirements specifications and frameworks are modeled based on Labeled Transition Systems (LTSs) with branch conditions represented by predicates. Truth assignments of the branch conditions in the framework models are not given initially for representing the customizable control structure. The derivation of truth assignments of the branch conditions is regarded as the SAT by assuming relations between termination states of the requirements specification model and ones of the framework model. This derivation technique is incorporated into a technique we have proposed previously for relating actions of requirements specifications to ones of frameworks. Furthermore, this paper discuss a case study of typical use cases in e-commerce systems.

  13. Frameworks for understanding and describing business models

    DEFF Research Database (Denmark)

    Nielsen, Christian; Roslender, Robin

    2014-01-01

    This chapter provides in a chronological fashion an introduction to six frameworks that one can apply to describing, understanding and also potentially innovating business models. These six frameworks have been chosen carefully as they represent six very different perspectives on business models ...... Maps (2001) • Intellectual Capital Statements (2003) • Chesbrough’s framework for Open Business Models (2006) • Business Model Canvas (2008)......This chapter provides in a chronological fashion an introduction to six frameworks that one can apply to describing, understanding and also potentially innovating business models. These six frameworks have been chosen carefully as they represent six very different perspectives on business models...... and in this manner “complement” each other. There are a multitude of varying frameworks that could be chosen from and we urge the reader to search and trial these for themselves. The six chosen models (year of release in parenthesis) are: • Service-Profit Chain (1994) • Strategic Systems Auditing (1997) • Strategy...

  14. A UML profile for framework modeling

    Institute of Scientific and Technical Information of China (English)

    XU Xiao-liang(徐小良); WANG Le-yu(汪乐宇); ZHOU Hong(周泓)

    2004-01-01

    The current standard Unified Modeling Language(UML) could not model framework flexibility and extendibility adequately due to lack of appropriate constructs to distinguish framework hot-spots from kernel elements. A new UML profile that may customize UML for framework modeling was presented using the extension mechanisms of UML, providing a group of UML extensions to meet the needs of framework modeling. In this profile, the extended class diagrams and sequence diagrams were defined to straightforwardly identify the hot-spots and describe their instantiation restrictions. A transformation model based on design patterns was also put forward, such that the profile based framework design diagrams could be automatically mapped to the corresponding implementation diagrams. It was proved that the presented profile makes framework modeling more straightforwardly and therefore easier to understand and instantiate.

  15. A UML profile for framework modeling.

    Science.gov (United States)

    Xu, Xiao-liang; Wang, Le-yu; Zhou, Hong

    2004-01-01

    The current standard Unified Modeling Language(UML) could not model framework flexibility and extendability adequately due to lack of appropriate constructs to distinguish framework hot-spots from kernel elements. A new UML profile that may customize UML for framework modeling was presented using the extension mechanisms of UML, providing a group of UML extensions to meet the needs of framework modeling. In this profile, the extended class diagrams and sequence diagrams were defined to straightforwardly identify the hot-spots and describe their instantiation restrictions. A transformation model based on design patterns was also put forward, such that the profile based framework design diagrams could be automatically mapped to the corresponding implementation diagrams. It was proved that the presented profile makes framework modeling more straightforwardly and therefore easier to understand and instantiate.

  16. A framework for sustainable interorganizational business model

    OpenAIRE

    Neupane, Ganesh Prasad; Haugland, Sven A.

    2016-01-01

    Drawing on literature on business model innovations and sustainability, this paper develops a framework for sustainable interorganizational business models. The aim of the framework is to enhance the sustainability of firms’ business models by enabling firms to create future value by taking into account environmental, social and economic factors. The paper discusses two themes: (1) application of the term sustainability to business model innovation, and (2) implications of integrating sustain...

  17. Beam forming system modernization at the MMF linac proton injector

    CERN Document Server

    Derbilov, V I; Nikulin, E S; Frolov, O T

    2001-01-01

    The isolation improvements of the beam forming system (BFS) of the MMF linac proton injector ion source are reported. The mean beam current and,accordingly, BFS electrode heating were increased when the MMF linac has began to operate regularly in long beam sessions with 50 Hz pulse repetition rate. That is why the BFS electrode high-voltage isolation that was made previously as two consequently and rigidly glued solid cylinder insulators has lost mechanical and electric durability. The substitution of large (160 mm) diameter cylinder insulator for four small diameter (20 mm) tubular rods has improved vacuum conditions in the space of beam forming and has allowed to operate without failures when beam currents being up to 250 mA and extraction and focusing voltage being up to 25 and 40 kV respectively. Moreover,the construction provides the opportunity of electrode axial move. The insulators are free from electrode thermal expansion mechanical efforts in a transverse direction.

  18. Crystallization Kinetics within a Generic Modeling Framework

    DEFF Research Database (Denmark)

    Meisler, Kresten Troelstrup; von Solms, Nicolas; Gernaey, Krist V.

    2014-01-01

    to the modeling of various kinetic phenomena like nucleation, growth, agglomeration, and breakage are discussed in terms of model forms, model parameters, their availability and/or estimation, and their selection and application for specific crystallization operational scenarios under study. The advantages......A new and extended version of a generic modeling framework for analysis and design of crystallization operations is presented. The new features of this framework are described, with focus on development, implementation, identification, and analysis of crystallization kinetic models. Issues related...... of employing a well-structured model library for storage, use/reuse, and analysis of the kinetic models are highlighted. Examples illustrating the application of the modeling framework for kinetic model discrimination related to simulation of specific crystallization scenarios and for kinetic model parameter...

  19. PHARMACOKINETIC AND PHARMACODYNAMIC ANALYSIS OF INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) ACTIVITY IN MMF-TREATED HCT RECIPIENTS

    Science.gov (United States)

    Li, Hong; Mager, Donald E.; Sandmaier, Brenda M.; Storer, Barry E.; Boeckh, Michael J.; Bemer, Meagan J.; Phillips, Brian R.; Risler, Linda J.; McCune, Jeannine S.

    2014-01-01

    A novel approach to personalizing postgrafting immunosuppression in hematopoietic cell transplant (HCT) recipients is evaluating inosine monophosphate dehydrogenase (IMPDH) activity as a drug-specific biomarker of mycophenolic acid (MPA)-induced immunosuppression. This prospective study evaluated total MPA, unbound MPA, and total MPA glucuronide plasma concentrations and IMPDH activity in peripheral blood mononuclear cells (PMNC) at five time points after the morning dose of oral mycophenolate mofetil (MMF) on day +21 in 56 nonmyeloablative HCT recipients. Substantial interpatient variability in the pharmacokinetics and pharmacodynamics was observed and accurately characterized by the population pharmacokinetic/dynamic model. IMPDH activity decreased with increasing MPA plasma concentration, with maximum inhibition coinciding with maximum MPA concentration in most patients. The overall relationship between MPA concentration and IMPDH activity was described by a direct inhibitory Emax model with an IC50 = 3.23 mg/L total MPA and 57.3 ng/mL unbound MPA. The day +21 IMPDH area under the effect curve (AUEC) was associated with cytomegalovirus reactivation, non-relapse mortality, and overall mortality. In conclusion, a pharmacokinetic/dynamic model was developed that relates plasma MPA concentrations with PMNC IMPDH activity after an MMF dose in HCT recipients. Future studies should validate this model and confirm that day +21 IMPDH AUEC is a predictive biomarker. PMID:24727337

  20. Impact of mycophenolate mofetil (MMF)-related gastrointestinal complications and MMF dose alterations on transplant outcomes and healthcare costs in renal transplant recipients.

    Science.gov (United States)

    Tierce, J C; Porterfield-Baxa, J; Petrilla, A A; Kilburg, A; Ferguson, R M

    2005-12-01

    Mycophenolate mofetil (MMF), a mycophenolic acid prodrug, is a highly effective adjunct immunosuppressive agent in transplant therapy. Although MMF is generally well tolerated, optimal therapy may be limited by adverse effects, in particular gastrointestinal (GI) toxicity, which has been reported to occur in up to 45% of MMF-treated patients. MMF dose changes resulting from these adverse events may lead to sub-therapeutic dosing and impaired clinical outcomes. This retrospective study analyzed clinical records from 772 renal transplant patients from 10 US transplant centers who were initiated on MMF. The analysis revealed that 49.7% (n = 382) of patients experienced at least one GI complication within the first 6 months post-transplant, with 66.8% (n = 255) of these having multiple GI complications. Of the patients with GI complications, 39.0% experienced MMF dose adjustments or discontinuation of MMF therapy. Patients with GI complications who experienced MMF dose adjustments/discontinuation had a significantly increased incidence of acute rejections compared with patients without GI complications (30.2% vs. 19.4%; p = 0.005). Mean treatment costs were higher in patients with GI complications than in those with no GI complications, particularly in those who experienced MMF dose adjustments/discontinuation (p = 0.0001). The mean incremental cost for patients experiencing GI complications was US$3700 per patient during the 6 months post-transplant (p MMF dose adjustments/discontinuations are associated with a significant negative impact on transplant outcomes and markedly increase short-term treatment costs.

  1. MDM: A Mode Diagram Modeling Framework

    DEFF Research Database (Denmark)

    Wang, Zheng; Pu, Geguang; Li, Jianwen

    2012-01-01

    systems are widely used in the above-mentioned safety-critical embedded domains, there is lack of domain-specific formal modelling languages for such systems in the relevant industry. To address this problem, we propose a formal visual modeling framework called mode diagram as a concise and precise way...... checking technique can then be used to verify the mode diagram models against desired properties. To demonstrate the viability of our approach, we have applied our modelling framework to some real life case studies from industry and helped detect two design defects for some spacecraft control systems....

  2. Graphical Model Debugger Framework for Embedded Systems

    DEFF Research Database (Denmark)

    Zeng, Kebin

    2010-01-01

    Debugger Framework, providing an auxiliary avenue of analysis of system models at runtime by executing generated code and updating models synchronously, which allows embedded developers to focus on the model level. With the model debugger, embedded developers can graphically test their design model......Model Driven Software Development has offered a faster way to design and implement embedded real-time software by moving the design to a model level, and by transforming models to code. However, the testing of embedded systems has remained at the code level. This paper presents a Graphical Model...... and check the running status of the system, which offers a debugging capability on a higher level of abstraction. The framework intends to contribute a tool to the Eclipse society, especially suitable for model-driven development of embedded systems....

  3. MMF and calcineurin taper in recurrent hepatitis C after liver transplantation: impact on histological course.

    Science.gov (United States)

    Bahra, Marcus; Neumann, U I F P; Jacob, Dietmar; Puhl, Gero; Klupp, Jochen; Langrehr, Jan M; Berg, Thomas; Neuhaus, Peter

    2005-02-01

    Hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (OLT) is almost universal. The optimal immunosuppression for these patients is still under discussion. We designed a retrospective case-control study to evaluate the effect of mycophenolate mofetil (MMF) treatment in patients with recurrent hepatitis C. Forty patients with histologically proven hepatitis C recurrence after OLT were treated with MMF and calcineurin inhibitor (CNI) taper for 24 months and matched with 40 non-MMF-treated positive liver transplant recipients. Liver biopsies were obtained prior to MMF treatment and after a mean follow-up of 24 months. Histological changes were evaluated utilizing the Metavir score. Comparison of fibrosis/inflammation showed no impairment of histological findings during MMF treatment. In contrast, histological findings of the 40 non-MMF patients showed a significant increase of severity for inflammation/fibrosis. Viral load was similar in both groups. The course of alanin amino transferase (ALT) levels measured during MMF treatment showed a significant decrease. MMF in combination with CNI taper showed a positive effect on fibrosis progression, graft inflammation and ALT levels and may improve the clinical course of HCV after OLT, however, the antiviral properties of MMF are still unconfirmed.

  4. An explicit representation of vertical momentum transport in a multiscale modeling framework through its 2-D cloud-resolving model component

    Science.gov (United States)

    Cheng, Anning; Xu, Kuan-Man

    2014-03-01

    In this study, an explicit representation of vertical momentum transport by convective cloud systems, including mesoscale convective systems (MCSs), is proposed and tested in a multiscale modeling framework (MMF). The embedded cloud-resolving model (CRM) provides vertical momentum transport in one horizontal direction. The vertical momentum transport in the other direction is assumed to be proportional to the vertical mass flux diagnosed from the CRM in addition to the effects of entrainment and detrainment. In order to represent both upgradient and downgradient vertical momentum transports, the orientation of the embedded CRM must change with time instead of being stationary typically in MMFs. The orientation is determined by the stratification of the lower troposphere and environmental wind shear. Introducing the variation of the orientations of the embedded CRM is responsible for reducing the stationary anomalous precipitation and many improvements. Improvements are strengthened when the CRM simulated vertical momentum transport is allowed to modify the large-scale circulation simulated by the host general circulation model. These include an improved spatial distribution, amplitude, and intraseasonal variability of the surface precipitation in the tropics, more realistic zonal mean diabatic heating and drying patterns, more reasonable zonal mean large-scale circulations and the East Asian summer monsoon circulation, and an improved, annual mean implied meridional ocean transport in the Southern Hemisphere. Further tests of this convective momentum transport parameterization scheme will be performed with a higher-resolution MMF to further understand its roles in the intraseasonal oscillation and tropical waves, monsoon circulation, and zonal mean large-scale circulations.

  5. Graphical Model Debugger Framework for Embedded Systems

    DEFF Research Database (Denmark)

    Zeng, Kebin; Guo, Yu; Angelov, Christo K.

    2010-01-01

    Model Driven Software Development has offered a faster way to design and implement embedded real-time software by moving the design to a model level, and by transforming models to code. However, the testing of embedded systems has remained at the code level. This paper presents a Graphical Model...... Debugger Framework, providing an auxiliary avenue of analysis of system models at runtime by executing generated code and updating models synchronously, which allows embedded developers to focus on the model level. With the model debugger, embedded developers can graphically test their design model...

  6. Should we consider MMF therapy after rituximab for nephrotic syndrome?

    Science.gov (United States)

    Filler, Guido; Huang, Shih-Han Susan; Sharma, Ajay P

    2011-10-01

    The management of steroid-dependent nephrotic syndrome, especially in patients who have failed to respond to cytotoxic drugs, such as cyclophosphamide, remains challenging. Rituximab represents a new (off-label) therapeutic option. In a significant portion of patients, it has a short serum half-life following the recovery of CD20-positive cells. The addition of mycophenolate mofetil (MMF) as a maintenance therapy is also an attractive option, but one which requires testing in a prospective randomized clinical trial with therapeutic drug monitoring and mechanistic ancillary studies.

  7. A Framework for Modelling Software Requirements

    Directory of Open Access Journals (Sweden)

    Dhirendra Pandey

    2011-05-01

    Full Text Available Requirement engineering plays an important role in producing quality software products. In recent past years, some approaches of requirement framework have been designed to provide an end-to-end solution for system development life cycle. Textual requirements specifications are difficult to learn, design, understand, review, and maintain whereas pictorial modelling is widely recognized as an effective requirement analysis tool. In this paper, we will present a requirement modelling framework with the analysis of modern requirements modelling techniques. Also, we will discuss various domains of requirement engineering with the help of modelling elements such as semantic map of business concepts, lifecycles of business objects, business processes, business rules, system context diagram, use cases and their scenarios, constraints, and user interface prototypes. The proposed framework will be illustrated with the case study of inventory management system.

  8. Knowledge Encapsulation Framework for Collaborative Social Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Cowell, Andrew J.; Gregory, Michelle L.; Marshall, Eric J.; McGrath, Liam R.

    2009-03-24

    This paper describes the Knowledge Encapsulation Framework (KEF), a suite of tools to enable knowledge inputs (relevant, domain-specific facts) to modeling and simulation projects, as well as other domains that require effective collaborative workspaces for knowledge-based task. This framework can be used to capture evidence (e.g., trusted material such as journal articles and government reports), discover new evidence (covering both trusted and social media), enable discussions surrounding domain-specific topics and provide automatically generated semantic annotations for improved corpus investigation. The current KEF implementation is presented within a wiki environment, providing a simple but powerful collaborative space for team members to review, annotate, discuss and align evidence with their modeling frameworks. The novelty in this approach lies in the combination of automatically tagged and user-vetted resources, which increases user trust in the environment, leading to ease of adoption for the collaborative environment.

  9. Impact of cyclosporine reduction with MMF: a randomized trial in chronic allograft dysfunction. The 'reference' study.

    Science.gov (United States)

    Frimat, L; Cassuto-Viguier, E; Charpentier, B; Noël, C; Provôt, F; Rostaing, L; Glotz, D; Sraer, J D; Bourbigot, B; Moulin, B; Lang, P; Ducloux, D; Pouteil-Noble, C; Girardot-Seguin, S; Kessler, M

    2006-11-01

    Long-term use of calcineurine inhibitors (CNIs) may contribute to the development of chronic allograft dysfunction (CAD). We investigate the impact of the introduction of MMF combined with cyclosporine (CsA) 50% dose reduction. An open, randomized, controlled, multicenter, prospective study was conducted in 103 patients, receiving a CsA-based therapy with a serum creatinine between 1.7-3.4 mg/dL, more than 1 year after transplantation. They were randomized to receive MMF with half dose of CsA (MMF group) or to continue their maintenance CsA dose (control group). A total of 96 weeks after randomization, the evolution of renal function assessed by regression line analysis of 1/SeCr improved in the MMF group (positive slope) vs. the control group (negative slope), 4.2 x 10(-4) vs. -3.0 x 10(-4), respectively (p MMF group. No episode of biopsy-proven acute rejection occurred. One patient in each group lost his graft because of biopsy-proven chronic allograft nephropathy. There was a significant decrease of triglycerides level in the MMF group. Anemia and diarrhea were statistically more frequent in the MMF group. In CAD, the reduction of CsA in the presence of MMF results in significant improvement in renal function during a 2-year follow-up.

  10. Reversible chronic pulmonary fibrosis associated with MMF in a pediatric patient: a case report.

    Science.gov (United States)

    Reynolds, B C; Paton, J Y; Howatson, A G; Ramage, I J

    2008-03-01

    We describe a case of chronic mineralizing pulmonary elastosis in a seven-yr-old boy following DD renal transplantation for Wilms tumour. Fourteen months post-transplantation he developed respiratory symptoms with lung biopsy demonstrating chronic mineralizing pulmonary elastosis thought to be secondary to immunosuppression with MMF. Symptomatic resolution occurred following MMF cessation.

  11. High-Resolution Global Modeling of the Effects of Subgrid-Scale Clouds and Turbulence on Precipitating Cloud Systems

    Energy Technology Data Exchange (ETDEWEB)

    Bogenschutz, Peter [National Center for Atmospheric Research, Boulder, CO (United States); Moeng, Chin-Hoh [National Center for Atmospheric Research, Boulder, CO (United States)

    2015-10-13

    The PI’s at the National Center for Atmospheric Research (NCAR), Chin-Hoh Moeng and Peter Bogenschutz, have primarily focused their time on the implementation of the Simplified-Higher Order Turbulence Closure (SHOC; Bogenschutz and Krueger 2013) to the Multi-scale Modeling Framework (MMF) global model and testing of SHOC on deep convective cloud regimes.

  12. Influence of SDZ RAD vs. MMF on gastric emptying in renal transplant recipients.

    Science.gov (United States)

    Maes, Bart D; Evenepoel, Pieter; Kuypers, Dirk; Geypens, Benny; Ghoos, Yvo; Vanrenterghem, Yves

    2003-06-01

    SDZ RAD and mycophenolate mofetil (MMF) are increasingly used in the prevention of renal allograft rejection. SDZ RAD, having a macrolide structure, and MMF, known with gastrointestinal side-effects, may have gastric motility modifying properties. Gastric emptying was examined 1 yr after renal transplantation in eight patients taking corticosteroids (CS), cyclosporin A (CsA) and SDZ RAD and six patients treated with CS, CsA and MMF. Comparing the two groups, no significant differences in gastric emptying of solids and liquids were noted. Compared with normal volunteers, solid gastric emptying was faster in the SDZ RAD group and similar in the MMF group. It is concluded that in stable renal transplant recipients treated with MMF, gastric emptying was normal. Because of the impact on drug absorption and gastrointestinal symptoms, further studies are indicated to corroborate the potential prokinetic properties of SDZ RAD.

  13. A framework of benchmarking land models

    Science.gov (United States)

    Luo, Y. Q.; Randerson, J.; Abramowitz, G.; Bacour, C.; Blyth, E.; Carvalhais, N.; Ciais, P.; Dalmonech, D.; Fisher, J.; Fisher, R.; Friedlingstein, P.; Hibbard, K.; Hoffman, F.; Huntzinger, D.; Jones, C. D.; Koven, C.; Lawrence, D.; Li, D. J.; Mahecha, M.; Niu, S. L.; Norby, R.; Piao, S. L.; Qi, X.; Peylin, P.; Prentice, I. C.; Riley, W.; Reichstein, M.; Schwalm, C.; Wang, Y. P.; Xia, J. Y.; Zaehle, S.; Zhou, X. H.

    2012-02-01

    Land models, which have been developed by the modeling community in the past two decades to predict future states of ecosystems and climate, have to be critically evaluated for their performance skills of simulating ecosystem responses and feedback to climate change. Benchmarking is an emerging procedure to measure and evaluate performance of models against a set of defined standards. This paper proposes a benchmarking framework for evaluation of land models. The framework includes (1) targeted aspects of model performance to be evaluated; (2) a set of benchmarks as defined references to test model performance; (3) metrics to measure and compare performance skills among models so as to identify model strengths and deficiencies; and (4) model improvement. Component 4 may or may not be involved in a benchmark analysis but is an ultimate goal of general modeling research. Land models are required to simulate exchange of water, energy, carbon and sometimes other trace gases between the atmosphere and the land-surface, and should be evaluated for their simulations of biophysical processes, biogeochemical cycles, and vegetation dynamics across timescales in response to both weather and climate change. Benchmarks that are used to evaluate models generally consist of direct observations, data-model products, and data-derived patterns and relationships. Metrics of measuring mismatches between models and benchmarks may include (1) a priori thresholds of acceptable model performance and (2) a scoring system to combine data-model mismatches for various processes at different temporal and spatial scales. The benchmark analyses should identify clues of weak model performance for future improvement. Iterations between model evaluation and improvement via benchmarking shall demonstrate progress of land modeling and help establish confidence in land models for their predictions of future states of ecosystems and climate.

  14. A framework of benchmarking land models

    Directory of Open Access Journals (Sweden)

    Y. Q. Luo

    2012-02-01

    Full Text Available Land models, which have been developed by the modeling community in the past two decades to predict future states of ecosystems and climate, have to be critically evaluated for their performance skills of simulating ecosystem responses and feedback to climate change. Benchmarking is an emerging procedure to measure and evaluate performance of models against a set of defined standards. This paper proposes a benchmarking framework for evaluation of land models. The framework includes (1 targeted aspects of model performance to be evaluated; (2 a set of benchmarks as defined references to test model performance; (3 metrics to measure and compare performance skills among models so as to identify model strengths and deficiencies; and (4 model improvement. Component 4 may or may not be involved in a benchmark analysis but is an ultimate goal of general modeling research. Land models are required to simulate exchange of water, energy, carbon and sometimes other trace gases between the atmosphere and the land-surface, and should be evaluated for their simulations of biophysical processes, biogeochemical cycles, and vegetation dynamics across timescales in response to both weather and climate change. Benchmarks that are used to evaluate models generally consist of direct observations, data-model products, and data-derived patterns and relationships. Metrics of measuring mismatches between models and benchmarks may include (1 a priori thresholds of acceptable model performance and (2 a scoring system to combine data-model mismatches for various processes at different temporal and spatial scales. The benchmark analyses should identify clues of weak model performance for future improvement. Iterations between model evaluation and improvement via benchmarking shall demonstrate progress of land modeling and help establish confidence in land models for their predictions of future states of ecosystems and climate.

  15. Cytoview: Development of a cell modelling framework

    Indian Academy of Sciences (India)

    Prashant Khodade; Samta Malhotra; Nirmal Kumar; M Sriram Iyengar; N Balakrishnan; Nagasuma Chandra

    2007-08-01

    The biological cell, a natural self-contained unit of prime biological importance, is an enormously complex machine that can be understood at many levels. A higher-level perspective of the entire cell requires integration of various features into coherent, biologically meaningful descriptions. There are some efforts to model cells based on their genome, proteome or metabolome descriptions. However, there are no established methods as yet to describe cell morphologies, capture similarities and differences between different cells or between healthy and disease states. Here we report a framework to model various aspects of a cell and integrate knowledge encoded at different levels of abstraction, with cell morphologies at one end to atomic structures at the other. The different issues that have been addressed are ontologies, feature description and model building. The framework describes dotted representations and tree data structures to integrate diverse pieces of data and parametric models enabling size, shape and location descriptions. The framework serves as a first step in integrating different levels of data available for a biological cell and has the potential to lead to development of computational models in our pursuit to model cell structure and function, from which several applications can flow out.

  16. An evaluation framework for participatory modelling

    Science.gov (United States)

    Krueger, T.; Inman, A.; Chilvers, J.

    2012-04-01

    Strong arguments for participatory modelling in hydrology can be made on substantive, instrumental and normative grounds. These arguments have led to increasingly diverse groups of stakeholders (here anyone affecting or affected by an issue) getting involved in hydrological research and the management of water resources. In fact, participation has become a requirement of many research grants, programs, plans and policies. However, evidence of beneficial outcomes of participation as suggested by the arguments is difficult to generate and therefore rare. This is because outcomes are diverse, distributed, often tacit, and take time to emerge. In this paper we develop an evaluation framework for participatory modelling focussed on learning outcomes. Learning encompasses many of the potential benefits of participation, such as better models through diversity of knowledge and scrutiny, stakeholder empowerment, greater trust in models and ownership of subsequent decisions, individual moral development, reflexivity, relationships, social capital, institutional change, resilience and sustainability. Based on the theories of experiential, transformative and social learning, complemented by practitioner experience our framework examines if, when and how learning has occurred. Special emphasis is placed on the role of models as learning catalysts. We map the distribution of learning between stakeholders, scientists (as a subgroup of stakeholders) and models. And we analyse what type of learning has occurred: instrumental learning (broadly cognitive enhancement) and/or communicative learning (change in interpreting meanings, intentions and values associated with actions and activities; group dynamics). We demonstrate how our framework can be translated into a questionnaire-based survey conducted with stakeholders and scientists at key stages of the participatory process, and show preliminary insights from applying the framework within a rural pollution management situation in

  17. Talking Cure Models: A Framework of Analysis

    Science.gov (United States)

    Marx, Christopher; Benecke, Cord; Gumz, Antje

    2017-01-01

    Psychotherapy is commonly described as a “talking cure,” a treatment method that operates through linguistic action and interaction. The operative specifics of therapeutic language use, however, are insufficiently understood, mainly due to a multitude of disparate approaches that advance different notions of what “talking” means and what “cure” implies in the respective context. Accordingly, a clarification of the basic theoretical structure of “talking cure models,” i.e., models that describe therapeutic processes with a focus on language use, is a desideratum of language-oriented psychotherapy research. Against this background the present paper suggests a theoretical framework of analysis which distinguishes four basic components of “talking cure models”: (1) a foundational theory (which suggests how linguistic activity can affect and transform human experience), (2) an experiential problem state (which defines the problem or pathology of the patient), (3) a curative linguistic activity (which defines linguistic activities that are supposed to effectuate a curative transformation of the experiential problem state), and (4) a change mechanism (which defines the processes and effects involved in such transformations). The purpose of the framework is to establish a terminological foundation that allows for systematically reconstructing basic properties and operative mechanisms of “talking cure models.” To demonstrate the applicability and utility of the framework, five distinct “talking cure models” which spell out the details of curative “talking” processes in terms of (1) catharsis, (2) symbolization, (3) narrative, (4) metaphor, and (5) neurocognitive inhibition are introduced and discussed in terms of the framework components. In summary, we hope that our framework will prove useful for the objective of clarifying the theoretical underpinnings of language-oriented psychotherapy research and help to establish a more comprehensive

  18. A framework for benchmarking land models

    Science.gov (United States)

    Luo, Y. Q.; Randerson, J. T.; Abramowitz, G.; Bacour, C.; Blyth, E.; Carvalhais, N.; Ciais, P.; Dalmonech, D.; Fisher, J. B.; Fisher, R.; Friedlingstein, P.; Hibbard, K.; Hoffman, F.; Huntzinger, D.; Jones, C. D.; Koven, C.; Lawrence, D.; Li, D. J.; Mahecha, M.; Niu, S. L.; Norby, R.; Piao, S. L.; Qi, X.; Peylin, P.; Prentice, I. C.; Riley, W.; Reichstein, M.; Schwalm, C.; Wang, Y. P.; Xia, J. Y.; Zaehle, S.; Zhou, X. H.

    2012-10-01

    Land models, which have been developed by the modeling community in the past few decades to predict future states of ecosystems and climate, have to be critically evaluated for their performance skills of simulating ecosystem responses and feedback to climate change. Benchmarking is an emerging procedure to measure performance of models against a set of defined standards. This paper proposes a benchmarking framework for evaluation of land model performances and, meanwhile, highlights major challenges at this infant stage of benchmark analysis. The framework includes (1) targeted aspects of model performance to be evaluated, (2) a set of benchmarks as defined references to test model performance, (3) metrics to measure and compare performance skills among models so as to identify model strengths and deficiencies, and (4) model improvement. Land models are required to simulate exchange of water, energy, carbon and sometimes other trace gases between the atmosphere and land surface, and should be evaluated for their simulations of biophysical processes, biogeochemical cycles, and vegetation dynamics in response to climate change across broad temporal and spatial scales. Thus, one major challenge is to select and define a limited number of benchmarks to effectively evaluate land model performance. The second challenge is to develop metrics of measuring mismatches between models and benchmarks. The metrics may include (1) a priori thresholds of acceptable model performance and (2) a scoring system to combine data-model mismatches for various processes at different temporal and spatial scales. The benchmark analyses should identify clues of weak model performance to guide future development, thus enabling improved predictions of future states of ecosystems and climate. The near-future research effort should be on development of a set of widely acceptable benchmarks that can be used to objectively, effectively, and reliably evaluate fundamental properties of land models

  19. A framework for benchmarking land models

    Directory of Open Access Journals (Sweden)

    Y. Q. Luo

    2012-10-01

    Full Text Available Land models, which have been developed by the modeling community in the past few decades to predict future states of ecosystems and climate, have to be critically evaluated for their performance skills of simulating ecosystem responses and feedback to climate change. Benchmarking is an emerging procedure to measure performance of models against a set of defined standards. This paper proposes a benchmarking framework for evaluation of land model performances and, meanwhile, highlights major challenges at this infant stage of benchmark analysis. The framework includes (1 targeted aspects of model performance to be evaluated, (2 a set of benchmarks as defined references to test model performance, (3 metrics to measure and compare performance skills among models so as to identify model strengths and deficiencies, and (4 model improvement. Land models are required to simulate exchange of water, energy, carbon and sometimes other trace gases between the atmosphere and land surface, and should be evaluated for their simulations of biophysical processes, biogeochemical cycles, and vegetation dynamics in response to climate change across broad temporal and spatial scales. Thus, one major challenge is to select and define a limited number of benchmarks to effectively evaluate land model performance. The second challenge is to develop metrics of measuring mismatches between models and benchmarks. The metrics may include (1 a priori thresholds of acceptable model performance and (2 a scoring system to combine data–model mismatches for various processes at different temporal and spatial scales. The benchmark analyses should identify clues of weak model performance to guide future development, thus enabling improved predictions of future states of ecosystems and climate. The near-future research effort should be on development of a set of widely acceptable benchmarks that can be used to objectively, effectively, and reliably evaluate fundamental properties

  20. Computer-aided modeling framework – a generic modeling template

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    This work focuses on the development of a computer-aided modeling framework. The framework is a knowledge-based system that is built on a generic modeling language and structured on workflows for different modeling tasks. The overall objective is to support model developers and users to generate...... and test models systematically, efficiently and reliably. In this way, development of products and processes can be made faster, cheaper and more efficient. In this contribution, as part of the framework, a generic modeling template for the systematic derivation of problem specific models is presented....... The application of the modeling template is highlighted with a case study related to the modeling of a catalytic membrane reactor coupling dehydrogenation of ethylbenzene with hydrogenation of nitrobenzene...

  1. Mycophenolate mofetil (MMF) for the treatment of steroid-resistant idiopathic thrombocytopenic purpura.

    Science.gov (United States)

    Hou, Ming; Peng, Jun; Shi, Yan; Zhang, Chunqing; Qin, Ping; Zhao, Chuanli; Ji, Xuebin; Wang, Xueyong; Zhang, Maohong

    2003-06-01

    The treatment of chronic idiopathic thrombocytopenic purpura (ITP) is difficult in those unresponsive to corticosteroids and/or splenectomy. We attempted to induce durable response in 21 patients with refractory ITP by applying mycophenolate mofetil (MMF) (1.5-2.0 g/d), a novel immunosuppressive agent. Overall response rate was 62% (13 of 21), including 24% (five of 21) in complete response (CR), 29% (six of 21) in partial response (PR), and 10% (two of 21) in minor response (MR). The response rates for non-splenectomized and splenectomized ITP patients were 64% (nine of 14) and 57% (four of seven), respectively (P > 0.05). 39% (five of 13) responders relapsed as a result of dose reduction or withdraw of MMF, and 61% (eight of 13) responders maintained their effectiveness for a median of 24 wk. Sustained response was observed in three patients in whom MMF was withdrawn. MMF was well tolerated with only slight nausea and diarrhea recorded in 3 of 21 cases. No premature withdrawal was found in this study. CD3+ peripheral blood mononuclear cells (PBMC) and CD19+ PBMC were significantly reduced 12 wk after MMF administration in the responders. Platelet-associated antibodies against glycoproteins GPIIb/IIIa were detected in 13 of 21 (62%) patients before MMF treatment, and antibody levels were significantly decreased in responders 12 wk after MMF administration. This suggested that MMF might correct the immunologic abnormalities underlying the destruction of circulating platelets in ITP. We conclude that MMF could be used as a second-line agent for the treatment of steroid-resistant ITP before or after splenectomy and thereby is worth of further evaluation in randomized studies.

  2. In-Building Wireless Distribution in legacy Multimode Fiber with an improved RoMMF system

    DEFF Research Database (Denmark)

    Visani, Davide; Petersen, Martin Nordal; Sorci, Francesca

    2012-01-01

    A radio over multimode fiber (RoMMF) system for in-building wireless distribution employing a directly modulated Fabry-Perot (FP) transmitter and the central launch technique is presented. The worst-case spurious free dynamic range (SFDR) exceeds 105 dB×Hz2/3 up to 525 m of OM2 multimode fiber (MMF......). Experimental and theoretical results are reported showing that this scheme outperforms a RoMMF system employing a distributed feed-back (DFB) laser diode (LD) and/or a mode scrambler to achieve overfilled launch (OFL). Long Term Evolution (LTE) signal transmission is achieved with high quality in terms...

  3. An entropic framework for modeling economies

    Science.gov (United States)

    Caticha, Ariel; Golan, Amos

    2014-08-01

    We develop an information-theoretic framework for economic modeling. This framework is based on principles of entropic inference that are designed for reasoning on the basis of incomplete information. We take the point of view of an external observer who has access to limited information about broad macroscopic economic features. We view this framework as complementary to more traditional methods. The economy is modeled as a collection of agents about whom we make no assumptions of rationality (in the sense of maximizing utility or profit). States of statistical equilibrium are introduced as those macrostates that maximize entropy subject to the relevant information codified into constraints. The basic assumption is that this information refers to supply and demand and is expressed in the form of the expected values of certain quantities (such as inputs, resources, goods, production functions, utility functions and budgets). The notion of economic entropy is introduced. It provides a measure of the uniformity of the distribution of goods and resources. It captures both the welfare state of the economy as well as the characteristics of the market (say, monopolistic, concentrated or competitive). Prices, which turn out to be the Lagrange multipliers, are endogenously generated by the economy. Further studies include the equilibrium between two economies and the conditions for stability. As an example, the case of the nonlinear economy that arises from linear production and utility functions is treated in some detail.

  4. MDM: A Mode Diagram Modeling Framework

    Directory of Open Access Journals (Sweden)

    Zheng Wang

    2012-12-01

    Full Text Available Periodic control systems used in spacecrafts and automotives are usually period-driven and can be decomposed into different modes with each mode representing a system state observed from outside. Such systems may also involve intensive computing in their modes. Despite the fact that such control systems are widely used in the above-mentioned safety-critical embedded domains, there is lack of domain-specific formal modelling languages for such systems in the relevant industry. To address this problem, we propose a formal visual modeling framework called mode diagram as a concise and precise way to specify and analyze such systems. To capture the temporal properties of periodic control systems, we provide, along with mode diagram, a property specification language based on interval logic for the description of concrete temporal requirements the engineers are concerned with. The statistical model checking technique can then be used to verify the mode diagram models against desired properties. To demonstrate the viability of our approach, we have applied our modelling framework to some real life case studies from industry and helped detect two design defects for some spacecraft control systems.

  5. Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles?

    Science.gov (United States)

    van Leuven, Sander I; Kastelein, John J P; Allison, Anthony C; Hayden, Michael R; Stroes, Erik S G

    2006-02-01

    Atherosclerosis is characterized by a persistent, low-grade inflammatory state in which immune cell activation is inseparably linked to plaque formation and destabilization. The T-lymphocyte in particular has emerged as a pivotal player throughout the course of atherogenesis. As a consequence, the concept that immune modulation is a suitable target for cardiovascular prevention is currently an important focus of research. Mycophenolate mofetil (MMF) has emerged as a non-competitive inhibitor of inosine monophosphate dehydrogenase (IMPDH) that exerts cytostatic effects, particularly on proliferating T-lymphocytes. In addition, MMF has other immune-modulating effects, such as downregulation of the expression of adhesion molecules and attenuation of monocyte and macrophage responses. Given the added benefit that MMF is well tolerated, this immunosuppressive agent constitutes an attractive candidate for the modulation of inflammatory activation in atherogenesis. The present review provides an overview of the potential anti-atherogenic properties of MMF.

  6. Improving the capacity of short-reach VCSEL-based MMF optical links

    DEFF Research Database (Denmark)

    Tatarczak, Anna; Lu, Xiaofeng; Tafur Monroy, Idelfonso

    2016-01-01

    We summarize strategies for increasing a capacity of short-reach links that base on an 850 nm VCSEL and an MMF. Presented methods include advanced modulation formats, equalization, WDM, quasi-single mode sources and a selective mode launch.......We summarize strategies for increasing a capacity of short-reach links that base on an 850 nm VCSEL and an MMF. Presented methods include advanced modulation formats, equalization, WDM, quasi-single mode sources and a selective mode launch....

  7. A Framework of Memory Consistency Models

    Institute of Scientific and Technical Information of China (English)

    胡伟武; 施巍松; 等

    1998-01-01

    Previous descriptions of memory consistency models in shared-memory multiprocessor systems are mainly expressed as constraints on the memory access event ordering and hence are hardware-centric.This paper presents a framework of memory consistency models which describes the memory consistency model on the behavior level.Based on the understanding that the behavior of an execution is determined by the execution order of conflicting accesses,a memory consistency model is defined as an interprocessor synchronization mechanism which orders the execution of operations from different processors.Synchronization order of an execution under certain consistency model is also defined.The synchronization order,together with the program order determines the behavior of an execution.This paper also presents criteria for correct program and correct implementation of consistency models.Regarding an implementation of a consistency model as certain memory event ordering constraints,this paper provides a method to prove the correctness of consistency model implementations,and the correctness of the lock-based cache coherence protocol is proved with this method.

  8. Assessing the diurnal cycle of precipitation in a multi-scale climate model

    Directory of Open Access Journals (Sweden)

    Michael S Pritchard

    2009-10-01

    Full Text Available A promising result that has emerged from the new Multi-scale Modeling Framework (MMF approach to atmospheric modeling is a global improvement in the daily timing of peak precipitation over the continents, which is suggestive of improved moist dynamics at diurnal timescales overall. We scrutinize the simulated seasonal composite diurnal cycle of precipitation in an MMF developed by the Center for Multiscale Modeling of Atmospheric Processes (CMMAP using a comprehensive suite of diurnal cycle diagnostics including traditional harmonic analysis, and non-traditional diagnostics such as the broadness of the peak precipitation in the mean summer day, reduced dimension transect analysis, and animations of the full spatial and temporal variability of the composite mean summer day. Precipitation in the MMF is evaluated against multi-satellite merged satellite data and a control simulation with a climate model that employs conventional cloud and boundary layer parameterizations. Our analysis highlights several improved features of the diurnal cycle of precipitation in the multi-scale climate model: It is less sinusoidal over the most energetic diurnal rainfall regimes, more horizontally inhomogeneous within continents and oceans, and more faithful to observed structural transitions in the composite diurnal cycle chronology straddling coastlines than the conventional climate model. A regional focus on North America links a seasonal summer dry bias over the continental United States in the CMMAP MMF at T42 resolution to its inability to capture diurnally propagating precipitation signals associated with organized convection in the lee of the Rockies. The chronology of precipitation events elsewhere in the vicinity of North America is improved in the MMF, especially over sea breeze circulation regions along the eastern seaboard and the Gulf of Mexico, as well as over the entirety of the Gulf Stream. Comparison of the convective heating and moistening

  9. A Procurement Performance Model for Construction Frameworks

    Directory of Open Access Journals (Sweden)

    Terence Y M Lam

    2015-07-01

    Full Text Available Collaborative construction frameworks have been developed in the United Kingdom (UK to create longer term relationships between clients and suppliers in order to improve project outcomes. Research undertaken into highways maintenance set within a major county council has confirmed that such collaborative procurement methods can improve time, cost and quality of construction projects. Building upon this and examining the same single case, this research aims to develop a performance model through identification of performance drivers in the whole project delivery process including pre and post contract phases. A priori performance model based on operational and sociological constructs was proposed and then checked by a pilot study. Factor analysis and central tendency statistics from the questionnaires as well as content analysis from the interview transcripts were conducted. It was confirmed that long term relationships, financial and non-financial incentives and stronger communication are the sociological behaviour factors driving performance. The interviews also established that key performance indicators (KPIs can be used as an operational measure to improve performance. With the posteriori performance model, client project managers can effectively collaboratively manage contractor performance through procurement measures including use of longer term and KPIs for the contract so that the expected project outcomes can be achieved. The findings also make significant contribution to construction framework procurement theory by identifying the interrelated sociological and operational performance drivers. This study is set predominantly in the field of highways civil engineering. It is suggested that building based projects or other projects that share characteristics are grouped together and used for further research of the phenomena discovered.

  10. Conceptual Frameworks in the Doctoral Research Process: A Pedagogical Model

    Science.gov (United States)

    Berman, Jeanette; Smyth, Robyn

    2015-01-01

    This paper contributes to consideration of the role of conceptual frameworks in the doctoral research process. Through reflection on the two authors' own conceptual frameworks for their doctoral studies, a pedagogical model has been developed. The model posits the development of a conceptual framework as a core element of the doctoral…

  11. Analysis of second order harmonic distortion due to transmitter non-linearity and chromatic and modal dispersion of optical OFDM SSB modulated signals in SMF-MMF fiber links

    Science.gov (United States)

    Patel, Dhananjay; Singh, Vinay Kumar; Dalal, U. D.

    2017-01-01

    Single mode fibers (SMF) are typically used in Wide Area Networks (WAN), Metropolitan Area Networks (MAN) and also find applications in Radio over Fiber (RoF) architectures supporting data transmission in Fiber to the Home (FTTH), Remote Antenna Units (RAUs), in-building networks etc. Multi-mode fibers (MMFs) with low cost, ease of installation and low maintenance are predominantly (85-90%) deployed in-building networks providing data access in local area networks (LANs). The transmission of millimeter wave signals through the SMF in WAN and MAN, along with the reuse of MMF in-building networks will not levy fiber reinstallation cost. The transmission of the millimeter waves experiences signal impairments due to the transmitter non-linearity and modal dispersion of the MMF. The MMF exhibiting large modal dispersion limits the bandwidth-length product of the fiber. The second and higher-order harmonics present in the optical signal fall within the system bandwidth. This causes degradation in the received signal and an unwanted radiation of power at the RAU. The power of these harmonics is proportional to the non-linearity of the transmitter and the modal dispersion of the MMF and should be maintained below the standard values as per the international norms. In this paper, a mathematical model is developed for Second-order Harmonic Distortion (HD2) generated due to non-linearity of the transmitter and chromatic-modal dispersion of the SMF-MMF optic link. This is also verified using a software simulation. The model consists of a Mach Zehnder Modulator (MZM) that generates two m-QAM OFDM Single Sideband (SSB) signals based on phase shift of the hybrid coupler (90° and 120°). Our results show that the SSB signal with 120° hybrid coupler has suppresses the higher-order harmonics and makes the system more robust against the HD2 in the SMF-MMF optic link.

  12. The Conceptual Integration Modeling Framework: Abstracting from the Multidimensional Model

    CERN Document Server

    Rizzolo, Flavio; Pottinger, Rachel; Wong, Kwok

    2010-01-01

    Data warehouses are overwhelmingly built through a bottom-up process, which starts with the identification of sources, continues with the extraction and transformation of data from these sources, and then loads the data into a set of data marts according to desired multidimensional relational schemas. End user business intelligence tools are added on top of the materialized multidimensional schemas to drive decision making in an organization. Unfortunately, this bottom-up approach is costly both in terms of the skilled users needed and the sheer size of the warehouses. This paper proposes a top-down framework in which data warehousing is driven by a conceptual model. The framework offers both design time and run time environments. At design time, a business user first uses the conceptual modeling language as a multidimensional object model to specify what business information is needed; then she maps the conceptual model to a pre-existing logical multidimensional representation. At run time, a system will tra...

  13. Model based risk assessment - the CORAS framework

    Energy Technology Data Exchange (ETDEWEB)

    Gran, Bjoern Axel; Fredriksen, Rune; Thunem, Atoosa P-J.

    2004-04-15

    Traditional risk analysis and assessment is based on failure-oriented models of the system. In contrast to this, model-based risk assessment (MBRA) utilizes success-oriented models describing all intended system aspects, including functional, operational and organizational aspects of the target. The target models are then used as input sources for complementary risk analysis and assessment techniques, as well as a basis for the documentation of the assessment results. The EU-funded CORAS project developed a tool-supported methodology for the application of MBRA in security-critical systems. The methodology has been tested with successful outcome through a series of seven trial within the telemedicine and ecommerce areas. The CORAS project in general and the CORAS application of MBRA in particular have contributed positively to the visibility of model-based risk assessment and thus to the disclosure of several potentials for further exploitation of various aspects within this important research field. In that connection, the CORAS methodology's possibilities for further improvement towards utilization in more complex architectures and also in other application domains such as the nuclear field can be addressed. The latter calls for adapting the framework to address nuclear standards such as IEC 60880 and IEC 61513. For this development we recommend applying a trial driven approach within the nuclear field. The tool supported approach for combining risk analysis and system development also fits well with the HRP proposal for developing an Integrated Design Environment (IDE) providing efficient methods and tools to support control room systems design. (Author)

  14. A Smallholder Socio-hydrological Modelling Framework

    Science.gov (United States)

    Pande, S.; Savenije, H.; Rathore, P.

    2014-12-01

    Small holders are farmers who own less than 2 ha of farmland. They often have low productivity and thus remain at subsistence level. A fact that nearly 80% of Indian farmers are smallholders, who merely own a third of total farmlands and belong to the poorest quartile, but produce nearly 40% of countries foodgrains underlines the importance of understanding the socio-hydrology of a small holder. We present a framework to understand the socio-hydrological system dynamics of a small holder. It couples the dynamics of 6 main variables that are most relevant at the scale of a small holder: local storage (soil moisture and other water storage), capital, knowledge, livestock production, soil fertility and grass biomass production. The model incorporates rule-based adaptation mechanisms (for example: adjusting expenditures on food and fertilizers, selling livestocks etc.) of small holders when they face adverse socio-hydrological conditions, such as low annual rainfall, higher intra-annual variability in rainfall or variability in agricultural prices. It allows us to study sustainability of small holder farming systems under various settings. We apply the framework to understand the socio-hydrology of small holders in Aurangabad, Maharashtra, India. This district has witnessed suicides of many sugarcane farmers who could not extricate themselves out of the debt trap. These farmers lack irrigation and are susceptible to fluctuating sugar prices and intra-annual hydroclimatic variability. This presentation discusses two aspects in particular: whether government interventions to absolve the debt of farmers is enough and what is the value of investing in local storages that can buffer intra-annual variability in rainfall and strengthening the safety-nets either by creating opportunities for alternative sources of income or by crop diversification.

  15. Systematic identification of crystallization kinetics within a generic modelling framework

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Meisler, Kresten Troelstrup; Gernaey, Krist

    2012-01-01

    A systematic development of constitutive models within a generic modelling framework has been developed for use in design, analysis and simulation of crystallization operations. The framework contains a tool for model identification connected with a generic crystallizer modelling tool-box, a tool...

  16. Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital.

    Science.gov (United States)

    Fahimi, Fanak; Baniasadi, Shadi; Mortazavi, Seyed Alireza; Dehghan, Hanie; Zarghi, Afshin

    2012-01-01

    To evaluate the physical and chemical stability of a suspension of mycophenolate mofetil (MMF) prepared in the hospital from commercially available MMF capsules and tablets. Extemporaneous pharmacy was used as a feasible method in this experimental study to prepare suspension form of MMF. Suspension formulations were prepared from both tablets and capsules forms of MMF. Thereafter the stability parameters such as pH, microbial control, thermal and physical stability and particle sizes were evaluated. The amount of MMF, in the suspension was measured at various time points by HPLC. The HPLC method showed that concentration of suspensions prepared from tablets and capsules were 49 mg/mL and 50 mg/mL at time 0, respectively. The effective amount of suspensions prepared from capsules was 101% at time 0, 100% after 7 days, 98% after 14 days, and less than 70% after 28 days. According to the obtained results in this study, capsule-based suspension was stable for as long as 14 days at 5°C. This formulation appears to be clinically acceptable and provides a convenient dosage form for pediatric patients and for adults during the early postoperative period.

  17. Making sense of implementation theories, models and frameworks

    National Research Council Canada - National Science Library

    Nilsen, Per

    2015-01-01

    .... The aim of this article is to propose a taxonomy that distinguishes between different categories of theories, models and frameworks in implementation science, to facilitate appropriate selection...

  18. Modeling Framework for Mining Lifecycle Management

    Directory of Open Access Journals (Sweden)

    Na Lu

    2014-03-01

    Full Text Available In the development process of the information of the mining engineering, it is difficult to directly exchange and share information in the different phases and different application system, which causes the information isolation and information gap due to lack of unified data exchange standards and information integration mechanism. The purpose of this research is to build a modeling framework for mining lifecycle information management. The conception of mining lifecycle management (MLM is proposed based on product lifecycle management (PLM and Hall three dimension structures. The frame system of mining lifecycle management has been established by the application route of the information integration technologies and information standards. The four-layer structure of the realization of MLM system is put forward, which draws up the development method of MLM system. -The application indicates that the proposed theories and technologies have solved the problem of information isolation in different phases and application in mining engineering, and have laid a foundation for information exchange, sharing and integration in mining lifecycle.

  19. An Exploratory Investigation on the Invasiveness of Environmental Modeling Frameworks

    Science.gov (United States)

    This paper provides initial results of an exploratory investigation on the invasiveness of environmental modeling frameworks. Invasiveness is defined as the coupling between application (i.e., model) and framework code used to implement the model. By comparing the implementation of an environmenta...

  20. A Software Service Framework Model Based on Agent

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper presents an agent-based software service framework model called ASF, and definesthe basic concepts and structure of ASF model. It also describes the management and process mechanismsin ASF model.

  1. Business model framework applications in health care: A systematic review.

    Science.gov (United States)

    Fredriksson, Jens Jacob; Mazzocato, Pamela; Muhammed, Rafiq; Savage, Carl

    2017-01-01

    It has proven to be a challenge for health care organizations to achieve the Triple Aim. In the business literature, business model frameworks have been used to understand how organizations are aligned to achieve their goals. We conducted a systematic literature review with an explanatory synthesis approach to understand how business model frameworks have been applied in health care. We found a large increase in applications of business model frameworks during the last decade. E-health was the most common context of application. We identified six applications of business model frameworks: business model description, financial assessment, classification based on pre-defined typologies, business model analysis, development, and evaluation. Our synthesis suggests that the choice of business model framework and constituent elements should be informed by the intent and context of application. We see a need for harmonization in the choice of elements in order to increase generalizability, simplify application, and help organizations realize the Triple Aim.

  2. Towards 100 Gbps over 100m MMF using a 850nm VCSEL

    DEFF Research Database (Denmark)

    Iglesias Olmedo, Miguel; Tatarczak, Anna; Zuo, Tianjian

    2014-01-01

    Employing MultiCAP signaling, successful 70.4 Gbps transmission over 100m of OM3 MMF using off-the-shelf 850 nm VCSEL with 10.1 GHz 3-dB bandwidth is experimentally demonstrated indicating the feasibility of achieving 100 Gbps with a single 25 GHz VCSEL. © 2014 OSA.......Employing MultiCAP signaling, successful 70.4 Gbps transmission over 100m of OM3 MMF using off-the-shelf 850 nm VCSEL with 10.1 GHz 3-dB bandwidth is experimentally demonstrated indicating the feasibility of achieving 100 Gbps with a single 25 GHz VCSEL. © 2014 OSA....

  3. SMF/MMF Based In-building Gigabit Wireless Access Systems Using Simplified 60-GHz Transceivers

    DEFF Research Database (Denmark)

    Pham, Tien Thang; Lebedev, Alexander; Beltrán, M.

    2011-01-01

    Hybrid fiber-wireless transmission of 2-Gbps signals in 60-GHz band over a composite channel (10-km SMF/1-km MMF/6.5-m wireless) is experimentally demonstrated for gigabit inbuilding wireless access using simple direct modulation, optical upconversion and envelope detection.......Hybrid fiber-wireless transmission of 2-Gbps signals in 60-GHz band over a composite channel (10-km SMF/1-km MMF/6.5-m wireless) is experimentally demonstrated for gigabit inbuilding wireless access using simple direct modulation, optical upconversion and envelope detection....

  4. Modeling of a Single Multimode Fiber Imaging System

    CERN Document Server

    Liu, Chen; Liu, Deming; Su, Lei

    2016-01-01

    We present a detailed theoretical analysis on image transmission via a single multimode fiber (MMF). A single MMF imaging model is developed to study the light wave propagation from the light source to the camera, by using free-space Fourier optics theory and mode-coupling theory. A mathematical expression is obtained for the complete single MMF imaging system, which is further validated by image-transmission simulations. Our model is believed to be the first theoretical model to describe the complete MMF imaging system based on the transmission of individual modes. Therefore, this model is robust and capable of analyzing MMF image transmission under specific mode-coupling conditions. We use our model to study bending-induced image blur in single-MMF image transmission, and the result has found a good agreement with that of existing experimental studies. These should provide important insights into future MMF imaging system developments.

  5. LAMMPS Framework for Dynamic Bonding and an Application Modeling DNA

    DEFF Research Database (Denmark)

    Svaneborg, Carsten

    2012-01-01

    and bond types. When breaking bonds, all angular and dihedral interactions involving broken bonds are removed. The framework allows chemical reactions to be modeled, and use it to simulate a simplistic, coarse-grained DNA model. The resulting DNA dynamics illustrates the power of the present framework....

  6. Introduction of MMF in conjunction with stepwise reduction of calcineurin inhibitor in stable liver transplant patients with renal dysfunction.

    Science.gov (United States)

    Kornberg, Arno; Küpper, Bernadette; Hommann, Merten; Scheele, Johannes

    2005-01-01

    Mycophenolat mofetil (MMF) is a new imunosuppressant without nephrotoxic adverse effects. The aim of this study was to evaluate feasibility and effect of MMF introduction in conjunction with stepwise reduction of calcineurin inhibitors (CNI) in stable liver transplant patients with chronic CNI-induced renal dysfunction (RDF). In the MMF-group (n=27) but not in the controls (n=16), mean serum level of creatinine fell from a baseline of 227.4+/-67.9 micromol/l to 159.2+/-48.2 micromol/l (PMMF. Additionally, systolic and diastolic blood pressure values improved. In 52% of patients, dose reduction (n=11) or withdrawal (n=3) of MMF was necessary due to gastrointestinal or hematologic adverse effects. But also in patients on low dose MMF, there was a significant improvement of renal function without increased immunological risk.

  7. IDEF method-based simulation model design and development framework

    Directory of Open Access Journals (Sweden)

    Ki-Young Jeong

    2009-09-01

    Full Text Available The purpose of this study is to provide an IDEF method-based integrated framework for a business process simulation model to reduce the model development time by increasing the communication and knowledge reusability during a simulation project. In this framework, simulation requirements are collected by a function modeling method (IDEF0 and a process modeling method (IDEF3. Based on these requirements, a common data model is constructed using the IDEF1X method. From this reusable data model, multiple simulation models are automatically generated using a database-driven simulation model development approach. The framework is claimed to help both requirement collection and experimentation phases during a simulation project by improving system knowledge, model reusability, and maintainability through the systematic use of three descriptive IDEF methods and the features of the relational database technologies. A complex semiconductor fabrication case study was used as a testbed to evaluate and illustrate the concepts and the framework. Two different simulation software products were used to develop and control the semiconductor model from the same knowledge base. The case study empirically showed that this framework could help improve the simulation project processes by using IDEF-based descriptive models and the relational database technology. Authors also concluded that this framework could be easily applied to other analytical model generation by separating the logic from the data.

  8. A Simulation and Modeling Framework for Space Situational Awareness

    Energy Technology Data Exchange (ETDEWEB)

    Olivier, S S

    2008-09-15

    This paper describes the development and initial demonstration of a new, integrated modeling and simulation framework, encompassing the space situational awareness enterprise, for quantitatively assessing the benefit of specific sensor systems, technologies and data analysis techniques. The framework is based on a flexible, scalable architecture to enable efficient, physics-based simulation of the current SSA enterprise, and to accommodate future advancements in SSA systems. In particular, the code is designed to take advantage of massively parallel computer systems available, for example, at Lawrence Livermore National Laboratory. The details of the modeling and simulation framework are described, including hydrodynamic models of satellite intercept and debris generation, orbital propagation algorithms, radar cross section calculations, optical brightness calculations, generic radar system models, generic optical system models, specific Space Surveillance Network models, object detection algorithms, orbit determination algorithms, and visualization tools. The use of this integrated simulation and modeling framework on a specific scenario involving space debris is demonstrated.

  9. Zheng Zhiyi, Vows a Breakthrough in High-tech Fibers in MMF Industry

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ As an annual calendar event, China's International Manmade Fiber Conference sets out, as always as it started over 20 years ago, to provide an international platform at its 13th International Conference for technical exchange and cooperation in an effort to direct Chinese MMF's future roadmap.

  10. [A case of combination therapy with MMF and steroids for idiopathic membranoproliferative glomerulonephritis].

    Science.gov (United States)

    Mori, Yutaro; Ihara, Katsuhito; Yamaguchi, Wakaba; Fujii, Tetsuro; Toda, Takayuki; Nagata, Michio; Matsui, Noriaki

    2013-01-01

    A 26-year-old man diagnosed with nephrotic syndrome was administered steroid monotherapy. Urinary protein excretion was 2-3 g/day despite the therapy. Percutaneous renal biopsy revealed Type I idiopathic membranoproliferative glomerulonephritis (IMPGN). Although intravenous steroid therapy at the dose of 1,000 mg/day for 3 days was administered, proteinuria persisted at the level of 1 g/day. Renal dysfunction (cystatin C, 1.33 mg/L) was evident. Strong inflammation was suggested by occult blood (3+) and urinary (red blood cells: 30-50/high power field) sediment. We considered steroid monotherapy to be ineffective, and initiated combina-tion therapy with mycophenolate mofetil (MMF) and steroids. Consequently, urinary protein excretion moderately decreased to 0.34 g/day without adverse events or worsening of the renal function. The steroid quantity could be reduced without relapse. Subsequently, we were able to reduce the dose of MMF gradually, then terminated the medication. IMPGN is a rare disease with a poor renal prognosis. Recently, MMF therapies for IMPGN have been attempted, but there are few cases in Japan. Our case suggests that combination therapy with MMF and steroids is effective and safe for treating IMPGN.

  11. The 13th China International MMF Conference: How to be more environmental-friendly?

    Institute of Scientific and Technical Information of China (English)

    Wang Ting

    2007-01-01

    @@ On September 13-14th, the 13th China International Man-made Fiber Conference (Ke Qiao 2007) was held in the county of Ke Qiao, Shaoxing County, Zhejiang Province of China,attacting worldwide attention and large participation from the global MMF chain.

  12. Modelling Framework of a Neural Object Recognition

    Directory of Open Access Journals (Sweden)

    Aswathy K S

    2016-02-01

    Full Text Available In many industrial, medical and scientific image processing applications, various feature and pattern recognition techniques are used to match specific features in an image with a known template. Despite the capabilities of these techniques, some applications require simultaneous analysis of multiple, complex, and irregular features within an image as in semiconductor wafer inspection. In wafer inspection discovered defects are often complex and irregular and demand more human-like inspection techniques to recognize irregularities. By incorporating neural network techniques such image processing systems with much number of images can be trained until the system eventually learns to recognize irregularities. The aim of this project is to develop a framework of a machine-learning system that can classify objects of different category. The framework utilizes the toolboxes in the Matlab such as Computer Vision Toolbox, Neural Network Toolbox etc.

  13. An object-oriented modelling framework for the arterial wall.

    Science.gov (United States)

    Balaguera, M I; Briceño, J C; Glazier, J A

    2010-02-01

    An object-oriented modelling framework for the arterial wall is presented. The novelty of the framework is the possibility to generate customizable artery models, taking advantage of imaging technology. In our knowledge, this is the first object-oriented modelling framework for the arterial wall. Existing models do not allow close structural mapping with arterial microstructure as in the object-oriented framework. In the implemented model, passive behaviour of the arterial wall was considered and the tunica adventitia was the objective system. As verification, a model of an arterial segment was generated. In order to simulate its deformation, a matrix structural mechanics simulator was implemented. Two simulations were conducted, one for an axial loading test and other for a pressure-volume test. Each simulation began with a sensitivity analysis in order to determinate the best parameter combination and to compare the results with analogue controls. In both cases, the simulated results closely reproduced qualitatively and quantitatively the analogue control plots.

  14. An Ontology-Based Framework for Modeling User Behavior

    DEFF Research Database (Denmark)

    Razmerita, Liana

    2011-01-01

    This paper focuses on the role of user modeling and semantically enhanced representations for personalization. This paper presents a generic Ontology-based User Modeling framework (OntobUMf), its components, and its associated user modeling processes. This framework models the behavior of the users....... The results of this research may contribute to the development of other frameworks for modeling user behavior, other semantically enhanced user modeling frameworks, or other semantically enhanced information systems....... and classifies its users according to their behavior. The user ontology is the backbone of OntobUMf and has been designed according to the Information Management System Learning Information Package (IMS LIP). The user ontology includes a Behavior concept that extends IMS LIP specification and defines...

  15. A Mathematical Modeling Framework for Analysis of Functional Clothing

    Directory of Open Access Journals (Sweden)

    Xiaolin Man

    2007-11-01

    Full Text Available In the analysis and design of functional clothing systems, it is helpful to quantify the effects of a system on a wearer’s physical performance capabilities. Toward this end, a clothing modeling framework for quantifying the mechanical interactions between a given clothing system design and a specific wearer performing defined physical tasks is proposed. The modeling framework consists of three interacting modules: (1 a macroscale fabric mechanics/dynamics model; (2 a collision detection and contact correction module; and (3 a human motion module. In the proposed framework, the macroscopic fabric model is based on a rigorous large deformation continuum-degenerated shell theory representation. Material models that capture the stress-strain behavior of different clothing fabrics are used in the continuum shell framework. The collision and contact module enforces the impenetrability constraint between the fabric and human body and computes the associated contact forces between the two. The human body is represented in the current framework as an assemblage of overlapping ellipsoids that undergo rigid body motions consistent with human motions while performing actions such as walking, running, or jumping. The transient rigid body motions of each ellipsoidal body segment in time are determined using motion capture technology. The integrated modeling framework is then exercised to quantify the resistance that the clothing exerts on the wearer during the specific activities under consideration. Current results from the framework are presented and its intended applications are discussed along with some of the key challenges remaining in clothing system modeling.

  16. A Modeling Framework for Conventional and Heat Integrated Distillation Columns

    DEFF Research Database (Denmark)

    Bisgaard, Thomas; Huusom, Jakob Kjøbsted; Abildskov, Jens

    2013-01-01

    In this paper, a generic, modular model framework for describing fluid separation by distillation is presented. At present, the framework is able to describe a conventional distillation column and a heat-integrated distillation column, but due to a modular structure the database can be further ex...

  17. A framework for habitat monitoring and climate change modelling

    NARCIS (Netherlands)

    Villoslada, Miguel; Bunce, Robert G.H.; Sepp, Kalev; Jongman, Rob H.G.; Metzger, Marc J.; Kull, Tiiu; Raet, Janar; Kuusemets, Valdo; Kull, Ain; Leito, Aivar

    2017-01-01

    Environmental stratifications provide the framework for efficient surveillance and monitoring of biodiversity and ecological resources, as well as modelling exercises. An obstacle for agricultural landscape monitoring in Estonia has been the lack of a framework for the objective selection of

  18. A framework for modeling uncertainty in regional climate change

    Science.gov (United States)

    In this study, we present a new modeling framework and a large ensemble of climate projections to investigate the uncertainty in regional climate change over the United States associated with four dimensions of uncertainty. The sources of uncertainty considered in this framework ...

  19. A Framework for Dimensionality Assessment for Multidimensional Item Response Models

    Science.gov (United States)

    Svetina, Dubravka; Levy, Roy

    2014-01-01

    A framework is introduced for considering dimensionality assessment procedures for multidimensional item response models. The framework characterizes procedures in terms of their confirmatory or exploratory approach, parametric or nonparametric assumptions, and applicability to dichotomous, polytomous, and missing data. Popular and emerging…

  20. Generic Model Predictive Control Framework for Advanced Driver Assistance Systems

    NARCIS (Netherlands)

    Wang, M.

    2014-01-01

    This thesis deals with a model predictive control framework for control design of Advanced Driver Assistance Systems, where car-following tasks are under control. The framework is applied to design several autonomous and cooperative controllers and to examine the controller properties at the microsc

  1. Generic Model Predictive Control Framework for Advanced Driver Assistance Systems

    NARCIS (Netherlands)

    Wang, M.

    2014-01-01

    This thesis deals with a model predictive control framework for control design of Advanced Driver Assistance Systems, where car-following tasks are under control. The framework is applied to design several autonomous and cooperative controllers and to examine the controller properties at the microsc

  2. Coastal Ecosystem Integrated Compartment Model (ICM): Modeling Framework

    Science.gov (United States)

    Meselhe, E. A.; White, E. D.; Reed, D.

    2015-12-01

    The Integrated Compartment Model (ICM) was developed as part of the 2017 Coastal Master Plan modeling effort. It is a comprehensive and numerical hydrodynamic model coupled to various geophysical process models. Simplifying assumptions related to some of the flow dynamics are applied to increase the computational efficiency of the model. The model can be used to provide insights about coastal ecosystems and evaluate restoration strategies. It builds on existing tools where possible and incorporates newly developed tools where necessary. It can perform decadal simulations (~ 50 years) across the entire Louisiana coast. It includes several improvements over the approach used to support the 2012 Master Plan, such as: additional processes in the hydrology, vegetation, wetland and barrier island morphology subroutines, increased spatial resolution, and integration of previously disparate models into a single modeling framework. The ICM includes habitat suitability indices (HSIs) to predict broad spatial patterns of habitat change, and it provides an additional integration to a dynamic fish and shellfish community model which quantitatively predicts potential changes in important fishery resources. It can be used to estimate the individual and cumulative effects of restoration and protection projects on the landscape, including a general estimate of water levels associated with flooding. The ICM is also used to examine possible impacts of climate change and future environmental scenarios (e.g. precipitation, Eustatic sea level rise, subsidence, tropical storms, etc.) on the landscape and on the effectiveness of restoration projects. The ICM code is publically accessible, and coastal restoration and protection groups interested in planning-level modeling are encouraged to explore its utility as a computationally efficient tool to examine ecosystem response to future physical or ecological changes, including the implementation of restoration and protection strategies.

  3. Long-term, maintenance MMF monotherapy improves the fibrosis progression in liver transplant recipients with recurrent hepatitis C.

    Science.gov (United States)

    Manzia, Tommaso Maria; Angelico, Roberta; Toti, Luca; Bellini, Maria Irene; Sforza, Daniele; Palmieri, Giampiero; Orlando, Giuseppe; Tariciotti, Laura; Angelico, Mario; Tisone, Giuseppe

    2011-05-01

    Hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (LT) is universal. We designed a retrospective case-control study to evaluate the effect of mycophenolate mofetil (MMF) monotherapy in patients with recurrent hepatitis C. Fifteen patients with histologically proven hepatitis C recurrence after LT were switched from calcineurin inhibitors (CNIs) to MMF monotherapy because of impairment of kidney function and/or metabolic side effects, and treated for 48 months (MMF group). Fifteen well-matched LT recipients who continued to receive CNIs therapy over the same period served as control group. Demographics, clinical data, time after LT, and baseline liver biopsies were similar in the two groups. There was no worsening of hepatic fibrosis during the study in the MMF group [2.6 ± 1.5 (baseline) Ishak Units vs. 2.7 ± 1.8 (after 48 months of MMF treatment), P = 0.6]. In contrast, a significant increase in the fibrosis score [2 ± 1.1 (baseline) vs. 3.2 ± 1.7 (after 48 months of CNI treatment), P = 0.0002] was observed in the control group. The yearly fibrosis progression rate was of 0.05 ± 0.44 in the MMF group and 0.33 ± 0.24 in the CNI group (P = 0.04). MMF monotherapy is associated with a favourable effect on hepatic fibrosis progression in HCV liver transplant recipients.

  4. Conceptualising Business Models: Definitions, Frameworks and Classifications

    Directory of Open Access Journals (Sweden)

    Erwin Fielt

    2013-12-01

    Full Text Available The business model concept is gaining traction in different disciplines but is still criticized for being fuzzy and vague and lacking consensus on its definition and compositional elements. In this paper we set out to advance our understanding of the business model concept by addressing three areas of foundational research: business model definitions, business model elements, and business model archetypes. We define a business model as a representation of the value logic of an organization in terms of how it creates and captures customer value. This abstract and generic definition is made more specific and operational by the compositional elements that need to address the customer, value proposition, organizational architecture (firm and network level and economics dimensions. Business model archetypes complement the definition and elements by providing a more concrete and empirical understanding of the business model concept. The main contributions of this paper are (1 explicitly including the customer value concept in the business model definition and focussing on value creation, (2 presenting four core dimensions that business model elements need to cover, (3 arguing for flexibility by adapting and extending business model elements to cater for different purposes and contexts (e.g. technology, innovation, strategy (4 stressing a more systematic approach to business model archetypes by using business model elements for their description, and (5 suggesting to use business model archetype research for the empirical exploration and testing of business model elements and their relationships.

  5. A conceptual framework for a mentoring model for nurse educators ...

    African Journals Online (AJOL)

    A conceptual framework for a mentoring model for nurse educators. ... recruiting and retaining nurse educators to meet the demands of teaching and learning ... approaches focusing on reasoning strategies, literature control and empirical data ...

  6. Bregman divergence as general framework to estimate unnormalized statistical models

    CERN Document Server

    Gutmann, Michael

    2012-01-01

    We show that the Bregman divergence provides a rich framework to estimate unnormalized statistical models for continuous or discrete random variables, that is, models which do not integrate or sum to one, respectively. We prove that recent estimation methods such as noise-contrastive estimation, ratio matching, and score matching belong to the proposed framework, and explain their interconnection based on supervised learning. Further, we discuss the role of boosting in unsupervised learning.

  7. POSITIVE LEADERSHIP MODELS: THEORETICAL FRAMEWORK AND RESEARCH

    Directory of Open Access Journals (Sweden)

    Javier Blanch, Francisco Gil

    2016-09-01

    Full Text Available The objective of this article is twofold; firstly, we establish the theoretical boundaries of positive leadership and the reasons for its emergence. It is related to the new paradigm of positive psychology that has recently been shaping the scope of organizational knowledge. This conceptual framework has triggered the development of the various forms of positive leadership (i.e. transformational, servant, spiritual, authentic, and positive. Although the construct does not seem univocally defined, these different types of leadership overlap and share a significant affinity. Secondly, we review the empirical evidence that shows the impact of positive leadership in organizations and we highlight the positive relationship between these forms of leadership and key positive organizational variables. Lastly, we analyse future research areas in order to further develop this concept.

  8. An Extensible Model and Analysis Framework

    Science.gov (United States)

    2010-11-01

    for a total of 543 seconds. For comparison purposes, in interpreted mode, opening the model took 224 seconds and running the model took 217 seconds...contains 19683 entities. 9 A comparison of the key model complexity metrics may be found in Table 3. Table 3: Comparison of the model...Triquetrum/RCP supports assembling in arbitrary ways. (12/08 presentation) 2. Prototyped OSGi component architecture for use with Netbeans and

  9. A Simulation and Modeling Framework for Space Situational Awareness

    Science.gov (United States)

    Olivier, S.

    This paper describes the development and initial demonstration of a new, integrated modeling and simulation framework, encompassing the space situational awareness enterprise, for quantitatively assessing the benefit of specific sensor systems, technologies and data analysis techniques. This framework includes detailed models for threat scenarios, signatures, sensors, observables and knowledge extraction algorithms. The framework is based on a flexible, scalable architecture to enable efficient simulation of the current SSA enterprise, and to accommodate future advancements in SSA systems. In particular, the code is designed to take advantage of massively parallel computer systems available, for example, at Lawrence Livermore National Laboratory. We will describe the details of the modeling and simulation framework, including hydrodynamic models of satellite intercept and debris generation, orbital propagation algorithms, radar cross section calculations, optical and infra-red brightness calculations, generic radar system models, generic optical and infra-red system models, specific Space Surveillance Network models, object detection algorithms, orbit determination algorithms, and visualization tools. The specific modeling of the Space Surveillance Network is performed in collaboration with the Air Force Space Command Space Control Group. We will demonstrate the use of this integrated simulation and modeling framework on specific threat scenarios, including space debris and satellite maneuvers, and we will examine the results of case studies involving the addition of new sensor systems, used in conjunction with the Space Surveillance Network, for improving space situational awareness.

  10. An Ising model for metal-organic frameworks

    Science.gov (United States)

    Höft, Nicolas; Horbach, Jürgen; Martín-Mayor, Victor; Seoane, Beatriz

    2017-08-01

    We present a three-dimensional Ising model where lines of equal spins are frozen such that they form an ordered framework structure. The frame spins impose an external field on the rest of the spins (active spins). We demonstrate that this "porous Ising model" can be seen as a minimal model for condensation transitions of gas molecules in metal-organic frameworks. Using Monte Carlo simulation techniques, we compare the phase behavior of a porous Ising model with that of a particle-based model for the condensation of methane (CH4) in the isoreticular metal-organic framework IRMOF-16. For both models, we find a line of first-order phase transitions that end in a critical point. We show that the critical behavior in both cases belongs to the 3D Ising universality class, in contrast to other phase transitions in confinement such as capillary condensation.

  11. Mediation Analysis in a Latent Growth Curve Modeling Framework

    Science.gov (United States)

    von Soest, Tilmann; Hagtvet, Knut A.

    2011-01-01

    This article presents several longitudinal mediation models in the framework of latent growth curve modeling and provides a detailed account of how such models can be constructed. Logical and statistical challenges that might arise when such analyses are conducted are also discussed. Specifically, we discuss how the initial status (intercept) and…

  12. A DSM-based framework for integrated function modelling

    DEFF Research Database (Denmark)

    Eisenbart, Boris; Gericke, Kilian; Blessing, Lucienne T. M.

    2017-01-01

    an integrated function modelling framework, which specifically aims at relating between the different function modelling perspectives prominently addressed in different disciplines. It uses interlinked matrices based on the concept of DSM and MDM in order to facilitate cross-disciplinary modelling and analysis...

  13. Threat model framework and methodology for personal networks (PNs)

    DEFF Research Database (Denmark)

    Prasad, Neeli R.

    2007-01-01

    is to give a structured, convenient approach for building threat models. A framework for the threat model is presented with a list of requirements for methodology. The methodology will be applied to build a threat model for Personal Networks. Practical tools like UML sequence diagrams and attack trees have...

  14. MODELS FOR NETWORK DYNAMICS - A MARKOVIAN FRAMEWORK

    NARCIS (Netherlands)

    LEENDERS, RTAJ

    1995-01-01

    A question not very often addressed in social network analysis relates to network dynamics and focuses on how networks arise and change. It alludes to the idea that ties do not arise or vanish randomly, but (partly) as a consequence of human behavior and preferences. Statistical models for modeling

  15. A Computational Framework for Realistic Retina Modeling.

    Science.gov (United States)

    Martínez-Cañada, Pablo; Morillas, Christian; Pino, Begoña; Ros, Eduardo; Pelayo, Francisco

    2016-11-01

    Computational simulations of the retina have led to valuable insights about the biophysics of its neuronal activity and processing principles. A great number of retina models have been proposed to reproduce the behavioral diversity of the different visual processing pathways. While many of these models share common computational stages, previous efforts have been more focused on fitting specific retina functions rather than generalizing them beyond a particular model. Here, we define a set of computational retinal microcircuits that can be used as basic building blocks for the modeling of different retina mechanisms. To validate the hypothesis that similar processing structures may be repeatedly found in different retina functions, we implemented a series of retina models simply by combining these computational retinal microcircuits. Accuracy of the retina models for capturing neural behavior was assessed by fitting published electrophysiological recordings that characterize some of the best-known phenomena observed in the retina: adaptation to the mean light intensity and temporal contrast, and differential motion sensitivity. The retinal microcircuits are part of a new software platform for efficient computational retina modeling from single-cell to large-scale levels. It includes an interface with spiking neural networks that allows simulation of the spiking response of ganglion cells and integration with models of higher visual areas.

  16. GeoFramework: Coupling multiple models of mantle convection within a computational framework

    Science.gov (United States)

    Tan, E.; Choi, E.; Thoutireddy, P.; Gurnis, M.; Aivazis, M.

    2004-12-01

    Geological processes usually encompass a broad spectrum of length and time scales. Traditionally, a modeling code (solver) is developed for a problem of specific length and time scales, but the utility of the solver beyond the designated purpose is usually limited. As we have come to recognize that geological processes often result from the dynamic coupling of deformation across a wide range of time and spatial scales, more robust methods are needed. One means to address this need is through the integration of complementary modeling codes, while attempting to reuse existing software as much as possible. The GeoFramework project addresses this by developing a suite of reusable and combinable tools for the Earth science community. GeoFramework is based on and extends Pyre, a Python-based modeling framework, developed to link solid (Lagrangian) and fluid (Eulerian) solvers, as well as mesh generators, visualization packages, and databases, with one another for engineering applications. Under the framework, a solver is aware of the presence of other solvers and can interact with each other via exchanging information across adjacent mesh boundary. We will show an example of linking two instances of the CitcomS finite element solver within GeoFramework. A high-resolution regional mantle convection model is linked with a global mantle convection model. The global solver has a resolution of ˜180 km horizontally and 35-100 km (with mesh refinement) vertically. The fine mesh has a resolution of ˜40 km horizontally and vertically. The fine mesh is center on the Hawaii hotspot. A vertical plume is used as an initial condition. Time-varying plate velocity models are imposed since 80 Ma and we have investigated how the plume conduit is deflected by the global circulation patterns as a function of mantle viscosity, plume flux, and plate motion.

  17. Multilevel Models: Conceptual Framework and Applicability

    Directory of Open Access Journals (Sweden)

    Roxana-Otilia-Sonia Hrițcu

    2015-10-01

    Full Text Available Individuals and the social or organizational groups they belong to can be viewed as a hierarchical system situated on different levels. Individuals are situated on the first level of the hierarchy and they are nested together on the higher levels. Individuals interact with the social groups they belong to and are influenced by these groups. Traditional methods that study the relationships between data, like simple regression, do not take into account the hierarchical structure of the data and the effects of a group membership and, hence, results may be invalidated. Unlike standard regression modelling, the multilevel approach takes into account the individuals as well as the groups to which they belong. To take advantage of the multilevel analysis it is important that we recognize the multilevel characteristics of the data. In this article we introduce the outlines of multilevel data and we describe the models that work with such data. We introduce the basic multilevel model, the two-level model: students can be nested into classes, individuals into countries and the general two-level model can be extended very easily to several levels. Multilevel analysis has begun to be extensively used in many research areas. We present the most frequent study areas where multilevel models are used, such as sociological studies, education, psychological research, health studies, demography, epidemiology, biology, environmental studies and entrepreneurship. We support the idea that since hierarchies exist everywhere, multilevel data should be recognized and analyzed properly by using multilevel modelling.

  18. Traffic modelling framework for electric vehicles

    Science.gov (United States)

    Schlote, Arieh; Crisostomi, Emanuele; Kirkland, Stephen; Shorten, Robert

    2012-07-01

    This article reviews and improves a recently proposed model of road network dynamics. The model is also adapted and generalised to represent the patterns of battery consumption of electric vehicles travelling in the road network. Simulations from the mobility simulator SUMO are given to support and to illustrate the efficacy of the proposed approach. Applications relevant in the field of electric vehicles, such as optimal routing and traffic load control, are provided to illustrate how the proposed model can be used to address typical problems arising in contemporary road network planning and electric vehicle mobility.

  19. TRANSFORM - TRANsient Simulation Framework of Reconfigurable Models

    Energy Technology Data Exchange (ETDEWEB)

    2017-09-01

    Existing development tools for early stage design and scoping of energy systems are often time consuming to use, proprietary, and do not contain the necessary function to model complete systems (i.e., controls, primary, and secondary systems) in a common platform. The Modelica programming language based TRANSFORM tool (1) provides a standardized, common simulation environment for early design of energy systems (i.e., power plants), (2) provides a library of baseline component modules to be assembled into full plant models using available geometry, design, and thermal-hydraulic data, (3) defines modeling conventions for interconnecting component models, and (4) establishes user interfaces and support tools to facilitate simulation development (i.e., configuration and parameterization), execution, and results display and capture.

  20. Fisher Information Framework for Time Series Modeling

    CERN Document Server

    Venkatesan, R C

    2016-01-01

    A robust prediction model invoking the Takens embedding theorem, whose \\textit{working hypothesis} is obtained via an inference procedure based on the minimum Fisher information principle, is presented. The coefficients of the ansatz, central to the \\textit{working hypothesis} satisfy a time independent Schr\\"{o}dinger-like equation in a vector setting. The inference of i) the probability density function of the coefficients of the \\textit{working hypothesis} and ii) the establishing of constraint driven pseudo-inverse condition for the modeling phase of the prediction scheme, is made, for the case of normal distributions, with the aid of the quantum mechanical virial theorem. The well-known reciprocity relations and the associated Legendre transform structure for the Fisher information measure (FIM, hereafter)-based model in a vector setting (with least square constraints) are self-consistently derived. These relations are demonstrated to yield an intriguing form of the FIM for the modeling phase, which defi...

  1. A Modeling Framework for Gossip-based Information Spread

    CERN Document Server

    Bakhshi, Rena; Fokkink, Wan; van Steen, Maarten

    2011-01-01

    We present an analytical framework for gossip protocols based on the pairwise information exchange between interacting nodes. This framework allows for studying the impact of protocol parameters on the performance of the protocol. Previously, gossip-based information dissemination protocols have been analyzed under the assumption of perfect, lossless communication channels. We extend our framework for the analysis of networks with lossy channels. We show how the presence of message loss, coupled with specific topology configurations,impacts the expected behavior of the protocol. We validate the obtained models against simulations for two protocols.

  2. Severe insulin resistance secondary to insulin antibodies: successful treatment with the immunosuppressant MMF.

    Science.gov (United States)

    Segal, T; Webb, Ea; Viner, R; Pusey, C; Wild, G; Allgrove, J

    2008-06-01

    We have evaluated the use of the immunosuppressant mycophenolate mofetil (MMF) in the treatment of severe insulin resistance caused by neutralising anti-insulin antibodies in type 1 diabetes mellitus (T1DM). A 12-yr-old boy with a 5-month history of T1DM developed severe immunological insulin resistance secondary to human insulin antibodies. Various different treatment modalities, including lispro insulin, intravenous insulin, prednisolone and immunoabsorption, were tried, all without a sustained response to treatment. Although the introduction of the immunosuppressant MMF only resulted in a small reduction in haemoglobin A1c (from 10.9 to 9.8%), it did result in a significant reduction in insulin requirements from 6000 to 250 U/d (75 to 3.1 U/kg/d), disappearance of the severe nocturnal hypoglycaemia associated with high titres of insulin antibodies and a reduction in the level of these antibodies from 34.6 to 2.7 mg/dL. MMF may be considered as a means of immunosuppression in patients with markedly raised insulin antibodies whose diabetes cannot be controlled with insulin alone.

  3. The effect of MMF dose and trough levels on adverse effects in pediatric heart transplant recipients.

    Science.gov (United States)

    Siddiqi, Nida; Lamour, Jacqueline M; Hsu, Daphne T

    2015-09-01

    Limited pharmacokinetic and safety data exist for MMF in pediatric HTR. Previously targeted MPA-TL are 1.5-3.0 μg/mL. The objective of this study was to assess the outcomes targeting MPA-TL of 0.8-2.0 μg/mL in pediatric HTR. MPA-TL were retrospectively collected 2-12 months post-transplant. Acute rejection, infection, leukopenia, and GI complaints were then correlated with MPA-TL. A total of 355 MPA-TL from 22 HTR were included. Median age was 2.5 yr. Primary indication for transplant was dilated cardiomyopathy (64%). Mean MPA-TL was 1.7 ± 0.9 μg/mL. African American patients received significantly higher doses (702 ± 235 mg/m(2) ) compared with other races (p = 0.035). Leukopenia was less common in patients with SUB MPA vs. others (p = 0.01). MMF was discontinued for GI complaints in one patient and leukopenia in two patients. One SUB patient had acute rejection, and one SUP patient had infection. One-yr survival was 100%. Targeting a lower range for MPA-TL was not associated with significant rejection or infection. Despite lower MPA-TL, MMF was discontinued in 3/22 patients for adverse effects.

  4. TCF-MMF-TCF fiber structure based interferometer for refractive index sensing

    Science.gov (United States)

    Fu, Haiwei; Li, Huidong; Shao, Min; Zhao, Na; Liu, Yinggang; Li, Yan; Yan, Xu; Liu, Qinpeng

    2015-06-01

    A liquid refractive index (RI) sensor based on in-fiber Mach-Zehnder interferometer (MZI) by sandwiching multi-mode fiber (MMF) between two short sections of thinned core fiber (TCF) is proposed in this paper. The first section of TCF excites the high-order modes and the second section TCF couples the core mode and high-order modes into lead-out SMF to form intermodal interference. The sensor with MMF length of 20 mm and TCFs length of 1 mm was fabricated. The transmission spectrum variation of the sensor with respect to surrounding refractive index (SRI) has been studied by experiment. The results show that the central wavelength of dips/peaks shifting had a good linearity with SRI. The RI sensitivity of the sensor is 130.00 nm/RIU over the RI range of 1.3333-1.4182. The RI sensitivity increase to 433.60 nm/RIU after etching the MMF cladding of the sensor. The sensor keeps low dependence on temperature before and after etching.

  5. Pediatric pemphigus vulgaris: durable treatment responses achieved with prednisone and mycophenolate mofetil (MMF).

    Science.gov (United States)

    Baratta, Andrea; Camarillo, Diana; Papa, Christine; Treat, James R; Payne, Aimee S; Rozenber, Suzanne S; Yan, Albert C

    2013-01-01

    Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease of the skin and mucous membranes. Most cases occur in adults; cases in children are rare. This report describes the clinical presentations and treatment responses of three children with PV, as confirmed according to histology and indirect immunofluorescence studies. In all three cases, oral prednisone used in conjunction with mycophenolate mofetil (MMF) resulted in complete clinical remission, during which all pharmacotherapy was successfully discontinued. Resolution of the skin and mucosal blistering tended to occur quickly with prednisone, and after initiation of treatment with MMF, discontinuation of all pharmacotherapy was achieved within a range of 10 to 30 months in the three patients. One patient experienced a recurrence of genital lesions 19 months after discontinuation of therapy, but the condition remitted within 2 weeks with topical corticosteroid therapy. At the time of this report, the duration of complete remission ranged from 6 to 19 months. In summary, combination therapy with prednisone and MMF for pediatric PV appears to be a safe and effective approach that is associated with durable remission.

  6. Multicriteria framework for selecting a process modelling language

    Science.gov (United States)

    Scanavachi Moreira Campos, Ana Carolina; Teixeira de Almeida, Adiel

    2016-01-01

    The choice of process modelling language can affect business process management (BPM) since each modelling language shows different features of a given process and may limit the ways in which a process can be described and analysed. However, choosing the appropriate modelling language for process modelling has become a difficult task because of the availability of a large number modelling languages and also due to the lack of guidelines on evaluating, and comparing languages so as to assist in selecting the most appropriate one. This paper proposes a framework for selecting a modelling language in accordance with the purposes of modelling. This framework is based on the semiotic quality framework (SEQUAL) for evaluating process modelling languages and a multicriteria decision aid (MCDA) approach in order to select the most appropriate language for BPM. This study does not attempt to set out new forms of assessment and evaluation criteria, but does attempt to demonstrate how two existing approaches can be combined so as to solve the problem of selection of modelling language. The framework is described in this paper and then demonstrated by means of an example. Finally, the advantages and disadvantages of using SEQUAL and MCDA in an integrated manner are discussed.

  7. Long-term renal allograft function on a tacrolimus-based, pred-free maintenance immunosuppression comparing sirolimus vs. MMF.

    Science.gov (United States)

    Gallon, L; Perico, N; Dimitrov, B D; Winoto, J; Remuzzi, G; Leventhal, J; Gaspari, F; Kaufman, D

    2006-07-01

    It is not known how different steroid-free immunosuppressive combinations affect renal graft survival and long-term kidney transplant function. Here we sought to compare the impact on graft survival and long-term graft function of two tacrolimus (Tac)-based, prednisone-free maintenance immunosuppressive protocols: Tac/Mycophenolate Mofetil (MMF) vs. Tac/Sirolimus (SRL). Renal transplant patients given induction therapy with IL2-RA and methylprednisolone on days 0, 1 and 2 post-transplant were prospectively randomized to two maintenance immunosuppressive regimens with Tac/MMF (n = 45) or Tac/SRL (n = 37). During the 3-year follow-up the following data were collected: patient survival, renal allograft survival, incidence of acute rejection and glomerular filtration rate (GFR) at different time-points post-transplant. Cumulative graft survival was significantly different in the two groups: one kidney loss in the Tac/MMF vs. six kidney losses in the Tac/SRL (log-rank test p = 0.04). GFR at different time-points post-transplant was consistently and statistically better in the Tac/MMF than in the Tac/SRL group. The slope of GFR decline per month was flatter in the Tac/MMF than in the Tac/SRL group. This study showed that renal graft survival and graft function were significantly lower in the combination of Tac/SRL than Tac/MMF.

  8. Theoretical Tinnitus framework: A Neurofunctional Model

    Directory of Open Access Journals (Sweden)

    Iman Ghodratitoostani

    2016-08-01

    Full Text Available Subjective tinnitus is the conscious (attended awareness perception of sound in the absence of an external source and can be classified as an auditory phantom perception. The current tinnitus development models depend on the role of external events congruently paired with the causal physical events that precipitate the phantom perception. We propose a novel Neurofunctional tinnitus model to indicate that the conscious perception of phantom sound is essential in activating the cognitive-emotional value. The cognitive-emotional value plays a crucial role in governing attention allocation as well as developing annoyance within tinnitus clinical distress. Structurally, the Neurofunctional tinnitus model includes the peripheral auditory system, the thalamus, the limbic system, brain stem, basal ganglia, striatum and the auditory along with prefrontal cortices. Functionally, we assume the model includes presence of continuous or intermittent abnormal signals at the peripheral auditory system or midbrain auditory paths. Depending on the availability of attentional resources, the signals may or may not be perceived. The cognitive valuation process strengthens the lateral-inhibition and noise canceling mechanisms in the mid-brain, which leads to the cessation of sound perception and renders the signal evaluation irrelevant. However, the sourceless sound is eventually perceived and can be cognitively interpreted as suspicious or an indication of a disease in which the cortical top-down processes weaken the noise canceling effects. This results in an increase in cognitive and emotional negative reactions such as depression and anxiety. The negative or positive cognitive-emotional feedbacks within the top-down approach may have no relation to the previous experience of the patients. They can also be associated with aversive stimuli similar to abnormal neural activity in generating the phantom sound. Cognitive and emotional reactions depend on general

  9. Theoretical Tinnitus Framework: A Neurofunctional Model.

    Science.gov (United States)

    Ghodratitoostani, Iman; Zana, Yossi; Delbem, Alexandre C B; Sani, Siamak S; Ekhtiari, Hamed; Sanchez, Tanit G

    2016-01-01

    Subjective tinnitus is the conscious (attended) awareness perception of sound in the absence of an external source and can be classified as an auditory phantom perception. Earlier literature establishes three distinct states of conscious perception as unattended, attended, and attended awareness conscious perception. The current tinnitus development models depend on the role of external events congruently paired with the causal physical events that precipitate the phantom perception. We propose a novel Neurofunctional Tinnitus Model to indicate that the conscious (attended) awareness perception of phantom sound is essential in activating the cognitive-emotional value. The cognitive-emotional value plays a crucial role in governing attention allocation as well as developing annoyance within tinnitus clinical distress. Structurally, the Neurofunctional Tinnitus Model includes the peripheral auditory system, the thalamus, the limbic system, brainstem, basal ganglia, striatum, and the auditory along with prefrontal cortices. Functionally, we assume the model includes presence of continuous or intermittent abnormal signals at the peripheral auditory system or midbrain auditory paths. Depending on the availability of attentional resources, the signals may or may not be perceived. The cognitive valuation process strengthens the lateral-inhibition and noise canceling mechanisms in the mid-brain, which leads to the cessation of sound perception and renders the signal evaluation irrelevant. However, the "sourceless" sound is eventually perceived and can be cognitively interpreted as suspicious or an indication of a disease in which the cortical top-down processes weaken the noise canceling effects. This results in an increase in cognitive and emotional negative reactions such as depression and anxiety. The negative or positive cognitive-emotional feedbacks within the top-down approach may have no relation to the previous experience of the patients. They can also be

  10. A community-based framework for aquatic ecosystem models

    DEFF Research Database (Denmark)

    Trolle, Didde; Hamilton, D. P.; Hipsey, M. R.;

    2012-01-01

    aim to (i) advance collaboration within the aquatic ecosystem modelling community, (ii) enable increased use of models for research, policy and ecosystem-based management, (iii) facilitate a collective framework using common (standardised) code to ensure that model development is incremental, (iv......Here, we communicate a point of departure in the development of aquatic ecosystem models, namely a new community-based framework, which supports an enhanced and transparent union between the collective expertise that exists in the communities of traditional ecologists and model developers. Through...... a literature survey, we document the growing importance of numerical aquatic ecosystem models while also noting the difficulties, up until now, of the aquatic scientific community to make significant advances in these models during the past two decades. Through a common forum for aquatic ecosystem modellers we...

  11. A framework for quantifying net benefits of alternative prognostic models

    DEFF Research Database (Denmark)

    Rapsomaniki, Eleni; White, Ian R; Wood, Angela M

    2012-01-01

    New prognostic models are traditionally evaluated using measures of discrimination and risk reclassification, but these do not take full account of the clinical and health economic context. We propose a framework for comparing prognostic models by quantifying the public health impact (net benefit...

  12. Industrial Sector Energy Efficiency Modeling (ISEEM) Framework Documentation

    Energy Technology Data Exchange (ETDEWEB)

    Karali, Nihan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Xu, Tengfang [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sathaye, Jayant [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-12-12

    The goal of this study is to develop a new bottom-up industry sector energy-modeling framework with an agenda of addressing least cost regional and global carbon reduction strategies, improving the capabilities and limitations of the existing models that allows trading across regions and countries as an alternative.

  13. A framework for quantifying net benefits of alternative prognostic models

    NARCIS (Netherlands)

    Rapsomaniki, Eleni; White, Ian R.; Wood, Angela M.; Thompson, Simon G.

    2012-01-01

    New prognostic models are traditionally evaluated using measures of discrimination and risk reclassification, but these do not take full account of the clinical and health economic context. We propose a framework for comparing prognostic models by quantifying the public health impact (net benefit) o

  14. Conceptual Frameworks and Research Models on Resilience in Leadership

    OpenAIRE

    Janet Ledesma

    2014-01-01

    The purpose of this article was to discuss conceptual frameworks and research models on resilience theory. The constructs of resilience, the history of resilience theory, models of resilience, variables of resilience, career resilience, and organizational resilience will be examined and discussed as they relate to leadership development. The literature demonstrates that there is a direct relationship between the stress...

  15. A National Modeling Framework for Water Management Decisions

    Science.gov (United States)

    Bales, J. D.; Cline, D. W.; Pietrowsky, R.

    2013-12-01

    The National Weather Service (NWS), the U.S. Army Corps of Engineers (USACE), and the U.S. Geological Survey (USGS), all Federal agencies with complementary water-resources activities, entered into an Interagency Memorandum of Understanding (MOU) "Collaborative Science Services and Tools to Support Integrated and Adaptive Water Resources Management" to collaborate in activities that are supportive to their respective missions. One of the interagency activities is the development of a highly integrated national water modeling framework and information services framework. Together these frameworks establish a common operating picture, improve modeling and synthesis, support the sharing of data and products among agencies, and provide a platform for incorporation of new scientific understanding. Each of the agencies has existing operational systems to assist in carrying out their respective missions. The systems generally are designed, developed, tested, fielded, and supported by specialized teams. A broader, shared approach is envisioned and would include community modeling, wherein multiple independent investigators or teams develop and contribute new modeling capabilities based on science advances; modern technology in coupling model components and visualizing results; and a coupled atmospheric - hydrologic model construct such that the framework could be used in real-time water-resources decision making or for long-term management decisions. The framework also is being developed to account for organizational structures of the three partners such that, for example, national data sets can move down to the regional scale, and vice versa. We envision the national water modeling framework to be an important element of North American Water Program, to contribute to goals of the Program, and to be informed by the science and approaches developed as a part of the Program.

  16. The Guided System Development Framework: Modeling and Verifying Communication Systems

    DEFF Research Database (Denmark)

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.; Nielson, Flemming

    2014-01-01

    In a world that increasingly relies on the Internet to function, application developers rely on the implementations of protocols to guarantee the security of data transferred. Whether a chosen protocol gives the required guarantees, and whether the implementation does the same, is usually unclear....... The Guided System Development framework contributes to more secure communication systems by aiding the development of such systems. The framework features a simple modelling language, step-wise refinement from models to implementation, interfaces to security verification tools, and code generation from...

  17. GEMFsim: A Stochastic Simulator for the Generalized Epidemic Modeling Framework

    CERN Document Server

    Sahneh, Faryad Darabi; Shakeri, Heman; Fan, Futing; Scoglio, Caterina

    2016-01-01

    The recently proposed generalized epidemic modeling framework (GEMF) \\cite{sahneh2013generalized} lays the groundwork for systematically constructing a broad spectrum of stochastic spreading processes over complex networks. This article builds an algorithm for exact, continuous-time numerical simulation of GEMF-based processes. Moreover the implementation of this algorithm, GEMFsim, is available in popular scientific programming platforms such as MATLAB, R, Python, and C; GEMFsim facilitates simulating stochastic spreading models that fit in GEMF framework. Using these simulations one can examine the accuracy of mean-field-type approximations that are commonly used for analytical study of spreading processes on complex networks.

  18. A software engineering perspective on environmental modeling framework design: The object modeling system

    Science.gov (United States)

    The environmental modeling community has historically been concerned with the proliferation of models and the effort associated with collective model development tasks (e.g., code generation, data provisioning and transformation, etc.). Environmental modeling frameworks (EMFs) have been developed to...

  19. A Bayesian framework for parameter estimation in dynamical models.

    Directory of Open Access Journals (Sweden)

    Flávio Codeço Coelho

    Full Text Available Mathematical models in biology are powerful tools for the study and exploration of complex dynamics. Nevertheless, bringing theoretical results to an agreement with experimental observations involves acknowledging a great deal of uncertainty intrinsic to our theoretical representation of a real system. Proper handling of such uncertainties is key to the successful usage of models to predict experimental or field observations. This problem has been addressed over the years by many tools for model calibration and parameter estimation. In this article we present a general framework for uncertainty analysis and parameter estimation that is designed to handle uncertainties associated with the modeling of dynamic biological systems while remaining agnostic as to the type of model used. We apply the framework to fit an SIR-like influenza transmission model to 7 years of incidence data in three European countries: Belgium, the Netherlands and Portugal.

  20. ECoS, a framework for modelling hierarchical spatial systems.

    Science.gov (United States)

    Harris, John R W; Gorley, Ray N

    2003-10-01

    A general framework for modelling hierarchical spatial systems has been developed and implemented as the ECoS3 software package. The structure of this framework is described, and illustrated with representative examples. It allows the set-up and integration of sets of advection-diffusion equations representing multiple constituents interacting in a spatial context. Multiple spaces can be defined, with zero, one or two-dimensions and can be nested, and linked through constituent transfers. Model structure is generally object-oriented and hierarchical, reflecting the natural relations within its real-world analogue. Velocities, dispersions and inter-constituent transfers, together with additional functions, are defined as properties of constituents to which they apply. The resulting modular structure of ECoS models facilitates cut and paste model development, and template model components have been developed for the assembly of a range of estuarine water quality models. Published examples of applications to the geochemical dynamics of estuaries are listed.

  1. A unified framework for Schelling's model of segregation

    CERN Document Server

    Rogers, Tim

    2011-01-01

    Schelling's model of segregation is one of the first and most influential models in the field of social simulation. There are many variations of the model which have been proposed and simulated over the last forty years, though the present state of the literature on the subject is somewhat fragmented and lacking comprehensive analytical treatments. In this article a unified mathematical framework for Schelling's model and its many variants is developed. This methodology is useful in two regards: firstly, it provides a tool with which to understand the differences observed between models; secondly, phenomena which appear in several model variations may be understood in more depth through analytic studies of simpler versions.

  2. A unified framework for Schelling's model of segregation

    Science.gov (United States)

    Rogers, Tim; McKane, Alan J.

    2011-07-01

    Schelling's model of segregation is one of the first and most influential models in the field of social simulation. There are many variations of the model which have been proposed and simulated over the last forty years, though the present state of the literature on the subject is somewhat fragmented and lacking comprehensive analytical treatments. In this paper a unified mathematical framework for Schelling's model and its many variants is developed. This methodology is useful in two regards: firstly, it provides a tool with which to understand the differences observed between models; secondly, phenomena which appear in several model variations may be understood in more depth through analytic studies of simpler versions.

  3. 3D Building Model Fitting Using A New Kinetic Framework

    CERN Document Server

    Brédif, Mathieu; Pierrot-Deseilligny, Marc; Maître, Henri

    2008-01-01

    We describe a new approach to fit the polyhedron describing a 3D building model to the point cloud of a Digital Elevation Model (DEM). We introduce a new kinetic framework that hides to its user the combinatorial complexity of determining or maintaining the polyhedron topology, allowing the design of a simple variational optimization. This new kinetic framework allows the manipulation of a bounded polyhedron with simple faces by specifying the target plane equations of each of its faces. It proceeds by evolving continuously from the polyhedron defined by its initial topology and its initial plane equations to a polyhedron that is as topologically close as possible to the initial polyhedron but with the new plane equations. This kinetic framework handles internally the necessary topological changes that may be required to keep the faces simple and the polyhedron bounded. For each intermediate configurations where the polyhedron looses the simplicity of its faces or its boundedness, the simplest topological mod...

  4. New framework for standardized notation in wastewater treatment modelling

    DEFF Research Database (Denmark)

    Corominas, L.; Rieger, L.; Takacs, I.

    2010-01-01

    is a framework that can be used in whole plant modelling, which consists of different fields such as activated sludge, anaerobic digestion, sidestream treatment, membrane bioreactors, metabolic approaches, fate of micropollutants and biofilm processes. The main objective of this consensus building paper...... notational framework which allows unique and systematic naming of state variables and parameters of biokinetic models in the wastewater treatment field. The symbols are based on one main letter that gives a general description of the state variable or parameter and several subscript levels that provide......Many unit process models are available in the field of wastewater treatment. All of these models use their own notation, causing problems for documentation, implementation and connection of different models (using different sets of state variables). The main goal of this paper is to propose a new...

  5. A Liver-Centric Multiscale Modeling Framework for Xenobiotics

    Science.gov (United States)

    Swat, Maciej; Cosmanescu, Alin; Clendenon, Sherry G.; Wambaugh, John F.; Glazier, James A.

    2016-01-01

    We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metabolism. We do this by incorporating sub-models that span three scales; Physiologically Based Pharmacokinetic (PBPK) modeling of acetaminophen uptake and distribution at the whole body level, cell and blood flow modeling at the tissue/organ level and metabolism at the sub-cellular level. We have used standard modeling modalities at each of the three scales. In particular, we have used the Systems Biology Markup Language (SBML) to create both the whole-body and sub-cellular scales. Our modeling approach allows us to run the individual sub-models separately and allows us to easily exchange models at a particular scale without the need to extensively rework the sub-models at other scales. In addition, the use of SBML greatly facilitates the inclusion of biological annotations directly in the model code. The model was calibrated using human in vivo data for acetaminophen and its sulfate and glucuronate metabolites. We then carried out extensive parameter sensitivity studies including the pairwise interaction of parameters. We also simulated population variation of exposure and sensitivity to acetaminophen. Our modeling framework can be extended to the prediction of liver toxicity following acetaminophen overdose, or used as a general purpose pharmacokinetic model for xenobiotics. PMID:27636091

  6. New framework for standardized notation in wastewater treatment modelling.

    Science.gov (United States)

    Corominas, L L; Rieger, L; Takács, I; Ekama, G; Hauduc, H; Vanrolleghem, P A; Oehmen, A; Gernaey, K V; van Loosdrecht, M C M; Comeau, Y

    2010-01-01

    Many unit process models are available in the field of wastewater treatment. All of these models use their own notation, causing problems for documentation, implementation and connection of different models (using different sets of state variables). The main goal of this paper is to propose a new notational framework which allows unique and systematic naming of state variables and parameters of biokinetic models in the wastewater treatment field. The symbols are based on one main letter that gives a general description of the state variable or parameter and several subscript levels that provide greater specification. Only those levels that make the name unique within the model context are needed in creating the symbol. The paper describes specific problems encountered with the currently used notation, presents the proposed framework and provides additional practical examples. The overall result is a framework that can be used in whole plant modelling, which consists of different fields such as activated sludge, anaerobic digestion, sidestream treatment, membrane bioreactors, metabolic approaches, fate of micropollutants and biofilm processes. The main objective of this consensus building paper is to establish a consistent set of rules that can be applied to existing and most importantly, future models. Applying the proposed notation should make it easier for everyone active in the wastewater treatment field to read, write and review documents describing modelling projects.

  7. A computational framework for a database of terrestrial biosphere models

    Science.gov (United States)

    Metzler, Holger; Müller, Markus; Ceballos-Núñez, Verónika; Sierra, Carlos A.

    2016-04-01

    Most terrestrial biosphere models consist of a set of coupled ordinary first order differential equations. Each equation represents a pool containing carbon with a certain turnover rate. Although such models share some basic mathematical structures, they can have very different properties such as number of pools, cycling rates, and internal fluxes. We present a computational framework that helps analyze the structure and behavior of terrestrial biosphere models using as an example the process of soil organic matter decomposition. The same framework can also be used for other sub-processes such as carbon fixation or allocation. First, the models have to be fed into a database consisting of simple text files with a common structure. Then they are read in using Python and transformed into an internal 'Model Class' that can be used to automatically create an overview stating the model's structure, state variables, internal and external fluxes. SymPy, a Python library for symbolic mathematics, helps to also calculate the Jacobian matrix at possibly given steady states and the eigenvalues of this matrix. If complete parameter sets are available, the model can also be run using R to simulate its behavior under certain conditions and to support a deeper stability analysis. In this case, the framework is also able to provide phase-plane plots if appropriate. Furthermore, an overview of all the models in the database can be given to help identify their similarities and differences.

  8. Service business model framework and the service innovation scope

    NARCIS (Netherlands)

    van der Aa, W.; van der Rhee, B.; Victorino, L.

    2011-01-01

    In this paper we present a framework for service business models. We build on three streams of research. The first stream is the service management and marketing literature that focuses on the specific challenges of managing a service business. The second stream consists of research on e-business

  9. Designing for Learning and Play - The Smiley Model as Framework

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke

    2016-01-01

    This paper presents a framework for designing engaging learning experiences in games – the Smiley Model. In this Design-Based Research project, student-game-designers were learning inside a gamified learning design - while designing and implementing learning goals from curriculum into the small d...

  10. The BMW Model: A New Framework for Teaching Monetary Economics

    Science.gov (United States)

    Bofinger, Peter; Mayer, Eric; Wollmershauser, Timo

    2006-01-01

    Although the IS/LM-AS/AD model is still the central tool of macroeconomic teaching in most macroeconomic textbooks, it has been criticized by several economists. Colander (1995) demonstrated that the framework is logically inconsistent, Romer (2000) showed that it is unable to deal with a monetary policy that uses the interest rate as its…

  11. A compositional modelling framework for exploring MPSoC systems

    DEFF Research Database (Denmark)

    Tranberg-Hansen, Anders Sejer; Madsen, Jan

    2009-01-01

    This paper presents a novel compositional framework for system level performance estimation and exploration of Multi-Processor System On Chip (MPSoC) based systems. The main contributions are the definition of a compositional model which allows quantitative performance estimation to be carried ou...

  12. A Model-Driven Framework to Develop Personalized Health Monitoring

    Directory of Open Access Journals (Sweden)

    Algimantas Venčkauskas

    2016-07-01

    Full Text Available Both distributed healthcare systems and the Internet of Things (IoT are currently hot topics. The latter is a new computing paradigm to enable advanced capabilities in engineering various applications, including those for healthcare. For such systems, the core social requirement is the privacy/security of the patient information along with the technical requirements (e.g., energy consumption and capabilities for adaptability and personalization. Typically, the functionality of the systems is predefined by the patient’s data collected using sensor networks along with medical instrumentation; then, the data is transferred through the Internet for treatment and decision-making. Therefore, systems creation is indeed challenging. In this paper, we propose a model-driven framework to develop the IoT-based prototype and its reference architecture for personalized health monitoring (PHM applications. The framework contains a multi-layered structure with feature-based modeling and feature model transformations at the top and the application software generation at the bottom. We have validated the framework using available tools and developed an experimental PHM to test some aspects of the functionality of the reference architecture in real time. The main contribution of the paper is the development of the model-driven computational framework with emphasis on the synergistic effect of security and energy issues.

  13. Public–private partnership conceptual framework and models for the ...

    African Journals Online (AJOL)

    This paper presents public–private partnership (PPP) framework models for funding and financing of water services ... capital markets to finance water infrastructure, particularly local bond markets ...... for the provision of water services infrastructure assets to be ... of water use charges and/or tariffs (pricing), regulatory impact.

  14. Generic modelling framework for economic analysis of battery systems

    DEFF Research Database (Denmark)

    You, Shi; Rasmussen, Claus Nygaard

    2011-01-01

    for battery cycle life estimation, since the cycle life plays a central role in the economic analysis of BS. To illustrate the modelling framework, a case study using a Sodium Sulfur Battery (NAS) system with 5-minute regulating service is performed. The economic performances of two dispatch scenarios, a so...

  15. A Liver-centric Multiscale Modeling Framework for Xenobiotics

    Science.gov (United States)

    We describe a multi-scale framework for modeling acetaminophen-induced liver toxicity. Acetaminophen is a widely used analgesic. Overdose of acetaminophen can result in liver injury via its biotransformation into toxic product, which further induce massive necrosis. Our study foc...

  16. Service business model framework and the service innovation scope

    NARCIS (Netherlands)

    van der Aa, W.; van der Rhee, B.; Victorino, L.

    2011-01-01

    In this paper we present a framework for service business models. We build on three streams of research. The first stream is the service management and marketing literature that focuses on the specific challenges of managing a service business. The second stream consists of research on e-business mo

  17. The BMW Model: A New Framework for Teaching Monetary Economics

    Science.gov (United States)

    Bofinger, Peter; Mayer, Eric; Wollmershauser, Timo

    2006-01-01

    Although the IS/LM-AS/AD model is still the central tool of macroeconomic teaching in most macroeconomic textbooks, it has been criticized by several economists. Colander (1995) demonstrated that the framework is logically inconsistent, Romer (2000) showed that it is unable to deal with a monetary policy that uses the interest rate as its…

  18. Model-based safety architecture framework for complex systems

    NARCIS (Netherlands)

    Schuitemaker, K.; Rajabalinejad, M.; Braakhuis, J.G.; Podofilini, Luca; Sudret, Bruno; Stojadinovic, Bozidar; Zio, Enrico; Kröger, Wolfgang

    2015-01-01

    The shift to transparency and rising need of the general public for safety, together with the increasing complexity and interdisciplinarity of modern safety-critical Systems of Systems (SoS) have resulted in a Model-Based Safety Architecture Framework (MBSAF) for capturing and sharing architectural

  19. A Graph Based Framework to Model Virus Integration Sites

    Directory of Open Access Journals (Sweden)

    Raffaele Fronza

    2016-01-01

    Here, we addressed the challenge to: 1 define the notion of CIS on graph models, 2 demonstrate that the structure of CIS enters in the category of scale-free networks and 3 show that our network approach analyzes CIS dynamically in an integrated systems biology framework using the Retroviral Transposon Tagged Cancer Gene Database (RTCGD as a testing dataset.

  20. Framework for Understanding Structural Errors (FUSE): a modular framework to diagnose differences between hydrological models

    Science.gov (United States)

    Clark, Martyn P.; Slater, Andrew G.; Rupp, David E.; Woods, Ross A.; Vrugt, Jasper A.; Gupta, Hoshin V.; Wagener, Thorsten; Hay, Lauren E.

    2008-01-01

    The problems of identifying the most appropriate model structure for a given problem and quantifying the uncertainty in model structure remain outstanding research challenges for the discipline of hydrology. Progress on these problems requires understanding of the nature of differences between models. This paper presents a methodology to diagnose differences in hydrological model structures: the Framework for Understanding Structural Errors (FUSE). FUSE was used to construct 79 unique model structures by combining components of 4 existing hydrological models. These new models were used to simulate streamflow in two of the basins used in the Model Parameter Estimation Experiment (MOPEX): the Guadalupe River (Texas) and the French Broad River (North Carolina). Results show that the new models produced simulations of streamflow that were at least as good as the simulations produced by the models that participated in the MOPEX experiment. Our initial application of the FUSE method for the Guadalupe River exposed relationships between model structure and model performance, suggesting that the choice of model structure is just as important as the choice of model parameters. However, further work is needed to evaluate model simulations using multiple criteria to diagnose the relative importance of model structural differences in various climate regimes and to assess the amount of independent information in each of the models. This work will be crucial to both identifying the most appropriate model structure for a given problem and quantifying the uncertainty in model structure. To facilitate research on these problems, the FORTRAN-90 source code for FUSE is available upon request from the lead author.

  1. A Framework for Understanding Physics Students' Computational Modeling Practices

    Science.gov (United States)

    Lunk, Brandon Robert

    With the growing push to include computational modeling in the physics classroom, we are faced with the need to better understand students' computational modeling practices. While existing research on programming comprehension explores how novices and experts generate programming algorithms, little of this discusses how domain content knowledge, and physics knowledge in particular, can influence students' programming practices. In an effort to better understand this issue, I have developed a framework for modeling these practices based on a resource stance towards student knowledge. A resource framework models knowledge as the activation of vast networks of elements called "resources." Much like neurons in the brain, resources that become active can trigger cascading events of activation throughout the broader network. This model emphasizes the connectivity between knowledge elements and provides a description of students' knowledge base. Together with resources resources, the concepts of "epistemic games" and "frames" provide a means for addressing the interaction between content knowledge and practices. Although this framework has generally been limited to describing conceptual and mathematical understanding, it also provides a means for addressing students' programming practices. In this dissertation, I will demonstrate this facet of a resource framework as well as fill in an important missing piece: a set of epistemic games that can describe students' computational modeling strategies. The development of this theoretical framework emerged from the analysis of video data of students generating computational models during the laboratory component of a Matter & Interactions: Modern Mechanics course. Student participants across two semesters were recorded as they worked in groups to fix pre-written computational models that were initially missing key lines of code. Analysis of this video data showed that the students' programming practices were highly influenced by

  2. A Systematic Modelling Framework for Phase Transfer Catalyst Systems

    DEFF Research Database (Denmark)

    Anantpinijwatna, Amata; Sales-Cruz, Mauricio; Hyung Kim, Sun

    2016-01-01

    in an aqueous phase. These reacting systems are receiving increased attention as novel organic synthesis options due to their flexible operation, higher product yields, and ability to avoid hazardous or expensive solvents. Major considerations in the design and analysis of PTC systems are physical and chemical...... equilibria, as well as kinetic mechanisms and rates. This paper presents a modelling framework for design and analysis of PTC systems that requires a minimum amount of experimental data to develop and employ the necessary thermodynamic and reaction models and embeds them into a reactor model for simulation....... The application of the framework is made to two cases in order to highlight the performance and issues of activity coefficient models for predicting design and operation and the effects when different organic solvents are employed....

  3. Indeterminate direction relation model based on fuzzy description framework

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The indetermination of direction relation is a hot topic for fuzzy GIS researchers. The existing models only study the effects of indetermination of spatial objects,but ignore the uncertainty of direction reference framework. In this paper,first a for-malized representation model of indeterminate spatial objects is designed based on quadruple (x,y,A,μ),then a fuzzy direction reference framework is constructed by revising the cone method,in which the partitions of direction tiles are smooth and continuous,and two neighboring sections are overlapped in the transitional zones with fuzzy method. Grounded on these,a fuzzy description model for indeterminate direction relation is proposed in which the uncertainty of all three parts (source object,reference object and reference frame) is taken into account simultaneously. In the end,case studies are implemented to test the rationality and validity of the model.

  4. Framework of Distributed Coupled Atmosphere-Ocean-Wave Modeling System

    Institute of Scientific and Technical Information of China (English)

    WEN Yuanqiao; HUANG Liwen; DENG Jian; ZHANG Jinfeng; WANG Sisi; WANG Lijun

    2006-01-01

    In order to research the interactions between the atmosphere and ocean as well as their important role in the intensive weather systems of coastal areas, and to improve the forecasting ability of the hazardous weather processes of coastal areas, a coupled atmosphere-ocean-wave modeling system has been developed.The agent-based environment framework for linking models allows flexible and dynamic information exchange between models. For the purpose of flexibility, portability and scalability, the framework of the whole system takes a multi-layer architecture that includes a user interface layer, computational layer and service-enabling layer. The numerical experiment presented in this paper demonstrates the performance of the distributed coupled modeling system.

  5. Switch to 1.5 grams MMF monotherapy for CNI-related toxicity in liver transplantation is safe and improves renal function, dyslipidemia, and hypertension.

    Science.gov (United States)

    Orlando, Giuseppe; Baiocchi, Leonardo; Cardillo, Andrea; Iaria, Giuseppe; De Liguori Carino, Nicola; De Liguori, Nicola; De Luca, Linda; Ielpo, Benedetto; Tariciotti, Laura; Angelico, Mario; Tisone, Giuseppe

    2007-01-01

    Although mycophenolate mofetil (MMF) monotherapy has been successfully used in liver transplant recipients suffering from calcineurin-inhibitor (CNI)-related chronic toxicity, still no consensus has been reached on its safety, efficacy and tolerability. We attempted the complete weaning off CNI in 42 individuals presenting chronic renal dysfunction and/or dyslipidemia and/or arterial hypertension and simultaneously introduced 1.5 gm/day MMF. CNI could be completely withdrawn in 41 cases. A total of 32 (75%) patients are currently on MMF. Mean follow-up from the introduction of MMF is 31.5 months and mean length of follow-up from the beginning of MMF monotherapy is 27.3 months. Renal function improved in 31/36 (89%) cases. Blood levels of cholesterol and triglycerides decreased in 13 of 17 (76%) and 15 of 17 (89%) patients, respectively. Arterial hypertension improved in 4 of 5 (80%) cases. A total of 8 patients showed a single episode of fluctuation of liver function tests during tapering off CNI. This feature was interpreted as an acute rejection (AR), based on the resolution of the clinical setting after escalation of MMF daily dose to 2 gm. A further patient developed a biopsy-proven AR insensitive to MMF adjustment, requiring reinstitution of the CNI dose. No deaths or major toxicity requiring MMF discontinuation occurred. In conclusion, low dose MMF monotherapy is safe, effective, and well tolerated.

  6. A critical analysis of racial difference with mycophenolate mofetil (MMF) dosing, clinical outcomes and adverse effects in pediatric kidney transplant patients.

    Science.gov (United States)

    Jensen, C J; Shrivastava, S; Taber, D J; Weimert, N A; Shatat, I F; Orak, J; Chavin, K D; Baliga, P K

    2011-01-01

    There is paucity in the data examining the differences in mycophenolate mofetil (MMF) dosing and outcomes among pediatric kidney transplant recipients (PKTX) between races. The aims of this study were as follows (i) to assess whether higher doses of MMF are being utilized in African American (AA) PKTX (ii) to determine whether there is a correlation between MMF dose and outcomes between races, and (iii) to assess the adverse effects of MMF between races. This study analyzed 109 PKTX who received MMF between 7/99 and 5/08. Demographics were similar between groups. Fewer AAs received kidneys from living donors (18% vs. 44%), spent more time on dialysis (1.0 vs. 0.5 yr), and had more human leukocyte antigen mismatches (4 vs. 3). MMF doses among AA patients were higher throughout the study, with statistical differences at week 4, month 3, and month 18. AA patients had significantly higher acute rejection rates and trended toward poorer graft survival; infections, adverse events from MMF and post-transplant lymphoproliferative disease tended to be lower in the AA patients. AA PKTX received higher MMF doses within the first three yr post-transplant compared to their non-AA counterparts, yet demonstrate significantly more acute rejection episodes. Importantly, MMF caused fewer adverse events in AA patients, despite these patients receiving higher doses.

  7. Theoretical Models and Operational Frameworks in Public Health Ethics

    Science.gov (United States)

    Petrini, Carlo

    2010-01-01

    The article is divided into three sections: (i) an overview of the main ethical models in public health (theoretical foundations); (ii) a summary of several published frameworks for public health ethics (practical frameworks); and (iii) a few general remarks. Rather than maintaining the superiority of one position over the others, the main aim of the article is to summarize the basic approaches proposed thus far concerning the development of public health ethics by describing and comparing the various ideas in the literature. With this in mind, an extensive list of references is provided. PMID:20195441

  8. Theoretical Models and Operational Frameworks in Public Health Ethics

    Directory of Open Access Journals (Sweden)

    Carlo Petrini

    2010-01-01

    Full Text Available The article is divided into three sections: (i an overview of the main ethical models in public health (theoretical foundations; (ii a summary of several published frameworks for public health ethics (practical frameworks; and (iii a few general remarks. Rather than maintaining the superiority of one position over the others, the main aim of the article is to summarize the basic approaches proposed thus far concerning the development of public health ethics by describing and comparing the various ideas in the literature. With this in mind, an extensive list of references is provided.

  9. A High Performance Bayesian Computing Framework for Spatiotemporal Uncertainty Modeling

    Science.gov (United States)

    Cao, G.

    2015-12-01

    All types of spatiotemporal measurements are subject to uncertainty. With spatiotemporal data becomes increasingly involved in scientific research and decision making, it is important to appropriately model the impact of uncertainty. Quantitatively modeling spatiotemporal uncertainty, however, is a challenging problem considering the complex dependence and dataheterogeneities.State-space models provide a unifying and intuitive framework for dynamic systems modeling. In this paper, we aim to extend the conventional state-space models for uncertainty modeling in space-time contexts while accounting for spatiotemporal effects and data heterogeneities. Gaussian Markov Random Field (GMRF) models, also known as conditional autoregressive models, are arguably the most commonly used methods for modeling of spatially dependent data. GMRF models basically assume that a geo-referenced variable primarily depends on its neighborhood (Markov property), and the spatial dependence structure is described via a precision matrix. Recent study has shown that GMRFs are efficient approximation to the commonly used Gaussian fields (e.g., Kriging), and compared with Gaussian fields, GMRFs enjoy a series of appealing features, such as fast computation and easily accounting for heterogeneities in spatial data (e.g, point and areal). This paper represents each spatial dataset as a GMRF and integrates them into a state-space form to statistically model the temporal dynamics. Different types of spatial measurements (e.g., categorical, count or continuous), can be accounted for by according link functions. A fast alternative to MCMC framework, so-called Integrated Nested Laplace Approximation (INLA), was adopted for model inference.Preliminary case studies will be conducted to showcase the advantages of the described framework. In the first case, we apply the proposed method for modeling the water table elevation of Ogallala aquifer over the past decades. In the second case, we analyze the

  10. Compendium of models from a gauge U(1) framework

    Science.gov (United States)

    Ma, Ernest

    2016-06-01

    A gauge U(1) framework was established in 2002 to extend the supersymmetric Standard Model. It has many possible realizations. Whereas all have the necessary and sufficient ingredients to explain the possible 750 GeV diphoton excess, observed recently by the ATLAS and CMS Collaborations at the large hadron collider (LHC), they differ in other essential aspects. A compendium of such models is discussed.

  11. Advancing Integrated Systems Modelling Framework for Life Cycle Sustainability Assessment

    Directory of Open Access Journals (Sweden)

    Anthony Halog

    2011-02-01

    Full Text Available The need for integrated methodological framework for sustainability assessment has been widely discussed and is urgent due to increasingly complex environmental system problems. These problems have impacts on ecosystems and human well-being which represent a threat to economic performance of countries and corporations. Integrated assessment crosses issues; spans spatial and temporal scales; looks forward and backward; and incorporates multi-stakeholder inputs. This study aims to develop an integrated methodology by capitalizing the complementary strengths of different methods used by industrial ecologists and biophysical economists. The computational methodology proposed here is systems perspective, integrative, and holistic approach for sustainability assessment which attempts to link basic science and technology to policy formulation. The framework adopts life cycle thinking methods—LCA, LCC, and SLCA; stakeholders analysis supported by multi-criteria decision analysis (MCDA; and dynamic system modelling. Following Pareto principle, the critical sustainability criteria, indicators and metrics (i.e., hotspots can be identified and further modelled using system dynamics or agent based modelling and improved by data envelopment analysis (DEA and sustainability network theory (SNT. The framework is being applied to development of biofuel supply chain networks. The framework can provide new ways of integrating knowledge across the divides between social and natural sciences as well as between critical and problem-solving research.

  12. Modelling Framework to Support Decision-Making in Manufacturing Enterprises

    Directory of Open Access Journals (Sweden)

    Tariq Masood

    2013-01-01

    Full Text Available Systematic model-driven decision-making is crucial to design, engineer, and transform manufacturing enterprises (MEs. Choosing and applying the best philosophies and techniques is challenging as most MEs deploy complex and unique configurations of process-resource systems and seek economies of scope and scale in respect of changing and distinctive product flows. This paper presents a novel systematic enhanced integrated modelling framework to facilitate transformation of MEs, which is centred on CIMOSA. Application of the new framework in an automotive industrial case study is also presented. The following new contributions to knowledge are made: (1 an innovative structured framework that can support various decisions in design, optimisation, and control to reconfigure MEs; (2 an enriched and generic process modelling approach with capability to represent both static and dynamic aspects of MEs; and (3 an automotive industrial case application showing benefits in terms of reduced lead time and cost with improved responsiveness of process-resource system with a special focus on PPC. It is anticipated that the new framework is not limited to only automotive industry but has a wider scope of application. Therefore, it would be interesting to extend its testing with different configurations and decision-making levels.

  13. Value of therapeutic drug monitoring of MMF therapy in pediatric transplantation.

    Science.gov (United States)

    Filler, G

    2006-09-01

    Therapeutic drug monitoring (TDM) is desirable whenever the desired drug effect cannot be predicted from a given dose, or when it is necessary to find a balance between the efficacy and toxicity of the drug. Children and adolescents particularly benefit from TDM, because dosing requirements are often not studied in the same detail as in adults. Also, drug-drug interactions are frequent. The gold standard for assessment of drug exposure is the area-under-the-curve (AUC) for a full pharmacokinetic profile. TDM for mycophenolic acid (MPA) is less well established. Monitoring of trough levels does not suffice because of enterohepatic recirculation of MPA after formation of its main metabolite, a glucoronide termed MPA-G. However, abbreviated sampling schemes specific to mycophenolate mofetil (MMF) correlate well with the AUC for MPA. Cyclosporine interacts with MPA by inhibiting the multidrug resistance-associated protein 2 (MRP2). Higher MPA concentrations result in a decreased two h concentration of cyclosporine, while higher cyclosporine exposure results in a lower MPA exposure. There are no drug interactions between tacrolimus and MPA, and lower doses of MMF are required in combination with tacrolimus. Steroids may induce the clearance of MPA, which could account in part for the increasing MPA exposure following transplantation. TDM has allowed for dosing recommendations of MMF in children, which could lead to improved efficacy and minimization of toxicities. It is important that these provisional target levels are validated in prospective studies. The above points clearly indicate that there is a role for TDM of MPA in pediatric transplant recipients.

  14. Possibilities: A framework for modeling students' deductive reasoning in physics

    Science.gov (United States)

    Gaffney, Jonathan David Housley

    Students often make errors when trying to solve qualitative or conceptual physics problems, and while many successful instructional interventions have been generated to prevent such errors, the process of deduction that students use when solving physics problems has not been thoroughly studied. In an effort to better understand that reasoning process, I have developed a new framework, which is based on the mental models framework in psychology championed by P. N. Johnson-Laird. My new framework models how students search possibility space when thinking about conceptual physics problems and suggests that errors arise from failing to flesh out all possibilities. It further suggests that instructional interventions should focus on making apparent those possibilities, as well as all physical consequences those possibilities would incur. The possibilities framework emerged from the analysis of data from a unique research project specifically invented for the purpose of understanding how students use deductive reasoning. In the selection task, participants were given a physics problem along with three written possible solutions with the goal of identifying which one of the three possible solutions was correct. Each participant was also asked to identify the errors in the incorrect solutions. For the study presented in this dissertation, participants not only performed the selection task individually on four problems, but they were also placed into groups of two or three and asked to discuss with each other the reasoning they used in making their choices and attempt to reach a consensus about which solution was correct. Finally, those groups were asked to work together to perform the selection task on three new problems. The possibilities framework appropriately models the reasoning that students use, and it makes useful predictions about potentially helpful instructional interventions. The study reported in this dissertation emphasizes the useful insight the

  15. An enhanced BSIM modeling framework for selfheating aware circuit design

    Science.gov (United States)

    Schleyer, M.; Leuschner, S.; Baumgartner, P.; Mueller, J.-E.; Klar, H.

    2014-11-01

    This work proposes a modeling framework to enhance the industry-standard BSIM4 MOSFET models with capabilities for coupled electro-thermal simulations. An automated simulation environment extracts thermal information from model data as provided by the semiconductor foundry. The standard BSIM4 model is enhanced with a Verilog-A based wrapper module, adding thermal nodes which can be connected to a thermal-equivalent RC network. The proposed framework allows a fully automated extraction process based on the netlist of the top-level design and the model library. A numerical analysis tool is used to control the extraction flow and to obtain all required parameters. The framework is used to model self-heating effects on a fully integrated class A/AB power amplifier (PA) designed in a standard 65 nm CMOS process. The PA is driven with +30 dBm output power, leading to an average temperature rise of approximately 40 °C over ambient temperature.

  16. The association between MMF and risk of progressive renal dysfunction and death in adult liver transplant recipients with HCV.

    Science.gov (United States)

    Lake, John; Patel, Dharmesh; David, Kristin; Richwine, Jason; Morris, Jonathan

    2009-01-01

    The impact of a three-drug regimen including mycophenolate mofetil (MMF) vs. a two-drug (no MMF) regimen on progressive renal dysfunction (PRD) in liver transplant recipients with hepatitis C virus (HCV) infection has not been well described. Adults with HCV who received a primary liver transplant between January 1, 2000 and December. 31, 2005 and were discharged from the hospital on a three-drug regimen [CNI+MMF+steroids (S)] (n = 4 946) were compared with those discharged on two-drug regimen (CNI+S) (n = 3 884). Time to PRD (defined by a post-transplant 25% decline in estimated GFR, based on the four-variable MDRD equation) and recipient death were evaluated using Kaplan-Meier analysis. Cox proportional hazards regression was used to estimate the risk for post-transplant PRD and death after controlling for baseline characteristics and extended steroid use. The two groups were similar in baseline characteristics. The percentage of recipients on three- vs. two-drug regimen without PRD was higher, 36.8% vs. 31.9%, (p MMF-containing regimen are at a lower risk for PRD and death compared with recipients on a regimen not including MMF.

  17. The Use of MMF Screws: Surgical Technique, Indications, Contraindications, and Common Problems in Review of the Literature.

    Science.gov (United States)

    Cornelius, Carl-Peter; Ehrenfeld, Michael

    2010-06-01

    Mandibulo-maxillary fixation (MMF) screws are inserted into the bony base of both jaws in the process of fracture realignment and immobilisation. The screw heads act as anchor points to fasten wire loops or rubber bands connecting the mandible to the maxilla. Traditional interdental chain-linked wiring or arch bar techniques provide the anchorage by attached cleats, hooks, or eyelets. In comparison to these tooth-borne appliances MMF screws facilitate and shorten the way to achieve intermaxillary fixation considerably. In addition, MMF screws help to reduce the hazards of glove perforation and wire stick injuries. On the downside, MMF screws are attributed with the risk of tooth root damage and a lack of versatility beyond the pure maintenance of occlusion such as stabilizing loose teeth or splinting fragments of the alveolar process. The surgical technique of MMF screws as well as the pros and cons of the clinical application are reviewed. The adequate screw placement to prevent serious tooth root injuries is still an issue to rethink and modify conceptual guidelines.

  18. Quantifying the effect of ecological restoration on soil erosion in China's Loess Plateau region: an application of the MMF approach.

    Science.gov (United States)

    Li, Changbin; Qi, Jiaguo; Feng, Zhaodong; Yin, Runsheng; Guo, Biyun; Zhang, Feng; Zou, Songbing

    2010-03-01

    Land degradation due to erosion is one of the most serious environmental problems in China. To reduce land degradation, the government has taken a number of conservation and restoration measures, including the Sloping Land Conversion Program (SLCP), which was launched in 1999. A logical question is whether these measures have reduced soil erosion at the regional level. The objective of this article is to answer this question by assessing soil erosion dynamics in the Zuli River basin in the Loess Plateau of China from 1999 to 2006. The MMF (Morgan, Morgan and Finney) model was used to simulate changes in runoff and soil erosion over the period of time during which ecological restoration projects were implemented. Some model variables were derived from remotely sensed images to provide improved land surface representation. With an overall accuracy rate of 0.67, our simulations show that increased ground vegetation cover, especially in forestlands and grasslands, has reduced soil erosion by 38.8% on average from 1999 to 2006. During the same time period, however, the change in rainfall pattern has caused a 13.1% +/- 4.3% increase in soil erosion, resulting in a net 25.7% +/- 8.5% reduction in soil erosion. This suggests that China's various ecological restoration efforts have been effective in reducing soil loss.

  19. A modeling framework for system restoration from cascading failures.

    Science.gov (United States)

    Liu, Chaoran; Li, Daqing; Zio, Enrico; Kang, Rui

    2014-01-01

    System restoration from cascading failures is an integral part of the overall defense against catastrophic breakdown in networked critical infrastructures. From the outbreak of cascading failures to the system complete breakdown, actions can be taken to prevent failure propagation through the entire network. While most analysis efforts have been carried out before or after cascading failures, restoration during cascading failures has been rarely studied. In this paper, we present a modeling framework to investigate the effects of in-process restoration, which depends strongly on the timing and strength of the restoration actions. Furthermore, in the model we also consider additional disturbances to the system due to restoration actions themselves. We demonstrate that the effect of restoration is also influenced by the combination of system loading level and restoration disturbance. Our modeling framework will help to provide insights on practical restoration from cascading failures and guide improvements of reliability and resilience of actual network systems.

  20. `Dhara': An Open Framework for Critical Zone Modeling

    Science.gov (United States)

    Le, P. V.; Kumar, P.

    2016-12-01

    Processes in the Critical Zone, which sustain terrestrial life, are tightly coupled across hydrological, physical, biological, chemical, pedological, geomorphological and ecological domains over both short and long timescales. Observations and quantification of the Earth's surface across these domains using emerging high resolution measurement technologies such as light detection and ranging (lidar) and hyperspectral remote sensing are enabling us to characterize fine scale landscape attributes over large spatial areas. This presents a unique opportunity to develop novel approaches to model the Critical Zone that can capture fine scale intricate dependencies across the different processes in 3D. The development of interdisciplinary tools that transcend individual disciplines and capture new levels of complexity and emergent properties is at the core of Critical Zone science. Here we introduce an open framework for high-performance computing model (`Dhara') for modeling complex processes in the Critical Zone. The framework is designed to be modular in structure with the aim to create uniform and efficient tools to facilitate and leverage process modeling. It also provides flexibility to maintain, collaborate, and co-develop additional components by the scientific community. We show the essential framework that simulates ecohydrologic dynamics, and surface - sub-surface coupling in 3D using hybrid parallel CPU-GPU. We demonstrate that the open framework in Dhara is feasible for detailed, multi-processes, and large-scale modeling of the Critical Zone, which opens up exciting possibilities. We will also present outcomes from a Modeling Summer Institute led by Intensively Managed Critical Zone Observatory (IMLCZO) with representation from several CZOs and international representatives.

  1. Mechanisms of Soil Aggregation: a biophysical modeling framework

    Science.gov (United States)

    Ghezzehei, T. A.; Or, D.

    2016-12-01

    Soil aggregation is one of the main crosscutting concepts in all sub-disciplines and applications of soil science from agriculture to climate regulation. The concept generally refers to adhesion of primary soil particles into distinct units that remain stable when subjected to disruptive forces. It is one of the most sensitive soil qualities that readily respond to disturbances such as cultivation, fire, drought, flooding, and changes in vegetation. These changes are commonly quantified and incorporated in soil models indirectly as alterations in carbon content and type, bulk density, aeration, permeability, as well as water retention characteristics. Soil aggregation that is primarily controlled by organic matter generally exhibits hierarchical organization of soil constituents into stable units that range in size from a few microns to centimeters. However, this conceptual model of soil aggregation as the key unifying mechanism remains poorly quantified and is rarely included in predictive soil models. Here we provide a biophysical framework for quantitative and predictive modeling of soil aggregation and its attendant soil characteristics. The framework treats aggregates as hotspots of biological, chemical and physical processes centered around roots and root residue. We keep track of the life cycle of an individual aggregate from it genesis in the rhizosphere, fueled by rhizodeposition and mediated by vigorous microbial activity, until its disappearance when the root-derived resources are depleted. The framework synthesizes current understanding of microbial life in porous media; water holding and soil binding capacity of biopolymers; and environmental controls on soil organic matter dynamics. The framework paves a way for integration of processes that are presently modeled as disparate or poorly coupled processes, including storage and protection of carbon, microbial activity, greenhouse gas fluxes, movement and storage of water, resistance of soils against

  2. Bayesian-based Project Monitoring: Framework Development and Model Testing

    Directory of Open Access Journals (Sweden)

    Budi Hartono

    2015-12-01

    Full Text Available During project implementation, risk becomes an integral part of project monitoring. Therefore. a tool that could dynamically include elements of risk in project progress monitoring is needed. This objective of this study is to develop a general framework that addresses such a concern. The developed framework consists of three interrelated major building blocks, namely: Risk Register (RR, Bayesian Network (BN, and Project Time Networks (PTN for dynamic project monitoring. RR is used to list and to categorize identified project risks. PTN is utilized for modeling the relationship between project activities. BN is used to reflect the interdependence among risk factors and to bridge RR and PTN. A residential development project is chosen as a working example and the result shows that the proposed framework has been successfully applied. The specific model of the development project is also successfully developed and is used to monitor the project progress. It is shown in this study that the proposed BN-based model provides superior performance in terms of forecast accuracy compared to the extant models.

  3. A VGI data integration framework based on linked data model

    Science.gov (United States)

    Wan, Lin; Ren, Rongrong

    2015-12-01

    This paper aims at the geographic data integration and sharing method for multiple online VGI data sets. We propose a semantic-enabled framework for online VGI sources cooperative application environment to solve a target class of geospatial problems. Based on linked data technologies - which is one of core components of semantic web, we can construct the relationship link among geographic features distributed in diverse VGI platform by using linked data modeling methods, then deploy these semantic-enabled entities on the web, and eventually form an interconnected geographic data network to support geospatial information cooperative application across multiple VGI data sources. The mapping and transformation from VGI sources to RDF linked data model is presented to guarantee the unique data represent model among different online social geographic data sources. We propose a mixed strategy which combined spatial distance similarity and feature name attribute similarity as the measure standard to compare and match different geographic features in various VGI data sets. And our work focuses on how to apply Markov logic networks to achieve interlinks of the same linked data in different VGI-based linked data sets. In our method, the automatic generating method of co-reference object identification model according to geographic linked data is discussed in more detail. It finally built a huge geographic linked data network across loosely-coupled VGI web sites. The results of the experiment built on our framework and the evaluation of our method shows the framework is reasonable and practicable.

  4. Long-term follow-up of cognitive dysfunction in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF).

    Science.gov (United States)

    Passeri, Elodie; Villa, Chiara; Couette, Maryline; Itti, Emmanuel; Brugieres, Pierre; Cesaro, Pierre; Gherardi, Romain K; Bachoud-Levi, Anne-Catherine; Authier, François-Jérôme

    2011-11-01

    Macrophagic myofasciitis (MMF) is characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and cognitive dysfunction. Representative features of MMF-associated cognitive dysfunction (MACD) include (i) dysexecutive syndrome; (i) visual memory; (iii) left ear extinction at dichotic listening test. In present study we retrospectively evaluated the progression of MACD in 30 MMF patients. Most patients fulfilled criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits seemed unusually severe. MACD remained stable over time, although dysexecutive syndrome tended to worsen. Long-term follow-up of a subset of patients with 3 or 4 consecutive neuropsychological evaluations confirmed the stability of MACD with time, despite marked fluctuations.

  5. A Building Model Framework for a Genetic Algorithm Multi-objective Model Predictive Control

    DEFF Research Database (Denmark)

    Arendt, Krzysztof; Ionesi, Ana; Jradi, Muhyiddine

    2016-01-01

    Mock-Up Interface, which is used to link the models with the MPC system. The framework was used to develop and run initial thermal and CO2 models. Their performance and the implementation procedure are discussed in the present paper. The framework is going to be implemented in the MPC system planned...

  6. A framework to model real-time databases

    CERN Document Server

    Idoudi, Nizar; Duvallet, Claude; Sadeg, Bruno; Bouaziz, Rafik; Gargouri, Faiez

    2010-01-01

    Real-time databases deal with time-constrained data and time-constrained transactions. The design of this kind of databases requires the introduction of new concepts to support both data structures and the dynamic behaviour of the database. In this paper, we give an overview about different aspects of real-time databases and we clarify requirements of their modelling. Then, we present a framework for real-time database design and describe its fundamental operations. A case study demonstrates the validity of the structural model and illustrates SQL queries and Java code generated from the classes of the model

  7. An Integrated Modeling Framework for Probable Maximum Precipitation and Flood

    Science.gov (United States)

    Gangrade, S.; Rastogi, D.; Kao, S. C.; Ashfaq, M.; Naz, B. S.; Kabela, E.; Anantharaj, V. G.; Singh, N.; Preston, B. L.; Mei, R.

    2015-12-01

    With the increasing frequency and magnitude of extreme precipitation and flood events projected in the future climate, there is a strong need to enhance our modeling capabilities to assess the potential risks on critical energy-water infrastructures such as major dams and nuclear power plants. In this study, an integrated modeling framework is developed through high performance computing to investigate the climate change effects on probable maximum precipitation (PMP) and probable maximum flood (PMF). Multiple historical storms from 1981-2012 over the Alabama-Coosa-Tallapoosa River Basin near the Atlanta metropolitan area are simulated by the Weather Research and Forecasting (WRF) model using the Climate Forecast System Reanalysis (CFSR) forcings. After further WRF model tuning, these storms are used to simulate PMP through moisture maximization at initial and lateral boundaries. A high resolution hydrological model, Distributed Hydrology-Soil-Vegetation Model, implemented at 90m resolution and calibrated by the U.S. Geological Survey streamflow observations, is then used to simulate the corresponding PMF. In addition to the control simulation that is driven by CFSR, multiple storms from the Community Climate System Model version 4 under the Representative Concentrations Pathway 8.5 emission scenario are used to simulate PMP and PMF in the projected future climate conditions. The multiple PMF scenarios developed through this integrated modeling framework may be utilized to evaluate the vulnerability of existing energy-water infrastructures with various aspects associated PMP and PMF.

  8. Automatic Model Generation Framework for Computational Simulation of Cochlear Implantation

    DEFF Research Database (Denmark)

    Mangado Lopez, Nerea; Ceresa, Mario; Duchateau, Nicolas

    2016-01-01

    Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging. To addr......Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging....... To address such a challenge, we propose an automatic framework for the generation of patient-specific meshes for finite element modeling of the implanted cochlea. First, a statistical shape model is constructed from high-resolution anatomical μCT images. Then, by fitting the statistical model to a patient......'s CT image, an accurate model of the patient-specific cochlea anatomy is obtained. An algorithm based on the parallel transport frame is employed to perform the virtual insertion of the cochlear implant. Our automatic framework also incorporates the surrounding bone and nerve fibers and assigns...

  9. A Structural Model Decomposition Framework for Systems Health Management

    Science.gov (United States)

    Roychoudhury, Indranil; Daigle, Matthew J.; Bregon, Anibal; Pulido, Belamino

    2013-01-01

    Systems health management (SHM) is an important set of technologies aimed at increasing system safety and reliability by detecting, isolating, and identifying faults; and predicting when the system reaches end of life (EOL), so that appropriate fault mitigation and recovery actions can be taken. Model-based SHM approaches typically make use of global, monolithic system models for online analysis, which results in a loss of scalability and efficiency for large-scale systems. Improvement in scalability and efficiency can be achieved by decomposing the system model into smaller local submodels and operating on these submodels instead. In this paper, the global system model is analyzed offline and structurally decomposed into local submodels. We define a common model decomposition framework for extracting submodels from the global model. This framework is then used to develop algorithms for solving model decomposition problems for the design of three separate SHM technologies, namely, estimation (which is useful for fault detection and identification), fault isolation, and EOL prediction. We solve these model decomposition problems using a three-tank system as a case study.

  10. A Simulink simulation framework of a MagLev model

    Energy Technology Data Exchange (ETDEWEB)

    Boudall, H.; Williams, R.D.; Giras, T.C. [University of Virginia, Charlottesville (United States). School of Enegineering and Applied Science

    2003-09-01

    This paper presents a three-degree-of-freedom model of a section of the magnetically levitated train Maglev. The Maglev system dealt with in this article utilizes electromagnetic levitation. Each MagLev vehicle section is viewed as two separate parts, namely a body and a chassis, coupled by a set of springs and dampers. The MagLev model includes the propulsion, the guidance and the levitation systems. The equations of motion are developed. A Simulink simulation framework is implemented in order to study the interaction between the different systems and the dynamics of a MagLev vehicle. The simulation framework will eventually serve as a tool to assist the design and development of the Maglev system in the United States of America. (author)

  11. Modelling Framework and Assistive Device for Peripheral Intravenous Injections

    Science.gov (United States)

    Kam, Kin F.; Robinson, Martin P.; Gilbert, Mathew A.; Pelah, Adar

    2016-02-01

    Intravenous access for blood sampling or drug administration that requires peripheral venepuncture is perhaps the most common invasive procedure practiced in hospitals, clinics and general practice surgeries.We describe an idealised mathematical framework for modelling the dynamics of the peripheral venepuncture process. Basic assumptions of the model are confirmed through motion analysis of needle trajectories during venepuncture, taken from video recordings of a skilled practitioner injecting into a practice kit. The framework is also applied to the design and construction of a proposed device for accurate needle guidance during venepuncture administration, assessed as consistent and repeatable in application and does not lead to over puncture. The study provides insights into the ubiquitous peripheral venepuncture process and may contribute to applications in training and in the design of new devices, including for use in robotic automation.

  12. Integrating knowledge seeking into knowledge management models and frameworks

    Directory of Open Access Journals (Sweden)

    Francois Lottering

    2012-02-01

    Full Text Available Background: A striking feature of the knowledge management (KM literature is that the standard list of KM processes either subsumes or overlooks the process of knowledge seeking. Knowledge seeking is manifestly under-theorised, making the need to address this gap in KM theory and practice clear and urgent.Objectives: This article investigates the theoretical status of the knowledge-seeking process in extant KM models and frameworks. It also statistically describes knowledge seeking and knowledge sharing practices in a sample of South African companies. Using this data, it proposes a KM model based on knowledge seeking.Method: Knowledge seeking is traced in a number of KM models and frameworks with a specific focus on Han Lai and Margaret Graham’s adapted KM cycle model, which separates knowledge seeking from knowledge sharing. This empirical investigation used a questionnaire to examine knowledge seeking and knowledge sharing practices in a sample of South African companies.Results: This article critiqued and elaborated on the adapted KM cycle model of Lai and Graham. It identified some of the key features of knowledge seeking practices in the workplace. It showed that knowledge seeking and sharing are human-centric actions and that seeking knowledge uses trust and loyalty as its basis. It also showed that one cannot separate knowledge seeking from knowledge sharing.Conclusion: The knowledge seeking-based KM model elaborates on Lai and Graham’s model. It provides insight into how and where people seek and share knowledge in the workplace. The article concludes that it is necessary to cement the place of knowledge seeking in KM models as well as frameworks and suggests that organisations should apply its findings to improving their knowledge management strategies. 

  13. Certified reduced basis model validation: A frequentistic uncertainty framework

    OpenAIRE

    Patera, A. T.; Huynh, Dinh Bao Phuong; Knezevic, David; Patera, Anthony T.

    2011-01-01

    We introduce a frequentistic validation framework for assessment — acceptance or rejection — of the consistency of a proposed parametrized partial differential equation model with respect to (noisy) experimental data from a physical system. Our method builds upon the Hotelling T[superscript 2] statistical hypothesis test for bias first introduced by Balci and Sargent in 1984 and subsequently extended by McFarland and Mahadevan (2008). Our approach introduces two new elements: a spectral repre...

  14. Common and Innovative Visuals: A sparsity modeling framework for video.

    Science.gov (United States)

    Abdolhosseini Moghadam, Abdolreza; Kumar, Mrityunjay; Radha, Hayder

    2014-05-02

    Efficient video representation models are critical for many video analysis and processing tasks. In this paper, we present a framework based on the concept of finding the sparsest solution to model video frames. To model the spatio-temporal information, frames from one scene are decomposed into two components: (i) a common frame, which describes the visual information common to all the frames in the scene/segment, and (ii) a set of innovative frames, which depicts the dynamic behaviour of the scene. The proposed approach exploits and builds on recent results in the field of compressed sensing to jointly estimate the common frame and the innovative frames for each video segment. We refer to the proposed modeling framework by CIV (Common and Innovative Visuals). We show how the proposed model can be utilized to find scene change boundaries and extend CIV to videos from multiple scenes. Furthermore, the proposed model is robust to noise and can be used for various video processing applications without relying on motion estimation and detection or image segmentation. Results for object tracking, video editing (object removal, inpainting) and scene change detection are presented to demonstrate the efficiency and the performance of the proposed model.

  15. Dynamic modelling of household automobile transactions within a microsimulation framework

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadian, A.

    2002-07-01

    This thesis presents a newly developed dynamic model of household automobile transactions within an integrated land-use transportation and environment (ILUTE) modeling system framework. It is a market-based decision-making tool for use by individuals who have to choose between adding new vehicles to a fleet, disposing of vehicles, trading one of the vehicles of a fleet, or do-nothing. Different approaches were used within the model, including an artificial neural network, hedonic price, regression, and vehicle class and vintage choices. The model can also predict the complex activity of individuals' behaviour to become active in the market. An estimation approach was used to incorporate the vehicle type choice model into the main dynamic transaction choice model.

  16. A framework for the calibration of social simulation models

    CERN Document Server

    Ciampaglia, Giovanni Luca

    2013-01-01

    Simulation with agent-based models is increasingly used in the study of complex socio-technical systems and in social simulation in general. This paradigm offers a number of attractive features, namely the possibility of modeling emergent phenomena within large populations. As a consequence, often the quantity in need of calibration may be a distribution over the population whose relation with the parameters of the model is analytically intractable. Nevertheless, we can simulate. In this paper we present a simulation-based framework for the calibration of agent-based models with distributional output based on indirect inference. We illustrate our method step by step on a model of norm emergence in an online community of peer production, using data from three large Wikipedia communities. Model fit and diagnostics are discussed.

  17. In-building Unlicensed WiFi Band OFDM Signal Distribution over MMF&BIF Using VCSEL

    DEFF Research Database (Denmark)

    Deng, Lei; Jensen, Jesper Bevensee; Yu, Xianbin

    2011-01-01

    For in-building applications, an OFDM-VCSEL RoF system operating in unlicensed WiFi band is experimentally tested using MMF and bend insensitive fiber (BIF). A spectral efficiency of 4.32 bit/s/Hz with 0.9 Gbps data rate is achieved.......For in-building applications, an OFDM-VCSEL RoF system operating in unlicensed WiFi band is experimentally tested using MMF and bend insensitive fiber (BIF). A spectral efficiency of 4.32 bit/s/Hz with 0.9 Gbps data rate is achieved....

  18. Population balance models: a useful complementary modelling framework for future WWTP modelling.

    Science.gov (United States)

    Nopens, Ingmar; Torfs, Elena; Ducoste, Joel; Vanrolleghem, Peter A; Gernaey, Krist V

    2015-01-01

    Population balance models (PBMs) represent a powerful modelling framework for the description of the dynamics of properties that are characterised by distributions. This distribution of properties under transient conditions has been demonstrated in many chemical engineering applications. Modelling efforts of several current and future unit processes in wastewater treatment plants could potentially benefit from this framework, especially when distributed dynamics have a significant impact on the overall unit process performance. In these cases, current models that rely on average properties cannot sufficiently capture the true behaviour and even lead to completely wrong conclusions. Examples of distributed properties are bubble size, floc size, crystal size or granule size. In these cases, PBMs can be used to develop new knowledge that can be embedded in our current models to improve their predictive capability. Hence, PBMs should be regarded as a complementary modelling framework to biokinetic models. This paper provides an overview of current applications, future potential and limitations of PBMs in the field of wastewater treatment modelling, thereby looking over the fence to other scientific disciplines.

  19. Population Balance Models: A useful complementary modelling framework for future WWTP modelling

    DEFF Research Database (Denmark)

    Nopens, Ingmar; Torfs, Elena; Ducoste, Joel

    2014-01-01

    processes in WWTPs could potentially benefit from this framework, especially when distributed dynamics have a significant impact on the overall unit process performance. In these cases, current models that rely on average properties cannot sufficiently captured the true behaviour. Examples are bubble size...

  20. An Integrated Snow Radiance and Snow Physics Modeling Framework for Cold Land Surface Modeling

    Science.gov (United States)

    Kim, Edward J.; Tedesco, Marco

    2006-01-01

    Recent developments in forward radiative transfer modeling and physical land surface modeling are converging to allow the assembly of an integrated snow/cold lands modeling framework for land surface modeling and data assimilation applications. The key elements of this framework include: a forward radiative transfer model (FRTM) for snow, a snowpack physical model, a land surface water/energy cycle model, and a data assimilation scheme. Together these form a flexible framework for self-consistent remote sensing and water/energy cycle studies. In this paper we will describe the elements and the integration plan. Each element of this framework is modular so the choice of element can be tailored to match the emphasis of a particular study. For example, within our framework, four choices of a FRTM are available to simulate the brightness temperature of snow: Two models are available to model the physical evolution of the snowpack and underlying soil, and two models are available to handle the water/energy balance at the land surface. Since the framework is modular, other models-physical or statistical--can be accommodated, too. All modules will operate within the framework of the Land Information System (LIS), a land surface modeling framework with data assimilation capabilities running on a parallel-node computing cluster at the NASA Goddard Space Flight Center. The advantages of such an integrated modular framework built on the LIS will be described through examples-e.g., studies to analyze snow field experiment observations, and simulations of future satellite missions for snow and cold land processes.

  1. C-HiLasso: A Collaborative Hierarchical Sparse Modeling Framework

    CERN Document Server

    Sprechmann, Pablo; Sapiro, Guillermo; Eldar, Yonina

    2010-01-01

    Sparse modeling is a powerful framework for data analysis and processing. Traditionally, encoding in this framework is performed by solving an L1-regularized linear regression problem, commonly referred to as Lasso or Basis Pursuit. In this work we combine the sparsity-inducing property of the Lasso model at the individual feature level, with the block-sparsity property of the Group Lasso model, where sparse groups of features are jointly encoded, obtaining a sparsity pattern hierarchically structured. This results in the Hierarchical Lasso (HiLasso), which shows important practical modeling advantages. We then extend this approach to the collaborative case, where a set of simultaneously coded signals share the same sparsity pattern at the higher (group) level, but not necessarily at the lower (inside the group) level, obtaining the collaborative HiLasso model (C-HiLasso). Such signals then share the same active groups, or classes, but not necessarily the same active set. This model is very well suited for ap...

  2. Applications and Improvement of a Coupled, Global and Cloud-Resolving Modeling System

    Science.gov (United States)

    Tao, W.-K.; Chern, J.; Atlas, R.

    2005-01-01

    Recently Grabowski (2001) and Khairoutdinov and Randall (2001) have proposed the use of 2D CFWs as a "super parameterization" [or multi-scale modeling framework (MMF)] to represent cloud processes within atmospheric general circulation models (GCMs). In the MMF, a fine-resolution 2D CRM takes the place of the single-column parameterization used in conventional GCMs. A prototype Goddard MMF based on the 2D Goddard Cumulus Ensemble (GCE) model and the Goddard finite volume general circulation model (fvGCM) is now being developed. The prototype includes the fvGCM run at 2.50 x 20 horizontal resolution with 32 vertical layers from the surface to 1 mb and the 2D (x-z) GCE using 64 horizontal and 32 vertical grid points with 4 km horizontal resolution and a cyclic lateral boundary. The time step for the 2D GCE would be 15 seconds, and the fvGCM-GCE coupling frequency would be 30 minutes (i.e. the fvGCM physical time step). We have successfully developed an fvGCM-GCE coupler for this prototype. Because the vertical coordinate of the fvGCM (a terrain-following floating Lagrangian coordinate) is different from that of the GCE (a z coordinate), vertical interpolations between the two coordinates are needed in the coupler. In interpolating fields from the GCE to fvGCM, we use an existing fvGCM finite- volume piecewise parabolic mapping (PPM) algorithm, which conserves the mass, momentum, and total energy. A new finite-volume PPM algorithm, which conserves the mass, momentum and moist static energy in the z coordinate, is being developed for interpolating fields from the fvGCM to the GCE. In the meeting, we will discuss the major differences between the two MMFs (i.e., the CSU MMF and the Goddard MMF). We will also present performance and critical issues related to the MMFs. In addition, we will present multi-dimensional cloud datasets (i.e., a cloud data library) generated by the Goddard MMF that will be provided to the global modeling community to help improve the

  3. Lack of correlation between MMF dose and MPA level in pediatric and young adult cardiac transplant patients: does the MPA level matter?

    Science.gov (United States)

    Gajarski, Robert J; Crowley, Dennis C; Zamberlan, Mary C; Lake, Kathleen D

    2004-09-01

    To determine the correlation between mycophenolate mofetil (MMF) dose and mycophenolic acid (MPA) level as well as its impact on rejection among young cardiac transplant recipients (OHT), trough concentrations of MPA and its metabolite, mycophenolic acid glucuronide (MPAG), were measured following MMF doses of 1200 mg/m2/d (max 3000 mg/d). Corresponding endomyocardial biopsy (EMB) grades and calcineurin inhibitor levels were recorded with simultaneous MPA/MPAG levels. Correlation coefficients were derived between MMF dose and MPA/MPAG levels. Contingency analysis evaluated the relation between MPA level and EMB score. Twenty-six patients (median age 15.4 years) had 120 MPA/MPAG levels measured. Average MMF dose was 1208.8 mg/m2/d with median MPA and MPAG concentrations: 2.1 (therapeutic: 1.0-3.5 microg/mL) and 48 microg/mL (reference range: 35-100 microg/mL), respectively. Only 50% of patients consistently achieved therapeutic levels with standard dosing. No correlation was found between MMF dose and MPA/MPAG levels. In the presence of therapeutic calcineurin inhibition, EMB grade > or = 2 occurred more with MPA concentrations MMF dose does not correlate with MPA/MPAG levels, and standard MMF dosing fails to consistently achieve 'therapeutic' MPA concentrations. An MPA trough level or = 2. Concentration rather than dose-driven management is a more prudent strategy when using MMF.

  4. Designing for Learning and Play - The Smiley Model as Framework

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke

    2016-01-01

    This paper presents a framework for designing engaging learning experiences in games – the Smiley Model. In this Design-Based Research project, student-game-designers were learning inside a gamified learning design - while designing and implementing learning goals from curriculum into the small...... digital games. The Smiley Model inspired and provided a scaffold or a heuristic for the overall gamified learning design –- as well as for the students’ learning game design processes when creating small games turning the learning situation into an engaging experience. The audience for the experiments...

  5. A constitutive model for magnetostriction based on thermodynamic framework

    Science.gov (United States)

    Ho, Kwangsoo

    2016-08-01

    This work presents a general framework for the continuum-based formulation of dissipative materials with magneto-mechanical coupling in the viewpoint of irreversible thermodynamics. The thermodynamically consistent model developed for the magnetic hysteresis is extended to include the magnetostrictive effect. The dissipative and hysteretic response of magnetostrictive materials is captured through the introduction of internal state variables. The evolution rate of magnetostrictive strain as well as magnetization is derived from thermodynamic and dissipative potentials in accordance with the general principles of thermodynamics. It is then demonstrated that the constitutive model is competent to describe the magneto-mechanical behavior by comparing simulation results with the experimental data reported in the literature.

  6. Next generation framework for aquatic modeling of the Earth System

    Directory of Open Access Journals (Sweden)

    C. J. Vörösmarty

    2009-03-01

    Full Text Available Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the complexity of the surrounding IT infrastructure is growing as well. Earth System models must manage a vast amount of data in heterogeneous computing environments. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc., they are still considerably complex and often have steep learning curves.

    The Next generation Framework for Aquatic Modeling of the Earth System (NextFrAMES, a revised version of FrAMES have numerous similarities to those developed by other teams, but represents a novel model development paradigm. NextFrAMES is built around a modeling XML that lets modelers to express the overall model structure and provides an API for dynamically linked plugins to represent the processes. The model XML is executed by the NextFrAMES run-time engine that parses the model definition, loads the module plugins, performs the model I/O and executes the model calculations. NextFrAMES has a minimalistic view representing spatial domains and treats every domain (regardless of its layout such as grid, network tree, individual points, polygons, etc. as vector of objects. NextFrAMES performs computations on multiple domains and interactions between different spatial domains are carried out through couplers. NextFrAMES allows processes to operate at different frequencies by providing rudimentary aggregation and disaggregation facilities.

    NextFrAMES was

  7. Model Selection Framework for Graph-based data

    CERN Document Server

    Caceres, Rajmonda S; Schmidt, Matthew C; Miller, Benjamin A; Campbell, William M

    2016-01-01

    Graphs are powerful abstractions for capturing complex relationships in diverse application settings. An active area of research focuses on theoretical models that define the generative mechanism of a graph. Yet given the complexity and inherent noise in real datasets, it is still very challenging to identify the best model for a given observed graph. We discuss a framework for graph model selection that leverages a long list of graph topological properties and a random forest classifier to learn and classify different graph instances. We fully characterize the discriminative power of our approach as we sweep through the parameter space of two generative models, the Erdos-Renyi and the stochastic block model. We show that our approach gets very close to known theoretical bounds and we provide insight on which topological features play a critical discriminating role.

  8. A framework for similarity recognition of CAD models

    Directory of Open Access Journals (Sweden)

    Leila Zehtaban

    2016-07-01

    Full Text Available A designer is mainly supported by two essential factors in design decisions. These two factors are intelligence and experience aiding the designer by predicting the interconnection between the required design parameters. Through classification of product data and similarity recognition between new and existing designs, it is partially possible to replace the required experience for an inexperienced designer. Given this context, the current paper addresses a framework for recognition and flexible retrieval of similar models in product design. The idea is to establish an infrastructure for transferring design as well as the required PLM (Product Lifecycle Management know-how to the design phase of product development in order to reduce the design time. Furthermore, such a method can be applied as a brainstorming method for a new and creative product development as well. The proposed framework has been tested and benchmarked while showing promising results.

  9. The ontology model of FrontCRM framework

    Science.gov (United States)

    Budiardjo, Eko K.; Perdana, Wira; Franshisca, Felicia

    2013-03-01

    Adoption and implementation of Customer Relationship Management (CRM) is not merely a technological installation, but the emphasis is more on the application of customer-centric philosophy and culture as a whole. CRM must begin at the level of business strategy, the only level that thorough organizational changes are possible to be done. Changes agenda can be directed to each departmental plans, and supported by information technology. Work processes related to CRM concept include marketing, sales, and services. FrontCRM is developed as framework to guide in identifying business processes related to CRM in which based on the concept of strategic planning approach. This leads to processes and practices identification in every process area related to marketing, sales, and services. The Ontology model presented on this paper by means serves as tools to avoid framework misunderstanding, to define practices systematically within process area and to find CRM software features related to those practices.

  10. Modeling phenotypic plasticity in growth trajectories: a statistical framework.

    Science.gov (United States)

    Wang, Zhong; Pang, Xiaoming; Wu, Weimiao; Wang, Jianxin; Wang, Zuoheng; Wu, Rongling

    2014-01-01

    Phenotypic plasticity, that is multiple phenotypes produced by a single genotype in response to environmental change, has been thought to play an important role in evolution and speciation. Historically, knowledge about phenotypic plasticity has resulted from the analysis of static traits measured at a single time point. New insight into the adaptive nature of plasticity can be gained by an understanding of how organisms alter their developmental processes in a range of environments. Recent advances in statistical modeling of functional data and developmental genetics allow us to construct a dynamic framework of plastic response in developmental form and pattern. Under this framework, development, genetics, and evolution can be synthesized through statistical bridges to better address how evolution results from phenotypic variation in the process of development via genetic alterations.

  11. Velo: A Knowledge Management Framework for Modeling and Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Gorton, Ian; Sivaramakrishnan, Chandrika; Black, Gary D.; White, Signe K.; Purohit, Sumit; Lansing, Carina S.; Madison, Michael C.; Schuchardt, Karen L.; Liu, Yan

    2012-03-01

    Modern scientific enterprises are inherently knowledge-intensive. Scientific studies in domains such as geosciences, climate, and biology require the acquisition and manipulation of large amounts of experimental and field data to create inputs for large-scale computational simulations. The results of these simulations are then analyzed, leading to refinements of inputs and models and additional simulations. The results of this process must be managed and archived to provide justifications for regulatory decisions and publications that are based on the models. In this paper we introduce our Velo framework that is designed as a reusable, domain independent knowledge management infrastructure for modeling and simulation. Velo leverages, integrates and extends open source collaborative and content management technologies to create a scalable and flexible core platform that can be tailored to specific scientific domains. We describe the architecture of Velo for managing and associating the various types of data that are used and created in modeling and simulation projects, as well as the framework for integrating domain-specific tools. To demonstrate realizations of Velo, we describe examples from two deployed sites for carbon sequestration and climate modeling. These provide concrete example of the inherent extensibility and utility of our approach.

  12. Optimization Framework for Stochastic Modeling of Annual Streamflows

    Science.gov (United States)

    Srivastav, R. K.; Srinivasan, K.; Sudheer, K.

    2008-12-01

    Synthetic streamflow data generation involves the synthesis of likely streamflow patterns that are statistically indistinguishable from the observed streamflow data. The various kinds of stochastic models adopted for streamflow generation in hydrology are: i) parametric models which hypothesize the form of the dependence structure and the distributional form a priori (examples are AR, ARMA); ii) Nonparametric models (examples are bootstrap/kernel based methods), which characterize the laws of chance, describing the stream flow process, without recourse to prior assumptions as to the form or structure of these laws; iii) Hybrid models which blend both parametric and non-parametric models advantageously to model the streamflows effectively. Despite many of these developments that have taken place in the field of stochastic modeling of streamflows over the last four decades, accurate prediction of the storage and the critical drought (water use) characteristics has been posing a persistent challenge to the stochastic modeler. This may be because, usually, the stochastic streamflow model parameters are estimated by minimizing a statistically based objective function (such as maximum likelihood (MLE) or least squares estimation) and subsequently the efficacy of the models is being validated based on the accuracy of prediction of the estimates of the water- use characteristics. In this study a framework is proposed to find the optimal hybrid model (blend of ARMA(1,1) and moving block bootstrap (MBB)) based on the explicit objective function of minimizing the relative bias in estimating the storage capacity of the reservoir. The optimal parameter set of the hybrid model is obtained based on the search over a multi-dimensional parameter space involving simultaneous exploration of the parametric (ARMA[1,1]) as well as the non-parametric (MBB) components. This is achieved using the efficient evolutionary search based optimization tool namely, non-dominated sorting genetic

  13. A Structural Model Decomposition Framework for Hybrid Systems Diagnosis

    Science.gov (United States)

    Daigle, Matthew; Bregon, Anibal; Roychoudhury, Indranil

    2015-01-01

    Nowadays, a large number of practical systems in aerospace and industrial environments are best represented as hybrid systems that consist of discrete modes of behavior, each defined by a set of continuous dynamics. These hybrid dynamics make the on-line fault diagnosis task very challenging. In this work, we present a new modeling and diagnosis framework for hybrid systems. Models are composed from sets of user-defined components using a compositional modeling approach. Submodels for residual generation are then generated for a given mode, and reconfigured efficiently when the mode changes. Efficient reconfiguration is established by exploiting causality information within the hybrid system models. The submodels can then be used for fault diagnosis based on residual generation and analysis. We demonstrate the efficient causality reassignment, submodel reconfiguration, and residual generation for fault diagnosis using an electrical circuit case study.

  14. Generalized framework for context-specific metabolic model extraction methods

    Directory of Open Access Journals (Sweden)

    Semidán eRobaina Estévez

    2014-09-01

    Full Text Available Genome-scale metabolic models are increasingly applied to investigate the physiology not only of simple prokaryotes, but also eukaryotes, such as plants, characterized with compartmentalized cells of multiple types. While genome-scale models aim at including the entirety of known metabolic reactions, mounting evidence has indicated that only a subset of these reactions is active in a given context, including: developmental stage, cell type, or environment. As a result, several methods have been proposed to reconstruct context-specific models from existing genome-scale models by integrating various types of high-throughput data. Here we present a mathematical framework that puts all existing methods under one umbrella and provides the means to better understand their functioning, highlight similarities and differences, and to help users in selecting a most suitable method for an application.

  15. A computational framework for modeling targets as complex adaptive systems

    Science.gov (United States)

    Santos, Eugene; Santos, Eunice E.; Korah, John; Murugappan, Vairavan; Subramanian, Suresh

    2017-05-01

    Modeling large military targets is a challenge as they can be complex systems encompassing myriad combinations of human, technological, and social elements that interact, leading to complex behaviors. Moreover, such targets have multiple components and structures, extending across multiple spatial and temporal scales, and are in a state of change, either in response to events in the environment or changes within the system. Complex adaptive system (CAS) theory can help in capturing the dynamism, interactions, and more importantly various emergent behaviors, displayed by the targets. However, a key stumbling block is incorporating information from various intelligence, surveillance and reconnaissance (ISR) sources, while dealing with the inherent uncertainty, incompleteness and time criticality of real world information. To overcome these challenges, we present a probabilistic reasoning network based framework called complex adaptive Bayesian Knowledge Base (caBKB). caBKB is a rigorous, overarching and axiomatic framework that models two key processes, namely information aggregation and information composition. While information aggregation deals with the union, merger and concatenation of information and takes into account issues such as source reliability and information inconsistencies, information composition focuses on combining information components where such components may have well defined operations. Since caBKBs can explicitly model the relationships between information pieces at various scales, it provides unique capabilities such as the ability to de-aggregate and de-compose information for detailed analysis. Using a scenario from the Network Centric Operations (NCO) domain, we will describe how our framework can be used for modeling targets with a focus on methodologies for quantifying NCO performance metrics.

  16. Vulnerability Assessment Models to Drought: Toward a Conceptual Framework

    Directory of Open Access Journals (Sweden)

    Kiumars Zarafshani

    2016-06-01

    Full Text Available Drought is regarded as a slow-onset natural disaster that causes inevitable damage to water resources and to farm life. Currently, crisis management is the basis of drought mitigation plans, however, thus far studies indicate that effective drought management strategies are based on risk management. As a primary tool in mitigating the impact of drought, vulnerability assessment can be used as a benchmark in drought mitigation plans and to enhance farmers’ ability to cope with drought. Moreover, literature pertaining to drought has focused extensively on its impact, only awarding limited attention to vulnerability assessment as a tool. Therefore, the main purpose of this paper is to develop a conceptual framework for designing a vulnerability model in order to assess farmers’ level of vulnerability before, during and after the onset of drought. Use of this developed drought vulnerability model would aid disaster relief workers by enhancing the adaptive capacity of farmers when facing the impacts of drought. The paper starts with the definition of vulnerability and outlines different frameworks on vulnerability developed thus far. It then identifies various approaches of vulnerability assessment and finally offers the most appropriate model. The paper concludes that the introduced model can guide drought mitigation programs in countries that are impacted the most by drought.

  17. Computer-aided modeling framework – a generic modeling template for catalytic membrane fixed bed reactors

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    2013-01-01

    This work focuses on development of computer-aided modeling framework. The framework is a knowledge-based system that is built on a generic modeling language and structured based on workflows for different general modeling tasks. The overall objective of this work is to support the model developers...... and users to generate and test models systematically, efficiently and reliably. In this way, development of products and processes can be faster, cheaper and very efficient. In this contribution, as part of the framework a generic modeling template for the systematic derivation of problem specific catalytic...... membrane fixed bed models is developed. The application of the modeling template is highlighted with a case study related to the modeling of a catalytic membrane reactor coupling dehydrogenation of ethylbenzene with hydrogenation of nitrobenzene....

  18. Tarmo: A Framework for Parallelized Bounded Model Checking

    CERN Document Server

    Wieringa, Siert; Heljanko, Keijo; 10.4204/EPTCS.14.5

    2009-01-01

    This paper investigates approaches to parallelizing Bounded Model Checking (BMC) for shared memory environments as well as for clusters of workstations. We present a generic framework for parallelized BMC named Tarmo. Our framework can be used with any incremental SAT encoding for BMC but for the results in this paper we use only the current state-of-the-art encoding for full PLTL. Using this encoding allows us to check both safety and liveness properties, contrary to an earlier work on distributing BMC that is limited to safety properties only. Despite our focus on BMC after it has been translated to SAT, existing distributed SAT solvers are not well suited for our application. This is because solving a BMC problem is not solving a set of independent SAT instances but rather involves solving multiple related SAT instances, encoded incrementally, where the satisfiability of each instance corresponds to the existence of a counterexample of a specific length. Our framework includes a generic architecture for a ...

  19. The use of low-dose cyclophosphamide followed by AZA/MMF treatment in childhood lupus nephritis.

    Science.gov (United States)

    Baskin, Esra; Ozen, Seza; Cakar, Nilgun; Bayrakci, Umut S; Demirkaya, Erkan; Bakkaloglu, Aysin

    2010-01-01

    Cyclophosphamide (CYC) has been the landmark in the treatment of lupus nephritis. However, long-term treatment with CYC is associated with significant side effects. We aimed to evaluate the efficacy of short-term intravenous (IV) CYC treatment as a remission induction treatment followed by azathioprine (AZA) or mycophenolate mofetil (MMF) as a maintenance treatment. Twenty patients (18 girls) with biopsy-proven class III (5) and IV (15) lupus nephritis were included in to the study. Detailed clinical and laboratory data and patient outcomes were evaluated. All patients received three methylprednisolone (MP) IV pulses, followed by oral prednisone 0.5-1 mg/kg per day and one IV pulse of CYC per month for 6 months. Azathioprine was started as a remission-maintaining treatment. In ten of 20 patients, treatment was switched to MMF. The mean age at the time of diagnosis was 16.11 +/- 3.49 years, and the mean duration of follow-up was 49.6 +/- 27 months. Fourteen patients (70%) had complete remission, three (15%) had partial remission, one (5%) continued to have active disease, and two (10%) progressed to end-stage renal disease. Nine of the patients (45%) with complete remission had received AZA, and switching to MMF increased complete remission rate (additional five patients; 25%). In conclusion, short-term (6-month) IV bolus CYC treatment followed by AZA is a safe and effective treatment in children with severe lupus nephritis, and using MMF increases remission rate in resistant cases.

  20. Long-Term Impact of Cyclosporin Reduction with MMF Treatment in Chronic Allograft Dysfunction: REFERENECE Study 3-Year Follow Up

    Directory of Open Access Journals (Sweden)

    L. Frimat

    2010-01-01

    Full Text Available Calcineurin inhibitor (CNI toxicity contributes to chronic allograft nephropathy (CAN. In the 2-year, randomized, study, we showed that 50% cyclosporin (CsA reduction in combination with mycophenolate mofetil (MMF treatment improves kidney function without increasing the risk for graft rejection/loss. To investigate the long-term effect of this regimen, we conducted a follow up study in 70 kidney transplant patients until 5 years after REFERENCE initiation. The improvement of kidney function was confirmed in the MMF group but not in the control group (CsA group. Four graft losses occurred, 2 in each group (graft survival in the MMF group 95.8% and 90.9% in control group. One death occurred in the control group. There was no statistically significant difference in the occurrence of serious adverse events or acute graft rejections. A limitation is the weak proportion of patient still remaining within the control group. On the other hand, REFERENCE focuses on the CsA regimen while opinions about the tacrolimus ones are still debated. In conclusion, CsA reduction in the presence of MMF treatment seems to maintain kidney function and is well tolerated in the long term.

  1. Long-Term Impact of Cyclosporin Reduction with MMF Treatment in Chronic Allograft Dysfunction: REFERENECE Study 3-Year Follow Up.

    Science.gov (United States)

    Frimat, L; Cassuto-Viguier, E; Provôt, F; Rostaing, L; Charpentier, B; Akposso, K; Moal, M C; Lang, P; Glotz, D; Caillard, S; Ducloux, D; Pouteil-Noble, C; Girardot-Seguin, S; Kessler, M

    2010-01-01

    Calcineurin inhibitor (CNI) toxicity contributes to chronic allograft nephropathy (CAN). In the 2-year, randomized, study, we showed that 50% cyclosporin (CsA) reduction in combination with mycophenolate mofetil (MMF) treatment improves kidney function without increasing the risk for graft rejection/loss. To investigate the long-term effect of this regimen, we conducted a follow up study in 70 kidney transplant patients until 5 years after REFERENCE initiation. The improvement of kidney function was confirmed in the MMF group but not in the control group (CsA group). Four graft losses occurred, 2 in each group (graft survival in the MMF group 95.8% and 90.9% in control group). One death occurred in the control group. There was no statistically significant difference in the occurrence of serious adverse events or acute graft rejections. A limitation is the weak proportion of patient still remaining within the control group. On the other hand, REFERENCE focuses on the CsA regimen while opinions about the tacrolimus ones are still debated. In conclusion, CsA reduction in the presence of MMF treatment seems to maintain kidney function and is well tolerated in the long term.

  2. Tarmo: A Framework for Parallelized Bounded Model Checking

    Directory of Open Access Journals (Sweden)

    Siert Wieringa

    2009-12-01

    Full Text Available This paper investigates approaches to parallelizing Bounded Model Checking (BMC for shared memory environments as well as for clusters of workstations. We present a generic framework for parallelized BMC named Tarmo. Our framework can be used with any incremental SAT encoding for BMC but for the results in this paper we use only the current state-of-the-art encoding for full PLTL. Using this encoding allows us to check both safety and liveness properties, contrary to an earlier work on distributing BMC that is limited to safety properties only. Despite our focus on BMC after it has been translated to SAT, existing distributed SAT solvers are not well suited for our application. This is because solving a BMC problem is not solving a set of independent SAT instances but rather involves solving multiple related SAT instances, encoded incrementally, where the satisfiability of each instance corresponds to the existence of a counterexample of a specific length. Our framework includes a generic architecture for a shared clause database that allows easy clause sharing between SAT solver threads solving various such instances. We present extensive experimental results obtained with multiple variants of our Tarmo implementation. Our shared memory variants have a significantly better performance than conventional single threaded approaches, which is a result that many users can benefit from as multi-core and multi-processor technology is widely available. Furthermore we demonstrate that our framework can be deployed in a typical cluster of workstations, where several multi-core machines are connected by a network.

  3. Strategic assessment of capacity consumption in railway networks: Framework and model

    DEFF Research Database (Denmark)

    Jensen, Lars Wittrup; Landex, Alex; Nielsen, Otto Anker

    2017-01-01

    In this paper, we develop a new framework for strategic planning purposes to calculate railway infrastructure occupation and capacity consumption in networks, independent of a timetable. Furthermore, a model implementing the framework is presented. In this model different train sequences are gene......In this paper, we develop a new framework for strategic planning purposes to calculate railway infrastructure occupation and capacity consumption in networks, independent of a timetable. Furthermore, a model implementing the framework is presented. In this model different train sequences...

  4. Model-Driven Policy Framework for Data Centers

    DEFF Research Database (Denmark)

    Caba, Cosmin Marius; Kentis, Angelos Mimidis; Soler, José

    2016-01-01

    . Moreover, the lack of simple solutions for managing the configuration and behavior of the DC components makes the DC hard to configure and slow in adapting to changes in business needs. In this paper, we propose a model-driven framework for policy-based management for DCs, to simplify not only the service......Data Centers (DCs) continue to become increasingly complex, due to comprising multiple functional entities (e.g. routing, orchestration). Managing the multitude of interconnected components in the DC becomes difficult and error prone, leading to slow service provisioning, lack of QoS support, etc...

  5. Generic modelling framework for economic analysis of battery systems

    DEFF Research Database (Denmark)

    You, Shi; Rasmussen, Claus Nygaard

    2011-01-01

    Deregulated electricity markets provide opportunities for Battery Systems (BS) to participate in energy arbitrage and ancillary services (regulation, operating reserves, contingency reserves, voltage regulation, power quality etc.). To evaluate the economic viability of BS with different business...... for battery cycle life estimation, since the cycle life plays a central role in the economic analysis of BS. To illustrate the modelling framework, a case study using a Sodium Sulfur Battery (NAS) system with 5-minute regulating service is performed. The economic performances of two dispatch scenarios, a so...

  6. Maxillo Mandibular Fixation in Edentulous Scenarios: Combined MMF Screws and Gunning Splints.

    Science.gov (United States)

    Chaudhary, Zainab; Sharma, Rakesh; Krishnan, Sriram

    2014-06-01

    A fracture of the maxillary or mandibular bone requires the afflicted to undergo a maxillo mandibular fixation for the establishment of pre traumatic occlusion. This process is quiet tedious and consumes a considerable period of time before any surgical procedure can commence. Such a situation can be complicated in case the individual with maxillomandibular fracture has sparse or absent dentition; for such cases a splint is fabricated or an erstwhile existing denture is used for maintaining a vertical jaw proportion. Stabilizing such splints to the jaw requires various invasive approaches that can bring into harm's way, adjacent soft tissue vital structures. We describe here an innovative technique combining the time tested method of the "gunning splint" and the advanced minimally invasive MMF screws for obtaining closed reduction in edentulous jaw fractures.

  7. Experimental video signals distribution MMF network based on IEEE 802.11 standard

    Science.gov (United States)

    Kowalczyk, Marcin; Maksymiuk, Lukasz; Siuzdak, Jerzy

    2014-11-01

    The article was focused on presentation the achievements in a scope of experimental research on transmission of digital video streams in the frame of specially realized for this purpose ROF (Radio over Fiber) network. Its construction was based on the merge of wireless IEEE 802.11 network, popularly referred as Wi-Fi, with a passive optical network PON based on multimode fibers MMF. The proposed approach can constitute interesting proposal in area of solutions in the scope of the systems monitoring extensive, within which is required covering of a large area with ensuring of a relatively high degree of immunity on the interferences transmitted signals from video IP cameras to the monitoring center and a high configuration flexibility (easily change the deployment of cameras) of such network.

  8. An Integrated Framework Advancing Membrane Protein Modeling and Design.

    Directory of Open Access Journals (Sweden)

    Rebecca F Alford

    2015-09-01

    Full Text Available Membrane proteins are critical functional molecules in the human body, constituting more than 30% of open reading frames in the human genome. Unfortunately, a myriad of difficulties in overexpression and reconstitution into membrane mimetics severely limit our ability to determine their structures. Computational tools are therefore instrumental to membrane protein structure prediction, consequently increasing our understanding of membrane protein function and their role in disease. Here, we describe a general framework facilitating membrane protein modeling and design that combines the scientific principles for membrane protein modeling with the flexible software architecture of Rosetta3. This new framework, called RosettaMP, provides a general membrane representation that interfaces with scoring, conformational sampling, and mutation routines that can be easily combined to create new protocols. To demonstrate the capabilities of this implementation, we developed four proof-of-concept applications for (1 prediction of free energy changes upon mutation; (2 high-resolution structural refinement; (3 protein-protein docking; and (4 assembly of symmetric protein complexes, all in the membrane environment. Preliminary data show that these algorithms can produce meaningful scores and structures. The data also suggest needed improvements to both sampling routines and score functions. Importantly, the applications collectively demonstrate the potential of combining the flexible nature of RosettaMP with the power of Rosetta algorithms to facilitate membrane protein modeling and design.

  9. A hybrid parallel framework for the cellular Potts model simulations

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Yi [Los Alamos National Laboratory; He, Kejing [SOUTH CHINA UNIV; Dong, Shoubin [SOUTH CHINA UNIV

    2009-01-01

    The Cellular Potts Model (CPM) has been widely used for biological simulations. However, most current implementations are either sequential or approximated, which can't be used for large scale complex 3D simulation. In this paper we present a hybrid parallel framework for CPM simulations. The time-consuming POE solving, cell division, and cell reaction operation are distributed to clusters using the Message Passing Interface (MPI). The Monte Carlo lattice update is parallelized on shared-memory SMP system using OpenMP. Because the Monte Carlo lattice update is much faster than the POE solving and SMP systems are more and more common, this hybrid approach achieves good performance and high accuracy at the same time. Based on the parallel Cellular Potts Model, we studied the avascular tumor growth using a multiscale model. The application and performance analysis show that the hybrid parallel framework is quite efficient. The hybrid parallel CPM can be used for the large scale simulation ({approx}10{sup 8} sites) of complex collective behavior of numerous cells ({approx}10{sup 6}).

  10. CIMS: A FRAMEWORK FOR INFRASTRUCTURE INTERDEPENDENCY MODELING AND ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    Donald D. Dudenhoeffer; May R. Permann; Milos Manic

    2006-12-01

    Today’s society relies greatly upon an array of complex national and international infrastructure networks such as transportation, utilities, telecommunication, and even financial networks. While modeling and simulation tools have provided insight into the behavior of individual infrastructure networks, a far less understood area is that of the interrelationships among multiple infrastructure networks including the potential cascading effects that may result due to these interdependencies. This paper first describes infrastructure interdependencies as well as presenting a formalization of interdependency types. Next the paper describes a modeling and simulation framework called CIMS© and the work that is being conducted at the Idaho National Laboratory (INL) to model and simulate infrastructure interdependencies and the complex behaviors that can result.

  11. A framework for modeling emerging diseases to inform management

    Science.gov (United States)

    Russell, Robin E.; Katz, Rachel A.; Richgels, Katherine L.D.; Walsh, Daniel P.; Grant, Evan

    2017-01-01

    The rapid emergence and reemergence of zoonotic diseases requires the ability to rapidly evaluate and implement optimal management decisions. Actions to control or mitigate the effects of emerging pathogens are commonly delayed because of uncertainty in the estimates and the predicted outcomes of the control tactics. The development of models that describe the best-known information regarding the disease system at the early stages of disease emergence is an essential step for optimal decision-making. Models can predict the potential effects of the pathogen, provide guidance for assessing the likelihood of success of different proposed management actions, quantify the uncertainty surrounding the choice of the optimal decision, and highlight critical areas for immediate research. We demonstrate how to develop models that can be used as a part of a decision-making framework to determine the likelihood of success of different management actions given current knowledge.

  12. A Building Model Framework for a Genetic Algorithm Multi-objective Model Predictive Control

    DEFF Research Database (Denmark)

    Arendt, Krzysztof; Ionesi, Ana; Jradi, Muhyiddine

    2016-01-01

    implemented only in few buildings. The following difficulties hinder the widespread usage of MPC: (1) significant model development time, (2) limited portability of models, (3) model computational demand. In the present study a new model development framework for an MPC system based on a Genetic Algorithm (GA...

  13. Longitudinal growth on an everolimus- versus an MMF-based steroid-free immunosuppressive regimen in paediatric renal transplant recipients.

    Science.gov (United States)

    Billing, Heiko; Burmeister, Greta; Plotnicki, Lukasz; Ahlenstiel, Thurid; Fichtner, Alexander; Sander, Anja; Höcker, Britta; Tönshoff, Burkhard; Pape, Lars

    2013-09-01

    Concerns have been raised that mammalian target of rapamycin inhibitors in pediatric transplant recipients might interfere with longitudinal bone growth by inhibition of growth factor signaling and growth plate chondrocyte proliferation. We therefore undertook a prospective nested, case-control study on longitudinal growth over 2 years in steroid-free pediatric renal transplant recipients. Fourteen patients on a steroid-free maintenance immunosuppressive regimen consisting of low-dose everolimus (EVR) in conjunction with low-dose cyclosporine (CsA) were compared to a matched cohort of 14 steroid-free patients on a standard dose mycophenolate mofetil (MMF) regimen in conjunction with a standard dose calcineurin inhibitor (CNI). The mean change in height standard deviation (SD) score in the first study year was 0.31 ± 0.71 SD score in the EVR group compared to 0.31 ± 0.64 SD score in the MMF group (P = 0.20). For the entire study period of 2 years, the change in height SD score in the EVR group was 0.43 ± 0.81 SDS compared to 0.75 ± 0.85 SDS in the MMF group (P = 0.32). The percentage of prepubertal patients experiencing catch-up growth, defined as an increase in height SD score ≥0.5 in 2 years, was similar in the EVR group (5/8, 65%) and the MMF group (6/8, 75%; P = 1.00). Longitudinal growth over 2 years in steroid-free pediatric patients on low-dose EVR and CsA is not different to that of a matched steroid-free control group on an immunosuppressive regimen with standard-dose CNI and MMF. Hence, low-dose EVR does not appear to negatively impact short-term growth in pediatric renal transplant recipients.

  14. An integrated modelling framework for neural circuits with multiple neuromodulators

    Science.gov (United States)

    Vemana, Vinith

    2017-01-01

    Neuromodulators are endogenous neurochemicals that regulate biophysical and biochemical processes, which control brain function and behaviour, and are often the targets of neuropharmacological drugs. Neuromodulator effects are generally complex partly owing to the involvement of broad innervation, co-release of neuromodulators, complex intra- and extrasynaptic mechanism, existence of multiple receptor subtypes and high interconnectivity within the brain. In this work, we propose an efficient yet sufficiently realistic computational neural modelling framework to study some of these complex behaviours. Specifically, we propose a novel dynamical neural circuit model that integrates the effective neuromodulator-induced currents based on various experimental data (e.g. electrophysiology, neuropharmacology and voltammetry). The model can incorporate multiple interacting brain regions, including neuromodulator sources, simulate efficiently and easily extendable to large-scale brain models, e.g. for neuroimaging purposes. As an example, we model a network of mutually interacting neural populations in the lateral hypothalamus, dorsal raphe nucleus and locus coeruleus, which are major sources of neuromodulator orexin/hypocretin, serotonin and norepinephrine/noradrenaline, respectively, and which play significant roles in regulating many physiological functions. We demonstrate that such a model can provide predictions of systemic drug effects of the popular antidepressants (e.g. reuptake inhibitors), neuromodulator antagonists or their combinations. Finally, we developed user-friendly graphical user interface software for model simulation and visualization for both fundamental sciences and pharmacological studies. PMID:28100828

  15. A python framework for environmental model uncertainty analysis

    Science.gov (United States)

    White, Jeremy; Fienen, Michael; Doherty, John E.

    2016-01-01

    We have developed pyEMU, a python framework for Environmental Modeling Uncertainty analyses, open-source tool that is non-intrusive, easy-to-use, computationally efficient, and scalable to highly-parameterized inverse problems. The framework implements several types of linear (first-order, second-moment (FOSM)) and non-linear uncertainty analyses. The FOSM-based analyses can also be completed prior to parameter estimation to help inform important modeling decisions, such as parameterization and objective function formulation. Complete workflows for several types of FOSM-based and non-linear analyses are documented in example notebooks implemented using Jupyter that are available in the online pyEMU repository. Example workflows include basic parameter and forecast analyses, data worth analyses, and error-variance analyses, as well as usage of parameter ensemble generation and management capabilities. These workflows document the necessary steps and provides insights into the results, with the goal of educating users not only in how to apply pyEMU, but also in the underlying theory of applied uncertainty quantification.

  16. Receptor modeling application framework for particle source apportionment.

    Science.gov (United States)

    Watson, John G; Zhu, Tan; Chow, Judith C; Engelbrecht, Johann; Fujita, Eric M; Wilson, William E

    2002-12-01

    Receptor models infer contributions from particulate matter (PM) source types using multivariate measurements of particle chemical and physical properties. Receptor models complement source models that estimate concentrations from emissions inventories and transport meteorology. Enrichment factor, chemical mass balance, multiple linear regression, eigenvector. edge detection, neural network, aerosol evolution, and aerosol equilibrium models have all been used to solve particulate air quality problems, and more than 500 citations of their theory and application document these uses. While elements, ions, and carbons were often used to apportion TSP, PM10, and PM2.5 among many source types, many of these components have been reduced in source emissions such that more complex measurements of carbon fractions, specific organic compounds, single particle characteristics, and isotopic abundances now need to be measured in source and receptor samples. Compliance monitoring networks are not usually designed to obtain data for the observables, locations, and time periods that allow receptor models to be applied. Measurements from existing networks can be used to form conceptual models that allow the needed monitoring network to be optimized. The framework for using receptor models to solve air quality problems consists of: (1) formulating a conceptual model; (2) identifying potential sources; (3) characterizing source emissions; (4) obtaining and analyzing ambient PM samples for major components and source markers; (5) confirming source types with multivariate receptor models; (6) quantifying source contributions with the chemical mass balance; (7) estimating profile changes and the limiting precursor gases for secondary aerosols; and (8) reconciling receptor modeling results with source models, emissions inventories, and receptor data analyses.

  17. Comparable Renal Function at 6 Months with Tacrolimus Combined with Fixed-Dose Sirolimus or MMF: Results of a Randomized Multicenter Trial in Renal Transplantation.

    Science.gov (United States)

    Van Gurp, Eveline; Bustamante, Jesus; Franco, Antonio; Rostaing, Lionel; Becker, Thomas; Rondeau, Eric; Czajkowski, Zenon; Rydzewski, Andrzej; Alarcon, Antonio; Bachleda, Petr; Samlik, Jiri; Burmeister, Dirk; Pallardo, Luis; Moal, Marie-Christine; Rutkowski, Boleslaw; Wlodarczyk, Zbigniew

    2010-01-01

    In a multicenter trial, renal transplant recipients were randomized to tacrolimus with fixed-dose sirolimus (Tac/SRL, N = 318) or tacrolimus with MMF (Tac/MMF, N = 316). Targeted tacrolimus trough levels were lower in the Tac/SRL group after day 14. The primary endpoint was renal function at 6 months using creatinine clearance (Cockcroft-Gault) and was comparable at 66.4 mL/min (SE 1.4) with Tac/SRL and at 65.2mL/min (SE 1.3) with Tac/MMF (completers). Biopsy-confirmed acute rejection was 15.1% (Tac/SRL) and 12.3% (Tac/MMF). In both groups, graft survival was 93% and patient survival was 99.0%. Premature withdrawal due to an adverse event was twice as high in the Tac/SRL group, 15.1% versus 6.3%. Hypercholesterolemia incidence was higher with Tac/SRL (P MMF (P 30 consecutive days in previously nondiabetic patients was 17.8%, Tac/SRL, and 24.8%, Tac/MMF. Evaluation at 6 months showed comparable renal function using tacrolimus/sirolimus and tacrolimus/MMF regimens.

  18. A Model-driven Framework for Educational Game Design

    Directory of Open Access Journals (Sweden)

    Bill Roungas

    2016-09-01

    Full Text Available Educational games are a class of serious games whose main purpose is to teach some subject to their players. Despite the many existing design frameworks, these games are too often created in an ad-hoc manner, and typically without the use of a game design document (GDD. We argue that a reason for this phenomenon is that current ways to structure, create and update GDDs do not increase the value of the artifact in the design and development process. As a solution, we propose a model-driven, web-based knowledge management environment that supports game designers in the creation of a GDD that accounts for and relates educational and entertainment game elements. The foundation of our approach is our devised conceptual model for educational games, which also defines the structure of the design environment. We present promising results from an evaluation of our environment with eight experts in serious games.

  19. A Bisimulation-based Hierarchical Framework for Software Development Models

    Directory of Open Access Journals (Sweden)

    Ping Liang

    2013-08-01

    Full Text Available Software development models have been ripen since the emergence of software engineering, like waterfall model, V-model, spiral model, etc. To ensure the successful implementation of those models, various metrics for software products and development process have been developed along, like CMMI, software metrics, and process re-engineering, etc. The quality of software products and processes can be ensured in consistence as much as possible and the abstract integrity of a software product can be achieved. However, in reality, the maintenance of software products is still high and even higher along with software evolution due to the inconsistence occurred by changes and inherent errors of software products. It is better to build up a robust software product that can sustain changes as many as possible. Therefore, this paper proposes a process algebra based hierarchical framework to extract an abstract equivalent of deliverable at the end of phases of a software product from its software development models. The process algebra equivalent of the deliverable is developed hierarchically with the development of the software product, applying bi-simulation to test run the deliverable of phases to guarantee the consistence and integrity of the software development and product in a trivially mathematical way. And an algorithm is also given to carry out the assessment of the phase deliverable in process algebra.  

  20. A Categorical Framework for Model Classification in the Geosciences

    Science.gov (United States)

    Hauhs, Michael; Trancón y Widemann, Baltasar; Lange, Holger

    2016-04-01

    Models have a mixed record of success in the geosciences. In meteorology, model development and implementation has been among the first and most successful examples of triggering computer technology in science. On the other hand, notorious problems such as the 'equifinality issue' in hydrology lead to a rather mixed reputation of models in other areas. The most successful models in geosciences are applications of dynamic systems theory to non-living systems or phenomena. Thus, we start from the hypothesis that the success of model applications relates to the influence of life on the phenomenon under study. We thus focus on the (formal) representation of life in models. The aim is to investigate whether disappointment in model performance is due to system properties such as heterogeneity and historicity of ecosystems, or rather reflects an abstraction and formalisation problem at a fundamental level. As a formal framework for this investigation, we use category theory as applied in computer science to specify behaviour at an interface. Its methods have been developed for translating and comparing formal structures among different application areas and seems highly suited for a classification of the current "model zoo" in the geosciences. The approach is rather abstract, with a high degree of generality but a low level of expressibility. Here, category theory will be employed to check the consistency of assumptions about life in different models. It will be shown that it is sufficient to distinguish just four logical cases to check for consistency of model content. All four cases can be formalised as variants of coalgebra-algebra homomorphisms. It can be demonstrated that transitions between the four variants affect the relevant observations (time series or spatial maps), the formalisms used (equations, decision trees) and the test criteria of success (prediction, classification) of the resulting model types. We will present examples from hydrology and ecology in

  1. An Extended Model Driven Framework for End-to-End Consistent Model Transformation

    Directory of Open Access Journals (Sweden)

    Mr. G. Ramesh

    2016-08-01

    Full Text Available Model Driven Development (MDD results in quick transformation from models to corresponding systems. Forward engineering features of modelling tools can help in generating source code from models. To build a robust system it is important to have consistency checking in the design models and the same between design model and the transformed implementation. Our framework named as Extensible Real Time Software Design Inconsistency Checker (XRTSDIC proposed in our previous papers supports consistency checking in design models. This paper focuses on automatic model transformation. An algorithm and defined transformation rules for model transformation from UML class diagram to ERD and SQL are being proposed. The model transformation bestows many advantages such as reducing cost of development, improving quality, enhancing productivity and leveraging customer satisfaction. Proposed framework has been enhanced to ensure that the transformed implementations conform to their model counterparts besides checking end-to-end consistency.

  2. Usage Intention Framework Model: A Fuzzy Logic Interpretation of the Classical Utaut Model

    Science.gov (United States)

    Sandaire, Johnny

    2009-01-01

    A fuzzy conjoint analysis (FCA: Turksen, 1992) model for enhancing management decision in the technology adoption domain was implemented as an extension to the UTAUT model (Venkatesh, Morris, Davis, & Davis, 2003). Additionally, a UTAUT-based Usage Intention Framework Model (UIFM) introduced a closed-loop feedback system. The empirical evidence…

  3. Participatory Model Construction and Model Use in Natural Resource Management: a Framework for Reflection

    NARCIS (Netherlands)

    Bots, P.W.G.; Van Daalen, C.E.

    2008-01-01

    In this article we propose a framework which can assist analysts in their reflection on the requirements for a participatory modelling exercise in natural resource management. Firstly, we distinguish different types of formal models which may be developed, ranging from models that focus on (bio)phys

  4. Usage Intention Framework Model: A Fuzzy Logic Interpretation of the Classical Utaut Model

    Science.gov (United States)

    Sandaire, Johnny

    2009-01-01

    A fuzzy conjoint analysis (FCA: Turksen, 1992) model for enhancing management decision in the technology adoption domain was implemented as an extension to the UTAUT model (Venkatesh, Morris, Davis, & Davis, 2003). Additionally, a UTAUT-based Usage Intention Framework Model (UIFM) introduced a closed-loop feedback system. The empirical evidence…

  5. An Integrated Hydro-Economic Modelling Framework to Evaluate Water Allocation Strategies I: Model Development.

    NARCIS (Netherlands)

    George, B.; Malano, H.; Davidson, B.; Hellegers, P.; Bharati, L.; Sylvain, M.

    2011-01-01

    In this paper an integrated modelling framework for water resources planning and management that can be used to carry out an analysis of alternative policy scenarios for water allocation and use is described. The modelling approach is based on integrating a network allocation model (REALM) and a soc

  6. DATA CONTEXT MODEL IN THE PRO- CESS INTEGRATION FRAMEWORK

    Institute of Scientific and Technical Information of China (English)

    ZHAO Bo; YAN Yan; NING Ruxin; LI Shiyun

    2008-01-01

    Process integration is the important aspect of product development process. The recent researches focus on project management, workflow management and process modeling. Based on the analysis of the process, product development process is divided into three levels according to different grains from macroscopy to microcosm. Our research concentrate on the workflow and the fine-grained design process. According to the need of representing the data and the relationships among them for process integration, context model is introduced, and its characters are analyzed. The tree-like structure of inheritance among context model's classes is illustrated; The relationships of reference among them are also explained. Then, extensible markup language (XML) file is used to depict these classes. A four-tier framework of process integration has been established, in which model-view-controller pattern is designed to realize the separation between context model and its various views. The integration of applications is applied by the encapsulation of enterprise's business logic as distributed services. The prototype system for the design of air filter is applied in an institute.

  7. Assessment of Solution Uncertainties in Single-Column Modeling Frameworks.

    Science.gov (United States)

    Hack, James J.; Pedretti, John A.

    2000-01-01

    Single-column models (SCMs) have been extensively promoted in recent years as an effective means to develop and test physical parameterizations targeted for more complex three-dimensional climate models. Although there are some clear advantages associated with single-column modeling, there are also some significant disadvantages, including the absence of large-scale feedbacks. Basic limitations of an SCM framework can make it difficult to interpret solutions, and at times contribute to rather striking failures to identify even first-order sensitivities as they would be observed in a global climate simulation. This manuscript will focus on one of the basic experimental approaches currently exploited by the single-column modeling community, with an emphasis on establishing the inherent uncertainties in the numerical solutions. The analysis will employ the standard physics package from the NCAR CCM3 and will illustrate the nature of solution uncertainties that arise from nonlinearities in parameterized physics. The results of this study suggest the need to make use of an ensemble methodology when conducting single-column modeling investigations.

  8. Structural uncertainty in watershed phosphorus modeling: Toward a stochastic framework

    Science.gov (United States)

    Chen, Lei; Gong, Yongwei; Shen, Zhenyao

    2016-06-01

    Structural uncertainty is an important source of model predictive errors, but few studies have been conducted on the error-transitivity from model structure to nonpoint source (NPS) prediction. In this study, we focused on the structural uncertainty caused by the algorithms and equations that are used to describe the phosphorus (P) cycle at the watershed scale. The sensitivity of simulated P to each algorithm/equation was quantified using the Soil and Water Assessment Tool (SWAT) in the Three Gorges Reservoir Area, China. The results indicated that the ratios of C:N and P:N for humic materials, as well as the algorithm of fertilization and P leaching contributed the largest output uncertainties. In comparison, the initiation of inorganic P in the soil layer and the transformation algorithm between P pools are less sensitive for the NPS-P predictions. In addition, the coefficient of variation values were quantified as 0.028-0.086, indicating that the structure-induced uncertainty is minor compared to NPS-P prediction uncertainty caused by the model input and parameters. Using the stochastic framework, the cumulative probability of simulated NPS-P data provided a trade-off between expenditure burden and desired risk. In this sense, this paper provides valuable information for the control of model structural uncertainty, and can be extrapolated to other model-based studies.

  9. A Data Driven Framework for Integrating Regional Climate Models

    Science.gov (United States)

    Lansing, C.; Kleese van Dam, K.; Liu, Y.; Elsethagen, T.; Guillen, Z.; Stephan, E.; Critchlow, T.; Gorton, I.

    2012-12-01

    There are increasing needs for research addressing complex climate sensitive issues of concern to decision-makers and policy planners at a regional level. Decisions about allocating scarce water across competing municipal, agricultural, and ecosystem demands is just one of the challenges ahead, along with decisions regarding competing land use priorities such as biofuels, food, and species habitat. Being able to predict the extent of future climate change in the context of introducing alternative energy production strategies requires a new generation of modeling capabilities. We will also need more complete representations of human systems at regional scales, incorporating the influences of population centers, land use, agriculture and existing and planned electrical demand and generation infrastructure. At PNNL we are working towards creating a first-of-a-kind capability known as the Integrated Regional Earth System Model (iRESM). The fundamental goal of the iRESM initiative is the critical analyses of the tradeoffs and consequences of decision and policy making for integrated human and environmental systems. This necessarily combines different scientific processes, bridging different temporal and geographic scales and resolving the semantic differences between them. To achieve this goal, iRESM is developing a modeling framework and supporting infrastructure that enable the scientific team to evaluate different scenarios in light of specific stakeholder questions such as "How do regional changes in mean climate states and climate extremes affect water storage and energy consumption and how do such decisions influence possible mitigation and carbon management schemes?" The resulting capability will give analysts a toolset to gain insights into how regional economies can respond to climate change mitigation policies and accelerated deployment of alternative energy technologies. The iRESM framework consists of a collection of coupled models working with high

  10. A modelling framework to simulate foliar fungal epidemics using functional-structural plant models.

    Science.gov (United States)

    Garin, Guillaume; Fournier, Christian; Andrieu, Bruno; Houlès, Vianney; Robert, Corinne; Pradal, Christophe

    2014-09-01

    Sustainable agriculture requires the identification of new, environmentally responsible strategies of crop protection. Modelling of pathosystems can allow a better understanding of the major interactions inside these dynamic systems and may lead to innovative protection strategies. In particular, functional-structural plant models (FSPMs) have been identified as a means to optimize the use of architecture-related traits. A current limitation lies in the inherent complexity of this type of modelling, and thus the purpose of this paper is to provide a framework to both extend and simplify the modelling of pathosystems using FSPMs. Different entities and interactions occurring in pathosystems were formalized in a conceptual model. A framework based on these concepts was then implemented within the open-source OpenAlea modelling platform, using the platform's general strategy of modelling plant-environment interactions and extending it to handle plant interactions with pathogens. New developments include a generic data structure for representing lesions and dispersal units, and a series of generic protocols to communicate with objects representing the canopy and its microenvironment in the OpenAlea platform. Another development is the addition of a library of elementary models involved in pathosystem modelling. Several plant and physical models are already available in OpenAlea and can be combined in models of pathosystems using this framework approach. Two contrasting pathosystems are implemented using the framework and illustrate its generic utility. Simulations demonstrate the framework's ability to simulate multiscaled interactions within pathosystems, and also show that models are modular components within the framework and can be extended. This is illustrated by testing the impact of canopy architectural traits on fungal dispersal. This study provides a framework for modelling a large number of pathosystems using FSPMs. This structure can accommodate both

  11. A Theoretical Framework for Physics Education Research: Modeling Student Thinking

    CERN Document Server

    Redish, E F

    2004-01-01

    Education is a goal-oriented field. But if we want to treat education scientifically so we can accumulate, evaluate, and refine what we learn, then we must develop a theoretical framework that is strongly rooted in objective observations and through which different theoretical models of student thinking can be compared. Much that is known in the behavioral sciences is robust and observationally based. In this paper, I draw from a variety of fields ranging from neuroscience to sociolinguistics to propose an over-arching theoretical framework that allows us to both make sense of what we see in the classroom and to compare a variety of specific theoretical approaches. My synthesis is organized around an analysis of the individual's cognition and how it interacts with the environment. This leads to a two level system, a knowledge-structure level where associational patterns dominate, and a control-structure level where one can describe expectations and epistemology. For each level, I sketch some plausible startin...

  12. TP-model transformation-based-control design frameworks

    CERN Document Server

    Baranyi, Péter

    2016-01-01

    This book covers new aspects and frameworks of control, design, and optimization based on the TP model transformation and its various extensions. The author outlines the three main steps of polytopic and LMI based control design: 1) development of the qLPV state-space model, 2) generation of the polytopic model; and 3) application of LMI to derive controller and observer. He goes on to describe why literature has extensively studied LMI design, but has not focused much on the second step, in part because the generation and manipulation of the polytopic form was not tractable in many cases. The author then shows how the TP model transformation facilitates this second step and hence reveals new directions, leading to powerful design procedures and the formulation of new questions. The chapters of this book, and the complex dynamical control tasks which they cover, are organized so as to present and analyze the beneficial aspect of the family of approaches (control, design, and optimization). Additionally, the b...

  13. A Multiple Reaction Modelling Framework for Microbial Electrochemical Technologies

    Science.gov (United States)

    Oyetunde, Tolutola; Sarma, Priyangshu M.; Ahmad, Farrukh; Rodríguez, Jorge

    2017-01-01

    A mathematical model for the theoretical evaluation of microbial electrochemical technologies (METs) is presented that incorporates a detailed physico-chemical framework, includes multiple reactions (both at the electrodes and in the bulk phase) and involves a variety of microbial functional groups. The model is applied to two theoretical case studies: (i) A microbial electrolysis cell (MEC) for continuous anodic volatile fatty acids (VFA) oxidation and cathodic VFA reduction to alcohols, for which the theoretical system response to changes in applied voltage and VFA feed ratio (anode-to-cathode) as well as membrane type are investigated. This case involves multiple parallel electrode reactions in both anode and cathode compartments; (ii) A microbial fuel cell (MFC) for cathodic perchlorate reduction, in which the theoretical impact of feed flow rates and concentrations on the overall system performance are investigated. This case involves multiple electrode reactions in series in the cathode compartment. The model structure captures interactions between important system variables based on first principles and provides a platform for the dynamic description of METs involving electrode reactions both in parallel and in series and in both MFC and MEC configurations. Such a theoretical modelling approach, largely based on first principles, appears promising in the development and testing of MET control and optimization strategies. PMID:28054959

  14. A Smart Modeling Framework for Integrating BMI-enabled Models as Web Services

    Science.gov (United States)

    Jiang, P.; Elag, M.; Kumar, P.; Peckham, S. D.; Liu, R.; Marini, L.; Hsu, L.

    2015-12-01

    Serviced-oriented computing provides an opportunity to couple web service models using semantic web technology. Through this approach, models that are exposed as web services can be conserved in their own local environment, thus making it easy for modelers to maintain and update the models. In integrated modeling, the serviced-oriented loose-coupling approach requires (1) a set of models as web services, (2) the model metadata describing the external features of a model (e.g., variable name, unit, computational grid, etc.) and (3) a model integration framework. We present the architecture of coupling web service models that are self-describing by utilizing a smart modeling framework. We expose models that are encapsulated with CSDMS (Community Surface Dynamics Modeling System) Basic Model Interfaces (BMI) as web services. The BMI-enabled models are self-describing by uncovering models' metadata through BMI functions. After a BMI-enabled model is serviced, a client can initialize, execute and retrieve the meta-information of the model by calling its BMI functions over the web. Furthermore, a revised version of EMELI (Peckham, 2015), an Experimental Modeling Environment for Linking and Interoperability, is chosen as the framework for coupling BMI-enabled web service models. EMELI allows users to combine a set of component models into a complex model by standardizing model interface using BMI as well as providing a set of utilities smoothing the integration process (e.g., temporal interpolation). We modify the original EMELI so that the revised modeling framework is able to initialize, execute and find the dependencies of the BMI-enabled web service models. By using the revised EMELI, an example will be presented on integrating a set of topoflow model components that are BMI-enabled and exposed as web services. Reference: Peckham, S.D. (2014) EMELI 1.0: An experimental smart modeling framework for automatic coupling of self-describing models, Proceedings of HIC 2014

  15. A FRAMEWORK FOR AN OPEN SOURCE GEOSPATIAL CERTIFICATION MODEL

    Directory of Open Access Journals (Sweden)

    T. U. R. Khan

    2016-06-01

    Full Text Available The geospatial industry is forecasted to have an enormous growth in the forthcoming years and an extended need for well-educated workforce. Hence ongoing education and training play an important role in the professional life. Parallel, in the geospatial and IT arena as well in the political discussion and legislation Open Source solutions, open data proliferation, and the use of open standards have an increasing significance. Based on the Memorandum of Understanding between International Cartographic Association, OSGeo Foundation, and ISPRS this development led to the implementation of the ICA-OSGeo-Lab imitative with its mission “Making geospatial education and opportunities accessible to all”. Discussions in this initiative and the growth and maturity of geospatial Open Source software initiated the idea to develop a framework for a worldwide applicable Open Source certification approach. Generic and geospatial certification approaches are already offered by numerous organisations, i.e., GIS Certification Institute, GeoAcademy, ASPRS, and software vendors, i. e., Esri, Oracle, and RedHat. They focus different fields of expertise and have different levels and ways of examination which are offered for a wide range of fees. The development of the certification framework presented here is based on the analysis of diverse bodies of knowledge concepts, i.e., NCGIA Core Curriculum, URISA Body Of Knowledge, USGIF Essential Body Of Knowledge, the “Geographic Information: Need to Know", currently under development, and the Geospatial Technology Competency Model (GTCM. The latter provides a US American oriented list of the knowledge, skills, and abilities required of workers in the geospatial technology industry and influenced essentially the framework of certification. In addition to the theoretical analysis of existing resources the geospatial community was integrated twofold. An online survey about the relevance of Open Source was performed and

  16. a Framework for AN Open Source Geospatial Certification Model

    Science.gov (United States)

    Khan, T. U. R.; Davis, P.; Behr, F.-J.

    2016-06-01

    The geospatial industry is forecasted to have an enormous growth in the forthcoming years and an extended need for well-educated workforce. Hence ongoing education and training play an important role in the professional life. Parallel, in the geospatial and IT arena as well in the political discussion and legislation Open Source solutions, open data proliferation, and the use of open standards have an increasing significance. Based on the Memorandum of Understanding between International Cartographic Association, OSGeo Foundation, and ISPRS this development led to the implementation of the ICA-OSGeo-Lab imitative with its mission "Making geospatial education and opportunities accessible to all". Discussions in this initiative and the growth and maturity of geospatial Open Source software initiated the idea to develop a framework for a worldwide applicable Open Source certification approach. Generic and geospatial certification approaches are already offered by numerous organisations, i.e., GIS Certification Institute, GeoAcademy, ASPRS, and software vendors, i. e., Esri, Oracle, and RedHat. They focus different fields of expertise and have different levels and ways of examination which are offered for a wide range of fees. The development of the certification framework presented here is based on the analysis of diverse bodies of knowledge concepts, i.e., NCGIA Core Curriculum, URISA Body Of Knowledge, USGIF Essential Body Of Knowledge, the "Geographic Information: Need to Know", currently under development, and the Geospatial Technology Competency Model (GTCM). The latter provides a US American oriented list of the knowledge, skills, and abilities required of workers in the geospatial technology industry and influenced essentially the framework of certification. In addition to the theoretical analysis of existing resources the geospatial community was integrated twofold. An online survey about the relevance of Open Source was performed and evaluated with 105

  17. A framework of modeling detector systems for computed tomography simulations

    Science.gov (United States)

    Youn, H.; Kim, D.; Kim, S. H.; Kam, S.; Jeon, H.; Nam, J.; Kim, H. K.

    2016-01-01

    Ultimate development in computed tomography (CT) technology may be a system that can provide images with excellent lesion conspicuity with the patient dose as low as possible. Imaging simulation tools have been cost-effectively used for these developments and will continue. For a more accurate and realistic imaging simulation, the signal and noise propagation through a CT detector system has been modeled in this study using the cascaded linear-systems theory. The simulation results are validated in comparisons with the measured results using a laboratory flat-panel micro-CT system. Although the image noise obtained from the simulations at higher exposures is slightly smaller than that obtained from the measurements, the difference between them is reasonably acceptable. According to the simulation results for various exposure levels and additive electronic noise levels, x-ray quantum noise is more dominant than the additive electronic noise. The framework of modeling a CT detector system suggested in this study will be helpful for the development of an accurate and realistic projection simulation model.

  18. A Production Model for Construction: A Theoretical Framework

    Directory of Open Access Journals (Sweden)

    Ricardo Antunes

    2015-03-01

    Full Text Available The building construction industry faces challenges, such as increasing project complexity and scope requirements, but shorter deadlines. Additionally, economic uncertainty and rising business competition with a subsequent decrease in profit margins for the industry demands the development of new approaches to construction management. However, the building construction sector relies on practices based on intuition and experience, overlooking the dynamics of its production system. Furthermore, researchers maintain that the construction industry has no history of the application of mathematical approaches to model and manage production. Much work has been carried out on how manufacturing practices apply to construction projects, mostly lean principles. Nevertheless, there has been little research to understand the fundamental mechanisms of production in construction. This study develops an in-depth literature review to examine the existing knowledge about production models and their characteristics in order to establish a foundation for dynamic production systems management in construction. As a result, a theoretical framework is proposed, which will be instrumental in the future development of mathematical production models aimed at predicting the performance and behaviour of dynamic project-based systems in construction.

  19. A unified framework for benchmark dose estimation applied to mixed models and model averaging

    DEFF Research Database (Denmark)

    Ritz, Christian; Gerhard, Daniel; Hothorn, Ludwig A.

    2013-01-01

    This article develops a framework for benchmark dose estimation that allows intrinsically nonlinear dose-response models to be used for continuous data in much the same way as is already possible for quantal data. This means that the same dose-response model equations may be applied to both...

  20. Flexible modeling frameworks to replace small ensembles of hydrological models and move toward large ensembles?

    Science.gov (United States)

    Addor, Nans; Clark, Martyn P.; Mizukami, Naoki

    2017-04-01

    Climate change impacts on hydrological processes are typically assessed using small ensembles of hydrological models. That is, a handful of hydrological models are typically driven by a larger number of climate models. Such a setup has several limitations. Because the number of hydrological models is small, only a small proportion of the model space is sampled, likely leading to an underestimation of the uncertainties in the projections. Further, sampling is arbitrary: although hydrological models should be selected to provide a representative sample of existing models (in terms of complexity and governing hypotheses), they are instead usually selected based on legacy reasons. Furthermore, running several hydrological models currently constitutes a practical challenge because each model must be setup and calibrated individually. Finally, and probably most importantly, the differences between the projected impacts cannot be directly related to differences between hydrological models, because the models are different in almost every possible aspect. We are hence in a situation in which different hydrological models deliver different projections, but for reasons that are mostly unclear, and in which the uncertainty in the projections is probably underestimated. To overcome these limitations, we are experimenting with the flexible modeling framework FUSE (Framework for Understanding Model Errors). FUSE enables to construct conceptual models piece by piece (in a "pick and mix" approach), so it can be used to generate a large number of models that mimic existing models and/or models that differ from other models in single targeted respect (e.g. how baseflow is generated). FUSE hence allows for controlled modeling experiments, and for a more systematic and exhaustive sampling of the model space. Here we explore climate change impacts over the contiguous USA on a 12km grid using two groups of three models: the first group involves the commonly used models VIC, PRMS and HEC

  1. Acid deposition: decision framework. Volume 1. Description of conceptual framework and decision-tree models. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Balson, W.E.; Boyd, D.W.; North, D.W.

    1982-08-01

    Acid precipitation and dry deposition of acid materials have emerged as an important environmental issue affecting the electric utility industry. This report presents a framework for the analysis of decisions on acid deposition. The decision framework is intended as a means of summarizing scientific information and uncertainties on the relation between emissions from electric utilities and other sources, acid deposition, and impacts on ecological systems. The methodology for implementing the framework is that of decision analysis, which provides a quantitative means of analyzing decisions under uncertainty. The decisions of interest include reductions in sulfur oxide and other emissions thought to be precursors of acid deposition, mitigation of acid deposition impacts through means such as liming of waterways and soils, and choice of strategies for research. The report first gives an overview of the decision framework and explains the decision analysis methods with a simplified caricature example. The state of scientific information and the modeling assumptions for the framework are then discussed for the three main modules of the framework: emissions and control technologies; long-range transport and chemical conversion in the atmosphere; and ecological impacts. The report then presents two versions of a decision tree model that implements the decision framework. The basic decision tree addresses decisions on emissions control and mitigation in the immediate future and a decade hence, and it includes uncertainties in the long-range transport and ecological impacts. The research emphasis decision tree addresses the effect of research funding on obtaining new information as the basis for future decisions. Illustrative data and calculations using the decision tree models are presented.

  2. AN INTEGRATED MODELING FRAMEWORK FOR CARBON MANAGEMENT TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    Anand B. Rao; Edward S. Rubin; Michael B. Berkenpas

    2004-03-01

    CO{sub 2} capture and storage (CCS) is gaining widespread interest as a potential method to control greenhouse gas emissions from fossil fuel sources, especially electric power plants. Commercial applications of CO{sub 2} separation and capture technologies are found in a number of industrial process operations worldwide. Many of these capture technologies also are applicable to fossil fuel power plants, although applications to large-scale power generation remain to be demonstrated. This report describes the development of a generalized modeling framework to assess alternative CO{sub 2} capture and storage options in the context of multi-pollutant control requirements for fossil fuel power plants. The focus of the report is on post-combustion CO{sub 2} capture using amine-based absorption systems at pulverized coal-fired plants, which are the most prevalent technology used for power generation today. The modeling framework builds on the previously developed Integrated Environmental Control Model (IECM). The expanded version with carbon sequestration is designated as IECM-cs. The expanded modeling capability also includes natural gas combined cycle (NGCC) power plants and integrated coal gasification combined cycle (IGCC) systems as well as pulverized coal (PC) plants. This report presents details of the performance and cost models developed for an amine-based CO{sub 2} capture system, representing the baseline of current commercial technology. The key uncertainties and variability in process design, performance and cost parameters which influence the overall cost of carbon mitigation also are characterized. The new performance and cost models for CO{sub 2} capture systems have been integrated into the IECM-cs, along with models to estimate CO{sub 2} transport and storage costs. The CO{sub 2} control system also interacts with other emission control technologies such as flue gas desulfurization (FGD) systems for SO{sub 2} control. The integrated model is applied to

  3. Retrofitting Non-Cognitive-Diagnostic Reading Assessment under the Generalized DINA Model Framework

    Science.gov (United States)

    Chen, Huilin; Chen, Jinsong

    2016-01-01

    Cognitive diagnosis models (CDMs) are psychometric models developed mainly to assess examinees' specific strengths and weaknesses in a set of skills or attributes within a domain. By adopting the Generalized-DINA model framework, the recently developed general modeling framework, we attempted to retrofit the PISA reading assessments, a…

  4. Model-Based Reasoning in the Physics Laboratory: Framework and Initial Results

    Science.gov (United States)

    Zwickl, Benjamin M.; Hu, Dehui; Finkelstein, Noah; Lewandowski, H. J.

    2015-01-01

    We review and extend existing frameworks on modeling to develop a new framework that describes model-based reasoning in introductory and upper-division physics laboratories. Constructing and using models are core scientific practices that have gained significant attention within K-12 and higher education. Although modeling is a broadly applicable…

  5. 25 Gb/s transmission over 820 m of MMF using a multimode launch from an integrated silicon photonics transceiver.

    Science.gov (United States)

    Chen, Xin; Bickham, Scott R; Liu, Hai-Feng; Dosunmu, Olufemi I; Hurley, Jason E; Li, Ming-Jun

    2014-01-27

    A new high bandwidth bend-insensitive MMF optimized for 1310 nm is designed and characterized. 25 Gb/s transmission over a record 820 m length using a multimode launch from an integrated SiPh transceiver at 1310 nm through the new fiber is demonstrated with a power penalty of 3.4 dB at 10(-12) BER. Detailed characteristics of the fiber and transceiver are presented along with BER measurements.

  6. A Global Modeling Framework for Plasma Kinetics: Development and Applications

    Science.gov (United States)

    Parsey, Guy Morland

    The modern study of plasmas, and applications thereof, has developed synchronously with com- puter capabilities since the mid-1950s. Complexities inherent to these charged-particle, many- body, systems have resulted in the development of multiple simulation methods (particle-in-cell, fluid, global modeling, etc.) in order to both explain observed phenomena and predict outcomes of plasma applications. Recognizing that different algorithms are chosen to best address specific topics of interest, this thesis centers around the development of an open-source global model frame- work for the focused study of non-equilibrium plasma kinetics. After verification and validation of the framework, it was used to study two physical phenomena: plasma-assisted combustion and the recently proposed optically-pumped rare gas metastable laser. Global models permeate chemistry and plasma science, relying on spatial averaging to focus attention on the dynamics of reaction networks. Defined by a set of species continuity and energy conservation equations, the required data and constructed systems are conceptually similar across most applications, providing a light platform for exploratory and result-search parameter scan- ning. Unfortunately, it is common practice for custom code to be developed for each application-- an enormous duplication of effort which negatively affects the quality of the software produced. Presented herein, the Python-based Kinetic Global Modeling framework (KGMf) was designed to support all modeling phases: collection and analysis of reaction data, construction of an exportable system of model ODEs, and a platform for interactive evaluation and post-processing analysis. A symbolic ODE system is constructed for interactive manipulation and generation of a Jacobian, both of which are compiled as operation-optimized C-code. Plasma-assisted combustion and ignition (PAC/PAI) embody the modernization of burning fuel by opening up new avenues of control and optimization

  7. Effective 100 Gb/s IM/DD 850-nm Multi- and Single-Mode VCSEL Transmission Through OM4 MMF

    DEFF Research Database (Denmark)

    Puerta Ramírez, Rafael; Agustin, Mikel; Chorchos, Lukasz

    2017-01-01

    of OM4 multimode fiber (MMF) using a multimode VCSEL at 850 nm, and up to 100 m of OM4 MMF using a single-mode VCSEL at 850 nm. Measured bit error rates were below 7% overhead forward error correction limit of 3.8e−03, thus, achieving an effective bit rate of 100.5 Gb/s. These successful transmissions...

  8. Young diabetics' compliance in the framework of the MIMIC model.

    Science.gov (United States)

    Kyngäs, H; Hentinen, M; Koivukangas, P; Ohinmaa, A

    1996-11-01

    The compliance of 346 young diabetics aged 13-17 years with health regimens is analysed in the framework of a MIMIC (multiple indicators, multiple causes) model. The data were compiled by means of a questionnaire on compliance, conditions for compliance, the meaning attached to treatment and the impact of the disease, and the model constructed using the LISREL VII programme, treating compliance as an unobserved variable formulated in terms of observed causes (x-variables) and observed indicators (y-variables). The resulting solutions are entirely satisfactory. The goodness-of-fit index is 0.983, the root mean square residual 0.058 and the chi-squared statistic 43.35 (P compliance to be indicated by self-care behaviour, responsibility for treatment, intention to pursue the treatment and collaboration with the physician, and to be greatly determined by motivation, experience of the results of treatment and having the energy and will-power to pursue the treatment and, to a lesser extent, by a sense of normality and fear.

  9. Smart licensing and environmental flows: Modeling framework and sensitivity testing

    Science.gov (United States)

    Wilby, R. L.; Fenn, C. R.; Wood, P. J.; Timlett, R.; Lequesne, T.

    2011-12-01

    Adapting to climate change is just one among many challenges facing river managers. The response will involve balancing the long-term water demands of society with the changing needs of the environment in sustainable and cost effective ways. This paper describes a modeling framework for evaluating the sensitivity of low river flows to different configurations of abstraction licensing under both historical climate variability and expected climate change. A rainfall-runoff model is used to quantify trade-offs among environmental flow (e-flow) requirements, potential surface and groundwater abstraction volumes, and the frequency of harmful low-flow conditions. Using the River Itchen in southern England as a case study it is shown that the abstraction volume is more sensitive to uncertainty in the regional climate change projection than to the e-flow target. It is also found that "smarter" licensing arrangements (involving a mix of hands off flows and "rising block" abstraction rules) could achieve e-flow targets more frequently than conventional seasonal abstraction limits, with only modest reductions in average annual yield, even under a hotter, drier climate change scenario.

  10. Python framework for kinetic modeling of electronically excited reaction pathways

    Science.gov (United States)

    Verboncoeur, John; Parsey, Guy; Guclu, Yaman; Christlieb, Andrew

    2012-10-01

    The use of plasma energy to enhance and control the chemical reactions during combustion, a technology referred to as ``plasma assisted combustion'' (PAC), can result in a variety of beneficial effects: e.g. stable lean operation, pollution reduction, and wider range of p-T operating conditions. While experimental evidence abounds, theoretical understanding of PAC is at best incomplete, and numerical tools still lack in reliable predictive capabilities. In the context of a joint experimental-numerical effort at Michigan State University, we present here an open-source modular Python framework dedicated to the dynamic optimization of non-equilibrium PAC systems. Multiple sources of experimental reaction data, e.g. reaction rates, cross-sections and oscillator strengths, are used in order to quantify the effect of data uncertainty and limiting assumptions. A collisional-radiative model (CRM) is implemented to organize reactions by importance and as a potential means of measuring a non-Maxwellian electron energy distribution function (EEDF), when coupled to optical emission spectroscopy data. Finally, we explore scaling laws in PAC parameter space using a kinetic global model (KGM) accelerated with CRM optimized reaction sequences and sparse stiff integrators.

  11. Data Self-Recalibration and Mixture Mass Fingerprint Searching (DASER-MMF) to enhance protein identification within complex mixtures.

    Science.gov (United States)

    Danell, Ryan M; Ouvry-Patat, Severine A; Scarlett, Cameron O; Speir, J Paul; Borchers, Christoph H

    2008-12-01

    A novel algorithm based on Data Self-Recalibration and a subsequent Mixture Mass Fingerprint search (DASER-MMF) has been developed to improve the performance of protein identification from online 1D and 2D-LC-MS/MS experiments conducted on high-resolution mass spectrometers. Recalibration of 40% to 75% of the MS spectra in a human serum dataset is demonstrated with average errors of 0.3 +/- 0.3 ppm, regardless of the original calibration quality. With simple protein mixtures, the MMF search identifies new proteins not found in the MS/MS based search and increases the sequence coverage for identified proteins by six times. The high mass accuracy allows proteins to be identified with as little as three peptide mass hits. When applied to very complex samples, the MMF search shows less dramatic performance improvements. However, refinements such as additional discriminating factors utilized within the search space provide significant gains in protein identification ability and indicate that further enhancements are possible in this realm.

  12. A modeling and simulation framework for electrokinetic nanoparticle treatment

    Science.gov (United States)

    Phillips, James

    2011-12-01

    The focus of this research is to model and provide a simulation framework for the packing of differently sized spheres within a hard boundary. The novel contributions of this dissertation are the cylinders of influence (COI) method and sectoring method implementations. The impetus for this research stems from modeling electrokinetic nanoparticle (EN) treatment, which packs concrete pores with differently sized nanoparticles. We show an improved speed of the simulation compared to previously published results of EN treatment simulation while obtaining similar porosity reduction results. We mainly focused on readily, commercially available particle sizes of 2 nm and 20 nm particles, but have the capability to model other sizes. Our simulation has graphical capabilities and can provide additional data unobtainable from physical experimentation. The data collected has a median of 0.5750 and a mean of 0.5504. The standard error is 0.0054 at alpha = 0.05 for a 95% confidence interval of 0.5504 +/- 0.0054. The simulation has produced maximum packing densities of 65% and minimum packing densities of 34%. Simulation data are analyzed using linear regression via the R statistical language to obtain two equations: one that describes porosity reduction based on all cylinder and particle characteristics, and another that focuses on describing porosity reduction based on cylinder diameter for 2 and 20 nm particles into pores of 100 nm height. Simulation results are similar to most physical results obtained from MIP and WLR. Some MIP results do not fall within the simulation limits; however, this is expected as MIP has been documented to be an inaccurate measure of pore distribution and porosity of concrete. Despite the disagreement between WLR and MIP, there is a trend that porosity reduction is higher two inches from the rebar as compared to the rebar-concrete interface. The simulation also detects a higher porosity reduction further from the rebar. This may be due to particles

  13. Modelling supported driving as an optimal control cycle: Framework and model characteristics

    CERN Document Server

    Wang, Meng; Daamen, Winnie; Hoogendoorn, Serge P; van Arem, Bart

    2014-01-01

    Driver assistance systems support drivers in operating vehicles in a safe, comfortable and efficient way, and thus may induce changes in traffic flow characteristics. This paper puts forward a receding horizon control framework to model driver assistance and cooperative systems. The accelerations of automated vehicles are controlled to optimise a cost function, assuming other vehicles driving at stationary conditions over a prediction horizon. The flexibility of the framework is demonstrated with controller design of Adaptive Cruise Control (ACC) and Cooperative ACC (C-ACC) systems. The proposed ACC and C-ACC model characteristics are investigated analytically, with focus on equilibrium solutions and stability properties. The proposed ACC model produces plausible human car-following behaviour and is unconditionally locally stable. By careful tuning of parameters, the ACC model generates similar stability characteristics as human driver models. The proposed C-ACC model results in convective downstream and abso...

  14. EC-MPS permits lower gastrointestinal symptom burden despite higher MPA exposure in patients with severe MMF-related gastrointestinal side-effects.

    Science.gov (United States)

    Sabbatini, Massimo; Capone, Domenico; Gallo, Riccardo; Pisani, Antonio; Polichetti, Giuliano; Tarantino, Giovanni; Gentile, Antonio; Rotaia, Eliana; Federico, Stefano

    2009-10-01

    Gastrointestinal (GI) adverse events in renal transplant patients are a common cause of mycophenolate mofetil (MMF) dose reductions, which result in an increased risk of graft rejection because of a low immunosuppression. This study investigated whether conversion from MMF to enteric-coated mycophenolate sodium (EC-MPS) in renal transplant patients with serious GI side-effects, alleviated these symptoms and allowed administration of higher doses of EC-MPS. Nineteen renal transplant patients with severe MMF-related GI side-effects underwent a progressive reduction in MMF dose until symptoms disappeared. At this point, 12-h AUC(MMF) was evaluated and patients were shifted to an equimolar dose of EC-MPS. The EC-MPS dose was then progressively increased until the highest recommended dose was reached or GI symptoms re-appeared. Four weeks post-conversion, AUC(EC-MPS) was determined. Conversion led to a mean increase in EC-MPS dose of 68% (P MPS dose could not be increased because of the prompt insurgence of GI symptoms. Renal function and biochemical parameters remained stable post-conversion and no rejection episodes occurred. These findings suggest that, in selected patients, EC-MPS may be better tolerated than MMF when GI symptoms are particularly important and permits higher mycophenolic acid exposure, when required.

  15. Digital Moon: A three-dimensional framework for lunar modeling

    Science.gov (United States)

    Paige, D. A.; Elphic, R. C.; Foote, E. J.; Meeker, S. R.; Siegler, M. A.; Vasavada, A. R.

    2009-12-01

    The Moon has a complex three-dimensional shape with significant large-scale and small-scale topographic relief. The Moon’s topography largely controls the distribution of incident solar radiation, as well as the scattered solar and infrared radiation fields. Topography also affects the Moon’s interaction with the space environment, its magnetic field, and the propagation of seismic waves. As more extensive and detailed lunar datasets become available, there is an increasing need to interpret and compare them with the results of physical models in a fully three-dimensional context. We have developed a three-dimensional framework for lunar modeling we call the Digital Moon. The goal of this work is to enable high fidelity physical modeling and visualization of the Moon in a parallel computing environment. The surface of the Moon is described by a continuous triangular mesh of arbitrary shape and spatial scale. For regions of limited geographic extent, it is convenient to employ meshes on a rectilinear grid. However for global-scale modeling, we employ a continuous geodesic gridding scheme (Teanby, 2008). Each element in the mesh surface is allowed to have a unique set of physical properties. Photon and particle interactions between mesh elements are modeled using efficient ray tracing algorithms. Heat, mass, photon and particle transfer within each mesh element are modeled in one dimension. Each compute node is assigned a portion of the mesh and collective interactions between elements are handled through network interfaces. We have used the model to calculate lunar surface and subsurface temperatures that can be compared directly with radiometric temperatures measured by the Diviner Lunar Radiometer Experiment on the Lunar Reconnaissance Orbiter. The model includes realistic surface photometric functions based on goniometric measurements of lunar soil samples (Foote and Paige, 2009), and one-dimensional thermal models based on lunar remote sensing and Apollo

  16. Modeling and simulation of complex systems a framework for efficient agent-based modeling and simulation

    CERN Document Server

    Siegfried, Robert

    2014-01-01

    Robert Siegfried presents a framework for efficient agent-based modeling and simulation of complex systems. He compares different approaches for describing structure and dynamics of agent-based models in detail. Based on this evaluation the author introduces the "General Reference Model for Agent-based Modeling and Simulation" (GRAMS). Furthermore he presents parallel and distributed simulation approaches for execution of agent-based models -from small scale to very large scale. The author shows how agent-based models may be executed by different simulation engines that utilize underlying hard

  17. Bioavailability of a new generic formulation of mycophenolate mofetil MMF 500 versus CellCept in healthy adult volunteers.

    Science.gov (United States)

    Masri, M A; Rizk, S; Attia, M L E; Barbouch, H; Rost, M

    2007-05-01

    Several studies have revealed a decreased incidence of early graft rejection with the use of mycophenate mofetil (MMF). The cost of the drug is, however, prohibitive especially in developing countries with limited resources. We compared the pharmacokinetic profile of a new MMF generic formulation (MMF 500 batch number: 06T3001; Medis Tunis) with those of Cellcept, (batch number: M1427; Hoffmann La Roche, Switzerland) in healthy volunteers. The study was double-blinded to investigator and volunteers. It had a balanced randomized, two-treatment, two-period, two-sequence, single-dose, crossover, comparative oral bioavailability design in adult healthy human volunteers. The study was designed, performed, and monitored by CRO Transmedical s.a.l International (Beirut, Lebanon) in accordance with the Basic Principals defined in the US 21 CFR Part 312.20, and the principals enunciated in the World Medical Association Declaration of Helsinki. We included nonsmoking healthy volunteers between the ages of 22 and 45 years. The subjects were admitted to the hospital one night prior to blood sampling. After volunteers received the same dinner, they were fasted overnight and for 2 hours postdosing. At 8 am each person received a single oral dose of 500 mg of either formulation. Blood samples were collected to construct the pharmacokinetic profiles as follows: 0, 0.15, 0.30, 0.45 minutes and 1, 1.15, 1.30, 2, 4, 6, 10, 12, and 24 hours. Water and food intake were the same for all volunteers during the whole study period. Following an 8-day washout period, the subjects were crossed over. Plasma mycophenolic acid concentrations were determined using a high-performance liquid chromatography validated enzyme-linked immunosorbent assay-based method (TransMedical, Beirut Lebanon). Physical examinations, hematology, urinanalysis, serum chemistry tests, and liver enzymes were performed at screening and at the end of each period. Subjects were monitored for safety and adverse events

  18. Instant e-Teaching Framework Model for Live Online Teaching

    Directory of Open Access Journals (Sweden)

    Suhailan Safei

    2011-03-01

    Full Text Available Instant e-Teaching is a new concept that supplements e-Teaching and e-Learning environment in providing a full and comprehensive modern education styles. The e-Learning technology depicts the concept of enabling self-learning among students on a certain subject using online reference and materials. While the instant e-teaching requires 'face-to-face' characteristic between teacher and student to simultaneously execute actions and gain instant responses. The word instant enhances the e-Teaching with the concept of real time teaching. The challenge to exercise online and instant teaching is not just merely relying on the technologies and system efficiency, but it needs to satisfy the usability and friendliness of the system as to replicate the traditional class environment during the deliveries of the class. For this purpose, an instant e-Teaching framework is been developed that will emulate a dedicated virtual classroom, and primarily designed for synchronous and live sharing of current teaching notes. The model has been demonstrated using a teaching Arabic recitation prototype and evaluated from the professional user profession's perspectives.

  19. A graphical model framework for decoding in the visual ERP-based BCI speller

    NARCIS (Netherlands)

    Martens, S.M.M.; Mooij, J.M.; Hill, N.J.; Farquhar, J.D.R.; Schölkopf, B.

    2011-01-01

    We present a graphical model framework for decoding in the visual ERP-based speller system. The proposed framework allows researchers to build generative models from which the decoding rules are obtained in a straightforward manner. We suggest two models for generating brain signals conditioned on

  20. Adaptive invasive species distribution models: A framework for modeling incipient invasions

    Science.gov (United States)

    Uden, Daniel R.; Allen, Craig R.; Angeler, David G.; Corral, Lucia; Fricke, Kent A.

    2015-01-01

    The utilization of species distribution model(s) (SDM) for approximating, explaining, and predicting changes in species’ geographic locations is increasingly promoted for proactive ecological management. Although frameworks for modeling non-invasive species distributions are relatively well developed, their counterparts for invasive species—which may not be at equilibrium within recipient environments and often exhibit rapid transformations—are lacking. Additionally, adaptive ecological management strategies address the causes and effects of biological invasions and other complex issues in social-ecological systems. We conducted a review of biological invasions, species distribution models, and adaptive practices in ecological management, and developed a framework for adaptive, niche-based, invasive species distribution model (iSDM) development and utilization. This iterative, 10-step framework promotes consistency and transparency in iSDM development, allows for changes in invasive drivers and filters, integrates mechanistic and correlative modeling techniques, balances the avoidance of type 1 and type 2 errors in predictions, encourages the linking of monitoring and management actions, and facilitates incremental improvements in models and management across space, time, and institutional boundaries. These improvements are useful for advancing coordinated invasive species modeling, management and monitoring from local scales to the regional, continental and global scales at which biological invasions occur and harm native ecosystems and economies, as well as for anticipating and responding to biological invasions under continuing global change.

  1. Conceptual Frameworks and Research Models on Resilience in Leadership

    Directory of Open Access Journals (Sweden)

    Janet Ledesma

    2014-08-01

    Full Text Available The purpose of this article was to discuss conceptual frameworks and research models on resilience theory. The constructs of resilience, the history of resilience theory, models of resilience, variables of resilience, career resilience, and organizational resilience will be examined and discussed as they relate to leadership development. The literature demonstrates that there is a direct relationship between the stress of the leader’s job and his or her ability to maintain resilience in the face of prolonged contact with adversity. This article discusses resilience theory as it relates to leadership development. The concept associated with resilience, which includes thriving and hardiness, is explored with the belief that resilient leaders are invaluable to the sustainability of an organization. In addition, the constructs of resilience and the history of resilience studies in the field of psychiatry, developmental psychopathy, human development, medicine, epidemiology, and the social sciences are examined. Survival, recovery, and thriving are concepts associated with resilience and describe the stage at which a person may be during or after facing adversity. The concept of “thriving” refers to a person’s ability to go beyond his or her original level of functioning and to grow and function despite repeated exposure to stressful experiences. The literature suggests a number of variables that characterize resilience and thriving. These variables include positive self-esteem, hardiness, strong coping skills, a sense of coherence, self-efficacy, optimism, strong social resources, adaptability, risk-taking, low fear of failure, determination, perseverance, and a high tolerance of uncertainty. These are reviewed in this article. The findings in this article suggest that those who develop leaders need to create safe environments to help emerging and existing leaders thrive as individuals and as organizational leaders in the area of resilience

  2. D Geological Framework Models as a Teaching Aid for Geoscience

    Science.gov (United States)

    Kessler, H.; Ward, E.; Geological ModelsTeaching Project Team

    2010-12-01

    3D geological models have great potential as a resource for universities when teaching foundation geological concepts as it allows the student to visualise and interrogate UK geology. They are especially useful when dealing with the conversion of 2D field, map and GIS outputs into three dimensional geological units, which is a common problem for all students of geology. Today’s earth science students use a variety of skills and processes during their learning experience including the application of schema’s, spatial thinking, image construction, detecting patterns, memorising figures, mental manipulation and interpretation, making predictions and deducing the orientation of themselves and the rocks. 3D geological models can reinforce spatial thinking strategies and encourage students to think about processes and properties, in turn helping the student to recognise pre-learnt geological principles in the field and to convert what they see at the surface into a picture of what is going on at depth. Learning issues faced by students may also be encountered by experts, policy managers, and stakeholders when dealing with environmental problems. Therefore educational research of student learning in earth science may also improve environmental decision making. 3D geological framework models enhance the learning of Geosciences because they: ● enable a student to observe, manipulate and interpret geology; in particular the models instantly convert two-dimensional geology (maps, boreholes and cross-sections) into three dimensions which is a notoriously difficult geospatial skill to acquire. ● can be orientated to whatever the user finds comfortable and most aids recognition and interpretation. ● can be used either to teach geosciences to complete beginners or add to experienced students body of knowledge (whatever point that may be at). Models could therefore be packaged as a complete educational journey or students and tutor can select certain areas of the model

  3. Airline Sustainability Modeling: A New Framework with Application of Bayesian Structural Equation Modeling

    Directory of Open Access Journals (Sweden)

    Hashem Salarzadeh Jenatabadi

    2016-11-01

    Full Text Available There are many factors which could influence the sustainability of airlines. The main purpose of this study is to introduce a framework for a financial sustainability index and model it based on structural equation modeling (SEM with maximum likelihood and Bayesian predictors. The introduced framework includes economic performance, operational performance, cost performance, and financial performance. Based on both Bayesian SEM (Bayesian-SEM and Classical SEM (Classical-SEM, it was found that economic performance with both operational performance and cost performance are significantly related to the financial performance index. The four mathematical indices employed are root mean square error, coefficient of determination, mean absolute error, and mean absolute percentage error to compare the efficiency of Bayesian-SEM and Classical-SEM in predicting the airline financial performance. The outputs confirmed that the framework with Bayesian prediction delivered a good fit with the data, although the framework predicted with a Classical-SEM approach did not prepare a well-fitting model. The reasons for this discrepancy between Classical and Bayesian predictions, as well as the potential advantages and caveats with the application of Bayesian approach in airline sustainability studies, are debated.

  4. Legitimising neural network river forecasting models: a new data-driven mechanistic modelling framework

    Science.gov (United States)

    Mount, N. J.; Dawson, C. W.; Abrahart, R. J.

    2013-01-01

    In this paper we address the difficult problem of gaining an internal, mechanistic understanding of a neural network river forecasting (NNRF) model. Neural network models in hydrology have long been criticised for their black-box character, which prohibits adequate understanding of their modelling mechanisms and has limited their broad acceptance by hydrologists. In response, we here present a new, data-driven mechanistic modelling (DDMM) framework that incorporates an evaluation of the legitimacy of a neural network's internal modelling mechanism as a core element in the model development process. The framework is exemplified for two NNRF modelling scenarios, and uses a novel adaptation of first order, partial derivate, relative sensitivity analysis methods as the means by which each model's mechanistic legitimacy is explored. The results demonstrate the limitations of standard, goodness-of-fit validation procedures applied by NNRF modellers, by highlighting how the internal mechanisms of complex models that produce the best fit scores can have much lower legitimacy than simpler counterparts whose scores are only slightly inferior. The study emphasises the urgent need for better mechanistic understanding of neural network-based hydrological models and the further development of methods for elucidating their mechanisms.

  5. Neuromagnetic mismatch field (MMF) dependence on the auditory temporal integration window and the existence of categorical boundaries: comparisons between dissyllabic words and their equivalent tones.

    Science.gov (United States)

    Inouchi, Mayako; Kubota, Mikio; Ohta, Katsuya; Matsushima, Eisuke; Ferrari, Paul; Scovel, Thomas

    2008-09-26

    Previous duration-related auditory mismatch response studies have tested vowels, words, and tones. Recently, the elicitation of strong neuromagnetic mismatch field (MMF) components in response to large (>32%) vowel-duration decrements was clearly observed within dissyllabic words. To date, however, the issues of whether this MMF duration-decrement effect also extends to duration increments, and to what degree these duration decrements and increments are attributed to their corresponding non-speech acoustic properties remainto be resolved. Accordingly, this magnetoencephalographic (MEG) study investigated whether prominent MMF components would be evoked by both duration decrements and increments for dissyllabic word stimuli as well as frequency-band matched tones in order to corroborate the relation between the MMF elicitation and the directions of duration changes in speech and non-speech. Further, the peak latency effectsdepending on stimulus types (words vs. tones) were examined. MEG responses were recorded with a whole-head 148-channel magnetometer, while subjects passively listened to the stimuli presented within an odd-ball paradigm for both shortened duration (180-->100%) and lengthened duration (100-->180%). Prominent MMF components were observed in the shortened and lengthened paradigms for the word stimuli, but only in the shortened paradigm for tones. The MMF peak latency results showed that the words ledtoearlier peak latencies than the tones. These findings suggest that duration lengthening as well as shortening in words produces a salient acoustic MMF response when the divergent point between the long and short durations fallswithin the temporal window ofauditory integration post sound onset (<200 ms), and that theearlier latency of the dissyllabic word stimuli over tones is due to a prominent syllable structure in words which is used to generate temporal categorical boundaries.

  6. Designing a framework to design a business model for the 'bottom of the pyramid' population

    NARCIS (Netherlands)

    Ver loren van Themaat, Tanye; Schutte, Cornelius S.L.; Lutters, Diederick

    2013-01-01

    This article presents a framework for developing and designing a business model to target the bottom of the pyramid (BoP) population. Using blue ocean strategy and business model literature, integrated with research on the BoP, the framework offers a systematic approach for organisations to analyse

  7. Designing a framework to design a business model for the 'bottom of the pyramid' population

    NARCIS (Netherlands)

    Ver loren van Themaat, Tanye; Schutte, Cornelius S.L.; Lutters, Eric

    2013-01-01

    This article presents a framework for developing and designing a business model to target the bottom of the pyramid (BoP) population. Using blue ocean strategy and business model literature, integrated with research on the BoP, the framework offers a systematic approach for organisations to analyse

  8. A modeling framework for the evolution and spread of antibiotic resistance: literature review and model categorization.

    Science.gov (United States)

    Spicknall, Ian H; Foxman, Betsy; Marrs, Carl F; Eisenberg, Joseph N S

    2013-08-15

    Antibiotic-resistant infections complicate treatment and increase morbidity and mortality. Mathematical modeling has played an integral role in improving our understanding of antibiotic resistance. In these models, parameter sensitivity is often assessed, while model structure sensitivity is not. To examine the implications of this, we first reviewed the literature on antibiotic-resistance modeling published between 1993 and 2011. We then classified each article's model structure into one or more of 6 categories based on the assumptions made in those articles regarding within-host and population-level competition between antibiotic-sensitive and antibiotic-resistant strains. Each model category has different dynamic implications with respect to how antibiotic use affects resistance prevalence, and therefore each may produce different conclusions about optimal treatment protocols that minimize resistance. Thus, even if all parameter values are correctly estimated, inferences may be incorrect because of the incorrect selection of model structure. Our framework provides insight into model selection.

  9. A Framework Model for an Order Fulfillment System Based on Service Oriented Architecture

    Institute of Scientific and Technical Information of China (English)

    YANG Li-xi; LI Shi-qi

    2008-01-01

    To effectively implement order fulfillment, we present an integrated framework model focusing on the whole process of order fulfillment. Firstly, five aims of the OFS (order fulfillment system) are built. Then after discussing three major processes of order fulfillment, we summarize functional and quality attributes of the OFS. Subsequently, we investigate SOA (Service Oriented Architecture) and present a SOA meta-model to be an integrated framework and to fulfill quality requirements. Moreover, based on the SOA meta-model, we construct a conceptual framework model that aims to conveniently integrate other functions from different systems into the order fulfillment system. This model offers enterprises a new approach to implementing order fulfillment.

  10. Combined use of MMF with low dosage of cyclosporine A in renal transplantation%骁悉与小剂量环孢素A在尸体肾移植中的联合应用

    Institute of Scientific and Technical Information of China (English)

    凌建煜; 祝宇; 孙福康

    1998-01-01

    In order to compare the therapeutics of combined use of MMF with low dose of cyclosporine A (CsA) in renal transplantation, 16 cases were randomly divided into 3 groups:MMF 2.0g group receiving MMF 2.0g per day, MMF 1.5g group receiving MMF 1.5g per day,and Aza group. All the patients in the 3 groups were given the low dosage of CsA and steroid.The results showed that no patients in MMF 2.0g group experienced acute rejection. One patient (20%) in MMF 1.5g group occurred twice acute rejections. In Aza group 3 out of 5 patients (60%) experienced acute rejections. Six months after transplantation, serum Cr level and the used dose of CsA in MMF 2.0g group was obviously lower than that of Aza group. It was concluded that the combined use of 2.0g MMF per day with low dosage of CsA and steroid was safe and efficacy for renal transplanted patients. The clinical results of MMF 2.0g group were superior to those of Aza group.%为观察骁悉(MMF)与小剂量环孢素A(CsA)联合应用于尸体肾移植中的效果,将16例患者随机分为3组,MMF 2.0g组(MMF用量为2.0g/d);MMF 1.5g组(MMF用量为1.5g/d);硫唑嘌呤(Aza)组.3组患者均同时接受相似剂量的CsA和类固醇治疗.结果 MMF 2.0g组未发生急性排斥;MMF 1.5g组1例(1/5)患者先后发生2次排斥;Aza组3例(3/5)患者各发生1次排斥.术后6个月MMF 2.0g组患者血清肌酐值明显低于Aza组,其所用的CsA剂量低于Aza组.认为MMF无明显肝、肾毒性,每天2.0g口服,并与小剂量CsA和类固醇联合应用,临床疗效明显优于传统的三联疗法.

  11. Model-Based Reasoning in the Upper-Division Physics Laboratory: Framework and Initial Results

    CERN Document Server

    Zwickl, Benjamin M; Finkelstein, Noah; Lewandowski, H J

    2014-01-01

    Constructing and using models are core scientific practices that have gained significant attention within K-12 and higher education. Although modeling is a broadly applicable process, within physics education, it has been preferentially applied to the iterative development of broadly applicable principles (e.g., Newton's laws of motion in introductory mechanics). We review and extend existing frameworks on modeling to develop a new framework that more naturally describes model-based reasoning in upper-division physics labs. A significant feature of the new framework is that measurement tools (in addition to the physical system being studied) are subjected to the process of modeling. Think-aloud interviews were used to document examples of model-based reasoning in the laboratory and refine the modeling framework. The interviews showed how students productively applied similar facets of modeling to the physical system and measurement tools: construction, prediction, interpretation of data, identification of mod...

  12. Computer-aided modeling framework for efficient model development, analysis and identification

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Sales Cruz, Mauricio;

    2011-01-01

    branches; the first branch deals with single-scale model development while the second branch introduces features for multiscale model development to the methodology. In this paper, the emphasis is on single-scale model development and application part. The modeling framework and the supported stepwise......Model-based computer aided product-process engineering has attained increased importance in a number of industries, including pharmaceuticals, petrochemicals, fine chemicals, polymers, biotechnology, food, energy, and water. This trend is set to continue due to the substantial benefits computer......-aided methods introduce. The key prerequisite of computer-aided product-process engineering is however the availability of models of different types, forms, and application modes. The development of the models required for the systems under investigation tends to be a challenging and time-consuming task...

  13. Toward unification of the multiscale modeling of the atmosphere

    Directory of Open Access Journals (Sweden)

    A. Arakawa

    2011-01-01

    Full Text Available This paper suggests two possible routes to achieve the unification of model physics in coarse- and fine-resolution atmospheric models. As far as representation of deep moist convection is concerned, only two kinds of model physics are used at present: highly parameterized as in the conventional general circulation models (GCMs and explicitly simulated as in the cloud-resolving models (CRMs. Ideally, these two kinds of model physics should be unified so that a continuous transition of model physics from one kind to the other takes place as the resolution changes. With such unification, the GCM can converge to a global CRM (GCRM as the grid size is refined. ROUTE I for unification continues to follow the parameterization approach, but uses a unified parameterization that is applicable to any horizontal resolutions between those typically used by GCMs and CRMs. It is shown that a key to construct such a unified parameterization is to eliminate the assumption of small fractional area covered by convective clouds, which is commonly used in the conventional cumulus parameterizations either explicitly or implicitly. A preliminary design of the unified parameterization is presented, which demonstrates that such an assumption can be eliminated through a relatively minor modification of the existing mass-flux based parameterizations. Partial evaluations of the unified parameterization are also presented. ROUTE II for unification follows the "multi-scale modeling framework (MMF" approach, which takes advantage of explicit representation of deep moist convection and associated cloud-scale processes by CRMs. The Quasi-3-D (Q3-D MMF is an attempt to broaden the applicability of MMF without necessarily using a fully three-dimensional CRM. This is accomplished using a network of cloud-resolving grids with gaps. An outline of the Q3-D algorithm and highlights of preliminary results are reviewed.

  14. A unified framework for modeling landscape evolution by discrete flows

    Science.gov (United States)

    Shelef, Eitan; Hilley, George E.

    2016-05-01

    Topographic features such as branched valley networks and undissected convex-up hillslopes are observed in disparate physical environments. In some cases, these features are formed by sediment transport processes that occur discretely in space and time, while in others, by transport processes that are uniformly distributed across the landscape. This paper presents an analytical framework that reconciles the basic attributes of such sediment transport processes with the topographic features that they form and casts those in terms that are likely common to different physical environments. In this framework, temporal changes in surface elevation reflect the frequency with which the landscape is traversed by geophysical flows generated discretely in time and space. This frequency depends on the distance to which flows travel downslope, which depends on the dynamics of individual flows, the lithologic and topographic properties of the underlying substrate, and the coevolution of topography, erosion, and the routing of flows over the topographic surface. To explore this framework, we postulate simple formulations for sediment transport and flow runout distance and demonstrate that the conditions for hillslope and channel network formation can be cast in terms of fundamental parameters such as distance from drainage divide and a friction-like coefficient that describes a flow's resistance to motion. The framework we propose is intentionally general, but the postulated formulas can be substituted with those that aim to describe a specific process and to capture variations in the size distribution of such flow events.

  15. Framework for Modelling Multiple Input Complex Aggregations for Interactive Installations

    DEFF Research Database (Denmark)

    Padfield, Nicolas; Andreasen, Troels

    2012-01-01

    We describe a generalized framework as a method and design tool for creating interactive installations with a demand for exploratory meaning creation, not limited to the design stage, but extending into the stage where the installation meets participants and audience. The proposed solution is bas...

  16. Parametric design and analysis framework with integrated dynamic models

    DEFF Research Database (Denmark)

    Negendahl, Kristoffer

    2014-01-01

    of building energy and indoor environment, are generally confined to late in the design process. Consequence based design is a framework intended for the early design stage. It involves interdisciplinary expertise that secures validity and quality assurance with a simulationist while sustaining autonomous...

  17. Holland's RIASEC Model as an Integrative Framework for Individual Differences

    Science.gov (United States)

    Armstrong, Patrick Ian; Day, Susan X.; McVay, Jason P.; Rounds, James

    2008-01-01

    Using data from published sources, the authors investigated J. L. Holland's (1959, 1997) theory of interest types as an integrative framework for organizing individual differences variables that are used in counseling psychology. Holland's interest types were used to specify 2- and 3-dimensional interest structures. In Study 1, measures of…

  18. Holland's RIASEC Model as an Integrative Framework for Individual Differences

    Science.gov (United States)

    Armstrong, Patrick Ian; Day, Susan X.; McVay, Jason P.; Rounds, James

    2008-01-01

    Using data from published sources, the authors investigated J. L. Holland's (1959, 1997) theory of interest types as an integrative framework for organizing individual differences variables that are used in counseling psychology. Holland's interest types were used to specify 2- and 3-dimensional interest structures. In Study 1, measures of…

  19. Total Quality Management (TQM framework for e-learning based on EFQM and Kirkpatrick models

    Directory of Open Access Journals (Sweden)

    Jeanne Schreurs

    2006-07-01

    Full Text Available The EFQM excellence model is a famous quality management tool. We have translated it to be useful in e-learning quality management. EFQM will be used as a framework for self-evaluation. We developed the e-learning stakeholder model. We identified the main criterion and positioned them in the stakeholder model. We present short the Kirkpatrick evaluation model of e-learning. We developed a Kirkpatrick-EFQM self-assessment framework. We propose the limited learner-centric self-assessment framework. A preliminary set of quality criteria have been identified for self-assessment by the learners.

  20. Software Process Improvement Framework Based on CMMI Continuous Model Using QFD

    Directory of Open Access Journals (Sweden)

    Yonghui Cao

    2013-01-01

    Full Text Available In the rapid technological innovation and changes era, the key to the survival company is the continuous improvement of its process. In this paper, we introduce Software Process Improvement (SPI and Quality Function Deployment (QFD; and for combining also the staged model and the continuous model in CMMI, the Software Process Improvement framework with CMMI has two parts: 1 Software Process Improvement framework with CMMI staged model based on QFD and 2 SPI framework for C MI Mbased on QFD continuous model. Finally, we also draw conclusions.

  1. From Principles to Details: Integrated Framework for Architecture Modelling of Large Scale Software Systems

    Directory of Open Access Journals (Sweden)

    Andrzej Zalewski

    2013-06-01

    Full Text Available There exist numerous models of software architecture (box models, ADL’s, UML, architectural decisions, architecture modelling frameworks (views, enterprise architecture frameworks and even standards recommending practice for the architectural description. We show in this paper, that there is still a gap between these rather abstract frameworks/standards and existing architecture models. Frameworks and standards define what should be modelled rather than which models should be used and how these models are related to each other. We intend to prove that a less abstract modelling framework is needed for the effective modelling of large scale software intensive systems. It should provide a more precise guidance kinds of models to be employed and how they should relate to each other. The paper defines principles that can serve as base for an integrated model. Finally, structure of such a model has been proposed. It comprises three layers: the upper one – architectural policy – reflects corporate policy and strategies in architectural terms, the middle one –system organisation pattern – represents the core structural concepts and their rationale at a given level of scope, the lower one contains detailed architecture models. Architectural decisions play an important role here: they model the core architectural concepts explaining detailed models as well as organise the entire integrated model and the relations between its submodels.

  2. System modeling with the DISC framework: evidence from safety-critical domains.

    Science.gov (United States)

    Reiman, Teemu; Pietikäinen, Elina; Oedewald, Pia; Gotcheva, Nadezhda

    2012-01-01

    The objective of this paper is to illustrate the development and application of the Design for Integrated Safety Culture (DISC) framework for system modeling by evaluating organizational potential for safety in nuclear and healthcare domains. The DISC framework includes criteria for good safety culture and a description of functions that the organization needs to implement in order to orient the organization toward the criteria. Three case studies will be used to illustrate the utilization of the DISC framework in practice.

  3. Experimental development based on mapping rule between requirements analysis model and web framework specific design model.

    Science.gov (United States)

    Okuda, Hirotaka; Ogata, Shinpei; Matsuura, Saeko

    2013-12-01

    Model Driven Development is a promising approach to develop high quality software systems. We have proposed a method of model-driven requirements analysis using Unified Modeling Language (UML). The main feature of our method is to automatically generate a Web user interface prototype from UML requirements analysis model so that we can confirm validity of input/output data for each page and page transition on the system by directly operating the prototype. We proposes a mapping rule in which design information independent of each web application framework implementation is defined based on the requirements analysis model, so as to improve the traceability to the final product from the valid requirements analysis model. This paper discusses the result of applying our method to the development of a Group Work Support System that is currently running in our department.

  4. Modelling plasticity of unsaturated soils in a thermodynamically consistent framework

    CERN Document Server

    Coussy, O

    2010-01-01

    Constitutive equations of unsaturated soils are often derived in a thermodynamically consistent framework through the use a unique 'effective' interstitial pressure. This later is naturally chosen as the space averaged interstitial pressure. However, experimental observations have revealed that two stress state variables were needed to describe the stress-strain-strength behaviour of unsaturated soils. The thermodynamics analysis presented here shows that the most general approach to the behaviour of unsaturated soils actually requires three stress state variables: the suction, which is required to describe the retention properties of the soil and two effective stresses, which are required to describe the soil deformation at water saturation held constant. Actually, it is shown that a simple assumption related to internal deformation leads to the need of a unique effective stress to formulate the stress-strain constitutive equation describing the soil deformation. An elastoplastic framework is then presented ...

  5. A Framework for Modeling and Simulation of the Artificial

    Science.gov (United States)

    2012-01-01

    valid OMB control number. 1. REPORT DATE 2012 2. REPORT TYPE 3. DATES COVERED 00-00-2012 to 00-00-2012 4. TITLE AND SUBTITLE A Framework for...style of symphonic, folk, or jazz . A musical performance can also therefore have an ensemble of orches- tra, small group, or soloist. With no...constraint m3 :musical-performance (==> (equale (e@ style) jazz ) (or (equale (e@ ensemble) small-group) (equale (e@ ensemble) orchestra)))) (orv (ifv

  6. A Modular Simulation Framework for Assessing Swarm Search Models

    Science.gov (United States)

    2014-09-01

    Simulink . American Institute of Aeronautics and Astronautics, 2011. [31] MathWorks. (2014, Jun. 25). Strategies for efficient use of memory - MATLAB ... Simulink . [Online]. Available: http://www.mathworks.com/help/ matlab / matlab \\ _prog/strategies-for-efficient-use-of-memory.html [32] J. P. C. Kleijnen, S. M...explored utilizing today’s search decision support and analysis tools. This thesis develops a framework in MATLAB that allows the investigation of search

  7. Advances in Geoscience Modeling: Smart Modeling Frameworks, Self-Describing Models and the Role of Standardized Metadata

    Science.gov (United States)

    Peckham, Scott

    2016-04-01

    Over the last decade, model coupling frameworks like CSDMS (Community Surface Dynamics Modeling System) and ESMF (Earth System Modeling Framework) have developed mechanisms that make it much easier for modelers to connect heterogeneous sets of process models in a plug-and-play manner to create composite "system models". These mechanisms greatly simplify code reuse, but must simultaneously satisfy many different design criteria. They must be able to mediate or compensate for differences between the process models, such as their different programming languages, computational grids, time-stepping schemes, variable names and variable units. However, they must achieve this interoperability in a way that: (1) is noninvasive, requiring only relatively small and isolated changes to the original source code, (2) does not significantly reduce performance, (3) is not time-consuming or confusing for a model developer to implement, (4) can very easily be updated to accommodate new versions of a given process model and (5) does not shift the burden of providing model interoperability to the model developers. In tackling these design challenges, model framework developers have learned that the best solution is to provide each model with a simple, standardized interface, i.e. a set of standardized functions that make the model: (1) fully-controllable by a caller (e.g. a model framework) and (2) self-describing with standardized metadata. Model control functions are separate functions that allow a caller to initialize the model, advance the model's state variables in time and finalize the model. Model description functions allow a caller to retrieve detailed information on the model's input and output variables, its computational grid and its timestepping scheme. If the caller is a modeling framework, it can use the self description functions to learn about each process model in a collection to be coupled and then automatically call framework service components (e.g. regridders

  8. A PLM components monitoring framework for SMEs based on a PLM maturity model and FAHP methodology

    OpenAIRE

    Zhang, Haiqing; Sekhari, Aicha; Ouzrout, Yacine; Bouras, Abdelaziz

    2014-01-01

    Right PLM components selection and investments increase business advantages. This paper develops a PLM components monitoring framework to assess and guide PLM implementation in small and middle enterprises (SMEs). The framework builds upon PLM maturity models and decision-making methodology. PLM maturity model has the capability to analyze PLM functionalities and evaluate PLM components. A proposed PLM components maturity assessment (PCMA) model can obtain general maturity levels of PLM compo...

  9. Toward unification of the multiscale modeling of the atmosphere

    Directory of Open Access Journals (Sweden)

    A. Arakawa

    2011-04-01

    Full Text Available As far as the representation of deep moist convection is concerned, only two kinds of model physics are used at present: highly parameterized as in the conventional general circulation models (GCMs and explicitly simulated as in the cloud-resolving models (CRMs. Ideally, these two kinds of model physics should be unified so that a continuous transition of model physics from one kind to the other takes place as the resolution changes. With such unification, the GCM can converge to a global CRM (GCRM as the grid size is refined. This paper suggests two possible routes to achieve the unification. ROUTE I continues to follow the parameterization approach, but uses a unified parameterization that is applicable to any horizontal resolutions between those typically used by GCMs and CRMs. It is shown that a key to construct such a unified parameterization is to eliminate the assumption of small fractional area covered by convective clouds, which is commonly used in the conventional cumulus parameterizations either explicitly or implicitly. A preliminary design of the unified parameterization is presented, which demonstrates that such an assumption can be eliminated through a relatively minor modification of the existing mass-flux based parameterizations. Partial evaluations of the unified parameterization are also presented. ROUTE II follows the "multi-scale modeling framework (MMF" approach, which takes advantage of explicit representation of deep moist convection and associated cloud-scale processes by CRMs. The Quasi-3-D (Q3-D MMF is an attempt to broaden the applicability of MMF without necessarily using a fully three-dimensional CRM. This is accomplished using a network of cloud-resolving grids with large gaps. An outline of the Q3-D algorithm and highlights of preliminary results are reviewed.

  10. Assessing Students' Understandings of Biological Models and Their Use in Science to Evaluate a Theoretical Framework

    Science.gov (United States)

    Grünkorn, Juliane; Upmeier zu Belzen, Annette; Krüger, Dirk

    2014-01-01

    Research in the field of students' understandings of models and their use in science describes different frameworks concerning these understandings. Currently, there is no conjoint framework that combines these structures and so far, no investigation has focused on whether it reflects students' understandings sufficiently (empirical evaluation).…

  11. Applying the Nominal Response Model within a Longitudinal Framework to Construct the Positive Family Relationships Scale

    Science.gov (United States)

    Preston, Kathleen Suzanne Johnson; Parral, Skye N.; Gottfried, Allen W.; Oliver, Pamella H.; Gottfried, Adele Eskeles; Ibrahim, Sirena M.; Delany, Danielle

    2015-01-01

    A psychometric analysis was conducted using the nominal response model under the item response theory framework to construct the Positive Family Relationships scale. Using data from the Fullerton Longitudinal Study, this scale was constructed within a long-term longitudinal framework spanning middle childhood through adolescence. Items tapping…

  12. Robustness Analysis of Road Networks: a Framework with Combined DTA Models

    NARCIS (Netherlands)

    Li, M.

    2008-01-01

    Network robustness is the ability of a road network functioning properly facing unpredictable and exceptional incidents. A systematical framework with combined dynamic traffic assignment (DTA) models is designed for the analysis of road network robustness. With this framework, network performance co

  13. A model based safety architecture framework for Dutch high speed train lines

    NARCIS (Netherlands)

    Schuitemaker, K.; Braakhuis, J.G.; Rajabalinejad, M.

    2015-01-01

    This paper presents a model-based safety architecture framework (MBSAF) for capturing and sharing architectural knowledge of safety cases of safetycritical systems of systems (SoS). Whilst architecture frameworks in the systems engineering domain consider safety often as dependent attribute, this st

  14. Towards a Framework for Modelling and Verification of Relay Interlocking Systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2010-01-01

    This paper describes a framework currently under development for modelling, simulation, and verification of relay interlocking systems as used by the Danish railways. The framework is centred around a domain-specific language (DSL) for describing such systems, and provides (1) a graphical editor ...

  15. Integration of the DAYCENT Biogeochemical Model within a Multi-Model Framework

    Energy Technology Data Exchange (ETDEWEB)

    David Muth

    2012-07-01

    Agricultural residues are the largest near term source of cellulosic 13 biomass for bioenergy production, but removing agricultural residues sustainably 14 requires considering the critical roles that residues play in the agronomic system. 15 Determining sustainable removal rates for agricultural residues has received 16 significant attention and integrated modeling strategies have been built to evaluate 17 sustainable removal rates considering soil erosion and organic matter constraints. 18 However the current integrated model does not quantitatively assess soil carbon 19 and long term crop yields impacts of residue removal. Furthermore the current 20 integrated model does not evaluate the greenhouse gas impacts of residue 21 removal, specifically N2O and CO2 gas fluxes from the soil surface. The DAYCENT 22 model simulates several important processes for determining agroecosystem 23 performance. These processes include daily Nitrogen-gas flux, daily carbon dioxide 24 flux from soil respiration, soil organic carbon and nitrogen, net primary productivity, 25 and daily water and nitrate leaching. Each of these processes is an indicator of 26 sustainability when evaluating emerging cellulosic biomass production systems for 27 bioenergy. A potentially vulnerable cellulosic biomass resource is agricultural 28 residues. This paper presents the integration of the DAYCENT model with the 29 existing integration framework modeling tool to investigate additional environment 30 impacts of agricultural residue removal. The integrated model is extended to 31 facilitate two-way coupling between DAYCENT and the existing framework. The 32 extended integrated model is applied to investigate additional environmental 33 impacts from a recent sustainable agricultural residue removal dataset. The 34 integrated model with DAYCENT finds some differences in sustainable removal 35 rates compared to previous results for a case study county in Iowa. The extended 36 integrated model with

  16. EarthCube - Earth System Bridge: Spanning Scientific Communities with Interoperable Modeling Frameworks

    Science.gov (United States)

    Peckham, S. D.; DeLuca, C.; Gochis, D. J.; Arrigo, J.; Kelbert, A.; Choi, E.; Dunlap, R.

    2014-12-01

    In order to better understand and predict environmental hazards of weather/climate, ecology and deep earth processes, geoscientists develop and use physics-based computational models. These models are used widely both in academic and federal communities. Because of the large effort required to develop and test models, there is widespread interest in component-based modeling, which promotes model reuse and simplified coupling to tackle problems that often cross discipline boundaries. In component-based modeling, the goal is to make relatively small changes to models that make it easy to reuse them as "plug-and-play" components. Sophisticated modeling frameworks exist to rapidly couple these components to create new composite models. They allow component models to exchange variables while accommodating different programming languages, computational grids, time-stepping schemes, variable names and units. Modeling frameworks have arisen in many modeling communities. CSDMS (Community Surface Dynamics Modeling System) serves the academic earth surface process dynamics community, while ESMF (Earth System Modeling Framework) serves many federal Earth system modeling projects. Others exist in both the academic and federal domains and each satisfies design criteria that are determined by the community they serve. While they may use different interface standards or semantic mediation strategies, they share fundamental similarities. The purpose of the Earth System Bridge project is to develop mechanisms for interoperability between modeling frameworks, such as the ability to share a model or service component. This project has three main goals: (1) Develop a Framework Description Language (ES-FDL) that allows modeling frameworks to be described in a standard way so that their differences and similarities can be assessed. (2) Demonstrate that if a model is augmented with a framework-agnostic Basic Model Interface (BMI), then simple, universal adapters can go from BMI to a

  17. Lack of benefit of early protocol biopsies in renal transplant patients receiving TAC and MMF: a randomized study.

    Science.gov (United States)

    Rush, D; Arlen, D; Boucher, A; Busque, S; Cockfield, S M; Girardin, C; Knoll, G; Lachance, J-G; Landsberg, D; Shapiro, J; Shoker, A; Yilmaz, S

    2007-11-01

    We conducted a randomized, multicenter study to determine whether treatment of subclinical rejection with increased corticosteroids resulted in beneficial outcomes in renal transplant patients receiving tacrolimus (TAC), mycophenolate mofetil (MMF) and prednisone. One hundred and twenty-one patients were randomized to biopsies at 0,1,2,3 and 6 months (Biopsy arm), and 119 to biopsies at 0 and 6 months only (Control arm). The primary endpoint of the study was the prevalence of the sum of the interstitial and tubular scores (ci + ct)> 2 (Banff) at 6 months. Secondary endpoints included clinical and subclinical rejection and renal function. At 6 months, 34.8% of the Biopsy and 20.5% of the Control arm patients had a ci + ct score >or= 2 (p = 0.07). Between months 0 and 6, clinical rejection episodes were 12 in 10 Biopsy arm patients and 8 in 8 Control arm patients (p = 0.44). Overall prevalence of subclinical rejection in the Biopsy arm was 4.6%. Creatinine clearance at 6 months was 72.9 +/- 21.7 in the Biopsy and 68.90 mL/min +/- 18.35 mL/min in the Control arm patients (p = 0.18). In conclusion, we found no benefit to the procurement of early protocol biopsies in renal transplant patients receiving TAC, MMF and prednisone, at least in the short term. This is likely due to their low prevalence of subclinical rejection.

  18. Temporo-spatial model construction using the MML and software framework.

    Science.gov (United States)

    Chang, David C; Dokos, Socrates; Lovell, Nigel H

    2011-12-01

    Development of complex temporo-spatial biological computational models can be a time consuming and arduous task. These models may contain hundreds of differential equations as well as realistic geometries that may require considerable investment in time to ensure that all model components are correctly implemented and error free. To tackle this problem, the Modeling Markup Languages (MML) and software framework is a modular XML/HDF5-based specification and toolkits that aims to simplify this process. The main goal of this framework is to encourage reusability, sharing and storage. To achieve this, the MML framework utilizes the CellML specification and repository, which comprises an extensive range of curated models available for use. The MML framework is an open-source project available at http://mml.gsbme.unsw.edu.au.

  19. A general mathematical framework for representing soil organic matter dynamics in biogeochemistry models

    Science.gov (United States)

    Sierra, C. A.; Mueller, M.

    2013-12-01

    Recent work have highlighted the importance of nonlinear interactions in representing the decomposition of soil organic matter (SOM). It is unclear however how to integrate these concepts into larger biogeochemical models or into a more general mathematical description of the decomposition process. Here we present a mathematical framework that generalizes both previous decomposition models and recent ideas about nonlinear microbial interactions. The framework is based on a set of four basic principles: 1) mass balance, 2) heterogeneity in the decomposability of SOM, 3) transformations in the decomposability of SOM over time, 4) energy limitation of decomposers. This framework generalizes a large majority of SOM decomposition models proposed to date. We illustrate the application of this framework to the development of a continuous model that includes the ideas in the Dual Arrhenius Michaelis-Menten Model (DAMM) for explicitly representing temperature-moisture limitations of enzyme activity in the decomposition of heterogenous substrates.

  20. Model-based reasoning in the physics laboratory: Framework and initial results

    Science.gov (United States)

    Zwickl, Benjamin M.; Hu, Dehui; Finkelstein, Noah; Lewandowski, H. J.

    2015-12-01

    [This paper is part of the Focused Collection on Upper Division Physics Courses.] We review and extend existing frameworks on modeling to develop a new framework that describes model-based reasoning in introductory and upper-division physics laboratories. Constructing and using models are core scientific practices that have gained significant attention within K-12 and higher education. Although modeling is a broadly applicable process, within physics education, it has been preferentially applied to the iterative development of broadly applicable principles (e.g., Newton's laws of motion in introductory mechanics). A significant feature of the new framework is that measurement tools (in addition to the physical system being studied) are subjected to the process of modeling. Think-aloud interviews were used to refine the framework and demonstrate its utility by documenting examples of model-based reasoning in the laboratory. When applied to the think-aloud interviews, the framework captures and differentiates students' model-based reasoning and helps identify areas of future research. The interviews showed how students productively applied similar facets of modeling to the physical system and measurement tools: construction, prediction, interpretation of data, identification of model limitations, and revision. Finally, we document students' challenges in explicitly articulating assumptions when constructing models of experimental systems and further challenges in model construction due to students' insufficient prior conceptual understanding. A modeling perspective reframes many of the seemingly arbitrary technical details of measurement tools and apparatus as an opportunity for authentic and engaging scientific sense making.

  1. The Framework Dedicated to Three Phase Flows Wellbore Modelling

    Directory of Open Access Journals (Sweden)

    Bartlomiej Bielecki

    2015-01-01

    Full Text Available To predict physical properties in a wellbore during oil and gas production, scientists use empirical correlations or mechanistic approach algorithms. The typical research in this field is concentrated on a single property analysis as heat transfer, pressure, temperature, and so forth. Here the most proper correlations, regarding the subject, are presented. And the authors studied how to join all correlations into the full framework which returns all production parameters at every depth in a wellbore. Additionally, the presented simulation results are studied here. Based on presented algorithms, the proper tool has been applied and the results shown in this paper are taken from this application.

  2. Model-based visual tracking the OpenTL framework

    CERN Document Server

    Panin, Giorgio

    2011-01-01

    This book has two main goals: to provide a unifed and structured overview of this growing field, as well as to propose a corresponding software framework, the OpenTL library, developed by the author and his working group at TUM-Informatik. The main objective of this work is to show, how most real-world application scenarios can be naturally cast into a common description vocabulary, and therefore implemented and tested in a fully modular and scalable way, through the defnition of a layered, object-oriented software architecture.The resulting architecture covers in a seamless way all processin

  3. A model independent S/W framework for search-based software testing.

    Science.gov (United States)

    Oh, Jungsup; Baik, Jongmoon; Lim, Sung-Hwa

    2014-01-01

    In Model-Based Testing (MBT) area, Search-Based Software Testing (SBST) has been employed to generate test cases from the model of a system under test. However, many types of models have been used in MBT. If the type of a model has changed from one to another, all functions of a search technique must be reimplemented because the types of models are different even if the same search technique has been applied. It requires too much time and effort to implement the same algorithm over and over again. We propose a model-independent software framework for SBST, which can reduce redundant works. The framework provides a reusable common software platform to reduce time and effort. The software framework not only presents design patterns to find test cases for a target model but also reduces development time by using common functions provided in the framework. We show the effectiveness and efficiency of the proposed framework with two case studies. The framework improves the productivity by about 50% when changing the type of a model.

  4. Hydrogeologic Framework Model for the Saturated Zone Site Scale flow and Transport Model

    Energy Technology Data Exchange (ETDEWEB)

    T. Miller

    2004-11-15

    The purpose of this report is to document the 19-unit, hydrogeologic framework model (19-layer version, output of this report) (HFM-19) with regard to input data, modeling methods, assumptions, uncertainties, limitations, and validation of the model results in accordance with AP-SIII.10Q, Models. The HFM-19 is developed as a conceptual model of the geometric extent of the hydrogeologic units at Yucca Mountain and is intended specifically for use in the development of the ''Saturated Zone Site-Scale Flow Model'' (BSC 2004 [DIRS 170037]). Primary inputs to this model report include the GFM 3.1 (DTN: MO9901MWDGFM31.000 [DIRS 103769]), borehole lithologic logs, geologic maps, geologic cross sections, water level data, topographic information, and geophysical data as discussed in Section 4.1. Figure 1-1 shows the information flow among all of the saturated zone (SZ) reports and the relationship of this conceptual model in that flow. The HFM-19 is a three-dimensional (3-D) representation of the hydrogeologic units surrounding the location of the Yucca Mountain geologic repository for spent nuclear fuel and high-level radioactive waste. The HFM-19 represents the hydrogeologic setting for the Yucca Mountain area that covers about 1,350 km2 and includes a saturated thickness of about 2.75 km. The boundaries of the conceptual model were primarily chosen to be coincident with grid cells in the Death Valley regional groundwater flow model (DTN: GS960808312144.003 [DIRS 105121]) such that the base of the site-scale SZ flow model is consistent with the base of the regional model (2,750 meters below a smoothed version of the potentiometric surface), encompasses the exploratory boreholes, and provides a framework over the area of interest for groundwater flow and radionuclide transport modeling. In depth, the model domain extends from land surface to the base of the regional groundwater flow model (D'Agnese et al. 1997 [DIRS 100131], p 2). For the site

  5. Baltes' SOC model of successful ageing as a potential framework for stroke rehabilitation.

    Science.gov (United States)

    Donnellan, C; O'Neill, D

    2014-01-01

    The aim of this paper is to explore approaches used to address some stroke rehabilitation interventions and to examine the potential use of one of the life-span theories called the Baltes' model of selective optimisation with compensation (SOC) as a potential framework. Some of the key considerations for a stroke rehabilitation intervention framework are highlighted including accommodating for the life management changes post stroke, alterations in self-regulation, acknowledge losses and focusing on a person-centred approach for transition from acute rehabilitation to the home or community setting. The Baltes' SOC model is then described in terms of these considerations for a stroke rehabilitation intervention framework. The Baltes' SOC model may offer further insights, including ageing considerations, for stroke rehabilitation approaches and interventions. It has potential to facilitate some of the necessary complexities of adjustment required in stroke rehabilitation. However, further development in terms of empirical support is required for using the model as a framework to structure stroke rehabilitation intervention. Implications for Rehabilitation There is a scarcity of theoretical frameworks that can facilitate and be inclusive for all the necessary complexities of adjustment, required in stroke rehabilitation. In addition to motor recovery post stroke, rehabilitation intervention frameworks should be goal orientated; address self-regulatory processes; be person-centred and use a common language for goal planning, setting and attainment. The Baltes' SOC model is one such framework that may address some of the considerations for stroke rehabilitation, including motor recovery and other life management aspects.

  6. Performance comparison of 850-nm and 1550-nm VCSELs exploiting OOK, OFDM, and 4-PAM over SMF/MMF links for low-cost optical interconnects

    DEFF Research Database (Denmark)

    Karinou, Fotini; Deng, Lei; Rodes Lopez, Roberto

    2013-01-01

    modulation (4-PAM), for the 1550-nm transmitter over SMF and MMF links and we compare it to the data-rate equivalent NRZ-OOK. The extensive performance comparison under various transmission scenarios shows the superiority of 1550-nm single-mode VCSEL compared to its multi-mode 850-nm counterpart. Moreover......, OFDM/DD and 4-PAM in conjunction with low-cost, inexpensive VCSELs as transmitters prove to be an enabling technology for next-generation WDM, point-to-point, short-reach, SMF/MMF optical interconnects and potential candidates to substitute NRZ-OOK. Nevertheless, the sensitivity requirements are higher...

  7. IM/DD vs. 4-PAM Using a 1550-nm VCSEL over Short-Range SMF/MMF Links for Optical Interconnects

    DEFF Research Database (Denmark)

    Karinou, Fotini; Rodes Lopez, Roberto; Prince, Kamau

    2013-01-01

    We experimentally compare the performance of 10.9-Gb/s IM/DD and 5-GBd 4-PAM modulation formats over 5-km SMF and 1-km MMF links, employing a commercially-available 1550-nm VCSEL as an enabling technology for use in optical interconnects.......We experimentally compare the performance of 10.9-Gb/s IM/DD and 5-GBd 4-PAM modulation formats over 5-km SMF and 1-km MMF links, employing a commercially-available 1550-nm VCSEL as an enabling technology for use in optical interconnects....

  8. A model-based framework for the analysis of team communication in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yun Hyung [Knowledge and Information Management Department, Korea Institute of Nuclear Safety, 19 Guseong-Dong, Yuseong-Gu, Daejeon 335-338 (Korea, Republic of)], E-mail: yhchung@kins.re.kr; Yoon, Wan Chul [Intelligent Service Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-Dong, Yuseong-Gu, Daejeon 305-701 (Korea, Republic of); Min, Daihwan [Department of MIS, Korea University, 208 Seochang-Dong, Jochiwon-Eup, Yongi-Gun, Choongnam 339-700 (Korea, Republic of)

    2009-06-15

    Advanced human-machine interfaces are rapidly changing the interaction between humans and systems, with the level of abstraction of the presented information, the human task characteristics, and the modes of communication all affected. To accommodate the changes in the human/system co-working environment, an extended communication analysis framework is needed that can describe and relate the tasks, verbal exchanges, and information interface. This paper proposes an extended analytic framework, referred to as the H-H-S (human-human-system) communication analysis framework, which can model the changes in team communication that are emerging in these new working environments. The stage-specific decision-making model and analysis tool of the proposed framework make the analysis of team communication easier by providing visual clues. The usefulness of the proposed framework is demonstrated with an in-depth comparison of the characteristics of communication in the conventional and advanced main control rooms of nuclear power plants.

  9. A framework for modeling interregional population distribution and economic growth.

    Science.gov (United States)

    Ledent, J; Gordon, P

    1981-01-01

    "An integrated model is proposed to capture economic and demographic interactions in a system of regions. This model links the interregional economic model of Isard (1960) and the interregional demographic model of Rogers (1975) via functions describing consumption and migration patterns. Migration rates are determined jointly with labor force participation rates and unemployment rates."

  10. Framework of Pattern Recognition Model Based on the Cognitive Psychology

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    According to the fundamental theory of visual cognition mechanism and cognitive psychology,the visual pattern recognition model is introduced briefly.Three pattern recognition models,i.e.template-based matching model,prototype-based matching model and feature-based matching model are built and discussed separately.In addition,the influence of object background information and visual focus point to the result of pattern recognition is also discussed with the example of recognition for fuzzy letters and figures.

  11. Poly(ethylene glycol) (PEG) in a Polyethylene (PE) Framework: A Simple Model for Simulation Studies of a Soluble Polymer in an Open Framework.

    Science.gov (United States)

    Xie, Liangxu; Chan, Kwong-Yu; Quirke, Nick

    2017-08-16

    Canonical molecular dynamics simulations are performed to investigate the behavior of single-chain and multiple-chain poly(ethylene glycol) (PEG) contained within a cubic framework spanned by polyethylene (PE) chains. This simple model is the first of its kind to study the chemical physics of polymer-threaded organic frameworks, which are materials with potential applications in catalysis and separation processes. For a single-chain 9-mer, 14-mer, and 18-mer in a small framework, the PEG will interact strongly with the framework and assume a more linear geometry chain with an increased radius of gyration Rg compared to that of a large framework. The interaction between PEG and the framework decreases with increasing mesh size in both vacuum and water. In the limit of a framework with an infinitely large cavity (infinitely long linkers), PEG behavior approaches simulation results without a framework. The solvation of PEG is simulated by adding explicit TIP3P water molecules to a 6-chain PEG 14-mer aggregate confined in a framework. The 14-mer chains are readily solvated and leach out of a large 2.6 nm mesh framework. There are fewer water-PEG interactions in a small 1.0 nm mesh framework, as indicated by a smaller number of hydrogen bonds. The PEG aggregate, however, still partially dissolves but is retained within the 1.0 nm framework. The preliminary results illustrate the effectiveness of the simple model in studying polymer-threaded framework materials and in optimizing polymer or framework parameters for high performance.

  12. Modeling the marketing strategy-performance relationship : towards an hierarchical marketing performance framework

    NARCIS (Netherlands)

    Huizingh, Eelko K.R.E.; Zengerink, Evelien

    2001-01-01

    Accurate measurement of marketing performance is an important topic for both marketing academics and marketing managers. Many researchers have recognized that marketing performance measurement should go beyond financial measurement. In this paper we propose a conceptual framework that models

  13. Modeling the marketing strategy-performance relationship : towards an hierarchical marketing performance framework

    NARCIS (Netherlands)

    Huizingh, Eelko K.R.E.; Zengerink, Evelien

    2001-01-01

    Accurate measurement of marketing performance is an important topic for both marketing academics and marketing managers. Many researchers have recognized that marketing performance measurement should go beyond financial measurement. In this paper we propose a conceptual framework that models marketi

  14. The Regional Hydrologic Extremes Assessment System: A software framework for hydrologic modeling and data assimilation

    National Research Council Canada - National Science Library

    Konstantinos M Andreadis; Narendra Das; Dimitrios Stampoulis; Amor Ines; Joshua B Fisher; Stephanie Granger; Jessie Kawata; Eunjin Han; Ali Behrangi

    2017-01-01

    The Regional Hydrologic Extremes Assessment System (RHEAS) is a prototype software framework for hydrologic modeling and data assimilation that automates the deployment of water resources nowcasting and forecasting applications...

  15. A reference model and technical framework for mobile social software for learning

    NARCIS (Netherlands)

    De Jong, Tim; Specht, Marcus; Koper, Rob

    2008-01-01

    De Jong, T., Specht, M., & Koper, R. (2008). A reference model and technical framework for mobile social software for learning. Presented at the IADIS m-learning 2008 Conference. April, 11-13, 2008, Carvoeiro, Portugal.

  16. The IIR evaluation model: a framework for evaluation of interactive information retrieval systems

    Directory of Open Access Journals (Sweden)

    Borlund Pia

    2003-01-01

    Full Text Available An alternative approach to evaluation of interactive information retrieval (IIR systems is proposed. The model provides a framework for the collection and analysis of IR interaction data.

  17. A flexible and efficient multi-model framework in support of water management

    Science.gov (United States)

    Wolfs, Vincent; Tran Quoc, Quan; Willems, Patrick

    2016-05-01

    Flexible, fast and accurate water quantity models are essential tools in support of water management. Adjustable levels of model detail and the ability to handle varying spatial and temporal resolutions are requisite model characteristics to ensure that such models can be employed efficiently in various applications. This paper uses a newly developed flexible modelling framework that aims to generate such models. The framework incorporates several approaches to model catchment hydrology, rivers and floodplains, and the urban drainage system by lumping processes on different levels. To illustrate this framework, a case study of integrated hydrological-hydraulic modelling is elaborated for the Grote Nete catchment in Belgium. Three conceptual rainfall-runoff models (NAM, PDM and VHM) were implemented in a generalized model structure, allowing flexibility in the spatial resolution by means of an innovative disaggregation/aggregation procedure. They were linked to conceptual hydraulic models of the rivers in the catchment, which were developed by means of an advanced model structure identification and calibration procedure. The conceptual models manage to emulate the simulation results of a detailed full hydrodynamic model accurately. The models configured using the approaches of this framework are well-suited for many applications in water management due to their very short calculation time, interfacing possibilities and adjustable level of detail.

  18. A framework for sharing and integrating remote sensing and GIS models based on Web service.

    Science.gov (United States)

    Chen, Zeqiang; Lin, Hui; Chen, Min; Liu, Deer; Bao, Ying; Ding, Yulin

    2014-01-01

    Sharing and integrating Remote Sensing (RS) and Geographic Information System/Science (GIS) models are critical for developing practical application systems. Facilitating model sharing and model integration is a problem for model publishers and model users, respectively. To address this problem, a framework based on a Web service for sharing and integrating RS and GIS models is proposed in this paper. The fundamental idea of the framework is to publish heterogeneous RS and GIS models into standard Web services for sharing and interoperation and then to integrate the RS and GIS models using Web services. For the former, a "black box" and a visual method are employed to facilitate the publishing of the models as Web services. For the latter, model integration based on the geospatial workflow and semantic supported marching method is introduced. Under this framework, model sharing and integration is applied for developing the Pearl River Delta water environment monitoring system. The results show that the framework can facilitate model sharing and model integration for model publishers and model users.

  19. NONLINEAR EXTENSION OF ASYMMETRIC GARCH MODEL WITHIN NEURAL NETWORK FRAMEWORK

    Directory of Open Access Journals (Sweden)

    Josip Arnerić

    2016-05-01

    Full Text Available The importance of volatility for all market participants has led to the development and application of various econometric models. The most popular models in modelling volatility are GARCH type models because they can account excess kurtosis and asymmetric effects of financial time series. Since standard GARCH(1,1 model usually indicate high persistence in the conditional variance, the empirical researches turned to GJR-GARCH model and reveal its superiority in fitting the asymmetric heteroscedasticity in the data. In order to capture both asymmetry and nonlinearity in data, the goal of this paper is to develop a parsimonious NN model as an extension to GJR-GARCH model and to determine if GJR-GARCH-NN outperforms the GJR-GARCH model.

  20. An Integrated Qualitative and Quantitative Biochemical Model Learning Framework Using Evolutionary Strategy and Simulated Annealing.

    Science.gov (United States)

    Wu, Zujian; Pang, Wei; Coghill, George M

    2015-01-01

    Both qualitative and quantitative model learning frameworks for biochemical systems have been studied in computational systems biology. In this research, after introducing two forms of pre-defined component patterns to represent biochemical models, we propose an integrative qualitative and quantitative modelling framework for inferring biochemical systems. In the proposed framework, interactions between reactants in the candidate models for a target biochemical system are evolved and eventually identified by the application of a qualitative model learning approach with an evolution strategy. Kinetic rates of the models generated from qualitative model learning are then further optimised by employing a quantitative approach with simulated annealing. Experimental results indicate that our proposed integrative framework is feasible to learn the relationships between biochemical reactants qualitatively and to make the model replicate the behaviours of the target system by optimising the kinetic rates quantitatively. Moreover, potential reactants of a target biochemical system can be discovered by hypothesising complex reactants in the synthetic models. Based on the biochemical models learned from the proposed framework, biologists can further perform experimental study in wet laboratory. In this way, natural biochemical systems can be better understood.

  1. National culture and business model change: a framework for successful expansions

    DEFF Research Database (Denmark)

    Dalby, J.; Nielsen, L.S.; Lueg, Rainer;

    2014-01-01

    Dalby, J., Nielsen, Lueg, R., L. S., Pedersen, L., Tomoni, A. C. 2014. National culture and business model change: a framework for successful expansions. Journal of Enterprising Culture, 22(4): 379-498.......Dalby, J., Nielsen, Lueg, R., L. S., Pedersen, L., Tomoni, A. C. 2014. National culture and business model change: a framework for successful expansions. Journal of Enterprising Culture, 22(4): 379-498....

  2. Super-Exponential Solution in Markovian Supermarket Models: Framework and Challenge

    OpenAIRE

    Li, Quan-Lin

    2011-01-01

    Marcel F. Neuts opened a key door in numerical computation of stochastic models by means of phase-type (PH) distributions and Markovian arrival processes (MAPs). To celebrate his 75th birthday, this paper reports a more general framework of Markovian supermarket models, including a system of differential equations for the fraction measure and a system of nonlinear equations for the fixed point. To understand this framework heuristically, this paper gives a detailed analysis for three importan...

  3. A scalable delivery framework and a pricing model for streaming media with advertisements

    Science.gov (United States)

    Al-Hadrusi, Musab; Sarhan, Nabil J.

    2008-01-01

    This paper presents a delivery framework for streaming media with advertisements and an associated pricing model. The delivery model combines the benefits of periodic broadcasting and stream merging. The advertisements' revenues are used to subsidize the price of the media content. The pricing is determined based on the total ads' viewing time. Moreover, this paper presents an efficient ad allocation scheme and three modified scheduling policies that are well suited to the proposed delivery framework. Furthermore, we study the effectiveness of the delivery framework and various scheduling polices through extensive simulation in terms of numerous metrics, including customer defection probability, average number of ads viewed per client, price, arrival rate, profit, and revenue.

  4. Integrating water quality modeling with ecological risk assessment for nonpoint source pollution control: A conceptual framework

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y.D.; McCutcheon, S.C.; Rasmussen, T.C.; Nutter, W.L.; Carsel, R.F.

    1993-01-01

    The historical development of water quality protection goals and strategies in the United States is reviewed. The review leads to the identification and discussion of three components (i.e., management mechanism, environmental investigation approaches, and environmental assessment and criteria) for establishing a management framework for nonpoint source pollution control. Water quality modeling and ecological risk assessment are the two most important and promising approaches to the operation of the proposed management framework. A conceptual framework that shows the general integrative relationships between water quality modeling and ecological risk assessment is presented. (Copyright (c) 1993 IAWQ.)

  5. BioASF: a framework for automatically generating executable pathway models specified in BioPAX.

    Science.gov (United States)

    Haydarlou, Reza; Jacobsen, Annika; Bonzanni, Nicola; Feenstra, K Anton; Abeln, Sanne; Heringa, Jaap

    2016-06-15

    Biological pathways play a key role in most cellular functions. To better understand these functions, diverse computational and cell biology researchers use biological pathway data for various analysis and modeling purposes. For specifying these biological pathways, a community of researchers has defined BioPAX and provided various tools for creating, validating and visualizing BioPAX models. However, a generic software framework for simulating BioPAX models is missing. Here, we attempt to fill this gap by introducing a generic simulation framework for BioPAX. The framework explicitly separates the execution model from the model structure as provided by BioPAX, with the advantage that the modelling process becomes more reproducible and intrinsically more modular; this ensures natural biological constraints are satisfied upon execution. The framework is based on the principles of discrete event systems and multi-agent systems, and is capable of automatically generating a hierarchical multi-agent system for a given BioPAX model. To demonstrate the applicability of the framework, we simulated two types of biological network models: a gene regulatory network modeling the haematopoietic stem cell regulators and a signal transduction network modeling the Wnt/β-catenin signaling pathway. We observed that the results of the simulations performed using our framework were entirely consistent with the simulation results reported by the researchers who developed the original models in a proprietary language. The framework, implemented in Java, is open source and its source code, documentation and tutorial are available at http://www.ibi.vu.nl/programs/BioASF CONTACT: j.heringa@vu.nl. © The Author 2016. Published by Oxford University Press.

  6. Finite element model updating using bayesian framework and modal properties

    CSIR Research Space (South Africa)

    Marwala, T

    2005-01-01

    Full Text Available Finite element (FE) models are widely used to predict the dynamic characteristics of aerospace structures. These models often give results that differ from measured results and therefore need to be updated to match measured results. Some...

  7. A Generic Software Framework for Data Assimilation and Model Calibration

    NARCIS (Netherlands)

    Van Velzen, N.

    2010-01-01

    The accuracy of dynamic simulation models can be increased by using observations in conjunction with a data assimilation or model calibration algorithm. However, implementing such algorithms usually increases the complexity of the model software significantly. By using concepts from object oriented

  8. Integration of GFDL Data Portal into FMS Runtime Environment (FRE) modeling framework

    Science.gov (United States)

    Nikonov, S.; Balaji, V.; Rehbein, C.; Malysheva, Y.

    2009-12-01

    The complexities of modern climate modeling and the tremendous volume of model output data require advancements in the development of a climate model data dissemination infrastructure, stressing tight integration with the modeling framework. It is particularly important on the threshold of the IPCC Assessment Report 5, where data volume growth is expected to be two orders of magnitude beyond what was required for AR4. Shared infrastructure between the modeling framework and the data preparation and publishing framework will more easily allow the automation of three important phases of data dissemination: - Proper metadata annotation of datasets, including but not limited to model principles, configurations and simulation details; - Making data available using community-adopted standards; - Web-based data publishing which can feature semantic discoverability, navigation, federalization and analysis of published datasets. A framework which integrates the running of models with the publishing of data is a mutually profitable process. Climate model authors would have a powerful tool for composing and analyzing conducted experiments using FRE and a well-organized metadata database. In turn, those maintaining the data access portal gain direct access to metadata used in FMS that is useful in the process of publishing data. The kernel of this integration is a model development database that contains metadata describing all aspects of the modeling process, ranging from model configuration through model runtime, including model output analysis and data publishing. The database is populated using an automated process that collects model information and metadata via the model's XML-based configuration file. The framework also allows one to work backwards, generating synthesized experiment configurations using experiment components established in prior conducted experiments. In addition, a web-based graphical interface grants the model author a friendly and comfortable way to

  9. Integration of the Radiation Belt Environment Model Into the Space Weather Modeling Framework

    Science.gov (United States)

    Glocer, A.; Toth, G.; Fok, M.; Gombosi, T.; Liemohn, M.

    2009-01-01

    We have integrated the Fok radiation belt environment (RBE) model into the space weather modeling framework (SWMF). RBE is coupled to the global magnetohydrodynamics component (represented by the Block-Adaptive-Tree Solar-wind Roe-type Upwind Scheme, BATS-R-US, code) and the Ionosphere Electrodynamics component of the SWMF, following initial results using the Weimer empirical model for the ionospheric potential. The radiation belt (RB) model solves the convection-diffusion equation of the plasma in the energy range of 10 keV to a few MeV. In stand-alone mode RBE uses Tsyganenko's empirical models for the magnetic field, and Weimer's empirical model for the ionospheric potential. In the SWMF the BATS-R-US model provides the time dependent magnetic field by efficiently tracing the closed magnetic field-lines and passing the geometrical and field strength information to RBE at a regular cadence. The ionosphere electrodynamics component uses a two-dimensional vertical potential solver to provide new potential maps to the RBE model at regular intervals. We discuss the coupling algorithm and show some preliminary results with the coupled code. We run our newly coupled model for periods of steady solar wind conditions and compare our results to the RB model using an empirical magnetic field and potential model. We also simulate the RB for an active time period and find that there are substantial differences in the RB model results when changing either the magnetic field or the electric field, including the creation of an outer belt enhancement via rapid inward transport on the time scale of tens of minutes.

  10. VOML: A Framework for Modelling Virtual Organizations and Virtual Breeding Environment

    Directory of Open Access Journals (Sweden)

    Noor Jahan Rajper

    2015-07-01

    Full Text Available This paper presents the VOML (Virtual Organization Modelling Language framework. VOML is a formal approach for specifying VOs (Virtual Organizations and their VBEs (Virtual Breeding Environments.The VOML framework allows domain users to model a system in terms of their domain terminology and from that domain specific model IT community can derive a complete operational model closer to underlying execution environment. The framework is a collection of three sub-languages, each covering different aspects which are considered paramount at a particular level of VO representation. We present VOML and its underlying methodological approach in detail and demonstrate how to model VOs. Our focus will be on the methodological approach that VOML supports and on the language primitives that VOML offers for modelling VOs.

  11. Physical Models of Galaxy Formation in a Cosmological Framework

    OpenAIRE

    Somerville, Rachel S.; Davé, Romeel

    2014-01-01

    Modeling galaxy formation in a cosmological context presents one of the greatest challenges in astrophysics today, due to the vast range of scales and numerous physical processes involved. Here we review the current status of models that employ two leading techniques to simulate the physics of galaxy formation: semi-analytic models and numerical hydrodynamic simulations. We focus on a set of observational targets that describe the evolution of the global and structural properties of galaxies ...

  12. Viewpoints: a framework for object oriented database modelling and distribution

    Directory of Open Access Journals (Sweden)

    Fouzia Benchikha

    2006-01-01

    Full Text Available The viewpoint concept has received widespread attention recently. Its integration into a data model improves the flexibility of the conventional object-oriented data model and allows one to improve the modelling power of objects. The viewpoint paradigm can be used as a means of providing multiple descriptions of an object and as a means of mastering the complexity of current database systems enabling them to be developed in a distributed manner. The contribution of this paper is twofold: to define an object data model integrating viewpoints in databases and to present a federated database system integrating multiple sources following a local-as-extended-view approach.

  13. Assessing uncertainties in global cropland futures using a conditional probabilistic modelling framework

    NARCIS (Netherlands)

    Engström, Kerstin; Olin, Stefan; Rounsevell, Mark D A; Brogaard, Sara; Van Vuuren, Detlef P.; Alexander, Peter; Murray-Rust, Dave; Arneth, Almut

    2016-01-01

    We present a modelling framework to simulate probabilistic futures of global cropland areas that are conditional on the SSP (shared socio-economic pathway) scenarios. Simulations are based on the Parsimonious Land Use Model (PLUM) linked with the global dynamic vegetation model LPJ-GUESS (Lund-Potsd

  14. An ice sheet model validation framework for the Greenland ice sheet

    NARCIS (Netherlands)

    Price, Stephen F.; Hoffman, Matthew J.; Bonin, Jennifer A.; Howat, Ian M.; Neumann, Thomas; Saba, Jack; Tezaur, Irina; Guerber, Jeffrey; Chambers, Don P.; Evans, Katherine J.; Kennedy, Joseph H.; Lenaerts, Jan; Lipscomb, William H.; Perego, Mauro; Salinger, Andrew G.; Tuminaro, Raymond S.; Van Den Broeke, Michiel R.; Nowicki, Sophie M J

    2017-01-01

    We propose a new ice sheet model validation framework - the Cryospheric Model Comparison Tool (CmCt) - that takes advantage of ice sheet altimetry and gravimetry observations collected over the past several decades and is applied here to modeling of the Greenland ice sheet. We use realistic

  15. Assessing uncertainties in global cropland futures using a conditional probabilistic modelling framework

    NARCIS (Netherlands)

    Engström, Kerstin; Olin, Stefan; Rounsevell, Mark D A; Brogaard, Sara; Van Vuuren, Detlef P.; Alexander, Peter; Murray-Rust, Dave; Arneth, Almut

    2016-01-01

    We present a modelling framework to simulate probabilistic futures of global cropland areas that are conditional on the SSP (shared socio-economic pathway) scenarios. Simulations are based on the Parsimonious Land Use Model (PLUM) linked with the global dynamic vegetation model LPJ-GUESS

  16. Deep Modeling: Circuit Characterization Using Theory Based Models in a Data Driven Framework

    Energy Technology Data Exchange (ETDEWEB)

    Bolme, David S [ORNL; Mikkilineni, Aravind K [ORNL; Rose, Derek C [ORNL; Yoginath, Srikanth B [ORNL; Holleman, Jeremy [University of Tennessee, Knoxville (UTK); Judy, Mohsen [University of Tennessee, Knoxville (UTK), Department of Electrical Engineering and Computer Science

    2017-01-01

    Analog computational circuits have been demonstrated to provide substantial improvements in power and speed relative to digital circuits, especially for applications requiring extreme parallelism but only modest precision. Deep machine learning is one such area and stands to benefit greatly from analog and mixed-signal implementations. However, even at modest precisions, offsets and non-linearity can degrade system performance. Furthermore, in all but the simplest systems, it is impossible to directly measure the intermediate outputs of all sub-circuits. The result is that circuit designers are unable to accurately evaluate the non-idealities of computational circuits in-situ and are therefore unable to fully utilize measurement results to improve future designs. In this paper we present a technique to use deep learning frameworks to model physical systems. Recently developed libraries like TensorFlow make it possible to use back propagation to learn parameters in the context of modeling circuit behavior. Offsets and scaling errors can be discovered even for sub-circuits that are deeply embedded in a computational system and not directly observable. The learned parameters can be used to refine simulation methods or to identify appropriate compensation strategies. We demonstrate the framework using a mixed-signal convolution operator as an example circuit.

  17. Toward the Establishment of a Common Framework for Model Evaluation

    DEFF Research Database (Denmark)

    Olesen, H. R.

    1996-01-01

    Proceedings of the Twenty-first NATO/CCMS International Technical Meeting on Air Pollution Modeling and Its Application, held November 6-10 1995, in Baltimore, Maryland.......Proceedings of the Twenty-first NATO/CCMS International Technical Meeting on Air Pollution Modeling and Its Application, held November 6-10 1995, in Baltimore, Maryland....

  18. Abdominal surgery process modeling framework for simulation using spreadsheets.

    Science.gov (United States)

    Boshkoska, Biljana Mileva; Damij, Talib; Jelenc, Franc; Damij, Nadja

    2015-08-01

    We provide a continuation of the existing Activity Table Modeling methodology with a modular spreadsheets simulation. The simulation model developed is comprised of 28 modeling elements for the abdominal surgery cycle process. The simulation of a two-week patient flow in an abdominal clinic with 75 beds demonstrates the applicability of the methodology. The simulation does not include macros, thus programming experience is not essential for replication or upgrading the model. Unlike the existing methods, the proposed solution employs a modular approach for modeling the activities that ensures better readability, the possibility of easily upgrading the model with other activities, and its easy extension and connectives with other similar models. We propose a first-in-first-served approach for simulation of servicing multiple patients. The uncertain time duration of the activities is modeled using the function "rand()". The patients movements from one activity to the next one is tracked with nested "if()" functions, thus allowing easy re-creation of the process without the need of complex programming. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  19. An integrated hydrologic modeling framework for coupling SWAT with MODFLOW

    Science.gov (United States)

    The Soil and Water Assessment Tool (SWAT), MODFLOW, and Energy Balance based Evapotranspiration (EB_ET) models are extensively used to estimate different components of the hydrological cycle. Surface and subsurface hydrological processes are modeled in SWAT but limited to the extent of shallow aquif...

  20. A MULTISCALE, CELL-BASED FRAMEWORK FOR MODELING CANCER DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    JIANG, YI [Los Alamos National Laboratory

    2007-01-16

    Cancer remains to be one of the leading causes of death due to diseases. We use a systems approach that combines mathematical modeling, numerical simulation, in vivo and in vitro experiments, to develop a predictive model that medical researchers can use to study and treat cancerous tumors. The multiscale, cell-based model includes intracellular regulations, cellular level dynamics and intercellular interactions, and extracellular level chemical dynamics. The intracellular level protein regulations and signaling pathways are described by Boolean networks. The cellular level growth and division dynamics, cellular adhesion and interaction with the extracellular matrix is described by a lattice Monte Carlo model (the Cellular Potts Model). The extracellular dynamics of the signaling molecules and metabolites are described by a system of reaction-diffusion equations. All three levels of the model are integrated through a hybrid parallel scheme into a high-performance simulation tool. The simulation results reproduce experimental data in both avasular tumors and tumor angiogenesis. By combining the model with experimental data to construct biologically accurate simulations of tumors and their vascular systems, this model will enable medical researchers to gain a deeper understanding of the cellular and molecular interactions associated with cancer progression and treatment.

  1. A business model for IPTV service: A dynamic framework

    NARCIS (Netherlands)

    Bouwman, H.; Zhengjia, M.; Duin, P. van der; Limonard, S.

    2008-01-01

    Purpose - The purpose of this paper is to investigate a possible business model for telecom operators for entering the IPTV (digital television) market. Design/methodology/approach - The approach takes the form of a case study, literature search and interviews. Findings - The IPTV business model alw

  2. Physical Models of Galaxy Formation in a Cosmological Framework

    Science.gov (United States)

    Somerville, Rachel S.; Davé, Romeel

    2015-08-01

    Modeling galaxy formation in a cosmological context presents one of the greatest challenges in astrophysics today due to the vast range of scales and numerous physical processes involved. Here we review the current status of models that employ two leading techniques to simulate the physics of galaxy formation: semianalytic models and numerical hydrodynamic simulations. We focus on a set of observational targets that describe the evolution of the global and structural properties of galaxies from roughly cosmic high noon (z â¼ 2-3) to the present. Although minor discrepancies remain, overall, models show remarkable convergence among different methods and make predictions that are in qualitative agreement with observations. Modelers have converged on a core set of physical processes that are critical for shaping galaxy properties. This core set includes cosmological accretion, strong stellar-driven winds that are more efficient at low masses, black hole feedback that preferentially suppresses star formation at high masses, and structural and morphological evolution through merging and environmental processes. However, all cosmological models currently adopt phenomenological implementations of many of these core processes, which must be tuned to observations. Many details of how these diverse processes interact within a hierarchical structure formation setting remain poorly understood. Emerging multiscale simulations are helping to bridge the gap between stellar and cosmological scales, placing models on a firmer, more physically grounded footing. Concurrently, upcoming telescope facilities will provide new challenges and constraints for models, particularly by directly constraining inflows and outflows through observations of gas in and around galaxies.

  3. A Framework for Modeling and Analyzing Complex Distributed Systems

    Science.gov (United States)

    2005-08-15

    tool Kronos , Hybrid Systems HI, Verification and Control, Springer-Verlag, pages 208-219, LNCS, volume 1066, 1996 [16] Roberto De Prisco, Alan Fekete...Open- Kronos model checker for timed automata. Monte Carlo model checking has already been implemented in Open- Kronos and has demonstrated significant

  4. Instant e-Teaching Framework Model for Live Online Teaching

    CERN Document Server

    Safei, Suhailan; Rose, Ahmad Nazari Mohd; Rahman, Mohd Nordin Abdul

    2011-01-01

    Instant e-Teaching is a new concept that supplements e-Teaching and e-Learning environment in providing a full and comprehensive modern education styles. The e-Learning technology depicts the concept of enabling self-learning among students on a certain subject using online reference and materials. While the instant e-teaching requires 'face-to-face' characteristic between teacher and student to simultaneously execute actions and gain instant responses. The word instant enhances the e- Teaching with the concept of real time teaching. The challenge to exercise online and instant teaching is not just merely relying on the technologies and system efficiency, but it needs to satisfy the usability and friendliness of the system as to replicate the traditional class environment during the deliveries of the class. For this purpose, an instant e-Teaching framework is been developed that will emulate a dedicated virtual classroom, and primarily designed for synchronous and live sharing of current teaching notes. The m...

  5. Physical Models of Galaxy Formation in a Cosmological Framework

    CERN Document Server

    Somerville, Rachel S

    2014-01-01

    Modeling galaxy formation in a cosmological context presents one of the greatest challenges in astrophysics today, due to the vast range of scales and numerous physical processes involved. Here we review the current status of models that employ two leading techniques to simulate the physics of galaxy formation: semi-analytic models and numerical hydrodynamic simulations. We focus on a set of observational targets that describe the evolution of the global and structural properties of galaxies from roughly Cosmic High Noon ($z\\sim 2-3$) to the present. Although minor discrepancies remain, overall, models show remarkable convergence between different methods and make predictions that are in qualitative agreement with observations. Modelers seem to have converged on a core set of physical processes that are critical for shaping galaxy properties. This core set includes cosmological accretion, strong stellar-driven winds that are more efficient at low masses, black hole feedback that preferentially suppresses star...

  6. Comparison of Hugoniots calculated for aluminum in the framework of three quantum-statistical models

    CERN Document Server

    Kadatskiy, Maxim A

    2015-01-01

    The results of calculations of thermodynamic properties of aluminum under shock compression in the framework of the Thomas--Fermi model, the Thomas--Fermi model with quantum and exchange corrections and the Hartree--Fock--Slater model are presented. The influences of the thermal motion and the interaction of ions are taken into account in the framework of three models: the ideal gas, the one-component plasma and the charged hard spheres. Calculations are performed in the pressure range from 1 to $10^7$ GPa. Calculated Hugoniots are compared with available experimental data.

  7. Comparison of Hugoniots calculated for aluminum in the framework of three quantum-statistical models

    Science.gov (United States)

    Kadatskiy, M. A.; Khishchenko, K. V.

    2015-11-01

    The results of calculations of thermodynamic properties of aluminum under shock compression in the framework of the Thomas-Fermi model, the Thomas-Fermi model with quantum and exchange corrections and the Hartree-Fock-Slater model are presented. The influences of the thermal motion and the interaction of ions are taken into account in the framework of three models: the ideal gas, the one-component plasma and the charged hard spheres. Calculations are performed in the pressure range from 1 to 107 GPa. Calculated Hugoniots are compared with available experimental data.

  8. Total Quality Management (TQM) framework for e-learning based on EFQM and Kirkpatrick models

    OpenAIRE

    Jeanne Schreurs

    2006-01-01

    The EFQM excellence model is a famous quality management tool. We have translated it to be useful in e-learning quality management. EFQM will be used as a framework for self-evaluation. We developed the e-learning stakeholder model. We identified the main criterion and positioned them in the stakeholder model. We present short the Kirkpatrick evaluation model of e-learning. We developed a Kirkpatrick-EFQM self-assessment framework. We propose the limited learner-centric self-assessment frame...

  9. MoVES - A Framework for Modelling and Verifying Embedded Systems

    DEFF Research Database (Denmark)

    Brekling, Aske Wiid; Hansen, Michael Reichhardt; Madsen, Jan

    2009-01-01

    The MoVES framework is being developed to assist in the early phases of embedded systems design. A system is modelled as an application running on an execution platform. The application is modelled through the individual tasks, and the execution platform is modelled through the processing elements...... consumption. A simple specification language for embedded systems and a verification backend are presented. The framework has a modular, parameterized structure supporting easy extension and adaptation of the specification language as well as of the verification backend. We show, using a number of small...... examples, how MoVES can be used to model and analyze embedded systems....

  10. A framework to establish credibility of computational models in biology.

    Science.gov (United States)

    Patterson, Eann A; Whelan, Maurice P

    2017-10-01

    Computational models in biology and biomedical science are often constructed to aid people's understanding of phenomena or to inform decisions with socioeconomic consequences. Model credibility is the willingness of people to trust a model's predictions and is often difficult to establish for computational biology models. A 3 × 3 matrix has been proposed to allow such models to be categorised with respect to their testability and epistemic foundation in order to guide the selection of an appropriate process of validation to supply evidence to establish credibility. Three approaches to validation are identified that can be deployed depending on whether a model is deemed untestable, testable or lies somewhere in between. In the latter two cases, the validation process involves the quantification of uncertainty which is a key output. The issues arising due to the complexity and inherent variability of biological systems are discussed and the creation of 'digital twins' proposed as a means to alleviate the issues and provide a more robust, transparent and traceable route to model credibility and acceptance. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  11. Interaction between GIS and hydrologic model: A preliminary approach using ArcHydro Framework Data Model

    Directory of Open Access Journals (Sweden)

    Silvio Jorge C. Simões

    2013-08-01

    Full Text Available In different regions of Brazil, population growth and economic development can degrade water quality, compromising watershed health and human supply. Because of its ability to combine spatial and temporal data in the same environment and to create water resources management (WRM models, the Geographical Information System (GIS is a powerful tool for managing water resources, preventing floods and estimating water supply. This paper discusses the integration between GIS and hydrological models and presents a case study relating to the upper section of the Paraíba do Sul Basin (Sao Paulo State portion, situated in the Southeast of Brazil. The case study presented in this paper has a database suitable for the basin’s dimensions, including digitized topographic maps at a 50,000 scale. From an ArcGIS®/ArcHydro Framework Data Model, a geometric network was created to produce different raster products. This first grid derived from the digital elevation model grid (DEM is the flow direction map followed by flow accumulation, stream and catchment maps. The next steps in this research are to include the different multipurpose reservoirs situated along the Paraíba do Sul River and to incorporate rainfall time series data in ArcHydro to build a hydrologic data model within a GIS environment in order to produce a comprehensive spatial temporal model.

  12. FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia.

    Science.gov (United States)

    Salvadori, M; Budde, K; Charpentier, B; Klempnauer, J; Nashan, B; Pallardo, L M; Eris, J; Schena, F P; Eisenberger, U; Rostaing, L; Hmissi, A; Aradhye, S

    2006-12-01

    FTY720 is a novel immunomodulator investigated in de novo renal transplantation and other therapeutic areas including multiple sclerosis. This 1-year multicenter, randomized, phase III study in 668 de novo renal transplant patients compared FTY720 2.5 mg plus full-dose cyclosporine (FDC) or FTY720 5.0 mg plus reduced-dose cyclosporine (RDC), with mycophenolate mofetil (MMF) plus FDC. The primary efficacy endpoint was the composite incidence of first treated biopsy-proven acute rejection (BPAR), graft loss, death or premature study discontinuation at month 12. Primary efficacy with FTY720 2.5 mg and MMF (32.4% and 30.2%; p = NS), plus mortality and BPAR incidence, were comparable. Patients receiving FTY720 5.0 mg plus RDC were discontinued from treatment due to increased risk of acute rejection (primary endpoint incidence 47.3%). FTY720 was associated with lower creatinine clearance (month 12: 53.1, 56.0 vs. 65.1 mL/min; p MMF (6.2% and 10.6% vs. 18.1% p MMF; however, FTY720 5.0 mg did not support a 50% reduction in cyclosporine exposure. The cause of macular edema cases and lower creatinine clearance with FTY720 in de novo transplantation needs further investigation.

  13. Next Generation Framework for Aquatic Modeling of the Earth System (NextFrAMES)

    Science.gov (United States)

    Fekete, B. M.; Wollheim, W. M.; Lakhankar, T.; Vorosmarty, C. J.

    2008-12-01

    Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the surrounding IT infrastructure needed to carry out these detailed model computations is growing increasingly complex as well. To be accurate and useful, Earth System models must manage a vast amount of data in heterogenous computing environments ranging from single CPU systems to Beowulf type computer clusters. Scientists developing Earth System models increasingly confront obstacles associated with IT infrastructure. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI) do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc.), they are still considerably complex and often have steep learning curves. Over the course of the last fifteen years ,the University of New Hampshire developed several modeling frameworks independently from the above-mentioned efforts (Data Assembler, Frameworks for Aquatic Modeling of the Earth System and NextFrAMES which is continued at CCNY). While the UNH modeling frameworks have numerous similarities to those developed by other teams, these frameworks, in particular the latest NextFrAMES, represent a novel model development paradigm. While other modeling frameworks focus on providing services to modelers to perform various tasks, NextFrAMES strives to hide all of those services and provide a new approach for modelers to express their scientific thoughts. From a scientific perspective, most models have two core elements: the overall model structure (defining the linkages between the simulated processes

  14. Open Models of Decision Support Towards a Framework

    OpenAIRE

    Diasio, Stephen Ray

    2012-01-01

    Aquesta tesi presenta un marc per als models oberts de suport a les decisions en les organitzacions. El treball es vehicula a través d’un compendi d’articles on s’analitzen els fluxos d’entrada i de sortida de coneixement en les organitzacions, així como les tecnologies existents de suport a les decisions. Es presenten els factors subjacents que impulsen nous models per a formes obertes de suport a la decisió. La tesis presenta un estudi de les distintes tipologies de models de suport a les d...

  15. Extending the Modelling Framework for Gas-Particle Systems

    DEFF Research Database (Denmark)

    Rosendahl, Lasse Aistrup

    , with very good results. Single particle combustion has been tested using a number of different particle combustion models applied to coal and straw particles. Comparing the results of these calculations to measurements on straw burnout, the results indicate that for straw, existing heterogeneous combustion...... models perform well, and may be used in high temperature ranges. Finally, the particle tracking and combustion model is applied to an existing coal and straw co- fuelled burner. The results indicate that again, the straw follows very different trajectories than the coal particles, and also that burnout...

  16. Model Components of the Certification Framework for Geologic Carbon Sequestration Risk Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Oldenburg, Curtis M.; Bryant, Steven L.; Nicot, Jean-Philippe; Kumar, Navanit; Zhang, Yingqi; Jordan, Preston; Pan, Lehua; Granvold, Patrick; Chow, Fotini K.

    2009-06-01

    We have developed a framework for assessing the leakage risk of geologic carbon sequestration sites. This framework, known as the Certification Framework (CF), emphasizes wells and faults as the primary potential leakage conduits. Vulnerable resources are grouped into compartments, and impacts due to leakage are quantified by the leakage flux or concentrations that could potentially occur in compartments under various scenarios. The CF utilizes several model components to simulate leakage scenarios. One model component is a catalog of results of reservoir simulations that can be queried to estimate plume travel distances and times, rather than requiring CF users to run new reservoir simulations for each case. Other model components developed for the CF and described here include fault characterization using fault-population statistics; fault connection probability using fuzzy rules; well-flow modeling with a drift-flux model implemented in TOUGH2; and atmospheric dense-gas dispersion using a mesoscale weather prediction code.

  17. Development of a practical modeling framework for estimating the impact of wind technology on bird populations

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, M.L. [California State Univ., Sacramento, CA (United States); Pollock, K.H. [North Carolina State Univ., Raleigh, NC (United States)

    1997-11-01

    One of the most pressing environmental concerns related to wind project development is the potential for avian fatalities caused by the turbines. The goal of this project is to develop a useful, practical modeling framework for evaluating potential wind power plant impacts that can be generalized to most bird species. This modeling framework could be used to get a preliminary understanding of the likelihood of significant impacts to birds, in a cost-effective way. The authors accomplish this by (1) reviewing the major factors that can influence the persistence of a wild population; (2) briefly reviewing various models that can aid in estimating population status and trend, including methods of evaluating model structure and performance; (3) reviewing survivorship and population projections; and (4) developing a framework for using models to evaluate the potential impacts of wind development on birds.

  18. Development of a practical modeling framework for estimating the impact of wind technology on bird populations

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, M.L. [California State Univ., Sacramento, CA (United States); Pollock, K.H. [North Carolina State Univ., Raleigh, NC (United States)

    1997-11-01

    One of the most pressing environmental concerns related to wind project development is the potential for avian fatalities caused by the turbines. The goal of this project is to develop a useful, practical modeling framework for evaluating potential wind power plant impacts that can be generalized to most bird species. This modeling framework could be used to get a preliminary understanding of the likelihood of significant impacts to birds, in a cost-effective way. The authors accomplish this by (1) reviewing the major factors that can influence the persistence of a wild population; (2) briefly reviewing various models that can aid in estimating population status and trend, including methods of evaluating model structure and performance; (3) reviewing survivorship and population projections; and (4) developing a framework for using models to evaluate the potential impacts of wind development on birds.

  19. Non-local first-order modelling of crowd dynamics: a multidimensional framework with applications

    CERN Document Server

    Bruno, Luca; Tricerri, Paolo; Venuti, Fiammetta

    2010-01-01

    In this work a physical modelling framework is presented, describing the intelligent, non-local, and anisotropic behaviour of pedestrians. Its phenomenological basics and constitutive elements are detailed, and a qualitative analysis is provided. Within this common framework, two first-order mathematical models, along with related numerical solution techniques, are derived. The models are oriented to specific real world applications: a one-dimensional model of crowd-structure interaction in footbridges and a two-dimensional model of pedestrian flow in an underground station with several obstacles and exits. The noticeable heterogeneity of the applications demonstrates the significance of the physical framework and its versatility in addressing different engineering problems. The results of the simulations point out the key role played by the physiological and psychological features of human perception on the overall crowd dynamics.

  20. Effective Thermal Conductivity Modeling of Sandstones: SVM Framework Analysis

    Science.gov (United States)

    Rostami, Alireza; Masoudi, Mohammad; Ghaderi-Ardakani, Alireza; Arabloo, Milad; Amani, Mahmood

    2016-06-01

    Among the most significant physical characteristics of porous media, the effective thermal conductivity (ETC) is used for estimating the thermal enhanced oil recovery process efficiency, hydrocarbon reservoir thermal design, and numerical simulation. This paper reports the implementation of an innovative least square support vector machine (LS-SVM) algorithm for the development of enhanced model capable of predicting the ETCs of dry sandstones. By means of several statistical parameters, the validity of the presented model was evaluated. The prediction of the developed model for determining the ETCs of dry sandstones was in excellent agreement with the reported data with a coefficient of determination value ({R}2) of 0.983 and an average absolute relative deviation of 0.35 %. Results from present research show that the proposed LS-SVM model is robust, reliable, and efficient in calculating the ETCs of sandstones.

  1. A PROBABILISTIC MODELING FRAMEWORK FOR PREDICTING POPULATION EXPOSURES TO BENZENE

    Science.gov (United States)

    The US Environmental Protection Agency (EPA) is modifying their probabilistic Stochastic Human Exposure Dose Simulation (SHEDS) model to assess aggregate exposures to air toxics. Air toxics include urban Hazardous Air Pollutants (HAPS) such as benzene from mobile sources, part...

  2. A parametric framework for modelling of bioelectrical signals

    CERN Document Server

    Mughal, Yar Muhammad

    2016-01-01

    This book examines non-invasive, electrical-based methods for disease diagnosis and assessment of heart function. In particular, a formalized signal model is proposed since this offers several advantages over methods that rely on measured data alone. By using a formalized representation, the parameters of the signal model can be easily manipulated and/or modified, thus providing mechanisms that allow researchers to reproduce and control such signals. In addition, having such a formalized signal model makes it possible to develop computer tools that can be used for manipulating and understanding how signal changes result from various heart conditions, as well as for generating input signals for experimenting with and evaluating the performance of e.g. signal extraction methods. The work focuses on bioelectrical information, particularly electrical bio-impedance (EBI). Once the EBI has been measured, the corresponding signals have to be modelled for analysis. This requires a structured approach in order to move...

  3. Model Adaptation for Prognostics in a Particle Filtering Framework

    Data.gov (United States)

    National Aeronautics and Space Administration — One of the key motivating factors for using particle filters for prognostics is the ability to include model parameters as part of the state vector to be estimated....

  4. A Framework for Structural Equation Models in General Pedigrees

    National Research Council Canada - National Science Library

    Morris, Nathan J; Elston, Robert C; Stein, Catherine M

    Background/Aims: Structural Equation Modeling (SEM) is an analysis approach that accounts for both the causal relationships between variables and the errors associated with the measurement of these variables...

  5. Integrated Modeling Framework for Anthropometry and Physiology Virtual Body

    Science.gov (United States)

    2007-06-01

    crash dummies (HYBRID III and THOR) databases, generation of geometrical models for and a state of the art instrumented thorax for blast simulations...graphics. Early humans were represented as simple performance, de-mining, ballistic protection, and other articulated bodies made of segments and...cfdrc.com 2. ATB 1998, Articulated Total Body Model Version V Website: www.cfdrc.com Users Manual: Phone: 256-726-4857 Fax: 256-726-4806 8

  6. Multi-Fidelity Framework for Modeling Combustion Instability

    Science.gov (United States)

    2016-07-27

    by integrating a reduced- order model (ROM) for combustion response into the linearized Euler equations. The ROM is developed from CFD simulations...distinguishable instability behaviors. The coupling between the ROM and the Euler equations requires two-way information transfer between the two...established by integrating a reduced-order model (ROM) for combustion response into the linearized Euler equations. The ROM is developed from CFD

  7. NSME: a framework for network worm modeling and simulation

    OpenAIRE

    Lin, Siming; Cheng, Xueqi

    2006-01-01

    Various worms have a devastating impact on Internet. Packet level network modeling and simulation has become an approach to find effective countermeasures against worm threat. However, current alternatives are not fit enough for this purpose. For instance, they mostly focus on the details of lower layers of the network so that the abstraction of application layer is very coarse. In our work, we propose a formal description of network and worm models, and define network virtualization level...

  8. A fuzzy rule based framework for noise annoyance modeling.

    Science.gov (United States)

    Botteldooren, Dick; Verkeyn, Andy; Lercher, Peter

    2003-09-01

    Predicting the effect of noise on individual people and small groups is an extremely difficult task due to the influence of a multitude of factors that vary from person to person and from context to context. Moreover, noise annoyance is inherently a vague concept. That is why, in this paper, it is argued that noise annoyance models should identify a fuzzy set of possible effects rather than seek a very accurate crisp prediction. Fuzzy rule based models seem ideal candidates for this task. This paper provides the theoretical background for building these models. Existing empirical knowledge is used to extract a few typical rules that allow making the model more specific for small groups of individuals. The resulting model is tested on two large-scale social surveys augmented with exposure simulations. The testing demonstrates how this new way of thinking about noise effect modeling can be used in practice both in management support as a "noise annoyance adviser" and in social science for testing hypotheses such as the effect of noise sensitivity or the degree of urbanization.

  9. A full annual cycle modeling framework for American black ducks

    Science.gov (United States)

    Robinson, Orin J.; McGowan, Conor; Devers, Patrick K.; Brook, Rodney W.; Huang, Min; Jones, Malcom; McAuley, Daniel G.; Zimmerman, Guthrie

    2016-01-01

    American black ducks (Anas rubripes) are a harvested, international migratory waterfowl species in eastern North America. Despite an extended period of restrictive harvest regulations, the black duck population is still below the population goal identified in the North American Waterfowl Management Plan (NAWMP). It has been hypothesized that density-dependent factors restrict population growth in the black duck population and that habitat management (increases, improvements, etc.) may be a key component of growing black duck populations and reaching the prescribed NAWMP population goal. Using banding data from 1951 to 2011 and breeding population survey data from 1990 to 2014, we developed a full annual cycle population model for the American black duck. This model uses the seven management units as set by the Black Duck Joint Venture, allows movement into and out of each unit during each season, and models survival and fecundity for each region separately. We compare model population trajectories with observed population data and abundance estimates from the breeding season counts to show the accuracy of this full annual cycle model. With this model, we then show how to simulate the effects of habitat management on the continental black duck population.

  10. Model Adaptation for Prognostics in a Particle Filtering Framework

    Directory of Open Access Journals (Sweden)

    Bhaskar Saha

    2011-01-01

    Full Text Available One of the key motivating factors for using particle filters for prognostics is the ability to include model parameters as part of the state vector to be estimated. This performs model adaptation in conjunction with state tracking, and thus, produces a tuned model that can used for long term predictions. This feature of particle filters works in most part due to the fact that they are not subject to the “curse of dimensionality”, i.e. the exponential growth of computational complexity with state dimension. However, in practice, this property holds for “well-designed” particle filters only as dimensionality increases. This paper explores the notion of wellness of design in the context of predicting remaining useful life for individual discharge cycles of Li-ion and Li-Polymer batteries. Prognostic metrics are used to analyze the tradeoff between different model designs and prediction performance. Results demonstrate how sensitivity analysis may be used to arrive at a well-designed prognostic model that can take advantage of the model adaptation properties of a particle filter.

  11. Multiscale Model of Colorectal Cancer Using the Cellular Potts Framework.

    Science.gov (United States)

    Osborne, James M

    2015-01-01

    Colorectal cancer (CRC) is one of the major causes of death in the developed world and forms a canonical example of tumorigenesis. CRC arises from a string of mutations of individual cells in the colorectal crypt, making it particularly suited for multiscale multicellular modeling, where mutations of individual cells can be clearly represented and their effects readily tracked. In this paper, we present a multicellular model of the onset of colorectal cancer, utilizing the cellular Potts model (CPM). We use the model to investigate how, through the modification of their mechanical properties, mutant cells colonize the crypt. Moreover, we study the influence of mutations on the shape of cells in the crypt, suggesting possible cell- and tissue-level indicators for identifying early-stage cancerous crypts. Crucially, we discuss the effect that the motility parameters of the model (key factors in the behavior of the CPM) have on the distribution of cells within a homeostatic crypt, resulting in an optimal parameter regime that accurately reflects biological assumptions. In summary, the key results of this paper are 1) how to couple the CPM with processes occurring on other spatial scales, using the example of the crypt to motivate suitable motility parameters; 2) modeling mutant cells with the CPM; 3) and investigating how mutations influence the shape of cells in the crypt.

  12. Design theoretic analysis of three system modeling frameworks.

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, Michael James

    2007-05-01

    This paper analyzes three simulation architectures from the context of modeling scalability to address System of System (SoS) and Complex System problems. The paper first provides an overview of the SoS problem domain and reviews past work in analyzing model and general system complexity issues. It then identifies and explores the issues of vertical and horizontal integration as well as coupling and hierarchical decomposition as the system characteristics and metrics against which the tools are evaluated. In addition, it applies Nam Suh's Axiomatic Design theory as a construct for understanding coupling and its relationship to system feasibility. Next it describes the application of MATLAB, Swarm, and Umbra (three modeling and simulation approaches) to modeling swarms of Unmanned Flying Vehicle (UAV) agents in relation to the chosen characteristics and metrics. Finally, it draws general conclusions for analyzing model architectures that go beyond those analyzed. In particular, it identifies decomposition along phenomena of interaction and modular system composition as enabling features for modeling large heterogeneous complex systems.

  13. The effect of MMF on the post-operative infections after renal transplantation%骁悉对肾移植术后感染的影响

    Institute of Scientific and Technical Information of China (English)

    唐礼功; 潘铁军; 谢森; 沈国球; 文瀚东; 杨家荣

    2000-01-01

    目的:观察骁悉(MMF)对肾移植术后感染的影响。方法:将90例肾移植术后患者分为两组.1 997年以前手术的56例为硫唑嘌呤(Aza)组,免疫抑制剂为环孢素A(CsA)加Aza加泼尼松;1998~1999年1月手术的34例为MMF组,免疫抑制剂为CsA加MMF加泼尼松。Aza组CsA起始用量为6 mg/(kg·d-1),MMF组为5mg/(kg·d-1),以后根据血药浓度进行调整。结果:90例肾移植患者术后总的感染率为17.8%,其中Aza组为21.4%(12/56),2例死亡;MMF组为11.8%(4/34),无死亡病例。两者之间感染率差异有显著性意义(P<0.05)。结论:用MMF代替Aza可以减少肾移植术后的感染率,并提高移植肾成活率。%Purpose:To investigate the effect of MMF on the postoperative infection after renal transplanta-tion. Methods: Before 1997, the CsA + Aza + prednisone were used as immunosuppresive agents postoperativelyfor 56 cases; Since 1998, drugs used for 34 cases were changed into MMF and CsA+MMF+prednisone respec-tively. The dose initially used for CsA was 65 mg/kg · d 1 in the patients of Aza group and 5 mg/kg · d 1 for theMMF group and then this dosage was regulated according to the determination of plasma level of the drug. Re-sults:The total infection rate of these 90 patients was 17.8%, 12 cases were infected in the Aza group (21.4%)and 11.8% (4 cases) in the MMF group. There were 2 patients died in the Aza group. Conclusions:The postop-erative infection rate of the patients underwent kidney transplantation might be reduced when MMF was used tosubstitute Aza during the period of postoperative management.

  14. Grinding and polishing technology by computer controlled active lap for Φ1250mmF/1.5 aspheric mirror

    Science.gov (United States)

    Fan, Bin; Zeng, Zhige; Li, Xiaojin; Chen, Qiang; Gao, Pingqi; Zhou, Jiabin; Wan, Yongjian

    2010-05-01

    For large aspheric optical elements, Computer Controlled Active Lap(CCAL) manufacturing which developed in IOE (Institute of Optics and Electronics, Chinese Academy of Science), have some advantages such as higher manufacturing efficiency, lower middle-frequency and high-frequency errors comparing the fixed lapping technology and CCOS(Computer Controlled Optical Surface) technology. A paraboloid surface of Φ1250mmF/1.5 was grinded by the active lap bonded with ceramic pills, as well as polished will pitch bonded active lap. During polishing processing a null lens was designed to test the paraboloid surface, the final testing data of RMS with ZYGO interferometer reached to 0.027λ(λ=0.6328μm).

  15. Utilisation of theoretical models and frameworks in the process of evidence synthesis.

    Science.gov (United States)

    Godfrey, Christina M; Harrison, Margaret B; Graham, Ian D; Ross-White, Amanda

    2010-01-01

    A systematic review is a comprehensive enquiry or study of secondary data sources. There is a research question, an a priori articulation of methods and a set of procedures to focus the investigation. Despite these rigorous structures to guide the review, synthesising evidence is a challenging, resource intense and time consuming process. Large volumes of information complicate not only the search functions, but also the conceptualisation of the evidence needed to create the concise and integrated results. Use of a theoretical model or framework could serve as an essential element in effectively focusing the review and designing the methods to respond to the knowledge question. This scoping review sought to confirm the value of models or frameworks used by authors working within traditional methodologies for evidence synthesis. Types of participants The focus of this review was on the context of health care.Types of intervention(s)/phenomena of interest All studies that discussed models or frameworks used specifically to address the process of synthesis were included.Types of studies Discussion, scholarship or methodology papers and reviews were included.Types of outcome All theoretical models or frameworks were described, with specific attention to the purpose of the framework for each study, and the contribution of the framework to the process of synthesis. The search strategy aimed to find both published and unpublished studies. A three-step search strategy was utilised. The databases for published material included CINAHL; Medline; EMBASE; PsycINFO; AMED; Cochrane; Biomed Central; Scirus; and Mednar. Databases for unpublished material included Dissertation Abstracts; Sociological Abstracts; Conference proceedings. The review was a focused scoping review to locate and describe the contribution of theoretical models or frameworks to the process of synthesis. The methodological quality of the discussion papers was therefore not assessed. Data was extracted from

  16. Towards uncertainty quantification and parameter estimation for Earth system models in a component-based modeling framework

    Science.gov (United States)

    Peckham, Scott D.; Kelbert, Anna; Hill, Mary C.; Hutton, Eric W. H.

    2016-05-01

    Component-based modeling frameworks make it easier for users to access, configure, couple, run and test numerical models. However, they do not typically provide tools for uncertainty quantification or data-based model verification and calibration. To better address these important issues, modeling frameworks should be integrated with existing, general-purpose toolkits for optimization, parameter estimation and uncertainty quantification. This paper identifies and then examines the key issues that must be addressed in order to make a component-based modeling framework interoperable with general-purpose packages for model analysis. As a motivating example, one of these packages, DAKOTA, is applied to a representative but nontrivial surface process problem of comparing two models for the longitudinal elevation profile of a river to observational data. Results from a new mathematical analysis of the resulting nonlinear least squares problem are given and then compared to results from several different optimization algorithms in DAKOTA.

  17. Building an Open Source Framework for Integrated Catchment Modeling

    Science.gov (United States)

    Jagers, B.; Meijers, E.; Villars, M.

    2015-12-01

    In order to develop effective strategies and associated policies for environmental management, we need to understand the dynamics of the natural system as a whole and the human role therein. This understanding is gained by comparing our mental model of the world with observations from the field. However, to properly understand the system we should look at dynamics of water, sediments, water quality, and ecology throughout the whole system from catchment to coast both at the surface and in the subsurface. Numerical models are indispensable in helping us understand the interactions of the overall system, but we need to be able to update and adjust them to improve our understanding and test our hypotheses. To support researchers around the world with this challenging task we started a few years ago with the development of a new open source modeling environment DeltaShell that integrates distributed hydrological models with 1D, 2D, and 3D hydraulic models including generic components for the tracking of sediment, water quality, and ecological quantities throughout the hydrological cycle composed of the aforementioned components. The open source approach combined with a modular approach based on open standards, which allow for easy adjustment and expansion as demands and knowledge grow, provides an ideal starting point for addressing challenging integrated environmental questions.

  18. Implementation of a PETN failure model using ARIA's general chemistry framework

    Energy Technology Data Exchange (ETDEWEB)

    Hobbs, Michael L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-01-01

    We previously developed a PETN thermal decomposition model that accurately predicts thermal ignition and detonator failure [1]. This model was originally developed for CALORE [2] and required several complex user subroutines. Recently, a simplified version of the PETN decomposition model was implemented into ARIA [3] using a general chemistry framework without need for user subroutines. Detonator failure was also predicted with this new model using ENCORE. The model was simplified by 1) basing the model on moles rather than mass, 2) simplifying the thermal conductivity model, and 3) implementing ARIA’s new phase change model. This memo briefly describes the model, implementation, and validation.

  19. A Flexible Atmospheric Modeling Framework for the CESM

    Energy Technology Data Exchange (ETDEWEB)

    Randall, David [Colorado State University; Heikes, Ross [Colorado State University; Konor, Celal [Colorado State University

    2014-11-12

    We have created two global dynamical cores based on the unified system of equations and Z-grid staggering on an icosahedral grid, which are collectively called UZIM (Unified Z-grid Icosahedral Model). The z-coordinate version (UZIM-height) can be run in hydrostatic and nonhydrostatic modes. The sigma-coordinate version (UZIM-sigma) runs in only hydrostatic mode. The super-parameterization has been included as a physics option in both models. The UZIM versions with the super-parameterization are called SUZI. With SUZI-height, we have completed aquaplanet runs. With SUZI-sigma, we are making aquaplanet runs and realistic climate simulations. SUZI-sigma includes realistic topography and a SiB3 model to parameterize the land-surface processes.

  20. A CONCEPTUAL FRAMEWORK FOR SUSTAINABLE POULTRY SUPPLY CHAIN MODEL

    Directory of Open Access Journals (Sweden)

    Mohammad SHAMSUDDOHA

    2013-12-01

    Full Text Available Now a day, sustainable supply chain is the crucially considerable matter for future focused industries. As a result, attention in supply chain management has increasingly amplified since the 1980s when firms discovered its benefits of mutual relationships within and beyond their own organization. This is why, concern researchers are trying hard to develop new theory or model which might help the corporate sector for achieving sustainability in their supply chains. This kind of reflection can be seen by the number of papers published and in particular by journal since 1980. The objectives of this paper are twofold. First, it offers a literature review on sustainable supply chain management taking papers published in last three decades. Second, it offers a conceptual sustainable supply chain process model in light of triple bottom line theory. The model has been developed by taking in-depth interview of an entrepreneur from a Poultry case industry in Bangladesh.

  1. A Framework for Modelling Connective Tissue Changes in VIIP Syndrome

    Science.gov (United States)

    Ethier, C. R.; Best, L.; Gleason, R.; Mulugeta, L.; Myers, J. G.; Nelson, E. S.; Samuels, B. C.

    2014-01-01

    Insertion of astronauts into microgravity induces a cascade of physiological adaptations, notably including a cephalad fluid shift. Longer-duration flights carry an increased risk of developing Visual Impairment and Intracranial Pressure (VIIP) syndrome, a spectrum of ophthalmic changes including posterior globe flattening, choroidal folds, distension of the optic nerve sheath, kinking of the optic nerve and potentially permanent degradation of visual function. The slow onset of changes in VIIP, their chronic nature, and the similarity of certain clinical features of VIIP to ophthalmic findings in patients with raised intracranial pressure strongly suggest that: (i) biomechanical factors play a role in VIIP, and (ii) connective tissue remodeling must be accounted for if we wish to understand the pathology of VIIP. Our goal is to elucidate the pathophysiology of VIIP and suggest countermeasures based on biomechanical modeling of ocular tissues, suitably informed by experimental data, and followed by validation and verification. We specifically seek to understand the quasi-homeostatic state that evolves over weeks to months in space, during which ocular tissue remodeling occurs. This effort is informed by three bodies of work: (i) modeling of cephalad fluid shifts; (ii) modeling of ophthalmic tissue biomechanics in glaucoma; and (iii) modeling of connective tissue changes in response to biomechanical loading.

  2. Understanding organizational congruence: formal model and simulation framework.

    NARCIS (Netherlands)

    Dignum, M.V.; Dignum, F.P.M.

    2008-01-01

    Despite a large number of studies, the effect of organizational structure on the performance and the individual cognition of its members is still not well understood. Our research aims at developing tools and formalisms to model organizations and evaluate their performance under different circumstan

  3. An Active Lattice Model in a Bayesian Framework

    DEFF Research Database (Denmark)

    Carstensen, Jens Michael

    1996-01-01

    by penalizing deviations in alignment and lattice node distance. The Markov random field represents prior knowledge about the lattice structure, and through an observation model that incorporates the visual appearance of the nodes, we can simulate realizations from the posterior distribution. A maximum...

  4. A Framework for Non-Gaussian Signal Modeling and Estimation

    Science.gov (United States)

    1999-06-01

    the minimum entropy estimator," Trabajos de Estadistica , vol. 19, pp. 55-65, 1968. XI_ ILlllgl_____l)___11-_11^· -^_X II- _ -- _ _ . III·III...Nonparametric Function Estimation, Modeling, and Simulation. Philadelphia: Society for Industrial and Applied Mathematics, 1990. [200] D. M. Titterington

  5. Levine's Conservation Model: A Framework for Advanced Gerontology Nursing Practice.

    Science.gov (United States)

    Abumaria, Ibrahim Mahmoud; Hastings-Tolsma, Marie; Sakraida, Teresa J

    2015-01-01

    Growing numbers of older adults place increased demands on already burdened healthcare systems. The cost of managing chronic illnesses mandates greater emphasis on management and prevention. This article explores the adaptation of Levine's Conservation Model as a structure for providing care to the older adult by the adult-gerontology primary care nurse practitioner (AGNP). The AGNP role, designed to provide quality care to adult and older adult populations, offers the opportunity to not only manage health care of the elderly, but to also advocate, lead in collaborative care efforts, conduct advanced planning, and manage and negotiate health delivery systems. The use of nursing models can foster the design of effective interventions that promote health of the older adult, particularly in the long-term care environment. Levine's Conservation Model provides a useful structure for older adult care in the long-term care setting. As an ideal care manager, the AGNP would be well served to consider use of the model to guide advanced nursing practice. Recommendations for clinical practice, research, and health policy. © 2014 Wiley Periodicals, Inc.

  6. Spectral element modelling of floating bodies in a Boussinesq framework

    DEFF Research Database (Denmark)

    Engsig-Karup, Allan Peter; Eskilsson, Claes; Ricchiuto, Mario

    The wave energy sector relies heavily on the use of linear hydrodynamic models for the assessment of motions, loads and power production. The linear codes are computationally efficient and produce good results if applied within their application window. However, recent studies using two-phase VOF...

  7. A Framework for the Modelling of Biphasic Reacting Systems

    DEFF Research Database (Denmark)

    Anantpinijwatna, Amata; Sin, Gürkan; O’Connell, John P.

    2014-01-01

    Biphasic reacting systems have a broad application range from organic reactions in pharmaceutical and agro-bio industries to CO 2 capture. However, mathematical modelling of biphasic reacting systems is a formidable challenge due to many phenomena underlying the process such as chemical equilibri...... systems: a PTC-based reaction system and pseudo-PTC system....

  8. An Empirical Generative Framework for Computational Modeling of Language Acquisition

    Science.gov (United States)

    Waterfall, Heidi R.; Sandbank, Ben; Onnis, Luca; Edelman, Shimon

    2010-01-01

    This paper reports progress in developing a computer model of language acquisition in the form of (1) a generative grammar that is (2) algorithmically learnable from realistic corpus data, (3) viable in its large-scale quantitative performance and (4) psychologically real. First, we describe new algorithmic methods for unsupervised learning of…

  9. Quasi-continuous stochastic simulation framework for flood modelling

    Science.gov (United States)

    Moustakis, Yiannis; Kossieris, Panagiotis; Tsoukalas, Ioannis; Efstratiadis, Andreas

    2017-04-01

    Typically, flood modelling in the context of everyday engineering practices is addressed through event-based deterministic tools, e.g., the well-known SCS-CN method. A major shortcoming of such approaches is the ignorance of uncertainty, which is associated with the variability of soil moisture conditions and the variability of rainfall during the storm event.In event-based modeling, the sole expression of uncertainty is the return period of the design storm, which is assumed to represent the acceptable risk of all output quantities (flood volume, peak discharge, etc.). On the other hand, the varying antecedent soil moisture conditions across the basin are represented by means of scenarios (e.g., the three AMC types by SCS),while the temporal distribution of rainfall is represented through standard deterministic patterns (e.g., the alternative blocks method). In order to address these major inconsistencies,simultaneously preserving the simplicity and parsimony of the SCS-CN method, we have developed a quasi-continuous stochastic simulation approach, comprising the following steps: (1) generation of synthetic daily rainfall time series; (2) update of potential maximum soil moisture retention, on the basis of accumulated five-day rainfall; (3) estimation of daily runoff through the SCS-CN formula, using as inputs the daily rainfall and the updated value of soil moisture retention;(4) selection of extreme events and application of the standard SCS-CN procedure for each specific event, on the basis of synthetic rainfall.This scheme requires the use of two stochastic modelling components, namely the CastaliaR model, for the generation of synthetic daily data, and the HyetosMinute model, for the disaggregation of daily rainfall to finer temporal scales. Outcomes of this approach are a large number of synthetic flood events, allowing for expressing the design variables in statistical terms and thus properly evaluating the flood risk.

  10. Generic framework for mining cellular automata models on protein-folding simulations.

    Science.gov (United States)

    Diaz, N; Tischer, I

    2016-05-13

    Cellular automata model identification is an important way of building simplified simulation models. In this study, we describe a generic architectural framework to ease the development process of new metaheuristic-based algorithms for cellular automata model identification in protein-folding trajectories. Our framework was developed by a methodology based on design patterns that allow an improved experience for new algorithms development. The usefulness of the proposed framework is demonstrated by the implementation of four algorithms, able to obtain extremely precise cellular automata models of the protein-folding process with a protein contact map representation. Dynamic rules obtained by the proposed approach are discussed, and future use for the new tool is outlined.

  11. Periodic model of LTA framework containing various non-tetrahedral cations

    Science.gov (United States)

    Koleżyński, A.; Mikuła, A.; Król, M.

    2016-03-01

    A simplified periodic model of Linde Type A zeolite (LTA) structure with various selected mono- and di-valent extra-framework cations was formulated. Ab initio calculations (geometry optimization and vibrational spectra calculations) using the proposed model were carried out by means of Crystal09 program. The resulting structures and simulated spectra were analyzed in detail and compared with the experimental ones. The presented results show that in most cases the proposed model agrees well with experimental results. Individual bands were assigned to respective normal modes of vibration and the changes resulting from the selective substitution of extra framework cations were described and explained.

  12. Periodic model of LTA framework containing various non-tetrahedral cations.

    Science.gov (United States)

    Koleżyński, A; Mikuła, A; Król, M

    2016-03-15

    A simplified periodic model of Linde Type A zeolite (LTA) structure with various selected mono- and di-valent extra-framework cations was formulated. Ab initio calculations (geometry optimization and vibrational spectra calculations) using the proposed model were carried out by means of Crystal09 program. The resulting structures and simulated spectra were analyzed in detail and compared with the experimental ones. The presented results show that in most cases the proposed model agrees well with experimental results. Individual bands were assigned to respective normal modes of vibration and the changes resulting from the selective substitution of extra framework cations were described and explained.

  13. A Proof-Irrelevant Model of Martin-Löf's Logical Framework

    DEFF Research Database (Denmark)

    Fridlender, Daniel

    2003-01-01

    We extend the proof-irrelevant model defined in Smith (1988) to the whole of Martin-Löf's logical framework. The main difference here is the existence of a type whose objects themselves represent types rather than proof-objects. This means that the model must now be able to distinguish between...... also show how to extend it when the logical framework itself is enlarged with inductive definitions. In doing so, a variant of Church numerals is introduced. As in Smith (1988), the model can only be defined in the absence of universes, and it is useful to obtain an elementary proof of consistency...

  14. A model-based framework for incremental scale-up of wastewater treatment processes

    DEFF Research Database (Denmark)

    Mauricio Iglesias, Miguel; Sin, Gürkan

    Scale-up is traditionally done following specific ratios or rules of thumb which do not lead to optimal results. We present a generic framework to assist in scale-up of wastewater treatment processes based on multiscale modelling, multiobjective optimisation and a validation of the model at the new...... large scale. The framework is illustrated by the scale-up of a complete autotropic nitrogen removal process. The model based multiobjective scaleup offers a promising improvement compared to the rule of thumbs based emprical scale up rules...

  15. Establishing a Numerical Modeling Framework for Hydrologic Engineering Analyses of Extreme Storm Events

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xiaodong; Hossain, Faisal; Leung, L. Ruby

    2017-08-01

    In this study a numerical modeling framework for simulating extreme storm events was established using the Weather Research and Forecasting (WRF) model. Such a framework is necessary for the derivation of engineering parameters such as probable maximum precipitation that are the cornerstone of large water management infrastructure design. Here this framework was built based on a heavy storm that occurred in Nashville (USA) in 2010, and verified using two other extreme storms. To achieve the optimal setup, several combinations of model resolutions, initial/boundary conditions (IC/BC), cloud microphysics and cumulus parameterization schemes were evaluated using multiple metrics of precipitation characteristics. The evaluation suggests that WRF is most sensitive to IC/BC option. Simulation generally benefits from finer resolutions up to 5 km. At the 15km level, NCEP2 IC/BC produces better results, while NAM IC/BC performs best at the 5km level. Recommended model configuration from this study is: NAM or NCEP2 IC/BC (depending on data availability), 15km or 15km-5km nested grids, Morrison microphysics and Kain-Fritsch cumulus schemes. Validation of the optimal framework suggests that these options are good starting choices for modeling extreme events similar to the test cases. This optimal framework is proposed in response to emerging engineering demands of extreme storm events forecasting and analyses for design, operations and risk assessment of large water infrastructures.

  16. A review of the quantification and communication of uncertainty associated with geological framework models

    Science.gov (United States)

    Mathers, Steve; Lark, Murray

    2015-04-01

    Digital Geological Framework Models show geology in three dimensions, they can most easily be thought of as 3D geological maps. The volume of the model is divided into distinct geological units using a suitable rock classification in the same way that geological maps are. Like geological maps the models are generic and many are intended to be fit for any geoscience purpose. Over the last decade many Geological Survey Organisations (GSO's) worldwide have begun to communicate their geological understanding of the subsurface through Geological Framework Models and themed derivatives, and the traditional printed geological map has been increasingly phased out. Building Geological Framework Models entails the assembly of all the known geospatial information into a single workspace for interpretation. The calculated models are commonly displayed as either a stack of geological surfaces or boundaries (unit tops, bases, unconformities) or as solid calculated blocks of 3D geology with the unit volumes infilled in with colour or symbols. The studied volume however must be completely populated so decisions on the subsurface distribution of units must be made even where considerable uncertainty exists There is naturally uncertainty associated with any Geological Framework Model and this is composed of two main components; the uncertainty in the geospatial data used to constrain the model, and the uncertainty related to the model construction, this includes factors such as choice of modeller(s), choice of software(s), and modelling workflow. Uncertainty is the inverse of confidence, reliability or certainty, other closely related terms include risk commonly used in preference to uncertainty where financial or safety matters are presented and probability used as a statistical measure of uncertainty. We can consider uncertainty in geological framework models to be of two main types: Uncertainty in the geospatial data used to constrain the model; this differs with the distinct

  17. Application of computer-aided multi-scale modelling framework – Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Glarborg, Peter

    -aided methods provide. The key prerequisite of computer-aided product-process engineering is however the availability of models of different types, forms and application modes. The development of the models required for the systems under investigation tends to be a challenging and time-consuming task involving...... numerous steps, expert skills and different modelling tools. This motivates the development of a computer-aided modelling framework that supports the user during model development, documentation, analysis, identification, application and re-use with the goal to increase the efficiency of the modelling...... generation, optimal equation ordering, eigenvalue analysis. Once the models have been constructed and analysed the modelling framework incorporates 3 application work-flows for: identification, simulation and design. For these application work-flows different solvers that can solve a large range of different...

  18. A Computational Framework for Phase-field Modeling

    Science.gov (United States)

    2011-01-01

    twin embryo within an otherwise perfect single crystal (12). Analytical models based on free energy variations in the context of phase...transformations have been applied to describe twin nucleation (12, 13). Such approaches consider nucleation of a twin embryo of idealized geometry—an elliptical...Crystals, in preparation, 2011. 12. Christian , J. W.; Mahajan, S. Deformation Twinning. Prog. Mater. Sci. 1995, 39, 1–157. 13. Lee, J. K.; Yoo, M

  19. Framework for an asymptotically safe standard model via dynamical breaking

    Science.gov (United States)

    Abel, Steven; Sannino, Francesco

    2017-09-01

    We present a consistent embedding of the matter and gauge content of the Standard Model into an underlying asymptotically safe theory that has a well-determined interacting UV fixed point in the large color/flavor limit. The scales of symmetry breaking are determined by two mass-squared parameters with the breaking of electroweak symmetry being driven radiatively. There are no other free parameters in the theory apart from gauge couplings.

  20. A unifying kinetic framework for modeling oxidoreductase-catalyzed reactions

    OpenAIRE

    Chang, Ivan; Baldi, Pierre

    2013-01-01

    Motivation: Oxidoreductases are a fundamental class of enzymes responsible for the catalysis of oxidation–reduction reactions, crucial in most bioenergetic metabolic pathways. From their common root in the ancient prebiotic environment, oxidoreductases have evolved into diverse and elaborate protein structures with specific kinetic properties and mechanisms adapted to their individual functional roles and environmental conditions. While accurate kinetic modeling of oxidoreductases is thus imp...

  1. USER CONTEXT MODELS : A FRAMEWORK TO EASE SOFTWARE FORMAL VERIFICATIONS

    OpenAIRE

    2010-01-01

    This article is accepted to appear in ICEIS 2010 proceedings; International audience; Several works emphasize the difficulties of software verification applied to embedded systems. In past years, formal verification techniques and tools were widely developed and used by the research community. However, the use of formal verification at industrial scale remains difficult, expensive and requires lot of time. This is due to the size and the complexity of manipulated models, but also, to the impo...

  2. Introducing the Core Probability Framework and Discrete-Element Core Probability Model for efficient stochastic macroscopic modelling

    NARCIS (Netherlands)

    Calvert, S.C.; Taale, H.; Hoogendoorn, S.P.

    2014-01-01

    In this contribution the Core Probability Framework (CPF) is introduced with the application of the Discrete-Element Core Probability Model (DE-CPM) as a new DNL for dynamic macroscopic modelling of stochastic traffic flow. The model is demonstrated for validation in a test case and for computationa

  3. Using the Bifocal Modeling Framework to Resolve "Discrepant Events" between Physical Experiments and Virtual Models in Biology

    Science.gov (United States)

    Blikstein, Paulo; Fuhrmann, Tamar; Salehi, Shima

    2016-01-01

    In this paper, we investigate an approach to supporting students' learning in science through a combination of physical experimentation and virtual modeling. We present a study that utilizes a scientific inquiry framework, which we call "bifocal modeling," to link student-designed experiments and computer models in real time. In this…

  4. Computational fluid dynamics framework for aerodynamic model assessment

    Science.gov (United States)

    Vallespin, D.; Badcock, K. J.; Da Ronch, A.; White, M. D.; Perfect, P.; Ghoreyshi, M.

    2012-07-01

    This paper reviews the work carried out at the University of Liverpool to assess the use of CFD methods for aircraft flight dynamics applications. Three test cases are discussed in the paper, namely, the Standard Dynamic Model, the Ranger 2000 jet trainer and the Stability and Control Unmanned Combat Air Vehicle. For each of these, a tabular aerodynamic model based on CFD predictions is generated along with validation against wind tunnel experiments and flight test measurements. The main purpose of the paper is to assess the validity of the tables of aerodynamic data for the force and moment prediction of realistic aircraft manoeuvres. This is done by generating a manoeuvre based on the tables of aerodynamic data, and then replaying the motion through a time-accurate computational fluid dynamics calculation. The resulting forces and moments from these simulations were compared with predictions from the tables. As the latter are based on a set of steady-state predictions, the comparisons showed perfect agreement for slow manoeuvres. As manoeuvres became more aggressive some disagreement was seen, particularly during periods of large rates of change in attitudes. Finally, the Ranger 2000 model was used on a flight simulator.

  5. Modelling diagnosis in physical therapy: a blackboard framework and models of experts and novices.

    Science.gov (United States)

    James, G A

    2007-03-01

    The primary objective of this study was to explore clinical reasoning in physical therapy and to highlight the similarities and differences by modelling the diagnostic phase of clinical reasoning. An experimental design comparing expert and novice physical therapists was utilized. Concurrent verbal protocols detailing the clinical reasoning about standardized case material were elicited. A framework for modelling diagnosis was specified and provided the parameters for analysis. The diagnostic utterances were classified as cues or hypotheses and the knowledge utilized was identified. The experts recruited significantly more knowledge than the novices (p = 0.01) and used more cues (p < 0.01). Their diagnoses were more accurate when compared to the original diagnosis. This difference between the experts and novices was reflected in the differences shown in the models (p < 0.01). The differences between these subjects focused upon the knowledge recruitment, which impacted on the accuracy of the diagnosis. The novices' inaccurate or non-existent diagnoses led to poor quality of treatment prescription. Modelling proved to be a useful way of representing these differences.

  6. Crops in silico: A community wide multi-scale computational modeling framework of plant canopies

    Science.gov (United States)

    Srinivasan, V.; Christensen, A.; Borkiewic, K.; Yiwen, X.; Ellis, A.; Panneerselvam, B.; Kannan, K.; Shrivastava, S.; Cox, D.; Hart, J.; Marshall-Colon, A.; Long, S.

    2016-12-01

    Current crop models predict a looming gap between supply and demand for primary foodstuffs over the next 100 years. While significant yield increases were achieved in major food crops during the early years of the green revolution, the current rates of yield increases are insufficient to meet future projected food demand. Furthermore, with projected reduction in arable land, decrease in water availability, and increasing impacts of climate change on future food production, innovative technologies are required to sustainably improve crop yield. To meet these challenges, we are developing Crops in silico (Cis), a biologically informed, multi-scale, computational modeling framework that can facilitate whole plant simulations of crop systems. The Cis framework is capable of linking models of gene networks, protein synthesis, metabolic pathways, physiology, growth, and development in order to investigate crop response to different climate scenarios and resource constraints. This modeling framework will provide the mechanistic details to generate testable hypotheses toward accelerating directed breeding and engineering efforts to increase future food security. A primary objective for building such a framework is to create synergy among an inter-connected community of biologists and modelers to create a realistic virtual plant. This framework advantageously casts the detailed mechanistic understanding of individual plant processes across various scales in a common scalable framework that makes use of current advances in high performance and parallel computing. We are currently designing a user friendly interface that will make this tool equally accessible to biologists and computer scientists. Critically, this framework will provide the community with much needed tools for guiding future crop breeding and engineering, understanding the emergent implications of discoveries at the molecular level for whole plant behavior, and improved prediction of plant and ecosystem

  7. Developing the multi-level functioning interface framework for DER models

    DEFF Research Database (Denmark)

    Han, Xue; Bindner, Henrik W.; You, Shi

    2013-01-01

    The paper summarises several modelling applications of distributed energy resources (DERs) for various purposes, and describes the related operational issues regarding the complexity of the future distribution grid. Furthermore, a multi-level functioning interface framework is proposed for DER mo....... The information mapping for photovoltaic panel (PV) modelling is also provided as an example....

  8. A general simulation model developing process based on five-object framework

    Institute of Scientific and Technical Information of China (English)

    胡安斌; 伞冶; 陈建明; 陈永强

    2003-01-01

    Different paradigms that relate verification and validation to the simulation model have different development process. A simulation model developing process based on Five-Object Framework (FOF) is discussed in this paper. An example is given to demonstrate the applications of the proposed method.

  9. A modeling framework for characterizing near-road air pollutant concentration at community scales

    Science.gov (United States)

    In this study, we combine information from transportation network, traffic emissions, and dispersion model to develop a framework to inform exposure estimates for traffic-related air pollutants (TRAPs) with a high spatial resolution. A Research LINE source dispersion model (R-LIN...

  10. The Dimensions of Social Justice Model: Transforming Traditional Group Work into a Socially Just Framework

    Science.gov (United States)

    Ratts, Manivong J.; Anthony, Loni; Santos, KristiAnna Nicole T.

    2010-01-01

    Social justice is a complex and abstract concept that can be difficult to discuss and integrate within group work. To address this concern, this article introduces readers to the Dimensions of Social Justice Model. The model provides group leaders with a conceptual framework for understanding the degree to which social justice is integrated within…

  11. Support of the Generic Framework programme : calibration of groundwater flow models

    NARCIS (Netherlands)

    Stroet, Chris C.B.M. te; Minnema, Benny

    2003-01-01

    This report is to support the “Generic Framework programme” which consists of a series of projects to create a standard in the modelling processes that are used in water management issues. The topic of support is the field of model calibration. TNO-NITG is elaborating the calibration of groundwater

  12. A system-level multiprocessor system-on-chip modeling framework

    DEFF Research Database (Denmark)

    Virk, Kashif Munir; Madsen, Jan

    2004-01-01

    We present a system-level modeling framework to model system-on-chips (SoC) consisting of heterogeneous multiprocessors and network-on-chip communication structures in order to enable the developers of today's SoC designs to take advantage of the flexibility and scalability of network-on-chip...

  13. A framework to a mass dimension one fermionic sigma model

    CERN Document Server

    Rogerio, R J Bueno; Pereira, S H; da Rocha, Roldao

    2016-01-01

    In this paper a mass dimension one fermionic sigma model, realized by the eigenspinors of the charge conjugation operator with dual helicity (Elko spinors), is developed. Such spinors are chosen as a specific realization of mass dimension one spinors, wherein the non-commutative fermionic feature is ruled by torsion. Moreover, we analyse Elko spinors as a source of matter in a background in expansion. Moreover, we analyse Elko spinors as a source of matter in a background in expansion and we have found that such kind of mass dimension one fermions can serve not only as dark matter but they also induce an effective cosmological constant.

  14. A Framework for Conceptual Modeling of Geographic Data Quality

    DEFF Research Database (Denmark)

    Friis-Christensen, Anders; Christensen, J.V.; Jensen, Christian Søndergaard

    2004-01-01

    Sustained advances in wireless communications, geo-positioning, and consumer electronics pave the way to a kind of location-based service that relies on the tracking of the continuously changing positions of an entire population of service users. This type of service is characterized by large...... determined by how "good" the data is, as different applications of geographic data require different qualities of the data are met. Such qualities concern the object level as well as the attribute level of the data. This paper presents a systematic and integrated approach to the conceptual modeling...

  15. A new fit-for-purpose model testing framework: Decision Crash Tests

    Science.gov (United States)

    Tolson, Bryan; Craig, James

    2016-04-01

    Decision-makers in water resources are often burdened with selecting appropriate multi-million dollar strategies to mitigate the impacts of climate or land use change. Unfortunately, the suitability of existing hydrologic simulation models to accurately inform decision-making is in doubt because the testing procedures used to evaluate model utility (i.e., model validation) are insufficient. For example, many authors have identified that a good standard framework for model testing called the Klemes Crash Tests (KCTs), which are the classic model validation procedures from Klemeš (1986) that Andréassian et al. (2009) rename as KCTs, have yet to become common practice in hydrology. Furthermore, Andréassian et al. (2009) claim that the progression of hydrological science requires widespread use of KCT and the development of new crash tests. Existing simulation (not forecasting) model testing procedures such as KCTs look backwards (checking for consistency between simulations and past observations) rather than forwards (explicitly assessing if the model is likely to support future decisions). We propose a fundamentally different, forward-looking, decision-oriented hydrologic model testing framework based upon the concept of fit-for-purpose model testing that we call Decision Crash Tests or DCTs. Key DCT elements are i) the model purpose (i.e., decision the model is meant to support) must be identified so that model outputs can be mapped to management decisions ii) the framework evaluates not just the selected hydrologic model but the entire suite of model-building decisions associated with model discretization, calibration etc. The framework is constructed to directly and quantitatively evaluate model suitability. The DCT framework is applied to a model building case study on the Grand River in Ontario, Canada. A hypothetical binary decision scenario is analysed (upgrade or not upgrade the existing flood control structure) under two different sets of model building

  16. Clinical Interdisciplinary Collaboration Models and Frameworks From Similarities to Differences: A Systematic Review

    Science.gov (United States)

    Mahdizadeh, Mousa; Heydari, Abbas; Moonaghi, Hossien Karimi

    2015-01-01

    Introduction: So far, various models of interdisciplinary collaboration in clinical nursing have been presented, however, yet a comprehensive model is not available. The purpose of this study is to review the evidences that had presented model or framework with qualitative approach about interdisciplinary collaboration in clinical nursing. Methods: All the articles and theses published from 1990 to 10 June 2014 which in both English and Persian models or frameworks of clinicians had presented model or framework of clinical collaboration were searched using databases of Proquest, Scopus, pub Med, Science Direct, and Iranian databases of Sid, Magiran, and Iranmedex. In this review, for published articles and theses, keywords according with MESH such as nurse-physician relations, care team, collaboration, interdisciplinary relations and their Persian equivalents were used. Results: In this study contexts, processes and outcomes of interdisciplinary collaboration as findings were extracted. One of the major components affecting on collaboration that most of the models had emphasized was background of collaboration. Most of studies suggested that the outcome of collaboration were improved care, doctors and nurses’ satisfaction, controlling costs, reducing clinical errors and patient’s safety. Conclusion: Models and frameworks had different structures, backgrounds, and conditions, but the outcomes were similar. Organizational structure, culture and social factors are important aspects of clinical collaboration. So it is necessary to improve the quality and effectiveness of clinical collaboration these factors to be considered. PMID:26153158

  17. A Physics-Informed Machine Learning Framework for RANS-based Predictive Turbulence Modeling

    Science.gov (United States)

    Xiao, Heng; Wu, Jinlong; Wang, Jianxun; Ling, Julia

    2016-11-01

    Numerical models based on the Reynolds-averaged Navier-Stokes (RANS) equations are widely used in turbulent flow simulations in support of engineering design and optimization. In these models, turbulence modeling introduces significant uncertainties in the predictions. In light of the decades-long stagnation encountered by the traditional approach of turbulence model development, data-driven methods have been proposed as a promising alternative. We will present a data-driven, physics-informed machine-learning framework for predictive turbulence modeling based on RANS models. The framework consists of three components: (1) prediction of discrepancies in RANS modeled Reynolds stresses based on machine learning algorithms, (2) propagation of improved Reynolds stresses to quantities of interests with a modified RANS solver, and (3) quantitative, a priori assessment of predictive confidence based on distance metrics in the mean flow feature space. Merits of the proposed framework are demonstrated in a class of flows featuring massive separations. Significant improvements over the baseline RANS predictions are observed. The favorable results suggest that the proposed framework is a promising path toward RANS-based predictive turbulence in the era of big data. (SAND2016-7435 A).

  18. A Mobility and Traffic Generation Framework for Modeling and Simulating Ad Hoc Communication Networks

    Directory of Open Access Journals (Sweden)

    Chris Barrett

    2004-01-01

    Full Text Available We present a generic mobility and traffic generation framework that can be incorporated into a tool for modeling and simulating large scale ad~hoc networks. Three components of this framework, namely a mobility data generator (MDG, a graph structure generator (GSG and an occlusion modification tool (OMT allow a variety of mobility models to be incorporated into the tool. The MDG module generates positions of transceivers at specified time instants. The GSG module constructs the graph corresponding to the ad hoc network from the mobility data provided by MDG. The OMT module modifies the connectivity of the graph produced by GSG to allow for occlusion effects. With two other modules, namely an activity data generator (ADG which generates packet transmission activities for transceivers and a packet activity simulator (PAS which simulates the movement and interaction of packets among the transceivers, the framework allows the modeling and simulation of ad hoc communication networks. The design of the framework allows a user to incorporate various realistic parameters crucial in the simulation. We illustrate the utility of our framework through a comparative study of three mobility models. Two of these are synthetic models (random waypoint and exponentially correlated mobility proposed in the literature. The third model is based on an urban population mobility modeling tool (TRANSIMS developed at the Los Alamos National Laboratory. This tool is capable of providing comprehensive information about the demographics, mobility and interactions of members of a large urban population. A comparison of these models is carried out by computing a variety of parameters associated with the graph structures generated by the models. There has recently been interest in the structural properties of graphs that arise in real world systems. We examine two aspects of this for the graphs created by the mobility models: change associated with power control (range of

  19. A modeling framework for investment planning in interdependent infrastructures in multi-hazard environments.

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Nathanael J. K.; Gearhart, Jared Lee; Jones, Dean A.; Nozick, Linda Karen; Prince, Michael

    2013-09-01

    Currently, much of protection planning is conducted separately for each infrastructure and hazard. Limited funding requires a balance of expenditures between terrorism and natural hazards based on potential impacts. This report documents the results of a Laboratory Directed Research & Development (LDRD) project that created a modeling framework for investment planning in interdependent infrastructures focused on multiple hazards, including terrorism. To develop this framework, three modeling elements were integrated: natural hazards, terrorism, and interdependent infrastructures. For natural hazards, a methodology was created for specifying events consistent with regional hazards. For terrorism, we modeled the terrorists actions based on assumptions regarding their knowledge, goals, and target identification strategy. For infrastructures, we focused on predicting post-event performance due to specific terrorist attacks and natural hazard events, tempered by appropriate infrastructure investments. We demonstrate the utility of this framework with various examples, including protection of electric power, roadway, and hospital networks.

  20. Towards a Common Framework for the Identification of Landforms on Terrain Models

    Directory of Open Access Journals (Sweden)

    Eric Guilbert

    2017-01-01

    Full Text Available A landform is a physical feature of the terrain with its own recognisable shape. Its definition is often qualitative and inherently vague. Hence, landforms are difficult to formalise in a logical model that can be implemented. We propose for that purpose a framework where these qualitative and vague definitions are transformed successively during different phases to yield an implementable data structure. Our main consideration is that landforms are characterised by salient elements as perceived by users. Hence, a common prototype based on an object-oriented approach is defined that shall apply to all landforms. This framework shall facilitate the definition of conceptual models for other landforms and relies on the use of ontology design patterns to express common elements and structures. The model is illustrated on examples from the literature, showing that existing works undertaken separately can be developed under a common framework.

  1. Model-based Computer Aided Framework for Design of Process Monitoring and Analysis Systems

    DEFF Research Database (Denmark)

    Singh, Ravendra; Gernaey, Krist; Gani, Rafiqul

    2009-01-01

    -aided framework including the methods and tools through which the design of monitoring and analysis systems for product quality control can be generated, analyzed and/or validated, has been developed. Two important supporting tools developed as part of the framework are a knowledge base and a model library...... subject to the maintenance constraints of the desired product quality. The application of the model-based framework is highlighted through a case study involving the operation of a fermentation process.......In the manufacturing industry, for example, the pharmaceutical industry, a thorough understanding of the process is necessary in addition to a properly designed monitoring and analysis system (PAT system) to consistently obtain the desired end-product properties. A model-based computer...

  2. Modeling Complex Biological Flows in Multi-Scale Systems using the APDEC Framework

    Energy Technology Data Exchange (ETDEWEB)

    Trebotich, D

    2006-06-24

    We have developed advanced numerical algorithms to model biological fluids in multiscale flow environments using the software framework developed under the SciDAC APDEC ISIC. The foundation of our computational effort is an approach for modeling DNA-laden fluids as ''bead-rod'' polymers whose dynamics are fully coupled to an incompressible viscous solvent. The method is capable of modeling short range forces and interactions between particles using soft potentials and rigid constraints. Our methods are based on higher-order finite difference methods in complex geometry with adaptivity, leveraging algorithms and solvers in the APDEC Framework. Our Cartesian grid embedded boundary approach to incompressible viscous flow in irregular geometries has also been interfaced to a fast and accurate level-sets method within the APDEC Framework for extracting surfaces from volume renderings of medical image data and used to simulate cardio-vascular and pulmonary flows in critical anatomies.

  3. A Framework of Environmental Modelling and Information Sharing for Urban Air Pollution Control and Management

    Institute of Scientific and Technical Information of China (English)

    LIU Gang-jun; FU Er-jiang; WANG Yun-jia; ZHANG Ke-fei; HAN Bao-ping; ARROWSMITH Colin

    2007-01-01

    More effective environmental pollution control and management are needed due to the increasing environmental impacts from a range of human activities and the growing public demands for a better living environment. Urban air pollution is a serious environmental issue that poses adverse impacts on the health of people and the environment in most metropolitan areas. In this paper, we propose a geoinformatics augmented framework of environmental modelling and information sharing for supporting effective urban air pollution control and management. This framework is outlined in terms of its key components and processes including: 1) an integrated, adaptive network of sensors for environmental monitoring; 2) a set of distributed, interoperable databases for data management; 3) a set of intelligent, robust algorithms and models for environmental modelling; 4) a set of flexible, efficient user interfaces for data access and information sharing; and 5) a reliable, high capacity, high performance computing and communication infrastructure for integrating and supporting other framework components and processes.

  4. Designing A Framework To Design A Business Model For The 'Bottom Of The Pyramid' Population

    Directory of Open Access Journals (Sweden)

    Ver Loren van Themaat, Tanye

    2013-11-01

    Full Text Available This article presents a framework for developing and designing a business model to target the bottom of the pyramid (BoP population. Using blue ocean strategy and business model literature, integrated with research on the BoP, the framework offers a systematic approach for organisations to analyse and understand all aspects of the BoP and their environment, and then design a business model that minimises the risk of failure and fulfils the core requirements of the BoP. A case study on Capitec Bank demonstrates how the framework can be applied to the real world. The case study shows the practical examples that Capitec uses to target the BoP successfully, and the logic behind these actions. Further validation was done through interviews with experts in the relevant fields used in this study.

  5. A Bayesian modelling framework for tornado occurrences in North America.

    Science.gov (United States)

    Cheng, Vincent Y S; Arhonditsis, George B; Sills, David M L; Gough, William A; Auld, Heather

    2015-03-25

    Tornadoes represent one of nature's most hazardous phenomena that have been responsible for significant destruction and devastating fatalities. Here we present a Bayesian modelling approach for elucidating the spatiotemporal patterns of tornado activity in North America. Our analysis shows a significant increase in the Canadian Prairies and the Northern Great Plains during the summer, indicating a clear transition of tornado activity from the United States to Canada. The linkage between monthly-averaged atmospheric variables and likelihood of tornado events is characterized by distinct seasonality; the convective available potential energy is the predominant factor in the summer; vertical wind shear appears to have a strong signature primarily in the winter and secondarily in the summer; and storm relative environmental helicity is most influential in the spring. The present probabilistic mapping can be used to draw inference on the likelihood of tornado occurrence in any location in North America within a selected time period of the year.

  6. A Monte Carlo Simulation Framework for Testing Cosmological Models

    Directory of Open Access Journals (Sweden)

    Heymann Y.

    2014-10-01

    Full Text Available We tested alternative cosmologies using Monte Carlo simulations based on the sam- pling method of the zCosmos galactic survey. The survey encompasses a collection of observable galaxies with respective redshifts that have been obtained for a given spec- troscopic area of the sky. Using a cosmological model, we can convert the redshifts into light-travel times and, by slicing the survey into small redshift buckets, compute a curve of galactic density over time. Because foreground galaxies obstruct the images of more distant galaxies, we simulated the theoretical galactic density curve using an average galactic radius. By comparing the galactic density curves of the simulations with that of the survey, we could assess the cosmologies. We applied the test to the expanding-universe cosmology of de Sitter and to a dichotomous cosmology.

  7. Large geospatial images discovery: metadata model and technological framework

    Directory of Open Access Journals (Sweden)

    Lukáš Brůha

    2015-12-01

    Full Text Available The advancements in geospatial web technology triggered efforts for disclosure of valuable resources of historical collections. This paper focuses on the role of spatial data infrastructures (SDI in such efforts. The work describes the interplay between SDI technologies and potential use cases in libraries such as cartographic heritage. The metadata model is introduced to link up the sources from these two distinct fields. To enhance the data search capabilities, the work focuses on the representation of the content-based metadata of raster images, which is the crucial prerequisite to target the search in a more effective way. The architecture of the prototype system for automatic raster data processing, storage, analysis and distribution is introduced. The architecture responds to the characteristics of input datasets, namely to the continuous flow of very large raster data and related metadata. Proposed solutions are illustrated on the case study of cartometric analysis of digitised early maps and related metadata encoding.

  8. A climate robust integrated modelling framework for regional impact assessment of climate change

    Science.gov (United States)

    Janssen, Gijs; Bakker, Alexander; van Ek, Remco; Groot, Annemarie; Kroes, Joop; Kuiper, Marijn; Schipper, Peter; van Walsum, Paul; Wamelink, Wieger; Mol, Janet

    2013-04-01

    Decision making towards climate proofing the water management of regional catchments can benefit greatly from the availability of a climate robust integrated modelling framework, capable of a consistent assessment of climate change impacts on the various interests present in the catchments. In the Netherlands, much effort has been devoted to developing state-of-the-art regional dynamic groundwater models with a very high spatial resolution (25x25 m2). Still, these models are not completely satisfactory to decision makers because the modelling concepts do not take into account feedbacks between meteorology, vegetation/crop growth, and hydrology. This introduces uncertainties in forecasting the effects of climate change on groundwater, surface water, agricultural yields, and development of groundwater dependent terrestrial ecosystems. These uncertainties add to the uncertainties about the predictions on climate change itself. In order to create an integrated, climate robust modelling framework, we coupled existing model codes on hydrology, agriculture and nature that are currently in use at the different research institutes in the Netherlands. The modelling framework consists of the model codes MODFLOW (groundwater flow), MetaSWAP (vadose zone), WOFOST (crop growth), SMART2-SUMO2 (soil-vegetation) and NTM3 (nature valuation). MODFLOW, MetaSWAP and WOFOST are coupled online (i.e. exchange information on time step basis). Thus, changes in meteorology and CO2-concentrations affect crop growth and feedbacks between crop growth, vadose zone water movement and groundwater recharge are accounted for. The model chain WOFOST-MetaSWAP-MODFLOW generates hydrological input for the ecological prediction model combination SMART2-SUMO2-NTM3. The modelling framework was used to support the regional water management decision making process in the 267 km2 Baakse Beek-Veengoot catchment in the east of the Netherlands. Computations were performed for regionalized 30-year climate change

  9. A Fuzzy Logic Framework for Integrating Multiple Learned Models

    Energy Technology Data Exchange (ETDEWEB)

    Hartog, Bobi Kai Den [Univ. of Nebraska, Lincoln, NE (United States)

    1999-03-01

    The Artificial Intelligence field of Integrating Multiple Learned Models (IMLM) explores ways to combine results from sets of trained programs. Aroclor Interpretation is an ill-conditioned problem in which trained programs must operate in scenarios outside their training ranges because it is intractable to train them completely. Consequently, they fail in ways related to the scenarios. We developed a general-purpose IMLM solution, the Combiner, and applied it to Aroclor Interpretation. The Combiner's first step, Scenario Identification (M), learns rules from very sparse, synthetic training data consisting of results from a suite of trained programs called Methods. S1 produces fuzzy belief weights for each scenario by approximately matching the rules. The Combiner's second step, Aroclor Presence Detection (AP), classifies each of three Aroclors as present or absent in a sample. The third step, Aroclor Quantification (AQ), produces quantitative values for the concentration of each Aroclor in a sample. AP and AQ use automatically learned empirical biases for each of the Methods in each scenario. Through fuzzy logic, AP and AQ combine scenario weights, automatically learned biases for each of the Methods in each scenario, and Methods' results to determine results for a sample.

  10. A PROPOSED HYBRID AGILE FRAMEWORK MODEL FOR MOBILE APPLICATIONS DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Ammar Khader Almasri

    2016-03-01

    Full Text Available With the increasing in mobile application systems and a high competition between companies, that led to increase in the number of mobile application projects. Mobile software development is a group of process for creating software for mobile devices with limited resources like small screen, low-power. The development of mobile applications is a big challenging because of rapidly changing business requirements and technical constraints for mobile systems. So, developers faced the challenge of a dynamic environment and the Changing of mobile application requirements. Moreover, Mobile applications should adapt appropriate software development methods that act in response efficiently to these challenges. However, at the moment, there is limited knowledge about the suitability of different software practices for the development of mobile applications. According to many researchers ,Agile methodologies was found to be most suitable for mobile development projects as they are short time, require flexibility, reduces waste and time to market. Finally, in this research we are looking for a suitable process model that conforms to the requirement of mobile application, we are going to investigate agile development methods to find a way, making the development of mobile application easy and compatible with mobile device features.

  11. Modeling Framework and Results to Inform Charging Infrastructure Investments

    Energy Technology Data Exchange (ETDEWEB)

    Melaina, Marc W [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Wood, Eric W [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-01

    The plug-in electric vehicle (PEV) market is experiencing rapid growth with dozens of battery electric (BEV) and plug-in hybrid electric (PHEV) models already available and billions of dollars being invested by automotive manufacturers in the PEV space. Electric range is increasing thanks to larger and more advanced batteries and significant infrastructure investments are being made to enable higher power fast charging. Costs are falling and PEVs are becoming more competitive with conventional vehicles. Moreover, new technologies such as connectivity and automation hold the promise of enhancing the value proposition of PEVs. This presentation outlines a suite of projects funded by the U.S. Department of Energy's Vehicle Technology Office to conduct assessments of the economic value and charging infrastructure requirements of the evolving PEV market. Individual assessments include national evaluations of PEV economic value (assuming 73M PEVs on the road in 2035), national analysis of charging infrastructure requirements (with community and corridor level resolution), and case studies of PEV ownership in Columbus, OH and Massachusetts.

  12. The Roy Adaptation Model: A Theoretical Framework for Nurses Providing Care to Individuals With Anorexia Nervosa.

    Science.gov (United States)

    Jennings, Karen M

    2017-08-18

    Using a nursing theoretical framework to understand, elucidate, and propose nursing research is fundamental to knowledge development. This article presents the Roy Adaptation Model as a theoretical framework to better understand individuals with anorexia nervosa during acute treatment, and the role of nursing assessments and interventions in the promotion of weight restoration. Nursing assessments and interventions situated within the Roy Adaptation Model take into consideration how weight restoration does not occur in isolation but rather reflects an adaptive process within external and internal environments, and has the potential for more holistic care.

  13. A Framework of Multi Objectives Negotiation for Dynamic Supply Chain Model

    Science.gov (United States)

    Chai, Jia Yee; Sakaguchi, Tatsuhiko; Shirase, Keiichi

    Trends of globalization and advances in Information Technology (IT) have created opportunity in collaborative manufacturing across national borders. A dynamic supply chain utilizes these advances to enable more flexibility in business cooperation. This research proposes a concurrent decision making framework for a three echelons dynamic supply chain model. The dynamic supply chain is formed by autonomous negotiation among agents based on multi agents approach. Instead of generating negotiation aspects (such as amount, price and due date) arbitrary, this framework proposes to utilize the information available at operational level of an organization in order to generate realistic negotiation aspect. The effectiveness of the proposed model is demonstrated by various case studies.

  14. The Melanoma MAICare Framework: A Microsimulation Model for the Assessment of Individualized Cancer Care.

    Science.gov (United States)

    van der Meijde, Elisabeth; van den Eertwegh, Alfons J M; Linn, Sabine C; Meijer, Gerrit A; Fijneman, Remond J A; Coupé, Veerle M H

    2016-01-01

    Recently, new but expensive treatments have become available for metastatic melanoma. These improve survival, but in view of the limited funds available, cost-effectiveness needs to be evaluated. Most cancer cost-effectiveness models are based on the observed clinical events such as recurrence- free and overall survival. Times at which events are recorded depend not only on the effectiveness of treatment but also on the timing of examinations and the types of tests performed. Our objective was to construct a microsimulation model framework that describes the melanoma disease process using a description of underlying tumor growth as well as its interaction with diagnostics, treatments, and surveillance. The framework should allow for exploration of the impact of simultaneously altering curative treatment approaches in different phases of the disease as well as altering diagnostics. The developed framework consists of two components, namely, the disease model and the clinical management module. The disease model consists of a tumor level, describing growth and metastasis of the tumor, and a patient level, describing clinically observed states, such as recurrence and death. The clinical management module consists of the care patients receive. This module interacts with the disease process, influencing the rate of transition between tumor growth states at the tumor level and the rate of detecting a recurrence at the patient level. We describe the framework as the required input and the model output. Furthermore, we illustrate model calibration using registry data and data from the literature.

  15. A framework for scalable parameter estimation of gene circuit models using structural information

    KAUST Repository

    Kuwahara, Hiroyuki

    2013-06-21

    Motivation: Systematic and scalable parameter estimation is a key to construct complex gene regulatory models and to ultimately facilitate an integrative systems biology approach to quantitatively understand the molecular mechanisms underpinning gene regulation. Results: Here, we report a novel framework for efficient and scalable parameter estimation that focuses specifically on modeling of gene circuits. Exploiting the structure commonly found in gene circuit models, this framework decomposes a system of coupled rate equations into individual ones and efficiently integrates them separately to reconstruct the mean time evolution of the gene products. The accuracy of the parameter estimates is refined by iteratively increasing the accuracy of numerical integration using the model structure. As a case study, we applied our framework to four gene circuit models with complex dynamics based on three synthetic datasets and one time series microarray data set. We compared our framework to three state-of-the-art parameter estimation methods and found that our approach consistently generated higher quality parameter solutions efficiently. Although many general-purpose parameter estimation methods have been applied for modeling of gene circuits, our results suggest that the use of more tailored approaches to use domain-specific information may be a key to reverse engineering of complex biological systems. The Author 2013.

  16. Framework for product knowledge and product related knowledge which supports product modelling for mass customization

    DEFF Research Database (Denmark)

    Riis, Jesper; Hansen, Benjamin Loer; Hvam, Lars

    2003-01-01

    The article presents a framework for product knowledge and product related knowledge which can be used to support the product modelling process which is needed for developing IT systems. These IT systems are important tools for many companies when they aim at achieving mass customization and pers......The article presents a framework for product knowledge and product related knowledge which can be used to support the product modelling process which is needed for developing IT systems. These IT systems are important tools for many companies when they aim at achieving mass customization...... on experience from product modelling projects in several companies. Among them for example companies manufacturing electronic switchboards, spray dryer systems and air conditioning equipment. The framework is divided into three views: the product knowledge view, the life phase system view and the transformation...... process view (“the meeting”). The persons (rolls) involved in the product modelling process are for example: domain experts, change managers, model managers, project leaders, technical facilitators, process managers and software programmers. They need a framework during the product modelling process...

  17. A Physics-Based Modeling Framework for Prognostic Studies

    Science.gov (United States)

    Kulkarni, Chetan S.

    2014-01-01

    Prognostics and Health Management (PHM) methodologies have emerged as one of the key enablers for achieving efficient system level maintenance as part of a busy operations schedule, and lowering overall life cycle costs. PHM is also emerging as a high-priority issue in critical applications, where the focus is on conducting fundamental research in the field of integrated systems health management. The term diagnostics relates to the ability to detect and isolate faults or failures in a system. Prognostics on the other hand is the process of predicting health condition and remaining useful life based on current state, previous conditions and future operating conditions. PHM methods combine sensing, data collection, interpretation of environmental, operational, and performance related parameters to indicate systems health under its actual application conditions. The development of prognostics methodologies for the electronics field has become more important as more electrical systems are being used to replace traditional systems in several applications in the aeronautics, maritime, and automotive fields. The development of prognostics methods for electronics presents several challenges due to the great variety of components used in a system, a continuous development of new electronics technologies, and a general lack of understanding of how electronics fail. Similarly with electric unmanned aerial vehicles, electrichybrid cars, and commercial passenger aircraft, we are witnessing a drastic increase in the usage of batteries to power vehicles. However, for battery-powered vehicles to operate at maximum efficiency and reliability, it becomes crucial to both monitor battery health and performance and to predict end of discharge (EOD) and end of useful life (EOL) events. We develop an electrochemistry-based model of Li-ion batteries that capture the significant electrochemical processes, are computationally efficient, capture the effects of aging, and are of suitable

  18. Health behaviour models: a framework for studying adherence in children with atopic dermatitis.

    Science.gov (United States)

    Chisolm, S S; Taylor, S L; Gryzwacz, J G; O'Neill, J L; Balkrishnan, R R; Feldman, S R

    2010-04-01

    Atopic dermatitis (AD) is a common problem of childhood causing considerable distress. Effective topical treatments exist, yet poor adherence often results in poor outcomes. A framework is needed to better understand adherence behaviour. To provide a basis for this framework, we reviewed established models used to describe health behaviour. Structural elements of these models informed the development of an adherence model for AD that can be used to complement empirical AD treatment trials. Health behaviour models provide a means to describe factors that affect adherence and that can mediate the effects of different adherence interventions. Models of adherence behaviour are important for promoting better treatment outcomes for children with AD and their families. These models provide a means to identify new targets to improve adherence and a guide for refining adherence interventions.

  19. Modeling overland flow-driven erosion across a watershed DEM using the Landlab modeling framework.

    Science.gov (United States)

    Adams, J. M.; Gasparini, N. M.; Tucker, G. E.; Hobley, D. E. J.; Hutton, E. W. H.; Nudurupati, S. S.; Istanbulluoglu, E.

    2015-12-01

    Many traditional landscape evolution models assume steady-state hydrology when computing discharge, and generally route flow in a single direction, along the path of steepest descent. Previous work has demonstrated that, for larger watersheds or short-duration storms, hydrologic steady-state may not be achieved. In semiarid regions, often dominated by convective summertime storms, landscapes are likely heavily influenced by these short-duration but high-intensity periods of rainfall. To capture these geomorphically significant bursts of rain, a new overland flow method has been implemented in the Landlab modeling framework. This overland flow method routes a hydrograph across a landscape, and allows flow to travel in multiple directions out of a given grid node. This study compares traditional steady-state flow routing and incision methods to the new, hydrograph-driven overland flow and erosion model in Landlab. We propose that for short-duration, high-intensity precipitation events, steady-state, single-direction flow routing models will significantly overestimate discharge and erosion when compared with non-steady, multiple flow direction model solutions. To test this hypothesis, discharge and erosion are modeled using both steady-state and hydrograph methods. A stochastic storm generator is used to generate short-duration, high-intensity precipitation intervals, which drive modeled discharge and erosion across a watershed imported from a digital elevation model, highlighting Landlab's robust raster-gridding library and watershed modeling capabilities. For each storm event in this analysis, peak discharge at the outlet, incision rate at the outlet, as well as total discharge and erosion depth are compared between methods. Additionally, these results are organized by storm duration and intensity to understand how erosion rates scale with precipitation between both flow routing methods. Results show that in many cases traditional steady-state methods overestimate

  20. A Framework to Implement IoT Network Performance Modelling Techniques for Network Solution Selection

    Directory of Open Access Journals (Sweden)

    Declan T. Delaney

    2016-12-01

    Full Text Available No single network solution for Internet of Things (IoT networks can provide the required level of Quality of Service (QoS for all applications in all environments. This leads to an increasing number of solutions created to fit particular scenarios. Given the increasing number and complexity of solutions available, it becomes difficult for an application developer to choose the solution which is best suited for an application. This article introduces a framework which autonomously chooses the best solution for the application given the current deployed environment. The framework utilises a performance model to predict the expected performance of a particular solution in a given environment. The framework can then choose an apt solution for the application from a set of available solutions. This article presents the framework with a set of models built using data collected from simulation. The modelling technique can determine with up to 85% accuracy the solution which performs the best for a particular performance metric given a set of solutions. The article highlights the fractured and disjointed practice currently in place for examining and comparing communication solutions and aims to open a discussion on harmonising testing procedures so that different solutions can be directly compared and offers a framework to achieve this within IoT networks.

  1. Models and frameworks: a synergistic association for developing component-based applications.

    Science.gov (United States)

    Alonso, Diego; Sánchez-Ledesma, Francisco; Sánchez, Pedro; Pastor, Juan A; Álvarez, Bárbara

    2014-01-01

    The use of frameworks and components has been shown to be effective in improving software productivity and quality. However, the results in terms of reuse and standardization show a dearth of portability either of designs or of component-based implementations. This paper, which is based on the model driven software development paradigm, presents an approach that separates the description of component-based applications from their possible implementations for different platforms. This separation is supported by automatic integration of the code obtained from the input models into frameworks implemented using object-oriented technology. Thus, the approach combines the benefits of modeling applications from a higher level of abstraction than objects, with the higher levels of code reuse provided by frameworks. In order to illustrate the benefits of the proposed approach, two representative case studies that use both an existing framework and an ad hoc framework, are described. Finally, our approach is compared with other alternatives in terms of the cost of software development.

  2. Implementation of EUnetHTA core Model® in Lombardia: the VTS framework.

    Science.gov (United States)

    Radaelli, Giovanni; Lettieri, Emanuele; Masella, Cristina; Merlino, Luca; Strada, Alberto; Tringali, Michele

    2014-01-01

    This study describes the health technology assessment (HTA) framework introduced by Regione Lombardia to regulate the introduction of new technologies. The study outlines the process and dimensions adopted to prioritize, assess and appraise the requests of new technologies. The HTA framework incorporates and adapts elements from the EUnetHTA Core Model and the EVIDEM framework. It includes dimensions, topics, and issues provided by EUnetHTA Core Model to collect data and process the assessment. Decision making is instead supported by the criteria and Multi-Criteria Decision Analysis technique from the EVIDEM consortium. The HTA framework moves along three process stages: (i) prioritization of requests, (ii) assessment of prioritized technology, (iii) appraisal of technology in support of decision making. Requests received by Regione Lombardia are first prioritized according to their relevance along eight dimensions (e.g., costs, efficiency and efficacy, organizational impact, safety). Evidence about the impacts of the prioritized technologies is then collected following the issues and topics provided by EUnetHTA Core Model. Finally, the Multi-Criteria Decision Analysis technique is used to appraise the novel technology and support Regione Lombardia decision making. The VTS (Valutazione delle Tecnologie Sanitarie) framework has been successfully implemented at the end of 2011. From its inception, twenty-six technologies have been processed.

  3. A Framework to Implement IoT Network Performance Modelling Techniques for Network Solution Selection.

    Science.gov (United States)

    Delaney, Declan T; O'Hare, Gregory M P

    2016-12-01

    No single network solution for Internet of Things (IoT) networks can provide the required level of Quality of Service (QoS) for all applications in all environments. This leads to an increasing number of solutions created to fit particular scenarios. Given the increasing number and complexity of solutions available, it becomes difficult for an application developer to choose the solution which is best suited for an application. This article introduces a framework which autonomously chooses the best solution for the application given the current deployed environment. The framework utilises a performance model to predict the expected performance of a particular solution in a given environment. The framework can then choose an apt solution for the application from a set of available solutions. This article presents the framework with a set of models built using data collected from simulation. The modelling technique can determine with up to 85% accuracy the solution which performs the best for a particular performance metric given a set of solutions. The article highlights the fractured and disjointed practice currently in place for examining and comparing communication solutions and aims to open a discussion on harmonising testing procedures so that different solutions can be directly compared and offers a framework to achieve this within IoT networks.

  4. A Framework to Implement IoT Network Performance Modelling Techniques for Network Solution Selection †

    Science.gov (United States)

    Delaney, Declan T.; O’Hare, Gregory M. P.

    2016-01-01

    No single network solution for Internet of Things (IoT) networks can provide the required level of Quality of Service (QoS) for all applications in all environments. This leads to an increasing number of solutions created to fit particular scenarios. Given the increasing number and complexity of solutions available, it becomes difficult for an application developer to choose the solution which is best suited for an application. This article introduces a framework which autonomously chooses the best solution for the application given the current deployed environment. The framework utilises a performance model to predict the expected performance of a particular solution in a given environment. The framework can then choose an apt solution for the application from a set of available solutions. This article presents the framework with a set of models built using data collected from simulation. The modelling technique can determine with up to 85% accuracy the solution which performs the best for a particular performance metric given a set of solutions. The article highlights the fractured and disjointed practice currently in place for examining and comparing communication solutions and aims to open a discussion on harmonising testing procedures so that different solutions can be directly compared and offers a framework to achieve this within IoT networks. PMID:27916929

  5. Trusted autonomic service cooperation model and application development framework

    Institute of Scientific and Technical Information of China (English)

    GAO Ji; L(U) HeXing; GUO Hang; ZHANG Fan; CHENG Yu; FU ChaoYang; WANG CunHao

    2009-01-01

    To achieve the dynamical on-requirement self-organization and self-evolution of virtual organizations (Vos) by autonomic service cooperation Is an excellent approach for developing assembled serviceoriented application software systems in the Internet computing environment.However,this approach,due to the fact that the autonomic individual behaviors are difficult to be predicted and controlled,encounters the "trust" crisis of cooperation effect.In order to solve the above crisis,this paper proposes a model of Norm-Governed and Policy-Driven autonomic service cooperation (NGPD).The key idea of NGPD Is to constrain and govern the cooperation behaviors and their evolutions of autonomic Individuals by formulating systematic standards of social structures and the coupling norms of coop eration behaviors,and thereby the cooperation behaviors (I.e.behaviors for providing and requiring services) of autonomic individuals and the cooperation effect can be controlled,predicted,and then become trusted.Furthermore,NGPD provides the "macro-micro" link mode to support the operation level implementation of macro-government and creates the policy-driven self-management mechanism for Individual behaviors to achieve the mapping from the macro-government to the micro-behaviors.Thus,the effect of the macro-government can be exerted to autonomic individuals so that they can exhibit the Intellect for conforming to service contracts and cooperation behavior norms,but still keep high autonomy again.Along with the settlement of this "trust" crisis,NGPD can overcome the limitation introduced by non-autonomic service cooperation,and thus make the autonomy and change-response ability of service cooperation exhibit the advantages of robustness and intelligence which cannot be reached by traditional service cooperation techniques.Furthermore,NGPD also establishes the solid foundation for developing the norm-driven and contract-ensured self-organization of hierarchical cooperation and the

  6. Efficient Control of Nonlinear Noise-Corrupted Systems Using a Novel Model Predictive Control Framework

    OpenAIRE

    Weissel, Florian; Huber, Marco F.; Hanebeck, Uwe D.

    2007-01-01

    Model identification and measurement acquisition is always to some degree uncertain. Therefore, a framework for Nonlinear Model Predictive Control (NMPC) is proposed that explicitly considers the noise influence on nonlinear dynamic systems with continuous state spaces and a finite set of control inputs in order to significantly increase the control quality. Integral parts of NMPC are the prediction of system states over a finite horizon as well as the problem specific modeling of reward func...

  7. A general discrete-time modeling framework for animal movement using multistate random walks

    OpenAIRE

    McClintock, B.T.; King, R; Thomas, L.; Matthiopoulos, J.; McConnell, B.J.; Morales, J.M.

    2012-01-01

    Recent developments in animal tracking technology have permitted the collection of detailed data on the movement paths of individuals from many species. However, analysis methods for these data have not developed at a similar pace, largely due to a lack of suitable candidate models, coupled with the technical difficulties of fitting such models to data. To facilitate a general modeling framework, we propose that complex movement paths can be conceived as a series of movement strategies among ...

  8. A framework to assess the realism of model structures using hydrological signatures

    Directory of Open Access Journals (Sweden)

    T. Euser

    2012-11-01

    Full Text Available The use of flexible hydrological model structures for hypothesis testing requires an objective and diagnostic method to identify whether a rainfall-runoff model structure is suitable for a certain catchment. To determine if a model structure is realistic, i.e. if it captures the relevant runoff processes, both performance and consistency are important. Performance describes the ability of a model structure to mimic a specific part of the hydrological behaviour in a specific catchment. This can be assessed based on evaluation criteria, such as the goodness of fit of specific hydrological signatures obtained from hydrological data. Consistency describes the ability of a model structure to adequately reproduce several hydrological signatures simultaneously, while using the same set of parameter values. In this paper we describe and demonstrate a new evaluation Framework for Assessing the Realism of Model structures (FARM. The evaluation framework tests for both performance and consistency using a principal component analysis on a range of evaluation criteria, all emphasizing different hydrological behaviour. The utility of this evaluation framework is demonstrated in a case study of two small headwater catchments (Maimai, New Zealand and Wollefsbach, Luxembourg. Eight different hydrological signatures and eleven model structures have been used for this study. The results suggest that some model structures may reveal the same degree of performance for selected evaluation criteria, while showing differences in consistency. The results also show that some model structures have a higher performance and consistency than others. The principal component analysis in combination with several hydrological signatures is shown to be useful to visualize the performance and consistency of a model structure for the study catchments. With this framework performance and consistency can be tested to identify which model structures suit a catchment better than other

  9. A Bayesian posterior predictive framework for weighting ensemble regional climate models

    Science.gov (United States)

    Fan, Yanan; Olson, Roman; Evans, Jason P.

    2017-06-01

    We present a novel Bayesian statistical approach to computing model weights in climate change projection ensembles in order to create probabilistic projections. The weight of each climate model is obtained by weighting the current day observed data under the posterior distribution admitted under competing climate models. We use a linear model to describe the model output and observations. The approach accounts for uncertainty in model bias, trend and internal variability, including error in the observations used. Our framework is general, requires very little problem-specific input, and works well with default priors. We carry out cross-validation checks that confirm that the method produces the correct coverage.

  10. Frameworks for change in healthcare organisations: a formative evaluation of the NHS Change Model.

    Science.gov (United States)

    Martin, Graham P; Sutton, Elizabeth; Willars, Janet; Dixon-Woods, Mary

    2013-08-01

    Organisational change in complex healthcare systems is a multifaceted process. The English National Health Service recently introduced a 'Change Model' that seeks to offer an evidence-based framework for guiding change. We report findings from a formative evaluation of the NHS Change Model and make recommendations for those developing the Model and its users. The evaluation involved 28 interviews with managers and clinicians making use of the Change Model in relation to a variety of projects. Interviews were fully transcribed and were analysed using an approach based on the Framework method. Participants saw the Change Model as valuable and practically useful. Fidelity to core principles of the Model was variable: participants often altered the Model, especially when using it to orchestrate the work of others. In challenging organisational contexts, the Change Model was sometimes used to delegitimise opposition rather than identify shared purpose among different interest groups. Those guiding change may benefit from frameworks, guidance and toolkits to structure and inform their planning and activities. Participants' experiences suggested the Change Model has much potential. Further work on its design and on supporting materials may optimise the approach, but its utility rests in particular on organisational cultures that support faithful application. © The Author(s) 2013 Reprints and permissions:]br]sagepub.co.uk/journalsPermissions.nav.

  11. Predicting the resilience and recovery of aquatic systems: A framework for model evolution within environmental observatories

    Science.gov (United States)

    Hipsey, Matthew R.; Hamilton, David P.; Hanson, Paul C.; Carey, Cayelan C.; Coletti, Janaine Z.; Read, Jordan S.; Ibelings, Bas W.; Valesini, Fiona J.; Brookes, Justin D.

    2015-09-01

    Maintaining the health of aquatic systems is an essential component of sustainable catchment management, however, degradation of water quality and aquatic habitat continues to challenge scientists and policy-makers. To support management and restoration efforts aquatic system models are required that are able to capture the often complex trajectories that these systems display in response to multiple stressors. This paper explores the abilities and limitations of current model approaches in meeting this challenge, and outlines a strategy based on integration of flexible model libraries and data from observation networks, within a learning framework, as a means to improve the accuracy and scope of model predictions. The framework is comprised of a data assimilation component that utilizes diverse data streams from sensor networks, and a second component whereby model structural evolution can occur once the model is assessed against theoretically relevant metrics of system function. Given the scale and transdisciplinary nature of the prediction challenge, network science initiatives are identified as a means to develop and integrate diverse model libraries and workflows, and to obtain consensus on diagnostic approaches to model assessment that can guide model adaptation. We outline how such a framework can help us explore the theory of how aquatic systems respond to change by bridging bottom-up and top-down lines of enquiry, and, in doing so, also advance the role of prediction in aquatic ecosystem management.

  12. A conceptual framework to design a dimensional model based on the HL7 Clinical Document Architecture.

    Science.gov (United States)

    Pecoraro, Fabrizio; Luzi, Daniela; Ricci, Fabrizio L

    2014-01-01

    This paper proposes a conceptual framework to design a dimensional model based on the HL7 Clinical Document Architecture (CDA) standard. The adoption of this framework can represent a possible solution to facilitate the integration of heterogeneous information systems in a clinical data warehouse. This can simplify the Extract, Transform and Load (ETL) procedures that are considered the most time-consuming and expensive part of the data warehouse development process. The paper describes the main activities to be carried out to design the dimensional model outlining the main advantages in the application of the proposed framework. The feasibility of our approach is also demonstrated providing a case study to define clinical indicators for quality assessment.

  13. The universal fuzzy Logical framework of neural circuits and its application in modeling primary visual cortex

    Institute of Scientific and Technical Information of China (English)

    HU Hong; LI Su; WANG YunJiu; QI XiangLin; SHI ZhongZhi

    2008-01-01

    Analytical study of large-scale nonlinear neural circuits is a difficult task. Here we analyze the function of neural systems by probing the fuzzy logical framework of the neural cells' dynamical equations. Al-though there is a close relation between the theories of fuzzy logical systems and neural systems and many papers investigate this subject, most investigations focus on finding new functions of neural systems by hybridizing fuzzy logical and neural system. In this paper, the fuzzy logical framework of neural cells is used to understand the nonlinear dynamic attributes of a common neural system by abstracting the fuzzy logical framework of a neural cell. Our analysis enables the educated design of network models for classes of computation. As an example, a recurrent network model of the primary visual cortex has been built and tested using this approach.

  14. The universal fuzzy logical framework of neural circuits and its application in modeling primary visual cortex

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Analytical study of large-scale nonlinear neural circuits is a difficult task. Here we analyze the function of neural systems by probing the fuzzy logical framework of the neural cells’ dynamical equations. Al- though there is a close relation between the theories of fuzzy logical systems and neural systems and many papers investigate this subject, most investigations focus on finding new functions of neural systems by hybridizing fuzzy logical and neural system. In this paper, the fuzzy logical framework of neural cells is used to understand the nonlinear dynamic attributes of a common neural system by abstracting the fuzzy logical framework of a neural cell. Our analysis enables the educated design of network models for classes of computation. As an example, a recurrent network model of the primary visual cortex has been built and tested using this approach.

  15. A structured continuum modelling framework for martensitic transformation and reorientation in shape memory materials.

    Science.gov (United States)

    Bernardini, Davide; Pence, Thomas J

    2016-04-28

    Models for shape memory material behaviour can be posed in the framework of a structured continuum theory. We study such a framework in which a scalar phase fraction field and a tensor field of martensite reorientation describe the material microstructure, in the context of finite strains. Gradients of the microstructural descriptors naturally enter the formulation and offer the possibility to describe and resolve phase transformation localizations. The constitutive theory is thoroughly described by a single free energy function in conjunction with a path-dependent dissipation function. Balance laws in the form of differential equations are obtained and contain both bulk and surface terms, the latter in terms of microstreses. A natural constraint on the tensor field for martensite reorientation gives rise to reactive fields in these balance laws. Conditions ensuring objectivity as well as the relation of this framework to that provided by currently used models for shape memory alloy behaviour are discussed.

  16. Simulation-based Modeling Frameworks for Networked Multi-processor System-on-Chip

    DEFF Research Database (Denmark)

    Mahadevan, Shankar

    2006-01-01

    This thesis deals with modeling aspects of multi-processor system-on-chip (MpSoC) design affected by the on-chip interconnect, also called the Network-on-Chip (NoC), at various levels of abstraction. To begin with, we undertook a comprehensive survey of research and design practices of networked Mp......SoC. The survey presents the challenges of modeling and performance analysis of the hardware and the software components used in such devices. These challenges are further exasperated in a mixed abstraction workspace, which is typical of complex MpSoC design environment. We provide two simulation-based frameworks...... and the RIPE frameworks allows easy incorporation of IP cores from either frameworks, into a new instance of the design. This could pave the way for seamless design evaluation from system-level to cycletrue abstraction in future component-based MpSoC design practice....

  17. The universal fuzzy logical framework of neural circuits and its application in modeling primary visual cortex.

    Science.gov (United States)

    Hu, Hong; Li, Su; Wang, YunJiu; Qi, XiangLin; Shi, ZhongZhi

    2008-10-01

    Analytical study of large-scale nonlinear neural circuits is a difficult task. Here we analyze the function of neural systems by probing the fuzzy logical framework of the neural cells' dynamical equations. Although there is a close relation between the theories of fuzzy logical systems and neural systems and many papers investigate this subject, most investigations focus on finding new functions of neural systems by hybridizing fuzzy logical and neural system. In this paper, the fuzzy logical framework of neural cells is used to understand the nonlinear dynamic attributes of a common neural system by abstracting the fuzzy logical framework of a neural cell. Our analysis enables the educated design of network models for classes of computation. As an example, a recurrent network model of the primary visual cortex has been built and tested using this approach.

  18. Simulation-optimization framework for multi-site multi-season hybrid stochastic streamflow modeling

    Science.gov (United States)

    Srivastav, Roshan; Srinivasan, K.; Sudheer, K. P.

    2016-11-01

    A simulation-optimization (S-O) framework is developed for the hybrid stochastic modeling of multi-site multi-season streamflows. The multi-objective optimization model formulated is the driver and the multi-site, multi-season hybrid matched block bootstrap model (MHMABB) is the simulation engine within this framework. The multi-site multi-season simulation model is the extension of the existing single-site multi-season simulation model. A robust and efficient evolutionary search based technique, namely, non-dominated sorting based genetic algorithm (NSGA - II) is employed as the solution technique for the multi-objective optimization within the S-O framework. The objective functions employed are related to the preservation of the multi-site critical deficit run sum and the constraints introduced are concerned with the hybrid model parameter space, and the preservation of certain statistics (such as inter-annual dependence and/or skewness of aggregated annual flows). The efficacy of the proposed S-O framework is brought out through a case example from the Colorado River basin. The proposed multi-site multi-season model AMHMABB (whose parameters are obtained from the proposed S-O framework) preserves the temporal as well as the spatial statistics of the historical flows. Also, the other multi-site deficit run characteristics namely, the number of runs, the maximum run length, the mean run sum and the mean run length are well preserved by the AMHMABB model. Overall, the proposed AMHMABB model is able to show better streamflow modeling performance when compared with the simulation based SMHMABB model, plausibly due to the significant role played by: (i) the objective functions related to the preservation of multi-site critical deficit run sum; (ii) the huge hybrid model parameter space available for the evolutionary search and (iii) the constraint on the preservation of the inter-annual dependence. Split-sample validation results indicate that the AMHMABB model is

  19. a Framework for Voxel-Based Global Scale Modeling of Urban Environments

    Science.gov (United States)

    Gehrung, Joachim; Hebel, Marcus; Arens, Michael; Stilla, Uwe

    2016-10-01

    The generation of 3D city models is a very active field of research. Modeling environments as point clouds may be fast, but has disadvantages. These are easily solvable by using volumetric representations, especially when considering selective data acquisition, change detection and fast changing environments. Therefore, this paper proposes a framework for the volumetric modeling and visualization of large scale urban environments. Beside an architecture and the right mix of algorithms for the task, two compression strategies for volumetric models as well as a data quality based approach for the import of range measurements are proposed. The capabilities of the framework are shown on a mobile laser scanning dataset of the Technical University of Munich. Furthermore the loss of the compression techniques is evaluated and their memory consumption is compared to that of raw point clouds. The presented results show that generation, storage and real-time rendering of even large urban models are feasible, even with off-the-shelf hardware.

  20. A multidimensional discontinuous Galerkin modeling framework for overland flow and channel routing

    Science.gov (United States)

    West, Dustin W.; Kubatko, Ethan J.; Conroy, Colton J.; Yaufman, Mariah; Wood, Dylan

    2017-04-01

    In this paper, we present the development and application of a new multidimensional, unstructured-mesh model for simulating coupled overland/open-channel flows in the kinematic wave approximation regime. The modeling approach makes use of discontinuous Galerkin (DG) finite element spatial discretizations of variable polynomial degree p, paired with explicit Runge-Kutta time steppers, and is supported by advancements made to an automatic mesh generation tool, ADMESH +, that is used to construct constrained triangulations for channel routing. The developed modeling framework is applied to a set of four test cases, where numerical results are found to compare well with known analytic solutions, experimental data and results from another well-established (structured, finite difference) model within the area of application. The numerical results obtained demonstrate the accuracy and robustness of the developed modeling framework and highlight the potential benefits of using p (polynomial) refinement for hydrological simulations.