WorldWideScience

Sample records for modeling arterial partial

  1. Surgical procedures for a rat model of partial orthotopic liver transplantation with hepatic arterial reconstruction.

    Science.gov (United States)

    Nagai, Kazuyuki; Yagi, Shintaro; Uemoto, Shinji; Tolba, Rene H

    2013-03-07

    Orthotopic liver transplantation (OLT) in rats using a whole or partial graft is an indispensable experimental model for transplantation research, such as studies on graft preservation and ischemia-reperfusion injury, immunological responses, hemodynamics, and small-for-size syndrome. The rat OLT is among the most difficult animal models in experimental surgery and demands advanced microsurgical skills that take a long time to learn. Consequently, the use of this model has been limited. Since the reliability and reproducibility of results are key components of the experiments in which such complex animal models are used, it is essential for surgeons who are involved in rat OLT to be trained in well-standardized and sophisticated procedures for this model. While various techniques and modifications of OLT in rats have been reported since the first model was described by Lee et al. in 1973, the elimination of the hepatic arterial reconstruction and the introduction of the cuff anastomosis technique by Kamada et al. were a major advancement in this model, because they simplified the reconstruction procedures to a great degree. In the model by Kamada et al., the hepatic rearterialization was also eliminated. Since rats could survive without hepatic arterial flow after liver transplantation, there was considerable controversy over the value of hepatic arterialization. However, the physiological superiority of the arterialized model has been increasingly acknowledged, especially in terms of preserving the bile duct system and the liver integrity. In this article, we present detailed surgical procedures for a rat model of OLT with hepatic arterial reconstruction using a 50% partial graft after ex vivo liver resection. The reconstruction procedures for each vessel and the bile duct are performed by the following methods: a 7-0 polypropylene continuous suture for the supra- and infrahepatic vena cava; a cuff technique for the portal vein; and a stent technique for the

  2. Partial Splenic Artery Embolization

    Directory of Open Access Journals (Sweden)

    Gh. Shadmani

    2010-05-01

    Full Text Available Background/Objective: Hypersplenism often accompanies chronic liver disease and splenomegaly is one of the four cardinal signs of hypersplenism, the other three being cytopenia, normal or hyperplastic bone marrow and response splenectomy. Surgical splenectomy is the traditional treatment."nIn the recent years, partial splenic embolization has been widely used in patients with hypersplenism and cirrhosis.This study was conducted to assess the safety and efficacy of partial splenic embolization using PVA (poly vinyl alcohol and steel coil in the management of hypersplenism."nPatients and Methods: Between Aban 1387 and Aban 1388, ten patients with hypersplenism related hematologic abnormalities (leukopenia, thrombocytopenia, variceal hemorrhage or other sequels underwent partial splenic embolization with PVA and coil. A comparison between pre-procedure and post-procedure lab data, endoscopy and splenic volumetery was done."nResults: All patients showed dramatic improvement in platelet and leukocyte counts. Platelet and leukocyte counts remained at an appropriate level during the follow up period. In one patient after one year progressive decline in the platelet count was noted, however the values remained significantly higher than before PSE (70000 vs 15000."nAlmost all patients had problems related to post embolization syndrome. In one patient severe pain was noted that lasted nearly ten days, in the other patients, pain was less severe. No significant complication (splenic abscess, pancreatitis, portal vein thrombosis developed in this study."nConclusion: The efficacy of PSE observed in our study confirms the results of previous studies in pa-tients with hypersplenism. This safe, fast method can be used bridging therapy for cirrhotic patients waiting for liver transplantation. Hematological response is related to the extension of embolization.

  3. Partially Hidden Markov Models

    DEFF Research Database (Denmark)

    Forchhammer, Søren Otto; Rissanen, Jorma

    1996-01-01

    Partially Hidden Markov Models (PHMM) are introduced. They differ from the ordinary HMM's in that both the transition probabilities of the hidden states and the output probabilities are conditioned on past observations. As an illustration they are applied to black and white image compression wher...

  4. Partial model checking

    DEFF Research Database (Denmark)

    Andersen, Henrik Reif

    1995-01-01

    A major obstacle in applying finite-state model checking to the verification of large systems is the combinatorial explosion of the state space arising when many loosely coupled parallel processes are considered. The problem also known as the state-explosion problem has been attacked from various...... sides. This paper presents a new approach based on partial model checking where parts of the concurrent system are gradually removed while transforming the specification accordingly. When the intermediate specifications constructed in this manner can be kept small, the state-explosion problem is avoided....... Experimental results with a prototype implemented in Standard ML, shows that for Milner's Scheduler-an often used benchmark-this approach improves on the published results on binary decision diagrams and is comparable to results obtained using generalized decision diagrams. Specifications are expressed...

  5. Lateral thoracic artery perforator (LTAP) flap in partial breast reconstruction.

    Science.gov (United States)

    McCulley, Stephen J; Schaverien, Mark V; Tan, Veronique K M; Macmillan, R Douglas

    2015-05-01

    Partial breast reconstruction using pedicled perforator flaps from the thoracodorsal (TDAP) and lateral intercostal arteries (LICAP) is well described. The article introduces the lateral thoracic artery perforator (LTAP) flap as an additional valuable option from the lateral chest wall and reports clinical experience and outcomes. The anatomy of the LTAP flap is reviewed and the results of a consecutive series are reported. In a series of 75 consecutive cases of lateral chest wall perforator flaps used for reconstruction of partial breast defects, 12 (17%) were raised as pure LTAP flaps, and a further 19 (27%) as combined LTAP/LICAP flaps. The LTAP was therefore used in 44% of flaps overall. One LTAP flap (delayed case) had early venous compromise that settled spontaneously. The LTAP flap is a reliable option for partial breast reconstruction from the lateral chest wall, particularly in the immediate setting. It allows comparable flap size to be harvested compared to LICAP flaps. The LTAP flap can be raised on its own pedicle allowing greater mobilization or it can be incorporated into the more commonly used LICAP flap to augment perfusion. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  6. An experimental pilot study on controlled portal vein arterialization with an extracorporeal device in the swine model of partial liver resection and ischemia.

    Science.gov (United States)

    Nardo, B; Montalti, R; Puviani, L; Pacilè, V; Beltempo, P; Bertelli, R; Licursi, M; Pariali, M; Cianciavicchia, D

    2006-09-01

    To determine whether the physiologically oxygenated arterial blood reversed in the portal system by means of portal vein arterialization (PVA) through an extracorporeal device which we have called L.E.O2.NARDO (Liver Extracorporeal Oxygen. NARDO) is effective in treating swine with subtotal hepatectomy leading to acute liver failure (ALF). Ten swine with ALF induced by 85-90% liver resection and five minutes of ischemia-reperfusion injury were randomly divided into two groups: five animals received PVA extracorporeal treatment and five swine were not-treated (control group). Blood was withdrawn from the iliac artery and reversed in the portal venous system. An extracorporeal device was interposed between the outflow and the inflow in order to monitoring the hemodynamic parameters. Each treatment lasted 6 hours. Serum and liver samples were collected in both groups. The survival was assessed at 1 week. The PVA-extracorporeal treatment yielded beneficial effects for subtotal hepatectomy-induced ALF swine with decreased serum ammonia, transaminases and total bilirubin as compared with the untreated group. INR recovered rapidly in the PVA-extracorporeal group remaining significantly lower than in untreated animals. The 7-day survival of PVA-extracorporeal group swine was significantly higher than that of untreated animals, with a statistically significant difference (pportal system through the extracorporeal device is easily applicable, efficacious, safe and may represent a novel approach for ALF swine induced by subtotal liver resection.

  7. [Experimental study of partial arterialization of the portal vein on the dearterialized liver].

    Science.gov (United States)

    Maeda, K

    1991-06-01

    The influence of hepatic arterial obstruction on the hepatic circulation and tissue metabolism was studied between animals with and without partial arterialization of the portal vein. Mongrel dogs were divided into these groups: a group in which the collaterals to the liver were obstructed and the hepatic artery was dissected (hepatic artery ligated group); two groups in which an extracorporeal femoral artery-portal vein shunt was produced, and blood was sent by a Biopump at a rate of 100 or 200 ml/min (100 ml/min and 200 ml/min portal arterialized groups). The hepatic artery ligated group showed CO2 accumulation and acidosis in hepatic venous blood, reduction of oxygen supply, increase of oxygen consumption and marked increase of GOT and GPT. In the portal arterialized groups, sufficient oxygenation of portal blood was noted, and the oxygen demand and supply and tissue metabolism were kept approximately normal. The optimum flow rate for partial arterialization of the portal vein seemed to be 100 ml/min. At the flow rate of 200 ml/min, the original portal blood was reduced, leading to portal hypertension and increase of GOT and GPT. These results indicate that partial arterialization of the portal vein effectively preserves the liver function during the operation and in the early period after dissection of the hepatic artery.

  8. Planning with Partial Preference Models

    CERN Document Server

    Nguyen, Tuan; Gerevini, Alfonso; Serina, Ivan; Srivastava, Biplav; Kambhampati, Subbarao

    2011-01-01

    Current work in planning with preferences assume that the user's preference models are completely specified and aim to search for a single solution plan. In many real-world planning scenarios, however, the user probably cannot provide any information about her desired plans, or in some cases can only express partial preferences. In such situations, the planner has to present not only one but a set of plans to the user, with the hope that some of them are similar to the plan she prefers. We first propose the usage of different measures to capture quality of plan sets that are suitable for such scenarios: domain-independent distance measures defined based on plan elements (actions, states, causal links) if no knowledge of the user's preferences is given, and the Integrated Convex Preference measure in case the user's partial preference is provided. We then investigate various heuristic approaches to find set of plans according to these measures, and present empirical results demonstrating the promise of our app...

  9. Partial chord diagrams and matrix models

    DEFF Research Database (Denmark)

    Andersen, Jørgen Ellegaard; Fuji, Hiroyuki; Manabe, Masahide

    spectrum. Furthermore, we consider the boundary length and point spectrum that unifies the last two types of spectra. We introduce matrix models that encode generating functions of partial chord diagrams filtered by each of these spectra. Using these matrix models, we derive partial differential equations......In this article, the enumeration of partial chord diagrams is discussed via matrix model techniques. In addition to the basic data such as the number of backbones and chords, we also consider the Euler characteristic, the backbone spectrum, the boundary point spectrum, and the boundary length...... – obtained independently by cut-and-join arguments in an earlier work – for the corresponding generating functions....

  10. A note on solutions of an equation modelling arterial deformation

    Energy Technology Data Exchange (ETDEWEB)

    Gordoa, P.R. [Area de Matematica Aplicada, ESCET, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid (Spain)]. E-mail: pilar.gordoa@urjc.es

    2007-08-15

    The derivation of exact solutions for a partial differential equation modelling arterial deformation in large arteries is considered. Amongst other results, we show that, for any values of the parameters appearing in the equation, solutions in terms of the first Painleve transcendent can be obtained. This is in spite of the non-integrability of the equation. We also establish a connection, via an approximation of the equation under study by the Korteweg-de Vries equation, with the second Painleve equation. Our results thus serve to further demonstrate the wide applicability and importance of the Painleve equations.

  11. Numerical modeling of partial discharges parameters

    Directory of Open Access Journals (Sweden)

    Kartalović Nenad M.

    2016-01-01

    Full Text Available In recent testing of the partial discharges or the use for the diagnosis of insulation condition of high voltage generators, transformers, cables and high voltage equipment develops rapidly. It is a result of the development of electronics, as well as, the development of knowledge about the processes of partial discharges. The aim of this paper is to contribute the better understanding of this phenomenon of partial discharges by consideration of the relevant physical processes in isolation materials and isolation systems. Prebreakdown considers specific processes, and development processes at the local level and their impact on specific isolation material. This approach to the phenomenon of partial discharges needed to allow better take into account relevant discharge parameters as well as better numerical model of partial discharges.

  12. Different modalities of arterial reconstruction in hepatic retransplantation using right partial graft

    Institute of Scientific and Technical Information of China (English)

    Salvatore Gruttadauria; Fabrizio di Francesco; Marco Spada; Mariapina Milazzo; Bruno Gridelli

    2009-01-01

    Though split-liver and living-related transplantation are routinely performed, they are done almost exclusively for primary liver transplantation because of potential surgical difficulties. These difficulties are generally related to arterial revascularization, particularly if there is hepatic artery thrombosis. According to UNOS data,of the hepatic retransplantations performed between 1996 and 2007, only 8.7% were done using right or extended right grafts from deceased donors, and 14.3%using right grafts from live donors. Here we report our experience with 5 hepatic retransplantations in which right partial grafts resulting from conventional in situ splits, and one right lobe resulting from an adult-toadult living-related transplant, were successfully used with different modalities of graft arterialization.

  13. [Partial models in fixed prosthodontics].

    Science.gov (United States)

    Käyser, A F; Creugers, N H

    1996-10-01

    In general there is consensus regarding the required criteria for crown- and bridge restorations. However, the variety in methods used for their fabrication is large. Textbooks and courses tend to advocate the use of full arch impressions without supplying objective data indicating better clinical behaviour of these restorations compared with the use of quadrant impressions. This article presents advantages, disadvantages, indication and essential steps when using quadrant models.

  14. Clinical outcome of patients with familial hypercholesterolemia and coronary artery disease undergoing partial ileal bypass surgery

    Directory of Open Access Journals (Sweden)

    Jaqueline Scholz Issa

    2000-07-01

    Full Text Available Familial hypercholesterolemia is characterized by high serum levels of total cholesterol and LDL-cholesterol. It may be homozygous or heterozygous. In homozygous patients, LDL-cholesterol levels range from 500 to 1000mg/dL and coronary artery disease is precocious, usually manifesting itself between the 2nd and 3rd decades of life. The diagnosis is often made by the presence of xanthoma tuberosum and tendinous xanthomas that appear between the 1st and 2nd decades of life. The use of high doses of statins or even unusual procedures (apheresis, partial ileal bypass surgery, liver transplantation, gene therapy, or both, is necessary for increasing survival and improving quality of life, because a reduction in cholesterol levels is essential for stabilizing the coronary artery disease and reducing xanthomas. We report our experience with 3 patients with xanthomatous familial hypercholesterolemia and coronary artery disease, who underwent partial ileal bypass surgery. Their follow-up over the years (approximately 8 years showed a mean 30% reduction in total cholesterol, with a significant reduction in the xanthomas and stabilization of the coronary artery disease.

  15. Pseudoaneurysm of the renal artery following partial nephrectomy: Imaging findings and coil embolization

    Energy Technology Data Exchange (ETDEWEB)

    Cohenpour, M. [Department of Diagnostic Imaging, Assaf Harofeh Medical Center, Zerifin (Israel)], E-mail: mehrzad@bezeqint.net; Strauss, S.; Gottlieb, P.; Peer, A. [Department of Diagnostic Imaging, Assaf Harofeh Medical Center, Zerifin (Israel); Rimon, U. [Department of diagnostic imaging, Sheba Medical Center, Tel Hashomer (Israel); Stav, K. [Department of Urology, Assaf Harofeh Medical Center, Zerifin (Israel); Gayer, G. [Department of Diagnostic Imaging, Assaf Harofeh Medical Center, Zerifin (Israel)

    2007-11-15

    Aim: To present the imaging findings of five patients with renal artery pseudoaneurysm (RAP) after partial nephrectomy. Methods: Five patients (four men and one woman) with RAP as a complication of partial nephrectomy were studied. The diagnosis of RAP was established using contrast-enhanced computed tomography (CT) in three patients and renal angiography in two patients. In two cases, the diagnosis was evident on ultrasound with colour Doppler. Results: The indication for partial nephrectomy (open approach in four patients and laparoscopic in one patient) was a space-occupying lesion, which proved to be a renal cell carcinoma. All patients presented with macroscopic haematuria, 1-21 days (mean 12.2 days) after surgery. In three of patients the definitive diagnostic imaging method was contrast-enhanced CT. The arterial phase of CT showed a well-circumscribed dense collection of contrast material located within the renal parenchyma. In two other patients the initial and conclusive diagnostic imaging method was renal angiography. All patients underwent selective renal angiography with therapeutic coil embolization. The procedure failed in one patient, which necessitated nephrectomy. Conclusions: Pseudoaneurysm of the renal artery should be considered in patients presenting with macrohaematuria after nephron-sparing surgery. The diagnosis can be established using contrast-enhanced CT, ultrasound with colour Doppler, or angiography. Renal angiography with selective embolization is a safe and efficacious technique for managing the condition.

  16. Partial Differential Equations Modeling and Numerical Simulation

    CERN Document Server

    Glowinski, Roland

    2008-01-01

    This book is dedicated to Olivier Pironneau. For more than 250 years partial differential equations have been clearly the most important tool available to mankind in order to understand a large variety of phenomena, natural at first and then those originating from human activity and technological development. Mechanics, physics and their engineering applications were the first to benefit from the impact of partial differential equations on modeling and design, but a little less than a century ago the Schrödinger equation was the key opening the door to the application of partial differential equations to quantum chemistry, for small atomic and molecular systems at first, but then for systems of fast growing complexity. Mathematical modeling methods based on partial differential equations form an important part of contemporary science and are widely used in engineering and scientific applications. In this book several experts in this field present their latest results and discuss trends in the numerical analy...

  17. Partially decoupled modeling of hydraulic fracturing processes

    Energy Technology Data Exchange (ETDEWEB)

    Settari, A.; Puchyr, P.J.; Bachman, R.C. (Simtech Consulting Services, Calgary (CA))

    1990-02-01

    A new method of partial decoupling of the problem of modeling a hydraulic fracture in a reservoir is described. According to the authors this approach has significant advantages over previous methods with fully coupled or completely uncoupled models. Better accuracy can be achieved in modeling the fracture propagation, and the new system is very efficient and versatile. Virtually any reservoir model can be used for predicting postfracture productivity. Examples of single- and multiphase applications for modeling fractured wells are discussed.

  18. Partial breast reconstruction with mini superficial inferior epigastric artery and mini deep inferior epigastric perforator flaps.

    Science.gov (United States)

    Spiegel, Aldona J; Eldor, Liron

    2010-08-01

    In this study, partial breast reconstruction was undertaken after breast conservation therapy using mini abdominal free flaps on both an immediate and delayed basis.Patient demographics, oncologic status, reconstructive data, and complications were collected from medical records.Twelve patients (age range 39-60) were included in this study with a mean follow-up time of 5 years. Ten mini superficial inferior epigastric artery flaps and 2 mini deep inferior epigastric perforator flaps were used (7 immediate and 5 delayed reconstructions). No flap lost, 1 minor abdominal wound dehiscence, and no local or distant recurrences were noted. Good to excellent results were reported by 91% of the women.In properly selected patients with high motivation toward breast conservation, tailored abdominal mini-free flaps can safely and satisfactorily be implemented for the reconstruction of partial mastectomy defects. Patients should be comprehensively educated on the potential future implications of using the abdominal donor site for partial breast reconstruction.

  19. [Primary pulmonary artery sarcoma in 36-year-old women: 3-years follow-up after partial resection and radiotherapy].

    Science.gov (United States)

    Drożdż, Jarosław; Warchoł, Ewa; Fijuth, Jacek; Filipiak, Krzysztof; Spych, Michał; Maciejewski, Marek; Piestrzeniewicz, Katarzyna; Ludomir, Stafańczyk; Janaszek-Sitkowska, Hanna; Januszewicz, Andrzej; Zembala, Marian

    2013-01-01

    Intimal sarcoma of the heart and pulmonary artery is a very rare, malignant, primary tumour. The prognosis in patients with primary sarcoma of the pulmonary artery, including intimal sarcoma, is poor. We present the case and 3-years follow-up of 36-year-old woman who was successfully treated with surgical, partial resection of the tumour followed by radiotherapy.

  20. Assessment of distributed arterial network models.

    Science.gov (United States)

    Segers, P; Stergiopulos, N; Verdonck, P; Verhoeven, R

    1997-11-01

    The aim of this study is to evaluate the relative importance of elastic non-linearities, viscoelasticity and resistance vessel modelling on arterial pressure and flow wave contours computed with distributed arterial network models. The computational results of a non-linear (time-domain) and a linear (frequency-domain) mode were compared using the same geometrical configuration and identical upstream and downstream boundary conditions and mechanical properties. pressures were computed at the ascending aorta, brachial and femoral artery. In spite of the identical problem definition, computational differences were found in input impedance modulus (max. 15-20%), systolic pressure (max. 5%) and pulse pressure (max. 10%). For the brachial artery, the ratio of pulse pressure to aortic pulse pressure was practically identical for both models (3%), whereas for the femoral artery higher values are found for the linear model (+10%). The aortic/brachial pressure transfer function indicates that pressure harmonic amplification is somewhat higher in the linear model for frequencies lower than 6 Hz while the opposite is true for higher frequencies. These computational disparities were attributed to conceptual model differences, such as the treatment of geometric tapering, rather than to elastic or convective non-linearities. Compared to the effect of viscoelasticity, the discrepancy between the linear and non-linear model is of the same importance. At peripheral locations, the correct representation of terminal impedance outweight the computational differences between the linear and non-linear models.

  1. Consistent Partial Least Squares Path Modeling

    NARCIS (Netherlands)

    Dijkstra, Theo K.; Henseler, Jörg

    2015-01-01

    This paper resumes the discussion in information systems research on the use of partial least squares (PLS) path modeling and shows that the inconsistency of PLS path coefficient estimates in the case of reflective measurement can have adverse consequences for hypothesis testing. To remedy this, the

  2. Discrete Surface Modelling Using Partial Differential Equations.

    Science.gov (United States)

    Xu, Guoliang; Pan, Qing; Bajaj, Chandrajit L

    2006-02-01

    We use various nonlinear partial differential equations to efficiently solve several surface modelling problems, including surface blending, N-sided hole filling and free-form surface fitting. The nonlinear equations used include two second order flows, two fourth order flows and two sixth order flows. These nonlinear equations are discretized based on discrete differential geometry operators. The proposed approach is simple, efficient and gives very desirable results, for a range of surface models, possibly having sharp creases and corners.

  3. Giant partially thrombosed 4 th ventricular posterior inferior cerebellar artery aneurysm; microsurgical management

    Directory of Open Access Journals (Sweden)

    Forhad Hossain Chowdhury

    2014-01-01

    Full Text Available A 42-year-old woman presented with a 3-month history of progressive occipital headache, vomiting, walking difficulty, and repeated fall. She had no history of sudden and severe headache. She had positive cerebellar signs, predominantly on the right side. Computerized tomography (CT scan, CT angiogram, and magnetic resonance image (MRI of the brain showed suspected partially thrombosed giant 4 th ventricular posterior inferior cerebellar artery aneurysm. Patient developed severe hypersensitivity reaction during both CT scan and MRI after contrast injection. Though needed, digital subtraction angiogram (DSA of cerebral vessels was not done. The aneurysm was managed by microsurgical clipping of the aneurysm neck and partial excision of thrombosed aneurysm. Here, we report the details of management of these difficult giant aneurysm without DSA.

  4. Can selective arterial clamping with fluorescence imaging preserve kidney function during robotic partial nephrectomy?

    Science.gov (United States)

    McClintock, Tyler R; Bjurlin, Marc A; Wysock, James S; Borofsky, Michael S; Marien, Tracy P; Okoro, Chinonyerem; Stifelman, Michael D

    2014-08-01

    To compare renal functional outcomes in robotic partial nephrectomy (RPN) with selective arterial clamping guided by near-infrared fluorescence (NIRF) imaging to a matched cohort of patients who underwent RPN without selective arterial clamping and NIRF imaging. From April 2011 to December 2012, NIRF imaging-enhanced RPN with selective clamping was used in 42 cases. Functional outcomes of successful cases were compared with a cohort of patients, matched by tumor size, preoperative estimated glomerular filtration rate (eGFR), functional kidney status, age, sex, body mass index, and American Society of Anesthesiologists score, who underwent RPN without selective clamping and NIRF imaging. In matched-pair analysis, selective clamping with NIRF was associated with superior kidney function at discharge, as demonstrated by postoperative eGFR (78.2 vs 68.5 mL/min/1.73 m(2); P = .04), absolute reduction of eGFR (-2.5 vs -14.0 mL/min/1.73 m(2); P functional outcomes when compared with RPN without selective arterial clamping and NIRF imaging. With this effect attenuated at later follow-up, randomized prospective studies and long-term assessment of kidney-specific functional outcomes are needed to further assess the benefits of this technology. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Comparison of partial volume effects in arterial and venous contrast curves in CT brain perfusion imaging.

    Directory of Open Access Journals (Sweden)

    Alan J Riordan

    Full Text Available PURPOSE: In brain CT perfusion (CTP, the arterial contrast bolus is scaled to have the same area under the curve (AUC as the venous outflow to correct for partial volume effects (PVE. This scaling is based on the assumption that large veins are unaffected by PVE. Measurement of the internal carotid artery (ICA, usually unaffected by PVE due to its large diameter, may avoid the need for partial volume correction. The aims of this work are to examine i the assumptions behind PVE correction and ii the potential of selecting the ICA obviating correction for PVE. METHODS: The AUC of the ICA and sagittal sinus were measured in CTP datasets from 52 patients. The AUCs were determined by i using commercial CTP software based on a Gaussian curve-fitting to the time attenuation curve, and ii by simple integration of the time attenuation curve over a time interval. In addition, frames acquired up to 3 minutes after first bolus passage were used to examine the ratio of arterial and venous enhancement. The impact of selecting the ICA without PVE correction was illustrated by reporting cerebral blood volume (CBV measurements. RESULTS: In 49 of 52 patients, the AUC of the ICA was significantly larger than that of the sagittal sinus (p = 0.017. Measured after the first pass bolus, contrast enhancement remained 50% higher in the ICA just after the first pass bolus, and 30% higher 3 minutes later. CBV measurements were significantly lowered when the ICA was used without PVE correction. CONCLUSIONS: Contradicting the assumptions underlying PVE correction, contrast in the ICA was significantly higher than in the sagittal sinus, even 3 minutes after the first pass of the contrast bolus. PVE correction might lead to overestimation of CBV if the CBV is calculated using the AUC of the time attenuation curves.

  6. Estimating Arterial Partial Pressure of Carbon Dioxide in Ventilated Patients: How Valid Are Surrogate Measures?

    Science.gov (United States)

    Nassar, Boulos S; Schmidt, Gregory A

    2017-06-01

    The arterial partial pressure of carbon dioxide (PaCO2) is an important parameter in critically ill, mechanically ventilated patients. To limit invasive procedures or for more continuous monitoring of PaCO2, clinicians often rely on venous blood gases, capnography, or transcutaneous monitoring. Each of these has advantages and limitations. Central venous Pco2 allows accurate estimation of PaCO2, differing from it by an amount described by the Fick principle. As long as cardiac output is relatively normal, central venous Pco2 exceeds the arterial value by approximately 4 mm Hg. In contrast, peripheral venous Pco2 is a poor predictor of PaCO2, and we do not recommend using peripheral venous Pco2 in this manner. Capnography offers measurement of the end-tidal Pco2 (PetCO2), a value that is close to PaCO2 when the lung is healthy. It has the advantage of being noninvasive and continuously available. In mechanically ventilated patients with lung disease, however, PetCO2 often differs from PaCO2, sometimes by a large degree, often seriously underestimating the arterial value. Dependence of PetCO2 on alveolar dead space and ventilator expiratory time limits its value to predict PaCO2. When lung function or ventilator settings change, PetCO2 and PaCO2 can vary in different directions, producing further uncertainty. Transcutaneous Pco2 measurement has become practical and reliable. It is promising for judging steady state values for PaCO2 unless there is overt vasoconstriction of the skin. Moreover, it can be useful in conditions where capnography fails (high-frequency ventilation) or where arterial blood gas analysis is burdensome (clinic or home management of mechanical ventilation).

  7. Coding with partially hidden Markov models

    DEFF Research Database (Denmark)

    Forchhammer, Søren; Rissanen, J.

    1995-01-01

    Partially hidden Markov models (PHMM) are introduced. They are a variation of the hidden Markov models (HMM) combining the power of explicit conditioning on past observations and the power of using hidden states. (P)HMM may be combined with arithmetic coding for lossless data compression. A general...... 2-part coding scheme for given model order but unknown parameters based on PHMM is presented. A forward-backward reestimation of parameters with a redefined backward variable is given for these models and used for estimating the unknown parameters. Proof of convergence of this reestimation is given....... The PHMM structure and the conditions of the convergence proof allows for application of the PHMM to image coding. Relations between the PHMM and hidden Markov models (HMM) are treated. Results of coding bi-level images with the PHMM coding scheme is given. The results indicate that the PHMM can adapt...

  8. Partial differential equation models in macroeconomics.

    Science.gov (United States)

    Achdou, Yves; Buera, Francisco J; Lasry, Jean-Michel; Lions, Pierre-Louis; Moll, Benjamin

    2014-11-13

    The purpose of this article is to get mathematicians interested in studying a number of partial differential equations (PDEs) that naturally arise in macroeconomics. These PDEs come from models designed to study some of the most important questions in economics. At the same time, they are highly interesting for mathematicians because their structure is often quite difficult. We present a number of examples of such PDEs, discuss what is known about their properties, and list some open questions for future research. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  9. Partially composite two-Higgs doublet model

    Indian Academy of Sciences (India)

    Dong-Won Jung

    2007-11-01

    In the extra dimensional scenarios with gauge fields in the bulk, the Kaluza-Klein (KK) gauge bosons can induce Nambu-Jona-Lasinio (NJL) type attractive four-fermion interactions, which can break electroweak symmetry dynamically with accompanying composite Higgs fields. We consider a possibility that electroweak symmetry breaking (EWSB) is triggered by both a fundamental Higgs and a composite Higgs arising in a dynamical symmetry breaking mechanism induced by a new strong dynamics. The resulting Higgs sector is a partially composite two-Higgs doublet model with specific boundary conditions on the coupling and mass parameters originating at a compositeness scale . The phenomenology of this model is discussed including the collider phenomenology at LHC and ILC.

  10. Combat modeling with partial differential equations

    Energy Technology Data Exchange (ETDEWEB)

    Protopopescu, V.; Santoro, R.T.; Dockery, J.; Cox, R.L.; Barnes, J.M.

    1987-11-01

    A new analytic model based on coupled nonlinear partial differential equations is proposed to describe the temporal and spatial evolution of opposing forces in combat. Analytic descriptions of combat have been developed previously using relatively simpler models based on ordinary differential equations (.e.g, Lanchester's equations of combat) that capture only the global temporal variation of the forces, but not their spatial movement (advance, retreat, flanking maneuver, etc.). The rationale for analytic models and, particularly, the motivation for the present model are reviewed. A detailed description of this model in terms of the mathematical equations together with the possible and plausible military interpretation are presented. Numerical solutions of the nonlinear differential equation model for a large variety of parameters (battlefield length, initial force ratios, initial spatial distribution of forces, boundary conditions, type of interaction, etc.) are implemented. The computational methods and computer programs are described and the results are given in tabular and graphic form. Where possible, the results are compared with the predictions given by the traditional Lanchester equations. Finally, a PC program is described that uses data downloaded from the mainframe computer for rapid analysis of the various combat scenarios. 11 refs., 10 figs., 5 tabs.

  11. Non-Newtonian model study for blood flow through a tapered artery with a stenosis

    Directory of Open Access Journals (Sweden)

    Noreen Sher Akbar

    2016-03-01

    Full Text Available The blood flow through a tapered artery with a stenosis is analyzed, assuming the blood as tangent hyperbolic fluid model. The resulting nonlinear implicit system of partial differential equations is solved analytically with the help of perturbation method. The expressions for shear stress, velocity, flow rate, wall shear stress and longitudinal impedance are obtained. The variations of power law index m, Weissenberg number We, shape of stenosis n and stenosis size δ are discussed different type of tapered arteries.

  12. Parameter Estimation of Partial Differential Equation Models

    KAUST Repository

    Xun, Xiaolei

    2013-09-01

    Partial differential equation (PDE) models are commonly used to model complex dynamic systems in applied sciences such as biology and finance. The forms of these PDE models are usually proposed by experts based on their prior knowledge and understanding of the dynamic system. Parameters in PDE models often have interesting scientific interpretations, but their values are often unknown and need to be estimated from the measurements of the dynamic system in the presence of measurement errors. Most PDEs used in practice have no analytic solutions, and can only be solved with numerical methods. Currently, methods for estimating PDE parameters require repeatedly solving PDEs numerically under thousands of candidate parameter values, and thus the computational load is high. In this article, we propose two methods to estimate parameters in PDE models: a parameter cascading method and a Bayesian approach. In both methods, the underlying dynamic process modeled with the PDE model is represented via basis function expansion. For the parameter cascading method, we develop two nested levels of optimization to estimate the PDE parameters. For the Bayesian method, we develop a joint model for data and the PDE and develop a novel hierarchical model allowing us to employ Markov chain Monte Carlo (MCMC) techniques to make posterior inference. Simulation studies show that the Bayesian method and parameter cascading method are comparable, and both outperform other available methods in terms of estimation accuracy. The two methods are demonstrated by estimating parameters in a PDE model from long-range infrared light detection and ranging data. Supplementary materials for this article are available online. © 2013 American Statistical Association.

  13. Comparing the Effect of Continuous and Intermittent Irrigation Techniques on Complications of Arterial Catheter and Partial Thromboplastin Time in Patients Following Coronary Artery Bypass Grafting Surgery

    Directory of Open Access Journals (Sweden)

    Sedigheh Arta

    2017-04-01

    Full Text Available Background: Different approaches are available to irrigate the arterial catheter, such as continuous and intermittent techniques. However, there is a disagreement regarding the most appropriate method. Aim: this study aimed to compare the effect of two continuous and intermittent irrigation methods on complications of arterial catheter and partial thromboplastin time (PTT in patients with coronary artery bypass (CABG surgery. Method: This randomized clinical trial was conducted on 60 participants undergoing coronary artery bypass grafting surgery in open-heart surgery ICU at Imam Reza hospital in Mashhad, Iran, in 2016. In continuous group, the arterial catheter was continuously irrigated with heparin solution at the rate of 2cc/h, and in the intermittent group with a syringe containing 5cc heparin solution every 3 hours. In both groups, catheter was monitored and recorded every 3 hours (until 48 hours and 3 times from enrollment in terms of complications of partial thromboplastin time. Data were analyzed using SPSS version 16. Results: The findingsof independent t-test showed that the two groups are homogeneous in age (P =0.48. The result of Fisher's exact test revealed no significant difference between the two groups in terms of average incidence of complications during the first 24 hours (P=0.55 and second 24 hours (P=0.55 after catheterization. Also during the 48 hours after surgery, independent t-test results showed no statistically significant difference in partial thromboplastin time (P=0.53 between the two groups. Implications for Practice: According to the results of the research based on the lack of difference between continuous and intermittent irrigation methods up to 48 hours after catheter replacement in terms of arterial catheter complications, further long-term follow-up researches are recommended.

  14. Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices

    Directory of Open Access Journals (Sweden)

    Goldenberg Anna

    2006-06-01

    Full Text Available Abstract Background Acute alveolar hypoxia causes pulmonary vasoconstriction (HPV which serves to match lung perfusion to ventilation. The underlying mechanisms are not fully resolved yet. The major vascular segment contributing to HPV, the intra-acinar artery, is mostly located in that part of the lung that cannot be selectively reached by the presently available techniques, e.g. hemodynamic studies of isolated perfused lungs, recordings from dissected proximal arterial segments or analysis of subpleural vessels. The aim of the present study was to establish a model which allows the investigation of HPV and its underlying mechanisms in small intra-acinar arteries. Methods Intra-acinar arteries of the mouse lung were studied in 200 μm thick precision-cut lung slices (PCLS. The organisation of the muscle coat of these vessels was characterized by α-smooth muscle actin immunohistochemistry. Basic features of intra-acinar HPV were characterized, and then the impact of reactive oxygen species (ROS scavengers, inhibitors of the respiratory chain and Krebs cycle metabolites was analysed. Results Intra-acinar arteries are equipped with a discontinuous spiral of α-smooth muscle actin-immunoreactive cells. They exhibit a monophasic HPV (medium gassed with 1% O2 that started to fade after 40 min and was lost after 80 min. This HPV, but not vasoconstriction induced by the thromboxane analogue U46619, was effectively blocked by nitro blue tetrazolium and diphenyleniodonium, indicating the involvement of ROS and flavoproteins. Inhibition of mitochondrial complexes II (3-nitropropionic acid, thenoyltrifluoroacetone and III (antimycin A specifically interfered with HPV, whereas blockade of complex IV (sodium azide unspecifically inhibited both HPV and U46619-induced constriction. Succinate blocked HPV whereas fumarate had minor effects on vasoconstriction. Conclusion This study establishes the first model for investigation of basic characteristics of HPV

  15. Mathematical modelling of triple arterial stenoses.

    Science.gov (United States)

    Ang, K C; Mazumdar, J

    1995-06-01

    This paper examines the effects of triple stenoses (ie. three stenoses in series) in a reasonably large artery. The model developed is axi-symmetric and blood is assumed to be a Newtonian fluid. The governing equations are the Navier-Stokes equations and the continuity equation. These equations are solved using the Finite Element Method and the FIDAP computational fluid dynamics (C.F.D.) package. Various combinations of differing degrees of stenosis in the triplet are considered. Pressure drop profiles and streamline plots of the solutions to these models show that the effects of milder stenoses are diminished in the presence of more severe ones. Also, a pressure recovery is observed whenever a mild stenosis follows a more severe stenosis in multiply stenosed arteries.

  16. Standard model with partial gauge invariance

    Science.gov (United States)

    Chkareuli, J. L.; Kepuladze, Z.

    2012-03-01

    We argue that an exact gauge invariance may disable some generic features of the Standard Model which could otherwise manifest themselves at high energies. One of them might be related to the spontaneous Lorentz invariance violation (SLIV), which could provide an alternative dynamical approach to QED and Yang-Mills theories with photon and non-Abelian gauge fields appearing as massless Nambu-Goldstone bosons. To see some key features of the new physics expected we propose partial rather than exact gauge invariance in an extended SM framework. This principle applied, in some minimal form, to the weak hypercharge gauge field B μ and its interactions, leads to SLIV with B field components appearing as the massless Nambu-Goldstone modes, and provides a number of distinctive Lorentz breaking effects. Being naturally suppressed at low energies they may become detectable in high energy physics and astrophysics. Some of the most interesting SLIV processes are considered in significant detail.

  17. Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats

    OpenAIRE

    Masataka Hirata; Daiki Ousaka; Sadahiko Arai; Michihiro Okuyama; Suguru Tarui; Junko Kobayashi; Shingo Kasahara; Shunji Sano

    2015-01-01

    Background. Congenital heart diseases often involve chronic pressure overload of the right ventricle (RV) which is a major cause of RV dysfunction. Pulmonary artery (PA) banding has been used to produce animal models of RV dysfunction. We have devised a new and easier method of constricting the PA and compared it directly with the partial ligation method. Methods. Eight-week-old male Sprague-Dawley rats (240–260 g) were divided into three groups: sham operation, partial pulmonary artery ligat...

  18. Partial Orders and Fully Abstract Models for Concurrency

    DEFF Research Database (Denmark)

    Engberg, Uffe Henrik

    1990-01-01

    In this thesis sets of labelled partial orders are employed as fundamental mathematical entities for modelling nondeterministic and concurrent processes thereby obtaining so-called noninterleaving semantics. Based on different closures of sets of labelled partial orders, simple algebraic languages...

  19. Combined treatment of hepatocellular carcinoma with partial splenic embolization and transcatheter hepatic arterial chemoembolization

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    AIM: To prospectively evaluate the efficacy and safety of partial splenic embolization (PSE) combined with transcatheter hepatic arterial chemoembolization (TACE)in treatment of hepatocellular carcinoma (HCC).METHODS: Fifty patients suffering from primary HCC associated with hypersplenism caused by cirrhosis were randomly assigned to 2 groups: group A receiving PSE combined with TACE (n = 26) and group B receiving TACE alone (n = 24). Follow-up examinations included calculation of peripheral blood cells (leukcytes,platelets and red blood cells) and treatment-associated complications.RESULTS: Prior to treatment, there was no significant difference in sex, age, Child-Pugh grade, tumor diameter,mass pathology type and peripheral blood cell counts between the 2 groups. After treatment, leukocyte and platelet counts were significantly higher in group A during the 3-mo follow-up period (P < 0.05), but lower in group B (P < 0.05). Severe complications occurred in 3 patients (11.5%) of group A and in 19 patients (79.2%) of group B (P < 0.05), and there was no significant difference in symptoms of post-embolization syndrome,including abdominal pain, fever, mild nausea and vomiting between the 2 groups (P > 0.05).CONCLUSION: PSE combined with TACE is more effective and safe than TACE alone for patients with HCC associated with hypersplenism caused by cirrhosis.

  20. An object-oriented modelling framework for the arterial wall.

    Science.gov (United States)

    Balaguera, M I; Briceño, J C; Glazier, J A

    2010-02-01

    An object-oriented modelling framework for the arterial wall is presented. The novelty of the framework is the possibility to generate customizable artery models, taking advantage of imaging technology. In our knowledge, this is the first object-oriented modelling framework for the arterial wall. Existing models do not allow close structural mapping with arterial microstructure as in the object-oriented framework. In the implemented model, passive behaviour of the arterial wall was considered and the tunica adventitia was the objective system. As verification, a model of an arterial segment was generated. In order to simulate its deformation, a matrix structural mechanics simulator was implemented. Two simulations were conducted, one for an axial loading test and other for a pressure-volume test. Each simulation began with a sensitivity analysis in order to determinate the best parameter combination and to compare the results with analogue controls. In both cases, the simulated results closely reproduced qualitatively and quantitatively the analogue control plots.

  1. Feasibility Study of Ex Ovo Chick Chorioallantoic Artery Model for Investigating Pulsatile Variation of Arterial Geometry.

    Science.gov (United States)

    Nam, Kweon-Ho; Kim, Juho; Ra, Gicheol; Lee, Chong Hyun; Paeng, Dong-Guk

    2015-01-01

    Despite considerable research efforts on the relationship between arterial geometry and cardiovascular pathology, information is lacking on the pulsatile geometrical variation caused by arterial distensibility and cardiomotility because of the lack of suitable in vivo experimental models and the methodological difficulties in examining the arterial dynamics. We aimed to investigate the feasibility of using a chick embryo system as an experimental model for basic research on the pulsatile variation of arterial geometry. Optical microscope video images of various arterial shapes in chick chorioallantoic circulation were recorded from different locations and different embryo samples. The high optical transparency of the chorioallantoic membrane (CAM) allowed clear observation of tiny vessels and their movements. Systolic and diastolic changes in arterial geometry were visualized by detecting the wall boundaries from binary images. Several to hundreds of microns of wall displacement variations were recognized during a pulsatile cycle. The spatial maps of the wall motion harmonics and magnitude ratio of harmonic components were obtained by analyzing the temporal brightness variation at each pixel in sequential grayscale images using spectral analysis techniques. The local variations in the spectral characteristics of the arterial wall motion were reflected well in the analysis results. In addition, mapping the phase angle of the fundamental frequency identified the regional variations in the wall motion directivity and phase shift. Regional variations in wall motion phase angle and fundamental-to-second harmonic ratio were remarkable near the bifurcation area. In summary, wall motion in various arterial geometry including straight, curved and bifurcated shapes was well observed in the CAM artery model, and their local and cyclic variations could be characterized by Fourier and wavelet transforms of the acquired video images. The CAM artery model with the spectral

  2. Quadratic function between arterial partial oxygen pressure and mortality risk in sepsis patients: an interaction with simplified acute physiology score.

    Science.gov (United States)

    Zhang, Zhongheng; Ji, Xuqing

    2016-10-13

    Oxygen therapy is widely used in emergency and critical care settings, while there is little evidence on its real therapeutic effect. The study aimed to explore the impact of arterial oxygen partial pressure (PaO2) on clinical outcomes in patients with sepsis. A large clinical database was employed for the study. Subjects meeting the diagnostic criteria of sepsis were eligible for the study. All measurements of PaO2 were extracted. The primary endpoint was death from any causes during hospital stay. Survey data analysis was performed by using individual ICU admission as the primary sampling unit. Quadratic function was assumed for PaO2 and its interaction with other covariates were explored. A total of 199,125 PaO2 samples were identified for 11,002 ICU admissions. Each ICU stay comprised 18 PaO2 samples in average. The fitted multivariable model supported our hypothesis that the effect of PaO2 on mortality risk was in quadratic form. There was significant interaction between PaO2 and SAPS-I (p = 0.007). Furthermore, the main effect of PaO2 on SOFA score was nonlinear. The study shows that the effect of PaO2 on mortality risk is in quadratic function form, and there is significant interaction between PaO2 and severity of illness.

  3. Partially dynamic vehicle routing - models and algorithms

    DEFF Research Database (Denmark)

    Larsen, Allan; Madsen, Oli B.G.; Solomon, M.

    2002-01-01

    In this paper we propose a framework for dynamic routing systems based on their degree of dynamism. Next, we consider its impact on solution methodology and quality. Specifically, we introduce the Partially Dynamic Travelling Repairman Problem and describe several dynamic policies to minimize rou...

  4. Model averaging for semiparametric additive partial linear models

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    To improve the prediction accuracy of semiparametric additive partial linear models(APLM) and the coverage probability of confidence intervals of the parameters of interest,we explore a focused information criterion for model selection among ALPM after we estimate the nonparametric functions by the polynomial spline smoothing,and introduce a general model average estimator.The major advantage of the proposed procedures is that iterative backfitting implementation is avoided,which thus results in gains in computational simplicity.The resulting estimators are shown to be asymptotically normal.A simulation study and a real data analysis are presented for illustrations.

  5. Hub discovery in partial correlation graphical models

    CERN Document Server

    Hero, Alfred

    2011-01-01

    This paper treats the problem of screening a p-variate sample for strongly and multiply connected vertices in the partial correlation graph associated with the the partial correlation matrix of the sample. This problem, called hub screening, is important in many applications ranging from network security to computational biology to finance to social networks. In the area of network security, a node that becomes a hub of high correlation with neighboring nodes might signal anomalous activity such as a coordinated flooding attack. In the area of computational biology the set of hubs of a gene expression correlation graph can serve as potential targets for drug treatment to block a pathway or modulate host response. In the area of finance a hub might indicate a vulnerable financial instrument or sector whose collapse might have major repercussions on the market. In the area of social networks a hub of observed interactions between criminal suspects could be an influential ringleader. The techniques and theory pr...

  6. Estimation of an image derived input function with MR-defined carotid arteries in FDG-PET human studies using a novel partial volume correction method

    DEFF Research Database (Denmark)

    Sari, Hasan; Erlandsson, Kjell; Law, Ian

    2017-01-01

    Kinetic analysis of (18)F-fluorodeoxyglucose positron emission tomography data requires an accurate knowledge the arterial input function. The gold standard method to measure the arterial input function requires collection of arterial blood samples and is an invasive method. Measuring an image...... segmentation of the carotid arteries from MR images. The simulation study results showed that at least 92% of the true intensity could be recovered after the partial volume correction. Results from 19 subjects showed that the mean cerebral metabolic rate of glucose calculated using arterial samples and partial...... volume corrected image derived input function were 26.9 and 25.4 mg/min/100 g, respectively, for the grey matter and 7.2 and 6.7 mg/min/100 g for the white matter. No significant difference in the estimated cerebral metabolic rate of glucose values was observed between arterial samples and corrected...

  7. Computational modeling of hypertensive growth in the human carotid artery

    Science.gov (United States)

    Sáez, Pablo; Peña, Estefania; Martínez, Miguel Angel; Kuhl, Ellen

    2014-06-01

    Arterial hypertension is a chronic medical condition associated with an elevated blood pressure. Chronic arterial hypertension initiates a series of events, which are known to collectively initiate arterial wall thickening. However, the correlation between macrostructural mechanical loading, microstructural cellular changes, and macrostructural adaptation remains unclear. Here, we present a microstructurally motivated computational model for chronic arterial hypertension through smooth muscle cell growth. To model growth, we adopt a classical concept based on the multiplicative decomposition of the deformation gradient into an elastic part and a growth part. Motivated by clinical observations, we assume that the driving force for growth is the stretch sensed by the smooth muscle cells. We embed our model into a finite element framework, where growth is stored locally as an internal variable. First, to demonstrate the features of our model, we investigate the effects of hypertensive growth in a real human carotid artery. Our results agree nicely with experimental data reported in the literature both qualitatively and quantitatively.

  8. Teaching Modeling with Partial Differential Equations: Several Successful Approaches

    Science.gov (United States)

    Myers, Joseph; Trubatch, David; Winkel, Brian

    2008-01-01

    We discuss the introduction and teaching of partial differential equations (heat and wave equations) via modeling physical phenomena, using a new approach that encompasses constructing difference equations and implementing these in a spreadsheet, numerically solving the partial differential equations using the numerical differential equation…

  9. Teaching Modeling with Partial Differential Equations: Several Successful Approaches

    Science.gov (United States)

    Myers, Joseph; Trubatch, David; Winkel, Brian

    2008-01-01

    We discuss the introduction and teaching of partial differential equations (heat and wave equations) via modeling physical phenomena, using a new approach that encompasses constructing difference equations and implementing these in a spreadsheet, numerically solving the partial differential equations using the numerical differential equation…

  10. Mathematical model of carotid artery for stent placement

    Science.gov (United States)

    Rahman, Tengku Husna Tengku Abdul; Din, Ummul Khair Salma; Ahmad, Rokiah @ Rozita

    2016-11-01

    The carotid artery stenting is one of the methods used to reduce the effect of artherosclerosis which caused by the thickening of the artery wall. In most of the studies, the measure of wall elasticity, shear stress and the blood pressure through the blood flow were considered. The aim of this study is to determine the position to place the stent inside the carotid artery. A mathematical model is reconstructed to determine the suitable location of the stent in the carotid artery. Throughout the study, differences in fluid flow between a normal carotid artery wall and stenosed carotid artery wall are investigated. Since the existence of the stenosis provides a resistance in the flow, it is important to identify the right position to place the stent. The stent will be placed in the position where stenosis exists to ease the blood to flow normally. Later after the stent placement, the blood flow normally through the blood vessel.

  11. Quadratic function between arterial partial oxygen pressure and mortality risk in sepsis patients: an interaction with simplified acute physiology score

    OpenAIRE

    Zhongheng Zhang; Xuqing Ji

    2016-01-01

    Oxygen therapy is widely used in emergency and critical care settings, while there is little evidence on its real therapeutic effect. The study aimed to explore the impact of arterial oxygen partial pressure (PaO2) on clinical outcomes in patients with sepsis. A large clinical database was employed for the study. Subjects meeting the diagnostic criteria of sepsis were eligible for the study. All measurements of PaO2 were extracted. The primary endpoint was death from any causes during hospita...

  12. Study and optimization of the partial discharges in capacitor model ...

    African Journals Online (AJOL)

    model at different temperatures. Etude et ... undegased is measured and the effect of temperature was examined. The partial discharge ... discharges and show that the low temperature ..... Journal Exploring the Frontiers of Physics, Vol. 66 (1),.

  13. Partial order of frustrated Potts model

    Energy Technology Data Exchange (ETDEWEB)

    Igarashi, Ryo [CCSE, Japan Atomic Energy Agency, Higashi-Ueno, Taito, Tokyo 110-0015 (Japan); Ogata, Masao, E-mail: igarashi.ryo@jaea.go.j [Deaprtment of Physics, University of Tokyo, Hongo, Bunkyo, Tokyo 133-0033 (Japan)

    2010-01-01

    We investigate a 4-state ferromagnetic Potts model with a special type of geometrical frustration on a three dimensional diamond lattice. We find that the model undergoes unconventional phase transition; half of the spins in the system order in a two dimensional hexagonal-sheet-like structure while the remaining half of the spins stay disordered. The ordered sheets and the disordered sheets stack one after another. We obtain fairly large residual entropy using the Wang-Landau Monte Carlo simulation.

  14. Correcting partial volume artifacts of the arterial input function in quantitative cerebral perfusion MRI

    NARCIS (Netherlands)

    van Osch, MJP; Vonken, EJPA; Bakker, CJG; Viergever, MA

    2001-01-01

    To quantify cerebral perfusion with dynamic susceptibility contrast MRI (DSC-MRI), one needs to measure the arterial input function (AIF). Conventionally, one derives the contrast concentration from the DSC sequence by monitoring changes in either the amplitude or the phase signal on the assumption

  15. Partially Natural Two Higgs Doublet Models

    CERN Document Server

    Draper, Patrick; Ruderman, Joshua T

    2016-01-01

    It is possible that the electroweak scale is low due to the fine-tuning of microscopic parameters, which can result from selection effects. The experimental discovery of new light fundamental scalars other than the Standard Model Higgs boson would seem to disfavor this possibility, since generically such states imply parametrically worse fine-tuning with no compelling connection to selection effects. We discuss counterexamples where the Higgs boson is light because of fine-tuning, and a second scalar doublet is light because a discrete symmetry relates its mass to the mass of the Standard Model Higgs boson. Our examples require new vectorlike fermions at the electroweak scale, and the models possess a rich electroweak vacuum structure. The mechanism that we discuss does not protect a small CP-odd Higgs mass in split or high-scale supersymmetry-breaking scenarios of the MSSM due to an incompatibility between the discrete symmetries and holomorphy.

  16. Residual models for nonlinear partial differential equations

    Directory of Open Access Journals (Sweden)

    Garry Pantelis

    2005-11-01

    Full Text Available Residual terms that appear in nonlinear PDEs that are constructed to generate filtered representations of the variables of the fully resolved system are examined by way of a consistency condition. It is shown that certain commonly used empirical gradient models for the residuals fail the test of consistency and therefore cannot be validated as approximations in any reliable sense. An alternate method is presented for computing the residuals. These residual models are independent of free or artificial parameters and there direct link with the functional form of the system of PDEs which describe the fully resolved system are established.

  17. Bayesian mixture models for partially verified data

    DEFF Research Database (Denmark)

    Kostoulas, Polychronis; Browne, William J.; Nielsen, Søren Saxmose;

    2013-01-01

    for some individuals, in order to minimize this loss in the discriminatory power. The distribution of the continuous antibody response against MAP has been obtained for healthy, MAP-infected and MAP-infectious cows of different age groups. The overall power of the milk-ELISA to discriminate between healthy......Bayesian mixture models can be used to discriminate between the distributions of continuous test responses for different infection stages. These models are particularly useful in case of chronic infections with a long latent period, like Mycobacterium avium subsp. paratuberculosis (MAP) infection...

  18. Modeling the dynamics of partial wetting

    NARCIS (Netherlands)

    Huber, M.; Säckel, W.; Hirschler, M.; Hassanizadeh, S.M.; Nieken, U.

    2013-01-01

    The behavior of interfaces and contact lines arises from intermolecular interactions like Van der Waals forces. To consider this multi–phase behavior on the continuum scale, appropriate physical descriptions must be formulated. While the Continuum Surface Force model is well–engineered for the

  19. Modeling the dynamics of partial wetting

    NARCIS (Netherlands)

    Huber, M.; Säckel, W.; Hirschler, M.; Hassanizadeh, S.M.; Nieken, U.

    2013-01-01

    The behavior of interfaces and contact lines arises from intermolecular interactions like Van der Waals forces. To consider this multi–phase behavior on the continuum scale, appropriate physical descriptions must be formulated. While the Continuum Surface Force model is well–engineered for the descr

  20. A Partial Differential Inequality in Geological Models

    Institute of Scientific and Technical Information of China (English)

    Robert EYMARD; Thierry GALLOU(E)T

    2007-01-01

    Sedimentation and erosion processes in sedimentary basins can be modeled by a parabolic equation with a limiter on the fluxes and a constraint on the time variation. This limiter happens to satisfy a stationary scalar hyperbolic inequality, within a constraint, for which the authors prove the existence and the uniqueness of the solution. Actually, this solution is shown to be the maximal element of a convenient convex set of functions. The existence proof is obtained thanks to the use of a numerical scheme.

  1. Symmetry and partial order reduction techniques in model checking Rebeca

    NARCIS (Netherlands)

    Jaghouri, M.M.; Sirjani, M.; Mousavi, M.R.; Movaghar, A.

    2007-01-01

    Rebeca is an actor-based language with formal semantics that can be used in modeling concurrent and distributed software and protocols. In this paper, we study the application of partial order and symmetry reduction techniques to model checking dynamic Rebeca models. Finding symmetry based equivalen

  2. Partial hepatectomy hemodynamics changes: Experimental data explained by closed-loop lumped modeling.

    Science.gov (United States)

    Audebert, Chloe; Bekheit, Mohamed; Bucur, Petru; Vibert, Eric; Vignon-Clementel, Irene E

    2017-01-04

    The liver function may be degraded after partial liver ablation surgery. Adverse liver hemodynamics have been shown to be associated to liver failure. The link between these hemodynamics changes and ablation size is however poorly understood. This article proposes to explain with a closed-loop lumped model the hemodynamics changes observed during twelve surgeries in pigs. The portal venous tree is modeled with a pressure-dependent variable resistor. The variables measured, before liver ablation, are used to tune the model parameters. Then, the liver partial ablation is simulated with the model and the simulated pressures and flows are compared with post-operative measurements. Fluid infusion and blood losses occur during the surgery. The closed-loop model presented accounts for these blood volume changes. Moreover, the impact of blood volume changes and the liver lobe mass estimations on the simulated variables is studied. The typical increase of portal pressure, increase of liver pressure loss, slight decrease of portal flow and major decrease in arterial flow are quantitatively captured by the model for a 75% hepatectomy. It appears that the 75% decrease in hepatic arterial flow can be explained by the resistance increase induced by the surgery, and that no hepatic arterial buffer response (HABR) mechanism is needed to account for this change. The different post-operative states, observed in experiments, are reproduced with the proposed model. Thus, an explanation for inter-subjects post-operative variability is proposed. The presented framework can easily be adapted to other species circulations and to different pathologies for clinical hepatic applications.

  3. Influence of arterial geometry on a model for growth rate of atheromas

    Energy Technology Data Exchange (ETDEWEB)

    Gessaghi, Valeria C [Facultad de Ingenieria, Universidad Nacional de La Pampa, General Pico, La Pampa (Argentina); Raschi, Marcelo A [Facultad de Ingenieria y Ciencias Exactas y Centro de Estudios Avanzados, Universidad Argentina de la Empresa, Ciudad Autonoma de Buenos Aires (Argentina); Larreteguy, Axel E [Facultad de Ingenieria y Ciencias Exactas y Centro de Estudios Avanzados, Universidad Argentina de la Empresa, Ciudad Autonoma de Buenos Aires (Argentina); Perazzo, Carlos A [Facultad de Ingenieria y Ciencias Exactas y Naturales, Universidad de Favaloro, Ciudad Autonoma de Buenos Aires, Argentina y CONICET (Argentina)

    2007-11-15

    Atherosclerosis is a disease that affects medium and large size arteries and it can partially or totally obstruct blood flow through them. The lack of blood supply to the heart or the brain can cause an infarct or a stroke with fatal consequences or permanent effects. This disease involves the proliferation of cells and the accumulation of fat, cholesterol, cell debris, calcium and other substances in the artery wall. Such accumulation results in the formation of atherosclerotic plaques called atheromas, which may cause the obstruction of the blood flow. Cardiovascular diseases, among which atherosclerosis is the most frequent, are the first cause of death in developed countries. The published works in the subject suggest that hemodynamic forces on arterial walls have influence on the localization, initial development and growth rate of atheromas. This paper presents a model for this growth rate, and explores the influence of the bifurcation angle on the blood flow patterns and on the predictions of the model in a simplified carotid artery. The choice of the carotid bifurcation as the subject for this study obeys the fact that atheromas in this artery are often responsible for strokes. Our model predicts a larger initial growth rate in the external walls of the bifurcation and smaller growth area and lower growth rates as the bifurcation angle is increased. The reason for this seems to be the appearance of helical flow patterns as the angle is increased.

  4. Analysis of Partial Volume Effects on Arterial Input Functions Using Gradient Echo: A Simulation Study

    DEFF Research Database (Denmark)

    Kjølby, Birgitte Fuglsang; Mikkelsen, Irene Klærke; Pedersen, Michael

    2009-01-01

    perfusion metrics was investigated for the gradient echo pulse sequence at 1.5 T and 3.0 T. It is shown that the tissue contribution broadens and introduces fluctuations in the AIF. Furthermore, partial volume effects bias perfusion metrics in a nonlinear fashion, compromising quantitative perfusion...

  5. [Arterial CO2- and O2 partial pressure at rest and during exertion in pulmonary emphysema].

    Science.gov (United States)

    Scherrer, M; Zeller, C; Bachofen, H

    1977-07-30

    In 83 patients with severe, largely irreversible bronchial obstruction (FEV1/VC less than 40% and FEV1 after orciprenaline inhalation less than 120% of the control value) and radiologie evidence of AD-emphysema, arterial PCO2 and PO2 were measured at rest in supine position and on the bicycle ergometer during a steady-state exercice of 5 min. Alveolar hypoventilation (PCO2 greater than 45 mm Hg) was most often observed in the cases with FEV1 less than 1.01 (in 22 patients [27%] at rest and in 26 patients [31%] during exercise). However, there was no significant correlation of the PCO2 increase with the degree of bronchial obstruction. In all patients there was a marked inhomogeneity of the alveolar ventilation or the alveolar-capillary O2 transfer in relation to alveolar blood perfusion. Indeed, the alveolar-arterial PO2 difference was increased (40 mm Hg at rest and 45 mm Hg during exercise). The additional increase of this gradient during exercise was due to an unequal distribution of alveolar O2 diffusing capacities in connection with the alveolar blood flow (preceding measurements of the N2 gradient between alveolar air and arterial blood revealed a mean fall from 18 at rest to 8 mm Hg during exercise). The observed deterioration of hypoxemia during exercise (without additional hypercapnia) is to a great extent related to the degree of bronchial obstruction measured by simple spirometry. Thus, measurements of PCO2 and PO2 at rest and during exercise appear to be a helpful adjuvant to routine spirometry in the diagnosis of subclinical emphysema.

  6. Constitutive modelling of an arterial wall supported by microscopic measurements

    Directory of Open Access Journals (Sweden)

    Vychytil J.

    2012-06-01

    Full Text Available An idealized model of an arterial wall is proposed as a two-layer system. Distinct mechanical response of each layer is taken into account considering two types of strain energy functions in the hyperelasticity framework. The outer layer, considered as a fibre-reinforced composite, is modelled using the structural model of Holzapfel. The inner layer, on the other hand, is represented by a two-scale model mimicing smooth muscle tissue. For this model, material parameters such as shape, volume fraction and orientation of smooth muscle cells are determined using the microscopic measurements. The resulting model of an arterial ring is stretched axially and loaded with inner pressure to simulate the mechanical response of a porcine arterial segment during inflation and axial stretching. Good agreement of the model prediction with experimental data is promising for further progress.

  7. PERFORMANCE MODELING AND ANALYSIS OF BLOOD FLOW IN ELASTIC ARTERIES

    Institute of Scientific and Technical Information of China (English)

    Anil Kumar; C.L. Varshney; G.C. Sharma

    2005-01-01

    Two different non-Newtonian models for blood flow are considered, first a simple power law model displaying shear thinning viscosity, and second a generalized Maxwell model displaying both shear thinning viscosity and oscillating flow viscous-elasticity. These models are used along with a Newtonian model to study sinusoidal flow of blood in rigid and elastic straight arteries in the presence of magnetic field. The elasticity of blood does not appear to influence its flow behavior under physiological conditions in the large arteries,purely viscous shear thinning model should be quite realistic for simulating blood flow under these conditions. On using the power law model with high shear rate for sinusoidal flow simulation in elastic arteries, the mean and amplitude of the flow rate were found to be lower for a power law fluid compared to Newtonian fluid for the same pressure gradient. The governing equations have been solved by Crank-Niclson scheme. The results are interpreted in the context of blood in the elastic arteries keeping the magnetic effects in view. For physiological flow simulation in the aorta, an increase in mean wall shear stress, but a reduction in peak wall shear stress were observed for power law model compared to a Newtonian fluid model for matched flow rate wave form. Blood flow in the presence of transverse magnetic field in an elastic artery is investigated and the influence of factors such as morphology and surface irregularity is evaluated.

  8. Superior mesenteric arterial branch occlusion causing partial jejunal ischemia: a case report

    Directory of Open Access Journals (Sweden)

    Van De Winkel Nele

    2012-02-01

    Full Text Available Abstract Introduction Ischemic bowel disease comprises both mesenteric ischemia and colonic ischemia. Mesenteric ischemia can be divided into acute and chronic ischemia. These are two separate entities, each with their specific clinical presentation and diagnostic and therapeutic modalities. However, diagnosis may be difficult due to the vague symptomatology and subtle signs. Case presentation We report the case of a 68-year-old Caucasian woman who presented with abdominal discomfort, anorexia, melena and fever. A physical examination revealed left lower quadrant tenderness and an irregular pulse. Computed tomography of her abdomen as well as computed tomography enterography, enteroscopy, angiography and small bowel enteroclysis demonstrated an ischemic jejunal segment caused by occlusion of a branch of the superior mesenteric artery. The ischemic segment was resected and an end-to-end anastomosis was performed. The diagnosis of segmental small bowel ischemia was confirmed by histopathological study. Conclusion Mesenteric ischemia is a pathology well-known by surgeons, gastroenterologists and radiologists. Acute and chronic mesenteric ischemia are two separate entities with their own specific clinical presentation, radiological signs and therapeutic modalities. We present the case of a patient with symptoms and signs of chronic mesenteric ischemia despite an acute etiology. To the best of our knowledge, this is the first report presenting a case of acute mesenteric ischemia with segmental superior mesenteric artery occlusion.

  9. Partially Compensatory Multidimensional Item Response Theory Models: Two Alternate Model Forms

    Science.gov (United States)

    DeMars, Christine E.

    2016-01-01

    Partially compensatory models may capture the cognitive skills needed to answer test items more realistically than compensatory models, but estimating the model parameters may be a challenge. Data were simulated to follow two different partially compensatory models, a model with an interaction term and a product model. The model parameters were…

  10. Structurally Motivated Models of the Arterial Wall Tissue

    Science.gov (United States)

    Taghizadeh, Hadi; Shadpour, Mohammad Tafazzoli

    2013-05-01

    Mechanical characteristics of soft biological tissues mostly depend on their hierarchy at different scales from nano- to macro-structure. It is shown that arterial wall tissue is highly sensitive to its mechanical environment and any alteration in mechanical factors such as blood pressure, triggers physio- pathological processes within arterial wall. Quantification of these mechanical properties will provide us with deeper insights of ongoing biological events. In this context, mechanical contributions of wall constituents in health and diseases are of growing interest. Hence, this review is concerned with mechanical models of arterial wall tissue with a focus on microstructurally motivated representations.

  11. Propagation of dissection in a residually-stressed artery model.

    Science.gov (United States)

    Wang, Lei; Roper, Steven M; Hill, Nicholas A; Luo, Xiaoyu

    2017-02-01

    This paper studies dissection propagation subject to internal pressure in a residually-stressed two-layer arterial model. The artery is assumed to be infinitely long, and the resultant plane strain problem is solved using the extended finite element method. The arterial layers are modelled using the anisotropic hyperelastic Holzapfel-Gasser-Ogden model, and the tissue damage due to tear propagation is described using a linear cohesive traction-separation law. Residual stress in the arterial wall is determined by an opening angle [Formula: see text] in a stress-free configuration. An initial tear is introduced within the artery which is subject to internal pressure. Quasi-static solutions are computed to determine the critical value of the pressure, at which the dissection starts to propagate. Our model shows that the dissection tends to propagate radially outwards. Interestingly, the critical pressure is higher for both very short and very long tears. The simulations also reveal that the inner wall buckles for longer tears, which is supported by clinical CT scans. In all simulated cases, the critical pressure is found to increase with the opening angle. In other words, residual stress acts to protect the artery against tear propagation. The effect of residual stress is more prominent when a tear is of intermediate length ([Formula: see text]90[Formula: see text] arc length). There is an intricate balance between tear length, wall buckling, fibre orientation, and residual stress that determines the tear propagation.

  12. Giant unruptured middle cerebral artery aneurysm presenting with complex partial seizure: A short review

    OpenAIRE

    Guru Dutta Satyarthee; Manmohan Singh

    2017-01-01

    Intracranial aneurysm is a rare cause of seizure although few cases may develop new onset seizure following rupture of aneurysm. The causes of seizure in ruptured aneurysm may be caused due to presence of subarachnoid hemorrhage, intracerebral hematoma, infarct due to progressive vasospasm, worsening of hydrocephalus, or even after surgical craniotomy for clipping of aneurysm. However, incidental aneurysm solely presenting with complex partial seizure is not reported in literature. To the bes...

  13. Hand-assisted partial nephrectomy with early arterial clamp removal: Impact of the learning curve

    DEFF Research Database (Denmark)

    Azawi, Nessn H; Norus, Thomas P; Wittendorff, Hans-Erik;

    2014-01-01

    OBJECTIVE: The aims of this study were to present the results of hand-assisted laparoscopic partial nephrectomy according to the margin, ischaemia and complications system; to assess the role of the learning curve; and to compare this approach with other approaches. MATERIAL AND METHODS: Data from...... nephrectomy for complex tumours with a relatively high success rate according to the margin, ischaemia and complications system. Warm ischaemia time could be obtained within 5 min after 40 procedures....

  14. Precise Asymptotics of Error Variance Estimator in Partially Linear Models

    Institute of Scientific and Technical Information of China (English)

    Shao-jun Guo; Min Chen; Feng Liu

    2008-01-01

    In this paper, we focus our attention on the precise asymptoties of error variance estimator in partially linear regression models, yi = xTi β + g(ti) +εi, 1 ≤i≤n, {εi,i = 1,... ,n } are i.i.d random errors with mean 0 and positive finite variance q2. Following the ideas of Allan Gut and Aurel Spataru[7,8] and Zhang[21],on precise asymptotics in the Baum-Katz and Davis laws of large numbers and precise rate in laws of the iterated logarithm, respectively, and subject to some regular conditions, we obtain the corresponding results in partially linear regression models.

  15. Global Regularity for Several Incompressible Fluid Models with Partial Dissipation

    Science.gov (United States)

    Wu, Jiahong; Xu, Xiaojing; Ye, Zhuan

    2017-09-01

    This paper examines the global regularity problem on several 2D incompressible fluid models with partial dissipation. They are the surface quasi-geostrophic (SQG) equation, the 2D Euler equation and the 2D Boussinesq equations. These are well-known models in fluid mechanics and geophysics. The fundamental issue of whether or not they are globally well-posed has attracted enormous attention. The corresponding models with partial dissipation may arise in physical circumstances when the dissipation varies in different directions. We show that the SQG equation with either horizontal or vertical dissipation always has global solutions. This is in sharp contrast with the inviscid SQG equation for which the global regularity problem remains outstandingly open. Although the 2D Euler is globally well-posed for sufficiently smooth data, the associated equations with partial dissipation no longer conserve the vorticity and the global regularity is not trivial. We are able to prove the global regularity for two partially dissipated Euler equations. Several global bounds are also obtained for a partially dissipated Boussinesq system.

  16. Global Regularity for Several Incompressible Fluid Models with Partial Dissipation

    Science.gov (United States)

    Wu, Jiahong; Xu, Xiaojing; Ye, Zhuan

    2016-09-01

    This paper examines the global regularity problem on several 2D incompressible fluid models with partial dissipation. They are the surface quasi-geostrophic (SQG) equation, the 2D Euler equation and the 2D Boussinesq equations. These are well-known models in fluid mechanics and geophysics. The fundamental issue of whether or not they are globally well-posed has attracted enormous attention. The corresponding models with partial dissipation may arise in physical circumstances when the dissipation varies in different directions. We show that the SQG equation with either horizontal or vertical dissipation always has global solutions. This is in sharp contrast with the inviscid SQG equation for which the global regularity problem remains outstandingly open. Although the 2D Euler is globally well-posed for sufficiently smooth data, the associated equations with partial dissipation no longer conserve the vorticity and the global regularity is not trivial. We are able to prove the global regularity for two partially dissipated Euler equations. Several global bounds are also obtained for a partially dissipated Boussinesq system.

  17. Global ridge orientation modeling for partial fingerprint identification.

    Science.gov (United States)

    Wang, Yi Alice; Hu, Jiankun

    2011-01-01

    Identifying incomplete or partial fingerprints from a large fingerprint database remains a difficult challenge today. Existing studies on partial fingerprints focus on one-to-one matching using local ridge details. In this paper, we investigate the problem of retrieving candidate lists for matching partial fingerprints by exploiting global topological features. Specifically, we propose an analytical approach for reconstructing the global topology representation from a partial fingerprint. First, we present an inverse orientation model for describing the reconstruction problem. Then, we provide a general expression for all valid solutions to the inverse model. This allows us to preserve data fidelity in the existing segments while exploring missing structures in the unknown parts. We have further developed algorithms for estimating the missing orientation structures based on some a priori knowledge of ridge topology features. Our statistical experiments show that our proposed model-based approach can effectively reduce the number of candidates for pair-wised fingerprint matching, and thus significantly improve the system retrieval performance for partial fingerprint identification.

  18. Time-dependency of improvements in arterial oxygenation during partial liquid ventilation in experimental acute respiratory distress syndrome

    Science.gov (United States)

    Max, Martin; Kuhlen, Ralf; Dembinski, Rolf; Rossaint, Rolf

    2000-01-01

    Background: The mechanisms by which partial liquid ventilation (PLV) can improve gas exchange in acute lung injury are still unclear. Therefore, we examined the time- and dose-dependency of the improvements in arterial oxygen tension (PaO2) due to PLV in eight pigs with experimental lung injury, in order to discriminate increases due to oxygen dissolved in perfluorocarbon before its intrapulmonary instillation from a persistent diffusion of the respiratory gas through the liquid column. Results: Application of four sequential doses of perfluorocarbon resulted in a dose-dependent increase in PaO2. Comparison of measurements 5 and 30 min after instillation of each dose revealed a time-dependent decrease in PaO2 for doses that approximated the functional residual capacity of the animals. Conclusion: Although oxygen dissolved in perfluorocarbon at the onset of PLV can cause a short-term improvement in arterial oxygenation, diffusion of oxygen through the liquid may not be sufficient to maintain the initially observed increase in PaO2. PMID:11056747

  19. The dynamics of pulsatile flow in distensible model arteries.

    Science.gov (United States)

    Liepsch, D W; Zimmer, R

    1995-12-01

    Deposits and blockages are often found in the carotid, coronary, renal and femoral arteries. This paper deals with laser-Doppler velocity measurements in models of bifurcations of the human femoral arteries. Several models were prepared for the studies: a simplified 35 degrees glass model, two elastic-silicone-rubber models with a wall thickness of 1 mm and 2 mm, and true-to-scale rigid and elastic models. These measurements give a clearer picture of how hemodynamics influences the formation of atherosclerotic plaques where there is a hardening of the arterial walls and a loss of elasticity. In addition to the effects of elasticity, the influence of the flow's pulsatility were studied. The measurements were done in steady and pulsatile flow. From the velocity measurements the shear stresses were calculated.

  20. Flow Modelling for partially Cavitating Two-dimensional Hydrofoils

    DEFF Research Database (Denmark)

    Krishnaswamy, Paddy

    2001-01-01

    The present work addresses te computational analysis of partial sheet hydrofoil cavitation in two dimensions. Particular attention is given to the method of simulating the flow at the end of the cavity. A fixed-length partially cavitating panel method is used to predict the height of the re...... of the model and comparing the present calculations with numerical results. The flow around the partially cavitating hydrofoil with a re-entrant jet has also been treated with a viscous/inviscid interactive method. The viscous flow model is based on boundary layer theory applied on the compound foil......, consisting of the union of the cavity and the hydrofoil surface. The change in the flow direction in the cavity closure region is seen to have a slightly adverse effect on the viscous pressure distribution. Otherwise, it is seen that the viscous re-entrant jet solution compares favourably with experimental...

  1. Partial dynamical symmetry in the symplectic shell model

    Energy Technology Data Exchange (ETDEWEB)

    Escher, J. [TRIUMF, Vancouver, British Columbia (Canada); Leviatan, A. [Hebrew Univ., Racah Inst. of Physics, Jerusalem (Israel)

    2000-08-01

    We present an example of a partial dynamical symmetry (PDS) in an interacting fermion system and demonstrate the close relationship of the associated Hamiltonians with a realistic quadrupole-quadrupole interaction, thus shedding light on this important interaction. Specifically, in the framework of the symplectic shell model of nuclei, we prove the existence of a family of fermionic Hamiltonians with partial SU(3) symmetry. We outline the construction process for the PDS eigenstates with good symmetry and give analytic expressions for the energies of these states and E2 transition strengths between them. Characteristics of both pure and mixed-symmetry PDS eigenstates are discussed and the resulting spectra and transition strengths are compared to those of real nuclei. The PDS concept is shown to be relevant to the description of prolate, oblate, as well as triaxially deformed nuclei. Similarities and differences between the fermion case and the previously established partial SU(3) symmetry in the interacting boson model are considered. (author)

  2. Two-Fluid Mathematical Models for Blood Flow in Stenosed Arteries: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Sankar DS

    2009-01-01

    Full Text Available The pulsatile flow of blood through stenosed arteries is analyzed by assuming the blood as a two-fluid model with the suspension of all the erythrocytes in the core region as a non-Newtonian fluid and the plasma in the peripheral layer as a Newtonian fluid. The non-Newtonian fluid in the core region of the artery is assumed as a (i Herschel-Bulkley fluid and (ii Casson fluid. Perturbation method is used to solve the resulting system of non-linear partial differential equations. Expressions for various flow quantities are obtained for the two-fluid Casson model. Expressions of the flow quantities obtained by Sankar and Lee (2006 for the two-fluid Herschel-Bulkley model are used to get the data for comparison. It is found that the plug flow velocity and velocity distribution of the two-fluid Casson model are considerably higher than those of the two-fluid Herschel-Bulkley model. It is also observed that the pressure drop, plug core radius, wall shear stress and the resistance to flow are significantly very low for the two-fluid Casson model than those of the two-fluid Herschel-Bulkley model. Hence, the two-fluid Casson model would be more useful than the two-fluid Herschel-Bulkley model to analyze the blood flow through stenosed arteries.

  3. Mathematical model and simulation of partial penetrated weld pool

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The qualitative analysis on the behavior of partial penetrated weld pool transferring from pulsed peak current to base current in pulsed TIG welding is carried out in this paper. Based on the analysis results, the mathematical models for 3D liquid surface shape of partial penetrated weld pool in pulsed TIG welding are created including surface potential energy model, gravitational energy model and volumetric potential energy. The numerical simulation with these models and the experiments on low carbon steel are carried out using the software Surface Evolver. The simulation results and model are then amended with experimental results. Two important characteristic quantities, the liquid metal coverage ratio and the stripping width of liquid metal, are put forward in this paper, which paves a way for further weld pool full penetration control.

  4. Centrifuge modeling of LNAPL transport in partially saturated sand

    NARCIS (Netherlands)

    Esposito, G.; Allersma, H.G.B.; Selvadurai, A.P.S.

    1999-01-01

    Model tests were performed at the Geotechnical Centrifuge Facility of Delft University of Technology, The Netherlands, to examine the mechanics of light nonaqueous phase liquid (LNAPL) movement in a partially saturated porous granular medium. The experiment simulated a 2D spill of LNAPL in an

  5. Risk and Management Control: A Partial Least Square Modelling Approach

    DEFF Research Database (Denmark)

    Nielsen, Steen; Pontoppidan, Iens Christian

    and interrelations between risk and areas within management accounting. The idea is that management accounting should be able to conduct a valid feed forward but also predictions for decision making including risk. This study reports the test of a theoretical model using partial least squares (PLS) on survey data...

  6. End-tidal arterial CO2 partial pressure gradient in patients with severe hypercapnia undergoing noninvasive ventilation

    Directory of Open Access Journals (Sweden)

    Defilippis V

    2013-06-01

    Full Text Available Vito Defilippis,1 Davide D’Antini,2 Gilda Cinnella,2 Michele Dambrosio,2 Fernando Schiraldi,3 Vito Procacci1 1Emergency Department, Riuniti Hospital, 2Department of Anaesthesiology and Intensive Care, University of Foggia, Foggia, 3Emergency Department, San Paolo Hospital, Naples, Italy Background: Patients with severe hypercapnia represent a particularly serious condition in an emergency department (ED, requiring immediate attention. Noninvasive ventilation (NIV is an integral part of the treatment for acute respiratory failure. The present study aimed to validate the measurement of end-tidal CO2 (EtCO2 as a noninvasive technique to evaluate the effectiveness of NIV in acute hypercapnic respiratory failure. Methods: Twenty consecutive patients admitted to the ED with severe dyspnea were enrolled in the study. NIV by means of bilevel positive airway pressure, was applied to the patients simultaneously with standard medical therapy and continued for 12 hours; the arterial blood gases and side-stream nasal/oral EtCO2 were measured at subsequent times: T0 (admission to the ED, T1h (after 1 hour, T6h (after 6 hours, and T12h (after 12 hours during NIV treatment. Results: The arterial CO2 partial pressure (PaCO2–EtCO2 gradient decreased progressively, reaching at T6h and T12h values lower than baseline (P < 0.001, while arterial pH increased during the observation period (P < 0.001. A positive correlation was found between EtCO2 and PaCO2 values (r = 0.89, P < 0.001 at the end of the observation period. Conclusion: In our hypercapnic patients, the effectiveness of the NIV was evidenced by the progressive reduction of the PaCO2–EtCO2 gradient. The measurement of the CO2 gradient could be a reliable method in monitoring the effectiveness of NIV in acute hypercapnic respiratory failure in the ED. Keywords: arterial end-tidal CO2 gradient, noninvasive ventilation, bilevel positive airway pressure, acute respiratory failure

  7. An Elastoplastic Model for Partially Saturated Collapsible Rocks

    Science.gov (United States)

    Ma, Jianjun

    2016-02-01

    A unified elastoplastic model for describing the stress-strain behavior of partially saturated collapsible rocks is proposed. The elastic-plastic response due to loading and unloading is captured using bounding surface plasticity. The coupling effect of hydraulic and mechanical responses is addressed by applying the effective stress concept. Special attention is paid to the rock-fluid characteristic curve (RFCC), effective stress parameter, and suction hardening. A wide range of saturation degree is considered. The characteristics of mechanical behavior in partially saturated collapsible rocks are captured for all cases considered.

  8. Computational model of collagen turnover in carotid arteries during hypertension.

    Science.gov (United States)

    Sáez, P; Peña, E; Tarbell, J M; Martínez, M A

    2015-02-01

    It is well known that biological tissues adapt their properties because of different mechanical and chemical stimuli. The goal of this work is to study the collagen turnover in the arterial tissue of hypertensive patients through a coupled computational mechano-chemical model. Although it has been widely studied experimentally, computational models dealing with the mechano-chemical approach are not. The present approach can be extended easily to study other aspects of bone remodeling or collagen degradation in heart diseases. The model can be divided into three different stages. First, we study the smooth muscle cell synthesis of different biological substances due to over-stretching during hypertension. Next, we study the mass-transport of these substances along the arterial wall. The last step is to compute the turnover of collagen based on the amount of these substances in the arterial wall which interact with each other to modify the turnover rate of collagen. We simulate this process in a finite element model of a real human carotid artery. The final results show the well-known stiffening of the arterial wall due to the increase in the collagen content.

  9. Partial Dynamical Symmetry in the Symplectic Shell Model

    CERN Document Server

    Escher, J; Escher, Jutta; Leviatan, Amiram

    2002-01-01

    We present an example of a partial dynamical symmetry (PDS) in an interacting fermion system and demonstrate the close relationship of the associated Hamiltonians with a realistic quadrupole-quadrupole interaction, thus shedding new light on this important interaction. Specifically, in the framework of the symplectic shell model of nuclei, we prove the existence of a family of fermionic Hamiltonians with partial SU(3) symmetry. We outline the construction process for the PDS eigenstates with good symmetry and give analytic expressions for the energies of these states and E2 transition strengths between them. Characteristics of both pure and mixed-symmetry PDS eigenstates are discussed and the resulting spectra and transition strengths are compared to those of real nuclei. The PDS concept is shown to be relevant to the description of prolate, oblate, as well as triaxially deformed nuclei. Similarities and differences between the fermion case and the previously established partial SU(3) symmetry in the Interact...

  10. Partial differential equations modeling, analysis and numerical approximation

    CERN Document Server

    Le Dret, Hervé

    2016-01-01

    This book is devoted to the study of partial differential equation problems both from the theoretical and numerical points of view. After presenting modeling aspects, it develops the theoretical analysis of partial differential equation problems for the three main classes of partial differential equations: elliptic, parabolic and hyperbolic. Several numerical approximation methods adapted to each of these examples are analyzed: finite difference, finite element and finite volumes methods, and they are illustrated using numerical simulation results. Although parts of the book are accessible to Bachelor students in mathematics or engineering, it is primarily aimed at Masters students in applied mathematics or computational engineering. The emphasis is on mathematical detail and rigor for the analysis of both continuous and discrete problems. .

  11. A Parallel Lattice Boltzmann Model of a Carotid Artery

    Science.gov (United States)

    Boyd, J.; Ryan, S. J.; Buick, J. M.

    2008-11-01

    A parallel implementation of the lattice Boltzmann model is considered for a three dimensional model of the carotid artery. The computational method and its parallel implementation are described. The performance of the parallel implementation on a Beowulf cluster is presented, as are preliminary hemodynamic results.

  12. Tube-Load Model Parameter Estimation for Monitoring Arterial Hemodynamics

    Directory of Open Access Journals (Sweden)

    Guanqun eZhang

    2011-11-01

    Full Text Available A useful model of the arterial system is the uniform, lossless tube with parametric load. This tube-load model is able to account for wave propagation and reflection (unlike lumped-parameter models such as the Windkessel while being defined by only a few parameters (unlike comprehensive distributed-parameter models. As a result, the parameters may be readily estimated by accurate fitting of the model to available arterial pressure and flow waveforms so as to permit improved monitoring of arterial hemodynamics. In this paper, we review tube-load model parameter estimation techniques that have appeared in the literature for monitoring wave reflection, large artery compliance, pulse transit time, and central aortic pressure. We begin by motivating the use of the tube-load model for parameter estimation. We then describe the tube-load model, its assumptions and validity, and approaches for estimating its parameters. We next summarize the various techniques and their experimental results while highlighting their advantages over conventional techniques. We conclude the review by suggesting future research directions and describing potential applications.

  13. Tube-Load Model Parameter Estimation for Monitoring Arterial Hemodynamics

    Science.gov (United States)

    Zhang, Guanqun; Hahn, Jin-Oh; Mukkamala, Ramakrishna

    2011-01-01

    A useful model of the arterial system is the uniform, lossless tube with parametric load. This tube-load model is able to account for wave propagation and reflection (unlike lumped-parameter models such as the Windkessel) while being defined by only a few parameters (unlike comprehensive distributed-parameter models). As a result, the parameters may be readily estimated by accurate fitting of the model to available arterial pressure and flow waveforms so as to permit improved monitoring of arterial hemodynamics. In this paper, we review tube-load model parameter estimation techniques that have appeared in the literature for monitoring wave reflection, large artery compliance, pulse transit time, and central aortic pressure. We begin by motivating the use of the tube-load model for parameter estimation. We then describe the tube-load model, its assumptions and validity, and approaches for estimating its parameters. We next summarize the various techniques and their experimental results while highlighting their advantages over conventional techniques. We conclude the review by suggesting future research directions and describing potential applications. PMID:22053157

  14. A Partial Unification Model in Non-commutative Geometry

    CERN Document Server

    Hanlon, B E

    1994-01-01

    We consider the construction of $SU(2)_{L}\\otimes SU(2)_{R}\\otimes SU(4)$ partial unification models as an example of phenomenologically acceptable unification models in the absence of supersymmetry in non-commutative geometry. We exploit the Chamseddine, Felder and Fr\\"ohlich generalization of the Connes and Lott model building prescription. By introducing a bi-module structure and appropriate permutation symmetries we construct a model with triplet Higgs fields in the $SU(2)$ sectors and spontaneous breaking of $SU(4)$.

  15. Intuitive model for the scintillations of a partially coherent beam.

    Science.gov (United States)

    Efimov, Anatoly

    2014-12-29

    An intuitive model for the scintillation index of a partially coherent beam is developed in which essentially the only critical parameter is the properly defined Fresnel number equal to the ratio of the "working" aperture area to the area of the Fresnel zone. The model transpired from and is supported by numerical simulations using Rytov method for weak fluctuations regime and Tatarskii turbulence spectrum with inner scale. The ratio of the scintillation index of a partially coherent beam to that of a plane wave displays a characteristic minimum, the magnitude of which and its distance from the transmitter are easily explained using the intuitive model. A theoretical asymptotic is found for the scintillation index of a source with decreasing coherence at this minimum.

  16. Regeneration and Cell Recruitment in an Improved Heterotopic Auxiliary Partial Liver Transplantation Model in the Rat.

    Science.gov (United States)

    Ono, Yoshihiro; Pérez-Gutiérrez, Angelica; Yovchev, Mladen I; Matsubara, Kentaro; Yokota, Shinichiro; Guzman-Lepe, Jorge; Handa, Kan; Collin de l'Hortet, Alexandra; Thomson, Angus W; Geller, David A; Yagi, Hiroshi; Oertel, Michael; Soto-Gutierrez, Alejandro

    2017-01-01

    Auxiliary partial liver transplantation (APLT) in humans is a therapeutic modality used especially to treat liver failure in children or congenital metabolic disease. Animal models of APLT have helped to explore therapeutic options. Though many groups have suggested improvements, standardizing the surgical procedure has been challenging. Additionally, the question of whether graft livers are reconstituted by recipient-derived cells after transplantation has been controversial. The aim of this study was to improve experimental APLT in rats and to assess cell recruitment in the liver grafts. To inhibit recipient liver regeneration and to promote graft regeneration, we treated recipients with retrorsine and added arterial anastomosis. Using green fluorescence protein transgenic rats as recipients, we examined liver resident cell recruitment within graft livers by immunofluorescence costaining. In the improved APLT model, we achieved well-regenerated grafts that could maintain regeneration for at least 4 weeks. Regarding the cell recruitment, there was no evidence of recipient-derived hepatocyte, cholangiocyte, or hepatic stellate cell recruitment into the graft. Macrophages/monocytes, however, were consistently recruited into the graft and increased over time, which might be related to inflammatory responses. Very few endothelial cells showed colocalization of markers. We have successfully established an improved rat APLT model with arterial anastomosis as a standard technique. Using this model, we have characterized cell recruitment into the regenerating grafts.

  17. Estimation in partial linear EV models with replicated observations

    Institute of Scientific and Technical Information of China (English)

    CUI; Hengjian

    2004-01-01

    The aim of this work is to construct the parameter estimators in the partial linear errors-in-variables (EV) models and explore their asymptotic properties. Unlike other related References, the assumption of known error covariance matrix is removed when the sample can be repeatedly drawn at each designed point from the model. The estimators of interested regression parameters, and the model error variance, as well as the nonparametric function, are constructed. Under some regular conditions, all of the estimators prove strongly consistent. Meanwhile, the asymptotic normality for the estimator of regression parameter is also presented. A simulation study is reported to illustrate our asymptotic results.

  18. [General systems theory, analog models and essential arterial hypertension].

    Science.gov (United States)

    Indovina, I; Bonelli, M

    1991-02-15

    The application of the General System Theory to the fields of biology and particularly of medicine is fraught with many difficulties deriving from the mathematical complexities of application. The authors suggest that these difficulties can be overcome by applying analogical models, thus opening new prospects for the resolution of the manifold problems involved in connection with the study of arterial hypertension.

  19. Artery Soft-Tissue Modelling for Stent Implant Training System

    Directory of Open Access Journals (Sweden)

    Giovanni Aloisio

    2004-08-01

    Full Text Available Virtual reality technology can be utilised to provide new systematic training methods for surgical procedures. Our aim is to build a simulator that allows medical students to practice the coronary stent implant procedure and avoids exposing patients to risks. The designed simulation system consists of a virtual environment and a haptic interface, in order to provide both the visualization of the coronary arteries and the tactile and force feedback generated during the interactions of the surgical instruments in the virtual environment. Since the arteries are soft tissues, their shape may change during an operation; for this reason physical modelling of the organs is necessary to render their behaviour under the influence of surgeon's instruments. The idea is to define a model that computes the displacement of the tissue versus time; from the displacement it is possible to calculate the response of the tissue to the surgical tool external stimuli. Information about tools displacements and tissue responses are also used to graphically model the artery wall and virtual surgical instrument deformations generated as a consequence of their coming into contact. In order to obtain a realistic simulation, the Finite Element Method has been used to model the soft tissues of the artery, using linear elasticity to reduce computational time and speed up interaction rates.

  20. Tissue Characterization on Common Carotid Artery using AR Model

    Science.gov (United States)

    Koya, Yoshiharu; Mizoshiri, Isao

    This study uses one image with a echocardiography and detects arteriosclerosis on the common carotid artery by tissue characterization. The conventional methods are measurement of thickness on the vessel wall or stiffness on the common carotid artery. However, they need frames of several beats and great calculation times. But, we detect the arteriosclerosis with only one image. Our method estimate the grade of arteriosclerosis by AR model parameters fitted to the texture on the lumen-intima wall. Experimental results show the validity of the proposed method.

  1. Partial Least Squares Structural Equation Modeling with R

    Directory of Open Access Journals (Sweden)

    Hamdollah Ravand

    2016-09-01

    Full Text Available Structural equation modeling (SEM has become widespread in educational and psychological research. Its flexibility in addressing complex theoretical models and the proper treatment of measurement error has made it the model of choice for many researchers in the social sciences. Nevertheless, the model imposes some daunting assumptions and restrictions (e.g. normality and relatively large sample sizes that could discourage practitioners from applying the model. Partial least squares SEM (PLS-SEM is a nonparametric technique which makes no distributional assumptions and can be estimated with small sample sizes. In this paper a general introduction to PLS-SEM is given and is compared with conventional SEM. Next, step by step procedures, along with R functions, are presented to estimate the model. A data set is analyzed and the outputs are interpreted

  2. semPLS: Structural Equation Modeling Using Partial Least Squares

    Directory of Open Access Journals (Sweden)

    Armin Monecke

    2012-05-01

    Full Text Available Structural equation models (SEM are very popular in many disciplines. The partial least squares (PLS approach to SEM offers an alternative to covariance-based SEM, which is especially suited for situations when data is not normally distributed. PLS path modelling is referred to as soft-modeling-technique with minimum demands regarding mea- surement scales, sample sizes and residual distributions. The semPLS package provides the capability to estimate PLS path models within the R programming environment. Different setups for the estimation of factor scores can be used. Furthermore it contains modular methods for computation of bootstrap confidence intervals, model parameters and several quality indices. Various plot functions help to evaluate the model. The well known mobile phone dataset from marketing research is used to demonstrate the features of the package.

  3. A linearized and incompressible constitutive model for arteries.

    Science.gov (United States)

    Liu, Y; Zhang, W; Wang, C; Kassab, G S

    2011-10-07

    In many biomechanical studies, blood vessels can be modeled as pseudoelastic orthotropic materials that are incompressible (volume-preserving) under physiological loading. To use a minimum number of elastic constants to describe the constitutive behavior of arteries, we adopt a generalized Hooke's law for the co-rotational Cauchy stress and a recently proposed logarithmic-exponential strain. This strain tensor absorbs the material nonlinearity and its trace is zero for volume-preserving deformations. Thus, the relationships between model parameters due to the incompressibility constraint are easy to analyze and interpret. In particular, the number of independent elastic constants reduces from ten to seven in the orthotropic model. As an illustratory study, we fit this model to measured data of porcine coronary arteries in inflation-stretch tests. Four parameters, n (material nonlinearity), Young's moduli E₁ (circumferential), E₂ (axial), and E₃ (radial) are necessary to fit the data. The advantages and limitations of this model are discussed.

  4. Modelling of partially-resolved oceanic symmetric instability

    Science.gov (United States)

    Bachman, S. D.; Taylor, J. R.

    2014-10-01

    A series of idealized numerical models have been developed to investigate the effects of partially resolved symmetric instability (SI) in oceanic general circulation models. An analysis of the energetics of symmetric instability is used to argue that the mixed layer can be at least partially restratified even when some SI modes are absent due to either large horizontal viscosity or coarse model resolution. Linear stability analysis reveals that in the idealized models the amount of restratification can be predicted as a function of the grid spacing and viscosity. The models themselves are used to demonstrate these predictions and reveal three possible outcomes in steady-state: (1) incomplete restratification due to viscosity, (2) incomplete restratification due to resolution, and (3) excessive restratification due to anisotropy of the viscosity. The third outcome occurs even on a high-resolution isotropic grid and in two separate numerical models, and thus appears to be a sort of robust numerical feature. The three outcomes are used to recommend criteria that a successful SI parameterization should satisfy.

  5. AN APPROACH IN MODELING TWO-DIMENSIONAL PARTIALLY CAVITATING FLOW

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    An approach of modeling viscosity, unsteady partially cavitating flows around lifting bodies is presented. By employing an one-fluid Navier-Stokers solver, the algorithm is proved to be able to handle two-dimensional laminar cavitating flows at moderate Reynolds number. Based on the state equation of water-vapor mixture, the constructive relations of densities and pressures are established. To numerically simulate the cavity wall, different pseudo transition of density models are presumed. The finite-volume method is adopted and the algorithm can be extended to three-dimensional cavitating flows.

  6. Safety modeling of urban arterials in Shanghai, China.

    Science.gov (United States)

    Wang, Xuesong; Fan, Tianxiang; Chen, Ming; Deng, Bing; Wu, Bing; Tremont, Paul

    2015-10-01

    Traffic safety on urban arterials is influenced by several key variables including geometric design features, land use, traffic volume, and travel speeds. This paper is an exploratory study of the relationship of these variables to safety. It uses a comparatively new method of measuring speeds by extracting GPS data from taxis operating on Shanghai's urban network. This GPS derived speed data, hereafter called Floating Car Data (FCD) was used to calculate average speeds during peak and off-peak hours, and was acquired from samples of 15,000+ taxis traveling on 176 segments over 18 major arterials in central Shanghai. Geometric design features of these arterials and surrounding land use characteristics were obtained by field investigation, and crash data was obtained from police reports. Bayesian inference using four different models, Poisson-lognormal (PLN), PLN with Maximum Likelihood priors (PLN-ML), hierarchical PLN (HPLN), and HPLN with Maximum Likelihood priors (HPLN-ML), was used to estimate crash frequencies. Results showed the HPLN-ML models had the best goodness-of-fit and efficiency, and models with ML priors yielded estimates with the lowest standard errors. Crash frequencies increased with increases in traffic volume. Higher average speeds were associated with higher crash frequencies during peak periods, but not during off-peak periods. Several geometric design features including average segment length of arterial, number of lanes, presence of non-motorized lanes, number of access points, and commercial land use, were positively related to crash frequencies.

  7. A minimal model of self-consistent partial synchrony

    Science.gov (United States)

    Clusella, Pau; Politi, Antonio; Rosenblum, Michael

    2016-09-01

    We show that self-consistent partial synchrony in globally coupled oscillatory ensembles is a general phenomenon. We analyze in detail appearance and stability properties of this state in possibly the simplest setup of a biharmonic Kuramoto-Daido phase model as well as demonstrate the effect in limit-cycle relaxational Rayleigh oscillators. Such a regime extends the notion of splay state from a uniform distribution of phases to an oscillating one. Suitable collective observables such as the Kuramoto order parameter allow detecting the presence of an inhomogeneous distribution. The characteristic and most peculiar property of self-consistent partial synchrony is the difference between the frequency of single units and that of the macroscopic field.

  8. Matching models of left ventricle and systemic artery

    Institute of Scientific and Technical Information of China (English)

    柳兆荣; 吴驰

    1997-01-01

    To reveal how the matching models of the left ventricle and its afterload affect the pressure and flow in the aortic root, the differences between the measured pressure and flow waveforms and those determined by three kinds of matching model were compared. The results showed that, compared with the results by both matching models 1 and 2, the pressure and flow waveforms determined by matching model 3 established in this work were in the closest agreement with the corresponding experimental waveforms, therefore indicating that matching model 3 was a matching model that closely and rationally characterized the match between the left ventricle and the systemic artery.

  9. Influence Diagnostics in Partially Varying-Coefficient Models

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    When a real-world data set is fitted to a specific type of models, it is often encountered that one or a set of observations have undue influence on the model fitting, which may lead to misleading conclusions. Therefore, it is necessary for data analysts to identify these influential observations and assess their impact on various aspects of model fitting. In this paper, one type of modified Cook's distances is defined to gauge the influence of one or a set observations on the estimate of the constant coefficient part in partially varying-coefficient models, and the Cook's distances are expressed as functions of the corresponding residuals and leverages. Meanwhile, a bootstrap procedure is suggested to derive the reference values for the proposed Cook's distances. Some simulations are conducted, and a real-world data set is further analyzed to examine the performance of the proposed method. The experimental results are satisfactory.

  10. Modeling Partial Attacks with Alloy (Transcript of Discussion)

    Science.gov (United States)

    Lin, Amerson

    The reason we went into this research, was that we found that partial attacks were extremely hard to model in terms of a language that could be used by an automated tool. Now there are three reasons why this is so. The first is that it is hard to identify these attacks even by hand, because you have to be really creative in thinking, what constitutes a reduction in entropy of the secret, that is significant, because a partial attack is really anything that reduces entropy, it's just that it does not reduce the entropy to zero, which would be a case of a complete attack. Next, it's hard to describe that in a formal language, part of that problem comes from the definition, you have to define what you want to be the goal, if the secret is the entire password, then getting one letter is pretty much a partial attack, but if the secret is that one letter, then getting that one letter is a complete attack. And lastly, applying that logic, how do you measure entropy, how do you measure information leakage, that's also very difficult.

  11. Establishment of a new pig model for auxiliary partial orthotopic liver transplantation

    Institute of Scientific and Technical Information of China (English)

    Cheng-Hong Peng; Liu-Bin Shi; Hong-Wei Zhang; Shu-You Peng; Guang-Wen Zhou; Hong-Wei Li

    2005-01-01

    AIM: To establish a new pig model for auxiliary partial orthotopic liver transplantation (APOLT).METHODS: The liver of the donor was removed from its body. The left lobe of the liver was resected in vivo and the right lobe was used as a graft. After the left lateral lobe of the recipient was resected, end-to-side anastomoses of suprahepatic inferior vena cava and portal vein were performed between the donor and recipient livers,respectively. End-to-end anastomoses were made between hepatic artery of graft and splenic artery of the host.Outside drainage was placed in donor common bile duct.RESULTS: Models of APOLT were established in 5 pigs with a success rate of 80%. Color ultrasound examination showed an increase of blood flow of graft on 5th d compared to the first day after operation. When animals were killed on the 5th d after operation, thrombosis of hepatic vein (HV) and portal vein (PV) were not found. Histopathological examination of liver samples revealed evidence of damage with mild steatosis and sporadic necrotic hepatocytes and focal hepatic lobules structure disorganized in graft. Infiltration of inflammatory cells was mild in portal or central vein area. Hematologic laboratory values and blood chemical findings revealed that compared with group A (before transplantation), mean arterial pressure (MAP), central venous pressure (CVP), buffer base (BB), standard bicarbonate (SB) and K+ in group B (after portal vein was clamped) decreased (P<0.01). After reperfusion of the graft, MAP, CVP and K+ restored gradually.CONCLUSION: Significant decrease of congestion in portal vein and shortened blocking time were obtained because of the application of in vitro veno-venous bypass during complete vascular clamping. This new procedure,with such advantages as simple vessel processing, quality anastomosis, less postoperative hemorrhage and higher success rate, effectively prevents ischemia reperfusion injury of the host liver and deserves to be spread.

  12. Partial differential equation models in the socio-economic sciences

    KAUST Repository

    Burger, Martin

    2014-10-06

    Mathematical models based on partial differential equations (PDEs) have become an integral part of quantitative analysis in most branches of science and engineering, recently expanding also towards biomedicine and socio-economic sciences. The application of PDEs in the latter is a promising field, but widely quite open and leading to a variety of novel mathematical challenges. In this introductory article of the Theme Issue, we will provide an overview of the field and its recent boosting topics. Moreover, we will put the contributions to the Theme Issue in an appropriate perspective.

  13. Estimation and variable selection for generalized additive partial linear models

    KAUST Repository

    Wang, Li

    2011-08-01

    We study generalized additive partial linear models, proposing the use of polynomial spline smoothing for estimation of nonparametric functions, and deriving quasi-likelihood based estimators for the linear parameters. We establish asymptotic normality for the estimators of the parametric components. The procedure avoids solving large systems of equations as in kernel-based procedures and thus results in gains in computational simplicity. We further develop a class of variable selection procedures for the linear parameters by employing a nonconcave penalized quasi-likelihood, which is shown to have an asymptotic oracle property. Monte Carlo simulations and an empirical example are presented for illustration. © Institute of Mathematical Statistics, 2011.

  14. Reconstructing parameters of spreading models from partial observations

    CERN Document Server

    Lokhov, Andrey Y

    2016-01-01

    Spreading processes are often modelled as a stochastic dynamics occurring on top of a given network with edge weights corresponding to the transmission probabilities. Knowledge of veracious transmission probabilities is essential for prediction, optimization, and control of diffusion dynamics. Unfortunately, in most cases the transmission rates are unknown and need to be reconstructed from the spreading data. Moreover, in realistic settings it is impossible to monitor the state of each node at every time, and thus the data is highly incomplete. We introduce an efficient dynamic message-passing algorithm, which is able to reconstruct parameters of the spreading model given only partial information on the activation times of nodes in the network. The method is generalizable to a large class of dynamic models, as well to the case of temporal graphs.

  15. Quantifying [{sup 18}F]fluorodeoxyglucose uptake in the arterial wall: the effects of dual time-point imaging and partial volume effect correction

    Energy Technology Data Exchange (ETDEWEB)

    Blomberg, Bjoern A. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Odense University Hospital, Department of Nuclear Medicine, Odense (Denmark); Bashyam, Arjun; Ramachandran, Abhinay; Gholami, Saeid; Houshmand, Sina; Salavati, Ali; Werner, Tom; Alavi, Abass [Hospital of the University of Pennsylvania, Department of Radiology, Philadelphia, PA (United States); Zaidi, Habib [Geneva University Hospital, Division of Nuclear Medicine and Molecular Imaging, Geneva (Switzerland); University of Groningen, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen (Netherlands)

    2015-08-15

    The human arterial wall is smaller than the spatial resolution of current positron emission tomographs. Therefore, partial volume effects should be considered when quantifying arterial wall {sup 18}F-FDG uptake. We evaluated the impact of a novel method for partial volume effect (PVE) correction with contrast-enhanced CT (CECT) assistance on quantification of arterial wall {sup 18}F-FDG uptake at different imaging time-points. Ten subjects were assessed by CECT imaging and dual time-point PET/CT imaging at approximately 60 and 180 min after {sup 18}F-FDG administration. For both time-points, uptake of {sup 18}F-FDG was determined in the aortic wall by calculating the blood pool-corrected maximum standardized uptake value (cSUV{sub MAX}) and cSUV{sub MEAN}. The PVE-corrected SUV{sub MEAN} (pvcSUV{sub MEAN}) was also calculated using {sup 18}F-FDG PET/CT and CECT images. Finally, corresponding target-to-background ratios (TBR) were calculated. At 60 min, pvcSUV{sub MEAN} was on average 3.1 times greater than cSUV{sub MAX} (P <.0001) and 8.5 times greater than cSUV{sub MEAN} (P <.0001). At 180 min, pvcSUV{sub MEAN} was on average 2.6 times greater than cSUV{sub MAX} (P <.0001) and 6.6 times greater than cSUV{sub MEAN} (P <.0001). This study demonstrated that CECT-assisted PVE correction significantly influences quantification of arterial wall {sup 18}F-FDG uptake. Therefore, partial volume effects should be considered when quantifying arterial wall {sup 18}F-FDG uptake with PET. (orig.)

  16. Abnormal arterial flows by a distributed model of the fetal circulation.

    Science.gov (United States)

    van den Wijngaard, Jeroen P H M; Westerhof, Berend E; Faber, Dirk J; Ramsay, Margaret M; Westerhof, Nico; van Gemert, Martin J C

    2006-11-01

    Modeling the propagation of blood pressure and flow along the fetoplacental arterial tree may improve interpretation of abnormal flow velocity waveforms in fetuses. The current models, however, either do not include a wide range of gestational ages or do not account for variation in anatomical, vascular, or rheological parameters. We developed a mathematical model of the pulsating fetoumbilical arterial circulation using Womersley's oscillatory flow theory and viscoelastic arterial wall properties. Arterial flow waves are calculated at different arterial locations from which the pulsatility index (PI) can be determined. We varied blood viscosity, placental and brain resistances, placental compliance, heart rate, stiffness of the arterial wall, and length of the umbilical arteries. The PI increases in the umbilical artery and decreases in the cerebral arteries, as a result of increasing placental resistance or decreasing brain resistance. Both changes in resistance decrease the flow through the placenta. An increased arterial stiffness increases the PIs in the entire fetoplacental circulation. Blood viscosity and peripheral bed compliance have limited influence on the flow profiles. Bradycardia and tachycardia increase and decrease the PI in all arteries, respectively. Umbilical arterial length has limited influence on the PI but affects the mean arterial pressure at the placental cord insertion. The model may improve the interpretation of arterial flow pulsations and thus may advance both the understanding of pathophysiological processes and clinical management.

  17. The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models.

    Science.gov (United States)

    Brito, Marlon V; de Oliveira, Cleide; Salu, Bruno R; Andrade, Sonia A; Malloy, Paula M D; Sato, Ana C; Vicente, Cristina P; Sampaio, Misako U; Maffei, Francisco H A; Oliva, Maria Luiza V

    2014-05-01

    The Bauhinia bauhinioides Kallikrein Inhibitor (BbKI) is a Kunitz-type serine peptidase inhibitor of plant origin that has been shown to impair the viability of some tumor cells and to feature a potent inhibitory activity against human and rat plasma kallikrein (Kiapp 2.4 nmol/L and 5.2 nmol/L, respectively). This inhibitory activity is possibly responsible for an effect on hemostasis by prolonging activated partial thromboplastin time (aPTT). Because the association between cancer and thrombosis is well established, we evaluated the possible antithrombotic activity of this protein in venous and arterial thrombosis models. Vein thrombosis was studied in the vena cava ligature model in Wistar rats, and arterial thrombosis in the photochemical induced endothelium lesion model in the carotid artery of C57 black 6 mice. BbKI at a concentration of 2.0 mg/kg reduced the venous thrombus weight by 65% in treated rats in comparison to rats in the control group. The inhibitor prolonged the time for total artery occlusion in the carotid artery model mice indicating that this potent plasma kallikrein inhibitor prevented thrombosis.

  18. Linear and nonlinear viscoelastic arterial wall models: application on animals

    CERN Document Server

    Ghigo, Arthur; Armentano, Ricardo; Lagrée, Pierre-Yves; Fullana, Jose-Maria

    2016-01-01

    This work deals with the viscoelasticity of the arterial wall and its influence on the pulse waves. We describe the viscoelasticity by a non-linear Kelvin-Voigt model in which the coefficients are fitted using experimental time series of pressure and radius measured on a sheep's arterial network. We obtained a good agreement between the results of the nonlinear Kelvin-Voigt model and the experimental measurements. We found that the viscoelastic relaxation time-defined by the ratio between the viscoelastic coefficient and the Young's modulus-is nearly constant throughout the network. Therefore, as it is well known that smaller arteries are stiffer, the viscoelastic coefficient rises when approaching the peripheral sites to compensate the rise of the Young's modulus, resulting in a higher damping effect. We incorporated the fitted viscoelastic coefficients in a nonlinear 1D fluid model to compute the pulse waves in the network. The damping effect of viscoelasticity on the high frequency waves is clear especiall...

  19. An XFEM Model for Hydraulic Fracturing in Partially Saturated Rocks

    Directory of Open Access Journals (Sweden)

    Salimzadeh Saeed

    2016-01-01

    Full Text Available Hydraulic fracturing is a complex multi-physics phenomenon. Numerous analytical and numerical models of hydraulic fracturing processes have been proposed. Analytical solutions commonly are able to model the growth of a single hydraulic fracture into an initially intact, homogeneous rock mass. Numerical models are able to analyse complex problems such as multiple hydraulic fractures and fracturing in heterogeneous media. However, majority of available models are restricted to single-phase flow through fracture and permeable porous rock. This is not compatible with actual field conditions where the injected fluid does not have similar properties as the host fluid. In this study we present a fully coupled hydro-poroelastic model which incorporates two fluids i.e. fracturing fluid and host fluid. Flow through fracture is defined based on lubrication assumption, while flow through matrix is defined as Darcy flow. The fracture discontinuity in the mechanical model is captured using eXtended Finite Element Method (XFEM while the fracture propagation criterion is defined through cohesive fracture model. The discontinuous matrix fluid velocity across fracture is modelled using leak-off loading which couples fracture flow and matrix flow. The proposed model has been discretised using standard Galerkin method, implemented in Matlab and verified against several published solutions. Multiple hydraulic fracturing simulations are performed to show the model robustness and to illustrate how problem parameters such as injection rate and rock permeability affect the hydraulic fracturing variables i.e. injection pressure, fracture aperture and fracture length. The results show the impact of partial saturation on leak-off and the fact that single-phase models may underestimate the leak-off.

  20. A partial differential equation model of metastasized prostatic cancer.

    Science.gov (United States)

    Friedman, Avner; Jain, Harsh Vardhan

    2013-06-01

    Biochemically failing metastatic prostate cancer is typically treated with androgen ablation. However, due to the emergence of castration-resistant cells that can survive in low androgen concentrations, such therapy eventually fails. Here, we develop a partial differential equation model of the growth and response to treatment of prostate cancer that has metastasized to the bone. Existence and uniqueness results are derived for the resulting free boundary problem. In particular, existence and uniqueness of solutions for all time are proven for the radially symmetric case. Finally, numerical simulations of a tumor growing in 2-dimensions with radial symmetry are carried in order to evaluate the therapeutic potential of different treatment strategies. These simulations are able to reproduce a variety of clinically observed responses to treatment, and suggest treatment strategies that may result in tumor remission, underscoring our model's potential to make a significant contribution in the field of prostate cancer therapeutics.

  1. Modeling tree crown dynamics with 3D partial differential equations.

    Science.gov (United States)

    Beyer, Robert; Letort, Véronique; Cournède, Paul-Henry

    2014-01-01

    We characterize a tree's spatial foliage distribution by the local leaf area density. Considering this spatially continuous variable allows to describe the spatiotemporal evolution of the tree crown by means of 3D partial differential equations. These offer a framework to rigorously take locally and adaptively acting effects into account, notably the growth toward light. Biomass production through photosynthesis and the allocation to foliage and wood are readily included in this model framework. The system of equations stands out due to its inherent dynamic property of self-organization and spontaneous adaptation, generating complex behavior from even only a few parameters. The density-based approach yields spatially structured tree crowns without relying on detailed geometry. We present the methodological fundamentals of such a modeling approach and discuss further prospects and applications.

  2. Modeling Tree Crown Dynamics with 3D Partial Differential Equations

    Directory of Open Access Journals (Sweden)

    Robert eBeyer

    2014-07-01

    Full Text Available We characterize a tree's spatial foliage distribution by the local leaf area density. Considering this spatially continuous variable allows to describe the spatiotemporal evolution of the tree crown by means of 3D partial differential equations. These offer a framework to rigorously take locally and adaptively acting effects into account, notably the growth towards light. Biomass production through photosynthesis and the allocation to foliage and wood are readily included in this model framework. The system of equations stands out due to its inherent dynamic property of self-organization and spontaneous adaptation, generating complex behavior from even only a few parameters. The density-based approach yields spatially structured tree crowns without relying on detailed geometry. We present the methodological fundamentals of such a modeling approach and discuss further prospects and applications.

  3. Partial equilibrium model – Case study of the poultry market

    Directory of Open Access Journals (Sweden)

    Lenka Šobrová

    2011-01-01

    Full Text Available This paper deals with identifying the main determinants in the poultry agri-food chain in the Czech Republic and examines their relationships. The partial equilibrium model, defined as a seven-equation model in power form, is employed for this purpose. The analysis is based on both time-series and panel data of the main factors in the poultry market. The time-series as well as panel data contain annual data of selected variables for the period from 1995 to 2009. The analysis is focused on supply and demand of poultry meat, specifically on production, consumption and foreign trade in poultry meat in the Czech Republic. Firstly, the main factors influencing the poultry market are determined, then, an appropriate model is employed. The parameters of the model are estimated using the ordinary least squares method in statistical and econometric software. Estimated parameters confirm assumed relationships among the selected variables. Moreover, the long-term tendencies of the selected indicators are proven. Among other, the analysis proves an inertial consumption, the price level as the main factor influencing the consumption and one-way or mutual relationship among the selected variables. The statistical features of the model are satisfied as well – the estimated parameters are statistically significant, the model does not contain, neither the problem of autocorrelation of residuals nor the problem of heteroskedasticity.

  4. Safety modeling of suburban arterials in Shanghai, China.

    Science.gov (United States)

    Wang, Xuesong; Song, Yang; Yu, Rongjie; Schultz, Grant G

    2014-09-01

    As urbanization accelerates in Shanghai, land continues to develop along suburban arterials which results in more access points along the roadways and more congested suburban arterials; all these changes have led to deterioration in traffic safety. In-depth safety analysis is needed to understand the relationship between roadway geometric design, access features, traffic characteristics, and safety. This study examined 161 road segments (each between two adjacent signalized intersections) of eight suburban arterials in Shanghai. Information on signal spacing, geometric design, access features, traffic characteristics, and surrounding area types were collected. The effect of these factors on total crash occurrence was investigated. To account for the hierarchical data structure, hierarchical Bayesian models were developed for total crashes. To identify diverse effects on different crash injury severity, the total crashes were separated into minor injury and severe injury crashes. Bivariate hierarchical Bayesian models were developed for minor injury and severe injury to account for the correlation among different severity levels. The modeling results show that the density of signal spacing along arterials has a significant influence on minor injury, severe injury, and total crash frequencies. The non-uniform signal spacing has a significant impact on the occurrence of minor injury crashes. At the segment-level, higher frequencies of minor injury, severe injury, and total crashes tend to occur for the segments with curves, those with a higher density of access points, those with a higher percentage of heavy vehicles, and those in inner suburban areas. This study is useful for applications such as related engineering safety improvements and making access management policy.

  5. MODELLING AND CONTROL OF PARTIALLY SHADED PHOTOVOLTAIC ARRAYS

    Directory of Open Access Journals (Sweden)

    Chia Seet Chin

    2013-01-01

    Full Text Available The photovoltaic (PV array controlled by Maximum Power Point Tracking (MPPT method for optimum PV power generation, particularly when the PV array is under partially shaded condition is presented in this paper. The system modelling is carried out in MATLAB-SIMULINK where the PV array is formed by five series connected identical PV modules. Under uniform solar irradiance conditions, the PV module and the PV array present nonlinear P-V characteristic but the maximum power point (MPP can be easily identified. However, when the PV array is under shaded conditions, the P-V characteristic becomes more complex with the present of multiple MPP. While the PV array operated at local MPP, the generated power is limited. Thus, the investigation on MPPT approach is carried out to maximize the PV generated power even when the PV array is under partially shaded conditions (PSC. Fuzzy logic is adopted into the conventional MPPT to form fuzzy logic based MPPT (FMPPT for better performance. The developed MPPT and FMPPT are compared, particularly the performances on the transient response and the steady state response when the array is under various shaded conditions. FMPPT shows better performance where the simulation results demonstrate FMPPT is able to facilitate the PV array to reach the MPP faster while it helps the PV array to produce a more stable output power.

  6. Modeling of formation of intraplate partial melting zones

    Science.gov (United States)

    Perepechko, Y. V.; Sorokin, K. E.

    2010-12-01

    This study suggests the mathematical model of dynamics of partial melting in lithosphere causing formation of magmatic systems. The intraplate magmatic systems can be formed at achievement of required thermodynamic conditions, which can be developed due to the following mechanisms: contact heating; decompression melting at mantle matter penetration into lithosphere; and heating by filtering mantle melts and fluids in the weakened lithosphere zones above the asthenospheric structure related to a hotspot. The most efficient mechanism from the point of time and heating degree is the latter one. It is heating of lithosphere matter by mantle melts and fluids, which is especially important for development of melting sites in these systems. At formation of intraplate magmatic systems the fluid is filtered in a porous medium, porous matrix melts partially, and finally a granulated medium is formed there. To decrease the processes of heat and mass transfer in this system, the equations of dynamics of multiphase multivelocity media are derived in this study. In contrast to the Darcy-type models used in previous studies, the suggested two-velocity hydrodynamics theory describing fluid motions in a porous medium with complex reology is the thermodynamically consistent one and allows the description of nonstationary nonlinear processes. The governing equations of the model describe both the process of filtration through the deformed porous matrix and hydrodynamics of heterophase granulated medium without pressure equilibrium in phases. The work was supported by the grants 08-05-00467, 09-05-00602, 09-05-01084 from the Russian Foundation for Basic Research.

  7. Statistical Inference for Partially Linear Regression Models with Measurement Errors

    Institute of Scientific and Technical Information of China (English)

    Jinhong YOU; Qinfeng XU; Bin ZHOU

    2008-01-01

    In this paper, the authors investigate three aspects of statistical inference for the partially linear regression models where some covariates are measured with errors. Firstly,a bandwidth selection procedure is proposed, which is a combination of the difference-based technique and GCV method. Secondly, a goodness-of-fit test procedure is proposed,which is an extension of the generalized likelihood technique. Thirdly, a variable selection procedure for the parametric part is provided based on the nonconcave penalization and corrected profile least squares. Same as "Variable selection via nonconcave penalized like-lihood and its oracle properties" (J. Amer. Statist. Assoc., 96, 2001, 1348-1360), it is shown that the resulting estimator has an oracle property with a proper choice of regu-larization parameters and penalty function. Simulation studies are conducted to illustrate the finite sample performances of the proposed procedures.

  8. Partial differential equations in action from modelling to theory

    CERN Document Server

    Salsa, Sandro

    2016-01-01

    The book is intended as an advanced undergraduate or first-year graduate course for students from various disciplines, including applied mathematics, physics and engineering. It has evolved from courses offered on partial differential equations (PDEs) over the last several years at the Politecnico di Milano. These courses had a twofold purpose: on the one hand, to teach students to appreciate the interplay between theory and modeling in problems arising in the applied sciences, and on the other to provide them with a solid theoretical background in numerical methods, such as finite elements. Accordingly, this textbook is divided into two parts. The first part, chapters 2 to 5, is more elementary in nature and focuses on developing and studying basic problems from the macro-areas of diffusion, propagation and transport, waves and vibrations. In turn the second part, chapters 6 to 11, concentrates on the development of Hilbert spaces methods for the variational formulation and the analysis of (mainly) linear bo...

  9. Partial differential equations in action from modelling to theory

    CERN Document Server

    Salsa, Sandro

    2015-01-01

    The book is intended as an advanced undergraduate or first-year graduate course for students from various disciplines, including applied mathematics, physics and engineering. It has evolved from courses offered on partial differential equations (PDEs) over the last several years at the Politecnico di Milano. These courses had a twofold purpose: on the one hand, to teach students to appreciate the interplay between theory and modeling in problems arising in the applied sciences, and on the other to provide them with a solid theoretical background in numerical methods, such as finite elements. Accordingly, this textbook is divided into two parts. The first part, chapters 2 to 5, is more elementary in nature and focuses on developing and studying basic problems from the macro-areas of diffusion, propagation and transport, waves and vibrations. In turn the second part, chapters 6 to 11, concentrates on the development of Hilbert spaces methods for the variational formulation and the analysis of (mainly) linear bo...

  10. Risk and Management Control: A Partial Least Square Modelling Approach

    DEFF Research Database (Denmark)

    Nielsen, Steen; Pontoppidan, Iens Christian

    and interrelations between risk and areas within management accounting. The idea is that management accounting should be able to conduct a valid feed forward but also predictions for decision making including risk. This study reports the test of a theoretical model using partial least squares (PLS) on survey data...... and a external attitude dimension. The results have important implications for both management control research and for the management control systems design for the way accountants consider the element of risk in their different tasks, both operational and strategic. Specifically, it seems that different risk......Risk and economic theory goes many year back (e.g. to Keynes & Knight 1921) and risk/uncertainty belong to one of the explanations for the existence of the firm (Coarse, 1937). The present financial crisis going on in the past years have re-accentuated risk and the need of coherence...

  11. Modeling and characterization of partially inserted electrical connector faults

    Science.gov (United States)

    Tokgöz, ćaǧatay; Dardona, Sameh; Soldner, Nicholas C.; Wheeler, Kevin R.

    2016-03-01

    Faults within electrical connectors are prominent in avionics systems due to improper installation, corrosion, aging, and strained harnesses. These faults usually start off as undetectable with existing inspection techniques and increase in magnitude during the component lifetime. Detection and modeling of these faults are significantly more challenging than hard failures such as open and short circuits. Hence, enabling the capability to locate and characterize the precursors of these faults is critical for timely preventive maintenance and mitigation well before hard failures occur. In this paper, an electrical connector model based on a two-level nonlinear least squares approach is proposed. The connector is first characterized as a transmission line, broken into key components such as the pin, socket, and connector halves. Then, the fact that the resonance frequencies of the connector shift as insertion depth changes from a fully inserted to a barely touching contact is exploited. The model precisely captures these shifts by varying only two length parameters. It is demonstrated that the model accurately characterizes a partially inserted connector.

  12. Scaffolding Learning by Modelling: The Effects of Partially Worked-out Models

    Science.gov (United States)

    Mulder, Yvonne G.; Bollen, Lars; de Jong, Ton; Lazonder, Ard W.

    2016-01-01

    Creating executable computer models is a potentially powerful approach to science learning. Learning by modelling is also challenging because students can easily get overwhelmed by the inherent complexities of the task. This study investigated whether offering partially worked-out models can facilitate students' modelling practices and promote…

  13. PERMINTAAN BERAS DI PROVINSI JAMBI (Penerapan Partial Adjustment Model

    Directory of Open Access Journals (Sweden)

    Wasi Riyanto

    2013-07-01

    Full Text Available The purpose of this study is to determine the effect of price of rice, flour prices, population, income of population and demand of rice for a year earlier on rice demand, demand rice elasticity and rice demand prediction in Jambi Province. This study uses secondary data, including time series data for 22 years from 1988 until 2009. The study used some variables, consist of rice demand (Qdt, the price of rice (Hb, the price of wheat flour (Hg, population (Jp, the income of the population (PDRB and demand for rice the previous year (Qdt-1. The make of this study are multiple regression and dynamic analysis a Partial Adjustment Model, where the demand for rice is the dependent variable and the price of rice, flour prices, population, income population and demand of rice last year was the independent variable. Partial Adjustment Model analysis results showed that the effect of changes in prices of rice and flour are not significant to changes in demand for rice. The population and demand of rice the previous year has positive and significant impact on demand for rice, while revenues have negative and significant population of rice demand. Variable price of rice, earning population and the price of flour is inelastic the demand of rice, because rice is not a normal good but as a necessity so that there is no substitution of goods (replacement of rice with other commodities in Jambi Province. Based on the analysis, it is recommended to the government to be able to control the rate of population increase given the variable number of people as one of the factors that affect demand for rice.It is expected that the government also began to socialize in a lifestyle of non-rice food consumption to control the increasing amount of demand for rice. Last suggestion, the government developed a diversification of staple foods other than rice.

  14. One-dimensional Arterial Network Model for Bypass Grafts Assessment

    CERN Document Server

    Ghigo, Arthur; Wang, Xiaofei; Lagrée, Pierre-Yves; Fullana, Jose-Maria

    2016-01-01

    We propose an arterial network model based on 1D blood hemodynamic equations to study the behavior of different vascular surgical bypass grafts in case of an arterial occlusive pathology: an obliteration or stenosis of the iliac artery. We investigate the performances of three different bypass grafts (Aorto-Femoral, Axillo-Femoral and cross-over Femoral) depending on the degree of obliteration of the stenosis. Numerical simulations show that all bypass grafts are efficient since we retrieve in all cases the normal hemodynamics in the stenosed region while ensuring at the same time a global healthy circulation. We analyze in particular the Axillo-Femoral bypass graft by performing hundreds of simulations by varying the values of the Young's modulus [0.1--50 MPa] and the radius [0.01--5 cm] of the bypass graft. We show that the Young's modulus and radius of commercial bypass grafts are optimal in terms of hemodynamic considerations. The numerical findings prove that this approach could be used to optimize or pl...

  15. Computational modeling of fluid structural interaction in arterial stenosis

    Science.gov (United States)

    Bali, Leila; Boukedjane, Mouloud; Bahi, Lakhdar

    2013-12-01

    Atherosclerosis affects the arterial blood vessels causing stenosis because of which the artery hardens resulting in loss of elasticity in the affected region. In this paper, we present: an approach to model the fluid-structure interaction through such an atherosclerosis affected region of the artery, The blood is assumed as an incompressible Newtonian viscous fluid, and the vessel wall was treated as a thick-walled, incompressible and isotropic material with uniform mechanical properties. The numerical simulation has been studied in the context of The Navier-Stokes equations for an interaction with an elastic solid. The study of fluid flow and wall motion was initially carried out separately, Discretized forms of the transformed wall and flow equations, which are coupled through the boundary conditions at their interface, are obtained by control volume method and simultaneously to study the effects of wall deformability, solutions are obtained for both rigid and elastic walls. The results indicate that deformability of the wall causes an increase in the time average of pressure drop, but a decrease in the maximum wall shear stress. Displacement and stress distributions in the wall are presented.

  16. Phase field modeling of partially saturated deformable porous media

    Science.gov (United States)

    Sciarra, Giulio

    2016-09-01

    A poromechanical model of partially saturated deformable porous media is proposed based on a phase field approach at modeling the behavior of the mixture of liquid water and wet air, which saturates the pore space, the phase field being the saturation (ratio). While the standard retention curve is expected still^ to provide the intrinsic retention properties of the porous skeleton, depending on the porous texture, an enhanced description of surface tension between the wetting (liquid water) and the non-wetting (wet air) fluid, occupying the pore space, is stated considering a regularization of the phase field model based on an additional contribution to the overall free energy depending on the saturation gradient. The aim is to provide a more refined description of surface tension interactions. An enhanced constitutive relation for the capillary pressure is established together with a suitable generalization of Darcy's law, in which the gradient of the capillary pressure is replaced by the gradient of the so-called generalized chemical potential, which also accounts for the "force", associated to the local free energy of the phase field model. A micro-scale heuristic interpretation of the novel constitutive law of capillary pressure is proposed, in order to compare the envisaged model with that one endowed with the concept of average interfacial area. The considered poromechanical model is formulated within the framework of strain gradient theory in order to account for possible effects, at laboratory scale, of the micro-scale hydro-mechanical couplings between highly localized flows (fingering) and localized deformations of the skeleton (fracturing).

  17. The Manifest Association Structure of the Single-Factor Model: Insights from Partial Correlations

    Science.gov (United States)

    Salgueiro, Maria de Fatima; Smith, Peter W. F.; McDonald, John W.

    2008-01-01

    The association structure between manifest variables arising from the single-factor model is investigated using partial correlations. The additional insights to the practitioner provided by partial correlations for detecting a single-factor model are discussed. The parameter space for the partial correlations is presented, as are the patterns of…

  18. Turbulence modeling in three-dimensional stenosed arterial bifurcations.

    Science.gov (United States)

    Banks, J; Bressloff, N W

    2007-02-01

    Under normal healthy conditions, blood flow in the carotid artery bifurcation is laminar. However, in the presence of a stenosis, the flow can become turbulent at the higher Reynolds numbers during systole. There is growing consensus that the transitional k-omega model is the best suited Reynolds averaged turbulence model for such flows. Further confirmation of this opinion is presented here by a comparison with the RNG k-epsilon model for the flow through a straight, nonbifurcating tube. Unlike similar validation studies elsewhere, no assumptions are made about the inlet profile since the full length of the experimental tube is simulated. Additionally, variations in the inflow turbulence quantities are shown to have no noticeable affect on downstream turbulence intensity, turbulent viscosity, or velocity in the k-epsilon model, whereas the velocity profiles in the transitional k-omega model show some differences due to large variations in the downstream turbulence quantities. Following this validation study, the transitional k-omega model is applied in a three-dimensional parametrically defined computer model of the carotid artery bifurcation in which the sinus bulb is manipulated to produce mild, moderate, and severe stenosis. The parametric geometry definition facilitates a powerful means for investigating the effect of local shape variation while keeping the global shape fixed. While turbulence levels are generally low in all cases considered, the mild stenosis model produces higher levels of turbulent viscosity and this is linked to relatively high values of turbulent kinetic energy and low values of the specific dissipation rate. The severe stenosis model displays stronger recirculation in the flow field with higher values of vorticity, helicity, and negative wall shear stress. The mild and moderate stenosis configurations produce similar lower levels of vorticity and helicity.

  19. Scaffolding learning by modelling: The effects of partially worked-out models

    NARCIS (Netherlands)

    Mulder, Y.G.; Bollen, Lars; de Jong, Anthonius J.M.; Lazonder, Adrianus W.

    2016-01-01

    Creating executable computer models is a potentially powerful approach to science learning. Learning by modelling is also challenging because students can easily get overwhelmed by the inherent complexities of the task. This study investigated whether offering partially worked-out models can facilit

  20. Groundwater flow modelling of an abandoned partially open repository

    Energy Technology Data Exchange (ETDEWEB)

    Bockgaard, Niclas (Golder Associates AB (Sweden))

    2010-12-15

    As a part of the license application, according to the nuclear activities act, for a final repository for spent nuclear fuel at Forsmark, the Swedish Nuclear Fuel and Waste Management Company (SKB) has undertaken a series of groundwater flow modelling studies. These represent time periods with different hydraulic conditions and the simulations carried out contribute to the overall evaluation of the repository design and long-term radiological safety. The modelling study presented here serves as an input for analyses of so-called future human actions that may affect the repository. The objective of the work was to investigate the hydraulic influence of an abandoned partially open repository. The intention was to illustrate a pessimistic scenario of the effect of open tunnels in comparison to the reference closure of the repository. The effects of open tunnels were studied for two situations with different boundary conditions: A 'temperate' case with present-day boundary conditions and a generic future 'glacial' case with an ice sheet covering the repository. The results were summarized in the form of analyses of flow in and out from open tunnels, the effect on hydraulic head and flow in the surrounding rock volume, and transport performance measures of flow paths from the repository to surface

  1. Application of Stochastic Partial Differential Equations to Reservoir Property Modelling

    KAUST Repository

    Potsepaev, R.

    2010-09-06

    Existing algorithms of geostatistics for stochastic modelling of reservoir parameters require a mapping (the \\'uvt-transform\\') into the parametric space and reconstruction of a stratigraphic co-ordinate system. The parametric space can be considered to represent a pre-deformed and pre-faulted depositional environment. Existing approximations of this mapping in many cases cause significant distortions to the correlation distances. In this work we propose a coordinate free approach for modelling stochastic textures through the application of stochastic partial differential equations. By avoiding the construction of a uvt-transform and stratigraphic coordinates, one can generate realizations directly in the physical space in the presence of deformations and faults. In particular the solution of the modified Helmholtz equation driven by Gaussian white noise is a zero mean Gaussian stationary random field with exponential correlation function (in 3-D). This equation can be used to generate realizations in parametric space. In order to sample in physical space we introduce a stochastic elliptic PDE with tensor coefficients, where the tensor is related to correlation anisotropy and its variation is physical space.

  2. Investigation of Brain Arterial Circle Malformations Using Electrical Modelling and Simulation

    Directory of Open Access Journals (Sweden)

    Klara Capova

    2006-01-01

    Full Text Available The paper deals with the cerebral arterial system investigation by means of electrical modelling and simulations. The main attention is paid to the brain arterial circle malformations (stenoses and aneurysms and their determination and evaluation by computer-aided methods as tools of a non-invasive diagnostics. The compensation possibilities of brain arterial circle in case of presence of concrete arterial malformations are modelled and simulated. The simulation results of brain arteries blood pressures and volume flow velocities time dependences are presented and discussed under various health conditions.

  3. Impact of arterial occlusion during partial nephrectomy on residual renal function. An evaluation with {sup 99m}technetium-dimercaptosuccinic acid scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Kondo, Tsunenori; Nakazawa, Hayakazu; Ito, Fumio; Onitsuka, Shiro; Ryoji, Osamu; Yago, Rie; Hashimoto, Yasunobu; Toma, Hiroshi [Tokyo Women' s Medical Coll. (Japan)

    2002-08-01

    Partial nephrectomy (PNx) has been performed with temporary renal arterial occlusion and in situ renal hypothermia (conventional PNx). However, the impact of temporary renal arterial occlusion on residual renal function has not been well assessed. To address this question, we performed renal scintigraphy with {sup 99m}technetium-dimercaptosuccinic acid (DMSA) for the quantitative measurement of postoperative residual renal function after conventional PNx and partial nephrectomy without arterial occlusion (non-clamping PNx). Thirty-four patients underwent postoperative DMSA scintigraphy after PNx for renal cell carcinoma. No obvious difference in preoperative renal function between the diseased kidney and the contralateral kidney was found in any of the patients. Of these patients, 24 underwent conventional PNx, and 10 underwent non-clamping PNx. Residual renal function was evaluated using the relative DMSA uptake of the operated kidney. The relative DMSA uptake of the operated kidney was 39.9{+-}7.3% (25.1-58.8) after conventional PNx compared to 34.8{+-}8.9% (13.5-45.5) after non-clamping PNx. This difference was not statistically significant (P=0.15). Total ischemic time during conventional PNx had no adverse influence on the residual renal function. In the analysis of the other determinant factors influencing residual renal function, tumor size was the only significant factor that inversely correlated with the relative DMSA uptake. Our results showed that arterial clamping during PNx has no negative impact on the functional residual capacity as long as in situ renal hypothermia is adequately performed. (author)

  4. Plasticity in breathing and arterial blood pressure following acute intermittent hypercapnic hypoxia in infant rat pups with a partial loss of 5-HT neurons.

    Science.gov (United States)

    Magnusson, Jennifer; Cummings, Kevin J

    2015-11-15

    The role of serotonin (5-HT) neurons in cardiovascular responses to acute intermittent hypoxia (AIH) has not been studied in the neonatal period. We hypothesized that a partial loss of 5-HT neurons would reduce arterial blood pressure (BP) at rest, increase the fall in BP during hypoxia, and reduce the long-term facilitation of breathing (vLTF) and BP following AIH. We exposed 2-wk-old, 5,7-dihydroxytryptamine-treated and controls to AIH (10% O2; n = 13 control, 14 treated), acute intermittent hypercapnia (5% CO2; n = 12 and 11), or acute intermittent hypercapnic hypoxia (AIHH; 10% O2, 5% CO2; n = 15 and 17). We gave five 5-min challenges of AIH and acute intermittent hypercapnia, and twenty ∼20-s challenges of AIHH to mimic sleep apnea. Systolic BP (sBP), diastolic BP, mean arterial pressure, heart rate (HR), ventilation (V̇e), and metabolic rate (V̇o2) were continuously monitored. 5,7-Dihydroxytryptamine induced an ∼35% loss of 5-HT neurons from the medullary raphe. Compared with controls, pups deficient in 5-HT neurons had reduced resting sBP (∼6 mmHg), mean arterial pressure (∼5 mmHg), and HR (56 beats/min), and experienced a reduced drop in BP during hypoxia. AIHH induced vLTF in both groups, reflected in increased V̇e and V̇e/V̇o2, and decreased arterial Pco2. The sBP of pups deficient in 5-HT neurons, but not controls, was increased 1 h following AIHH. Our data suggest that a relatively small loss of 5-HT neurons compromises resting BP and HR, but has no influence on ventilatory plasticity induced by AIHH. AIHH may be useful for reversing cardiorespiratory defects related to partial 5-HT system dysfunction.

  5. Permintaan Beras di Provinsi Jambi (Penerapan Partial Adjustment Model

    Directory of Open Access Journals (Sweden)

    Wasi Riyanto

    2013-07-01

    Full Text Available The purpose of this study is to determine the effect of price of rice, flour prices, population, income of population and demand of rice for a year earlier on rice demand, demand rice elasticity and rice demand prediction in Jambi Province. This study uses secondary data, including time series data for 22 years from 1988 until 2009. The study used some variables, consist of rice demand (Qdt, the price of rice (Hb, the price of wheat flour (Hg, population (Jp, the income of the population (PDRB and demand for rice the previous year (Qdt-1. The make of this study are multiple regression and dynamic analysis  a Partial Adjustment Model, where the demand for rice is the dependent variable and the price of rice, flour prices, population, income population and demand of rice last year was the independent variable. Partial Adjustment Model analysis results showed that the effect of changes in prices of rice  and flour are not significant  to  changes in demand for rice. The population and demand of rice the previous year has positive and significant impact on demand for rice, while revenues have negative and significant population of rice demand. Variable price of rice, earning population and the price of flour is inelastic the demand of rice, because rice is not a normal good but as a necessity so that there is no substitution of goods (replacement of rice with other commodities in Jambi Province. Based on the analysis, it is recommended to the government to be able to control the rate of population increase given the variable number of people as one of the factors that affect demand for rice.It is expected that the  government also began  to  socialize  in a lifestyle  of  non-rice food consumption to control the increasing amount of demand for rice. Last suggestion, the government developed a diversification of staple foods other than rice. Keywords: Demand, Rice, Income Population

  6. A model of blood flow in the mesenteric arterial system

    Directory of Open Access Journals (Sweden)

    Cheng Leo K

    2007-05-01

    Full Text Available Abstract Background There are some early clinical indicators of cardiac ischemia, most notably a change in a person's electrocardiogram. Less well understood, but potentially just as dangerous, is ischemia that develops in the gastrointestinal system. Such ischemia is difficult to diagnose without angiography (an invasive and time-consuming procedure mainly due to the highly unspecific nature of the disease. Understanding how perfusion is affected during ischemic conditions can be a useful clinical tool which can help clinicians during the diagnosis process. As a first step towards this final goal, a computational model of the gastrointestinal system has been developed and used to simulate realistic blood flow during normal conditions. Methods An anatomically and biophysically based model of the major mesenteric arteries has been developed to be used to simulate normal blood flows. The computational mesh used for the simulations has been generated using data from the Visible Human project. The 3D Navier-Stokes equations that govern flow within this mesh have been simplified to an efficient 1D scheme. This scheme, together with a constitutive pressure-radius relationship, has been solved numerically for pressure, vessel radius and velocity for the entire mesenteric arterial network. Results The computational model developed shows close agreement with physiologically realistic geometries other researchers have recorded in vivo. Using this model as a framework, results were analyzed for the four distinct phases of the cardiac cycle – diastole, isovolumic contraction, ejection and isovolumic relaxation. Profiles showing the temporally varying pressure and velocity for a periodic input varying between 10.2 kPa (77 mmHg and 14.6 kPa (110 mmHg at the abdominal aorta are presented. An analytical solution has been developed to model blood flow in tapering vessels and when compared with the numerical solution, showed excellent agreement. Conclusion An

  7. Arterial Calcification in Diabetes Mellitus: Preclinical Models and Translational Implications.

    Science.gov (United States)

    Stabley, John N; Towler, Dwight A

    2017-02-01

    Diabetes mellitus increasingly afflicts our aging and dysmetabolic population. Type 2 diabetes mellitus and the antecedent metabolic syndrome represent the vast majority of the disease burden-increasingly prevalent in children and older adults. However, type 1 diabetes mellitus is also advancing in preadolescent children. As such, a crushing wave of cardiometabolic disease burden now faces our society. Arteriosclerotic calcification is increased in metabolic syndrome, type 2 diabetes mellitus, and type 1 diabetes mellitus-impairing conduit vessel compliance and function, thereby increasing the risk for dementia, stroke, heart attack, limb ischemia, renal insufficiency, and lower extremity amputation. Preclinical models of these dysmetabolic settings have provided insights into the pathobiology of arterial calcification. Osteochondrogenic morphogens in the BMP-Wnt signaling relay and transcriptional regulatory programs driven by Msx and Runx gene families are entrained to innate immune responses-responses activated by the dysmetabolic state-to direct arterial matrix deposition and mineralization. Recent studies implicate the endothelial-mesenchymal transition in contributing to the phenotypic drift of mineralizing vascular progenitors. In this brief overview, we discuss preclinical disease models that provide mechanistic insights-and point to challenges and opportunities to translate these insights into new therapeutic strategies for our patients afflicted with diabetes mellitus and its arteriosclerotic complications. © 2016 American Heart Association, Inc.

  8. Estimation of arterial PCO2 from a lung model during ramp exercise in healthy young subjects.

    Science.gov (United States)

    Thomas, Vincent; Costes, Frédéric; Busso, Thierry

    2007-06-15

    The aim of this study is to propose a new approach to estimate non-invasively arterial carbon dioxide partial pressure (P(a)CO2) approach was based on the reconstruction of alveolar gas composition over each breath from a tidally ventilated lung model (P(M)(CO2)). Eight healthy young subjects were studied during a ramp exercise test on a cycle ergometer. Arterial samples were drawn at rest and every minute during the exercise test for determination of P(a)CO2 . P(a)CO2 was compared with indirect estimates of P(CO2) : P(M)(CO2), end-tidal P(CO2) (P(ET)(CO2)) and an empirical equation involving P(ET)(CO2) and tidal volume (P(J)(CO2)). The difference between estimated and measured P(a)CO2 on the whole ramp exercise was -0.3+/-1.9mmHg for P(M)(CO2), 1.0+/-2.2mmHg for P(ET)(CO2) and -1.7+/-1.7mmHg for P(J)(CO2) . P(ET)(CO2) and P(J)(CO2) were significantly different from actual P(a)CO2 (P<0.001). It is concluded that, on the basis of the bias, the breathing lung model gave better estimates of P(a)CO2 than the two other indirect methods during ramp exercise.

  9. Model Validation for a Noninvasive Arterial Stenosis Detection Problem

    Science.gov (United States)

    2013-06-09

    Diastolic murmur caused by coronary artery stenosis , Ann. Int. Med, 72 (1970), 543. [33] T. Deffieux, G. Montaldo, M. Tanter, Shear wave spectroscopy for...Circulation, 103 (2001), 604–616. [45] N. Owsley and A. Hull, Beamformed nearfield imaging of a simulated coronary artery containing a stenosis , IEEE...murmur of coronary artery stenosis , Brit. Heart J., 35 (1973), 840. [53] J. Semmlow and K. Rahalkar, Acoustic detection of coronary artery disease, Annu

  10. Hemocoagulase atrox reduces vascular modeling in rabbit carotid artery adventitia

    Science.gov (United States)

    Wan, Sheng-Yun; Hu, Yuan-Cheng; Zhan, Yan-Qing; Qin, Dan-Dan; Ding, Yang

    2013-01-01

    Objective: This study aimed to compare the effects of hemocoagulase atrox and cauterization hemostasis on intimal hyperplasia and explore the effect of hemocoagulase atrox on vascular modeling in rabbit carotid artery adventitia. Methods: A total of 27 rabbits were randomly divided into 3 groups (0d, 14d, 28d). They were anaesthetized using an intramuscular injection of phenobarbital sodium (1 ml/kg). The left and right common carotid arteries were exposed and capillary hemorrhaged after blunt dissection of the adventitia layers of common carotid arteries. Nine rabbits in each group were again randomly divided into 3 groups, in which animals were respectively treated with hemocoagulase (2 U/ml), cauterization (power = 40 w) and saline (as control). Groups of animals were euthanized at 0, 14 and 28 days after surgery. The samples were equally divided in the middle of the adventitia removal section to obtain equal parts for histologic, immunohistochemical and molecular biologic analysis. The vascular repair after adventitial stripping was observed by HE staining, Masson staining and transmission electron microscopy. The expression of carotid MCP-1, PCNA, TGF-β1, α-SMA and VEGF were measured at different time points by RT-PCR and immunohistochemical staining. Results: HE staining and Masson staining showed that hemocoagulase atrox had a significantly stronger effect on reducing intimal hyperplasia than the cauterization after 14 and 28 days. The results of RT-PCR showed that the expression of MCP-1, TGF-β1, α-SMA and VEGF in hemocoagulase atrox-treated animals were lower than that of cauterization-treated animals. Conclusion: Our results suggested that hemocoagulase atrox as a topical hemostatic is safety and efficiently and it can accelerate adventitia restoration and decrease intimal proliferation. PMID:24228100

  11. Reactor modeling and process analysis for partial oxidation of natural gas

    NARCIS (Netherlands)

    Albrecht, Bogdan Alexandru

    2004-01-01

    This thesis analyses a novel process of partial oxidation of natural gas and develops a numerical tool for the partial oxidation reactor modeling. The proposed process generates syngas in an integrated plant of a partial oxidation reactor, a syngas turbine and an air separation unit. This is called

  12. Circulação extracorpórea com desvio veno-arterial e baixa pressão parcial de oxigênio Extracorporeal circulation with venous-arterial shunt and low oxygen partial pressure

    Directory of Open Access Journals (Sweden)

    Mário Coli Junqueira de MORAES

    2001-09-01

    da perfusão. No estudo clínico verificou-se baixo pO2 arterial e fluxo de perfusão normal. Comparando-se os resultados clínicos constatou-se que não houve diferença de mortalidade nos 2 grupos, porém no grupo com baixo pO2 e desvio veno-arterial o sangramento pós-operatório foi significativamente menor, utilizando-se três vezes menos hemoderivados. Além disso, não foi necessário o uso de misturador de gases.PURPOSE: This study is divided into 2 parts, an experimental study to establish a technique of extracorporeal circulation with low oxygen partial pressure and a clinical study to show the feasibility in humans. MATERIAL AND METHODS: Experimental surgery with extracorporeal circulation was performed in 20 dogs divided into 2 groups of ten. In group I, cannulation was done first in the superior vena cava, then in the inferior vena cava, keeping normal heartbeat and breathing, controlled by a respirator and pure oxygen. After passing through a heat exchanger, the blood of each vena cava was injected in the femoral artery. Blood samples from the aorta were taken above the diaphragm in every 30 minutes to check gasometric values. In group II, the right atrium was drained and half of the blood injected in the pulmonary artery with another pump and picked up through the left ventricle to the reservoir that also works as a heat exchanger. The mixed blood (50% arterial and 50% venous was re-injected by another pump in the arterial circulation. The heart was maintained fibrillating and the breathing controlled by the respirator. In the clinical study, 40 patients were divided into 2 groups of 20 each. In group A the patients were bypassed in the conventional manner, that is, compressed air and oxygen in the oxigenator with high arterial pO2. In group B, pure oxygen was used in the membrane oxigenator and venous-arterial shunt, performed between 40% to 50%. RESULTS: In both groups, from a physiologic point of view there was shunting of 50% of venous blood to the

  13. Stochastic Modeling and Generation of Partially Polarized or Partially Coherent Electromagnetic Waves

    Science.gov (United States)

    Davis, Brynmor; Kim, Edward; Piepmeier, Jeffrey; Hildebrand, Peter H. (Technical Monitor)

    2001-01-01

    Many new Earth remote-sensing instruments are embracing both the advantages and added complexity that result from interferometric or fully polarimetric operation. To increase instrument understanding and functionality a model of the signals these instruments measure is presented. A stochastic model is used as it recognizes the non-deterministic nature of any real-world measurements while also providing a tractable mathematical framework. A stationary, Gaussian-distributed model structure is proposed. Temporal and spectral correlation measures provide a statistical description of the physical properties of coherence and polarization-state. From this relationship the model is mathematically defined. The model is shown to be unique for any set of physical parameters. A method of realizing the model (necessary for applications such as synthetic calibration-signal generation) is given and computer simulation results are presented. The signals are constructed using the output of a multi-input multi-output linear filter system, driven with white noise.

  14. An implicit solver for 1D arterial network models.

    Science.gov (United States)

    Carson, Jason; Van Loon, Raoul

    2017-07-01

    In this study, the 1D blood flow equations are solved using a newly proposed enhanced trapezoidal rule method (ETM), which is an extension to the simplified trapezoidal rule method. At vessel junctions, the conservation of mass and conservation of total pressure are held as system constraints using Lagrange multipliers that can be physically interpreted as external flow rates. The ETM scheme is compared with published arterial network benchmark problems and a dam break problem. Strengths of the ETM scheme include being simple to implement, intuitive connection to lumped parameter models, and no restrictive stability criteria such as the Courant-Friedrichs-Lewy (CFL) number. The ETM scheme does not require the use of characteristics at vessel junctions, or for inlet and outlet boundary conditions. The ETM forms an implicit system of equations, which requires only one global solve per time step for pressure, followed by flow rate update on the elemental system of equations; thus, no iterations are required per time step. Consistent results are found for all benchmark cases, and for a 56-vessel arterial network problem, it gives very satisfactory solutions at a spatial and time discretization that results in a maximum CFL of 3, taking 4.44 seconds per cardiac cycle. By increasing the time step and element size to produce a maximum CFL number of 15, the method takes only 0.39 second per cardiac cycle with only a small compromise on accuracy. Copyright © 2016 John Wiley & Sons, Ltd.

  15. Bayesian inference for partially identified models exploring the limits of limited data

    CERN Document Server

    Gustafson, Paul

    2015-01-01

    Introduction Identification What Is against Us? What Is for Us? Some Simple Examples of Partially Identified ModelsThe Road Ahead The Structure of Inference in Partially Identified Models Bayesian Inference The Structure of Posterior Distributions in PIMs Computational Strategies Strength of Bayesian Updating, Revisited Posterior MomentsCredible Intervals Evaluating the Worth of Inference Partial Identification versus Model Misspecification The Siren Call of Identification Comp

  16. Learning to Make Predictions In Partially Observable Environments Without a Generative Model

    OpenAIRE

    Talvitie, Erik; Singh, Satinder

    2014-01-01

    When faced with the problem of learning a model of a high-dimensional environment, a common approach is to limit the model to make only a restricted set of predictions, thereby simplifying the learning problem. These partial models may be directly useful for making decisions or may be combined together to form a more complete, structured model. However, in partially observable (non-Markov) environments, standard model-learning methods learn generative models, i.e. models that provide a probab...

  17. Modelling non-symmetric collagen fibre dispersion in arterial walls.

    Science.gov (United States)

    Holzapfel, Gerhard A; Niestrawska, Justyna A; Ogden, Ray W; Reinisch, Andreas J; Schriefl, Andreas J

    2015-05-06

    New experimental results on collagen fibre dispersion in human arterial layers have shown that the dispersion in the tangential plane is more significant than that out of plane. A rotationally symmetric dispersion model is not able to capture this distinction. For this reason, we introduce a new non-symmetric dispersion model, based on the bivariate von Mises distribution, which is used to construct a new structure tensor. The latter is incorporated in a strain-energy function that accommodates both the mechanical and structural features of the material, extending our rotationally symmetric dispersion model (Gasser et al. 2006 J. R. Soc. Interface 3, 15-35. (doi:10.1098/rsif.2005.0073)). We provide specific ranges for the dispersion parameters and show how previous models can be deduced as special cases. We also provide explicit expressions for the stress and elasticity tensors in the Lagrangian description that are needed for a finite-element implementation. Material and structural parameters were obtained by fitting predictions of the model to experimental data obtained from human abdominal aortic adventitia. In a finite-element example, we analyse the influence of the fibre dispersion on the homogeneous biaxial mechanical response of aortic strips, and in a final example the non-homogeneous stress distribution is obtained for circumferential and axial strips under fixed extension. It has recently become apparent that this more general model is needed for describing the mechanical behaviour of a variety of fibrous tissues.

  18. Partial Discharge in Capacitor Model at Low Temperature

    Directory of Open Access Journals (Sweden)

    P. Rain

    2009-01-01

    Full Text Available The partial discharge plays an important role in the ageing and the rupture process of solid or mixed insulation systems. Ithas been recognized that the failure of this insulation can be joined to the presence of partial discharge often in inclusionssparkling. Liquid filled cavities can be considered as the most likely defects that can exist in capacitors. In this paper wedescribe the partial discharge evolution at low temperatures in all-PP film capacitors according to the time and the appliedvoltage. We distinguish two regimes of discharges for all the range of temperature and the low temperatures encourage thebreakdown of capacitors at weak voltage, we assign this phenomenon to the increase of the viscosity of filling liquid.

  19. The alveolar to arterial oxygen partial pressure difference is associated with pulmonary diffusing capacity in heart failure patients.

    Science.gov (United States)

    Morosin, Marco; Vignati, Carlo; Novi, Angela; Salvioni, Elisabetta; Veglia, Fabrizio; Alimento, Marina; Merli, Guido; Sciomer, Susanna; Sinagra, Gianfranco; Agostoni, Piergiuseppe

    2016-11-01

    In chronic heart failure (HF), the alveolar-capillary membrane undergoes a remodeling process that negatively affects gas exchange. In case of alveolar-capillary gas diffusion impairment, arterial desaturation (SaO2) is rarely observed in HF patients. At play are 3 factors: overall pulmonary diffusing capacity (assessed as lung diffusion for CO, DLCO), global O2 consumption (VO2) and alveolar (A) to arterial (a) pO2 gradient (AaDO2). In 100 consecutive stable HF patients, DLCO, resting respiratory gases and arterial blood gases were measured to determine VO2, paO2, pAO2 and AaDO2. DLCO was poorly but significantly related to AaDO2. The correlation improved after correcting AaDO2 for VO2 (p<0.001, r=0.49). Both VO2 and AaDO2 were independently associated with DLCO (p<0.001). Patients with reduced DLCO showed no differences as regards paO2 and pAO2. AaDO2/VO2 showed a higher gradient in patients with lower DLCO. AaDO2 increase and VO2 reduction allow preventing low SaO2 in HF patients with reduced DLCO. Accordingly, we suggest considering AaDO2 and VO2 combined and reporting AaDO2/VO2. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. A surgical model of permanent and transient middle cerebral artery stroke in the sheep.

    Directory of Open Access Journals (Sweden)

    Adam J Wells

    Full Text Available BACKGROUND: Animal models are essential to study the pathophysiological changes associated with focal occlusive stroke and to investigate novel therapies. Currently used rodent models have yielded little clinical success, however large animal models may provide a more suitable alternative to improve clinical translation. We sought to develop a model of acute proximal middle cerebral artery (MCA ischemic stroke in sheep, including both permanent occlusion and transient occlusion with reperfusion. MATERIALS AND METHODS: 18 adult male and female Merino sheep were randomly allocated to one of three groups (n = 6/gp: 1 sham surgery; 2 permanent proximal MCA occlusion (MCAO; or 3 temporary MCAO with aneurysm clip. All animals had invasive arterial blood pressure, intracranial pressure and brain tissue oxygen monitoring. At 4 h following vessel occlusion or sham surgery animals were killed by perfusion fixation. Brains were processed for histopathological examination and infarct area determination. 6 further animals were randomized to either permanent (n = 3 or temporary MCAO (n = 3 and then had magnetic resonance imaging (MRI at 4 h after MCAO. RESULTS: Evidence of ischemic injury in an MCA distribution was seen in all stroke animals. The ischemic lesion area was significantly larger after permanent (28.8% compared with temporary MCAO (14.6%. Sham animals demonstrated no evidence of ischemic injury. There was a significant reduction in brain tissue oxygen partial pressure after permanent vessel occlusion between 30 and 210 mins after MCAO. MRI at 4 h demonstrated complete proximal MCA occlusion in the permanent MCAO animals with a diffusion deficit involving the whole right MCA territory, whereas temporary MCAO animals demonstrated MRA evidence of flow within the right MCA and smaller predominantly cortical diffusion deficits. CONCLUSIONS: Proximal MCAO can be achieved in an ovine model of stroke via a surgical approach. Permanent

  1. Adaptive Partially Hidden Markov Models with Application to Bilevel Image Coding

    DEFF Research Database (Denmark)

    Forchhammer, Søren Otto; Rasmussen, Tage

    1999-01-01

    Adaptive Partially Hidden Markov Models (APHMM) are introduced extending the PHMM models. The new models are applied to lossless coding of bi-level images achieving resluts which are better the JBIG standard.......Adaptive Partially Hidden Markov Models (APHMM) are introduced extending the PHMM models. The new models are applied to lossless coding of bi-level images achieving resluts which are better the JBIG standard....

  2. On models for continuous facility location with partial coverage

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Körner, Mark-Christoph

    2014-01-01

    This paper presents a new concept of partial coverage distance, where demand points within a given threshold distance of a new facility are covered in the traditional sense, while non-covered demand points are penalized an amount proportional to their distance to the covered region. Two single fa...

  3. Automated computational modelling for complicated partial differential equations

    NARCIS (Netherlands)

    Ølgaard, K.B.

    2013-01-01

    In engineering, physical phenomena are often described mathematically by partial differential equations (PDEs), and a commonly used method to solve these equations is the finite element method (FEM). Implementing a solver based on this method for a given PDE in a computer program written in source c

  4. Micromechanical modelling of partially molten and sand reinforced polycrystalline ice

    Science.gov (United States)

    Castelnau, O.; Duval, P.

    2009-12-01

    The viscoplastic behaviour of polycrystalline ice is strongly affected by the very strong anisotropy of ice crystals. Indeed, in the dislocations creep regime relevant for ice sheet flow, dislocation glide on the basal plane of ice single crystals leads to strain-rates ~6 order of magnitude larger than strain-rates that might be obtain if only non-basal glide is activated. At the polycrystal scale, this behaviour is responsible for a strong mechanical interaction between grains in the secondary (stationary) creep regime, and strain-rate is essentially partitioned between soft grains well-oriented for basal glide and hard grains exhibiting an unfavourable orientation for basal slip. As a consequence, the macroscopic flow stress at the polycrystal scale essentially depends on the resistance of the hardest slip systems or on the associated accommodation processes such as climb of basal dislocation on non-basal planes. Creep experiments performed on polycrystalline ices containing a small amount (less than 10% volume fraction) of liquid water show a dramatic increase of strain-rate, by more than one order of magnitude, compared to solid ice when deformed under similar thermo-mechanical conditions. Similarly, a strong hardening is observed when polycrystalline ice is reinforced by sand (which can be considered as a rigid phase here). This behaviour can be explained by micromechanical models, which aims at estimating the mechanical interactions between grains. For example, the presence of water releases stress concentrations at grain boundaries and therefore favours the inactivation of non-basal systems. To estimate such effect and to reach quantitative comparison with experimental data, we make use of the recent Second-Order homogenization mean-field approach of Ponte-Castaneda, based on self-consistent scheme. The advantage of this approach, which has been shown to provide excellent results when applied to many different non-linear composite materials, comes from the

  5. In vitro model of platelet aggregation in stenotic arteries

    Energy Technology Data Exchange (ETDEWEB)

    Morley, D.; Santamore, W.P.

    1988-07-01

    Clinical and experimental evidence suggest a strong relationship between arterial stenosis, platelet aggregation, and subsequent thrombus formation. To facilitate the study of platelet accumulation in stenotic arteries, we developed an in vitro preparation. Arterial segments were perfused with whole citrated blood. A stenosis was created by applying an external plastic constrictor to the artery. Platelet accumulation within the stenosis was assessed by scanning electron microscopy and by radioactive counts from Indium-111 labeled platelets. Utilizing this preparation, 30 carotid arterial segments from 10 mongrel dogs were perfused at 100 mmHg for 15 min. In 10 arteries without a stenosis, scanning electron microscopy and radioactive counts demonstrated little platelet accumulation. In contrast, extensive platelet aggregation was observed in 10 arteries with stenoses. Moreover, in 10 stenotic arteries exposed to the thromboxane mimetic, U46619 (Upjohn Diagnostic Group), scanning electron microscopy and radioactive counts demonstrated a significant increase in platelet deposition. Conversely, we demonstrated a dimunition of platelet accumulation in stenosed arterial segments exposed to the prostacyclin analogue platelet inhibitor, Iloprost. The in vitro preparation allows precise control of hemodynamic variables and makes it possible to perform multiple tests on segments of the same vessel from the same animal.

  6. Necessary and Sufficient Conditions on Partial Orders for Modeling Concurrent Computations

    OpenAIRE

    Chauhan, Himanshu; Vijay K Garg

    2014-01-01

    Partial orders are used extensively for modeling and analyzing concurrent computations. In this paper, we define two properties of partially ordered sets: width-extensibility and interleaving-consistency, and show that a partial order can be a valid state based model: (1) of some synchronous concurrent computation iff it is width-extensible, and (2) of some asynchronous concurrent computation iff it is width-extensible and interleaving-consistent. We also show a duality between the event base...

  7. 原位肾低温灌注腹腔镜下肾部分切除术%Laparoscopic partial nephrectomy with hypothermic renal artery perfusion in situ

    Institute of Scientific and Technical Information of China (English)

    李汉忠; 董德鑫; 严维刚; 张玉石

    2010-01-01

    Objective To study a modified method of laparoscopic partial nephrectomy with hypothermic renal artery perfusion in situ.Methods Laparoscopic partial nephrectomy with hypothermic renal artery perfusion in situ was performed in 5 patients from March 2009 to May 2009.There were 3 males and 2 females,with an average age of 49 years (39 to 63 years).There were 3 tumors in the left kidney and 2 in the right kidney,with an average diameter of 5.6 cm (range,3.8 to 7.0 cm).There were 2 cases of chronic renal insufficiency,1 case of solitary kidney,1 case of contralateral renal atrophy and 1 case of larger benign tumor.The procedure of laparoscopic partial nephrectomy with hypothermic renal artery perfusion in situ was as follows:A catheter with balloon was placed in the renal artery with percutaneous approach through the femoral artery preoperatively.During the operation the balloon of the catheter was inflated with water in order to block the renal artery,and renal artery perfusion of about 200ml saline of 4 ℃ was conducted through the catheter under high pressure in order to achieve low temperature in situ kidney.The water of the balloon was extracted after the accomplishment of the laparoscopic partial nephrectomy.Results Laparoscopic partial nephrectomies with hypothermic renal artery perfusion in situ were carried out successfully in 5 cases.The average operative time was 102 min (80 to 120 min),the average renal artery occlusion time was 35 min (range,29 to 39 min),and the average amount of bleeding was 190 ml(50 to 300 ml).The temperature of skin,kidneys,and tumor after hypothermic perfusion dropped by an average of 0.6℃,10.0 ℃,and 9.8℃,respectively.The endogenous creatinine clearance rate was(84.7±16.9),(48.9±14.5),(52.1±12.4),(54.5±13.8),and(54.6±11.7)ml/min before and 1 day,3 days,5 days and 10 days after operation.There was significant difference among the 5 groups in endogenous creatinine clearance rate(P=0.001).There was significant difference

  8. Characterization of partial ligation-induced carotid atherosclerosis model using dual-modality molecular imaging in ApoE knock-out mice.

    Directory of Open Access Journals (Sweden)

    Ik Jae Shin

    Full Text Available BACKGROUND: Recently, partial ligation of the common carotid artery (CCA was reported to induce carotid atheromata rapidly in apolipoprotein-E knockout (ApoE(-/- mice. We investigated this new atherosclerosis model by using combined matrix-metalloproteinase (MMP near-infrared fluorescent (NIRF imaging and macrophage-tracking luciferase imaging. METHODOLOGY AND PRINCIPAL FINDINGS: Partial ligation of the left CCA was performed in 10-week-old ApoE(-/- mice on a high fat diet (n=33; the internal and external carotid arteries and occipital artery were ligated, while the superior thyroid artery was left intact. Two thirds of the animals were treated with either LiCl or atorvastatin. At 1-week, Raw264.7 macrophages modified to express the enhanced firefly-luciferase reporter gene (10(7 Raw-luc cells were injected intravenously. At 2-week, NIRF molecular imaging visualized strong MMP-2/9 activity in the ligated area of the left CCA as well as in the aortic arch. Left-to-right ratios of the NIRF signal intensities in the CCA had a decreasing gradient from the highest value in the upper-most ligated area to the lowest value in the lower-most region adjacent to the aortic arch. Luciferase imaging showed that most Raw-luc macrophages were recruited to the ligated area of the CCA rather than to the aortic arch, despite similarly strong MMP-2/9-related NIRF signal intensities in both areas. In addition, LiCl or atorvastatin could reduce MMP-2/9 activity in the aortic arch but not in the ligated area of the CCA. CONCLUSIONS/SIGNIFICANCE: This is the first molecular imaging study to characterize the partial ligation-induced carotid atherosclerosis model. Molecularly divergent types of atherosclerosis were identified: conventional lipogenic atherosclerosis in the aorta vs. flow-related mechanical atherosclerosis in the partially ligated left system.

  9. Ultrasound Common Carotid Artery Segmentation Based on Active Shape Model

    Directory of Open Access Journals (Sweden)

    Xin Yang

    2013-01-01

    Full Text Available Carotid atherosclerosis is a major reason of stroke, a leading cause of death and disability. In this paper, a segmentation method based on Active Shape Model (ASM is developed and evaluated to outline common carotid artery (CCA for carotid atherosclerosis computer-aided evaluation and diagnosis. The proposed method is used to segment both media-adventitia-boundary (MAB and lumen-intima-boundary (LIB on transverse views slices from three-dimensional ultrasound (3D US images. The data set consists of sixty-eight, 17 × 2 × 2, 3D US volume data acquired from the left and right carotid arteries of seventeen patients (eight treated with 80 mg atorvastatin and nine with placebo, who had carotid stenosis of 60% or more, at baseline and after three months of treatment. Manually outlined boundaries by expert are adopted as the ground truth for evaluation. For the MAB and LIB segmentations, respectively, the algorithm yielded Dice Similarity Coefficient (DSC of 94.4% ± 3.2% and 92.8% ± 3.3%, mean absolute distances (MAD of 0.26 ± 0.18 mm and 0.33 ± 0.21 mm, and maximum absolute distances (MAXD of 0.75 ± 0.46 mm and 0.84 ± 0.39 mm. It took 4.3 ± 0.5 mins to segment single 3D US images, while it took 11.7 ± 1.2 mins for manual segmentation. The method would promote the translation of carotid 3D US to clinical care for the monitoring of the atherosclerotic disease progression and regression.

  10. 24 CFR 200.926c - Model code provisions for use in partially accepted code jurisdictions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Model code provisions for use in partially accepted code jurisdictions. 200.926c Section 200.926c Housing and Urban Development Regulations... Minimum Property Standards § 200.926c Model code provisions for use in partially accepted...

  11. Automatic segmentation of vertebral arteries in CT angiography using combined circular and cylindrical model fitting

    Science.gov (United States)

    Lee, Min Jin; Hong, Helen; Chung, Jin Wook

    2014-03-01

    We propose an automatic vessel segmentation method of vertebral arteries in CT angiography using combined circular and cylindrical model fitting. First, to generate multi-segmented volumes, whole volume is automatically divided into four segments by anatomical properties of bone structures along z-axis of head and neck. To define an optimal volume circumscribing vertebral arteries, anterior-posterior bounding and side boundaries are defined as initial extracted vessel region. Second, the initial vessel candidates are tracked using circular model fitting. Since boundaries of the vertebral arteries are ambiguous in case the arteries pass through the transverse foramen in the cervical vertebra, the circle model is extended along z-axis to cylinder model for considering additional vessel information of neighboring slices. Finally, the boundaries of the vertebral arteries are detected using graph-cut optimization. From the experiments, the proposed method provides accurate results without bone artifacts and eroded vessels in the cervical vertebra.

  12. Research on the Optical Properties of Transformers Partial Discharge Based on Different Discharge Models

    Directory of Open Access Journals (Sweden)

    Wei Bengang

    2016-01-01

    Full Text Available In this paper, the different types of discharge in transformer were simulated based on the real transformer fault model. The optical partial discharge detection system was established based on optical sensors which were capturing partial discharge accompanied by optical effects. In this research, surface discharge and suspended discharge defect model was pressurized to generate partial discharge signal. The results showed that: Partial discharge optical signals could effectively respond the production and development process of transformer partial discharge. It was able to assess discharge level also. When the discharge phenomenon stabilized, the phase of surface discharge mainly between 60°~150°and 240°~330°, the phase of suspended discharge mainly between 260°~320°. According to the phase characteristic of discharge pattern, the creeping discharge and suspended discharge phenomenon of transformer can be distinguished. It laid the foundation for the application of transformer optical partial discharge detection technology.

  13. Partial Conservation Law in a Schematic Single j Shell Model

    CERN Document Server

    Pereira, Wesley; Zamick, Larry; Escuderos, Alberto; Neergård, Kai

    2016-01-01

    We report the discovery of a partial conservation law obeyed by a schematic Hamiltonian of two protons and two neutrons in a j shell. In our Hamiltonian the interaction matrix element of two nucleons with combined angular momentum J is linear in J for even J and constant for odd J. It turns out that in some stationary states the sum J_p + J_n of the angular momenta J_p and J_n of the proton and neutron pairs is conserved. The energies of these states are given by a linear function of J_p + J_n. The systematics of their occurrence is described and explained.

  14. Characterisation of a novel porcine coronary artery CTO model.

    Science.gov (United States)

    Fefer, Paul; Robert, Normand; Qiang, Beiping; Liu, Garry; Munce, Nigel; Anderson, Kevan; Osherov, Azriel B; Ladouceur-Wodzak, Michelle; Qi, Xiuling; Dick, Alexander; Weisbrod, Max; Samuel, Michelle; Butany, Jagdish; Wright, Graham; Strauss, Bradley H

    2012-04-01

    To create a large animal coronary chronic total occlusion (CTO) model. Presence of microvessels within the CTO lumen facilitates guidewire crossing. The patterns and time profiles of matrix changes and microvessel formation during coronary CTO maturation are unknown. CTO were created in 15 swine by percutaneous deployment of a collagen plug. Matrix changes were assessed by histology. Intraluminal neovascularisation was assessed by histology and several imaging modalities, including conventional and 3D spin angiography, micro-computed tomography (micro-CT) imaging, and contrast-enhanced magnetic resonance imaging (MRI), at six and 12 weeks following CTO creation. Matrix changes included an intense inflammatory reaction at six weeks which had partially abated by 12 weeks. A proteoglycan-rich matrix at six weeks was partially replaced with collagen by 12 weeks. Similar changes were noted in the proximal cap which was acellular. Three patterns of microvessel formation were identified and defined based on the presence and extent of a "lead" neovessel. No major differences in pattern or extent of neovascularisation were noted between six and 12 weeks. Heterogeneity in neovascularisation patterns occurs during coronary CTO development in a porcine model. Non-invasive imaging to determine the predominant type of neovascularisation prior to and during CTO revascularisation may improve guidewire crossing success rates. This model may be useful for further exploration of CTO pathophysiology, and may aid in further refinements of in vivo imaging of CTO and development of novel therapeutic approaches to revascularisation of CTO, such as manipulations of the proximal cap, matrix composition, neovessel induction, and device testing.

  15. Propagation of partially polarized Gaussian Schell-model beams through aligned and misaligned optical systems

    Institute of Scientific and Technical Information of China (English)

    戈迪; 蔡阳健; 林强

    2005-01-01

    By use of a tensor method, the transform formulae for the beam coherence-polarization matrix of the partially polarized Gaussian Schell-model (GSM) beams through aligned and misaligned optical systems are derived. As an example, the propagation properties of the partially polarized GSM beam passing through a misaligned thin lens are illustrated numerically and discussed in detail. The derived formulae provide a convenient way to study the propagation properties of the partially polarized GSM beams through aligned and misaligned optical systems.

  16. Modeling Fatty Acid Transfer from Artery to Cardiomyocyte.

    Science.gov (United States)

    Arts, Theo; Reneman, Robert S; Bassingthwaighte, James B; van der Vusse, Ger J

    2015-12-01

    Despite the importance of oxidation of blood-borne long-chain fatty acids (Fa) in the cardiomyocytes for contractile energy of the heart, the mechanisms underlying the transfer of Fa from the coronary plasma to the cardiomyocyte is still incompletely understood. To obtain detailed insight into this transfer process, we designed a novel model of Fa transfer dynamics from coronary plasma through the endothelial cells and interstitium to the cardiomyocyte, applying standard physicochemical principles on diffusion and on the chemical equilibrium of Fa binding to carrier proteins Cp, like albumin in plasma and interstitium and Fatty Acid-Binding Proteins within endothelium and cardiomyocytes. Applying these principles, the present model strongly suggests that in the heart, binding and release of Fa to and from Cp in the aqueous border zones on both sides of the cell membranes form the major hindrance to Fa transfer. Although often considered, the membrane itself appears not to be a significant hindrance to diffusion of Fa. Proteins, residing in the cellular membrane, may facilitate transfer of Fa between Cp and membrane. The model is suited to simulate multiple tracer dilution experiments performed on isolated rabbit hearts administrating albumin and Fa as tracer substances into the coronary arterial perfusion line. Using parameter values on myocardial ultrastructure and physicochemical properties of Fa and Cp as reported in literature, simulated washout curves appear to be similar to the experimentally determined ones. We conclude therefore that the model is realistic and, hence, can be considered as a useful tool to better understand Fa transfer by evaluation of experimentally determined tracer washout curves.

  17. Modeling Fatty Acid Transfer from Artery to Cardiomyocyte.

    Directory of Open Access Journals (Sweden)

    Theo Arts

    2015-12-01

    Full Text Available Despite the importance of oxidation of blood-borne long-chain fatty acids (Fa in the cardiomyocytes for contractile energy of the heart, the mechanisms underlying the transfer of Fa from the coronary plasma to the cardiomyocyte is still incompletely understood. To obtain detailed insight into this transfer process, we designed a novel model of Fa transfer dynamics from coronary plasma through the endothelial cells and interstitium to the cardiomyocyte, applying standard physicochemical principles on diffusion and on the chemical equilibrium of Fa binding to carrier proteins Cp, like albumin in plasma and interstitium and Fatty Acid-Binding Proteins within endothelium and cardiomyocytes. Applying these principles, the present model strongly suggests that in the heart, binding and release of Fa to and from Cp in the aqueous border zones on both sides of the cell membranes form the major hindrance to Fa transfer. Although often considered, the membrane itself appears not to be a significant hindrance to diffusion of Fa. Proteins, residing in the cellular membrane, may facilitate transfer of Fa between Cp and membrane. The model is suited to simulate multiple tracer dilution experiments performed on isolated rabbit hearts administrating albumin and Fa as tracer substances into the coronary arterial perfusion line. Using parameter values on myocardial ultrastructure and physicochemical properties of Fa and Cp as reported in literature, simulated washout curves appear to be similar to the experimentally determined ones. We conclude therefore that the model is realistic and, hence, can be considered as a useful tool to better understand Fa transfer by evaluation of experimentally determined tracer washout curves.

  18. Modeling Fatty Acid Transfer from Artery to Cardiomyocyte

    Science.gov (United States)

    Arts, Theo; Reneman, Robert S.; Bassingthwaighte, James B.; van der Vusse, Ger J.

    2015-01-01

    Despite the importance of oxidation of blood-borne long-chain fatty acids (Fa) in the cardiomyocytes for contractile energy of the heart, the mechanisms underlying the transfer of Fa from the coronary plasma to the cardiomyocyte is still incompletely understood. To obtain detailed insight into this transfer process, we designed a novel model of Fa transfer dynamics from coronary plasma through the endothelial cells and interstitium to the cardiomyocyte, applying standard physicochemical principles on diffusion and on the chemical equilibrium of Fa binding to carrier proteins Cp, like albumin in plasma and interstitium and Fatty Acid-Binding Proteins within endothelium and cardiomyocytes. Applying these principles, the present model strongly suggests that in the heart, binding and release of Fa to and from Cp in the aqueous border zones on both sides of the cell membranes form the major hindrance to Fa transfer. Although often considered, the membrane itself appears not to be a significant hindrance to diffusion of Fa. Proteins, residing in the cellular membrane, may facilitate transfer of Fa between Cp and membrane. The model is suited to simulate multiple tracer dilution experiments performed on isolated rabbit hearts administrating albumin and Fa as tracer substances into the coronary arterial perfusion line. Using parameter values on myocardial ultrastructure and physicochemical properties of Fa and Cp as reported in literature, simulated washout curves appear to be similar to the experimentally determined ones. We conclude therefore that the model is realistic and, hence, can be considered as a useful tool to better understand Fa transfer by evaluation of experimentally determined tracer washout curves. PMID:26675003

  19. Partial Least Squares Structural Equation Modeling with R

    Science.gov (United States)

    Ravand, Hamdollah; Baghaei, Purya

    2016-01-01

    Structural equation modeling (SEM) has become widespread in educational and psychological research. Its flexibility in addressing complex theoretical models and the proper treatment of measurement error has made it the model of choice for many researchers in the social sciences. Nevertheless, the model imposes some daunting assumptions and…

  20. A data storage model for novel partial differential equation descretizations.

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, Wendy S.K.; Thompson, David C.; Pebay, Philippe Pierre

    2007-04-01

    The purpose of this report is to define a standard interface for storing and retrieving novel, non-traditional partial differential equation (PDE) discretizations. Although it focuses specifically on finite elements where state is associated with edges and faces of volumetric elements rather than nodes and the elements themselves (as implemented in ALEGRA), the proposed interface should be general enough to accommodate most discretizations, including hp-adaptive finite elements and even mimetic techniques that define fields over arbitrary polyhedra. This report reviews the representation of edge and face elements as implemented by ALEGRA. It then specifies a convention for storing these elements in EXODUS files by extending the EXODUS API to include edge and face blocks in addition to element blocks. Finally, it presents several techniques for rendering edge and face elements using VTK and ParaView, including the use of VTK's generic dataset interface for interpolating values interior to edges and faces.

  1. A note on the Dirichlet problem for model complex partial differential equations

    Science.gov (United States)

    Ashyralyev, Allaberen; Karaca, Bahriye

    2016-08-01

    Complex model partial differential equations of arbitrary order are considered. The uniqueness of the Dirichlet problem is studied. It is proved that the Dirichlet problem for higher order of complex partial differential equations with one complex variable has infinitely many solutions.

  2. Modeling of the wave transmission properties of large arteries using nonlinear elastic tubes.

    Science.gov (United States)

    Pythoud, F; Stergiopulos, N; Meister, J J

    1994-11-01

    We propose a new, simple way of constructing elastic tubes which can be used to model the nonlinear elastic properties of large arteries. The tube models are constructed from a silicon elastomer (Sylgard 184, Dow Corning), which exhibits a nonlinear behavior with increased stiffness at high strains. Tests conducted on different tube models showed that, with the proper choice of geometric parameters, the elastic properties, in terms of area-pressure relation and compliance, can be similar to that of real arteries.

  3. Artery buckling analysis using a two-layered wall model with collagen dispersion.

    Science.gov (United States)

    Mottahedi, Mohammad; Han, Hai-Chao

    2016-07-01

    Artery buckling has been proposed as a possible cause for artery tortuosity associated with various vascular diseases. Since microstructure of arterial wall changes with aging and diseases, it is essential to establish the relationship between microscopic wall structure and artery buckling behavior. The objective of this study was to developed arterial buckling equations to incorporate the two-layered wall structure with dispersed collagen fiber distribution. Seven porcine carotid arteries were tested for buckling to determine their critical buckling pressures at different axial stretch ratios. The mechanical properties of these intact arteries and their intima-media layer were determined via pressurized inflation test. Collagen alignment was measured from histological sections and modeled by a modified von-Mises distribution. Buckling equations were developed accordingly using microstructure-motivated strain energy function. Our results demonstrated that collagen fibers disperse around two mean orientations symmetrically to the circumferential direction (39.02°±3.04°) in the adventitia layer; while aligning closely in the circumferential direction (2.06°±3.88°) in the media layer. The microstructure based two-layered model with collagen fiber dispersion described the buckling behavior of arteries well with the model predicted critical pressures match well with the experimental measurement. Parametric studies showed that with increasing fiber dispersion parameter, the predicted critical buckling pressure increases. These results validate the microstructure-based model equations for artery buckling and set a base for further studies to predict the stability of arteries due to microstructural changes associated with vascular diseases and aging.

  4. A constituent-based model of age-related changes in conduit arteries.

    Science.gov (United States)

    Tsamis, Alkiviadis; Rachev, Alexander; Stergiopulos, Nikos

    2011-10-01

    In the present report, a constituent-based theoretical model of age-related changes in geometry and mechanical properties of conduit arteries is proposed. The model was based on the premise that given the time course of the load on an artery and the accumulation of advanced glycation end-products in the arterial tissue, the initial geometric dimensions and properties of the arterial tissue can be predicted by a solution of a boundary value problem for the governing equations that follow from finite elasticity, structure-based constitutive modeling within the constrained mixture theory, continuum damage theory, and global growth approach for stress-induced structure-based remodeling. An illustrative example of the age-related changes in geometry, structure, composition, and mechanical properties of a human thoracic aorta is considered. Model predictions were in good qualitative agreement with available experimental data in the literature. Limitations and perspectives for refining the model are discussed.

  5. Stochastic partial differential equations a modeling, white noise functional approach

    CERN Document Server

    Holden, Helge; Ubøe, Jan; Zhang, Tusheng

    1996-01-01

    This book is based on research that, to a large extent, started around 1990, when a research project on fluid flow in stochastic reservoirs was initiated by a group including some of us with the support of VISTA, a research coopera­ tion between the Norwegian Academy of Science and Letters and Den norske stats oljeselskap A.S. (Statoil). The purpose of the project was to use stochastic partial differential equations (SPDEs) to describe the flow of fluid in a medium where some of the parameters, e.g., the permeability, were stochastic or "noisy". We soon realized that the theory of SPDEs at the time was insufficient to handle such equations. Therefore it became our aim to develop a new mathematically rigorous theory that satisfied the following conditions. 1) The theory should be physically meaningful and realistic, and the corre­ sponding solutions should make sense physically and should be useful in applications. 2) The theory should be general enough to handle many of the interesting SPDEs that occur in r...

  6. Partially linear varying coefficient models stratified by a functional covariate

    KAUST Repository

    Maity, Arnab

    2012-10-01

    We consider the problem of estimation in semiparametric varying coefficient models where the covariate modifying the varying coefficients is functional and is modeled nonparametrically. We develop a kernel-based estimator of the nonparametric component and a profiling estimator of the parametric component of the model and derive their asymptotic properties. Specifically, we show the consistency of the nonparametric functional estimates and derive the asymptotic expansion of the estimates of the parametric component. We illustrate the performance of our methodology using a simulation study and a real data application.

  7. Mathematical analysis of partial differential equations modeling electrostatic MEMS

    CERN Document Server

    Esposito, Pierpaolo; Guo, Yujin

    2010-01-01

    Micro- and nanoelectromechanical systems (MEMS and NEMS), which combine electronics with miniature-size mechanical devices, are essential components of modern technology. It is the mathematical model describing "electrostatically actuated" MEMS that is addressed in this monograph. Even the simplified models that the authors deal with still lead to very interesting second- and fourth-order nonlinear elliptic equations (in the stationary case) and to nonlinear parabolic equations (in the dynamic case). While nonlinear eigenvalue problems-where the stationary MEMS models fit-are a well-developed

  8. Partially Linear Varying Coefficient Models Stratified by a Functional Covariate.

    Science.gov (United States)

    Maity, Arnab; Huang, Jianhua Z

    2012-10-01

    We consider the problem of estimation in semiparametric varying coefficient models where the covariate modifying the varying coefficients is functional and is modeled nonparametrically. We develop a kernel-based estimator of the nonparametric component and a profiling estimator of the parametric component of the model and derive their asymptotic properties. Specifically, we show the consistency of the nonparametric functional estimates and derive the asymptotic expansion of the estimates of the parametric component. We illustrate the performance of our methodology using a simulation study and a real data application.

  9. Remodeling and Estimation for Sparse Partially Linear Regression Models

    Directory of Open Access Journals (Sweden)

    Yunhui Zeng

    2013-01-01

    Full Text Available When the dimension of covariates in the regression model is high, one usually uses a submodel as a working model that contains significant variables. But it may be highly biased and the resulting estimator of the parameter of interest may be very poor when the coefficients of removed variables are not exactly zero. In this paper, based on the selected submodel, we introduce a two-stage remodeling method to get the consistent estimator for the parameter of interest. More precisely, in the first stage, by a multistep adjustment, we reconstruct an unbiased model based on the correlation information between the covariates; in the second stage, we further reduce the adjusted model by a semiparametric variable selection method and get a new estimator of the parameter of interest simultaneously. Its convergence rate and asymptotic normality are also obtained. The simulation results further illustrate that the new estimator outperforms those obtained by the submodel and the full model in the sense of mean square errors of point estimation and mean square prediction errors of model prediction.

  10. Partial Model of Insulator/Insulator Contact Charging

    Science.gov (United States)

    Hogue, Michael; Calle, C. I.; Buhler, C. R.; Mucciolo, E. R.

    2005-01-01

    Two papers present a two-phase equilibrium model that partly explains insulator/ insulator contact charging. In this model, a vapor of ions within a gas is in equilibrium with a submonolayer of ions of the same species that have been adsorbed on the surface of an insulator. The surface is modeled as having localized states, each with a certain energy of adsorption for an ion. In an earlier version of the model described in the first paper, the ions do not interact with each other. Using the grand canonical ensemble, the chemical potentials of both vapor and absorbed phases are derived and equated to determine the vapor pressure. If a charge is assigned to the vapor particles (in particular, if single ionization is assumed), then the surface charge density associated with adsorbed ions can be calculated as a function of pressure. In a later version of the model presented in the second paper, the submodel of the vapor phase is extended to include electrostatic interactions between vapor ions and adsorbed ones as well as the screening effect, at a given distance from the surface, of ions closer to the surface. Theoretical values of this model closely match preliminary experimental data on the discharge of insulators as a function of pressure.

  11. A unified lattice Boltzmann model for some nonlinear partial differential equations

    Energy Technology Data Exchange (ETDEWEB)

    Chai Zhenhua [State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, Wuhan 430074 (China); Shi Baochang [Department of Mathematics, Huazhong University of Science and Technology, Wuhan 430074 (China)], E-mail: sbchust@126.com; Zheng Lin [Department of Mathematics, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2008-05-15

    In this paper, a unified and novel lattice Boltzmann model is proposed for solving nonlinear partial differential equation that has the form DU{sub t} + {alpha}UU{sub x} + {beta}U{sup n}U{sub x} - {gamma}U{sub xx} + {delta} U{sub xxx} = F(x,t). Numerical results agree well with the analytical solutions and results derived by existing literature, which indicates the present model is satisfactory and efficient on solving nonlinear partial differential equations.

  12. A study of partial pressure of arterial carbon dioxide and end-tidal carbon dioxide correlation in intraoperative and postoperative period in neurosurgical patients

    Science.gov (United States)

    Gaur, Pallavi; Harde, Minal; Gujjar, Pinakin; Deosarkar, Devanand; Bhadade, Rakesh

    2017-01-01

    Background and Aim: Monitoring carbon dioxide (CO2) is of utmost importance in neurosurgical patients. It is measured by partial pressure of arterial CO2 (PaCO2) and end-tidal CO2 (ETCO2). We aimed to study the correlation between PaCO2 and ETCO2 in neurosurgical patients in the intraoperative and postoperative period on mechanical ventilation in Postanesthesia Care Unit (PACU). Methodology: This was prospective observational study done at tertiary care teaching public hospital over a period of 1 year. We studied 30 patients undergoing elective craniotomy intraoperatively and in the postoperative period on mechanical ventilation for 24 h. Serial measurement of ETCO2 and PaCO2 at baseline, hourly intraoperatively and every 6 hourly in the PACU were studied. Data analysis was done using SPSS software version 20. Results: The mean PaCO2–ETCO2 gradient intraoperatively over 4 h is 3.331 ± 2.856 and postoperatively over 24 h is 2.779 ± 2.932 and lies in 95% confidence interval. There was statistically significant correlation between PaCO2 and ETCO2 intraoperatively baseline, 1 h, 2 h, 3 h, and 4 h with Pearson's correlation coefficients of 0.799, 0.522, 0582, 0.439, and 0.547, respectively (P < 0.05). In PACU at baseline, 6 h, 12 h, 18 h, and 24 h Pearson's correlation coefficients were. 534, −0.032, 0.522, 0.242, 0.592, and 0.547, respectively, which are highly significant at three instances (P < 0.01). Conclusion: ETCO2 correlates PaCO2 with acceptable accuracy in neurosurgical patients in the intraoperative and postoperative period on mechanical ventilation in Intensive Care Unit. Thus, continuous and noninvasive ETCO2 can be used as a reliable guide to estimate arterial PCO2 during neurosurgical procedures and in PACU. PMID:28761526

  13. An alternative model of vascularized bone marrow transplant: partial femur transplantation.

    Science.gov (United States)

    Chen, Jian-Wu; Chen, Chen; Su, Ying-Jun; Yan, Lun; Wang, Shi-Ping; Guo, Shu-Zhong

    2014-12-01

    The vascularized whole femur transplantation model is one of the commonly used vascularized bone marrow transplant models. It involves technical complexity and morbidities. To optimize this model, we took 2/3 femur as the carrier of bone marrow cells, and developed a vascularized partial femur model. Four experimental groups were carried out, namely, the syngeneic partial femur transplantation, allogeneic partial femur transplantation with or without cyclosporine A, and allogeneic whole femur transplantation with cyclosporine A. The results showed that the partial femur model was technically simpler and shortened the operative and ischemia time compared to the whole femur model. Gross and histologic appearance confirmed the viability of femur, and its bone marrow inside the bone could also maintain normal morphologically at 60-day posttransplant. Besides, donor multilineage chimerism could be continuously detected in immunosuppressed allogeneic partial femur recipients at 1-, 2-, 3-, 4-, and 8-week posttransplant, and it showed no significant differences when compared with whole femur transplantation. Meanwhile, long-term engraftment of donor-origin cells was also confirmed in recipients' bone marrow, lymph nodes, and spleen, but not in thymus. Therefore, the vascularized partial femur can serve as a continuous resource of bone morrow cells and may provide a useful tool for the study of immune tolerance in vascularized composite allotransplantation.

  14. Partial median sternotomy as a minimal access for off-pump coronary artery bypass grafting: feasibility of the lower-end sternal splitting approach.

    Science.gov (United States)

    Niinami, H; Takeuchi, Y; Ichikawa, S; Suda, Y

    2001-09-01

    Off-pump coronary artery bypass grafting (OPCAB) can be performed in several ways using a minimally invasive approach (MIDCAB). Using the left anterior small thoracotomy (LAST) approach, only the LAD can be grafted. To expand the indications for MIDCAB from single-vessel disease to double-vessel disease, we have used a partial sternotomy without a transverse cut, namely, the lower-end sternal splitting (LESS) approach. Through this approach, the LAD and RCA can be revascularized by means of a single small incision without the risk of damaging the tissue around the intercostal space during harvesting of ITA when the sternum is transversely divided. The purpose of this study was to demonstrate the feasibility and safety of this technique. Between November 1999 and November 2000, a total of 22 patients underwent MIDCAB through a lower midline skin incision from the fourth intercostal space to the xiphoid process with longitudinal division of the lower half sternum up to the 3rd rib, without either a T- or reversed L-shaped division of the sternum. Of the patients, 14 had LAD disease only, 5 had both LAD and RCA disease, 2 had RCA disease only, and 1 had left main trunk disease. Two of the operations were of redo coronary artery bypass grafting. The mean age was 69.5 +/- 6.1 years (range 58 to 77 years). The mean length of the skin incision was 8.5 +/- 1.4 cm (range 7 to 12 cm). No hospital death or morbidity was observed. All patients had arterial conduits: LIMA in 20 patients, RIMA in 3, RGEA in 4, and RA in 1. The mean number of grafts per patient was 1.3 +/- 0.6 (range 1 to 3). No blood transfusion was required perioperatively. The patency rate was 96%. All patients were in New York Heart Association class I and no wound complications or postoperative pain occurred during follow-up. Our experience demonstrates that the LESS approach for MIDCAB is technically feasible for revascularizing not only the LAD but also the RCA system, with the same small incision using

  15. Using Partial Credit and Response History to Model User Knowledge

    Science.gov (United States)

    Van Inwegen, Eric G.; Adjei, Seth A.; Wang, Yan; Heffernan, Neil T.

    2015-01-01

    User modelling algorithms such as Performance Factors Analysis and Knowledge Tracing seek to determine a student's knowledge state by analyzing (among other features) right and wrong answers. Anyone who has ever graded an assignment by hand knows that some answers are "more wrong" than others; i.e. they display less of an understanding…

  16. Modelling transport of graded sediment under partial transport conditions

    NARCIS (Netherlands)

    Tuijnder, Arjan; Ribberink, Jan S.; Hulscher, Suzanne J.M.H.; Weerts, H.J.T.; Ritsema, I.L; van Os, A.G.

    2006-01-01

    Tentative plans are presented for research on the modelling of i) selective sediment transport in suspension and as bed-load, and ii) large-scale morphology in mixed sand-gravel bed rivers. Since the planning of the research is still in its early stages, the plans are flexible. Please feel free to

  17. Optical modeling of sunlight by using partially coherent sources in organic solar cells.

    Science.gov (United States)

    Alaibakhsh, Hamzeh; Darvish, Ghafar

    2016-03-01

    We investigate the effects of coherent and partially coherent sources in optical modeling of organic solar cells. Two different organic solar cells are investigated: one without substrate and the other with a millimeter-sized glass substrate. The coherent light absorption is calculated with rigorous coupled-wave analysis. The result of this method is convolved with a distribution function to calculate the partially coherent light absorption. We propose a new formulation to accurately model sunlight as a set of partially coherent sources. In the structure with glass substrate, the accurate sunlight modeling results in the elimination of coherent effects in the thick substrate, but the coherency in other layers is not affected. Using partially coherent sources instead of coherent sources for simulations with sunlight results in a smoother absorption spectrum, but the change in the absorption efficiency is negligible.

  18. Partial liquid ventilation decreases tissue and serum tumor necrosis factor-α concentrations in acute lung injury model of immature piglet induced by oleic acid

    Institute of Scientific and Technical Information of China (English)

    ZHU Yao-bin; FAN Xiang-ming; LI Xiao-feng; LI Zhi-qiang; WANG Qiang; SUN Li-zhong; LIU Ying-long

    2012-01-01

    Background Pediatric patients are susceptible to lung injury.Acute lung injury in children often results in high mortality.Partial liquid ventilation (PLV) has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models.This study was designed to examine the hypothesis that PLV would attenuate the production of local and systemic tumor necrosis factor (TNF)-α in an immature piglet model of acute lung injury induced by oleic acid (OA).Methods Twelve Chinese immature piglets were induced acute lung injury by OA.The animals were randomly assigned to two groups of six animals,(1) conventional mechanical ventilation (MV) group and (2) PLV with 10 ml/kg FC-77 group.Results Compared with MV group,the PLV group had better cardiopulmonary variables (P <0.05).These variables included heart rate,mean blood pressure,blood pH,partial pressure of arterial oxygen (PaO2),PaO2/inspired O2 fraction (FiO2) and partial pressure of arterial carbon dioxide (PaCO2).PLV reduced TNF-α levels both in plasma and tissue compared with MV group (P <0.05).Conclusion PLV provides protective effects against TNF-a response in OA-induced acute lung injury in immature piglets.

  19. Soft sensor modelling by time difference, recursive partial least squares and adaptive model updating

    Science.gov (United States)

    Fu, Y.; Yang, W.; Xu, O.; Zhou, L.; Wang, J.

    2017-04-01

    To investigate time-variant and nonlinear characteristics in industrial processes, a soft sensor modelling method based on time difference, moving-window recursive partial least square (PLS) and adaptive model updating is proposed. In this method, time difference values of input and output variables are used as training samples to construct the model, which can reduce the effects of the nonlinear characteristic on modelling accuracy and retain the advantages of recursive PLS algorithm. To solve the high updating frequency of the model, a confidence value is introduced, which can be updated adaptively according to the results of the model performance assessment. Once the confidence value is updated, the model can be updated. The proposed method has been used to predict the 4-carboxy-benz-aldehyde (CBA) content in the purified terephthalic acid (PTA) oxidation reaction process. The results show that the proposed soft sensor modelling method can reduce computation effectively, improve prediction accuracy by making use of process information and reflect the process characteristics accurately.

  20. A model for geometric and mechanical adaptation of arteries to sustained hypertension.

    Science.gov (United States)

    Rachev, A; Stergiopulos, N; Meister, J J

    1998-02-01

    This study aimed to model phenomenologically the dynamics of arterial wall remodeling under hypertensive conditions. Sustained hypertension was simulated by a step increase in blood pressure. The arterial wall was considered to be a thick-walled tube made of nonlinear elastic incompressible material. Remodeling rate equations were postulated for the evolution of the geometric dimensions of the hypertensive artery at the zero-stress state, as well as for one of the material constants in the constitutive equations. The driving stimuli for the geometric adaptation are the normalized deviations of wall stresses from their values under normotensive conditions. The geometric dimensions are modulated by the evolution of the deformed inner radius, which serves to restore the level of the flow-induced shear stresses at the arterial endothelium. Mechanical adaptation is driven by the difference between the area compliance under hypertensive and normotensive conditions. The predicted time course of the geometry and mechanical properties of arterial wall are in good qualitative agreement with published experimental findings. The model predicts that the geometric adaptation maintains the stress distribution in arterial wall to its control level, while the mechanical adaptation restores the normal arterial function under induced hypertension.

  1. ROBUST ESTIMATION IN PARTIAL LINEAR MIXED MODEL FOR LONGITUDINAL DATA

    Institute of Scientific and Technical Information of China (English)

    Qin Guoyou; Zhu Zhongyi

    2008-01-01

    In this article, robust generalized estimating equation for the analysis of par- tial linear mixed model for longitudinal data is used. The authors approximate the non- parametric function by a regression spline. Under some regular conditions, the asymptotic properties of the estimators are obtained. To avoid the computation of high-dimensional integral, a robust Monte Carlo Newton-Raphson algorithm is used. Some simulations are carried out to study the performance of the proposed robust estimators. In addition, the authors also study the robustness and the efficiency of the proposed estimators by simulation. Finally, two real longitudinal data sets are analyzed.

  2. Injection-moulded models of major and minor arteries: the variability of model wall thickness owing to casting technique.

    Science.gov (United States)

    O'Brien, T; Morris, L; O'Donnell, M; Walsh, M; McGloughlin, T

    2005-09-01

    Cardiovascular disease of major and minor arteries is a common cause of death in Western society. The wall mechanics and haemodynamics within the arteries are considered to be important factors in the disease formation process. This paper is concerned with the development of an efficient computer-integrated technique to manufacture idealized and realistic models of diseased major and minor arteries from radiological images and to address the issue of model wall thickness variability. Variations in wall thickness from the original computer models to the final castings are quantified using a CCD camera. The results found that wall thickness variation from the major and minor idealized artery models to design specification were insignificant, up to a maximum of 16 per cent. In realistic models, however, differences were up to 23 per cent in the major arterial models and 58 per cent in the minor arterial models, but the wall thickness variability remained within the limits of previously reported wall thickness results. It is concluded that the described injection moulding procedure yields idealized and realistic castings suitable for use in experimental investigations, with idealized models giving better agreement with design. Wall thickness is variable and should be assessed after the models are manufactured.

  3. Calculus for cognitive scientists partial differential equation models

    CERN Document Server

    Peterson, James K

    2016-01-01

    This book shows cognitive scientists in training how mathematics, computer science and science can be usefully and seamlessly intertwined. It is a follow-up to the first two volumes on mathematics for cognitive scientists, and includes the mathematics and computational tools needed to understand how to compute the terms in the Fourier series expansions that solve the cable equation. The latter is derived from first principles by going back to cellular biology and the relevant biophysics.  A detailed discussion of ion movement through cellular membranes, and an explanation of how the equations that govern such ion movement leading to the standard transient cable equation are included. There are also solutions for the cable model using separation of variables, as well an explanation of why Fourier series converge and a description of the implementation of MatLab tools to compute the solutions. Finally, the standard Hodgkin - Huxley model is developed for an excitable neuron and is solved using MatLab.

  4. New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model

    DEFF Research Database (Denmark)

    Enevoldsen, Marie Sand; Henneberg, Kaj-Åge; Jensen, Jørgen Arendt

    2011-01-01

    Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases; it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data...... caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models...

  5. New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model

    DEFF Research Database (Denmark)

    Enevoldsen, Majken; Henneberg, K-A; Jensen, J A

    2011-01-01

    Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases; it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data...... by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture...

  6. Malignant infarction of the middle cerebral artery in a porcine model. A pilot study

    Science.gov (United States)

    Martínez-Valverde, Tamara; Sánchez-Guerrero, Ángela; Campos, Mireia; Esteves, Marielle; Gandara, Dario; Torné, Ramon; Castro, Lidia; Dalmau, Antoni; Tibau, Joan

    2017-01-01

    Background and purpose Interspecies variability and poor clinical translation from rodent studies indicate that large gyrencephalic animal stroke models are urgently needed. We present a proof-of-principle study describing an alternative animal model of malignant infarction of the middle cerebral artery (MCA) in the common pig and illustrate some of its potential applications. We report on metabolic patterns, ionic profile, brain partial pressure of oxygen (PtiO2), expression of sulfonylurea receptor 1 (SUR1), and the transient receptor potential melastatin 4 (TRPM4). Methods A 5-hour ischemic infarct of the MCA territory was performed in 5 2.5-to-3-month-old female hybrid pigs (Large White x Landrace) using a frontotemporal approach. The core and penumbra areas were intraoperatively monitored to determine the metabolic and ionic profiles. To determine the infarct volume, 2,3,5-triphenyltetrazolium chloride staining and immunohistochemistry analysis was performed to determine SUR1 and TRPM4 expression. Results PtiO2 monitoring showed an abrupt reduction in values close to 0 mmHg after MCA occlusion in the core area. Hourly cerebral microdialysis showed that the infarcted tissue was characterized by reduced concentrations of glucose (0.03 mM) and pyruvate (0.003 mM) and increases in lactate levels (8.87mM), lactate-pyruvate ratio (4202), glycerol levels (588 μM), and potassium concentration (27.9 mmol/L). Immunohistochemical analysis showed increased expression of SUR1-TRPM4 channels. Conclusions The aim of the present proof-of-principle study was to document the feasibility of a large animal model of malignant MCA infarction by performing transcranial occlusion of the MCA in the common pig, as an alternative to lisencephalic animals. This model may be useful for detailed studies of cerebral ischemia mechanisms and the development of neuroprotective strategies. PMID:28235044

  7. Predicting chaotic time series with a partial model.

    Science.gov (United States)

    Hamilton, Franz; Berry, Tyrus; Sauer, Timothy

    2015-07-01

    Methods for forecasting time series are a critical aspect of the understanding and control of complex networks. When the model of the network is unknown, nonparametric methods for prediction have been developed, based on concepts of attractor reconstruction pioneered by Takens and others. In this Rapid Communication we consider how to make use of a subset of the system equations, if they are known, to improve the predictive capability of forecasting methods. A counterintuitive implication of the results is that knowledge of the evolution equation of even one variable, if known, can improve forecasting of all variables. The method is illustrated on data from the Lorenz attractor and from a small network with chaotic dynamics.

  8. Partial Differential Equations of an Epidemic Model with Spatial Diffusion

    Directory of Open Access Journals (Sweden)

    El Mehdi Lotfi

    2014-01-01

    Full Text Available The aim of this paper is to study the dynamics of a reaction-diffusion SIR epidemic model with specific nonlinear incidence rate. The global existence, positivity, and boundedness of solutions for a reaction-diffusion system with homogeneous Neumann boundary conditions are proved. The local stability of the disease-free equilibrium and endemic equilibrium is obtained via characteristic equations. By means of Lyapunov functional, the global stability of both equilibria is investigated. More precisely, our results show that the disease-free equilibrium is globally asymptotically stable if the basic reproduction number is less than or equal to unity, which leads to the eradication of disease from population. When the basic reproduction number is greater than unity, then disease-free equilibrium becomes unstable and the endemic equilibrium is globally asymptotically stable; in this case the disease persists in the population. Numerical simulations are presented to illustrate our theoretical results.

  9. Anomaly Mediation and Fixed Point in Partially N = 2 Supersymmetric Standard Models

    CERN Document Server

    Yin, Wen

    2016-01-01

    To explain the tension between the observed Higgs boson mass and the experimental deviations from the Standard Model (SM) prediction in flavor physics, especially the experimental anomaly of the muon anomalous dipole moment (muon $g-2$), we study partially $N=2$ supersymmetric (SUSY) extensions of the SM (partially $N=2$ SSMs). In this kind of model, an $N=2$ SUSY sector is sequestered from the SUSY breaking due to $SO(2)_R$ symmetry at the tree-level. We show that the low energy physics in the $N=2$ sector is controlled by a fixed point and hence approximately UV insensitive. Moreover at this fixed point, the tachyonic slepton problem of anomaly mediation is always solved. In a concrete partially $N=2$ SSM, the muon $g-2$ anomaly is explained within the $1\\sigma$ level error with $mathcal{O}(100)$TEV cosmologically favored gravitino. We also propose some new dark matter candidates as a natural consequence of partially $N=2$ SSMs.

  10. A higher order lattice BGK model for simulating some nonlinear partial differential equations

    Institute of Scientific and Technical Information of China (English)

    LAI HuiLin; MA ChangFeng

    2009-01-01

    In this paper, we consider a one-dimensional nonlinear partial differential equation that has the form ut + αuux+βunux-γuxx+δuxxx= F(U). A higher order lattice Bhatnager-Gross-Krook (BGK) model with an amending-function is proposed. With the Chapman-Enskog expansion, different kinds of nonlinear partial differential equations are recovered correctly from the continuous Boltzmann equation. The numerical results show that this method is very effective.

  11. A higher order lattice BGK model for simulating some nonlinear partial differential equations

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In this paper, we consider a one-dimensional nonlinear partial differential equation that has the form ut + αuux + βunux - γuxx + δuxxx = F(u). A higher order lattice Bhatnager-Gross-Krook (BGK) model with an amending-function is proposed. With the Chapman-Enskog expansion, different kinds of nonlinear partial differential equations are recovered correctly from the continuous Boltzmann equation. The numerical results show that this method is very effective.

  12. General approach for modeling partial coherence in spectroscopic Mueller matrix polarimetry.

    Science.gov (United States)

    Hingerl, Kurt; Ossikovski, Razvigor

    2016-01-15

    We present a general formalism for modeling partial coherence in spectroscopic Mueller matrix measurements of stratified media. The approach is based on the statistical definition of a Mueller matrix, as well as, on the fundamental representation of the measurement process as the convolution of the sample response with a specific instrumental function. The formalism is readily extended to describe other measurement imperfections occurring jointly with partial coherence and resulting in depolarizing experimental Mueller matrices.

  13. AN ANALYSIS MODEL OF PULSATILE BLOOD FLOW IN ARTERIES

    Institute of Scientific and Technical Information of China (English)

    LIUZhao-rong; XUGang; CHENYong; TENGZhong0=zhao; QINKai-rong

    2003-01-01

    Blood flow in artery was treated as the flow under equilibriums state(the steady flow under mean pressure)combined with the periodically small pulsatile flow.Using vascular strain energy function advanced by Fung,the vascular stress-strain relationship under equilibrium state was analyzed and the circumferential and axial elastic moduli were deduced that are expressed while the arterial strains around the equilibrium state are relatively small,so that the equations of vesse wall motion under the pulsatile pressure could be established here.Through solving both the vessel equations and the linear Navier-Stokes equations,the analytic expressions of the blood flow velocities and the vascular displacements were obtained.The influence of the difference between vascular circumferentia and axial elasticities on pulsatile blood flow and vascular motion was discussed in details.

  14. AN ANALYSIS MODEL OF PULSATILE BLOOD FLOW IN ARTERIES

    Institute of Scientific and Technical Information of China (English)

    柳兆荣; 徐刚; 陈泳; 滕忠照; 覃开蓉

    2003-01-01

    Blood flow in artery was treated as the flow under equilibrium state ( the steady flow under mean pressure ) combined with the periodically small pulsatile flow. Using vascular strain energy function advanced by Fung, the vascular stress-strain relationship under equilibrium state was analyzed and the circumferential and axial elastic moduli were deduced that are expressed while the arterial strains around the equilibrium state are relatively small, so that the equations of vessel wall motion under the pulsatile pressure could be established here. Through solving both the vessel equations and the linear NavierStokes equations, the analytic expressions of the blood flow velocities and the vascular displacements were obtained. The influence of the difference between vascular circumferential and axial elasticities on pulsatile blood flow and vascular motion was discussed in details.

  15. The prevention and treatment of complications in partial spleen artery embolotherapy%部分脾动脉栓塞术并发症预防及处理

    Institute of Scientific and Technical Information of China (English)

    祝青; 蒲洪波

    2014-01-01

    Objective to explore the effect of splenic artery embolization for the hypersplenism and the countermeasures for its complications. Methods the data of 29 patients treated with splenic artery embolization between January 2012 and July 2014 were retrospectively analyzed, including hemogram change, treatment or prevention of postoperative complications.Results the number of postoperative platelets and white blood cells in 29 patients were rising better than that before operation (P<0.05), with statistical significance and the number of red blood cells showed no obvious change. All of the 29 cases occurred postoperative embolism syndrome with different degree, 4 cases with a small amount of pleural effusion in the left side, 1 case with massive pleural effusion, 1 case with splenic abscess, 2 cases with intractable hiccups, 5 cases with postoperative persisting fever, 1 case with the puncture point hematoma and 1 case with lower extremity deep vein thrombosis on the left side. no complications of spleen rupture and pancreatitis occured. Conclusion after partial splenic artery embolization, peripheral blood white cells and platelets elevated more obviously than that before operation. though postoperative complications may occurred, they can be restored. splenic artery embolization is an effective method for treatment of the hypersplenism, worthy of clinical promotion.%目的:探讨脾动脉栓塞术对脾功能亢进的疗效及并发症的处理措施。方法回顾分析2012年3月至2014年7月间29例行脾动脉栓塞术患者的血象变化情况及术后并发症的预防、发生及处理措施。结果29例患者,栓塞术后血小板、白细胞均有较明显回升,与术前比较P <0.05,有统计学意义,红细胞未见明显变化。29例术后均发生不同程度的栓塞后综合征,左侧少量胸水4例、大量胸水1例,脾脓肿1例,顽固性呃逆2例,术后持续发热5例,穿刺点血肿1例,左侧下肢深静脉血栓1

  16. Evaluation of Arterial Impairment after Experimental Gelatin Sponge Embolization in a Rabbit Renal Model

    OpenAIRE

    Oh, Jung Suk; Lee, Hae Giu; Chun, Ho Jong; Choi, Byung Gil; Choi, Yeong Jin

    2015-01-01

    Objective Arterial stenosis is a major obstacle for subsequent interventional procedures. We hypothesized that the stenosis is caused by gelatin sponge embolization and performed an experimental study in a rabbit renal model. Materials and Methods A total of 24 rabbits were embolized with porcine gelatin sponge particles injected into the renal arteries. Four rabbits were sacrificed on 1 day, 4 days, 1 week, 2 weeks, 3 weeks, and 4 weeks after embolization. Microscopic evaluations were perfor...

  17. Multi-loop adaptive internal model control based on a dynamic partial least squares model

    Institute of Scientific and Technical Information of China (English)

    Zhao ZHAO; Bin HU; Jun LIANG

    2011-01-01

    A multi-loop adaptive internal model control (IMC) strategy based on a dynamic partial least squares (PLS) framework is proposed to account for plant model errors caused by slow aging, drift in operational conditions, or environmental changes. Since PLS decomposition structure enables multi-loop controller design within latent spaces, a multivariable adaptive control scheme can be converted easily into several independent univariable control loops in the PLS space. In each latent subspace,once the model error exceeds a specific threshold, online adaptation rules are implemented separately to correct the plant model mismatch via a recursive least squares (RLS) algorithm. Because the IMC extracts the inverse of the minimum part of the internal model as its structure, the IMC controller is self-tuned by explicitly updating the parameters, which are parts of the internal model.Both parameter convergence and system stability are briefly analyzed, and proved to be effective. Finally, the proposed control scheme is tested and evaluated using a widely-used benchmark of a multi-input multi-output (MIMO) system with pure delay.

  18. The Component Slope Linear Model for Calculating Intensive Partial Molar Properties: Application to Waste Glasses

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, Jacob G. [Washington River Protection Solutions, Richland, WA (United States)

    2013-01-11

    Partial molar properties are the changes occurring when the fraction of one component is varied while the fractions of all other component mole fractions change proportionally. They have many practical and theoretical applications in chemical thermodynamics. Partial molar properties of chemical mixtures are difficult to measure because the component mole fractions must sum to one, so a change in fraction of one component must be offset with a change in one or more other components. Given that more than one component fraction is changing at a time, it is difficult to assign a change in measured response to a change in a single component. In this study, the Component Slope Linear Model (CSLM), a model previously published in the statistics literature, is shown to have coefficients that correspond to the intensive partial molar properties. If a measured property is plotted against the mole fraction of a component while keeping the proportions of all other components constant, the slope at any given point on a graph of this curve is the partial molar property for that constituent. Actually plotting this graph has been used to determine partial molar properties for many years. The CSLM directly includes this slope in a model that predicts properties as a function of the component mole fractions. This model is demonstrated by applying it to the constant pressure heat capacity data from the NaOH-NaAl(OH{sub 4}H{sub 2}O system, a system that simplifies Hanford nuclear waste. The partial molar properties of H{sub 2}O, NaOH, and NaAl(OH){sub 4} are determined. The equivalence of the CSLM and the graphical method is verified by comparing results detennined by the two methods. The CSLM model has been previously used to predict the liquidus temperature of spinel crystals precipitated from Hanford waste glass. Those model coefficients are re-interpreted here as the partial molar spinel liquidus temperature of the glass components.

  19. Efficient Estimation for Semiparametric Varying Coefficient Partially Linear Regression Models with Current Status Data

    Institute of Scientific and Technical Information of China (English)

    Tao Hu; Heng-jian Cui; Xing-wei Tong

    2009-01-01

    This article considers a semiparametric varying-coefficient partially linear regression model with current status data. The semiparametric varying-coefficient partially linear regression model which is a gen-eralization of the partially linear regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. A Sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. Under some mild conditions, the estimators are shown to be strongly consistent. The convergence rate of the estima-tor for the unknown smooth function is obtained and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. Simulation studies are conducted to examine the small-sample properties of the proposed estimates and a real dataset is used to illustrate our approach.

  20. Intra-arterial adenoviral mediated tumor transfection in a novel model of cancer gene therapy

    Directory of Open Access Journals (Sweden)

    Siemionow Maria

    2006-08-01

    Full Text Available Abstract Background The aim of the present study was to develop and characterize a novel in vivo cancer gene therapy model in which intra-arterial adenoviral gene delivery can be characterized. In this model, the rat cremaster muscle serves as the site for tumor growth and provides convenient and isolated access to the tumor parenchyma with discrete control of arterial and venous access for delivery of agents. Results Utilizing adenovirus encoding the green fluorescent protein we demonstrated broad tumor transfection. We also observed a dose dependant increment in luciferase activity at the tumor site using an adenovirus encoding the luciferase reporter gene. Finally, we tested the intra-arterial adenovirus dwelling time required to achieve optimal tumor transfection and observed a minimum time of 30 minutes. Conclusion We conclude that adenovirus mediated tumor transfection grown in the cremaster muscle of athymic nude rats via an intra-arterial route could be achieved. This model allows definition of the variables that affect intra-arterial tumor transfection. This particular study suggests that allowing a defined intra-tumor dwelling time by controlling the blood flow of the affected organ during vector infusion can optimize intra-arterial adenoviral delivery.

  1. A chiral quark model for meson electro-production in the S11 partial wave

    CERN Document Server

    Golli, Bojan

    2011-01-01

    We calculate the meson scattering and electroproduction amplitudes in the S11 partial wave in a coupled-channel approach that incorporates quasi-bound quark-model states. Using the quark wave functions and the quark-meson interaction from the Cloudy Bag Model, we obtain consistent predictions for the partial widths of the N(1535) and the N(1650) resonances as well as for the pion, eta and kaon electroproduction amplitudes. Our model suggests that the N(1535) resonance is dominantly a genuine three-quark state rather than a quasi-bound state of mesons and baryons.

  2. Fluid model for a partially packed dielectric barrier discharge plasma reactor

    Science.gov (United States)

    Gadkari, Siddharth; Tu, Xin; Gu, Sai

    2017-09-01

    In this work, a two-dimensional numerical fluid model is developed for a partially packed dielectric barrier discharge (DBD) in pure helium. Influence of packing on the discharge characteristics is studied by comparing the results of DBD with partial packing with those obtained for DBD with no packing. In the axial partial packing configuration studied in this work, the electric field strength was shown to be enhanced at the top surface of the spherical packing material and at the contact points between the packing and the dielectric layer. For each value of applied potential, DBD with partial packing showed an increase in the number of pulses in the current profile in the positive half cycle of the applied voltage, as compared to DBD with no packing. Addition of partial packing to the plasma-alone DBD also led to an increase in the electron and ion number densities at the moment of breakdown. The time averaged electron energy profiles showed that a much higher range of electron energy can be achieved with the use of partial packing as compared to no packing in a DBD, at the same applied power. The spatially and time averaged values over one voltage cycle also showed an increase in power density and electron energy on inclusion of partial packing in the DBD. For the applied voltage parameters studied in this work, the discharge was found to be consistently homogeneous and showed the characteristics of atmospheric pressure glow discharge.

  3. Clinical course of a partially thrombosed, symptomatic aneurysm of the basilar artery tip with partial recanalization subsequent to coiling; Verlaufsbeschreibung eines teilthrombosierten symptomatischen Basilariskopfaneurysmas mit teilweiser Rekanalisierung nach Coiling

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, V. [Universitaet des Saarlandes, Abteilung fuer Neuroradiologie, Homburg (Germany); Klinikum Saarbruecken, Institut fuer bildgebende Diagnostik und Interventionen, Saarbruecken (Germany); Axmann, C.; Reith, W. [Universitaet des Saarlandes, Abteilung fuer Neuroradiologie, Homburg (Germany)

    2006-05-15

    A 72-year-old patient was referred to the neuroradiological department for diagnostic angiography. She was suffering from vertigo and double vision. Magnetic resonance imaging performed elsewhere had demonstrated a giant aneurysm of the basilar artery tip 2 cm in diameter. Angiography revealed a large aneurysm with a broad neck that was partially thrombosed, which precluded closure by coiling. Neurosurgical management by clipping also appeared to be unsuitable because of the proximity to the cerebrum. The decision was reached to proceed expectantly by closely monitoring the clinical course. When the aneurysm increased in size in the ensuing weeks, coiling was performed successfully. Angiographic follow-up showed reperfusion of the aneurysm neck and closure was again achieved by repeat coiling. Reperfusion is not a rare complication following coiling and often necessitates renewed intervention. (orig.) [German] Eine 72-jaehrige Patientin wurde in der neuroradiologischen Abteilung zur diagnostischen Angiographie vorgestellt. Sie litt unter Schwindel und Doppelbildern. Eine auswaertige MR-Untersuchung des Gehirns zeigte ein Riesenaneurysma des Basilariskopfes mit einem Durchmesser von 2 cm. Die Angiographie zeigte ein grosses Aneurysma mit breitem Hals, das teilweise thrombosiert war. Dies liess einen Verschluss durch Coiling nicht zu. Eine neurochirurgische Behandlung durch Klippung erschien wegen der Naehe zum Mittelhirn ebenfalls ungeeignet. Man einigte sich auf ein abwartendes Vorgehen durch eine engmaschige Verlaufsbeobachtung. Als das Aneurysma in den folgenden Wochen eine Groessenzunahme zeigte, wurde erfolgreich ein Coiling durchgefuehrt. Eine angiographische Verlaufskontrolle zeigte eine Reperfusion des Aneurysmahalses. Erneut konnte ein Verschluss durch Coiling erzielt werden. Eine Reperfusion ist keine seltene Komplikation nach Coiling, die oft eine erneute Intervention erfordert. (orig.)

  4. A hemodynamics model to study the collective behavior of the ventricular-arterial system

    Science.gov (United States)

    Lin Wang, Yuh-Ying; Wang, Wei-Kung

    2013-01-01

    Applying principles from complex systems to study the efficacy of integrative therapies has become a new interest in medical research. We aimed to construct a concise model for the ventricular-arterial (VA) system and to provide a systematic method for exploring its overall behavior. The transportation of blood from the heart to the peripheral arterioles via hydraulic pressure forces was described by a multi-rank model. Parts of the VA system that have strong mutual interactions were combined into a single sub system. Sub systems of four different ranks were characterized. We then applied the multi-rank model to analyze the aortic pressure wave generated by the periodic ventricular blood ejection, the renal pressure in response to the input from the VA system, and the blood flowing from the renal artery to its arterioles. Maintaining the pressure distribution along the main arteries and in all of the organs with the lowest possible ventricular input turned out to be the first principle for the operation of an efficient VA system. By this principle, we pointed out the benefit of some arterial structures in mammals, derived specific regulation rules and deduced some fundamental concepts for healing. The justification of the biomechanics in our model that differed greatly from those in the prevailing models was given. We concluded that the oscillatory motion and the pressure pulse of the arterial system can be analyzed as steady states with resonance behaviors and suggested utilizing this model to construct integrative therapies for diseases correlated with abnormality in blood circulation.

  5. MODEL PENSKORAN PARTIAL CREDIT PADA BUTIR MULTIPLE TRUE-FALSE BIDANG FISIKA

    Directory of Open Access Journals (Sweden)

    Wasis Wasis

    2013-01-01

    Full Text Available Tujuan penelitian ini menghasilkan model penskoran politomus untuk respons butir multiple true-false, sehingga dapat mengestimasi secara lebih akurat kemampuan di bidang fisika. Pengembangan penskoran menggunakan Four-D model dan diuji akurasinya melalui penelitian empiris dan simulasi. Penelitian empiris menggunakan 15 butir multiple true-false yang diambil dari soal UMPTN tahun 1996-2006 dan dikenakan pada 410 mahasiswa baru FMIPA Universitas Negeri Surabaya angkatan tahun 2007. Respons peserta tes diskor dengan tiga model partial credit (PCM I; II; dan III dan secara dikotomus. Hasil penskoran dianalisis dengan program Quest untuk mendapat-kan estimasi tingkat kesukaran butir (δ dan estimasi ke-mampuan peserta (θ untuk menentukan nilai fungsi informasi tes dan kesalahan baku estimasi. Penelitian simulasi mengguna-kan data bangkitan berdasarkan parameter empiris (δ dan θ memakai program statistik SAS dan akurasi estimasinya di-analisis dengan metode root mean squared error (RMSE. Hasil penelitian ini menunjukkan: (i Penskoran PCM dengan pem-bobotan mampu mengestimasi kemampuan lebih akurat di-bandingkan tanpa pembobotan maupun secara dikotomus; (ii Semakin banyak jumlah kategori dalam penskoran partial credit, semakin akurat. Kata kunci: model penskoran partial credit, butir multiple true-false ____________________________________________________________ THE PARTIAL CREDIT SCORING MODEL FOR THE MULTIPLE TRUE-FALSE BUTIRS IN PHYSICS Abstract This study is an attempt to overcome the weaknesses. This study aims to produce a polytomous scoring model for responses to multiple true-false butirs in order to get a more accurate estimation of abilities in physics. It adopts the Four-D model and its accuracy is assessed through empirical and simulation studies. The empirical study employed 15 multiple true-false butirs taken from the New Students Entrance Test of State University the year of 1996–2006. It administered to 410 new students enrolled

  6. Development of a model of the coronary arterial tree for the 4D XCAT phantom

    Science.gov (United States)

    Fung, George S. K.; Segars, W. Paul; Gullberg, Grant T.; Tsui, Benjamin M. W.

    2011-09-01

    A detailed three-dimensional (3D) model of the coronary artery tree with cardiac motion has great potential for applications in a wide variety of medical imaging research areas. In this work, we first developed a computer-generated 3D model of the coronary arterial tree for the heart in the extended cardiac-torso (XCAT) phantom, thereby creating a realistic computer model of the human anatomy. The coronary arterial tree model was based on two datasets: (1) a gated cardiac dual-source computed tomography (CT) angiographic dataset obtained from a normal human subject and (2) statistical morphometric data of porcine hearts. The initial proximal segments of the vasculature and the anatomical details of the boundaries of the ventricles were defined by segmenting the CT data. An iterative rule-based generation method was developed and applied to extend the coronary arterial tree beyond the initial proximal segments. The algorithm was governed by three factors: (1) statistical morphometric measurements of the connectivity, lengths and diameters of the arterial segments; (2) avoidance forces from other vessel segments and the boundaries of the myocardium, and (3) optimality principles which minimize the drag force at the bifurcations of the generated tree. Using this algorithm, the 3D computational model of the largest six orders of the coronary arterial tree was generated, which spread across the myocardium of the left and right ventricles. The 3D coronary arterial tree model was then extended to 4D to simulate different cardiac phases by deforming the original 3D model according to the motion vector map of the 4D cardiac model of the XCAT phantom at the corresponding phases. As a result, a detailed and realistic 4D model of the coronary arterial tree was developed for the XCAT phantom by imposing constraints of anatomical and physiological characteristics of the coronary vasculature. This new 4D coronary artery tree model provides a unique simulation tool that can be

  7. Using AMMI, factorial regression and partial least squares regression models for interpreting genotype x environment interaction.

    NARCIS (Netherlands)

    Vargas, M.; Crossa, J.; Eeuwijk, van F.A.; Ramirez, M.E.; Sayre, K.

    1999-01-01

    Partial least squares (PLS) and factorial regression (FR) are statistical models that incorporate external environmental and/or cultivar variables for studying and interpreting genotype × environment interaction (GEl). The Additive Main effect and Multiplicative Interaction (AMMI) model uses only th

  8. Partially Testing a Process Model for Understanding Victim Responses to an Anticipated Worksite Closure

    Science.gov (United States)

    Blau, Gary

    2007-01-01

    This study partially tested a recent process model for understanding victim responses to worksite/function closure (W/FC) proposed by Blau [Blau, G. (2006). A process model for understanding victim responses to worksite/function closure. "Human Resource Management Review," 16, 12-28], in a pharmaceutical manufacturing site. Central to the model…

  9. The effect of ACE inhibition on the pulmonary vasculature in combined model of chronic hypoxia and pulmonary arterial banding in Sprague Dawley rats

    Science.gov (United States)

    Clarke, Shanelle; Baumgardt, Shelley; Molthen, Robert

    2010-03-01

    Microfocal CT was used to image the pulmonary arterial (PA) tree in rodent models of pulmonary hypertension (PH). CT images were used to measure the arterial tree diameter along the main arterial trunk at several hydrostatic intravascular pressures and calculate distensibility. High-resolution planar angiographic imaging was also used to examine distal PA microstructure. Data on pulmonary artery tree morphology improves our understanding of vascular remodeling and response to treatments. Angiotensin II (ATII) has been identified as a mediator of vasoconstriction and proliferative mitotic function. ATII has been shown to promote vascular smooth muscle cell hypertrophy and hyperplasia as well as stimulate synthesis of extracellular matrix proteins. Available ATII is targeted through angiotensin converting enzyme inhibitors (ACEIs), a method that has been used in animal models of PH to attenuate vascular remodeling and decrease pulmonary vascular resistance. In this study, we used rat models of chronic hypoxia to induce PH combined with partial left pulmonary artery occlusion (arterial banding, PLPAO) to evaluate effects of the ACEI, captopril, on pulmonary vascular hemodynamic and morphology. Male Sprague Dawley rats were placed in hypoxia (FiO2 0.1), with one group having underwent PLPAO three days prior to the chronic hypoxia. After the twenty-first day of hypoxia exposure, treatment was started with captopril (20 mg/kg/day) for an additional twenty-one days. At the endpoint, lungs were excised and isolated to examine: pulmonary vascular resistance, ACE activity, pulmonary vessel morphology and biomechanics. Hematocrit and RV/LV+septum ratio was also measured. CT planar images showed less vessel dropout in rats treated with captopril versus the non-treatment lungs. Distensibility data shows no change in rats treated with captopril in both chronic hypoxia (CH) and CH with PLPAO (CH+PLPAO) models. Hemodynamic measurements also show no change in the pulmonary vascular

  10. The Ratio of Partial Pressure Arterial Oxygen and Fraction of Inspired Oxygen 1 Day After Acute Respiratory Distress Syndrome Onset Can Predict the Outcomes of Involving Patients.

    Science.gov (United States)

    Lai, Chih-Cheng; Sung, Mei-I; Liu, Hsiao-Hua; Chen, Chin-Ming; Chiang, Shyh-Ren; Liu, Wei-Lun; Chao, Chien-Ming; Ho, Chung-Han; Weng, Shih-Feng; Hsing, Shu-Chen; Cheng, Kuo-Chen

    2016-04-01

    The initial hypoxemic level of acute respiratory distress syndrome (ARDS) defined according to Berlin definition might not be the optimal predictor for prognosis. We aimed to determine the predictive validity of the stabilized ratio of partial pressure arterial oxygen and fraction of inspired oxygen (PaO2/FiO2 ratio) following standard ventilator setting in the prognosis of patients with ARDS.This prospective observational study was conducted in a single tertiary medical center in Taiwan and compared the stabilized PaO2/FiO2 ratio (Day 1) following standard ventilator settings and the PaO2/FiO2 ratio on the day patients met ARDS Berlin criteria (Day 0). Patients admitted to intensive care units and in accordance with the Berlin criteria for ARDS were collected between December 1, 2012 and May 31, 2015. Main outcome was 28-day mortality. Arterial blood gas and ventilator setting on Days 0 and 1 were obtained.A total of 238 patients met the Berlin criteria for ARDS were enrolled, and they were classified as mild (n = 50), moderate (n = 125), and severe (n = 63) ARDS, respectively. Twelve (5%) patients who originally were classified as ARDS did not continually meet the Berlin definition, and a total of 134 (56%) patients had the changes regarding the severity of ARDS from Day 0 to Day 1. The 28-day mortality rate was 49.1%, and multivariate analysis identified age, PaO2/FiO2 on Day 1, number of organ failures, and positive fluid balance within 5 days as significant risk factors of death. Moreover, the area under receiver-operating curve for mortality prediction using PaO2/FiO2 on Day 1 was significant higher than that on Day 0 (P = 0.016).PaO2/FiO2 ratio on Day 1 after applying mechanical ventilator is a better predictor of outcomes in patients with ARDS than those on Day 0.

  11. Comparing model-based and model-free analysis methods for QUASAR arterial spin labeling perfusion quantification.

    Science.gov (United States)

    Chappell, Michael A; Woolrich, Mark W; Petersen, Esben T; Golay, Xavier; Payne, Stephen J

    2013-05-01

    Amongst the various implementations of arterial spin labeling MRI methods for quantifying cerebral perfusion, the QUASAR method is unique. By using a combination of labeling with and without flow suppression gradients, the QUASAR method offers the separation of macrovascular and tissue signals. This permits local arterial input functions to be defined and "model-free" analysis, using numerical deconvolution, to be used. However, it remains unclear whether arterial spin labeling data are best treated using model-free or model-based analysis. This work provides a critical comparison of these two approaches for QUASAR arterial spin labeling in the healthy brain. An existing two-component (arterial and tissue) model was extended to the mixed flow suppression scheme of QUASAR to provide an optimal model-based analysis. The model-based analysis was extended to incorporate dispersion of the labeled bolus, generally regarded as the major source of discrepancy between the two analysis approaches. Model-free and model-based analyses were compared for perfusion quantification including absolute measurements, uncertainty estimation, and spatial variation in cerebral blood flow estimates. Major sources of discrepancies between model-free and model-based analysis were attributed to the effects of dispersion and the degree to which the two methods can separate macrovascular and tissue signal. Copyright © 2012 Wiley Periodicals, Inc.

  12. Cluster analysis in kinetic modelling of the brain: A noninvasive alternative to arterial sampling

    DEFF Research Database (Denmark)

    Liptrot, Matthew George; Adams, K.H.; Martiny, L.

    2004-01-01

    by the 'within-variance' measure and by 3D visual inspection of the homogeneity of the determined clusters. The cluster-determined input curve was then used in Logan plot analysis and compared with the arterial and venous blood samples, and additionally with one of the currently used alternatives to arterial...... acts as a proof-of-principle that the use of cluster analysis on a PET data set could obviate the requirement for arterial cannulation when determining the input function for kinetic modelling of ligand binding, and that this may be a superior approach as compared to the other noninvasive alternatives......) extracted directly from dynamic positron emission tomography (PET) scans by cluster analysis. Five healthy subjects were injected with the 5HT2A- receptor ligand [18F]-altanserin and blood samples were subsequently taken from the radial artery and cubital vein. Eight regions-of-interest (ROI) TACs were...

  13. 3D Printing of Preoperative Simulation Models of a Splenic Artery Aneurysm: Precision and Accuracy.

    Science.gov (United States)

    Takao, Hidemasa; Amemiya, Shiori; Shibata, Eisuke; Ohtomo, Kuni

    2017-05-01

    Three-dimensional (3D) printing is attracting increasing attention in the medical field. This study aimed to apply 3D printing to the production of hollow splenic artery aneurysm models for use in the simulation of endovascular treatment, and to evaluate the precision and accuracy of the simulation model. From 3D computed tomography (CT) angiography data of a splenic artery aneurysm, 10 hollow models reproducing the vascular lumen were created using a fused deposition modeling-type desktop 3D printer. After filling with water, each model was scanned using T2-weighted magnetic resonance imaging for the evaluation of the lumen. All images were coregistered, binarized, and then combined to create an overlap map. The cross-sectional area of the splenic artery aneurysm and its standard deviation (SD) were calculated perpendicular to the x- and y-axes. Most voxels overlapped among the models. The cross-sectional areas were similar among the models, with SDs <0.05 cm(2). The mean cross-sectional areas of the splenic artery aneurysm were slightly smaller than those calculated from the original mask images. The maximum mean cross-sectional areas calculated perpendicular to the x- and y-axes were 3.90 cm(2) (SD, 0.02) and 4.33 cm(2) (SD, 0.02), whereas those calculated from the original mask images were 4.14 cm(2) and 4.66 cm(2), respectively. The mean cross-sectional areas of the afferent artery were, however, almost the same as those calculated from the original mask images. The results suggest that 3D simulation modeling of a visceral artery aneurysm using a fused deposition modeling-type desktop 3D printer and computed tomography angiography data is highly precise and accurate. Copyright © 2017 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  14. Implicit particle filtering for models with partial noise, and an application to geomagnetic data assimilation

    CERN Document Server

    Morzfeld, Matthias

    2011-01-01

    Implicit particle filtering is a sequential Monte Carlo method for data assim- ilation, designed to keep the number of particles manageable by focussing attention on regions of large probability. These regions are found by min- imizing, for each particle, a scalar function F of the state variables. Some previous implementations of the implicit filter rely on finding the Hessians of these functions. The calculation of the Hessians can be cumbersome if the state dimension is large or if the underlying physics are such that derivatives of F are difficult to calculate. This is the case in many geophysical applica- tions, in particular for models with partial noise, i.e. with a singular state covariance matrix. Examples of models with partial noise include stochastic partial differential equations driven by spatially smooth noise processes and models for which uncertain dynamic equations are supplemented by con- servation laws with zero uncertainty. We make the implicit particle filter applicable to such situation...

  15. Low Reynolds number turbulence modeling of blood flow in arterial stenoses.

    Science.gov (United States)

    Ghalichi, F; Deng, X; De Champlain, A; Douville, Y; King, M; Guidoin, R

    1998-01-01

    Moderate and severe arterial stenoses can produce highly disturbed flow regions with transitional and or turbulent flow characteristics. Neither laminar flow modeling nor standard two-equation models such as the kappa-epsilon turbulence ones are suitable for this kind of blood flow. In order to analyze the transitional or turbulent flow distal to an arterial stenosis, authors of this study have used the Wilcox low-Re turbulence model. Flow simulations were carried out on stenoses with 50, 75 and 86% reductions in cross-sectional area over a range of physiologically relevant Reynolds numbers. The results obtained with this low-Re turbulence model were compared with experimental measurements and with the results obtained by the standard kappa-epsilon model in terms of velocity profile, vortex length, wall shear stress, wall static pressure, and turbulence intensity. The comparisons show that results predicted by the low-Re model are in good agreement with the experimental measurements. This model accurately predicts the critical Reynolds number at which blood flow becomes transitional or turbulent distal an arterial stenosis. Most interestingly, over the Re range of laminar flow, the vortex length calculated with the low-Re model also closely matches the vortex length predicted by laminar flow modeling. In conclusion, the study strongly suggests that the proposed model is suitable for blood flow studies in certain areas of the arterial tree where both laminar and transitional/turbulent flows coexist.

  16. Poisson׳s ratio of arterial wall - Inconsistency of constitutive models with experimental data.

    Science.gov (United States)

    Skacel, Pavel; Bursa, Jiri

    2016-02-01

    Poisson׳s ratio of fibrous soft tissues is analyzed in this paper on the basis of constitutive models and experimental data. Three different up-to-date constitutive models accounting for the dispersion of fibre orientations are analyzed. Their predictions of the anisotropic Poisson׳s ratios are investigated under finite strain conditions together with the effects of specific orientation distribution functions and of other parameters. The applied constitutive models predict the tendency to lower (or even negative) out-of-plane Poisson׳s ratio. New experimental data of porcine arterial layer under uniaxial tension in orthogonal directions are also presented and compared with the theoretical predictions and other literature data. The results point out the typical features of recent constitutive models with fibres concentrated in circumferential-axial plane of arterial layers and their potential inconsistence with some experimental data. The volumetric (in)compressibility of arterial tissues is also discussed as an eventual and significant factor influencing this inconsistency.

  17. Multidimensional modeling of the stenosed carotid artery: A novel CAD approach accompanied by an extensive lumped model

    Science.gov (United States)

    Kashefi, A.; Mahdinia, M.; Firoozabadi, B.; Amirkhosravi, M.; Ahmadi, G.; Saidi, M. S.

    2014-04-01

    This study describes a multidimensional 3D/lumped parameter (LP) model which contains appropriate inflow/outflow boundary conditions in order to model the entire human arterial trees. A new extensive LP model of the entire arterial network (48 arteries) was developed including the effect of vessel diameter tapering and the parameterization of resistance, conductor and inductor variables. A computer aided-design (CAD) algorithm was proposed to efficiently handle the coupling of two or more 3D models with the LP model, and substantially lessen the coupling processing time. Realistic boundary conditions and Navier-Stokes equations in healthy and stenosed models of carotid artery bifurcation (CAB) were used to investigate the unsteady Newtonian blood flow velocity distribution in the internal carotid artery (ICA). The present simulation results agree well with previous experimental and numerical studies. The outcomes of a pure LP model and those of the coupled 3D healthy model were found to be nearly the same in both cases. Concerning the various analyzed 3D zones, the stenosis growth in the ICA was not found as a crucial factor in determining the absorbing boundary conditions. This paper demonstrates the advantages of coupling local and systemic models to comprehend physiological diseases of the cardiovascular system. [Figure not available: see fulltext.

  18. On the role of specific drug binding in modelling arterial eluting stents

    OpenAIRE

    McGinty, Sean; Pontrelli, Giuseppe

    2016-01-01

    In this paper we consider drug binding in the arterial wall following\\ud delivery by a drug-eluting stent. Whilst it is now generally accepted that a\\ud non-linear saturable reversible binding model is required to properly describe\\ud the binding process, the precise form of the binding model varies between authors.\\ud Our particular interest in this manuscript is in assessing to what extent\\ud modelling specific and non-specific binding in the arterial wall as separate\\ud phases is important...

  19. Factors associated with blood oxygen partial pressure and carbon dioxide partial pressure regulation during respiratory extracorporeal membrane oxygenation support: data from a swine model

    OpenAIRE

    Park, Marcelo; Mendes, Pedro Vitale; Costa, Eduardo Leite Vieira; Barbosa, Edzangela Vasconcelos Santos; Hirota,Adriana Sayuri; Azevedo, Luciano Cesar Pontes

    2016-01-01

    Objective The aim of this study was to explore the factors associated with blood oxygen partial pressure and carbon dioxide partial pressure. Methods The factors associated with oxygen - and carbon dioxide regulation were investigated in an apneic pig model under veno-venous extracorporeal membrane oxygenation support. A predefined sequence of blood and sweep flows was tested. Results Oxygenation was mainly associated with extracorporeal membrane oxygenation blood flow (beta coefficient = 0.0...

  20. An Efficient Implementation of Partial Condensing for Nonlinear Model Predictive Control

    DEFF Research Database (Denmark)

    Frison, Gianluca; Kouzoupis, Dimitris; Jørgensen, John Bagterp

    2016-01-01

    Partial (or block) condensing is a recently proposed technique to reformulate a Model Predictive Control (MPC) problem into a form more suitable for structure-exploiting Quadratic Programming (QP) solvers. It trades off horizon length for input vector size, and this degree of freedom can be emplo......Partial (or block) condensing is a recently proposed technique to reformulate a Model Predictive Control (MPC) problem into a form more suitable for structure-exploiting Quadratic Programming (QP) solvers. It trades off horizon length for input vector size, and this degree of freedom can...

  1. Factors associated with blood oxygen partial pressure and carbon dioxide partial pressure regulation during respiratory extracorporeal membrane oxygenation support: data from a swine model.

    Science.gov (United States)

    Park, Marcelo; Mendes, Pedro Vitale; Costa, Eduardo Leite Vieira; Barbosa, Edzangela Vasconcelos Santos; Hirota, Adriana Sayuri; Azevedo, Luciano Cesar Pontes

    2016-01-01

    The aim of this study was to explore the factors associated with blood oxygen partial pressure and carbon dioxide partial pressure. The factors associated with oxygen - and carbon dioxide regulation were investigated in an apneic pig model under veno-venous extracorporeal membrane oxygenation support. A predefined sequence of blood and sweep flows was tested. Oxygenation was mainly associated with extracorporeal membrane oxygenation blood flow (beta coefficient = 0.036mmHg/mL/min), cardiac output (beta coefficient = -11.970mmHg/L/min) and pulmonary shunting (beta coefficient = -0.232mmHg/%). Furthermore, the initial oxygen partial pressure and carbon dioxide partial pressure measurements were also associated with oxygenation, with beta coefficients of 0.160 and 0.442mmHg/mmHg, respectively. Carbon dioxide partial pressure was associated with cardiac output (beta coefficient = 3.578mmHg/L/min), sweep gas flow (beta coefficient = -2.635mmHg/L/min), temperature (beta coefficient = 4.514mmHg/ºC), initial pH (beta coefficient = -66.065mmHg/0.01 unit) and hemoglobin (beta coefficient = 6.635mmHg/g/dL). In conclusion, elevations in blood and sweep gas flows in an apneic veno-venous extracorporeal membrane oxygenation model resulted in an increase in oxygen partial pressure and a reduction in carbon dioxide partial pressure 2, respectively. Furthermore, without the possibility of causal inference, oxygen partial pressure was negatively associated with pulmonary shunting and cardiac output, and carbon dioxide partial pressure was positively associated with cardiac output, core temperature and initial hemoglobin.

  2. Fitting parametric models of diffusion MRI in regions of partial volume

    Science.gov (United States)

    Eaton-Rosen, Zach; Cardoso, M. J.; Melbourne, Andrew; Orasanu, Eliza; Bainbridge, Alan; Kendall, Giles S.; Robertson, Nicola J.; Marlow, Neil; Ourselin, Sebastien

    2016-03-01

    Regional analysis is normally done by fitting models per voxel and then averaging over a region, accounting for partial volume (PV) only to some degree. In thin, folded regions such as the cerebral cortex, such methods do not work well, as the partial volume confounds parameter estimation. Instead, we propose to fit the models per region directly with explicit PV modeling. In this work we robustly estimate region-wise parameters whilst explicitly accounting for partial volume effects. We use a high-resolution segmentation from a T1 scan to assign each voxel in the diffusion image a probabilistic membership to each of k tissue classes. We rotate the DW signal at each voxel so that it aligns with the z-axis, then model the signal at each voxel as a linear superposition of a representative signal from each of the k tissue types. Fitting involves optimising these representative signals to best match the data, given the known probabilities of belonging to each tissue type that we obtained from the segmentation. We demonstrate this method improves parameter estimation in digital phantoms for the diffusion tensor (DT) and `Neurite Orientation Dispersion and Density Imaging' (NODDI) models. The method provides accurate parameter estimates even in regions where the normal approach fails completely, for example where partial volume is present in every voxel. Finally, we apply this model to brain data from preterm infants, where the thin, convoluted, maturing cortex necessitates such an approach.

  3. A Clinical model to identify patients with high-risk coronary artery disease

    NARCIS (Netherlands)

    Y. Yang (Yelin); L. Chen (Li); Y. Yam (Yeung); S. Achenbach (Stephan); M. Al-Mallah (Mouaz); D.S. Berman (Daniel); M.J. Budoff (Matthew); F. Cademartiri (Filippo); T.Q. Callister (Tracy); H.-J. Chang (Hyuk-Jae); V.Y. Cheng (Victor); K. Chinnaiyan (Kavitha); R.C. Cury (Ricardo); A. Delago (Augustin); A. Dunning (Allison); G.M. Feuchtner (Gudrun); M. Hadamitzky (Martin); J. Hausleiter (Jörg); R.P. Karlsberg (Ronald); P.A. Kaufmann (Philipp); Y.-J. Kim (Yong-Jin); J. Leipsic (Jonathon); T.M. LaBounty (Troy); F.Y. Lin (Fay); E. Maffei (Erica); G.L. Raff (Gilbert); L.J. Shaw (Leslee); T.C. Villines (Todd); J.K. Min (James K.); B.J.W. Chow (Benjamin)

    2015-01-01

    textabstractObjectives This study sought to develop a clinical model that identifies patients with and without high-risk coronary artery disease (CAD). Background Although current clinical models help to estimate a patient's pre-test probability of obstructive CAD, they do not accurately identify th

  4. A Clinical model to identify patients with high-risk coronary artery disease

    NARCIS (Netherlands)

    Y. Yang (Yelin); L. Chen (Li); Y. Yam (Yeung); S. Achenbach (Stephan); M. Al-Mallah (Mouaz); D.S. Berman (Daniel); M.J. Budoff (Matthew); F. Cademartiri (Filippo); T.Q. Callister (Tracy); H.-J. Chang (Hyuk-Jae); V.Y. Cheng (Victor); K. Chinnaiyan (Kavitha); R.C. Cury (Ricardo); A. Delago (Augustin); A. Dunning (Allison); G.M. Feuchtner (Gudrun); M. Hadamitzky (Martin); J. Hausleiter (Jörg); R.P. Karlsberg (Ronald); P.A. Kaufmann (Philipp); Y.-J. Kim (Yong-Jin); J. Leipsic (Jonathon); T.M. LaBounty (Troy); F.Y. Lin (Fay); E. Maffei (Erica); G.L. Raff (Gilbert); L.J. Shaw (Leslee); T.C. Villines (Todd); J.K. Min (James K.); B.J.W. Chow (Benjamin)

    2015-01-01

    textabstractObjectives This study sought to develop a clinical model that identifies patients with and without high-risk coronary artery disease (CAD). Background Although current clinical models help to estimate a patient's pre-test probability of obstructive CAD, they do not accurately identify th

  5. A new beating-heart off-pump coronary artery bypass grafting training model

    NARCIS (Netherlands)

    Bouma, Wobbe; Kuijpers, Michiel; Bijleveld, Aanke; De Maat, Gijs E.; Koene, Bart M.; Erasmus, Michiel E.; Natour, Ehsan; Mariani, Massimo A.

    OBJECTIVES: Training models are essential in mastering the skills required for off-pump coronary artery bypass grafting (OPCAB). We describe a new, high-fidelity, effective and reproducible beating-heart OPCAB training model in human cadavers. METHODS: Human cadavers were embalmed according to the

  6. A structure-based model of arterial remodeling in response to sustained hypertension.

    Science.gov (United States)

    Tsamis, Alkiviadis; Stergiopulos, Nikos; Rachev, Alexander

    2009-10-01

    A novel structure-based mathematical model of arterial remodeling in response to a sustained increase in pressure is proposed. The model includes two major aspects of remodeling in a healthy matured vessel. First, the deviation of the wall stress and flow-induced shear stress from their normal physiological values drives the changes in the arterial geometry. Second, the new mass that is produced during remodeling results from an increase in the mass of smooth muscle cells and collagen fibers. The model additionally accounts for the effect of the average pulsatile strain on the recruitment of collagen fibers in load bearing. The model was used to simulate remodeling of a human thoracic aorta, and the results are in good agreement with previously published model predictions and experimental data. The model predicts that the total arterial volume rapidly increases during the early stages of remodeling and remains virtually constant thereafter, despite the continuing stress-driven geometrical remodeling. Moreover, the effects of a perfect or incomplete restoration of the arterial compliance on the remodeling outputs were analyzed. For instance, the model predicts that the pattern of the time course of the opening angle depends on the extent to which the average pulsatile strain is restored at the end of the remodeling process. Future experimental studies on the time course of compliance, opening angle, and mass fractions of collagen, elastin, and smooth muscle cells can validate and improve the introduced hypotheses of the model.

  7. An inventory model for deteriorating items with exponential declining demand and partial backlogging

    Directory of Open Access Journals (Sweden)

    Ouyang Liang-Yuh

    2005-01-01

    Full Text Available This study proposes an EOQ inventory mathematical model for deteriorating items with exponentially decreasing demand. In the model, the shortages are allowed and partially backordered. The backlogging rate is variable and dependent on the waiting time for the next replenishment. Further, we show that the minimized objective cost function is jointly convex and derive the optimal solution. A numerical example is presented to illustrate the model and the sensitivity analysis is also studied.

  8. Highly accelerated cardiac cine parallel MRI using low-rank matrix completion and partial separability model

    Science.gov (United States)

    Lyu, Jingyuan; Nakarmi, Ukash; Zhang, Chaoyi; Ying, Leslie

    2016-05-01

    This paper presents a new approach to highly accelerated dynamic parallel MRI using low rank matrix completion, partial separability (PS) model. In data acquisition, k-space data is moderately randomly undersampled at the center kspace navigator locations, but highly undersampled at the outer k-space for each temporal frame. In reconstruction, the navigator data is reconstructed from undersampled data using structured low-rank matrix completion. After all the unacquired navigator data is estimated, the partial separable model is used to obtain partial k-t data. Then the parallel imaging method is used to acquire the entire dynamic image series from highly undersampled data. The proposed method has shown to achieve high quality reconstructions with reduction factors up to 31, and temporal resolution of 29ms, when the conventional PS method fails.

  9. Iterative weighted partial spline least squares estimation in semiparametric modeling of longitudinal data

    Institute of Scientific and Technical Information of China (English)

    孙孝前; 尤进红

    2003-01-01

    In this paper we consider the estimating problem of a semiparametric regression modelling whenthe data are longitudinal. An iterative weighted partial spline least squares estimator (IWPSLSE) for the para-metric component is proposed which is more efficient than the weighted partial spline least squares estimator(WPSLSE) with weights constructed by using the within-group partial spline least squares residuals in the senseof asymptotic variance. The asymptotic normality of this IWPSLSE is established. An adaptive procedure ispresented which ensures that the iterative process stops after a finite number of iterations and produces anestimator asymptotically equivalent to the best estimator that can be obtained by using the iterative proce-dure. These results are generalizations of those in heteroscedastic linear model to the case of semiparametric regression.

  10. Simplified Method for Modeling the Impact of Arbitrary Partial Shading Conditions on PV Array Performance: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    MacAlpine, Sara; Deline, Chris

    2015-09-15

    It is often difficult to model the effects of partial shading conditions on PV array performance, as shade losses are nonlinear and depend heavily on a system's particular configuration. This work describes and implements a simple method for modeling shade loss: a database of shade impact results (loss percentages), generated using a validated, detailed simulation tool and encompassing a wide variety of shading scenarios. The database is intended to predict shading losses in crystalline silicon PV arrays and is accessed using basic inputs generally available in any PV simulation tool. Performance predictions using the database are within 1-2% of measured data for several partially shaded PV systems, and within 1% of those predicted by the full, detailed simulation tool on an annual basis. The shade loss database shows potential to considerably improve performance prediction for partially shaded PV systems.

  11. Evaluation of arterial impairment after experimental gelatin sponge embolization in a rabbit renal model

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jung Suk; Lee, Hae Gi; Chun, Ho Jong; Choi, Byung Gil; Choi, Yeong Jin [Seoul St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of)

    2015-02-15

    Arterial stenosis is a major obstacle for subsequent interventional procedures. We hypothesized that the stenosis is caused by gelatin sponge embolization and performed an experimental study in a rabbit renal model. A total of 24 rabbits were embolized with porcine gelatin sponge particles injected into the renal arteries. Four rabbits were sacrificed on 1 day, 4 days, 1 week, 2 weeks, 3 weeks, and 4 weeks after embolization. Microscopic evaluations were performed on hematoxylin-eosin and smooth muscle actin immunohistochemical stained sections. Gelatin sponge particles were mainly observed in the segmental and interlobar arteries. Transmural inflammation of the embolized arterial wall and mild thickening of the media were observed 1 week after embolization. Resorption of the gelatin sponge and organization of thrombus accompanied by foreign body reactions, were observed from 2 to 4 weeks after embolization. Microscopic images of the 3 weeks group showed vessel lumens filled mostly with organized thrombi, resulting in severe stenosis. Additionally, vessels showed a thickened intima that contained migrating smooth muscle cells and accompanying interruption of the internal elastic lamina. The migrating smooth muscle cells were distributed around the recanalized arterial lumen. Gelatin sponge embolization may induce arterial stenosis by causing organized thrombus and intimal hyperplasia, which consists of migrating smooth muscle cells and intimal collagen deposits.

  12. Relaxed incremental variational approach for the modeling of damage-induced stress hysteresis in arterial walls.

    Science.gov (United States)

    Schmidt, Thomas; Balzani, Daniel

    2016-05-01

    In this paper, a three-dimensional relaxed incremental variational damage model is proposed, which enables the description of complex softening hysteresis as observed in supra-physiologically loaded arterial tissues, and which thereby avoids a loss of convexity of the underlying formulation. The proposed model extends the relaxed formulation of Balzani and Ortiz [2012. Relaxed incremental variational formulation for damage at large strains with application to fiber-reinforced materials and materials with truss-like microstructures. Int. J. Numer. Methods Eng. 92, 551-570], such that the typical stress-hysteresis observed in arterial tissues under cyclic loading can be described. This is mainly achieved by constructing a modified one-dimensional model accounting for cyclic loading in the individual fiber direction and numerically homogenizing the response taking into account a fiber orientation distribution function. A new solution strategy for the identification of the convexified stress potential is proposed based on an evolutionary algorithm which leads to an improved robustness compared to solely Newton-based optimization schemes. In order to enable an efficient adjustment of the new model to experimentally observed softening hysteresis, an adjustment scheme using a surrogate model is proposed. Therewith, the relaxed formulation is adjusted to experimental data in the supra-physiological domain of the media and adventitia of a human carotid artery. The performance of the model is then demonstrated in a finite element example of an overstretched artery. Although here three-dimensional thick-walled atherosclerotic arteries are considered, it is emphasized that the formulation can also directly be applied to thin-walled simulations of arteries using shell elements or other fiber-reinforced biomembranes.

  13. Implementing The Automated Phases Of The Partially-Automated Digital Triage Process Model

    Directory of Open Access Journals (Sweden)

    Gary D Cantrell

    2012-12-01

    Full Text Available Digital triage is a pre-digital-forensic phase that sometimes takes place as a way of gathering quick intelligence. Although effort has been undertaken to model the digital forensics process, little has been done to date to model digital triage. This work discuses the further development of a model that does attempt to address digital triage the Partially-automated Crime Specific Digital Triage Process model. The model itself will be presented along with a description of how its automated functionality was implemented to facilitate model testing.

  14. Towards the virtual artery: a multiscale model for vascular physiology at the physics-chemistry-biology interface

    Science.gov (United States)

    Hoekstra, Alfons G.; Alowayyed, Saad; Lorenz, Eric; Melnikova, Natalia; Mountrakis, Lampros; van Rooij, Britt; Svitenkov, Andrew; Závodszky, Gábor; Zun, Pavel

    2016-11-01

    This discussion paper introduces the concept of the Virtual Artery as a multiscale model for arterial physiology and pathologies at the physics-chemistry-biology (PCB) interface. The cellular level is identified as the mesoscopic level, and we argue that by coupling cell-based models with other relevant models on the macro- and microscale, a versatile model of arterial health and disease can be composed. We review the necessary ingredients, both models of arteries at many different scales, as well as generic methods to compose multiscale models. Next, we discuss how this can be combined into the virtual artery. Finally, we argue that the concept of models at the PCB interface could or perhaps should become a powerful paradigm, not only as in our case for studying physiology, but also for many other systems that have such PCB interfaces. This article is part of the themed issue 'Multiscale modelling at the physics-chemistry-biology interface'.

  15. Experimental parameter estimation method for nonlinear viscoelastic composite material models: an application on arterial tissue.

    Science.gov (United States)

    Sunbuloglu, Emin; Bozdag, Ergun; Toprak, Tuncer; Islak, Civan

    2013-01-01

    This study is aimed at setting a method of experimental parameter estimation for large-deforming nonlinear viscoelastic continuous fibre-reinforced composite material model. Specifically, arterial tissue was investigated during experimental research and parameter estimation studies, due to medical, scientific and socio-economic importance of soft tissue research. Using analytical formulations for specimens under combined inflation/extension/torsion on thick-walled cylindrical tubes, in vitro experiments were carried out with fresh sheep arterial segments, and parameter estimation procedures were carried out on experimental data. Model restrictions were pointed out using outcomes from parameter estimation. Needs for further studies that can be developed are discussed.

  16. On the Existence and Uniqueness of JML Estimates for the Partial Credit Model

    Science.gov (United States)

    Bertoli-Barsotti, Lucio

    2005-01-01

    A necessary and sufficient condition is given in this paper for the existence and uniqueness of the maximum likelihood (the so-called joint maximum likelihood) estimate of the parameters of the Partial Credit Model. This condition is stated in terms of a structural property of the pattern of the data matrix that can be easily verified on the basis…

  17. Systematic model development for partial nitrification of landfill leachate in a SBR

    DEFF Research Database (Denmark)

    Ganigue, R.; Volcke, E.I.P.; Puig, S.

    2010-01-01

    This study deals with partial nitrification in a sequencing batch reactor (PN-SBR) treating raw urban landfill leachate. In order to enhance process insight (e.g. quantify interactions between aeration, CO2 stripping, alkalinity, pH, nitrification kinetics), a mathematical model has been set up...

  18. Inference in partially identified models with many moment inequalities using Lasso

    DEFF Research Database (Denmark)

    Bugni, Federico A.; Caner, Mehmet; Kock, Anders Bredahl;

    This paper considers the problem of inference in a partially identified moment (in)equality model with possibly many moment inequalities. Our contribution is to propose a novel two-step new inference method based on the combination of two ideas. On the one hand, our test statistic and critical va...

  19. Multigroup Analysis in Partial Least Squares (PLS) Path Modeling: Alternative Methods and Empirical Results

    NARCIS (Netherlands)

    Sarstedt, Marko; Henseler, Jörg; Ringle, Christian M.

    2011-01-01

    Purpose – Partial least squares (PLS) path modeling has become a pivotal empirical research method in international marketing. Owing to group comparisons' important role in research on international marketing, we provide researchers with recommendations on how to conduct multigroup analyses in PLS p

  20. Application of partial differential equation modeling of the control/structural dynamics of flexible spacecraft

    Science.gov (United States)

    Taylor, Lawrence W., Jr.; Rajiyah, H.

    1991-01-01

    Partial differential equations for modeling the structural dynamics and control systems of flexible spacecraft are applied here in order to facilitate systems analysis and optimization of these spacecraft. Example applications are given, including the structural dynamics of SCOLE, the Solar Array Flight Experiment, the Mini-MAST truss, and the LACE satellite. The development of related software is briefly addressed.

  1. Generic Form of Bayesian Monte Carlo For Models With Partial Monotonicity

    NARCIS (Netherlands)

    Rajabalinejad, M.

    2012-01-01

    This paper presents a generic method for the safety assessments of models with partial monotonicity. For this purpose, a Bayesian interpolation method is developed and implemented in the Monte Carlo process. integrated approach is the generalization of the recently developed techniques used in safet

  2. Application of partial differential equation modeling of the control/structural dynamics of flexible spacecraft

    Science.gov (United States)

    Taylor, Lawrence W., Jr.; Rajiyah, H.

    Partial differential equations for modeling the structural dynamics and control systems of flexible spacecraft are applied here in order to facilitate systems analysis and optimization of these spacecraft. Example applications are given, including the structural dynamics of SCOLE, the Solar Array Flight Experiment, the Mini-MAST truss, and the LACE satellite. The development of related software is briefly addressed.

  3. Generic form of Bayesian Monte Carlo for models with partial monotonicity

    NARCIS (Netherlands)

    Rajabalinejad, M.; Spitas, C.

    2012-01-01

    This paper presents a generic method for the safety assessments of models with partial monotonicity. For this purpose, a Bayesian interpolation method is developed and implemented in the Monte Carlo process. integrated approach is the generalization of the recently developed techniques used in safet

  4. Dynamic model for ammonia volatilization in housing with partially slatted floors, for fattening pigs

    NARCIS (Netherlands)

    Aarnink, A.J.A.; Elzing, A.

    1998-01-01

    A dynamic model was developed to simulate the ammonia volatilization from pig housing with partially slatted floors, where no litter is used. Simulated ammonia emission levels were compared with measured levels for 1 day in each 3-week period during two fattening periods of 15 weeks (one in winter a

  5. Empirical Likelihood Based Variable Selection for Varying Coefficient Partially Linear Models with Censored Data

    Institute of Scientific and Technical Information of China (English)

    Peixin ZHAO

    2013-01-01

    In this paper,we consider the variable selection for the parametric components of varying coefficient partially linear models with censored data.By constructing a penalized auxiliary vector ingeniously,we propose an empirical likelihood based variable selection procedure,and show that it is consistent and satisfies the sparsity.The simulation studies show that the proposed variable selection method is workable.

  6. Parent Ratings of ADHD Symptoms: Generalized Partial Credit Model Analysis of Differential Item Functioning across Gender

    Science.gov (United States)

    Gomez, Rapson

    2012-01-01

    Objective: Generalized partial credit model, which is based on item response theory (IRT), was used to test differential item functioning (DIF) for the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.), inattention (IA), and hyperactivity/impulsivity (HI) symptoms across boys and girls. Method: To accomplish this, parents completed…

  7. A partial budget model to estimate economic benefits of Lactational treatment of subclinical Staphylococcus aureus mastitis

    NARCIS (Netherlands)

    Swinkels, J.M.; Hogeveen, H.; Zadoks, R.N.

    2005-01-01

    linical Staphylococcus aureus mastitis is rarely treated during lactation because it is widely believed to be uneconomical, although there are no economic studies that support this view. Partial budgeting was used to develop a deterministic simulation model to estimate the net cost or benefit of ant

  8. Residual stress distribution in a lamellar model of the arterial wall.

    Science.gov (United States)

    Haghighipour, Nooshin; Tafazzoli-Shadpour, Mohammad; Avolio, Albert

    2010-01-01

    Excessive wall circumferential stress in arteries caused by luminal pressure leads to endothelial damage and clinical consequences. In addition to circumferential stress, arterial wall contains residual stress with compressive and tensile components on intima and adventitia sides. The intimal compressive component compensates part of tensile stress induced by blood pressure, hence reduces severity of endothelial tension. The opening angle caused by radial cut of arterial ring defines residual stress. In this study, finite element modelling is used to evaluate residual stress in a lamellar model of human aorta with differing opening angle and elastic modulus. Results show non-linear residual stress profiles across wall thickness, influenced by structural and mechanical parameters. Elevation of opening angle from 50° to 90° leads to increase of intimal compressive component compensating up to 32.6% of the pressure-induced tensile stress. Results may be applied in study of endothelial injury caused by excessive stress in situations such as aging, hypertension and atherosclerosis.

  9. Effects of pressure-dependent segmental arterial compliance and postural changes on pulse wave transmission in an arterial model of the human upper limb.

    Science.gov (United States)

    Xu, Ke; Butlin, Mark; Avolio, Alberto P

    2011-01-01

    With increasing interest in the effect of postural changes on arterial blood pressure and vascular properties, it is important to understand effects of pressure-dependent arterial compliance. This study investigates effects of pressure-dependent compliance on pulse wave velocity (PWVar), pressure wave shape, and transmission characteristics in an arterial model of the human arm from heart to radial artery from supine to standing. Estimated central pressure waveform was used as the input for the model, calculated using a validated transfer function (SphygmoCor, AtCor Medical) from recorded radial pulses in 10 healthy male subjects (53.8 ± 7.9 years) during 0, 30, 60 and 90 degree head-up tilt. A 5-segment linear model was optimized using estimated central and recorded radial arterial pulse; each segment represented by an equivalent inductance, resistance and capacitance (compliance (C)) Pressure-dependent compliance (C(P)=a · e(b · P) was added to develop a nonlinear model, and the radial pulse calculated. Comparison of the radial pulse calculated by the linear and nonlinear models showed no statistical difference in systolic, diastolic, mean, and pulse pressure in any position of tilt. However, waveform shape was increasingly divergent at higher angles of tilt (RMS error 2.3 ± 1.2 mmHg supine, 6.5 ± 3.0 mmHg standing) as was PWVar (0% increase from supine to standing in the linear model, 16.7% increase in nonlinear model). Fourier analysis demonstrated peak amplitude of transmission being at higher frequencies and phase delay being lower in the nonlinear model relative to the linear model. Pressure-dependent arterial compliance, whilst having no effect on peak values of pressure, has significant effects on waveform shape and transmission speed, especially with a more upright position.

  10. Shock structure simulation using hyperbolic moment models in partially-conservative form

    Science.gov (United States)

    Koellermeier, Julian; Torrilhon, Manuel

    2016-11-01

    The Boltzmann equation is often used to model rarefied gas flow in the transition or kinetic regime for moderate to large Knudsen numbers. However, standard moment methods like Grad's approach lack hyperbolicity of the equations. We point out the failure of Grad's method and overcome the deficiencies with the help of the new hyperbolic moment models called QBME and HME, derived by an operator projection framework. The new model equations are in partially-conservative form meaning that a subset of the equations cannot be written in conservative form due to some changes in these equations. This leads to additional numerical difficulties. The influence of the partially-conservative terms on the solution is analyzed and we present a numerical scheme for the solution of the partially-conservative PDE systems, namely the PRICE-C scheme by Canestrelli. Furthermore, a shock structure test case is used to compare the accuracy of the different hyperbolic moment models to a discrete velocity reference solution. The results show that the new hyperbolic models achieve higher accuracy than the standard Grad model despite the fact that the model equations cannot be fully written in conservative form.

  11. Efficiency of a mathematical model in generating CAD/CAM-partial crowns with natural tooth morphology.

    Science.gov (United States)

    Ender, Andreas; Mörmann, Werner H; Mehl, Albert

    2011-04-01

    The "biogeneric tooth model" can be used for computer-aided design (CAD) of the occlusal surface of dental restorations. From digital 3D-data, it automatically retrieves a morphology matching the natural surface left after preparation. This study evaluates the potential of this method for generating well-matched and well-adjusted CAD/computer-aided manufacturing (CAM) fabricated partial crowns. Twelve models with partial crown preparations were mounted into an articulator. Partial crowns were designed with the Cerec 3D CAD software based on the biogeneric tooth model (Biog.CAD) and, for control, with a conventional data-based Cerec 3D CAD software (Conv.CAD). The design time was measured, and the naturalness of the morphology was visually assessed. The restorations were milled, cemented on the models, and the vertical discrepancy and the time for final occlusal adjustment were measured. The Biog.CAD software offered a significantly higher naturalness (up to 225 to 11 scores) and was significantly faster by 251 (± 78) s in designing partial crowns (p < 0.01) compared to Conv.CAD software. Vertical discrepancy, 0.52 (± 0.28) mm for Conv.CAD and 0.46 (± 0.19)mm for Biog.CAD, and occlusal adjustment time, 118 (± 132)s for Conv.CAD and 102 (± 77)s for Biog.CAD, did not differ significantly. In conclusion, the biogeneric tooth model is able to generate occlusal morphology of partial crowns in a fully automated process with higher naturalness compared to conventional interactive CAD software.

  12. Derivation of models of compressible miscible displacement in partially fractured reservoirs

    Directory of Open Access Journals (Sweden)

    Catherine Choquet

    2007-07-01

    Full Text Available We derive rigorously homogenized models for the displacement of one compressible miscible fluid by another in fractured porous media. We denote by $epsilon$ the characteristic size of the heterogeneity in the medium. A parameter $alpha in [0,1]$ characterizes the cracking degree of the rock. We carefully define an adapted microscopic model which is scaled by appropriate powers of $epsilon$. We then study its limit as $epsilon o 0$. Assuming a totally fractured or a partially fractured medium, we obtain two effective macroscopic limit models. The first one is a double porosity model. The second one is of single porosity type but it still contains some effects due to the partial storage in the matrix part. The convergence is shown using two-scale convergence techniques.

  13. The partial duration series method in regional index-flood modeling

    DEFF Research Database (Denmark)

    Madsen, Henrik; Rosbjerg, Dan

    1997-01-01

    A regional index-flood method based on the partial duration series model is introduced. The model comprises the assumptions of a Poisson-distributed number of threshold exceedances and generalized Pareto (GP) distributed peak magnitudes. The regional T-year event estimator is based on a regional...... preferable to at-site estimation in moderately heterogeneous and homogeneous regions for large sample sizes. Modest intersite dependence has only a small effect on the performance of the regional index-flood estimator....

  14. Single Parameter Model for Free Recall And the Nature of Partially Filled Working Memory

    OpenAIRE

    Tarnow, Dr Eugen

    2009-01-01

    I present a single parameter model of free recall and fit the one parameter, the probability per time unit of an item in working memory entering the next memory store (similar to Atkinson and Shiffrin, 1968), to the original Murdock (1962) data. Working memory is modeled as having space for a maximum of 4 items (Cowan, 2001). The first four probability values convey precise information about how items in the partially filled working memory enter the next memory store. In particular, one ...

  15. A partially ionized plasma modeling; Un modele de plasma partiellement ionise

    Energy Technology Data Exchange (ETDEWEB)

    Le Thanh, K.C.; Raviart, P.A

    2003-07-01

    We propose a model for the partially ionized plasma sheaths near the anode of an anodic spot electric arc where the cathode is considered as an electron emitter. A fluid description takes into account the heating and the ionization of the plasma induced by the electron beam. As physical hypothesis we assume that the condition of charge neutrality is valid. According that the electron mass can be neglected compared to the ion mass, we can assume that ions and atoms have the same velocity and the same temperature. Electrons and heavy particles are then regarded as two separate fluids coexisting in the plasma. Governing equations are then multi-fluid equations with relaxation correction to the local thermodynamic equilibrium (LTE) and heating by Joule effect. Equations are solved by an operator splitting procedure. That is we first discretize the homogeneous conservation laws (i.e. without source terms) by a finite volume method. The second step is to solve the ordinary differential system (i.e, governing equation without transport terms) with an implicit scheme. (authors)

  16. Multidimensional model of apathy in older adults using partial least squares--path modeling.

    Science.gov (United States)

    Raffard, Stéphane; Bortolon, Catherine; Burca, Marianna; Gely-Nargeot, Marie-Christine; Capdevielle, Delphine

    2016-06-01

    Apathy defined as a mental state characterized by a lack of goal-directed behavior is prevalent and associated with poor functioning in older adults. The main objective of this study was to identify factors contributing to the distinct dimensions of apathy (cognitive, emotional, and behavioral) in older adults without dementia. One hundred and fifty participants (mean age, 80.42) completed self-rated questionnaires assessing apathy, emotional distress, anticipatory pleasure, motivational systems, physical functioning, quality of life, and cognitive functioning. Data were analyzed using partial least squares variance-based structural equation modeling in order to examine factors contributing to the three different dimensions of apathy in our sample. Overall, the different facets of apathy were associated with cognitive functioning, anticipatory pleasure, sensitivity to reward, and physical functioning, but the contribution of these different factors to the three dimensions of apathy differed significantly. More specifically, the impact of anticipatory pleasure and physical functioning was stronger for the cognitive than for emotional apathy. Conversely, the impact of sensibility to reward, although small, was slightly stronger on emotional apathy. Regarding behavioral apathy, again we found similar latent variables except for the cognitive functioning whose impact was not statistically significant. Our results highlight the need to take into account various mechanisms involved in the different facets of apathy in older adults without dementia, including not only cognitive factors but also motivational variables and aspects related to physical disability. Clinical implications are discussed.

  17. Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress

    NARCIS (Netherlands)

    Harms, M.P.M.; Wesseling, K.H.; Pott, F.; Jenstrup, M.; Goudoever, J. van; Secher, N.H.; Lieshout, J.J. van

    1999-01-01

    The relationship between aortic flow and pressure is described by a three-element model of the arterial input impedance, including continuous correction for variations in the diameter and the compliance of the aorta (Modelflow). We computed the aortic flow from arterial pressure by this model, and

  18. A NEW UNSTEADY THREE DIMENSIONAL MODEL FOR MACROMOLECULAR TRANSPORT AND WATER FILTRATION ACROSS THE ARTERIAL WALL

    Institute of Scientific and Technical Information of China (English)

    黄浩; 温功碧

    2001-01-01

    A new unsteady three-dimensional convective-diffusive mathematical model for the transportation of macromolecules and water across the arterial wall was proposed . After the formation of leaky junctions due to the mitosis of endothelial cell of the arterial wall, the macromolecular transport happens surrounding the leaky cells. The arterial wall was divided into four layers: the endothelial layer, the subendothelial intima, the internal elastic lamina and the media for the convenience of research. The time-dependent concentration growth,the effect of the shape of endothelial cell and the effect of physiological parameters were analyzed. The analytical solution of velocity field and pressure field of water flow across the arterial wall were obtained; and concentration distribution of three macromolecules ; LDL,HRP and Albumin, were calculated with numerical simulation method. The new theory predicts, the maximum and distribution areas of time dependent concentration with round shape endothelial cell are both larger than that with ellipse-shape endothelial cell. The model also predicts the concentration growth is much alike that of a two-dimensional model and it shows that the concentration reaches its peak at the leaky junction where atherosclerotic formation frequently occurs and falls down rapidly in a limited area beginning from its earlier time growth to the state when macromolecular transfer approaches steadily. These predictions of the new model are in agreement with the experimental observation for the growth and concentration distribution of LDL and Albumin.

  19. Assessment of collateral artery function and growth in a pig model of stepwise coronary occlusion

    NARCIS (Netherlands)

    de Groot, Daphne; Grundmann, Sebastian; Timmers, Leo; Pasterkamp, Gerard; Hoefer, Imo E.

    2011-01-01

    de Groot D, Grundmann S, Timmers L, Pasterkamp G, Hoefer IE. Assessment of collateral artery function and growth in a pig model of stepwise coronary occlusion. Am J Physiol Heart Circ Physiol 300: H408-H414, 2011. First published October 15, 2010; doi: 10.1152/ajpheart.00070.2010.-Therapeutic stimul

  20. Arterial waveguide model for shear wave elastography: implementation and in vitro validation

    Science.gov (United States)

    Vaziri Astaneh, Ali; Urban, Matthew W.; Aquino, Wilkins; Greenleaf, James F.; Guddati, Murthy N.

    2017-07-01

    Arterial stiffness is found to be an early indicator of many cardiovascular diseases. Among various techniques, shear wave elastography has emerged as a promising tool for estimating local arterial stiffness through the observed dispersion of guided waves. In this paper, we develop efficient models for the computational simulation of guided wave dispersion in arterial walls. The models are capable of considering fluid-loaded tubes, immersed in fluid or embedded in a solid, which are encountered in in vitro/ex vivo, and in vivo experiments. The proposed methods are based on judiciously combining Fourier transformation and finite element discretization, leading to a significant reduction in computational cost while fully capturing complex 3D wave propagation. The developed methods are implemented in open-source code, and verified by comparing them with significantly more expensive, fully 3D finite element models. We also validate the models using the shear wave elastography of tissue-mimicking phantoms. The computational efficiency of the developed methods indicates the possibility of being able to estimate arterial stiffness in real time, which would be beneficial in clinical settings.

  1. A novel human artery model to assess the magnetic accumulation of SPIONs under flow conditions

    Science.gov (United States)

    Janikowska, Agata; Matuszak, Jasmin; Lyer, Stefan; Schreiber, Eveline; Unterweger, Harald; Zaloga, Jan; Groll, Jürgen; Alexiou, Christoph; Cicha, Iwona

    2017-01-01

    Magnetic targeting utilises the properties of superparamagnetic iron oxide nanoparticles (SPIONs) to accumulate particles in specified vasculature regions under an external magnetic field. As the behaviour of circulating particles varies depending on nanoparticle characteristics, magnetic field strength and flow dynamics, we established an improved ex vivo model in order to estimate the magnetic capture of SPIONs in physiological-like settings. We describe here a new, easy to handle ex vivo model of human umbilical artery. Using this model, the magnetic targeting of different types of SPIONs under various external magnetic field gradients and flow conditions was investigated by atomic emission spectroscopy and histology. Among tested particles, SPION-1 with lauric acid shell had the largest capacity to accumulate at the specific artery segment. SPION-2 (lauric acid/albumin-coated) were also successfully targeted, although the observed peak in the iron content under the tip of the magnet was smaller than for SPION-1. In contrast, we did not achieve magnetic accumulation of dextran-coated SPION-3. Taken together, the umbilical artery model constitutes a time- and cost-efficient, 3R-compliant tool to assess magnetic targeting of SPIONs under flow. Our results further imply the possibility of an efficient in vivo targeting of certain types of SPIONs to superficial arteries. PMID:28176885

  2. An innovative method to measure the peripheral arterial elasticity: spring constant modeling based on the arterial pressure wave with radial vibration.

    Science.gov (United States)

    Wei, Ching-Chuan

    2011-11-01

    In this study, we propose an innovative method for the direct measurement of the peripheral artery elasticity using a spring constant model, based on the arterial pressure wave equation, vibrating in a radial direction. By means of the boundary condition of the pressure wave equation at the maximum peak, we can derive the spring constant used for evaluating peripheral arterial elasticity. The calculated spring constants of six typical subjects show a coincidence with their proper arterial elasticities. Furthermore, the comparison between the spring constant method and pulse wave velocity (PWV) was investigated in 70 subjects (21-64 years, 47 normotensives and 23 hypertensives). The results reveal a significant negative correlation for the spring constant vs. PWV (correlation coefficient = -0.663, p constant method to assess the arterial elasticity is carefully verified, and it is shown to be effective as well as fast. This method should be useful for healthcare, not only in improving clinical diagnosis of arterial stiffness but also in screening subjects for early evidence of cardio-vascular diseases and in monitoring responses to therapy in the future.

  3. Middle Cerebral Artery Occlusion Model in Rodents: Methods and Potential Pitfalls

    Directory of Open Access Journals (Sweden)

    Fudong Liu

    2011-01-01

    Full Text Available A variety of animal models have been developed for modeling ischemic stroke. The middle cerebral artery occlusion (MCAO model has been utilized extensively, especially in rodents. While the MCAO model provides stroke researchers with an excellent platform to investigate the disease, controversial or even paradoxical results are occasionally seen in the literature utilizing this model. Various factors exert important effects on the outcome in this stroke model, including the age and sex of the animal examined. This paper discusses emerging information on the effects of age and sex on ischemic outcomes after MCAO, with an emphasis on mouse models of stroke.

  4. A logistic regression model of Coronary Artery Disease among Male Patients in Punjab

    Directory of Open Access Journals (Sweden)

    Sohail Chand

    2005-07-01

    Full Text Available This is a cross-sectional retrospective study of 308 male patients, who were presented first time for coronary angiography at the Punjab Institute of Cardiology. The mean age was 50.97 + 9.9 among male patients. As the response variable coronary artery disease (CAD was a binary variable, logistic regression model was fitted to predict the Coronary Artery Disease with the help of significant risk factors. Age, Chest pain, Diabetes Mellitus, Smoking and Lipids are resulted as significant risk factors associated with CAD among male population.

  5. Inventory Model with Partial Backordering When Backordered Customers Delay Purchase after Stockout-Restoration

    Directory of Open Access Journals (Sweden)

    Ren-Qian Zhang

    2016-01-01

    Full Text Available Many inventory models with partial backordering assume that the backordered demand must be filled instantly after stockout restoration. In practice, however, the backordered customers may successively revisit the store because of the purchase delay behavior, producing a limited backorder demand rate and resulting in an extra inventory holding cost. Hence, in this paper we formulate the inventory model with partial backordering considering the purchase delay of the backordered customers and assuming that the backorder demand rate is proportional to the remaining backordered demand. Particularly, we model the problem by introducing a new inventory cost component of holding the backordered items, which has not been considered in the existing models. We propose an algorithm with a two-layer structure based on Lipschitz Optimization (LO to minimize the total inventory cost. Numerical experiments show that the proposed algorithm outperforms two benchmarks in both optimality and efficiency. We also observe that the earlier the backordered customer revisits the store, the smaller the inventory cost and the fill rate are, but the longer the order cycle is. In addition, if the backordered customers revisit the store without too much delay, the basic EOQ with partial backordering approximates our model very well.

  6. Model-based reinforcement learning for partially observable games with sampling-based state estimation.

    Science.gov (United States)

    Fujita, Hajime; Ishii, Shin

    2007-11-01

    Games constitute a challenging domain of reinforcement learning (RL) for acquiring strategies because many of them include multiple players and many unobservable variables in a large state space. The difficulty of solving such realistic multiagent problems with partial observability arises mainly from the fact that the computational cost for the estimation and prediction in the whole state space, including unobservable variables, is too heavy. To overcome this intractability and enable an agent to learn in an unknown environment, an effective approximation method is required with explicit learning of the environmental model. We present a model-based RL scheme for large-scale multiagent problems with partial observability and apply it to a card game, hearts. This game is a well-defined example of an imperfect information game and can be approximately formulated as a partially observable Markov decision process (POMDP) for a single learning agent. To reduce the computational cost, we use a sampling technique in which the heavy integration required for the estimation and prediction can be approximated by a plausible number of samples. Computer simulation results show that our method is effective in solving such a difficult, partially observable multiagent problem.

  7. APPLICATION OF PARTIAL LEAST SQUARES REGRESSION FOR AUDIO-VISUAL SPEECH PROCESSING AND MODELING

    Directory of Open Access Journals (Sweden)

    A. L. Oleinik

    2015-09-01

    Full Text Available Subject of Research. The paper deals with the problem of lip region image reconstruction from speech signal by means of Partial Least Squares regression. Such problems arise in connection with development of audio-visual speech processing methods. Audio-visual speech consists of acoustic and visual components (called modalities. Applications of audio-visual speech processing methods include joint modeling of voice and lips’ movement dynamics, synchronization of audio and video streams, emotion recognition, liveness detection. Method. Partial Least Squares regression was applied to solve the posed problem. This method extracts components of initial data with high covariance. These components are used to build regression model. Advantage of this approach lies in the possibility of achieving two goals: identification of latent interrelations between initial data components (e.g. speech signal and lip region image and approximation of initial data component as a function of another one. Main Results. Experimental research on reconstruction of lip region images from speech signal was carried out on VidTIMIT audio-visual speech database. Results of the experiment showed that Partial Least Squares regression is capable of solving reconstruction problem. Practical Significance. Obtained findings give the possibility to assert that Partial Least Squares regression is successfully applicable for solution of vast variety of audio-visual speech processing problems: from synchronization of audio and video streams to liveness detection.

  8. Mathematical modelling of atheroma plaque formation and development in coronary arteries

    Science.gov (United States)

    Cilla, Myriam; Peña, Estefanía; Martínez, Miguel A.

    2014-01-01

    Atherosclerosis is a vascular disease caused by inflammation of the arterial wall, which results in the accumulation of low-density lipoprotein (LDL) cholesterol, monocytes, macrophages and fat-laden foam cells at the place of the inflammation. This process is commonly referred to as plaque formation. The evolution of the atherosclerosis disease, and in particular the influence of wall shear stress on the growth of atherosclerotic plaques, is still a poorly understood phenomenon. This work presents a mathematical model to reproduce atheroma plaque growth in coronary arteries. This model uses the Navier–Stokes equations and Darcy's law for fluid dynamics, convection–diffusion–reaction equations for modelling the mass balance in the lumen and intima, and the Kedem–Katchalsky equations for the interfacial coupling at membranes, i.e. endothelium. The volume flux and the solute flux across the interface between the fluid and the porous domains are governed by a three-pore model. The main species and substances which play a role in early atherosclerosis development have been considered in the model, i.e. LDL, oxidized LDL, monocytes, macrophages, foam cells, smooth muscle cells, cytokines and collagen. Furthermore, experimental data taken from the literature have been used in order to physiologically determine model parameters. The mathematical model has been implemented in a representative axisymmetric geometrical coronary artery model. The results show that the mathematical model is able to qualitatively capture the atheroma plaque development observed in the intima layer. PMID:24196695

  9. Mathematical modelling of atheroma plaque formation and development in coronary arteries.

    Science.gov (United States)

    Cilla, Myriam; Peña, Estefanía; Martínez, Miguel A

    2014-01-06

    Atherosclerosis is a vascular disease caused by inflammation of the arterial wall, which results in the accumulation of low-density lipoprotein (LDL) cholesterol, monocytes, macrophages and fat-laden foam cells at the place of the inflammation. This process is commonly referred to as plaque formation. The evolution of the atherosclerosis disease, and in particular the influence of wall shear stress on the growth of atherosclerotic plaques, is still a poorly understood phenomenon. This work presents a mathematical model to reproduce atheroma plaque growth in coronary arteries. This model uses the Navier-Stokes equations and Darcy's law for fluid dynamics, convection-diffusion-reaction equations for modelling the mass balance in the lumen and intima, and the Kedem-Katchalsky equations for the interfacial coupling at membranes, i.e. endothelium. The volume flux and the solute flux across the interface between the fluid and the porous domains are governed by a three-pore model. The main species and substances which play a role in early atherosclerosis development have been considered in the model, i.e. LDL, oxidized LDL, monocytes, macrophages, foam cells, smooth muscle cells, cytokines and collagen. Furthermore, experimental data taken from the literature have been used in order to physiologically determine model parameters. The mathematical model has been implemented in a representative axisymmetric geometrical coronary artery model. The results show that the mathematical model is able to qualitatively capture the atheroma plaque development observed in the intima layer.

  10. Non-invasive accurate measurement of arterial PCO2 in a pediatric animal model.

    Science.gov (United States)

    Fierstra, Jorn; Winter, Jeff D; Machina, Matthew; Lukovic, Jelena; Duffin, James; Kassner, Andrea; Fisher, Joseph A

    2013-04-01

    The PCO2 in arterial blood (PaCO2) is a good parameter for monitoring ventilation and acid-base changes in ventilated patients, but its measurement is invasive and difficult to obtain in small children. Attempts have been made to use the partial pressure of CO2 in end-tidal gas (PETCO2), as a noninvasive surrogate for PaCO2. Studies have revealed that, unfortunately, the differences between PETCO2 and PaCO2 are too variable to be clinically useful. We hypothesized that end-inspiratory rebreathing, previously shown to equalize PETCO2 and PaCO2 in spontaneously breathing humans, would also be effective with positive pressure ventilation. Eight newborn Yorkshire pigs were mechanically ventilated via a partial rebreathing circuit to implement end-inspiratory rebreathing. Arterial blood was sampled and tested for PaCO2. A variety of alveolar ventilations resulting in different combinations of end-tidal PCO2 (30-50 mmHg) and PO2 (35-500 mmHg) were tested for differences between PETCO2 and PaCO2 (PET-aCO2). The PET-aCO2 of all samples was (mean ± 1.96 SD) 0.4 ± 2.7 mmHg. Our study demonstrates that, in ventilated juvenile animals, end-inspiratory rebreathing maintains PET-aCO2 to what would be a clinically useful range. If verified clinically, this approach could open the way for non-invasive monitoring of arterial PCO2 in critically ill patients.

  11. Quantifying uncertainty in partially specified biological models: how can optimal control theory help us?

    Science.gov (United States)

    Adamson, M W; Morozov, A Y; Kuzenkov, O A

    2016-09-01

    Mathematical models in biology are highly simplified representations of a complex underlying reality and there is always a high degree of uncertainty with regards to model function specification. This uncertainty becomes critical for models in which the use of different functions fitting the same dataset can yield substantially different predictions-a property known as structural sensitivity. Thus, even if the model is purely deterministic, then the uncertainty in the model functions carries through into uncertainty in model predictions, and new frameworks are required to tackle this fundamental problem. Here, we consider a framework that uses partially specified models in which some functions are not represented by a specific form. The main idea is to project infinite dimensional function space into a low-dimensional space taking into account biological constraints. The key question of how to carry out this projection has so far remained a serious mathematical challenge and hindered the use of partially specified models. Here, we propose and demonstrate a potentially powerful technique to perform such a projection by using optimal control theory to construct functions with the specified global properties. This approach opens up the prospect of a flexible and easy to use method to fulfil uncertainty analysis of biological models.

  12. Two analytical solutions for a model of pulsed arterial spin labeling with randomized blood arrival times

    Science.gov (United States)

    Hrabe, J.; Lewis, D. P.

    2004-03-01

    A fairly general theoretical model for pulsed arterial spin labeling perfusion methods has been available for some time but analytical solutions were derived for only a small number of arterial blood input functions. These mostly assumed a sudden and simultaneous arrival of the tagged blood into the imaged region. More general cases had to be handled numerically. We present analytical solutions for two more realistic arterial input functions. They both allow the arrival times of the molecules of tagged arterial blood to be statistically distributed. We consider cases of (1) a uniform distribution on a finite time interval and (2) a normal distribution characterized by its mean and standard deviation. These models are physiologically meaningful because the statistical nature of the arrival times reflects the distribution of velocities and path lengths that the blood water molecules undertake from the tagging region to the imaged region. The model parameters can be estimated from the measured dependency of the perfusion signal on the tag inversion time.

  13. Sieve M-estimation for semiparametric varying-coefficient partially linear regression model

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This article considers a semiparametric varying-coefficient partially linear regression model.The semiparametric varying-coefficient partially linear regression model which is a generalization of the partially linear regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable.A sieve M-estimation method is proposed and the asymptotic properties of the proposed estimators are discussed.Our main object is to estimate the nonparametric component and the unknown parameters simultaneously.It is easier to compute and the required computation burden is much less than the existing two-stage estimation method.Furthermore,the sieve M-estimation is robust in the presence of outliers if we choose appropriate ρ(·).Under some mild conditions,the estimators are shown to be strongly consistent;the convergence rate of the estimator for the unknown nonparametric component is obtained and the estimator for the unknown parameter is shown to be asymptotically normally distributed.Numerical experiments are carried out to investigate the performance of the proposed method.

  14. An EOQ Model for Three parameter Weibull Deteriorating Item with Partial Backlogging

    Directory of Open Access Journals (Sweden)

    L.M. Pradhan

    2013-03-01

    Full Text Available Background: Business organisations are facing a lot of competition during these days. To withstand the competition and to remain in the front row, an enterprise should have optimum profitable plan for his business. Researchers in recent years have developed various inventory models for deteriorating items considering various practical situations. Partial backlogging is considerably a new concept introduced in developing various models for Weibull deteriorating items. Methodology: In this paper an inventory model has been developed considering three parameter Weibull deterioration of a single item with partial backlogging. Here demand rate is considered to be constant and lead time is zero. During the stock out period the backlogging rate is variable and is dependent on the length of the waiting time for the next replenishment. Results and conclusion: Optimal order quantity and total variable cost during a cycle has been derived for the proposed inventory model considering three parameter Weibull deteriorating item with partial backlogging. The results obtained in this paper are illustrated with the help of a numerical example and sensitivity analysis.

  15. Animal models for the study of arterial hypertension

    Indian Academy of Sciences (India)

    Waleska C Dornas; Marcelo E Silva

    2011-09-01

    Hypertension is one of the leading causes of disability or death due to stroke, heart attack and kidney failure. Because the etiology of essential hypertension is not known and may be multifactorial, the use of experimental animal models has provided valuable information regarding many aspects of the disease, which include etiology, pathophysiology, complications and treatment. The models of hypertension are various, and in this review, we provide a brief overview of the most widely used animal models, their features and their importance.

  16. Comparison of annual maximum series and partial duration series methods for modeling extreme hydrologic events

    DEFF Research Database (Denmark)

    Madsen, Henrik; Pearson, Charles P.; Rosbjerg, Dan

    1997-01-01

    Two regional estimation schemes, based on, respectively, partial duration series (PDS) and annual maximum series (AMS), are compared. The PDS model assumes a generalized Pareto (GP) distribution for modeling threshold exceedances corresponding to a generalized extreme value (GEV) distribution...... for annual maxima. First, the accuracy of PDS/GP and AMS/GEV regional index-flood T-year event estimators are compared using Monte Carlo simulations. For estimation in typical regions assuming a realistic degree of heterogeneity, the PDS/GP index-flood model is more efficient. The regional PDS and AMS...

  17. Empirical likelihood confidence regions of the parameters in a partially linear single-index model

    Institute of Scientific and Technical Information of China (English)

    XUE Liugen; ZHU Lixing

    2005-01-01

    In this paper, a partially linear single-index model is investigated, and three empirical log-likelihood ratio statistics for the unknown parameters in the model are suggested. It is proved that the proposed statistics are asymptotically standard chi-square under some suitable conditions, and hence can be used to construct the confidence regions of the parameters. Our methods can also deal with the confidence region construction for the index in the pure single-index model. A simulation study indicates that, in terms of coverage probabilities and average areas of the confidence regions, the proposed methods perform better than the least-squares method.

  18. Efficient Quantile Estimation for Functional-Coefficient Partially Linear Regression Models

    Institute of Scientific and Technical Information of China (English)

    Zhangong ZHOU; Rong JIANG; Weimin QIAN

    2011-01-01

    The quantile estimation methods are proposed for functional-coefficient partially linear regression (FCPLR) model by combining nonparametric and functional-coefficient regression (FCR) model.The local linear scheme and the integrated method are used to obtain local quantile estimators of all unknown functions in the FCPLR model.These resulting estimators are asymptotically normal,but each of them has big variance.To reduce variances of these quantile estimators,the one-step backfitting technique is used to obtain the efficient quantile estimators of all unknown functions,and their asymptotic normalities are derived.Two simulated examples are carried out to illustrate the proposed estimation methodology.

  19. Characteristics of a partially coherent Gaussian Schell-model beam propagating in slanted atmospheric turbulence

    Institute of Scientific and Technical Information of China (English)

    Li Ya-Qing; Wu Zhen-Sen

    2012-01-01

    On the basis of the extended Huygens Fresnel principle and the model of the refractive-index structure constant in the atmospheric turbulence proposed by the International Telecommunication Union-Radio Communication Sector,the characteristics of the partially coherent Gaussian Schell-model(GSM)beams propagating in slanted atmospheric turbulence are studied.Using the cross-spectral density function(CSDF),we derive the expressions for the effective beam radius,the spreading angle,and the average intersity.The variance of the angle-of-arrival fluctuation and the wander effect of the GSM beam in the turbulence are calculated numerically.The influences of the coherence degree,the propagation distance,the propagation height,and the waist radius on the propagation characteristics of the partially coherent beams are discussed and compared with those of the fully coherent Gaussian beams.

  20. Discrete matrix models for partial sums of conformal blocks associated to Painlev\\'e transcendents

    CERN Document Server

    Balogh, F

    2014-01-01

    A recently formulated conjecture of Gamayun, Iorgov and Lisovyy gives an asymptotic expansion of the Jimbo--Miwa--Ueno isomonodromic $\\tau$-function for certain Painlev\\'e transcendents. The coefficients in this expansion are given in terms of conformal blocks of a two-dimensional conformal field theory, which can be written as infinite sums over pairs of partitions. In this note a discrete matrix model is proposed on a lattice whose partition function can be used to obtain a multiple integral representation for the length restricted partial sums of the Painlev\\'e conformal blocks. This leads to expressions of the partial sums involving H\\"ankel determinants associated to the discrete measure of the matrix model, or equivalently, Wronskians of the corresponding moment generating function which is shown to be of the generalized hypergeometric type.

  1. A Selective Moving Window Partial Least Squares Method and Its Application in Process Modeling

    Institute of Scientific and Technical Information of China (English)

    Ouguan Xu; Yongfeng Fu; Hongye Su; Lijuan Li

    2014-01-01

    A selective moving window partial least squares (SMW-PLS) soft sensor was proposed in this paper and applied to a hydro-isomerization process for on-line estimation of para-xylene (PX) content. Aiming at the high frequen-cy of model updating in previous recursive PLS methods, a selective updating strategy was developed. The model adaptation is activated once the prediction error is larger than a preset threshold, or the model is kept unchanged. As a result, the frequency of model updating is reduced greatly, while the change of prediction accuracy is minor. The performance of the proposed model is better as compared with that of other PLS-based model. The compro-mise between prediction accuracy and real-time performance can be obtained by regulating the threshold. The guidelines to determine the model parameters are illustrated. In summary, the proposed SMW-PLS method can deal with the slow time-varying processes effectively.

  2. Console-integrated real-time three-dimensional image overlay navigation for robot-assisted partial nephrectomy with selective arterial clamping: early single-centre experience with 17 cases.

    Science.gov (United States)

    Furukawa, Junya; Miyake, Hideaki; Tanaka, Kazushi; Sugimoto, Maki; Fujisawa, Masato

    2014-12-01

    The objective of this study was to describe our early experience with robot-assisted partial nephrectomy (RAPN) incorporating selective arterial clamping, using an image overlay navigation system. Three-dimensional images were reconstructed from computed tomography using open source processing software, OsiriX, and were directly visualized on the screen of a da Vinci surgeon's console with TilePro multi-input display functions. Using this imaging system, RAPN with selective arterial clamping was performed in 17 patients with renal tumours. The intraoperative image overlay navigation system made it possible to clearly show the tumour position and vascular supply within the console's field of view, and facilitate selective arterial clamping during RAPN, resulting in a mean decrease in estimated glomerular filtration rates at both 1 and 4 weeks after RAPN < 10 ml/min/1.73 m(2) . RAPN with selective arterial clamping using this innovative imaging system could be a useful alternative to conventional RAPN. Copyright © 2014 John Wiley & Sons, Ltd.

  3. From Exact to Partial Dynamical Symmetries: Lessons From the Interacting Boson Model

    CERN Document Server

    Leviatan, A

    2012-01-01

    We exploit the rich algebraic structure of the interacting boson model to explain the notion of partial dynamical symmetry (PDS), and present a procedure for constructing Hamiltonians with this property. We demonstrate the relevance of PDS to various topics in nuclear spectroscopy, including K-band splitting, odd-even staggering in the gamma-band and anharmonicity of excited vibrational bands. Special emphasis in this construction is paid to the role of higher-order terms.

  4. A partial hearing animal model for chronic electro-acoustic stimulation

    Science.gov (United States)

    Irving, S.; Wise, A. K.; Millard, R. E.; Shepherd, R. K.; Fallon, J. B.

    2014-08-01

    Objective. Cochlear implants (CIs) have provided some auditory function to hundreds of thousands of people around the world. Although traditionally carried out only in profoundly deaf patients, the eligibility criteria for implantation have recently been relaxed to include many partially-deaf patients with useful levels of hearing. These patients receive both electrical stimulation from their implant and acoustic stimulation via their residual hearing (electro-acoustic stimulation; EAS) and perform very well. It is unclear how EAS improves speech perception over electrical stimulation alone, and little evidence exists about the nature of the interactions between electric and acoustic stimuli. Furthermore, clinical results suggest that some patients that undergo cochlear implantation lose some, if not all, of their residual hearing, reducing the advantages of EAS over electrical stimulation alone. A reliable animal model with clinically-relevant partial deafness combined with clinical CIs is important to enable these issues to be studied. This paper outlines such a model that has been successfully used in our laboratory. Approach. This paper outlines a battery of techniques used in our laboratory to generate, validate and examine an animal model of partial deafness and chronic CI use. Main results. Ototoxic deafening produced bilaterally symmetrical hearing thresholds in neonatal and adult animals. Electrical activation of the auditory system was confirmed, and all animals were chronically stimulated via adapted clinical CIs. Acoustic compound action potentials (CAPs) were obtained from partially-hearing cochleae, using the CI amplifier. Immunohistochemical analysis allows the effects of deafness and electrical stimulation on cell survival to be studied. Significance. This animal model has applications in EAS research, including investigating the functional interactions between electric and acoustic stimulation, and the development of techniques to maintain residual

  5. TESTING SERIAL CORRELATION IN SEMIPARAMETRIC VARYING COEFFICIENT PARTIALLY LINEAR ERRORS-IN-VARIABLES MODEL

    Institute of Scientific and Technical Information of China (English)

    Xuemei HU; Feng LIU; Zhizhong WANG

    2009-01-01

    The authors propose a V_(N,P) test statistic for testing finite-order serial correlation in a semiparametric varying coefficient partially linear errors-in-variables model. The test statistic is shown to have asymptotic normal distribution under the null hypothesis of no serial correlation. Some Monte Carlo experiments are conducted to examine the finite sample performance of the proposed V_(N,P) test statistic. Simulation results confirm that the proposed test performs satisfactorily in estimated size and power.

  6. Asymptotic Properties in Semiparametric Partially Linear Regression Models for Functional Data

    Institute of Scientific and Technical Information of China (English)

    Tao ZHANG

    2013-01-01

    We consider the semiparametric partially linear regression models with mean function xTβ+g(z),where X and z are functional data.The new estimators of β and g(z) are presented and some asymptotic results are given.The strong convergence rates of the proposed estimators are obtained.In our estimation,the observation number of each subject will be completely flexible.Some simulation study is conducted to investigate the finite sample performance of the proposed estimators.

  7. Effect of beraprost sodium (BPS) in a new rat partial unilateral ureteral obstruction model.

    Science.gov (United States)

    Takenaka, Masahiko; Machida, Noboru; Ida, Nobutaka; Satoh, Nahoko; Kurumatani, Hajimu; Yamane, Yoshihisa

    2009-01-01

    Unilateral ureteral obstruction (UUO) is a representative model for investigating the common mechanism of decreasing renal function in chronic renal failure. In this study, we present a new partial UUO model in adult rats and evaluated the effect of beraprost sodium (BPS: stable prostaglandin I(2) (PGI(2)) analog). We could make reproductive and uniform partial UUO by ligating the left ureter together with a 0.5 mm diameter stainless steel wire with nylon thread, and withdrawing the stainless wire. One week later, the ureteral obstruction was released. After 3 weeks from the release of UUO, all animals of control group, without BPS administration, developed basophilic degeneration of tubular epithelium, tubular dilatation and interstitial fibrosis. The areas of tubular degeneration and fibrosis were significantly reduced in the BPS group, orally administered BPS 300 microg/kg twice a day from the next day of the release of obstruction, than in control group. In conclusion, we can established the adult rat partial UUO-release model and revealed that BPS can inhibit renal tubular damage and tubulointerstitial fibrosis.

  8. Models of magnetized neutron star atmospheres: thin atmospheres and partially ionized hydrogen atmospheres with vacuum polarization

    CERN Document Server

    Suleimanov, V F; Werner, K

    2009-01-01

    Observed X-ray spectra of some isolated magnetized neutron stars display absorption features, sometimes interpreted as ion cyclotron lines. Modeling the observed spectra is necessary to check this hypothesis and to evaluate neutron star parameters.We develop a computer code for modeling magnetized neutron star atmospheres in a wide range of magnetic fields (10^{12} - 10^{15} G) and effective temperatures (3 \\times 10^5 - 10^7 K). Using this code, we study the possibilities to explain the soft X-ray spectra of isolated neutron stars by different atmosphere models. The atmosphere is assumed to consist either of fully ionized electron-ion plasmas or of partially ionized hydrogen. Vacuum resonance and partial mode conversion are taken into account. Any inclination of the magnetic field relative to the stellar surface is allowed. We use modern opacities of fully or partially ionized plasmas in strong magnetic fields and solve the coupled radiative transfer equations for the normal electromagnetic modes in the plas...

  9. A test for Io's magma ocean: Modeling tidal dissipation with a partially molten mantle

    Science.gov (United States)

    Bierson, C. J.; Nimmo, F.

    2016-11-01

    Magnetic induction measurements and astrometry provide constraints on the internal structure of Io, a volcanically active moon of Jupiter. We model the tidal response of a partially molten Io using an Andrade rheology which is supported by silicate deformation experiments. This model uses material properties similar to the Earth's mantle and includes feedbacks between partial melting, tidal heat production, and melt transport. We are able to satisfy constraints provided by the measured imaginary part of the tidal Love number Im(k2), the inferred depth and melt fraction of a near-surface partially molten layer, and the observed equatorial concentration of volcanic landforms. We predict a value for the real part of the tidal Love number of Re(k2) = 0.09 ± 0.02, much smaller than the value of Re(k2)≈0.5 predicted for an Io with a fluid magma ocean. Future spacecraft observations should be able to measure this value and test which model is correct.

  10. A Numerical Multiscale Framework for Modeling Patient-Specific Coronary Artery Bypass Surgeries

    Science.gov (United States)

    Ramachandra, Abhay B.; Kahn, Andrew; Marsden, Alison

    2014-11-01

    Coronary artery bypass graft (CABG) surgery is performed to revascularize diseased coronary arteries, using arterial, venous or synthetic grafts. Vein grafts, used in more than 70% of procedures, have failure rates as high as 50% in less than 10 years. Hemodynamics is known to play a key role in the mechano-biological response of vein grafts, but current non-invasive imaging techniques cannot fully characterize the hemodynamic and biomechanical environment. We numerically compute hemodynamics and wall mechanics in patient-specific 3D CABG geometries using stabilized finite element methods. The 3D patient-specific domain is coupled to a 0D lumped parameter circulatory model and parameters are tuned to match patient-specific blood pressures, stroke volumes, heart rates and heuristic flow-split values. We quantify differences in hemodynamics between arterial and venous grafts and discuss possible correlations to graft failure. Extension to a deformable wall approximation will also be discussed. The quantification of wall mechanics and hemodynamics is a necessary step towards coupling continuum models in solid and fluid mechanics with the cellular and sub-cellular responses of grafts, which in turn, should lead to a more accurate prediction of the long term outcome of CABG surgeries, including predictions of growth and remodeling.

  11. Simulations of Magnetohemodynamics in Stenosed Arteries in Diabetic or Anemic Models

    Science.gov (United States)

    Alshare, Aiman; Tashtoush, Bourhan

    2016-01-01

    Pulsatile flow simulations of non-Newtonian blood flow in an axisymmetric multistenosed artery, subjected to a static magnetic field, are performed using FLUENT. The influence of artery size and magnetic field intensity on transient wall shear stress, mean shear stress, and pressure drop is investigated. Three different types of blood, namely, healthy, diabetic, and anemic are considered. It is found that using Newtonian viscosity model of blood in contrast to Carreau model underestimates the pressure drop and wall shear stress by nearly 34% and 40%, respectively. In addition, it is found that using a magnetic field increases the pressure drop by 15%. Generally, doubling the artery diameter reduces the wall shear stress approximately by 1.6 times. Also increasing the stenosis level from moderate to severe results in reduction of the shear stress by 1.6 times. Furthermore, doubling the diameter of moderately stenosed artery results in nearly 3-fold decrease in pressure drop. It is also found that diabetic blood results in higher shear stress and greater pressure drop in comparison to healthy blood, whereas anemic blood has a decreasing effect on both wall shear stress and pressure drop in comparison to healthy blood. PMID:27057205

  12. Simulations of Magnetohemodynamics in Stenosed Arteries in Diabetic or Anemic Models

    Directory of Open Access Journals (Sweden)

    Aiman Alshare

    2016-01-01

    Full Text Available Pulsatile flow simulations of non-Newtonian blood flow in an axisymmetric multistenosed artery, subjected to a static magnetic field, are performed using FLUENT. The influence of artery size and magnetic field intensity on transient wall shear stress, mean shear stress, and pressure drop is investigated. Three different types of blood, namely, healthy, diabetic, and anemic are considered. It is found that using Newtonian viscosity model of blood in contrast to Carreau model underestimates the pressure drop and wall shear stress by nearly 34% and 40%, respectively. In addition, it is found that using a magnetic field increases the pressure drop by 15%. Generally, doubling the artery diameter reduces the wall shear stress approximately by 1.6 times. Also increasing the stenosis level from moderate to severe results in reduction of the shear stress by 1.6 times. Furthermore, doubling the diameter of moderately stenosed artery results in nearly 3-fold decrease in pressure drop. It is also found that diabetic blood results in higher shear stress and greater pressure drop in comparison to healthy blood, whereas anemic blood has a decreasing effect on both wall shear stress and pressure drop in comparison to healthy blood.

  13. Imaging of Small Animal Peripheral Artery Disease Models: Recent Advancements and Translational Potential

    Directory of Open Access Journals (Sweden)

    Jenny B. Lin

    2015-05-01

    Full Text Available Peripheral artery disease (PAD is a broad disorder encompassing multiple forms of arterial disease outside of the heart. As such, PAD development is a multifactorial process with a variety of manifestations. For example, aneurysms are pathological expansions of an artery that can lead to rupture, while ischemic atherosclerosis reduces blood flow, increasing the risk of claudication, poor wound healing, limb amputation, and stroke. Current PAD treatment is often ineffective or associated with serious risks, largely because these disorders are commonly undiagnosed or misdiagnosed. Active areas of research are focused on detecting and characterizing deleterious arterial changes at early stages using non-invasive imaging strategies, such as ultrasound, as well as emerging technologies like photoacoustic imaging. Earlier disease detection and characterization could improve interventional strategies, leading to better prognosis in PAD patients. While rodents are being used to investigate PAD pathophysiology, imaging of these animal models has been underutilized. This review focuses on structural and molecular information and disease progression revealed by recent imaging efforts of aortic, cerebral, and peripheral vascular disease models in mice, rats, and rabbits. Effective translation to humans involves better understanding of underlying PAD pathophysiology to develop novel therapeutics and apply non-invasive imaging techniques in the clinic.

  14. Comparison of annual maximum series and partial duration series methods for modeling extreme hydrologic events

    DEFF Research Database (Denmark)

    Madsen, Henrik; Rasmussen, Peter F.; Rosbjerg, Dan

    1997-01-01

    Two different models for analyzing extreme hydrologic events, based on, respectively, partial duration series (PDS) and annual maximum series (AMS), are compared. The PDS model assumes a generalized Pareto distribution for modeling threshold exceedances corresponding to a generalized extreme value...... model with ML estimation for large positive shape parameters. Since heavy-tailed distributions, corresponding to negative shape parameters, are far the most common in hydrology, the PDS model generally is to be preferred for at-site quantile estimation....... distribution for annual maxima. The performance of the two models in terms of the uncertainty of the T-year event estimator is evaluated in the cases of estimation with, respectively, the maximum likelihood (ML) method, the method of moments (MOM), and the method of probability weighted moments (PWM...

  15. Region-based geometric modelling of human airways and arterial vessels.

    Science.gov (United States)

    Ding, Songlin; Ye, Yong; Tu, Jiyuan; Subic, Aleksandar

    2010-03-01

    Anatomically precise geometric models of human airways and arterial vessels play a critical role in the analysis of air and blood flows in human bodies. The established geometric modelling methods become invalid when the model consists of bronchioles or small vessels. This paper presents a new method for reconstructing the entire airway tree and carotid vessels from point clouds obtained from CT or MR images. A novel layer-by-layer searching algorithm has been developed to recognize branches of the airway tree and arterial vessels from the point clouds. Instead of applying uniform accuracy to all branches regardless of the number of available points, the surface patches on each branch are constructed adaptively based on the number of available elemental points, which leads to the elimination of distortions occurring at small bronchi and vessels.

  16. Average intensity and spreading of partially coherent model beams propagating in a turbulent biological tissue

    Science.gov (United States)

    Wu, Yuqian; Zhang, Yixin; Wang, Qiu; Hu, Zhengda

    2016-11-01

    For Gaussian beams with three different partially coherent models, including Gaussian-Schell model (GSM), Laguerre-Gaussian Schell-model (LGSM) and Bessel-Gaussian Schell-model (BGSM) beams propagating through a biological turbulent tissue, the expression of the spatial coherence radius of a spherical wave propagating in a turbulent biological tissue, and the average intensity and beam spreading for GSM, LGSM and BGSM beams are derived based on the fractal model of power spectrum of refractive-index variations in biological tissue. Effects of partially coherent model and parameters of biological turbulence on such beams are studied in numerical simulations. Our results reveal that the spreading of GSM beams is smaller than LGSM and BGSM beams on the same conditions, and the beam with larger source coherence width has smaller beam spreading than that with smaller coherence width. The results are useful for any applications involved light beam propagation through tissues, especially the cases where the average intensity and spreading properties of the light should be taken into account to evaluate the system performance and investigations in the structures of biological tissue.

  17. Evaluating how species niche modelling is affected by partial distributions with an empirical case

    Science.gov (United States)

    Carretero, Miguel A.; Sillero, Neftalí

    2016-11-01

    Ecological niche models (ENMs) will successfully identify a species' ecological niche, provided that important assumptions are fulfilled, namely environment equilibrium and niche equality across the distribution. Violations may seriously affect ENM reliability, leading to erroneous biogeographic conclusions and inappropriate conservation prioritisation. We evaluate the robustness of ENMs against incomplete knowledge of distribution with a real example, the threatened Iberian lizard Podarcis carbonelli, whose distribution was gradually discovered over a long time period. We used several ENM methods for presence-only data (Maxent, ENFA, Bioclim, and Domain) to infer the realised ecological niche at two spatial resolutions (1 km and 200 m). The distribution data were split into four partial datasets corresponding to separate subranges: Central System (CS); Viseu-Aveiro (VA); Atlantic coast (AC); and Doñana (DO). We then accumulated the datasets following the species discovery sequence: CS + VA, CS + VA + AC, and CS + VA + AC + DO. Niche equivalence and similarity between partial models were compared using Ecospat. ENMs were strongly affected by the violation of niche equilibrium; only the VA subrange forecasts the complete species range. ENMs were also sensitive to the violation of niche equality: only VA models were similar to the Iberian model, altitude being the most important variable followed by annual precipitation, maximum temperature in July, and annual radiation. When the ENMs were applied only to the first subrange discovered (CS), only the VA area was predicted, while the other subranges might have remained unknown, thus compromising conservation strategies. As assumptions of niche equilibrium and equality were violated, likely owing to the species' ecological multimodality, the models generated were biased and of limited predictive value. ENMs are useful tools in biogeography and conservation, but only if their basal assumptions are achieved. Partial

  18. Arterial hypoxemia and intrapulmonary vasodilatation in rat models of portal hypertension.

    Science.gov (United States)

    Katsuta, Yasumi; Zhang, Xue-Jun; Ohsuga, Masaru; Akimoto, Toshio; Komeichi, Hirokazu; Shimizu, Shuji; Kato, Yoshihito; Miyamoto, Akiko; Satomura, Katsuaki; Takano, Teruo

    2005-08-01

    Rats with chronic bile duct ligation (CBDL) and portal vein ligation (PVL) are used as models of portal hypertension. CBDL rats show hypoxemia with intrapulmonary vasodilatation (IPVD), and are recognized as a model of hepatopulmonary syndrome (HPS), while PVL rats are normoxemic. We investigated the differences in arterial oxygenation between these models, and the key factors leading to HPS. Forty-eight Sprague-Dawley rats were prepared as CBDL or PVL models, or as Sham rats. Arterial oxygenation, hemodynamics (reference sample method), and IPVD were simultaneously evaluated in conscious and unrestrained animals, using (141)Ce- or (113)Sn-labeled microspheres (15 microm in diameter), respectively. Endothelin-1 (ET-1) and nitrate/nitrite (end products of nitric oxide; NOx) production by the lung tissue (increment across the lungs) was also determined. The extent of IPVD was similar in both models, but hypoxemia was only observed in CBDL rats. The ET-1 level and the increment in NOx were significantly increased in CBDL rats, and the increment was directly correlated with impairment of oxygenation. Blood flow through the bronchial arteries (anatomical shunting) was increased in CBDL rats, reaching more than three times the level in PVL rats or Sham rats. These results support the hypothesis that NO derived from the lung tissues contributes to hypoxemia, and IPVD appears to be a prerequisite for impaired oxygenation. The considerable increase of anatomical shunting may potentially contribute to impaired oxygenation in CBDL rats.

  19. A novel arterial pouch model of saccular aneurysm by concomitant elastase and collagenase digestion

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Background: An ideal aneurysm model of cerebral aneurysm is of great importance for studying the pathogenesis of the lesion and testing new techniques for diagnosis and treatment. Several models have been created in rabbits and are now widely used in experimental studies; however, every model has certain intrinsic limitations. Here we report the development of a novel saccular aneurysm model in rabbits using an arterial pouch that is subject to in vitro pre-digestion with combined elastase and collagenase. Methods: A segment of right common carotid artery (CCA) was dissected out and treated with elastase (60 U/ml, 20 min) followed by type I collagenase (1 mg/ml, 15 min) in vitro. The graft was anastomosed to an arterial arch built with the left CCA and the remaining right CCA, while the other end of the graft was ligated. The dimension and tissue structure of the pouch were analysed immediately, 2 or 8 weeks after operation. Findings: Ten terminal aneurysms were produced. The gross morphology of the aneurysm resembles the human cerebral terminal aneurysms. We have observed the following pathological changes:(1) growth of the aneurysm (mean diameter increased from (2.0±0.1) to (3.2±0.3) mm at 2 weeks, P<0.001, n=7~10); (2) thinning of the aneurysmal wall (the mean wall thickness decreased to 44% at 2 weeks), which was accompanied by significant losses of elastic fibres, collagen and the cellular component; and (3) spontaneous rupture (3 out of 9, one aneurysm ruptured 24 h after operation with the other two at 2 and 4 weeks respectively). Conclusion: This rabbit arterial pouch model mimics human cerebral aneurysms in relation to morphology and histology. In particular, this model exhibited an increased tendency of spontaneous rupture.

  20. New methods for computational fluid dynamics modeling of carotid artery from magnetic resonance angiography

    Science.gov (United States)

    Cebral, Juan R.; Yim, Peter J.; Loehner, Rainald; Soto, Orlando; Marcos, Hani; Choyke, Peter L.

    2001-05-01

    Computational fluid dynamics (CFD) models of the carotid artery are constructed from contrast-enhanced magnetic resonance angiography (MRA) using a deformable model and a surface-merging algorithm. Physiologic flow conditions are obtained from cine phase-contrast MRA at two slice locations below and above the carotid bifurcation. The methodology was tested on image data from a rigid flow-through phantom of a carotid artery with 65% degree stenosis. Predicted flow patterns are in good agreement with MR flow measurements at intermediate slice locations. Our results show that flow in a rigid flow-through phantom of the carotid bifurcation with stenosis can be simulated accurately with CFD. The methodology was then tested on flow and anatomical data from a normal human subject. The sum of the instantaneous flows measured at the internal and external carotids differs from that at the common carotid, indicating that wall compliance must be modeled. Coupled fluid-structure calculations were able to reproduce the significant dampening of the velocity waveform observed between different slices along the common carotid artery. Visualizations of the blood flow in a compliant model of the carotid bifurcation were produced. A comparison between compliant and rigid models shows significant differences in the time-dependent wall shear stress at selected locations. Our results confirm that image-based CFD techniques can be applied to the modeling of hemodynamics in compliant carotid arteries. These capabilities may eventually allow physicians to enhance current image-based diagnosis, and to predict and evaluate the outcome of interventional procedures non- invasively.

  1. Model-based process analysis of partial nitrification efficiency under dynamic nitrogen loading.

    Science.gov (United States)

    Güven, Didem; Kutlu, Ozgül; Insel, Güçlü; Sözen, Seval

    2009-08-01

    In this study, the ammonia removal efficiency for high ammonia-containing wastewaters was evaluated via partial nitrification. A nitrifier biocommunity was first enriched in a fill-and-draw batch reactor with a specific ammonium oxidation rate of 0.1 mg NH(4) (-)-N/mg VSS.h. Partial nitrification was established in a chemostat at a hydraulic retention time (HRT) of 1.15 days, which was equal to the sludge retention time (SRT). The results showed that the critical HRT (SRT) was 1.0 day for the system. A maximum specific ammonium oxidation rate was achieved as 0.280 mg NH(4) (-)-N/mg VSS.h, which is 2.8-fold higher than that obtained in the fill-and-draw reactor, indicating that more adaptive and highly active ammonium oxidizers were enriched in the chemostat. Dynamic modeling of partial nitrification showed that the maximum growth rate for ammonium oxidizers was found to be 1.22 day(-1). Modeling studies also validated the recovery period as 10 days.

  2. Portfolio optimization in a defaults model under full/partial information

    CERN Document Server

    Lim, Thomas

    2010-01-01

    In this paper, we consider a financial market with assets exposed to some risks inducing jumps in the asset prices, and which can still be traded after default times. We use a default-intensity modeling approach, and address in this incomplete market context the problem of maximization of expected utility from terminal wealth for logarithmic, power and exponential utility functions. We study this problem as a stochastic control problem both under full and partial information. Our contribution consists in showing that the optimal strategy can be obtained by a direct approach for the logarithmic utility function, and the value function for the power utility function can be determined as the minimal solution of a backward stochastic differential equation. For the partial information case, we show how the problem can be divided into two problems: a filtering problem and an optimization problem. We also study the indifference pricing approach to evaluate the price of a contingent claim in an incomplete market and ...

  3. Partial Overhaul and Initial Parallel Optimization of KINETICS, a Coupled Dynamics and Chemistry Atmosphere Model

    Science.gov (United States)

    Nguyen, Howard; Willacy, Karen; Allen, Mark

    2012-01-01

    KINETICS is a coupled dynamics and chemistry atmosphere model that is data intensive and computationally demanding. The potential performance gain from using a supercomputer motivates the adaptation from a serial version to a parallelized one. Although the initial parallelization had been done, bottlenecks caused by an abundance of communication calls between processors led to an unfavorable drop in performance. Before starting on the parallel optimization process, a partial overhaul was required because a large emphasis was placed on streamlining the code for user convenience and revising the program to accommodate the new supercomputers at Caltech and JPL. After the first round of optimizations, the partial runtime was reduced by a factor of 23; however, performance gains are dependent on the size of the data, the number of processors requested, and the computer used.

  4. Takagi-Sugeno fuzzy modeling and chaos control of partial differential systems.

    Science.gov (United States)

    Vasegh, Nastaran; Khellat, Farhad

    2013-12-01

    In this paper a unified approach is presented for controlling chaos in nonlinear partial differential systems by a fuzzy control design. First almost all known chaotic partial differential equation systems are represented by Takagi-Sugeno fuzzy model. For investigating design procedure, Kuramoto-Sivashinsky (K-S) equation is selected. Then, all linear subsystems of K-S equation are transformed to ordinary differential equation (ODE) systems by truncated Fourier series of sine-cosine functions. By solving Riccati equation for each ODE systems, parallel stabilizing feedback controllers are determined. Finally, a distributed fuzzy feedback for K-S equation is designed. Numerical simulations are given to show that the distributed fuzzy controller is very easy to design, efficient, and capable to extend.

  5. Takagi-Sugeno fuzzy modeling and chaos control of partial differential systems

    Science.gov (United States)

    Vasegh, Nastaran; Khellat, Farhad

    2013-12-01

    In this paper a unified approach is presented for controlling chaos in nonlinear partial differential systems by a fuzzy control design. First almost all known chaotic partial differential equation systems are represented by Takagi-Sugeno fuzzy model. For investigating design procedure, Kuramoto-Sivashinsky (K-S) equation is selected. Then, all linear subsystems of K-S equation are transformed to ordinary differential equation (ODE) systems by truncated Fourier series of sine-cosine functions. By solving Riccati equation for each ODE systems, parallel stabilizing feedback controllers are determined. Finally, a distributed fuzzy feedback for K-S equation is designed. Numerical simulations are given to show that the distributed fuzzy controller is very easy to design, efficient, and capable to extend.

  6. Average intensity and directionality of partially coherent model beams propagating in turbulent ocean.

    Science.gov (United States)

    Wu, Yuqian; Zhang, Yixin; Zhu, Yun

    2016-08-01

    We studied Gaussian beams with three different partially coherent models, including the Gaussian-Schell model (GSM), Laguerre-Gaussian Schell model (LGSM), and Bessel-Gaussian Schell model (BGSM), propagating through oceanic turbulence. The expressions of average intensity, beam spreading, and beam wander for GSM, LGSM, and BGSM beams in the paraxial channel are derived. We make a contrast for the three models in numerical simulations and find that the GSM beam has smaller spreading than the others, and the LGSM beam needs longer propagation distance to transform into a well-like profile of average intensity than the BGSM beam in the same conditions. The salinity fluctuation has a greater contribution to the wander of LGSM and BGSM beams than that of the temperature fluctuation. Our results can be helpful in the design of an optical wireless communication link operating in oceanic environment.

  7. A Leasing Model to Deal with Partial Failures in Mobile Ad Hoc Networks

    Science.gov (United States)

    Gonzalez Boix, Elisa; van Cutsem, Tom; Vallejos, Jorge; de Meuter, Wolfgang; D'Hondt, Theo

    In mobile ad hoc networks (MANETs) many partial failures are the result of temporary network partitions due to the intermittent connectivity of mobile devices. Some of these failures will be permanent and require application-level failure handling. However, it is impossible to distinguish a permanent from a transient failure. Leasing provides a solution to this problem based on the temporal restriction of resources. But to date no leasing model has been designed specifically for MANETs. In this paper, we identify three characteristics required for a leasing model to be usable in a MANET, discuss the issues with existing leasing models and then propose the leased object references model, which integrates leasing with remote object references. In addition, we describe an implementation of the model in the programming language AmbientTalk. Leased object references provide an extensible framework that allows programmers to express their own leasing patterns and enables both lease holders (clients) and lease grantors (services) to deal with permanent failures.

  8. Prediction of Coal Consumption in China Based on the Partial Linear Model

    Institute of Scientific and Technical Information of China (English)

    Ying; XIE; Chunxiang; ZHAO

    2015-01-01

    China is one of the few countries using coal as the main energy and is the world’s second largest coal consumer. Researching the coal consumption is very necessary. At present,the prediction model of coal consumption is mainly based on time series analysis of price,and it rarely considers the influence of other factors. In this paper,on the basis of demand theory,we establish the multiple impact indicators,and use principal component analysis as well as partial linear model for multiple factors to establish coal consumption model. By using this model to forecast the coal consumption in 2011,we find that the predicted value is close to actual value,which means that the model is good.

  9. Extent of partial ice cover due to carbon cycle feedback in a zonal energy balance model

    Directory of Open Access Journals (Sweden)

    C. Huntingford

    2003-01-01

    Full Text Available A global carbon cycle is introduced into a zonally averaged energy balance climate model. The physical model components are similar to those of Budyko (1969 and Sellers (1969. The new carbon components account for atmospheric carbon dioxide concentrations and the terrestrial and oceanic storage of carbon. Prescribing values for the sum of these carbon components, it is found that inclusion of a closed carbon cycle reduces the range of insolation over which stable partial ice cover solutions may occur. This highly simplified climate model also predicts that the estimated release of carbon from fossil fuel burning over the next hundred years could result in the eventual melting of the ice sheets. Keywords: climate, carbon cycle,zonal model, earth system modelling

  10. LES-Modeling of a Partially Premixed Flame using a Deconvolution Turbulence Closure

    Science.gov (United States)

    Wang, Qing; Wu, Hao; Ihme, Matthias

    2015-11-01

    The modeling of the turbulence/chemistry interaction in partially premixed and multi-stream combustion remains an outstanding issue. By extending a recently developed constrained minimum mean-square error deconvolution (CMMSED) method, to objective of this work is to develop a source-term closure for turbulent multi-stream combustion. In this method, the chemical source term is obtained from a three-stream flamelet model, and CMMSED is used as closure model, thereby eliminating the need for presumed PDF-modeling. The model is applied to LES of a piloted turbulent jet flame with inhomogeneous inlets, and simulation results are compared with experiments. Comparisons with presumed PDF-methods are performed, and issues regarding resolution and conservation of the CMMSED method are examined. The author would like to acknowledge the support of funding from Stanford Graduate Fellowship.

  11. Experimental intra-arterial administration of SR-2508 in the rabbit V2 carcinoma model

    Energy Technology Data Exchange (ETDEWEB)

    Coldwell, D.M.; Huff, J.; Marcellus, H.; Coldwell, S.G.

    1989-03-01

    The use of the nitroimidazole radiation sensitizers, misonidazole and SR-2508, has been limited by a variety of side-effects, principally peripheral neuropathies. To increase the effectiveness of radiosensitization and reduce the administered dose of the sensitizers, intra-arterial delivery of SR-2508 was performed and followed with 10Gy of 4 MeV photon beam radiotherapy in the rabbit V2 carcinoma tumour model. Comparison was made with rabbits treated with an identical dose of SR-2508 given intravenously prior to photon beam radiotherapy. Control animals were treated with radiation therapy only, intra-arterial SR-2508 only, or had no treatment. Neither radiation therapy alone nor SR-2508 alone had any effect on tumour growth. In the intra-arterial group, tumour growth was slower and size was significantly smaller than all other groups. Results suggest that the intra-arterial infusion of radiation sensitizer produces greater tumour response than intravenous infusion when each is combined with radiation therapy.

  12. Splenic artery embolization with Ankaferd blood stopper in a sheep model

    Science.gov (United States)

    Koç, Osman; Acar, Kadir; Özbek, Orhan; Güler, İbrahim; Sarıtaş, Kadir; Erdem, Tuba Bera; Solak, Yalçın; Toy, Hatice; Küçükapan, Ahmet; Özbek, Seda; Gaipov, Abduzhappar; Haznedaroğlu, İbrahim C.

    2016-01-01

    PURPOSE Splenic artery embolization is a minimally invasive therapeutic procedure utilized in a number of disorders. Ankaferd blood stopper (ABS) is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We aimed to investigate the safety and efficiency of ABS for splenic artery embolization in a sheep model. METHODS Seven adult female sheep were included in the study. Selective celiac angiography was performed using a 5F diagnostic catheter and then a 2.7F hydrophilic coating microcatheter was advanced coaxially to the distal part of the main splenic artery. Under fluoroscopic guidance, 6 mL mixture composed of half-and-half ABS and contrast agent was slowly injected. Fluoroscopy was used to observe the deceleration and stagnation of the flow. Control celiac angiograms were obtained immediately after the embolization. After the procedure, the animals were observed for one day and then sacrificed with intravenous sodium thiopental. RESULTS Technical success rate was 100%. None of the animals died or experienced a major systemic adverse event during the procedure. All of the spleens appeared dark on macroscopic examination due to excessive thrombosis. Microscopically, the majority of the splenic sinusoids (90%–95%) were necrotic. CONCLUSION In our study, splenic artery embolization by ABS was found to be safe and effective in the shortterm. Further studies are needed to better understand the embolizing potential of this novel hemostatic agent. PMID:27306661

  13. Turbulence detection in a stenosed artery bifurcation by numerical simulation of pulsatile blood flow using the low-Reynolds number turbulence model.

    Science.gov (United States)

    Ghalichi, Farzan; Deng, Xiaoyan

    2003-01-01

    The pulsatile blood flow in a partially blocked artery is significantly altered as the flow regime changes through the cardiac cycle. This paper reports on the application of a low-Reynolds turbulence model for computation of physiological pulsatile flow in a healthy and stenosed carotid artery bifurcation. The human carotid artery was chosen since it has received much attention because atherosclerotic lesions are frequently observed. The Wilcox low-Re k-omega turbulence model was used for the simulation since it has proven to be more accurate in describing transition from laminar to turbulent flow. Using the FIDAP finite element code a validation showed very good agreement between experimental and numerical results for a steady laminar to turbulent flow transition as reported in a previous publication by the same authors. Since no experimental or numerical results were available in the literature for a pulsatile and turbulent flow regime, a comparison between laminar and low-Re turbulent calculations was made to further validate the turbulence model. The results of this study showed a very good agreement for velocity profiles and wall shear stress values for this imposed pulsatile laminar flow regime. To explore further the medical aspect, the calculations showed that even in a healthy or non-stenosed artery, small instabilities could be found at least for a portion of the pulse cycle and in different sections. The 40% and 55% diameter reduction stenoses did not significantly change the turbulence characteristics. Further results showed that the presence of 75% stenoses changed the flow properties from laminar to turbulent flow for a good portion of the cardiac pulse. A full 3D simulation with this low-Re-turbulence model, coupled with Doppler ultrasound, can play a significant role in assessing the degree of stenosis for cardiac patients with mild conditions.

  14. PREDICTION OF BLOOD PATTERN IN S-SHAPED MODEL OF ARTERY UNDER NORMAL BLOOD PRESSURE

    Directory of Open Access Journals (Sweden)

    Mohd Azrul Hisham Mohd Adib

    2013-06-01

    Full Text Available Athletes are susceptible to a wide variety of traumatic and non-traumatic vascular injuries to the lower limb. This paper aims to predict the three-dimensional flow pattern of blood through an S-shaped geometrical artery model. This model has created by using Fluid Structure Interaction (FSI software. The modeling of the geometrical S-shaped artery is suitable for understanding the pattern of blood flow under constant normal blood pressure. In this study, a numerical method is used that works on the assumption that the blood is incompressible and Newtonian; thus, a laminar type of flow can be considered. The authors have compared the results with a previous study with FSI validation simulation. The validation and verification of the simulation studies is performed by comparing the maximum velocity at t = 0.4 s, because at this time, the blood accelerates rapidly. In addition, the resulting blood flow at various times, under the same boundary conditions in the S-shaped geometrical artery model, is presented. The graph shows that velocity increases linearly with time. Thus, it can be concluded that the flow of blood increases with respect to the pressure inside the body.

  15. Reconstruction of coronary artery centrelines from x-ray rotational angiography using a probabilistic mixture model

    Science.gov (United States)

    Ćimen, Serkan; Gooya, Ali; Frangi, Alejandro F.

    2016-03-01

    Three-dimensional reconstructions of coronary arterial trees from X-ray rotational angiography (RA) images have the potential to compensate the limitations of RA due to projective imaging. Most of the existing model based reconstruction algorithms are either based on forward-projection of a 3D deformable model onto X-ray angiography images or back-projection of 2D information extracted from X-ray angiography images to 3D space for further processing. All of these methods have their shortcomings such as dependency on accurate 2D centerline segmentations. In this paper, the reconstruction is approached from a novel perspective, and is formulated as a probabilistic reconstruction method based on mixture model (MM) representation of point sets describing the coronary arteries. Specifically, it is assumed that the coronary arteries could be represented by a set of 3D points, whose spatial locations denote the Gaussian components in the MM. Additionally, an extra uniform distribution is incorporated in the mixture model to accommodate outliers (noise, over-segmentation etc.) in the 2D centerline segmentations. Treating the given 2D centreline segmentations as data points generated from MM, the 3D means, isotropic variance, and mixture weights of the Gaussian components are estimated by maximizing a likelihood function. Initial results from a phantom study show that the proposed method is able to handle outliers in 2D centreline segmentations, which indicates the potential of our formulation. Preliminary reconstruction results in the clinical data are also presented.

  16. In vitro model of atherosclerosis using coculture of arterial wall cells and macrophage.

    Science.gov (United States)

    Wada, Y; Sugiyama, A; Kohro, T; Kobayashi, M; Takeya, M; Naito, M; Kodama, T

    2000-12-01

    In order to determine the precise mechanism of the interactions between different types of cells, which are common phenomena in tissues and organs, the importance of coculture techniques are becoming increasingly important. In the area of cardiology, artificial arteries have been developed, based on the understanding of physiological communication of the arterial smooth muscle cells (SMC), endothelial cells (EC), and the extracellular matrix (ECM). In the study of atherosclerosis, the modification of low-density lipoprotein (LDL), which result in the recruitment and accumulation of white blood cells, especially, monocytes/macrophages, and foam cell formation, are hypothesized. Although there are well known animal models, an in vitro model of atherogenesis with a precisely known atherogenesis mechanism has not yet been developed. In this paper, an arterial wall reconstruction model using rabbit primary cultivated aortic SMCs and ECs, was shown. In addition, human peripheral monocytes were used and the transmigration of monocytes was observed by scanning electron and laser confocal microscopy. Monocyte differentiation into macrophages was shown by immunohistochemistry and comprehensive gene expression analysis. With the modified form of LDL, the macrophages were observed to accumulate lipids with a foamy appearance and differentiate into the foam cells in the ECM between the ECs and SMCs in the area of our coculture model.

  17. Prediction of coronary plaque location on arteries having myocardial bridge, using finite element models.

    Science.gov (United States)

    Nikolić, Dalibor; Radović, Miloš; Aleksandrić, Srđan; Tomašević, Miloje; Filipović, Nenad

    2014-11-01

    This study was performed to evaluate the influences of the myocardial bridges on the plaque initializations and progression in the coronary arteries. The wall structure is changed due to the plaque presence, which could be the reason for multiple heart malfunctions. Using simplified parametric finite element model (FE model) of the coronary artery having myocardial bridge and analyzing different mechanical parameters from blood circulation through the artery (wall shear stress, oscillatory shear index, residence time), we investigated the prediction of "the best" position for plaque progression. We chose six patients from the angiography records and used data from DICOM images to generate FE models with our software tools for FE preprocessing, solving and post-processing. We found a good correlation between real positions of the plaque and the ones that we predicted to develop at the proximal part of the myocardial bridges with wall shear stress, oscillatory shear index and residence time. This computer model could be additional predictive tool for everyday clinical examination of the patient with myocardial bridge.

  18. Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness

    Science.gov (United States)

    Halabi, Carmen M.; Broekelmann, Thomas J.; Knutsen, Russell H.; Ye, Li; Mecham, Robert P.

    2015-01-01

    Increased arterial stiffness is a common characteristic of humans with Williams-Beuren syndrome and mouse models of elastin insufficiency. Arterial stiffness is associated with multiple negative cardiovascular outcomes, including myocardial infarction, stroke, and sudden death. Therefore, identifying therapeutic interventions that improve arterial stiffness in response to changes in elastin levels is of vital importance. The goal of this study was to determine the effect of chronic pharmacologic therapy with different classes of antihypertensive medications on arterial stiffness in elastin insufficiency. Elastin-insufficient mice 4–6 wk of age and wild-type littermates were subcutaneously implanted with osmotic micropumps delivering a continuous dose of one of the following: vehicle, losartan, nicardipine, or propranolol for 8 wk. At the end of treatment period, arterial blood pressure and large artery compliance and remodeling were assessed. Our results show that losartan and nicardipine treatment lowered blood pressure and pulse pressure in elastin-insufficient mice. Elastin and collagen content of abdominal aortas as well as ascending aorta and carotid artery biomechanics were not affected by any of the drug treatments in either genotype. By reducing pulse pressure and shifting the working pressure range of an artery to a more compliant region of the pressure-diameter curve, antihypertensive medications may mitigate the consequences of arterial stiffness, an effect that is drug class independent. These data emphasize the importance of early recognition and long-term management of hypertension in Williams-Beuren syndrome and elastin insufficiency. PMID:26232234

  19. Arterial pulse pressure amplification described by means of a nonlinear wave model: characterization of human aging

    Science.gov (United States)

    Alfonso, M.; Cymberknop, L.; Armentano, R.; Pessana, F.; Wray, S.; Legnani, W.

    2016-04-01

    The representation of blood pressure pulse as a combination of solitons captures many of the phenomena observed during its propagation along the systemic circulation. The aim of this work is to analyze the applicability of a compartmental model for propagation regarding the pressure pulse amplification associated with arterial aging. The model was applied to blood pressure waveforms that were synthesized using solitons, and then validated by waveforms obtained from individuals from differentiated age groups. Morphological changes were verified in the blood pressure waveform as a consequence of the aging process (i.e. due to the increase in arterial stiffness). These changes are the result of both a nonlinear interaction and the phenomena present in the propagation of nonlinear mechanic waves.

  20. A Hybrid Windkessel Model of Blood Flow in Arterial Tree Using Velocity Profile Method

    Science.gov (United States)

    Aboelkassem, Yasser; Virag, Zdravko

    2016-11-01

    For the study of pulsatile blood flow in the arterial system, we derived a coupled Windkessel-Womersley mathematical model. Initially, a 6-elements Windkessel model is proposed to describe the hemodynamics transport in terms of constant resistance, inductance and capacitance. This model can be seen as a two compartment model, in which the compartments are connected by a rigid pipe, modeled by one inductor and resistor. The first viscoelastic compartment models proximal part of the aorta, the second elastic compartment represents the rest of the arterial tree and aorta can be seen as the connection pipe. Although the proposed 6-elements lumped model was able to accurately reconstruct the aortic pressure, it can't be used to predict the axial velocity distribution in the aorta and the wall shear stress and consequently, proper time varying pressure drop. We then modified this lumped model by replacing the connection pipe circuit elements with a vessel having a radius R and a length L. The pulsatile flow motions in the vessel are resolved instantaneously along with the Windkessel like model enable not only accurate prediction of the aortic pressure but also wall shear stress and frictional pressure drop. The proposed hybrid model has been validated using several in-vivo aortic pressure and flow rate data acquired from different species such as, humans, dogs and pigs. The method accurately predicts the time variation of wall shear stress and frictional pressure drop. Institute for Computational Medicine, Dept. Biomedical Engineering.

  1. EOQ Models for Deteriorating Items with Time-varying Demand and Partial Backorder under Inflation

    Institute of Scientific and Technical Information of China (English)

    ShanlinYang; YongwuZhou

    2004-01-01

    This paper, through the discounted cash flow (DCF) approach, considers inventory replenishment problems for deteriorating items with general time-varying demand over a finite planning horizon under inflation. The optimal replenishment policies for the total profit of system to be maximum are presented with partial backlogging. Moreover, the fraction of demand backlogged is assumed to be a non-increasing function of waiting time. Firstly, the models with a fixed fraction backorder and complete backorder are provided. Then the model is presented with assuming that the fraction of demand backlogged is an exponentially decreasing function of waiting time. The solution procedures of models are proposed. The effect of inflation on the optimal policies is shown. The models are illustrated through numerical examples and sensitivity analysis of parameters is given.

  2. A Partial Backlogging Inventory Model with Time-Varying Demand During Shortage Period

    Directory of Open Access Journals (Sweden)

    Chen Mang

    2010-11-01

    Full Text Available Harris’s classic square root economic order quantity (EOQ model forms the basis for many other models that relax one or more of its assumptions. A key assumption of the basic EOQ model is that stockouts are not permitted. Due to the excess demands, stock-out situations may arise occasionally. Sometimes, shortages are permitted and they are backordered and satisfied in the very next replenishment. Therefore the objective of this paper is to develop a partial backlogging inventory model, and proposes a new algorithm to minimize the total cost, at the same time also propose the prediction method and algorithm of ordering period. Finally, a practical example of the numerical analysis is given.

  3. NEW EFFICIENT ESTIMATION AND VARIABLE SELECTION METHODS FOR SEMIPARAMETRIC VARYING-COEFFICIENT PARTIALLY LINEAR MODELS.

    Science.gov (United States)

    Kai, Bo; Li, Runze; Zou, Hui

    2011-02-01

    The complexity of semiparametric models poses new challenges to statistical inference and model selection that frequently arise from real applications. In this work, we propose new estimation and variable selection procedures for the semiparametric varying-coefficient partially linear model. We first study quantile regression estimates for the nonparametric varying-coefficient functions and the parametric regression coefficients. To achieve nice efficiency properties, we further develop a semiparametric composite quantile regression procedure. We establish the asymptotic normality of proposed estimators for both the parametric and nonparametric parts and show that the estimators achieve the best convergence rate. Moreover, we show that the proposed method is much more efficient than the least-squares-based method for many non-normal errors and that it only loses a small amount of efficiency for normal errors. In addition, it is shown that the loss in efficiency is at most 11.1% for estimating varying coefficient functions and is no greater than 13.6% for estimating parametric components. To achieve sparsity with high-dimensional covariates, we propose adaptive penalization methods for variable selection in the semiparametric varying-coefficient partially linear model and prove that the methods possess the oracle property. Extensive Monte Carlo simulation studies are conducted to examine the finite-sample performance of the proposed procedures. Finally, we apply the new methods to analyze the plasma beta-carotene level data.

  4. Rasch-Master's Partial Credit Model in the assessment of children's creativity in drawings.

    Science.gov (United States)

    Nakano, Tatiana de Cássia; Primi, Ricardo

    2014-01-01

    The purpose of the present study was to use the Partial Credit Model to study the factors of the Test of Creativity in Children and identify which characteristics of the creative person would be more effective to differentiate subjects according to their ability level. A sample of 1426 students from first to eighth grades answered the instrument. The Partial Credits model was used to estimate the ability of the subjects and item difficulties on a common scale for each of the four factors, indicating which items required a higher level of creativity to be scored and will differentiate the more creative individuals. The results demonstrated that the greater part of the characteristics showed good fit indices, with values between 0.80 and 1.30 both infit and outfit, indicating a response pattern consistent with the model. The characteristics of Unusual Perspective, Expression of Emotion and Originality have been identified as better predictors of creative performance because requires greater ability level (usually above two standard deviation). These results may be used in the future development of an instrument's reduced form or simplification of the current correction model.

  5. Analysis of a Model for the Morphological Structure of Renal Arterial Tree: Fractal Structure

    Directory of Open Access Journals (Sweden)

    Aurora Espinoza-Valdez

    2013-01-01

    experimental data measurements of the rat kidneys. The fractal dimension depends on the probability of sprouting angiogenesis in the development of the arterial vascular tree of the kidney, that is, of the distribution of blood vessels in the morphology generated by the analytical model. The fractal dimension might determine whether a suitable renal vascular structure is capable of performing physiological functions under appropriate conditions. The analysis can describe the complex structures of the development vasculature in kidney.

  6. Arterial remodeling in response to hypertension using a constituent-based model.

    Science.gov (United States)

    Tsamis, Alkiviadis; Stergiopulos, Nikos

    2007-11-01

    Hypertension-induced arterial remodeling has been previously modeled using stress-driven remodeling rate equations in terms of global geometrical adaptation (Rachev A, Stergiopulos N, Meister JJ. Theoretical study of dynamics of arterial wall remodeling in response to changes in blood pressure. J Biomech 29: 635-642, 1996) and was extended later to include adaptation of material properties (Rachev A, Stergiopulos N, Meister JJ. A model for geometric and mechanical adaptation of arteries to sustained hypertension. J Biomech Eng 120: 9-17, 1998). These models, however, used a phenomenological strain energy function (SEF), the parameters of which do not bear a clear physiological meaning. Here, we extend the work of Rachev et al. (1998) by applying similar remodeling rate equations to a constituent-based SEF. The new SEF includes a statistical description for collagen engagement, and remodeling now affects material properties only through changes in the collagen engagement probability density function. The model predicts asymptotic wall thickening and unchanged deformed inner radius as to conserve hoop stress and intimal shear stress, respectively, at the final adapted hypertensive state. Mechanical adaptation serves to restore arterial compliance to control levels. Average circumferential stress-strain curves show that the material at the final adapted hypertensive state is softer than its normotensive counterpart. These findings as well as the predicted pressure-diameter curves are in good qualitative agreement with experimental data. The novelty in our findings is that biomechanical adaptation leading to maintenance of compliance at the hypertensive state can be perfectly achieved by appropriate readjustment of the collagen engagement profile alone.

  7. Effect of partial liquid ventilation on lung function in oleic acid-induced lung injury model of piglets

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ji-zhuo; LI Ling-ke; ZHANG Yan-bo; LI Gang; XU Yu-lin; ZHU Yao-bin

    2013-01-01

    Background Pediatric patients are susceptible to lung injury that does not respond to traditional therapies.Partial liquid ventilation (PLV) has been developed as an alternative ventilatory strategy for treating severe lung injury.The aim of this study is to investigate the effect of PLV on lung function in immature piglets.Methods Acute lung injury was induced in 12 Chinese immature piglets by oleic acid (OA).The animals were randomly assigned to two groups (n=6 each group):(1) conventional mechanical ventilation (MV) group and (2) PLV with FC-77 (10 ml/kg) group.Mean arterial blood pressure (MAP),mean pulmonary arterial pressure (MPAP),central venous pressure (CVP),left atrial pressure (LAP),systemic vascular resistance (SVR),pulmonary vascular resistance (PVR),cardiac output (CO),mean pressure of airway (Paw),dynamic lung compliance (Cydn),and arterial blood gases were measured during the observation period.Results No piglet died in either group with severe lung injury.After four hours of ventilation,pH in the MV group gradually decreased to lower than 7.20,while in the PLV group,pH also gradually decreased but remained higher than 7.20 (P <0.05).Partial pressure of oxygen in artery (PaO2) decreased in both groups,but with a significant difference between the PLV group and MV group (P <0.05).Partial pressure of carbon dioxide in artery (PaCO2) increased in both groups,but with a significant difference between the PLV group and MV group (P <0.05).Paw increased in both groups,but was not significantly different (P >0.05).Cydn decreased in both groups,but without a significant difference (P >0.05).At four hours,heart rate (HR) and MAP in both groups decreased.MPAP in both groups increased,and there was a significant difference between the two groups (P <0.05).CVP was stable in both groups.At four hours,PVR and LAP were increased in both groups.CO was decreased in both groups (P <0.05).SVR was stable during the observation time.Conclusion PLV did not

  8. Fractional modeling of viscoelasticity in 3D cerebral arteries and aneurysms

    Science.gov (United States)

    Yu, Yue; Perdikaris, Paris; Karniadakis, George Em

    2016-10-01

    We develop efficient numerical methods for fractional order PDEs, and employ them to investigate viscoelastic constitutive laws for arterial wall mechanics. Recent simulations using one-dimensional models [1] have indicated that fractional order models may offer a more powerful alternative for modeling the arterial wall response, exhibiting reduced sensitivity to parametric uncertainties compared with the integer-calculus-based models. Here, we study three-dimensional (3D) fractional PDEs that naturally model the continuous relaxation properties of soft tissue, and for the first time employ them to simulate flow structure interactions for patient-specific brain aneurysms. To deal with the high memory requirements and in order to accelerate the numerical evaluation of hereditary integrals, we employ a fast convolution method [2] that reduces the memory cost to O (log ⁡ (N)) and the computational complexity to O (Nlog ⁡ (N)). Furthermore, we combine the fast convolution with high-order backward differentiation to achieve third-order time integration accuracy. We confirm that in 3D viscoelastic simulations, the integer order models strongly depends on the relaxation parameters, while the fractional order models are less sensitive. As an application to long-time simulations in complex geometries, we also apply the method to modeling fluid-structure interaction of a 3D patient-specific compliant cerebral artery with an aneurysm. Taken together, our findings demonstrate that fractional calculus can be employed effectively in modeling complex behavior of materials in realistic 3D time-dependent problems if properly designed efficient algorithms are employed to overcome the extra memory requirements and computational complexity associated with the non-local character of fractional derivatives.

  9. Modeling of a PEM Fuel Cell Stack using Partial Least Squares and Artificial Neural Networks

    Energy Technology Data Exchange (ETDEWEB)

    Han, In-Su; Shin, Hyun Khil [GS Caltex Corp, Daejeon (Korea, Republic of)

    2015-04-15

    We present two data-driven modeling methods, partial least square (PLS) and artificial neural network (ANN), to predict the major operating and performance variables of a polymer electrolyte membrane (PEM) fuel cell stack. PLS and ANN models were constructed using the experimental data obtained from the testing of a 30 kW-class PEM fuel cell stack, and then were compared with each other in terms of their prediction and computational performances. To reduce the complexity of the models, we combined a variables importance on PLS projection (VIP) as a variable selection method into the modeling procedure in which the predictor variables are selected from a set of input operation variables. The modeling results showed that the ANN models outperformed the PLS models in predicting the average cell voltage and cathode outlet temperature of the fuel cell stack. However, the PLS models also offered satisfactory prediction performances although they can only capture linear correlations between the predictor and output variables. Depending on the degree of modeling accuracy and speed, both ANN and PLS models can be employed for performance predictions, offline and online optimizations, controls, and fault diagnoses in the field of PEM fuel cell designs and operations.

  10. Assessment Of Coronary Artery Aneurysms Using Transluminal Attenuation Gradient And Computational Modeling In Kawasaki Disease Patients

    Science.gov (United States)

    Grande Gutierrez, Noelia; Kahn, Andrew; Shirinsky, Olga; Gagarina, Nina; Lyskina, Galina; Fukazawa, Ryuji; Owaga, Shunichi; Burns, Jane; Marsden, Alison

    2015-11-01

    Kawasaki Disease (KD) can result in coronary artery aneurysms (CAA) in up to 25% of patients, putting them at risk of thrombus formation, myocardial infarction and sudden death. Clinical guidelines recommend CAA diameter >8 mm as the arbitrary criterion for initiating systemic anticoagulation. KD patient specific modeling and flow simulations suggest that hemodynamic data can predict regions at increased risk of thrombosis. Transluminal Attenuation Gradient (TAG) is determined from the change in radiological attenuation per vessel length and has been proposed as a non-invasive method for characterizing coronary stenosis from CT Angiography. We hypothesized that CAA abnormal flow could be quantified using TAG. We computed hemodynamics for patient specific coronary models using a stabilized finite element method, coupled numerically to a lumped parameter network to model the heart and vascular boundary conditions. TAG was quantified in the major coronary arteries. We compared TAG for aneurysmal and normal arteries and we analyzed TAG correlation with hemodynamic and geometrical parameters. Our results suggest that TAG may provide hemodynamic data not available from anatomy alone. TAG represents a possible extension to standard CTA that could help to better evaluate the risk of thrombus formation in KD.

  11. Experimental investigations of the steady flow through an idealized model of a femoral artery bypass

    Directory of Open Access Journals (Sweden)

    Giurgea Corina

    2014-03-01

    Full Text Available The present paper presents the steps taken by the authors in the first stage of an experimental program within a larger national research project whose objective is to characterize the flow through a femoral artery bypass with a view to finding solutions for its optimization. The objective of the stage is to investigate by means of the PIV method the stationary flow through a bypass model with an idealized geometry. A bypass assembly which reunites the idealized geometry models of the proximal and distal anastomoses, and which respects the lengths of a femoral artery bypass was constructed on the basis of data for a real patient provided by medical investigations. With the aim of testing the model and the established experimental set-up with regard to their suitability for the assessment of the velocity field associated to the steady flow through the bypass, three zones that can restore the whole distal anastomosis were PIV investigated. The measurements were taken in the conditions of maintained inflow at the bypass entry of 0.9 l / min (Re = 600. The article presents comparatively the flow spectra and the velocity fields for each zone obtained in two situations: with the femoral artery completely occluded and completely open.

  12. A Theoretical Investigation of the Relationship between Structural Equation Modeling and Partial Correlation in Functional MRI Effective Connectivity

    Directory of Open Access Journals (Sweden)

    Guillaume Marrelec

    2009-01-01

    evidence. In this paper, we provide theoretical fundaments explaining why and in what measure structural equation modeling and partial correlations are related. This gives better insight regarding what parts of SEM can be retrieved by partial correlation analysis and what remains inaccessible. We illustrate the different results with real data.

  13. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.

    Science.gov (United States)

    MacRitchie, Neil; Volpert, Giora; Al Washih, Mohammed; Watson, David G; Futerman, Anthony H; Kennedy, Simon; Pyne, Susan; Pyne, Nigel J

    2016-08-01

    Recent studies have demonstrated that the expression of sphingosine kinase 1, the enzyme that catalyses formation of the bioactive lipid, sphingosine 1-phosphate, is increased in lungs from patients with pulmonary arterial hypertension. In addition, Sk1(-/-) mice are protected from hypoxic-induced pulmonary arterial hypertension. Therefore, we assessed the effect of the sphingosine kinase 1 selective inhibitor, PF-543 and a sphingosine kinase 1/ceramide synthase inhibitor, RB-005 on pulmonary and cardiac remodelling in a mouse hypoxic model of pulmonary arterial hypertension. Administration of the potent sphingosine kinase 1 inhibitor, PF-543 in a mouse hypoxic model of pulmonary hypertension had no effect on vascular remodelling but reduced right ventricular hypertrophy. The latter was associated with a significant reduction in cardiomyocyte death. The protection involves a reduction in the expression of p53 (that promotes cardiomyocyte death) and an increase in the expression of anti-oxidant nuclear factor (erythroid-derived 2)-like 2 (Nrf-2). In contrast, RB-005 lacked effects on right ventricular hypertrophy, suggesting that sphingosine kinase 1 inhibition might be nullified by concurrent inhibition of ceramide synthase. Therefore, our findings with PF-543 suggest an important role for sphingosine kinase 1 in the development of hypertrophy in pulmonary arterial hypertension.

  14. Establishment of a hepatic cirrhosis and portal hypertension model by hepatic arterial perfusion with 80% alcohol.

    Science.gov (United States)

    Wang, Lei; He, Fu-Liang; Liu, Fu-Quan; Yue, Zhen-Dong; Zhao, Hong-Wei

    2015-08-28

    To determine the feasibility and safety of establishing a porcine hepatic cirrhosis and portal hypertension model by hepatic arterial perfusion with 80% alcohol. Twenty-one healthy Guizhou miniature pigs were randomly divided into three experimental groups and three control groups. The pigs in the three experimental groups were subjected to hepatic arterial perfusion with 7, 12 and 17 mL of 80% alcohol, respectively, while those in the three control groups underwent hepatic arterial perfusion with 7, 12 and 17 mL of saline, respectively. Hepatic arteriography and direct portal phlebography were performed on all animals before and after perfusion, and the portal venous pressure and diameter were measured before perfusion, immediately after perfusion, and at 2, 4 and 6 wk after perfusion. The following procedures were performed at different time points: routine blood sampling, blood biochemistry, blood coagulation and blood ammonia tests before surgery, and at 2, 4 and 6 wk after surgery; hepatic biopsy before surgery, within 6 h after surgery, and at 1, 2, 3, 4 and 5 wk after surgery; abdominal enhanced computed tomography examination before surgery and at 6 wk after surgery; autopsy and multi-point sampling of various liver lobes for histological examination at 6 wk after surgery. In experimental group 1, different degrees of hepatic fibrosis were observed, and one pig developed hepatic cirrhosis. In experimental group 2, there were cases of hepatic cirrhosis, different degrees of increased portal venous pressure, and intrahepatic portal venous bypass, but neither extrahepatic portal-systemic bypass circulation nor death occurred. In experimental group 3, two animals died and three animals developed hepatic cirrhosis, and different degrees of increased portal venous pressure and intrahepatic portal venous bypass were also observed, but there was no extrahepatic portal-systemic bypass circulation. It is feasible to establish an animal model of hepatic cirrhosis and

  15. Screening for a Chronic Disease: A Multiple Stage Duration Model with Partial Observability.

    Science.gov (United States)

    Mroz, Thomas A; Picone, Gabriel; Sloan, Frank; Yashkin, Arseniy P

    2016-08-01

    We estimate a dynamic multi-stage duration model to investigate how early detection of diabetes can delay the onset of lower extremity complications and death. We allow for partial observability of the disease stage, unmeasured heterogeneity, and endogenous timing of diabetes screening. Timely diagnosis appears important. We evaluate the effectiveness of two potential policies to reduce the monetary costs of frequent screening in terms of lost longevity. Compared to the status quo, the more restrictive policy yields an implicit value for an additional year of life of about $50,000, while the less restrictive policy implies a value of about $120,000.

  16. Empirical likelihood-based inference in a partially linear model for longitudinal data

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A partially linear model with longitudinal data is considered, empirical likelihood to inference for the regression coefficients and the baseline function is investigated, the empirical log-likelihood ratios is proven to be asymptotically chi-squared, and the corresponding confidence regions for the parameters of interest are then constructed. Also by the empirical likelihood ratio functions, we can obtain the maximum empirical likelihood estimates of the regression coefficients and the baseline function, and prove the asymptotic normality. The numerical results are conducted to compare the performance of the empirical likelihood and the normal approximation-based method, and a real example is analysed.

  17. Empirical likelihood-based inference in a partially linear model for longitudinal data

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A partially linear model with longitudinal data is considered, empirical likelihood to infer- ence for the regression coefficients and the baseline function is investigated, the empirical log-likelihood ratios is proven to be asymptotically chi-squared, and the corresponding confidence regions for the pa- rameters of interest are then constructed. Also by the empirical likelihood ratio functions, we can obtain the maximum empirical likelihood estimates of the regression coefficients and the baseline function, and prove the asymptotic normality. The numerical results are conducted to compare the performance of the empirical likelihood and the normal approximation-based method, and a real example is analysed.

  18. Modeling boyciana-fish-human interaction with partial differential algebraic equations.

    Science.gov (United States)

    Jiang, Yushan; Zhang, Qingling; Wang, Haiyan

    2016-07-01

    Under the influence of human population distribution, the boyciana-fish ecological system is considered. First, the system can be described as a nonlinear partial differential algebraic equations system (PDAEs) with Neumann boundary conditions and ratio-dependent functional response. Second, we examine the system's persistence properties: the loacl stabilities of positive steady states, the absorbtion region and the global stability. And the proposed approach is illustrated by numerical simulation. Finally, by using the realistic data collected in the past fourteen years, the PDAEs parameter optimization model is built to predict the boyciana population.

  19. A queueing model for error control of partial buffer sharing in ATM

    Directory of Open Access Journals (Sweden)

    Ahn Boo Yong

    1999-01-01

    Full Text Available We model the error control of the partial buffer sharing of ATM by a queueing system M 1 , M 2 / G / 1 / K + 1 with threshold and instantaneous Bernoulli feedback. We first derive the system equations and develop a recursive method to compute the loss probabilities at an arbitrary time epoch. We then build an approximation scheme to compute the mean waiting time of each class of cells. An algorithm is developed for finding the optimal threshold and queue capacity for a given quality of service.

  20. Exact diffusion constant for the one-dimensional partially asymmetric exclusion model

    Science.gov (United States)

    Derrida, B.; Mallick, K.

    1997-02-01

    We calculate exactly the diffusion constant associated with the fluctuations of the current for the partial asymmetric exclusion model on a ring with an arbitrary number of particles and holes. We also give the diffusion constant of a tagged particle on that ring. Our approach extends, using the deformed harmonic oscillator algebra, a result already known for the fully asymmetric case. In the limit of weak asymmetry, we extract from our exact expression the crossover between the Edwards - Wilkinson and the Kardar - Parisi - Zhang equations in (1 + 1) dimensions.

  1. Iterative Weighted Semiparametric Least Squares Estimation in Repeated Measurement Partially Linear Regression Models

    Institute of Scientific and Technical Information of China (English)

    Ge-mai Chen; Jin-hong You

    2005-01-01

    Consider a repeated measurement partially linear regression model with an unknown vector pasemiparametric generalized least squares estimator (SGLSE) ofβ, we propose an iterative weighted semiparametric least squares estimator (IWSLSE) and show that it improves upon the SGLSE in terms of asymptotic covariance matrix. An adaptive procedure is given to determine the number of iterations. We also show that when the number of replicates is less than or equal to two, the IWSLSE can not improve upon the SGLSE.These results are generalizations of those in [2] to the case of semiparametric regressions.

  2. Variable Selection for Semiparametric Varying-Coefficient Partially Linear Models with Missing Response at Random

    Institute of Scientific and Technical Information of China (English)

    Pei Xin ZHAO; Liu Gen XUE

    2011-01-01

    In this paper,we present a variable selection procedure by combining basis function approximations with penalized estimating equations for semiparametric varying-coefficient partially linear models with missing response at random.The proposed procedure simultaneously selects significant variables in parametric components and nonparametric components.With appropriate selection of the tuning parameters,we establish the consistency of the variable selection procedure and the convergence rate of the regularized estimators.A simulation study is undertaken to assess the finite sample performance of the proposed variable selection procedure.

  3. Variable Selection in the Partially Linear Errors-in-Variables Models for Longitudinal Data

    Institute of Scientific and Technical Information of China (English)

    Yi-ping YANG; Liu-gen XUE; Wei-hu CHENG

    2012-01-01

    This paper proposes a new approach for variable selection in partially linear errors-in-variables (EV) models for longitudinal data by penalizing appropriate estimating functions.We apply the SCAD penalty to simultaneously select significant variables and estimate unknown parameters.The rate of convergence and the asymptotic normality of the resulting estimators are established.Furthermore,with proper choice of regularization parameters,we show that the proposed estimators perform as well as the oracle procedure.A new algorithm is proposed for solving penalized estimating equation.The asymptotic results are augmented by a simulation study.

  4. Linear Mixture Models and Partial Unmixing in Multi- and Hyperspectral Image Data

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg

    1998-01-01

    As a supplement or an alternative to classification of hyperspectral image data the linear mixture model is considered in order to obtain estimates of abundance of each class or end-member in pixels with mixed membership. Full unmixing and the partial unmixing methods orthogonal subspace projection...... (OSP), constrained energy minimization (CEM) and an eigenvalue formulation alternative are dealt with. The solution to the eigenvalue formulation alternative proves to be identical to the CEM solution. The matrix inversion involved in CEM can be avoided by working on (a subset of) orthogonally...

  5. Chronic heart failure model with sequential ligation of the homonymous artery and its diagonal branch in the sheep.

    Science.gov (United States)

    Kim, W G; Park, J J; Oh, S I

    2001-01-01

    We report a reliable chronic heart failure model in sheep using sequential ligation of the homonymous artery and its diagonal branch. After a left anterior thoracotomy in Corridale sheep, the homonymous artery was ligated at a point approximately 40% of the distance from the apex to the base of the heart, and after 1 hour, the diagonal vessel was ligated at a point at the same level. Hemodynamic measurements were done preligation, 30 minutes after the homonymous artery ligation, and 1 hour after diagonal branch ligation. The electrocardiograms were obtained as needed, and cardiac function was also evaluated with ultrasonography. After a predetermined interval (2 months for five animals and 3 months for two animals), the animals were reevaluated in the same way as before, and were killed for postmortem examination of their hearts. All seven animals survived the experimental procedures. Statistically significant decreases in systemic arterial blood pressure and cardiac output and increases in pulmonary artery capillary wedge pressure were observed 1 hour after sequential ligation of the homonymous artery and its diagonal branch. Untrasonographic analyses demonstrated variable degrees of anteroseptal dyskinesia and akinesia in all animals. The data from animals at 2 months after coronary artery ligation showed significant increases in central venous pressure, pulmonary artery pressure, and pulmonary artery capillary wedge pressure. Left ventricular enddiastolic dimension and left ventricular end-systolic dimension on ultrasonographic studies were also increased. Electrocardiography showed severe ST elevation immediately after the ligation and pathologic Q waves were found at 2 months after ligation. The thin walled infarcted areas with chamber enlargement were clearly seen in the hearts removed at 2 and 3 months after ligation. In conclusion, we could achieve a reliable ovine model of chronic heart failure using a simple concept of sequential ligation of the

  6. A Model for Tow Impregnation and Consolidation for Partially Impregnated Thermoset Prepregs

    Energy Technology Data Exchange (ETDEWEB)

    John J. Gangloff Jr; Shatil Sinha; Suresh G. Advani

    2011-05-23

    The formation and transport of voids in composite materials remains a key research area in composite manufacturing science. Knowledge of how voids, resin, and fiber reinforcement propagate throughout a composite material continuum from green state to cured state during an automated tape layup process is key to minimizing defects induced by void-initiated stress concentrations under applied loads for a wide variety of composite applications. This paper focuses on modeling resin flow in a deforming fiber tow during an automated process of partially impregnated thermoset prepreg composite material tapes. In this work, a tow unit cell based model has been presented that determines the consolidation and impregnation of a thermoset prepreg tape under an input pressure profile. A parametric study has been performed to characterize the behavior of varying tow speed and compaction forces on the degree of consolidation. Results indicate that increased tow consolidation is achieved with slower tow speeds and higher compaction forces although the relationship is not linear. The overall modeling of this project is motivated to address optimization of the 'green state' composite properties and processing parameters to reduce or eliminate 'cured state' defects, such as porosity and de-lamination. This work is partially funded by the Department of Energy under Award number DE-EE0001367.

  7. A simple one-step chemistry model for partially premixed hydrocarbon combustion

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Tarrazo, Eduardo [Instituto Nacional de Tecnica Aeroespacial, Madrid (Spain); Sanchez, Antonio L. [Area de Mecanica de Fluidos, Universidad Carlos III de Madrid, Leganes 28911 (Spain); Linan, Amable [ETSI Aeronauticos, Pl. Cardenal Cisneros 3, Madrid 28040 (Spain); Williams, Forman A. [Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA 92093-0411 (United States)

    2006-10-15

    This work explores the applicability of one-step irreversible Arrhenius kinetics with unity reaction order to the numerical description of partially premixed hydrocarbon combustion. Computations of planar premixed flames are used in the selection of the three model parameters: the heat of reaction q, the activation temperature T{sub a}, and the preexponential factor B. It is seen that changes in q with equivalence ratio f need to be introduced in fuel-rich combustion to describe the effect of partial fuel oxidation on the amount of heat released, leading to a universal linear variation q(f) for f>1 for all hydrocarbons. The model also employs a variable activation temperature T{sub a}(f) to mimic changes in the underlying chemistry in rich and very lean flames. The resulting chemistry description is able to reproduce propagation velocities of diluted and undiluted flames accurately over the whole flammability limit. Furthermore, computations of methane-air counterflow diffusion flames are used to test the proposed chemistry under nonpremixed conditions. The model not only predicts the critical strain rate at extinction accurately but also gives near-extinction flames with oxygen leakage, thereby overcoming known predictive limitations of one-step Arrhenius kinetics. (author)

  8. Partial synchronization in networks of non-linearly coupled oscillators: The Deserter Hubs Model

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Celso, E-mail: cbnfreitas@gmail.com; Macau, Elbert, E-mail: elbert.macau@inpe.br [Associate Laboratory for Computing and Applied Mathematics - LAC, Brazilian National Institute for Space Research - INPE (Brazil); Pikovsky, Arkady, E-mail: pikovsky@uni-potsdam.de [Department of Physics and Astronomy, University of Potsdam, Germany and Department of Control Theory, Nizhni Novgorod State University, Gagarin Av. 23, 606950, Nizhni Novgorod (Russian Federation)

    2015-04-15

    We study the Deserter Hubs Model: a Kuramoto-like model of coupled identical phase oscillators on a network, where attractive and repulsive couplings are balanced dynamically due to nonlinearity of interactions. Under weak force, an oscillator tends to follow the phase of its neighbors, but if an oscillator is compelled to follow its peers by a sufficient large number of cohesive neighbors, then it actually starts to act in the opposite manner, i.e., in anti-phase with the majority. Analytic results yield that if the repulsion parameter is small enough in comparison with the degree of the maximum hub, then the full synchronization state is locally stable. Numerical experiments are performed to explore the model beyond this threshold, where the overall cohesion is lost. We report in detail partially synchronous dynamical regimes, like stationary phase-locking, multistability, periodic and chaotic states. Via statistical analysis of different network organizations like tree, scale-free, and random ones, we found a measure allowing one to predict relative abundance of partially synchronous stationary states in comparison to time-dependent ones.

  9. Analysis and Modeling of Parallel Photovoltaic Systems under Partial Shading Conditions

    Science.gov (United States)

    Buddala, Santhoshi Snigdha

    Since the industrial revolution, fossil fuels like petroleum, coal, oil, natural gas and other non-renewable energy sources have been used as the primary energy source. The consumption of fossil fuels releases various harmful gases into the atmosphere as byproducts which are hazardous in nature and they tend to deplete the protective layers and affect the overall environmental balance. Also the fossil fuels are bounded resources of energy and rapid depletion of these sources of energy, have prompted the need to investigate alternate sources of energy called renewable energy. One such promising source of renewable energy is the solar/photovoltaic energy. This work focuses on investigating a new solar array architecture with solar cells connected in parallel configuration. By retaining the structural simplicity of the parallel architecture, a theoretical small signal model of the solar cell is proposed and modeled to analyze the variations in the module parameters when subjected to partial shading conditions. Simulations were run in SPICE to validate the model implemented in Matlab. The voltage limitations of the proposed architecture are addressed by adopting a simple dc-dc boost converter and evaluating the performance of the architecture in terms of efficiencies by comparing it with the traditional architectures. SPICE simulations are used to compare the architectures and identify the best one in terms of power conversion efficiency under partial shading conditions.

  10. The Spectrum of the Partially Locked State for the Kuramoto Model

    Science.gov (United States)

    Mirollo, R.; Strogatz, S. H.

    2007-08-01

    We solve a long-standing stability problem for the Kuramoto model of coupled oscillators. This system has attracted mathematical attention, in part because of its applications in fields ranging from neuroscience to condensed-matter physics, and also because it provides a beautiful connection between nonlinear dynamics and statistical mechanics. The model consists of a large population of phase oscillators with all-to-all sinusoidal coupling. The oscillators' intrinsic frequencies are randomly distributed across the population according to a prescribed probability density, here taken to be unimodal and symmetric about its mean. As the coupling between the oscillators is increased, the system spontaneously synchronizes: The oscillators near the center of the frequency distribution lock their phases together and run at the same frequency, while those in the tails remain unlocked and drift at different frequencies. Although this "partially locked" state has been observed in simulations for decades, its stability has never been analyzed mathematically. Part of the difficulty is in formulating a reasonable infinite-N limit of the model. Here we describe such a continuum limit, and prove that the corresponding partially locked state is, in fact, neutrally stable, contrary to what one might have expected. The possible implications of this result are discussed.

  11. Partial Least Squares Regression Model to Predict Water Quality in Urban Water Distribution Systems

    Institute of Scientific and Technical Information of China (English)

    LUO Bijun; ZHAO Yuan; CHEN Kai; ZHAO Xinhua

    2009-01-01

    The water distribution system of one residential district in Tianjin is taken as an example to analyze the changes of water quality. Partial least squares (PLS) regression model, in which the turbidity and Fe are regarded as con-trol objectives, is used to establish the statistical model. The experimental results indicate that the PLS regression model has good predicted results of water quality compared with the monitored data. The percentages of absolute relative error (below 15%, 20%, 30%) are 44.4%, 66.7%, 100% (turbidity) and 33.3%, 44.4%, 77.8% (Fe) on the 4th sampling point; 77.8%, 88.9%, 88.9% (turbidity) and 44.4%, 55.6%, 66.7% (Fe) on the 5th sampling point.

  12. Modeling treatment of ischemic heart disease with partially observable Markov decision processes.

    Science.gov (United States)

    Hauskrecht, M; Fraser, H

    1998-01-01

    Diagnosis of a disease and its treatment are not separate, one-shot activities. Instead they are very often dependent and interleaved over time, mostly due to uncertainty about the underlying disease, uncertainty associated with the response of a patient to the treatment and varying cost of different diagnostic (investigative) and treatment procedures. The framework of Partially observable Markov decision processes (POMDPs) developed and used in operations research, control theory and artificial intelligence communities is particularly suitable for modeling such a complex decision process. In the paper, we show how the POMDP framework could be used to model and solve the problem of the management of patients with ischemic heart disease, and point out modeling advantages of the framework over standard decision formalisms.

  13. Statistical inference on parametric part for partially linear single-index model

    Institute of Scientific and Technical Information of China (English)

    ZHANG RiQuan; HUANG ZhenSheng

    2009-01-01

    Statistical inference on parametric part for the partially linear single-index model (PLSIM) is considered in this paper.A profile least-squares technique for estimating the parametric part is proposed and the asymptotic normality of the profile least-squares estimator is given.Based on the estimator,a generalized likelihood ratio (GLR) test is proposed to test whether parameters on linear part for the model is under a contain linear restricted condition.Under the null model,the proposed GLR statistic follows asymptotically the X2-distribution with the scale constant and degree of freedom independent of the nuisance parameters,known as Wilks phenomenon.Both simulated and real data examples are used to illustrate our proposed methods.

  14. Statistical inference on parametric part for partially linear single-index model

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Statistical inference on parametric part for the partially linear single-index model (PLSIM) is considered in this paper. A profile least-squares technique for estimating the parametric part is proposed and the asymptotic normality of the profile least-squares estimator is given. Based on the estimator, a generalized likelihood ratio (GLR) test is proposed to test whether parameters on linear part for the model is under a contain linear restricted condition. Under the null model, the proposed GLR statistic follows asymptotically the χ2-distribution with the scale constant and degree of freedom independent of the nuisance parameters, known as Wilks phenomenon. Both simulated and real data examples are used to illustrate our proposed methods.

  15. Self-potentials in partially saturated media: the importance of explicit modeling of electrode effects

    CERN Document Server

    Jougnot, D

    2013-01-01

    Self-potential (SP) data are of interest to vadose zone hydrology because of their direct sensitivity to water flow and ionic transport. There is unfortunately little consensus in the literature about how to best model SP data under partially saturated conditions and different approaches (often supported by one laboratory data set alone) have been proposed. We argue herein that this lack of agreement can largely be traced to electrode effects that have not been properly taken into account. A series of drainage and imbibition experiments are considered, in which we find that previously proposed approaches to remove electrode effects are unlikely to provide adequate corrections. Instead, we explicitly model the electrode effects together with classical SP contributions using a flow and transport model. The simulated data agree overall with the observed SP signals and allow decomposing the different signal contributions to analyze them separately. By reviewing other published experimental data, we suggest that m...

  16. Continuum Modeling and Control of Large Nonuniform Wireless Networks via Nonlinear Partial Differential Equations

    Directory of Open Access Journals (Sweden)

    Yang Zhang

    2013-01-01

    Full Text Available We introduce a continuum modeling method to approximate a class of large wireless networks by nonlinear partial differential equations (PDEs. This method is based on the convergence of a sequence of underlying Markov chains of the network indexed by N, the number of nodes in the network. As N goes to infinity, the sequence converges to a continuum limit, which is the solution of a certain nonlinear PDE. We first describe PDE models for networks with uniformly located nodes and then generalize to networks with nonuniformly located, and possibly mobile, nodes. Based on the PDE models, we develop a method to control the transmissions in nonuniform networks so that the continuum limit is invariant under perturbations in node locations. This enables the networks to maintain stable global characteristics in the presence of varying node locations.

  17. An EOQ model for imperfect quality items with partial backordering under screening errors

    Directory of Open Access Journals (Sweden)

    Ehsan Sharifi

    2015-12-01

    Full Text Available In practice, when a lot size received, an inspection process is necessary to identify the defective items. In addition, the inspection process itself is not error-free and it may contain misclassification errors. In this paper, an economic order quantity model for imperfect quality items with partial backordering under screening errors is studied. The objective is to maximize the expected annual profit by optimizing the order size and the maximum number of backorder units. Also, the aim of this paper is to develop a general and practical model that is more realistic in the competitive commercial situations. For authenticity of the developed model, a case study and a numerical example are illustrated, and the sensitivity analysis is also carried out.

  18. Partial corrosion casting to assess cochlear vasculature in mouse models of presbycusis and CMV infection.

    Science.gov (United States)

    Carraro, Mattia; Park, Albert H; Harrison, Robert V

    2016-02-01

    Some forms of sensorineural hearing loss involve damage or degenerative changes to the stria vascularis and/or other vascular structures in the cochlea. In animal models, many methods for anatomical assessment of cochlear vasculature exist, each with advantages and limitations. One methodology, corrosion casting, has proved useful in some species, however in the mouse model this technique is difficult to achieve because digestion of non vascular tissue results in collapse of the delicate cast specimen. We have developed a partial corrosion cast method that allows visualization of vasculature along much of the cochlear length but maintains some structural integrity of the specimen. We provide a detailed step-by-step description of this novel technique. We give some illustrative examples of the use of the method in mouse models of presbycusis and cytomegalovirus (CMV) infection.

  19. Internal resonances and dynamic responses in equivalent mechanical model of partially liquid-filled vessel

    Science.gov (United States)

    Farid, M.; Gendelman, O. V.

    2016-09-01

    The paper treats dynamical responses in an equivalent mechanical model for oscillations of a liquid in partially filled vessel under horizontal harmonic ground excitation. Such excitation may lead to hydraulic impacts. The liquid sloshing mass is modeled by equivalent pendulum, which can impact the vessel walls. Parameters of the equivalent pendulum for well-explored case of cylindrical vessels are used. The hydraulic impacts are modeled by high-power potential function. Conditions for internal resonances are formulated. A non-resonant behavior and dynamic response related to 3:1 internal resonance are explored. When the excitation amplitude exceeds certain critical value, the system exhibits multiple steady state solutions. Quasi-periodic solutions appear in relatively narrow range of parameters. Numerical continuation links between resonant regimes found asymptotically for small excitation amplitude, and high-amplitude responses with intensive impacts.

  20. Deterministic Partial Differential Equation Model for Dose Calculation in Electron Radiotherapy

    CERN Document Server

    Duclous, Roland; Frank, Martin

    2009-01-01

    Treatment with high energy ionizing radiation is one of the main methods in modern cancer therapy that is in clinical use. During the last decades, two main approaches to dose calculation were used, Monte Carlo simulations and semi-empirical models based on Fermi-Eyges theory. A third way to dose calculation has only recently attracted attention in the medical physics community. This approach is based on the deterministic kinetic equations of radiative transfer. Starting from these, we derive a macroscopic partial differential equation model for electron transport in tissue. This model involves an angular closure in the phase space. It is exact for the free-streaming and the isotropic regime. We solve it numerically by a newly developed HLLC scheme based on [BerCharDub], that exactly preserves key properties of the analytical solution on the discrete level. Several numerical results for test cases from the medical physics literature are presented.

  1. Bayesian modeling of the covariance structure for irregular longitudinal data using the partial autocorrelation function.

    Science.gov (United States)

    Su, Li; Daniels, Michael J

    2015-05-30

    In long-term follow-up studies, irregular longitudinal data are observed when individuals are assessed repeatedly over time but at uncommon and irregularly spaced time points. Modeling the covariance structure for this type of data is challenging, as it requires specification of a covariance function that is positive definite. Moreover, in certain settings, careful modeling of the covariance structure for irregular longitudinal data can be crucial in order to ensure no bias arises in the mean structure. Two common settings where this occurs are studies with 'outcome-dependent follow-up' and studies with 'ignorable missing data'. 'Outcome-dependent follow-up' occurs when individuals with a history of poor health outcomes had more follow-up measurements, and the intervals between the repeated measurements were shorter. When the follow-up time process only depends on previous outcomes, likelihood-based methods can still provide consistent estimates of the regression parameters, given that both the mean and covariance structures of the irregular longitudinal data are correctly specified and no model for the follow-up time process is required. For 'ignorable missing data', the missing data mechanism does not need to be specified, but valid likelihood-based inference requires correct specification of the covariance structure. In both cases, flexible modeling approaches for the covariance structure are essential. In this paper, we develop a flexible approach to modeling the covariance structure for irregular continuous longitudinal data using the partial autocorrelation function and the variance function. In particular, we propose semiparametric non-stationary partial autocorrelation function models, which do not suffer from complex positive definiteness restrictions like the autocorrelation function. We describe a Bayesian approach, discuss computational issues, and apply the proposed methods to CD4 count data from a pediatric AIDS clinical trial. © 2015 The Authors

  2. Transient blood flow in elastic coronary arteries with varying degrees of stenosis and dilatations: CFD modelling and parametric study.

    Science.gov (United States)

    Wu, Jianhuang; Liu, Guiying; Huang, Wenhua; Ghista, Dhanjoo N; Wong, Kelvin K L

    2015-01-01

    In this paper, we have analysed pulsatile flow through partially occluded elastic arteries, to determine the haemodynamic parameters of wall shear stress (WSS), wall pressure gradient and pressure drops (ΔP), contributing to enhanced flow resistance and myocardial ischaemic regions which impair cardiac contractility and cause increased work load on the heart. In summary, it can be observed that stenoses in an artery significantly influence the haemodynamic parameters of wall shear stress and pressure drop in contrast to dilatations case. This deduces that stenosis plays a more critical role in plaque growth and vulnerability in contrast to dilatation, and should be the key element in cardiovascular pathology and diagnosis. Through quantitative analysis of WSS and ΔP, we have provided a clearer insight into the haemodynamics of atherosclerotic arteries. Determination of these parameters can be helpful to cardiologists, because it is directly implicated in the genesis and development of atherosclerosis.

  3. Model Partial Least Square Regression (PLSR Pengaruh Bidang Pendidikan dan Ekonomi Terhadap Tingkat Kemiskinan di Indonesia

    Directory of Open Access Journals (Sweden)

    I Gusti Ayu Made Srinadi

    2017-06-01

    Full Text Available Partial Least Square Regression (PLSR  is one of the methods applied in the estimation of multiple linear regression models when the ordinary least square method  (OLS can not be used. OLS generates an invalid model estimate when multicollinearity occurs or when the number of independent variables is greater than the number of data observations. In conditions that OLS can be applied in obtaining model estimation, want to know the performance of PLSR method. This study aims to determine the model of PLSR the influence of literacy rate, the average of school duration,  school enrollment rate, Income per capita, and open unemployment rate to the level of poverty seen from the percentage of poor people in Indonesia by 2015. Estimated model with OLS , Only variable of literacy rate  are included in the model with the coefficient of determination R2 = 32.52%. PLSR model estimation of cross-validation, leave-one-out method with one selected component has R2 of 33,23%. Both models shows  a negative relationship between poverty and literacy rate. The higher literacy rate will reduce the poverty level, indicating that the success of the Indonesian government in the development of education will support the government's success in reducing poverty level.

  4. The ARMA model's pole characteristics of Doppler signals from the carotid artery and their classification application

    Institute of Scientific and Technical Information of China (English)

    CHEN Xi; WANG Yuanyuan; ZHANG Yu; WANG Weiqi

    2002-01-01

    In order to diagnose the cerebral infarction, a classification system based onthe ARMA model and BP (Back-Propagation) neural network is presented to analyzeblood flow Doppler signals from the carotid artery. In this system, an ARMA modelis first used to analyze the audio Doppler blood flow signals from the carotid artery.Then several characteristic parameters of the pole's distribution are estimated. Afterstudies of these characteristic parameters' sensitivity to the textcolor cerebral infarctiondiagnosis, a BP neural network using sensitive parameters is established to classify thenormal or abnormal state of the cerebral vessel. With 474 cases used to establish theappropriate neural network, and 52 cases used to test the network, the results showthat the correct classification rate of both training and testing are over 94%. Thus thissystem is useful to diagnose the cerebral infarction.

  5. Organ culture of C57BL/6 mouse arteries with LPS as an in vitro model of vascular inflammation

    DEFF Research Database (Denmark)

    Outzen, Emilie Middelbo; Mehryar, Rahila; Boonen, Harrie C.M.

    an in vitro model for studying vascular inflammation and function in cultured arteries from C57BL/6 mice. Methods: Segments of abdominal aorta and mesenteric arteries (MA) were incubated for 24 hours at 37̊C and 95% O2/5% CO2 in DMEM ± 100 ng/mL LPS. Aorta segments were frozen for molecular studies....... The in vitro model allows further assessment of relevant vasoactive systems and studies of possible protective mediators....

  6. Implications of the partial width Z --> bb for supersymmetry searches and model-building

    CERN Document Server

    Wells, J D; Kane, G L; James D Wells; Chris Kolda

    1994-01-01

    Assuming that the actual values of the top quark mass at FNAL and of the ratio of partial widths Z->bb/Z->hadrons at LEP are within their current one-sigma reported ranges, we present a No-Lose Theorem for superpartner searches at LEP II and an upgraded Tevatron. We impose only two theoretical assumptions: the Lagrangian is that of the Minimal Supersymmetric Standard Model with arbitrary soft-breaking terms, and all couplings remain perturbative up to scales of order 10^16 GeV; there are no assumptions about the soft SUSY breaking parameters, proton decay, cosmology, etc. In particular, if the LEP and FNAL values hold up and supersymmetry is responsible for the discrepancy with the SM prediction of the partial width of Z->bb, then we must have charginos and/or top squarks observable at the upgraded machines. Furthermore, little deviation from the SM is predicted within "super-unified" SUSY. Finally, it appears to be extremely difficult to find any unified MSSM model, regardless of the form of soft SUSY breaki...

  7. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

    Science.gov (United States)

    Jones, Nicholas A; Glyn, Sarah E; Akiyama, Satoshi; Hill, Thomas D M; Hill, Andrew J; Weston, Samantha E; Burnett, Matthew D A; Yamasaki, Yuki; Stephens, Gary J; Whalley, Benjamin J; Williams, Claire M

    2012-06-01

    Cannabis sativa has been associated with contradictory effects upon seizure states despite its medicinal use by numerous people with epilepsy. We have recently shown that the phytocannabinoid cannabidiol (CBD) reduces seizure severity and lethality in the well-established in vivo model of pentylenetetrazole-induced generalised seizures, suggesting that earlier, small-scale clinical trials examining CBD effects in people with epilepsy warrant renewed attention. Here, we report the effects of pure CBD (1, 10 and 100mg/kg) in two other established rodent seizure models, the acute pilocarpine model of temporal lobe seizure and the penicillin model of partial seizure. Seizure activity was video recorded and scored offline using model-specific seizure severity scales. In the pilocarpine model CBD (all doses) significantly reduced the percentage of animals experiencing the most severe seizures. In the penicillin model, CBD (≥ 10 mg/kg) significantly decreased the percentage mortality as a result of seizures; CBD (all doses) also decreased the percentage of animals experiencing the most severe tonic-clonic seizures. These results extend the anti-convulsant profile of CBD; when combined with a reported absence of psychoactive effects, this evidence strongly supports CBD as a therapeutic candidate for a diverse range of human epilepsies. Copyright © 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  8. A Cost Model of Partial Postponement Strategy of the Single-Period Product under Stochastic Demand

    Directory of Open Access Journals (Sweden)

    Yanhong Qin

    2012-06-01

    Full Text Available The target of our study is to set a new cost model to solve the partial postponement problem by adding penalty cost parameter of shortage under stochastic demand. By doing this, we hope the new model can be better applied to real conditions. Postponement is an important strategy to achieve mass customization and it has been adopted by many companies to improve production operation, inventory and logistics management and supply chain operation, but the postponed activity will cause additional costs at the same time. There have been many literatures trading off between the relative cost and the postponement benefits of product manufacture, and our paper is to solve the similar problem.

  9. Internal resonances and dynamic responses in equivalent mechanical model of partially liquid-filled vessel

    CERN Document Server

    Farid, Maor

    2016-01-01

    The paper treats oscillations of a liquid in partially filled vessel under horizontal harmonic ground excitation. Such excitation may lead to hydraulic impacts. The liquid sloshing mass is modeled by equivalent pendulum, which can impact the vessel walls. We use parameters of the equivalent pendulum for well-explored case of cylindrical vessels. The hydraulic impacts are modeled by high-power potential function. Conditions for internal resonances are presented. A non-resonant behavior and dynamic response related to 3:1 internal resonance are explored. When the excitation amplitude exceeds a critical value, the system exhibits multiple steady state solutions. Quasi-periodic solutions appear in relatively narrow range of parameters. Numerical continuation links between resonant regimes found asymptotically for small excitation amplitude, and high-amplitude responses with intensive impacts.

  10. Partial Optimality by Pruning for MAP-Inference with General Graphical Models.

    Science.gov (United States)

    Swoboda, Paul; Shekhovtsov, Alexander; Kappes, Jorg Hendrik; Schnorr, Christoph; Savchynskyy, Bogdan

    2016-07-01

    We consider the energy minimization problem for undirected graphical models, also known as MAP-inference problem for Markov random fields which is NP-hard in general. We propose a novel polynomial time algorithm to obtain a part of its optimal non-relaxed integral solution. Our algorithm is initialized with variables taking integral values in the solution of a convex relaxation of the MAP-inference problem and iteratively prunes those, which do not satisfy our criterion for partial optimality. We show that our pruning strategy is in a certain sense theoretically optimal. Also empirically our method outperforms previous approaches in terms of the number of persistently labelled variables. The method is very general, as it is applicable to models with arbitrary factors of an arbitrary order and can employ any solver for the considered relaxed problem. Our method's runtime is determined by the runtime of the convex relaxation solver for the MAP-inference problem.

  11. Partial least squares modeling and genetic algorithm optimization in quantitative structure-activity relationships.

    Science.gov (United States)

    Hasegawa, K; Funatsu, K

    2000-01-01

    Quantitative structure-activity relationship (QSAR) studies based on chemometric techniques are reviewed. Partial least squares (PLS) is introduced as a novel robust method to replace classical methods such as multiple linear regression (MLR). Advantages of PLS compared to MLR are illustrated with typical applications. Genetic algorithm (GA) is a novel optimization technique which can be used as a search engine in variable selection. A novel hybrid approach comprising GA and PLS for variable selection developed in our group (GAPLS) is described. The more advanced method for comparative molecular field analysis (CoMFA) modeling called GA-based region selection (GARGS) is described as well. Applications of GAPLS and GARGS to QSAR and 3D-QSAR problems are shown with some representative examples. GA can be hybridized with nonlinear modeling methods such as artificial neural networks (ANN) for providing useful tools in chemometric and QSAR.

  12. Rule-Driven Object Tracking in Clutter and Partial Occlusion with Model-Based Snakes

    Directory of Open Access Journals (Sweden)

    Rapantzikos Konstantinos

    2004-01-01

    Full Text Available In the last few years it has been made clear to the research community that further improvements in classic approaches for solving low-level computer vision and image/video understanding tasks are difficult to obtain. New approaches started evolving, employing knowledge-based processing, though transforming a priori knowledge to low-level models and rules are far from being straightforward. In this paper, we examine one of the most popular active contour models, snakes, and propose a snake model, modifying terms and introducing a model-based one that eliminates basic problems through the usage of prior shape knowledge in the model. A probabilistic rule-driven utilization of the proposed model follows, being able to handle (or cope with objects of different shapes, contour complexities and motions; different environments, indoor and outdoor; cluttered sequences; and cases where background is complex (not smooth and when moving objects get partially occluded. The proposed method has been tested in a variety of sequences and the experimental results verify its efficiency.

  13. Discovering novel phenotypes with automatically inferred dynamic models: a partial melanocyte conversion in Xenopus

    Science.gov (United States)

    Lobo, Daniel; Lobikin, Maria; Levin, Michael

    2017-01-01

    Progress in regenerative medicine requires reverse-engineering cellular control networks to infer perturbations with desired systems-level outcomes. Such dynamic models allow phenotypic predictions for novel perturbations to be rapidly assessed in silico. Here, we analyzed a Xenopus model of conversion of melanocytes to a metastatic-like phenotype only previously observed in an all-or-none manner. Prior in vivo genetic and pharmacological experiments showed that individual animals either fully convert or remain normal, at some characteristic frequency after a given perturbation. We developed a Machine Learning method which inferred a model explaining this complex, stochastic all-or-none dataset. We then used this model to ask how a new phenotype could be generated: animals in which only some of the melanocytes converted. Systematically performing in silico perturbations, the model predicted that a combination of altanserin (5HTR2 inhibitor), reserpine (VMAT inhibitor), and VP16-XlCreb1 (constitutively active CREB) would break the all-or-none concordance. Remarkably, applying the predicted combination of three reagents in vivo revealed precisely the expected novel outcome, resulting in partial conversion of melanocytes within individuals. This work demonstrates the capability of automated analysis of dynamic models of signaling networks to discover novel phenotypes and predictively identify specific manipulations that can reach them. PMID:28128301

  14. Discovering novel phenotypes with automatically inferred dynamic models: a partial melanocyte conversion in Xenopus

    Science.gov (United States)

    Lobo, Daniel; Lobikin, Maria; Levin, Michael

    2017-01-01

    Progress in regenerative medicine requires reverse-engineering cellular control networks to infer perturbations with desired systems-level outcomes. Such dynamic models allow phenotypic predictions for novel perturbations to be rapidly assessed in silico. Here, we analyzed a Xenopus model of conversion of melanocytes to a metastatic-like phenotype only previously observed in an all-or-none manner. Prior in vivo genetic and pharmacological experiments showed that individual animals either fully convert or remain normal, at some characteristic frequency after a given perturbation. We developed a Machine Learning method which inferred a model explaining this complex, stochastic all-or-none dataset. We then used this model to ask how a new phenotype could be generated: animals in which only some of the melanocytes converted. Systematically performing in silico perturbations, the model predicted that a combination of altanserin (5HTR2 inhibitor), reserpine (VMAT inhibitor), and VP16-XlCreb1 (constitutively active CREB) would break the all-or-none concordance. Remarkably, applying the predicted combination of three reagents in vivo revealed precisely the expected novel outcome, resulting in partial conversion of melanocytes within individuals. This work demonstrates the capability of automated analysis of dynamic models of signaling networks to discover novel phenotypes and predictively identify specific manipulations that can reach them.

  15. Modeling and optimization of the combined carbon dioxide reforming and partial oxidation of natural gas

    Energy Technology Data Exchange (ETDEWEB)

    Larentis, A.L.; De Resende, N.S.; Salim, V.M.M.; Pinto, J.C. [Programa de Engenharia Quimica/COPPE/Universidade Federal do Rio de Janeiro, Cidade Universitaria, CP 68502, RJ, 21945-970 Rio de Janeiro (Brazil)

    2001-07-13

    The optimization of the combined carbon dioxide reforming and partial methane oxidation over a 1% Pt/{gamma}-Al{sub 2}O{sub 3} catalyst was studied in order to produce synthesis gas with hydrogen/carbon monoxide ratio close to 1, for applications in metallurgical and polycarbonates processes and for production of oxygenated compounds and hydrocarbons. The study was performed with the help of experimental design and two mathematical modeling approaches: empirical and phenomenological. Empirical polynomial models were employed to analyze the effects of the process variables on the response factors and the final correlation coefficients obtained were above 95%. The phenomenological model was obtained from individual mass balances and the obtained correlation coefficients were above 95% for CH{sub 4} and N{sub 2}, 90% for CO{sub 2} and H{sub 2}O and near 70% for H{sub 2} and CO. The empirical modeling approach was found to be more efficient, simpler and led to better results than those obtained with the phenomenological model approach. Therefore, the empirical modeling was used for optimization of the process operation conditions. At an oxygen/methane ratio of 0.55gmol/gmol and temperature of 950C, optimized process conditions were obtained with complete methane conversion, maximum carbon monoxide selectivity of 43% and minimum hydrogen/carbon monoxide ratio of 1.3, in absence of water.

  16. Joint partially linear model for longitudinal data with informative drop-outs.

    Science.gov (United States)

    Kim, Sehee; Zeng, Donglin; Taylor, Jeremy M G

    2017-03-01

    In biomedical research, a steep rise or decline in longitudinal biomarkers may indicate latent disease progression, which may subsequently cause patients to drop out of the study. Ignoring the informative drop-out can cause bias in estimation of the longitudinal model. In such cases, a full parametric specification may be insufficient to capture the complicated pattern of the longitudinal biomarkers. For these types of longitudinal data with the issue of informative drop-outs, we develop a joint partially linear model, with an aim to find the trajectory of the longitudinal biomarker. Specifically, an arbitrary function of time along with linear fixed and random covariate effects is proposed in the model for the biomarker, while a flexible semiparametric transformation model is used to describe the drop-out mechanism. Advantages of this semiparametric joint modeling approach are the following: 1) it provides an easier interpretation, compared to standard nonparametric regression models, and 2) it is a natural way to control for common (observable and unobservable) prognostic factors that may affect both the longitudinal trajectory and the drop-out process. We describe a sieve maximum likelihood estimation procedure using the EM algorithm, where the Akaike information criterion (AIC) and Bayesian information criterion (BIC) are considered to select the number of knots. We show that the proposed estimators achieve desirable asymptotic properties through empirical process theory. The proposed methods are evaluated by simulation studies and applied to prostate cancer data.

  17. Efficient semiparametric estimation in generalized partially linear additive models for longitudinal/clustered data

    KAUST Repository

    Cheng, Guang

    2014-02-01

    We consider efficient estimation of the Euclidean parameters in a generalized partially linear additive models for longitudinal/clustered data when multiple covariates need to be modeled nonparametrically, and propose an estimation procedure based on a spline approximation of the nonparametric part of the model and the generalized estimating equations (GEE). Although the model in consideration is natural and useful in many practical applications, the literature on this model is very limited because of challenges in dealing with dependent data for nonparametric additive models. We show that the proposed estimators are consistent and asymptotically normal even if the covariance structure is misspecified. An explicit consistent estimate of the asymptotic variance is also provided. Moreover, we derive the semiparametric efficiency score and information bound under general moment conditions. By showing that our estimators achieve the semiparametric information bound, we effectively establish their efficiency in a stronger sense than what is typically considered for GEE. The derivation of our asymptotic results relies heavily on the empirical processes tools that we develop for the longitudinal/clustered data. Numerical results are used to illustrate the finite sample performance of the proposed estimators. © 2014 ISI/BS.

  18. Secondary flow structure in a model curved artery: 3D morphology and circulation budget analysis

    Science.gov (United States)

    Bulusu, Kartik V.; Plesniak, Michael W.

    2015-11-01

    In this study, we examined the rate of change of circulation within control regions encompassing the large-scale vortical structures associated with secondary flows, i.e. deformed Dean-, Lyne- and Wall-type (D-L-W) vortices at planar cross-sections in a 180° curved artery model (curvature ratio, 1/7). Magnetic resonance velocimetry (MRV) and particle image velocimetry (PIV) experiments were performed independently, under the same physiological inflow conditions (Womersley number, 4.2) and using Newtonian blood-analog fluids. The MRV-technique performed at Stanford University produced phase-averaged, three-dimensional velocity fields. Secondary flow field comparisons of MRV-data to PIV-data at various cross-sectional planes and inflow phases were made. A wavelet-decomposition-based approach was implemented to characterize various secondary flow morphologies. We hypothesize that the persistence and decay of arterial secondary flow vortices is intrinsically related to the influence of the out-of-plane flow, tilting, in-plane convection and diffusion-related factors within the control regions. Evaluation of these factors will elucidate secondary flow structures in arterial hemodynamics. Supported by the National Science Foundation under Grant Number CBET-0828903, and GW Center for Biomimetics and Bioinspired Engineering (COBRE). The MRV data were acquired at Stanford University in collaboration with Christopher Elkins and John Eaton.

  19. Simultaneous modelling of operative mortality and long-term survival after coronary artery bypass surgery.

    Science.gov (United States)

    Ghahramani, M; Dean, C B; Spinelli, J J

    2001-07-15

    Typical analyses of lifetime data treat the time to death or failure as the response variable and use a variety of modelling strategies such as proportional hazards or fully parametric, to investigate the relationship between the response and covariates. In certain circumstances it may be more natural to view the distribution of the response variable as consisting of two or more parts since the survival curve appears segmented. This article addresses such a scenario and we propose a model for simultaneously investigating the effects of covariates over the two segments. The model is an analogue of that proposed by Lambert for zero-inflated Poisson regression. The application is central to the model development and is concerned with survival after coronary artery bypass surgery. Here operative mortality, defined as death within 30 days after surgery, and long-term mortality, are viewed as distinct outcomes. For the application considered, the survivor function displays much steeper descent during the first 30 days after surgery, that is, for operative mortality, than after this period. An investigation of the effects of covariates on operative and long-term mortality after coronary artery bypass surgery illustrates the usefulness of the proposed model.

  20. A laboratory model of the aortic root flow including the coronary arteries

    Science.gov (United States)

    Querzoli, Giorgio; Fortini, Stefania; Espa, Stefania; Melchionna, Simone

    2016-08-01

    Cardiovascular flows have been extensively investigated by means of in vitro models to assess the prosthetic valve performances and to provide insight into the fluid dynamics of the heart and proximal aorta. In particular, the models for the study of the flow past the aortic valve have been continuously improved by including, among other things, the compliance of the vessel and more realistic geometries. The flow within the sinuses of Valsalva is known to play a fundamental role in the dynamics of the aortic valve since they host a recirculation region that interacts with the leaflets. The coronary arteries originate from the ostia located within two of the three sinuses, and their presence may significantly affect the fluid dynamics of the aortic root. In spite of their importance, to the extent of the authors' knowledge, coronary arteries were not included so far when modeling in vitro the transvalvular aortic flow. We present a pulse duplicator consisting of a passively pulsing ventricle, a compliant proximal aorta, and coronary arteries connected to the sinuses of Valsalva. The coronary flow is modulated by a self-regulating device mimicking the physiological mechanism, which is based on the contraction and relaxation of the heart muscle during the cardiac cycle. Results show that the model reproduces satisfyingly the coronary flow. The analysis of the time evolution of the velocity and vorticity fields within the aortic root reveals the main characteristics of the backflow generated through the aorta in order to feed the coronaries during the diastole. Experiments without coronary flow have been run for comparison. Interestingly, the lifetime of the vortex forming in the sinus of Valsalva during the systole is reduced by the presence of the coronaries. As a matter of fact, at the end of the systole, that vortex is washed out because of the suction generated by the coronary flow. Correspondingly, the valve closure is delayed and faster compared to the case with

  1. Snowpack Microstructure Characterization and Partial Coherent and Fully Coherent Forward Scattering Models in Microwave Remote Sensing

    Science.gov (United States)

    Tan, S.; Tsang, L.; Xu, X.; Ding, K. H.

    2015-12-01

    In this paper we describe partial coherent model and fully coherent snowpack scattering model based on numerical simulation of Maxwell's equation. In medium characterization, we derive the correlation functions from the pair distribution functions of sticky spheres and multiple-size spheres used in QCA. We show that both the Percus-Yevick pair functions and the bicontinuous model have tails in the correlation functions that are distinctly different from the traditional exponential correlation functions. The methodologies of using ground measurements of grain size distributions and correlation functions to obtain model parameters are addressed. The DMRT theory has been extended to model the backscattering enhancement. We developed the methodology of cyclical corrections beyond first order to all orders of multiple scattering. This enables the physical modeling of combined active and passive microwave remote sensing of snow over the same scene. The bicontinuous /DMRT is applied to compare with data acquired in the NoSREx campaign, and the model results are validated against coincidental active and passive measurements using the same set of physical parameters of snow in all frequency and polarization channels. The DMRT is a partially coherent approach that one accounts for the coherent wave interaction only within few wavelengths as represented by phase matrix. However, the phase information of field is lost in propagating the specific intensity via RT and this hinders the use of DMRT in coherent synthetic aperture radar (SAR) analysis, including InSAR, PolInSAR and Tomo-SAR. One can alternatively calculate the scattering matrix of the terrestrial snowpack above ground by solving the volume integral equations directly with half space Green's function. The scattering matrix of the snowpack is computed for each realization giving rise to the speckle statistics. The resulting bistatic scattering automatically includes the backscattering enhancement effects. Tomograms of

  2. Including Flocculation in a Numerical Sediment Transport Model for a Partially-Mixed Estuary

    Science.gov (United States)

    Tarpley, D.; Harris, C. K.; Friedrichs, C. T.

    2016-12-01

    Particle settling velocity impacts the transport of suspended sediment to the first order but fine-grained material like muds tend to form loosely bound aggregates (flocs) whose settling velocity can vary widely. Properties of flocculated sediment such as settling velocity and particle density are difficult to predict because they change in response to several factors including salinity, suspended sediment concentration, turbulent mixing, and organic content. Knowledge of the mechanisms governing flocculation of cohesive sediment is rapidly expanding; especially in response to recent technical advances. As the understanding of particle dynamics progresses, numerical models describing flocculation and break-up are being developed with varying degrees of complexity. While complex models capture the dynamics of the system, their computational costs may prohibit their incorporation into larger model domains. It is important to determine if the computational costs of intricate floc models are justifiable compared to simpler formulations. For this study, we implement an idealized two-dimensional model designed to represent a longitudinal section of a partially mixed estuary that neglects across-channel variation but exhibits salinity driven estuarine circulation. The idealized domain is designed to mimic the primary features of the York River, VA. Suspended load, erosion and deposition are calculated within the sediment transport routines of the COAWST modeling system. We compare different methods for prescribing settling velocity of fine-grained material. The simplest, standard model neglects flocculation dynamics while the complex treatment is a size-class-based flocculation model (FLOCMOD). Differences in tidal and daily averages of suspended load, bulk settling velocity and bed deposition are compared between the standard and FLOCMOD runs, to examine the relative impact of flocculation on sediment transport patterns. We expect FLOCMOD to have greater variability and

  3. Real-time characterization of partially observed epidemics using surrogate models.

    Energy Technology Data Exchange (ETDEWEB)

    Safta, Cosmin; Ray, Jaideep; Lefantzi, Sophia; Crary, David (Applied Research Associates, Arlington, VA); Sargsyan, Khachik; Cheng, Karen (Applied Research Associates, Arlington, VA)

    2011-09-01

    We present a statistical method, predicated on the use of surrogate models, for the 'real-time' characterization of partially observed epidemics. Observations consist of counts of symptomatic patients, diagnosed with the disease, that may be available in the early epoch of an ongoing outbreak. Characterization, in this context, refers to estimation of epidemiological parameters that can be used to provide short-term forecasts of the ongoing epidemic, as well as to provide gross information on the dynamics of the etiologic agent in the affected population e.g., the time-dependent infection rate. The characterization problem is formulated as a Bayesian inverse problem, and epidemiological parameters are estimated as distributions using a Markov chain Monte Carlo (MCMC) method, thus quantifying the uncertainty in the estimates. In some cases, the inverse problem can be computationally expensive, primarily due to the epidemic simulator used inside the inversion algorithm. We present a method, based on replacing the epidemiological model with computationally inexpensive surrogates, that can reduce the computational time to minutes, without a significant loss of accuracy. The surrogates are created by projecting the output of an epidemiological model on a set of polynomial chaos bases; thereafter, computations involving the surrogate model reduce to evaluations of a polynomial. We find that the epidemic characterizations obtained with the surrogate models is very close to that obtained with the original model. We also find that the number of projections required to construct a surrogate model is O(10)-O(10{sup 2}) less than the number of samples required by the MCMC to construct a stationary posterior distribution; thus, depending upon the epidemiological models in question, it may be possible to omit the offline creation and caching of surrogate models, prior to their use in an inverse problem. The technique is demonstrated on synthetic data as well as

  4. Nonlinear dynamic model for visual object tracking on Grassmann manifolds with partial occlusion handling.

    Science.gov (United States)

    Khan, Zulfiqar Hasan; Gu, Irene Yu-Hua

    2013-12-01

    This paper proposes a novel Bayesian online learning and tracking scheme for video objects on Grassmann manifolds. Although manifold visual object tracking is promising, large and fast nonplanar (or out-of-plane) pose changes and long-term partial occlusions of deformable objects in video remain a challenge that limits the tracking performance. The proposed method tackles these problems with the main novelties on: 1) online estimation of object appearances on Grassmann manifolds; 2) optimal criterion-based occlusion handling for online updating of object appearances; 3) a nonlinear dynamic model for both the appearance basis matrix and its velocity; and 4) Bayesian formulations, separately for the tracking process and the online learning process, that are realized by employing two particle filters: one is on the manifold for generating appearance particles and another on the linear space for generating affine box particles. Tracking and online updating are performed in an alternating fashion to mitigate the tracking drift. Experiments using the proposed tracker on videos captured by a single dynamic/static camera have shown robust tracking performance, particularly for scenarios when target objects contain significant nonplanar pose changes and long-term partial occlusions. Comparisons with eight existing state-of-the-art/most relevant manifold/nonmanifold trackers with evaluations have provided further support to the proposed scheme.

  5. A model and variance reduction method for computing statistical outputs of stochastic elliptic partial differential equations

    Science.gov (United States)

    Vidal-Codina, F.; Nguyen, N. C.; Giles, M. B.; Peraire, J.

    2015-09-01

    We present a model and variance reduction method for the fast and reliable computation of statistical outputs of stochastic elliptic partial differential equations. Our method consists of three main ingredients: (1) the hybridizable discontinuous Galerkin (HDG) discretization of elliptic partial differential equations (PDEs), which allows us to obtain high-order accurate solutions of the governing PDE; (2) the reduced basis method for a new HDG discretization of the underlying PDE to enable real-time solution of the parameterized PDE in the presence of stochastic parameters; and (3) a multilevel variance reduction method that exploits the statistical correlation among the different reduced basis approximations and the high-fidelity HDG discretization to accelerate the convergence of the Monte Carlo simulations. The multilevel variance reduction method provides efficient computation of the statistical outputs by shifting most of the computational burden from the high-fidelity HDG approximation to the reduced basis approximations. Furthermore, we develop a posteriori error estimates for our approximations of the statistical outputs. Based on these error estimates, we propose an algorithm for optimally choosing both the dimensions of the reduced basis approximations and the sizes of Monte Carlo samples to achieve a given error tolerance. We provide numerical examples to demonstrate the performance of the proposed method.

  6. A model and variance reduction method for computing statistical outputs of stochastic elliptic partial differential equations

    Energy Technology Data Exchange (ETDEWEB)

    Vidal-Codina, F., E-mail: fvidal@mit.edu [Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Nguyen, N.C., E-mail: cuongng@mit.edu [Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Giles, M.B., E-mail: mike.giles@maths.ox.ac.uk [Mathematical Institute, University of Oxford, Oxford (United Kingdom); Peraire, J., E-mail: peraire@mit.edu [Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States)

    2015-09-15

    We present a model and variance reduction method for the fast and reliable computation of statistical outputs of stochastic elliptic partial differential equations. Our method consists of three main ingredients: (1) the hybridizable discontinuous Galerkin (HDG) discretization of elliptic partial differential equations (PDEs), which allows us to obtain high-order accurate solutions of the governing PDE; (2) the reduced basis method for a new HDG discretization of the underlying PDE to enable real-time solution of the parameterized PDE in the presence of stochastic parameters; and (3) a multilevel variance reduction method that exploits the statistical correlation among the different reduced basis approximations and the high-fidelity HDG discretization to accelerate the convergence of the Monte Carlo simulations. The multilevel variance reduction method provides efficient computation of the statistical outputs by shifting most of the computational burden from the high-fidelity HDG approximation to the reduced basis approximations. Furthermore, we develop a posteriori error estimates for our approximations of the statistical outputs. Based on these error estimates, we propose an algorithm for optimally choosing both the dimensions of the reduced basis approximations and the sizes of Monte Carlo samples to achieve a given error tolerance. We provide numerical examples to demonstrate the performance of the proposed method.

  7. An analytical model of hydrogen evolution and oxidation reactions on electrodes partially covered with a catalyst.

    Science.gov (United States)

    Kemppainen, Erno; Halme, Janne; Lund, Peter D

    2016-05-11

    Our previous theoretical study on the performance limits of the platinum (Pt) nanoparticle catalyst for the hydrogen evolution reaction (HER) had shown that the mass transport losses at a partially catalyst-covered planar electrode are independent of the catalyst loading. This suggests that the two-dimensional (2D) numerical model used could be simplified to a one-dimensional (1D) model to provide an easier but equally accurate description of the operation of these HER electrodes. In this article, we derive an analytical 1D model and show that it indeed gives results that are practically identical to the 2D numerical simulations. We discuss the general principles of the model and how it can be used to extend the applicability of existing electrochemical models of planar electrodes to low catalyst loadings suitable for operating photoelectrochemical devices under unconcentrated sunlight. Since the mass transport losses of the HER are often very sensitive to the H2 concentration, we also discuss the limiting current density of the hydrogen oxidation reaction (HOR) and how it is not necessarily independent of the reaction kinetics. The results give insight into the interplay of kinetic and mass-transport limitations at HER/HOR electrodes with implications for the design of kinetic experiments and the optimization of catalyst loadings in the photoelectrochemical cells.

  8. q-Ising model on a duplex and a partially duplex clique

    CERN Document Server

    Chmiel, Anna; Sznajd-Weron, Katarzyna

    2016-01-01

    We analyze a modified kinetic Ising model, so called $q$- neighbor Ising model, with Metropolis dynamics,[Phys. Rev. E {\\bf92} 052105] on a duplex clique and a partially duplex clique. In the $q$-Ising model each spin interacts only with $q$ spins randomly chosen from the whole neighborhood. In the case of a duplex clique the change of a spin is allowed only if both levels simultaneously induce this change. Due to the mean-field like nature of the model we are able to derive the analytic form of transition probabilities and solve the corresponding master equation. The existence of the second level changes dramatically the character of the phase transition. In the case of the monoplex clique, the $q$-neighbor Ising model exhibits continuous phase transition for $q=3$, discontinuous phase transition for $q \\ge 4$ and for $q=1$ and $q=2$ the phase transition is not observed. On the other hand, in the case of the duplex clique continuous phase transitions are observed for all values of $q$, even for $q=1$ and $q=...

  9. Combining partially ranked data in plant breeding and biology: II. Analysis with Rasch model

    Directory of Open Access Journals (Sweden)

    Ivan Simko

    2010-07-01

    Full Text Available Many years of breeding experiments, germplasm screening, and molecular biologic experimentation have generated volumes of sequence, genotype, and phenotype information that have been stored in public data repositories. These resources afford genetic and genomic researchers the opportunity to handle and analyze raw data from multiple laboratories and study groups whose research interests revolve around a common or closely related trait. However, although such data sets are widely available for secondary analysis, their heterogeneous nature often precludes their direct combination and joint exploration. Integration of phenotype information across multiple studies and databases is challenging due to variations in the measurement instruments, endpoint classifications, and biological material employed by each investigator. In the present work, we demonstrate how Rasch measurement model can surmount these problems. The model allows incorporating data sets with partially overlapping variables, large numbers of missing data points and dissimilar ratings of phenotypic endpoints. The model also enables quantifying the extent of heterogeneity between data sets. Biologists can use the model in a data-mining process to obtain combined ratings from various databases and other sources. Subsequently, these ratings can be used for selecting desirable material or (in combination with genotypic information for mapping genes involved in the particular trait. The model is not limited to genetics and breeding and can be applied in many other areas of biology and agriculture.

  10. Ionic screening of charged impurities in electrolytically gated graphene: A partially linearized Poisson-Boltzmann model.

    Science.gov (United States)

    Sharma, P; Mišković, Z L

    2015-10-07

    We present a model describing the electrostatic interactions across a structure that consists of a single layer of graphene with large area, lying above an oxide substrate of finite thickness, with its surface exposed to a thick layer of liquid electrolyte containing salt ions. Our goal is to analyze the co-operative screening of the potential fluctuation in a doped graphene due to randomness in the positions of fixed charged impurities in the oxide by the charge carriers in graphene and by the mobile ions in the diffuse layer of the electrolyte. In order to account for a possibly large potential drop in the diffuse later that may arise in an electrolytically gated graphene, we use a partially linearized Poisson-Boltzmann (PB) model of the electrolyte, in which we solve a fully nonlinear PB equation for the surface average of the potential in one dimension, whereas the lateral fluctuations of the potential in graphene are tackled by linearizing the PB equation about the average potential. In this way, we are able to describe the regime of equilibrium doping of graphene to large densities for arbitrary values of the ion concentration without restrictions to the potential drop in the electrolyte. We evaluate the electrostatic Green's function for the partially linearized PB model, which is used to express the screening contributions of the graphene layer and the nearby electrolyte by means of an effective dielectric function. We find that, while the screened potential of a single charged impurity at large in-graphene distances exhibits a strong dependence on the ion concentration in the electrolyte and on the doping density in graphene, in the case of a spatially correlated two-dimensional ensemble of impurities, this dependence is largely suppressed in the autocovariance of the fluctuating potential.

  11. Establishment of a rhesus monkey model of middle cerebral artery ischemia and reperfusion using a microcatheter embolization method

    Institute of Scientific and Technical Information of China (English)

    Jie Yang; Xiaoqi Huang; Hongxia Li; Li Wang; Jingqiu Cheng; Jian Guo; Hongbo Zheng; Muke Zhou; Li He; Wenying Cao; Li Xiao; Jiachuan Duan; Qiyong Gong

    2010-01-01

    Nonhuman primates are closest to humans in terms of lineage,and middle cerebral artery ischemia/reperfusion responses of nonhuman primates are most similar to ischemic stroke in humans.Therefore,nonhuman primates could be utilized to simulate the process of ischemic stroke in the human.Few studies,however,have reported the use of endovascular technology to establish a rhesus monkey stroke model.In the present study,seven adult,male,rhesus monkeys were selected and,following anesthesia,a microcatheter was inserted into one side of the middle cerebral artery via the femoral artery to block blood flow,thereby resulting in middle cerebral artery occlusion.After 2 hours,the microcatheter was withdrawn to restore the middle cerebral artery blood flow and to establish ischemia/reperfusion.Results from angiography and magnetic resonance angiography confirmed occlusion and reopening of the middle cerebral artery.Magnetic resonance imaging revealed the existence of ischemic brain lesions,and neurological examination showed sustained functional deficits following surgery.The rhesus monkey middle cerebral artery ischemia/reperfusion models established by microcatheter embolization had the advantage of non—craniotomy invasion and reproducibility.The scope and degree of ischemic damage using this model was controllable.Therefore,this nonhuman primate model is an ideal model for cerebral ischemia and reperfusion.

  12. Rapid 3D dynamic arterial spin labeling with a sparse model-based image reconstruction.

    Science.gov (United States)

    Zhao, Li; Fielden, Samuel W; Feng, Xue; Wintermark, Max; Mugler, John P; Meyer, Craig H

    2015-11-01

    Dynamic arterial spin labeling (ASL) MRI measures the perfusion bolus at multiple observation times and yields accurate estimates of cerebral blood flow in the presence of variations in arterial transit time. ASL has intrinsically low signal-to-noise ratio (SNR) and is sensitive to motion, so that extensive signal averaging is typically required, leading to long scan times for dynamic ASL. The goal of this study was to develop an accelerated dynamic ASL method with improved SNR and robustness to motion using a model-based image reconstruction that exploits the inherent sparsity of dynamic ASL data. The first component of this method is a single-shot 3D turbo spin echo spiral pulse sequence accelerated using a combination of parallel imaging and compressed sensing. This pulse sequence was then incorporated into a dynamic pseudo continuous ASL acquisition acquired at multiple observation times, and the resulting images were jointly reconstructed enforcing a model of potential perfusion time courses. Performance of the technique was verified using a numerical phantom and it was validated on normal volunteers on a 3-Tesla scanner. In simulation, a spatial sparsity constraint improved SNR and reduced estimation errors. Combined with a model-based sparsity constraint, the proposed method further improved SNR, reduced estimation error and suppressed motion artifacts. Experimentally, the proposed method resulted in significant improvements, with scan times as short as 20s per time point. These results suggest that the model-based image reconstruction enables rapid dynamic ASL with improved accuracy and robustness.

  13. Numerical study of spatial-temporal evolution of the secondary flow in the models of a common carotid artery

    Directory of Open Access Journals (Sweden)

    Yakov A. Gataulin

    2017-03-01

    Full Text Available A numerical study of the secondary flow in two geometrically different models of a common carotid artery has been carried out. One of the models (Model 1 is characterized by a statistically averaged curvature, and the second one (Model 2 is attributed to the maximal curvature of the artery. It was shown that the most intensive swirl occurred at the phase of flow rate decreasing, the maximum values of the swirl parameters were observed at the interface of the cervical and thoracic segments of the artery. This interface is the place where the Dean vortices are transformed into a single vortex forming a swirling flow. The swirl intensity averaged over the systole and characterized by the ratio of the maximal values of the axial and circumferential velocities was evaluated as 0.20 for Model 1 and 0.25 for Model 2. Generally, it was in accordance with the data of clinical measurements.

  14. Modeling of thermally driven hydrological processes in partially saturated fractured rock

    Energy Technology Data Exchange (ETDEWEB)

    Tsang, Yvonne; Birkholzer, Jens; Mukhopadhyay, Sumit

    2009-03-15

    This paper is a review of the research that led to an in-depth understanding of flow and transport processes under strong heat stimulation in fractured, porous rock. It first describes the anticipated multiple processes that come into play in a partially saturated, fractured porous volcanic tuff geological formation, when it is subject to a heat source such as that originating from the decay of radionuclides. The rationale is then given for numerical modeling being a key element in the study of multiple processes that are coupled. The paper outlines how the conceptualization and the numerical modeling of the problem evolved, progressing from the simplified to the more realistic. Examples of numerical models are presented so as to illustrate the advancement and maturation of the research over the last two decades. The most recent model applied to in situ field thermal tests is characterized by (1) incorporation of a full set of thermal-hydrological processes into a numerical simulator, (2) realistic representation of the field test geometry, in three dimensions, and (3) use of site-specific characterization data for model inputs. Model predictions were carried out prior to initiation of data collection, and the model results were compared to diverse sets of measurements. The approach of close integration between modeling and field measurements has yielded a better understanding of how coupled thermal hydrological processes produce redistribution of moisture within the rock, which affects local permeability values and subsequently the flow of liquid and gases. The fluid flow in turn will change the temperature field. We end with a note on future research opportunities, specifically those incorporating chemical, mechanical, and microbiological factors into the study of thermal and hydrological processes.

  15. Pilot Study of the Efficacy of Extracellular Matrix Arterial Interposition Grafts in a Sheep (Ovis aries) Model

    Science.gov (United States)

    2014-02-18

    extracellular matrix arterial interposition grafts in a sheep (Ovis aries) model." 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...carotid arteries in sheep . Methods: Three crossbred sheep were anesthetized, instrumented, and had 10 cm interposition grafts placed in both carotid... surgery , two animals had uncomplicated courses without clinical evidence of thrombosis or wound complication. The third animal succumbed from graft failure

  16. Globally COnstrained Local Function Approximation via Hierarchical Modelling, a Framework for System Modelling under Partial Information

    DEFF Research Database (Denmark)

    Øjelund, Henrik; Sadegh, Payman

    2000-01-01

    , constraints are introduced to ensure the conformity of the estimates to a gien global structure. Hierarchical models are then utilized as a tool to ccomodate global model uncertainties via parametric variabilities within the structure. The global parameters and their associated uncertainties are estimated...... simultaneously with the (local estimates of) function values. The approach is applied to modelling of a linear time variant dynamic system under prior linear time invariant structure where local regression fails as a result of high dimensionality.......Local function approximations concern fitting low order models to weighted data in neighbourhoods of the points where the approximations are desired. Despite their generality and convenience of use, local models typically suffer, among others, from difficulties arising in physical interpretation...

  17. A simple model of cerebral blood flow dependence on arterial blood pressure

    CERN Document Server

    Gersten, Alexander

    2011-01-01

    It is shown that the dependence of the cerebral blood flow (CBF) on mean arterial blood pressure (MABP) can be described with a simple model having the following assumptions. Below certain MABP (denoted as MABP1) there are no autoregulatory or feedback mechanisms influencing CBF. Between MABP1 and MABP2 (MABP at which breakthrough accurs) there is a linear (on MABP) dependent feedback with a sloap depending very much on the individual considered. The classical autoregulation model with a plateau in between MABP1 and MABP2 is a particular case of this model. The model describes well the experiments performed on dogs (Harper 1966), for which the individual feedback sloap parameter varied to great extent, indicating the importance of mesurments on individuals against averaged mesurments (or measurments on diffent individuals) which superficially support the classical autoregulation. New effect of decreased CBF, while increasing MABP, was observed.

  18. The analysis of MHD blood flows through porous arteries using a locally modified homogenous nanofluids model.

    Science.gov (United States)

    Akbarzadeh, Pooria

    2016-05-12

    In this paper, magneto-hydrodynamic blood flows through porous arteries are numerically simulated using a locally modified homogenous nanofluids model. Blood is taken into account as the third-grade non-Newtonian fluid containing nanoparticles. In the modified nanofluids model, the viscosity, density, and thermal conductivity of the solid-liquid mixture (nanofluids) which are commonly utilized as an effective value, are locally combined with the prevalent single-phase model. The modified governing equations are solved numerically using Newton's method and a block tridiagonal matrix solver. The results are compared to the prevalent nanofluids single-phase model. In addition, the efficacies of important physical parameters such as pressure gradient, Brownian motion parameter, thermophoresis parameter, magnetic-field parameter, porosity parameter, and etc. on temperature, velocity and nanoparticles concentration profiles are examined.

  19. A PARTIALLY-AVERAGED NAVIER-STOKES MODEL FOR HILL AND CURVED DUCT FLOW

    Institute of Scientific and Technical Information of China (English)

    MA Jia-mei; WANG Fu-jun; YU Xin; LIU Zhu-qing

    2011-01-01

    Turbulent flows past hill and curved ducts exist in many engineering applications.Simulations of the turbulent flow are carried out based on a newly developed technique,the Partially-Averaged Navier-Stokes(PANS)model,including separation,recirculation,reattachment,turbulent vortex mechanism.The focus is on how to accurately predict typical separating,reattaching and secondary motion at a reasonable computational expense.The effect of the parameter,the unresolved-to-total ratio of kinetic energy (fk),is examined with a given unresolved-to-total ratio of dissipation(fε)for the hill flow with a much coarser grid system than required by the LES.An optimal value of fk can be obtained to predict the separation and reattachment locations and for more accurate simulation of the resolved turbulence.In addition,the turbulent secondary motions are captured by a smaller fk as compared with the RANS method with the same grid.

  20. Geochemistry of polymict ureilite EET83309, and a partially-disruptive impact model for ureilite origin

    Science.gov (United States)

    Warren, Paul H.; Kallemeyn, Gregory W.

    1989-01-01

    Bulk-compositional data for the EET83309 polymict ureilite were obtained using INAA and radiochemistry procedures and electron probe analysis. It was found that the EET83309 has a bulk composition indistinguishable from ordinary ('monomict') ureilites for all elements except light-middle REEs (which are present in much higher concentrations), suggesting that polymict ureilites are mixtures of ordinary ureilites which were mixed on a very small number of parent bodies. Despite the light-REE enrichments, polymict ureilites are nearly devoid of basaltic (Al-rich) material. It is suggested that the missing basalt may have been blown off the parent body by a partially disruptive collision with a large C-rich projectile. This impact model of ureilite origin reconciles many paradoxical aspects of ureilite composition.

  1. Variation of incoming solar radiation flux during a partial eclipse episode: an improved model simulation

    CERN Document Server

    Petkov, Boyan; Vitale, Vito; Lanconelli, Christian; Mazzola, Mauro

    2011-01-01

    Model simulations of solar irradiance reaching the Earth's surface during a solar eclipse constitute a useful tool for studying the impact of this phenomenon on the radiance propagation through the atmosphere. A simple approach to extend the use of an algorithm already adopted for evaluating the variations in the extraterrestrial solar radiation during a total eclipse is proposed for a partial eclipse case. The application is based on the assessment of the distance between the apparent solar and lunar disk centers on the celestial hemisphere, using the local circumstances and the ratio between the Sun and Moon radii as input parameters. It was found that during the eclipse of March 29, 2006, the present approach led to an estimate of the surface UV solar irradiance trend differing by no more than \\pm5% from the corresponding trend observed at Bologna (Italy).

  2. Partial continuation model and its application in mitigating systematic errors of double-differenced GPS measurements

    Institute of Scientific and Technical Information of China (English)

    GUO Jianfeng; OU Jikun; REN Chao

    2005-01-01

    Based on the so-called partial continuation model with exact finite measurements, a new stochastic assessment procedure is introduced. For every satellite pair, the temporal correlation coefficient is estimated using the original double-differenced (DD) GPS measurements. And then, the Durbin-Watson test is applied to test specific hypothesis on the temporal correlation coefficient. Unless the test is not significant with a certain significant level, a data transformation is required. These transformed measurements are free of time correlations. For purpose of illustration, two static GPS baseline data sets are analyzed in detail. The experimental results demonstrate that the proposed procedure can mitigate effectively the impact of systematic errors on DD GPS measurements.

  3. Asymptotics of Huber-Dutter Estimators for Partial Linear Model with Nonstochastic Designs

    Institute of Scientific and Technical Information of China (English)

    Xing-wei Tong; Heng-jian Cui; Hui Zhao

    2005-01-01

    For partial linear model Y = Xτ0 + g0(T) + e with unknown β0 ∈ Rd and an unknown smooth function go, this paper considers the Huber-Dutter estimators ofβ0, scale σ for the errors and the function go respectively, in which the smoothing B-spline function is used. Under some regular conditions, it is shown that the Huber-Dutter estimators of β0 and σ are asymptotically normal with convergence rate n-1/2 and the B-spline Huber-Dutter estimator of g0 achieves the optimal convergence rate in nonparametric regression.A simulation study demonstrates that the Huber-Dutter estimator ofβ0 is competitive with its M-estimator without scale parameter and the ordinary least square estimator. An example is presented after the simulation study.

  4. Consistency and normality of Huber-Dutter estimators for partial linear model

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    For partial linear model Y = Xτβ0 + g0(T) + with unknown β0 ∈ Rd and an unknown smooth function g0, this paper considers the Huber-Dutter estimators of β0, scale σ for the errors and the function g0 approximated by the smoothing B-spline functions, respectively. Under some regularity conditions, the Huber-Dutter estimators of β0 and σ are shown to be asymptotically normal with the rate of convergence n-1/2 and the B-spline Huber-Dutter estimator of g0 achieves the optimal rate of convergence in nonparametric regression. A simulation study and two examples demonstrate that the Huber-Dutter estimator of β0 is competitive with its M-estimator without scale parameter and the ordinary least square estimator.

  5. CMS Partial Releases Model, Tools, and Applications. Online and Framework-Light Releases

    CERN Document Server

    Jones, Christopher D; Meschi, Emilio; Shahzad Muzaffar; Andreas Pfeiffer; Ratnikova, Natalia; Sexton-Kennedy, Elizabeth

    2009-01-01

    The CMS Software project CMSSW embraces more than a thousand packages organized in subsystems for analysis, event display, reconstruction, simulation, detector description, data formats, framework, utilities and tools. The release integration process is highly automated by using tools developed or adopted by CMS. Packaging in rpm format is a built-in step in the software build process. For several well-defined applications it is highly desirable to have only a subset of the CMSSW full package bundle. For example, High Level Trigger algorithms that run on the Online farm, and need to be rebuilt in a special way, require no simulation, event display, or analysis packages. Physics analysis applications in Root environment require only a few core libraries and the description of CMS specific data formats. We present a model of CMS Partial Releases, used for preparation of the customized CMS software builds, including description of the tools used, the implementation, and how we deal with technical challenges, suc...

  6. Consistency and normality of Huber-Dutter estimators for partial linear model

    Institute of Scientific and Technical Information of China (English)

    TONG XingWei; CUI HengJian; YU Peng

    2008-01-01

    For partial linear model Y = Xτβ0 + g0(T) + ∈ with unknown/β0 ∈ Rd and an unknown smooth function g0,this paper considers the Huber-Dutter estimators of/β0,scale σ for the errors and the function g0 approximated by the smoothing B-spline functions,respectively.Under some regularity conditions,the Huber-Dutter estimators of/β0 and σ are shown to be asymptotically normal with the rate of convergence n-1/2 and the B-spline Huber-Dutter estimator of go achieves the optimal rate of convergence in nonparametric regression.A simulation study and two examples demonstrate that the Huber-Dutter estimator of/β0 is competitive with its M-estimator without scale parameter and the ordinary least square estimator.

  7. What You Don't Know Can Hurt You: Missing Data and Partial Credit Model Estimates.

    Science.gov (United States)

    Thomas, Sarah L; Schmidt, Karen M; Erbacher, Monica K; Bergeman, Cindy S

    2016-01-01

    The authors investigated the effect of missing completely at random (MCAR) item responses on partial credit model (PCM) parameter estimates in a longitudinal study of Positive Affect. Participants were 307 adults from the older cohort of the Notre Dame Study of Health and Well-Being (Bergeman and Deboeck, 2014) who completed questionnaires including Positive Affect items for 56 days. Additional missing responses were introduced to the data, randomly replacing 20%, 50%, and 70% of the responses on each item and each day with missing values, in addition to the existing missing data. Results indicated that item locations and person trait level measures diverged from the original estimates as the level of degradation from induced missing data increased. In addition, standard errors of these estimates increased with the level of degradation. Thus, MCAR data does damage the quality and precision of PCM estimates.

  8. New Inference Procedures for Semiparametric Varying-Coefficient Partially Linear Cox Models

    Directory of Open Access Journals (Sweden)

    Yunbei Ma

    2014-01-01

    Full Text Available In biomedical research, one major objective is to identify risk factors and study their risk impacts, as this identification can help clinicians to both properly make a decision and increase efficiency of treatments and resource allocation. A two-step penalized-based procedure is proposed to select linear regression coefficients for linear components and to identify significant nonparametric varying-coefficient functions for semiparametric varying-coefficient partially linear Cox models. It is shown that the penalized-based resulting estimators of the linear regression coefficients are asymptotically normal and have oracle properties, and the resulting estimators of the varying-coefficient functions have optimal convergence rates. A simulation study and an empirical example are presented for illustration.

  9. A multiscale model for analyzing the synergy of CS and WSS on the endothelium in straight arteries

    Institute of Scientific and Technical Information of China (English)

    Kairong Qin; Zonglai Jiang; Hui Sun; Keqin Gong; Zhaorong Liu

    2006-01-01

    A multiscale model was proposed to calculate the circumferential stress (CS) and wall shear stress (WSS) and analyze the effects of global and local factors on the CS,WSS and their synergy on the arterial endothelium in large straight arteries.A parameter pair [Zs,SPA] (defined as the ratio of CS amplitude to WSS amplitude and the phase angle between CS and WSS for different harmonic components,respectively) was proposed to characterize the synergy of CS and WSS.The results demonstrated that the CS Or WSS in the large straight arteries iS determined bv the global factors,i.e.the preloads and the aflerloads,and the local factors,i.e.the local mechanical properties and the zero-stress states of arterial walls,whereas the Zs and S P A are primarily determined by the local factors and the arerloads.Because the arterial input impedance has been shown to reflect the physiological and pathological states of whole downstream arterial beds,the stress amplitude ratio ZS and the stress phase difierence S P A might be appropriate indices to reflect the influences Of the states of whole downstream arterial beds on the local blood flow-dependent phenomena such as angiogenesis,vascular remodeling and atherosgenesis.

  10. In-out intermittency in partial differential equation and ordinary differential equation models.

    Science.gov (United States)

    Covas, Eurico; Tavakol, Reza; Ashwin, Peter; Tworkowski, Andrew; Brooke, John M.

    2001-06-01

    We find concrete evidence for a recently discovered form of intermittency, referred to as in-out intermittency, in both partial differential equation (PDE) and ordinary differential equation (ODE) models of mean field dynamos. This type of intermittency [introduced in P. Ashwin, E. Covas, and R. Tavakol, Nonlinearity 9, 563 (1999)] occurs in systems with invariant submanifolds and, as opposed to on-off intermittency which can also occur in skew product systems, it requires an absence of skew product structure. By this we mean that the dynamics on the attractor intermittent to the invariant manifold cannot be expressed simply as the dynamics on the invariant subspace forcing the transverse dynamics; the transverse dynamics will alter that tangential to the invariant subspace when one is far enough away from the invariant manifold. Since general systems with invariant submanifolds are not likely to have skew product structure, this type of behavior may be of physical relevance in a variety of dynamical settings. The models employed here to demonstrate in-out intermittency are axisymmetric mean-field dynamo models which are often used to study the observed large-scale magnetic variability in the Sun and solar-type stars. The occurrence of this type of intermittency in such models may be of interest in understanding some aspects of such variabilities. (c) 2001 American Institute of Physics.

  11. Partial redistribution in 3D non-LTE radiative transfer in solar atmosphere models

    CERN Document Server

    Sukhorukov, Andrii V

    2016-01-01

    Resonance spectral lines such as H I Ly {\\alpha}, Mg II h&k, and Ca II H&K that form in the solar chromosphere are influenced by the effects of 3D radiative transfer as well as partial redistribution (PRD). So far no one has modeled these lines including both effects simultaneously owing to the high computing demands of existing algorithms. Such modeling is however indispensable for accurate diagnostics of the chromosphere. We present a computationally tractable method to treat PRD scattering in 3D model atmospheres using a 3D non-LTE radiative transfer code. To make the method memory-friendly, we use the hybrid approximation of Leenaarts et al. (2012) for the redistribution integral. To make it fast, we use linear interpolation on equidistant frequency grids. We verify our algorithm against computations with the RH code and analyze it for stability, convergence, and usefulness of acceleration using model atoms of Mg II with the h&k lines and H I with the Ly {\\alpha} line treated in PRD. A typical...

  12. Research on Odor Interaction between Aldehyde Compounds via a Partial Differential Equation (PDE Model

    Directory of Open Access Journals (Sweden)

    LuchunYan

    2015-01-01

    Full Text Available In order to explore the odor interaction of binary odor mixtures, a series of odor intensity evaluation tests were performed using both individual components and binary mixtures of aldehydes. Based on the linear relation between the logarithm of odor activity value and odor intensity of individual substances, the relationship between concentrations of individual constituents and their joint odor intensity was investigated by employing a partial differential equation (PDE model. The obtained results showed that the binary odor interaction was mainly influenced by the mixing ratio of two constituents, but not the concentration level of an odor sample. Besides, an extended PDE model was also proposed on the basis of the above experiments. Through a series of odor intensity matching tests for several different binary odor mixtures, the extended PDE model was proved effective at odor intensity prediction. Furthermore, odorants of the same chemical group and similar odor type exhibited similar characteristics in the binary odor interaction. The overall results suggested that the PDE model is a more interpretable way of demonstrating the odor interactions of binary odor mixtures.

  13. Partial ionization in dense plasmas: Comparisons among average-atom density functional models

    Science.gov (United States)

    Murillo, Michael S.; Weisheit, Jon; Hansen, Stephanie B.; Dharma-wardana, M. W. C.

    2013-06-01

    Nuclei interacting with electrons in dense plasmas acquire electronic bound states, modify continuum states, generate resonances and hopping electron states, and generate short-range ionic order. The mean ionization state (MIS), i.e, the mean charge Z of an average ion in such plasmas, is a valuable concept: Pseudopotentials, pair-distribution functions, equations of state, transport properties, energy-relaxation rates, opacity, radiative processes, etc., can all be formulated using the MIS of the plasma more concisely than with an all-electron description. However, the MIS does not have a unique definition and is used and defined differently in different statistical models of plasmas. Here, using the MIS formulations of several average-atom models based on density functional theory, we compare numerical results for Be, Al, and Cu plasmas for conditions inclusive of incomplete atomic ionization and partial electron degeneracy. By contrasting modern orbital-based models with orbital-free Thomas-Fermi models, we quantify the effects of shell structure, continuum resonances, the role of exchange and correlation, and the effects of different choices of the fundamental cell and boundary conditions. Finally, the role of the MIS in plasma applications is illustrated in the context of x-ray Thomson scattering in warm dense matter.

  14. Partial ionization in dense plasmas: comparisons among average-atom density functional models.

    Science.gov (United States)

    Murillo, Michael S; Weisheit, Jon; Hansen, Stephanie B; Dharma-wardana, M W C

    2013-06-01

    Nuclei interacting with electrons in dense plasmas acquire electronic bound states, modify continuum states, generate resonances and hopping electron states, and generate short-range ionic order. The mean ionization state (MIS), i.e, the mean charge Z of an average ion in such plasmas, is a valuable concept: Pseudopotentials, pair-distribution functions, equations of state, transport properties, energy-relaxation rates, opacity, radiative processes, etc., can all be formulated using the MIS of the plasma more concisely than with an all-electron description. However, the MIS does not have a unique definition and is used and defined differently in different statistical models of plasmas. Here, using the MIS formulations of several average-atom models based on density functional theory, we compare numerical results for Be, Al, and Cu plasmas for conditions inclusive of incomplete atomic ionization and partial electron degeneracy. By contrasting modern orbital-based models with orbital-free Thomas-Fermi models, we quantify the effects of shell structure, continuum resonances, the role of exchange and correlation, and the effects of different choices of the fundamental cell and boundary conditions. Finally, the role of the MIS in plasma applications is illustrated in the context of x-ray Thomson scattering in warm dense matter.

  15. Order and excitation in partially Gutzwiller projected t-t'-t"-J-U models.

    Science.gov (United States)

    Voo, Khee-Kyun

    2011-12-14

    Extended t-t'-t"-J-U models in which the second-nearest-neighbor hopping (t') and third-nearest-neighbor hopping (t") are included are studied using renormalized mean field theory. The models are meant to be low-energy effective models for the Hubbard models, and hence the Heisenberg exchange integral J and Hubbard repulsion U are related by J = 4t(2)/U. The trial wavefunctions for the ground states are partially Gutzwiller projected Hartree-Fock states. The Gutzwiller projection is implemented by means of a Gutzwiller approximation, and the site double occupancy d is taken as a variational parameter. It is found that a large |t'/t| narrows the band filling range that sustains antiferromagnetism (AFM) in the ground state, enhances the d-wave singlet superconductivity (dSC) in hole overdoped systems, but suppresses the dSC in electron overdoped systems. For a system that has large |t'/t| and |t"/t'|, the superconductivity (SC) at the onset of AFM in hole doped band filling is strongly suppressed. On the excitation occurring, when an electron doped system simultaneously contains SC and AFM, the system is found to have a nodeless gap at the Fermi level. Finally, the result of this study is related to experiments on the superconducting cuprates.

  16. A Decentralized Partially Observable Decision Model for Recognizing the Multiagent Goal in Simulation Systems

    Directory of Open Access Journals (Sweden)

    Shiguang Yue

    2016-01-01

    Full Text Available Multiagent goal recognition is important in many simulation systems. Many of the existing modeling methods need detailed domain knowledge of agents’ cooperative behaviors and a training dataset to estimate policies. To solve these problems, we propose a novel decentralized partially observable decision model (Dec-POMDM, which models cooperative behaviors by joint policies. In this compact way, we only focus on the distribution of joint policies. Additionally, a model-free algorithm, cooperative colearning based on Sarsa, is exploited to estimate agents’ policies under the assumption of rationality, which makes the training dataset unnecessary. In the inference, considering that the Dec-POMDM is discrete and its state space is large, we implement a marginal filter (MF under the framework of the Dec-POMDM, where the initial world states and results of actions are uncertain. In the experiments, a new scenario is designed based on the standard predator-prey problem: we increase the number of preys, and our aim is to recognize the real target of predators. Experiment results show that (a our method recognizes goals well even when they change dynamically; (b the Dec-POMDM outperforms supervised trained HMMs in terms of precision, recall, and F-measure; and (c the MF infers goals more efficiently than the particle filter under the framework of the Dec-POMDM.

  17. Partial Mass Degenerated Model and Spontaneous CP Violation in the Leptonic Sector

    CERN Document Server

    Ishida, Hiroyuki

    2013-01-01

    We have investigated a flavour model [1] which inspired by small squared-mass difference measured in solar neutrino oscillation experiments and observability in neutrinoless double beta decay experiments. In our model, the $1^{\\rm st.}$ and $2^{\\rm nd.}$ generations of fermions have a common mass at the leading order. Such limit may be a good starting point from the points of view of understanding the mixing patterns and mass spectra. In this limit, the mass matrices are respected an $O (2)$ symmetry on flavor space of the first two generations. For simplicity, we propose a model for lepton sector based on the $D_N$ group which is a discrete subgroup of $O (2)$. We show that our model can reproduce the experimental data without hierarchical couplings except for $5 \\mathchar`- 10%$ tuning partially for the large neutrino mixing. Further, we show a novel relation between the tiny electron mass and the relatively large $\\theta_{13}^{\\rm PMNS}$ via CP violation by the complex vacuum expectation values of the extr...

  18. Partial Wave Analysis in Friedrichs Model With Self-interacting Continua

    CERN Document Server

    Xiao, Zhiguang

    2016-01-01

    We consider the model of coupling bare discrete states with continuum states in which the continuum states can have interactions among themselves. In both nonrelativistic and relativistic cases, by partial-wave decomposition and constraint to the conserved angular momentum eigenstates, the model can be reduced to the same Friedrichs-like model with interactions between continua. If a kind of factorizable form factor is chosen, the model can be exactly solvable, that is, the generalized discrete eigenstates including bound states, virtual states and resonances, and the in-state and out-state can all be represented using the original bare states. The exact $S$ matrix is thus obtained. We then discuss the behaviors of the dynamically generated $S$-wave and $P$-wave discrete states as the coupling is varying when there is only one self-interacting bare continuum state. We find that even when the potential is repulsive there could also be resonances and virtual states. In the $P$-wave cases when the interaction is...

  19. Influence of anatomical dominance and hypertension on coronary conduit arterial and microcirculatory flow patterns: a multiscale modeling study.

    Science.gov (United States)

    Mynard, Jonathan P; Smolich, Joseph J

    2016-07-01

    Coronary hemodynamics are known to be affected by intravascular and extravascular factors that vary regionally and transmurally between the perfusion territories of left and right coronary arteries. However, despite clinical evidence that left coronary arterial dominance portends greater cardiovascular risk, relatively little is known about the effects of left or right dominance on regional conduit arterial and microcirculatory blood flow patterns, particularly in the presence of systemic or pulmonary hypertension. We addressed this issue using a multiscale numerical model of the human coronary circulation situated in a closed-loop cardiovascular model. The coronary model represented left or right dominant anatomies and accounted for transmural and regional differences in vascular properties and extravascular compression. Regional coronary flow dynamics of the two anatomical variants were compared under normotensive conditions, raised systemic or pulmonary pressures with maintained flow demand, and after accounting for adaptations known to occur in acute and chronic hypertensive states. Key findings were that 1) right coronary arterial flow patterns were strongly influenced by dominance and systemic/pulmonary hypertension; 2) dominance had minor effects on left coronary arterial and all microvascular flow patterns (aside from mean circumflex flow); 3) although systemic hypertension favorably increased perfusion pressure, this benefit varied regionally and transmurally and was offset by increased left ventricular and septal flow demands; and 4) pulmonary hypertension had a substantial negative effect on right ventricular and septal flows, which was exacerbated by greater metabolic demands. These findings highlight the importance of interactions between coronary arterial dominance and hypertension in modulating coronary hemodynamics.

  20. An optimized animal model for partial and total skin thickness burns studies.

    Science.gov (United States)

    Campelo, Ana Paula Bomfim Soares; Campelo, Marcio Wilker Soares; Britto, Gerly Anne de Castro; Ayala, Alejandro Pedro; Guimarães, Sergio Botelho; Vasconcelos, Paulo Roberto Leitão de

    2011-01-01

    Development of an improved animal model for studying skin burns in rats. Twenty-four male Wistar rats were randomly assigned to four groups (n=6): G1-Control, G2- T100°C, G3-T150°C and G4-T200°C. Two 10 x 10 mm squares were outlined with a sterile surgical marker on each side and along the vertebral column using a prepared template positioned between the anterior and posterior limbs. G2-G4 rats were subjected to 100°C, 150°C and 200ºC thermal burns, respectively. G1 rats served as controls. Burns were inflicted by applying a copper plate connected to an electronic temperature controlling device to the dorsal skin of anesthetized rats. Four burns were produced on each animal (total area: 4 cm²/animal) leaving about 1 cm of undamaged skin between burn areas. Analgesia was administered during 24 h after burn injury by adding 30 mg codeine phosphate hemihydrate to 500 ml tap water. The application of 100°C and 150ºC resulted in partial thickness skin burns with central reepithelialization of the burned area only at 100°C. In G4 group the whole thickness of the skin was injured without central reepithelialization. However, there was marginal reepithelialization in all groups. The model studied is inexpensive and easily reproducible, enabling the achievement of controlled burns with partial or total impairment of the skin in experimental animals.

  1. Cost-effectiveness modelling of percutaneous coronary interventions in stable coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    Ariel; Beresniak; Thibaut; Caruba; Brigitte; Sabatier; Yves; Juillière; Olivier; Dubourg; Nicolas; Danchin

    2015-01-01

    The objective of this study is to develop a cost-effectiveness model comparing drug eluting stents(DES) vs bare metal stent(BMS) in patients suffering of stable coronary artery disease. Using a 2-years time horizon, two simulation models have been developed: BMS first line strategy and DES first line strategy. Direct medical costs were estimated considering ambulatory and hospital costs. The effectiveness endpoint was defined as treatment success, which is the absence of major adverse cardiac events. Probabilistic sensitivity analyses were carried out using 10000 Monte-Carlo simulations. DES appeared slightly more efficacious over 2 years(60% of success) when compared to BMS(58% of success). Total costs over 2 years were estimated at 9303  for the DES and at 8926  for bare metal stent. Hence, corresponding mean cost-effectiveness ratios showed slightly lower costs(P < 0.05) per success for the BMS strategy(15520 /success), as compared to the DES strategy(15588 /success). Incremental costeffectiveness ratio is 18850  for one additional percent of success. The sequential strategy including BMS as the first option appears to be slightly less efficacious but more cost-effective compared to the strategy including DES as first option. Future modelling approaches should confirm these results as further comparative data in stable coronary artery disease and long-term evidence become available.

  2. Gene Expression Profiling of Pulmonary Artery in a Rabbit Model of Pulmonary Thromboembolism

    Science.gov (United States)

    Huang, Jianfei; Zhou, Xiaoyu; Xie, Hao; Zhu, Qilin; Huang, Minjie

    2016-01-01

    Acute pulmonary thromboembolism (PTE) refers to the obstruction of thrombus in pulmonary artery or its branches. Recent studies have suggested that PTE-induced endothelium injury is the major physiological consequence of PTE. And it is reasonal to use PTE-induced endothelium injury to stratify disease severity. According to the massive morphologic and histologic findings, rabbit models could be applied to closely mimic the human PE. Genomewide gene expression profiling has not been attempted in PTE. In this study, we determined the accuracy of rabbit autologous thrombus PTE model for human PTE disease, then we applied gene expression array to identify gene expression changes in pulmonary arteries under PTE to identify potential molecular biomarkers and signaling pathways for PTE. We detected 1343 genes were upregulated and 923 genes were downregulated in PTE rabbits. The expression of several genes (IL-8, TNF-α, and CXCL5) with functional importance were further confirmed in transcript and protein levels. The most significantly differentially regulated genes were related to inflammation, immune disease, pulmonary disease, and cardiovascular diseases. Totally 87 genes were up-regulated in the inflammatory genes. We conclude that gene expression profiling in rabbit PTE model could extend the understanding of PTE pathogenesis at the molecular level. Our study provides the fundamental framework for future clinical research on human PTE, including identification of potential biomarkers for prognosis or therapeutic targets for PTE. PMID:27798647

  3. Gene Expression Profiling of Pulmonary Artery in a Rabbit Model of Pulmonary Thromboembolism.

    Science.gov (United States)

    Tang, Zhiyuan; Wang, Xudong; Huang, Jianfei; Zhou, Xiaoyu; Xie, Hao; Zhu, Qilin; Huang, Minjie; Ni, Songshi

    2016-01-01

    Acute pulmonary thromboembolism (PTE) refers to the obstruction of thrombus in pulmonary artery or its branches. Recent studies have suggested that PTE-induced endothelium injury is the major physiological consequence of PTE. And it is reasonal to use PTE-induced endothelium injury to stratify disease severity. According to the massive morphologic and histologic findings, rabbit models could be applied to closely mimic the human PE. Genomewide gene expression profiling has not been attempted in PTE. In this study, we determined the accuracy of rabbit autologous thrombus PTE model for human PTE disease, then we applied gene expression array to identify gene expression changes in pulmonary arteries under PTE to identify potential molecular biomarkers and signaling pathways for PTE. We detected 1343 genes were upregulated and 923 genes were downregulated in PTE rabbits. The expression of several genes (IL-8, TNF-α, and CXCL5) with functional importance were further confirmed in transcript and protein levels. The most significantly differentially regulated genes were related to inflammation, immune disease, pulmonary disease, and cardiovascular diseases. Totally 87 genes were up-regulated in the inflammatory genes. We conclude that gene expression profiling in rabbit PTE model could extend the understanding of PTE pathogenesis at the molecular level. Our study provides the fundamental framework for future clinical research on human PTE, including identification of potential biomarkers for prognosis or therapeutic targets for PTE.

  4. Rabbit Model of Human Gliomas: Implications for Intra-Arterial Drug Delivery

    Science.gov (United States)

    Qin, Huamin; Janowski, Miroslaw; Pearl, Monica S.; Malysz-Cymborska, Izabela; Li, Shen; Eberhart, Charles G.

    2017-01-01

    The prognosis for malignant brain tumors remains poor despite a combination of surgery, radiotherapy, and chemotherapy. This is partly due to the blood-brain barrier, a major obstacle that prevents therapeutic agents from effectively reaching the tumor. We have recently developed a method for precise and predictable opening of the blood-brain barrier via the intra-arterial administration of mannitol, a hyperosmolar agent, in a rabbit model, whose vascular anatomy facilitates the use of standard interventional neuroradiology techniques and devices. To date, however, no protocols are available that enable human glioma modeling in rabbits. In this article, we report on the xenotransplantation of a human glioblastoma (GBM-1) in adult New Zealand rabbits. We induced multi-drug immunosuppression (Mycophenolate Mofetil, Dexamethasone, Tacrolimus) and stereotactically implanted GBM-1 tumor cells into rabbit brains. The rabbits were followed for 42 days, monitored by MRI and body weight measurements, and underwent postmortem histopathological analysis. On MRI, brain tumors were identified on T2-weighted scans. On histopathology, tumors were detected with hematoxylin/eosin and their human origin was confirmed with immunohistochemistry against human-specific antigens. Our method for human glioma modeling in rabbits provides the foundation to test novel treatment strategies, including intra-arterial therapeutic agent delivery. PMID:28103265

  5. A deterministic partial differential equation model for dose calculation in electron radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Duclous, R; Dubroca, B [CELIA and IMB Laboratories, Bordeaux University, 33405 Talence (France); Frank, M, E-mail: duclous@celia.u-bordeaux1.f, E-mail: dubroca@celia.u-bordeaux1.f, E-mail: frank@mathcces.rwth-aachen.d [Department of Mathematics and Center for Computational Engineering Science, RWTH Aachen University, Schinkelstr. 2, 52062 Aachen (Germany)

    2010-07-07

    High-energy ionizing radiation is a prominent modality for the treatment of many cancers. The approaches to electron dose calculation can be categorized into semi-empirical models (e.g. Fermi-Eyges, convolution-superposition) and probabilistic methods (e.g. Monte Carlo). A third approach to dose calculation has only recently attracted attention in the medical physics community. This approach is based on the deterministic kinetic equations of radiative transfer. We derive a macroscopic partial differential equation model for electron transport in tissue. This model involves an angular closure in the phase space. It is exact for the free streaming and the isotropic regime. We solve it numerically by a newly developed HLLC scheme based on Berthon et al (2007 J. Sci. Comput. 31 347-89) that exactly preserves the key properties of the analytical solution on the discrete level. We discuss several test cases taken from the medical physics literature. A test case with an academic Henyey-Greenstein scattering kernel is considered. We compare our model to a benchmark discrete ordinate solution. A simplified model of electron interactions with tissue is employed to compute the dose of an electron beam in a water phantom, and a case of irradiation of the vertebral column. Here our model is compared to the PENELOPE Monte Carlo code. In the academic example, the fluences computed with the new model and a benchmark result differ by less than 1%. The depths at half maximum differ by less than 0.6%. In the two comparisons with Monte Carlo, our model gives qualitatively reasonable dose distributions. Due to the crude interaction model, these so far do not have the accuracy needed in clinical practice. However, the new model has a computational cost that is less than one-tenth of the cost of a Monte Carlo simulation. In addition, simulations can be set up in a similar way as a Monte Carlo simulation. If more detailed effects such as coupled electron-photon transport, bremsstrahlung

  6. A deterministic partial differential equation model for dose calculation in electron radiotherapy

    Science.gov (United States)

    Duclous, R.; Dubroca, B.; Frank, M.

    2010-07-01

    High-energy ionizing radiation is a prominent modality for the treatment of many cancers. The approaches to electron dose calculation can be categorized into semi-empirical models (e.g. Fermi-Eyges, convolution-superposition) and probabilistic methods (e.g. Monte Carlo). A third approach to dose calculation has only recently attracted attention in the medical physics community. This approach is based on the deterministic kinetic equations of radiative transfer. We derive a macroscopic partial differential equation model for electron transport in tissue. This model involves an angular closure in the phase space. It is exact for the free streaming and the isotropic regime. We solve it numerically by a newly developed HLLC scheme based on Berthon et al (2007 J. Sci. Comput. 31 347-89) that exactly preserves the key properties of the analytical solution on the discrete level. We discuss several test cases taken from the medical physics literature. A test case with an academic Henyey-Greenstein scattering kernel is considered. We compare our model to a benchmark discrete ordinate solution. A simplified model of electron interactions with tissue is employed to compute the dose of an electron beam in a water phantom, and a case of irradiation of the vertebral column. Here our model is compared to the PENELOPE Monte Carlo code. In the academic example, the fluences computed with the new model and a benchmark result differ by less than 1%. The depths at half maximum differ by less than 0.6%. In the two comparisons with Monte Carlo, our model gives qualitatively reasonable dose distributions. Due to the crude interaction model, these so far do not have the accuracy needed in clinical practice. However, the new model has a computational cost that is less than one-tenth of the cost of a Monte Carlo simulation. In addition, simulations can be set up in a similar way as a Monte Carlo simulation. If more detailed effects such as coupled electron-photon transport, bremsstrahlung

  7. Propagation of Partially Coherent Twisted Anisotropic Gaussian-Schell Model Beams in the Spatial-Frequency Domain

    Institute of Scientific and Technical Information of China (English)

    蔡阳健; 林强

    2002-01-01

    The generalized Collins formula for partially coherent beams through axially non-symmetrical optical systems in the spatial-frequency domain is derived by means of the tensor method. Based on this formula, the tensor ABCD law in the spatial-frequency domain for partially coherent twisted anisotropic Gaussian-Schell model (GSM) beams is derived, which governs the transformation of the twisted anisotropic GSM beams in the spatialfrequency domain. An example of an application is provided.

  8. Development of a computer-generated model for the coronary arterial tree based on multislice CT and morphometric data

    Science.gov (United States)

    Fung, George S. K.; Segars, W. Paul; Taguchi, Katsuyuki; Fishman, Elliot K.; Tsui, Benjamin M. W.

    2006-03-01

    A detailed four-dimensional model of the coronary artery tree has great potential in a wide variety of applications especially in biomedical imaging. We developed a computer generated three-dimensional model for the coronary arterial tree based on two datasets: (1) gated multi-slice computed tomography (MSCT) angiographic data obtained from a normal human subject and (2) statistical morphometric data obtained from porcine hearts. The main coronary arteries and heart structures were segmented from the MSCT data to define the initial segments of the vasculature and geometrical details of the boundaries. An iterative rule-based computer generation algorithm was then developed to extend the coronary artery tree beyond the initial segmented branches. The algorithm was governed by the following factors: (1) the statistical morphometric measurements of the connectivities, lengths, and diameters of the arterial segments, (2) repelling forces from other segments and boundaries, and (3) optimality principles to minimize the drag force at each bifurcation in the generated tree. Using this algorithm, the segmented coronary artery tree from the MSCT data was optimally extended to create a 3D computational model of the largest six orders of the coronary arterial tree. The new method for generating the 3D model is effective in imposing the constraints of anatomical and physiological characteristics of coronary vasculature. When combined with the 4D NCAT phantom, a computer model for the human anatomy and cardiac and respiratory motions, the new model will provide a unique tool to study cardiovascular characteristics and diseases through direct and medical imaging simulation studies.

  9. Comparison of models for predicting outcomes in patients with coronary artery disease focusing on microsimulation

    Directory of Open Access Journals (Sweden)

    Masoud Amiri

    2012-01-01

    Full Text Available Background: Physicians have difficulty to subjectively estimate the cardiovascular risk of their patients. Using an estimate of global cardiovascular risk could be more relevant to guide decisions than using binary representation (presence or absence of risk factors data. The main aim of the paper is to compare different models of predicting the progress of a coronary artery diseases (CAD to help the decision making of physician. Methods: There are different standard models for predicting risk factors such as models based on logistic regression model, Cox regression model, dynamic logistic regression model, and simulation models such as Markov model and microsimulation model. Each model has its own application which can or cannot use by physicians to make a decision on treatment of each patient. Results: There are five main common models for predicting of outcomes, including models based on logistic regression model (for short-term outcomes, Cox regression model (for intermediate-term outcomes, dynamic logistic regression model, and simulation models such as Markov and microsimulation models (for long-term outcomes. The advantages and disadvantages of these models have been discussed and summarized. Conclusion: Given the complex medical decisions that physicians face in everyday practice, the multiple interrelated factors that play a role in choosing the optimal treatment, and the continuously accumulating new evidence on determinants of outcome and treatment options for CAD, physicians may potentially benefit from a clinical decision support system that accounts for all these considerations. The microsimulation model could provide cardiologists, researchers, and medical students a user-friendly software, which can be used as an intelligent interventional simulator.

  10. On the necessity of modelling fluid-structure interaction for stented coronary arteries.

    Science.gov (United States)

    Chiastra, Claudio; Migliavacca, Francesco; Martínez, Miguel Ángel; Malvè, Mauro

    2014-06-01

    Although stenting is the most commonly performed procedure for the treatment of coronary atherosclerotic lesions, in-stent restenosis (ISR) remains one of the most serious clinical complications. An important stimulus to ISR is the altered hemodynamics with abnormal shear stresses on endothelial cells generated by the stent presence. Computational fluid dynamics is a valid tool for studying the local hemodynamics of stented vessels, allowing the calculation of the wall shear stress (WSS), which is otherwise not directly possible to be measured in vivo. However, in these numerical simulations the arterial wall and the stent are considered rigid and fixed, an assumption that may influence the WSS and flow patterns. Therefore, the aim of this work is to perform fluid-structure interaction (FSI) analyses of a stented coronary artery in order to understand the effects of the wall compliance on the hemodynamic quantities. Two different materials are considered for the stent: cobalt-chromium (CoCr) and poly-l-lactide (PLLA). The results of the FSI and the corresponding rigid-wall models are compared, focusing in particular on the analysis of the WSS distribution. Results showed similar trends in terms of instantaneous and time-averaged WSS between compliant and rigid-wall cases. In particular, the difference of percentage area exposed to TAWSS lower than 0.4Pa between the CoCr FSI and the rigid-wall cases was about 1.5% while between the PLLA cases 1.0%. The results indicate that, for idealized models of a stented coronary artery, the rigid-wall assumption for fluid dynamic simulations appears adequate when the aim of the study is the analysis of near-wall quantities like WSS.

  11. Lab-on-a-brane: A novel physiologically relevant planar arterial model to study transendothelial transport

    Science.gov (United States)

    Budhwani, Karim Ismail

    The tremendous quality of life impact notwithstanding, cardiovascular diseases and Cancer add up to over US$ 700bn each year in financial costs alone. Aging and population growth are expected to further expand the problem space while drug research and development remain expensive. However, preclinical costs can be substantially mitigated by substituting animal models with in vitro devices that accurately model human cardiovascular transport. Here we present a novel physiologically relevant lab-on-a-brane that simulates in vivo pressure, flow, strain, and shear waveforms associated with normal and pathological conditions in large and small blood vessels for studying molecular transport across the endothelial monolayer. The device builds upon previously demonstrated integrated microfluidic loop design by: (a) introducing nanoscale pores in the substrate membrane to enable transmembrane molecular transport, (b) transforming the substrate membrane into a nanofibrous matrix for 3D smooth muscle cell (SMC) tissue culture, (c) integrating electrospinning fabrication methods, (d) engineering an invertible sandwich cell culture device architecture, and (e) devising a healthy co-culture mechanism for human arterial endothelial cell (HAEC) monolayer and multiple layers of human smooth muscle cells (HSMC) to accurately mimic arterial anatomy. Structural and mechanical characterization was conducted using confocal microscopy, SEM, stress/strain analysis, and infrared spectroscopy. Transport was characterized using FITC-Dextran hydraulic permeability protocol. Structure and transport characterization successfully demonstrate device viability as a physiologically relevant arterial mimic for testing transendothelial transport. Thus, our lab-on-a-brane provides a highly effective and efficient, yet considerably inexpensive, physiologically relevant alternative for pharmacokinetic evaluation; possibly reducing animals used in pre-clinical testing, clinical trials cost from false

  12. The component slope linear model for calculating intensive partial molar properties /application to waste glasses and aluminate solutions

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, Jacob G. [Washington River Protection Solutions, LLC, Richland, WA (United States)

    2013-01-11

    Partial molar properties are the changes occurring when the fraction of one component is varied while the fractions of all other component mole fractions change proportionally. They have many practical and theoretical applications in chemical thermodynamics. Partial molar properties of chemical mixtures are difficult to measure because the component mole fractions must sum to one, so a change in fraction of one component must be offset with a change in one or more other components. Given that more than one component fraction is changing at a time, it is difficult to assign a change in measured response to a change in a single component. In this study, the Component Slope Linear Model (CSLM), a model previously published in the statistics literature, is shown to have coefficients that correspond to the intensive partial molar properties. If a measured property is plotted against the mole fraction of a component while keeping the proportions of all other components constant, the slope at any given point on a graph of this curve is the partial molar property for that constituent. Actually plotting this graph has been used to determine partial molar properties for many years. The CSLM directly includes this slope in a model that predicts properties as a function of the component mole fractions. This model is demonstrated by applying it to the constant pressure heat capacity data from the NaOH-NaAl(OH){sub 4}-H{sub 2}O system, a system that simplifies Hanford nuclear waste. The partial molar properties of H{sub 2}O, NaOH, and NaAl(OH){sub 4} are determined. The equivalence of the CSLM and the graphical method is verified by comparing results determined by the two methods. The CSLM model has been previously used to predict the liquidus temperature of spinel crystals precipitated from Hanford waste glass. Those model coefficients are re-interpreted here as the partial molar spinel liquidus temperature of the glass components.

  13. The Component Slope Linear Model for Calculating Intensive Partial Molar Properties: Application to Waste Glasses and Aluminate Solutions - 13099

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, Jacob G. [Washington River Protection Solutions, LLC, P.O. Box 850, Richland, WA 99352 (United States)

    2013-07-01

    Partial molar properties are the changes occurring when the fraction of one component is varied while the fractions of all other component mole fractions change proportionally. They have many practical and theoretical applications in chemical thermodynamics. Partial molar properties of chemical mixtures are difficult to measure because the component mole fractions must sum to one, so a change in fraction of one component must be offset with a change in one or more other components. Given that more than one component fraction is changing at a time, it is difficult to assign a change in measured response to a change in a single component. In this study, the Component Slope Linear Model (CSLM), a model previously published in the statistics literature, is shown to have coefficients that correspond to the intensive partial molar properties. If a measured property is plotted against the mole fraction of a component while keeping the proportions of all other components constant, the slope at any given point on a graph of this curve is the partial molar property for that constituent. Actually plotting this graph has been used to determine partial molar properties for many years. The CSLM directly includes this slope in a model that predicts properties as a function of the component mole fractions. This model is demonstrated by applying it to the constant pressure heat capacity data from the NaOHNaAl(OH){sub 4}-H{sub 2}O system, a system that simplifies Hanford nuclear waste. The partial molar properties of H{sub 2}O, NaOH, and NaAl(OH){sub 4} are determined. The equivalence of the CSLM and the graphical method is verified by comparing results determined by the two methods. The CSLM model has been previously used to predict the liquidus temperature of spinel crystals precipitated from Hanford waste glass. Those model coefficients are re-interpreted here as the partial molar spinel liquidus temperature of the glass components. (authors)

  14. Large-scale neural model validation of partial correlation analysis for effective connectivity investigation in functional MRI.

    Science.gov (United States)

    Marrelec, G; Kim, J; Doyon, J; Horwitz, B

    2009-03-01

    Recent studies of functional connectivity based upon blood oxygen level dependent functional magnetic resonance imaging have shown that this technique allows one to investigate large-scale functional brain networks. In a previous study, we advocated that data-driven measures of effective connectivity should be developed to bridge the gap between functional and effective connectivity. To attain this goal, we proposed a novel approach based on the partial correlation matrix. In this study, we further validate the use of partial correlation analysis by employing a large-scale, neurobiologically realistic neural network model to generate simulated data that we analyze with both structural equation modeling (SEM) and the partial correlation approach. Unlike real experimental data, where the interregional anatomical links are not necessarily known, the links between the nodes of the network model are fully specified, and thus provide a standard against which to judge the results of SEM and partial correlation analyses. Our results show that partial correlation analysis from the data alone exhibits patterns of effective connectivity that are similar to those found using SEM, and both are in agreement with respect to the underlying neuroarchitecture. Our findings thus provide a strong validation for the partial correlation method.

  15. Modelling the mechanics of partially mineralized collagen fibrils, fibres and tissue.

    Science.gov (United States)

    Liu, Yanxin; Thomopoulos, Stavros; Chen, Changqing; Birman, Victor; Buehler, Markus J; Genin, Guy M

    2014-03-01

    Progressive stiffening of collagen tissue by bioapatite mineral is important physiologically, but the details of this stiffening are uncertain. Unresolved questions about the details of the accommodation of bioapatite within and upon collagen's hierarchical structure have posed a central hurdle, but recent microscopy data resolve several major questions. These data suggest how collagen accommodates bioapatite at the lowest relevant hierarchical level (collagen fibrils), and suggest several possibilities for the progressive accommodation of bioapatite at higher hierarchical length scales (fibres and tissue). We developed approximations for the stiffening of collagen across spatial hierarchies based upon these data, and connected models across hierarchies levels to estimate mineralization-dependent tissue-level mechanics. In the five possible sequences of mineralization studied, percolation of the bioapatite phase proved to be an important determinant of the degree of stiffening by bioapatite. The models were applied to study one important instance of partially mineralized tissue, which occurs at the attachment of tendon to bone. All sequences of mineralization considered reproduced experimental observations of a region of tissue between tendon and bone that is more compliant than either tendon or bone, but the size and nature of this region depended strongly upon the sequence of mineralization. These models and observations have implications for engineered tissue scaffolds at the attachment of tendon to bone, bone development and graded biomimetic attachment of dissimilar hierarchical materials in general.

  16. Deletion of the App-Runx1 region in mice models human partial monosomy 21

    Directory of Open Access Journals (Sweden)

    Thomas Arbogast

    2015-06-01

    Full Text Available Partial monosomy 21 (PM21 is a rare chromosomal abnormality that is characterized by the loss of a variable segment along human chromosome 21 (Hsa21. The clinical phenotypes of this loss are heterogeneous and range from mild alterations to lethal consequences, depending on the affected region of Hsa21. The most common features include intellectual disabilities, craniofacial dysmorphology, short stature, and muscular and cardiac defects. As a complement to human genetic approaches, our team has developed new monosomic mouse models that carry deletions on Hsa21 syntenic regions in order to identify the dosage-sensitive genes that are responsible for the symptoms. We focus here on the Ms5Yah mouse model, in which a 7.7-Mb region has been deleted from the App to Runx1 genes. Ms5Yah mice display high postnatal lethality, with a few surviving individuals showing growth retardation, motor coordination deficits, and spatial learning and memory impairments. Further studies confirmed a gene dosage effect in the Ms5Yah hippocampus, and pinpointed disruptions of pathways related to cell adhesion (involving App, Cntnap5b, Lgals3bp, Mag, Mcam, Npnt, Pcdhb2, Pcdhb3, Pcdhb4, Pcdhb6, Pcdhb7, Pcdhb8, Pcdhb16 and Vwf. Our PM21 mouse model is the first to display morphological abnormalities and behavioural phenotypes similar to those found in affected humans, and it therefore demonstrates the major contribution that the App-Runx1 region has in the pathophysiology of PM21.

  17. MANUFACTURING AND CONTINUOUS IMPROVEMENT AREAS USING PARTIAL LEAST SQUARE PATH MODELING WITH MULTIPLE REGRESSION COMPARISON

    Directory of Open Access Journals (Sweden)

    Carlos Monge Perry

    2014-07-01

    Full Text Available Structural equation modeling (SEM has traditionally been deployed in areas of marketing, consumer satisfaction and preferences, human behavior, and recently in strategic planning. These areas are considered their niches; however, there is a remarkable tendency in empirical research studies that indicate a more diversified use of the technique.  This paper shows the application of structural equation modeling using partial least square (PLS-SEM, in areas of manufacturing, quality, continuous improvement, operational efficiency, and environmental responsibility in Mexico’s medium and large manufacturing plants, while using a small sample (n = 40.  The results obtained from the PLS-SEM model application mentioned, are highly positive, relevant, and statistically significant. Also shown in this paper, for purposes of validity, reliability, and statistical power confirmation of PLS-SEM, is a comparative analysis against multiple regression showing very similar results to those obtained by PLS-SEM.  This fact validates the use of PLS-SEM in areas of untraditional scientific research, and suggests and invites the use of the technique in diversified fields of the scientific research

  18. Anatomy of flavour-changing Z couplings in models with partial compositeness

    CERN Document Server

    Straub, David M

    2013-01-01

    In models with partially composite quarks, the couplings of quarks to the Z boson generically receive non-universal corrections that are not only constrained by electroweak precision tests but also lead to flavour-changing neutral currents at tree level. The impact of these flavour-changing couplings on rare K and B decays is studied in two-site models for three scenarios: an anarchic strong sector with two different choices of fermion representations both leading to a custodial protection of the Z->bb coupling, and for a strong sector invariant under a U(2)^3 flavour symmetry. In the complete numerical analysis, all relevant constraints from Delta(F)=2 processes are taken into account. In all scenarios, visible effects in rare K and B decays like K->pi nu anti-nu, B(s)->mu+mu- and B->K*mu+mu- are possible that can be scrutinized experimentally in the near future. Characteristic correlations between observables allow to distinguish the different cases. To sample the large parameter space of the anarchic model...

  19. Testing Serial Correlation in Semiparametric Varying-Coefficient Partially Linear EV Models

    Institute of Scientific and Technical Information of China (English)

    Xue-mei Hu; Zhi-zhong Wang; Feng Liu

    2008-01-01

    This paper studies estimation and serial correlation test of a semiparametric varying-coefficient partially linear EV model of the form Y = Xτβ + Zτα(T) + ε,ξ = X + η with the identifying condition E[(ε,ητ)τ] = 0, Cov[(ε,ητ)τ] = σ2Iρ+1. The estimators of interested regression parameters β, and the model error variance σ2, as well as the nonparametric components α(T), are constructed. Under some regular conditions, we show that the estimators of the unknown vector β and the unknown parameter σ2 are strongly consistent and asymptotically normal and that the estimator of α(T) achieves the optimal strong convergence rate of the usual nonparametric regression. Based on these estimators and asymptotic properties, we propose the VN,p test statistic and empirical log-likelihood ratio statistic for testing serial correlation in the model. The proposed statistics are shown to have asymptotic normal or chi-square distributions under the null hypothesis of no serial correlation. Some simulation studies are conducted to illustrate the finite sample performance of the proposed tests.

  20. Partially Automated Method for Localizing Standardized Acupuncture Points on the Heads of Digital Human Models

    Directory of Open Access Journals (Sweden)

    Jungdae Kim

    2015-01-01

    Full Text Available Having modernized imaging tools for precise positioning of acupuncture points over the human body where the traditional therapeutic method is applied is essential. For that reason, we suggest a more systematic positioning method that uses X-ray computer tomographic images to precisely position acupoints. Digital Korean human data were obtained to construct three-dimensional head-skin and skull surface models of six individuals. Depending on the method used to pinpoint the positions of the acupoints, every acupoint was classified into one of three types: anatomical points, proportional points, and morphological points. A computational algorithm and procedure were developed for partial automation of the positioning. The anatomical points were selected by using the structural characteristics of the skin surface and skull. The proportional points were calculated from the positions of the anatomical points. The morphological points were also calculated by using some control points related to the connections between the source and the target models. All the acupoints on the heads of the six individual were displayed on three-dimensional computer graphical image models. This method may be helpful for developing more accurate experimental designs and for providing more quantitative volumetric methods for performing analyses in acupuncture-related research.

  1. On the modelling and partial-load control of variable-speed wind turbines

    Energy Technology Data Exchange (ETDEWEB)

    Novak, P. [Chalmers Univ. of Technology, Goeteborg (Sweden). School of Electrical and Computer Engineering

    1995-12-31

    The focus of this thesis is on modelling and variable-speed control of wind turbines. A physical model structure including the fundamental drive-train mode is derived and validated by system-identification experiments on a full-scale wind turbine. The resulting, parametrized model has been used as a basis for an evaluation of controllers for partial-load operation, validated by non-linear simulations. This evaluation, including several controller concepts, verifies that a sophisticated controller becomes necessary, when stretching the limits in power-loss minimization. This control strategy also demands the sampling frequency to be pushed to a high level. As a consequence, the angular-position measurements become time correlated and, in the limit, periodic. It is shown in the thesis how the resulting, operating-point-dependent effects on the measurement errors influence the estimation quality, using a stationary Kalman filter as an example. A gain-scheduling estimation approach is shown to improve the performance. 39 refs, 63 figs, 2 tabs

  2. Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

    KAUST Repository

    Hossain, Shaolie S.

    2011-08-20

    The majority of heart attacks occur when there is a sudden rupture of atherosclerotic plaque, exposing prothrombotic emboli to coronary blood flow, forming clots that can cause blockages of the arterial lumen. Diseased arteries can be treated with drugs delivered locally to vulnerable plaques. The objective of this work was to develop a computational tool-set to support the design and analysis of a catheter-based nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. A threedimensional mathematical model of coupled mass transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis. Simulations were run on a patient-specific multilayered coronary artery wall segment with a vulnerable plaque and the effect of artery and plaque inhomogeneity was analyzed. The method captured trends observed in local drug delivery and demonstrated potential for optimizing drug design parameters, including delivery location, nanoparticle surface properties, and drug release rate. © Springer-Verlag 2011.

  3. Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

    Science.gov (United States)

    Hossain, Shaolie S.; Hossainy, Syed F. A.; Bazilevs, Yuri; Calo, Victor M.; Hughes, Thomas J. R.

    2012-02-01

    The majority of heart attacks occur when there is a sudden rupture of atherosclerotic plaque, exposing prothrombotic emboli to coronary blood flow, forming clots that can cause blockages of the arterial lumen. Diseased arteries can be treated with drugs delivered locally to vulnerable plaques. The objective of this work was to develop a computational tool-set to support the design and analysis of a catheter-based nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. A three-dimensional mathematical model of coupled mass transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis. Simulations were run on a patient-specific multilayered coronary artery wall segment with a vulnerable plaque and the effect of artery and plaque inhomogeneity was analyzed. The method captured trends observed in local drug delivery and demonstrated potential for optimizing drug design parameters, including delivery location, nanoparticle surface properties, and drug release rate.

  4. Hemodynamic analysis in an idealized artery tree: differences in wall shear stress between Newtonian and non-Newtonian blood models.

    Science.gov (United States)

    Weddell, Jared C; Kwack, JaeHyuk; Imoukhuede, P I; Masud, Arif

    2015-01-01

    Development of many conditions and disorders, such as atherosclerosis and stroke, are dependent upon hemodynamic forces. To accurately predict and prevent these conditions and disorders hemodynamic forces must be properly mapped. Here we compare a shear-rate dependent fluid (SDF) constitutive model, based on the works by Yasuda et al in 1981, against a Newtonian model of blood. We verify our stabilized finite element numerical method with the benchmark lid-driven cavity flow problem. Numerical simulations show that the Newtonian model gives similar velocity profiles in the 2-dimensional cavity given different height and width dimensions, given the same Reynolds number. Conversely, the SDF model gave dissimilar velocity profiles, differing from the Newtonian velocity profiles by up to 25% in velocity magnitudes. This difference can affect estimation in platelet distribution within blood vessels or magnetic nanoparticle delivery. Wall shear stress (WSS) is an important quantity involved in vascular remodeling through integrin and adhesion molecule mechanotransduction. The SDF model gave a 7.3-fold greater WSS than the Newtonian model at the top of the 3-dimensional cavity. The SDF model gave a 37.7-fold greater WSS than the Newtonian model at artery walls located immediately after bifurcations in the idealized femoral artery tree. The pressure drop across arteries reveals arterial sections highly resistive to flow which correlates with stenosis formation. Numerical simulations give the pressure drop across the idealized femoral artery tree with the SDF model which is approximately 2.3-fold higher than with the Newtonian model. In atherosclerotic lesion models, the SDF model gives over 1 Pa higher WSS than the Newtonian model, a difference correlated with over twice as many adherent monocytes to endothelial cells from the Newtonian model compared to the SDF model.

  5. Hemodynamic analysis in an idealized artery tree: differences in wall shear stress between Newtonian and non-Newtonian blood models.

    Directory of Open Access Journals (Sweden)

    Jared C Weddell

    Full Text Available Development of many conditions and disorders, such as atherosclerosis and stroke, are dependent upon hemodynamic forces. To accurately predict and prevent these conditions and disorders hemodynamic forces must be properly mapped. Here we compare a shear-rate dependent fluid (SDF constitutive model, based on the works by Yasuda et al in 1981, against a Newtonian model of blood. We verify our stabilized finite element numerical method with the benchmark lid-driven cavity flow problem. Numerical simulations show that the Newtonian model gives similar velocity profiles in the 2-dimensional cavity given different height and width dimensions, given the same Reynolds number. Conversely, the SDF model gave dissimilar velocity profiles, differing from the Newtonian velocity profiles by up to 25% in velocity magnitudes. This difference can affect estimation in platelet distribution within blood vessels or magnetic nanoparticle delivery. Wall shear stress (WSS is an important quantity involved in vascular remodeling through integrin and adhesion molecule mechanotransduction. The SDF model gave a 7.3-fold greater WSS than the Newtonian model at the top of the 3-dimensional cavity. The SDF model gave a 37.7-fold greater WSS than the Newtonian model at artery walls located immediately after bifurcations in the idealized femoral artery tree. The pressure drop across arteries reveals arterial sections highly resistive to flow which correlates with stenosis formation. Numerical simulations give the pressure drop across the idealized femoral artery tree with the SDF model which is approximately 2.3-fold higher than with the Newtonian model. In atherosclerotic lesion models, the SDF model gives over 1 Pa higher WSS than the Newtonian model, a difference correlated with over twice as many adherent monocytes to endothelial cells from the Newtonian model compared to the SDF model.

  6. Granulocyte colony-stimulating factor ameliorates coronary artery elastin breakdown in a mouse model of Kawasaki disease

    Institute of Scientific and Technical Information of China (English)

    Liu Junfeng; Chen Zhi; Du Zhongdong; Lu Dunxiang

    2014-01-01

    Background Coronary artery damage from Kawasaki disease (KD) is closely linked to the dysfunction of the endothelial progenitor cells (EPCs).The aim of the present study was to evaluate the modulatory effect of granulocyte colony stimulating factor (G-CSF) on EPCs and elastin breakdown of coronary arteries in a KD mouse model.Methods A Lactobacillus casei cell wall extract (LCWE)-induced KD model was established in C57BL/6 mice that were subsequently administrated with recombinant human G-CSF (rhG-CSF).Nω-nitro-L-arginine methyl ester (L-NAME) was administrated for the negative intervention.Evaluations included coronary artery lesions,EPC number and functions,and the plasma concentration of nitric oxide (NO).Results Elastin breakdown was found in the coronary arteries of model mice 56 days after injection of LCWE.The number of circulating EPCs,plasma concentration of NO,and functions of bone marrow EPCs,including proliferation,adhesion,and migration abilities,were all lower in the KD model group compared with those in the control group.After administration of rhG-CSF,the number of circulating EPCs and plasma concentration of NO were increased significantly compared with those in the KD model group.There were also increases in the functional indexes of EPCs.Furthermore,rhG-CSF administration improved the elastin breakdown effectively.However,these protective effects of rhG-CSF on coronary arteries were attenuated by L-NAME.Conclusion The present study indicated that the administration of G-CSF prevents elastin breakdown of the coronary arteries by enhancing the number and functions of EPCs via the NO system,and then accelerates the repair of coronary artery lesions in the KD.

  7. Murine partial-body radiation exposure model for biodosimetry studies - Preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Blakely, William F., E-mail: blakely@afrri.usuhs.mil [Uniformed Services University, Armed Forces Radiobiology Research Institute, Scientific Research Department, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603 (United States); Sandgren, David J., E-mail: Sandgren@afrri.usuhs.mil [Uniformed Services University, Armed Forces Radiobiology Research Institute, Scientific Research Department, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603 (United States); Nagy, Vitaly, E-mail: nagy@afrri.usuhs.mil [Uniformed Services University, Armed Forces Radiobiology Research Institute, Scientific Research Department, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603 (United States); Kim, Sung-Yop, E-mail: kimy@afrri.usuhs.mil [Uniformed Services University, Armed Forces Radiobiology Research Institute, Scientific Research Department, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603 (United States); Ossetrova, Natalia I., E-mail: ossetrova@afrri.usuhs.mil [Uniformed Services University, Armed Forces Radiobiology Research Institute, Scientific Research Department, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603 (United States)

    2011-09-15

    The objective of the present study was to establish a murine partial-body radiation exposure model for studies supporting the identification and validation of novel biological dosimetry diagnostic assays. A lead shielding - Plexiglas irradiation apparatus with cutouts to permit irradiation of single-mouse-holder constrained CD2F1 male mice to total-body (3/3), mid- and lower-body (2/3), mid-body only (1/3), and 100% lead shielding sham-treated (0 Gy) controls (0/3) with a 250-kVp X-ray source (dose: 6 Gy, dose rate: 0.50 Gy min{sup -1}) was used. Doses and dose uniformity were measured using alanine - electron paramagnetic resonance (EPR) and ionization chambers. Dosimetry mapping results showed {approx}2 and {approx}12% non-uniformity in the radiation fields for the two smaller (1/3, 2/3) and one larger (3/3) fields, respectively. Hematology results showed no marked differences in neutrophil and platelet counts 1 and 2 days (d) after irradiation. The lymphocyte counts, as expected, demonstrate a progressive decline below baseline levels 1 and 2 d after irradiation with increasing fraction of the body exposed, while the neutrophil to lymphocyte ratios show the inverse effect, with a progressive increase with the fraction of body exposed. The bone marrow biomarker, Flt3 ligand, demonstrated a progressive increase in values with increasing fraction of the body exposed; the 2 d response was enhanced compared to 1 d. The radioresponse 1 d after irradiation for the acute phase reactant protein biomarker, serum amyloid A (SAA) that is synthesized by the liver, was significantly influenced depending on whether the mouse head was in the radiation field. Use of multiple biomarkers based on hematology and proteomic targets provide an enhancement in early-phase partial-body radiation exposure assessment.

  8. Modelling mercury accumulation in minerogenic peat combining FTIR-ATR spectroscopy and partial least squares (PLS)

    Science.gov (United States)

    Pérez-Rodríguez, Marta; Horák-Terra, Ingrid; Rodríguez-Lado, Luis; Martínez Cortizas, Antonio

    2016-11-01

    Despite its potential, infrared spectroscopy combined with multivariate statistics has been seldom used to model peat properties with environmental value, such us the concentration of potentially toxic metals. In this research, we applied attenuated total reflectance (ATR) Fourier-Transform Infrared (FTIR) spectroscopy to evaluate the ability of the technique to predict mercury concentrations in late-Pleistocene/Holocene peat from a minerogenic peatland from Minas Gerais (Brazil). Mercury concentrations were analysed using a Milestone DMA-80 analyzer and attenuated total reflectance FTIR-ATR was performed using a Gladi-ATR (Pike Technologies) in the mid IR spectrum (4000-400 cm- 1). Concentrations were modelled using principal components (PCR) and partial least squares regression (PLS). The performance of the models varied between moderate and very good (R2 0.67-0.90), with low RMSD values (0.35-1.06). A PLS model based on three latent vectors (LV1 to LV3) provided the best (R2 0.90, RMSD 0.35) results. LV1 reflected total organic matter content versus mineral matter (mainly quartz from local fluxes), LV2 was related to dust deposition from regional sources, and LV3 reflected peat organic matter decomposition. Compared to a previous investigation based on geochemical data, the spectroscopy-based PLS model performed better, but it has to be complemented with additional data (as δ13 C ratios) to reliably reproduce the changes of the factors controlling mercury accumulation over time. This, time- and cost-effective, methodology may help to develop multi-core approaches to study the within and between mire (of a similar type and area) variability in mercury accumulation, and probably also other peat properties.

  9. Extracerebral Tissue Damage in the Intraluminal Filament Mouse Model of Middle Cerebral Artery Occlusion

    Science.gov (United States)

    Vaas, Markus; Ni, Ruiqing; Rudin, Markus; Kipar, Anja; Klohs, Jan

    2017-01-01

    Middle cerebral artery occlusion is the most common model of focal cerebral ischemia in the mouse. In the surgical procedure, the external carotid artery (ECA) is ligated; however, its effect on the tissue supplied by the vessel has not been described so far. C57BL/6 mice underwent 1 h of transient MCAO (tMCAO) or sham surgery. Multi-spectral optoacoustic tomography was employed at 30 min after surgery to assess oxygenation in the temporal muscles. Microstructural changes were assessed with magnetic resonance imaging and histological examination at 24 h and 48 h after surgery. Ligation of the ECA resulted in decreased oxygenation of the left temporal muscle in most sham-operated and tMCAO animals. Susceptible mice of both groups exhibited increased T2 relaxation times in the affected muscle with histological evidence of myofibre degeneration, interstitial edema, and neutrophil influx. Ligatures had induced an extensive neutrophil-dominated inflammatory response. ECA ligation leads to distinct hypoxic degenerative changes in the tissue of the ECA territory and to ligature-induced inflammatory processes. An impact on outcome needs to be considered in this stroke model. PMID:28348545

  10. An Arterial Signal Coordination Optimization Model for Trams Based on Modified AM-BAND

    Directory of Open Access Journals (Sweden)

    Yangfan Zhou

    2016-01-01

    Full Text Available Modern trams are developing fast because of their characteristics like medium capability and energy saving. Exclusive way is always set in practice to avoid interruption from general vehicles, while trams have to stop at intersections frequently due to signal rules in the road network. Therefore, signal optimization has great effects on operational efficiency of trams system. In this paper, an arterial signal coordination optimization model is proposed for trams progression based on the Asymmetrical Multi-BAND (AM-BAND method. The AM-BAND is modified from the following aspects. Firstly, BAM-BAND is developed by supplementing active bandwidth constraints to AM-BAND. Assisted by the IBM ILOG CPLEX Optimization Studio, two arterial signals plans with eight intersections are achieved from AM-BAND and BAM-BAND for comparison. Secondly, based on the modified BAM-BAND, a BAM-TRAMBAND model is presented, which incorporates three constraints regarding tram operations, including dwell time at stations, active signal priority, and minimum bandwidth value. The case study and VISSIM simulation results show that travel times of trams decrease with signal plan from BAM-TRAMBAND comparing with the original signal plan. Moreover, traffic performance indicators such as stops and delay are improved significantly.

  11. Effect of hypertension on low-density lipoprotein transport within a multi-layered arterial wall: modelling consistent with experiments

    CERN Document Server

    Jesionek, Katarzyna; Kostur, Marcin

    2016-01-01

    The influence of hypertension on low-density lipoproteins intake into the arterial wall is an important factor for understanding mechanisms of atherosclerosis. It has been experimentally observed that the increased pressure leads to the higher level of the LDL inside the wall. In this paper we attempt to construct a model of the LDL transport which reproduces quantitatively experimental outcomes. We supplement the well known four-layer arterial wall model to include two pressure induced effects: the compression of the intima tissue and the increase of the fraction of leaky junctions. We demonstrate that such model can reach the very good agreement with experimental data.

  12. Simulation of Variable Viscosity and Jeffrey Fluid Model for Blood Flow Through a Tapered Artery with a Stenosis

    Institute of Scientific and Technical Information of China (English)

    Noreen Sher Akbar; S. Nadeem

    2012-01-01

    Non-Newtonian fluid model for blood flow through a tapered artery with a stenosis and variable viscosity by modeling blood as Jeffrey fluid has been studied in this paper. The Jeffrey fluid has two parameters, the relaxation time A1 and retardation time A2. The governing equations are simplified using the case of mild stenosis. Perturbation method is used to solve the resulting equations. The effects of non-Newtonian nature of blood on velocity profile, temperature profile, wall shear stress, shearing stress at the stenotsis throat and impedance of the artery are discussed. The results for Newtonian fluid are obtained as special case from this model.

  13. A Multidimensional Partial Credit Model with Associated Item and Test Statistics: An Application to Mixed-Format Tests

    Science.gov (United States)

    Yao, Lihua; Schwarz, Richard D.

    2006-01-01

    Multidimensional item response theory (IRT) models have been proposed for better understanding the dimensional structure of data or to define diagnostic profiles of student learning. A compensatory multidimensional two-parameter partial credit model (M-2PPC) for constructed-response items is presented that is a generalization of those proposed to…

  14. Automated detection of arterial input function in DSC perfusion MRI in a stroke rat model

    Science.gov (United States)

    Yeh, M.-Y.; Lee, T.-H.; Yang, S.-T.; Kuo, H.-H.; Chyi, T.-K.; Liu, H.-L.

    2009-05-01

    Quantitative cerebral blood flow (CBF) estimation requires deconvolution of the tissue concentration time curves with an arterial input function (AIF). However, image-based determination of AIF in rodent is challenged due to limited spatial resolution. We evaluated the feasibility of quantitative analysis using automated AIF detection and compared the results with commonly applied semi-quantitative analysis. Permanent occlusion of bilateral or unilateral common carotid artery was used to induce cerebral ischemia in rats. The image using dynamic susceptibility contrast method was performed on a 3-T magnetic resonance scanner with a spin-echo echo-planar-image sequence (TR/TE = 700/80 ms, FOV = 41 mm, matrix = 64, 3 slices, SW = 2 mm), starting from 7 s prior to contrast injection (1.2 ml/kg) at four different time points. For quantitative analysis, CBF was calculated by the AIF which was obtained from 10 voxels with greatest contrast enhancement after deconvolution. For semi-quantitative analysis, relative CBF was estimated by the integral divided by the first moment of the relaxivity time curves. We observed if the AIFs obtained in the three different ROIs (whole brain, hemisphere without lesion and hemisphere with lesion) were similar, the CBF ratios (lesion/normal) between quantitative and semi-quantitative analyses might have a similar trend at different operative time points. If the AIFs were different, the CBF ratios might be different. We concluded that using local maximum one can define proper AIF without knowing the anatomical location of arteries in a stroke rat model.

  15. Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model

    Science.gov (United States)

    Salmon, Asher; Peretz, Tamar; Galun, Eithan; Axelrod, Jonathan H.; Sonnenblick, Amir

    2016-01-01

    The long-term prognosis after resection of hepatocellular carcinoma (HCC), which is one of the treatment options for early-stage HCC, remains unsatisfactory as a result of a high incidence of disease recurrence. Recent studies performed in murine models revealed a link between liver regeneration under chronic inflammation and hepatic tumorigenesis. Sorafenib is a potent drug for advanced HCC with multikinase inhibition activity. We propose that inhibition of signal transduction pathways which are activated during hepatectomy, using Sorafenib, will reduce accelerated tumorigenesis. To test this hypothesis, we studied the Mdr2-knockout (KO) mouse strain, a model of inflammation-associated cancer, which underwent partial hepatectomy (PHx) at three months of age, with or without Sorafenib. Here we show that Sorafenib treatment during PHx inhibited different signal transduction pathways at the multikinase levels, but did not result in increased morbidity or mortality. At the early stages after PHx, Sorafenib treatment had no effect on the course of proliferation, apoptosis and DNA repair in the regenerating liver, but resulted in decreased stellate cells activation and inflammatory response. Finally, we show that Sorafenib treatment during PHx at three months of age resulted in decreased fibrosis and tumor formation at 8.5 months. In conclusion our study indicates that short-term Sorafenib treatment during PHx is safe and effective in inhibiting inflammation-associated cancer, and is therefore a potential strategy for recurrence prevention in patients with early-stage HCC treated with PHx. PMID:26695439

  16. Some general remarks on hyperplasticity modelling and its extension to partially saturated soils

    Science.gov (United States)

    Lei, Xiaoqin; Wong, Henry; Fabbri, Antonin; Bui, Tuan Anh; Limam, Ali

    2016-06-01

    The essential ideas and equations of classic plasticity and hyperplasticity are successively recalled and compared, in order to highlight their differences and complementarities. The former is based on the mathematical framework proposed by Hill (The mathematical theory of plasticity. Oxford University Press, Oxford, 1950), whereas the latter is founded on the orthogonality hypothesis of Ziegler (An introduction to thermomechanics. Elsevier, North-Holland, 1983). The main drawback of classic plasticity is the possibility of violating the second principle of thermodynamics, while the relative ease to conjecture the yield function in order to approach experimental results is its main advantage. By opposition, the a priori satisfaction of thermodynamic principles constitutes the chief advantage of hyperplasticity theory. Noteworthy is also the fact that this latter approach allows a finer energy partition; in particular, the existence of frozen energy emerges as a natural consequence from its theoretical formulation. On the other hand, the relative difficulty to conjecture an efficient dissipation function to produce accurate predictions is its main drawback. The two theories are thus better viewed as two complementary approaches. Following this comparative study, a methodology to extend the hyperplasticity approach initially developed for dry or saturated materials to the case of partially saturated materials, accounting for interface energies and suction effects, is developed. A particular example based on the yield function of modified Cam-Clay model is then presented. It is shown that the approach developed leads to a model consistent with other existing works.

  17. Exploring the chemical kinetics of partially oxidized intermediates by combining experiments, theory, and kinetic modeling.

    Science.gov (United States)

    Hoyermann, Karlheinz; Mauß, Fabian; Olzmann, Matthias; Welz, Oliver; Zeuch, Thomas

    2017-07-19

    Partially oxidized intermediates play a central role in combustion and atmospheric chemistry. In this perspective, we focus on the chemical kinetics of alkoxy radicals, peroxy radicals, and Criegee intermediates, which are key species in both combustion and atmospheric environments. These reactive intermediates feature a broad spectrum of chemical diversity. Their reactivity is central to our understanding of how volatile organic compounds are degraded in the atmosphere and converted into secondary organic aerosol. Moreover, they sensitively determine ignition timing in internal combustion engines. The intention of this perspective article is to provide the reader with information about the general mechanisms of reactions initiated by addition of atomic and molecular oxygen to alkyl radicals and ozone to alkenes. We will focus on critical branching points in the subsequent reaction mechanisms and discuss them from a consistent point of view. As a first example of our integrated approach, we will show how experiment, theory, and kinetic modeling have been successfully combined in the first infrared detection of Criegee intermediates during the gas phase ozonolysis. As a second example, we will examine the ignition timing of n-heptane/air mixtures at low and intermediate temperatures. Here, we present a reduced, fuel size independent kinetic model of the complex chemistry initiated by peroxy radicals that has been successfully applied to simulate standard n-heptane combustion experiments.

  18. A partially open porous media flow with chaotic advection: towards a model of coupled fields.

    Science.gov (United States)

    Metcalfe, Guy; Lester, Daniel; Ord, Alison; Kulkarni, Pandurang; Trefry, Mike; Hobbs, Bruce E; Regenaur-Lieb, Klaus; Morris, Jeffery

    2010-01-13

    In nature, dissipative fluxes of fluid, heat and/or reacting species couple to each other and may also couple to deformation of a surrounding porous matrix. We use the well-known analogy of Hele-Shaw flow to Darcy flow to make a model porous medium with porosity proportional to local cell height. Time- and space-varying fluid injection from multiple source/sink wells lets us create many different kinds of chaotic flows and chemical concentration patterns. Results of an initial time-dependent potential flow model illustrate that this is a partially open flow, in which parts of the material transported by the flow remain in the cell forever and parts pass through with residence time and exit time distributions that have self-similar features in the control parameter space of the stirring. We derive analytically the existence boundary in stirring control parameter space between where isolated fluid regions can and cannot remain forever in the open flow. Experiments confirm the predictions.

  19. Modeling and optimization of catalytic partial oxidation methane reforming for fuel cells

    Science.gov (United States)

    Chaniotis, A. K.; Poulikakos, D.

    The objective of this paper is the investigation and optimization of a micro-reformer for a fuel cell unit based on catalytic partial oxidation using a systematic numerical study of chemical composition and inflow conditions. The optimization targets hydrogen production from methane. Additionally, the operating temperature, the amount of carbon formation and the methane conversion efficiency are taking into account. The fundamental investigation is first based on simplified reactor models (surface perfectly stirred reactor (SPRS)). A detailed surface chemistry mechanism is adopted in order to capture all the important features of the reforming process. As a consequence, the residence time of the process is taken into account, which means that the products are not necessary in equilibrium. Subsequently, in order to test the validity of the findings from the simplified reactor model, more detailed simulations (involving the Navier-Stokes equations) were performed for the regions of interest. A region where all the targeted operating conditions are satisfied and the yield of hydrogen is around 80% is identified.

  20. Corticomuscular Activity Modeling by Combining Partial Least Squares and Canonical Correlation Analysis

    Directory of Open Access Journals (Sweden)

    Xun Chen

    2013-01-01

    Full Text Available Corticomuscular activity modeling based on multiple data sets such as electroencephalography (EEG and electromyography (EMG signals provides a useful tool for understanding human motor control systems. In this paper, we propose modeling corticomuscular activity by combining partial least squares (PLS and canonical correlation analysis (CCA. The proposed method takes advantage of both PLS and CCA to ensure that the extracted components are maximally correlated across two data sets and meanwhile can well explain the information within each data set. This complementary combination generalizes the statistical assumptions beyond both PLS and CCA methods. Simulations were performed to illustrate the performance of the proposed method. We also applied the proposed method to concurrent EEG and EMG data collected in a Parkinson’s disease (PD study. The results reveal several highly correlated temporal patterns between EEG and EMG signals and indicate meaningful corresponding spatial activation patterns. In PD subjects, enhanced connections between occipital region and other regions are noted, which is consistent with previous medical knowledge. The proposed framework is a promising technique for performing multisubject and bimodal data analysis.

  1. Liver cancer arterial perfusion modelling and CFD boundary conditions methodology: a case study of the haemodynamics of a patient-specific hepatic artery in literature-based healthy and tumour-bearing liver scenarios.

    Science.gov (United States)

    Aramburu, Jorge; Antón, Raúl; Rivas, Alejandro; Ramos, Juan Carlos; Sangro, Bruno; Bilbao, José Ignacio

    2016-11-01

    Some of the latest treatments for unresectable liver malignancies (primary or metastatic tumours), which include bland embolisation, chemoembolisation, and radioembolisation, among others, take advantage of the increased arterial blood supply to the tumours to locally attack them. A better understanding of the factors that influence this transport may help improve the therapeutic procedures by taking advantage of flow patterns or by designing catheters and infusion systems that result in the injected beads having increased access to the tumour vasculature. Computational analyses may help understand the haemodynamic patterns and embolic-microsphere transport through the hepatic arteries. In addition, physiological inflow and outflow boundary conditions are essential in order to reliably represent the blood flow through arteries. This study presents a liver cancer arterial perfusion model based on a literature review and derives boundary conditions for tumour-bearing liver-feeding hepatic arteries based on the arterial perfusion characteristics of normal and tumorous liver segment tissue masses and the hepatic artery branching configuration. Literature-based healthy and tumour-bearing realistic scenarios are created and haemodynamically analysed for the same patient-specific hepatic artery. As a result, this study provides boundary conditions for computational fluid dynamics simulations that will allow researchers to numerically study, for example, various intravascular devices used for liver disease intra-arterial treatments with different cancer scenarios. Copyright © 2016 John Wiley & Sons, Ltd.

  2. Modeling the transport of drugs eluted from stents: physical phenomena driving drug distribution in the arterial wall.

    Science.gov (United States)

    Bozsak, Franz; Chomaz, Jean-Marc; Barakat, Abdul I

    2014-04-01

    Despite recent data that suggest that the overall performance of drug-eluting stents (DES) is superior to that of bare-metal stents, the long-term safety and efficacy of DES remain controversial. The risk of late stent thrombosis associated with the use of DES has also motivated the development of a new and promising treatment option in recent years, namely drug-coated balloons (DCB). Contrary to DES where the drug of choice is typically sirolimus and its derivatives, DCB use paclitaxel since the use of sirolimus does not appear to lead to satisfactory results. Since both sirolimus and paclitaxel are highly lipophilic drugs with similar transport properties, the reason for the success of paclitaxel but not sirolimus in DCB remains unclear. Computational models of the transport of drugs eluted from DES or DCB within the arterial wall promise to enhance our understanding of the performance of these devices. The present study develops a computational model of the transport of the two drugs paclitaxel and sirolimus eluted from DES in the arterial wall. The model takes into account the multilayered structure of the arterial wall and incorporates a reversible binding model to describe drug interactions with the constituents of the arterial wall. The present results demonstrate that the transport of paclitaxel in the arterial wall is dominated by convection while the transport of sirolimus is dominated by the binding process. These marked differences suggest that drug release kinetics of DES should be tailored to the type of drug used.

  3. Minimal moment equations for stochastic models of biochemical reaction networks with partially finite state space.

    Science.gov (United States)

    Ruess, Jakob

    2015-12-28

    Many stochastic models of biochemical reaction networks contain some chemical species for which the number of molecules that are present in the system can only be finite (for instance due to conservation laws), but also other species that can be present in arbitrarily large amounts. The prime example of such networks are models of gene expression, which typically contain a small and finite number of possible states for the promoter but an infinite number of possible states for the amount of mRNA and protein. One of the main approaches to analyze such models is through the use of equations for the time evolution of moments of the chemical species. Recently, a new approach based on conditional moments of the species with infinite state space given all the different possible states of the finite species has been proposed. It was argued that this approach allows one to capture more details about the full underlying probability distribution with a smaller number of equations. Here, I show that the result that less moments provide more information can only stem from an unnecessarily complicated description of the system in the classical formulation. The foundation of this argument will be the derivation of moment equations that describe the complete probability distribution over the finite state space but only low-order moments over the infinite state space. I will show that the number of equations that is needed is always less than what was previously claimed and always less than the number of conditional moment equations up to the same order. To support these arguments, a symbolic algorithm is provided that can be used to derive minimal systems of unconditional moment equations for models with partially finite state space.

  4. Minimal moment equations for stochastic models of biochemical reaction networks with partially finite state space

    Science.gov (United States)

    Ruess, Jakob

    2015-12-01

    Many stochastic models of biochemical reaction networks contain some chemical species for which the number of molecules that are present in the system can only be finite (for instance due to conservation laws), but also other species that can be present in arbitrarily large amounts. The prime example of such networks are models of gene expression, which typically contain a small and finite number of possible states for the promoter but an infinite number of possible states for the amount of mRNA and protein. One of the main approaches to analyze such models is through the use of equations for the time evolution of moments of the chemical species. Recently, a new approach based on conditional moments of the species with infinite state space given all the different possible states of the finite species has been proposed. It was argued that this approach allows one to capture more details about the full underlying probability distribution with a smaller number of equations. Here, I show that the result that less moments provide more information can only stem from an unnecessarily complicated description of the system in the classical formulation. The foundation of this argument will be the derivation of moment equations that describe the complete probability distribution over the finite state space but only low-order moments over the infinite state space. I will show that the number of equations that is needed is always less than what was previously claimed and always less than the number of conditional moment equations up to the same order. To support these arguments, a symbolic algorithm is provided that can be used to derive minimal systems of unconditional moment equations for models with partially finite state space.

  5. An ontology-driven, case-based clinical decision support model for removable partial denture design

    Science.gov (United States)

    Chen, Qingxiao; Wu, Ji; Li, Shusen; Lyu, Peijun; Wang, Yong; Li, Miao

    2016-06-01

    We present the initial work toward developing a clinical decision support model for specific design of removable partial dentures (RPDs) in dentistry. We developed an ontological paradigm to represent knowledge of a patient’s oral conditions and denture component parts. During the case-based reasoning process, a cosine similarity algorithm was applied to calculate similarity values between input patients and standard ontology cases. A group of designs from the most similar cases were output as the final results. To evaluate this model, the output designs of RPDs for 104 randomly selected patients were compared with those selected by professionals. An area under the curve of the receiver operating characteristic (AUC-ROC) was created by plotting true-positive rates against the false-positive rate at various threshold settings. The precision at position 5 of the retrieved cases was 0.67 and at the top of the curve it was 0.96, both of which are very high. The mean average of precision (MAP) was 0.61 and the normalized discounted cumulative gain (NDCG) was 0.74 both of which confirmed the efficient performance of our model. All the metrics demonstrated the efficiency of our model. This methodology merits further research development to match clinical applications for designing RPDs. This paper is organized as follows. After the introduction and description of the basis for the paper, the evaluation and results are presented in Section 2. Section 3 provides a discussion of the methodology and results. Section 4 describes the details of the ontology, similarity algorithm, and application.

  6. Modeling of Kidney Hemodynamics: Probability-Based Topology of an Arterial Network

    DEFF Research Database (Denmark)

    Postnov, Dmitry; Marsh, Donald; Postnov, D.E.;

    2016-01-01

    Through regulation of the extracellular fluid volume, the kidneys provide important long-term regulation of blood pressure. At the level of the individual functional unit (the nephron), pressure and flow control involves two different mechanisms that both produce oscillations. The nephrons...... are arranged in a complex branching structure that delivers blood to each nephron and, at the same time, provides a basis for an interaction between adjacent nephrons. The functional consequences of this interaction are not understood, and at present it is not possible to address this question experimentally......CT) data we develop an algorithm for generating the renal arterial network. We then introduce a mathematical model describing blood flow dynamics and nephron to nephron interaction in the network. The model includes an implementation of electrical signal propagation along a vascular wall. Simulation...

  7. Spatially explicit models for inference about density in unmarked or partially marked populations

    Science.gov (United States)

    Chandler, Richard B.; Royle, J. Andrew

    2013-01-01

    Recently developed spatial capture–recapture (SCR) models represent a major advance over traditional capture–recapture (CR) models because they yield explicit estimates of animal density instead of population size within an unknown area. Furthermore, unlike nonspatial CR methods, SCR models account for heterogeneity in capture probability arising from the juxtaposition of animal activity centers and sample locations. Although the utility of SCR methods is gaining recognition, the requirement that all individuals can be uniquely identified excludes their use in many contexts. In this paper, we develop models for situations in which individual recognition is not possible, thereby allowing SCR concepts to be applied in studies of unmarked or partially marked populations. The data required for our model are spatially referenced counts made on one or more sample occasions at a collection of closely spaced sample units such that individuals can be encountered at multiple locations. Our approach includes a spatial point process for the animal activity centers and uses the spatial correlation in counts as information about the number and location of the activity centers. Camera-traps, hair snares, track plates, sound recordings, and even point counts can yield spatially correlated count data, and thus our model is widely applicable. A simulation study demonstrated that while the posterior mean exhibits frequentist bias on the order of 5–10% in small samples, the posterior mode is an accurate point estimator as long as adequate spatial correlation is present. Marking a subset of the population substantially increases posterior precision and is recommended whenever possible. We applied our model to avian point count data collected on an unmarked population of the northern parula (Parula americana) and obtained a density estimate (posterior mode) of 0.38 (95% CI: 0.19–1.64) birds/ha. Our paper challenges sampling and analytical conventions in ecology by demonstrating

  8. Computational fluid dynamics of the right ventricular outflow tract and of the pulmonary artery: a bench model of flow dynamics.

    Science.gov (United States)

    Mosbahi, Selim; Mickaily-Huber, Elizabeth; Charbonnier, Dominique; Hullin, Roger; Burki, Marco; Ferrari, Enrico; von Segesser, Ludwig K; Berdajs, Denis A

    2014-10-01

    The reconstruction of the right ventricular outflow tract (RVOT) with valved conduits remains a challenge. The reoperation rate at 5 years can be as high as 25% and depends on age, type of conduit, conduit diameter and principal heart malformation. The aim of this study is to provide a bench model with computer fluid dynamics to analyse the haemodynamics of the RVOT, pulmonary artery, its bifurcation, and left and right pulmonary arteries that in the future may serve as a tool for analysis and prediction of outcome following RVOT reconstruction. Pressure, flow and diameter at the RVOT, pulmonary artery, bifurcation of the pulmonary artery, and left and right pulmonary arteries were measured in five normal pigs with a mean weight of 24.6 ± 0.89 kg. Data obtained were used for a 3D computer fluid-dynamics simulation of flow conditions, focusing on the pressure, flow and shear stress profile of the pulmonary trunk to the level of the left and right pulmonary arteries. Three inlet steady flow profiles were obtained at 0.2, 0.29 and 0.36 m/s that correspond to the flow rates of 1.5, 2.0 and 2.5 l/min flow at the RVOT. The flow velocity profile was constant at the RVOT down to the bifurcation and decreased at the left and right pulmonary arteries. In all three inlet velocity profiles, low sheer stress and low-velocity areas were detected along the left wall of the pulmonary artery, at the pulmonary artery bifurcation and at the ostia of both pulmonary arteries. This computed fluid real-time model provides us with a realistic picture of fluid dynamics in the pulmonary tract area. Deep shear stress areas correspond to a turbulent flow profile that is a predictive factor for the development of vessel wall arteriosclerosis. We believe that this bench model may be a useful tool for further evaluation of RVOT pathology following surgical reconstructions. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery

  9. Integrative modeling of small artery structure and function uncovers critical parameters for diameter regulation.

    Directory of Open Access Journals (Sweden)

    Ed VanBavel

    Full Text Available Organ perfusion is regulated by vasoactivity and structural adaptation of small arteries and arterioles. These resistance vessels are sensitive to pressure, flow and a range of vasoactive stimuli. Several strongly interacting control loops exist. As an example, the myogenic response to a change of pressure influences the endothelial shear stress, thereby altering the contribution of shear-dependent dilation to the vascular tone. In addition, acute responses change the stimulus for structural adaptation and vice versa. Such control loops are able to maintain resistance vessels in a functional and stable state, characterized by regulated wall stress, shear stress, matched active and passive biomechanics and presence of vascular reserve. In this modeling study, four adaptation processes are identified that together with biomechanical properties effectuate such integrated regulation: control of tone, smooth muscle cell length adaptation, eutrophic matrix rearrangement and trophic responses. Their combined action maintains arteries in their optimal state, ready to cope with new challenges, allowing continuous long-term vasoregulation. The exclusion of any of these processes results in a poorly regulated state and in some cases instability of vascular structure.

  10. Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy

    Directory of Open Access Journals (Sweden)

    Qiaoli Li

    2013-09-01

    Generalized arterial calcification of infancy (GACI, an autosomal recessive disorder, is characterized by early mineralization of blood vessels, often diagnosed by prenatal ultrasound and usually resulting in demise during the first year of life. It is caused in most cases by mutations in the ENPP1 gene, encoding an enzyme that hydrolyzes ATP to AMP and inorganic pyrophosphate, the latter being a powerful anti-mineralization factor. Recently, a novel mouse phenotype was recognized as a result of ENU mutagenesis – those mice developed stiffening of the joints, hence the mutant mouse was named ‘ages with stiffened joints’ (asj. These mice harbor a missense mutation, p.V246D, in the Enpp1 gene. Here we demonstrate that the mutant ENPP1 protein is largely absent in the liver of asj mice, and the lack of enzymatic activity results in reduced inorganic pyrophosphate (PPi levels in the plasma, accompanied by extensive mineralization of a number of tissues, including arterial blood vessels. The progress of mineralization is highly dependent on the mineral composition of the diet, with significant shortening of the lifespan on a diet enriched in phosphorus and low in magnesium. These results suggest that the asj mouse can serve as an animal model for GACI.

  11. Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy.

    Science.gov (United States)

    Li, Qiaoli; Guo, Haitao; Chou, David W; Berndt, Annerose; Sundberg, John P; Uitto, Jouni

    2013-09-01

    Generalized arterial calcification of infancy (GACI), an autosomal recessive disorder, is characterized by early mineralization of blood vessels, often diagnosed by prenatal ultrasound and usually resulting in demise during the first year of life. It is caused in most cases by mutations in the ENPP1 gene, encoding an enzyme that hydrolyzes ATP to AMP and inorganic pyrophosphate, the latter being a powerful anti-mineralization factor. Recently, a novel mouse phenotype was recognized as a result of ENU mutagenesis - those mice developed stiffening of the joints, hence the mutant mouse was named 'ages with stiffened joints' (asj). These mice harbor a missense mutation, p.V246D, in the Enpp1 gene. Here we demonstrate that the mutant ENPP1 protein is largely absent in the liver of asj mice, and the lack of enzymatic activity results in reduced inorganic pyrophosphate (PPi) levels in the plasma, accompanied by extensive mineralization of a number of tissues, including arterial blood vessels. The progress of mineralization is highly dependent on the mineral composition of the diet, with significant shortening of the lifespan on a diet enriched in phosphorus and low in magnesium. These results suggest that the asj mouse can serve as an animal model for GACI.

  12. A model for investigating the control of muscle blood flow: the masseteric artery in conscious rabbits.

    Science.gov (United States)

    Roatta, S; Mohammed, M; Turturici, M; Milano, L; Passatore, M

    2010-09-01

    The complex interplay of neural, metabolic, myogenic and mechanical mechanisms that regulate blood flow in skeletal muscle (MBF) is still incompletely understood. For the first time, a method is presented for high time-resolution recording of MBF from a purely muscular artery in physiological conditions. Ultrasound perivascular flow probes were implanted (n = 15) mono- or bilaterally around the masseteric branch of the facial artery in nine rabbits and tested up to 16 days after implant. Reliable and stable recordings were achieved in 50% of implants. Blood flow was observed to increase from a resting level of 0.2-0.3 ml min(-1) up to 4.0-6.0 ml min(-1) during spontaneous masticatory activity. In addition, within single masticatory cycles marked back flow transients could be observed (peak flow = -10 ml min(-1)) during powerful masticatory strokes but not during mild mastication. The possibility of (1) surgically removing the sympathetic supply to the relevant vascular bed and of (2) bilaterally monitoring the perfusion of masseter muscles thus allowing to use one side as control side for different types of interventions makes this model a useful tool for disentangling the different mechanisms involved in the control of MBF.

  13. Application of neural network model coupling with the partial least-squares method for forecasting watre yield of mine

    Institute of Scientific and Technical Information of China (English)

    CHEN Nan-xiang; CAO Lian-hai; HUANG Qiang

    2005-01-01

    Scientific forecasting water yield of mine is of great significance to the safety production of mine and the colligated using of water resources. The paper established the forecasting model for water yield of mine, combining neural network with the partial least square method. Dealt with independent variables by the partial least square method, it can not only solve the relationship between independent variables but also reduce the input dimensions in neural network model, and then use the neural network which can solve the non-linear problem better. The result of an example shows that the prediction has higher precision in forecasting and fitting.

  14. Early retinal inflammatory biomarkers in the middle cerebral artery occlusion model of ischemic stroke

    Science.gov (United States)

    Ritzel, Rodney M.; Pan, Sarah J.; Verma, Rajkumar; Wizeman, John; Crapser, Joshua; Patel, Anita R.; Lieberman, Richard; Mohan, Royce

    2016-01-01

    Purpose The transient middle cerebral artery occlusion (MCAO) model of stroke is one of the most commonly used models to study focal cerebral ischemia. This procedure also results in the simultaneous occlusion of the ophthalmic artery that supplies the retina. Retinal cell death is seen days after reperfusion and leads to functional deficits; however, the mechanism responsible for this injury has not been investigated. Given that the eye may have a unique ocular immune response to an ischemic challenge, this study examined the inflammatory response to retinal ischemia in the MCAO model. Methods Young male C57B/6 mice were subjected to 90-min transient MCAO and were euthanized at several time points up to 7 days. Transcription of inflammatory cytokines was measured with quantitative real-time PCR, and immune cell activation (e.g., phagocytosis) and migration were assessed with ophthalmoscopy and flow cytometry. Results Observation of the affected eye revealed symptoms consistent with Horner’s syndrome. Light ophthalmoscopy confirmed the reduced blood flow of the retinal arteries during occlusion. CX3CR1-GFP reporter mice were then employed to evaluate the extent of the ocular microglia and monocyte activation. A significant increase in green fluorescent protein (GFP)-positive macrophages was seen throughout the ischemic area compared to the sham and contralateral control eyes. RT–PCR revealed enhanced expression of the monocyte chemotactic molecule CCL2 early after reperfusion followed by a delayed increase in the proinflammatory cytokine TNF-α. Further analysis of peripheral leukocyte recruitment by flow cytometry determined that monocytes and neutrophils were the predominant immune cells to infiltrate at 72 h. A transient reduction in retinal microglia numbers was also observed, demonstrating the ischemic sensitivity of these cells. Blood–eye barrier permeability to small and large tracer molecules was increased by 72 h. Retinal microglia exhibited enhanced

  15. Infliximab partially alleviates the bite force reduction in a mouse model of temporomandibular joint pain.

    Science.gov (United States)

    Kim, Sang-Hyon; Son, Chang-Nam; Lee, Hyo-Jung; Cho, Ho-Chan; Jung, Sung-Won; Hur, Ji An; Baek, Won-Ki; Jung, Hye Ra; Hong, Ji Hee

    2015-05-01

    Temporomandibular joint (TMJ) disorder is clinically important because of its prevalence, chronicity, and therapy-refractoriness of the pain. In this study, we investigated the effect of infliximab in a mouse model of TMJ pain using a specially-engineered transducer for evaluating the changes in bite force (BF). The mice were randomly divided into three groups (7 mice per group): the control group, the complete Freund's adjuvant (CFA) group, and the infliximab group. BF was measured at day 0 (baseline BF). After measuring the baseline BF, CFA or incomplete Freund's adjuvant was injected into both TMJs and then the changes in BF were measured at days 1, 3, 5, 7, 9, and 13 after the TMJ injection. For measuring the BF, we used a custom-built BF transducer. Control, CFA, and infliximab groups showed similar baseline BF at day 0. From day 1, a significant reduction in BF was observed in the CFA group, and this reduction in BF was statistically significant compared to that in the control group (P infliximab group also, the reduction in BF was observed on day 1, and this reduction was maintained until day 7. However, the degree of reduction in BF was less remarkable compared to that in the CFA group. The reduction in BF caused by injection of CFA into the TMJ could be partially alleviated by the injection of anti-tumor necrosis factor alpha, infliximab.

  16. The structure of radiative shock waves. III. The model grid for partially ionized hydrogen gas

    CERN Document Server

    Fadeyev, Y A; Fadeyev, Yu. A.

    2001-01-01

    The grid of the models of radiative shock waves propagating through partially ionized hydrogen gas with temperature 3000K <= T_1 <= 8000K and density 10^{-12} gm/cm^3 <= \\rho_1 <= 10^{-9}gm/cm^3 is computed for shock velocities 20 km/s <= U_1 <= 90 km/s. The fraction of the total energy of the shock wave irreversibly lost due to radiation flux ranges from 0.3 to 0.8 for 20 km/s <= U_1 <= 70 km/s. The postshock gas is compressed mostly due to radiative cooling in the hydrogen recombination zone and final compression ratios are within 1 <\\rho_N/\\rho_1 \\lesssim 10^2, depending mostly on the shock velocity U_1. The preshock gas temperature affects the shock wave structure due to the equilibrium ionization of the unperturbed hydrogen gas, since the rates of postshock relaxation processes are very sensitive to the number density of hydrogen ions ahead the discontinuous jump. Both the increase of the preshock gas temperature and the decrease of the preshock gas density lead to lower postsh...

  17. Apparent-contact-angle model at partial wetting and evaporation: Impact of surface forces

    Science.gov (United States)

    Janeček, V.; Nikolayev, V. S.

    2013-01-01

    This theoretical and numerical study deals with evaporation of a fluid wedge in contact with its pure vapor. The model describes a regime where the continuous wetting film is absent and the actual line of the triple gas-liquid-solid contact appears. A constant temperature higher than the saturation temperature is imposed at the solid substrate. The fluid flow is solved in the lubrication approximation. The introduction of the surface forces in the case of the partial wetting is discussed. The apparent contact angle (the gas-liquid interface slope far from the contact line) is studied numerically as a function of the substrate superheating, contact line velocity, and parameters related to the solid-fluid interaction (Young and microscopic contact angles, Hamaker constant, etc.). The dependence of the apparent contact angle on the substrate temperature is in agreement with existing approaches. For water, the apparent contact angle may be 20∘ larger than the Young contact angle for 1 K superheating. The effect of the surface forces on the apparent contact angle is found to be weak.

  18. Assessment of Deep Partial Thickness Burn Treatment with Keratin Biomaterial Hydrogels in a Swine Model

    Directory of Open Access Journals (Sweden)

    D. Poranki

    2016-01-01

    Full Text Available Partial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified keratin hydrogel could reduce burn wound progression and speed healing. Standardized burn wounds were created in Yorkshire swine and treated within 30 minutes with keratin hydrogel (modified and unmodified, collagen hydrogel, or silver sulfadiazine (SSD. Digital images of each wound were taken for area measurements immediately prior to cleaning and dressing changes. Wound tissue was collected and assessed histologically at several time points. Wound area showed a significant difference between hydrogels and SSD groups, and rates of reepithelialization at early time points showed an increase when keratin treatment was used compared to both collagen and SSD. A linear regression model predicted a time to wound closure of approximately 25 days for keratin hydrogel while SSD treatment required 35 days. There appeared to be no measurable differences between the modified and unmodified formulations of keratin hydrogels.

  19. Human activated protein C variants in a rat model of arterial thrombosis

    Directory of Open Access Journals (Sweden)

    Dahlbäck Björn

    2008-10-01

    Full Text Available Abstract Background Activated protein C (APC inhibits coagulation by degrading activated factor V (FVa and factor VIII (FVIIIa, protein S (PS functioning as a cofactor to APC. Methods By mutagenesis of the vitamin K-dependent Gla domain of APC, we have recently created an APC variant having enhanced anticoagulant activity due to increased affinity for negatively charged phospholipid membranes. In the present study, the potential antithrombotic effects of this APC variant, and of a variant APC that is additionally mutated in the serine protease domain, have been evaluated in a blind randomized study in a rat model of arterial thrombosis. In this model, we have previously found the combination of bovine APC and PS to be highly antithrombotic. Four treatment groups each containing 10 rats were, in a blind random fashion, given intravenous bolus injections of wild-type or mutant variants of APC (0.8 mg/kg together with human PS (0.6 mg/kg or human PS (0.6 mg/kg alone. A control group with 20 animals where given vehicle only. Results A trend to increased patency rates was noted in a group receiving one of the APC variants, but it did not reach statistical significance. Conclusion In conclusion, administration of human APC variants having enhanced anticoagulant efficacy together with human PS in a rat model of arterial thrombosis did not give an efficient antithrombotic effect. The lack of effect may be due to species-specific differences between the human protein C system and the rat hemostatic system.

  20. Impact of blood rheology on wall shear stress in a model of the middle cerebral artery

    Science.gov (United States)

    Bernabeu, Miguel O.; Nash, Rupert W.; Groen, Derek; Carver, Hywel B.; Hetherington, James; Krüger, Timm; Coveney, Peter V.

    2013-01-01

    Perturbations to the homeostatic distribution of mechanical forces exerted by blood on the endothelial layer have been correlated with vascular pathologies, including intracranial aneurysms and atherosclerosis. Recent computational work suggests that, in order to correctly characterize such forces, the shear-thinning properties of blood must be taken into account. To the best of our knowledge, these findings have never been compared against experimentally observed pathological thresholds. In this work, we apply the three-band diagram (TBD) analysis due to Gizzi et al. (Gizzi et al. 2011 Three-band decomposition analysis of wall shear stress in pulsatile flows. Phys. Rev. E 83, 031902. (doi:10.1103/PhysRevE.83.031902)) to assess the impact of the choice of blood rheology model on a computational model of the right middle cerebral artery. Our results show that, in the model under study, the differences between the wall shear stress predicted by a Newtonian model and the well-known Carreau–Yasuda generalized Newtonian model are only significant if the vascular pathology under study is associated with a pathological threshold in the range 0.94–1.56 Pa, where the results of the TBD analysis of the rheology models considered differs. Otherwise, we observe no significant differences. PMID:24427534