WorldWideScience

Sample records for modeling approach integrating

  1. Pedagogic process modeling: Humanistic-integrative approach

    Directory of Open Access Journals (Sweden)

    Boritko Nikolaj M.

    2007-01-01

    Full Text Available The paper deals with some current problems of modeling the dynamics of the subject-features development of the individual. The term "process" is considered in the context of the humanistic-integrative approach, in which the principles of self education are regarded as criteria for efficient pedagogic activity. Four basic characteristics of the pedagogic process are pointed out: intentionality reflects logicality and regularity of the development of the process; discreteness (stageability in dicates qualitative stages through which the pedagogic phenomenon passes; nonlinearity explains the crisis character of pedagogic processes and reveals inner factors of self-development; situationality requires a selection of pedagogic conditions in accordance with the inner factors, which would enable steering the pedagogic process. Offered are two steps for singling out a particular stage and the algorithm for developing an integrative model for it. The suggested conclusions might be of use for further theoretic research, analyses of educational practices and for realistic predicting of pedagogical phenomena. .

  2. MODELS OF TECHNOLOGY ADOPTION: AN INTEGRATIVE APPROACH

    Directory of Open Access Journals (Sweden)

    Andrei OGREZEANU

    2015-06-01

    Full Text Available The interdisciplinary study of information technology adoption has developed rapidly over the last 30 years. Various theoretical models have been developed and applied such as: the Technology Acceptance Model (TAM, Innovation Diffusion Theory (IDT, Theory of Planned Behavior (TPB, etc. The result of these many years of research is thousands of contributions to the field, which, however, remain highly fragmented. This paper develops a theoretical model of technology adoption by integrating major theories in the field: primarily IDT, TAM, and TPB. To do so while avoiding mess, an approach that goes back to basics in independent variable type’s development is proposed; emphasizing: 1 the logic of classification, and 2 psychological mechanisms behind variable types. Once developed these types are then populated with variables originating in empirical research. Conclusions are developed on which types are underpopulated and present potential for future research. I end with a set of methodological recommendations for future application of the model.

  3. Integration models: multicultural and liberal approaches confronted

    Science.gov (United States)

    Janicki, Wojciech

    2012-01-01

    European societies have been shaped by their Christian past, upsurge of international migration, democratic rule and liberal tradition rooted in religious tolerance. Boosting globalization processes impose new challenges on European societies, striving to protect their diversity. This struggle is especially clearly visible in case of minorities trying to resist melting into mainstream culture. European countries' legal systems and cultural policies respond to these efforts in many ways. Respecting identity politics-driven group rights seems to be the most common approach, resulting in creation of a multicultural society. However, the outcome of respecting group rights may be remarkably contradictory to both individual rights growing out from liberal tradition, and to reinforced concept of integration of immigrants into host societies. The hereby paper discusses identity politics upturn in the context of both individual rights and integration of European societies.

  4. Development of Multisensory Integration Approach Model

    Science.gov (United States)

    Kumar, S. Prasanna; Nathan, B. Sami

    2016-01-01

    Every teacher expects optimum level of processing in mind of them students. The level of processing is mainly depends upon memory process. Most of the students have retrieval difficulties on past learning. Memory difficulties directly related to sensory integration. In these circumstances the investigator made an attempt to construct Multisensory…

  5. An Integrated Approach to Modeling Evacuation Behavior

    Science.gov (United States)

    2011-02-01

    A spate of recent hurricanes and other natural disasters have drawn a lot of attention to the evacuation decision of individuals. Here we focus on evacuation models that incorporate two economic phenomena that seem to be increasingly important in exp...

  6. Challenges and opportunities for integrating lake ecosystem modelling approaches

    Science.gov (United States)

    Mooij, Wolf M.; Trolle, Dennis; Jeppesen, Erik; Arhonditsis, George; Belolipetsky, Pavel V.; Chitamwebwa, Deonatus B.R.; Degermendzhy, Andrey G.; DeAngelis, Donald L.; Domis, Lisette N. De Senerpont; Downing, Andrea S.; Elliott, J. Alex; Ruberto, Carlos Ruberto; Gaedke, Ursula; Genova, Svetlana N.; Gulati, Ramesh D.; Hakanson, Lars; Hamilton, David P.; Hipsey, Matthew R.; Hoen, Jochem 't; Hulsmann, Stephan; Los, F. Hans; Makler-Pick, Vardit; Petzoldt, Thomas; Prokopkin, Igor G.; Rinke, Karsten; Schep, Sebastiaan A.; Tominaga, Koji; Van Dam, Anne A.; Van Nes, Egbert H.; Wells, Scott A.; Janse, Jan H.

    2010-01-01

    A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing the wheel'). The other challenge is to avoid focusing on only one type of model, while ignoring new and diverse approaches that have become available ('having tunnel vision'). In this paper, we aim at improving the awareness of existing models and knowledge of concurrent approaches in lake ecosystem modelling, without covering all possible model tools and avenues. First, we present a broad variety of modelling approaches. To illustrate these approaches, we give brief descriptions of rather arbitrarily selected sets of specific models. We deal with static models (steady state and regression models), complex dynamic models (CAEDYM, CE-QUAL-W2, Delft 3D-ECO, LakeMab, LakeWeb, MyLake, PCLake, PROTECH, SALMO), structurally dynamic models and minimal dynamic models. We also discuss a group of approaches that could all be classified as individual based: super-individual models (Piscator, Charisma), physiologically structured models, stage-structured models and trait-based models. We briefly mention genetic algorithms, neural networks, Kalman filters and fuzzy logic. Thereafter, we zoom in, as an in-depth example, on the multi-decadal development and application of the lake ecosystem model PCLake and related models (PCLake Metamodel, Lake Shira Model, IPH-TRIM3D-PCLake). In the discussion, we argue that while the historical development of each approach and model is understandable given its 'leading principle', there are many opportunities for combining approaches. We take the point of view that a single 'right' approach does not exist and should not be strived for. Instead, multiple modelling approaches, applied concurrently to a given problem, can help develop an integrative

  7. An integrated modeling approach to age invariant face recognition

    Science.gov (United States)

    Alvi, Fahad Bashir; Pears, Russel

    2015-03-01

    This Research study proposes a novel method for face recognition based on Anthropometric features that make use of an integrated approach comprising of a global and personalized models. The system is aimed to at situations where lighting, illumination, and pose variations cause problems in face recognition. A Personalized model covers the individual aging patterns while a Global model captures general aging patterns in the database. We introduced a de-aging factor that de-ages each individual in the database test and training sets. We used the k nearest neighbor approach for building a personalized model and global model. Regression analysis was applied to build the models. During the test phase, we resort to voting on different features. We used FG-Net database for checking the results of our technique and achieved 65 percent Rank 1 identification rate.

  8. Vertically-integrated Approaches for Carbon Sequestration Modeling

    Science.gov (United States)

    Bandilla, K.; Celia, M. A.; Guo, B.

    2015-12-01

    Carbon capture and sequestration (CCS) is being considered as an approach to mitigate anthropogenic CO2 emissions from large stationary sources such as coal fired power plants and natural gas processing plants. Computer modeling is an essential tool for site design and operational planning as it allows prediction of the pressure response as well as the migration of both CO2 and brine in the subsurface. Many processes, such as buoyancy, hysteresis, geomechanics and geochemistry, can have important impacts on the system. While all of the processes can be taken into account simultaneously, the resulting models are computationally very expensive and require large numbers of parameters which are often uncertain or unknown. In many cases of practical interest, the computational and data requirements can be reduced by choosing a smaller domain and/or by neglecting or simplifying certain processes. This leads to a series of models with different complexity, ranging from coupled multi-physics, multi-phase three-dimensional models to semi-analytical single-phase models. Under certain conditions the three-dimensional equations can be integrated in the vertical direction, leading to a suite of two-dimensional multi-phase models, termed vertically-integrated models. These models are either solved numerically or simplified further (e.g., assumption of vertical equilibrium) to allow analytical or semi-analytical solutions. This presentation focuses on how different vertically-integrated models have been applied to the simulation of CO2 and brine migration during CCS projects. Several example sites, such as the Illinois Basin and the Wabamun Lake region of the Alberta Basin, are discussed to show how vertically-integrated models can be used to gain understanding of CCS operations.

  9. Modeling fabrication of nuclear components: An integrative approach

    Energy Technology Data Exchange (ETDEWEB)

    Hench, K.W.

    1996-08-01

    Reduction of the nuclear weapons stockpile and the general downsizing of the nuclear weapons complex has presented challenges for Los Alamos. One is to design an optimized fabrication facility to manufacture nuclear weapon primary components in an environment of intense regulation and shrinking budgets. This dissertation presents an integrative two-stage approach to modeling the casting operation for fabrication of nuclear weapon primary components. The first stage optimizes personnel radiation exposure for the casting operation layout by modeling the operation as a facility layout problem formulated as a quadratic assignment problem. The solution procedure uses an evolutionary heuristic technique. The best solutions to the layout problem are used as input to the second stage - a simulation model that assesses the impact of competing layouts on operational performance. The focus of the simulation model is to determine the layout that minimizes personnel radiation exposures and nuclear material movement, and maximizes the utilization of capacity for finished units.

  10. A path integral approach to the Hodgkin-Huxley model

    Science.gov (United States)

    Baravalle, Roman; Rosso, Osvaldo A.; Montani, Fernando

    2017-11-01

    To understand how single neurons process sensory information, it is necessary to develop suitable stochastic models to describe the response variability of the recorded spike trains. Spikes in a given neuron are produced by the synergistic action of sodium and potassium of the voltage-dependent channels that open or close the gates. Hodgkin and Huxley (HH) equations describe the ionic mechanisms underlying the initiation and propagation of action potentials, through a set of nonlinear ordinary differential equations that approximate the electrical characteristics of the excitable cell. Path integral provides an adequate approach to compute quantities such as transition probabilities, and any stochastic system can be expressed in terms of this methodology. We use the technique of path integrals to determine the analytical solution driven by a non-Gaussian colored noise when considering the HH equations as a stochastic system. The different neuronal dynamics are investigated by estimating the path integral solutions driven by a non-Gaussian colored noise q. More specifically we take into account the correlational structures of the complex neuronal signals not just by estimating the transition probability associated to the Gaussian approach of the stochastic HH equations, but instead considering much more subtle processes accounting for the non-Gaussian noise that could be induced by the surrounding neural network and by feedforward correlations. This allows us to investigate the underlying dynamics of the neural system when different scenarios of noise correlations are considered.

  11. Social Network Analyses and Nutritional Behavior: An Integrated Modeling Approach

    Directory of Open Access Journals (Sweden)

    Alistair McNair Senior

    2016-01-01

    Full Text Available Animals have evolved complex foraging strategies to obtain a nutritionally balanced diet and associated fitness benefits. Recent advances in nutrition research, combining state-space models of nutritional geometry with agent-based models of systems biology, show how nutrient targeted foraging behavior can also influence animal social interactions, ultimately affecting collective dynamics and group structures. Here we demonstrate how social network analyses can be integrated into such a modeling framework and provide a tangible and practical analytical tool to compare experimental results with theory. We illustrate our approach by examining the case of nutritionally mediated dominance hierarchies. First we show how nutritionally explicit agent-based models that simulate the emergence of dominance hierarchies can be used to generate social networks. Importantly the structural properties of our simulated networks bear similarities to dominance networks of real animals (where conflicts are not always directly related to nutrition. Finally, we demonstrate how metrics from social network analyses can be used to predict the fitness of agents in these simulated competitive environments. Our results highlight the potential importance of nutritional mechanisms in shaping dominance interactions in a wide range of social and ecological contexts. Nutrition likely influences social interaction in many species, and yet a theoretical framework for exploring these effects is currently lacking. Combining social network analyses with computational models from nutritional ecology may bridge this divide, representing a pragmatic approach for generating theoretical predictions for nutritional experiments.

  12. Social Network Analysis and Nutritional Behavior: An Integrated Modeling Approach.

    Science.gov (United States)

    Senior, Alistair M; Lihoreau, Mathieu; Buhl, Jerome; Raubenheimer, David; Simpson, Stephen J

    2016-01-01

    Animals have evolved complex foraging strategies to obtain a nutritionally balanced diet and associated fitness benefits. Recent research combining state-space models of nutritional geometry with agent-based models (ABMs), show how nutrient targeted foraging behavior can also influence animal social interactions, ultimately affecting collective dynamics and group structures. Here we demonstrate how social network analyses can be integrated into such a modeling framework and provide a practical analytical tool to compare experimental results with theory. We illustrate our approach by examining the case of nutritionally mediated dominance hierarchies. First we show how nutritionally explicit ABMs that simulate the emergence of dominance hierarchies can be used to generate social networks. Importantly the structural properties of our simulated networks bear similarities to dominance networks of real animals (where conflicts are not always directly related to nutrition). Finally, we demonstrate how metrics from social network analyses can be used to predict the fitness of agents in these simulated competitive environments. Our results highlight the potential importance of nutritional mechanisms in shaping dominance interactions in a wide range of social and ecological contexts. Nutrition likely influences social interactions in many species, and yet a theoretical framework for exploring these effects is currently lacking. Combining social network analyses with computational models from nutritional ecology may bridge this divide, representing a pragmatic approach for generating theoretical predictions for nutritional experiments.

  13. Integration of measurement data in the comprehensive modelling approach

    Science.gov (United States)

    Sieber, I.; Rübenach, O.

    2013-09-01

    Efficient and reliable optical design requires knowledge of the production chain, the materials used, and the environmental circumstances in the field of operation. This is realized in the comprehensive modelling approach consisting of three steps: • Design for manufacturing, i.e. the model must be adjusted to the process chain. Knowledge of design rules is required. • Robust design, i.e. optimization of the functional design with the objective of a compensation of the tolerance influences on the system's performance. Knowledge of the tolerances of the individual process steps is required. • Reliable design with respect to environmental and operational effects, respectively. Coupling of an optical and mechanical simulation tool is required to form the optical simulation environment. The availability of process knowledge such as e.g. design rules and manufacturing tolerances is ensured by coupling of the optical simulation environment with a process knowledge database. Integration of measured surface data in this simulation environment enables a realistic simulation and analysis of real, manufactured optics. This approach allows e.g. for the evaluation of replication methods such as precision molding or injection molding against high-precision manufacturing methods, e.g. diamond turning.

  14. Integrated design approach of the pebble bed modular using models

    International Nuclear Information System (INIS)

    Venter, P.J.

    2005-01-01

    The Pebble Bed Modular Reactor (PBMR) is the first pebble bed reactor that will be utilised in a high temperature direct Brayton cycle configuration. This implies that there are a number of unique features in the PBMR that extend from the German experience base. One of the challenges in the design of the PBMR is managing the integrated design process between the designers, the physicists and the analysts. This integrated design process is managed through model-based development work. Three-dimensional CAD models are constructed of the components and parts in the reactor. From the CAD models, CFD models, neutronic models, shielding models, FEM models and other thermodynamic models are derived. These models range from very simple models to extremely detailed and complex models. The models are used in legacy software as well as commercial off-the-shelf software. The different models are also used in code-to-code comparisons to verify the results. This paper will briefly discuss the different models and the interaction between the models, showing the iterative design process that is used in the development of the reactor at PBMR. (author)

  15. An Almost Integration-free Approach to Ordered Response Models

    NARCIS (Netherlands)

    van Praag, B.M.S.; Ferrer-i-Carbonell, A.

    2006-01-01

    'In this paper we propose an alternative approach to the estimation of ordered response models. We show that the Probit-method may be replaced by a simple OLS-approach, called P(robit)OLS, without any loss of efficiency. This method can be generalized to the analysis of panel data. For large-scale

  16. Sodium balance-an integrated physiological model and novel approach

    OpenAIRE

    Patel Santosh

    2009-01-01

    Various physiological mechanisms regulate sodium and water balance in the human body. These processes achieve acute and chronic sodium regulation and the simultaneous or se-quential changes can be explained using a single physiological model. Steady intracellular water and osmolality is necessary for cell membrane integrity and cellular processes. Body fluids protect circulatory blood volume by altering Na + and water balance. This is the most vital homeostatic function of the body. C...

  17. Integrated healthcare networks' performance: a growth curve modeling approach.

    Science.gov (United States)

    Wan, Thomas T H; Wang, Bill B L

    2003-05-01

    This study examines the effects of integration on the performance ratings of the top 100 integrated healthcare networks (IHNs) in the United States. A strategic-contingency theory is used to identify the relationship of IHNs' performance to their structural and operational characteristics and integration strategies. To create a database for the panel study, the top 100 IHNs selected by the SMG Marketing Group in 1998 were followed up in 1999 and 2000. The data were merged with the Dorenfest data on information system integration. A growth curve model was developed and validated by the Mplus statistical program. Factors influencing the top 100 IHNs' performance in 1998 and their subsequent rankings in the consecutive years were analyzed. IHNs' initial performance scores were positively influenced by network size, number of affiliated physicians and profit margin, and were negatively associated with average length of stay and technical efficiency. The continuing high performance, judged by maintaining higher performance scores, tended to be enhanced by the use of more managerial or executive decision-support systems. Future studies should include time-varying operational indicators to serve as predictors of network performance.

  18. Understanding Gulf War Illness: An Integrative Modeling Approach

    Science.gov (United States)

    2017-10-01

    high-order diffusion imaging in a rat model of Gulf War Illness. §These authors contributed equally to the work. Brain Behavior and Immunity. pii...astrocyte specific transcriptome responses to neurotoxicity. §These authors contributed equally to the work. Submitted for Internal CDC-NIOSH...Antagonist: Evaluation of Beneficial Effects for Gulf War Illness 4) GW160116 (Nathanson) Genomics approach to find gender specific mechanisms of GWI

  19. The Integrated Gateway Model: a catalytic approach to behavior change.

    Science.gov (United States)

    Schwandt, Hilary M; Skinner, Joanna; Takruri, Adel; Storey, Douglas

    2015-08-01

    To develop and test an Integrated Gateway Model of behaviors and factors leading to subsequent positive reproductive, maternal, and child health behaviors. A secondary analysis was conducted using previously published household survey data collected from men (n=5551; 2011) and women (n=16144; 2011) in Nigeria and women in Egypt (n=2240; 2004-2007). The number of health behaviors each potential gateway behavior predicted was assessed by multivariate regression, adjusting for potential confounders. The influence of gateway factors on gateway behaviors was tested via interaction terms. Gateway behaviors and factors were ranked by the number of health outcomes predicted, both separately and synergistically. The key gateway behavior identified in both datasets was spousal communication about family planning, whereas the key gateway factor was exposure to family planning messages. The model could facilitate innovative research and programming that in turn might promote cascades of positive behaviors in reproductive, maternal, and child health. Copyright © 2015. Published by Elsevier Ireland Ltd.

  20. Leader communication approaches and patient safety: An integrated model.

    Science.gov (United States)

    Mattson, Malin; Hellgren, Johnny; Göransson, Sara

    2015-06-01

    Leader communication is known to influence a number of employee behaviors. When it comes to the relationship between leader communication and safety, the evidence is more scarce and ambiguous. The aim of the present study is to investigate whether and in what way leader communication relates to safety outcomes. The study examines two leader communication approaches: leader safety priority communication and feedback to subordinates. These approaches were assumed to affect safety outcomes via different employee behaviors. Questionnaire data, collected from 221 employees at two hospital wards, were analyzed using structural equation modeling. The two examined communication approaches were both positively related to safety outcomes, although leader safety priority communication was mediated by employee compliance and feedback communication by organizational citizenship behaviors. The findings suggest that leader communication plays a vital role in improving organizational and patient safety and that different communication approaches seem to positively affect different but equally essential employee safety behaviors. The results highlights the necessity for leaders to engage in one-way communication of safety values as well as in more relational feedback communication with their subordinates in order to enhance patient safety. Copyright © 2015 Elsevier Ltd. and National Safety Council. Published by Elsevier Ltd. All rights reserved.

  1. Sodium balance-an integrated physiological model and novel approach

    Directory of Open Access Journals (Sweden)

    Patel Santosh

    2009-01-01

    Full Text Available Various physiological mechanisms regulate sodium and water balance in the human body. These processes achieve acute and chronic sodium regulation and the simultaneous or se-quential changes can be explained using a single physiological model. Steady intracellular water and osmolality is necessary for cell membrane integrity and cellular processes. Body fluids protect circulatory blood volume by altering Na + and water balance. This is the most vital homeostatic function of the body. Changes in ECF volume are sensed by various cardinal sensors. Physio-logically, the main aim of Na + and water balance is to permit variable salt and water intake without large fluctuations in blood pressure or volume status. Homeostatic processes act in an integrated fashion to protect against any perturbations. Characteristically, these mechanisms are sequential as well as parallel. These may be synergistic or antagonistic to each other. Rapidity, sensitivity and potency of these powerful feedback systems differ. Various physiological and pathological insults determine the magnitude of response of these systems.

  2. Using graph approach for managing connectivity in integrative landscape modelling

    Science.gov (United States)

    Rabotin, Michael; Fabre, Jean-Christophe; Libres, Aline; Lagacherie, Philippe; Crevoisier, David; Moussa, Roger

    2013-04-01

    In cultivated landscapes, a lot of landscape elements such as field boundaries, ditches or banks strongly impact water flows, mass and energy fluxes. At the watershed scale, these impacts are strongly conditionned by the connectivity of these landscape elements. An accurate representation of these elements and of their complex spatial arrangements is therefore of great importance for modelling and predicting these impacts.We developped in the framework of the OpenFLUID platform (Software Environment for Modelling Fluxes in Landscapes) a digital landscape representation that takes into account the spatial variabilities and connectivities of diverse landscape elements through the application of the graph theory concepts. The proposed landscape representation consider spatial units connected together to represent the flux exchanges or any other information exchanges. Each spatial unit of the landscape is represented as a node of a graph and relations between units as graph connections. The connections are of two types - parent-child connection and up/downstream connection - which allows OpenFLUID to handle hierarchical graphs. Connections can also carry informations and graph evolution during simulation is possible (connections or elements modifications). This graph approach allows a better genericity on landscape representation, a management of complex connections and facilitate development of new landscape representation algorithms. Graph management is fully operational in OpenFLUID for developers or modelers ; and several graph tools are available such as graph traversal algorithms or graph displays. Graph representation can be managed i) manually by the user (for example in simple catchments) through XML-based files in easily editable and readable format or ii) by using methods of the OpenFLUID-landr library which is an OpenFLUID library relying on common open-source spatial libraries (ogr vector, geos topologic vector and gdal raster libraries). Open

  3. Climate change and malaria risk: An integrated modelling approach

    Energy Technology Data Exchange (ETDEWEB)

    Martens, W.J.M.; Rotmans, J.; Niessen, L.W. (RIVM Global Modelling and Sustainable Development Group and Environmental Forecasting Bureau, Bilthoven (Netherlands))

    1994-05-01

    In order to assess the impact of an anthropogenic climate change on the transmission of malaria, an integrated assessment model has been developed. In the model the direct effects of a change in temperature and precipitation on the transmission potential of a mosquito population are assessed by means of the vectorial capacity (the number of potentially infected contacts inflicted by the mosquito population per infectious person per day) and the related critical mosquito density. The most important parameters of the vectorial capacity and critical mosquito density are: the longevity of the mosquito, the frequency of taking blood meals from humans and the duration of the development of the parasite inside the mosquito. The effect of a human-induced climate change on human health is evaluated by assessing the change in malaria prevalence and disease burden. A sustainable development index, which is an aggregate of an environmental pressure indicator, a health indicator and a socio-economic development indicator is introduced and discussed. Such an index can be used to determine whether future projections are sustainable. The simulation results indicate a worldwide increase of potential malaria risk and an extension of the areas conducive to malaria transmission. In the endemic malarious areas of the tropics and subtropics, malaria prevalence and consequently the number of years of healthy life lost due to malaria may increase. The rate of temperature change is also expected to exceed the recommended target level of 0.1[degree]C per decade. In non-malarious areas the risk of introduction of malaria associated with imported cases of malaria increases to some extent as a result of the increasing importance of modern transport systems (e.g. air travel) in introducing malaria into receptive areas. However, sound interpretation of the change in malaria risk as simulated must be performed within the framework of local conditions.

  4. An integrated chronic disease management model: a diagonal approach to health system strengthening in South Africa.

    Science.gov (United States)

    Mahomed, Ozayr Haroon; Asmall, Shaidah; Freeman, Melvyn

    2014-11-01

    The integrated chronic disease management model provides a systematic framework for creating a fundamental change in the orientation of the health system. This model adopts a diagonal approach to health system strengthening by establishing a service-linked base to training, supervision, and the opportunity to try out, assess, and implement integrated interventions.

  5. Integrating Modelling Approaches for Understanding Telecoupling: Global Food Trade and Local Land Use

    Directory of Open Access Journals (Sweden)

    James D. A. Millington

    2017-08-01

    Full Text Available The telecoupling framework is an integrated concept that emphasises socioeconomic and environmental interactions between distant places. Viewed through the lens of the telecoupling framework, land use and food consumption are linked across local to global scales by decision-making agents and trade flows. Quantitatively modelling the dynamics of telecoupled systems like this could be achieved using numerous different modelling approaches. For example, previous approaches to modelling global food trade have often used partial equilibrium economic models, whereas recent approaches to representing local land use decision-making have widely used agent-based modelling. System dynamics models are well established for representing aggregated flows and stores of products and values between distant locations. We argue that hybrid computational models will be useful for capitalising on the strengths these different modelling approaches each have for representing the various concepts in the telecoupling framework. However, integrating multiple modelling approaches into hybrid models faces challenges, including data requirements and uncertainty assessment. To help guide the development of hybrid models for investigating sustainability through the telecoupling framework here we examine important representational and modelling considerations in the context of global food trade and local land use. We report on the development of our own model that incorporates multiple modelling approaches in a modular approach to negotiate the trade-offs between ideal representation and modelling resource constraints. In this initial modelling our focus is on land use and food trade in and between USA, China and Brazil, but also accounting for the rest of the world. We discuss the challenges of integrating multiple modelling approaches to enable analysis of agents, flows, and feedbacks in the telecoupled system. Our analysis indicates differences in representation of agency

  6. Integrating Geo-information Models with Participatory Approaches

    NARCIS (Netherlands)

    Nidumolu, U.B.

    2004-01-01

    In this thesis we demonstrate some methods to integrate biophysical data with socio-economic variables with applications in agricultural land use analysis. Part of Nizamabad District of Andhra Pradesh State in India is considered for developing and testing the methods developed. First the study area

  7. Modeling causes of death: an integrated approach using CODEm

    Science.gov (United States)

    2012-01-01

    Background Data on causes of death by age and sex are a critical input into health decision-making. Priority setting in public health should be informed not only by the current magnitude of health problems but by trends in them. However, cause of death data are often not available or are subject to substantial problems of comparability. We propose five general principles for cause of death model development, validation, and reporting. Methods We detail a specific implementation of these principles that is embodied in an analytical tool - the Cause of Death Ensemble model (CODEm) - which explores a large variety of possible models to estimate trends in causes of death. Possible models are identified using a covariate selection algorithm that yields many plausible combinations of covariates, which are then run through four model classes. The model classes include mixed effects linear models and spatial-temporal Gaussian Process Regression models for cause fractions and death rates. All models for each cause of death are then assessed using out-of-sample predictive validity and combined into an ensemble with optimal out-of-sample predictive performance. Results Ensemble models for cause of death estimation outperform any single component model in tests of root mean square error, frequency of predicting correct temporal trends, and achieving 95% coverage of the prediction interval. We present detailed results for CODEm applied to maternal mortality and summary results for several other causes of death, including cardiovascular disease and several cancers. Conclusions CODEm produces better estimates of cause of death trends than previous methods and is less susceptible to bias in model specification. We demonstrate the utility of CODEm for the estimation of several major causes of death. PMID:22226226

  8. An Integrated Approach to Mathematical Modeling: A Classroom Study.

    Science.gov (United States)

    Doerr, Helen M.

    Modeling, simulation, and discrete mathematics have all been identified by professional mathematics education organizations as important areas for secondary school study. This classroom study focused on the components and tools for modeling and how students use these tools to construct their understanding of contextual problems in the content area…

  9. Understanding Gulf War Illness: An Integrative Modeling Approach

    Science.gov (United States)

    2015-10-01

    research assistant Ms. Mariam Viquar, Doctor of Osteopathic Medicine (DOM) class of 2016, to continue genomic analysis of available human data under...Translational Medicine Approach to GWI: From Cells to Therapy.”  Also to promote and forward the momentum of the field, this year we have published 2... veterinarian has decided no more animals may be exposed to DFP until many palliative care studies have been conducted to see if any care conditions

  10. Understanding Gulf War Illness: An Integrative Modeling Approach

    Science.gov (United States)

    2016-10-01

    prepared with Dr. Craddock and other members of the CSB. (Task 4; Subtask1) c) Brainstormed with the Miller and O’Callaghan teams to design animal...for 2-day brainstorming session to review current candidate drug targets and develop methodological approach to computer- based drug screening (Sep. 24...committee, Chemical Hygiene and Biosafety. Important issues are related to DFP purchase, storage, dilution, exposure (injection). (Task 2; Subtask1

  11. A novel integrated renewable energy system modelling approach, allowing fast FPGA controller prototyping

    DEFF Research Database (Denmark)

    Teodorescu, Remus; Ruiz, Alberto Parera; Cirstea, Marcian

    2008-01-01

    The paper describes a new holistic approach to the modeling of integrated renewable energy systems. The method is using the DK5 modeling/design environment from Celoxica and is based on the new Handel-C programming language. The goal of the work carried out was to achieve a combined model...... containing a Xilinx Spartan II FPGA and was successfully experimentally tested. This approach enables the design and fast hardware implementation of efficient controllers for Distributed Energy Resource (DER) hybrid systems....

  12. Modelling a radiology department service using a VDL integrated approach.

    Science.gov (United States)

    Guglielmino, Maria Gabriella; Celano, Giovanni; Costa, Antonio; Fichera, Sergio

    2009-01-01

    The healthcare industry is facing several challenges such as the reduction of costs and quality improvement of the provided services. Engineering studies could be very useful in supporting organizational and management processes. Healthcare service efficiency depends on a strong collaboration between clinical and engineering experts, especially when it comes to analyzing the system and its constraints in detail and subsequently, when it comes to deciding on the reengineering of some key activities. The purpose of this paper is to propose a case study showing how a mix of representation tools allow a manager of a radiology department to solve some human and technological resource re-organizational issues, which have to be faced due to the introduction of a new technology and a new portfolio of services. In order to simulate the activities within the radiology department and examine the relationship between human and technological resources, different visual diagrammatic language (VDL) techniques have been implemented to get knowledge about the heterogeneous factors related to the healthcare service delivery. In particular, flow charts, IDEFO diagrams and Petri nets have been integrated each other with success as a modelisation tools. The simulation study performed through the application of the aforementioned VDL techniques suggests the opportunity of re-organizing the nurse activities within the radiology department. The re-organization of a healthcare service and in particular of a radiology department by means of joint flow charts, IDEF0 diagrams and Petri nets is a poorly investigated topic in literature. This paper demonstrates how flow charts and IDEF0 can help people working within the department to understand the weak points of their organization and constitute an efficient base of knowledge for the implementation of a Petri net aimed at improving the departmental performance.

  13. An integrated approach to the modelling of hydrogen assisted failure in 316L steel

    International Nuclear Information System (INIS)

    Toribio, J.; Justo, E.R.; Caballero, L.; Valiente, A.

    1998-01-01

    An integrated approach to the modelling of hydrogen assisted failure in 316L steel is presented. The approach includes experimental, fractographic, numerical and theoretical analysis of the phenomenon. The physical adequacy of the mechanical models of hydrogen embrittlement (notch extension model and notch cracking model) is discussed by comparing the virtual damage depth (theoretical) predicted by the models with the embrittled zone (microphysical) measured in the fractographic analysis by scanning electron microscopy. In addition, a numerical modelling of hydrogen diffusion is performed, concluding that bulk diffusion is not important in hydrogen embrittlement of 316L steel, so that hydrogen transport accelerated by the microdamage itself should be taken into account. (orig.)

  14. 3D Multiscale Integrated Modeling Approach of Complex Rock Mass Structures

    Directory of Open Access Journals (Sweden)

    Mingchao Li

    2014-01-01

    Full Text Available Based on abundant geological data of different regions and different scales in hydraulic engineering, a new approach of 3D engineering-scale and statistical-scale integrated modeling was put forward, considering the complex relationships among geological structures and discontinuities and hydraulic structures. For engineering-scale geological structures, the 3D rock mass model of the study region was built by the exact match modeling method and the reliability analysis technique. For statistical-scale jointed rock mass, the random network simulation modeling method was realized, including Baecher structure plane model, Monte Carlo simulation, and dynamic check of random discontinuities, and the corresponding software program was developed. Finally, the refined model was reconstructed integrating with the engineering-scale model of rock structures, the statistical-scale model of discontinuities network, and the hydraulic structures model. It has been applied to the practical hydraulic project and offers the model basis for the analysis of hydraulic rock mass structures.

  15. Integrated approaches for implementing building information modelling (BIM) in engineering education

    OpenAIRE

    Hjelseth, Eilif

    2015-01-01

    The construction industry faces high demand for candidates with relevant Building Information Modelling (BIM) competency, yet higher education continues to struggle in providing such competencies. This conceptual paper explores the use of an integrated approach to implement BIM into the curriculum for undergraduates and graduates in engineering. The curriculum under study employed the Technological Pedagogical Content Knowledge (TPACK) pedagogical framework for integrating three BIM related s...

  16. Hierarchical Agent-Based Integrated Modelling Approach for Microgrids with Adoption of EVs and HRES

    Directory of Open Access Journals (Sweden)

    Peng Han

    2014-01-01

    Full Text Available The large adoption of electric vehicles (EVs, hybrid renewable energy systems (HRESs, and the increasing of the loads shall bring significant challenges to the microgrid. The methodology to model microgrid with high EVs and HRESs penetrations is the key to EVs adoption assessment and optimized HRESs deployment. However, considering the complex interactions of the microgrid containing massive EVs and HRESs, any previous single modelling approaches are insufficient. Therefore in this paper, the methodology named Hierarchical Agent-based Integrated Modelling Approach (HAIMA is proposed. With the effective integration of the agent-based modelling with other advanced modelling approaches, the proposed approach theoretically contributes to a new microgrid model hierarchically constituted by microgrid management layer, component layer, and event layer. Then the HAIMA further links the key parameters and interconnects them to achieve the interactions of the whole model. Furthermore, HAIMA practically contributes to a comprehensive microgrid operation system, through which the assessment of the proposed model and the impact of the EVs adoption are achieved. Simulations show that the proposed HAIMA methodology will be beneficial for the microgrid study and EV’s operation assessment and shall be further utilized for the energy management, electricity consumption prediction, the EV scheduling control, and HRES deployment optimization.

  17. Integration of Bioreactor and Membrane Separation Processes: A Model Based Approach

    DEFF Research Database (Denmark)

    Prado Rubio, Oscar Andres

    test. Satisfactory results are obtained regulating the pH and managing the input constraints. The design and operability of the integrated bioreactor and REED module are investigated using the developed models and control structure. The study involves two different case studies: continuous lactic acid......This work is motivated by the need for tighter integration of industrial processes in an attempt to improve process sustainability. To this end, this work considers a interesting case study around which different systematic approaches are used or developed to achieve the above goal. The thesis...... is concerned with the understanding of an integrated bioreactor and electrically driven membrane separation processes for lactic acid fermentation. This is achieved through a model based investigation of the individual units and the integrated system. Development of system understanding is the key to reveal...

  18. MODELING OF QUALITY MANAGEMENT SYSTEM FOR ELECTRONIC LEARNING RESOURCES: THE INTEGRATED AND DIFFERENTIATED APPROACHES

    Directory of Open Access Journals (Sweden)

    H. M. Kravtsov

    2012-03-01

    Full Text Available Abstract. Results on modeling of quality management system of electronic information resources on the basis of the analysis of its elements functioning with use of the integrated and differentiated approaches are presented. Application of such model is illustrated on an example of calculation and optimization of parameters of a quality management system at the organization of the co-ordinated work of services of monitoring, an estimation of quality and support of electronic learning resources.

  19. A Modelling Approach for Integrated Planning of Port Capacity- Trade-Offs in Rotterdam Investment Planning

    Directory of Open Access Journals (Sweden)

    Sander Dekker

    2006-03-01

    Full Text Available This paper presents a modelling approach for planning ofport capacity. The approach integrates port commercial andpublic interests. It further incorporates route competition andautonomous demand growth. It is applied to port expansion,which can be considered as a strategy for an individual port todeal with route competition. The basis for solving this planningproblem comprises an analysis of port demand and supply in apartial equilibrium model. With such an approach, the reactionof a single port on the change in a transport network comprisingalternative routes to a hinterland destination can be simulated.To establish the optimal expansion strategy, port expansion iscombined with congestion pricing. This is used for the simultaneousdetermination of 1 optimal expansion size, and 2 investmentrecovery period. The modelling approach will be appliedto Rotterdam port focusing on port expansion by means ofland reclamation. The scenmio of the entry of a new competingroute via the Italian port Gioia Tauro is used to address sometrade-offs in Rotterdam investment planning.

  20. Making eco logic and models work : An integrative approach to lake ecosystem modelling

    NARCIS (Netherlands)

    Kuiper, Jan Jurjen

    2016-01-01

    Dynamical ecosystem models are important tools that can help ecologists understand complex systems, and turn understanding into predictions of how these systems respond to external changes. This thesis revolves around PCLake, an integrated ecosystem model of shallow lakes that is used by both

  1. An integrated biomechanical modeling approach to the ergonomic evaluation of drywall installation.

    Science.gov (United States)

    Yuan, Lu; Buchholz, Bryan; Punnett, Laura; Kriebel, David

    2016-03-01

    Three different methodologies: work sampling, computer simulation and biomechanical modeling, were integrated to study the physical demands of drywall installation. PATH (Posture, Activity, Tools, and Handling), a work-sampling based method, was used to quantify the percent of time that the drywall installers were conducting different activities with different body segment (trunk, arm, and leg) postures. Utilizing Monte-Carlo simulation to convert the categorical PATH data into continuous variables as inputs for the biomechanical models, the required muscle contraction forces and joint reaction forces at the low back (L4/L5) and shoulder (glenohumeral and sternoclavicular joints) were estimated for a typical eight-hour workday. To demonstrate the robustness of this modeling approach, a sensitivity analysis was conducted to examine the impact of some quantitative assumptions that have been made to facilitate the modeling approach. The results indicated that the modeling approach seemed to be the most sensitive to both the distribution of work cycles for a typical eight-hour workday and the distribution and values of Euler angles that are used to determine the "shoulder rhythm." Other assumptions including the distribution of trunk postures did not appear to have a significant impact on the model outputs. It was concluded that the integrated approach might provide an applicable examination of physical loads during the non-routine construction work, especially for those operations/tasks that have certain patterns/sequences for the workers to follow. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  2. Integrating UML, the Q-model and a Multi-Agent Approach in Process Specifications and Behavioural Models of Organisations

    Directory of Open Access Journals (Sweden)

    Raul Savimaa

    2005-08-01

    Full Text Available Efficient estimation and representation of an organisation's behaviour requires specification of business processes and modelling of actors' behaviour. Therefore the existing classical approaches that concentrate only on planned processes are not suitable and an approach that integrates process specifications with behavioural models of actors should be used instead. The present research indicates that a suitable approach should be based on interactive computing. This paper examines the integration of UML diagrams for process specifications, the Q-model specifications for modelling timing criteria of existing and planned processes and a multi-agent approach for simulating non-deterministic behaviour of human actors in an organisation. The corresponding original methodology is introduced and some of its applications as case studies are reviewed.

  3. A component-based approach to integrated modeling in the geosciences: The design of CSDMS

    Science.gov (United States)

    Peckham, Scott D.; Hutton, Eric W. H.; Norris, Boyana

    2013-04-01

    Development of scientific modeling software increasingly requires the coupling of multiple, independently developed models. Component-based software engineering enables the integration of plug-and-play components, but significant additional challenges must be addressed in any specific domain in order to produce a usable development and simulation environment that also encourages contributions and adoption by entire communities. In this paper we describe the challenges in creating a coupling environment for Earth-surface process modeling and the innovative approach that we have developed to address them within the Community Surface Dynamics Modeling System.

  4. Toward integration of genomic selection with crop modelling: the development of an integrated approach to predicting rice heading dates.

    Science.gov (United States)

    Onogi, Akio; Watanabe, Maya; Mochizuki, Toshihiro; Hayashi, Takeshi; Nakagawa, Hiroshi; Hasegawa, Toshihiro; Iwata, Hiroyoshi

    2016-04-01

    It is suggested that accuracy in predicting plant phenotypes can be improved by integrating genomic prediction with crop modelling in a single hierarchical model. Accurate prediction of phenotypes is important for plant breeding and management. Although genomic prediction/selection aims to predict phenotypes on the basis of whole-genome marker information, it is often difficult to predict phenotypes of complex traits in diverse environments, because plant phenotypes are often influenced by genotype-environment interaction. A possible remedy is to integrate genomic prediction with crop/ecophysiological modelling, which enables us to predict plant phenotypes using environmental and management information. To this end, in the present study, we developed a novel method for integrating genomic prediction with phenological modelling of Asian rice (Oryza sativa, L.), allowing the heading date of untested genotypes in untested environments to be predicted. The method simultaneously infers the phenological model parameters and whole-genome marker effects on the parameters in a Bayesian framework. By cultivating backcross inbred lines of Koshihikari × Kasalath in nine environments, we evaluated the potential of the proposed method in comparison with conventional genomic prediction, phenological modelling, and two-step methods that applied genomic prediction to phenological model parameters inferred from Nelder-Mead or Markov chain Monte Carlo algorithms. In predicting heading dates of untested lines in untested environments, the proposed and two-step methods tended to provide more accurate predictions than the conventional genomic prediction methods, particularly in environments where phenotypes from environments similar to the target environment were unavailable for training genomic prediction. The proposed method showed greater accuracy in prediction than the two-step methods in all cross-validation schemes tested, suggesting the potential of the integrated approach in

  5. An Integrated Modeling Approach Combining Multifractal Urban Planning with a Space Syntax Perspective

    Directory of Open Access Journals (Sweden)

    Claudia Yamu

    2017-12-01

    Full Text Available The United Nations Paris agreement of 2015 highlighted the need for urban planning to prevent and contain urban sprawl so as to reduce trip lengths through an efficient distribution of agglomerations and a well-balanced urban pattern distribution, all while considering travel behavior and accessibility to green areas, services, and facilities on different temporal scales. For the Vienna-Bratislava metropolitan region, our integrated modeling approach uses a combination of multifractal spatial modeling along with a space syntax perspective. Multifractal strategies are intrinsically multiscalar and adhere to five planning principles: hierarchical (polycentric urban development to manage urban sprawl; sustainable transit-oriented development; locally well-balanced urban pattern and functions distribution to enhance vital urban systems, local centers, and neighborhoods; penetration of green areas into built-up areas; and the preservation of large interconnected networks of green areas to conserve biodiversity. Adding space syntax modeling to a multifractal strategy integrates how space relates to functional patterns based on centrality, thus applying a socio-spatial perspective. In this paper, we used the following workflow for an integrated modeling approach: (1 Space syntax to identify the urban systems’ hierarchy and so determine a spatial strategy regionally; (2 Fractalopolis to create a multifractal development plan for potential urbanization; and (3 Space syntax to design a strategic urban master plan for locating new housing and facilities vis-à-vis socioeconomic factors.

  6. Integrated Approach Model of Risk, Control and Auditing of Accounting Information Systems

    Directory of Open Access Journals (Sweden)

    Claudiu BRANDAS

    2013-01-01

    Full Text Available The use of IT in the financial and accounting processes is growing fast and this leads to an increase in the research and professional concerns about the risks, control and audit of Ac-counting Information Systems (AIS. In this context, the risk and control of AIS approach is a central component of processes for IT audit, financial audit and IT Governance. Recent studies in the literature on the concepts of risk, control and auditing of AIS outline two approaches: (1 a professional approach in which we can fit ISA, COBIT, IT Risk, COSO and SOX, and (2 a research oriented approach in which we emphasize research on continuous auditing and fraud using information technology. Starting from the limits of existing approaches, our study is aimed to developing and testing an Integrated Approach Model of Risk, Control and Auditing of AIS on three cycles of business processes: purchases cycle, sales cycle and cash cycle in order to improve the efficiency of IT Governance, as well as ensuring integrity, reality, accuracy and availability of financial statements.

  7. Consequence Based Design. An approach for integrating computational collaborative models (Integrated Dynamic Models) in the building design phase

    DEFF Research Database (Denmark)

    Negendahl, Kristoffer

    to visualize any relevant building performance. AHP – the use of Analytic Hierarchy Process to clarify differences between solutions on both qualitative and quantitative evaluations. Termite – the implementation of the BPS tool solver Be10 as a plugin for Grasshopper that enables live feedback of entire...... building energy consumption. HQSS – a quasi-steady-state BPS tool solver dedicated for fast thermal analyses in Grasshopper. Moth – an agent-based optimization algorithm implemented in Grasshopper that attempts to combine qualitative and quantitative evaluations during optimization. Sentient models...... – a method to listen to user behaviour in Grasshopper and decrease the space of solutions. Surrogate models – a test of machine learning methods to speed up any BPS feedback through surrogate models with Grasshopper. This thesis demonstrates how integrated dynamic models may include building performance...

  8. THE MODEL OF REALIZATION OF INTEGRATIVE APPROACH TO THE WORK WITH PEDAGOGICALLY GIFTED STUDENTS

    Directory of Open Access Journals (Sweden)

    Golubova Anna Vasilievna

    2013-05-01

    Full Text Available The article examines the components and criteria of pedagogical giftedness of students; the levels of formedness and pedagogical conditions of its development are identified. Purpose: to describe the model of realization of integrative approach to the work with pedagogically gifted students in educational space of university. Methodology: theoretical level methods of pedagogical phenomena learning, methods of empirical level (observation, interviewing, questionnaires, conversations, psychological tests etc.. The results of the research proved that phased realization of integrative approach to the work with pedagogically gifted students in educational space of university provides the rising of pedagogically giftedness formation level. The next pedagogical conditions of pedagogically giftedness formation are described: the creation of pedagogically-oriented creative environment; promotion of positive motivational setting for future professional and educational activities; attracting future teachers to the creative professional-oriented learning and cognitive activity. Practical implications: the educational process of higher pedagogical educational institutions.

  9. Modeling and analysis of a decentralized electricity market: An integrated simulation/optimization approach

    International Nuclear Information System (INIS)

    Sarıca, Kemal; Kumbaroğlu, Gürkan; Or, Ilhan

    2012-01-01

    In this study, a model is developed to investigate the implications of an hourly day-ahead competitive power market on generator profits, electricity prices, availability and supply security. An integrated simulation/optimization approach is employed integrating a multi-agent simulation model with two alternative optimization models. The simulation model represents interactions between power generator, system operator, power user and power transmitter agents while the network flow optimization model oversees and optimizes the electricity flows, dispatches generators based on two alternative approaches used in the modeling of the underlying transmission network: a linear minimum cost network flow model and a non-linear alternating current optimal power flow model. Supply, demand, transmission, capacity and other technological constraints are thereby enforced. The transmission network, on which the scenario analyses are carried out, includes 30 bus, 41 lines, 9 generators, and 21 power users. The scenarios examined in the analysis cover various settings of transmission line capacities/fees, and hourly learning algorithms. Results provide insight into key behavioral and structural aspects of a decentralized electricity market under network constraints and reveal the importance of using an AC network instead of a simplified linear network flow approach. -- Highlights: ► An agent-based simulation model with an AC transmission environment with a day-ahead market. ► Physical network parameters have dramatic effects over price levels and stability. ► Due to AC nature of transmission network, adaptive agents have more local market power than minimal cost network flow. ► Behavior of the generators has significant effect over market price formation, as pointed out by bidding strategies. ► Transmission line capacity and fee policies are found to be very effective in price formation in the market.

  10. Modeling an integrated hospital management planning problem using integer optimization approach

    Science.gov (United States)

    Sitepu, Suryati; Mawengkang, Herman; Irvan

    2017-09-01

    Hospital is a very important institution to provide health care for people. It is not surprising that nowadays the people’s demands for hospital is increasing. However, due to the rising cost of healthcare services, hospitals need to consider efficiencies in order to overcome these two problems. This paper deals with an integrated strategy of staff capacity management and bed allocation planning to tackle these problems. Mathematically, the strategy can be modeled as an integer linear programming problem. We solve the model using a direct neighborhood search approach, based on the notion of superbasic variables.

  11. The elastic body model: a pedagogical approach integrating real time measurements and modelling activities

    International Nuclear Information System (INIS)

    Fazio, C; Guastella, I; Tarantino, G

    2007-01-01

    In this paper, we describe a pedagogical approach to elastic body movement based on measurements of the contact times between a metallic rod and small bodies colliding with it and on modelling of the experimental results by using a microcomputer-based laboratory and simulation tools. The experiments and modelling activities have been built in the context of the laboratory of mechanical wave propagation of the two-year graduate teacher education programme of Palermo's University. Some considerations about observed modifications in trainee teachers' attitudes in utilizing experiments and modelling are discussed

  12. Integrative modelling approaches for analysis of impact of multifunctional agriculture: a review for France, Germany and The Netherlands

    NARCIS (Netherlands)

    Rossing, W.A.H.; Zander, P.; Josien, E.; Groot, J.C.J.; Meyer, B.C.; Knierim, A.

    2007-01-01

    This paper reviews integrative modelling approaches which were developed to analyze the impact of multifunctional agriculture, or which may be used as such. The approaches are integrative in combining multiple goals of agriculture, and confronting these with current or potential performance of

  13. Modeling of integral-type Stirling refrigerator using system dynamics approach

    Energy Technology Data Exchange (ETDEWEB)

    Huang, B.J.; Chen, H.Y. [National Taiwan Univ., Dept. of Mechanical Engineering, Taipei (Taiwan)

    2000-07-01

    A modeling of the integral-type Stirling refrigerator (ITSR) using a system dynamics approach is developed in the present study. The system dynamics models are derived to describe the input/output relation of each component of an ITSR. Connecting the equivalent circuits of the components together, we obtain a flow network diagram and derive a transfer function to represent system dynamics behavior of an ITSR. The performance analysis of an ITSR is then easily carried out by use of the transfer function with sinusoidal signal assumption. The performance calculation for a test refrigerator has shown that the analysis is accurate. An empirical correlation for a correction coefficient r in the expansion space was also derived for better results. The present study has demonstrated how a linear system theory or system dynamics approach can be applied to the design of an ITSR. (Author)

  14. Automated model integration at source code level: An approach for implementing models into the NASA Land Information System

    Science.gov (United States)

    Wang, S.; Peters-Lidard, C. D.; Mocko, D. M.; Kumar, S.; Nearing, G. S.; Arsenault, K. R.; Geiger, J. V.

    2014-12-01

    Model integration bridges the data flow between modeling frameworks and models. However, models usually do not fit directly into a particular modeling environment, if not designed for it. An example includes implementing different types of models into the NASA Land Information System (LIS), a software framework for land-surface modeling and data assimilation. Model implementation requires scientific knowledge and software expertise and may take a developer months to learn LIS and model software structure. Debugging and testing of the model implementation is also time-consuming due to not fully understanding LIS or the model. This time spent is costly for research and operational projects. To address this issue, an approach has been developed to automate model integration into LIS. With this in mind, a general model interface was designed to retrieve forcing inputs, parameters, and state variables needed by the model and to provide as state variables and outputs to LIS. Every model can be wrapped to comply with the interface, usually with a FORTRAN 90 subroutine. Development efforts need only knowledge of the model and basic programming skills. With such wrappers, the logic is the same for implementing all models. Code templates defined for this general model interface could be re-used with any specific model. Therefore, the model implementation can be done automatically. An automated model implementation toolkit was developed with Microsoft Excel and its built-in VBA language. It allows model specifications in three worksheets and contains FORTRAN 90 code templates in VBA programs. According to the model specification, the toolkit generates data structures and procedures within FORTRAN modules and subroutines, which transfer data between LIS and the model wrapper. Model implementation is standardized, and about 80 - 90% of the development load is reduced. In this presentation, the automated model implementation approach is described along with LIS programming

  15. A Hydro-Economic Approach to Representing Water Resources Impacts in Integrated Assessment Models

    Energy Technology Data Exchange (ETDEWEB)

    Kirshen, Paul H.; Strzepek, Kenneth, M.

    2004-01-14

    Grant Number DE-FG02-98ER62665 Office of Energy Research of the U.S. Department of Energy Abstract Many Integrated Assessment Models (IAM) divide the world into a small number of highly aggregated regions. Non-OECD countries are aggregated geographically into continental and multiple-continental regions or economically by development level. Current research suggests that these large scale aggregations cannot accurately represent potential water resources-related climate change impacts. In addition, IAMs do not explicitly model the flow regulation impacts of reservoir and ground water systems, the economics of water supply, or the demand for water in economic activities. Using the International Model for Policy Analysis of Agricultural Commodities and Trade (IMPACT) model of the International Food Policy Research Institute (IFPRI) as a case study, this research implemented a set of methodologies to provide accurate representation of water resource climate change impacts in Integrated Assessment Models. There were also detailed examinations of key issues related to aggregated modeling including: modeling water consumption versus water withdrawals; ground and surface water interactions; development of reservoir cost curves; modeling of surface areas of aggregated reservoirs for estimating evaporation losses; and evaluating the importance of spatial scale in river basin modeling. The major findings include: - Continental or national or even large scale river basin aggregation of water supplies and demands do not accurately capture the impacts of climate change in the water and agricultural sector in IAMs. - Fortunately, there now exist gridden approaches (0.5 X 0.5 degrees) to model streamflows in a global analysis. The gridded approach to hydrologic modeling allows flexibility in aligning basin boundaries with national boundaries. This combined with GIS tools, high speed computers, and the growing availability of socio-economic gridded data bases allows assignment of

  16. Integrated approach to model decomposed flow hydrograph using artificial neural network and conceptual techniques

    Science.gov (United States)

    Jain, Ashu; Srinivasulu, Sanaga

    2006-02-01

    This paper presents the findings of a study aimed at decomposing a flow hydrograph into different segments based on physical concepts in a catchment, and modelling different segments using different technique viz. conceptual and artificial neural networks (ANNs). An integrated modelling framework is proposed capable of modelling infiltration, base flow, evapotranspiration, soil moisture accounting, and certain segments of the decomposed flow hydrograph using conceptual techniques and the complex, non-linear, and dynamic rainfall-runoff process using ANN technique. Specifically, five different multi-layer perceptron (MLP) and two self-organizing map (SOM) models have been developed. The rainfall and streamflow data derived from the Kentucky River catchment were employed to test the proposed methodology and develop all the models. The performance of all the models was evaluated using seven different standard statistical measures. The results obtained in this study indicate that (a) the rainfall-runoff relationship in a large catchment consists of at least three or four different mappings corresponding to different dynamics of the underlying physical processes, (b) an integrated approach that models the different segments of the decomposed flow hydrograph using different techniques is better than a single ANN in modelling the complex, dynamic, non-linear, and fragmented rainfall runoff process, (c) a simple model based on the concept of flow recession is better than an ANN to model the falling limb of a flow hydrograph, and (d) decomposing a flow hydrograph into the different segments corresponding to the different dynamics based on the physical concepts is better than using the soft decomposition employed using SOM.

  17. Biophysical Interactions in Porous Media: an Integrated Experimental and Modelling Approach

    Science.gov (United States)

    Otten, W.; Baveye, P.; Falconer, R.

    2012-12-01

    A critical feature of porous media is that the geometry provides habitats of a complexity that is not seen above ground, offering shelter, food water and gasses to microorganisms, who's spatial and temporal dynamics are shaped by this microscopic heterogeneity. The microbial dynamics, including fungal and bacterial growth, in turn affect the geometry and the hydrological properties, shaping the pore architecture at short and long time scales, altering surface tension, and (partially) blocking pores, thereby affecting the flow paths of water through a structure. Crucially, the majority of these processes occur at microscopic scales with impact on larger scale ecological processes and ecosystem services. The complexity of these interacting processes and feed-back mechanisms at first may seem overwhelming. However, we show in this paper how with recent progress in experimental techniques, integrated with a modelling approach we can begin to understand the importance of microscopic heterogeneity on microbial dynamics. We will demonstrate this integrated approach for fungal dynamics in porous media such as soil through a combination of novel experimental tools and mathematical modelling. Using benchtop X-ray CT systems we present the finer detail of pore structure at scales relevant for microbial processes, and present our recent advances in the use of theoretical tools to rigorously characterise, and quantitatively describe this environment, and present the state-of-the art with respect to visualization of water in porous media. Severe challenges remain with studying the spatial distribution of microorganisms. We present how biological thin sectioning techniques offer a way forward to study the spatial distribution of fungi and bacteria within pore geometries. Through a series of detailed experiments we show how pathways, resulting from connected pore volumes and distribution of water within them, are preferentially explored during fungal invasion. We complement the

  18. Integrating operational watershed and coastal models for the Iberian Coast: Watershed model implementation - A first approach

    Science.gov (United States)

    Brito, David; Campuzano, F. J.; Sobrinho, J.; Fernandes, R.; Neves, R.

    2015-12-01

    River discharges and loads are essential inputs to coastal seas, and thus for coastal seas modelling, and their properties are the result of all activities and policies carried inland. For these reasons main rivers were object of intense monitoring programs having been generated some important amount of historical data. Due to the decline in the Portuguese hydrometric network and in order to quantify and forecast surface water streamflow and nutrients to coastal areas, the MOHID Land model was applied to the Western Iberia Region with a 2 km horizontal resolution and to the Iberian Peninsula with 10 km horizontal resolution. The domains were populated with land use and soil properties and forced with existing meteorological models. This approach also permits to understand how the flows and loads are generated and to forecast their values which are of utmost importance to perform coastal ocean and estuarine forecasts. The final purpose of the implementation is to obtain fresh water quantity and quality that could be used to support management decisions in the watershed, reservoirs and also to estuaries and coastal areas. A process oriented model as MOHID Land is essential to perform this type of simulations, as the model is independent of the number of river catchments. In this work, the Mohid Land model equations and parameterisations were described and an innovative methodology for watershed modelling is presented and validated for a large international river, the Tagus River, and the largest national river of Portugal, the Mondego River. Precipitation, streamflow and nutrients modelling results for these two rivers were compared with observations near their coastal outlet in order to evaluate the model capacity to represent the main watershed trends. Finally, an annual budget of fresh water and nutrient transported by the main twenty five rivers discharging in the Portuguese coast is presented.

  19. Integrating Magnetic and Modelling Approaches to Reconstruct Ocean Circulation at the LGM

    Science.gov (United States)

    Watkins, S.; Maher, B.; Bigg, G.

    2008-12-01

    Formation of N. Atlantic Deep Water (NADW) is an important component of the ocean thermohaline circulation but debate exists over the ocean circulation state during glacial stages. Some geological and modelling studies suggest decreased NADW and increased formation of Southern Ocean deep water during the Last Glacial Maximum (LGM); others indicate similar, or higher, rates of NADW advection. Here, we use an innovative, integrated approach combining ocean and general circulation model results with ground- truthing measurements of sediment magnetic properties, in order to test two different potential LGM ocean states. We compare modelled iceberg trajectories produced by each of the stable modeled ocean states with magnetically-mapped patterns and sources of LGM ice-rafted debris (IRD). One LGM state is characterised by vigorous NADW formation; the other by dominant deep water production in the Southern Ocean. Cluster analysis of sediment magnetic properties was used to characterise N. Atlantic IRD patterns and sources, which match most closely iceberg trajectories arising from some combination of the 'southern-sinking' and 'intermediate' ocean circulation states. The magnetic data indicate two major IRD sources, Fennoscandia and Greenland/Iceland, and one minor source, the St Lawrence region. The model and magnetic data suggest that the LGM N. Atlantic circulation was dominated by a cyclonic central N. Atlantic gyre, separated from the N. Atlantic Current which was displaced south of ~ 42 oN. This approach can provide discriminatory evidence and validation of past ocean circulation states, on an ocean-wide and non-sample destructive basis.

  20. Fine Surveying and 3D Modeling Approach for Wooden Ancient Architecture via Multiple Laser Scanner Integration

    Directory of Open Access Journals (Sweden)

    Qingwu Hu

    2016-03-01

    Full Text Available A multiple terrestrial laser scanner (TLS integration approach is proposed for the fine surveying and 3D modeling of ancient wooden architecture in an ancient building complex of Wudang Mountains, which is located in very steep surroundings making it difficult to access. Three-level TLS with a scalable measurement distance and accuracy is presented for data collection to compensate for data missed because of mutual sheltering and scanning view limitations. A multi-scale data fusion approach is proposed for data registration and filtering of the different scales and separated 3D data. A point projection algorithm together with point cloud slice tools is designed for fine surveying to generate all types of architecture maps, such as plan drawings, facade drawings, section drawings, and doors and windows drawings. The section drawings together with slicing point cloud are presented for the deformation analysis of the building structure. Along with fine drawings and laser scanning data, the 3D models of the ancient architecture components are built for digital management and visualization. Results show that the proposed approach can achieve fine surveying and 3D documentation of the ancient architecture within 3 mm accuracy. In addition, the defects of scanning view and mutual sheltering can overcome to obtain the complete and exact structure in detail.

  1. The Anthropology of Science Education Reform: An Alabama Model for Building an Integrated Stakeholder Systems Approach

    Science.gov (United States)

    Denson, R. L.; Cox, G. N.

    2004-12-01

    Anthropologists are concerned with every aspect of the culture they are investigating. One of the five main branches of anthropology, socio-cultural anthropology, concerns itself with studying the relationship between behavior and culture. This paper explores the concept that changing the behavior of our culture - its beliefs and values - towards science is at the heart of science education reform. There are five institutions that socio-cultural anthropologists use to study the social organization of cultures: the educational system is only one of them. Its function - across all cultures - is to serve as a mechanism for implementing change in cultural beliefs and values. As leaders of science education reform, the Alabama model contends that we must stop the struggle with our purpose and get on with the business of leading culture change through an integrated stakeholder systems approach. This model stresses the need for the interaction of agencies other than education - including government, industry, the media and our health communities to operate in an integrated and systemic fashion to address the issues of living among a technically literate society. Twenty-five years of science education reform needs being voiced and programs being developed has not produced the desired results from within the educational system. This is too limited a focus to affect any real cultural change. It is when we acknowledge that students spend only an average of 12 percent of their life time in schools, that we can begin to ask ourselves what are our students learning the other 88 percent of their time - from their peers, their parents and the media - and what should we be doing to address this cultural crisis in these other arenas in addition to the educational system? The Alabama Math, Science and Technology Education Coalition (AMSTEC) is a non-profit 501c(3) organization operating in the state of Alabama to provide leadership in improving mathematics, science, and technology

  2. Spatial Analytic Hierarchy Process Model for Flood Forecasting: An Integrated Approach

    International Nuclear Information System (INIS)

    Matori, Abd Nasir; Yusof, Khamaruzaman Wan; Hashim, Mustafa Ahmad; Lawal, Dano Umar; Balogun, Abdul-Lateef

    2014-01-01

    Various flood influencing factors such as rainfall, geology, slope gradient, land use, soil type, drainage density, temperature etc. are generally considered for flood hazard assessment. However, lack of appropriate handling/integration of data from different sources is a challenge that can make any spatial forecasting difficult and inaccurate. Availability of accurate flood maps and thorough understanding of the subsurface conditions can adequately enhance flood disasters management. This study presents an approach that attempts to provide a solution to this drawback by combining Geographic Information System (GIS)-based Analytic Hierarchy Process (AHP) model as spatial forecasting tools. In achieving the set objectives, spatial forecasting of flood susceptible zones in the study area was made. A total number of five set of criteria/factors believed to be influencing flood generation in the study area were selected. Priority weights were assigned to each criterion/factor based on Saaty's nine point scale of preference and weights were further normalized through the AHP. The model was integrated into a GIS system in order to produce a flood forecasting map

  3. An analytical approach to model manufacturing a drift heterobipolar transistors: On approach to optimize technological process to increase integration rate

    Science.gov (United States)

    Pankratov, E. L.; Bulaeva, E. A.

    2015-03-01

    In this paper, we introduce an approach to increase integration rate of drift heterobipolar transistors. The approach is based on manufacturing of heterostructure with spatial configuration, doping of required areas of the heterostructure by diffusion or ion implantation and optimization of annealing of dopant and/or radiation defects.

  4. A Temporal-Causal Modelling Approach to Integrated Contagion and Network Change in Social Networks

    NARCIS (Netherlands)

    Blankendaal, Romy; Parinussa, Sarah; Treur, Jan

    2016-01-01

    This paper introduces an integrated temporal-causal model for dynamics in social networks addressing the contagion principle by which states are affected mutually, and both the homophily principle and the more-becomes-more principle by which connections are adapted over time. The integrated model

  5. Integrated Management Systems::a model based on a total quality approach

    OpenAIRE

    Dale, B G.

    2001-01-01

    Describes a model based on empirical research which provides the details of an integrated management system and takes into account existing and accepted definitions of quality management, environmental management, and occupational health and safety management systems. Claims that the model addresses the issues of scope and culture which none of the existing integrated management system models address. The model has been tested with a sample of members of the British Standards Society. Among t...

  6. An Integrated Modeling Approach to Evaluate and Optimize Data Center Sustainability, Dependability and Cost

    Directory of Open Access Journals (Sweden)

    Gustavo Callou

    2014-01-01

    Full Text Available Data centers have evolved dramatically in recent years, due to the advent of social networking services, e-commerce and cloud computing. The conflicting requirements are the high availability levels demanded against the low sustainability impact and cost values. The approaches that evaluate and optimize these requirements are essential to support designers of data center architectures. Our work aims to propose an integrated approach to estimate and optimize these issues with the support of the developed environment, Mercury. Mercury is a tool for dependability, performance and energy flow evaluation. The tool supports reliability block diagrams (RBD, stochastic Petri nets (SPNs, continuous-time Markov chains (CTMC and energy flow (EFM models. The EFM verifies the energy flow on data center architectures, taking into account the energy efficiency and power capacity that each device can provide (assuming power systems or extract (considering cooling components. The EFM also estimates the sustainability impact and cost issues of data center architectures. Additionally, a methodology is also considered to support the modeling, evaluation and optimization processes. Two case studies are presented to illustrate the adopted methodology on data center power systems.

  7. Integrated decision making model for urban disaster management: A multi-objective genetic algorithm approach

    Directory of Open Access Journals (Sweden)

    V. Esmaeili

    2014-01-01

    Full Text Available In recent decays, there has been an extensive improvement in technology and knowledge; hence, human societies have started to fortify their urban environment against the natural disasters in order to diminish the context of vulnerability. Local administrators as well as government officials are thinking about new options for disaster management programs within their territories. Planning to set up local disaster management facilities and stock pre-positioning of relief items can keep an urban area prepared for a natural disaster. In this paper, based on a real-world case study for a municipal district in Tehran, a multi-objective mathematical model is developed for the location-distribution problem. The proposed model considers the role of demand in an urban area, which might be affected by neighbor wards. Integrating decision-making process for a disaster helps to improve a better relief operation during response phase of disaster management cycle. In the proposed approach, a proactive damage estimation method is used to estimate demands for the district based on worst-case scenario of earthquake in Tehran. Since such model is designed for an entire urban district, it is considered to be a large-scale mixed integer problem and hence, a genetic algorithm is developed to solve the model.

  8. Integration a functional approach

    CERN Document Server

    Bichteler, Klaus

    1998-01-01

    This book covers Lebesgue integration and its generalizations from Daniell's point of view, modified by the use of seminorms. Integrating functions rather than measuring sets is posited as the main purpose of measure theory. From this point of view Lebesgue's integral can be had as a rather straightforward, even simplistic, extension of Riemann's integral; and its aims, definitions, and procedures can be motivated at an elementary level. The notion of measurability, for example, is suggested by Littlewood's observations rather than being conveyed authoritatively through definitions of (sigma)-algebras and good-cut-conditions, the latter of which are hard to justify and thus appear mysterious, even nettlesome, to the beginner. The approach taken provides the additional benefit of cutting the labor in half. The use of seminorms, ubiquitous in modern analysis, speeds things up even further. The book is intended for the reader who has some experience with proofs, a beginning graduate student for example. It might...

  9. Integrated modeling and experimental approach for determining transcription factor profiles from fluorescent reporter data

    Directory of Open Access Journals (Sweden)

    Jayaraman Arul

    2008-07-01

    Full Text Available Abstract Background The development of quantitative models of signal transduction, as well as parameter estimation to improve existing models, depends on the ability to obtain quantitative information about various proteins that are part of the signaling pathway. However, commonly-used measurement techniques such as Western blots and mobility shift assays provide only qualitative or semi-quantitative data which cannot be used for estimating parameters. Thus there is a clear need for techniques that enable quantitative determination of signal transduction intermediates. Results This paper presents an integrated modeling and experimental approach for quantitatively determining transcription factor profiles from green fluorescent protein (GFP reporter data. The technique consists of three steps: (1 creating data sets for green fluorescent reporter systems upon stimulation, (2 analyzing the fluorescence images to determine fluorescence intensity profiles using principal component analysis (PCA and K-means clustering, and (3 computing the transcription factor concentration from the fluorescence intensity profiles by inverting a model describing transcription, translation, and activation of green fluorescent proteins. We have used this technique to quantitatively characterize activation of the transcription factor NF-κB by the cytokine TNF-α. In addition, we have applied the quantitative NF-κB profiles obtained from our technique to develop a model for TNF-α signal transduction where the parameters were estimated from the obtained data. Conclusion The technique presented here for computing transcription factor profiles from fluorescence microscopy images of reporter cells generated quantitative data on the magnitude and dynamics of NF-κB activation by TNF-α. The obtained results are in good agreement with qualitative descriptions of NF-κB activation as well as semi-quantitative experimental data from the literature. The profiles computed from

  10. Dynamics of riparian plant communities, a new integrative ecohydrological modelling approach

    Science.gov (United States)

    García-Arias, Alicia; Francés, Félix

    2015-04-01

    The Riparian Vegetation Dynamic Model (RVDM) integrates the impacts of the hydrological extremes on the vegetation, the vegetation evolution and the competition between different vegetation classes. Considering a daily time step and a detailed spatial resolution, RVDM allows the analysis of the dynamic vegetation distribution in riverine areas during a simulated period. The riparian vegetation wellbeing and distribution are considered to be conditioned by the river hydrodynamics in RVDM. Using biomass loss functions, the stress caused by hydrological extreme events is translated into changes on the distribution of the vegetation. These extreme events are considered as removal and asphyxia associated to floods, and wilt related to droughts. The variables considered to determine the impacts are water shear stress, water table elevation and the soil moisture, respectively. RVDM includes the modelling of the natural evolution of the vegetation. The potential recruitment in bared areas, the plant growth and the succession/retrogression between plant categories are included in the model conceptualization. The recruitment takes place when seeds presence, germination and seedlings establishment overcome, so it depends on the plant reproductive period and the environmental conditions. Light use efficiency determines the vegetation growth in terms of biomass production while the soil moisture limits this biomass production and the successional evolution. Finally, the competition modelling considers the advantages between successional patterns under the specific soil moisture conditions of each unit area. Several meteorological, morphological, hydrological and hydraulic inputs are required. In addition, an initial vegetation condition is required for RVDM to start the simulation period. The model results on new vegetation maps that are considered as new inputs in the next model step. Following this approach the model simulates iteratively al the processes day by day. This

  11. A new approach to testing an integrated water systems model using qualitative scenarios

    NARCIS (Netherlands)

    Giang, N.T.; de Kok, Jean-Luc; Titus, M.J.

    2007-01-01

    Integrated systems models have been developed over decades, aiming to support the decision-makers in the planning and managing of natural resources. The inherent model complexity, lack of knowledge about the linkages among model components, scarcity of field data, and uncertainty involved with

  12. An integrated ethical approach to bioethical decision-making: A proposed model for ministers

    Directory of Open Access Journals (Sweden)

    Magdalena C. de Lange

    2012-10-01

    Full Text Available This article outlined a model for guidance in ‘doing’ bioethics in a Reformed context. The proposed model suggested that in order to arrive at responsible ethical decisions, one must refer to both contextual elements and theory. The theoretical grounding for this model was based on the integration of a deontological and virtue ethics approach, arguing that virtue enables persons to know and desire the right moral ends and motivates them to carry out appropriate action toward achieving these ends. An integrative model opens up the possibility whereby bioethics as a systematic tool provides the individual decision-maker with the critical-reflective skills and justification for the ultimate choice that is lacking in the general decision-making processes. This could lead to clearer thinking and increased confidence in the justification of decisions within the Reformed tradition. The proposed hermeneutical perspective on ethical decision-making represents a shift in views about the nature of knowledge and the process of how we come to know. The key to this hermeneutical approach is to acknowledge the dialectic between the universal and the subjectivity of human relations. Working in specific religious communities, one needs to take cognisance of the fact that knowledge is situated in the context of human relationships in which the interpreter participates when articulating the meaning of bioethical experiences. Another aspect that is anticipated lies in the realisation that people struggling with bioethical dilemmas should not be viewed as isolated individuals, but as members of a broader faith community. ‘n Geïntegreerde etiese benadering tot bioetiese besluitneming: Voorgestelde model vir predikante. Hierdie artikel het ‘n model geskets wat moontlike riglyne aantoon vir die  beoefening  van  bioetiek  binne  ‘n  Gereformeerde  konteks.  Die  voorgestelde  model argumenteer dat verwysing na beide kontekstuele elemente en teorie

  13. A Model-Based Approach to Attention and Sensory Integration in Postural Control of Older Adults

    OpenAIRE

    Mahboobin, Arash; Loughlin, Patrick J.; Redfern, Mark S.

    2007-01-01

    We conducted a dual-task experiment that involved information processing (IP) tasks concurrent with postural perturbations to explore the interaction between attention and sensory integration in postural control in young and older adults. A postural control model incorporating sensory integration and the influence of attention was fit to the data, from which parameters were then obtained to quantify the interference of attention on postural control. The model hypothesizes that the cognitive p...

  14. APPROACHES TO PUBLIC INTEGRITY

    Directory of Open Access Journals (Sweden)

    Simona-Roxana ULMAN

    2015-08-01

    Full Text Available Both concepts, integrity and public integrity, are always asked qualities in the social and economic environment, but they are never well defined. In this context, finding precise definitions and offering an ample explanation of the concepts are desired and useful for both economic theoretical and practical levels and become the aim of the present paper. Without a good understanding of a concept, no one is capable to attain it. In this context, it is impossible to ask for a public sector of integrity if both public actors and the citizens do not know what it really means. Therefore, the public actors first have to understand what integrity really supposes, and, then, to be capable to respect its principles. Taking into consideration the effects of public integrity or, on its opposite, of the divergence from it, especially represented by the phenomenon of corruption, on the economy at the macro, but also, on the micro level, public integrity in itself becomes a real economic problem that is aimed to be extensively analyzed through our interdisciplinary approach.

  15. The 5C model: A new approach to asset integrity management

    International Nuclear Information System (INIS)

    Rahim, Yousif; Refsdal, Ingbjorn; Kenett, Ron S.

    2010-01-01

    As organizations grow more complex in operation and more global in scope, assets and technical integrity become key success factors. A company's asset integrity business process needs to be mapped in order to 1) provide a proper overview of operation and business processes, 2) identify all critical interfaces and 3) ensure that all gaps and overlaps in processes are eliminated. Achieving asset integrity requires companies to sustain their activities and identify the hazards, weaknesses and objectives of their strategic assets. Technical integrity emphasizes a complete overview of technical conditions and related information, and the ability of the companies to document the technical state of its assets. It is based on an integrated view of the current state of operations, and the identification of all critical interfaces, in order to ensure that all gaps and unnecessary overlaps in processes are eliminated. Companies look increasingly at their asset integrity management system as a means to extend the life of their assets, beyond the original design conditions and production capacity. Establishing an asset integrity management system requires the documentation of the company's technical integrity management, a strategy and the processes for carrying it out, identifying gaps; selecting corrective interventions and conducting follow up actions. The paper discusses various aspects of asset integrity management, including its planning and implementation. We begin with an introduction to asset technical integrity, provide some theoretical backgrounds, present a model we call 5C and conclude with a summary and discussion.

  16. A refined regional modeling approach for the Corn Belt - Experiences and recommendations for large-scale integrated modeling

    Science.gov (United States)

    Panagopoulos, Yiannis; Gassman, Philip W.; Jha, Manoj K.; Kling, Catherine L.; Campbell, Todd; Srinivasan, Raghavan; White, Michael; Arnold, Jeffrey G.

    2015-05-01

    Nonpoint source pollution from agriculture is the main source of nitrogen and phosphorus in the stream systems of the Corn Belt region in the Midwestern US. This region is comprised of two large river basins, the intensely row-cropped Upper Mississippi River Basin (UMRB) and Ohio-Tennessee River Basin (OTRB), which are considered the key contributing areas for the Northern Gulf of Mexico hypoxic zone according to the US Environmental Protection Agency. Thus, in this area it is of utmost importance to ensure that intensive agriculture for food, feed and biofuel production can coexist with a healthy water environment. To address these objectives within a river basin management context, an integrated modeling system has been constructed with the hydrologic Soil and Water Assessment Tool (SWAT) model, capable of estimating river basin responses to alternative cropping and/or management strategies. To improve modeling performance compared to previous studies and provide a spatially detailed basis for scenario development, this SWAT Corn Belt application incorporates a greatly refined subwatershed structure based on 12-digit hydrologic units or 'subwatersheds' as defined by the US Geological Service. The model setup, calibration and validation are time-demanding and challenging tasks for these large systems, given the scale intensive data requirements, and the need to ensure the reliability of flow and pollutant load predictions at multiple locations. Thus, the objectives of this study are both to comprehensively describe this large-scale modeling approach, providing estimates of pollution and crop production in the region as well as to present strengths and weaknesses of integrated modeling at such a large scale along with how it can be improved on the basis of the current modeling structure and results. The predictions were based on a semi-automatic hydrologic calibration approach for large-scale and spatially detailed modeling studies, with the use of the Sequential

  17. Integrated water flow model and modflow-farm process: A comparison of theory, approaches, and features of two integrated hydrologic models

    Science.gov (United States)

    Dogrul, Emin C.; Schmid, Wolfgang; Hanson, Randall T.; Kadir, Tariq; Chung, Francis

    2016-01-01

    Effective modeling of conjunctive use of surface and subsurface water resources requires simulation of land use-based root zone and surface flow processes as well as groundwater flows, streamflows, and their interactions. Recently, two computer models developed for this purpose, the Integrated Water Flow Model (IWFM) from the California Department of Water Resources and the MODFLOW with Farm Process (MF-FMP) from the US Geological Survey, have been applied to complex basins such as the Central Valley of California. As both IWFM and MFFMP are publicly available for download and can be applied to other basins, there is a need to objectively compare the main approaches and features used in both models. This paper compares the concepts, as well as the method and simulation features of each hydrologic model pertaining to groundwater, surface water, and landscape processes. The comparison is focused on the integrated simulation of water demand and supply, water use, and the flow between coupled hydrologic processes. The differences in the capabilities and features of these two models could affect the outcome and types of water resource problems that can be simulated.

  18. Integrated design approach of the pebble BeD modular reactor using models

    Energy Technology Data Exchange (ETDEWEB)

    Venter, Pieter J. [Pebble Bed Modular Reactor (Pty) Ltd., P.O. Box 9396, Centurion, 0046 (South Africa)]. E-mail: pieter.venter@pbmr.co.za; Mitchell, Mark N. [Pebble Bed Modular Reactor (Pty) Ltd., P.O. Box 9396, Centurion, 0046 (South Africa)

    2007-07-15

    The pebble bed modular reactor (PBMR) is the first pebble bed reactor that will be utilised in a high temperature direct Brayton cycle configuration. This implies that there are a number of unique features in the PBMR that extend from the German experience base. One of the challenges in the design of the PBMR is developing an understanding of the expected behaviour of the reactor through analyses and simulations and managing the integrated design process between the designers, the physicists and the analysts. This integrated design process is managed through model-based development work. Three-dimensional CAD models are constructed of the components and parts in the reactor. From the CAD models, CFD models, neutronic models, shielding models, FEM models and other thermodynamic models are derived. These models range from very simple models to extremely detailed and complex models. The models are used in legacy software as well as commercial off-the-shelf software. The different models are also used in code-to-code comparisons to verify the results. This paper will briefly discuss the different models and the interaction between the models, and how the models are used in the iterative design process that is used in the development of the reactor at PBMR.

  19. A functional integral approach without slave bosons to the Anderson model

    International Nuclear Information System (INIS)

    Nguyen Ngoc Thuan; Nguyen Toan Thang; Coqblin, B.; Bhattacharjee, A.; Hoang Anh Tuan.

    1994-06-01

    We developed the technique of the functional integral method without slave bosons for the Periodic Anderson Model (PAM) suggested by Sarker for treating the Hubbard Model. This technique allowed us to obtain an analytical expression of Green functions containing U-dependence that is omitted in the formalism with slave bosons. (author). 9 refs

  20. System-of-Systems Approach for Integrated Energy Systems Modeling and Simulation: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Mittal, Saurabh; Ruth, Mark; Pratt, Annabelle; Lunacek, Monte; Krishnamurthy, Dheepak; Jones, Wesley

    2015-08-21

    Today’s electricity grid is the most complex system ever built—and the future grid is likely to be even more complex because it will incorporate distributed energy resources (DERs) such as wind, solar, and various other sources of generation and energy storage. The complexity is further augmented by the possible evolution to new retail market structures that provide incentives to owners of DERs to support the grid. To understand and test new retail market structures and technologies such as DERs, demand-response equipment, and energy management systems while providing reliable electricity to all customers, an Integrated Energy System Model (IESM) is being developed at NREL. The IESM is composed of a power flow simulator (GridLAB-D), home energy management systems implemented using GAMS/Pyomo, a market layer, and hardware-in-the-loop simulation (testing appliances such as HVAC, dishwasher, etc.). The IESM is a system-of-systems (SoS) simulator wherein the constituent systems are brought together in a virtual testbed. We will describe an SoS approach for developing a distributed simulation environment. We will elaborate on the methodology and the control mechanisms used in the co-simulation illustrated by a case study.

  1. Recommendations for Model Driven Paradigms for Integrated Approaches to Cyber Defense

    Science.gov (United States)

    2017-03-06

    Simulation models that we call here “ Business Impact Simulation ” are particularly important for NATO, but simulation models we call here “Attack...Recommendation: The types of simulation models that we call here Business Impact Simulation are particularly important for NATO mission planning, mission...principle-based modeling and simulation are more likely to produce long-term, reusable approaches. A model-driven paradigm is predicated on mechanisms

  2. A model-based approach to attention and sensory integration in postural control of older adults.

    Science.gov (United States)

    Mahboobin, Arash; Loughlin, Patrick J; Redfern, Mark S

    2007-12-18

    We conducted a dual-task experiment that involved information processing (IP) tasks concurrent with postural perturbations to explore the interaction between attention and sensory integration in postural control in young and older adults. A postural control model incorporating sensory integration and the influence of attention was fit to the data, from which parameters were then obtained to quantify the interference of attention on postural control. The model hypothesizes that the cognitive processing and integration of sensory inputs for balance requires time, and that attention influences this processing time, as well as sensory selection by facilitating specific sensory channels. Performing a concurrent IP task had an overall effect on the time delay. Differences in the time delay of the postural control model were found for the older adults. The results suggest enhanced vulnerability of balance processes in older adults to interference from concurrent cognitive IP tasks.

  3. An Object-Oriented Language-Database Integration Model: The Composition-Filters Approach

    NARCIS (Netherlands)

    Aksit, Mehmet; Bergmans, Lodewijk; Vural, S.; Vural, Sinan; Lehrmann Madsen, O.

    1992-01-01

    This paper introduces a new model, based on so-called object-composition filters, that uniformly integrates database-like features into an object-oriented language. The focus is on providing persistent dynamic data structures, data sharing, transactions, multiple views and associative access,

  4. An object-oriented language-database integration model: The composition filters approach

    NARCIS (Netherlands)

    Aksit, Mehmet; Bergmans, Lodewijk; Vural, Sinan; Vural, S.

    1991-01-01

    This paper introduces a new model, based on so-called object-composition filters, that uniformly integrates database-like features into an object-oriented language. The focus is on providing persistent dynamic data structures, data sharing, transactions, multiple views and associative access,

  5. Selecting among five common modelling approaches for integrated environmental assessment and management

    NARCIS (Netherlands)

    Kelly, Rebecca A.; Jakeman, Anthony J.; Barreteau, Olivier; Borsuk, Mark E.; El-Sawah, Sondoss; Hamilton, Serena H.; Henriksen, Hans Jorgen; Kuikka, Sakari; Maier, Holger R.; Rizzoli, Andrea Emilio; van Delden, H.; Voinov, A.

    2013-01-01

    The design and implementation of effective environmental policies need to be informed by a holistic understanding of the system processes (biophysical, social and economic), their complex interactions, and how they respond to various changes. Models, integrating different system processes into a

  6. The economic and environmental value of genetic improvements in fattening pigs: An integrated dynamic model approach.

    Science.gov (United States)

    Niemi, J K; Sevón-Aimonen, M-L; Stygar, A H; Partanen, K

    2015-08-01

    The selection of animals for improved performance affects the profitability of pig fattening and has environmental consequences. The goal of this paper was to examine how changes in genetic and market parameters impact the biophysical (feeding patterns, timing of slaughter, nitrogen excretion) and economic (return per pig space unit) results describing pig fattening in a Finnish farm. The analysis can be viewed as focusing on terminal line breeding goals. An integrated model using recursive stochastic dynamic programming and a biological pig growth model was used to estimate biophysical results and economic values. Combining these models allowed us to provide more accurate estimates for the value of genetic improvement and, thus, provide better feedback to animal breeding programs than the traditional approach, which is based on fixed management patterns. Besides the benchmark scenario, the results were simulated for 5 other scenarios. In each scenario, genotype was improved regarding daily growth potential, carcass lean meat content, or the parameters of the Gompertz growth curve (maturing rate [], adult weight of protein [α], and adult weight of lipid mass []). The change in each parameter was equal to approximately 1 SD genetic improvement (ceteris paribus). Increasing , , daily growth potential, or carcass lean meat content increased the return on pig space unit by €12.60, €7.60, €4.10, or €2.90 per year, respectively, whereas an increase in decreased the return by €3.10. The genetic improvement in and resulted in the highest decrease in nitrogen excretion calculated in total or per kilogram of carcass gain but only under the optimal feeding pattern. Simulated changes in the Gompertz growth function parameters imply greater changes in ADG and lean meat content than changes in scenarios focusing on improving ADG and lean meat content directly. The economic value of genetic improvements as well as the quantity of nitrogen excreted during the fattening

  7. A model for planning the chemical integrated system under uncertainty by the grey programming approach

    DEFF Research Database (Denmark)

    Ren, Jingzheng; Tan, Shiyu; Dong, Lichun

    2013-01-01

    A model to optimize the planning of the chemical integrated system comprised by multi-devices and multi-products has been proposed in this paper. With the objective to make more profits, the traditional model for optimizing production planning has been proposed. The price of chemicals, the market...... be suggested by the decision-makers, and the results of the production planning calculated by the model can help them to achieve their desired target. An actual case has been studied by the proposed methodology, and the proposed methodology can be popularized to other cases....

  8. Integrating modelling and phenotyping approaches to identify and screen complex traits - Illustration for transpiration efficiency in cereals.

    Science.gov (United States)

    Chenu, K; van Oosterom, E J; McLean, G; Deifel, K S; Fletcher, A; Geetika, G; Tirfessa, A; Mace, E S; Jordan, D R; Sulman, R; Hammer, G L

    2018-02-21

    Following advances in genetics, genomics, and phenotyping, trait selection in breeding is limited by our ability to understand interactions within the plants and with their environments, and to target traits of most relevance for the target population of environments. We propose an integrated approach that combines insights from crop modelling, physiology, genetics, and breeding to identify traits valuable for yield gain in the target population of environments, develop relevant high-throughput phenotyping platforms, and identify genetic controls and their values in production environments. This paper uses transpiration efficiency (biomass produced per unit of water used) as an example of a complex trait of interest to illustrate how the approach can guide modelling, phenotyping, and selection in a breeding program. We believe that this approach, by integrating insights from diverse disciplines, can increase the resource use efficiency of breeding programs for improving yield gains in target populations of environments.

  9. A data integration approach for cell cycle analysis oriented to model simulation in systems biology

    Directory of Open Access Journals (Sweden)

    Mosca Ettore

    2007-08-01

    Full Text Available Abstract Background The cell cycle is one of the biological processes most frequently investigated in systems biology studies and it involves the knowledge of a large number of genes and networks of protein interactions. A deep knowledge of the molecular aspect of this biological process can contribute to making cancer research more accurate and innovative. In this context the mathematical modelling of the cell cycle has a relevant role to quantify the behaviour of each component of the systems. The mathematical modelling of a biological process such as the cell cycle allows a systemic description that helps to highlight some features such as emergent properties which could be hidden when the analysis is performed only from a reductionism point of view. Moreover, in modelling complex systems, a complete annotation of all the components is equally important to understand the interaction mechanism inside the network: for this reason data integration of the model components has high relevance in systems biology studies. Description In this work, we present a resource, the Cell Cycle Database, intended to support systems biology analysis on the Cell Cycle process, based on two organisms, yeast and mammalian. The database integrates information about genes and proteins involved in the cell cycle process, stores complete models of the interaction networks and allows the mathematical simulation over time of the quantitative behaviour of each component. To accomplish this task, we developed, a web interface for browsing information related to cell cycle genes, proteins and mathematical models. In this framework, we have implemented a pipeline which allows users to deal with the mathematical part of the models, in order to solve, using different variables, the ordinary differential equation systems that describe the biological process. Conclusion This integrated system is freely available in order to support systems biology research on the cell cycle and

  10. A Bayesian network approach to knowledge integration and representation of farm irrigation: 1. Model development

    Science.gov (United States)

    Wang, Q. J.; Robertson, D. E.; Haines, C. L.

    2009-02-01

    Irrigation is important to many agricultural businesses but also has implications for catchment health. A considerable body of knowledge exists on how irrigation management affects farm business and catchment health. However, this knowledge is fragmentary; is available in many forms such as qualitative and quantitative; is dispersed in scientific literature, technical reports, and the minds of individuals; and is of varying degrees of certainty. Bayesian networks allow the integration of dispersed knowledge into quantitative systems models. This study describes the development, validation, and application of a Bayesian network model of farm irrigation in the Shepparton Irrigation Region of northern Victoria, Australia. In this first paper we describe the process used to integrate a range of sources of knowledge to develop a model of farm irrigation. We describe the principal model components and summarize the reaction to the model and its development process by local stakeholders. Subsequent papers in this series describe model validation and the application of the model to assess the regional impact of historical and future management intervention.

  11. A data-model integration approach toward improved understanding on wetland functions and hydrological benefits at the catchment scale

    Science.gov (United States)

    Yeo, I. Y.; Lang, M.; Lee, S.; Huang, C.; Jin, H.; McCarty, G.; Sadeghi, A.

    2017-12-01

    The wetland ecosystem plays crucial roles in improving hydrological function and ecological integrity for the downstream water and the surrounding landscape. However, changing behaviours and functioning of wetland ecosystems are poorly understood and extremely difficult to characterize. Improved understanding on hydrological behaviours of wetlands, considering their interaction with surrounding landscapes and impacts on downstream waters, is an essential first step toward closing the knowledge gap. We present an integrated wetland-catchment modelling study that capitalizes on recently developed inundation maps and other geospatial data. The aim of the data-model integration is to improve spatial prediction of wetland inundation and evaluate cumulative hydrological benefits at the catchment scale. In this paper, we highlight problems arising from data preparation, parameterization, and process representation in simulating wetlands within a distributed catchment model, and report the recent progress on mapping of wetland dynamics (i.e., inundation) using multiple remotely sensed data. We demonstrate the value of spatially explicit inundation information to develop site-specific wetland parameters and to evaluate model prediction at multi-spatial and temporal scales. This spatial data-model integrated framework is tested using Soil and Water Assessment Tool (SWAT) with improved wetland extension, and applied for an agricultural watershed in the Mid-Atlantic Coastal Plain, USA. This study illustrates necessity of spatially distributed information and a data integrated modelling approach to predict inundation of wetlands and hydrologic function at the local landscape scale, where monitoring and conservation decision making take place.

  12. A model for planning the chemical integrated system under uncertainty by the grey programming approach

    DEFF Research Database (Denmark)

    Ren, Jingzheng; Tan, Shiyu; Dong, Lichun

    2013-01-01

    A model to optimize the planning of the chemical integrated system comprised by multi-devices and multi-products has been proposed in this paper. With the objective to make more profits, the traditional model for optimizing production planning has been proposed. The price of chemicals, the market...... demand, and the production capacity have been considered as mutative variables, then an improved model in which some parameters are not constant has been developed and a new method to solve the grey linear programming has been proposed. In the grey programming model, the value of credibility can...... be suggested by the decision-makers, and the results of the production planning calculated by the model can help them to achieve their desired target. An actual case has been studied by the proposed methodology, and the proposed methodology can be popularized to other cases....

  13. Identifying victims of workplace bullying by integrating traditional estimation approaches into a latent class cluster model.

    Science.gov (United States)

    Leon-Perez, Jose M; Notelaers, Guy; Arenas, Alicia; Munduate, Lourdes; Medina, Francisco J

    2014-05-01

    Research findings underline the negative effects of exposure to bullying behaviors and document the detrimental health effects of being a victim of workplace bullying. While no one disputes its negative consequences, debate continues about the magnitude of this phenomenon since very different prevalence rates of workplace bullying have been reported. Methodological aspects may explain these findings. Our contribution to this debate integrates behavioral and self-labeling estimation methods of workplace bullying into a measurement model that constitutes a bullying typology. Results in the present sample (n = 1,619) revealed that six different groups can be distinguished according to the nature and intensity of reported bullying behaviors. These clusters portray different paths for the workplace bullying process, where negative work-related and person-degrading behaviors are strongly intertwined. The analysis of the external validity showed that integrating previous estimation methods into a single measurement latent class model provides a reliable estimation method of workplace bullying, which may overcome previous flaws.

  14. The circumplex model of affect: an integrative approach to affective neuroscience, cognitive development, and psychopathology.

    Science.gov (United States)

    Posner, Jonathan; Russell, James A; Peterson, Bradley S

    2005-01-01

    The circumplex model of affect proposes that all affective states arise from cognitive interpretations of core neural sensations that are the product of two independent neurophysiological systems. This model stands in contrast to theories of basic emotions, which posit that a discrete and independent neural system subserves every emotion. We propose that basic emotion theories no longer explain adequately the vast number of empirical observations from studies in affective neuroscience, and we suggest that a conceptual shift is needed in the empirical approaches taken to the study of emotion and affective psychopathologies. The circumplex model of affect is more consistent with many recent findings from behavioral, cognitive neuroscience, neuroimaging, and developmental studies of affect. Moreover, the model offers new theoretical and empirical approaches to studying the development of affective disorders as well as the genetic and cognitive underpinnings of affective processing within the central nervous system.

  15. The Functional Model Approach to the Consulting for Vertically - Integrated Construction Group

    Directory of Open Access Journals (Sweden)

    Pimenova Anna

    2016-01-01

    Full Text Available Managerial decision making in the framework of functional modeling of the consulting process have a direct effect on other business - processes of vertically - integrated group of construction companies. As a result, the experience of consulting companies tends to be used for the making managerial solutions. Consultancy is known as one of the most complicated types of buisiness process. It requires a huge and deep examines and researches of targeting area, therefore need to be provided with special methodology, included internal standards of the consulting companies. Correct methodological support, planning process and implementation of managerial solutions should be based on the survey of the direct and inverse connections and interdependence of all group’s business – processes. Functional - process modeling of the vertically - integrated construction group could be considered as an instrument of examination and analysis of the issue how the managerial solution impact on the business-process for the construction group functioning. The main result of the research is the formalized process-oriented model – prototype of the business - processes of vertically - integrated group of construction companies.

  16. A hybrid approach to survival model building using integration of clinical and molecular information in censored data.

    Science.gov (United States)

    Choi, Ickwon; Kattan, Michael W; Wells, Brian J; Yu, Changhong

    2012-01-01

    In medical society, the prognostic models, which use clinicopathologic features and predict prognosis after a certain treatment, have been externally validated and used in practice. In recent years, most research has focused on high dimensional genomic data and small sample sizes. Since clinically similar but molecularly heterogeneous tumors may produce different clinical outcomes, the combination of clinical and genomic information, which may be complementary, is crucial to improve the quality of prognostic predictions. However, there is a lack of an integrating scheme for clinic-genomic models due to the P ≥ N problem, in particular, for a parsimonious model. We propose a methodology to build a reduced yet accurate integrative model using a hybrid approach based on the Cox regression model, which uses several dimension reduction techniques, L₂ penalized maximum likelihood estimation (PMLE), and resampling methods to tackle the problem. The predictive accuracy of the modeling approach is assessed by several metrics via an independent and thorough scheme to compare competing methods. In breast cancer data studies on a metastasis and death event, we show that the proposed methodology can improve prediction accuracy and build a final model with a hybrid signature that is parsimonious when integrating both types of variables.

  17. Waste Management: An integrated modeling approach for analyzing change in NWC production processes

    International Nuclear Information System (INIS)

    Christensen, D.C.; Sohn, C.L.; Helm, T.M.; Farish, T.J.; Reid, R.A.

    1991-01-01

    A problem-driven, integrated modeling, decision-support framework has been conceptualized to aid a team of experts determine the set of evolving technologies that should receive additional developmental support. This conceptual framework utilizes a variety of decision aiding models including Flowsheeting, Analytical Hierarchy Process, Linear and Goal Programming, and Object-Oriented Discrete Event Simulation. A number of the technologies under consideration are strong candidates to overcome current plutonium processing problems so that effective technology will be available for implementation in Complex 21. Complex 21 is a participatory, inter-installation planning effort sponsored by US DOE to consolidate and revitalize the nuclear weapons complex facilities by the 21st century. A computer-based dynamic simulation model has been constructed that will allow testing of alternative combinations of developing technologies. The modeling of new configurations of technologies under a number of different operating conditions and material flow assumptions provides information needed for effective decision making for Complex 21. 4 figs

  18. Modeling and Simulation Resource Repository (MSRR)(System Engineering/Integrated M&S Management Approach

    Science.gov (United States)

    Milroy, Audrey; Hale, Joe

    2006-01-01

    NASA s Exploration Systems Mission Directorate (ESMD) is implementing a management approach for modeling and simulation (M&S) that will provide decision-makers information on the model s fidelity, credibility, and quality, including the verification, validation and accreditation information. The NASA MSRR will be implemented leveraging M&S industry best practices. This presentation will discuss the requirements that will enable NASA to capture and make available the "meta data" or "simulation biography" data associated with a model. The presentation will also describe the requirements that drive how NASA will collect and document relevant information for models or suites of models in order to facilitate use and reuse of relevant models and provide visibility across NASA organizations and the larger M&S community.

  19. Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach.

    Science.gov (United States)

    Ng, Candy K S; Osuna-Sanchez, Hector; Valéry, Eric; Sørensen, Eva; Bracewell, Daniel G

    2012-06-15

    An integrated experimental and modeling approach for the design of high productivity protein A chromatography is presented to maximize productivity in bioproduct manufacture. The approach consists of four steps: (1) small-scale experimentation, (2) model parameter estimation, (3) productivity optimization and (4) model validation with process verification. The integrated use of process experimentation and modeling enables fewer experiments to be performed, and thus minimizes the time and materials required in order to gain process understanding, which is of key importance during process development. The application of the approach is demonstrated for the capture of antibody by a novel silica-based high performance protein A adsorbent named AbSolute. In the example, a series of pulse injections and breakthrough experiments were performed to develop a lumped parameter model, which was then used to find the best design that optimizes the productivity of a batch protein A chromatographic process for human IgG capture. An optimum productivity of 2.9 kg L⁻¹ day⁻¹ for a column of 5mm diameter and 8.5 cm length was predicted, and subsequently verified experimentally, completing the whole process design approach in only 75 person-hours (or approximately 2 weeks). Copyright © 2012 Elsevier B.V. All rights reserved.

  20. Integrated approaches to modeling the organic and inorganic atmospheric aerosol components

    Science.gov (United States)

    Koo, Bonyoung; Ansari, Asif S.; Pandis, Spyros N.

    A series of modeling approaches for the description of the dynamic behavior of secondary organic aerosol (SOA) components and their interactions with inorganics is presented. The models employ a lumped species approach based on available smog chamber studies and the UNIquac Functional-group Activity Coefficient (UNIFAC) method to estimate SOA water absorption. The additional water due to SOA species can change the partitioning behavior of the semi-volatile inorganics. Primary organic particles significantly influence the SOA partitioning between gas and aerosol phases. The SOA size distribution predicted by a bulk equilibrium approach is biased toward smaller sizes compared with that of a fully dynamic model. An improved weighting scheme for the bulk equilibrium approach is proposed in this work and is shown to minimize this discrepancy. SOA is predicted to increase the total aerosol water in Southern California by 2-13% depending on conditions. However, the effect of SOA water absorption on aerosol nitrate is insignificant for all the cases studied in Southern California.

  1. An Integrated Approach Linking Process to Structural Modeling With Microstructural Characterization for Injections-Molded Long-Fiber Thermoplastics

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Ba Nghiep; Bapanapalli, Satish K.; Smith, Mark T.; Kunc, Vlastimil; Frame, Barbara; Norris, Robert E.; Phelps, Jay; Tucker III, Charles L.; Jin, Xiaoshi; Wang, Jin

    2008-09-01

    The objective of our work is to enable the optimum design of lightweight automotive structural components using injection-molded long fiber thermoplastics (LFTs). To this end, an integrated approach that links process modeling to structural analysis with experimental microstructural characterization and validation is developed. First, process models for LFTs are developed and implemented into processing codes (e.g. ORIENT, Moldflow) to predict the microstructure of the as-formed composite (i.e. fiber length and orientation distributions). In parallel, characterization and testing methods are developed to obtain necessary microstructural data to validate process modeling predictions. Second, the predicted LFT composite microstructure is imported into a structural finite element analysis by ABAQUS to determine the response of the as-formed composite to given boundary conditions. At this stage, constitutive models accounting for the composite microstructure are developed to predict various types of behaviors (i.e. thermoelastic, viscoelastic, elastic-plastic, damage, fatigue, and impact) of LFTs. Experimental methods are also developed to determine material parameters and to validate constitutive models. Such a process-linked-structural modeling approach allows an LFT composite structure to be designed with confidence through numerical simulations. Some recent results of our collaborative research will be illustrated to show the usefulness and applications of this integrated approach.

  2. Developing a New Integrated Model to improve the using of Classical Approach in Designing Management Information Systems

    OpenAIRE

    Mohammad M M Abu Omar; Khairul Anuar Abdullah

    2015-01-01

    Management information system (MIS) is used to solve management problems in the practical life, the designing and building of the management information systems is done by using one of the systems development methodologies. Classical approach is one of these methodologies which still suffer from some critical problems when it is used in designing and building the management information systems, it consumes more time and cost during its life cycle. This paper develops a new integrated model to...

  3. A Distributed Model Predictive Control approach for the integration of flexible loads, storage and renewables

    DEFF Research Database (Denmark)

    Ferrarini, Luca; Mantovani, Giancarlo; Costanzo, Giuseppe Tommaso

    2014-01-01

    This paper presents an innovative solution based on distributed model predictive controllers to integrate the control and management of energy consumption, energy storage, PV and wind generation at customer side. The overall goal is to enable an advanced prosumer to autoproduce part of the energy...... he needs with renewable sources and, at the same time, to optimally exploit the thermal and electrical storages, to trade off its comfort requirements with different pricing schemes (including real-time pricing), and apply optimal control techniques rather than sub-optimal heuristics....

  4. Integrating socio-economical dimensions in the ICRP cost-benefit model (a theoretical approach)

    International Nuclear Information System (INIS)

    Lochard, Jacques.

    1981-09-01

    This report aims at analysing, from a methodological point of view, the main problems associated with the integration of socio-economical dimensions in the cost-benefit model recommended by the ICRP in its publication no. 26. After recalling the basic principles of cost-benefit analysis, the elements to be retained in the objective function characterizing the analysis, and the question of the social benefit definitions are discussed. The theory of social surplus with an illustration taken from the radiological protection field is presented [fr

  5. Detecting changes in water limitation in the West using integrated ecosystem modeling approaches

    Science.gov (United States)

    Poulter, B.; Hoy, J.; Emmett, K.; Cross, M.; Maneta, M. P.; Al-Chokhachy, R.

    2016-12-01

    Water in the western United States is the critical currency for determining a range of ecosystem services, such as wildlife habitat, carbon sequestration, and timber and water resources for an expanding human population. The current generation of catchment models trades a detailed representation of hydrologic processes for a generalization of vegetation processes and thus ignores many land-surface feedbacks that are driven by physiological responses to atmospheric CO2 and changes in vegetation structure following disturbance and climate change. Here we demonstrate how catchment scale modeling can better couple vegetation dynamics and disturbance processes to reconstruct historic streamflow, stream temperature and vegetation greening for the Greater Yellowstone Ecosystem. Using a new catchment routing model coupled to the LPJ-GUESS dynamic global vegetation model, simulations are made at 1 km spatial resolution using two different climate products. Decreased winter snowpack has led to increasing spring runoff and declines in summertime slow, and increasing the likelihood that stream temperature exceeds thresholds for cold-water fish growth. Since the mid-1980s, vegetation greening is projected by both the model and detected from space-borne normalized difference vegetation index observations. These greening trends are superimposed on a landscape matrix defined by frequent disturbance and intensive land management, making the climate and CO2 fingerprint difficult to discern. Integrating dynamical vegetation models with in-situ and spaceborne measurements to understand and interpret catchment-scale trends in water availability has potential to better disentangle historical climate, CO2, and human drivers and their ecosystem consequences.

  6. A new approach to integrate seismic and production data in reservoir models

    Energy Technology Data Exchange (ETDEWEB)

    Ouenes, A.; Chawathe, A.; Weiss, W. [New Mexico Tech, Socorro, NM (United States)] [and others

    1997-08-01

    A great deal of effort is devoted to reducing the uncertainties in reservoir modeling. For example, seismic properties are used to improve the characterization of interwell properties by providing porosity maps constrained to seismic impedance. Another means to reduce uncertainties is to constrain the reservoir model to production data. This paper describes a new approach where the production and seismic data are simultaneously used to reduce the uncertainties. In this new approach, the primary geologic parameter that controls reservoir properties is identified. Next, the geophysical parameter that is sensitive to the dominant geologic parameter is determined. Then the geology and geophysics are linked using analytic correlations. Unfortunately, the initial guess resulted in a reservoir model that did not match the production history. Since the time required for trial and error matching of production history is exorbitant, an automatic history matching method based on a fast optimization method was used to find the correlating parameters. This new approach was illustrated with an actual field in the Williston Basin. Upscalling problems do not arise since the scale is imposed by the size of the seismic bin (66m, 219 ft) which is the size of the simulator gridblocks.

  7. A Novel Integrated Approach to Modelling of Depletion-Induced Change in Full Permeability Tensor of Naturally Fractured Reservoirs

    Directory of Open Access Journals (Sweden)

    Zahra Izadi

    2014-12-01

    Full Text Available More than half of all hydrocarbon reservoirs are Naturally Fractured Reservoirs (NFRs, in which production forecasting is a complicated function of fluid flow in a fracture-matrix system. Modelling of fluid flow in NFRs is challenging due to formation heterogeneity and anisotropy. Stress sensitivity and depletion effect on already-complex reservoir permeability add to the sophistication. Horizontal permeability anisotropy and stress sensitivity are often ignored or inaccurately taken into account when simulating fluid flow in NFRs. The aim of this paper is to present an integrated approach for evaluating the dynamic and true anisotropic nature of permeability in naturally fractured reservoirs. Among other features, this approach considers the effect of reservoir depletion on reservoir permeability tensor, allowing more realistic production forecasts. In this approach the NFR is discretized into grids for which an analytical model yields full permeability tensors. Then, fluid flow is modelled using the finite-element method to obtain pore-pressure distribution within the reservoir. Next, another analytical model evaluates the change in the aperture of individual fractures as a function of effective stress and rock mechanical properties. The permeability tensor of each grid is then updated based on the apertures obtained for the current time step. The integrated model proceeds according to the next prescribed time increments.

  8. Integrating adaptive behaviour in large-scale flood risk assessments: an Agent-Based Modelling approach

    Science.gov (United States)

    Haer, Toon; Aerts, Jeroen

    2015-04-01

    Between 1998 and 2009, Europe suffered over 213 major damaging floods, causing 1126 deaths, displacing around half a million people. In this period, floods caused at least 52 billion euro in insured economic losses making floods the most costly natural hazard faced in Europe. In many low-lying areas, the main strategy to cope with floods is to reduce the risk of the hazard through flood defence structures, like dikes and levees. However, it is suggested that part of the responsibility for flood protection needs to shift to households and businesses in areas at risk, and that governments and insurers can effectively stimulate the implementation of individual protective measures. However, adaptive behaviour towards flood risk reduction and the interaction between the government, insurers, and individuals has hardly been studied in large-scale flood risk assessments. In this study, an European Agent-Based Model is developed including agent representatives for the administrative stakeholders of European Member states, insurers and reinsurers markets, and individuals following complex behaviour models. The Agent-Based Modelling approach allows for an in-depth analysis of the interaction between heterogeneous autonomous agents and the resulting (non-)adaptive behaviour. Existing flood damage models are part of the European Agent-Based Model to allow for a dynamic response of both the agents and the environment to changing flood risk and protective efforts. By following an Agent-Based Modelling approach this study is a first contribution to overcome the limitations of traditional large-scale flood risk models in which the influence of individual adaptive behaviour towards flood risk reduction is often lacking.

  9. Planning Emergency Shelters for Urban Disaster Resilience: An Integrated Location-Allocation Modeling Approach

    Directory of Open Access Journals (Sweden)

    Laijun Zhao

    2017-11-01

    Full Text Available In recent years, extreme natural hazards threaten cities more than ever due to contemporary society’s high vulnerability in cities. Hence, local governments need to implement risk mitigation and disaster operation management to enhance disaster resilience in cities. Transforming existing open spaces within cities into emergency shelters is an effective method of providing essential life support and an agent of recovery in the wake of disasters. Emergency shelters planning must identify suitable locations for shelters and reasonably allocate evacuees to those shelters. In this paper, we first consider both the buildings’ post-disaster condition and the human choice factor that affect evacuees’ decision, and propose a forecasting method to estimate the time-varying shelter demand. Then we formulate an integrated location-allocation model that is used sequentially: an emergency shelter location model to satisfy the time-varying shelter demand in a given urban area with a goal of minimizing the total setup cost of locating the shelters and an allocation model that allocates the evacuees to shelters with a goal of minimizing their total evacuation distance. We also develop an efficient algorithm to solve the model. Finally, we propose an emergency shelters planning based on a case study of Shanghai, China.

  10. A comparison of Capri and SEAMLESS-IFas Integrated Modelling Systems, Chapter 11 in Environmental and Agricultural Modelling: Integrated Approaches for Policy Impact Assessement

    NARCIS (Netherlands)

    Britz, W.; Perez Dominguez, I.; Heckelei, T.

    2010-01-01

    SEAMLESS-IF and CAPRI are both integrated agricultural modelling systems for policy impact assessment at EU level, linking model components across scales and between the economic and bio-physical domains. However, the overall design, focus and representation of agricultural sub-systems vary between

  11. [The GIPSY-RECPAM model: a versatile approach for integrated evaluation in cardiologic care].

    Science.gov (United States)

    Carinci, F

    2009-01-01

    Tree-structured methodology applied for the GISSI-PSICOLOGIA project, although performed in the framework of earliest GISSI studies, represents a powerful tool to analyze different aspects of cardiologic care. The GISSI-PSICOLOGIA project has delivered a novel methodology based on the joint application of psychometric tools and sophisticated statistical techniques. Its prospective use could allow building effective epidemiological models relevant to the prognosis of the cardiologic patient. The various features of the RECPAM method allow a versatile use in the framework of modern e-health projects. The study used the Cognitive Behavioral Assessment H Form (CBA-H) psychometrics scales. The potential for its future application in the framework of Italian cardiology is relevant and particularly indicated to assist planning of systems for integrated care and routine evaluation of the cardiologic patient.

  12. Integrated Approach to Competitive Advantage

    Directory of Open Access Journals (Sweden)

    Edita Ragelskaja

    2011-07-01

    Full Text Available Environmental changes and globalization of markets make an impact on intense competition in almost all business sectors. Evolutionary changes influence companies to learn, adequately react, adapt to environmental changes and to change themselves. Such a situation has revealed the problems of competitive advan­tage of industry companies. Therefore the focus to the factors impacting competitive advantage is seen as timely and relevant. The authors of the paper analyze approaches to competitive advantage and the factors impacting competitive advantage. The integrated model of competitive advantage is proposed in the paper.Article in Lithuanian

  13. An Integrated Hydrologic Modeling Approach to Cesium-137 Transport in Forested Fukushima Watersheds

    Science.gov (United States)

    Siirila-Woodburn, E. R.; Steefel, C. I.; Williams, K. H.; Birkholzer, J. T.

    2015-12-01

    The 2011 Fukushima Daiichi Nuclear Power Plant (FDNPP) accident in Japan resulted in a significant dissemination of cesium-137 (Cs-137) over a wide area west of the plant, including the contamination of many watersheds and the subsequent evacuation of many communities. Today approximately 90% of on-land Cs-137 fallout following the accident resides in the upper 5 cm of forest soils. While this can be partially attributed to the forested composition of the prefecture (70%), there is also difficulty in cleanup efforts in these regions due to a lack of understanding and predictive capability of radioisotopes transport at the catchment to watershed scale. Subsequently, there is an uncertain, but likely long-term impact on local communities with implications for the use of nuclear energy use worldwide. Due to the complex nature of forest eco-hydrology, sophisticated modeling tools to accurately predict Cs-137 fluxes across different spatial and temporal scales are required. High fidelity, high resolution numerical modeling techniques in conjunction with parallel high performance computing is required to accurately determine transport and feedbacks in these complex systems. To better understand the fundamental transport of Cs-137, a watershed near the FDNPP is modeled with an integrated hydrologic model that includes variably saturated groundwater and overland flow in addition to atmospheric and vegetative processes via a coupled land surface model. Of specific interest is the impact of land cover type on hydrologic flow in the area, which will likely play an important role in erosion patterns and the consequent transport of Cs-137 strongly sorbed to surface soils. Risk management practices (for example, passive remediation versus active remediation such as targeted logging) for two principal tree types (evergreen and deciduous) are informed given the simulated responses to flow patterns assuming different quantities and spatial distribution patterns of each tree type.

  14. An integrated hydrological modeling approach for detection and attribution of climatic and human impacts on coastal water resources

    Science.gov (United States)

    Feng, Dapeng; Zheng, Yi; Mao, Yixin; Zhang, Aijing; Wu, Bin; Li, Jinguo; Tian, Yong; Wu, Xin

    2018-02-01

    Water resources in coastal areas can be profoundly influenced by both climate change and human activities. These climatic and human impacts are usually intertwined and difficult to isolate. This study developed an integrated model-based approach for detection and attribution of climatic and human impacts and applied this approach to the Luanhe Plain, a typical coastal area in northern China. An integrated surface water-groundwater model was developed for the study area using GSFLOW (coupled groundwater and surface-water flow). Model calibration and validation were performed for background years between 1975 and 2000. The variation in water resources between the 1980s and 1990s was then quantitatively attributed to climate variability, groundwater pumping and changes in upstream inflow. Climate scenarios for future years (2075-2100) were also developed by downscaling the projections in CMIP5. Potential water resource responses to climate change, as well as their uncertainty, were then investigated through integrated modeling. The study results demonstrated the feasibility and value of the integrated modeling-based analysis for water resource management in areas with complex surface water-groundwater interaction. Specific findings for the Luanhe Plain included the following: (1) During the historical period, upstream inflow had the most significant impact on river outflow to the sea, followed by climate variability, whereas groundwater pumping was the least influential. (2) The increase in groundwater pumping had a dominant influence on the decline in groundwater change, followed by climate variability. (3) Synergetic and counteractive effects among different impacting factors, while identified, were not significant, which implied that the interaction among different factors was not very strong in this case. (4) It is highly probable that future climate change will accelerate groundwater depletion in the study area, implying that strict regulations for groundwater

  15. An Integrated Approach to Modeling Solar Electric Propulsion Vehicles During Long Duration, Near-Earth Orbit Transfers

    Science.gov (United States)

    Smith, David A.; Hojnicki, Jeffrey S.; Sjauw, Waldy K.

    2014-01-01

    Recent NASA interest in utilizing solar electronic propulsion (SEP) technology to transfer payloads, e.g. from low-Earth orbit (LEO) to higher energy geostationary-Earth orbit (GEO) or to Earth escape, has necessitated the development of high fidelity SEP vehicle models and simulations. These models and simulations need to be capable of capturing vehicle dynamics and sub-system interactions experienced during the transfer trajectories which are typically accomplished with continuous-burn (potentially interrupted by solar eclipse), long duration "spiral out" maneuvers taking several months or more to complete. This paper presents details of an integrated simulation approach achieved by combining a high fidelity vehicle simulation code with a detailed solar array model. The combined simulation tool gives researchers the functionality to study the integrated effects of various vehicle sub-systems (e.g. vehicle guidance, navigation and control (GN&C), electric propulsion system (EP)) with time varying power production. Results from a simulation model of a vehicle with a 50 kW class SEP system using the integrated tool are presented and compared to the results from another simulation model employing a 50 kW end-of-life (EOL) fixed power level assumption. These models simulate a vehicle under three degree of freedom dynamics (i.e. translational dynamics only) and include the effects of a targeting guidance algorithm (providing a "near optimal" transfer) during a LEO to near Earth escape (C (sub 3) = -2.0 km (sup 2) / sec (sup -2) spiral trajectory. The presented results include the impact of the fully integrated, time-varying solar array model (e.g. cumulative array degradation from traversing the Van Allen belts, impact of solar eclipses on the vehicle and the related temperature responses in the solar arrays due to operating in the Earth's thermal environment, high fidelity array power module, etc.); these are used to assess the impact on vehicle performance (i

  16. An eight component decision-making model for problem gambling: a systems approach to stimulate integrative research.

    Science.gov (United States)

    Nussbaum, David; Honarmand, Kimia; Govoni, Richard; Kalahani-Bargis, Martina; Bass, Stephanie; Ni, Xinqun; Laforge, Kaitlyn; Burden, Andrea; Romero, Kristoffer; Basarke, Sonya; Courbasson, Christine; Deamond, Wade

    2011-12-01

    Problem Gambling (PG) represents a serious problem for affected individuals, their families and society in general. Previous approaches to understanding PG have been confined to only a subset of the psychobiological factors influencing PG. We present a model that attempts to integrate potential causal factors across levels of organization, providing empirical evidence from the vast literature on PG and complimentary literatures in decision-making and addiction. The model posits that components are arranged systematically to bias decisions in favor of either immediately approaching or avoiding targets affording the opportunity for immediate reward. Dopamine, Testosterone and Endogenous Opioids favor immediate approach, while Serotonin and Cortisol favor inhibition. Glutamate is involved in associative learning between stimuli and promotes the approach response through its link to the DA reward system. GABA functions to monitor performance and curb impulsive decision-making. Finally, while very high levels of Norepinephrine can induce arousal to an extent that is detrimental to sound decision-making, the reactivity of the Norepinephrine system and its effects of Cortisol levels can shift the focus towards long-term consequences, thereby inhibiting impulsive decisions. Empirical evidence is provided showing the effects of each component on PG and decision-making across behavioural, neuropsychological, functional neuroimaging and genetic levels. Last, an effect size analysis of the growing pharmacotherapy literature is presented. It is hoped that this model will stimulate multi-level research to solidify our comprehension of biased decision-making in PG and suggest pharmacological and psychological approaches to treatment.

  17. An Integrated Modeling Approach for Forecasting Long-Term Energy Demand in Pakistan

    Directory of Open Access Journals (Sweden)

    Syed Aziz Ur Rehman

    2017-11-01

    Full Text Available Energy planning and policy development require an in-depth assessment of energy resources and long-term demand forecast estimates. Pakistan, unfortunately, lacks reliable data on its energy resources as well do not have dependable long-term energy demand forecasts. As a result, the policy makers could not come up with an effective energy policy in the history of the country. Energy demand forecast has attained greatest ever attention in the perspective of growing population and diminishing fossil fuel resources. In this study, Pakistan’s energy demand forecast for electricity, natural gas, oil, coal and LPG across all the sectors of the economy have been undertaken. Three different energy demand forecasting methodologies, i.e., Autoregressive Integrated Moving Average (ARIMA, Holt-Winter and Long-range Energy Alternate Planning (LEAP model were used. The demand forecast estimates of each of these methods were compared using annual energy demand data. The results of this study suggest that ARIMA is more appropriate for energy demand forecasting for Pakistan compared to Holt-Winter model and LEAP model. It is estimated that industrial sector’s demand shall be highest in the year 2035 followed by transport and domestic sectors. The results further suggest that energy fuel mix will change considerably, such that oil will be the most highly consumed energy form (38.16% followed by natural gas (36.57%, electricity (16.22%, coal (7.52% and LPG (1.52% in 2035. In view of higher demand forecast of fossil fuels consumption, this study recommends that government should take the initiative for harnessing renewable energy resources for meeting future energy demand to not only avert huge import bill but also achieving energy security and sustainability in the long run.

  18. Integrated Approach Using Condition Monitoring and Modeling to Investigate Wind Turbine Gearbox Design: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Sheng, S.; Guo, Y.

    2015-03-01

    Vibration-based condition monitoring (CM) of geared utility-scale turbine drivetrains has been used by the wind industry to help improve operation and maintenance (O&M) practices, increase turbine availability, and reduce O&M cost. This study is a new endeavor that integrates the vibration-based CM technique with wind turbine gearbox modeling to investigate various gearbox design options. A teamof researchers performed vibration-based CM measurements on a damaged wind turbine gearbox with a classic configuration, (i.e., one planetary stage and two parallel stages). We observed that the acceleration amplitudes around the first-order sidebands of the intermediate stage gear set meshing frequency were much lower than that measured at the high-speed gear set, and similar difference wasalso observed in a healthy gearbox. One factor for a reduction at the intermediate stage gear set is hypothesized to be the soft sun-spline configuration in the test gearbox. To evaluate this hypothesis, a multibody dynamic model of the healthy test gearbox was first developed and validated. Relative percent difference of the first-order sidebands--of the high-speed and intermediate stagegear-meshing frequencies--in the soft and the rigid sun spline configurations were compared. The results verified that the soft sun-spline configuration can reduce the sidebands of the intermediate stage gear set and also the locating bearing loads. The study demonstrates that combining vibration-based CM with appropriate modeling can provide insights for evaluating different wind turbinegearbox design options.

  19. An Integrated Model for Simulating Regional Water Resources Based on Total Evapotranspiration Control Approach

    Directory of Open Access Journals (Sweden)

    Jianhua Wang

    2014-01-01

    Full Text Available Total evapotranspiration and water consumption (ET control is considered an efficient method for water management. In this study, we developed a water allocation and simulation (WAS model, which can simulate the water cycle and output different ET values for natural and artificial water use, such as crop evapotranspiration, grass evapotranspiration, forest evapotranspiration, living water consumption, and industry water consumption. In the calibration and validation periods, a “piece-by-piece” approach was used to evaluate the model from runoff to ET data, including the remote sensing ET data and regional measured ET data, which differ from the data from the traditional hydrology method. We applied the model to Tianjin City, China. The Nash-Sutcliffe efficiency (Ens of the runoff simulation was 0.82, and its regression coefficient R2 was 0.92. The Nash-Sutcliffe Efficiency (Ens of regional total ET simulation was 0.93, and its regression coefficient R2 was 0.98. These results demonstrate that ET of irrigation lands is the dominant part, which accounts for 53% of the total ET. The latter is also a priority in ET control for water management.

  20. Beyond biological monitoring: an integrated approach

    NARCIS (Netherlands)

    Verdonschot, P.F.M.

    2006-01-01

    Concluding discussion ‘Beyond Biological Monitoring: An Integrated Approach’ of the section New tools and strategies for river ecology evaluation – presents decision making on what constitutes a significant environmental change; predictive modelling approaches; evaluating fluvial functioning (FFI),

  1. Drought resilience across ecologically dominant species: An experiment-model integration approach

    Science.gov (United States)

    Felton, A. J.; Warren, J.; Ricciuto, D. M.; Smith, M. D.

    2017-12-01

    Poorly understood are the mechanisms contributing to variability in ecosystem recovery following drought. Grasslands of the central U.S. are ecologically and economically important ecosystems, yet are also highly sensitive to drought. Although characteristics of these ecosystems change across gradients of temperature and precipitation, a consistent feature among these systems is the presence of highly abundant, dominant grass species that control biomass production. As a result, the incorporation of these species' traits into terrestrial biosphere models may constrain predictions amid increases in climatic variability. Here we report the results of a modeling-experiment (MODEX) research approach. We investigated the physiological, morphological and growth responses of the dominant grass species from each of the four major grasslands of the central U.S. (ranging from tallgrass prairie to desert grassland) following severe drought. Despite significant differences in baseline values, full recovery in leaf physiological function was evident across species, of which was consistently driven by the production of new leaves. Further, recovery in whole-plant carbon uptake tended to be driven by shifts in allocation from belowground to aboveground structures. However, there was clear variability among species in the magnitude of this dynamic as well as the relative allocation to stem versus leaf production. As a result, all species harbored the physiological capacity to recover from drought, yet we posit that variability in the recovery of whole-plant carbon uptake to be more strongly driven by variability in the sensitivity of species' morphology to soil moisture increases. The next step of this project will be to incorporate these and other existing data on these species and ecosystems into the community land model in an effort to test the sensitivity of this model to these data.

  2. An approach to modeling and optimization of integrated renewable energy system (ires)

    Science.gov (United States)

    Maheshwari, Zeel

    The purpose of this study was to cost optimize electrical part of IRES (Integrated Renewable Energy Systems) using HOMER and maximize the utilization of resources using MATLAB programming. IRES is an effective and a viable strategy that can be employed to harness renewable energy resources to energize remote rural areas of developing countries. The resource- need matching, which is the basis for IRES makes it possible to provide energy in an efficient and cost effective manner. Modeling and optimization of IRES for a selected study area makes IRES more advantageous when compared to hybrid concepts. A remote rural area with a population of 700 in 120 households and 450 cattle is considered as an example for cost analysis and optimization. Mathematical models for key components of IRES such as biogas generator, hydropower generator, wind turbine, PV system and battery banks are developed. A discussion of the size of water reservoir required is also presented. Modeling of IRES on the basis of need to resource and resource to need matching is pursued to help in optimum use of resources for the needs. Fixed resources such as biogas and water are used in prioritized order whereas movable resources such as wind and solar can be used simultaneously for different priorities. IRES is cost optimized for electricity demand using HOMER software that is developed by the NREL (National Renewable Energy Laboratory). HOMER optimizes configuration for electrical demand only and does not consider other demands such as biogas for cooking and water for domestic and irrigation purposes. Hence an optimization program based on the need-resource modeling of IRES is performed in MATLAB. Optimization of the utilization of resources for several needs is performed. Results obtained from MATLAB clearly show that the available resources can fulfill the demand of the rural areas. Introduction of IRES in rural communities has many socio-economic implications. It brings about improvement in living

  3. Reducing software security risk through an integrated approach research initiative model based verification of the Secure Socket Layer (SSL) Protocol

    Science.gov (United States)

    Powell, John D.

    2003-01-01

    This document discusses the verification of the Secure Socket Layer (SSL) communication protocol as a demonstration of the Model Based Verification (MBV) portion of the verification instrument set being developed under the Reducing Software Security Risk (RSSR) Trough an Integrated Approach research initiative. Code Q of the National Aeronautics and Space Administration (NASA) funds this project. The NASA Goddard Independent Verification and Validation (IV&V) facility manages this research program at the NASA agency level and the Assurance Technology Program Office (ATPO) manages the research locally at the Jet Propulsion Laboratory (California institute of Technology) where the research is being carried out.

  4. Pipeline integrity model-a formative approach towards reliability and life assessment

    International Nuclear Information System (INIS)

    Sayed, A.M.; Jaffery, M.A.

    2005-01-01

    Pipe forms an integral part of transmission medium in oil and gas industry. This holds true for both upstream and downstream segments of this global energy business. With the aging of this asset base, emphasis on its operational aspects has been under immense considerations from the operators and regulators sides. Moreover, the milieu of information area and enhancement in global trade has lifted the barriers on means to forge forward towards better utilization of resources. This has resulted in optimized solutions as priority for business and technical manager's world over. There is a paradigm shift from mere development of 'smart materials' to 'low life cycle cost material'. The force inducing this change is a rationale one: the recovery of development costs is no more a problem in a global community; rather it is the pay-off time which matters most to the materials end users. This means that decision makers are not evaluating just the price offered but are keen to judge the entire life cycle cost of a product. The integrity of pipe are affected by factors such as corrosion, fatigue-crack growth, stress-corrosion cracking, and mechanical damage. Extensive research in the area of reliability and life assessment has been carried out. A number of models concerning with the reliability issues of pipes have been developed and are being used by a number of pipeline operators worldwide. Yet, it is emphasised that there are no substitute for sound engineering judgment and allowance for factors of safety. The ability of a laid down pipe network to transport the intended fluid under pre-defined conditions for the entire project envisaged life, is referred to the reliability of system. The reliability is built into the product through extensive benchmarking against industry standard codes. The process of pipes construction for oil and gas service is regulated through American Petroleum Institute's Specification for Line Pipe. Subsequently, specific programs have been

  5. Virtue Existential Career Model: A Dialectic and Integrative Approach Echoing Eastern Philosophy

    Directory of Open Access Journals (Sweden)

    Shu-Hui Liu

    2016-11-01

    Full Text Available Our Virtue Existential Career (VEC model aims at complementing western modernism and postmodernism career theories with eastern philosophy. With dialectical philosophy and virtue-practice derived from the Classic of Changes, our VEC theoretical foundation incorporates merits from Holland typology, Minnesota Theory of Work Adjustment, Social Cognitive Career Theory, Meaning Therapy, Narrative Approach Career Counseling, and Happenstance Learning Theory. While modernism considers a matched job as an ideal career vision and prefers rational strategies (controlling and realizing to achieve job security; postmodernism prefers adapting and appreciating strategies toward openness and appreciates multiple possible selves and occupations, our VEC model pursues a blending of security and openness via controlling-and-realizing and appreciating-and-adapting interwoven with each other in a dialectical and harmonious way. Our VEC counseling prototype aims at a secular goal of living on the earth with ways and harmony (安身以法以和 and an ultimate end to spiral up to the wisdom of living up to the way of heaven (天道 with mind and virtue (立命以心以德. A VEC counseling process of five major career strategies, metaphorical stories of qian and kun, and experiential activities are developed to deliver VEC concepts. The VEC model and prototype presented in this research is the product of an action research following Lewin’s (1946 top-to-down model. Situated structure analyses were conducted to further investigate the adequacy of this version of VEC model and prototype. Data from two groups (one for stranded college graduates and the other for growing college students revealed empirical supports. Yang type of career praxes tend to induce actualization, which resulting in realistic goals and concrete action plans; yin type of career praxes tend to increase self-efficacy, which resulting in positive attitude toward current situatedness and future

  6. Virtue Existential Career Model: A Dialectic and Integrative Approach Echoing Eastern Philosophy

    Science.gov (United States)

    Liu, Shu-Hui; Hung, Jui-Ping; Peng, Hsin-I; Chang, Chia-Hui; Lu, Yi-Jen

    2016-01-01

    Our Virtue Existential Career (VEC) model aims at complementing western modernism and postmodernism career theories with eastern philosophy. With dialectical philosophy and virtue-practice derived from the Classic of Changes, the VEC theoretical foundation incorporates merits from Holland typology, Minnesota Theory of Work Adjustment, Social Cognitive Career Theory, Meaning Therapy, Narrative Approach Career Counseling, and Happenstance Learning Theory. While modernism considers a matched job as an ideal career vision and prefers rational strategies (controlling and realizing) to achieve job security; postmodernism prefers appreciating and adapting strategies toward openness and appreciates multiple possible selves and occupations, our model pursues a blending of security and openness via controlling-and-realizing and appreciating-and-adapting interwoven with each other in a dialectical and harmonious way. Our VEC counseling prototype aims at a secular goal of living on the earth with ways and harmony (安身以法以和) and an ultimate end to spiral up to the wisdom of living up to the way of heaven (天道) with mind and virtue (立命以心以德). A VEC counseling process of five major career strategies, metaphorical stories of qian and kun, and experiential activities are developed to deliver VEC concepts. The VEC model and prototype presented in this research is the product of an action research following Lewin's (1946) top-to-down model. Situated structure analyses were conducted to further investigate the adequacy of this version of VEC model and prototype. Data from two groups (one for stranded college graduates and the other for growing college students) revealed empirical supports. Yang type of career praxes tends to induce actualization, which resulting in realistic goals and concrete action plans; yin type of career praxes tends to increase self-efficacy, which resulting in positive attitude toward current situatedness and future development

  7. Virtue Existential Career Model: A Dialectic and Integrative Approach Echoing Eastern Philosophy.

    Science.gov (United States)

    Liu, Shu-Hui; Hung, Jui-Ping; Peng, Hsin-I; Chang, Chia-Hui; Lu, Yi-Jen

    2016-01-01

    Our Virtue Existential Career (VEC) model aims at complementing western modernism and postmodernism career theories with eastern philosophy. With dialectical philosophy and virtue-practice derived from the Classic of Changes , the VEC theoretical foundation incorporates merits from Holland typology, Minnesota Theory of Work Adjustment, Social Cognitive Career Theory, Meaning Therapy, Narrative Approach Career Counseling, and Happenstance Learning Theory. While modernism considers a matched job as an ideal career vision and prefers rational strategies ( controlling and realizing ) to achieve job security; postmodernism prefers appreciating and adapting strategies toward openness and appreciates multiple possible selves and occupations, our model pursues a blending of security and openness via controlling-and-realizing and appreciating-and-adapting interwoven with each other in a dialectical and harmonious way. Our VEC counseling prototype aims at a secular goal of living on the earth with ways and harmony () and an ultimate end to spiral up to the wisdom of living up to the way of heaven () with mind and virtue (). A VEC counseling process of five major career strategies, metaphorical stories of qian and kun , and experiential activities are developed to deliver VEC concepts. The VEC model and prototype presented in this research is the product of an action research following Lewin's (1946) top-to-down model. Situated structure analyses were conducted to further investigate the adequacy of this version of VEC model and prototype. Data from two groups (one for stranded college graduates and the other for growing college students) revealed empirical supports. Y ang type of career praxes tends to induce actualization, which resulting in realistic goals and concrete action plans; yin type of career praxes tends to increase self-efficacy, which resulting in positive attitude toward current situatedness and future development. Acceptance and dialectic thinking often

  8. Mechatronics an integrated approach

    CERN Document Server

    de Silva, Clarence W

    2004-01-01

    Table of MECHATRONIC ENGINEERINGMechatronic SystemsStudy of MechatronicsReferences and Further ReadingDYNAMIC MODELS AND ANALOGIESTerminologyAnalogiesState-Space Representation Model Linearization Linear GraphsState Models From Linear GraphsElectrical SystemsFluid SystemsThermal SystemsBond GraphsTransfer-Function ModelsFrequency Domain ModelsResponse Analysis And SimulationMECHANICAL COMPONENTS AND ROBOTIC MANIPULATORSMechanical ComponentsTransmission ComponentsRobotic ManipulatorsRobotic GrippersCOMPONENT INTERCONNECTION AND SIGNAL CONDITIONINGComponent InterconnectionImpedance Characteristi

  9. Integrating computer-aided modeling and micro-simulation in multi-criteria evaluation of service infrastructure assignment approaches

    Directory of Open Access Journals (Sweden)

    Alfonso Duran

    2013-07-01

    Full Text Available Purpose: This paper proposes an integrated computer-supported multi-staged approach to the flexible design and multicriteria evaluation of service infrastructure assignment processes/ algorithms. Design/methodology/approach: It involves particularizing a metamodel encompassing the main generic components and relationships into process models and process instances, by incorporating structural data from the real-life system. Existing data on the target user population is fed into a micro-modeling system to generate a matching population of individual “virtual” users, each with its own set of trait values. The micro-simulation of their interaction with the assignment process of both the incumbent and the competitors generates a rich multi-dimensional output, encompassing both “revealed” and non-observable data. This enables a comprehensive multi-criteria evaluation of the foreseeable performance of the designed process/ algorithm, and therefore its iterative improvement. Findings: The research project developed a set of methodologies and associated supporting tools encompassing the modeling, micro-simulation and performance assessment of service infrastructure assignment processes. Originality/value: The proposed approach facilitates, in a multicriteria environment, the flexible modeling/design of situation-specific assignment processes/algorithms and their performance assessment when facing their case-specific user population.

  10. Earthworms Dilong: Ancient, Inexpensive, Noncontroversial Models May Help Clarify Approaches to Integrated Medicine Emphasizing Neuroimmune Systems

    Science.gov (United States)

    Cooper, Edwin L.; Balamurugan, Mariappan; Huang, Chih-Yang; Tsao, Clara R.; Heredia, Jesus; Tommaseo-Ponzetta, Mila; Paoletti, Maurizio G.

    2012-01-01

    Earthworms have provided ancient cultures with food and sources of medicinal cures. Ayurveda, traditional Chinese medicine (TCM), and practices in Japan, Vietnam, and Korea have focused first on earthworms as sources of food. Gradually fostering an approach to potential beneficial healing properties, there are renewed efforts through bioprospecting and evidence-based research to understand by means of rigorous investigations the mechanisms of action whether earthworms are used as food and/or as sources of potential medicinal products. Focusing on earthworms grew by serendipity from an extensive analysis of the earthworm's innate immune system. Their immune systems are replete with leukocytes and humoral products that exert credible health benefits. Their emerging functions with respect to evolution of innate immunity have long been superseded by their well-known ecological role in soil conservation. Earthworms as inexpensive, noncontroversial animal models (without ethical concerns) are not vectors of disease do not harbor parasites that threaten humans nor are they annoying pests. By recognizing their numerous ecological, environmental, and biomedical roles, substantiated by inexpensive and more comprehensive investigations, we will become more aware of their undiscovered beneficial properties. PMID:22888362

  11. Integrative approaches: promoting socioecological resilience

    Science.gov (United States)

    J.W. Long; Carl Skinner; M. North; C.T. Hunsaker; L. Quinn-Davidson

    2014-01-01

    This chapter begins by discussing current challenges for ecosystem management that emerged from multiple chapters of the full synthesis. It then considers integrative approaches to promote resilience, including general strategies that recognize the integrated nature of socioecological systems, the importance of promoting disturbance regimes upon which these systems...

  12. Integrative approaches for modeling regulation and function of the respiratory system.

    Science.gov (United States)

    Ben-Tal, Alona; Tawhai, Merryn H

    2013-01-01

    Mathematical models have been central to understanding the interaction between neural control and breathing. Models of the entire respiratory system-which comprises the lungs and the neural circuitry that controls their ventilation-have been derived using simplifying assumptions to compartmentalize each component of the system and to define the interactions between components. These full system models often rely-through necessity-on empirically derived relationships or parameters, in addition to physiological values. In parallel with the development of whole respiratory system models are mathematical models that focus on furthering a detailed understanding of the neural control network, or of the several functions that contribute to gas exchange within the lung. These models are biophysically based, and rely on physiological parameters. They include single-unit models for a breathing lung or neural circuit, through to spatially distributed models of ventilation and perfusion, or multicircuit models for neural control. The challenge is to bring together these more recent advances in models of neural control with models of lung function, into a full simulation for the respiratory system that builds upon the more detailed models but remains computationally tractable. This requires first understanding the mathematical models that have been developed for the respiratory system at different levels, and which could be used to study how physiological levels of O2 and CO2 in the blood are maintained. Copyright © 2013 Wiley Periodicals, Inc.

  13. Innovation in Integrated Chemical Product-Process Design - Development through a Model-based Systems Approach

    DEFF Research Database (Denmark)

    Conte, Elisa

    in which experiments are planned and a third stage in which experiments are performed to validate the final product formula. The main focus of the project is on the development of the computer-aided stage of the methodology described above. The methodology considers two different scenarios: the design...... appropriate model-based screening techniques are employed. In the verification scenario, a shortlist of candidate ingredients is provided, therefore the problem size is much smaller and rigorous property models can be employed/developed. When using computer-aided tools for product design, several issues need...... to be addressed: new property models may need to be developed and/or the application range of existing property models may need to be extended (that is, new model parameters are needed), new and more efficient methods and tools for the application of the models may need to be developed, together with a flexible...

  14. Thermal management optimization of a thermoelectric-integrated methanol evaporator using a compact CFD modeling approach

    DEFF Research Database (Denmark)

    Xin, Gao; Chen, Min; Snyder, G. Jeffrey

    2013-01-01

    To better manage the magnitude and the direction of the heat flux in an exchanger-based methanol evaporator of a fuel cell system, thermoelectric (TE) modules can be deployed as TE heat flux regulators (TERs). The performance of the TE-integrated evaporator is strongly influenced by its heat......, and uses a different material property acquisition method based on module manufacturers’ datasheets. Secondly, a simulation study is carried out on the novel evaporator to minimize its thermal resistance and to assess the evaporator pressure drop. The factors studied include: type of the fins of the heat...

  15. Integrated assessment of policy interventions for promoting sustainable irrigation in semi-arid environments: a hydro-economic modeling approach.

    Science.gov (United States)

    Blanco-Gutiérrez, Irene; Varela-Ortega, Consuelo; Purkey, David R

    2013-10-15

    Sustaining irrigated agriculture to meet food production needs while maintaining aquatic ecosystems is at the heart of many policy debates in various parts of the world, especially in arid and semi-arid areas. Researchers and practitioners are increasingly calling for integrated approaches, and policy-makers are progressively supporting the inclusion of ecological and social aspects in water management programs. This paper contributes to this policy debate by providing an integrated economic-hydrologic modeling framework that captures the socio-economic and environmental effects of various policy initiatives and climate variability. This modeling integration includes a risk-based economic optimization model and a hydrologic water management simulation model that have been specified for the Middle Guadiana basin, a vulnerable drought-prone agro-ecological area with highly regulated river systems in southwest Spain. Namely, two key water policy interventions were investigated: the implementation of minimum environmental flows (supported by the European Water Framework Directive, EU WFD), and a reduction in the legal amount of water delivered for irrigation (planned measure included in the new Guadiana River Basin Management Plan, GRBMP, still under discussion). Results indicate that current patterns of excessive water use for irrigation in the basin may put environmental flow demands at risk, jeopardizing the WFD's goal of restoring the 'good ecological status' of water bodies by 2015. Conflicts between environmental and agricultural water uses will be stressed during prolonged dry episodes, and particularly in summer low-flow periods, when there is an important increase of crop irrigation water requirements. Securing minimum stream flows would entail a substantial reduction in irrigation water use for rice cultivation, which might affect the profitability and economic viability of small rice-growing farms located upstream in the river. The new GRBMP could contribute

  16. Optimization of soil hydraulic model parameters using Synthetic Aperture Radar data: an integrated multidisciplinary approach

    Science.gov (United States)

    Mattia, F.; Pauwels, V. R.; Balenzano, A.; Satalino, G.; Skriver, H.; Verhoest, N. E.

    2008-12-01

    It is widely recognized that Synthetic Aperture Radar (SAR) data are a very valuable source of information for the modeling of the interactions between the land surface and the atmosphere. During the last couple of decades, most of the research on the use of SAR data in hydrologic applications has been focused on the retrieval of land and bio-geophysical parameters (e.g. soil moisture contents). One relatively unexplored issue consists of the optimization of soil hydraulic model parameters, such as for example hydraulic conductivity values, through remote sensing. This is due to the fact that no direct relationships between the remote sensing observations, more specifically radar backscatter values, and the parameter values can be derived. However, land surface models can provide these relationships. The objective of this study is to retrieve a number of soil physical model parameters through a combination of remote sensing and land surface modeling. Spatially distributed and multitemporal SAR-based soil moisture maps are the basis of the study. The surface soil moisture values are used in a parameter estimation procedure based on the Extended Kalman Filter equations. In fact, the land surface model is thus used to determine the relationship between the soil physical parameters and the remote sensing data. An analysis is then performed, relating the retrieved soil parameters to the soil texture data available over the study area. The results of the study show that there is a potential to retrieve soil physical model parameters through a combination of land surface modeling and remote sensing.

  17. An Integrated Approach Based on Numerical Modelling and Geophysical Survey to Map Groundwater Salinity in Fractured Coastal Aquifers

    Directory of Open Access Journals (Sweden)

    Costantino Masciopinto

    2017-11-01

    Full Text Available Aquifer over-exploitation may increase coastal seawater intrusion by reducing freshwater availability. Fractured subsurface formations commonly host important freshwater reservoirs along sea coasts. These water resources are particularly vulnerable to the contamination due to seawater infiltration occurring through rapid pathways via fractures. Modeling of density driven fluid flow in fractured aquifers is complex, as their hydrodynamics are controlled by interactions between preferential flow pathways, 3D interconnected fractures and rock-matrix porosity distribution. Moreover, physical heterogeneities produce highly localized water infiltrations that make the modeling of saltwater transport in such aquifers very challenging. The new approach described in this work provides a reliable hydrogeological model suitable to reproduce local advancements of the freshwater/saltwater wedge in coastal aquifers. The proposed model use flow simulation results to estimate water salinities in groundwater at a specific depth (1 m below water table by means of positions of the Ghyben-Herzberg saltwater/freshwater sharp interface along the coast. Measurements of salinity in 25 boreholes (i.e., salinity profiles have been used for the model calibration. The results provide the groundwater salinity map in freshwater/saltwater transition coastal zones of the Bari (Southern Italy fractured aquifer. Non-invasive geophysical measurements in groundwater, particularly into vertical 2D vertical cross-sections, were carried out by using the electrical resistivity tomography (ERT in order to validate the model results. The presented integrated approach is very easy to apply and gives very realistic salinity maps in heterogeneous aquifers, without simulating density driven water flow in fractures.

  18. Integration of kinetic modeling and desirability function approach for multi-objective optimization of UASB reactor treating poultry manure wastewater.

    Science.gov (United States)

    Yetilmezsoy, Kaan

    2012-08-01

    An integrated multi-objective optimization approach within the framework of nonlinear regression-based kinetic modeling and desirability function was proposed to optimize an up-flow anaerobic sludge blanket (UASB) reactor treating poultry manure wastewater (PMW). Chen-Hashimoto and modified Stover-Kincannon models were applied to the UASB reactor for determination of bio-kinetic coefficients. A new empirical formulation of volumetric organic loading rate was derived for the first time for PMW to estimate the dimensionless kinetic parameter (K) in the Chen-Hashimoto model. Maximum substrate utilization rate constant and saturation constant were predicted as 11.83 g COD/L/day and 13.02 g COD/L/day, respectively, for the modified Stover-Kincannon model. Based on four process-related variables, three objective functions including a detailed bio-economic model were derived and optimized by using a LOQO/AMPL algorithm, with a maximum overall desirability of 0.896. The proposed optimization scheme demonstrated a useful tool for the UASB reactor to optimize several responses simultaneously. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. The multiple convolution integral approach to uncertainty analysis in fate and transport models used in risk assessment

    Science.gov (United States)

    Dawoud, Emran A.

    Probabilistic risk estimates are typically not obtained for time-dependent releases of radioactive contaminants to the geosphere when a series of sequentially coupled transport models are required for determining results. This is due, in part, to the geophysical complexity of the site, numerical complexity of the fate and transport models, and a lack of a practical tool for linking the transport components in a fashion that facilitates uncertainty analysis. Using the theory of convolution integration, sequentially coupled submodels can be replaced with an independent system of impulse responses for each submodel. Uncertainties are then propagated independently through each of the submodels to significantly reduce the complexity of the calculations and computational time. The impulse responses of the submodels are then convolved to obtain a final result that is equivalent to the sequentially coupled estimates for each source distribution of interest. In this research a multiple convolution integral (MCI) approach is developed and the decoupling of fate and transport processes into an independent system is described. A conceptual model, extracted from the Inactive Tanks project at the Oak Ridge National Laboratory (ORNL), is used to demonstrate the approach. In this application, uncertainties in the final risk estimates resulting from the ingestion of surface water show that the range of variations of the right tail of the PDFs are over several order of magnitude. Also, sensitivity analysis shows that uncertainty in the final risk is mainly attributed to uncertainties inherent in the parameter values of the transport model and exposure duration. These results demonstrate that while the variation in the tail of time-dependent risk PDF (the region of interest to regulatory decisions) are large, the resulting confidence level that human health has been protected is only slightly increased. In terms of remediation cost, this slight increase yields huge costs, and might

  20. Building and integrating reliability models in a Reliability-Centered-Maintenance approach

    International Nuclear Information System (INIS)

    Verite, B.; Villain, B.; Venturini, V.; Hugonnard, S.; Bryla, P.

    1998-03-01

    Electricite de France (EDF) has recently developed its OMF-Structures method, designed to optimize preventive maintenance of passive structures such as pipes and support, based on risk. In particular, reliability performances of components need to be determined; it is a two-step process, consisting of a qualitative sort followed by a quantitative evaluation, involving two types of models. Initially, degradation models are widely used to exclude some components from the field of preventive maintenance. The reliability of the remaining components is then evaluated by means of quantitative reliability models. The results are then included in a risk indicator that is used to directly optimize preventive maintenance tasks. (author)

  1. Optimization of Soil Hydraulic Model Parameters Using Synthetic Aperture Radar Data: An Integrated Multidisciplinary Approach

    DEFF Research Database (Denmark)

    Pauwels, Valentijn; Balenzano, Anna; Satalino, Giuseppe

    2009-01-01

    that no direct relationships between the remote-sensing observations, more specifically radar backscatter values, and the parameter values can be derived. However, land surface models can provide these relationships. The objective of this paper is to retrieve a number of soil physical model parameters through...... model is, thus, used to determine the relationship between the soil physical parameters and the remote-sensing data. An analysis is then performed, relating the retrieved soil parameters to the soil texture data available over the study area. The results of the study show that there is a potential...

  2. Developing Dynamic Reference Models and a Decision Support Framework for Southeastern Ecosystems: An Integrated Approach

    Science.gov (United States)

    2015-06-01

    this approach because it has been frequently reported that dry combustion process results in higher C values than chemical oxidation with the... combustion processes have also resulted in higher N values than the Kjeldahl method (Pereira et al. 2006; Dieckow et al. 2007). Thus, considering this...UK. Creech, M. N., L. K. Kirkman, and L. A. Morris. 2012. Alteration and recovery of slash pile burn sites in the restoration of a fire

  3. Integrated urban systems modeling : designing a seamless, comprehensive approach to transportation planning.

    Science.gov (United States)

    2009-01-01

    Metropolitan planning agencies face increasingly complex issues in modeling interactions between the built environment and multimodal transportation systems. Although great strides have been made in simulating land use, travel demand, and traffic flo...

  4. Assessment of source-receptor relationships of aerosols: An integrated forward and backward modeling approach

    Science.gov (United States)

    Kulkarni, Sarika

    This dissertation presents a scientific framework that facilitates enhanced understanding of aerosol source -- receptor (S/R) relationships and their impact on the local, regional and global air quality by employing a complementary suite of modeling methods. The receptor -- oriented Positive Matrix Factorization (PMF) technique is combined with Potential Source Contribution Function (PSCF), a trajectory ensemble model, to characterize sources influencing the aerosols measured at Gosan, Korea during spring 2001. It is found that the episodic dust events originating from desert regions in East Asia (EA) that mix with pollution along the transit path, have a significant and pervasive impact on the air quality of Gosan. The intercontinental and hemispheric transport of aerosols is analyzed by a series of emission perturbation simulations with the Sulfur Transport and dEposition Model (STEM), a regional scale Chemical Transport Model (CTM), evaluated with observations from the 2008 NASA ARCTAS field campaign. This modeling study shows that pollution transport from regions outside North America (NA) contributed ˜ 30 and 20% to NA sulfate and BC surface concentration. This study also identifies aerosols transported from Europe, NA and EA regions as significant contributors to springtime Arctic sulfate and BC. Trajectory ensemble models are combined with source region tagged tracer model output to identify the source regions and possible instances of quasi-lagrangian sampled air masses during the 2006 NASA INTEX-B field campaign. The impact of specific emission sectors from Asia during the INTEX-B period is studied with the STEM model, identifying residential sector as potential target for emission reduction to combat global warming. The output from the STEM model constrained with satellite derived aerosol optical depth and ground based measurements of single scattering albedo via an optimal interpolation assimilation scheme is combined with the PMF technique to

  5. An iterative and integrative approach to modeling the morphological alterations in backwater condition: A case study of Darby Creek, PA

    Science.gov (United States)

    Hosseiny, S. M. H.; Smith, V.

    2017-12-01

    Darby Creek is an urbanized highly flood-prone watershed in Metro-Philadelphia, PA. The floodplain and the main channel are composed of alluvial sediment and are subject to frequent geomorphological changes. The lower part of the channel is within the coastal zone, subjugating the flow to a backwater condition. This study applies a multi-disciplinary approach to modeling the morphological alteration of the creek and floodplain in presence of the backwater using an iteration and integration of combined models. To do this, FaSTMECH (a two-dimensional quasi unsteady flow solver) in International River Interface Cooperative software (iRIC) is coupled with a 1-dimensional backwater model to calculate hydraulic characteristics of the flow over a digital elevation model of the channel and floodplain. One USGS gage at the upstream and two NOAA gages at the downstream are used for model validation. The output of the model is afterward used to calculate sediment transport and morphological changes over the domain through time using an iterative process. The updated elevation data is incorporated in the hydraulic model again to calculate the velocity field. The calculations continue reciprocally over discrete discharges of the hydrograph until the flood attenuates and the next flood event occurs. The results from this study demonstrate how to incorporate bathymetry and flow data to model floodplain evolution in the backwater through time, and provide a means to better understanding the dynamics of the floodplain. This work is not only applicable to river management, but also provides insight to the geoscience community concerning the development of landscapes in the backwater.

  6. Evaluation Of The Integrated Solubility Model, A Graded Approach For Predicting Phase Distribution In Hanford Tank Waste

    International Nuclear Information System (INIS)

    Pierson, Kayla L.; Belsher, Jeremy D.; Seniow, Kendra R.

    2012-01-01

    The mission of the DOE River Protection Project (RPP) is to store, retrieve, treat and dispose of Hanford's tank waste. Waste is retrieved from the underground tanks and delivered to the Waste Treatment and Immobilization Plant (WTP). Waste is processed through a pretreatment facility where it is separated into low activity waste (LAW), which is primarily liquid, and high level waste (HLW), which is primarily solid. The LAW and HLW are sent to two different vitrification facilities and glass canisters are then disposed of onsite (for LAW) or shipped off-site (for HLW). The RPP mission is modeled by the Hanford Tank Waste Operations Simulator (HTWOS), a dynamic flowsheet simulator and mass balance model that is used for mission analysis and strategic planning. The integrated solubility model (ISM) was developed to improve the chemistry basis in HTWOS and better predict the outcome of the RPP mission. The ISM uses a graded approach to focus on the components that have the greatest impact to the mission while building the infrastructure for continued future improvement and expansion. Components in the ISM are grouped depending upon their relative solubility and impact to the RPP mission. The solubility of each group of components is characterized by sub-models of varying levels of complexity, ranging from simplified correlations to a set of Pitzer equations used for the minimization of Gibbs Energy

  7. Repurposing and probabilistic integration of data: An iterative and data model independent approach

    NARCIS (Netherlands)

    Wanders, B.

    2016-01-01

    Besides the scientific paradigms of empiricism, mathematical modelling, and simulation, the method of combining and analysing data in novel ways has become a main research paradigm capable of tackling research questions that could not be answered before. To speed up research in this new paradigm,

  8. Improving the Efficiency of Medical Services Systems: A New Integrated Mathematical Modeling Approach

    Directory of Open Access Journals (Sweden)

    Davood Shishebori

    2013-01-01

    Full Text Available Nowadays, the efficient design of medical service systems plays a critical role in improving the performance and efficiency of medical services provided by governments. Accordingly, health care planners in countries especially with a system based on a National Health Service (NHS try to make decisions on where to locate and how to organize medical services regarding several conditions in different residence areas, so as to improve the geographic equity of comfortable access in the delivery of medical services while accounting for efficiency and cost issues especially in crucial situations. Therefore, optimally locating of such services and also suitable allocating demands them, can help to enhance the performance and responsiveness of medical services system. In this paper, a multiobjective mixed integer nonlinear programming model is proposed to decide locations of new medical system centers, link roads that should be constructed or improved, and also urban residence centers covered by these medical service centers and link roads under investment budget constraint in order to both minimize the total transportation cost of the overall system and minimize the total failure cost (i.e., maximize the system reliability of medical service centers under unforeseen situations. Then, the proposed model is linearized by suitable techniques. Moreover, a practical case study is presented in detail to illustrate the application of the proposed mathematical model. Finally, a sensitivity analysis is done to provide an insight into the behavior of the proposed model in response to changes of key parameters of the problem.

  9. Modeling international stock market contagion using multivariate fractionally integrated APARCH approach

    Directory of Open Access Journals (Sweden)

    Zouheir Mighri

    2014-12-01

    Full Text Available The aim of this article is to examine how the dynamics of correlations between two emerging countries (Brazil and Mexico and the US evolved from January 2003 to December 2013. The main contribution of this study is to explore whether the plunging stock market in the US, in the aftermath of global financial crisis (2007–2009, exerts contagion effects on emerging stock markets. To this end, we rely on a multivariate fractionally integrated asymmetric power autoregressive conditional heteroskedasticity dynamic conditional correlation framework, which accounts for long memory, power effects, leverage terms, and time-varying correlations. The empirical analysis shows a contagion effect for Brazil and Mexico during the early stages of the global financial crisis, indicating signs of “recoupling.” Nevertheless, linkages show a general pattern of “decoupling” after the Lehman Brothers collapse. Furthermore, correlations between Brazil and the US are decreased from early 2009 onwards, implying that their dependence is larger in bearish than in bullish markets.

  10. Climate change impact assessment on Veneto and Friuli plain groundwater. Part I: An integrated modeling approach for hazard scenario construction

    International Nuclear Information System (INIS)

    Baruffi, F.; Cisotto, A.; Cimolino, A.; Ferri, M.; Monego, M.; Norbiato, D.; Cappelletto, M.; Bisaglia, M.; Pretner, A.; Galli, A.; Scarinci, A.; Marsala, V.; Panelli, C.; Gualdi, S.; Bucchignani, E.; Torresan, S.; Pasini, S.; Critto, A.

    2012-01-01

    Climate change impacts on water resources, particularly groundwater, is a highly debated topic worldwide, triggering international attention and interest from both researchers and policy makers due to its relevant link with European water policy directives (e.g. 2000/60/EC and 2007/118/EC) and related environmental objectives. The understanding of long-term impacts of climate variability and change is therefore a key challenge in order to address effective protection measures and to implement sustainable management of water resources. This paper presents the modeling approach adopted within the Life + project TRUST (Tool for Regional-scale assessment of groUndwater Storage improvement in adaptation to climaTe change) in order to provide climate change hazard scenarios for the shallow groundwater of high Veneto and Friuli Plain, Northern Italy. Given the aim to evaluate potential impacts on water quantity and quality (e.g. groundwater level variation, decrease of water availability for irrigation, variations of nitrate infiltration processes), the modeling approach integrated an ensemble of climate, hydrologic and hydrogeologic models running from the global to the regional scale. Global and regional climate models and downscaling techniques were used to make climate simulations for the reference period 1961–1990 and the projection period 2010–2100. The simulation of the recent climate was performed using observed radiative forcings, whereas the projections have been done prescribing the radiative forcings according to the IPCC A1B emission scenario. The climate simulations and the downscaling, then, provided the precipitation, temperatures and evapo-transpiration fields used for the impact analysis. Based on downscaled climate projections, 3 reference scenarios for the period 2071–2100 (i.e. the driest, the wettest and the mild year) were selected and used to run a regional geomorphoclimatic and hydrogeological model. The final output of the model ensemble

  11. Integrating Occupational Characteristics into Human Performance Models: IPME Versus ISMAT Approach

    Science.gov (United States)

    2009-08-01

    cognitive and physical abilities of a soldier. 2. Manpower: the number of personnel required to operate, maintain, sustain, and provide training for...equipment model in IPME to address such design questions as maintenance requirements. Conventional performance measures (e.g., cognitive workload) can also...from the Halifax. Contact 2 is identified as the Dolphin from Miami, Florida. It is fishing legally. VTUAV 1 turns towards Contact 3 and level

  12. Generator Approach to Evolutionary Optimization of Catalysts and its Integration with Surrogate Modeling

    Czech Academy of Sciences Publication Activity Database

    Holeňa, Martin; Linke, D.; Rodemerck, U.

    2011-01-01

    Roč. 159, č. 1 (2011), s. 84-95 ISSN 0920-5861 R&D Projects: GA ČR GA201/08/0802 Institutional research plan: CEZ:AV0Z10300504 Keywords : optimization of catalytic materials * evolutionary optimization * surrogate modeling * artificial neural networks * multilayer perceptron * regression boosting Subject RIV: IN - Informatics, Computer Science Impact factor: 3.407, year: 2011

  13. Impacts of climate change on farm income security in Central Asia: An integrated modeling approach

    OpenAIRE

    Bobojonov, Ihtiyor; Aw-Hassan, Aden

    2014-01-01

    Increased risk due to global warming has already become embedded in agricultural decision making in Central Asia and uncertainties are projected to increase even further. Agro-ecology and economies of Central Asia are heterogenous and very little is known about the impact of climate change at the sub-national levels. The bio-economic farm model (BEFM) is used for ex ante assessment of climate change impacts at sub-national levels in Central Asia. The BEFM is calibrated to 10 farming systems i...

  14. An integrative approach for modeling and simulation of heterocyst pattern formation in cyanobacteria filaments.

    Directory of Open Access Journals (Sweden)

    Alejandro Torres-Sánchez

    2015-03-01

    Full Text Available Heterocyst differentiation in cyanobacteria filaments is one of the simplest examples of cellular differentiation and pattern formation in multicellular organisms. Despite of the many experimental studies addressing the evolution and sustainment of heterocyst patterns and the knowledge of the genetic circuit underlying the behavior of single cyanobacterium under nitrogen deprivation, there is still a theoretical gap connecting these two macroscopic and microscopic processes. As an attempt to shed light on this issue, here we explore heterocyst differentiation under the paradigm of systems biology. This framework allows us to formulate the essential dynamical ingredients of the genetic circuit of a single cyanobacterium into a set of differential equations describing the time evolution of the concentrations of the relevant molecular products. As a result, we are able to study the behavior of a single cyanobacterium under different external conditions, emulating nitrogen deprivation, and simulate the dynamics of cyanobacteria filaments by coupling their respective genetic circuits via molecular diffusion. These two ingredients allow us to understand the principles by which heterocyst patterns can be generated and sustained. In particular, our results point out that, by including both diffusion and noisy external conditions in the computational model, it is possible to reproduce the main features of the formation and sustainment of heterocyst patterns in cyanobacteria filaments as observed experimentally. Finally, we discuss the validity and possible improvements of the model.

  15. An integrative approach for modeling and simulation of heterocyst pattern formation in cyanobacteria filaments.

    Science.gov (United States)

    Torres-Sánchez, Alejandro; Gómez-Gardeñes, Jesús; Falo, Fernando

    2015-03-01

    Heterocyst differentiation in cyanobacteria filaments is one of the simplest examples of cellular differentiation and pattern formation in multicellular organisms. Despite of the many experimental studies addressing the evolution and sustainment of heterocyst patterns and the knowledge of the genetic circuit underlying the behavior of single cyanobacterium under nitrogen deprivation, there is still a theoretical gap connecting these two macroscopic and microscopic processes. As an attempt to shed light on this issue, here we explore heterocyst differentiation under the paradigm of systems biology. This framework allows us to formulate the essential dynamical ingredients of the genetic circuit of a single cyanobacterium into a set of differential equations describing the time evolution of the concentrations of the relevant molecular products. As a result, we are able to study the behavior of a single cyanobacterium under different external conditions, emulating nitrogen deprivation, and simulate the dynamics of cyanobacteria filaments by coupling their respective genetic circuits via molecular diffusion. These two ingredients allow us to understand the principles by which heterocyst patterns can be generated and sustained. In particular, our results point out that, by including both diffusion and noisy external conditions in the computational model, it is possible to reproduce the main features of the formation and sustainment of heterocyst patterns in cyanobacteria filaments as observed experimentally. Finally, we discuss the validity and possible improvements of the model.

  16. An Integrated Approach to Biology

    Indian Academy of Sciences (India)

    An Integrated Approach to Biology. Aniket Bhattacharya. Keywords. Zoology, genomics, schistoso- miasis, schistosome genomics, praziquantel, origin of clothing. Zoology, being a basic bioscience, is essential for a better understanding of applied biological disciplines. A sound back- ground in zoology can often be the key ...

  17. An Integrated Approach to Biology

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 8. An Integrated Approach to Biology. Aniket Bhattacharya. General Article Volume 16 Issue 8 August 2011 pp 742-753 ... Keywords. Zoology; genomics; schistosomiasis; schistosome genomics; praziquantel; origin of clothing.

  18. Considering the energy, water and food nexus: Towards an integrated modelling approach

    International Nuclear Information System (INIS)

    Bazilian, Morgan; Rogner, Holger; Howells, Mark; Hermann, Sebastian; Arent, Douglas; Gielen, Dolf; Steduto, Pasquale; Mueller, Alexander; Komor, Paul; Tol, Richard S.J.; Yumkella, Kandeh K.

    2011-01-01

    The areas of energy, water and food policy have numerous interwoven concerns ranging from ensuring access to services, to environmental impacts to price volatility. These issues manifest in very different ways in each of the three “spheres”, but often the impacts are closely related. Identifying these interrelationships a priori is of great importance to help target synergies and avoid potential tensions. Systems thinking is required to address such a wide swath of possible topics. This paper briefly describes some of the linkages at a high-level of aggregation – primarily from a developing country perspective – and via case studies, to arrive at some promising directions for addressing the nexus. To that end, we also present the attributes of a modelling framework that specifically addresses the nexus, and can thus serve to inform more effective national policies and regulations. While environmental issues are normally the ‘cohesive principle’ from which the three areas are considered jointly, the enormous inequalities arising from a lack of access suggest that economic and security-related issues may be stronger motivators of change. Finally, consideration of the complex interactions will require new institutional capacity both in industrialised and developing countries.

  19. SIMILARITIES BETWEEN THE KNOWLEDGE CREATION AND CONVERSION MODEL AND THE COMPETING VALUES FRAMEWORK: AN INTEGRATIVE APPROACH

    Directory of Open Access Journals (Sweden)

    PAULO COSTA

    2016-12-01

    Full Text Available ABSTRACT Contemporaneously, and with the successive paradigmatic revolutions inherent to management since the XVII century, we are witnessing a new era marked by the structural rupture in the way organizations are perceived. Market globalization, cemented by quick technological evolutions, associated with economic, cultural, political and social transformations characterize a reality where uncertainty is the only certainty for organizations and managers. Knowledge management has been interpreted by managers and academics as a viable alternative in a logic of creation and conversation of sustainable competitive advantages. However, there are several barriers to the implementation and development of knowledge management programs in organizations, with organizational culture being one of the most preponderant. In this sense, and in this article, we will analyze and compare The Knowledge Creation and Conversion Model proposed by Nonaka and Takeuchi (1995 and Quinn and Rohrbaugh's Competing Values Framework (1983, since both have convergent conceptual lines that can assist managers in different sectors to guide their organization in a perspective of productivity, quality and market competitiveness.

  20. Integrated approaches to physical Therapy education: a new comprehensive model from the University of Illinois Chicago.

    Science.gov (United States)

    Arena, Ross; Girolami, Gay; Aruin, Alexander; Keil, Aaron; Sainsbury, Jenna; Phillips, Shane A

    2017-05-01

    Demand for physical therapists in the United States (U.S.) is currently robust and expected to grow further. There are currently 228 physical therapy programs accredited by the Commission on Accreditation in Physical Therapy Education (CAPTE), and 30 more are in development in the U.S.; 29,246 students are currently enrolled in these programs (2014-2015 data). A shortage of physical therapy faculty with an advanced doctoral degree (i.e., PhD, EdD, DSc) is a primary concern for these programs. Specialized residency and fellowship training in physical therapy continue to expand, preparing professionals to deliver advanced clinical care. The American Board of Physical Therapy Residency and Fellowship Education (ABPTRFE) reports that there are currently 179 accredited residency programs and 35 accredited fellowship programs in the U.S. A number of academic physical therapy programs also currently operate a clinical faculty practice. Currently, these aspects and trends in physical therapy education, advanced training, and clinical practice, for the most part, lack synergy and connectivity, in both planning and implementation amongst the various components. This professional theoretical article describes a novel model for academic physical therapy, with potential transformative implications for entry-level physical therapy education, advanced clinical training, and academic preparation.

  1. Integration of a modeling task in water policy design - Example of a prospective scenarios approach on an agricultural catchment

    Science.gov (United States)

    Moreau, P.; Raimbault, T.; Durand, P.; Gascuel-Odoux, C.; Salmon-Monviola, J.; Masson, V.; Cordier, M. O.

    2010-05-01

    To meet the objectives of the Water Framework Directive in terms of nitrate pollution of surface water, numerous mitigation options have been proposed. To support stakeholders' decision prior to the implementation of regulations, scenario analysis by models can be used as a prospective approach. The work developed an extensive virtual experiment design from an initial basic requirement of catchment managers. Specific objectives were (1) to test the ability of a distributed model (TNT2) to simulate hydrology and hydrochemistry on a watershed with a high diversity of production systems, (2) to analyse a large set of scenarios and their effects on water quality and (3) to propose an effective mode of communication between research scientists and catchment managers. The focus of the scenario, in accord with catchment managers' requirement, is put on winter catch crop (CC). 5 conditions of implantation in rotations, 3 CC durations and 2 CC harvest modes were tested. CC is favoured by managers because of its simplicity to implement on fields and its relative low influence on farm strategy. Calibration and validation periods were run from 1998 to 2007 and scenario simulation period from 2007 to 2020. Results have been provided, for each scenario, by compartment (soil, atmosphere, plant uptake, water) but especially in the form of nitrogen mass balance at the catchment scale. The scenarios were ranked by integrating positive and negative effects of each measure. This 3-step-process: translation of a simple stakeholder question into extensive set of scenarios (complexification) - modeling process and data analysis - restitution to catchments' manager into a simple integrative form (simplification), gives an operational tool for decision support. In term of water quality, the best improvements in nitrate concentrations at the outlet reached a decrease of 0.8 mgL-1 compared to a "business as usual" scenario and were achieved by exporting the CC residue, by extending CC

  2. Integrated remote sensing imagery and two-dimensional hydraulic modeling approach for impact evaluation of flood on crop yields

    Science.gov (United States)

    Chen, Huili; Liang, Zhongyao; Liu, Yong; Liang, Qiuhua; Xie, Shuguang

    2017-10-01

    , with the SCS-CN model as a rainfall-runoff generator and the two-dimensional hydraulic model implementing the routing scheme for surface runoff; and (c) The spatial combination between crop yield losses and flood dynamics on a grid scale can be used to investigate the relationship between the intensity of flood characteristics and associated loss extent. The modeling framework was applied for a 50-year return period flood that occurred in Jilin province, Northeast China, which caused large agricultural losses in August 2013. The modeling results indicated that (a) the flow velocity was the most influential factor that caused spring corn, rice and soybean yield losses from extreme storm event in the mountainous regions; (b) the power function archived the best results that fit the velocity-loss relationship for mountainous areas; and (c) integrated remote sensing imagery and two-dimensional hydraulic modeling approach are helpful for evaluating the influence of historical flood event on crop production and investigating the relationship between flood characteristics and crop yield losses.

  3. An Integrative Observing and Modeling Approach for the Physiological Understanding of Sun-Induced Chlorophyll Fluorescence in Japan

    Science.gov (United States)

    Kobayashi, H.; Kato, T.; Saitoh, Y.; Noda, H.; Kikosaka, K.; Ichii, K.; Nasahara, K. N.

    2016-12-01

    Satellite-derived sun-induced chlorophyll fluorescence (SIF) is expected to provides a pathway to link leaf level photosynthesis to global GPP. Existing studies have stressed how well the satellite-derived SIF is correlated with the eddy covariance and/or modeled GPPs. There are some challenges in SIF interpretation because the satellite-derived SIF is a mixture of fluorescence emission from sunlit and shaded leaves and multiple scatterings of fluorescence within plant canopies. In this presentation, we show observation and modeling results around Japan and discuss how the integrative observing and modeling approach potentially overcomes the gaps in-between satellite SIF and photosynthesis reaction within leaves. We have analyzed ground-based SIF monitoring systems "Phenological Eye Network (PEN)". PEN covers several eddy flux sites in Japan and is equipped with spectroradiometer (MS-700) since 2003 (at an earliest site). The computed seasonal SIF variations in the different ecosystems show environmental dependency of SIF and GPP. Another ground-based system we are now developing is the vegetation lidar system named LIFS (Laser-Induced Fluorescence Spectrum), which can offer eco-physiological information of plants. LIFS is consisted of a pulsed UV (355 nm) laser, a telescope, a spectrometer/filter, and a gated image-intensified CCD detector. This system has been using to remotely monitor tree growth status, chlorophyll contents in leaves and so on. The physical and physiological theories are necessary for understanding the observed SIF under various environmental conditions. We have been developing leaf to plant canopy scale photosynthesis and SIF models as precise as possible. The developed model has been used to understand how the leaf-level SIF emission can be related to the canopy scale SIF, which enables to investigate the top of canopy SIF observed from ground-based and satellite-derived SIF measurements.

  4. A Stackelberg Game Approach in an Integrated Inventory Model with Carbon-Emission and Setup Cost Reduction

    Directory of Open Access Journals (Sweden)

    Biswajit Sarkar

    2016-12-01

    Full Text Available This paper formulates an integrated inventory model that allows Stackelberg game policy for optimizing joint total cost of a vendor and buyer system. After receiving the lot, the buyer commences an inspection process to determine the defective items. All defective items the buyer sends to vendor during the receiving of the next lot. Due to increasing number of shipments fixed and variable transportation, as well as carbon emissions, are considered, which makes the model sustainable integrated model forever. To reduce the setup cost for the vendor, a discrete setup reduction is considered for maximization more profit. The players of the integrated model are with unequal power (as leader and follower and the Stackelberg game strategy is utilized to solve this model for obtaining global optimum solution over the finite planning horizon. An illustrative numerical example is given to understand this model clearly.

  5. An Integrated model for Product Quality Development—A case study on Quality functions deployment and AHP based approach

    Science.gov (United States)

    Maitra, Subrata; Banerjee, Debamalya

    2010-10-01

    Present article is based on application of the product quality and improvement of design related with the nature of failure of machineries and plant operational problems of an industrial blower fan Company. The project aims at developing the product on the basis of standardized production parameters for selling its products in the market. Special attention is also being paid to the blower fans which have been ordered directly by the customer on the basis of installed capacity of air to be provided by the fan. Application of quality function deployment is primarily a customer oriented approach. Proposed model of QFD integrated with AHP to select and rank the decision criterions on the commercial and technical factors and the measurement of the decision parameters for selection of best product in the compettitive environment. The present AHP-QFD model justifies the selection of a blower fan with the help of the group of experts' opinion by pairwise comparison of the customer's and ergonomy based technical design requirements. The steps invoved in implementation of the QFD—AHP and selection of weighted criterion may be helpful for all similar purpose industries maintaining cost and utility for competitive product.

  6. Approach to Integrate Global-Sun Models of Magnetic Flux Emergence and Transport for Space Weather Studies

    Science.gov (United States)

    Mansour, Nagi N.; Wray, Alan A.; Mehrotra, Piyush; Henney, Carl; Arge, Nick; Godinez, H.; Manchester, Ward; Koller, J.; Kosovichev, A.; Scherrer, P.; hide

    2013-01-01

    The Sun lies at the center of space weather and is the source of its variability. The primary input to coronal and solar wind models is the activity of the magnetic field in the solar photosphere. Recent advancements in solar observations and numerical simulations provide a basis for developing physics-based models for the dynamics of the magnetic field from the deep convection zone of the Sun to the corona with the goal of providing robust near real-time boundary conditions at the base of space weather forecast models. The goal is to develop new strategic capabilities that enable characterization and prediction of the magnetic field structure and flow dynamics of the Sun by assimilating data from helioseismology and magnetic field observations into physics-based realistic magnetohydrodynamics (MHD) simulations. The integration of first-principle modeling of solar magnetism and flow dynamics with real-time observational data via advanced data assimilation methods is a new, transformative step in space weather research and prediction. This approach will substantially enhance an existing model of magnetic flux distribution and transport developed by the Air Force Research Lab. The development plan is to use the Space Weather Modeling Framework (SWMF) to develop Coupled Models for Emerging flux Simulations (CMES) that couples three existing models: (1) an MHD formulation with the anelastic approximation to simulate the deep convection zone (FSAM code), (2) an MHD formulation with full compressible Navier-Stokes equations and a detailed description of radiative transfer and thermodynamics to simulate near-surface convection and the photosphere (Stagger code), and (3) an MHD formulation with full, compressible Navier-Stokes equations and an approximate description of radiative transfer and heating to simulate the corona (Module in BATS-R-US). CMES will enable simulations of the emergence of magnetic structures from the deep convection zone to the corona. Finally, a plan

  7. Integrated Approach to User Account Management

    Science.gov (United States)

    Kesselman, Glenn; Smith, William

    2007-01-01

    IT environments consist of both Windows and other platforms. Providing user account management for this model has become increasingly diffi cult. If Microsoft#s Active Directory could be enhanced to extend a W indows identity for authentication services for Unix, Linux, Java and Macintosh systems, then an integrated approach to user account manag ement could be realized.

  8. Ares I Integrated Test Approach

    Science.gov (United States)

    Taylor, Jim

    2008-01-01

    This slide presentation reviews the testing approach that NASA is developing for the Ares I launch vehicle. NASA is planning a complete series of development, qualification and verification tests. These include: (1) Upper stage engine sea-level and altitude testing (2) First stage development and qualification motors (3) Upper stage structural and thermal development and qualification test articles (4) Main Propulsion Test Article (MPTA) (5) Upper stage green run testing (6) Integrated Vehicle Ground Vibration Testing (IVGVT) and (7) Aerodynamic characterization testing.

  9. An Integrated and Multivariate Model along with Designing Experiments Approach for Assessment of Micro- and Macro- Ergonomic Factors: The Case of a Gas Refinery.

    Science.gov (United States)

    Azadeh, A; Mohammadfam, I; Sadjadi, M; Hamidi, Y; Kianfar, A

    2008-12-28

    The objectives of this paper are three folds. First, an integrated framework for designing and development of the integrated health, safety and environment (HSE) model is presented. Second, it is implemented and tested for a large gas refinery in Iran. Third, it is shown whether the total ergonomics model is superior to the conventional ergonomics approach. This study is among the first to examine total ergonomics components in a manufacturing system. This study was conducted in Sarkhoon & Qeshm Gas refinery- Iran in 2006. To achieve the above objectives, an integrated approach based on total ergonomics factors was developed. Second, it is applied to the refinery and the advantages of total ergonomics approach are discussed. Third, the impacts of total ergonomics factors on local factors are examined through non-parametric statistical analysis. It was shown that total ergonomics model is much more beneficial than conventional approach. It should be noted that the traditional ergonomics methodology is not capable of locating the findings of total ergonomics model. The distinguished aspect of this study is the employment of a total system approach based on integration of the conventional ergonomics factors with HSE factors.

  10. Bending of Euler-Bernoulli nanobeams based on the strain-driven and stress-driven nonlocal integral models: a numerical approach

    Science.gov (United States)

    Oskouie, M. Faraji; Ansari, R.; Rouhi, H.

    2018-04-01

    Eringen's nonlocal elasticity theory is extensively employed for the analysis of nanostructures because it is able to capture nanoscale effects. Previous studies have revealed that using the differential form of the strain-driven version of this theory leads to paradoxical results in some cases, such as bending analysis of cantilevers, and recourse must be made to the integral version. In this article, a novel numerical approach is developed for the bending analysis of Euler-Bernoulli nanobeams in the context of strain- and stress-driven integral nonlocal models. This numerical approach is proposed for the direct solution to bypass the difficulties related to converting the integral governing equation into a differential equation. First, the governing equation is derived based on both strain-driven and stress-driven nonlocal models by means of the minimum total potential energy. Also, in each case, the governing equation is obtained in both strong and weak forms. To solve numerically the derived equations, matrix differential and integral operators are constructed based upon the finite difference technique and trapezoidal integration rule. It is shown that the proposed numerical approach can be efficiently applied to the strain-driven nonlocal model with the aim of resolving the mentioned paradoxes. Also, it is able to solve the problem based on the strain-driven model without inconsistencies of the application of this model that are reported in the literature.

  11. Integrated Medical Model Overview

    Science.gov (United States)

    Myers, J.; Boley, L.; Foy, M.; Goodenow, D.; Griffin, D.; Keenan, A.; Kerstman, E.; Melton, S.; McGuire, K.; Saile, L.; hide

    2015-01-01

    The Integrated Medical Model (IMM) Project represents one aspect of NASA's Human Research Program (HRP) to quantitatively assess medical risks to astronauts for existing operational missions as well as missions associated with future exploration and commercial space flight ventures. The IMM takes a probabilistic approach to assessing the likelihood and specific outcomes of one hundred medical conditions within the envelope of accepted space flight standards of care over a selectable range of mission capabilities. A specially developed Integrated Medical Evidence Database (iMED) maintains evidence-based, organizational knowledge across a variety of data sources. Since becoming operational in 2011, version 3.0 of the IMM, the supporting iMED, and the expertise of the IMM project team have contributed to a wide range of decision and informational processes for the space medical and human research community. This presentation provides an overview of the IMM conceptual architecture and range of application through examples of actual space flight community questions posed to the IMM project.

  12. Building a model for disease classification integration in oncology, an approach based on the national cancer institute thesaurus.

    Science.gov (United States)

    Jouhet, Vianney; Mougin, Fleur; Bréchat, Bérénice; Thiessard, Frantz

    2017-02-07

    Identifying incident cancer cases within a population remains essential for scientific research in oncology. Data produced within electronic health records can be useful for this purpose. Due to the multiplicity of providers, heterogeneous terminologies such as ICD-10 and ICD-O-3 are used for oncology diagnosis recording purpose. To enable disease identification based on these diagnoses, there is a need for integrating disease classifications in oncology. Our aim was to build a model integrating concepts involved in two disease classifications, namely ICD-10 (diagnosis) and ICD-O-3 (topography and morphology), despite their structural heterogeneity. Based on the NCIt, a "derivative" model for linking diagnosis and topography-morphology combinations was defined and built. ICD-O-3 and ICD-10 codes were then used to instantiate classes of the "derivative" model. Links between terminologies obtained through the model were then compared to mappings provided by the Surveillance, Epidemiology, and End Results (SEER) program. The model integrated 42% of neoplasm ICD-10 codes (excluding metastasis), 98% of ICD-O-3 morphology codes (excluding metastasis) and 68% of ICD-O-3 topography codes. For every codes instantiating at least a class in the "derivative" model, comparison with SEER mappings reveals that all mappings were actually available in the model as a link between the corresponding codes. We have proposed a method to automatically build a model for integrating ICD-10 and ICD-O-3 based on the NCIt. The resulting "derivative" model is a machine understandable resource that enables an integrated view of these heterogeneous terminologies. The NCIt structure and the available relationships can help to bridge disease classifications taking into account their structural and granular heterogeneities. However, (i) inconsistencies exist within the NCIt leading to misclassifications in the "derivative" model, (ii) the "derivative" model only integrates a part of ICD-10 and ICD

  13. An Overview of Modeling Approaches Applied to Aggregation-Based Fleet Management and Integration of Plug-in Electric Vehicles †

    DEFF Research Database (Denmark)

    You, Shi; Hu, Junjie; Ziras, Charalampos

    2016-01-01

    and systems are seen as useful tools to support the related studies for different stakeholders in a tangible way. This paper presents an overview of modeling approaches applied to support aggregation-based management and integration of PEVs from the perspective of fleet operators and grid operators...... management, and key systems, such as the PEV fleet, is then presented, along with a detailed description of different approaches. Finally, we discuss several considerations that need to be well understood during the modeling process in order to assist modelers and model users in the appropriate decisions...

  14. Integrated Ecological-Economic Models

    OpenAIRE

    John Tschirhart

    2009-01-01

    Scientific evidence suggests that economic activity is threatening global biodiversity in ways that could severely degrade nature's flow of ecosystem services. Yet, there is relatively little work in economics that addresses biodiversity loss. Some economists have called for better integration of economic and ecological models to address biodiversity and the attendant ecosystem services. Current integrated approaches in economics are discussed, and they take in ecosystem services, ecosystem e...

  15. Performance improvement integration: a whole systems approach.

    Science.gov (United States)

    Page, C K

    1999-02-01

    Performance improvement integration in health care organizations is a challenge for health care leaders. Required for accreditation by the Joint Commission on Accreditation of Healthcare Organizations (Joint Commission), performance improvement (PI) can be designed as a sustainable model for performance to survive in a turbulent period. Central Baptist Hospital developed a model for PI that focused on strategy established by the leadership team, delineated responsibility through the organizational structure of shared governance, and accountability for outcomes evidenced through the organization's profitability. Such an approach integrated into the culture of the organization can produce positive financial margins, positive customer satisfaction, and commendations from the Joint Commission.

  16. An efficient approach to bioconversion kinetic model generation based on automated microscale experimentation integrated with model driven experimental design

    DEFF Research Database (Denmark)

    Chen, B. H.; Micheletti, M.; Baganz, F.

    2009-01-01

    Reliable models of enzyme kinetics are required for the effective design of bioconversion processes. Kinetic expressions of the enzyme-catalysed reaction rate however, are frequently complex and establishing accurate values of kinetic parameters normally requires a large number of experiments. Th...

  17. An Integrated Modelling and Toolpathing Approach for a Frameless Stressed Skin Structure, Fabricated Using Robotic Incremental Sheet Forming

    DEFF Research Database (Denmark)

    Nicholas, Paul; Stasiuk, David; Nørgaard, Esben Clausen

    2016-01-01

    For structural assemblies that depend upon robotic incremental sheet forming (ISF) the rigidity, connectivity, customization and aesthetics play an important role for an integrated and accurate modeling process. Furthermore, it is critical to consider fabrication and forming parameters jointly...... with calculated and observed micro behaviour; the organisation and extraction of toolpaths; and rig setup logics for fabrication. Finally, the validity of these models is evaluated for structural performance, and for geometric accuracy at multiple scales....

  18. Integrated Case-Based Applied Pathology (ICAP): a diagnostic-approach model for the learning and teaching of veterinary pathology.

    Science.gov (United States)

    Krockenberger, Mark B; Bosward, Katrina L; Canfield, Paul J

    2007-01-01

    Integrative Case-Based Applied Pathology (ICAP) cases form one component of learning and understanding the role of pathology in the veterinary diagnostic process at the Faculty of Veterinary Science, University of Sydney. It is a strategy that focuses on student-centered learning in a problem-solving context in the year 3 curriculum. Learning exercises use real case material and are primarily delivered online, providing flexibility for students with differing learning needs, who are supported by online, peer, and tutor support. The strategy relies heavily on the integration of pre-clinical and para-clinical information with the introduction of clinical material for the purposes of a logical three-level, problem-oriented approach to the diagnosis of disease. The focus is on logical diagnostic problem solving, primarily using gross pathology and histopathological material, with the inclusion of microbiological, parasitological, and clinical pathological data. The ICAP approach is linked to and congruent with the problem-oriented approach adopted in veterinary medicine and the case-based format used by one of the authors (PJC) for the teaching and learning of veterinary clinical pathology in year 4. Additionally, final-year students have the opportunity, during a diagnostic pathology rotation, to assist in the development and refinement of further ICAPs, which reinforces the importance of pathology in the veterinary diagnostic process. Evidence of the impact of the ICAP approach, based primarily on student surveys and staff peer feedback collected over five years, shows that discipline-specific learning, vertical and horizontal integration, alignment of learning outcomes and assessment, and both veterinary and generic graduate attributes were enhanced. Areas for improvement were identified in the approach, most specifically related to assistance in the development of generic teamwork skills.

  19. An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production.

    Science.gov (United States)

    Ihekwaba, Adaoha E C; Mura, Ivan; Walshaw, John; Peck, Michael W; Barker, Gary C

    2016-11-01

    Clostridium botulinum produces botulinum neurotoxins (BoNTs), highly potent substances responsible for botulism. Currently, mathematical models of C. botulinum growth and toxigenesis are largely aimed at risk assessment and do not include explicit genetic information beyond group level but integrate many component processes, such as signalling, membrane permeability and metabolic activity. In this paper we present a scheme for modelling neurotoxin production in C. botulinum Group I type A1, based on the integration of diverse information coming from experimental results available in the literature. Experiments show that production of BoNTs depends on the growth-phase and is under the control of positive and negative regulatory elements at the intracellular level. Toxins are released as large protein complexes and are associated with non-toxic components. Here, we systematically review and integrate those regulatory elements previously described in the literature for C. botulinum Group I type A1 into a population dynamics model, to build the very first computational model of toxin production at the molecular level. We conduct a validation of our model against several items of published experimental data for different wild type and mutant strains of C. botulinum Group I type A1. The result of this process underscores the potential of mathematical modelling at the cellular level, as a means of creating opportunities in developing new strategies that could be used to prevent botulism; and potentially contribute to improved methods for the production of toxin that is used for therapeutics.

  20. Model integration and a theory of models

    OpenAIRE

    Dolk, Daniel R.; Kottemann, Jeffrey E.

    1993-01-01

    Model integration extends the scope of model management to include the dimension of manipulation as well. This invariably leads to comparisons with database theory. Model integration is viewed from four perspectives: Organizational, definitional, procedural, and implementational. Strategic modeling is discussed as the organizational motivation for model integration. Schema and process integration are examined as the logical and manipulation counterparts of model integr...

  1. A Database Approach to Computer Integrated Manufacturing

    Science.gov (United States)

    1988-06-01

    BACKGROUND .......................................................................................... 28 B. WHAT IS COMPUTER INTEGRATED MANUFACTURING...CIM is a modular approach to integration. B. WHAT IS COMPUTER INTEGRATED MANUFACTURING? There is a wide diversity of definitions of CIM in the

  2. Integration of anatomical and external response mappings explains crossing effects in tactile localization: A probabilistic modeling approach.

    Science.gov (United States)

    Badde, Stephanie; Heed, Tobias; Röder, Brigitte

    2016-04-01

    To act upon a tactile stimulus its original skin-based, anatomical spatial code has to be transformed into an external, posture-dependent reference frame, a process known as tactile remapping. When the limbs are crossed, anatomical and external location codes are in conflict, leading to a decline in tactile localization accuracy. It is unknown whether this impairment originates from the integration of the resulting external localization response with the original, anatomical one or from a failure of tactile remapping in crossed postures. We fitted probabilistic models based on these diverging accounts to the data from three tactile localization experiments. Hand crossing disturbed tactile left-right location choices in all experiments. Furthermore, the size of these crossing effects was modulated by stimulus configuration and task instructions. The best model accounted for these results by integration of the external response mapping with the original, anatomical one, while applying identical integration weights for uncrossed and crossed postures. Thus, the model explained the data without assuming failures of remapping. Moreover, performance differences across tasks were accounted for by non-individual parameter adjustments, indicating that individual participants' task adaptation results from one common functional mechanism. These results suggest that remapping is an automatic and accurate process, and that the observed localization impairments in touch result from a cognitively controlled integration process that combines anatomically and externally coded responses.

  3. INTEGRATED CORPORATE STRATEGY MODEL

    Directory of Open Access Journals (Sweden)

    CATALINA SORIANA SITNIKOV

    2014-02-01

    Full Text Available Corporations are at present operating in demanding and highly unsure periods, facing a mixture of increased macroeconomic need, competitive and capital market dangers, and in many cases, the prospect for significant technical and regulative gap. Throughout these demanding and highly unsure times, the corporations must pay particular attention to corporate strategy. In present times, corporate strategy must be perceived and used as a function of various fields, covers, and characters as well as a highly interactive system. For the corporation's strategy to become a competitive advantage is necessary to understand and also to integrate it in a holistic model to ensure sustainable progress of corporation activities under the optimum conditions of profitability. The model proposed in this paper is aimed at integrating the two strategic models, Hoshin Kanri and Integrated Strategy Model, as well as their consolidation with the principles of sound corporate governance set out by the OECD.

  4. Accelerated Model Predictive Control for Electric Vehicle Integrated Microgrid Energy Management: A Hybrid Robust and Stochastic Approach

    Directory of Open Access Journals (Sweden)

    Zhenya Ji

    2016-11-01

    Full Text Available A microgrid with an advanced energy management approach is a feasible solution for accommodating the development of distributed generators (DGs and electric vehicles (EVs. At the primary stage of development, the total number of EVs in a microgrid is fairly small but increases promptly. Thus, it makes most prediction models for EV charging demand difficult to apply at present. To overcome the inadaptability, a novel robust approach is proposed to handle EV charging demand predictions along with demand-side management (DSM on the condition of satisfying each EV user’s demand. Variables with stochastic forecast models join the objective function in the form of probability-constrained scenarios. This paper proposes a scenario-based model predictive control (MPC approach combining both robust and stochastic models to minimize the total operational cost for energy management. To overcome the concern about the convergence time increasing from the combination of scenarios, the Benders decomposition (BD technique is further adopted to improve computational efficiency. Simulation results on a combined heat and power microgrid indicate that the proposed scenario-based MPC approach achieves a better economic performance than a traditional deterministic MPC (DMPC approach, while ensuring EV charging demands, as well as minimizing the trade-off between optimal solutions and computing times.

  5. An integral equation approach to the interval reliability of systems modelled by finite semi-Markov processes

    International Nuclear Information System (INIS)

    Csenki, A.

    1995-01-01

    The interval reliability for a repairable system which alternates between working and repair periods is defined as the probability of the system being functional throughout a given time interval. In this paper, a set of integral equations is derived for this dependability measure, under the assumption that the system is modelled by an irreducible finite semi-Markov process. The result is applied to the semi-Markov model of a two-unit system with sequential preventive maintenance. The method used for the numerical solution of the resulting system of integral equations is a two-point trapezoidal rule. The system of implementation is the matrix computation package MATLAB on the Apple Macintosh SE/30. The numerical results are discussed and compared with those from simulation

  6. Statistical inference an integrated approach

    CERN Document Server

    Migon, Helio S; Louzada, Francisco

    2014-01-01

    Introduction Information The concept of probability Assessing subjective probabilities An example Linear algebra and probability Notation Outline of the bookElements of Inference Common statistical modelsLikelihood-based functions Bayes theorem Exchangeability Sufficiency and exponential family Parameter elimination Prior Distribution Entirely subjective specification Specification through functional forms Conjugacy with the exponential family Non-informative priors Hierarchical priors Estimation Introduction to decision theoryBayesian point estimation Classical point estimation Empirical Bayes estimation Comparison of estimators Interval estimation Estimation in the Normal model Approximating Methods The general problem of inference Optimization techniquesAsymptotic theory Other analytical approximations Numerical integration methods Simulation methods Hypothesis Testing Introduction Classical hypothesis testingBayesian hypothesis testing Hypothesis testing and confidence intervalsAsymptotic tests Prediction...

  7. Evaluating Pain Education Programs: An Integrated Approach

    Directory of Open Access Journals (Sweden)

    Adam Dubrowski

    2011-01-01

    Full Text Available Evaluation of educational programs and assessment of learning are essential to maintain high-standard health science education, which includes pain education. Current models of program evaluations applied to the education of the health professions, such as the Kirkpatrick model, are mainly outcome based. More recently, efforts have been made to examine other process-based models such as the Context Input Process Product model. The present article proposes an approach that integrates both outcome- and process-based models with models of clinical performance assessment to provide a deeper understanding of a program function. Because assessment instruments are a critical part of program evaluation, it is suggested that standardization and rigour should be used in their selection, development and adaptation. The present article suggests an alternative to currently used models in pain education evaluation.

  8. DOE systems approach and integration

    International Nuclear Information System (INIS)

    Logan, J.A.

    1987-01-01

    Six sites are now disposing of most of DOE's currently generated waste. These are: Hanford, Idaho National Engineering Laboratory, Los Alamos National Laboratory, the Nevada Test Site, Oak Ridge, and Savannah River. Within DOE, experience with disposal of solid LLW has been that arid site disposal facilities (first four) appear to have performed well, while humid site disposal facilities (last two) have experienced some waste migration. DOE's intent, of course, is to operate all its waste disposal facilities so that public health and safety are not adversely affected. To ensure that this continues to be the case, activities are underway to increase use of waste form stabilization and engineered barriers where appropriate. For the sake of overall economy, these measures are to be applied as and where needed, through use of the systems approach. In this paper the author discusses two topics: the system approach, which DOE has decided to use for resolving waste disposal problems in the management of DOE's low-level wastes; and DOE's intended integration of activities underway at the waste management systems throughout DOE facilities. 2 figures

  9. Integrated modeling for the VLTI

    Science.gov (United States)

    Muller, Michael; Wilhelm, Rainer C.; Baier, Horst J.; Koch, Franz

    2004-07-01

    Within the scope of the Very Large Telescope Interferometer (VLTI) project, ESO has developed a software package for integrated modeling of single- and multi-aperture optical telescopes. Integrated modeling is aiming at time-dependent system analysis combining different technical disciplines (optics, mechanical structure, control system with sensors and actuators, environmental disturbances). This allows multi-disciplinary analysis and gives information about cross-coupling effects for system engineering of complex stellar interferometers and telescopes. At the moment the main components of the Integrated Modeling Toolbox are BeamWarrior, a numerical tool for optical analysis of single- and multi-aperture telescopes, and the Structural Modeling Interface, which allows to generate Simulink blocks with reduced size from Finite Element Models of a telescope structure. Based on these tools, models of the various subsystems (e.g. telescope, delay line, beam combiner, atmosphere) can be created in the appropriate disciplines (e.g. optics, structure, disturbance). All subsystem models are integrated into the Matlab/Simulink environment for dynamic control system simulations. The basic output of the model is a complete description of the time-dependent electromagnetic field in each interferometer arm. Alternatively, a more elaborated output can be created, such as an interference fringe pattern at the focus of a beam combining instrument. The concern of this paper is the application of the modeling concept to large complex telescope systems. The concept of the Simulink-based integrated model with the main components telescope structure, optics and control loops is presented. The models for wind loads and atmospheric turbulence are explained. Especially the extension of the modeling approach to a 50 - 100 m class telescope is discussed.

  10. An integrated modeling approach for estimating the water quality benefits of conservation practices at the river basin scale.

    Science.gov (United States)

    Santhi, C; Kannan, N; White, M; Di Luzio, M; Arnold, J G; Wang, X; Williams, J R

    2014-01-01

    The USDA initiated the Conservation Effects Assessment Project (CEAP) to quantify the environmental benefits of conservation practices at regional and national scales. For this assessment, a sampling and modeling approach is used. This paper provides a technical overview of the modeling approach used in CEAP cropland assessment to estimate the off-site water quality benefits of conservation practices using the Ohio River Basin (ORB) as an example. The modeling approach uses a farm-scale model, Agricultural Policy Environmental Extender (APEX), and a watershed scale model (the Soil and Water Assessment Tool [SWAT]) and databases in the Hydrologic Unit Modeling for the United States system. Databases of land use, soils, land use management, topography, weather, point sources, and atmospheric depositions were developed to derive model inputs. APEX simulates the cultivated cropland, Conserve Reserve Program land, and the practices implemented on them, whereas SWAT simulates the noncultivated land (e.g., pasture, range, urban, and forest) and point sources. Simulation results from APEX are input into SWAT. SWAT routes all sources, including APEX's, to the basin outlet through each eight-digit watershed. Each basin is calibrated for stream flow, sediment, and nutrient loads at multiple gaging sites and turned in for simulating the effects of conservation practice scenarios on water quality. Results indicate that sediment, nitrogen, and phosphorus loads delivered to the Mississippi River from ORB could be reduced by 16, 15, and 23%, respectively, due to current conservation practices. Modeling tools are useful to provide science-based information for assessing existing conservation programs, developing future programs, and developing insights on load reductions necessary for hypoxia in the Gulf of Mexico. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  11. Framework for Infectious Disease Analysis: A comprehensive and integrative multi-modeling approach to disease prediction and management.

    Science.gov (United States)

    Erraguntla, Madhav; Zapletal, Josef; Lawley, Mark

    2017-12-01

    The impact of infectious disease on human populations is a function of many factors including environmental conditions, vector dynamics, transmission mechanics, social and cultural behaviors, and public policy. A comprehensive framework for disease management must fully connect the complete disease lifecycle, including emergence from reservoir populations, zoonotic vector transmission, and impact on human societies. The Framework for Infectious Disease Analysis is a software environment and conceptual architecture for data integration, situational awareness, visualization, prediction, and intervention assessment. Framework for Infectious Disease Analysis automatically collects biosurveillance data using natural language processing, integrates structured and unstructured data from multiple sources, applies advanced machine learning, and uses multi-modeling for analyzing disease dynamics and testing interventions in complex, heterogeneous populations. In the illustrative case studies, natural language processing from social media, news feeds, and websites was used for information extraction, biosurveillance, and situation awareness. Classification machine learning algorithms (support vector machines, random forests, and boosting) were used for disease predictions.

  12. Simulating Human and Environmental Exposure from Hand-Held Knapsack Pesticide Application: Be-WetSpa-Pest, an Integrative, Spatially Explicit Modeling Approach.

    Science.gov (United States)

    Binder, Claudia R; García-Santos, Glenda; Andreoli, Romano; Diaz, Jaime; Feola, Giuseppe; Wittensoeldner, Moritz; Yang, Jing

    2016-05-25

    This paper presents an integrative and spatially explicit modeling approach for analyzing human and environmental exposure from pesticide application of smallholders in the potato-producing Andean region in Colombia. The modeling approach fulfills the following criteria: (i) it includes environmental and human compartments; (ii) it contains a behavioral decision-making model for estimating the effect of policies on pesticide flows to humans and the environment; (iii) it is spatially explicit; and (iv) it is modular and easily expandable to include additional modules, crops, or technologies. The model was calibrated and validated for the Vereda La Hoya and was used to explore the effect of different policy measures in the region. The model has moderate data requirements and can be adapted relatively easily to other regions in developing countries with similar conditions.

  13. An integrated approach for the knowledge discovery in computer simulation models with a multi-dimensional parameter space

    Science.gov (United States)

    Khawli, Toufik Al; Gebhardt, Sascha; Eppelt, Urs; Hermanns, Torsten; Kuhlen, Torsten; Schulz, Wolfgang

    2016-06-01

    In production industries, parameter identification, sensitivity analysis and multi-dimensional visualization are vital steps in the planning process for achieving optimal designs and gaining valuable information. Sensitivity analysis and visualization can help in identifying the most-influential parameters and quantify their contribution to the model output, reduce the model complexity, and enhance the understanding of the model behavior. Typically, this requires a large number of simulations, which can be both very expensive and time consuming when the simulation models are numerically complex and the number of parameter inputs increases. There are three main constituent parts in this work. The first part is to substitute the numerical, physical model by an accurate surrogate model, the so-called metamodel. The second part includes a multi-dimensional visualization approach for the visual exploration of metamodels. In the third part, the metamodel is used to provide the two global sensitivity measures: i) the Elementary Effect for screening the parameters, and ii) the variance decomposition method for calculating the Sobol indices that quantify both the main and interaction effects. The application of the proposed approach is illustrated with an industrial application with the goal of optimizing a drilling process using a Gaussian laser beam.

  14. An integrated approach for the knowledge discovery in computer simulation models with a multi-dimensional parameter space

    Energy Technology Data Exchange (ETDEWEB)

    Khawli, Toufik Al; Eppelt, Urs; Hermanns, Torsten [RWTH Aachen University, Chair for Nonlinear Dynamics, Steinbachstr. 15, 52047 Aachen (Germany); Gebhardt, Sascha [RWTH Aachen University, Virtual Reality Group, IT Center, Seffenter Weg 23, 52074 Aachen (Germany); Kuhlen, Torsten [Forschungszentrum Jülich GmbH, Institute for Advanced Simulation (IAS), Jülich Supercomputing Centre (JSC), Wilhelm-Johnen-Straße, 52425 Jülich (Germany); Schulz, Wolfgang [Fraunhofer, ILT Laser Technology, Steinbachstr. 15, 52047 Aachen (Germany)

    2016-06-08

    In production industries, parameter identification, sensitivity analysis and multi-dimensional visualization are vital steps in the planning process for achieving optimal designs and gaining valuable information. Sensitivity analysis and visualization can help in identifying the most-influential parameters and quantify their contribution to the model output, reduce the model complexity, and enhance the understanding of the model behavior. Typically, this requires a large number of simulations, which can be both very expensive and time consuming when the simulation models are numerically complex and the number of parameter inputs increases. There are three main constituent parts in this work. The first part is to substitute the numerical, physical model by an accurate surrogate model, the so-called metamodel. The second part includes a multi-dimensional visualization approach for the visual exploration of metamodels. In the third part, the metamodel is used to provide the two global sensitivity measures: i) the Elementary Effect for screening the parameters, and ii) the variance decomposition method for calculating the Sobol indices that quantify both the main and interaction effects. The application of the proposed approach is illustrated with an industrial application with the goal of optimizing a drilling process using a Gaussian laser beam.

  15. Petroleum potential of the northern Sinu-San Jacinto Basin, Colombia: an integrated petroleum system and basin modeling approach

    Energy Technology Data Exchange (ETDEWEB)

    Nino, Christian H.; Goncalves, Felix T.T.; Bedregal, Ricardo P. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE). Lab. de Modelagem de Bacias (LAB2M); Azevedo, Debora A. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica; Landau, Luis [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE). Lab. de Metodos Computacionais em Engenharia (LAMCE)

    2004-07-01

    The northern Sinu-San Jacinto basin, located in the northwestern corner of South America (Colombia), belongs to the accretionary prism that resulted from the collision and subduction of the Caribbean plate under the South America plate. Despite all the previous exploratory efforts, solely a few small sub-commercial oil and gas accumulation have been found up to now. The geological and geochemical information acquired by different companies during the lasts decades was integrated with new geochemical analysis and basin modeling to characterize the petroleum systems, to reconstruct the hydrocarbon charge history in the study area and to better assess the exploratory risk. (author)

  16. Monitoring and Counteracting Functional Deterioration in Parkinson’s Disease: A Multilevel Integrative Approach in a Primate Model System

    Science.gov (United States)

    2007-09-01

    Philippens CONTRACTING ORGANIZATION: TNO Defense Safety and Security RYSWYK 2288GJ REPORT DATE: September 2007...approach in a primate model system 5b. GRANT NUMBER W81XWH-05-1-0517 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Philippens , Ingrid, H.; Verhave... Philippens , 2006) it has generally accepted to have a well tolerated profile in human users (Bensimon et al., 1994). The ‘drowsiness’ does seem to have

  17. Addressing uncertainties in the ERICA Integrated Approach

    International Nuclear Information System (INIS)

    Oughton, D.H.; Agueero, A.; Avila, R.; Brown, J.E.; Copplestone, D.; Gilek, M.

    2008-01-01

    Like any complex environmental problem, ecological risk assessment of the impacts of ionising radiation is confounded by uncertainty. At all stages, from problem formulation through to risk characterisation, the assessment is dependent on models, scenarios, assumptions and extrapolations. These include technical uncertainties related to the data used, conceptual uncertainties associated with models and scenarios, as well as social uncertainties such as economic impacts, the interpretation of legislation, and the acceptability of the assessment results to stakeholders. The ERICA Integrated Approach has been developed to allow an assessment of the risks of ionising radiation, and includes a number of methods that are intended to make the uncertainties and assumptions inherent in the assessment more transparent to users and stakeholders. Throughout its development, ERICA has recommended that assessors deal openly with the deeper dimensions of uncertainty and acknowledge that uncertainty is intrinsic to complex systems. Since the tool is based on a tiered approach, the approaches to dealing with uncertainty vary between the tiers, ranging from a simple, but highly conservative screening to a full probabilistic risk assessment including sensitivity analysis. This paper gives on overview of types of uncertainty that are manifest in ecological risk assessment and the ERICA Integrated Approach to dealing with some of these uncertainties

  18. Marital Counseling: An Integrated Brief Therapy Approach.

    Science.gov (United States)

    Magnuson, Sandy; Norem, Ken

    1998-01-01

    Addresses advantages of, and potential pitfalls in, integrated approaches to marital counseling. Presents a sequential approach in which various approaches to marital counseling are integrated without jeopardizing internal consistency and uniformity in treatment. Offers precounseling considerations and procedures for a five-session series.…

  19. Modeling integrated biomass gasification business concepts

    Science.gov (United States)

    Peter J. Ince; Ted Bilek; Mark A. Dietenberger

    2011-01-01

    Biomass gasification is an approach to producing energy and/or biofuels that could be integrated into existing forest product production facilities, particularly at pulp mills. Existing process heat and power loads tend to favor integration at existing pulp mills. This paper describes a generic modeling system for evaluating integrated biomass gasification business...

  20. An Integrated Modeling and Experimental Approach to Study the Influence of Environmental Nutrients on Biofilm Formation of Pseudomonas aeruginosa.

    Science.gov (United States)

    Xu, Zhaobin; Islam, Sabina; Wood, Thomas K; Huang, Zuyi

    2015-01-01

    The availability of nutrient components in the environment was identified as a critical regulator of virulence and biofilm formation in Pseudomonas aeruginosa. This work proposes the first systems-biology approach to quantify microbial biofilm formation upon the change of nutrient availability in the environment. Specifically, the change of fluxes of metabolic reactions that were positively associated with P. aeruginosa biofilm formation was used to monitor the trend for P. aeruginosa to form a biofilm. The uptake rates of nutrient components were changed according to the change of the nutrient availability. We found that adding each of the eleven amino acids (Arg, Tyr, Phe, His, Iso, Orn, Pro, Glu, Leu, Val, and Asp) to minimal medium promoted P. aeruginosa biofilm formation. Both modeling and experimental approaches were further developed to quantify P. aeruginosa biofilm formation for four different availability levels for each of the three ions that include ferrous ions, sulfate, and phosphate. The developed modeling approach correctly predicted the amount of biofilm formation. By comparing reaction flux change upon the change of nutrient concentrations, metabolic reactions used by P. aeruginosa to regulate its biofilm formation are mainly involved in arginine metabolism, glutamate production, magnesium transport, acetate metabolism, and the TCA cycle.

  1. An Integrated Modeling and Experimental Approach to Study the Influence of Environmental Nutrients on Biofilm Formation of Pseudomonas aeruginosa

    Science.gov (United States)

    Xu, Zhaobin; Islam, Sabina; Wood, Thomas K.; Huang, Zuyi

    2015-01-01

    The availability of nutrient components in the environment was identified as a critical regulator of virulence and biofilm formation in Pseudomonas aeruginosa. This work proposes the first systems-biology approach to quantify microbial biofilm formation upon the change of nutrient availability in the environment. Specifically, the change of fluxes of metabolic reactions that were positively associated with P. aeruginosa biofilm formation was used to monitor the trend for P. aeruginosa to form a biofilm. The uptake rates of nutrient components were changed according to the change of the nutrient availability. We found that adding each of the eleven amino acids (Arg, Tyr, Phe, His, Iso, Orn, Pro, Glu, Leu, Val, and Asp) to minimal medium promoted P. aeruginosa biofilm formation. Both modeling and experimental approaches were further developed to quantify P. aeruginosa biofilm formation for four different availability levels for each of the three ions that include ferrous ions, sulfate, and phosphate. The developed modeling approach correctly predicted the amount of biofilm formation. By comparing reaction flux change upon the change of nutrient concentrations, metabolic reactions used by P. aeruginosa to regulate its biofilm formation are mainly involved in arginine metabolism, glutamate production, magnesium transport, acetate metabolism, and the TCA cycle. PMID:25954752

  2. From integrated control to integrated farming, an experimental approach

    NARCIS (Netherlands)

    Vereijken, P.H.

    1989-01-01

    Integrated control or integrated pest management (IPM), as envisaged originally, is not being practised to any large extent in arable farming, notwithstanding considerable research efforts. The reasons for this are discussed. A more basic approach called integrated farming is suggested. Preliminary

  3. Clayey cap-rocks reactivity in presence of CO2 in deep geological storage conditions: experimentation/modeling integrated approach

    International Nuclear Information System (INIS)

    Credoz, A.

    2009-10-01

    CO 2 capture, transport and geological storage is one of the main solutions considered in the short and medium term to reduce CO 2 and others greenhouse gases emissions towards the atmosphere, by storing CO 2 in deeper geological reservoirs during 100 to 10 000 years. This Ph-D study offers a multi-scale vision of complex clayey cap-rocks reactivity and evolution. These formations are identified for the CO 2 containment and sealing into the reservoir. From the experimental scale on purified clay minerals to integrative modeling at high space and time scales, the strategy developed allowed identifying the main geochemical processes, to check the good agreement between experiment and modeling, and to lay emphasis the operational impacts on long-term cap-rocks integrity. Carbonated cements alteration is likely to open cap-rock porosity and to create preferential reactive pathway for reactive fluid flow. Besides, this could alter the cap-rock structure and the global geo-mechanic properties. Clay minerals alteration, including the illitization process, reduces the clay fraction volume but considerably limits the porosity increase. The illitization process in acidic conditions determined experimentally and by modeling at low and high scale, is coupled with silica precipitation. The final porosity increase control results of these two reactive processes balance. By a fundamental side, this study reveals new kinetic parameters of clay minerals and highlights new structural transformations. By an operational side, this study contributes to the acquisition of qualitative data (long-term reactive pathways of clayey cap-rocks, coupled reactivity carbonates/clays) and quantitative data (CO 2 penetration distance into the cap-rock) to partly answer to the performance and safety assessment CO 2 capture and geological storage. (author)

  4. Qualitative modelling for the Caeté Mangrove Estuary (North Brazil): a preliminary approach to an integrated eco-social analysis

    Science.gov (United States)

    Ortiz, Marco; Wolff, Matthias

    2004-10-01

    The sustainability of different integrated management regimes for the mangrove ecosystem of the Caeté Estuary (North Brazil) were assessed using a holistic theoretical framework. As a way to demonstrate that the behaviour and trajectory of complex whole systems are not epiphenomenal to the properties of the small parts, a set of conceptual models from more reductionistic to more holistic were enunciated. These models integrate the scientific information published until present for this mangrove ecosystem. The sustainability of different management scenarios (forestry and fishery) was assessed. Since the exploitation of mangrove trees is not allowed according Brazilian laws, the forestry was only included for simulation purposes. The model simulations revealed that sustainability predictions of reductionistic models should not be extrapolated into holistic approaches. Forestry and fishery activities seem to be sustainable only if they are self-damped. The exploitation of the two mangrove species Rhizophora mangle and Avicenia germinans does not appear to be sustainable, thus a rotation harvest is recommended. A similar conclusion holds for the exploitation of invertebrate species. Our results suggest that more studies should be focused on the estimation of maximum sustainable yield based on a multispecies approach. Any reference to holistic sustainability based on reductionistic approaches may distort our understanding of the natural complex ecosystems.

  5. Beyond long memory in heart rate variability: An approach based on fractionally integrated autoregressive moving average time series models with conditional heteroscedasticity

    Science.gov (United States)

    Leite, Argentina; Paula Rocha, Ana; Eduarda Silva, Maria

    2013-06-01

    Heart Rate Variability (HRV) series exhibit long memory and time-varying conditional variance. This work considers the Fractionally Integrated AutoRegressive Moving Average (ARFIMA) models with Generalized AutoRegressive Conditional Heteroscedastic (GARCH) errors. ARFIMA-GARCH models may be used to capture and remove long memory and estimate the conditional volatility in 24 h HRV recordings. The ARFIMA-GARCH approach is applied to fifteen long term HRV series available at Physionet, leading to the discrimination among normal individuals, heart failure patients, and patients with atrial fibrillation.

  6. Challenges in integrative approaches to modelling the marine ecosystems of the North Atlantic: Physics to fish and coasts to ocean

    DEFF Research Database (Denmark)

    Holt, Jason; Icarus Allen, J.; Anderson, Thomas R.

    2014-01-01

    It has long been recognised that there are strong interactions and feedbacks between climate, upper ocean biogeochemistry and marine food webs, and also that food web structure and phytoplankton community distribution are important determinants of variability in carbon production and export from...... for quantitative tools to support ecosystem-based management initiatives. The purpose of this paper is to review approaches to the modelling of marine ecosystems with a focus on the North Atlantic Ocean and its adjacent shelf seas, and to highlight the challenges they face and suggest ways forward. We consider...

  7. Evaluation and prediction of oil biodegradation: a novel approach integrating geochemical and basin modeling techniques in offshore Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Baudino, Roger [YPF S.A. (Argentina); Santos, Glauce Figueiredo dos; Losilla, Carlos; Cabrera, Ricardo; Loncarich, Ariel; Gavarrino, Alejandro [RepsolYPF do Brasil, Sao Paulo, SP (Brazil)

    2008-07-01

    Oil fields accounting for a large portion of the world reserves are severely affected by biological degradation. In Brazil, giant fields of the Campos Basin are producing biodegraded oils with widely variable fluid characteristics (10 to 40 deg API) and no apparent logical distribution nor predictability. Modern geochemical techniques allow defining the level of biodegradation. When original (non-degraded) oil samples and other with varying degradation level are available it might be possible to define a distribution trend and to relate it to present day geological factors such as temperature and reservoir geometry. However, other critical factors must be taken into account. But most of all, it is fundamental to have a vision in time of their evolution. This can only be achieved through 3D Basin Models coupled with modern visualization tools. The multi-disciplinary work-flow described here integrates three-dimensional numerical simulations with modern geochemical analyses. (author)

  8. TU-G-210-02: TRANS-FUSIMO - An Integrative Approach to Model-Based Treatment Planning of Liver FUS

    International Nuclear Information System (INIS)

    Preusser, T.

    2015-01-01

    Modeling can play a vital role in predicting, optimizing and analyzing the results of therapeutic ultrasound treatments. Simulating the propagating acoustic beam in various targeted regions of the body allows for the prediction of the resulting power deposition and temperature profiles. In this session we will apply various modeling approaches to breast, abdominal organ and brain treatments. Of particular interest is the effectiveness of procedures for correcting for phase aberrations caused by intervening irregular tissues, such as the skull in transcranial applications or inhomogeneous breast tissues. Also described are methods to compensate for motion in targeted abdominal organs such as the liver or kidney. Douglas Christensen – Modeling for Breast and Brain HIFU Treatment Planning Tobias Preusser – TRANS-FUSIMO – An Integrative Approach to Model-Based Treatment Planning of Liver FUS Tobias Preusser – TRANS-FUSIMO – An Integrative Approach to Model-Based Treatment Planning of Liver FUS Learning Objectives: Understand the role of acoustic beam modeling for predicting the effectiveness of therapeutic ultrasound treatments. Apply acoustic modeling to specific breast, liver, kidney and transcranial anatomies. Determine how to obtain appropriate acoustic modeling parameters from clinical images. Understand the separate role of absorption and scattering in energy delivery to tissues. See how organ motion can be compensated for in ultrasound therapies. Compare simulated data with clinical temperature measurements in transcranial applications. Supported by NIH R01 HL172787 and R01 EB013433 (DC); EU Seventh Framework Programme (FP7/2007-2013) under 270186 (FUSIMO) and 611889 (TRANS-FUSIMO)(TP); and P01 CA159992, GE, FUSF and InSightec (UV)

  9. TU-G-210-02: TRANS-FUSIMO - An Integrative Approach to Model-Based Treatment Planning of Liver FUS

    Energy Technology Data Exchange (ETDEWEB)

    Preusser, T. [Fraunhofer MEVIS & Jacobs University (Germany)

    2015-06-15

    Modeling can play a vital role in predicting, optimizing and analyzing the results of therapeutic ultrasound treatments. Simulating the propagating acoustic beam in various targeted regions of the body allows for the prediction of the resulting power deposition and temperature profiles. In this session we will apply various modeling approaches to breast, abdominal organ and brain treatments. Of particular interest is the effectiveness of procedures for correcting for phase aberrations caused by intervening irregular tissues, such as the skull in transcranial applications or inhomogeneous breast tissues. Also described are methods to compensate for motion in targeted abdominal organs such as the liver or kidney. Douglas Christensen – Modeling for Breast and Brain HIFU Treatment Planning Tobias Preusser – TRANS-FUSIMO – An Integrative Approach to Model-Based Treatment Planning of Liver FUS Tobias Preusser – TRANS-FUSIMO – An Integrative Approach to Model-Based Treatment Planning of Liver FUS Learning Objectives: Understand the role of acoustic beam modeling for predicting the effectiveness of therapeutic ultrasound treatments. Apply acoustic modeling to specific breast, liver, kidney and transcranial anatomies. Determine how to obtain appropriate acoustic modeling parameters from clinical images. Understand the separate role of absorption and scattering in energy delivery to tissues. See how organ motion can be compensated for in ultrasound therapies. Compare simulated data with clinical temperature measurements in transcranial applications. Supported by NIH R01 HL172787 and R01 EB013433 (DC); EU Seventh Framework Programme (FP7/2007-2013) under 270186 (FUSIMO) and 611889 (TRANS-FUSIMO)(TP); and P01 CA159992, GE, FUSF and InSightec (UV)

  10. An Agent-Based Modeling Approach to Integrate Tsunami Science, Human Behavior, and Unplanned Network Disruptions for Nearfield Tsunami Evacuation

    Science.gov (United States)

    Cox, D. T.; Wang, H.; Cramer, L.; Mostafizi, A.; Park, H.

    2016-12-01

    For the Cascadia Subduction Zone (CSZ) and other extreme near-field tsunami hazards, coastal residents and tourist must evacuate within 15 to 30 minutes immediately following intense ground-shaking and will be confronted with an array of choices: Should I evacuate on foot or by car? Alone, or find friends and family first? Head for high ground far away, or seek shelter a nearby building? How will the roads and bridges be affected by the preceding earthquake? In this project, we integrate the disciplines of tsunami inundation science, sociology, and civil engineering to investigate how decision-making by individual evacuees with respect to milling time, mode choice, and destination affects their life safety. We use an Agent-Based Model (ABM) to create credible scenarios for near-field tsunami evacuation. The ABM integrates (1) the time-dependent tsunami inundation computed separately using NOAA's ComMIT/MOST model, (2) population layers to account for variations in population density of residents and tourist, (3) evacuation route network including roads, bridges and foot paths for multi-modal transportation, and (4) evacuation destinations for horizontal and vertical evacuation. For this project, we apply the ABM at two locations: the city Seaside, OR, and South Beach State Park in Newport, OR. In the Seaside scenario, we show how unplanned network disruption - e.g. the partial or total failure of bridges due to the preceding earthquake - will affect life safety and show how the ABM can be used to provide retrofit strategies. For South Beach, we show how alternative routing can have a substantial impact on life safety. The ABM shows results that are initially counterintuitive. For the Seaside example, resource allocation for bridge retrofit favors investments in nodes and links not necessarily in close proximity to population centers. For the South Beach example, the routes which provide for the lowest risk (maximum life safety) are not always those with the

  11. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.

    Science.gov (United States)

    Sekiya, Michiko; Wang, Minghui; Fujisaki, Naoki; Sakakibara, Yasufumi; Quan, Xiuming; Ehrlich, Michelle E; De Jager, Philip L; Bennett, David A; Schadt, Eric E; Gandy, Sam; Ando, Kanae; Zhang, Bin; Iijima, Koichi M

    2018-03-29

    Cerebral amyloidosis, neuroinflammation, and tauopathy are key features of Alzheimer's disease (AD), but interactions among these features remain poorly understood. Our previous multiscale molecular network models of AD revealed TYROBP as a key driver of an immune- and microglia-specific network that was robustly associated with AD pathophysiology. Recent genetic studies of AD further identified pathogenic mutations in both TREM2 and TYROBP. In this study, we systematically examined molecular and pathological interactions among Aβ, tau, TREM2, and TYROBP by integrating signatures from transgenic Drosophila models of AD and transcriptome-wide gene co-expression networks from two human AD cohorts. Glial expression of TREM2/TYROBP exacerbated tau-mediated neurodegeneration and synergistically affected pathways underlying late-onset AD pathology, while neuronal Aβ42 and glial TREM2/TYROBP synergistically altered expression of the genes in synaptic function and immune modules in AD. The comprehensive pathological and molecular data generated through this study strongly validate the causal role of TREM2/TYROBP in driving molecular networks in AD and AD-related phenotypes in flies.

  12. A Langmuir-Hinshelwood approach to the kinetic modelling of catalytic ammonia decomposition in an integral reactor.

    Science.gov (United States)

    Armenise, S; García-Bordejé, E; Valverde, J L; Romeo, E; Monzón, A

    2013-08-07

    The increasing interest in ammonia decomposition is due to the fact that this compound can be used advantageously as a hydrogen carrier, allowing the development of single-step hydrogen generation systems. With the aim of developing efficient reactors for ammonia decomposition, e.g. for fuel cell applications, it is imperative to investigate the kinetics and reaction mechanism in depth. The main goal of this work is to develop reliable kinetic models that are able to predict the performance obtained using integral reactors, e.g. monoliths. In this case, an almost complete NH3 conversion is obtained, with a high H2 concentration at the exit of the reactor. The operating conditions, mainly the gas composition, are very different along the reactor. In addition, the temperatures needed to attain such large conversions are usually high. The kinetic models developed in this contribution are based on the Langmuir isotherm, considering that all the adsorbed species can be kinetically relevant, that the slow step or steps can be partially reversible, and that the surface can be considered as energetically uniform, i.e. ideal. Among other conclusions, the results obtained indicate that the variable kinetic orders and apparent activation energies frequently reported in the literature can be direct consequences of the data analysis and can therefore also be explained without considering any change in the controlling step with the reaction temperature or in the hydrogen or ammonia concentration.

  13. An integrated approach to flood hazard assessment on alluvial fans using numerical modeling, field mapping, and remote sensing

    Science.gov (United States)

    Pelletier, J.D.; Mayer, L.; Pearthree, P.A.; House, P.K.; Demsey, K.A.; Klawon, J.K.; Vincent, K.R.

    2005-01-01

    Millions of people in the western United States live near the dynamic, distributary channel networks of alluvial fans where flood behavior is complex and poorly constrained. Here we test a new comprehensive approach to alluvial-fan flood hazard assessment that uses four complementary methods: two-dimensional raster-based hydraulic modeling, satellite-image change detection, fieldbased mapping of recent flood inundation, and surficial geologic mapping. Each of these methods provides spatial detail lacking in the standard method and each provides critical information for a comprehensive assessment. Our numerical model simultaneously solves the continuity equation and Manning's equation (Chow, 1959) using an implicit numerical method. It provides a robust numerical tool for predicting flood flows using the large, high-resolution Digital Elevation Models (DEMs) necessary to resolve the numerous small channels on the typical alluvial fan. Inundation extents and flow depths of historic floods can be reconstructed with the numerical model and validated against field- and satellite-based flood maps. A probabilistic flood hazard map can also be constructed by modeling multiple flood events with a range of specified discharges. This map can be used in conjunction with a surficial geologic map to further refine floodplain delineation on fans. To test the accuracy of the numerical model, we compared model predictions of flood inundation and flow depths against field- and satellite-based flood maps for two recent extreme events on the southern Tortolita and Harquahala piedmonts in Arizona. Model predictions match the field- and satellite-based maps closely. Probabilistic flood hazard maps based on the 10 yr, 100 yr, and maximum floods were also constructed for the study areas using stream gage records and paleoflood deposits. The resulting maps predict spatially complex flood hazards that strongly reflect small-scale topography and are consistent with surficial geology. In

  14. Integrated modeling: a look back

    Science.gov (United States)

    Briggs, Clark

    2015-09-01

    This paper discusses applications and implementation approaches used for integrated modeling of structural systems with optics over the past 30 years. While much of the development work focused on control system design, significant contributions were made in system modeling and computer-aided design (CAD) environments. Early work appended handmade line-of-sight models to traditional finite element models, such as the optical spacecraft concept from the ACOSS program. The IDEAS2 computational environment built in support of Space Station collected a wider variety of existing tools around a parametric database. Later, IMOS supported interferometer and large telescope mission studies at JPL with MATLAB modeling of structural dynamics, thermal analysis, and geometric optics. IMOS's predecessor was a simple FORTRAN command line interpreter for LQG controller design with additional functions that built state-space finite element models. Specialized language systems such as CAESY were formulated and prototyped to provide more complex object-oriented functions suited to control-structure interaction. A more recent example of optical modeling directly in mechanical CAD is used to illustrate possible future directions. While the value of directly posing the optical metric in system dynamics terms is well understood today, the potential payoff is illustrated briefly via project-based examples. It is quite likely that integrated structure thermal optical performance (STOP) modeling could be accomplished in a commercial off-the-shelf (COTS) tool set. The work flow could be adopted, for example, by a team developing a small high-performance optical or radio frequency (RF) instrument.

  15. Environmental impacts of land use and land cover change in the Zhujiang Delta, China: An analysis using an integrated GIS, remote sensing, and spatial modeling approach

    Science.gov (United States)

    Weng, Qihao

    This dissertation attempts to apply an integrated approach of remote sensing, GIS, and spatial modeling for environmental studies. The feasibility, advantages, and disadvantages of this integrated approach are investigated through land use and land cover change modeling, environmental impact analysis, and stochastic analysis. By applying this approach to the Zhujiang Delta, this dissertation also attempts to examine the environmental implications of China's economic reform policies. This study finds that the integration among remote sensing, GIS, and spatial modeling is necessary and effective for solving many environmental problems. Integration by exchanging data files among these three elements is feasible in spite of its time-consuming and error-prone nature. Satellite remote sensing collects multispectral, multiresolution, and multitemporal data, and turns them into information valuable for environmental studies. GIS technology provides a flexible environment for entering, analyzing, and displaying digital data from various sources, and can incorporate socioeconomic data necessary for environmental problem solving. However, GIS needs to be further integrated with various spatial modeling techniques, because the current generation of GIS lacks the necessary predictive and analytical capabilities. The case study in the Zhujiang Delta examines its land use and land cover changes and environmental impacts between 1989 and 1997. Results show, first, that urban/built-up areas and horticulture farms have increased, while cropland has decreased. These changes are related to industrial and agricultural development as well as population growth during the period. The spatial process of urban expansion shows an intimate relationship with the distance from major roads and from the geometric center of a city. Second, urban land development tends to bring down greenness, raise surface radiant temperatures, and increase surface runoff. In contrast, horticulture farms promote

  16. Integrated Assessment Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Edmonds, James A.; Calvin, Katherine V.; Clarke, Leon E.; Janetos, Anthony C.; Kim, Son H.; Wise, Marshall A.; McJeon, Haewon C.

    2012-10-31

    This paper discusses the role of Integrated Assessment models (IAMs) in climate change research. IAMs are an interdisciplinary research platform, which constitutes a consistent scientific framework in which the large-scale interactions between human and natural Earth systems can be examined. In so doing, IAMs provide insights that would otherwise be unavailable from traditional single-discipline research. By providing a broader view of the issue, IAMs constitute an important tool for decision support. IAMs are also a home of human Earth system research and provide natural Earth system scientists information about the nature of human intervention in global biogeophysical and geochemical processes.

  17. Toward a quantitative approach to migrants integration

    Science.gov (United States)

    Barra, A.; Contucci, P.

    2010-03-01

    Migration phenomena and all the related issues, like integration of different social groups, are intrinsically complex problems since they strongly depend on several competitive mechanisms as economic factors, cultural differences and many others. By identifying a few essential assumptions, and using the statistical mechanics of complex systems, we propose a novel quantitative approach that provides a minimal theory for those phenomena. We show that the competitive interactions in decision making between a population of N host citizens and P immigrants, a bi-partite spin-glass, give rise to a social consciousness inside the host community in the sense of the associative memory of neural networks. The theory leads to a natural quantitative definition of migrant's "integration" inside the community. From the technical point of view this minimal picture assumes, as control parameters, only general notions like the strength of the random interactions, the ratio between the sizes of the two parties and the cultural influence. Few steps forward, toward more refined models, which include a digression on the kind of the felt experiences and some structure on the random interaction topology (as dilution to avoid the plain mean-field approach) and correlations of experiences felt between the two parties (biasing the distribution of the coupling) are discussed at the end, where we show the robustness of our approach.

  18. A genetic predictive model for canine hip dysplasia: integration of Genome Wide Association Study (GWAS and candidate gene approaches.

    Directory of Open Access Journals (Sweden)

    Nerea Bartolomé

    Full Text Available Canine hip dysplasia is one of the most prevalent developmental orthopedic diseases in dogs worldwide. Unfortunately, the success of eradication programs against this disease based on radiographic diagnosis is low. Adding the use of diagnostic genetic tools to the current phenotype-based approach might be beneficial. The aim of this study was to develop a genetic prognostic test for early diagnosis of hip dysplasia in Labrador Retrievers. To develop our DNA test, 775 Labrador Retrievers were recruited. For each dog, a blood sample and a ventrodorsal hip radiograph were taken. Dogs were divided into two groups according to their FCI hip score: control (A/B and case (D/E. C dogs were not included in the sample. Genetic characterization combining a GWAS and a candidate gene strategy using SNPs allowed a case-control population association study. A mathematical model which included 7 SNPs was developed using logistic regression. The model showed a good accuracy (Area under the ROC curve = 0.85 and was validated in an independent population of 114 dogs. This prognostic genetic test represents a useful tool for choosing the most appropriate therapeutic approach once genetic predisposition to hip dysplasia is known. Therefore, it allows a more individualized management of the disease. It is also applicable during genetic selection processes, since breeders can benefit from the information given by this test as soon as a blood sample can be collected, and act accordingly. In the authors' opinion, a shift towards genomic screening might importantly contribute to reducing canine hip dysplasia in the future. In conclusion, based on genetic and radiographic information from Labrador Retrievers with hip dysplasia, we developed an accurate predictive genetic test for early diagnosis of hip dysplasia in Labrador Retrievers. However, further research is warranted in order to evaluate the validity of this genetic test in other dog breeds.

  19. Integrated astrophysical modeling

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, T. A.; Eastman, R. G.; Dubois, P.; Eltgroth, P. G.; Gentile, N.; Jedamzik, K.; Wilson, J. R.

    1997-06-03

    In this project, we have developed prototype techniques for defining and extending a variety of astrophysical modeling capabilities, including those involving multidimensional hydrodynamics, complex transport, and flexibly-coupled equation-of state and nuclear reaction networks. As expected, this project is having both near-term payoffs in understanding complex astrophysical phenomena, as well as significant spin-offs in terms of people and ideas to related ASCI code efforts. Most of our work in the first part of this project was focused on the modularization, extension, and initial integration of 4 previously separate and incommensurate codes: the stellar evolution/explosion code KEPLER; the non-LTE spectral line transport code, EDDINGTON, used for modeling supernovae spectra; the 3-D smooth particle hydro code, PIP; and the discontinuous-finite-element, 3D hydro module from the lCF3D code.

  20. Integrated Environmental Assessment Modelling

    Energy Technology Data Exchange (ETDEWEB)

    Guardanz, R.; Gimeno, B. S.; Bermejo, V.; Elvira, S.; Martin, F.; Palacios, M.; Rodriguez, E.; Donaire, I. [Ciemat, Madrid (Spain)

    2000-07-01

    This report describes the results of the Spanish participation in the project Coupling CORINAIR data to cost-effect emission reduction strategies based on critical threshold. (EU/LIFE97/ENV/FIN/336). The subproject has focused on three tasks. Develop tools to improve knowledge on the spatial and temporal details of emissions of air pollutants in Spain. Exploit existing experimental information on plant response to air pollutants in temperate ecosystem and Integrate these findings in a modelling framework that can asses with more accuracy the impact of air pollutants to temperate ecosystems. The results obtained during the execution of this project have significantly improved the models of the impact of alternative emission control strategies on ecosystems and crops in the Iberian Peninsula. (Author) 375 refs.

  1. A multi-modal network approach to model public transport accessibility impacts of bicycle-train integration policies

    NARCIS (Netherlands)

    Geurs, Karst Teunis; La Paix Puello, Lissy Cesarina; van Weperen, Sander

    2016-01-01

    In the Netherlands, the bicycle plays an important in station access and, to a lesser extent, in station egress. There is however fairly little knowledge in the potential effects of bicycle-train integration policies. The aim of this paper is to examine the impacts of bicycle-train integration

  2. Integrating Individual and Systems Approaches: Strategic-Behavioral Therapy.

    Science.gov (United States)

    Duncan, Barry L.; Parks, M. Bernadine

    1988-01-01

    Presents a brief model which integrates an individual, cognitive-behavioral approach with a strategic approach to therapy, at both pragmatic and theoretical levels. Justifies the selective use of behavioral frames in strategic therapy in this Strategic-Behavioral model, and offers guidelines for their selective application. Presents and discusses…

  3. Thermodynamics and statistical mechanics an integrated approach

    CERN Document Server

    Shell, M Scott

    2015-01-01

    Learn classical thermodynamics alongside statistical mechanics with this fresh approach to the subjects. Molecular and macroscopic principles are explained in an integrated, side-by-side manner to give students a deep, intuitive understanding of thermodynamics and equip them to tackle future research topics that focus on the nanoscale. Entropy is introduced from the get-go, providing a clear explanation of how the classical laws connect to the molecular principles, and closing the gap between the atomic world and thermodynamics. Notation is streamlined throughout, with a focus on general concepts and simple models, for building basic physical intuition and gaining confidence in problem analysis and model development. Well over 400 guided end-of-chapter problems are included, addressing conceptual, fundamental, and applied skill sets. Numerous worked examples are also provided together with handy shaded boxes to emphasize key concepts, making this the complete teaching package for students in chemical engineer...

  4. The dynamical systems approach to numerical integration

    Science.gov (United States)

    Wisdom, Jack

    2018-03-01

    The dynamical systems approach to numerical integration is reviewed and extended. The new method is compared to some alternative methods based on the Lie series approach. The test problem is the motion of the outer planets. The algorithms developed using the dynamical systems approach perform well.

  5. An integrated approach coupling physically based models and probabilistic method to assess quantitatively landslide susceptibility at different scale: application to different geomorphological environments

    Science.gov (United States)

    Vandromme, Rosalie; Thiéry, Yannick; Sedan, Olivier; Bernardie, Séverine

    2016-04-01

    Landslide hazard assessment is the estimation of a target area where landslides of a particular type, volume, runout and intensity may occur within a given period. The first step to analyze landslide hazard consists in assessing the spatial and temporal failure probability (when the information is available, i.e. susceptibility assessment). Two types of approach are generally recommended to achieve this goal: (i) qualitative approach (i.e. inventory based methods and knowledge data driven methods) and (ii) quantitative approach (i.e. data-driven methods or deterministic physically based methods). Among quantitative approaches, deterministic physically based methods (PBM) are generally used at local and/or site-specific scales (1:5,000-1:25,000 and >1:5,000, respectively). The main advantage of these methods is the calculation of probability of failure (safety factor) following some specific environmental conditions. For some models it is possible to integrate the land-uses and climatic change. At the opposite, major drawbacks are the large amounts of reliable and detailed data (especially materials type, their thickness and the geotechnical parameters heterogeneity over a large area) and the fact that only shallow landslides are taking into account. This is why they are often used at site-specific scales (> 1:5,000). Thus, to take into account (i) materials' heterogeneity , (ii) spatial variation of physical parameters, (iii) different landslide types, the French Geological Survey (i.e. BRGM) has developed a physically based model (PBM) implemented in a GIS environment. This PBM couples a global hydrological model (GARDENIA®) including a transient unsaturated/saturated hydrological component with a physically based model computing the stability of slopes (ALICE®, Assessment of Landslides Induced by Climatic Events) based on the Morgenstern-Price method for any slip surface. The variability of mechanical parameters is handled by Monte Carlo approach. The

  6. The relative impact of climate change mitigation policies and socioeconomic drivers on water scarcity - An integrated assessment modeling approach

    Science.gov (United States)

    Hejazi, M. I.; Edmonds, J. A.; Clarke, L. E.; Kyle, P.; Davies, E. G.; Chaturvedi, V.; Patel, P.; Eom, J.; Wise, M.; Kim, S.; Calvin, K. V.; Moss, R. H.

    2012-12-01

    We investigate the relative effects of climate emission mitigation policies and socioeconomic drivers on water scarcity conditions over the 21st century both globally and regionally, by estimating both water availability and demand within a technologically-detailed global integrated assessment model of energy, agriculture, and climate change - the Global Change Assessment Model (GCAM). We first develop a global gridded monthly hydrologic model that reproduces historical streamflow observations and simulates the future availability of freshwater under both a changing climate and an evolving landscape, and incorporate this model into GCAM. We then develop and incorporate technologically oriented representations of water demands for the agricultural (irrigation and livestock), energy (electricity generation, primary energy production and processing), industrial (manufacturing and mining), and municipal sectors. The energy, industrial, and municipal sectors are represented in fourteen geopolitical regions, with the agricultural sector further disaggregated into as many as eighteen agro-ecological zones (AEZs) within each region. To perform the water scarcity analysis at the grid scale, the global water demands for the six demand sectors are spatially downscaled to 0.5 o x 0.5o resolution to match the scale of GWAM. The water scarcity index (WSI) compares total water demand to the total amount of renewable water available, and defines extreme water scarcity in any region as demand greater than 40% of total water availability. Using a reference scenario (i.e., no climate change mitigation policy) with radiative forcing reaching 8.8 W/m2 by 2095 and a global population of 14 billion, global annual water demand grows from about 9% of total annual renewable freshwater in 2005 to about 32% by 2095. This results in almost half of the world population living under extreme water scarcity by the end of the 21st century. Regionally, the demands for water exceed the total

  7. Introducing a model of cardiovascular prevention in Nairobi's slums by integrating a public health and private-sector approach: the SCALE-UP study

    Directory of Open Access Journals (Sweden)

    Steven van de Vijver

    2013-10-01

    Full Text Available Introduction: Cardiovascular disease (CVD is a leading cause of death in sub-Saharan Africa (SSA, with annual deaths expected to increase to 2 million by 2030. Currently, most national health systems in SSA are not adequately prepared for this epidemic. This is especially so in slum settlements where access to formal healthcare and resources is limited. Objective: To develop and introduce a model of cardiovascular prevention in the slums of Nairobi by integrating public health and private sector approaches. Study design: Two non-profit organizations that conduct public health research, Amsterdam Institute for Global Health and Development (AIGHD and African Population and Health Research Center (APHRC, collaborated with private-sector Boston Consulting Group (BCG to develop a service delivery package for CVD prevention in slum settings. A theoretic model was designed based on the integration of public and private sector approaches with the focus on costs and feasibility. Results: The final model includes components that aim to improve community awareness, a home-based screening service, patient and provider incentives to seek and deliver treatment specifically for hypertension, and adherence support. The expected outcomes projected by this model could prove potentially cost effective and affordable (1 USD/person/year. The model is currently being implemented in a Nairobi slum and is closely followed by key stakeholders in Kenya including the Ministry of Health, the World Health Organization (WHO, and leading non-governmental organizations (NGOs. Conclusion: Through the collaboration of public health and private sectors, a theoretically cost-effective model was developed for the prevention of CVD and is currently being implemented in the slums of Nairobi. If results are in line with the theoretical projections and first impressions on the ground, scale-up of the service delivery package could be planned in other poor urban areas in Kenya by

  8. Surface-groundwater interactions in hard rocks in Sardon Catchment of western Spain: an integrated modeling approach

    NARCIS (Netherlands)

    Tanvir Hassan, S.M.; Lubczynski, M.; Niswonger, R.G.; Su, Zhongbo

    2014-01-01

    The structural and hydrological complexity of hard rock systems (HRSs) affects dynamics of surface–groundwater interactions. These complexities are not well described or understood by hydrogeologists because simplified analyses typically are used to study HRSs. A transient, integrated hydrologic

  9. Operationalizing the integrated landscape approach in practice

    Directory of Open Access Journals (Sweden)

    Olivia E. Freeman

    2015-03-01

    the process of taking a landscape approach. Drawing on a review of the literature, we identify and discuss three different kinds of landscape approaches: using the landscape scale, a sectoral landscape approach, and an integrated landscape approach. Focusing on an integrated landscape approach, we examine five concepts to help characterize landscape approaches: multifunctionality, transdisciplinarity, participation, complexity, and sustainability. For each term, a continuum of application exists. To help improve and move the integrated landscape approach more toward operationalization, more focus needs to be placed on the process of taking the approach. Although the process can be implemented in a range of ways, in a more integrated approach it will require explicitly defined objectives as well as a clear understanding of what is meant by multifunctionality and sustainability. It will also require collaborative participation, transdisciplinarity/cross-sectoral approaches, managing for adaptive capacity, and applying an iterative process to address the inherent complexity within the system. Although these concepts are not new, we present continuums on which they can exist, allowing for clarification and distinctions to be made regarding what it means to take a landscape approach.

  10. Integrated reclamation: Approaching ecological function?

    Science.gov (United States)

    Ann L. Hild; Nancy L. Shaw; Ginger B. Paige

    2009-01-01

    Attempts to reclaim arid and semiarid lands have traditionally targeted plant species composition. Much research attention has been directed to seeding rates, species mixes and timing of seeding. However, in order to attain functioning systems, attention to structure and process must compliment existing efforts. We ask how to use a systems approach to enhance...

  11. Integration of observations, modelling approaches and remote sensing to address ecosystem response to climate change and disturbance in Africa

    Science.gov (United States)

    Falge, Eva; Brümmer, Christian

    2017-04-01

    African societies face growing global change challenges and several associated risks. These include rapidly changing patterns of human settlements and an intensified use of ecosystem services. At the same time, climate variability and change are amplifying stress on the functionality of ecosystems and their critical role as important greenhouse gas sinks. A recent review (Valentini et al. 2014) attests Africa a key role in the global carbon cycle contributing an absolute annual carbon sink (-0.61 ± 0.58 Pg C yr-1), which may partly been offset through understudied emissions of CH4 and N2O. The net sink strength is characterized by a substantial sub-regional spatial variability due to biome distribution and degree of anthropogenic influences. 52% of the global carbon emissions by fire are due to African wildfires, which contribute with 1.03 ± 0.22 Pg C yr-1 twice the emissions caused by land use change in Africa (0.51 ± 0.10 Pg C yr-1). Moreover, a quarter of the interannual variability of the global carbon budget is due to the year-to-year variation (± 0.5 Pg C yr-1) of carbon fluxes on the African continent. Among the archetypes to address the above-mentioned challenges in an integrated and multidisciplinary way are better data bases which serve as constraints for atmospheric data and models, thorough attempts to reduce GHG flux uncertainties, or enhanced understanding of climatic, hydrological, and socio-economic drivers of temporal and spatial variability of GHG balances. Some examples from the ARS-AfricaE project that will serve to illustrate the wide range of such activities include: Measurements of CO2 exchange, ecosystem structure and eco-physiological properties at paired sites with natural and managed vegetation, Further development and application of the adaptive Dynamic Global Vegetation Model 2 (aDGVM2) to investigate the influence of different atmospheric CO2 scenarios on carbon pools and fluxes of a selected ecosystem in Skukuza, Kruger National

  12. Social Ecological Model Analysis for ICT Integration

    Science.gov (United States)

    Zagami, Jason

    2013-01-01

    ICT integration of teacher preparation programmes was undertaken by the Australian Teaching Teachers for the Future (TTF) project in all 39 Australian teacher education institutions and highlighted the need for guidelines to inform systemic ICT integration approaches. A Social Ecological Model (SEM) was used to positively inform integration…

  13. Economic Impacts of Total Water Use Control in the Heihe River Basin in Northwestern China—An Integrated CGE-BEM Modeling Approach

    Directory of Open Access Journals (Sweden)

    Na Li

    2015-03-01

    Full Text Available This paper develops an integrated modeling approach combined with a top-down dynamic computable general equilibrium (CGE model and a bottom-up bio-economic model (BEM to study the economic impact of a total water use control policy in the Heihe river basin, northwestern China. The integrated CGE-BEM model is regionally disaggregated with a variety of crops and livestock, and includes the responses of farmers and consequent feedback effects in the regional economic system. The results show that under the total water use control scenario, the water use structure is changed and water use efficiency is improved. The total water use control policy has limited negative impact on the regional economic growth with only a slightly lower growth rate of 13.38% compared with a growth rate of 14% by 2020 under a business as usual water use scenario. However, the total water use control policy has significant negative impacts on several sectors, especially agriculture and food processing. It is expected cropping systems will change through a replacement of water-intensive crops with water-efficient crops. Farmers’ incomes will decrease by 3.14%. In order to alleviate farmers’ income loss and deal with water use conflicts across different sectors and regions, the promotion of migration of surplus labor from agriculture to non-agricultural sectors and the improvement of water use efficiency in agriculture are needed.

  14. Tight-coupling of groundwater flow and transport modelling engines with spatial databases and GIS technology: a new approach integrating Feflow and ArcGIS

    Directory of Open Access Journals (Sweden)

    Ezio Crestaz

    2012-09-01

    Full Text Available Implementation of groundwater flow and transport numerical models is generally a challenge, time-consuming and financially-demanding task, in charge to specialized modelers and consulting firms. At a later stage, within clearly stated limits of applicability, these models are often expected to be made available to less knowledgeable personnel to support/design and running of predictive simulations within more familiar environments than specialized simulation systems. GIS systems coupled with spatial databases appear to be ideal candidates to address problem above, due to their much wider diffusion and expertise availability. Current paper discusses the issue from a tight-coupling architecture perspective, aimed at integration of spatial databases, GIS and numerical simulation engines, addressing both observed and computed data management, retrieval and spatio-temporal analysis issues. Observed data can be migrated to the central database repository and then used to set up transient simulation conditions in the background, at run time, while limiting additional complexity and integrity failure risks as data duplication during data transfer through proprietary file formats. Similarly, simulation scenarios can be set up in a familiar GIS system and stored to spatial database for later reference. As numerical engine is tightly coupled with the GIS, simulations can be run within the environment and results themselves saved to the database. Further tasks, as spatio-temporal analysis (i.e. for postcalibration auditing scopes, cartography production and geovisualization, can then be addressed using traditional GIS tools. Benefits of such an approach include more effective data management practices, integration and availability of modeling facilities in a familiar environment, streamlining spatial analysis processes and geovisualization requirements for the non-modelers community. Major drawbacks include limited 3D and time-dependent support in

  15. Modeling vehicle fuel consumption and emissions at signalized intersection approaches : integrating field-collected data into microscopic simulation.

    Science.gov (United States)

    2012-07-01

    Microscopic models produce emissions and fuel consumption estimates with higher temporal resolution than other scales of : models. Most emissions and fuel consumption models were developed with data from dynamometer testing which are : sufficiently a...

  16. Integrative medicine approach to chronic pain.

    Science.gov (United States)

    Teets, Raymond Y; Dahmer, Stephen; Scott, Emilie

    2010-06-01

    Chronic pain can be a frustrating condition for patient and clinician. The integrative medicine approach to pain can offer hope, adding safe complementary and alternative medical (CAM) therapies to mitigate pain and suffering. Such CAM therapies include nutrition, supplements and herbs, manual medicine, acupuncture, yoga, and mind-body approaches. The evidence is heterogeneous regarding these approaches, but some evidence suggests efficacy and confirms safety. The integrative medicine approach can be beneficial in a patient with chronic pain. Copyright 2010 Elsevier Inc. All rights reserved.

  17. Towards an Integrated Approach o Cohesion and Coherence in ...

    African Journals Online (AJOL)

    ... an integrated approach is proposed as a viable approach to cohesion and coherence in interlingual subtitling. Advantages and implications of this integrated approach are highlighted for further research. Keywords: Integrated Approach, Cohesion, Coherence, Interlingual Subtitling, Metafunctional Semiotic Theory ...

  18. Integrative structure modeling with the Integrative Modeling Platform.

    Science.gov (United States)

    Webb, Benjamin; Viswanath, Shruthi; Bonomi, Massimiliano; Pellarin, Riccardo; Greenberg, Charles H; Saltzberg, Daniel; Sali, Andrej

    2018-01-01

    Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (https://integrativemodeling.org), and demonstrate its use. © 2017 The Protein Society.

  19. An integral approach to compliance.

    Science.gov (United States)

    Goddard, T G

    2000-08-01

    Financial managers of managed care organizations should structure their compliance plans to conform with requirements shaped by forces such as judicial decisions and extralegal standards for managed care operations, in addition to state and Federal laws and regulations. In addition to researching the law and training employees, an integral compliance plan should include monitoring organizational systems that can encourage or impede compliance, measuring employees' motivation to adhere to compliance standards, and modifying corporate culture to support compliance goals. Managed care organizations should empower compliance officers with a broad range of tools to assess and improve compliance efforts, or risk having organizational decisions examined externally through the lens of an onerous, dynamic system of laws and judicial decisions.

  20. Functional integral approach to classical statistical dynamics

    International Nuclear Information System (INIS)

    Jensen, R.V.

    1980-04-01

    A functional integral method is developed for the statistical solution of nonlinear stochastic differential equations which arise in classical dynamics. The functional integral approach provides a very natural and elegant derivation of the statistical dynamical equations that have been derived using the operator formalism of Martin, Siggia, and Rose

  1. Functional integral approach to classical statistical dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, R.V.

    1980-04-01

    A functional integral method is developed for the statistical solution of nonlinear stochastic differential equations which arise in classical dynamics. The functional integral approach provides a very natural and elegant derivation of the statistical dynamical equations that have been derived using the operator formalism of Martin, Siggia, and Rose.

  2. Improved Models to Integrated Berth Allocation-Quay Crane Assignment Problem: A Computational Comparison and Novel Solution Approaches

    DEFF Research Database (Denmark)

    Iris, Cagatay; Pacino, Dario; Røpke, Stefan

    of the vessels primarily depends on the number of containers to be handled and the number of cranes deployed, it would be beneficial to consider the integration of those two problems. This work extends the state-of-the-art by strengthening the current best mathematical formulation. Computational experiments...

  3. Pedagogical Approaches to Cooperative Education in South Africa: A Work-Integrated Learning Model for the Public Relations Industry

    Science.gov (United States)

    Rampersad, Renitha

    2010-01-01

    The pedagogy relevant to work-integrated learning (WIL) has formed a significant component of most educational processes and has become a necessity for the public relations industry in South Africa. Properly planned, designed and monitored programmes expose students to professional culture and workplace practice. This paper outlines the pedagogy…

  4. Evaluation of OASIS QSAR Models Using ToxCast™ in Vitro Estrogen and Androgen Receptor Binding Data and Application in an Integrated Endocrine Screening Approach

    Science.gov (United States)

    Bhhatarai, Barun; Wilson, Daniel M.; Price, Paul S.; Marty, Sue; Parks, Amanda K.; Carney, Edward

    2016-01-01

    Background: Integrative testing strategies (ITSs) for potential endocrine activity can use tiered in silico and in vitro models. Each component of an ITS should be thoroughly assessed. Objectives: We used the data from three in vitro ToxCast™ binding assays to assess OASIS, a quantitative structure-activity relationship (QSAR) platform covering both estrogen receptor (ER) and androgen receptor (AR) binding. For stronger binders (described here as AC50 QSAR predictions of ER or AR binding to the results from 18 ER and 10 AR transactivation assays, 72 ER-binding reference compounds, and the in vivo uterotrophic assay. Methods: NovaScreen binding assay data for ER (human, bovine, and mouse) and AR (human, chimpanzee, and rat) were used to assess the sensitivity, specificity, concordance, and applicability domain of two OASIS QSAR models. The binding strength relative to the QSAR-predicted binding strength was examined for the ER data. The relationship of QSAR predictions of binding to transactivation- and pathway-based assays, as well as to in vivo uterotrophic responses, was examined. Results: The QSAR models had both high sensitivity (> 75%) and specificity (> 86%) for ER as well as both high sensitivity (92–100%) and specificity (70–81%) for AR. For compounds within the domains of the ER and AR QSAR models that bound with AC50 QSAR models accurately predicted the binding for the parent compounds. The parent compounds were active in all transactivation assays where metabolism was incorporated and, except for those compounds known to require metabolism to manifest activity, all assay platforms where metabolism was not incorporated. Compounds in-domain and predicted to bind by the ER QSAR model that were positive in ToxCast™ ER binding at AC50 QSAR models had high sensitivity and specificity when compounds were in-domain of the models. Based on this research, we recommend a tiered screening approach wherein a) QSAR is used to identify compounds in-domain of

  5. Integrative Approach to Psoriasis Vulgaris.

    Science.gov (United States)

    Ljubenovic, Milanka; Lazarevic, Viktor; Golubovic, Masa; Binic, Ivana

    2017-12-19

    In this article, we present a literature review of the most popular and commonly used therapeutic procedures belonging to complementary and alternative medicine, which is part of the modern concept of integrative medicine, used in the treatment of psoriasis. Psoriasis is a chronic, systemic, inflammatory disease wherein skin changes are the most visible sign. It occurs in approximately 1% to 3% of the world population, and the National Psoriasis Foundation of the United States estimates the number of patients in the whole world at about 125 million. Psoriasis primarily affects the skin, burdening patients with inflamed, pruritic, and sometimes painful lesions covered with whitish scales that last for years. Because of its prevalence in the general population, diversity of the clinical picture (from minimal and localized lesions without subjective symptoms to life-threatening conditions), and disease duration (practically a lifetime), psoriasis is a disease that has become a focus of modern medicine, and therapeutic options for the treatment of psoriasis are currently very numerous and diverse. Conventional treatment of psoriasis is guided by the so-called principle of "steps," where treatment options are applied according to the severity of illness assessed by a physician. Apart from the official therapy for psoriasis, as it is defined and understood in modern developed societies, there exists in parallel a great number of traditional, complementary, and alternative psoriasis treatments, which are based on the beliefs, experiences, and theories inherent to different cultures; in this article, we have analyzed the literature related to some of these procedures.

  6. Development of system based code for integrity of FBR. Fundamental probabilistic approach, Part 1: Model calculation of creep-fatigue damage (Research report)

    International Nuclear Information System (INIS)

    Kawasaki, Nobuchika; Asayama, Tai

    2001-09-01

    Both reliability and safety have to be further improved for the successful commercialization of FBRs. At the same time, construction and operation costs need to be reduced to a same level of future LWRs. To realize compatibility among reliability, safety and, cost, the Structural Mechanics Research Group in JNC started the development of System Based Code for Integrity of FBR. This code extends the present structural design standard to include the areas of fabrication, installation, plant system design, safety design, operation and maintenance, and so on. A quantitative index is necessary to connect different partial standards in this code. Failure probability is considered as a candidate index. Therefore we decided to make a model calculation using failure probability and judge its applicability. We first investigated other probabilistic standards like ASME Code Case N-578. A probabilistic approach in the structural integrity evaluation was created based on these results, and also an evaluation flow was proposed. According to this flow, a model calculation of creep-fatigue damage was performed. This trial calculation was for a vessel in a sodium-cooled FBR. As the result of this model calculation, a crack initiation probability and a crack penetration probability were found to be effective indices. Last we discussed merits of this System Based Code, which are presented in this report. Furthermore, this report presents future development tasks. (author)

  7. Integrated reporting: A new approach to corporate reporting and management

    OpenAIRE

    Prošić Danica

    2015-01-01

    Integrated reporting is an opportunity to present a comprehensive picture of one's business in a clear, concise, coherent and comparable way. The idea of an integrated reporting and integration with non-financial data in the annual reports has many advantages and benefits compared to the current model of corporate reporting. Such approach enables us to consider the material issues facing our business and the community, and show how we create value for shareholders and society as a whole. At t...

  8. Toward an Integrated Psychological Approach - Phase II

    International Development Research Centre (IDRC) Digital Library (Canada)

    Trauma, Development and Peacebuilding : Toward an Integrated Psychological Approach - Phase II. Over the past decade, the peace, conflict and development community has begun to question the value of medicalized approaches such as post-traumatic stress disorder (PTSD) in dealing with aftermath of political violence ...

  9. A New Approach to Integrate Internet-of-Things and Software-as-a-Service Model for Logistic Systems: A Case Study

    Directory of Open Access Journals (Sweden)

    Shang-Liang Chen

    2014-03-01

    Full Text Available Cloud computing is changing the ways software is developed and managed in enterprises, which is changing the way of doing business in that dynamically scalable and virtualized resources are regarded as services over the Internet. Traditional manufacturing systems such as supply chain management (SCM, customer relationship management (CRM, and enterprise resource planning (ERP are often developed case by case. However, effective collaboration between different systems, platforms, programming languages, and interfaces has been suggested by researchers. In cloud-computing-based systems, distributed resources are encapsulated into cloud services and centrally managed, which allows high automation, flexibility, fast provision, and ease of integration at low cost. The integration between physical resources and cloud services can be improved by combining Internet of things (IoT technology and Software-as-a-Service (SaaS technology. This study proposes a new approach for developing cloud-based manufacturing systems based on a four-layer SaaS model. There are three main contributions of this paper: (1 enterprises can develop their own cloud-based logistic management information systems based on the approach proposed in this paper; (2 a case study based on literature reviews with experimental results is proposed to verify that the system performance is remarkable; (3 challenges encountered and feedback collected from T Company in the case study are discussed in this paper for the purpose of enterprise deployment.

  10. A new approach to integrate Internet-of-things and software-as-a-service model for logistic systems: a case study.

    Science.gov (United States)

    Chen, Shang-Liang; Chen, Yun-Yao; Hsu, Chiang

    2014-03-28

    Cloud computing is changing the ways software is developed and managed in enterprises, which is changing the way of doing business in that dynamically scalable and virtualized resources are regarded as services over the Internet. Traditional manufacturing systems such as supply chain management (SCM), customer relationship management (CRM), and enterprise resource planning (ERP) are often developed case by case. However, effective collaboration between different systems, platforms, programming languages, and interfaces has been suggested by researchers. In cloud-computing-based systems, distributed resources are encapsulated into cloud services and centrally managed, which allows high automation, flexibility, fast provision, and ease of integration at low cost. The integration between physical resources and cloud services can be improved by combining Internet of things (IoT) technology and Software-as-a-Service (SaaS) technology. This study proposes a new approach for developing cloud-based manufacturing systems based on a four-layer SaaS model. There are three main contributions of this paper: (1) enterprises can develop their own cloud-based logistic management information systems based on the approach proposed in this paper; (2) a case study based on literature reviews with experimental results is proposed to verify that the system performance is remarkable; (3) challenges encountered and feedback collected from T Company in the case study are discussed in this paper for the purpose of enterprise deployment.

  11. Systems innovation model: an integrated interdisciplinary team approach pre- and post-bariatric surgery at a veterans affairs (VA) medical center.

    Science.gov (United States)

    Eisenberg, Dan; Lohnberg, Jessica A; Kubat, Eric P; Bates, Cheryl C; Greenberg, Lauren M; Frayne, Susan M

    2017-04-01

    Provision of bariatric surgery in the Veterans Health Administration must account for obese veterans' co-morbidity burden and the geographically dispersed location of patients relative to Veterans Affairs (VA) bariatric centers. To evaluate a collaborative, integrated, interdisciplinary bariatric team of surgeons, bariatricians, psychologists, dieticians, and physical therapists working in a hub-and-spokes care model, for pre- and post-bariatric surgery assessment and management. This is a description of an interdisciplinary clinic and bariatric program at a VA healthcare system and a report on program evaluation findings. Retrospective data of a prospective database was abstracted. For program evaluation, we abstracted charts to characterize patient data and conducted a patient survey. Since 2009, 181 veterans have undergone bariatric surgery. Referrals came from 7 western U.S. states. Mean preoperative body mass index was 46 kg/m 2 (maximum 71). Mean age was 53 years, with 33% aged>60 years; 79% were male. Medical co-morbidity included diabetes (70%), hypertension (85%), and lower back or extremity joint pain (84%). A psychiatric diagnosis was present in 58%. At 12 months, follow-up was 81% and percent excess body mass index loss was 50.5%. Among 54 sequential clinic patients completing anonymous surveys, overall satisfaction with the interdisciplinary team approach and improved quality of life were high (98% and 94%, respectively). The integrated, interdisciplinary team approach using a hub-and-spokes model is well suited to the VA bariatric surgery population, with its heavy burden of medical and mental health co-morbidity and its system of geographically dispersed patients receiving treatment at specialty centers. As the VA seeks to expand the use of bariatric surgery as an option for obese veterans, interdisciplinary models crafted to address case complexity, care coordination, and long-term outcomes should be part of policy planning efforts. Published by

  12. Integrating Environmental and Mosquito Data to Model Disease: Evaluating Alternative Modeling Approaches for Forecasting West Nile Virus in South Dakota, USA

    Science.gov (United States)

    Davis, J. K.; Vincent, G. P.; Hildreth, M.; Kightlinger, L.; Carlson, C.; Wimberly, M. C.

    2017-12-01

    South Dakota has the highest annual incidence of human cases of West Nile virus (WNV) in all US states, and human cases can vary wildly among years; predicting WNV risk in advance is a necessary exercise if public health officials are to respond efficiently and effectively to risk. Case counts are associated with environmental factors that affect mosquitoes, avian hosts, and the virus itself. They are also correlated with entomological risk indices obtained by trapping and testing mosquitoes. However, neither weather nor insect data alone provide a sufficient basis to make timely and accurate predictions, and combining them into models of human disease is not necessarily straightforward. Here we present lessons learned in three years of making real-time forecasts of this threat to public health. Various methods of integrating data from NASA's North American Land Data Assimilation System (NLDAS) with mosquito surveillance data were explored in a model comparison framework. We found that a model of human disease summarizing weather data (by polynomial distributed lags with seasonally-varying coefficients) and mosquito data (by a mixed-effects model that smooths out these sparse and highly-variable data) made accurate predictions of risk, and was generalizable enough to be recommended in similar applications. A model based on lagged effects of temperature and humidity provided the most accurate predictions. We also found that model accuracy was improved by allowing coefficients to vary smoothly throughout the season, giving different weights to different predictor variables during different parts of the season.

  13. AIM: An Integrated Approach to Organizational Improvement

    Directory of Open Access Journals (Sweden)

    Ronald A. Styron, Jr.

    2016-02-01

    Full Text Available This concept paper is based on the new problem-solving model of Blended Leadership called Alloy Improvement Model (AIM. This model consists of an integration of change theory, leadership theory, and democratic principles and practices to form a comprehensive problem-solving strategy for organizational leaders. The utilization of AIM will assist leaders in moving from problems to solutions while engaging stakeholders in a comprehensive, efficient, inclusive, informative, integrated and transparent process.

  14. Quantum gravitation. The Feynman path integral approach

    International Nuclear Information System (INIS)

    Hamber, Herbert W.

    2009-01-01

    The book covers the theory of Quantum Gravitation from the point of view of Feynman path integrals. These provide a manifestly covariant approach in which fundamental quantum aspects of the theory such as radiative corrections and the renormalization group can be systematically and consistently addressed. The path integral method is suitable for both perturbative as well as non-perturbative studies, and is known to already provide a framework of choice for the theoretical investigation of non-abelian gauge theories, the basis for three of the four known fundamental forces in nature. The book thus provides a coherent outline of the present status of the theory gravity based on Feynman's formulation, with an emphasis on quantitative results. Topics are organized in such a way that the correspondence to similar methods and results in modern gauge theories becomes apparent. Covariant perturbation theory are developed using the full machinery of Feynman rules, gauge fixing, background methods and ghosts. The renormalization group for gravity and the existence of non-trivial ultraviolet fixed points are investigated, stressing a close correspondence with well understood statistical field theory models. Later the lattice formulation of gravity is presented as an essential tool towards an understanding of key features of the non-perturbative vacuum. The book ends with a discussion of contemporary issues in quantum cosmology such as scale dependent gravitational constants and quantum effects in the early universe. (orig.)

  15. Optimizing conjunctive use of surface water and groundwater for irrigation in arid and semi-arid areas: an integrated modeling approach

    Science.gov (United States)

    Wu, Xin; Wu, Bin; Zheng, Yi; Tian, Yong; Liu, Jie; Zheng, Chunmiao

    2015-04-01

    In arid and semi-arid agricultural areas, groundwater (GW) is an important water source of irrigation, in addition to surface water (SW). Groundwater pumping would significantly alter the regional hydrological regime, and therefore complicate the water resources management process. This study explored how to optimize the conjunctive use of SW and GW for agricultural irrigation at a basin scale, based on integrated SW-GW modeling and global optimization methods. The improved GSFLOW model was applied to the Heihe River Basin, the second largest inland river basin in China. Two surrogate-based global optimization approaches were implemented and compared, including the well-established DYCORS algorithm and a new approach we proposed named as SOIM, which takes radial basis function (RBF) and support vector machine (SVM) as the surrogate model, respectively. Both temporal and spatial optimizations were performed, aiming at maximizing saturated storage change of midstream part conditioned on non-reduction of irrigation demand, constrained by certain annual discharge for the downstream part. Several scenarios for different irrigation demand and discharge flow are designed. The main study results include the following. First, the integrated modeling not only provides sufficient flexibility to formulation of optimization problems, but also makes the optimization results more physically interpretable and managerially meaningful. Second, the surrogate-based optimization approach was proved to be effective and efficient for the complex, time-consuming modeling, and is quite promising for decision-making. Third, the strong and complicated SW-GW interactions in the study area allow significant water resources conservation, even if neither irrigation demand nor discharge for the downstream part decreases. Under the optimal strategy, considerable part of surface water division is replaced by 'Stream leakage-Pump' process to avoid non-beneficial evaporation via canals. Spatially

  16. Integrated modelling approach to simulate the long-term chemical evolution of cementitious materials in radioactive waste repository environment

    International Nuclear Information System (INIS)

    Elakneswaran, Y.; Ishida, T.

    2015-01-01

    A multi-scale chemo-physics model called Durability Concrete Model (DuCOM) and the geochemical transport code PHREEQC were coupled to predict the long-term performance of cementitious materials in nuclear waste repository environment. The coupled model retains all the capability of each model and allows the prediction of the spatio-temporal variation of cement hydrate composition, pore water concentration, other hydration and pore structure properties, etc. simultaneously. In contrast to existing models, DuCOM-PHREEQC does not require physical or chemical properties of cementitious materials in advance as input parameters because these are calculated automatically in the model. The simulation result from DuCOM-PHREEQC system was verified with reported experimental data for total calcium content in cement paste exposed to pure water. The good agreement between the calculation and the experimental data indicates that the important features and processes have been included in the model for the assessment of cementitious materials in radioactive waste repository environment. Finally, the importance of the strong coupling among various processes and mechanisms in the DuCOM-PHREEQC system is discussed

  17. Toward a Unified Integration Approach: Uniting Diverse Primary Care Strategies Under the Primary Care Behavioral Health (PCBH) Model.

    Science.gov (United States)

    Sandoval, Brian E; Bell, Jennifer; Khatri, Parinda; Robinson, Patricia J

    2017-12-12

    Primary care continues to be at the center of health care transformation. The Primary Care Behavioral Health (PCBH) model of service delivery includes patient-centered care delivery strategies that can improve clinical outcomes, cost, and patient and primary care provider satisfaction with services. This article reviews the link between the PCBH model of service delivery and health care services quality improvement, and provides guidance for initiating PCBH model clinical pathways for patients facing depression, chronic pain, alcohol misuse, obesity, insomnia, and social barriers to health.

  18. Systematic Approach to Better Understanding Integration Costs

    Energy Technology Data Exchange (ETDEWEB)

    Stark, Gregory B. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-01

    This research presents a systematic approach to evaluating the costs of integrating new generation and operational procedures into an existing power system, and the methodology is independent of the type of change or nature of the generation. The work was commissioned by the U.S. Department of Energy and performed by the National Renewable Energy Laboratory to investigate three integration cost-related questions: (1) How does the addition of new generation affect a system's operational costs, (2) How do generation mix and operating parameters and procedures affect costs, and (3) How does the amount of variable generation (non-dispatchable wind and solar) impact the accuracy of natural gas orders? A detailed operational analysis was performed for seven sets of experiments: variable generation, large conventional generation, generation mix, gas prices, fast-start generation, self-scheduling, and gas supply constraints. For each experiment, four components of integration costs were examined: cycling costs, non-cycling VO&M costs, fuel costs, and reserves provisioning costs. The investigation was conducted with PLEXOS production cost modeling software utilizing an updated version of the Institute of Electrical and Electronics Engineers 118-bus test system overlaid with projected operating loads from the Western Electricity Coordinating Council for the Sacramento Municipal Utility District, Puget Sound Energy, and Public Service Colorado in the year 2020. The test system was selected in consultation with an industry-based technical review committee to be a reasonable approximation of an interconnection yet small enough to allow the research team to investigate a large number of scenarios and sensitivity combinations. The research should prove useful to market designers, regulators, utilities, and others who want to better understand how system changes can affect production costs.

  19. Integrated modeling approach using SELECT and SWAT models to simulate source loading and in-stream conditions of fecal indicator bacteria.

    Science.gov (United States)

    Ranatunga, T.

    2016-12-01

    Modeling of fate and transport of fecal bacteria in a watershed is generally a processed based approach that considers releases from manure, point sources, and septic systems. Overland transport with water and sediments, infiltration into soils, transport in the vadose zone and groundwater, die-off and growth processes, and in-stream transport are considered as the other major processes in bacteria simulation. This presentation will discuss a simulation of fecal indicator bacteria (E.coli) source loading and in-stream conditions of a non-tidal watershed (Cedar Bayou Watershed) in South Central Texas using two models; Spatially Explicit Load Enrichment Calculation Tool (SELECT) and Soil and Water Assessment Tool (SWAT). Furthermore, it will discuss a probable approach of bacteria source load reduction in order to meet the water quality standards in the streams. The selected watershed is listed as having levels of fecal indicator bacteria that posed a risk for contact recreation and wading by the Texas Commission of Environmental Quality (TCEQ). The SELECT modeling approach was used in estimating the bacteria source loading from land categories. Major bacteria sources considered were, failing septic systems, discharges from wastewater treatment facilities, excreta from livestock (Cattle, Horses, Sheep and Goat), excreta from Wildlife (Feral Hogs, and Deer), Pet waste (mainly from Dogs), and runoff from urban surfaces. The estimated source loads were input to the SWAT model in order to simulate the transport through the land and in-stream conditions. The calibrated SWAT model was then used to estimate the indicator bacteria in-stream concentrations for future years based on H-GAC's regional land use, population and household projections (up to 2040). Based on the in-stream reductions required to meet the water quality standards, the corresponding required source load reductions were estimated.

  20. The Design and Implementation of Eco-Evolutionary PVA Models: An Integrative Approach Using HexSim

    Science.gov (United States)

    To persist into the future, species of conservation concern must remain both demographically and genetically viable. Developing mitigation and recovery strategies to ensure species’ viability necessitates the use of forecasting models that can incorporate ecological and/or...

  1. A Key Event Path Analysis Approach for Integrated Systems

    Directory of Open Access Journals (Sweden)

    Jingjing Liao

    2012-01-01

    Full Text Available By studying the key event paths of probabilistic event structure graphs (PESGs, a key event path analysis approach for integrated system models is proposed. According to translation rules concluded from integrated system architecture descriptions, the corresponding PESGs are constructed from the colored Petri Net (CPN models. Then the definitions of cycle event paths, sequence event paths, and key event paths are given. Whereafter based on the statistic results after the simulation of CPN models, key event paths are found out by the sensitive analysis approach. This approach focuses on the logic structures of CPN models, which is reliable and could be the basis of structured analysis for discrete event systems. An example of radar model is given to characterize the application of this approach, and the results are worthy of trust.

  2. Using an Integrated Participatory Modeling Approach to Assess Water Management Options and Support Community Conversations on Maui

    Directory of Open Access Journals (Sweden)

    Rushil S. Mistry

    2009-12-01

    Full Text Available The purpose of this study is to provide an integrated analysis of water distribution on Maui and the cross-sectoral impacts of policies and regulations aimed at rejuvenating and sustaining the deep-rooted culture on the island. Since the water diversion system was implemented in 1876 on the island of Maui, there has been contention among local interest groups over the right way to manage and allocate this precious resource. There is also concern over the availability of the precious resource in the long term, as the demand for water is expected to exceed the potential supply of water on Maui by 2020. This paper analyzes various long run scenarios of policy options presently being discussed on Maui. By collaborating with local experts, business leaders, and community members, to develop a tool that facilitates policy formulation and evaluation, informed decisions can then be made by the local community to ensure sustainable development.

  3. An integrated model for developing research skills in an undergraduate medical curriculum: appraisal of an approach using student selected components.

    Science.gov (United States)

    Riley, Simon C; Morton, Jeremy; Ray, David C; Swann, David G; Davidson, Donald J

    2013-09-01

    Student selected components (SSCs), at that time termed special study modules, were arguably the most innovative element in Tomorrow's Doctors (1993), the document from the General Medical Council that initiated the modernization of medical curricula in the UK. SSCs were proposed to make up one-third of the medical curriculum and provide students with choice, whilst allowing individual schools autonomy in how SSCs were utilized. In response, at the University of Edinburgh the undergraduate medical curriculum provides an integrated and sequential development and assessment of research skill learning outcomes, for all students in the SSC programme. The curriculum contains SSCs which provide choice to students in all 5 years. There are four substantial timetabled SSCs where students develop research skills in a topic and speciality of their choice. These SSCs are fully integrated and mapped with core learning outcomes and assessment, particularly with the 'Evidence-Based Medicine and Research' programme theme. These research skills are developed incrementally and applied fully in a research project in the fourth year. One-third of students also perform an optional intercalated one-year honours programme between years 2 and 3, usually across a wide range of honours schools at the biomedical science interface. Student feedback is insightful and demonstrates perceived attainment of research competencies. The establishment of these competencies is discussed in the context of enabling junior graduate doctors to be effective and confident at utilizing their research skills to effectively practice evidence-based medicine. This includes examining their own practice through clinical audit, developing an insight into the complexity of the evidence base and uncertainty, and also gaining a view into a career as a clinical academic.

  4. Science based integrated approach to advanced nuclear fuel development - integrated multi-scale multi-physics hierarchical modeling and simulation framework Part III: cladding

    Energy Technology Data Exchange (ETDEWEB)

    Tome, Carlos N [Los Alamos National Laboratory; Caro, J A [Los Alamos National Laboratory; Lebensohn, R A [Los Alamos National Laboratory; Unal, Cetin [Los Alamos National Laboratory; Arsenlis, A [LLNL; Marian, J [LLNL; Pasamehmetoglu, K [INL

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Reactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems to develop predictive tools is critical. Not only are fabrication and performance models needed to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. In this paper we review the current status of the advanced modeling and simulation of nuclear reactor cladding, with emphasis on what is available and what is to be developed in each scale of the project, how we propose to pass information from one scale to the next, and what experimental information is required for benchmarking and advancing the modeling at each scale level.

  5. Curriculum Integration Using Enterprise Resource Planning: An Integrative Case Approach

    Science.gov (United States)

    Cannon, David M.; Klein, Helen A; Koste, Lori L.; Magal, Simha R.

    2004-01-01

    Efforts to achieve greater curriculum integration in schools of business have included team teaching, student group projects, multidisciplinary cases, and, more recently, the use of enterprise resource planning (ERP) systems. Although these approaches are beneficial, they tend to be implemented on an ad hoc basis rather than through curriculum…

  6. An Integrated Numerical Modelling-Discrete Fracture Network Approach Applied to the Characterisation of Rock Mass Strength of Naturally Fractured Pillars

    Science.gov (United States)

    Elmo, Davide; Stead, Doug

    2010-02-01

    Naturally fractured mine pillars provide an excellent example of the importance of accurately determining rock mass strength. Failure in slender pillars is predominantly controlled by naturally occurring discontinuities, their influence diminishing with increasing pillar width, with wider pillars failing through a combination of brittle and shearing processes. To accurately simulate this behaviour by numerical modelling, the current analysis incorporates a more realistic representation of the mechanical behaviour of discrete fracture systems. This involves realistic simulation and representation of fracture networks, either as individual entities or as a collective system of fracture sets, or a combination of both. By using an integrated finite element/discrete element-discrete fracture network approach it is possible to study the failure of rock masses in tension and compression, along both existing pre-existing fractures and through intact rock bridges, and incorporating complex kinematic mechanisms. The proposed modelling approach fully captures the anisotropic and inhomogeneous effects of natural jointing and is considered to be more realistic than methods relying solely on continuum or discontinuum representation. The paper concludes with a discussion on the development of synthetic rock mass properties, with the intention of providing a more robust link between rock mass strength and rock mass classification systems.

  7. Integrated approaches to miRNAs target definition: time-series analysis in an osteosarcoma differentiative model.

    Science.gov (United States)

    Grilli, A; Sciandra, M; Terracciano, M; Picci, P; Scotlandi, K

    2015-06-30

    microRNAs (miRs) are small non-coding RNAs involved in the fine regulation of several cellular processes by inhibiting their target genes at post-transcriptional level. Osteosarcoma (OS) is a tumor thought to be related to a molecular blockade of the normal process of osteoblast differentiation. The current paper explores temporal transcriptional modifications comparing an osteosarcoma cell line, Saos-2, and clones stably transfected with CD99, a molecule which was found to drive OS cells to terminally differentiate. Parental cell line and CD99 transfectants were cultured up to 14 days in differentiating medium. In this setting, OS cells were profiled by gene and miRNA expression arrays. Integration of gene and miRNA profiling was performed by both sequence complementarity and expression correlation. Further enrichment and network analyses were carried out to focus on the modulated pathways and on the interactions between transcriptome and miRNome. To track the temporal transcriptional modification, a PCA analysis with differentiated human MSC was performed. We identified a strong (about 80 %) gene down-modulation where reversion towards the osteoblast-like phenotype matches significant enrichment in TGFbeta signaling players like AKT1 and SMADs. In parallel, we observed the modulation of several cancer-related microRNAs like miR-34a, miR-26b or miR-378. To decipher their impact on the modified transcriptional program in CD99 cells, we correlated gene and microRNA time-series data miR-34a, in particular, was found to regulate a distinct subnetwork of genes with respect to the rest of the other differentially expressed miRs and it appeared to be the main mediator of several TGFbeta signaling genes at initial and middle phases of differentiation. Integration studies further highlighted the involvement of TGFbeta pathway in the differentiation of OS cells towards osteoblasts and its regulation by microRNAs. These data underline that the expression of miR-34a and down

  8. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

    DEFF Research Database (Denmark)

    Kempf, Stefan J; Metaxas, Athanasios; Ibáñez-Vea, María

    2016-01-01

    The aim of this study was to elucidate the molecular signature of Alzheimer's disease-associated amyloid pathology.We used the double APPswe/PS1ΔE9 mouse, a widely used model of cerebral amyloidosis, to compare changes in proteome, including global phosphorylation and sialylated N-linked glycosyl...

  9. An integral analysis for second generation bioethanol production via a dynamic model-based simulation approach: stochastic nonlinear optimisation

    DEFF Research Database (Denmark)

    Morales Rodriguez, Ricardo; Meyer, Anne S.; Gernaey, Krist

    of cellulose, co-fermentation of sugars and downstream processes for purification and recovery of most value-added products. The dynamic model involves both the mass and energy balances coupled with constitutive dynamic equations to assess the process yield and energy efficiency of different bioethanol...

  10. CANDU plant life management - An integrated approach

    International Nuclear Information System (INIS)

    Hopkins, J.R.

    1998-01-01

    An integrated approach to plant life management has been developed for CANDU reactors. Strategies, methods, and procedures have been developed for assessment of critical systems structures and components and for implementing a reliability centred maintenance program. A Technology Watch program is being implemented to eliminate 'surprises'. Specific work has been identified for 1998. AECL is working on the integrated program with CANDU owners and seeks participation from other CANDU owners

  11. Toward an Integrative Model of Global Business Strategy

    DEFF Research Database (Denmark)

    Li, Xin

    fragmentation-integration-fragmentation-integration upward spiral. In response to the call for integrative approach to strategic management research, we propose an integrative model of global business strategy that aims at integrating not only strategy and IB but also the different paradigms within the strategy...

  12. Integrated Inflammatory Stress (ITIS) Model

    DEFF Research Database (Denmark)

    Bangsgaard, Elisabeth O.; Hjorth, Poul G.; Olufsen, Mette S.

    2017-01-01

    maintains a long-term level of the stress hormone cortisol which is also anti-inflammatory. A new integrated model of the interaction between these two subsystems of the inflammatory system is proposed and coined the integrated inflammatory stress (ITIS) model. The coupling mechanisms describing...

  13. The ABCDE-Model of counseling and psychotherapy: An integrative approach developed from clinical practice at a counseling service for students

    Directory of Open Access Journals (Sweden)

    Koutsoukou-Argyrak Asimina

    2016-01-01

    Full Text Available A comprehensive model of integrative psychotherapy that has been derived from clinical practice at the Counseling Service for Students of the University of Heidelberg is outlined. The ABCDE-model of integrative psychotherapy is based on established therapeutic methods and is composed of the dimensions of Alliance, Behavior, Cognitions, Dynamics and Existentials. Based on the therapeutic alliance and the general principles of understanding and communication, it comprises cognitive-behavioral, psychodynamic, and existential elements and employs hermeneutics as a meta-theoretical framework. The evaluation of integrative counseling according to the ABCDE-model in a naturalistic single-group pre-post design demonstrated a clinically significant improvement within a rather short number of sessions. Therefore, the integrative model of psychotherapy is an important contribution to evidence-based practice. Moreover, models of training in psychotherapy and counseling for the better education of future therapists can be developed on the basis of the ABCDE-model.

  14. Predicting Species-Resolved Macronutrient Acquisition during Succession in a Model Phototrophic Biofilm Using an Integrated ‘Omics Approach

    Energy Technology Data Exchange (ETDEWEB)

    Lindemann, Stephen R.; Mobberley, Jennifer M.; Cole, Jessica K.; Markillie, L. M.; Taylor, Ronald C.; Huang, Eric; Chrisler, William B.; Wiley, H. S.; Lipton, Mary S.; Nelson, William C.; Fredrickson, James K.; Romine, Margaret F.

    2017-06-13

    The principles governing acquisition and interspecies exchange of nutrients in microbial communities and how those exchanges impact community productivity are poorly understood. Here, we examine energy and macronutrient acquisition in unicyanobacterial consortia for which species-resolved genome information exists for all members, allowing us to use multi-omic approaches to predict species’ abilities to acquire resources and examine expression of resource-acquisition genes during succession. Metabolic reconstruction indicated that a majority of heterotrophic community members lacked the genes required to directly acquire the inorganic nutrients provided in culture medium, suggesting high metabolic interdependency. The sole primary producer in consortium UCC-O, cyanobacterium Phormidium sp. OSCR, displayed declining expression of energy harvest, carbon fixation, and nitrate and sulfate reduction proteins but sharply increasing phosphate transporter expression over 28 days. Most heterotrophic members likewise exhibited signs of phosphorus starvation during succession. Though similar in their responses to phosphorus limitation, heterotrophs displayed species-specific expression of nitrogen acquisition genes. These results suggest niche partitioning around nitrogen sources may structure the community when organisms directly compete for limited phosphate. Such niche complementarity around nitrogen sources may increase community diversity and productivity in phosphate-limited phototrophic communities.

  15. Predicting Species-Resolved Macronutrient Acquisition during Succession in a Model Phototrophic Biofilm Using an Integrated ‘Omics Approach

    Directory of Open Access Journals (Sweden)

    Stephen R. Lindemann

    2017-06-01

    Full Text Available The principles governing acquisition and interspecies exchange of nutrients in microbial communities and how those exchanges impact community productivity are poorly understood. Here, we examine energy and macronutrient acquisition in unicyanobacterial consortia for which species-resolved genome information exists for all members, allowing us to use multi-omic approaches to predict species’ abilities to acquire resources and examine expression of resource-acquisition genes during succession. Metabolic reconstruction indicated that a majority of heterotrophic community members lacked the genes required to directly acquire the inorganic nutrients provided in culture medium, suggesting high metabolic interdependency. The sole primary producer in consortium UCC-O, cyanobacterium Phormidium sp. OSCR, displayed declining expression of energy harvest, carbon fixation, and nitrate and sulfate reduction proteins but sharply increasing phosphate transporter expression over 28 days. Most heterotrophic members likewise exhibited signs of phosphorus starvation during succession. Though similar in their responses to phosphorus limitation, heterotrophs displayed species-specific expression of nitrogen acquisition genes. These results suggest niche partitioning around nitrogen sources may structure the community when organisms directly compete for limited phosphate. Such niche complementarity around nitrogen sources may increase community diversity and productivity in phosphate-limited phototrophic communities.

  16. INTEGRATION OF INPUT - OUTPUT APPROACH INTO AGENT-BASED MODELING. PART 2. INTERREGIONAL ANALYSIS IN AN ARTIFICIAL ECONOMY

    Directory of Open Access Journals (Sweden)

    Domozhirov D. A.

    2017-06-01

    Full Text Available The article demonstrates the possibilities of spatial analysis provided by the Agent-Based Multiregional Input - Output Model (ABMIOM of the Russian economy. The basic hypothesis of the ABMIOM is that agents’ decisions at the microeconomic level lead to spatial changes at the macro level. Confirmation of this hypothesis requires experimental calculations with changes in various parameters that influence agents’ decisions (such as prices, taxes, tariffs, etc.. Analyzing the results of these calculations requires moving from microeconomic data to the macro level. The paper proposes a method for the structural analysis of the model simulation results using input-output tables. The method involves statistical aggregation of calculation results, construction of regional, national and interregional input-output tables and structural analysis of the obtained tables including calculation of regional Leontief multipliers. The method proposed is used to study the influence of the level of transport costs on the geographical structure of trade flows. The results of the experiments confirmed that with the increase of transportation costs economic agents prefer to interact with nearest agents, which leads to a decreased interregional commodity exchange and to economic «insulation» of the regions.

  17. Integrability of the Rabi model.

    Science.gov (United States)

    Braak, D

    2011-09-02

    The Rabi model is a paradigm for interacting quantum systems. It couples a bosonic mode to the smallest possible quantum model, a two-level system. I present the analytical solution which allows us to consider the question of integrability for quantum systems that do not possess a classical limit. A criterion for quantum integrability is proposed which shows that the Rabi model is integrable due to the presence of a discrete symmetry. Moreover, I introduce a generalization with no symmetries; the generalized Rabi model is the first example of a nonintegrable but exactly solvable system.

  18. Technical Approach for Determining Key Parameters Needed for Modeling the Performance of Cast Stone for the Integrated Disposal Facility Performance Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Yabusaki, Steven B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Serne, R. Jeffrey [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rockhold, Mark L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wang, Guohui [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Westsik, Joseph H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-30

    Washington River Protection Solutions (WRPS) and its contractors at Pacific Northwest National Laboratory (PNNL) and Savannah River National Laboratory (SRNL) are conducting a development program to develop / refine the cementitious waste form for the wastes treated at the ETF and to provide the data needed to support the IDF PA. This technical approach document is intended to provide guidance to the cementitious waste form development program with respect to the waste form characterization and testing information needed to support the IDF PA. At the time of the preparation of this technical approach document, the IDF PA effort is just getting started and the approach to analyze the performance of the cementitious waste form has not been determined. Therefore, this document looks at a number of different approaches for evaluating the waste form performance and describes the testing needed to provide data for each approach. Though the approach addresses a cementitious secondary aqueous waste form, it is applicable to other waste forms such as Cast Stone for supplemental immobilization of Hanford LAW. The performance of Cast Stone as a physical and chemical barrier to the release of contaminants of concern (COCs) from solidification of Hanford liquid low activity waste (LAW) and secondary wastes processed through the Effluent Treatment Facility (ETF) is of critical importance to the Hanford Integrated Disposal Facility (IDF) total system performance assessment (TSPA). The effectiveness of cementitious waste forms as a barrier to COC release is expected to evolve with time. PA modeling must therefore anticipate and address processes, properties, and conditions that alter the physical and chemical controls on COC transport in the cementitious waste forms over time. Most organizations responsible for disposal facility operation and their regulators support an iterative hierarchical safety/performance assessment approach with a general philosophy that modeling provides

  19. Identifying multiple timescale rainfall controls on Mojave Desert ecohydrology using an integrated data and modeling approach for Larrea tridentata

    Science.gov (United States)

    Ng, Gene-Hua Crystal; Bedford, David R.; Miller, David M.

    2015-01-01

    The perennial shrub Larrea tridentata is widely successful in North American warm deserts but is also susceptible to climatic perturbations. Understanding its response to rainfall variability requires consideration of multiple timescales. We examine intra-annual to multi-year relationships using model simulations of soil moisture and vegetation growth over 50 years in the Mojave National Preserve in southeastern California (USA). Ecohydrological model parameters are conditioned on field and remote sensing data using an ensemble Kalman filter. Although no specific periodicities were detected in the rainfall record, simulated leaf-area-index exhibits multi-year dynamics that are driven by multi-year (∼3-years) rains, but with up to a 1-year delay in peak response. Within a multi-year period, Larrea tridentata is more sensitive to winter rains than summer. In the most active part of the root zone (above ∼80 cm), >1-year average soil moisture drives vegetation growth, but monthly average soil moisture is controlled by root uptake. Moisture inputs reach the lower part of the root zone (below ∼80 cm) infrequently, but once there they can persist over a year to help sustain plant growth. Parameter estimates highlight efficient plant physiological properties facilitating persistent growth and high soil hydraulic conductivity allowing deep soil moisture stores. We show that soil moisture as an ecological indicator is complicated by bidirectional interactions with vegetation that depend on timescale and depth. Under changing climate, Larrea tridentata will likely be relatively resilient to shorter-term moisture variability but will exhibit higher sensitivity to shifts in seasonal to multi-year moisture inputs.

  20. Identifying multiple time scale rainfall controls on Mojave Desert ecohydrology using an integrated data and modeling approach for Larrea tridentata

    Science.gov (United States)

    Ng, Gene-Hua Crystal; Bedford, David R.; Miller, David M.

    2015-06-01

    The perennial shrub Larrea tridentata is widely successful in North American warm deserts but is also susceptible to climatic perturbations. Understanding its response to rainfall variability requires consideration of multiple time scales. We examine intra-annual to multiyear relationships using model simulations of soil moisture and vegetation growth over 50 years in the Mojave National Preserve in southeastern California (USA). Ecohydrological model parameters are conditioned on field and remote sensing data using an ensemble Kalman filter. Although no specific periodicities were detected in the rainfall record, simulated leaf-area-index exhibits multiyear dynamics that are driven by multiyear (˜3 years) rains, but with up to a 1 year delay in peak response. Within a multiyear period, Larrea tridentata is more sensitive to winter rains than summer. In the most active part of the root zone (above ˜80 cm), >1 year average soil moisture drives vegetation growth, but monthly average soil moisture is controlled by root uptake. Moisture inputs reach the lower part of the root zone (below ˜80 cm) infrequently, but once there they can persist over a year to help sustain plant growth. Parameter estimates highlight efficient plant physiological properties facilitating persistent growth and high soil hydraulic conductivity allowing deep soil moisture stores. We show that soil moisture as an ecological indicator is complicated by bidirectional interactions with vegetation that depend on time scale and depth. Under changing climate, Larrea tridentata will likely be relatively resilient to shorter-term moisture variability but will exhibit higher sensitivity to shifts in seasonal to multiyear moisture inputs.

  1. Prediction of daily spring hydrographs for future climatic scenarios based on an integrated numerical modelling approach: Application on a snow-governed semi- arid karst catchment area.

    Science.gov (United States)

    Doummar, J.; Kassem, A.; Gurdak, J. J.

    2017-12-01

    In the framework of a three-year USAID/NSF- funded PEER Science project, flow in a karst system in Lebanon (Assal Spring; discharge 0.2-2.5 m3/s yearly volume of 22-30 Mm3) dominated by snow and semi arid conditions was simulated using an integrated numerical model (Mike She 2016). The calibrated model (Nash-Sutcliffe coefficient of 0.77) is based on high resolution input data (2014-2017) and detailed catchment characterization. The approach is to assess the influence of various model parameters on recharge signals in the different hydrological karst compartments (Atmosphere, unsaturated zone, and saturated zone) based on an integrated numerical model. These parameters include precipitation intensity and magnitude, temperature, snow-melt parameters, in addition to karst specific spatially distributed features such as fast infiltration points, soil properties and thickness, topographical slopes, Epikarst and thickness of unsaturated zone, and hydraulic conductivity among others. Moreover, the model is currently simulated forward using various scenarios for future climate (Global Climate Models GCM; daily downscaled temperature and precipitation time series for Lebanon 2020-2045) in order to depict the flow rates expected in the future and the effect of climate change on hydrographs recession coefficients, discharge maxima and minima, and total spring discharge volume . Additionally, a sensitivity analysis of individual or coupled major parameters allows quantifying their impact on recharge or indirectly on the vulnerability of the system (soil thickness, soil and rock hydraulic conductivity appear to be amongst the highly sensitive parameters). This study particularly unravels the normalized single effect of rain magnitude and intensity, snow, and temperature change on the flow rate (e.g., a change of temperature of 3° on the catchment yields a Residual Mean Square Error RMSE of 0.15 m3/s in the spring discharge and a 16% error in the total annual volume with

  2. Integrated Approach to Inform the New York City Water Supply System Coupling SAR Remote Sensing Observations and the SWAT Watershed Model

    Science.gov (United States)

    Tesser, D.; Hoang, L.; McDonald, K. C.

    2017-12-01

    Efforts to improve municipal water supply systems increasingly rely on an ability to elucidate variables that drive hydrologic dynamics within large watersheds. However, fundamental model variables such as precipitation, soil moisture, evapotranspiration, and soil freeze/thaw state remain difficult to measure empirically across large, heterogeneous watersheds. Satellite remote sensing presents a method to validate these spatially and temporally dynamic variables as well as better inform the watershed models that monitor the water supply for many of the planet's most populous urban centers. PALSAR 2 L-band, Sentinel 1 C-band, and SMAP L-band scenes covering the Cannonsville branch of the New York City (NYC) water supply watershed were obtained for the period of March 2015 - October 2017. The SAR data provides information on soil moisture, free/thaw state, seasonal surface inundation, and variable source areas within the study site. Integrating the remote sensing products with watershed model outputs and ground survey data improves the representation of related processes in the Soil and Water Assessment Tool (SWAT) utilized to monitor the NYC water supply. PALSAR 2 supports accurate mapping of the extent of variable source areas while Sentinel 1 presents a method to model the timing and magnitude of snowmelt runoff events. SMAP Active Radar soil moisture product directly validates SWAT outputs at the subbasin level. This blended approach verifies the distribution of soil wetness classes within the watershed that delineate Hydrologic Response Units (HRUs) in the modified SWAT-Hillslope. The research expands the ability to model the NYC water supply source beyond a subset of the watershed while also providing high resolution information across a larger spatial scale. The global availability of these remote sensing products provides a method to capture fundamental hydrology variables in regions where current modeling efforts and in situ data remain limited.

  3. Internal service quality by integrated approach Performance Control Matrix (PCM & Importance-Satisfaction Model (Studied in Yazd Regional Power Company

    Directory of Open Access Journals (Sweden)

    Saeid Peirow

    2016-02-01

    Full Text Available Today, the internal service quality as one of the most important factors affecting the recruitment and retention of staff is considered. The present study sought to examine the internal service quality of Yazd Regional Electric, finally, select appropriate strategies to improve the quality of local services in the organization. The application of this study is base on survey method.Data were collected from questionnaires to evaluate the 26 components of internal service quality of Yazd Regional Electric, has been used. Research community is the staff of the organisation.Also, the sample size, the initial questionnaire was distributed according to Cochran's formula is calculated.In order to analyze research data, the model is important - satisfaction and performance control matrix to identify those components that are used need to be improved.Also, in order to prioritize measures to improve employee satisfaction index is used. Data analysis using above tools show, 8 criteria are in improvment area. So, these criteria are prioritized with ESI.

  4. Advancing Instructional Communication: Integrating a Biosocial Approach

    Science.gov (United States)

    Horan, Sean M.; Afifi, Tamara D.

    2014-01-01

    Celebrating 100 years of the National Communication Association necessitates that, as we commemorate our past, we also look toward our future. As part of a larger conversation about the future of instructional communication, this essay reinvestigates the importance of integrating biosocial approaches into instructional communication research. In…

  5. Assessing the spatial representability of charcoal and PAH-based paleofire records with integrated GIS, modelling, and empirical approaches

    Science.gov (United States)

    Vachula, R. S.; Huang, Y.; Russell, J. M.

    2017-12-01

    Lake sediment-based fire reconstructions offer paleoenvironmental context in which to assess modern fires and predict future burning. However, despite the ubiquity, many uncertainties remain regarding the taphonomy of paleofire proxies and the spatial scales for which they record variations in fire history. Here we present down-core proxy analyses of polycyclic aromatic hydrocarbons (PAHs) and three size-fractions of charcoal (63-150, >150 and >250 μm) from Swamp Lake, California, an annually laminated lacustrine archive. Using a statewide historical GIS dataset of area burned, we assess the spatial scales for which these proxies are reliable recorders of fire history. We find that the coherence of observed and proxy-recorded fire history inherently depends upon spatial scale. Contrary to conventional thinking that charcoal mainly records local fires, our results indicate that macroscopic charcoal (>150 μm) may record spatially broader (250 μm) may be a more conservative proxy for local burning. We find that sub-macroscopic charcoal particles (63-150 μm) reliably record regional (up to 150 km) changes in fire history. These results indicate that charcoal-based fire reconstructions may represent spatially broader fire history than previously thought, which has major implications for our understanding of spatiotemporal paleofire variations. Our analyses of PAHs show that dispersal mobility is heterogeneous between compounds, but that PAH fluxes are reliable proxies of fire history within 25-50 km, which suggests PAHs may be a better spatially constrained paleofire proxy than sedimentary charcoal. Further, using a linear discriminant analysis model informed by modern emissions analyses, we show that PAH assemblages preserved in lake sediments can differentiate vegetation type burned, and are thus promising paleoecological biomarkers warranting further research and implementation. In sum, our analyses offer new insight into the spatial dimensions of paleofire

  6. Simulation of Sediment Yield in a Semi-Arid River Basin under Changing Land Use: An Integrated Approach of Hydrologic Modelling and Principal Component Analysis

    Directory of Open Access Journals (Sweden)

    Charles Gyamfi

    2016-11-01

    Full Text Available Intensified human activities over the past decades have culminated in the prevalence of dire environmental consequences of sediment yield resulting mainly from land use changes. Understanding the role that land use changes play in the dynamics of sediment yield would greatly enhance decision-making processes related to land use and water resources management. In this study, we investigated the impacts of land use and cover changes on sediment yield dynamics through an integrated approach of hydrologic modelling and principal component analysis (PCA. A three-phase land use scenario (2000, 2007 and 2013 employing the “fix-changing” method was used to simulate the sediment yield of the Olifants Basin. Contributions in the changes in individual land uses to sediment yield were assessed using the component and pattern matrixes of PCA. Our results indicate that sediment yield dynamics in the study area is significantly attributed to the changes in agriculture, urban and forested lands. Changes in agriculture and urban lands were directly proportional to sediment yield dynamics of the Olifants Basin. On the contrary, forested areas had a negative relationship with sediment yield indicating less sediment yield from these areas. The output of this research work provides a simplistic approach of evaluating the impacts of land use changes on sediment yield. The tools and methods used are relevant for policy directions on land and water resources planning and management.

  7. From Couple Therapy 1.0 to a Comprehensive Model: A Roadmap for Sequencing and Integrating Systemic, Psychodynamic, and Behavioral Approaches in Couple Therapy.

    Science.gov (United States)

    Nielsen, Arthur C

    2017-09-01

    Couple therapy is a complex undertaking that proceeds best by integrating various schools of thought. Grounded in an in-depth review of the clinical and research literature, and drawing on the author's 40-plus years of experience, this paper presents a comprehensive, flexible, and user-friendly roadmap for conducting couple therapy. It begins by describing "Couple Therapy 1.0," the basic conjoint couple therapy format in which partners talk to each other with the help of the therapist. After noting the limitations of this model, the paper introduces upgrades derived from systemic, psychodynamic, and behavioral/educational approaches, and shows how to combine and sequence them. The most important upgrade is the early focus on the couple's negative interaction cycle, which causes them pain and impedes their ability to address it. Using a clinical case example, the paper shows how all three approaches can improve couple process as a prerequisite for better problem solving. Additional modules and sequencing choice points are also discussed, including discernment counseling and encouraging positive couple experiences. © 2017 Family Process Institute.

  8. IMMIGRANTS’ INTEGRATION MODELS

    Directory of Open Access Journals (Sweden)

    CARMEN UZLĂU

    2012-05-01

    Full Text Available In the context of the European population aging trend, and while the birth rate is still at a low level, the immigrants may contribute to the support of the EU economy and to finance the national social protection systems. But this would be possible only if they have been fully integrated in the host countries, the integration policies being a task of the national governments. The European Union may still offer support and stimulation through financing, policies coordination and good practices exchange facilitation. The new measures should encourage local level actions, including cooperation between local authorities, employers, migrants’ organizations, service providers and local population. Within the EU, there live 20.1 million immigrants (approximately 4% of the entire population coming from outside European area. An important element of the common EU policy on immigration is the one regarding the development of a policy on immigrants’ integration, which should provide a fair treatment within the member states, and guarantee rights and obligations comparable with the ones of the Union citizens.

  9. Complementary and Integrative Approaches for Pediatric Headache.

    Science.gov (United States)

    Kedia, Sita

    2016-02-01

    In this article, the use of complementary and integrative medicine for the management of pediatric headache is reviewed. Despite limited numbers of studies for pediatric headaches, children and families seek these services. Integrative medicine focuses on treating the whole person, integrating conventional medicine with mind-body-spirit methods. Nutriceuticals include dietary supplements in the form of vitamins (vitamin D), minerals (magnesium), coenzyme Q, butterbur, and melatonin. Acupuncture, stimulation, physical therapy and Transcutaneous Electrical Nerve Stimulations (TENS) or Transcranial Magnetic Stimulation (TMS) may also be useful in selected patients. The efficacy of all these therapeutic alternatives in pediatric headache is presented here. Primary care providers, neurologists, and headache specialists alike need to be informed of such interventions and integrate these approaches, when appropriate, in the management of children with headaches. Copyright © 2016. Published by Elsevier Inc.

  10. Investigation of Geomorphic and Seismic Effects on the 1959 Madison Canyon, Montana, Landslide Using an Integrated Field, Engineering Geomorphology Mapping, and Numerical Modelling Approach

    Science.gov (United States)

    Wolter, A.; Gischig, V.; Stead, D.; Clague, J. J.

    2016-06-01

    We present an integrated approach to investigate the seismically triggered Madison Canyon landslide (volume = 20 Mm3), which killed 26 people in Montana, USA, in 1959. We created engineering geomorphological maps and conducted field surveys, long-range terrestrial digital photogrammetry, and preliminary 2D numerical modelling with the objective of determining the conditioning factors, mechanisms, movement behaviour, and evolution of the failure. We emphasise the importance of both endogenic (i.e. seismic) and exogenic (i.e. geomorphic) processes in conditioning the slope for failure and hypothesise a sequence of events based on the morphology of the deposit and seismic modelling. A section of the slope was slowly deforming before a magnitude-7.5 earthquake with an epicentre 30 km away triggered the catastrophic failure in August 1959. The failed rock mass rapidly fragmented as it descended the slope towards Madison River. Part of the mass remained relatively intact as it moved on a layer of pulverised debris. The main slide was followed by several debris slides, slumps, and rockfalls. The slide debris was extensively modified soon after the disaster by the US Army Corps of Engineers to provide a stable outflow channel from newly formed Earthquake Lake. Our modelling and observations show that the landslide occurred as a result of long-term damage of the slope induced by fluvial undercutting, erosion, weathering, and past seismicity, and due to the short-term triggering effect of the 1959 earthquake. Static models suggest the slope was stable prior to the 1959 earthquake; failure would have required a significant reduction in material strength. Preliminary dynamic models indicate that repeated seismic loading was a critical process for catastrophic failure. Although the ridge geometry and existing tension cracks in the initiation zone amplified ground motions, the most important factors in initiating failure were pre-existing discontinuities and seismically induced

  11. Integrating autonomous Problem Resolution Models with Remedy

    OpenAIRE

    Marquina, M A; Padilla, J; Ramos, R

    2000-01-01

    This paper briefly defines the concept of Problem Resolution Model and shows possible approaches to the issues which may arise when integrating various PRMs to present a consistent view to the end user, despite of the peculiarities of each physical implementation. Integration refers to various autonomous PRMs having to interact as problems pass from one to another in the resolution flow. This process should be transparent to the user and internally there must be a way to track in which stage ...

  12. An integrative approach to understanding bird origins.

    Science.gov (United States)

    Xu, Xing; Zhou, Zhonghe; Dudley, Robert; Mackem, Susan; Chuong, Cheng-Ming; Erickson, Gregory M; Varricchio, David J

    2014-12-12

    Recent discoveries of spectacular dinosaur fossils overwhelmingly support the hypothesis that birds are descended from maniraptoran theropod dinosaurs, and furthermore, demonstrate that distinctive bird characteristics such as feathers, flight, endothermic physiology, unique strategies for reproduction and growth, and a novel pulmonary system originated among Mesozoic terrestrial dinosaurs. The transition from ground-living to flight-capable theropod dinosaurs now probably represents one of the best-documented major evolutionary transitions in life history. Recent studies in developmental biology and other disciplines provide additional insights into how bird characteristics originated and evolved. The iconic features of extant birds for the most part evolved in a gradual and stepwise fashion throughout archosaur evolution. However, new data also highlight occasional bursts of morphological novelty at certain stages particularly close to the origin of birds and an unavoidable complex, mosaic evolutionary distribution of major bird characteristics on the theropod tree. Research into bird origins provides a premier example of how paleontological and neontological data can interact to reveal the complexity of major innovations, to answer key evolutionary questions, and to lead to new research directions. A better understanding of bird origins requires multifaceted and integrative approaches, yet fossils necessarily provide the final test of any evolutionary model. Copyright © 2014, American Association for the Advancement of Science.

  13. Integral, measure and derivative a unified approach

    CERN Document Server

    Shilov, G E

    2012-01-01

    This graduate-level textbook and monograph defines the functions of a real variable through consistent use of the Daniell scheme, offering a rare and useful alternative to customary approaches. The treatment can be understood by any reader with a solid background in advanced calculus, and it features many problems with hints and answers. ""The exposition is fresh and sophisticated,"" declared Sci-Tech Book News, ""and will engage the interest of accomplished mathematicians."" Part one is devoted to the integral, moving from the Reimann integral and step functions to a general theory, and obta

  14. Some Integral Inequalities Using Quantum Calculus Approach

    Directory of Open Access Journals (Sweden)

    Muhammad Uzair Awan

    2017-11-01

    Full Text Available The aim of this paper is to introduce a new class of preinvex functions which is called as generalized beta preinvex functions. We show that this class includes some other new classes of preinvex functions. We derive some new integral inequalities using the approach of quantum calculus. These integral inequalities involve generalized preinvex functions and q-Euler-Beta functions. Our results can be viewed as new quantum estimates for trapezoidal like inequalities. Some new special cases are also discussed which can be deduced from the main results of the paper.

  15. HEDR modeling approach

    International Nuclear Information System (INIS)

    Shipler, D.B.; Napier, B.A.

    1992-07-01

    This report details the conceptual approaches to be used in calculating radiation doses to individuals throughout the various periods of operations at the Hanford Site. The report considers the major environmental transport pathways--atmospheric, surface water, and ground water--and projects and appropriate modeling technique for each. The modeling sequence chosen for each pathway depends on the available data on doses, the degree of confidence justified by such existing data, and the level of sophistication deemed appropriate for the particular pathway and time period being considered

  16. Evaluating the latest estimates of spatially and temporally resolved gridded black carbon emission over Indian region in a strategic integrated modelling approach

    Science.gov (United States)

    Verma, S.; Kumar, B. D.; Reddy, M.

    2016-12-01

    Among aerosol constituents, black carbon (BC) has a strong mass absorption efficiency and play an important role in modifying the climate system. Regional and global modelling studies using BC emissions as input and simulating BC distribution in general exhibit large inadequacy compared to observations especially over regions where atmosphere is observed laden with high pollution level of BC concentration (e.g. the Indo-Gangetic plain, IGP over the Indian region); thereby indicating discrepancy in emissions. In the present study, we evaluate the latest spatially and temporally resolved gridded black carbon (BC) emissions estimated over Indian region in a strategic integrated modelling approach; this estimation was done extracting information on initial bottom-up monthly emissions and atmospheric BC concentration from a general circulation model (GCM) simulation in conjunction with receptor modelling approach. Monthly BC emission obtained from the present study exhibited a spatial and temporal variability with this being the highest (lowest) during February (July). Monthly BC emission flux was considerably high (> 100 Kg.Km-2) over the entire Indo-Gangetic plain (IGP) and the east coast during winter months with this high value, however, being persistent throughout over the northern IGP. This was relatively higher over the central and western India than over the IGP during summer months. Annual BC emission rate was 2568 Gg y-1with that over the IGP and central India respectively being 58% and 34% of the total annual BC emissions over India. The relative predominance of monthly BC emission flux over a region (as depicted from z-score distribution maps) was inferred being consistent with the prevalence of region- and season-specific anthropogenic activity. Evaluation of emissions (modified and old) through simulations in a chemical transport model showed the mean BC surface concentration simulated using modified emission resembled relatively well with the measured

  17. Modeling prosody: Different approaches

    Science.gov (United States)

    Carmichael, Lesley M.

    2002-11-01

    Prosody pervades all aspects of a speech signal, both in terms of raw acoustic outcomes and linguistically meaningful units, from the phoneme to the discourse unit. It is carried in the suprasegmental features of fundamental frequency, loudness, and duration. Several models have been developed to account for the way prosody organizes speech, and they vary widely in terms of their theoretical assumptions, organizational primitives, actual procedures of application to speech, and intended use (e.g., to generate speech from text vs. to model the prosodic phonology of a language). In many cases, these models overtly contradict one another with regard to their fundamental premises or their identification of the perceptible objects of linguistic prosody. These competing models are directly compared. Each model is applied to the same speech samples. This parallel analysis allows for a critical inspection of each model and its efficacy in assessing the suprasegmental behavior of the speech. The analyses illustrate how different approaches are better equipped to account for different aspects of prosody. Viewing the models and their successes from an objective perspective allows for creative possibilities in terms of combining strengths from models which might otherwise be considered fundamentally incompatible.

  18. Acquisition Integration Models: How Large Companies Successfully Integrate Startups

    Directory of Open Access Journals (Sweden)

    Peter Carbone

    2011-10-01

    Full Text Available Mergers and acquisitions (M&A have been popular means for many companies to address the increasing pace and level of competition that they face. Large companies have pursued acquisitions to more quickly access technology, markets, and customers, and this approach has always been a viable exit strategy for startups. However, not all deals deliver the anticipated benefits, in large part due to poor integration of the acquired assets into the acquiring company. Integration can greatly impact the success of the acquisition and, indeed, the combined company’s overall market success. In this article, I explore the implementation of several integration models that have been put into place by a large company and extract principles that may assist negotiating parties with maximizing success. This perspective may also be of interest to smaller companies as they explore exit options while trying to ensure continued market success after acquisition. I assert that business success with acquisitions is dependent on an appropriate integration model, but that asset integration is not formulaic. Any integration effort must consider the specific market context and personnel involved.

  19. Models and algorithms for Integration of Vehicle and Crew Scheduling

    NARCIS (Netherlands)

    R. Freling (Richard); D. Huisman (Dennis); A.P.M. Wagelmans (Albert)

    2000-01-01

    textabstractThis paper deals with models, relaxations and algorithms for an integrated approach to vehicle and crew scheduling. We discuss potential benefits of integration and provide an overview of the literature, which considers mainly partial integration. Our approach is new in the sense that we

  20. Small oilfield integrated production management model

    Directory of Open Access Journals (Sweden)

    Danilović Dušan

    2016-01-01

    Full Text Available In this paper is presented the concept of integrated oil production management model. The model's main objective is to provide more efficient tool for oil production process management in terms of the technological and economical aspects. Integrated oil production management model implies multidisciplinary approach which connects oil reservoir development and production with application of risk analysis. Model's task is to simulate behavior of the whole production system, enabling overcoming the weaknesses of conventional deterministic analysis and significantly enhancing oil production, as well as an investment decision making. In the article is presented shortly the application of integrated oil production management model at the oilfield 'K'. The ultimate goal was techno-economic analysis of managing production process, i.e. determination of production economic limit based on production history data, decline analysis and operating costs.

  1. Rethinking School Bullying: Towards an Integrated Model

    Science.gov (United States)

    Dixon, Roz; Smith, Peter K.

    2011-01-01

    What would make anti-bullying initiatives more successful? This book offers a new approach to the problem of school bullying. The question of what constitutes a useful theory of bullying is considered and suggestions are made as to how priorities for future research might be identified. The integrated, systemic model of school bullying introduced…

  2. Integrated Debugging of Modelica Models

    Directory of Open Access Journals (Sweden)

    Adrian Pop

    2014-04-01

    Full Text Available The high abstraction level of equation-based object-oriented (EOO languages such as Modelica has the drawback that programming and modeling errors are often hard to find. In this paper we present integrated static and dynamic debugging methods for Modelica models and a debugger prototype that addresses several of those problems. The goal is an integrated debugging framework that combines classical debugging techniques with special techniques for equation-based languages partly based on graph visualization and interaction. To our knowledge, this is the first Modelica debugger that supports both equation-based transformational and algorithmic code debugging in an integrated fashion.

  3. Learning Behavior and Achievement Analysis of a Digital Game-Based Learning Approach Integrating Mastery Learning Theory and Different Feedback Models

    Science.gov (United States)

    Yang, Kai-Hsiang

    2017-01-01

    It is widely accepted that the digital game-based learning approach has the advantage of stimulating students' learning motivation, but simply using digital games in the classroom does not guarantee satisfactory learning achievement, especially in the case of the absence of a teacher. Integrating appropriate learning strategies into a game can…

  4. PROJECT BASED ORGANIZATION - AN INTEGRATED APPROACH

    Directory of Open Access Journals (Sweden)

    Claudiu George BOCEAN

    2011-01-01

    Full Text Available As a consequence of globalization, application of new technologies, turbulent economic environment, the uncertainties affecting markets, organizations must cope with ongoing transformational process. In this context, the project-based organization (PBO emerges as an ideal alternative of organizational structure to deal with the emerging features of the temporary and unique demands, within a complex market. This paper brings a new approach trough integration of general management functions with project management activities. The methodology of the proposed ap-proach covers the whole Deming PDCA (Plan, Do, Check, Act cycle, involving quality management in project-based organization's success.

  5. Introduction to solid mechanics an integrated approach

    CERN Document Server

    Lubliner, Jacob

    2017-01-01

    This expanded second edition presents in one text the concepts and processes covered in statics and mechanics of materials curricula following a systematic, topically integrated approach. Building on the novel pedagogy of fusing concepts covered in traditional undergraduate courses in rigid-body statics and deformable body mechanics, rather than simply grafting them together, this new edition develops further the authors’ very original treatment of solid mechanics with additional figures, an elaboration on selected solved problems, and additional text as well as a new subsection on viscoelasticity in response to students’ feedback. Introduction to Solid Mechanics: An Integrated Approach, Second Edition, offers a holistic treatment of the depth and breadth of solid mechanics and the inter-relationships of its underlying concepts. Proceeding from first principles to applications, the book stands as a whole greater than the sum of its parts.  .

  6. Modeling Flood Hazard Zones at the Sub-District Level with the Rational Model Integrated with GIS and Remote Sensing Approaches

    Directory of Open Access Journals (Sweden)

    Daniel Asare-Kyei

    2015-07-01

    Full Text Available Robust risk assessment requires accurate flood intensity area mapping to allow for the identification of populations and elements at risk. However, available flood maps in West Africa lack spatial variability while global datasets have resolutions too coarse to be relevant for local scale risk assessment. Consequently, local disaster managers are forced to use traditional methods such as watermarks on buildings and media reports to identify flood hazard areas. In this study, remote sensing and Geographic Information System (GIS techniques were combined with hydrological and statistical models to delineate the spatial limits of flood hazard zones in selected communities in Ghana, Burkina Faso and Benin. The approach involves estimating peak runoff concentrations at different elevations and then applying statistical methods to develop a Flood Hazard Index (FHI. Results show that about half of the study areas fall into high intensity flood zones. Empirical validation using statistical confusion matrix and the principles of Participatory GIS show that flood hazard areas could be mapped at an accuracy ranging from 77% to 81%. This was supported with local expert knowledge which accurately classified 79% of communities deemed to be highly susceptible to flood hazard. The results will assist disaster managers to reduce the risk to flood disasters at the community level where risk outcomes are first materialized.

  7. Integrated Medical Model – Chest Injury Model

    Data.gov (United States)

    National Aeronautics and Space Administration — The Exploration Medical Capability (ExMC) Element of NASA's Human Research Program (HRP) developed the Integrated Medical Model (IMM) to forecast the resources...

  8. A new numerical approach to solve Thomas-Fermi model of an atom using bio-inspired heuristics integrated with sequential quadratic programming.

    Science.gov (United States)

    Raja, Muhammad Asif Zahoor; Zameer, Aneela; Khan, Aziz Ullah; Wazwaz, Abdul Majid

    2016-01-01

    In this study, a novel bio-inspired computing approach is developed to analyze the dynamics of nonlinear singular Thomas-Fermi equation (TFE) arising in potential and charge density models of an atom by exploiting the strength of finite difference scheme (FDS) for discretization and optimization through genetic algorithms (GAs) hybrid with sequential quadratic programming. The FDS procedures are used to transform the TFE differential equations into a system of nonlinear equations. A fitness function is constructed based on the residual error of constituent equations in the mean square sense and is formulated as the minimization problem. Optimization of parameters for the system is carried out with GAs, used as a tool for viable global search integrated with SQP algorithm for rapid refinement of the results. The design scheme is applied to solve TFE for five different scenarios by taking various step sizes and different input intervals. Comparison of the proposed results with the state of the art numerical and analytical solutions reveals that the worth of our scheme in terms of accuracy and convergence. The reliability and effectiveness of the proposed scheme are validated through consistently getting optimal values of statistical performance indices calculated for a sufficiently large number of independent runs to establish its significance.

  9. An approach to developing an integrated pyro processing simulator

    International Nuclear Information System (INIS)

    Lee, H.J.; Ko, I.W.; Choi, S.Y.; Kim, S.K.; Kim, I.T.; Lee, H.S.

    2013-01-01

    Full-text:Pyro processing has been studied for a decade as one of the promising fuel recycling options in Korea. We have built a pyro processing integrated inactive demonstration facility (PRIDE) to assess the feasibility of integrated pyro processing technology and scale-up issues of the processing equipment. Even though such facility cannot be replaced with a real integrated facility using spent nuclear fuel (SF), many insights can be obtained in terms of the worlds largest integrated pyro processing operation. In order to complement or overcome such limited test-based research, a pyro processing Modelling and simulation study began in 2011. The Korea Atomic Energy Research Institute (KAERI) suggested a Modelling architecture for the development of a multi-purpose pyro processing simulator consisting of three-tiered models: unit process, operation, and plant-level-model. The unit process model can be addressed using governing equations or empirical equations as a continuous system (CS). In contrast, the operation model describes the operational behaviors as a discrete event system (DES). The plant-level model is an integrated model of the unit process and an operation model with various analysis modules. An interface with different systems, the incorporation of different codes, a process-centered database design, and a dynamic material flow are discussed as necessary components for building a framework of the plant-level model. As a sample model that contains methods decoding the above engineering issues was thoroughly reviewed, the architecture for building the plant-level-model was verified. By analyzing a process and operation-combined model, we showed that the suggested approach is effective for comprehensively understanding an integrated dynamic material flow. This paper addressed the current status of the pyro processing Modelling and simulation activity at KAERI, and also predicted its path forward. (author)

  10. Efficient integration method for fictitious domain approaches

    Science.gov (United States)

    Duczek, Sascha; Gabbert, Ulrich

    2015-10-01

    In the current article, we present an efficient and accurate numerical method for the integration of the system matrices in fictitious domain approaches such as the finite cell method (FCM). In the framework of the FCM, the physical domain is embedded in a geometrically larger domain of simple shape which is discretized using a regular Cartesian grid of cells. Therefore, a spacetree-based adaptive quadrature technique is normally deployed to resolve the geometry of the structure. Depending on the complexity of the structure under investigation this method accounts for most of the computational effort. To reduce the computational costs for computing the system matrices an efficient quadrature scheme based on the divergence theorem (Gauß-Ostrogradsky theorem) is proposed. Using this theorem the dimension of the integral is reduced by one, i.e. instead of solving the integral for the whole domain only its contour needs to be considered. In the current paper, we present the general principles of the integration method and its implementation. The results to several two-dimensional benchmark problems highlight its properties. The efficiency of the proposed method is compared to conventional spacetree-based integration techniques.

  11. Modeling energy-economy interactions using integrated models

    International Nuclear Information System (INIS)

    Uyterlinde, M.A.

    1994-06-01

    Integrated models are defined as economic energy models that consist of several submodels, either coupled by an interface module, or embedded in one large model. These models can be used for energy policy analysis. Using integrated models yields the following benefits. They provide a framework in which energy-economy interactions can be better analyzed than in stand-alone models. Integrated models can represent both energy sector technological details, as well as the behaviour of the market and the role of prices. Furthermore, the combination of modeling methodologies in one model can compensate weaknesses of one approach with strengths of another. These advantages motivated this survey of the class of integrated models. The purpose of this literature survey therefore was to collect and to present information on integrated models. To carry out this task, several goals were identified. The first goal was to give an overview of what is reported on these models in general. The second one was to find and describe examples of such models. Other goals were to find out what kinds of models were used as component models, and to examine the linkage methodology. Solution methods and their convergence properties were also a subject of interest. The report has the following structure. In chapter 2, a 'conceptual framework' is given. In chapter 3 a number of integrated models is described. In a table, a complete overview is presented of all described models. Finally, in chapter 4, the report is summarized, and conclusions are drawn regarding the advantages and drawbacks of integrated models. 8 figs., 29 refs

  12. Integrated materials–structural models

    DEFF Research Database (Denmark)

    Stang, Henrik; Geiker, Mette Rica

    2008-01-01

    of structural modelling and materials concepts will both operational in both identifying important research issues and in answering the ‘real’ needs of society. Integrated materials-structural models will allow synergy to develop between materials and structural research. On one side the structural modelling......Reliable service life models for load carrying structures are significant elements in the evaluation of the performance and sustainability of existing and new structures. Furthermore, reliable service life models are prerequisites for the evaluation of the sustainability of maintenance strategies...... should define a framework in which materials research results eventually should fit in and on the other side the materials research should define needs and capabilities in structural modelling. Integrated materials-structural models of a general nature are almost non-existent in the field of cement based...

  13. The Integrated Curriculum Model (ICM)

    Science.gov (United States)

    VanTassel-Baska, Joyce; Wood, Susannah

    2010-01-01

    This article explicates the Integrated Curriculum Model (ICM) which has been used worldwide to design differentiated curriculum, instruction, and assessment units of study for gifted learners. The article includes a literature review of appropriate curriculum features for the gifted, other extant curriculum models, the theoretical basis for the…

  14. A Monte Carlo Approach to Modeling the Breakup of the Space Launch System EM-1 Core Stage with an Integrated Blast and Fragment Catalogue

    Science.gov (United States)

    Richardson, Erin; Hays, M. J.; Blackwood, J. M.; Skinner, T.

    2014-01-01

    The Liquid Propellant Fragment Overpressure Acceleration Model (L-FOAM) is a tool developed by Bangham Engineering Incorporated (BEi) that produces a representative debris cloud from an exploding liquid-propellant launch vehicle. Here it is applied to the Core Stage (CS) of the National Aeronautics and Space Administration (NASA) Space Launch System (SLS launch vehicle). A combination of Probability Density Functions (PDF) based on empirical data from rocket accidents and applicable tests, as well as SLS specific geometry are combined in a MATLAB script to create unique fragment catalogues each time L-FOAM is run-tailored for a Monte Carlo approach for risk analysis. By accelerating the debris catalogue with the BEi blast model for liquid hydrogen / liquid oxygen explosions, the result is a fully integrated code that models the destruction of the CS at a given point in its trajectory and generates hundreds of individual fragment catalogues with initial imparted velocities. The BEi blast model provides the blast size (radius) and strength (overpressure) as probabilities based on empirical data and anchored with analytical work. The coupling of the L-FOAM catalogue with the BEi blast model is validated with a simulation of the Project PYRO S-IV destruct test. When running a Monte Carlo simulation, L-FOAM can accelerate all catalogues with the same blast (mean blast, 2 s blast, etc.), or vary the blast size and strength based on their respective probabilities. L-FOAM then propagates these fragments until impact with the earth. Results from L-FOAM include a description of each fragment (dimensions, weight, ballistic coefficient, type and initial location on the rocket), imparted velocity from the blast, and impact data depending on user desired application. LFOAM application is for both near-field (fragment impact to escaping crew capsule) and far-field (fragment ground impact footprint) safety considerations. The user is thus able to use statistics from a Monte Carlo

  15. Evaluating the role of soil variability on groundwater pollution and recharge at regional scale by integrating a process-based vadose zone model in a stochastic approach

    Science.gov (United States)

    Coppola, Antonio; Comegna, Alessandro; Dragonetti, Giovanna; Lamaddalena, Nicola; Zdruli, Pandi

    2013-04-01

    modelling approaches have been developed at small space scales. Their extension to the applicative macroscale of the regional model is not a simple task mainly because of the heterogeneity of vadose zone properties, as well as of non-linearity of hydrological processes. Besides, one of the problems when applying distributed models is that spatial and temporal scales for data to be used as input in the models vary on a wide range of scales and are not always consistent with the model structure. Under these conditions, a strictly deterministic response to questions about the fate of a pollutant in the soil is impossible. At best, one may answer "this is the average behaviour within this uncertainty band". Consequently, the extension of these equations to account for regional-scale processes requires the uncertainties of the outputs be taken into account if the pollution vulnerability maps that may be drawn are to be used as agricultural management tools. A map generated without a corresponding map of associated uncertainties has no real utility. The stochastic stream tube approach is a frequently used to the water flux and solute transport through the vadose zone at applicative scales. This approach considers the field soil as an ensemble of parallel and statistically independent tubes, assuming only vertical flow. The stream tubes approach is generally used in a probabilistic framework. Each stream tube defines local flow properties that are assumed to vary randomly between the different stream tubes. Thus, the approach allows average water and solute behaviour be described, along with the associated uncertainty bands. These stream tubes are usually considered to have parameters that are vertically homogeneous. This would be justified by the large difference between the horizontal and vertical extent of the spatial applicative scale. Vertical is generally overlooked. Obviously, all the model outputs are conditioned by this assumption. The latter, in turn, is more dictated by

  16. An Integrated Hydrologic Model and Remote Sensing Synthesis Approach to Study Groundwater Extraction During a Historic Drought in the California Central Valley

    Science.gov (United States)

    Thatch, L. M.; Maxwell, R. M.; Gilbert, J. M.

    2017-12-01

    Over the past century, groundwater levels in California's San Joaquin Valley have dropped more than 30 meters in some areas due to excessive groundwater extraction to irrigate agricultural lands and feed a growing population. Between 2012 and 2016 California experienced the worst drought in its recorded history, further exacerbating this groundwater depletion. Due to lack of groundwater regulation, exact quantities of extracted groundwater in California are unknown and hard to quantify. We use a synthesis of integrated hydrologic model simulations and remote sensing products to quantify the impact of drought and groundwater pumping on the Central Valley water tables. The Parflow-CLM model was used to evaluate groundwater depletion in the San Joaquin River basin under multiple groundwater extraction scenarios simulated from pre-drought through recent drought years. Extraction scenarios included pre-development conditions, with no groundwater pumping; historical conditions based on decreasing groundwater level measurements; and estimated groundwater extraction rates calculated from the deficit between the predicted crop water demand, based on county land use surveys, and available surface water supplies. Results were compared to NASA's Gravity Recover and Climate Experiment (GRACE) data products to constrain water table decline from groundwater extraction during severe drought. This approach untangles various factors leading to groundwater depletion within the San Joaquin Valley both during drought and years of normal recharge to help evaluate which areas are most susceptible to groundwater overdraft, as well as further evaluating the spatially and temporally variable sustainable yield. Recent efforts to improve water management and ensure reliable water supplies are highlighted by California's Sustainable Groundwater Management Act (SGMA) which mandates Groundwater Sustainability Agencies to determine the maximum quantity of groundwater that can be withdrawn through

  17. Enabling model customization and integration

    Science.gov (United States)

    Park, Minho; Fishwick, Paul A.

    2003-09-01

    Until fairly recently, the idea of dynamic model content and presentation were treated synonymously. For example, if one was to take a data flow network, which captures the dynamics of a target system in terms of the flow of data through nodal operators, then one would often standardize on rectangles and arrows for the model display. The increasing web emphasis on XML, however, suggests that the network model can have its content specified in an XML language, and then the model can be represented in a number of ways depending on the chosen style. We have developed a formal method, based on styles, that permits a model to be specified in XML and presented in 1D (text), 2D, and 3D. This method allows for customization and personalization to exert their benefits beyond e-commerce, to the area of model structures used in computer simulation. This customization leads naturally to solving the bigger problem of model integration - the act of taking models of a scene and integrating them with that scene so that there is only one unified modeling interface. This work focuses mostly on customization, but we address the integration issue in the future work section.

  18. Quantum gravitation the Feynman path integral approach

    CERN Document Server

    Hamber, Herbert W

    2009-01-01

    The book covers the theory of Quantum Gravitation from the point of view of Feynman path integrals. These provide a manifestly covariant approach in which fundamental quantum aspects of the theory such as radiative corrections and the renormalization group can be systematically and consistently addressed. The path integral method is suitable for both perturbative as well as non-perturbative studies, and is known to already provide a framework of choice for the theoretical investigation of non-abelian gauge theories, the basis for three of the four known fundamental forces in nature. The book thus provides a coherent outline of the present status of the theory gravity based on Feynman’s formulation, with an emphasis on quantitative results. Topics are organized in such a way that the correspondence to similar methods and results in modern gauge theories becomes apparent. Covariant perturbation theory are developed using the full machinery of Feynman rules, gauge fixing, background methods and ghosts. The ren...

  19. Introduction to solid mechanics an integrated approach

    CERN Document Server

    Lubliner, Jacob

    2014-01-01

    This textbook presents for the first time in one text the concepts and processes covered in statics and mechanics of materials curricula following a systematic, topically integrated approach. Since the turn of the millennium, it has become common in engineering schools to combine the traditional undergraduate offerings in rigid-body statics (usually called “statics”) and deformable body mechanics (known traditionally as “strength of materials” or, more recently, “mechanics of materials”) into a single, introductory course in solid mechanics. Many textbooks for the new course sequentially meld pieces of existing, discrete books—sometimes, but not always, acknowledging the origin—into two halves covering Statics and Mechanics of Materials. In this volume, Professors Lubliner and Papadopoulos methodically combine the essentials of statics and mechanics of materials, illustrating the relationship of concepts throughout, into one "integrated" text. This book also: ·         Offers thorough...

  20. Integration of multi-omics techniques and physiological phenotyping within a holistic phenomics approach to study senescence in model and crop plants

    Czech Academy of Sciences Publication Activity Database

    Großkinsky, D.K.; Syaifullah, S. J.; Roitsch, Thomas

    2017-01-01

    Roč. 99, č. 99 (2017), s. 1-20 ISSN 0022-0957 R&D Projects: GA MŠk(CZ) LO1415 Institutional support: RVO:67179843 Keywords : integrated approaches * multi-omics * phenomics * plant development * plant–environment interactions * plant phenotyping * plant physiology * plant senescence * senescence programme * systems biology Subject RIV: EH - Ecology, Behaviour OBOR OECD: Environmental sciences (social aspects to be 5.7) Impact factor: 5.830, year: 2016

  1. An architecture for integration of multidisciplinary models

    DEFF Research Database (Denmark)

    Belete, Getachew F.; Voinov, Alexey; Holst, Niels

    2014-01-01

    , Enterprise Application Integration, and Integration Design Patterns. We developed an architecture of a multidisciplinary model integration framework that brings these three aspects of integration together. Service-oriented-based platform independent architecture that enables to establish loosely coupled...

  2. Integrated fluency instruction: Three approaches for working with struggling readers

    Directory of Open Access Journals (Sweden)

    Melanie Kuhn

    2014-11-01

    Full Text Available Effective fluency instruction should focus on reading with understanding, rather than simply reading quickly or expressively. This article outlines three research-based instructional approaches that assist students in developing accurate, automatic word recognition and prosody; at the same time, they ensure learners attend to the text’s meaning as they read. All three approaches integrate instructional principles known to improve reading fluency (modeling, scaffolding, repetition, and extensive opportunity for the reading of connected text. They are also clear and easy-to-implement and have proven successful with struggling readers. As a result, these approaches contribute to learners’ reading success both within and outside of the classroom.

  3. Integrated Fluency Instruction: Three Approaches for Working with Struggling Readers

    Directory of Open Access Journals (Sweden)

    Melanie KUHN

    2014-10-01

    Full Text Available Effective fluency instruction should focus on reading with understanding, rather than simply reading quickly or expressively. This article outlines three research-based instructional approaches that assist students in developing accurate, automatic word recognition and prosody; at the same time, they ensure learners attend to the text’s meaning as they read. All three approaches integrate instructional principles known to improve reading fluency (modeling, scaffolding, repetition, and extensive opportunity for the reading of connected text. They are also clear and easy-to-implement and have proven successful with struggling readers. As a result, these approaches contribute to learners’ reading success both within and outside of the classroom.

  4. Integrating new approaches to atrial fibrillation management

    DEFF Research Database (Denmark)

    Kotecha, Dipak; Breithardt, Günter; Camm, A John

    2018-01-01

    cardiovascular events. New approaches to AF management, including the use of novel technologies and structured, integrated care, have the potential to enhance clinical phenotyping or result in better treatment selection and stratified therapy. Here, we report the outcomes of the 6th Consensus Conference...... of the Atrial Fibrillation Network (AFNET) and the European Heart Rhythm Association (EHRA), held at the European Society of Cardiology Heart House in Sophia Antipolis, France, 17-19 January 2017. Sixty-two global specialists in AF and 13 industry partners met to develop innovative solutions based on new...

  5. An integrated process analytical technology (PAT) approach to monitoring the effect of supercooling on lyophilization product and process parameters of model monoclonal antibody formulations.

    Science.gov (United States)

    Awotwe Otoo, David; Agarabi, Cyrus; Khan, Mansoor A

    2014-07-01

    The aim of the present study was to apply an integrated process analytical technology (PAT) approach to control and monitor the effect of the degree of supercooling on critical process and product parameters of a lyophilization cycle. Two concentrations of a mAb formulation were used as models for lyophilization. ControLyo™ technology was applied to control the onset of ice nucleation, whereas tunable diode laser absorption spectroscopy (TDLAS) was utilized as a noninvasive tool for the inline monitoring of the water vapor concentration and vapor flow velocity in the spool during primary drying. The instantaneous measurements were then used to determine the effect of the degree of supercooling on critical process and product parameters. Controlled nucleation resulted in uniform nucleation at lower degrees of supercooling for both formulations, higher sublimation rates, lower mass transfer resistance, lower product temperatures at the sublimation interface, and shorter primary drying times compared with the conventional shelf-ramped freezing. Controlled nucleation also resulted in lyophilized cakes with more elegant and porous structure with no visible collapse or shrinkage, lower specific surface area, and shorter reconstitution times compared with the uncontrolled nucleation. Uncontrolled nucleation however resulted in lyophilized cakes with relatively lower residual moisture contents compared with controlled nucleation. TDLAS proved to be an efficient tool to determine the endpoint of primary drying. There was good agreement between data obtained from TDLAS-based measurements and SMART™ technology. ControLyo™ technology and TDLAS showed great potential as PAT tools to achieve enhanced process monitoring and control during lyophilization cycles. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  6. Material Modelling - Composite Approach

    DEFF Research Database (Denmark)

    Nielsen, Lauge Fuglsang

    1997-01-01

    This report is part of a research project on "Control of Early Age Cracking" - which, in turn, is part of the major research programme, "High Performance Concrete - The Contractor's Technology (HETEK)", coordinated by the Danish Road Directorate, Copenhagen, Denmark, 1997.A composite-rheological ......This report is part of a research project on "Control of Early Age Cracking" - which, in turn, is part of the major research programme, "High Performance Concrete - The Contractor's Technology (HETEK)", coordinated by the Danish Road Directorate, Copenhagen, Denmark, 1997.A composite......-rheological model of concrete is presented by which consistent predictions of creep, relaxation, and internal stresses can be made from known concrete composition, age at loading, and climatic conditions. No other existing "creep prediction method" offers these possibilities in one approach.The model...... in this report is that cement paste and concrete behave practically as linear-viscoelastic materials from an age of approximately 10 hours. This is a significant age extension relative to earlier studies in the literature where linear-viscoelastic behavior is only demonstrated from ages of a few days. Thus...

  7. APPROACH FOR IMPROVING THE INTEGRATED SENSOR ORIENTATION

    Directory of Open Access Journals (Sweden)

    E. Mitishita

    2016-06-01

    Full Text Available The direct determination of exterior orientation parameters (EOP of aerial images via integration of the Inertial Measurement Unit (IMU and GPS is often used in photogrammetric mapping nowadays. The accuracies of the EOP depend on the accurate parameters related to sensors mounting when the job is performed (offsets of the IMU relative to the projection centre and the angles of boresigth misalignment between the IMU and the photogrammetric coordinate system. In principle, when the EOP values do not achieve the required accuracies for the photogrammetric application, the approach, known as Integrated Sensor Orientation (ISO, is used to refine the direct EOP. ISO approach requires accurate Interior Orientation Parameters (IOP and standard deviation of the EOP under flight condition. This paper investigates the feasibility of use the in situ camera calibration to obtain these requirements. The camera calibration uses a small sub block of images, extracted from the entire block. A digital Vexcel UltraCam XP camera connected to APPLANIX POS AVTM system was used to get two small blocks of images that were use in this study. The blocks have different flight heights and opposite flight directions. The proposed methodology improved significantly the vertical and horizontal accuracies of the 3D point intersection. Using a minimum set of control points, the horizontal and vertical accuracies achieved nearly one image pixel of resolution on the ground (GSD. The experimental results are shown and discussed.

  8. Integrated Model of Bioenergy and Agriculture System

    DEFF Research Database (Denmark)

    Sigurjonsson, Hafthor Ægir; Elmegaard, Brian; Clausen, Lasse Røngaard

    2015-01-01

    approach that builds on Life Cycle Inventory and carries out Life Cycle Impact Assessment for a con- sequential Life Cycle Assessment on integrated bioenergy and agriculture systems. The model framework is built in Python which connects various freely available soft- ware that handle different aspects......Due to increased burden on the environment caused by human activities, focus on industrial ecology designs are gaining more attention. In that perspective an environ- mentally effective integration of bionergy and agriculture systems has significant potential. This work introduces a modeling...... of the overall model. C- TOOL and Yasso07 are used in the carbon balance of agri- culture, Dynamic Network Analysis is used for the energy simulation and Brightway2 is used to build a Life Cycle Inventory compatible database and processes it for vari- ous impacts assessment methods. The model is success- fully...

  9. Integration of a hygrothermal transfer model for envelope in a building energy simulation model: experimental validation of a HAM-BES co-simulation approach

    Science.gov (United States)

    Ferroukhi, M. Y.; Abahri, K.; Belarbi, R.; Limam, K.

    2017-06-01

    The present paper focuses on studying a new methodology to predict the overall behavior of buildings, which combines two simulation tools: COMSOL Multiphysicsand TRNSYS. The first software is used for the modeling of heat, air and moisture transfer in multilayer porous walls (HAM model—Heat, Air and Moisture transfer), and the second is used to simulate the hygrothermal behavior of the building (BES model—Building Energy Simulation). The combined software applications dynamically solve the mass and energy conservation equations of the two physical models. In this context, a coupled heat, air and mass transfer model is proposed. This model incorporates simultaneously the diffusive, convective and conductive effects on the building elements. Heat transfer is considered in the strongly coupled situation where the mass and heat flux are temperature, vapor pressure and total pressure dependents. The model input parameters are evaluated experimentally through the development of various experimental prototypes in the laboratory. Thereafter, an experimental setup has been established in order to evaluate the hygrothermal process of building walls. The experimental procedure consists to follow the temperature and relative humidity evolutions within the envelope thickness, submitted to controlled and fixed boundary conditions. Finally, using the developed experimental device, comparison between experimental data and numerical solution of the HAM-BES co-simulation platform was undertaken. Results showed good agreement with acceptable errors margins.

  10. Integrating a new traffic emissions model with an urban dispersion model: an innovative approach for urban transport policies assessment and air quality management

    International Nuclear Information System (INIS)

    Negrenti, E.; Zanini, G.; Kolarova, M.

    1999-01-01

    In the framework of the ESTEEM Project co-financed by the European Commission, an urban dispersion model (ADMS) has been applied for two sites in Rome with high topographic and traffic regimes complexity, where two air pollution monitoring stations are located. The traffic emissions values have been provided by TEE (Traffic Emissions and Energy) model developed at ENEA and based on a 'correction' of emissions calculated from average speed with a 'Kinematics Correction Factor' (KCF) which represents the speed variability along the link. This factor is derived as a function of link length, traffic density, link average speed and green time percentage at the traffic light. Hourly averaged CO concentrations have been calculated applying the ADMS model for the selected sites. The simulations were done using the meteorological conditions of 'real' days representative of the standard level of pollution in the season at the two sites, and compared with the measured pollution data. (Author)

  11. A design approach for integrating thermoelectric devices using topology optimization

    International Nuclear Information System (INIS)

    Soprani, S.; Haertel, J.H.K.; Lazarov, B.S.; Sigmund, O.; Engelbrecht, K.

    2016-01-01

    Highlights: • The integration of a thermoelectric (TE) cooler into a robotic tool is optimized. • Topology optimization is suggested as design tool for TE integrated systems. • A 3D optimization technique using temperature dependent TE properties is presented. • The sensitivity of the optimization process to the boundary conditions is studied. • A working prototype is constructed and compared to the model results. - Abstract: Efficient operation of thermoelectric devices strongly relies on the thermal integration into the energy conversion system in which they operate. Effective thermal integration reduces the temperature differences between the thermoelectric module and its thermal reservoirs, allowing the system to operate more efficiently. This work proposes and experimentally demonstrates a topology optimization approach as a design tool for efficient integration of thermoelectric modules into systems with specific design constraints. The approach allows thermal layout optimization of thermoelectric systems for different operating conditions and objective functions, such as temperature span, efficiency, and power recovery rate. As a specific application, the integration of a thermoelectric cooler into the electronics section of a downhole oil well intervention tool is investigated, with the objective of minimizing the temperature of the cooled electronics. Several challenges are addressed: ensuring effective heat transfer from the load, minimizing the thermal resistances within the integrated system, maximizing the thermal protection of the cooled zone, and enhancing the conduction of the rejected heat to the oil well. The design method incorporates temperature dependent properties of the thermoelectric device and other materials. The 3D topology optimization model developed in this work was used to design a thermoelectric system, complete with insulation and heat sink, that was produced and tested. Good agreement between experimental results and

  12. Integrated assessment of the global warming problem. A decision-analytical approach

    International Nuclear Information System (INIS)

    Van Lenthe, J.; Hendrickx, L.; Vlek, C.A.J.

    1995-01-01

    The project on the title subject aims at developing a policy-oriented methodology for the integrated assessment of the global warming problem. Decision analysis in general and influence diagrams in particular appear to constitute an appropriate integrated assessment methodology. The influence-diagram approach is illustrated at a preliminary integrated modeling of the global warming problem. In next stages of the research, attention will be shifted from the methodology of integrated assessment to the contents of integrated models. 4 figs., 5 refs

  13. A twistorial approach to integrability in N = 4 SYM

    Energy Technology Data Exchange (ETDEWEB)

    Koster, Laura; Mitev, Vladimir; Staudacher, Matthias [Institut fuer Mathematik, Institut fuer Physik und IRIS Adlershof, Humboldt-Universitaet Berlin (Germany)

    2015-02-01

    While the achievements in the study of N = 4 SYM Super Yang-Mills through the application of integrability are impressive, the precise origins of the exact solvability remain shrouded in mystery. In this note, we propose that viewing the problem through the lens of twistor theory should help to clarify the reasons for integrability. We illustrate the power of this approach by rederiving the model's one-loop spin chain dilatation operator in the SO(6) sector. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  14. 2. Gestaltdrama as an Integrative Psychotherapeutic Approach

    Directory of Open Access Journals (Sweden)

    Polínek Martin Dominik

    2016-03-01

    Full Text Available The following text is an overview study which defines the basic phenomena and effective factors of Gestalt drama and outlines some of the researches carried out in this area by the author during recent years. Gestalt drama is the name of a specific psychotherapeutic approach applied by the author in his practice, which combines Gestalt therapy with expressive approaches (especially with dramatherapy, theatrotherapy and fairytale-therapy. Linking Gestalt therapy and expressive techniques results in a specific psychotherapeutic approach whose versatility and holistic conception makes it suitable not only for psychotherapy but also for self-development of people with special needs, as it has the potential to meet the higher psychological needs even when the lower needs are not sufficiently saturated. The article further presents the interpretation of the partial results of research focusing on the analysis of integration performance where gestaltdrama techniques have been applied. These performances resulted from one-day dramatherapy workshops with clients suffering from mental retardation and with clients with behavioural disorders. This includes the analysis of differences between dramatical expression within the above target groups.

  15. Teaching psychodynamic psychotherapy to psychiatric residents: an integrated approach.

    Science.gov (United States)

    Gastelum, Emily; Douglas, Carolyn J; Cabaniss, Deborah L

    2013-03-01

    There is enduring controversy in our field regarding the place for supportive interventions in psychodynamic psychotherapy. This controversy is reflected in the differing ways in which psychodynamic psychotherapy has been conceptualized and taught in psychiatric residency training programs. The authors propose an "integrated" approach for teaching psychodynamic psychotherapy to trainees. In the integrated model, psychodynamic psychotherapy is conceptualized as a form of therapy designed to (a) uncover unconscious elements that influence thoughts, feelings, and behavior, and (b) support weakened psychological function. Using this model, residents learning psychodynamic psychotherapy are taught both uncovering and supporting techniques side by side in one course with specific guidelines for assessing when to use one set of interventions or the other. Teaching psychodynamic psychotherapy to residents in this integrated way prepares them to become skilled clinicians who are able to move fluidly from supporting to uncovering in a pragmatic and flexible manner, matched to the particular moment-to-moment needs of the individual patient.

  16. Modeling the effects of electrical and non-electrical parameters on the material removal and surface integrity in case of µEDM of a non-conductive ceramic material using a combined fuzzy-AOM approach

    DEFF Research Database (Denmark)

    Puthumana, Govindan

    2016-01-01

    Micro-EDM is a non-contact process based on the thermoelectric energy between a tool electrode and a workpiece. In μEDM process, the mechanism of material removal is melting and evaporation. The thermal energy in the discharge plasma helps remove material from the workpiece, at the same time...... deteriorates the quality and integrity of the workpiece surface. The material removal phenomenon in μEDM of partially conductive and non-conductive materials is very complex. This paper presents a novel approach to model the effects of electrical and non-electrical parameters on the material removal phenomenon...... and surface integrity for a non-conductive ceramic material. The fuzzy logic modeling system is employed for predicting the μEDM process responses. The trends in the material removal rate and hardness values with the chosen electrical and non-electrical parameter for the model and obtained using AOM approach...

  17. Permutation statistical methods an integrated approach

    CERN Document Server

    Berry, Kenneth J; Johnston, Janis E

    2016-01-01

    This research monograph provides a synthesis of a number of statistical tests and measures, which, at first consideration, appear disjoint and unrelated. Numerous comparisons of permutation and classical statistical methods are presented, and the two methods are compared via probability values and, where appropriate, measures of effect size. Permutation statistical methods, compared to classical statistical methods, do not rely on theoretical distributions, avoid the usual assumptions of normality and homogeneity of variance, and depend only on the data at hand. This text takes a unique approach to explaining statistics by integrating a large variety of statistical methods, and establishing the rigor of a topic that to many may seem to be a nascent field in statistics. This topic is new in that it took modern computing power to make permutation methods available to people working in the mainstream of research. This research monograph addresses a statistically-informed audience, and can also easily serve as a ...

  18. Path-integral approach to resonant electron-molecule scattering

    International Nuclear Information System (INIS)

    Winterstetter, M.; Domcke, W.

    1993-01-01

    A path-integral formulation of resonant electron-molecule scattering is developed within the framework of the projection-operator formalism of scattering theory. The formation and decay of resonances is treated in real time as a quantum-mechanical electronic-tunneling process, modified by the coupling of the electronic motion with the nuclear degrees of freedom. It is shown that the electronic continuum can be summed over in the path-integral formulation, resulting formally in the path integral for an effective two-state system with coupling to vibrations. The harmonic-oscillator approximation is adopted for the vibrational motion in the present work. Approximation methods are introduced which render the numerical evaluation of the sum over paths feasible for up to ∼10 3 elementary time slices. The theory is numerically realized for simple but nontrivial models representing the 2 Π g d-wave shape resonance in e - +N 2 collisions and the 2 Σ u + p-wave shape resonance in e - +H 2 collisions, respectively. The accuracy of the path-integral results is assessed by comparison with exact numerical reference data for these models. The essential virtue of the path-integral approach is the fact that the computational effort scales at most linearly with the number of vibrational degrees of freedom. The path-integral method is thus well suited to treat electron collisions with polyatomic molecules and molecular aggregates

  19. Path integral for spin: A new approach

    International Nuclear Information System (INIS)

    Aliev, T.M.; Fainberg, V.Ya.; Pak, N.K.

    1994-01-01

    The path integral representation for the propagator of a Dirac particle in an external electromagnetic field is derived using the functional derivative formalism with the help of Weyl symbol representation for the Grassmann vector part of the variables. The proposed method simplifies the proof of the path integral representation starting from the equation for the Green function significantly and automatically leads to a precise and unambiguous set of boundary conditions for the anticommuting variables and puts strong restrictions on the choice of the gauge conditions. The same problem is reconsidered using the Polyakov and Batalin-Fradkin-Vilkovisky methods together with the Weyl symbol method and it is shown to yield the same PIR. It is shown that in the last case, the non-trivial first class constraints algebra for a Dirac particle plays an important role in the derivation, and this algebra is the limiting case of the superconformal algebra for a Ramond open string when the width goes to zero. That the approach proposed here can be applied to any point-like particle is illustrated in the propagator for the nonrelativistic Pauli spinning particle in an external electromagnetic field. ((orig.))

  20. Model-Driven and Pattern-Based Integration of Process-Driven SOA Models

    OpenAIRE

    Zdun, Uwe; Dustdar, Schahram

    2006-01-01

    Service-oriented architectures (SOA) are increasingly used in the context of business processes. However, the modeling approaches for process-driven SOAs do not yet sufficiently integrate the various kinds of models relevant for a process-driven SOA -- ranging from process models to software architectural models to software design models. We propose to integrate process-driven SOA models via a model-driven software development approach that is based on proven practices do...

  1. Integrating Seasonal Oscillations into Basel II Behavioural Scoring Models

    Directory of Open Access Journals (Sweden)

    Goran Klepac

    2007-09-01

    Full Text Available The article introduces a new methodology of temporal influence measurement (seasonal oscillations, temporal patterns for behavioural scoring development purposes. The paper shows how significant temporal variables can be recognised and then integrated into the behavioural scoring models in order to improve model performance. Behavioural scoring models are integral parts of the Basel II standard on Internal Ratings-Based Approaches (IRB. The IRB approach much more precisely reflects individual risk bank profile.A solution of the problem of how to analyze and integrate macroeconomic and microeconomic factors represented in time series into behavioural scorecard models will be shown in the paper by using the REF II model.

  2. Model-integrating software components engineering flexible software systems

    CERN Document Server

    Derakhshanmanesh, Mahdi

    2015-01-01

    In his study, Mahdi Derakhshanmanesh builds on the state of the art in modeling by proposing to integrate models into running software on the component-level without translating them to code. Such so-called model-integrating software exploits all advantages of models: models implicitly support a good separation of concerns, they are self-documenting and thus improve understandability and maintainability and in contrast to model-driven approaches there is no synchronization problem anymore between the models and the code generated from them. Using model-integrating components, software will be

  3. Mobile impurities in integrable models

    Directory of Open Access Journals (Sweden)

    Andrew S. Campbell, Dimitri M. Gangardt

    2017-08-01

    Full Text Available We use a mobile impurity or depleton model to study elementary excitations in one-dimensional integrable systems. For Lieb-Liniger and bosonic Yang-Gaudin models we express two phenomenological parameters characterising renormalised inter- actions of mobile impurities with superfluid background: the number of depleted particles, $N$ and the superfluid phase drop $\\pi J$ in terms of the corresponding Bethe Ansatz solution and demonstrate, in the leading order, the absence of two-phonon scattering resulting in vanishing rates of inelastic processes such as viscosity experienced by the mobile impurities

  4. Exclusion statistics and integrable models

    International Nuclear Information System (INIS)

    Mashkevich, S.

    1998-01-01

    The definition of exclusion statistics that was given by Haldane admits a 'statistical interaction' between distinguishable particles (multispecies statistics). For such statistics, thermodynamic quantities can be evaluated exactly; explicit expressions are presented here for cluster coefficients. Furthermore, single-species exclusion statistics is realized in one-dimensional integrable models of the Calogero-Sutherland type. The interesting questions of generalizing this correspondence to the higher-dimensional and the multispecies cases remain essentially open; however, our results provide some hints as to searches for the models in question

  5. The integrated environmental control model

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, E.S.; Berkenpas, M.B.; Kalagnanam, J.R. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    1995-11-01

    The capability to estimate the performance and cost of emission control systems is critical to a variety of planning and analysis requirements faced by utilities, regulators, researchers and analysts in the public and private sectors. The computer model described in this paper has been developed for DOe to provide an up-to-date capability for analyzing a variety of pre-combustion, combustion, and post-combustion options in an integrated framework. A unique capability allows performance and costs to be modeled probabilistically, which allows explicit characterization of uncertainties and risks.

  6. Science of Integrated Approaches to Natural Resources Management

    Science.gov (United States)

    Tengberg, Anna; Valencia, Sandra

    2017-04-01

    transitions towards sustainable management of natural resources should be harnessed and integrated into GEF's influencing models and theory of change, and be coupled with updated approaches for learning, adaptive management and scaling up.

  7. Integrated Site Model Process Model Report

    International Nuclear Information System (INIS)

    Booth, T.

    2000-01-01

    The Integrated Site Model (ISM) provides a framework for discussing the geologic features and properties of Yucca Mountain, which is being evaluated as a potential site for a geologic repository for the disposal of nuclear waste. The ISM is important to the evaluation of the site because it provides 3-D portrayals of site geologic, rock property, and mineralogic characteristics and their spatial variabilities. The ISM is not a single discrete model; rather, it is a set of static representations that provide three-dimensional (3-D), computer representations of site geology, selected hydrologic and rock properties, and mineralogic-characteristics data. These representations are manifested in three separate model components of the ISM: the Geologic Framework Model (GFM), the Rock Properties Model (RPM), and the Mineralogic Model (MM). The GFM provides a representation of the 3-D stratigraphy and geologic structure. Based on the framework provided by the GFM, the RPM and MM provide spatial simulations of the rock and hydrologic properties, and mineralogy, respectively. Functional summaries of the component models and their respective output are provided in Section 1.4. Each of the component models of the ISM considers different specific aspects of the site geologic setting. Each model was developed using unique methodologies and inputs, and the determination of the modeled units for each of the components is dependent on the requirements of that component. Therefore, while the ISM represents the integration of the rock properties and mineralogy into a geologic framework, the discussion of ISM construction and results is most appropriately presented in terms of the three separate components. This Process Model Report (PMR) summarizes the individual component models of the ISM (the GFM, RPM, and MM) and describes how the three components are constructed and combined to form the ISM

  8. SPATIAL DATA INTEGRATION USING ONTOLOGY-BASED APPROACH

    Directory of Open Access Journals (Sweden)

    S. Hasani

    2015-12-01

    Full Text Available In today's world, the necessity for spatial data for various organizations is becoming so crucial that many of these organizations have begun to produce spatial data for that purpose. In some circumstances, the need to obtain real time integrated data requires sustainable mechanism to process real-time integration. Case in point, the disater management situations that requires obtaining real time data from various sources of information. One of the problematic challenges in the mentioned situation is the high degree of heterogeneity between different organizations data. To solve this issue, we introduce an ontology-based method to provide sharing and integration capabilities for the existing databases. In addition to resolving semantic heterogeneity, better access to information is also provided by our proposed method. Our approach is consisted of three steps, the first step is identification of the object in a relational database, then the semantic relationships between them are modelled and subsequently, the ontology of each database is created. In a second step, the relative ontology will be inserted into the database and the relationship of each class of ontology will be inserted into the new created column in database tables. Last step is consisted of a platform based on service-oriented architecture, which allows integration of data. This is done by using the concept of ontology mapping. The proposed approach, in addition to being fast and low cost, makes the process of data integration easy and the data remains unchanged and thus takes advantage of the legacy application provided.

  9. Theory and Practice: An Integrative Model Linking Class and Field

    Science.gov (United States)

    Lesser, Joan Granucci; Cooper, Marlene

    2006-01-01

    Social work has evolved over the years taking on the challenges of the times. The profession now espouses a breadth of theoretical approaches and treatment modalities. We have developed a model to help graduate social work students master the skill of integrating theory and social work practice. The Integrative Model has five components: (l) The…

  10. Cotangent Models for Integrable Systems

    Science.gov (United States)

    Kiesenhofer, Anna; Miranda, Eva

    2017-03-01

    We associate cotangent models to a neighbourhood of a Liouville torus in symplectic and Poisson manifolds focusing on b-Poisson/ b-symplectic manifolds. The semilocal equivalence with such models uses the corresponding action-angle theorems in these settings: the theorem of Liouville-Mineur-Arnold for symplectic manifolds and an action-angle theorem for regular Liouville tori in Poisson manifolds (Laurent- Gengoux et al., IntMath Res Notices IMRN 8: 1839-1869, 2011). Our models comprise regular Liouville tori of Poisson manifolds but also consider the Liouville tori on the singular locus of a b-Poisson manifold. For this latter class of Poisson structures we define a twisted cotangent model. The equivalence with this twisted cotangent model is given by an action-angle theorem recently proved by the authors and Scott (Math. Pures Appl. (9) 105(1):66-85, 2016). This viewpoint of cotangent models provides a new machinery to construct examples of integrable systems, which are especially valuable in the b-symplectic case where not many sources of examples are known. At the end of the paper we introduce non-degenerate singularities as lifted cotangent models on b-symplectic manifolds and discuss some generalizations of these models to general Poisson manifolds.

  11. Integrated Transport Planning Framework Involving Combined Utility Regret Approach

    DEFF Research Database (Denmark)

    Wang, Yang; Monzon, Andres; Di Ciommo, Floridea

    2014-01-01

    in a framework for integrated transport planning. The framework consisted of a two-round Delphi survey, integrated land use and transport model for Madrid, and multicriteria analysis. Results show that (a) the regret-based ranking has a similar mean but larger variance than the utility-based ranking does, (b......Sustainable transport planning requires an integrated approach involving strategic planning, impact analysis, and multicriteria evaluation. This study aimed at relaxing the utility-based decision-making assumption by newly embedding anticipated-regret and combined utility regret decision mechanisms......-based multicriteria analyses result in different rankings of policy packages, and (e) the combined utility regret ranking is more informative compared with the utility-based or the regret-based ranking....

  12. Drugs of Abuse and Addiction: An integrated approach to teaching.

    Science.gov (United States)

    Miller, Lindsey N; Mercer, Susan L

    2017-05-01

    To describe the design, implementation, and student perceptions of a Drugs of Abuse and Addiction elective course utilizing an integrated teaching model. Third-year pharmacy students enrolled in the two credit hour elective. Teaching methodology included didactic lecture, journal club, simulated addiction assignment with reflection, debates, external speakers, site visit to a residential drug court program and research paper with presentation. A course objective survey was administered upon course completion. All students strongly agreed that having science- and clinical-based faculty members develop and deliver course content was beneficial. Additionally, all students agree to strongly agree that their research project helped them integrate and comprehend the science and practice surrounding drugs of abuse and addiction. Students enjoyed an integrated teaching approach and multiple teaching methodologies leading to increased engagement and enhancement of student learning. Course enrollment was beneficial for personalized learning, but limited student perspective. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Science based integrated approach to advanced nuclear fuel development - vision, approach, and overview

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Laboratory; Pasamehmetoglu, Kemal [IDAHO NATIONAL LAB; Carmack, Jon [IDAHO NATIONAL LAB

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Rcactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems is critical. In order to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. The purpose of this paper is to identify the modeling and simulation approach in order to deliver predictive tools for advanced fuels development. The coordination between experimental nuclear fuel design, development technical experts, and computational fuel modeling and simulation technical experts is a critical aspect of the approach and naturally leads to an integrated, goal-oriented science-based R & D approach and strengthens both the experimental and computational efforts. The Advanced Fuels Campaign (AFC) and Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Integrated Performance and Safety Code (IPSC) are working together to determine experimental data and modeling needs. The primary objective of the NEAMS fuels IPSC project is to deliver a coupled, three-dimensional, predictive computational platform for modeling the fabrication and both normal and abnormal operation of nuclear fuel pins and assemblies, applicable to both existing and future reactor fuel designs. The science based program is pursuing the development of an integrated multi-scale and multi-physics modeling and simulation platform for nuclear fuels. This overview paper discusses the vision, goals and approaches how to develop and implement the new approach.

  14. Integrated reporting: A new approach to corporate reporting and management

    Directory of Open Access Journals (Sweden)

    Prošić Danica

    2015-01-01

    Full Text Available Integrated reporting is an opportunity to present a comprehensive picture of one's business in a clear, concise, coherent and comparable way. The idea of an integrated reporting and integration with non-financial data in the annual reports has many advantages and benefits compared to the current model of corporate reporting. Such approach enables us to consider the material issues facing our business and the community, and show how we create value for shareholders and society as a whole. At the same time, it also poses many new challenges, dilemmas and issues, at both accounting and managerial level. Among the key issues are those related to standards of reporting on non-financial aspects of business, methods of integrating financial and non- financial data and encouraging management to opt for modern and balanced reporting concept oriented towards the future, when the model is still being improved. Integrated reporting will be on the agenda of those companies in which top managers have recognized and understood the tangible benefits and sophistication of corporate reporting.

  15. Integration of Artificial Neural Network Modeling and Genetic Algorithm Approach for Enrichment of Laccase Production in Solid State Fermentation by Pleurotus ostreatus

    OpenAIRE

    Potu Venkata Chiranjeevi; Moses Rajasekara Pandian; Sathish Thadikamala

    2014-01-01

    Black gram husk was used as a solid substrate for laccase production by Pleurotus ostreatus, and various fermentation conditions were optimized based on an artificial intelligence method. A total of six parameters, i.e., temperature, inoculum concentration, moisture content, CuSO4, glucose, and peptone concentrations, were optimized. A total of 50 experiments were conducted, and the obtained data were modeled by a hybrid of artificial neural network (ANN) and genetic algorithm (GA) approaches...

  16. Integrating bioavailability approaches into waste rock evaluations

    Science.gov (United States)

    Ranville, James F.; Blumenstein, E. P.; Adams, Michael J.; Choate, LaDonna M.; Smith, Kathleen S.; Wildeman, Thomas R.

    2006-01-01

    The presence of toxic metals in soils affected by mining, industry, agriculture and urbanization, presents problems to human health, the establishment and maintenance of plant and animal habitats, and the rehabilitation of affected areas. A key to managing these problems is predicting the fraction of metal in a given soil that will be biologically labile, and potentially harmful ('bioavailable'). The molecular form of metals and metalloids, particularly the uncomplexed (free) form, controls their bioavailability and toxicity in solution. One computational approach for determining bioavailability, the biotic ligand model (BLM), takes into account not only metal complexation by ligands in solution, but also competitive binding of hardness cations (Ca 2+,Mg 2+,) and metal ions to biological receptor sites. The more direct approach to assess bioavailability is to explicitly measure the response of an organism to a contaminant. A number of microbial enzyme tests have been developed to assess the impact of pollution in a rapid and procedurally simple way. These different approaches in making bioavailability predictions may have value in setting landuse priorities, remediation goals, and habitat reclamation strategies.

  17. An integral approach to corporate environmentalism and its application to a country in transition

    DEFF Research Database (Denmark)

    Prašnikar, J.; Ograjenšek, I.; Pahor, M.

    2012-01-01

    In this paper we propose and implement an integral approach to corporate environmentalism. Our integral model accounts not only for corporate environmentalism motivation and conception but also for corporate environmentalism mode and speed of implementation. A broad range of identified corporate...... sample of Slovenian manufacturing companies. Maximum likelihood probit estimation, exploratory factor analysis, cluster analysis and binary logistic modeling are used in the empirical analysis. Our main conclusions are twofold: (1) The integral approach to corporate environmentalism works...

  18. Search of novel model for integrative medicine.

    Science.gov (United States)

    Patwardhan, Bhushan; Mutalik, Gururaj

    2014-03-01

    This article provides global and Indian scenario with strengths and limitations of present health care system. Affordability, accessibility and availability of health care coupled with disproportionate growth and double burden of diseases have become major concerns in India. This article emphasizes need for mindset change from illness-disease-drug centric curative to person-health-wellness centric preventive and promotive approaches. It highlights innovation deficit faced pharmaceutical industry and drugs being withdrawn from market for safety reasons. Medical pluralism is a growing trend and people are exploring various options including modern, traditional, complementary and alternative medicine. In such a situation, knowledge from Ayurveda, yoga, Chinese medicine and acupuncture may play an important role. We can evolve a suitable model by integrating modern and traditional systems of medicine for affordable health care. In the larger interest of global community, Indian and Chinese systems should share knowledge and experiences for mutual intellectual enrichments and work together to evolve a novel model of integrative medicine.

  19. Modeling of critical factors for integrating sustainability with innovation for Indian small- and medium-scale manufacturing enterprises: An ISM and MICMAC approach

    Directory of Open Access Journals (Sweden)

    Bisma Mannan

    2016-12-01

    Full Text Available The growth of any country depends upon the existence of small- and medium-scale enterprises (SMEs. The greater the number of SMEs present in any country, the economy of the country increases in the same proportion. This paper uses the qualitative research technique to study the critical factors which affect the integration of sustainability with innovation taking into account Indian manufacturing SMEs. An ISM approach is applied to establish the interrelationship between the various critical factors. And with the help of Fuzzy Micmac technique, driver dependence power diagraph is created. From our analysis, it has been found that “government regulation” has the highest dominating power which helps in successful execution of integrating sustainability with innovation. Variables “employee nature” and “working culture” have the highest dependence power. The success of these variables depends on the success of the variables below them. Finally, the limitations of using the above techniques are discussed and then the suggestions are made for the further research.

  20. Integrated modelling in materials and process technology

    DEFF Research Database (Denmark)

    Hattel, Jesper Henri

    2008-01-01

    Integrated modelling of entire process sequences and the subsequent in-service conditions, and multiphysics modelling of the single process steps are areas that increasingly support optimisation of manufactured parts. In the present paper, three different examples of modelling manufacturing...... processes from the viewpoint of combined materials and process modelling are presented: solidification of thin walled ductile cast iron, integrated modelling of spray forming and multiphysics modelling of friction stir welding. The fourth example describes integrated modelling applied to a failure analysis...

  1. An integrated approach of analytical chemistry

    Directory of Open Access Journals (Sweden)

    Guardia Miguel de la

    1999-01-01

    Full Text Available The tremendous development of physical methods of analysis offers an impressive number of tools to simultaneously determine a large number of elements and compounds at very low concentration levels. Todays Analytical Chemistry provides appropriate media to solve technical problems and to obtain correct information about chemical systems in order to take the most appropriate decisions for problem solving. In recent years the development of new strategies for sampling, sample treatment and data exploitation through the research on field sampling, microwaveassisted procedures and chemometrics, additionally the revolution of the analytical methodology provided by the development of flow analysis concepts and process analysis strategies offer a link between modern instrumentation and social or technological problems. The integrated approach of Analytical Chemistry requires correctly incorporating the developments in all of the fields of both, basic chemistry, instrumentation and information theory, in a scheme which considers all aspects of data obtention and interpretation taking also into consideration the side effects of chemical measurements. In this paper, new ideas and tools for trace analysis, speciation, surface analysis, data acquisition and data treatment, automation and decontamination, are presented in the frame of Analytical Chemistry as a problem solving strategy focused on the chemical composition of systems and on the specific figures of merit of the analytical measurements, like accuracy, precision, sensitivity, selectivity but also speed and cost. Technological and industrial, but also environmental, health and social problems, have been considered as challenges for which solution the chemist should select the most appropriate tool and to develop an appropriate strategy.

  2. Nuclear power programme planning: An integrated approach

    International Nuclear Information System (INIS)

    2001-12-01

    The International Atomic Energy Agency (IAEA) has published material on different policy considerations in the introduction of nuclear power, primarily addressed to top level decision makers in government and industry in Member States. Several Member States and experts recommended to the IAEA to address the aspects of an integrated approach to nuclear power programme planning and to serve as guidance to those countries wishing to embark on a nuclear power programme. As a follow-up, the present publication is primarily intended to serve as guidance for executives and managers in Member States in planning for possible introduction of nuclear power plants in their electricity generating systems. Nuclear power programme planning, as dealt with in this publication, includes all activities that need to be carried out up to a well-founded decision to proceed with a project feasibility study. Project implementation beyond this decision is not in the scope of this publication. Although it is possible to use nuclear energy as a heat source for industrial processes, desalination and other heat applications, it is assumed in this publication that the planning is aimed towards nuclear power for electricity generation. Much of the information given would, however, also be relevant for planning of nuclear reactors for heat production. The publication was prepared within the framework of the IAEA programme on nuclear power planning, implementation and performance as a joint activity of the Nuclear Power Engineering Section and the Planning and Economic Studies Section (Division of Nuclear Power)

  3. Integrated Resource Planning Model (IRPM)

    Energy Technology Data Exchange (ETDEWEB)

    Graham, T. B.

    2010-04-01

    The Integrated Resource Planning Model (IRPM) is a decision-support software product for resource-and-capacity planning. Users can evaluate changing constraints on schedule performance, projected cost, and resource use. IRPM is a unique software tool that can analyze complex business situations from a basic supply chain to an integrated production facility to a distributed manufacturing complex. IRPM can be efficiently configured through a user-friendly graphical interface to rapidly provide charts, graphs, tables, and/or written results to summarize postulated business scenarios. There is not a similar integrated resource planning software package presently available. Many different businesses (from government to large corporations as well as medium-to-small manufacturing concerns) could save thousands of dollars and hundreds of labor hours in resource and schedule planning costs. Those businesses also could avoid millions of dollars of revenue lost from fear of overcommitting or from penalties and lost future business for failing to meet promised delivery by using IRPM to perform what-if business-case evaluations. Tough production planning questions that previously were left unanswered can now be answered with a high degree of certainty. Businesses can anticipate production problems and have solutions in hand to deal with those problems. IRPM allows companies to make better plans, decisions, and investments.

  4. A random approach to the Lebesgue integral

    Science.gov (United States)

    Grahl, Jack

    2008-04-01

    We construct an integral of a measurable real function using randomly chosen Riemann sums and show that it converges in probability to the Lebesgue integral where this exists. We then prove some conditions for the almost sure convergence of this integral.

  5. Integration of design applications with building models

    DEFF Research Database (Denmark)

    Eastman, C. M.; Jeng, T. S.; Chowdbury, R.

    1997-01-01

    This paper reviews various issues in the integration of applications with a building model... (Truncated.)......This paper reviews various issues in the integration of applications with a building model... (Truncated.)...

  6. Contingent approach to Internet-based supply network integration

    Science.gov (United States)

    Ho, Jessica; Boughton, Nick; Kehoe, Dennis; Michaelides, Zenon

    2001-10-01

    The Internet is playing an increasingly important role in enhancing the operations of supply networks as many organizations begin to recognize the benefits of Internet- enabled supply arrangements. However, the developments and applications to-date do not extend significantly beyond the dyadic model, whereas the real advantages are to be made with the external and network models to support a coordinated and collaborative based approach. The DOMAIN research group at the University of Liverpool is currently defining new Internet- enabled approaches to enable greater collaboration across supply chains. Different e-business models and tools are focusing on different applications. Using inappropriate e- business models, tools or techniques will bring negative results instead of benefits to all the tiers in the supply network. Thus there are a number of issues to be considered before addressing Internet based supply network integration, in particular an understanding of supply chain management, the emergent business models and evaluating the effects of deploying e-business to the supply network or a particular tier. It is important to utilize a contingent approach to selecting the right e-business model to meet the specific supply chain requirements. This paper addresses the issues and provides a case study on the indirect materials supply networks.

  7. Integrating incremental learning and episodic memory models of the hippocampal region.

    NARCIS (Netherlands)

    Meeter, M.; Myers, C.E; Gluck, M.A.

    2005-01-01

    By integrating previous computational models of corticohippocampal function, the authors develop and test a unified theory of the neural substrates of familiarity, recollection, and classical conditioning. This approach integrates models from 2 traditions of hippocampal modeling, those of episodic

  8. Hybrid approaches to physiologic modeling and prediction

    Science.gov (United States)

    Olengü, Nicholas O.; Reifman, Jaques

    2005-05-01

    This paper explores how the accuracy of a first-principles physiological model can be enhanced by integrating data-driven, "black-box" models with the original model to form a "hybrid" model system. Both linear (autoregressive) and nonlinear (neural network) data-driven techniques are separately combined with a first-principles model to predict human body core temperature. Rectal core temperature data from nine volunteers, subject to four 30/10-minute cycles of moderate exercise/rest regimen in both CONTROL and HUMID environmental conditions, are used to develop and test the approach. The results show significant improvements in prediction accuracy, with average improvements of up to 30% for prediction horizons of 20 minutes. The models developed from one subject's data are also used in the prediction of another subject's core temperature. Initial results for this approach for a 20-minute horizon show no significant improvement over the first-principles model by itself.

  9. An Integrated Computer-Aided Approach for Environmental Studies

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Chen, Fei; Jaksland, Cecilia

    1997-01-01

    A general framework for an integrated computer-aided approach to solve process design, control, and environmental problems simultaneously is presented. Physicochemical properties and their relationships to the molecular structure play an important role in the proposed integrated approach. The scope...... and applicability of the integrated approach is highlighted through examples involving estimation of properties and environmental pollution prevention. The importance of mixture effects on some environmentally important properties is also demonstrated....

  10. Sparse model selection via integral terms

    Science.gov (United States)

    Schaeffer, Hayden; McCalla, Scott G.

    2017-08-01

    Model selection and parameter estimation are important for the effective integration of experimental data, scientific theory, and precise simulations. In this work, we develop a learning approach for the selection and identification of a dynamical system directly from noisy data. The learning is performed by extracting a small subset of important features from an overdetermined set of possible features using a nonconvex sparse regression model. The sparse regression model is constructed to fit the noisy data to the trajectory of the dynamical system while using the smallest number of active terms. Computational experiments detail the model's stability, robustness to noise, and recovery accuracy. Examples include nonlinear equations, population dynamics, chaotic systems, and fast-slow systems.

  11. An Integrative Model of Internationalization Strategies

    DEFF Research Database (Denmark)

    Li, Xin; Gammelgaard, Jens

    2014-01-01

    Purpose – This paper aims to critically review the ownership, location and internalization (OLI) model and the Uppsala internationalization process (UIP) framework. We suggest that the inclusion of concepts such as corporate entrepreneurship, host country institutions and regulatory focus...... in an integrated framework helps to explain firm internationalization. Design/methodology/approach – This paper is based on a review of the literature on the OLI and UIP models. In addition, it presents a conceptual model that encompasses corporate entrepreneurship, regulatory focus and institutions. Findings...... choice with regard to internationalization. Practical implications – Regulatory focus theory originates from managerial psychology. The model is, therefore, relevant for managers, and it shows how the outcomes and processes of corporate entrepreneurial activity should manifest themselves in managerial...

  12. CANDU plant life management - An integrated approach

    International Nuclear Information System (INIS)

    Charlebois, P.; Hart, R.S.; Hopkins, J.R.

    1998-01-01

    Commercial versions of CANDU reactors were put into service starting more than 25 years ago. The first unit of Ontario Hydro's Pickering A station was put into service in 1971, and Bruce A in 1977. Most CANDU reactors, however, are only now approaching their mid-life of 15 to 20 years of operation. In particular, the first series of CANDU 6 plants which entered service in the early 1980's were designed for a 30 year life and are now approaching mid life. The current CANDU 6 design is based on a 40 year life as a result of advancement in design and materials through research and development. In order to assure safe and economic operation of these reactors, a comprehensive CANDU Plant Life Management (PLIM) program is being developed from the knowledge gained during the operation of Ontario Hydro's Pickering, Bruce, and Darlington stations, worldwide information from CANDU 6 stations, CANDU research and development programs, and other national and international sources. This integration began its first phase in 1994, with the identification of most of the critical systems structures and components in these stations, and a preliminary assessment of degradation and mechanisms that could affect their fitness for service for their planned life. Most of these preliminary assessments are now complete, together with the production of the first iteration of Life Management Plans for several of the systems and components. The Generic CANDU 6 PLIM program is now reaching its maturity, with formal processes to systematically identify and evaluate the major CSSCs in the station, and a plan to ensure that the plant surveillance, operation, and maintenance programs monitor and control component degradation well within the original design specifications essential for the plant life attainment. A Technology Watch program is being established to ensure that degradation mechanisms which could impact on plant life are promptly investigated and mitigating programs established. The

  13. A new approach of Integrated Health Responses (IHR(s)) modeling for ecological risk/health assessments of an urban stream.

    Science.gov (United States)

    Kim, Ja-Hyun; Yeom, Dong-Hyuk; An, Kwang-Guk

    2014-08-01

    The objective of this study was to evaluate the ecological health of an urban stream using Integrated Health Responses (IHRs). Water chemistry analysis, habitat health, and ecotoxicity tests were conducted in the stream along with analyses of molecular/biochemical, physiological biomarkers, and population-level responses in indicator species. Chemical stresses, measured as nutrient levels, ionic content and organic matter concentrations were significantly greater (pmodel (Mm-F) was used to test the community-level response in relation to chemical and physical habitat stresses. The impaired responses of separate biomarker and bioindicator at the downstream sites occurred at all organizations from molecular/biochemical level to community level. Using all biomarkers/bioindicators, the star-plot model of IHRs was developed and then the integrative health/risk assessments were conducted in the urban stream. The reduced values of IHRs occurred in the downstream sites and the impacts were attributed to effluents from wastewater treatment plants (WTPs) and industrial complex. Ecological health impairments, thus, were evident in the urban reach, and reflected the long-term community responses as well as short-term responses of molecular biomarkers. The degradation of the urban stream was mainly due to a combined effect of chemical pollution and physical habitat modifications. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. A design approach for integrating thermoelectric devices using topology optimization

    DEFF Research Database (Denmark)

    Soprani, Stefano; Haertel, Jan Hendrik Klaas; Lazarov, Boyan Stefanov

    2016-01-01

    to operate more efficiently. This work proposes and experimentally demonstrates a topology optimization approach as a design tool for efficient integration of thermoelectric modules into systems with specific design constraints. The approach allows thermal layout optimization of thermoelectric systems....... The design method incorporates temperature dependent properties of the thermoelectric device and other materials. The3D topology optimization model developed in this work was used to design a thermoelectric system, complete with insulation and heat sink, that was produced and tested. Good agreement between...... experimental results and model forecasts was obtained and the system was able to maintain the load at more than 33 K below the oil well temperature. Results of this study support topology optimizationas a powerful design tool for thermal design of thermoelectric systems....

  15. Advanced multiresponse process optimisation an intelligent and integrated approach

    CERN Document Server

    Šibalija, Tatjana V

    2016-01-01

    This book presents an intelligent, integrated, problem-independent method for multiresponse process optimization. In contrast to traditional approaches, the idea of this method is to provide a unique model for the optimization of various processes, without imposition of assumptions relating to the type of process, the type and number of process parameters and responses, or interdependences among them. The presented method for experimental design of processes with multiple correlated responses is composed of three modules: an expert system that selects the experimental plan based on the orthogonal arrays; the factor effects approach, which performs processing of experimental data based on Taguchi’s quality loss function and multivariate statistical methods; and process modeling and optimization based on artificial neural networks and metaheuristic optimization algorithms. The implementation is demonstrated using four case studies relating to high-tech industries and advanced, non-conventional processes.

  16. Development of a model for integrated care at the end of life in advanced dementia: A whole systems UK-wide approach

    Science.gov (United States)

    Jones, Louise; Candy, Bridget; Davis, Sarah; Elliott, Margaret; Gola, Anna; Harrington, Jane; Kupeli, Nuriye; Lord, Kathryn; Moore, Kirsten; Scott, Sharon; Vickerstaff, Victoria; Omar, Rumana Z; King, Michael; Leavey, Gerard; Nazareth, Irwin; Sampson, Elizabeth L

    2015-01-01

    Background: The prevalence of dementia is rising worldwide and many people will die with the disease. Symptoms towards the end of life may be inadequately managed and informal and professional carers poorly supported. There are few evidence-based interventions to improve end-of-life care in advanced dementia. Aim: To develop an integrated, whole systems, evidence-based intervention that is pragmatic and feasible to improve end-of-life care for people with advanced dementia and support those close to them. Design: A realist-based approach in which qualitative and quantitative data assisted the development of statements. These were incorporated into the RAND/UCLA appropriateness method to achieve consensus on intervention components. Components were mapped to underlying theory of whole systems change and the intervention described in a detailed manual. Setting/participants: Data were collected from people with dementia, carers and health and social care professionals in England, from expert opinion and existing literature. Professional stakeholders in all four countries of the United Kingdom contributed to the RAND/UCLA appropriateness method process. Results: A total of 29 statements were agreed and mapped to individual, group, organisational and economic/political levels of healthcare systems. The resulting main intervention components are as follows: (1) influencing local service organisation through facilitation of integrated multi-disciplinary care, (2) providing training and support for formal and informal carers and (3) influencing local healthcare commissioning and priorities of service providers. Conclusion: Use of in-depth data, consensus methods and theoretical understanding of the intervention components produced an evidence-based intervention for further testing in end-of-life care in advanced dementia. PMID:26354388

  17. Impacts of climate change on the food-energy-water nexus in the upper Yellow River Basin: An integrated hydro-economic modeling approach

    Science.gov (United States)

    Si, Y.; Cai, X.

    2017-12-01

    The large-scale reservoir system built on the upper Yellow River serves multiple purposes. The generated hydropower supplies over 60% of the entire electricity for the regional power grid while the irrigated crop production feeds almost one-third of the total population throughout the whole river basin. Moreover, the reservoir system also bears the responsibility for controlling ice flood, which occurs during the non-flood season due to winter ice freezing followed by spring thawing process, and could be even more disastrous than the summer flood. The contradiction of water allocation to satisfy multi-sector demands while mitigating ice flood risk has been longstanding. However, few researchers endeavor to employ the nexus thinking to addressing the complexities involved in all the interlinked purposes. In this study, we develop an integrated hydro-economic model that can be used to explore both the tradeoffs and synergies between the multiple purposes, based on which the water infrastructures (e.g., reservoir, diversion canal, pumping well) can be coordinated for maximizing the co-benefits of multiple sectors. The model is based on a node-link schematic of multiple operations including hydropower generation, irrigation scheduling, and the conjunctive use of surface and ground water resources. In particular, the model depicts some details regarding reservoir operation rules during the ice season using two indicators, i.e., flow control period and flow control level. The rules are obtained from historical records using data mining techniques under different climate conditions, and they are added to the model as part of the system constraints. Future reservoir inflow series are generated by a hydrological model with future climate scenarios projected by General Circulation Model (GCM). By analyzing the model results under the various climate scenarios, the future possible shifting trajectory of the food-energy-water system characteristics will be derived compared to

  18. Integrative and Interdisciplinary Approaches to Leadership Development.

    Science.gov (United States)

    Owen, Julie E

    2015-01-01

    Integrating diverse conceptions of leadership across different disciplines, perspectives, and epistemologies is imperative if leaders are to operate in a global and networked world. Interdisciplinary and integrative leadership courses and digital learning communities are featured examples. © 2015 Wiley Periodicals, Inc., A Wiley Company.

  19. Decomposition approaches to integration without a measure

    Czech Academy of Sciences Publication Activity Database

    Greco, S.; Mesiar, Radko; Rindone, F.; Sipeky, L.

    2016-01-01

    Roč. 287, č. 1 (2016), s. 37-47 ISSN 0165-0114 Institutional support: RVO:67985556 Keywords : Choquet integral * Decision making * Decomposition integral Subject RIV: BA - General Mathematics Impact factor: 2.718, year: 2016 http://library.utia.cas.cz/separaty/2016/E/mesiar-0457408.pdf

  20. An integrated QSAR-PBK/D modelling approach for predicting detoxification and DNA adduct formation of 18 acyclic food-borne α,β-unsaturated aldehydes

    Energy Technology Data Exchange (ETDEWEB)

    Kiwamoto, R., E-mail: reiko.kiwamoto@wur.nl; Spenkelink, A.; Rietjens, I.M.C.M.; Punt, A.

    2015-01-01

    Acyclic α,β-unsaturated aldehydes present in food raise a concern because the α,β-unsaturated aldehyde moiety is considered a structural alert for genotoxicity. However, controversy remains on whether in vivo at realistic dietary exposure DNA adduct formation is significant. The aim of the present study was to develop physiologically based kinetic/dynamic (PBK/D) models to examine dose-dependent detoxification and DNA adduct formation of a group of 18 food-borne acyclic α,β-unsaturated aldehydes without 2- or 3-alkylation, and with no more than one conjugated double bond. Parameters for the PBK/D models were obtained using quantitative structure–activity relationships (QSARs) defined with a training set of six selected aldehydes. Using the QSARs, PBK/D models for the other 12 aldehydes were defined. Results revealed that DNA adduct formation in the liver increases with decreasing bulkiness of the molecule especially due to less efficient detoxification. 2-Propenal (acrolein) was identified to induce the highest DNA adduct levels. At realistic dietary intake, the predicted DNA adduct levels for all aldehydes were two orders of magnitude lower than endogenous background levels observed in disease free human liver, suggesting that for all 18 aldehydes DNA adduct formation is negligible at the relevant levels of dietary intake. The present study provides a proof of principle for the use of QSAR-based PBK/D modelling to facilitate group evaluations and read-across in risk assessment. - Highlights: • Physiologically based in silico models were made for 18 α,β-unsaturated aldehydes. • Kinetic parameters were determined by in vitro incubations and a QSAR approach. • DNA adduct formation was negligible at levels relevant for dietary intake. • The use of QSAR-based PBK/D modelling facilitates group evaluations and read-across.

  1. Econometric analysis of the R and D performance in the national hydrogen energy technology development for measuring relative efficiency: The fuzzy AHP/DEA integrated model approach

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seong Kon; Kim, Jong Wook [Energy Policy Research Center, Korea Institute of Energy Research, 71-2, Jang-dong, Yuseong-gu, Daejeon 305-343 (Korea); Mogi, Gento [Department of Technology management for innovation, Graduate School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Lee, Sang Kon [PNU-IFAM Joint Research Center, Pusan National University, 30 Jangjeon-Dong, Kumjeong-Gu, Busan 609-735 (Korea); Hui, K.S. [Department of Manufacturing Engineering and Engineering Management, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong (China)

    2010-03-15

    Hydrogen energy technology can be one of the best key players related to the sector of the United Nations Framework Convention on Climate Change (UNFCCC) and the hydrogen economy. Comparing to other technologies, hydrogen energy technology is more environmentally sound and friendly energy technology and has great potential as a future dominant energy carrier. Advanced nations including Korea have been focusing on the development of hydrogen energy technology R and D for the sustainable development and low carbon green society. In this paper, we applied the integrated fuzzy analytic hierarchy process (Fuzzy AHP) and the data envelopment analysis (DEA) for measuring the relative efficiency of the R and D performance in the national hydrogen energy technology development. On the first stage, the fuzzy AHP effectively reflects the vagueness of human thought. On the second stage, the DEA approach measures the relative efficiency of the national R and D performance in the sector of hydrogen energy technology development with economic viewpoints. The efficiency score can be the fundamental data for policymakers for the well focused R and D planning. (author)

  2. Integrating lifestyle approaches into osteoarthritis care

    Directory of Open Access Journals (Sweden)

    Garver MJ

    2015-09-01

    Full Text Available Matthew J Garver,1 Brian C Focht,2 Sarah J Taylor3 1Department of Kinesiology and Nutrition, Abilene Christian University, Abilene, TX, 2Department of Human Sciences, Ohio State University, Columbus, OH, 3School of Occupational Therapy, Texas Woman's University, Dallas, TX, USA Abstract: As the lifetime risk, societal cost, and overall functional impact of osteoarthritis (OA is imposing, it is imperative that clinicians provide an individualized care model for patients. Patients must be offered a multiplicity of care strategies and encouraged to embrace lifestyle approaches for self-managing the effects and symptoms of OA. Certainly, the attitude of the clinician and patient will directly influence receptivity and implementation of lifestyle approaches. This work proposes how the use of structured and routine assessments and cognitive therapy ideologies may complement a comprehensive treatment plan. Assessments described herein include objective and/or self-report measures of physical function, pain, attitude about social support, and sleep quality. Baseline assessments followed by systematic monitoring of the results may give patients and clinicians valuable insight into the effectiveness of the care plan. Empirical evidence from randomized trials with OA patients highlights the effectiveness of cognitive behavioral change strategies for addressing salient concerns for OA (pain control, mobility performance, and sleep quality. Cognitive restructuring can provide patients with renewed power in managing their disease. Cognitive therapy topics discussed presently include: 1 what is OA?, 2 effectiveness of exercise and FITT (frequency, intensity, time, and type principles for OA patients, 3 goal-setting and barriers, and 4 translating to independent care. Woven within the discussion about cognitive therapy are ideas about how the results from baseline assessments and group-mediated dynamics might assist more favorable outcomes. There are a plethora

  3. Integrated landscape-based approach of remote sensing, GIS, and physical modelling to study the hydrological connectivity of wetlands to the downstream water: progress and challenge

    Science.gov (United States)

    Yeo, I. Y.

    2015-12-01

    We report the recent progress on our effort to improve the mapping of wetland dynamics and the modelling of its functioning and hydrological connection to the downstream waters. Our study focused on the Coastal Plain of the Chesapeake Bay Watershed (CBW), the Delmarva Peninsula, where the most of wetlands in CBW are densely distributed. The wetland ecosystem plays crucial roles in improving water quality and ecological integrity for the downstream waters and the Chesapeake Bay, and headwater wetlands in the region, such as Delmarva Bay, are now subject to the legal protection under the Clean Water Rules. We developed new wetland maps using time series Landsat images and a highly accurate LiDAR map over last 30 years. These maps show the changes in surface water fraction at a 30-m grid cell at annual time scale. Using GIS, we analyse these maps to characterize changing dynamics of wetland inundation due to the physical environmental factors (e.g., weather variability, tide) and assessed the hydrological connection of wetlands to the downstream water at the watershed scale. Focusing on the two adjacent watersheds in the upper region of the Choptank River Basin, we study how wetland inundation dynamics and the hydrologic linkage of wetlands to downstream water would vary by the local hydrogeological setting and attempt to identify the key landscape factors affecting the wetland ecosystems and functioning. We then discuss the potential of using remote sensing products to improve the physical modelling of wetlands from our experience with SWAT (Soil and Water Assessment Tool).

  4. An integrated approach to change leadership.

    Science.gov (United States)

    Skelton-Green, Judith; Simpson, Beverley; Scott, Julia

    2007-01-01

    Leading change has become one of the essential core competencies of health professionals today. Since 2001, the authors have been the key designers and facilitators of the Dorothy Wylie Nursing Leadership Institute (DMW-NLI). The background, key characteristics and benefits of the DMW-NLI have been described in detail elsewhere (Simpson et al. 2002). One of the Institute's key features is that participants bring a change initiative that they wish to pursue and - during their time on site - we assist them in developing that project to the point where it has a strong chance of success. When we incorporated this aspect into the DMW-NLI program, we believed that opportunity to apply the learning of the Institute to a desired initiative in the home setting would add significant value, not only to the participants, but also to their sponsoring organizations. Further, it was our hope that we could develop a methodology to advance the change initiative, which would be a valuable tool that participants could use in future change projects.As we looked to the literature, we found no shortage of articles on change theory, as well as numerous tools and techniques for project management. However, we did not find one single approach or methodology that we felt was comprehensive yet concise enough to serve as a practical guide for those who wish to advance a change initiative in their practice settings today. Therefore, we developed an integrated conceptual framework and methodology for leading change initiatives, building on selected current and classic theories of change that are relevant today. Both the framework and methodology have proven very hardy, and will, we believe, be of interest to nurse leaders and other health professionals in leadership roles. This paper will provide a brief overview of relevant background literature on leading change initiatives, introduce the DMW-NLI Change Leadership conceptual framework, describe a number of activities that support the

  5. Data Integration The Relational Logic Approach

    CERN Document Server

    Genesereth, Michael

    2010-01-01

    Data integration is a critical problem in our increasingly interconnected but inevitably heterogeneous world. There are numerous data sources available in organizational databases and on public information systems like the World Wide Web. Not surprisingly, the sources often use different vocabularies and different data structures, being created, as they are, by different people, at different times, for different purposes. The goal of data integration is to provide programmatic and human users with integrated access to multiple, heterogeneous data sources, giving each user the illusion of a sin

  6. An integrated approach to determine phenomenological equations in metallic systems

    Science.gov (United States)

    Ghamarian, Iman

    It is highly desirable to be able to make predictions of properties in metallic materials based upon the composition of the material and the microstructure. Unfortunately, the complexity of real, multi-component, multi-phase engineering alloys makes the provision of constituent-based (i.e., composition or microstructure) phenomenological equations extremely difficult. Due to these difficulties, qualitative predictions are frequently used to study the influence of microstructure or composition on the properties. Neural networks were used as a tool to get a quantitative model from a database. However, the developed model is not a phenomenological model. In this study, a new method based upon the integration of three separate modeling approaches, specifically artificial neural networks, genetic algorithms, and monte carlo was proposed. These three methods, when coupled in the manner described in this study, allows for the extraction of phenomenological equations with a concurrent analysis of uncertainty. This approach has been applied to a multi-component, multi-phase microstructure exhibiting phases with varying spatial and morphological distributions. Specifically, this approach has been applied to derive a phenomenological equation for the prediction of yield strength in alpha+beta processed Ti-6-4. The equation is consistent with not only the current dataset but also, where available, the limited information regarding certain parameters such as intrinsic yield strength of pure hexagonal close-packed alpha titanium.

  7. An integrated Boltzmann+hydrodynamics approach to heavy ion collisions

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, Hannah

    2009-04-22

    In this thesis the first fully integrated Boltzmann+hydrodynamics approach to relativistic heavy ion reactions has been developed. After a short introduction that motivates the study of heavy ion reactions as the tool to get insights about the QCD phase diagram, the most important theoretical approaches to describe the system are reviewed. The hadron-string transport approach that this work is based on is the Ultra-relativistic Quantum Molecular Dynamics (UrQMD) approach. Predictions for the charged particle multiplicities at LHC energies are made. The next step is the development of a new framework to calculate the baryon number density in a transport approach. Time evolutions of the net baryon number and the quark density have been calculated at AGS, SPS and RHIC energies. Studies of phase diagram trajectories using hydrodynamics are performed. The hybrid approach that has been developed as the main part of this thesis is based on the UrQMD transport approach with an intermediate hydrodynamical evolution for the hot and dense stage of the collision. The full (3+1) dimensional ideal relativistic one fluid dynamics evolution is solved using the SHASTA algorithm. Three different equations of state have been used, namely a hadron gas equation of state without a QGP phase transition, a chiral EoS and a bag model EoS including a strong first order phase transition. For the freeze-out transition from hydrodynamics to the cascade calculation two different set-ups are employed. The parameter dependences of the model are investigated and the time evolution of different quantities is explored. The hybrid model calculation is able to reproduce the experimentally measured integrated as well as transverse momentum dependent v{sub 2} values for charged particles. The multiplicity and mean transverse mass excitation function is calculated for pions, protons and kaons in the energy range from E{sub lab}=2-160 A GeV. The HBT correlation of the negatively charged pion source

  8. The Impact of Technology Integration through a Transformative Approach

    Science.gov (United States)

    Cubillos, Jo Ann

    2013-01-01

    The integration of technology into classroom instruction in K-12 schools remains problematic. The problems associated with this integration are troubling, as technology integration may change a teacher's pedagogy toward more innovative approaches that increase student achievement. The purpose of this study was to document teachers' experiences as…

  9. Model integration and the economics of nuclear power

    International Nuclear Information System (INIS)

    Lundgren, S.

    1985-01-01

    The author proposes and applies a specific approach to model integration, i.e. the merger of two or several independently developed models. The approach is intended for integrations of activity analysis sector models and applied general equilibrium models. Model integration makes it possible to extend the range of applicability of applied general equilibrium models by exploiting the information contained in sector models. It also makes it possible to evaluate the validity of the partial equilibrium analyses in which sector models often are employed. The proposed approach is used to integrate a sector model of electricity and heat production with a general equilibrium model of the Swedish economy. Both models have been constructed within the research programme. The author uses the integrated model to look at two issues concerning the role of nuclear power on the Swedish electricity market: What are the likely consequences of a nuclear power discontinuation and how does the nuclear power investment programme of the 1970's and the early 1980's compare with a socially efficient one. (Author)

  10. HeartMath and Ubuntu integral healing approaches for social ...

    African Journals Online (AJOL)

    HeartMath and Ubuntu integral healing approaches for social coherence and physical activity. Stephen D. Edwards. Abstract. This research was motivated by many social health problems confronting planet earth. Its aim is to introduce HeartMath and Ubuntu as complimentary, integral healing approaches for promoting ...

  11. World Integrated Nuclear Evaluation System: Model documentation

    International Nuclear Information System (INIS)

    1991-12-01

    The World Integrated Nuclear Evaluation System (WINES) is an aggregate demand-based partial equilibrium model used by the Energy Information Administration (EIA) to project long-term domestic and international nuclear energy requirements. WINES follows a top-down approach in which economic growth rates, delivered energy demand growth rates, and electricity demand are projected successively to ultimately forecast total nuclear generation and nuclear capacity. WINES could be potentially used to produce forecasts for any country or region in the world. Presently, WINES is being used to generate long-term forecasts for the United States, and for all countries with commercial nuclear programs in the world, excluding countries located in centrally planned economic areas. Projections for the United States are developed for the period from 2010 through 2030, and for other countries for the period starting in 2000 or 2005 (depending on the country) through 2010. EIA uses a pipeline approach to project nuclear capacity for the period between 1990 and the starting year for which the WINES model is used. This approach involves a detailed accounting of existing nuclear generating units and units under construction, their capacities, their actual or estimated time of completion, and the estimated date of retirements. Further detail on this approach can be found in Appendix B of Commercial Nuclear Power 1991: Prospects for the United States and the World

  12. Integrated hydrological model-based assessment of stormwater management scenarios in Copenhagen's first climate resilient neighbourhood using the three point approach

    DEFF Research Database (Denmark)

    Lerer, Sara Maria; Righetti, Francesco; Rozario, Thomas

    2017-01-01

    The city of Copenhagen currently pursues a very ambitious plan to make the city 'cloudburst proof' within the next 30 years. The cloudburst management plan has the potential to support the city's aim to become more green, liveable, and sustainable. In this study, we assessed stormwater system...... designs using the Three Point Approach (3PA) as a framework, where an indicator value for each domain was calculated using state-of-the-art modelling techniques. We demonstrated the methodology on scenarios representing sequential enhancements of the cloudburst management plan for a district that has been...... appointed to become the first climate resilient neighbourhood in Copenhagen. The results show that if the cloudburst system is exploited to discharge runoff from selected areas that are disconnected from the combined sewer system, then the plan leads to multiple benefits. These include improved flood...

  13. Wilber's Integral Theory and Dossey's Theory of Integral Nursing: An Examination of Two Integral Approaches in Nursing Scholarship.

    Science.gov (United States)

    Shea, Linda; Frisch, Noreen

    2016-09-01

    The purpose of this article is to examine Dossey's theory of integral nursing in relation to its major theoretical source, Wilber's integral theory. Although several nursing scholars have written about integral theory in relation to nursing scholarship and practice, Dossey's theory of integral nursing may be influencing how nurses take up integral theory in a significant way due to an extensive outreach in the holistic nursing community. Despite this wide circulation, the theory of integral nursing has yet to be reviewed in the nursing literature. This article (a) compares Dossey's theory of integral nursing with Wilber's integral theory and (b) contrasts Dossey's integral approach with another integral approach used by other scholars of integral theory. © The Author(s) 2015.

  14. Evaluation of 5536 patients treated in an integrative outpatient tinnitus treatment center-immediate effects and a modeling approach for sustainability.

    Science.gov (United States)

    Ostermann, Thomas; Boehm, Katja; Kusatz, Martin

    2016-08-11

    Tinnitus is an increasingly serious problem for health care systems. According to epidemiological data, 7-14 % of outpatients have asked their physician about tinnitus and management strategies. Integrative outpatient treatments are currently regarded as promising therapeutic approaches for managing tinnitus. In this article we report on the treatment success of an outpatient tinnitus treatment center in Germany. This cohort study included pre-post data of 5536 outpatients which were treated between 2003 and 2010 in the tinnitus-therapy center, Krefeld-Düsseldorf (TTZ). The intervention consisted of psychological immunization training as well as an auditory stimulation therapy component. The main outcome parameter was the score of the Tinnitus Questionnaire (TQ) which was assessed before and after a 9 days treatment and (in a small subsample) at a 6 months follow-up. Missing data were multiply imputed. Pre-post effect sizes were calculated and adjusted for regression to the mean (RTM). RTM-adjusted treatment effects at the end of treatment were estimated as -18.6 (CI: -18.9 to 18.2, p < 0.001) score points which corresponds to a standardized effect of d = -1.03 (CI: -1.05 to -1.01). These effects can be corroborated in various subgroups and all subscales of the TQ (d ranging from -0.31 to -0.97). The study suggests the effectiveness of this outpatient tinnitus therapy concept. Multiple imputations techniques and RTM analysis were helpful in carving out true treatment effects.

  15. An integrated approach to modeling changes in land use, land cover, and disturbance and their impact on ecosystem carbon dynamics: a case study in the Sierra Nevada Mountains of California

    Science.gov (United States)

    Sleeter, Benjamin M.; Liu, Jinxun; Daniel, Colin; Frid, Leonardo; Zhu, Zhiliang

    2015-01-01

    Increased land-use intensity (e.g. clearing of forests for cultivation, urbanization), often results in the loss of ecosystem carbon storage, while changes in productivity resulting from climate change may either help offset or exacerbate losses. However, there are large uncertainties in how land and climate systems will evolve and interact to shape future ecosystem carbon dynamics. To address this we developed the Land Use and Carbon Scenario Simulator (LUCAS) to track changes in land use, land cover, land management, and disturbance, and their impact on ecosystem carbon storage and flux within a scenario-based framework. We have combined a state-and-transition simulation model (STSM) of land change with a stock and flow model of carbon dynamics. Land-change projections downscaled from the Intergovernmental Panel on Climate Change’s (IPCC) Special Report on Emission Scenarios (SRES) were used to drive changes within the STSM, while the Integrated Biosphere Simulator (IBIS) ecosystem model was used to derive input parameters for the carbon stock and flow model. The model was applied to the Sierra Nevada Mountains ecoregion in California, USA, a region prone to large wildfires and a forestry sector projected to intensify over the next century. Three scenario simulations were conducted, including a calibration scenario, a climate-change scenario, and an integrated climate- and land-change scenario. Based on results from the calibration scenario, the LUCAS age-structured carbon accounting model was able to accurately reproduce results obtained from the process-based biogeochemical model. Under the climate-only scenario, the ecoregion was projected to be a reliable net sink of carbon, however, when land use and disturbance were introduced, the ecoregion switched to become a net source. This research demonstrates how an integrated approach to carbon accounting can be used to evaluate various drivers of ecosystem carbon change in a robust, yet transparent modeling

  16. An integrated approach to modeling changes in land use, land cover, and disturbance and their impact on ecosystem carbon dynamics: a case study in the Sierra Nevada Mountains of California

    Directory of Open Access Journals (Sweden)

    Benjamin M. Sleeter

    2015-06-01

    Full Text Available Increased land-use intensity (e.g. clearing of forests for cultivation, urbanization, often results in the loss of ecosystem carbon storage, while changes in productivity resulting from climate change may either help offset or exacerbate losses. However, there are large uncertainties in how land and climate systems will evolve and interact to shape future ecosystem carbon dynamics. To address this we developed the Land Use and Carbon Scenario Simulator (LUCAS to track changes in land use, land cover, land management, and disturbance, and their impact on ecosystem carbon storage and flux within a scenario-based framework. We have combined a state-and-transition simulation model (STSM of land change with a stock and flow model of carbon dynamics. Land-change projections downscaled from the Intergovernmental Panel on Climate Change’s (IPCC Special Report on Emission Scenarios (SRES were used to drive changes within the STSM, while the Integrated Biosphere Simulator (IBIS ecosystem model was used to derive input parameters for the carbon stock and flow model. The model was applied to the Sierra Nevada Mountains ecoregion in California, USA, a region prone to large wildfires and a forestry sector projected to intensify over the next century. Three scenario simulations were conducted, including a calibration scenario, a climate-change scenario, and an integrated climate- and land-change scenario. Based on results from the calibration scenario, the LUCAS age-structured carbon accounting model was able to accurately reproduce results obtained from the process-based biogeochemical model. Under the climate-only scenario, the ecoregion was projected to be a reliable net sink of carbon, however, when land use and disturbance were introduced, the ecoregion switched to become a net source. This research demonstrates how an integrated approach to carbon accounting can be used to evaluate various drivers of ecosystem carbon change in a robust, yet transparent

  17. Forecasting labour supply and population: An integrated stochastic model

    OpenAIRE

    Fuchs, Johann; Söhnlein, Doris; Weber, Brigitte; Weber, Enzo

    2017-01-01

    This paper presents a stochastic integrated model to forecast the German population and labour supply until 2060. Within a cohort-component approach, the population forecast applies principal components to birth, mortality, emigration and immigration rates. The labour force participation rates are estimated by means of an econometric time series approach. All time series are forecast by bootstrapping. This allows fully integrated simulations and the possibility to illustrate the uncertainties...

  18. The meaning of integrated care: a systems approach

    Directory of Open Access Journals (Sweden)

    Lars Edgren

    2008-10-01

    Full Text Available Introduction: Organizations can be regarded as systems. The traditional model of systems views them as machines. This seems to be insufficient when it comes to understanding and organizing complex tasks. To better understand integrated care we should approach organizations as constantly changing living organisms, where many agents are interconnected in so-called Complex Adaptive Systems (CAS. Theory and discussion: The term “complex” emphasizes that the necessary competence to perform a task is not owned by any one part, but comes as a result of co-operation within the system. “Adaptive” means that system change occurs through successive adaptations. A CAS consists of several subsystems called agents, which act in dependence of one another. Examples would be the ant-hill, the human immune defence, the financial market and the surgical operating theatre team. Studying a CAS, the focus is on the interaction and communication between agents. Although these thoughts are not new, the CAS-approach has not yet been widely applied to the management of integrated care. This helps the management to understand why the traditional top down way of managing, following the machine model thinking, may meet with problems in interdependent organizations with complex tasks. Conclusion: When we perceive health and social services as CASs we should gain more insight into the processes that go on within and between organizations and how top management, for example within a hospital, in fact executes its steering function.

  19. Integrating software into PRA: a test-based approach.

    Science.gov (United States)

    Li, Bin; Li, Ming; Smidts, Carol

    2005-08-01

    Probabilistic risk assessment (PRA) is a methodology to assess the probability of failure or success of a system's operation. PRA has been proved to be a systematic, logical, and comprehensive technique for risk assessment. Software plays an increasing role in modern safety critical systems. A significant number of failures can be attributed to software failures. Unfortunately, current probabilistic risk assessment concentrates on representing the behavior of hardware systems, humans, and their contributions (to a limited extent) to risk but neglects the contributions of software due to a lack of understanding of software failure phenomena. It is thus imperative to consider and model the impact of software to reflect the risk in current and future systems. The objective of our research is to develop a methodology to account for the impact of software on system failure that can be used in the classical PRA analysis process. A test-based approach for integrating software into PRA is discussed in this article. This approach includes identification of software functions to be modeled in the PRA, modeling of the software contributions in the ESD, and fault tree. The approach also introduces the concepts of input tree and output tree and proposes a quantification strategy that uses a software safety testing technique. The method is applied to an example system, PACS.

  20. Investigation of Integrated Vehicle Health Management Approaches

    Science.gov (United States)

    Paris, Deidre

    2005-01-01

    This report is to present the work that was performed during the summer in the Advance Computing Application office. The NFFP (NASA Faculty Fellow Program) had ten summer faculty members working on IVHM (Integrated Vehicle Health Management) technologies. The objective of this project was two-fold: 1) to become familiar with IVHM concepts and key demonstrated IVHM technologies; and 2) to integrate the research that has been performed by IVHM faculty members into the MASTLAB (Marshall Avionic Software Test Lab). IVHM is a NASA-wide effort to coordinate, integrate and apply advanced software, sensors and design technologies to increase the level of intelligence, autonomy, and health state of future vehicles. IVHM is an important concept because it is consistent with the current plan for NASA to go to the moon, mars, and beyond. In order for NASA to become more involved in deep exploration, avionic systems will need to be highly adaptable and autonomous.

  1. Approaches to Integrated Building Design Environments

    DEFF Research Database (Denmark)

    Bagger-Petersen, Susanne C; Andersen, Tom

    1996-01-01

    This report discusses functional requirements and specification which needs to be defined and fulfilled to initiate development of an integrated building design environment. The purpose is to outline specifications for further discussion and development. The report documents the first phase...... in an ongoing project at the Technical University of Denmark. The overall project objective is to provide a theoretically well-founded prototype of an integrated IT-system which can serve as a device of feedback from practice and as a test-bed for the developed concept and architecture....

  2. Field theory a path integral approach

    CERN Document Server

    Das, Ashok

    2006-01-01

    This unique book describes quantum field theory completely within the context of path integrals. With its utility in a variety of fields in physics, the subject matter is primarily developed within the context of quantum mechanics before going into specialized areas.Adding new material keenly requested by readers, this second edition is an important expansion of the popular first edition. Two extra chapters cover path integral quantization of gauge theories and anomalies, and a new section extends the supersymmetry chapter, where singular potentials in supersymmetric systems are described.

  3. Integrated multi-scale modelling and simulation of nuclear fuels

    International Nuclear Information System (INIS)

    Valot, C.; Bertolus, M.; Masson, R.; Malerba, L.; Rachid, J.; Besmann, T.; Phillpot, S.; Stan, M.

    2015-01-01

    This chapter aims at discussing the objectives, implementation and integration of multi-scale modelling approaches applied to nuclear fuel materials. We will first show why the multi-scale modelling approach is required, due to the nature of the materials and by the phenomena involved under irradiation. We will then present the multiple facets of multi-scale modelling approach, while giving some recommendations with regard to its application. We will also show that multi-scale modelling must be coupled with appropriate multi-scale experiments and characterisation. Finally, we will demonstrate how multi-scale modelling can contribute to solving technology issues. (authors)

  4. The Integration Movement in the Caribbean at Crossroads: Towards a New Approach of Integration

    OpenAIRE

    Uziel Nogueira

    1997-01-01

    The Institute for the Integration of Latin America and the Caribbean (INTAL) has inaugurated a Working Papers Series with the publication of a study by Uziel Nogueira, the Institute's Economist. Entitled "The Integration Movement in the Caribbean at the Crossroads: Towards a New Approach to Integration", the study opens with an overview of the movement towards integration among the English-speaking countries of the Caribbean. It continues with an analysis of the integration process during thi...

  5. Integrating Emotion-Focused Therapy with the Satir Model

    Science.gov (United States)

    Brubacher, Lorrie

    2006-01-01

    The experiential humanistic family systems approach of Virginia Satir lacks a theoretical structure and is thus vulnerable to losing its experiential nature and being reduced to a mere collection of creative techniques. A way to effectively keep Satir's transformative presence alive is to integrate her approach with a model that is solidly…

  6. An integrated systems engineering approach to aircraft design

    Science.gov (United States)

    Price, M.; Raghunathan, S.; Curran, R.

    2006-06-01

    The challenge in Aerospace Engineering, in the next two decades as set by Vision 2020, is to meet the targets of reduction of nitric oxide emission by 80%, carbon monoxide and carbon dioxide both by 50%, reduce noise by 50% and of course with reduced cost and improved safety. All this must be achieved with expected increase in capacity and demand. Such a challenge has to be in a background where the understanding of physics of flight has changed very little over the years and where industrial growth is driven primarily by cost rather than new technology. The way forward to meet the challenges is to introduce innovative technologies and develop an integrated, effective and efficient process for the life cycle design of aircraft, known as systems engineering (SE). SE is a holistic approach to a product that comprises several components. Customer specifications, conceptual design, risk analysis, functional analysis and architecture, physical architecture, design analysis and synthesis, and trade studies and optimisation, manufacturing, testing validation and verification, delivery, life cycle cost and management. Further, it involves interaction between traditional disciplines such as Aerodynamics, Structures and Flight Mechanics with people- and process-oriented disciplines such as Management, Manufacturing, and Technology Transfer. SE has become the state-of-the-art methodology for organising and managing aerospace production. However, like many well founded methodologies, it is more difficult to embody the core principles into formalised models and tools. The key contribution of the paper will be to review this formalisation and to present the very latest knowledge and technology that facilitates SE theory. Typically, research into SE provides a deeper understanding of the core principles and interactions, and helps one to appreciate the required technical architecture for fully exploiting it as a process, rather than a series of events. There are major issues as

  7. An Integrated Approach to Teaching Agriculture.

    Science.gov (United States)

    Jenkinson, G. M.; And Others

    1989-01-01

    Outlines developments that took place in teaching agriculture at the freshman-sophomore level and the concept of integrated courses in agriculture. Future directions include: more emphasis on the impact of technology, case-study forms, and efforts to shift the balance from content to concept. (Author/RT)

  8. A Symmetric Approach Elucidates Multisensory Information Integration

    Directory of Open Access Journals (Sweden)

    Arturo Tozzi

    2016-12-01

    Full Text Available Recent advances in neuronal multisensory integration suggest that the five senses do not exist in isolation of each other. Perception, cognition and action are integrated at very early levels of central processing, in a densely-coupled system equipped with multisensory interactions occurring at all temporal and spatial stages. In such a novel framework, a concept from the far-flung branch of topology, namely the Borsuk-Ulam theorem, comes into play. The theorem states that when two opposite points on a sphere are projected onto a circumference, they give rise to a single point containing their matching description. Here we show that the theorem applies also to multisensory integration: two environmental stimuli from different sensory modalities display similar features when mapped into cortical neurons. Topological tools not only shed new light on questions concerning the functional architecture of mind and the nature of mental states, but also provide an empirically assessable methodology. We argue that the Borsuk-Ulam theorem is a general principle underlying nervous multisensory integration, resulting in a framework that has the potential to be operationalized.

  9. Integrated approach to economical, reliable, safe nuclear power production

    International Nuclear Information System (INIS)

    1982-06-01

    An Integrated Approach to Economical, Reliable, Safe Nuclear Power Production is the latest evolution of a concept which originated with the Defense-in-Depth philosophy of the nuclear industry. As Defense-in-Depth provided a framework for viewing physical barriers and equipment redundancy, the Integrated Approach gives a framework for viewing nuclear power production in terms of functions and institutions. In the Integrated Approach, four plant Goals are defined (Normal Operation, Core and Plant Protection, Containment Integrity and Emergency Preparedness) with the attendant Functional and Institutional Classifications that support them. The Integrated Approach provides a systematic perspective that combines the economic objective of reliable power production with the safety objective of consistent, controlled plant operation

  10. Advanced Manufacturing Technologies (AMT): Composites Integrated Modeling

    Data.gov (United States)

    National Aeronautics and Space Administration — The Composites Integrated Modeling (CIM) Element developed low cost, lightweight, and efficient composite structures, materials and manufacturing technologies with...

  11. Evaluation of a combined approach of clinical skills training utilizing near-peers, in-campus faculty and clinicians: An innovative integrated model.

    Science.gov (United States)

    Zafar, Muhammad; Inayah, A'man Talal; Shareef, Mohammad Abrar; Aldalati, Alaa M Z; Afsar, Nasir Ali; Abu-Zaid, Ahmed; Zafar, Fatimah; Azouz, Haya Jamal

    2016-01-01

    Training clinical skills is essential in medicine. Different models of clinical skills courses have been previously suggested. Here, we report an innovative approach adopted to train junior medical students in clinical skills in a multimodal fashion by near-peers, basic scientists with clinical background and senior clinicians. This quasi-experimental study was conducted at Alfaisal University College of Medicine at Riyadh. An electronic survey was conducted among year-2 and year-3 medical students seeking their perception about the (a) organization, (b) delivery, (c&d) self- and peer-assessment in clinical skills courses. Total 298 male and female medical students (91%), consisting of 164 from year 2 and 134 from year 3, participated by filling out a questionnaire (Cronbach's alpha 0.93). Out of maximum five, the average ratings for the course were 3.81, 3.72, 3.67 and 3.73 in organization, delivery, self-evaluation and peer-assessment respectively, with no significant difference between both subgroups. The in-campus sessions rated higher than hospital sessions (p < 0.001). As tutors, interns were rated higher than clinicians (p < 0.001). The qualitative analysis suggested high satisfaction. The clinical skills course that was conducted in a multimodal fashion utilizing diverse tutors showed a positive attitude of students toward the organization and delivery of the course.

  12. Integrated Hydrological Model-Based Assessment of Stormwater Management Scenarios in Copenhagen’s First Climate Resilient Neighbourhood Using the Three Point Approach

    Directory of Open Access Journals (Sweden)

    Sara Maria Lerer

    2017-11-01

    Full Text Available The city of Copenhagen currently pursues a very ambitious plan to make the city ‘cloudburst proof’ within the next 30 years. The cloudburst management plan has the potential to support the city’s aim to become more green, liveable, and sustainable. In this study, we assessed stormwater system designs using the Three Point Approach (3PA as a framework, where an indicator value for each domain was calculated using state-of-the-art modelling techniques. We demonstrated the methodology on scenarios representing sequential enhancements of the cloudburst management plan for a district that has been appointed to become the first climate resilient neighbourhood in Copenhagen. The results show that if the cloudburst system is exploited to discharge runoff from selected areas that are disconnected from the combined sewer system, then the plan leads to multiple benefits. These include improved flood protection under a 100-years storm (i.e., compliance with the new demands in domain C of the 3PA, reduced surcharge to terrain under a 10-years storm (i.e., compliance with the service goal in domain B of the 3PA and an improved yearly water balance (i.e., better performance in domain A of the 3PA.

  13. Integrating biopharmaceutics risk assessment and in vivo absorption model in formulation development of BCS class I drug using the QbD approach.

    Science.gov (United States)

    Charoo, Naseem A; Cristofoletti, Rodrigo; Kim, Sun K

    2017-04-01

    Clinically relevant critical quality attributes (CQA's) were identified for the development of generic drug products containing fluconazole and potential design spaces relevant to the clinical application of the drug candidate was explored. A simplified scoring system for the biopharmaceutics risk assessment roadmap (BioRAM) is proposed to guide product development. Factorial design of experiments was employed to study the effect of formulation and process variables on CQA's. The in vivo model was developed for predicting the fraction of drug absorbed and to identify the effect of formulation components on drug absorption. BioRAM yielded low scores for fluconazole absorption with respect to severity (risks of sub and supra-bioavailable drug products), probability of incidence of bioinequivalent results and capacity of detection. The results demonstrated that dissolution was highly influenced by the active pharmaceutical ingredient (API) polymorphism and the ratio of diluents. Process variables (mixing time, lubricant concentration, lubrication time and filling speed) did not impact the clinical outcome of the formulation with respect to dissolution and content uniformity. Understanding the clinical implications of the adopted formulation approach led to the construction of purposeful design space and control strategy.

  14. Ramjets: Thermal Management an Integrated Engineering Approach

    Science.gov (United States)

    2010-09-01

    and Thermal Management (Propulsion a vitesse elevee : Conception du moteur - integration et gestion thermique ) 14. ABSTRACT Within the framework of...2.0 AERODYNAMIC HEATING 2.1 General Heat Transfer Relations The air flow around any vehicle moving through the atmosphere comes to rest at the...resulting in a convective heat flux from the air flow to the structure of the vehicle. The basic equation describing convective heat transfer is: )( wawcc

  15. The line integral approach to radarclinometry

    Science.gov (United States)

    Wildey, R.L.

    1987-01-01

    Radarclinometry, the invention of which has been previously reported, is a technique for deriving a topographic map from a single radar image by using the dependence upon terrain-surface orientation of the integrated signal of an individual image pixel. The radiometric calibration required for precise operation and testing does not yet exist, but the imminence of important applications justifies parallel, rather than serial, development of radarclinometry and radiometrically calibrated radar. The present investigation reports three developmental advances: (1) The solid angle of integration of back-scattered specific intensity constituting a pixel signal is more accurately accounted for in its dependence on surface orientation than in previous work. (2) The local curvature hypothesis, which removes the requirement of a ground-truth profile as a boundary condition and enables the formulation of the theory in terms of a line integral, has been expanded to include the three possibilities of Local Cylindricity, Local Biaxial Ellipsoidal Hyperbolicity, and Least-Squares Local Sphericity. (3) The theory is integrated in the cross-ground-range direction, which is ill-conditioned compared to the ground-range direction, whereas the original formulation was based on enforced isotropy in the two-dimensional power spectrum of the topography. It was found necessary to prohibit the hypothesis of Local Biaxial Ellipsoidal Hyperbolicity in the cross-range stepping, for reasons not completely clear. Variation in the proportioning between curvature assumptions had produced topographic maps that are in good mutual agreement but not realistic in appearance. They are severely banded parallel to the ground-range direction, most especially at small radar zenith angles. Numerical experimentation with the falsification of topography through incorrect decalibration as performed on a Gaussian hill suggests that the banding and its exaggeration at high radar incidence angles could easily be

  16. Integrating autonomous Problem Resolution Models with Remedy

    CERN Document Server

    Marquina, M A; Ramos, R

    2000-01-01

    This paper briefly defines the concept of Problem Resolution Model and shows possible approaches to the issues which may arise when integrating various PRMs to present a consistent view to the end user, despite of the peculiarities of each physical implementation. Integration refers to various autonomous PRMs having to interact as problems pass from one to another in the resolution flow. This process should be transparent to the user and internally there must be a way to track in which stage of the resolution process any problem is. This means addressing two different issues. On one side PRMs which are to be integrated need to comply with certain interface standards. These standards must ensure that problems exchanged between them can always be traced. On the other side problems owned by different PRMs should be presented to the end user under a homogeneous view. This means having an uniform criteria for automatic notification messages, a single reference point (www) where users can query the status of proble...

  17. Concept for integrated environmental monitoring. Scientific approach

    Energy Technology Data Exchange (ETDEWEB)

    Haber, W. [comp.; Schoenthaler, K.; Kerner, H.F.; Koeppel, J.; Spandau, L.

    1998-09-01

    Despite considerable expenditures for environmental protection and intensified efforts in the areas of environmental research and monitoring, environmental damage increasingly occurs, sometimes with global effects, largely due to the lack of early diagnosis. In the past few years various institutions have therefore demanded improvements in environmental monitoring. The Council of Experts on Environmental Issues (`Rat von Sachverstaendigen fuer Umweltfragen`, SRU), in particular, in its `Environmental Report` of 1987 and in its Special Report on `General Ecological Environmental Monitoring` (1990) presented far-reaching demands for a nationwide ecological early warning system which should integrate the various local, regional, national, and even global monitoring levels, and which should encompass an environmental monitoring of entire ecosystems at representative locations. This is aimed at creating the prerequisites for - detection of long-term gradual environmental change, - confirmation of refutation of initial assumptions regarding the causes of these environmental changes, - permitting decisions on preventive actions to stabilize or improve environmental conditions and - making it possible to assess the success of environmental protection policies. This report includes an abbreviated version and documentation of the conference on the `Concept for Integrated Environmental Monitoring` and the final report `Specification of the Concept for Integrated Environmental Monitoring from the Perspective of Nature Conservation`. (orig.)

  18. Model-Based Integration and Interpretation of Data

    DEFF Research Database (Denmark)

    Petersen, Johannes

    2004-01-01

    Data integration and interpretation plays a crucial role in supervisory control. The paper defines a set of generic inference steps for the data integration and interpretation process based on a three-layer model of system representations. The three-layer model is used to clarify the combination...... of constraint and object-centered representations of the work domain throwing new light on the basic principles underlying the data integration and interpretation process of Rasmussen's abstraction hierarchy as well as other model-based approaches combining constraint and object-centered representations. Based...

  19. Integrated Artificial Intelligence Approaches for Disease Diagnostics.

    Science.gov (United States)

    Vashistha, Rajat; Chhabra, Deepak; Shukla, Pratyoosh

    2018-06-01

    Mechanocomputational techniques in conjunction with artificial intelligence (AI) are revolutionizing the interpretations of the crucial information from the medical data and converting it into optimized and organized information for diagnostics. It is possible due to valuable perfection in artificial intelligence, computer aided diagnostics, virtual assistant, robotic surgery, augmented reality and genome editing (based on AI) technologies. Such techniques are serving as the products for diagnosing emerging microbial or non microbial diseases. This article represents a combinatory approach of using such approaches and providing therapeutic solutions towards utilizing these techniques in disease diagnostics.

  20. Integrating Visualizations into Modeling NEST Simulations.

    Science.gov (United States)

    Nowke, Christian; Zielasko, Daniel; Weyers, Benjamin; Peyser, Alexander; Hentschel, Bernd; Kuhlen, Torsten W

    2015-01-01

    Modeling large-scale spiking neural networks showing realistic biological behavior in their dynamics is a complex and tedious task. Since these networks consist of millions of interconnected neurons, their simulation produces an immense amount of data. In recent years it has become possible to simulate even larger networks. However, solutions to assist researchers in understanding the simulation's complex emergent behavior by means of visualization are still lacking. While developing tools to partially fill this gap, we encountered the challenge to integrate these tools easily into the neuroscientists' daily workflow. To understand what makes this so challenging, we looked into the workflows of our collaborators and analyzed how they use the visualizations to solve their daily problems. We identified two major issues: first, the analysis process can rapidly change focus which requires to switch the visualization tool that assists in the current problem domain. Second, because of the heterogeneous data that results from simulations, researchers want to relate data to investigate these effectively. Since a monolithic application model, processing and visualizing all data modalities and reflecting all combinations of possible workflows in a holistic way, is most likely impossible to develop and to maintain, a software architecture that offers specialized visualization tools that run simultaneously and can be linked together to reflect the current workflow, is a more feasible approach. To this end, we have developed a software architecture that allows neuroscientists to integrate visualization tools more closely into the modeling tasks. In addition, it forms the basis for semantic linking of different visualizations to reflect the current workflow. In this paper, we present this architecture and substantiate the usefulness of our approach by common use cases we encountered in our collaborative work.

  1. Integrating Visualizations into Modeling NEST Simulations

    Directory of Open Access Journals (Sweden)

    Christian eNowke

    2015-12-01

    Full Text Available Modeling large-scale spiking neural networks showing realistic biological behavior in their dynamics is a complex and tedious task. Since these networks consist of millions of interconnected neurons, their simulation produces an immense amount of data. In recent years it has become possible to simulate even larger networks. However, solutions to assist researchers in understanding the simulation's complex emergent behavior by means of visualization are still lacking. While developing tools to partially fill this gap, we encountered the challenge to integrate these tools easily into the neuroscientists' daily workflow. To understand what makes this so challenging, we looked into the workflows of our collaborators and analyzed how they use the visualizations to solve their daily problems. We identified two major issues: first, the analysis process can rapidly change focus which requires to switch the visualization tool that assists in the current problem domain. Second, because of the heterogeneous data that results from simulations, researchers want to relate data to investigate these effectively. Since a monolithic application model, processing and visualizing all data modalities and reflecting all combinations of possible workflows in a holistic way, is most likely impossible to develop and to maintain, a software architecture that offers specialized visualization tools that run simultaneously and can be linked together to reflect the current workflow, is a more feasible approach. To this end, we have developed a software architecture that allows neuroscientists to integrate visualization tools more closely into the modeling tasks. In addition, it forms the basis for semantic linking of different visualizations to reflect the current workflow. In this paper, we present this architecture and substantiate the usefulness of our approach by common use cases we encountered in our collaborative work.

  2. Integrating Visualizations into Modeling NEST Simulations

    Science.gov (United States)

    Nowke, Christian; Zielasko, Daniel; Weyers, Benjamin; Peyser, Alexander; Hentschel, Bernd; Kuhlen, Torsten W.

    2015-01-01

    Modeling large-scale spiking neural networks showing realistic biological behavior in their dynamics is a complex and tedious task. Since these networks consist of millions of interconnected neurons, their simulation produces an immense amount of data. In recent years it has become possible to simulate even larger networks. However, solutions to assist researchers in understanding the simulation's complex emergent behavior by means of visualization are still lacking. While developing tools to partially fill this gap, we encountered the challenge to integrate these tools easily into the neuroscientists' daily workflow. To understand what makes this so challenging, we looked into the workflows of our collaborators and analyzed how they use the visualizations to solve their daily problems. We identified two major issues: first, the analysis process can rapidly change focus which requires to switch the visualization tool that assists in the current problem domain. Second, because of the heterogeneous data that results from simulations, researchers want to relate data to investigate these effectively. Since a monolithic application model, processing and visualizing all data modalities and reflecting all combinations of possible workflows in a holistic way, is most likely impossible to develop and to maintain, a software architecture that offers specialized visualization tools that run simultaneously and can be linked together to reflect the current workflow, is a more feasible approach. To this end, we have developed a software architecture that allows neuroscientists to integrate visualization tools more closely into the modeling tasks. In addition, it forms the basis for semantic linking of different visualizations to reflect the current workflow. In this paper, we present this architecture and substantiate the usefulness of our approach by common use cases we encountered in our collaborative work. PMID:26733860

  3. An integrative approach to inferring biologically meaningful gene modules

    Directory of Open Access Journals (Sweden)

    Wang Kai

    2011-07-01

    Full Text Available Abstract Background The ability to construct biologically meaningful gene networks and modules is critical for contemporary systems biology. Though recent studies have demonstrated the power of using gene modules to shed light on the functioning of complex biological systems, most modules in these networks have shown little association with meaningful biological function. We have devised a method which directly incorporates gene ontology (GO annotation in construction of gene modules in order to gain better functional association. Results We have devised a method, Semantic Similarity-Integrated approach for Modularization (SSIM that integrates various gene-gene pairwise similarity values, including information obtained from gene expression, protein-protein interactions and GO annotations, in the construction of modules using affinity propagation clustering. We demonstrated the performance of the proposed method using data from two complex biological responses: 1. the osmotic shock response in Saccharomyces cerevisiae, and 2. the prion-induced pathogenic mouse model. In comparison with two previously reported algorithms, modules identified by SSIM showed significantly stronger association with biological functions. Conclusions The incorporation of semantic similarity based on GO annotation with gene expression and protein-protein interaction data can greatly enhance the functional relevance of inferred gene modules. In addition, the SSIM approach can also reveal the hierarchical structure of gene modules to gain a broader functional view of the biological system. Hence, the proposed method can facilitate comprehensive and in-depth analysis of high throughput experimental data at the gene network level.

  4. Continuum modeling an approach through practical examples

    CERN Document Server

    Muntean, Adrian

    2015-01-01

    This book develops continuum modeling skills and approaches the topic from three sides: (1) derivation of global integral laws together with the associated local differential equations, (2) design of constitutive laws and (3) modeling boundary processes. The focus of this presentation lies on many practical examples covering aspects such as coupled flow, diffusion and reaction in porous media or microwave heating of a pizza, as well as traffic issues in bacterial colonies and energy harvesting from geothermal wells. The target audience comprises primarily graduate students in pure and applied mathematics as well as working practitioners in engineering who are faced by nonstandard rheological topics like those typically arising in the food industry.

  5. Valuing groundwater: A practical approach for integrating ...

    African Journals Online (AJOL)

    ... Community (SADC) Groundwater and Drought Management Project. This methodology can be generally applied to groundwater management issues across the SADC region. The methodology is based upon an ecosystem services approach which considers all the potential services that groundwater provides, which can ...

  6. New Theoretical Approach Integrated Education and Technology

    Science.gov (United States)

    Ding, Gang

    2010-01-01

    The paper focuses on exploring new theoretical approach in education with development of online learning technology, from e-learning to u-learning and virtual reality technology, and points out possibilities such as constructing a new teaching ecological system, ubiquitous educational awareness with ubiquitous technology, and changing the…

  7. Alcoholism: integrating approaches to influence policy

    African Journals Online (AJOL)

    Adele

    Most importantly that these disorders are treatable and treatment can be cost effective. It is crucial that we continually challenge our assumptions of best treatment practices. Rehabilitation programs in the. USA have in the last decade radically changed their approach to treatment, providing most treatment in ambulatory reha ...

  8. Urban energy systems an integrated approach

    CERN Document Server

    Keirstead, James

    2013-01-01

    Energy demands of cities need to be met more sustainably. This book analyses the technical and social systems that satisfy these needs and asks how methods can be put into practice to achieve this.Drawing on analytical tools and case studies developed at Imperial College London, the book presents state-of-the-art techniques for examining urban energy systems as integrated systems of technologies, resources, and people.Case studies include:a history of the evolution of London's urban energy system, from pre-history to present daya history of the growth of d

  9. Design of Integrated Circuits Approaching Terahertz Frequencies

    DEFF Research Database (Denmark)

    Yan, Lei

    are designed based on the monolithic membrane supported Schottky diodes, which is under development at Chalmers University of Technology, Sweden. To simplify the baseband circuitry, the received IF signal from the subharmonic mixer is further amplified and downconverted to the DC range with a low noise...... heterodyne receivers with requirements of room temperature operation, low system complexity, and high sensitivity, monolithic integrated Schottky diode technology is chosen for the implementation of submillimeterwave components. The corresponding subharmonic mixer and multiplier for a THz radiometer system...

  10. Building integral projection models: a user's guide.

    Science.gov (United States)

    Rees, Mark; Childs, Dylan Z; Ellner, Stephen P

    2014-05-01

    In order to understand how changes in individual performance (growth, survival or reproduction) influence population dynamics and evolution, ecologists are increasingly using parameterized mathematical models. For continuously structured populations, where some continuous measure of individual state influences growth, survival or reproduction, integral projection models (IPMs) are commonly used. We provide a detailed description of the steps involved in constructing an IPM, explaining how to: (i) translate your study system into an IPM; (ii) implement your IPM; and (iii) diagnose potential problems with your IPM. We emphasize how the study organism's life cycle, and the timing of censuses, together determine the structure of the IPM kernel and important aspects of the statistical analysis used to parameterize an IPM using data on marked individuals. An IPM based on population studies of Soay sheep is used to illustrate the complete process of constructing, implementing and evaluating an IPM fitted to sample data. We then look at very general approaches to parameterizing an IPM, using a wide range of statistical techniques (e.g. maximum likelihood methods, generalized additive models, nonparametric kernel density estimators). Methods for selecting models for parameterizing IPMs are briefly discussed. We conclude with key recommendations and a brief overview of applications that extend the basic model. The online Supporting Information provides commented R code for all our analyses. © 2014 The Authors. Journal of Animal Ecology published by John Wiley & Sons Ltd on behalf of British Ecological Society.

  11. The Role of an Integrated Approach in Music Education Technology

    Directory of Open Access Journals (Sweden)

    Natalia Popovych

    2014-04-01

    Full Text Available The purpose of this paper is to justify the role of integrated approach to music education of students. This requires the implementation of a theoretical analysis of the meaning and importance of an integrated approach to music education and training, determination of didactic conditions of integrating the music education in schools and coverage of methods of arrangement of the complex relationships of the main types of educational and creative activity for students in music lessons. It is proved that an integrated approach to the music education process causes the appearance of new original teaching forms and techniques that brings the process to a new qualitative level, enriching the musical and creative abilities of students, enabling them to realize the artistic and aesthetic taste preferences, to achieve the integrity of musical and creative development and high levels of formation of aesthetic consciousness and music.

  12. Undergraduate hematology – a more integrated approach

    Directory of Open Access Journals (Sweden)

    Di Carlofelice MA

    2016-11-01

    Full Text Available Matteo A Di Carlofelice,* Jack FT Cope*Faculty of Medicine, Imperial College London, London, UK*These authors contributed equally to this workAs fellow medical students we read with great interest the article by Mandan et al1 proposing a dedicated hematology rotation. The authors highlight a gap in clinical hematology teaching, particularly compared to “conventional rotations”.1 Their suggestion has merits and we agree with most of the points raised; however, propose instead for us to build on current teaching as opposed to establishing a new rotation.The integration of theoretical and practical learning was concluded to be beneficial to both teacher and student by Wrenn and Wrenn.2 In the original article it is mentioned that “clinical experience allows students to comprehend and apply this knowledge in practice, enabling the all-important integration of their learning”.1 As we agree that hematology overlaps with other specialties and therefore requires a thorough understanding, we value how a clinical attachment would be useful to solidify lecture-based teaching.View the original paper by Mandan et al.

  13. Integral bridge abutment-to-approach slab connection.

    Science.gov (United States)

    2008-06-01

    The Iowa Department of Transportation has long recognized that approach slab pavements of integral abutment bridges are prone to settlement and cracking, which manifests as the "bump at the end of the bridge". A commonly recommended solution is to in...

  14. SESSION V: INTEGRATED APPROACHES IN LAND AND WATER ...

    African Journals Online (AJOL)

    SESSION V: INTEGRATED APPROACHES IN LAND AND WATER MANAGEMENT RESEARCH/LAND AND WATER MANAGEMENT ECONOMICS AND POLICY - Socioeconomic implications of improved forage species on smallholder farms in Kenya.

  15. Investigation on bulk water: Integral equation approach

    International Nuclear Information System (INIS)

    Adebayo, G.A.; Akinlade, O.; Hussain, L. A.; Forstmann, F.

    2001-08-01

    The static structure factor of water has been investigated using the central force model (CFM). Due to inadequacy of the HNC closure in describing the complex hydrogen bond interactions, we have used a bridge function obtained by adjusting the HH bond lengths. The modification results in an improvement in the theoretical structure factors. In addition to this, we examine other water models and provide a compilation of structural and thermodynamic results obtained from them. (author)

  16. An integrated approach for prioritized process improvement.

    Science.gov (United States)

    Vanteddu, Gangaraju; McAllister, Charles D

    2014-01-01

    The purpose of this paper is to propose an integrated framework to simultaneously identify and improve healthcare processes that are important from the healthcare provider's and patient's perspectives. A modified quality function deployment (QFD) chart is introduced to the field of healthcare quality assurance. A healthcare service example is used to demonstrate the utility of the proposed chart. The proposed framework is versatile and can be used in a wide variety of healthcare quality improvement contexts, wherein, two different perspectives are needed to be considered for identifying and improving critical healthcare processes. The modified QFD chart used in conjunction with the stacked Pareto chart will facilitate the identification of key performance metrics from the patient's and the hospital's perspectives. Subsequently, the chief contributory factors at different levels are identified in a very efficient manner. Healthcare quality improvement professionals will be able to use the proposed modified QFD chart in association with stacked Pareto chart for effective quality assurance.

  17. Regional Integrated Silvopastoral Approaches to Ecosystem Management Project

    OpenAIRE

    CIPAV (Centre For Research on Sustainable Agricultural Production Systems); CATIE (Centro Agronomico Tropical de Investigacion y Ensenanza); NITLAPAN

    2007-01-01

    Metadata only record The Regional Integrated Silvopastoral Approaches to Ecosystem Management Project introduces the payment for environmental services approach to silvopastoral farmers in Colombia, Costa Rica, and Nicaragua. The objectives of the project are to "demonstrate and measure a) the effects the introduction of payment incentives for environmental services to farmers on their adoption of integrated silvopastoral farming systems in degraded pasture lands; and b) the resulting impr...

  18. WE-G-BRD-04: BEST IN PHYSICS (JOINT IMAGING-THERAPY): An Integrated Model-Based Intrafractional Organ Motion Tracking Approach with Dynamic MRI in Head and Neck Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Chen, H; Dolly, S; Anastasio, M; Li, H; Wooten, H; Gay, H; Mutic, S; Thorstad, W; Li, H [Washington University School of Medicine, Saint Louis, MO (United States); Victoria, J; Dempsey, J [ViewRay incorporated, Oakwood Village, Ohio (United States); Ruan, S [University of Rouen, QuantIF - EA 4108 LITIS, Rouen (France); Low, D [Deparment of Radiation Oncology, University of California Los Angeles, Los Angeles, CA (United States)

    2015-06-15

    Purpose: In-treatment dynamic cine images, provided by the first commercially available MRI-guided radiotherapy system, allow physicians to observe intrafractional motion of head and neck (H&N) internal structures. Nevertheless, high anatomical complexity and relatively poor cine image contrast/resolution have complicated automatic intrafractional motion evaluation. We proposed an integrated model-based approach to automatically delineate and analyze moving structures from on-board cine images. Methods: The H&N upper airway, a complex and highly deformable region wherein severe internal motion often occurs, was selected as the target-to-be-tracked. To reliably capture its motion, a hierarchical structure model containing three statistical shapes (face, face-jaw, and face-jaw-palate) was first built from a set of manually delineated shapes using principal component analysis. An integrated model-fitting algorithm was then employed to align the statistical shapes to the first to-be-detected cine frame, and multi-feature level-set contour propagation was performed to identify the airway shape change in the remaining frames. Ninety sagittal cine MR image sets, acquired from three H&N cancer patients, were utilized to demonstrate this approach. Results: The tracking accuracy was validated by comparing the results to the average of two manual delineations in 20 randomly selected images from each patient. The resulting dice similarity coefficient (93.28+/−1.46 %) and margin error (0.49+/−0.12 mm) showed good agreement with the manual results. Intrafractional displacements of anterior, posterior, inferior, and superior airway boundaries were observed, with values of 2.62+/−2.92, 1.78+/−1.43, 3.51+/−3.99, and 0.68+/−0.89 mm, respectively. The H&N airway motion was found to vary across directions, fractions, and patients, and highly correlated with patients’ respiratory frequency. Conclusion: We proposed the integrated computational approach, which for the first

  19. Integrated Approach to Address Food and Nutrition Security in the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Integrated Approach to Address Food and Nutrition Security in the Philippines. Malnutrition remains a serious problem in the Philippines, especially among children. Could integrated garden and nutrition programs at schools help address the problem? An estimated 3 million children in the Philippines are undernourished.

  20. Investigating the effectiveness of a dynamic integrated approach to teacher professional development

    NARCIS (Netherlands)

    Antoniou, Panayiotis; Kyriakides, Leonidas; Creemers, Bert

    2011-01-01

    This paper argues that research on teacher professional development could be integrated with validated theoretical models of educational effectiveness research (EER). A dynamic integrated approach (DIA) to teacher professional development is proposed. The methods and results of a study comparing the

  1. Treatment of pathological gambling - integrative systemic model.

    Science.gov (United States)

    Mladenović, Ivica; Lažetić, Goran; Lečić-Toševski, Dušica; Dimitrijević, Ivan

    2015-03-01

    Pathological gambling was classified under impulse control disorders within the International Classification of Diseases (ICD-10) (WHO 1992), but the most recent Diagnostic and Statistical Manual, 5th edition (DSM-V), (APA 2013), has recognized pathological gambling as a first disorder within a new diagnostic category of behavioral addictions - Gambling disorder. Pathological gambling is a disorder in progression, and we hope that our experience in the treatment of pathological gambling in the Daily Hospital for Addictions at The Institute of Mental Health, through the original "Integrative - systemic model" would be of use to colleagues, dealing with this pathology. This model of treatment of pathological gambling is based on multi-systemic approach and it primarily represents an integration of family and cognitive-behavioral therapy, with traces of psychodynamic, existential and pharmacotherapy. The model is based on the book "Pathological gambling - with self-help manual" by Dr Mladenovic and Dr Lazetic, and has been designed in the form of a program that lasts 10 weeks in the intensive phase, and then continues for two years in the form of "extended treatment" ("After care"). The intensive phase is divided into three segments: educational, insight with initial changes and analysis of the achieved changes with the definition of plans and areas that need to be addressed in the extended treatment. "Extended treatment" lasts for two years in the form of group therapy, during which there is a second order change of the identified patient, but also of other family members. Pathological gambling has been treated in the form of systemic-family therapy for more than 10 years at the Institute of Mental Health (IMH), in Belgrade. For second year in a row the treatment is carried out by the modern "Integrative-systemic model". If abstinence from gambling witihin the period of one year after completion of the intensive phase of treatment is taken as the main criterion of

  2. A model for optimization of process integration investments under uncertainty

    International Nuclear Information System (INIS)

    Svensson, Elin; Stroemberg, Ann-Brith; Patriksson, Michael

    2011-01-01

    The long-term economic outcome of energy-related industrial investment projects is difficult to evaluate because of uncertain energy market conditions. In this article, a general, multistage, stochastic programming model for the optimization of investments in process integration and industrial energy technologies is proposed. The problem is formulated as a mixed-binary linear programming model where uncertainties are modelled using a scenario-based approach. The objective is to maximize the expected net present value of the investments which enables heat savings and decreased energy imports or increased energy exports at an industrial plant. The proposed modelling approach enables a long-term planning of industrial, energy-related investments through the simultaneous optimization of immediate and later decisions. The stochastic programming approach is also suitable for modelling what is possibly complex process integration constraints. The general model formulation presented here is a suitable basis for more specialized case studies dealing with optimization of investments in energy efficiency. -- Highlights: → Stochastic programming approach to long-term planning of process integration investments. → Extensive mathematical model formulation. → Multi-stage investment decisions and scenario-based modelling of uncertain energy prices. → Results illustrate how investments made now affect later investment and operation opportunities. → Approach for evaluation of robustness with respect to variations in probability distribution.

  3. Interventions to Promote an Integrated Approach to Public Health Problems: An Application to Childhood Obesity

    Directory of Open Access Journals (Sweden)

    Anna-Marie Hendriks

    2012-01-01

    Full Text Available Experts stress the need to bring the childhood obesity epidemic under control by means of an integrated approach. The implementation of such an approach requires the development of integrated enabling policies on public health by local governments. A prerequisite for developing such integrated public health policies is intersectoral collaboration. Since the development of integrated policies is still in its early stages, this study aimed to answer the following research question: “What interventions can promote intersectoral collaboration and the development of integrated health policies for the prevention of childhood obesity?” Data were collected through a literature search and observations of and interviews with stakeholders. Based on a theoretical framework, we categorized potential interventions that could optimize an integrated approach regarding children's physical activity and diet. The intervention categories included education, persuasion, incentivization, coercion, training, restriction, environmental restructuring, modeling, and enablement.

  4. Integrated approach for coastal hazards and risks in Sri Lanka

    Directory of Open Access Journals (Sweden)

    M. Garcin

    2008-06-01

    Full Text Available The devastating impact of the tsunami of 26 December 2004 on the shores of the Indian Ocean recalled the importance of knowledge and the taking into account of coastal hazards. Sri Lanka was one of the countries most affected by this tsunami (e.g. 30 000 dead, 1 million people homeless and 70% of the fishing fleet destroyed. Following this tsunami, as part of the French post-tsunami aid, a project to establish a Geographical Information System (GIS on coastal hazards and risks was funded. This project aims to define, at a pilot site, a methodology for multiple coastal hazards assessment that might be useful for the post-tsunami reconstruction and for development planning. This methodology could be applied to the whole coastline of Sri Lanka.

    The multi-hazard approach deals with very different coastal processes in terms of dynamics as well as in terms of return period. The first elements of this study are presented here. We used a set of tools integrating a GIS, numerical simulations and risk scenario modelling. While this action occurred in response to the crisis caused by the tsunami, it was decided to integrate other coastal hazards into the study. Although less dramatic than the tsunami these remain responsible for loss of life and damage. Furthermore, the establishment of such a system could not ignore the longer-term effects of climate change on coastal hazards in Sri Lanka.

    This GIS integrates the physical and demographic data available in Sri Lanka that is useful for assessing the coastal hazards and risks. In addition, these data have been used in numerical modelling of the waves generated during periods of monsoon as well as for the December 2004 tsunami. Risk scenarios have also been assessed for test areas and validated by field data acquired during the project. The results obtained from the models can be further integrated into the GIS and contribute to its enrichment and to help in better assessment and mitigation

  5. Strategic Technology Investment Analysis: An Integrated System Approach

    Science.gov (United States)

    Adumitroaie, V.; Weisbin, C. R.

    2010-01-01

    Complex technology investment decisions within NASA are increasingly difficult to make such that the end results are satisfying the technical objectives and all the organizational constraints. Due to a restricted science budget environment and numerous required technology developments, the investment decisions need to take into account not only the functional impact on the program goals, but also development uncertainties and cost variations along with maintaining a healthy workforce. This paper describes an approach for optimizing and qualifying technology investment portfolios from the perspective of an integrated system model. The methodology encompasses multi-attribute decision theory elements and sensitivity analysis. The evaluation of the degree of robustness of the recommended portfolio provides the decision-maker with an array of viable selection alternatives, which take into account input uncertainties and possibly satisfy nontechnical constraints. The methodology is presented in the context of assessing capability development portfolios for NASA technology programs.

  6. Food product design. An integrated approach

    NARCIS (Netherlands)

    Linnemann, A.R.; Boekel, van M.A.J.S.

    2007-01-01

    This book explains how to apply barrier technology in food production to improve product stability and the possibilities of modelling and statistics in food product design are elaborated. Attention is given to Life Cycle Assessment as a method to determine the environmental impact of a food from

  7. Integrating systems approaches into pharmaceutical sciences.

    NARCIS (Netherlands)

    Westerhoff, H.V.; Mosekilde, E.; Noe, C.; Clemensen, A.M.

    2008-01-01

    During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and BioSim, the major European Network of Excellence on Systems Biology, held a challenging conference on the use of mathematical models in the drug development process. More precisely, the purpose

  8. Marketing-oriented organizations: an integrated approach.

    Science.gov (United States)

    Stensrud, R; Arrington, B

    1988-03-01

    Organizations can be oriented toward marketing from a production, product, sales, or marketing perspective. Strategies, structures, and cultures, which reflect a company's basic orientation, must be integrated to ensure that marketing efforts communicate a clear corporate position. In a study of 31 hospitals, the Center for Health Services Education Research, St. Louis University, found that no hospital's organization fit neatly into a single category. For example, a hospital may have some service lines that were marketing oriented while other lines were production oriented. The majority of hospitals, however, were product oriented, focusing on productivity and financial performance rather than on market factors. The most effective sales orientation was observed in the for-profits. Their selling efforts, however, tended to be internally focused, with product development activities divorced from the planning and marketing functions. Only the for-profit hospitals showed the beginning of a marketing orientation. Developing a marketing orientation, especially in line divisions, requires a careful, well-orchestrated effort and the presence of several key factors: Access to capital and an emphasis on long-range planning and strategic spending The availability of hospital-specific market research. Key distribution channels. Talented middle managers. Up-to-date systems and structures equipped to serve new values and strategies. Leaders capable of communicating to the organization a vision of its role in the community.

  9. Mobile Technology Integrated Pedagogical Model

    Science.gov (United States)

    Khan, Arshia

    2014-01-01

    Integrated curricula and experiential learning are the main ingredients to the recipe to improve student learning in higher education. In the academic computer science world it is mostly assumed that this experiential learning takes place at a business as an internship experience. The intent of this paper is to schism the traditional understanding…

  10. Data integration, systems approach and multilevel description of complex biosystems

    Science.gov (United States)

    Hernández-Lemus, Enrique

    2013-12-01

    Recent years have witnessed the development of new quantitative approaches and theoretical tenets in the biological sciences. The advent of high throughput experiments in genomics, proteomics and electrophysiology (to cite just a few examples) have provided the researchers with unprecedented amounts of data to be analyzed. Large datasets, however can not provide the means to achieve a complete understanding of the underlying biological phenomena, unless they are supplied with a solid theoretical framework and with proper analytical tools. It is now widely accepted that by using and extending some of the paradigmatic principles of what has been called complex systems theory, some degree of advance in this direction can be attained. We will be presenting ways in which by using data integration techniques (linear, non-linear, combinatorial, graphical), multidimensional-multilevel descriptions (multifractal modeling, dimensionality reduction, computational learning), as well as an approach based in systems theory (interaction maps, probabilistic graphical models, non-equilibrium physics) have allowed us to better understand some problems in the interface of Statistical Physics and Computational Biology.

  11. AN INTEGRATED APPROACH FOR LINKED DATA BROWSING

    Directory of Open Access Journals (Sweden)

    W. Beek

    2017-07-01

    Full Text Available The Netherlands' Cadastre, Land Registry and Mapping Agency – in short Kadaster – collects and registers administrative and spatial data on property and the rights involved. Currently, the Kadaster is publishing its geo-spatial data assets as Linked Open Data. The Kadaster manages hundreds of datasets that describe hundreds of millions of geospatial objects, including all Dutch buildings, roads, and forests. The Kadaster exposes this large collection of data to thousands of daily users that operate from within different contexts and that need to be supported in different use cases. Therefore, Kadaster must offer diverse, yet complementary, approaches for browsing and exploring the data it publishes. Specifically, it supports the following paradigms for browsing and exploring its data assets: hierarchical browsing, graph navigation, faceted browsing, and tabular browsing. These paradigms are useful for different tasks, cover different use cases, and are implemented by reusing and/or developing Open Source libraries and applications.

  12. The Social Economy. An Integrating Approach

    Directory of Open Access Journals (Sweden)

    Sorin CACE

    2011-06-01

    Full Text Available The first part of this article analyses the normative approach of the social economy. The social economy is developed in order to create an alternative economic and social space for the people excluded from life necessities and, furthermore, it is not a recent phenomenon; it relies on historical practices which have developed over several centuries in order to meet people’s needs. The social economy institutions from Romania and Greece are then presented. The purpose is to show that clear regulations contribute to the acceptance of the social economy as an alternative and complementary form of producing social welfare. In order to accomplish the normative purposes of meeting life’s necessities and of changing the existing social conditions, the social economy actors must start to think of themselves not as individual agents, but as belonging to a large movement acting within the continuum between the market and state intervention for welfare production.

  13. Nutrigenomics: integrating genomic approaches into nutrition research.

    Science.gov (United States)

    Ferguson, Lynnette R

    2006-01-01

    It has been suggested that the supermarket of today will be the pharmacy of tomorrow. Such statements have been derived from recognition of our increasing ability to optimize nutrition, and maintain a state of good health through longer periods of life. The new field of nutrigenomics, which focuses on the interaction between bioactive dietary components and the genome, recognizes that current nutritional guidelines may be ideal for only a relatively small proportion of the population. There is good evidence that nutrition has significant influences on the expression of genes, and, likewise, genetic variation can have a significant effect on food intake, metabolic response to food, individual nutrient requirements, food safety, and the efficacy of disease-protective dietary factors. For example, a significant number of human studies in various areas are increasing the evidence for interactions between single nucleotide polymorphisms (SNPs) in various genes and the metabolic response to diet, including the risk of obesity. Many of the same genetic polymorphisms and dietary patterns that influence obesity or cardiovascular disease also affect cancer, since overweight individuals are at increased risk of cancer development. The control of food intake is profoundly affected by polymorphisms either in genes encoding taste receptors or in genes encoding a number of peripheral signaling peptides such as insulin, leptin, ghrelin, cholecystokinin, and corresponding receptors. Total dietary intake, and the satiety value of various foods, will profoundly influence the effects of these genes. Identifying key SNPs that are likely to influence the health of an individual provides an approach to understanding and, ultimately, to optimizing nutrition at the population or individual level. Traditional methods for identification of SNPs may involve consideration of individual variants, using methodologies such as restriction fragment length polymorphisms or quantitative real-time PCR

  14. Data assimilation in integrated hydrological modelling

    DEFF Research Database (Denmark)

    Rasmussen, Jørn

    Integrated hydrological models are useful tools for water resource management and research, and advances in computational power and the advent of new observation types has resulted in the models generally becoming more complex and distributed. However, the models are often characterized by a high...... degree of parameterization which results in significant model uncertainty which cannot be reduced much due to observations often being scarce and often taking the form of point measurements. Data assimilation shows great promise for use in integrated hydrological models , as it allows for observations...... to be efficiently combined with models to improve model predictions, reduce uncertainty and estimate model parameters. In this thesis, a framework for assimilating multiple observation types and updating multiple components and parameters of a catchment scale integrated hydrological model is developed and tested...

  15. The dynamics of multimodal integration: The averaging diffusion model.

    Science.gov (United States)

    Turner, Brandon M; Gao, Juan; Koenig, Scott; Palfy, Dylan; L McClelland, James

    2017-12-01

    We combine extant theories of evidence accumulation and multi-modal integration to develop an integrated framework for modeling multimodal integration as a process that unfolds in real time. Many studies have formulated sensory processing as a dynamic process where noisy samples of evidence are accumulated until a decision is made. However, these studies are often limited to a single sensory modality. Studies of multimodal stimulus integration have focused on how best to combine different sources of information to elicit a judgment. These studies are often limited to a single time point, typically after the integration process has occurred. We address these limitations by combining the two approaches. Experimentally, we present data that allow us to study the time course of evidence accumulation within each of the visual and auditory domains as well as in a bimodal condition. Theoretically, we develop a new Averaging Diffusion Model in which the decision variable is the mean rather than the sum of evidence samples and use it as a base for comparing three alternative models of multimodal integration, allowing us to assess the optimality of this integration. The outcome reveals rich individual differences in multimodal integration: while some subjects' data are consistent with adaptive optimal integration, reweighting sources of evidence as their relative reliability changes during evidence integration, others exhibit patterns inconsistent with optimality.

  16. Advances in NLTE modeling for integrated simulations

    Science.gov (United States)

    Scott, H. A.; Hansen, S. B.

    2010-01-01

    The last few years have seen significant progress in constructing the atomic models required for non-local thermodynamic equilibrium (NLTE) simulations. Along with this has come an increased understanding of the requirements for accurately modeling the ionization balance, energy content and radiative properties of different atomic species for a wide range of densities and temperatures. Much of this progress is the result of a series of workshops dedicated to comparing the results from different codes and computational approaches applied to a series of test problems. The results of these workshops emphasized the importance of atomic model completeness, especially in doubly-excited states and autoionization transitions, to calculating ionization balance, and the importance of accurate, detailed atomic data to producing reliable spectra. We describe a simple screened-hydrogenic model that calculates NLTE ionization balance with sufficient accuracy, at a low enough computational cost for routine use in radiation-hydrodynamics codes. The model incorporates term splitting, Δ n = 0 transitions, and approximate UTA widths for spectral calculations, with results comparable to those of much more detailed codes. Simulations done with this model have been increasingly successful at matching experimental data for laser-driven systems and hohlraums. Accurate and efficient atomic models are just one requirement for integrated NLTE simulations. Coupling the atomic kinetics to hydrodynamics and radiation transport constrains both discretizations and algorithms to retain energy conservation, accuracy and stability. In particular, the strong coupling between radiation and populations can require either very short time steps or significantly modified radiation transport algorithms to account for NLTE material response. Considerations such as these continue to provide challenges for NLTE simulations.

  17. Advances in NLTE Modeling for Integrated Simulations

    International Nuclear Information System (INIS)

    Scott, H.A.; Hansen, S.B.

    2009-01-01

    The last few years have seen significant progress in constructing the atomic models required for non-local thermodynamic equilibrium (NLTE) simulations. Along with this has come an increased understanding of the requirements for accurately modeling the ionization balance, energy content and radiative properties of different elements for a wide range of densities and temperatures. Much of this progress is the result of a series of workshops dedicated to comparing the results from different codes and computational approaches applied to a series of test problems. The results of these workshops emphasized the importance of atomic model completeness, especially in doubly excited states and autoionization transitions, to calculating ionization balance, and the importance of accurate, detailed atomic data to producing reliable spectra. We describe a simple screened-hydrogenic model that calculates NLTE ionization balance with surprising accuracy, at a low enough computational cost for routine use in radiation-hydrodynamics codes. The model incorporates term splitting, Δn = 0 transitions, and approximate UTA widths for spectral calculations, with results comparable to those of much more detailed codes. Simulations done with this model have been increasingly successful at matching experimental data for laser-driven systems and hohlraums. Accurate and efficient atomic models are just one requirement for integrated NLTE simulations. Coupling the atomic kinetics to hydrodynamics and radiation transport constrains both discretizations and algorithms to retain energy conservation, accuracy and stability. In particular, the strong coupling between radiation and populations can require either very short timesteps or significantly modified radiation transport algorithms to account for NLTE material response. Considerations such as these continue to provide challenges for NLTE simulations.

  18. Integrability in three dimensions: Algebraic Bethe ansatz for anyonic models

    Directory of Open Access Journals (Sweden)

    Sh. Khachatryan

    2015-10-01

    Full Text Available We extend basic properties of two dimensional integrable models within the Algebraic Bethe Ansatz approach to 2+1 dimensions and formulate the sufficient conditions for the commutativity of transfer matrices of different spectral parameters, in analogy with Yang–Baxter or tetrahedron equations. The basic ingredient of our models is the R-matrix, which describes the scattering of a pair of particles over another pair of particles, the quark-anti-quark (meson scattering on another quark-anti-quark state. We show that the Kitaev model belongs to this class of models and its R-matrix fulfills well-defined equations for integrability.

  19. An integrated, multi-sensing approach to describe the dynamic relations between turbulence, fluid-forces, and reconfiguration of a submerged plant model in steady flows.

    Science.gov (United States)

    Henry, Pierre-Yves; Aberle, Jochen; Dijkstra, Jasper; Myrhaug, Dag

    2016-04-01

    Aquatic vegetation plays a vital role in ecohydrological systems regulating many physical, chemical, and biological processes across a wide range of spatial and temporal scales. As a consequence, plant-flow interactions are of particular interest to a wide range of disciplines. While early studies of the interactions between vegetation and flowing water employed simplified and non-flexible structures such as rigid cylinders, recent studies have included flexible plants to identify the main characteristics of the hydrodynamics of vegetated flows. However, the description of plant reconfiguration has often been based on a static approach, i.e. considering the plant's deformation under a static load and neglecting turbulent fluctuations. Correlations between drag fluctuations, plant movements, and upstream turbulence were recently established showing that shear layer turbulence at the surface of the different plant elements (such as blades or stems) can contribute significantly to the dynamic behaviour of the plant. However, the relations between plant movement and force fluctuations might change under varying flow velocities, and although this point is crucial for mixing processes and plant dislodgement by fatigue, these aspects of fluid-structure interactions applied to aquatic vegetation remain largely unexplored. Using an innovative combination of sensing techniques in one set of experiments, this study investigates the relations between turbulence, fluctuating fluid forces and movements of a flexible cylindrical plant surrogate. A silicone-based flexible cylinder was attached at the bottom of a 1m wide flume in fully-developed uniform flow. The lower 22 cm of the plant surrogate were made of plain flexible silicone, while the higher 13cm included a casted rigid sensor, measuring accelerations at the tip of the surrogate. Forces were sampled at high frequencies at the surrogate's base by a 6-degrees-of-freedom force/torque sensor measuring down to the gram

  20. Recent developments in the path integral approach to anomalies

    International Nuclear Information System (INIS)

    Fujikawa, Kazuo.

    1986-08-01

    After a brief summary of the path integral approach to anomalous identities, some of the recent developments in this approach are discussed. The topics discussed include (i) Construction of the effective action by means of the covariant current, (ii) Gauss law constraint in anomalous gauge theories, (iii) Path integral approach to anomalies in superconformal transformations, (iv) Conformal and ghost number anomalies in string theory in analogy with the instanton calculation, (v) Covariant local Lorentz anomaly and its connection with the mathematical construction of the consistent anomaly. (author)

  1. High resolution integral holography using Fourier ptychographic approach.

    Science.gov (United States)

    Li, Zhaohui; Zhang, Jianqi; Wang, Xiaorui; Liu, Delian

    2014-12-29

    An innovative approach is proposed for calculating high resolution computer generated integral holograms by using the Fourier Ptychographic (FP) algorithm. The approach initializes a high resolution complex hologram with a random guess, and then stitches together low resolution multi-view images, synthesized from the elemental images captured by integral imaging (II), to recover the high resolution hologram through an iterative retrieval with FP constrains. This paper begins with an analysis of the principle of hologram synthesis from multi-projections, followed by an accurate determination of the constrains required in the Fourier ptychographic integral-holography (FPIH). Next, the procedure of the approach is described in detail. Finally, optical reconstructions are performed and the results are demonstrated. Theoretical analysis and experiments show that our proposed approach can reconstruct 3D scenes with high resolution.

  2. An Integrated Management Approach to Atrial Fibrillation.

    Science.gov (United States)

    Carter, Lindsey; Gardner, Martin; Magee, Kirk; Fearon, Ann; Morgulis, Inna; Doucette, Steve; Sapp, John L; Gray, Chris; Abdelwahab, Amir; Parkash, Ratika

    2016-01-25

    Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia resulting in mortality and morbidity. Gaps in oral anticoagulation and education of patients regarding AF have been identified as areas that require improvement. A before-and-after study of 433 patients with newly diagnosed AF in the 3 emergency departments in Nova Scotia from January 1, 2011 until January 31, 2014 was performed. The "before" phase underwent the usual-care pathway for AF management; the "after" phase was enrolled in a nurse-run, physician-supervised AF clinic. The primary outcome was a composite of death, cardiovascular hospitalization, and AF-related emergency department visits. A propensity analysis was performed to account for differences in baseline characteristics. A total of 185 patients were enrolled into the usual-care group, and 228 patients were enrolled in the AF clinic group. The mean age was 64±15 years and 44% were women. In a propensity-matched analysis, the primary outcome occurred in 44 (26.2%) patients in the usual-care group and 29 (17.3%) patients in the AF clinic group (odds ratio 0.71; 95% CI [0.59, 1]; P=0.049) at 12 months. Prescription of oral anticoagulation was increased in the CHADS2 ≥2 group (88.4% in the AF clinic versus 58.5% in the usual-care group, Pmanagement approach for the burgeoning population of AF may provide an overall benefit to cardiovascular morbidity and mortality. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  3. A transdisciplinary approach for supporting the integration of ecosystem services into land and water management

    Science.gov (United States)

    Fatt Siew, Tuck; Döll, Petra

    2015-04-01

    Transdisciplinary approaches are useful for supporting integrated land and water management. However, the implementation of the approach in practice to facilitate the co-production of useable socio-hydrological (and -ecological) knowledge among scientists and stakeholders is challenging. It requires appropriate methods to bring individuals with diverse interests and needs together and to integrate their knowledge for generating shared perspectives/understanding, identifying common goals, and developing actionable management strategies. The approach and the methods need, particularly, to be adapted to the local political and socio-cultural conditions. To demonstrate how knowledge co-production and integration can be done in practice, we present a transdisciplinary approach which has been implemented and adapted for supporting land and water management that takes ecosystem services into account in an arid region in northwestern China. Our approach comprises three steps: (1) stakeholder analysis and interdisciplinary knowledge integration, (2) elicitation of perspectives of scientists and stakeholders, scenario development, and identification of management strategies, and (3) evaluation of knowledge integration and social learning. Our adapted approach has enabled interdisciplinary and cross-sectoral communication among scientists and stakeholders. Furthermore, the application of a combination of participatory methods, including actor modeling, Bayesian Network modeling, and participatory scenario development, has contributed to the integration of system, target, and transformation knowledge of involved stakeholders. The realization of identified management strategies is unknown because other important and representative decision makers have not been involved in the transdisciplinary research process. The contribution of our transdisciplinary approach to social learning still needs to be assessed.

  4. Integrated Approach to Monitor Flow Accelerated Corrosion

    International Nuclear Information System (INIS)

    Lee, Na Young; Ryu, Kyung Ha; Lee, Seung Gi; Hwang, Il Soon

    2005-01-01

    Aged nuclear piping has been reported to undergo corrosion-induced accelerated failures, often without giving signatures to current inspection campaigns. Flow Accelerated Corrosion (FAC), one of the hot issues in aged piping occurs due to many combined parameters. Therefore, we need to monitor as many parameters as possible, and that cover wide area, since we don' know where the FAC occurs. Therefore, we need diverse sensors which can cover wide area in the on-line application. Since FAC is a combined phenomenon, we reviewed parameters important to FAC occurrence, and then surveyed applicable sensors. First, we identified feasibility by analytical way, and then we developed electrochemical sensors for high temperature application. We also introduced mechanical monitoring system, which gathers thickness-dependent signals. These signals are indirect, and thus we need an interface which converts monitored results to an identical parameter. We introduced wearing rate model, which accepts the electrochemical parameters as inputs. By the model, we can predict the wearing rate and then we can compare the monitored electrochemical parameters with the thickness monitoring result as a validation. After the preliminary tests, we developed the FAC simulation test loop of high temperature and pressure, which is similar to the secondary part of the NPP. We changed pH and dissolved oxygen of the developed test loop to accelerate FAC. To support the validation of the monitored results, we also adopted high temperature UT, which shows good resolution in the testing environment. By this way, all the monitored results can be compared in terms of thickness

  5. Integrating an artificial intelligence approach with k-means clustering to model groundwater salinity: the case of Gaza coastal aquifer (Palestine)

    Science.gov (United States)

    Alagha, Jawad S.; Seyam, Mohammed; Md Said, Md Azlin; Mogheir, Yunes

    2017-12-01

    Artificial intelligence (AI) techniques have increasingly become efficient alternative modeling tools in the water resources field, particularly when the modeled process is influenced by complex and interrelated variables. In this study, two AI techniques—artificial neural networks (ANNs) and support vector machine (SVM)—were employed to achieve deeper understanding of the salinization process (represented by chloride concentration) in complex coastal aquifers influenced by various salinity sources. Both models were trained using 11 years of groundwater quality data from 22 municipal wells in Khan Younis Governorate, Gaza, Palestine. Both techniques showed satisfactory prediction performance, where the mean absolute percentage error (MAPE) and correlation coefficient ( R) for the test data set were, respectively, about 4.5 and 99.8% for the ANNs model, and 4.6 and 99.7% for SVM model. The performances of the developed models were further noticeably improved through preprocessing the wells data set using a k-means clustering method, then conducting AI techniques separately for each cluster. The developed models with clustered data were associated with higher performance, easiness and simplicity. They can be employed as an analytical tool to investigate the influence of input variables on coastal aquifer salinity, which is of great importance for understanding salinization processes, leading to more effective water-resources-related planning and decision making.

  6. Model approach brings multi-level success.

    Science.gov (United States)

    Howell, Mark

    2012-08-01

    n an article that first appeared in US magazine, Medical Construction & Design, Mark Howell, senior vice-president of Skanska USA Building, based in Seattle, describes the design and construction of a new nine-storey, 350,000 ft2 extension to the Good Samaritan Hospital in Puyallup, Washington state. He explains how the use of an Integrated Project Delivery (IPD) approach by the key players, and extensive use of building information modelling (BIM), combined to deliver a healthcare facility that he believes should meet the needs of patients, families, and the clinical care team, 'well into the future'.

  7. Integrated climate and hydrology modelling

    DEFF Research Database (Denmark)

    Larsen, Morten Andreas Dahl

    global warming and increased frequency of extreme events. The skill in developing projections of both the present and future climate depends essentially on the ability to numerically simulate the processes of atmospheric circulation, hydrology, energy and ecology. Previous modelling efforts of climate...... and hydrology have used each model component in an offline mode where the models are run in sequential steps and one model serves as a boundary condition or data input source to the other. Within recent years a new field of research has emerged where efforts have been made to dynamically couple existing climate...... and hydrology models to more directly include the interaction between the atmosphere and the land surface. The present PhD study is motivated by an ambition of developing and applying a modelling tool capable of including the interaction and feedback mechanisms between the atmosphere and the land surface...

  8. A new Gauss quadrature for multicentre integrals over STOs in the Gaussian integral transform approach

    International Nuclear Information System (INIS)

    Bouferguene, Ahmed

    2005-01-01

    When computing multicentre integrals over Slater-type orbitals (STOs) by means of the Shavitt and Karplus Gaussian integral transforms (Shavitt and Karplus 1962 J. Chem. Phys. 36 550), one usually ends up with a multiple integral of the form ∫ 0 1 du ∫ 0 1 dv ...∫ 0 ∞ dz F(u, v, ..., z) (Shavitt and Karplus 1965 J. Chem. Phys. 43 398) in which all the integrals are inter-related. The most widely used approach for computing such an integral is to apply a product of Gauss-Legendre quadratures for the integrals over [0, 1] while the semi-infinite term is evaluated by a special procedure. Although numerous approaches have been developed to accurately perform the integration over [0, ∞) efficiently, it is the aim of this work to add a new tool that could be of some benefit in carrying out the hard task of multicentre integrals over STOs. The new approach relies on a special Gauss quadrature referred to as Gauss-Bessel to accurately evaluate the semi-infinite integral of interest. In this work, emphasis is put on accuracy rather than efficiency since its aim is essentially to bring a proof of concept showing that Gauss-Bessel quadrature can successfully be applied in the context of multicentre integrals over STOs. The obtained accuracy is comparable to that obtained with other methods available in the literature

  9. Systematic and Integrated Approach to Tropical Cyclone Track Forecasting. Part 3. Traits Knowledge Base for JTWC Track Forecast Models in the Western North Pacific

    National Research Council Canada - National Science Library

    Carr, Lester

    1999-01-01

    .... The indications and characteristics of these frequently recurring error mechanisms in the forecast tracks and fields of the models are thoroughly documented and one or more illustrative case studies...

  10. A multiscale modeling approach for biomolecular systems

    Energy Technology Data Exchange (ETDEWEB)

    Bowling, Alan, E-mail: bowling@uta.edu; Haghshenas-Jaryani, Mahdi, E-mail: mahdi.haghshenasjaryani@mavs.uta.edu [The University of Texas at Arlington, Department of Mechanical and Aerospace Engineering (United States)

    2015-04-15

    This paper presents a new multiscale molecular dynamic model for investigating the effects of external interactions, such as contact and impact, during stepping and docking of motor proteins and other biomolecular systems. The model retains the mass properties ensuring that the result satisfies Newton’s second law. This idea is presented using a simple particle model to facilitate discussion of the rigid body model; however, the particle model does provide insights into particle dynamics at the nanoscale. The resulting three-dimensional model predicts a significant decrease in the effect of the random forces associated with Brownian motion. This conclusion runs contrary to the widely accepted notion that the motor protein’s movements are primarily the result of thermal effects. This work focuses on the mechanical aspects of protein locomotion; the effect ATP hydrolysis is estimated as internal forces acting on the mechanical model. In addition, the proposed model can be numerically integrated in a reasonable amount of time. Herein, the differences between the motion predicted by the old and new modeling approaches are compared using a simplified model of myosin V.

  11. An innovative modeling approach using Qual2K and HEC-RAS integration to assess the impact of tidal effect on River Water quality simulation.

    Science.gov (United States)

    Fan, Chihhao; Ko, Chun-Han; Wang, Wei-Shen

    2009-04-01

    Water quality modeling has been shown to be a useful tool in strategic water quality management. The present study combines the Qual2K model with the HEC-RAS model to assess the water quality of a tidal river in northern Taiwan. The contaminant loadings of biochemical oxygen demand (BOD), ammonia nitrogen (NH(3)-N), total phosphorus (TP), and sediment oxygen demand (SOD) are utilized in the Qual2K simulation. The HEC-RAS model is used to: (i) estimate the hydraulic constants for atmospheric re-aeration constant calculation; and (ii) calculate the water level profile variation to account for concentration changes as a result of tidal effect. The results show that HEC-RAS-assisted Qual2K simulations taking tidal effect into consideration produce water quality indices that, in general, agree with the monitoring data of the river. Comparisons of simulations with different combinations of contaminant loadings demonstrate that BOD is the most import contaminant. Streeter-Phelps simulation (in combination with HEC-RAS) is also performed for comparison, and the results show excellent agreement with the observed data. This paper is the first report of the innovative use of a combination of the HEC-RAS model and the Qual2K model (or Streeter-Phelps equation) to simulate water quality in a tidal river. The combination is shown to provide an alternative for water quality simulation of a tidal river when available dynamic-monitoring data are insufficient to assess the tidal effect of the river.

  12. On impulsive integrated pest management models with stochastic effects.

    Science.gov (United States)

    Akman, Olcay; Comar, Timothy D; Hrozencik, Daniel

    2015-01-01

    We extend existing impulsive differential equation models for integrated pest management (IPM) by including stage structure for both predator and prey as well as by adding stochastic elements in the birth rate of the prey. Based on our model, we propose an approach that incorporates various competing stochastic components. This approach enables us to select a model with optimally determined weights for maximum accuracy and precision in parameter estimation. This is significant in the case of IPM because the proposed model accommodates varying unknown environmental and climatic conditions, which affect the resources needed for pest eradication.

  13. Model Identification of Integrated ARMA Processes

    Science.gov (United States)

    Stadnytska, Tetiana; Braun, Simone; Werner, Joachim

    2008-01-01

    This article evaluates the Smallest Canonical Correlation Method (SCAN) and the Extended Sample Autocorrelation Function (ESACF), automated methods for the Autoregressive Integrated Moving-Average (ARIMA) model selection commonly available in current versions of SAS for Windows, as identification tools for integrated processes. SCAN and ESACF can…

  14. Multiple Model Approaches to Modelling and Control,

    DEFF Research Database (Denmark)

    appeal in building systems which operate robustly over a wide range of operating conditions by decomposing them into a number of simplerlinear modelling or control problems, even for nonlinear modelling or control problems. This appeal has been a factor in the development of increasinglypopular `local...... to problems in the process industries, biomedical applications and autonomoussystems. The successful application of the ideas to demanding problems is already encouraging, but creative development of the basic framework isneeded to better allow the integration of human knowledge with automated learning....... The underlying question is `How should we partition the system - what is `local'?'. This book presents alternative ways of bringing submodels together,which lead to varying levels of performance and insight. Some are further developed for autonomous learning of parameters from data, while others havefocused...

  15. Using integrated environmental modeling to automate a process-based Quantitative Microbial Risk Assessment

    Science.gov (United States)

    Integrated Environmental Modeling (IEM) organizes multidisciplinary knowledge that explains and predicts environmental-system response to stressors. A Quantitative Microbial Risk Assessment (QMRA) is an approach integrating a range of disparate data (fate/transport, exposure, an...

  16. Using Integrated Environmental Modeling to Automate a Process-Based Quantitative Microbial Risk Assessment (presentation)

    Science.gov (United States)

    Integrated Environmental Modeling (IEM) organizes multidisciplinary knowledge that explains and predicts environmental-system response to stressors. A Quantitative Microbial Risk Assessment (QMRA) is an approach integrating a range of disparate data (fate/transport, exposure, and...

  17. Integrated Giant Magnetoresistance Technology for Approachable Weak Biomagnetic Signal Detections.

    Science.gov (United States)

    Shen, Hui-Min; Hu, Liang; Fu, Xin

    2018-01-07

    With the extensive applications of biomagnetic signals derived from active biological tissue in both clinical diagnoses and human-computer-interaction, there is an increasing need for approachable weak biomagnetic sensing technology. The inherent merits of giant magnetoresistance (GMR) and its high integration with multiple technologies makes it possible to detect weak biomagnetic signals with micron-sized, non-cooled and low-cost sensors, considering that the magnetic field intensity attenuates rapidly with distance. This paper focuses on the state-of-art in integrated GMR technology for approachable biomagnetic sensing from the perspective of discipline fusion between them. The progress in integrated GMR to overcome the challenges in weak biomagnetic signal detection towards high resolution portable applications is addressed. The various strategies for 1/ f noise reduction and sensitivity enhancement in integrated GMR technology for sub-pT biomagnetic signal recording are discussed. In this paper, we review the developments of integrated GMR technology for in vivo/vitro biomagnetic source imaging and demonstrate how integrated GMR can be utilized for biomagnetic field detection. Since the field sensitivity of integrated GMR technology is being pushed to fT/Hz 0.5 with the focused efforts, it is believed that the potential of integrated GMR technology will make it preferred choice in weak biomagnetic signal detection in the future.

  18. Approaches to cancer assessment in EPA's Integrated Risk Information System

    International Nuclear Information System (INIS)

    Gehlhaus, Martin W.; Gift, Jeffrey S.; Hogan, Karen A.; Kopylev, Leonid; Schlosser, Paul M.; Kadry, Abdel-Razak

    2011-01-01

    The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) Program develops assessments of health effects that may result from chronic exposure to chemicals in the environment. The IRIS database contains more than 540 assessments. When supported by available data, IRIS assessments provide quantitative analyses of carcinogenic effects. Since publication of EPA's 2005 Guidelines for Carcinogen Risk Assessment, IRIS cancer assessments have implemented new approaches recommended in these guidelines and expanded the use of complex scientific methods to perform quantitative dose-response assessments. Two case studies of the application of the mode of action framework from the 2005 Cancer Guidelines are presented in this paper. The first is a case study of 1,2,3-trichloropropane, as an example of a chemical with a mutagenic mode of carcinogenic action thus warranting the application of age-dependent adjustment factors for early-life exposure; the second is a case study of ethylene glycol monobutyl ether, as an example of a chemical with a carcinogenic action consistent with a nonlinear extrapolation approach. The use of physiologically based pharmacokinetic (PBPK) modeling to quantify interindividual variability and account for human parameter uncertainty as part of a quantitative cancer assessment is illustrated using a case study involving probabilistic PBPK modeling for dichloromethane. We also discuss statistical issues in assessing trends and model fit for tumor dose-response data, analysis of the combined risk from multiple types of tumors, and application of life-table methods for using human data to derive cancer risk estimates. These issues reflect the complexity and challenges faced in assessing the carcinogenic risks from exposure to environmental chemicals, and provide a view of the current trends in IRIS carcinogenicity risk assessment.

  19. Approaches to cancer assessment in EPA's Integrated Risk Information System.

    Science.gov (United States)

    Gehlhaus, Martin W; Gift, Jeffrey S; Hogan, Karen A; Kopylev, Leonid; Schlosser, Paul M; Kadry, Abdel-Razak

    2011-07-15

    The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) Program develops assessments of health effects that may result from chronic exposure to chemicals in the environment. The IRIS database contains more than 540 assessments. When supported by available data, IRIS assessments provide quantitative analyses of carcinogenic effects. Since publication of EPA's 2005 Guidelines for Carcinogen Risk Assessment, IRIS cancer assessments have implemented new approaches recommended in these guidelines and expanded the use of complex scientific methods to perform quantitative dose-response assessments. Two case studies of the application of the mode of action framework from the 2005 Cancer Guidelines are presented in this paper. The first is a case study of 1,2,3-trichloropropane, as an example of a chemical with a mutagenic mode of carcinogenic action thus warranting the application of age-dependent adjustment factors for early-life exposure; the second is a case study of ethylene glycol monobutyl ether, as an example of a chemical with a carcinogenic action consistent with a nonlinear extrapolation approach. The use of physiologically based pharmacokinetic (PBPK) modeling to quantify interindividual variability and account for human parameter uncertainty as part of a quantitative cancer assessment is illustrated using a case study involving probabilistic PBPK modeling for dichloromethane. We also discuss statistical issues in assessing trends and model fit for tumor dose-response data, analysis of the combined risk from multiple types of tumors, and application of life-table methods for using human data to derive cancer risk estimates. These issues reflect the complexity and challenges faced in assessing the carcinogenic risks from exposure to environmental chemicals, and provide a view of the current trends in IRIS carcinogenicity risk assessment. Copyright © 2011. Published by Elsevier Inc.

  20. Development of a generalized integral jet model

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan; Kessler, A.; Markert, Frank

    2017-01-01

    model is needed to describe the rapid combustion of the flammable part of the plume (flash fire) and a third model has to be applied for the remaining jet fire. The objective of this paper is to describe the first steps of the development of an integral-type model describing the transient development...

  1. An Integrative Model of Internationalization Strategies

    DEFF Research Database (Denmark)

    Li, Xin; Gammelgaard, Jens

    2012-01-01

    This paper critically reviews the ownership, location, and internalization (OLI) model, and the Uppsala internationalization process (UIP) framework. Both the OLI model and the UIP model ignore to incorporate the insights of each other and fail to include corporate entrepreneurship...... such as corporate entrepreneurship, institutional environment, and regulatory focus in an integrated framework helps to explain firm internationalization....

  2. A stochastic-programming approach to integrated asset and liability ...

    African Journals Online (AJOL)

    This increase in complexity has provided an impetus for the investigation into integrated asset- and liability-management frameworks that could realistically address dynamic portfolio allocation in a risk-controlled way. In this paper the authors propose a multi-stage dynamic stochastic-programming model for the integrated ...

  3. Use of an integrated modelling and simulation approach to develop a simplified peginterferon alfa-2a dosing regimen for children with hepatitis C.

    Science.gov (United States)

    Brennan, Barbara J; Lemenuel-Diot, Annabelle; Snoeck, Eric; McKenna, Michael; Solsky, Jonathan; Wat, Cynthia; Mallalieu, Navita L

    2016-04-01

    The aim of the study was to simplify the dosing regimen of peginterferon alfa-2a in paediatric patients with chronic hepatitis C. A population pharmacokinetic (PK) model was developed using PK data from 14 children aged 2-8 years and 402 adults. Simulations were produced to identify a simplified dosing regimen that would provide exposures similar to those observed in the paediatric clinical trials and in the range known to be safe/efficacious in adults. Model predictions were evaluated against observed adult and paediatric data to reinforce confidence of the proposed dosing regimen. The final model was a two compartment model with a zero order resorption process. Covariates included a linear influence of body surface area (BSA) on apparent oral clearance (CL/F) and a linear influence of body weight on apparent volume of distribution of the central compartment (V1 /F). A simplified dosing regimen was developed which is expected to provide exposures in children aged ≥5 years similar to the dosing formula used in the paediatric clinical trial and within the range that is safe/efficacious in adults. This simplified regimen is approved in the EU and in other countries for the treatment of chronic hepatitis C in treatment-naive children/adolescents aged ≥5 years in combination with ribavirin. Pre-existing adult PK data were combined with relatively limited paediatric PK data to develop a PK model able to predict exposure in both populations adequately. This provided increased confidence in characterizing PK in children and helped in the development of a simplified dosing regimen of peginterferon alfa-2a in paediatric patients. © 2015 The British Pharmacological Society.

  4. Science Teachers’ Pedagogical Content Knowledge and Integrated Approach

    Science.gov (United States)

    Adi Putra, M. J.; Widodo, A.; Sopandi, W.

    2017-09-01

    The integrated approach refers to the stages of pupils’ psychological development. Unfortunately, the competences which are designed into the curriculum is not appropriate with the child development. This Manuscript presents PCK (pedagogical content knowledge) of teachers who teach science content utilizing an integrated approach. The data has been collected by using CoRe, PaP-eR, and interviews from six elementary teachers who teach science. The paper informs that high and stable teacher PCKs have an impact on how teachers present integrated teaching. Because it is influenced by the selection of important content that must be submitted to the students, the depth of the content, the reasons for choosing the teaching procedures and some other things. So for teachers to be able to integrate teaching, they should have a balanced PCK.

  5. 1 Reevaluation of the integrated horizontal flux approach

    Science.gov (United States)

    Neftel, Albrecht; Häni, Christoph; Hensen, Arjan

    2017-04-01

    The integrated horizontal flux (IHF) method is a simplified mass balance approach frequently used to determine emissions from confined source areas, e.g. NH3 emissions from slurry spread to a circular plot (Denmead, 2008). With a mast in the center of the circle with radius R, the total flux F of the upwind emitted NH3 is approximated from the measured vertical (z) profiles of concentration (c) and horizontal wind speed (u) as (Denmead 1983): F = 1/R\\intz=zplz=0\\overline{u(c - cbgd)}dz where cbgd is the ``background'' concentration upwind of the emitting area and zpl is the maximum height of the emission plume (where the concentration c equals cbgd).The IHF method is a robust approach, as it is independent of surface characteristics and the state of atmospheric diffusion (Denmead, 2008; Laubach,2010). Ryden and McNeill (1984) published guidelines on how to evaluate IHF measurements, which have been used in many investigations that followed. In the following we analyze systematic biases that might occur by applying different recipes to both modelled concentration profiles as well as measured profiles from a recent field experiment in the Netherlands. Typical differencs using the approach by Ryden et al. (1984) are in the order +10% to +30% compared to the reference values from the model or alternative determination of the emissions based on the experimental values. The positive biases consist of several contributions: horizontal diffusion, logarithmic fit of the concentration profile, displacement height. References Denmead, O. T., 1983. Micrometeorological methods for measuring gaseous losses of nitrogen in the field. In: Gaseous Loss of Nitrogen from Plum-Soil Systems (Freney, J. R.; Simpson, J. R., Eds) Martinus Nijhof/Dr W. Junk, The Hague, pp. 133-157. Denmead, O. T., 2008. Approaches to measuring fluxes of methane and nitrous oxide between landscapes and the atmosphere. Plant Soil 309 (1-2), 5a\\euro 24.Laubach, J., 2010. Testing of a lagrangian model of

  6. An Integrated Approach for Physical and Cyber Security Risk Assessment: The U.S. Army Corps of Engineers Common Risk Model for Dams

    Science.gov (United States)

    2016-07-01

    colleagues from the U.S. Department of Homeland Security, in particular Dr. Enrique E. Matheu, Office of Infrastructure Protection, Sector Outreach and...Assessment: The U.S. Army Corps of Engineers Common Risk Model for Dams HQ0034-14-D-0001 5 b . GR A N T N O. 5 c . P R O G R AM E LE M E N T

  7. Die Konstruktion eines berufsbezogenen Persönlichkeitsfragebogens : Integration von Interpersonalem Circumplex, Fünf-Faktoren-Modell und Act Frequency Approach

    OpenAIRE

    Muck, Peter M.; Höft, Stefan; Hell, Benedikt; Schuler, Heinz

    2006-01-01

    In der vorliegenden Studie wird die Konstruktion eines Fragebogens zur Erfassung von interpersonalen Persönlichkeitseigenschaften mittels berufsbezogener Verhaltensweisen auf der Grundlage des Interpersonalen Circumplexes dargestellt. Der Interpersonale Circumplex (IPC) gilt als adäquates Modell zur Abbildung von Persönlichkeitseigenschaften, die sich auf zwischenmenschliches Verhalten beziehen. Bisher wurde der IPC zwar in verschiedenen Anwendungsfeldern untersucht, aber noch nicht in den or...

  8. Integrated Models of School-Based Prevention: Logic and Theory

    Science.gov (United States)

    Domitrovich, Celene E.; Bradshaw, Catherine P.; Greenberg, Mark T.; Embry, Dennis; Poduska, Jeanne M.; Ialongo, Nicholas S.

    2010-01-01

    School-based prevention programs can positively impact a range of social, emotional, and behavioral outcomes. Yet the current climate of accountability pressures schools to restrict activities that are not perceived as part of the core curriculum. Building on models from public health and prevention science, we describe an integrated approach to…

  9. A Graph Based Framework to Model Virus Integration Sites

    Directory of Open Access Journals (Sweden)

    Raffaele Fronza

    2016-01-01

    Here, we addressed the challenge to: 1 define the notion of CIS on graph models, 2 demonstrate that the structure of CIS enters in the category of scale-free networks and 3 show that our network approach analyzes CIS dynamically in an integrated systems biology framework using the Retroviral Transposon Tagged Cancer Gene Database (RTCGD as a testing dataset.

  10. Integrated landscape/hydrologic modeling tool for semiarid watersheds

    Science.gov (United States)

    Mariano Hernandez; Scott N. Miller

    2000-01-01

    An integrated hydrologic modeling/watershed assessment tool is being developed to aid in determining the susceptibility of semiarid landscapes to natural and human-induced changes across a range of scales. Watershed processes are by definition spatially distributed and are highly variable through time, and this approach is designed to account for their spatial and...

  11. Integrated climate and hydrology modelling

    DEFF Research Database (Denmark)

    Larsen, Morten Andreas Dahl

    global warming and increased frequency of extreme events. The skill in developing projections of both the present and future climate depends essentially on the ability to numerically simulate the processes of atmospheric circulation, hydrology, energy and ecology. Previous modelling efforts of climate......To ensure optimal management and sustainable strategies for water resources, infrastructures, food production and ecosystems there is a need for an improved understanding of feedback and interaction mechanisms between the atmosphere and the land surface. This is especially true in light of expected...... and hydrology models to more directly include the interaction between the atmosphere and the land surface. The present PhD study is motivated by an ambition of developing and applying a modelling tool capable of including the interaction and feedback mechanisms between the atmosphere and the land surface...

  12. HEDR modeling approach: Revision 1

    International Nuclear Information System (INIS)

    Shipler, D.B.; Napier, B.A.

    1994-05-01

    This report is a revision of the previous Hanford Environmental Dose Reconstruction (HEDR) Project modeling approach report. This revised report describes the methods used in performing scoping studies and estimating final radiation doses to real and representative individuals who lived in the vicinity of the Hanford Site. The scoping studies and dose estimates pertain to various environmental pathways during various periods of time. The original report discussed the concepts under consideration in 1991. The methods for estimating dose have been refined as understanding of existing data, the scope of pathways, and the magnitudes of dose estimates were evaluated through scoping studies

  13. HEDR modeling approach: Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Shipler, D.B.; Napier, B.A.

    1994-05-01

    This report is a revision of the previous Hanford Environmental Dose Reconstruction (HEDR) Project modeling approach report. This revised report describes the methods used in performing scoping studies and estimating final radiation doses to real and representative individuals who lived in the vicinity of the Hanford Site. The scoping studies and dose estimates pertain to various environmental pathways during various periods of time. The original report discussed the concepts under consideration in 1991. The methods for estimating dose have been refined as understanding of existing data, the scope of pathways, and the magnitudes of dose estimates were evaluated through scoping studies.

  14. Evolutionary algorithms approach for integrated bioenergy supply chains optimization

    International Nuclear Information System (INIS)

    Ayoub, Nasser; Elmoshi, Elsayed; Seki, Hiroya; Naka, Yuji

    2009-01-01

    In this paper, we propose an optimization model and solution approach for designing and evaluating integrated system of bioenergy production supply chains, SC, at the local level. Designing SC that simultaneously utilize a set of bio-resources together is a complicated task, considered here. The complication arises from the different nature and sources of bio-resources used in bioenergy production i.e., wet, dry or agriculture, industrial etc. Moreover, the different concerns that decision makers should take into account, to overcome the tradeoff anxieties of the socialists and investors, i.e., social, environmental and economical factors, was considered through the options of multi-criteria optimization. A first part of this research was introduced in earlier research work explaining the general Bioenergy Decision System gBEDS [Ayoub N, Martins R, Wang K, Seki H, Naka Y. Two levels decision system for efficient planning and implementation of bioenergy production. Energy Convers Manage 2007;48:709-23]. In this paper, brief introduction and emphasize on gBEDS are given; the optimization model is presented and followed by a case study on designing a supply chain of nine bio-resources at Iida city in the middle part of Japan.

  15. An integrated and pragmatic approach: Global plant safety management

    Science.gov (United States)

    McNutt, Jack; Gross, Andrew

    1989-05-01

    The Bhopal disaster in India in 1984 has compelled manufacturing companies to review their operations in order to minimize their risk exposure. Much study has been done on the subject of risk assessment and in refining safety reviews of plant operations. However, little work has been done to address the broader needs of decision makers in the multinational environment. The corporate headquarters of multinational organizations are concerned with identifying vulnerable areas to assure that appropriate risk-minimization measures are in force or will be taken. But the task of screening global business units for safety prowess is complicated and time consuming. This article takes a step towards simplifying this process by presenting the decisional model developed by the authors. Beginning with an overview of key issues affecting global safety management, the focus shifts to the multinational vulnerability model developed by the authors, which reflects an integration of approaches. The article concludes with a discussion of areas for further research. While the global chemical industry and major incidents therein are used for illustration, the procedures and solutions suggested here are applicable to all manufacturing operations.

  16. An Integrated Approach for Entry Mission Design and Flight Simulations

    Science.gov (United States)

    Lu, Ping; Rao, Prabhakara

    2004-01-01

    An integrated approach for entry trajectory design, guidance, and simulation is proposed. The key ingredients for this approach are an on-line 3 degree-of-freedom entry trajectory planning algorithm and the entry guidance algorithm that generates the guidance gains automatically. When fully developed, such a tool could enable end-bend entry mission design and simulations in 3DOF and 6DOF mode from de-orbit burn to the TAEM interface and beyond, all in one key stroke. Some preliminary examples of such a capability are presented in this paper that demonstrate the potential of this type of integrated environment.

  17. Ontology modeling in physical asset integrity management

    CERN Document Server

    Yacout, Soumaya

    2015-01-01

    This book presents cutting-edge applications of, and up-to-date research on, ontology engineering techniques in the physical asset integrity domain. Though a survey of state-of-the-art theory and methods on ontology engineering, the authors emphasize essential topics including data integration modeling, knowledge representation, and semantic interpretation. The book also reflects novel topics dealing with the advanced problems of physical asset integrity applications such as heterogeneity, data inconsistency, and interoperability existing in design and utilization. With a distinctive focus on applications relevant in heavy industry, Ontology Modeling in Physical Asset Integrity Management is ideal for practicing industrial and mechanical engineers working in the field, as well as researchers and graduate concerned with ontology engineering in physical systems life cycles. This book also: Introduces practicing engineers, research scientists, and graduate students to ontology engineering as a modeling techniqu...

  18. An Integrated Approach for Creating Service-Based Interactive Applications

    Science.gov (United States)

    Feldmann, Marius; Janeiro, Jordan; Nestler, Tobias; Hübsch, Gerald; Jugel, Uwe; Preussner, André; Schill, Alexander

    While the implementation of business logic and business processes based on service-oriented architectures is well-understood and covered by existing development approaches, integrated concepts that empower users to exploit the Internet of Services to create complex interactive applications are missing. In this paper, we present an integrated approach that fills this gap. Our approach builds upon service annotations that add meta-information related to user interface generation, service dependencies, and service composition to existing service descriptions. Services can be composed visually to complex interactive applications based on these annotations without the need to write any code. The application code is generated completely from the service composition description. Our approach is able to support heterogeneous target environments ranging from client/server architectures to mobile platforms.

  19. An integrated development environment for PMESII model authoring, integration, validation, and debugging

    Science.gov (United States)

    Pioch, Nicholas J.; Lofdahl, Corey; Sao Pedro, Michael; Krikeles, Basil; Morley, Liam

    2007-04-01

    To foster shared battlespace awareness in Air Operations Centers supporting the Joint Forces Commander and Joint Force Air Component Commander, BAE Systems is developing a Commander's Model Integration and Simulation Toolkit (CMIST), an Integrated Development Environment (IDE) for model authoring, integration, validation, and debugging. CMIST is built on the versatile Eclipse framework, a widely used open development platform comprised of extensible frameworks that enable development of tools for building, deploying, and managing software. CMIST provides two distinct layers: 1) a Commander's IDE for supporting staff to author models spanning the Political, Military, Economic, Social, Infrastructure, Information (PMESII) taxonomy; integrate multiple native (third-party) models; validate model interfaces and outputs; and debug the integrated models via intuitive controls and time series visualization, and 2) a PMESII IDE for modeling and simulation developers to rapidly incorporate new native simulation tools and models to make them available for use in the Commander's IDE. The PMESII IDE provides shared ontologies and repositories for world state, modeling concepts, and native tool characterization. CMIST includes extensible libraries for 1) reusable data transforms for semantic alignment of native data with the shared ontology, and 2) interaction patterns to synchronize multiple native simulations with disparate modeling paradigms, such as continuous-time system dynamics, agent-based discrete event simulation, and aggregate solution methods such as Monte Carlo sampling over dynamic Bayesian networks. This paper describes the CMIST system architecture, our technical approach to addressing these semantic alignment and synchronization problems, and initial results from integrating Political-Military-Economic models of post-war Iraq spanning multiple modeling paradigms.

  20. Modeling Approaches in Planetary Seismology

    Science.gov (United States)

    Weber, Renee; Knapmeyer, Martin; Panning, Mark; Schmerr, Nick

    2014-01-01

    Of the many geophysical means that can be used to probe a planet's interior, seismology remains the most direct. Given that the seismic data gathered on the Moon over 40 years ago revolutionized our understanding of the Moon and are still being used today to produce new insight into the state of the lunar interior, it is no wonder that many future missions, both real and conceptual, plan to take seismometers to other planets. To best facilitate the return of high-quality data from these instruments, as well as to further our understanding of the dynamic processes that modify a planet's interior, various modeling approaches are used to quantify parameters such as the amount and distribution of seismicity, tidal deformation, and seismic structure on and of the terrestrial planets. In addition, recent advances in wavefield modeling have permitted a renewed look at seismic energy transmission and the effects of attenuation and scattering, as well as the presence and effect of a core, on recorded seismograms. In this chapter, we will review these approaches.