WorldWideScience

Sample records for modeling approach developed

  1. Model Oriented Approach for Industrial Software Development

    Directory of Open Access Journals (Sweden)

    P. D. Drobintsev

    2015-01-01

    Full Text Available The article considers the specifics of a model oriented approach to software development based on the usage of Model Driven Architecture (MDA, Model Driven Software Development (MDSD and Model Driven Development (MDD technologies. Benefits of this approach usage in the software development industry are described. The main emphasis is put on the system design, automated code generation for large systems, verification, proof of system properties and reduction of bug density. Drawbacks of the approach are also considered. The approach proposed in the article is specific for industrial software systems development. These systems are characterized by different levels of abstraction, which is used on modeling and code development phases. The approach allows to detail the model to the level of the system code, at the same time store the verified model semantics and provide the checking of the whole detailed model. Steps of translating abstract data structures (including transactions, signals and their parameters into data structures used in detailed system implementation are presented. Also the grammar of a language for specifying rules of abstract model data structures transformation into real system detailed data structures is described. The results of applying the proposed method in the industrial technology are shown.The article is published in the authors’ wording.

  2. Agribusiness model approach to territorial food development

    Directory of Open Access Journals (Sweden)

    Murcia Hector Horacio

    2011-04-01

    Full Text Available

    Several research efforts have coordinated the academic program of Agricultural Business Management from the University De La Salle (Bogota D.C., to the design and implementation of a sustainable agribusiness model applied to food development, with territorial projection. Rural development is considered as a process that aims to improve the current capacity and potential of the inhabitant of the sector, which refers not only to production levels and productivity of agricultural items. It takes into account the guidelines of the Organization of the United Nations “Millennium Development Goals” and considered the concept of sustainable food and agriculture development, including food security and nutrition in an integrated interdisciplinary context, with holistic and systemic dimension. Analysis is specified by a model with an emphasis on sustainable agribusiness production chains related to agricultural food items in a specific region. This model was correlated with farm (technical objectives, family (social purposes and community (collective orientations projects. Within this dimension are considered food development concepts and methodologies of Participatory Action Research (PAR. Finally, it addresses the need to link the results to low-income communities, within the concepts of the “new rurality”.

  3. Child human model development: a hybrid validation approach

    NARCIS (Netherlands)

    Forbes, P.A.; Rooij, L. van; Rodarius, C.; Crandall, J.

    2008-01-01

    The current study presents a development and validation approach of a child human body model that will help understand child impact injuries and improve the biofidelity of child anthropometric test devices. Due to the lack of fundamental child biomechanical data needed to fully develop such models a

  4. Child human model development: a hybrid validation approach

    NARCIS (Netherlands)

    Forbes, P.A.; Rooij, L. van; Rodarius, C.; Crandall, J.

    2008-01-01

    The current study presents a development and validation approach of a child human body model that will help understand child impact injuries and improve the biofidelity of child anthropometric test devices. Due to the lack of fundamental child biomechanical data needed to fully develop such models a

  5. A Constructive Neural-Network Approach to Modeling Psychological Development

    Science.gov (United States)

    Shultz, Thomas R.

    2012-01-01

    This article reviews a particular computational modeling approach to the study of psychological development--that of constructive neural networks. This approach is applied to a variety of developmental domains and issues, including Piagetian tasks, shift learning, language acquisition, number comparison, habituation of visual attention, concept…

  6. A Constructive Neural-Network Approach to Modeling Psychological Development

    Science.gov (United States)

    Shultz, Thomas R.

    2012-01-01

    This article reviews a particular computational modeling approach to the study of psychological development--that of constructive neural networks. This approach is applied to a variety of developmental domains and issues, including Piagetian tasks, shift learning, language acquisition, number comparison, habituation of visual attention, concept…

  7. Development of a computationally efficient urban modeling approach

    DEFF Research Database (Denmark)

    Wolfs, Vincent; Murla, Damian; Ntegeka, Victor;

    2016-01-01

    This paper presents a parsimonious and data-driven modelling approach to simulate urban floods. Flood levels simulated by detailed 1D-2D hydrodynamic models can be emulated using the presented conceptual modelling approach with a very short calculation time. In addition, the model detail can...... be adjust-ed, allowing the modeller to focus on flood-prone locations. This results in efficiently parameterized models that can be tailored to applications. The simulated flood levels are transformed into flood extent maps using a high resolution (0.5-meter) digital terrain model in GIS. To illustrate...... the developed methodology, a case study for the city of Ghent in Belgium is elaborated. The configured conceptual model mimics the flood levels of a detailed 1D-2D hydrodynamic InfoWorks ICM model accurately, while the calculation time is an order of magnitude of 106 times shorter than the original highly...

  8. GEOSPATIAL MODELLING APPROACH FOR 3D URBAN DENSIFICATION DEVELOPMENTS

    Directory of Open Access Journals (Sweden)

    O. Koziatek

    2016-06-01

    Full Text Available With growing populations, economic pressures, and the need for sustainable practices, many urban regions are rapidly densifying developments in the vertical built dimension with mid- and high-rise buildings. The location of these buildings can be projected based on key factors that are attractive to urban planners, developers, and potential buyers. Current research in this area includes various modelling approaches, such as cellular automata and agent-based modelling, but the results are mostly linked to raster grids as the smallest spatial units that operate in two spatial dimensions. Therefore, the objective of this research is to develop a geospatial model that operates on irregular spatial tessellations to model mid- and high-rise buildings in three spatial dimensions (3D. The proposed model is based on the integration of GIS, fuzzy multi-criteria evaluation (MCE, and 3D GIS-based procedural modelling. Part of the City of Surrey, within the Metro Vancouver Region, Canada, has been used to present the simulations of the generated 3D building objects. The proposed 3D modelling approach was developed using ESRI’s CityEngine software and the Computer Generated Architecture (CGA language.

  9. Geospatial Modelling Approach for 3d Urban Densification Developments

    Science.gov (United States)

    Koziatek, O.; Dragićević, S.; Li, S.

    2016-06-01

    With growing populations, economic pressures, and the need for sustainable practices, many urban regions are rapidly densifying developments in the vertical built dimension with mid- and high-rise buildings. The location of these buildings can be projected based on key factors that are attractive to urban planners, developers, and potential buyers. Current research in this area includes various modelling approaches, such as cellular automata and agent-based modelling, but the results are mostly linked to raster grids as the smallest spatial units that operate in two spatial dimensions. Therefore, the objective of this research is to develop a geospatial model that operates on irregular spatial tessellations to model mid- and high-rise buildings in three spatial dimensions (3D). The proposed model is based on the integration of GIS, fuzzy multi-criteria evaluation (MCE), and 3D GIS-based procedural modelling. Part of the City of Surrey, within the Metro Vancouver Region, Canada, has been used to present the simulations of the generated 3D building objects. The proposed 3D modelling approach was developed using ESRI's CityEngine software and the Computer Generated Architecture (CGA) language.

  10. Development of a computationally efficient urban modeling approach

    DEFF Research Database (Denmark)

    Wolfs, Vincent; Murla, Damian; Ntegeka, Victor

    2016-01-01

    This paper presents a parsimonious and data-driven modelling approach to simulate urban floods. Flood levels simulated by detailed 1D-2D hydrodynamic models can be emulated using the presented conceptual modelling approach with a very short calculation time. In addition, the model detail can be a...

  11. Teachers' Development Model to Authentic Assessment by Empowerment Evaluation Approach

    Science.gov (United States)

    Charoenchai, Charin; Phuseeorn, Songsak; Phengsawat, Waro

    2015-01-01

    The purposes of this study were 1) Study teachers authentic assessment, teachers comprehension of authentic assessment and teachers needs for authentic assessment development. 2) To create teachers development model. 3) Experiment of teachers development model. 4) Evaluate effectiveness of teachers development model. The research is divided into 4…

  12. THE FAIRSHARES MODEL: AN ETHICAL APPROACH TO SOCIAL ENTERPRISE DEVELOPMENT?

    Directory of Open Access Journals (Sweden)

    Rory James Ridley-Duff

    2015-07-01

    Full Text Available This paper is based on the keynote address to the 14th International Association of Public and Non-Profit Marketing (IAPNM conference. It explore the question "What impact do ethical values in the FairShares Model have on social entrepreneurial behaviour?" In the first part, three broad approaches to social enterprise are set out: co-operative and mutual enterprises (CMEs, social and responsible businesses (SRBs and charitable trading activities (CTAs. The ethics that guide each approach are examined to provide a conceptual framework for examining FairShares as a case study. In the second part, findings are scrutinised in terms of the ethical values and principles that are activated when FairShares is applied to practice. The paper contributes to knowledge by giving an example of the way OpenSource technology (Loomio has been used to translate 'espoused theories' into 'theories in use' to advance social enterprise development. The review of FairShares using the conceptual framework suggests there is a fourth approach based on multi-stakeholder co-operation to create 'associative democracy' in the workplace.

  13. THE FAIRSHARES MODEL: AN ETHICAL APPROACH TO SOCIAL ENTERPRISE DEVELOPMENT?

    OpenAIRE

    Ridley-Duff, R.

    2015-01-01

    This paper is based on the keynote address to the 14th International Association of Public and Non-Profit Marketing (IAPNM) conference. It explore the question "What impact do ethical values in the FairShares Model have on social entrepreneurial behaviour?" In the first part, three broad approaches to social enterprise are set out: co-operative and mutual enterprises (CMEs), social and responsible businesses (SRBs) and charitable trading activities (CTAs). The ethics that guide each approach ...

  14. Computational Models of Spreadsheet Development: Basis for Educational Approaches

    CERN Document Server

    Hodnigg, Karin; Mittermeir, Roland T

    2008-01-01

    Among the multiple causes of high error rates in spreadsheets, lack of proper training and of deep understanding of the computational model upon which spreadsheet computations rest might not be the least issue. The paper addresses this problem by presenting a didactical model focussing on cell interaction, thus exceeding the atomicity of cell computations. The approach is motivated by an investigation how different spreadsheet systems handle certain computational issues implied from moving cells, copy-paste operations, or recursion.

  15. Development of a computationally efficient urban flood modelling approach

    DEFF Research Database (Denmark)

    Wolfs, Vincent; Ntegeka, Victor; Murla, Damian

    the developed methodology, a case study for the city of Ghent in Belgium is elaborated. The configured conceptual model mimics the flood levels of a detailed 1D-2D hydrodynamic InfoWorks ICM model accurately, while the calculation time is an order of magnitude of 106 times shorter than the original highly...

  16. A Conceptual DFT Approach Towards Developing New QSTR Models

    CERN Document Server

    Chattaraj, P K; Giri, S; Mukherjee, S; Roy, D R; Subramanian, V; Van Damme, S

    2007-01-01

    Quantitative-structure-toxicity-relationship (QSTR) models are developed for predicting the toxicity (pIGC50) of 252 aliphatic compounds on Tetrahymena pyriformis. The single parameter models with a simple molecular descriptor, the number of atoms in the molecule, provide unbelievable results. Better QSTR models with two parameters result when global electrophilicity is used as the second descriptor. In order to tackle both charge- and frontier-controlled reactions the importance of the local electro (nucleo) philicities and atomic charges is also analyzed. Best possible three parameter QSTR models are prescribed.

  17. A participatory modelling approach to developing a numerical sediment dynamics model

    Science.gov (United States)

    Jones, Nicholas; McEwen, Lindsey; Parker, Chris; Staddon, Chad

    2016-04-01

    Fluvial geomorphology is recognised as an important consideration in policy and legislation in the management of river catchments. Despite this recognition, limited knowledge exchange occurs between scientific researchers and river management practitioners. An example of this can be found within the limited uptake of numerical models of sediment dynamics by river management practitioners in the United Kingdom. The uptake of these models amongst the applied community is important as they have the potential to articulate how, at the catchment-scale, the impacts of management strategies of land-use change affect sediment dynamics and resulting channel quality. This paper describes and evaluates a new approach which involves river management stakeholders in an iterative and reflexive participatory modelling process. The aim of this approach was to create an environment for knowledge exchange between the stakeholders and the research team in the process of co-constructing a model. This process adopted a multiple case study approach, involving four groups of river catchment stakeholders in the United Kingdom. These stakeholder groups were involved in several stages of the participatory modelling process including: requirements analysis, model design, model development, and model evaluation. Stakeholders have provided input into a number of aspects of the modelling process, such as: data requirements, user interface, modelled processes, model assumptions, model applications, and model outputs. This paper will reflect on this process, in particular: the innovative methods used, data generated, and lessons learnt.

  18. Development of a core-stability model: a delphi approach.

    Science.gov (United States)

    Majewski-Schrage, Tricia; Evans, Todd A; Ragan, Brian

    2014-05-01

    Despite widespread acceptance, there is currently no consensus on the definition, components, and the specific techniques most appropriate to measure and quantify core stability. To develop a comprehensive core-stability model addressing its definition, components, and assessment techniques. Delphi technique. University laboratory. 15 content experts from United States and Canada, representing a variety of disciplines. The authors distributed an open-ended questionnaire pertaining to a core-stability definition, components, and assessment techniques specific to each expert. They collected data over 2 rounds of telephone interviews. They concluded data collection once a consensus was achieved that equated with 51% agreement among respondents. The authors developed a working definition of core stability as the ability to achieve and sustain control of the trunk region at rest and during precise movement. Eighty-three percent of the experts considered the definition satisfactory. Therefore, the definition was accepted. Furthermore, the experts agreed that muscles (14/15 = 93.3%) and neuromuscular control (8/12 = 66.7%) were components of core stability. Assessment techniques were identified and inconsistencies were highlighted; however, no consensus was established. A consensus core-stability definition was created and 2 components were identified. However, of the initial definitions provided by the experts, no 2 were identical, which revealed the inconsistencies among experts and the importance of this study. Nonetheless, the goal of obtaining a consensus definition was obtained. Although a consensus for the assessment techniques of core stability could not be reached, it was a beneficial starting point to identify the inconsistencies that were discovered among the content experts.

  19. Developing a parameterization approach of soil erodibility for the Rangeland Hydrology and Erosion Model (RHEM)

    Science.gov (United States)

    Soil erodibility is a key factor for estimating soil erosion using physically based models. In this study, a new parameterization approach for estimating erodibility was developed for the Rangeland Hydrology and Erosion Model (RHEM). The approach uses empirical equations that were developed by apply...

  20. Measuring speech sound development : An item response model approach

    NARCIS (Netherlands)

    Priester, Gertrude H.; Goorhuis - Brouwer, Siena

    2013-01-01

    Research aim: The primary aim of our study is to investigate if there is an ordering in the speech sound development of children aged 3-6, similar to the ordering in general language development. Method: The speech sound development of 1035 children was tested with a revised version of Logo-Articula

  1. Model-Driven Approach for Body Area Network Application Development.

    Science.gov (United States)

    Venčkauskas, Algimantas; Štuikys, Vytautas; Jusas, Nerijus; Burbaitė, Renata

    2016-05-12

    This paper introduces the sensor-networked IoT model as a prototype to support the design of Body Area Network (BAN) applications for healthcare. Using the model, we analyze the synergistic effect of the functional requirements (data collection from the human body and transferring it to the top level) and non-functional requirements (trade-offs between energy-security-environmental factors, treated as Quality-of-Service (QoS)). We use feature models to represent the requirements at the earliest stage for the analysis and describe a model-driven methodology to design the possible BAN applications. Firstly, we specify the requirements as the problem domain (PD) variability model for the BAN applications. Next, we introduce the generative technology (meta-programming as the solution domain (SD)) and the mapping procedure to map the PD feature-based variability model onto the SD feature model. Finally, we create an executable meta-specification that represents the BAN functionality to describe the variability of the problem domain though transformations. The meta-specification (along with the meta-language processor) is a software generator for multiple BAN-oriented applications. We validate the methodology with experiments and a case study to generate a family of programs for the BAN sensor controllers. This enables to obtain the adequate measure of QoS efficiently through the interactive adjustment of the meta-parameter values and re-generation process for the concrete BAN application.

  2. Model-Driven Approach for Body Area Network Application Development

    Directory of Open Access Journals (Sweden)

    Algimantas Venčkauskas

    2016-05-01

    Full Text Available This paper introduces the sensor-networked IoT model as a prototype to support the design of Body Area Network (BAN applications for healthcare. Using the model, we analyze the synergistic effect of the functional requirements (data collection from the human body and transferring it to the top level and non-functional requirements (trade-offs between energy-security-environmental factors, treated as Quality-of-Service (QoS. We use feature models to represent the requirements at the earliest stage for the analysis and describe a model-driven methodology to design the possible BAN applications. Firstly, we specify the requirements as the problem domain (PD variability model for the BAN applications. Next, we introduce the generative technology (meta-programming as the solution domain (SD and the mapping procedure to map the PD feature-based variability model onto the SD feature model. Finally, we create an executable meta-specification that represents the BAN functionality to describe the variability of the problem domain though transformations. The meta-specification (along with the meta-language processor is a software generator for multiple BAN-oriented applications. We validate the methodology with experiments and a case study to generate a family of programs for the BAN sensor controllers. This enables to obtain the adequate measure of QoS efficiently through the interactive adjustment of the meta-parameter values and re-generation process for the concrete BAN application.

  3. Developing Intercultural Understanding and Skills: Models and Approaches

    Science.gov (United States)

    Perry, Laura B.; Southwell, Leonie

    2011-01-01

    Researchers from a range of disciplines have been theorising and empirically examining intercultural competence and intercultural education for decades. This review article synthesises the research literature about these concepts around three questions: What is intercultural competence? How can it be developed? And how can it be measured? Our aim…

  4. The Chain Information Model: a systematic approach for food product development

    NARCIS (Netherlands)

    Benner, M.

    2005-01-01

    The chain information model has been developed to increase the success rate of new food products. The uniqueness of this approach is that it approaches the problem from a chain perspective and starts with the consumer. The model can be used to analyse the production chain in a systematic way. This

  5. The Chain Information Model: a systematic approach for food product development

    NARCIS (Netherlands)

    Benner, M.

    2005-01-01

    The chain information model has been developed to increase the success rate of new food products. The uniqueness of this approach is that it approaches the problem from a chain perspective and starts with the consumer. The model can be used to analyse the production chain in a systematic way. This r

  6. Development of a Conservative Model Validation Approach for Reliable Analysis

    Science.gov (United States)

    2015-01-01

    optimization in Eq. (6) is [μθ, σθ]. The Young’s modulus is 200,000 lb/in2 and the applied pressure load is 20 lb/in2. The output g in Eq. (6) is the...with Cooperative Agreement W56HZV-04-2-0001 U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC). REFERENCES [1] Hills

  7. Development of Modeling Approaches for Nuclear Thermal Propulsion Test Facilities

    Science.gov (United States)

    Jones, Daniel R.; Allgood, Daniel C.; Nguyen, Ke

    2014-01-01

    High efficiency of rocket propul-sion systems is essential for humanity to venture be-yond the moon. Nuclear Thermal Propulsion (NTP) is a promising alternative to conventional chemical rock-ets with relatively high thrust and twice the efficiency of the Space Shuttle Main Engine. NASA is in the pro-cess of developing a new NTP engine, and is evaluat-ing ground test facility concepts that allow for the thor-ough testing of NTP devices. NTP engine exhaust, hot gaseous hydrogen, is nominally expected to be free of radioactive byproducts from the nuclear reactor; how-ever, it has the potential to be contaminated due to off-nominal engine reactor performance. Several options are being investigated to mitigate this hazard potential with one option in particular that completely contains the engine exhaust during engine test operations. The exhaust products are subsequently disposed of between engine tests. For this concept (see Figure 1), oxygen is injected into the high-temperature hydrogen exhaust that reacts to produce steam, excess oxygen and any trace amounts of radioactive noble gases released by off-nominal NTP engine reactor performance. Water is injected to condense the potentially contaminated steam into water. This water and the gaseous oxygen (GO2) are subsequently passed to a containment area where the water and GO2 are separated into separate containment tanks.

  8. Development of CFD Approaches for Modeling Advanced Concepts of Nuclear Thermal Propulsion Test Facilities Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The project will be developing a CFD approach that can handle the additional complexities needed in a NTP testing facility when modeling the combustion processes in...

  9. Stochastic Approach for Modeling of DNAPL Migration in Heterogeneous Aquifers: Model Development and Experimental Data Generation

    Science.gov (United States)

    Dean, D. W.; Illangasekare, T. H.; Turner, A.; Russell, T. F.

    2004-12-01

    Modeling of the complex behavior of DNAPLs in naturally heterogeneous subsurface formations poses many challenges. Even though considerable progress have been made in developing improved numerical schemes to solve the governing partial differential equations, most of these methods still rely on deterministic description of the processes. This research explores the use of stochastic differential equations to model multiphase flow in heterogeneous aquifers, specifically the flow of DNAPLs in saturated soils. The models developed are evaluated using experimental data generated in two-dimensional test systems. A fundamental assumption used in the model formulation is that the movement of a fluid particle in each phase is described by a stochastic process and that the positions of all fluid particles over time are governed by a specific law. It is this law, which we seek to determine. The approach results in a nonlinear stochastic differential equation describing the position of the non-wetting phase fluid particle. The nonlinearity in the stochastic differential equation arises because both the drift and diffusion coefficients depend on the volumetric fraction of the phase, which in turn depends on the position of the fluid particles in the problem domain. The concept of a fluid particle is central to the development of the proposed model. Expressions for both saturation and volumetric fraction are developed using this concept of fluid particle. Darcy's law and the continuity equation are used to derive a Fokker-Planck equation governing flow. The Ito calculus is then applied to derive a stochastic differential equation(SDE) for the non-wetting phase. This SDE has both drift and diffusion terms which depend on the volumetric fraction of the non-wetting phase. Standard stochastic theories based on the Ito calculus and the Wiener process and the equivalent Fokker-Planck PDE's are typically used to model diffusion processes. However, these models, in their usual form

  10. Research on the Development Approach for Reusable Model in Parallel Discrete Event Simulation

    Directory of Open Access Journals (Sweden)

    Jianbo Li

    2015-01-01

    Full Text Available Model reuse is an essential means to meet the demand of model development in complex simulation. An effective approach to realize the model reusability is to establish standard model specification including interface specification and representation specification. By standardizing model’s external interfaces, Reusable Component Model Framework (RCMF achieves the model reusability acting as an interface specification. However, the RCMF model is presently developed just through manual programing. Besides implementing model’s business logic, modeler should also ensure the model strictly following the reusable framework, which is very distracting. And there lacks model description information for instructing model reuse or integration. To address these issues, we first explored an XML-based model description file which completed RCMF as the model representation and then proposed a RCMF model development tool—SuKit. Model description file describes a RCMF model and can be used for regenerating a model and instructing model integration. SuKit can generate a skeleton RCMF model together with a model-customized description file with the configured information. Modeler then just needs to concentrate on the model processing logic. The case study indicates that SuKit has good capability of developing RCMF models and the well-formed description file can be used for model reuse and integration.

  11. Model-centric approaches for the development of health information systems.

    Science.gov (United States)

    Tuomainen, Mika; Mykkänen, Juha; Luostarinen, Heli; Pöyhölä, Assi; Paakkanen, Esa

    2007-01-01

    Modeling is used increasingly in healthcare to increase shared knowledge, to improve the processes, and to document the requirements of the solutions related to health information systems (HIS). There are numerous modeling approaches which aim to support these aims, but a careful assessment of their strengths, weaknesses and deficiencies is needed. In this paper, we compare three model-centric approaches in the context of HIS development: the Model-Driven Architecture, Business Process Modeling with BPMN and BPEL and the HL7 Development Framework. The comparison reveals that all these approaches are viable candidates for the development of HIS. However, they have distinct strengths and abstraction levels, they require local and project-specific adaptation and offer varying levels of automation. In addition, illustration of the solutions to the end users must be improved.

  12. GRAPH THEORETICAL AND NETWORKS APPROACH FOR THE DEVELOPMENT OF A LEARNING MODEL – A CASE STUDY

    Directory of Open Access Journals (Sweden)

    PROF. DR. P. K. SRIMANI

    2012-08-01

    Full Text Available This paper deals with the graph theoretical approach for developing a framework for the Learning model used to optimise the Mathematical Pathway in children at the elementary level and verifying it by usingNetworks model. Data collected pertaining to the mathematical concepts a child needs to learn at elementary level [Class I to VII] is represented by using Concept Flow Graphs and are optimized by using graph theory techniques and algorithms by rearranging nodes as per the learning progression, partitioning the graphs into subgraphsto represent levels of learning, optimizing the sub-graphs using merging and elimination technique and identifying / marking the optional nodes. The design of the framework by using the graph theoretical approach is validated by the application of the Networks approach and this is used to design the Mathematical Pathwaydriver which is the core component of the Learning model. This approach is novel and the Learning model developed is highly accurate.

  13. Developing population models: A systematic approach for pesticide risk assessment using herbaceous plants as an example.

    Science.gov (United States)

    Schmolke, Amelie; Kapo, Katherine E; Rueda-Cediel, Pamela; Thorbek, Pernille; Brain, Richard; Forbes, Valery

    2017-12-01

    Population models are used as tools in species management and conservation and are increasingly recognized as important tools in pesticide risk assessments. A wide variety of population model applications and resources on modeling techniques, evaluation and documentation can be found in the literature. In this paper, we add to these resources by introducing a systematic, transparent approach to developing population models. The decision guide that we propose is intended to help model developers systematically address data availability for their purpose and the steps that need to be taken in any model development. The resulting conceptual model includes the necessary complexity to address the model purpose on the basis of current understanding and available data. We provide specific guidance for the development of population models for herbaceous plant species in pesticide risk assessment and demonstrate the approach with an example of a conceptual model developed following the decision guide for herbicide risk assessment of Mead's milkweed (Asclepias meadii), a species listed as threatened under the US Endangered Species Act. The decision guide specific to herbaceous plants demonstrates the details, but the general approach can be adapted for other species groups and management objectives. Population models provide a tool to link population-level dynamics, species and habitat characteristics as well as information about stressors in a single approach. Developing such models in a systematic, transparent way will increase their applicability and credibility, reduce development efforts, and result in models that are readily available for use in species management and risk assessments. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Using the Outcome-Driven Innovation Approach to Develop a Customer Value Model for Lighting

    OpenAIRE

    Dalton, Nonie

    2012-01-01

    LED technology is on the cusp of disrupting the entire lighting industry if the industry can develop new lighting products that customers will want to use and purchase. Understanding what customers value from their lighting products is an open question for the industry. To answer this question and to provide a deeper understanding of customer’s needs, I have applied the outcome driven innovation approach. Through this approach the customer value model was developed, which identifies customers...

  15. Development of a New Approach to Instrument Model Design Used by Team X

    Science.gov (United States)

    Andrew, Shanna E.

    2005-01-01

    The Jet Propulsion Laboratory's Advanced Design Team was formed in April 1995 to improve the quality and reduce the cost of JPL proposals and advanced mission studies. Currently a consolidation attempt is underway to develop a Model Library for use by JPL's Advanced Projects Design Team by collecting existing instrument models for inclusion in the library. This will allow users to readily find models of interest. In addition to this, there is also an attempt underway to develop a new approach to instrument model design used by the Advanced Design Team (Team X). This new approach consists of splitting up the different model parts such as orbital parameters, instrument parameters and instrument outputs into separate searchable parts. The user can then decide between design trades and use the different pieces to construct a model that will fit their needs. As well, this will lead to the opportunity for the large variety of usable instrument models.

  16. A Role-Based Approach to Adult Development: The Triple-Helix Model.

    Science.gov (United States)

    Juhasz, Anne McCreary

    1989-01-01

    Presents triple-helix model of adult development which incorporates three major roles: family, work, and self, each powered by drive for self-esteem. Asserts that this approach accommodates wide range of possible patterns and varied timing of life events relative to career options, family and relationship choices, and emphasis on self-development.…

  17. A Domain-specific Modeling Approach to the Development of Online Peer Assessment

    NARCIS (Netherlands)

    Miao, Yongwu; Koper, Rob

    2007-01-01

    Miao, Y., & Koper, R. (2007). A Domain-specific Modeling Approach to the Development of Online Peer Assessment. In T. Navarette, J. Blat & R. Koper (Eds.). Proceedings of the 3rd TENCompetence Open Workshop 'Current Research on IMS Learning Design and Lifelong Competence Development Infrastructures'

  18. Comparison of the Two-Hemisphere Model-Driven Approach to Other Methods for Model-Driven Software Development

    Directory of Open Access Journals (Sweden)

    Nikiforova Oksana

    2015-12-01

    Full Text Available Models are widely used not only in computer science field, but also in other fields. They are an effective way to show relevant information in a convenient way. Model-driven software development uses models and transformations as first-class citizens. That makes software development phases more related to each other, those links later help to make changes or modify software product more freely. At the moment there are a lot of methods and techniques to create those models and transform them into each other. Since 2004, authors have been developing the so called 2HMD approach to bridge the gap between problem domain and software components by using models and model transformation. The goal of this research is to compare different methods positioned for performing the same tasks as the 2HMD approach and to understand the state of the art in the area of model-driven software development.

  19. The use of CORE model by metacognitive skill approach in developing characters junior high school students

    Science.gov (United States)

    Fisher, Dahlia; Yaniawati, Poppy; Kusumah, Yaya Sukjaya

    2017-08-01

    This study aims to analyze the character of students who obtain CORE learning model using metacognitive approach. The method in this study is qualitative research and quantitative research design (Mixed Method Design) with concurrent embedded strategy. The research was conducted on two groups: an experimental group and the control group. An experimental group consists of students who had CORE model learning using metacognitive approach while the control group consists of students taught by conventional learning. The study was conducted the object this research is the seventh grader students in one the public junior high schools in Bandung. Based on this research, it is known that the characters of the students in the CORE model learning through metacognitive approach is: honest, hard work, curious, conscientious, creative and communicative. Overall it can be concluded that CORE model learning is good for developing characters of a junior high school student.

  20. Spatial Modelling of Urban Growth and Urban Influence: Approach of Regional Development in Developing Economy (India

    Directory of Open Access Journals (Sweden)

    Md. Julfikar ALI

    2012-12-01

    Full Text Available Urbanization and regional development are closely associated. Allocation of higher and lower order facilities and specialization of business influence urban growth which diffuses its benefits to the surrounding countryside. Subsequently, socio-economic development of the region comes into being. The continuous increase of urban size can not be sustained rather declining growth will certainly set in long run. Optimum level of its growth depends on the capacity of an urban centre to provide required facilities to the people in fair manner. Hierarchical growth of urban centres in association with location of civic amenities induces regional development in hierarchical dimension which is the common problem in developing economy. Subsequently, few of the urban centres are having large number of facilities while others are lacking corresponding to their population size. Formulation of pragmatic planning model is the rescue of wiping out such problems. It is an attempt to analyze the hierarchical growth of urban centres associated with their functional potentiality and diffusion of urban developmental impulses to the surrounding rural part. Further, it proposes a model for developing economy like India to solve the problem of regional variations of development. Besides, it examines the adequacy and inadequacy of facilities in the urban centres and puts forward planning recommendations, so that a balanced regional development would be achieved by not leaving any rural part out of the zone of functional influence of urban centre.

  1. Towards a model-based development approach for wireless sensor-actuator network protocols

    DEFF Research Database (Denmark)

    Kumar S., A. Ajith; Simonsen, Kent Inge

    2014-01-01

    Model-Driven Software Engineering (MDSE) is a promising approach for the development of applications, and has been well adopted in the embedded applications domain in recent years. Wireless Sensor Actuator Networks consisting of resource constrained hardware and platformspecific operating system...

  2. Combining engineering and data-driven approaches: Development of a generic fire risk model facilitating calibration

    DEFF Research Database (Denmark)

    De Sanctis, G.; Fischer, K.; Kohler, J.

    2014-01-01

    Fire risk models support decision making for engineering problems under the consistent consideration of the associated uncertainties. Empirical approaches can be used for cost-benefit studies when enough data about the decision problem are available. But often the empirical approaches...... a generic risk model that is calibrated to observed fire loss data. Generic risk models assess the risk of buildings based on specific risk indicators and support risk assessment at a portfolio level. After an introduction to the principles of generic risk assessment, the focus of the present paper...... are not detailed enough. Engineering risk models, on the other hand, may be detailed but typically involve assumptions that may result in a biased risk assessment and make a cost-benefit study problematic. In two related papers it is shown how engineering and data-driven modeling can be combined by developing...

  3. The Models of Relationship between Training and Psyche development in Cultural-historical and Activity Approaches

    Directory of Open Access Journals (Sweden)

    Pogozhina I.N.,

    2016-12-01

    Full Text Available The possibility of referring of the psychological theories studying interrelation of training and mental development processes to this or that stage of scientific knowledge formation on the basis of studied objects types and corresponded determination systems as a basic criterion distinguishing the ideals of scientific rationality is justified. General characteristics of classical, non-classical and post-non-classical models, determination of the mechanisms of dissipative systems, requirements for learning and development model building in the context of post-non-classic science paradigm on the criterion of the system features of the object of cognition are described. Domestic psychological school models are compared with associanism, behaviorism, gestalt psychology and Piaget determination models on the number of options allocated to these determinants, types of causal chains and types of links between causal chains. It is shown that cultural-historical approach is situated intermediately between post-non-classical and non-classical models, while activity approach corresponds to post-non-classical understanding of the object of study as complicated self-developing "man-size" system. Determination relationships models developed by L.V.Vygotskii, S.L. Rubinstein, A.N. Leont’ev continue to play the heuristic role at the present stage of scientific development.

  4. Approach and development strategy for an agent-based model of economic confidence.

    Energy Technology Data Exchange (ETDEWEB)

    Sprigg, James A.; Pryor, Richard J.; Jorgensen, Craig Reed

    2004-08-01

    We are extending the existing features of Aspen, a powerful economic modeling tool, and introducing new features to simulate the role of confidence in economic activity. The new model is built from a collection of autonomous agents that represent households, firms, and other relevant entities like financial exchanges and governmental authorities. We simultaneously model several interrelated markets, including those for labor, products, stocks, and bonds. We also model economic tradeoffs, such as decisions of households and firms regarding spending, savings, and investment. In this paper, we review some of the basic principles and model components and describe our approach and development strategy for emulating consumer, investor, and business confidence. The model of confidence is explored within the context of economic disruptions, such as those resulting from disasters or terrorist events.

  5. Developing scenarios to assess future landslide risks: a model-based approach applied to mountainous regions

    Science.gov (United States)

    Vacquie, Laure; Houet, Thomas

    2016-04-01

    In the last century, European mountain landscapes have experienced significant transformations. Natural and anthropogenic changes, climate changes, touristic and industrial development, socio-economic interactions, and their implications in terms of LUCC (land use and land cover changes) have directly influenced the spatial organization and vulnerability of mountain landscapes. This study is conducted as part of the SAMCO project founded by the French National Science Agency (ANR). It aims at developing a methodological approach, combining various tools, modelling platforms and methods, to identify vulnerable regions to landslide hazards accounting for futures LUCC. It presents an integrated approach combining participative scenarios and a LULC changes simulation models to assess the combined effects of LUCC and climate change on landslide risks in the Cauterets valley (French Pyrenees Mountains) up to 2100. Through vulnerability and risk mapping, the objective is to gather information to support landscape planning and implement land use strategies with local stakeholders for risk management. Four contrasting scenarios are developed and exhibit contrasting trajectories of socio-economic development. Prospective scenarios are based on national and international socio-economic contexts relying on existing assessment reports. The methodological approach integrates knowledge from local stakeholders to refine each scenario during their construction and to reinforce their plausibility and relevance by accounting for local specificities, e.g. logging and pastoral activities, touristic development, urban planning, etc. A process-based model, the Forecasting Scenarios for Mountains (ForeSceM) model, developed on the Dinamica Ego modelling platform is used to spatially allocate futures LUCC for each prospective scenario. Concurrently, a spatial decision support tool, i.e. the SYLVACCESS model, is used to identify accessible areas for forestry in scenario projecting logging

  6. A Model-Driven Engineering Approach to Develop a Cooperative Information System

    Directory of Open Access Journals (Sweden)

    Jean Michel Inglebert

    2013-06-01

    Full Text Available To reuse one or several existing systems in orderto develop a complex system isa common practice insoftware engineering. This approach can be justified by thefact that it is often difficult for a singleInformation System(IS to accomplish all the requested tasks. So, one solution isto combine many differentISs and make them collaboratein order to realize these tasks. We proposed anapproach named AspeCiS(An Aspect-oriented Approach toDevelop a Cooperative Information System to develop aCooperativeInformation System from existing ISs by usingtheir artifacts such as existing requirements, and design.AspeCiS covers the three following phases: (i discoveryand analysis of Cooperative Requirements, (iidesign ofCooperative Requirements models, and (iii preparation ofthe implementation phase. The mainissue of AspeCiS is thedefinition of Cooperative Requirements using the ExistingRequirements andAdditional Requirements, which shouldbe composed with Aspectual Requirements. We earlier studiedhowto elicit the Cooperative Requirements in AspeCiS(phase ofdiscoveryand analysis of CooperativeRequirementsin AspeCiS.We studyherethe second phase of AspeCiS(design ofCooperativeRequirements models, by the way of a model weavingprocess. This process uses so-called AspeCiSWeaving Metamodel, and it weaves Existing andAdditional Requirementsmodels to realize CooperativeRequirements models

  7. Developing approaches for linear mixed modeling in landscape genetics through landscape-directed dispersal simulations

    Science.gov (United States)

    Row, Jeffrey R.; Knick, Steven T.; Oyler-McCance, Sara J.; Lougheed, Stephen C.; Fedy, Bradley C.

    2017-01-01

    Dispersal can impact population dynamics and geographic variation, and thus, genetic approaches that can establish which landscape factors influence population connectivity have ecological and evolutionary importance. Mixed models that account for the error structure of pairwise datasets are increasingly used to compare models relating genetic differentiation to pairwise measures of landscape resistance. A model selection framework based on information criteria metrics or explained variance may help disentangle the ecological and landscape factors influencing genetic structure, yet there are currently no consensus for the best protocols. Here, we develop landscape-directed simulations and test a series of replicates that emulate independent empirical datasets of two species with different life history characteristics (greater sage-grouse; eastern foxsnake). We determined that in our simulated scenarios, AIC and BIC were the best model selection indices and that marginal R2 values were biased toward more complex models. The model coefficients for landscape variables generally reflected the underlying dispersal model with confidence intervals that did not overlap with zero across the entire model set. When we controlled for geographic distance, variables not in the underlying dispersal models (i.e., nontrue) typically overlapped zero. Our study helps establish methods for using linear mixed models to identify the features underlying patterns of dispersal across a variety of landscapes.

  8. Developing approaches for linear mixed modeling in landscape genetics through landscape-directed dispersal simulations.

    Science.gov (United States)

    Row, Jeffrey R; Knick, Steven T; Oyler-McCance, Sara J; Lougheed, Stephen C; Fedy, Bradley C

    2017-06-01

    Dispersal can impact population dynamics and geographic variation, and thus, genetic approaches that can establish which landscape factors influence population connectivity have ecological and evolutionary importance. Mixed models that account for the error structure of pairwise datasets are increasingly used to compare models relating genetic differentiation to pairwise measures of landscape resistance. A model selection framework based on information criteria metrics or explained variance may help disentangle the ecological and landscape factors influencing genetic structure, yet there are currently no consensus for the best protocols. Here, we develop landscape-directed simulations and test a series of replicates that emulate independent empirical datasets of two species with different life history characteristics (greater sage-grouse; eastern foxsnake). We determined that in our simulated scenarios, AIC and BIC were the best model selection indices and that marginal R(2) values were biased toward more complex models. The model coefficients for landscape variables generally reflected the underlying dispersal model with confidence intervals that did not overlap with zero across the entire model set. When we controlled for geographic distance, variables not in the underlying dispersal models (i.e., nontrue) typically overlapped zero. Our study helps establish methods for using linear mixed models to identify the features underlying patterns of dispersal across a variety of landscapes.

  9. How structure shapes dynamics: knowledge development in Wikipedia--a network multilevel modeling approach.

    Directory of Open Access Journals (Sweden)

    Iassen Halatchliyski

    Full Text Available Using a longitudinal network analysis approach, we investigate the structural development of the knowledge base of Wikipedia in order to explain the appearance of new knowledge. The data consists of the articles in two adjacent knowledge domains: psychology and education. We analyze the development of networks of knowledge consisting of interlinked articles at seven snapshots from 2006 to 2012 with an interval of one year between them. Longitudinal data on the topological position of each article in the networks is used to model the appearance of new knowledge over time. Thus, the structural dimension of knowledge is related to its dynamics. Using multilevel modeling as well as eigenvector and betweenness measures, we explain the significance of pivotal articles that are either central within one of the knowledge domains or boundary-crossing between the two domains at a given point in time for the future development of new knowledge in the knowledge base.

  10. Kind discipline: Developing a conceptual model of a promising school discipline approach.

    Science.gov (United States)

    Winkler, Jennifer L; Walsh, Michele E; de Blois, Madeleine; Maré, Jeannette; Carvajal, Scott C

    2017-02-06

    This formative evaluation develops a novel conceptual model for a discipline approach fostering intrinsic motivation and positive relationships in schools. We used concept mapping to elicit and integrate perspectives on kind discipline from teachers, administrators, and other school staff. Three core themes describing kind discipline emerged from 11 identified clusters: (1) proactively developing a positive school climate, (2) responding to conflict with empathy, accountability, and skill, and (3) supporting staff skills in understanding and sharing expectations. We mapped the identified components of kind discipline onto a social ecological model and found that kind discipline encompasses all levels of that model including the individual, relational, environmental/structural, and even community levels. This contrasts with the dominant individual-behavioral discipline approaches that focus on fewer levels and may not lead to sustained student and staff motivation. The findings illustrate the importance of setting and communicating clear expectations and the need for them to be collaboratively developed. Products of the analysis and synthesis reported here are operationalized materials for teachers grounded in a "be kind" culture code for classrooms.

  11. Evaluating the Mental Models Approach to Developing a Risk Communication: A Scoping Review of the Evidence.

    Science.gov (United States)

    Boase, Nick; White, Mathew; Gaze, William; Redshaw, Clare

    2017-03-17

    Risk communication is fundamental in ensuring people are equipped with the knowledge needed to navigate varied risks. One generally well-regarded framework for the development of such communications is the mental models approach to risk communication (MMARC). Developed during the 1990s, the MMARC has been applied to a range of health, technological, and environmental risks. However, as yet, we know of no attempt to collate and review articles that evaluated communications developed using the MMARC. This article took a first step at addressing this gap by conducting a scoping review that aimed to begin to explore the fidelity with which the approach has been applied, explore whether there appeared to be sufficient studies to warrant a future systematic review, and identify future research questions. Although the initial search found over 100 articles explicitly applying the MMARC, only 12 of these developed a risk-related communication that was tested against a control (and thus included in the current review). All studies reported a positive effect of the MMARC versus control communication for at least some of the outcome measures (knowledge being the most prevalent). However, there was wide variation between studies including type of control, outcomes assessed, and only five studies reported adopting a randomized design. The review highlights both the need for greater fidelity in the way future studies operationalize the MMARC approach, and suggests that a full-scale systematic review of the MMARC literature appears justified, especially given the possibility of a large gray literature in this area.

  12. DEVELOPMENT OF A GIS DATA MODEL WITH SPATIAL,TEMPORAL AND ATTRIBUTE COMPONENTS BASED ON OBJECT-ORIENTED APPROACH

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper presents a conceptual data model, the STA-model, for handling spatial, temporal and attribute aspects of objects in GIS. The model is developed on the basis of object-oriented modeling approach. This model includes two major parts: (a) modeling the signal objects by STA-object elements, and (b) modeling relationships between STA-objects. As an example, the STA-model is applied for modeling land cover change data with spatial, temporal and attribute components.

  13. A systematic approach for scale-down model development and characterization of commercial cell culture processes.

    Science.gov (United States)

    Li, Feng; Hashimura, Yasunori; Pendleton, Robert; Harms, Jean; Collins, Erin; Lee, Brian

    2006-01-01

    The objective of process characterization is to demonstrate robustness of manufacturing processes by understanding the relationship between key operating parameters and final performance. Technical information from the characterization study is important for subsequent process validation, and this has become a regulatory expectation in recent years. Since performing the study at the manufacturing scale is not practically feasible, development of scale-down models that represent the performance of the commercial process is essential to achieve reliable process characterization. In this study, we describe a systematic approach to develop a bioreactor scale-down model and to characterize a cell culture process for recombinant protein production in CHO cells. First, a scale-down model using 2-L bioreactors was developed on the basis of the 2000-L commercial scale process. Profiles of cell growth, productivity, product quality, culture environments (pH, DO, pCO2), and level of metabolites (glucose, glutamine, lactate, ammonia) were compared between the two scales to qualify the scale-down model. The key operating parameters were then characterized in single-parameter ranging studies and an interaction study using this scale-down model. Appropriate operation ranges and acceptance criteria for certain key parameters were determined to ensure the success of process validation and the process performance consistency. The process worst-case condition was also identified through the interaction study.

  14. Analysis of enamel development using murine model systems: approaches and limitations

    Science.gov (United States)

    Pugach, Megan K.; Gibson, Carolyn W.

    2014-01-01

    A primary goal of enamel research is to understand and potentially treat or prevent enamel defects related to amelogenesis imperfecta (AI). Rodents are ideal models to assist our understanding of how enamel is formed because they are easily genetically modified, and their continuously erupting incisors display all stages of enamel development and mineralization. While numerous methods have been developed to generate and analyze genetically modified rodent enamel, it is crucial to understand the limitations and challenges associated with these methods in order to draw appropriate conclusions that can be applied translationally, to AI patient care. We have highlighted methods involved in generating and analyzing rodent enamel and potential approaches to overcoming limitations of these methods: (1) generating transgenic, knockout, and knockin mouse models, and (2) analyzing rodent enamel mineral density and functional properties (structure and mechanics) of mature enamel. There is a need for a standardized workflow to analyze enamel phenotypes in rodent models so that investigators can compare data from different studies. These methods include analyses of gene and protein expression, developing enamel histology, enamel pigment, degree of mineralization, enamel structure, and mechanical properties. Standardization of these methods with regard to stage of enamel development and sample preparation is crucial, and ideally investigators can use correlative and complementary techniques with the understanding that developing mouse enamel is dynamic and complex. PMID:25278900

  15. Analysis of enamel development using murine model systems: approaches and limitations.

    Directory of Open Access Journals (Sweden)

    Megan K Pugach

    2014-09-01

    Full Text Available A primary goal of enamel research is to understand and potentially treat or prevent enamel defects related to amelogenesis imperfecta (AI. Rodents are ideal models to assist our understanding of how enamel is formed because they are easily genetically modified, and their continuously erupting incisors display all stages of enamel development and mineralization. While numerous methods have been developed to generate and analyze genetically modified rodent enamel, it is crucial to understand the limitations and challenges associated with these methods in order to draw appropriate conclusions that can be applied translationally, to AI patient care. We have highlighted methods involved in generating and analyzing rodent enamel and potential approaches to overcoming limitations of these methods: 1 generating transgenic, knockout and knockin mouse models, and 2 analyzing rodent enamel mineral density and functional properties (structure, mechanics of mature enamel. There is a need for a standardized workflow to analyze enamel phenotypes in rodent models so that investigators can compare data from different studies. These methods include analyses of gene and protein expression, developing enamel histology, enamel pigment, degree of mineralization, enamel structure and mechanical properties. Standardization of these methods with regard to stage of enamel development and sample preparation is crucial, and ideally investigators can use correlative and complementary techniques with the understanding that developing mouse enamel is dynamic and complex.

  16. Strategy for a Rock Mechanics Site Descriptive Model. Development and testing of the theoretical approach

    Energy Technology Data Exchange (ETDEWEB)

    Staub, Isabelle; Fredriksson, Anders; Outters, Nils [Golder Associates AB, Uppsala (Sweden)

    2002-05-01

    In the purpose of studying the possibilities of a Deep Repository for spent fuel, the Swedish Nuclear and Fuel Management Company (SKB) is currently planning for Site Investigations. Data collected from these Site Investigations are interpreted and analysed to achieve the full Site Description, which is built up of models from all the disciplines that are considered of importance for the Site Description. One of these models is the Rock Mechanical Descriptive Model,which would be developed for any site in hard crystalline rock, and is a combination and evaluation of the characterisation of rock mass by means of empirical relationships and a theoretical approach based on numerical modelling. The present report describes the theoretical approach. The characterisation of the mechanical properties of the rock mass, viewed as a unit consisting of intact rock and fractures, is achieved by numerical simulations with following input parameters: initial stresses, fracture geometry, distribution of rock mechanical properties, such as deformation and strength parameters, for the intact rock and for the fractures. The numerical modelling was performed with the two-dimensional code UDEC, and the rock block models were generated from 2D trace sections extracted from the 3D Discrete Fracture Network (DFN) model. Assumptions and uncertainties related to the set-up of the model are considered. The numerical model was set-up to simulate a plain strain-loading test. Different boundary conditions were applied on the model for simulating stress conditions (I) in the undisturbed rock mass, and (II) at the proximity of a tunnel. In order to assess the reliability of the model sensitivity analyses have been conducted on some rock block models for defining the dependency of mechanical properties to in situ stresses, the influence of boundary conditions, rock material and joint constitutive models used to simulate the behaviour of intact rock and fractures, domain size and anisotropy. To

  17. Multiple Perspective Approach for the Development of Information Systems Based on Advanced Mathematical Models

    DEFF Research Database (Denmark)

    Carugati, Andrea

    with a relativist approach. Arriving at the design of an ISD methodology required the combination of previous theoretical results with the observations from the case study. The case study showed some of the key elements to be integrated in the methodology. Firstly, plans and models are subject of a high degree......This dissertation presents the results of a three-year long case study of an information systems development project where a scheduling and control system was developed for a manufacturing company. The project goal was to test the feasibility of a new technology called advanced mathematical...... organizations that are both distributed and loosely coupled. Given the current trends towards telecommuting and international mergers, the development project presented a setting for research that was addressing both a theoretical hole and also pressing practical needs. In order to achieve this goal I had...

  18. Developing a physiologically based approach for modeling plutonium decorporation therapy with DTPA.

    Science.gov (United States)

    Kastl, Manuel; Giussani, Augusto; Blanchardon, Eric; Breustedt, Bastian; Fritsch, Paul; Hoeschen, Christoph; Lopez, Maria Antonia

    2014-11-01

    To develop a physiologically based compartmental approach for modeling plutonium decorporation therapy with the chelating agent Diethylenetriaminepentaacetic acid (Ca-DTPA/Zn-DTPA). Model calculations were performed using the software package SAAM II (©The Epsilon Group, Charlottesville, Virginia, USA). The Luciani/Polig compartmental model with age-dependent description of the bone recycling processes was used for the biokinetics of plutonium. The Luciani/Polig model was slightly modified in order to account for the speciation of plutonium in blood and for the different affinities for DTPA of the present chemical species. The introduction of two separate blood compartments, describing low-molecular-weight complexes of plutonium (Pu-LW) and transferrin-bound plutonium (Pu-Tf), respectively, and one additional compartment describing plutonium in the interstitial fluids was performed successfully. The next step of the work is the modeling of the chelation process, coupling the physiologically modified structure with the biokinetic model for DTPA. RESULTS of animal studies performed under controlled conditions will enable to better understand the principles of the involved mechanisms.

  19. A Practical Approach of Developing Mathematical Model for All Speed Governors

    Institute of Scientific and Technical Information of China (English)

    WANG Yong-sheng; Dennis N. Assanis; ZHANG Yu-sheng

    2005-01-01

    The paper introduced a special approach for diesel's all-speed-governor modeling, which, in some cases,could solve the knotty problem frequently met in computer simulation of diesel propulsion system or diesel generating set. Suppose that it is hard to get a control-oriented governor mathematical model when the general approaches, the analytical approach or the experimental approach, are applied, and that an open-loop step response of the diesel engine and its system is available by means of computer simulation, the critical three parameters of a governor mathematical model, the proportional gain Kp, integral time constant Ki, and derivative time constant Kd, can be determined by use of PID tuning method which are widely applied in industrial process control. This paper discussed the train of thought of the approach, precondition, procedure, several modifications of the classical PID model, and some points for attention. A couple of case studies were given to demonstrate the effectiveness of this approach.

  20. Development of Agro-Horticultural Commodity Approach and Institutional Models in The District Of Madiun, Indonesia

    Directory of Open Access Journals (Sweden)

    Luluk Sulistiyo Budi

    2013-01-01

    Full Text Available The aim of research is how to approach the development of agro-horticultural commodities and institutional models in the Madiun district, East Java, Indonesia. The research Methods of using interviews, field studies and expert discussions are conducted in the region Agropolitan Madiun  distrrict. Analysis of component development using Analytic Hierarchy Process (AHP, the selection of commodities and institutional models using Exponential Method Comparison.  The result  showed that three main factors agro-horticultural development is influenced by market demand (0.219, government policy (0.164 and  the management of production systems (0.109. The main purpose is the increase in added value and competitiveness (0.211, social welfare (0.164, and local revenue (.143. The priority  commodities increased potential added value in a row is mango, banana, avocado, jackfruit, mangosteen and citrus. Alternative institutional model chosen is the first  of rural agro-industry cooperative and the second  is the group of the priority scale agro-products of fruit crisps (priority I, fruit syrup (priority II, various lunkhead (priority III, and sweets (priority IV.

  1. Quantifying second generation ethanol inhibition: Design of Experiments approach and kinetic model development.

    Science.gov (United States)

    Schneiderman, Steven J; Johnson, Roger W; Menkhaus, Todd J; Gilcrease, Patrick C

    2015-03-01

    While softwoods represent a potential feedstock for second generation ethanol production, compounds present in their hydrolysates can inhibit fermentation. In this study, a novel Design of Experiments (DoE) approach was used to identify significant inhibitory effects on Saccharomyces cerevisiae D5A for the purpose of guiding kinetic model development. Although acetic acid, furfural and 5-hydroxymethyl furfural (HMF) were present at potentially inhibitory levels, initial factorial experiments only identified ethanol as a significant rate inhibitor. It was hypothesized that high ethanol levels masked the effects of other inhibitors, and a subsequent factorial design without ethanol found significant effects for all other compounds. When these non-ethanol effects were accounted for in the kinetic model, R¯(2) was significantly improved over an ethanol-inhibition only model (R¯(2)=0.80 vs. 0.76). In conclusion, when ethanol masking effects are removed, DoE is a valuable tool to identify significant non-ethanol inhibitors and guide kinetic model development.

  2. A new approach to model the spatiotemporal development of biofilm phase in porous media.

    Science.gov (United States)

    Bozorg, Ali; Sen, Arindom; Gates, Ian D

    2011-11-01

    Bacteria can exist within biofilms that are attached to the solid matrix of a porous medium. Under certain conditions, the biomass can fully occupy the pore space leading to reduced hydraulic conductivity and mass transport. Here, by treating biofilm as a growing, high-viscosity phase, a novel macroscopic approach to model biofilm spatial expansion and its corresponding effects on porous medium hydraulic properties is presented. The separate yet coupled flow of the water and biofilm phases is handled by using relative permeability curves that allow for biofilm movement within the porous medium and bioclogging effects. Fluid flow is governed by Darcy's law and component transport is set by the convection-diffusion equation reaction terms for each component. Here, the system of governing equations is solved by using a commercial multiphase flow reservoir simulator, which is used to validate the model against published laboratory experiments. A comparison of the model and experimental observations reveal that the model provides a reasonable means to predict biomass development in the porous medium. The results reveal that coupled flow of water and movement of biofilm, as described by relative permeability curves, is complex and has a large impact on the development of biomass and consequent bioclogging in the porous medium.

  3. DEVELOPING "SEKOLAH PETERNAKAN RAKYAT" PROGRAM USING THE BUSINESS MODEL CANVAS APPROACH (CASE STUDY: BOJONEGORO REGENCY

    Directory of Open Access Journals (Sweden)

    Friesgina Wiska

    2016-05-01

    Full Text Available SPR Maju Bersama is one of the location where the concept of "Sekolah Peternakan Rakyat (SPR" is implemented, with the aim to encourage small-scale beef cattle breeder establish a professional collective enterprise under one management. SPR is designed to  change the mindset, knowledge and capability of the beef cattle breeder to become the best and self-reliant  entrepreneurs in the beef cattle business. In the effort to achieve its objective, the organization has not been able to carry out the model business effectively thus new strategies are needed to improve the business model. The objectives of this research are: 1 identify the present business model carried out by SPR Maju Bersama; 2 to carry out SWOT evaluation on each element of the business model; 3 formulate strategic to improve the business model that is formulated in an accurate programs. This research used the combination of business model canvas (BMC approach and SWOT matrix analysis. The results it is concluded that the SPR Maju Bersama need to improve the business model through alternatives strategies that have been developed include: 1 increase the number of farmer members; 2 apply the concept of "agrosilvopastura" to optimize the management of natural resources; 3 increase the intensity of assistance through e-learning; 4 improve the quality and intensity of the relationship between management and farmers; 5 develop curricula, programs and guide books as well as strengthen the system of membership; 6 expand the partnership by utilizing information technology and existing business partners; 7 establish training centers and services as a resource in the field of SPR and beef cattle; 8 utilizes a strong partnership to change the mindset of farmers; 9 increasing leadership skill and the ability to use communications technology in the management of SPR.Keywords: sekolah peternakan rakyat, Bojonegoro, BMC, matrix SWOT

  4. Benthic-Pelagic Coupling in Biogeochemical and Climate Models: Existing Approaches, Recent developments and Roadblocks

    Science.gov (United States)

    Arndt, Sandra

    2016-04-01

    the benthic-pelagic coupling that accounts for the complex process interplay from the euphotic ocean to the deep sediment. It explores the intensity of the benthic-pelagic coupling across different environments and from the seasonal to the geological timescale. Different modelling approaches of coupling sediment and water column dynamics in regional/global biogeochemical models and (paleo)climate models are critically evaluated and their most important limitations, as well as the implications for our ability to predict the response of the global carbon cycle to past or future perturbations is discussed. Finally, the presentation identifies major roadblocks to the development of new model approaches and highlights how new techniques, new observational and laboratory data, as well as a close interdisciplinary collaboration can overcome these roadblocks.

  5. Geospatial Modeling and Simulation Based Approach for Developing Commuting patterns of School Children

    Energy Technology Data Exchange (ETDEWEB)

    Bhaduri, Budhendra L [ORNL; Liu, Cheng [ORNL; Nutaro, James J [ORNL; Patterson, Lauren A [ORNL

    2008-01-01

    Numerous socio-environmental studies, including those in public health, utilize population data as one of the essential elements of modeling and analysis. Typically population data are reported by administrative or accounting units. For example, in the US the Census Bureau reports population counts by census blocks, block groups, and tracts. At any resolution, a uniform population distribution is assumed and the population figures and demographic characteristics are typically associated with block (polygon) centroids. In geographic analyses these points are considered representative of the population for census polygons. Traditional spatial modeling approaches commonly include intersection of census data with buffers of influence to quantify target population, using either inclusion-exclusion (of the centroids) or the area weighted population estimation methods. However, it is well understood that uniform population distribution is the weakest assumption and by considering census polygon centroids as representative of population all analytical approaches are very likely to overestimate or underestimate the analytical results. Given that population is spatially restricted by Census accounting units (such as blocks), there often is great uncertainty about spatial distribution of residents within those accounting units. This is particularly appropriate in suburban and rural areas, where the population is dispersed to a greater degree than urban areas. Because of this uncertainty, there is significant potential to misclassify people with respect to their location from pollution sources, and consequently it becomes challenging to determine if certain sub-populations are actually more likely than others to get differential environmental exposure. In this paper, we describe development and utilization of a high resolution demographic data driven approach for modeling and simulation at Oak Ridge National Laboratory.

  6. Developing sustainable models of rural health care: a community development approach.

    Science.gov (United States)

    Allan, J; Ball, P; Alston, M

    2007-01-01

    Globally, small rural communities frequently are demographically similar to their neighbours and are consistently found to have a number of problems linked to the international phenomenon of rural decline and urban drift. For example, it is widely noted that rural populations have poor health status and aging populations. In Australia, multiple state and national policies and programs have been instigated to redress this situation. Yet few rural residents would agree that their town is the same as an apparently similar sized one nearby or across the country. This article reports a project that investigated the way government policies, health and community services, population characteristics and local peculiarities combined for residents in two small rural towns in New South Wales. Interviews and focus groups with policy makers, health and community service workers and community members identified the felt, expressed, normative and comparative needs of residents in the case-study towns. Key findings include substantial variation in service provision between towns because of historical funding allocations, workforce composition, natural disasters and distance from the nearest regional centre. Health and community services were more likely to be provided because of available funding, rather than identified community needs. While some services, such as mental illness intervention and GPs, are clearly in demand in rural areas, in these examples, more health services were not needed. Rather, flexibility in the services provided and work practices, role diversity for health and community workers and community profiling would be more effective to target services. The impact of industry, employment and recreation on health status cannot be ignored in local development.

  7. Modelling the impact of mining on socio-economic infrastructure development: a system dynamics approach

    Directory of Open Access Journals (Sweden)

    Maluleke, George

    2016-12-01

    Full Text Available The contribution of mining activities to social infrastructure and human development is a complex socio-economic development issue in South Africa. Complexity theory has introduced a new approach to solving problems in social systems, recognising them as complex systems. The socio-economic development system in South Africa falls into this category of complex systems. Analysing such a system requires that a number of feedback loops and details about the issues be analysed simultaneously. This level of complexity is above a human’s ability to comprehend without the aid of tools such as systems thinking and system dynamics. The causality between investment in infrastructure capacity and socio-economic development is dynamic. The relationship is influenced by exogenous feedback that, if not managed, is likely to reverse itself. This paper presents the results of a system dynamics modelling of the relationship, based on the principle of relative attractiveness developed in previous system dynamics research. A Monte Carlo analysis is used to determine the sensitivity of the system to changes in feedback. The paper concludes that the limits to growth in a socio-economic environment are determined by more factors than the availability of capital, and also include land capacity constraints and skills shortage.

  8. A Multiphase Approach to the Modeling of Porous Media Contamination by Organic Compounds: 1. Equation Development

    Science.gov (United States)

    Abriola, Linda M.; Pinder, George F.

    1985-01-01

    A multiphase approach to the modeling of aquifer contamination by organic compounds is developed. This approach makes it possible to describe the simultaneous transport of a chemical contaminant in three physical forms: as a nonaqueous phase, as a soluble component of an aqueous phase, and as a mobile fraction of a gas phase. The contaminant may be composed of, at most, two distinct components, one of which may be volatile and slightly water soluble and the other of which is both nonvolatile and insoluble in water. Equations which describe this complex system are derived from basic conservation of mass principles by the application of volume averaging techniques and the incorporation of various constitutive relations and approximations. Effects of matrix and fluid compressibilities, gravity, phase composition, interphase mass exchange, capillarity, diffusion, and dispersion are all considered. The resulting mathematical model consists of a system of three nonlinear partial differential equations subject to two equilibrium constraints. These equations relate five unknowns: two capillary pressures and three mass fractions.

  9. A cell-based computational modeling approach for developing site-directed molecular probes.

    Directory of Open Access Journals (Sweden)

    Jing-Yu Yu

    Full Text Available Modeling the local absorption and retention patterns of membrane-permeant small molecules in a cellular context could facilitate development of site-directed chemical agents for bioimaging or therapeutic applications. Here, we present an integrative approach to this problem, combining in silico computational models, in vitro cell based assays and in vivo biodistribution studies. To target small molecule probes to the epithelial cells of the upper airways, a multiscale computational model of the lung was first used as a screening tool, in silico. Following virtual screening, cell monolayers differentiated on microfabricated pore arrays and multilayer cultures of primary human bronchial epithelial cells differentiated in an air-liquid interface were used to test the local absorption and intracellular retention patterns of selected probes, in vitro. Lastly, experiments involving visualization of bioimaging probe distribution in the lungs after local and systemic administration were used to test the relevance of computational models and cell-based assays, in vivo. The results of in vivo experiments were consistent with the results of in silico simulations, indicating that mitochondrial accumulation of membrane permeant, hydrophilic cations can be used to maximize local exposure and retention, specifically in the upper airways after intratracheal administration.

  10. Developing a model for effective leadership in healthcare: a concept mapping approach

    Directory of Open Access Journals (Sweden)

    Hargett CW

    2017-08-01

    Full Text Available Charles William Hargett,1 Joseph P Doty,2 Jennifer N Hauck,3 Allison MB Webb,4 Steven H Cook,5 Nicholas E Tsipis,4 Julie A Neumann,6 Kathryn M Andolsek,7 Dean C Taylor6 1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, 2Feagin Leadership Program, 3Department of Anesthesiology, 4School of Medicine, 5Department of Neurosurgery, 6Department of Orthopaedic Surgery, 7Department of Community and Family Medicine, Duke University School of Medicine, Durham, NC, USA Purpose: Despite increasing awareness of the importance of leadership in healthcare, our understanding of the competencies of effective leadership remains limited. We used a concept mapping approach (a blend of qualitative and quantitative analysis of group processes to produce a visual composite of the group’s ideas to identify stakeholders’ mental model of effective healthcare leadership, clarifying the underlying structure and importance of leadership competencies.Methods: Literature review, focus groups, and consensus meetings were used to derive a representative set of healthcare leadership competency statements. Study participants subsequently sorted and rank-ordered these statements based on their perceived importance in contributing to effective healthcare leadership in real-world settings. Hierarchical cluster analysis of individual sortings was used to develop a coherent model of effective leadership in healthcare.Results: A diverse group of 92 faculty and trainees individually rank-sorted 33 leadership competency statements. The highest rated statements were “Acting with Personal Integrity”, “Communicating Effectively”, “Acting with Professional Ethical Values”, “Pursuing Excellence”, “Building and Maintaining Relationships”, and “Thinking Critically”. Combining the results from hierarchical cluster analysis with our qualitative data led to a healthcare leadership model based on the core principle of Patient

  11. Biobankonomics: developing a sustainable business model approach for the formation of a human tissue biobank.

    Science.gov (United States)

    Vaught, Jimmie; Rogers, Joyce; Carolin, Todd; Compton, Carolyn

    2011-01-01

    The preservation of high-quality biospecimens and associated data for research purposes is being performed in variety of academic, government, and industrial settings. Often these are multimillion dollar operations, yet despite these sizable investments, the economics of biobanking initiatives is not well understood. Fundamental business principles must be applied to the development and operation of such resources to ensure their long-term sustainability and maximize their impact. The true costs of developing and maintaining operations, which may have a variety of funding sources, must be better understood. Among the issues that must be considered when building a biobank economic model are: understanding the market need for the particular type of biobank under consideration and understanding and efficiently managing the biobank's "value chain," which includes costs for case collection, tissue processing, storage management, sample distribution, and infrastructure and administration. By using these value chain factors, a Total Life Cycle Cost of Ownership (TLCO) model may be developed to estimate all costs arising from owning, operating, and maintaining a large centralized biobank. The TLCO approach allows for a better delineation of a biobank's variable and fixed costs, data that will be needed to implement any cost recovery program. This article represents an overview of the efforts made recently by the National Cancer Institute's Office of Biorepositories and Biospecimen Research as part of its effort to develop an appropriate cost model and cost recovery program for the cancer HUman Biobank (caHUB) initiative. All of these economic factors are discussed in terms of maximizing caHUB's potential for long-term sustainability but have broad applicability to the wide range of biobanking initiatives that currently exist.

  12. Developing a Teaching Model Using an Online Collaboration Approach for a Digital Technique Practical Work

    Science.gov (United States)

    Muchlas

    2015-01-01

    This research is aimed to produce a teaching model and its supporting instruments using a collaboration approach for a digital technique practical work attended by higher education students. The model is found to be flexible and relatively low cost. Through this research, feasibility and learning impact of the model will be determined. The model…

  13. Cluster approach to forming innovative model of developing mineral resources base of Russia’s regions

    Directory of Open Access Journals (Sweden)

    Andrey Gennad'evich Shelomentsev

    2012-03-01

    Full Text Available In this paper, the necessity of applying innovative model of developing mineral resources base of Russia’s regions and relevance of cluster approach for forming this model are proved. Components of process of clustering in the case of innovative developing mineral raw complex are proposed and analyzed: consolidation of socioeconomic potential of region, consolidation of potential of different branches of people’s activities, consolidation of processes of primary (wining sector in the single chain. In particular, the first component implies concentration of population in certain centers of gravitation. The second component implies consolidation of education, fundamental as well as applying science and production. The creating of administrative nets is necessary for that. For the realization of the first and the second components, the availability of clustering organization is necessary. The third component of process of clustering implies in prospect the adding of increasing amount of stages of product manufacturing. Eventually, the multi-stage structure of innovative process is analyzed.

  14. A Theoretical Approach to Financial Therapy: The Development of the Ford Financial Empowerment Model

    OpenAIRE

    Kristy L. Archuleta; Joyce A. Baptist; Megan R. Ford

    2012-01-01

    The purpose of this paper is to introduce an integrative approach to working with clients experiencing problems related to financial disempowerment. The multi-phase model integrates three theoretically-driven psychotherapy approaches, including cognitive behavioral, narrative, and Virginia Satir’s experiential therapies, and financial counseling techniques to increase one’s sense of financial empowerment. A case study is included to demonstrate the applicability and effectiveness of the model...

  15. A Theoretical Approach to Financial Therapy: The Development of the Ford Financial Empowerment Model

    OpenAIRE

    Kristy L. Archuleta; Joyce A. Baptist; Megan R. Ford

    2012-01-01

    The purpose of this paper is to introduce an integrative approach to working with clients experiencing problems related to financial disempowerment. The multi-phase model integrates three theoretically-driven psychotherapy approaches, including cognitive behavioral, narrative, and Virginia Satir’s experiential therapies, and financial counseling techniques to increase one’s sense of financial empowerment. A case study is included to demonstrate the applicability and effectiveness of the model...

  16. Hydrologic Model Development and Calibration: Contrasting a Single- and Multi-Objective Approach for Comparing Model Performance

    Science.gov (United States)

    Asadzadeh, M.; Maclean, A.; Tolson, B. A.; Burn, D. H.

    2009-05-01

    Hydrologic model calibration aims to find a set of parameters that adequately simulates observations of watershed behavior, such as streamflow, or a state variable, such as snow water equivalent (SWE). There are different metrics for evaluating calibration effectiveness that involve quantifying prediction errors, such as the Nash-Sutcliffe (NS) coefficient and bias evaluated for the entire calibration period, on a seasonal basis, for low flows, or for high flows. Many of these metrics are conflicting such that the set of parameters that maximizes the high flow NS differs from the set of parameters that maximizes the low flow NS. Conflicting objectives are very likely when different calibration objectives are based on different fluxes and/or state variables (e.g., NS based on streamflow versus SWE). One of the most popular ways to balance different metrics is to aggregate them based on their importance and find the set of parameters that optimizes a weighted sum of the efficiency metrics. Comparing alternative hydrologic models (e.g., assessing model improvement when a process or more detail is added to the model) based on the aggregated objective might be misleading since it represents one point on the tradeoff of desired error metrics. To derive a more comprehensive model comparison, we solved a bi-objective calibration problem to estimate the tradeoff between two error metrics for each model. Although this approach is computationally more expensive than the aggregation approach, it results in a better understanding of the effectiveness of selected models at each level of every error metric and therefore provides a better rationale for judging relative model quality. The two alternative models used in this study are two MESH hydrologic models (version 1.2) of the Wolf Creek Research basin that differ in their watershed spatial discretization (a single Grouped Response Unit, GRU, versus multiple GRUs). The MESH model, currently under development by Environment

  17. Integrated approaches to the application of advanced modeling technology in process development and optimization

    Energy Technology Data Exchange (ETDEWEB)

    Allgor, R.J.; Feehery, W.F.; Tolsma, J.E. [Massachusetts Institute of Technology, Cambridge, MA (United States)] [and others

    1995-12-31

    The batch process development problem serves as good candidate to guide the development of process modeling environments. It demonstrates that very robust numerical techniques are required within an environment that can collect, organize, and maintain the data and models required to address the batch process development problem. This paper focuses on improving the robustness and efficiency of the numerical algorithms required in such a modeling environment through the development of hybrid numerical and symbolic strategies.

  18. Learning Outcomes in Vocational Education: A Business Plan Development by Production-Based Learning Model Approach

    Science.gov (United States)

    Kusumaningrum, Indrati; Hidayat, Hendra; Ganefri; Anori, Sartika; Dewy, Mega Silfia

    2016-01-01

    This article describes the development of a business plan by using production-based learning approach. In addition, this development also aims to maximize learning outcomes in vocational education. Preliminary analysis of curriculum and learning and the needs of the market and society become the basic for business plan development. To produce a…

  19. Model Youth Programs: A Key Strategy for Developing Community-University Partnerships Using a Community Youth Development Approach

    Directory of Open Access Journals (Sweden)

    Yolanda Anyon

    2008-06-01

    Full Text Available Universities across the nation face the charge of enhancing their intellectual capital as a learning institution while also contributing to the greater social good. While there is great potential for university-community partnerships to generate lessons for youth workers and policy makers, create powerful new knowledge for the academic field, and provide transformative experiences for community members, partnerships often fail to produce such meaningful results. In the San Francisco Bay Area, community residents who have been involved in such unsuccessful initiatives frequently perceived that university partners spent insufficient time learning about the community context, prioritized research objectives over community needs and did not make long-term commitments. Despite these challenges, community-university partnerships can be useful strategies for advancing the field of youth development by strengthening research and practice in local contexts. This paper presents how the design and implementation of model youth programs served as an effective strategy in developing a partnership between a university-based center and two local communities over a 5-year period. It also describes essential lessons that other communities, research institutions or universities may use to launch, implement, expand and sustain their own successful partnerships to build local capacity to implement youth development practices, promote positive outcomes for young people, and generate knowledge about the impact of youth development approaches.

  20. Development of Antiatherosclerotic Drugs on the basis of Natural Products Using Cell Model Approach

    Directory of Open Access Journals (Sweden)

    Alexander N. Orekhov

    2015-01-01

    Full Text Available Atherosclerosis including its subclinical form is one of the key medical and social problems. At present, there is no therapy available for widespread use against subclinical atherosclerosis. The use of synthetic drugs for the prevention of arteriosclerosis in its early stages is not sufficient because of the limited indications for severe side effects and high cost of treatment. Obviously, effective antiatherosclerotic drugs based on natural products would be a preferred alternative. Simple cell-based models for testing different natural products have been developed and the ability of natural products to prevent intracellular lipid accumulation in primary cell culture was evaluated. This approach utilizing cell models allowed to test effects of such direct antiatherosclerotic therapy, analyzing the effects mimicking those which can occur “at the level” of arterial wall via the inhibition of intracellular lipid deposition. The data from the carried out clinical trials support a point of view that the identification of antiatherosclerotic activity of natural products might offer a great opportunity for the prevention and treatment of atherosclerotic disease, reducing cardiovascular morbidity and mortality.

  1. An investigation of a professional development model in science education: A systems approach

    Science.gov (United States)

    Bell, Glenda Love

    The Mathematics and Science Cooperative (MSEC), a four year longevity model of professional development education for in-service teachers, is closely aligned with the spirit and tenets of science for all. This partnership of a university, a school district, and a higher education coordinating board, seeks to promote and improve science and mathematics achievement for underserved and underrepresented populations. This study sought to explore how this model affects elementary in-service teachers' feelings of self-efficacy toward science and science teaching. Interactive Qualitative Research (IQR), a systems approach of natural inquiry, was used for this study. Theory is grounded in the data collected and analyzed through group processes. A core group of teachers, key teachers representing grades one through six and lead teachers the campus contact representatives, received professional development education from university professors in semi-monthly after school workshops and in a three week summer science institute held on-site. In this study, (N = 18) key and lead teachers participated in a focus group, a picture board exercise (a projective type exercise), interviews, and classroom observations. Within the system of the MSEC professional development model, cause and effect relationships among eleven phenomena were identified which had the greatest impact on the teachers' feelings of self-efficacy and science teaching practices. Changed teaching practices were indicated by inquiry-based science lessons with students as active learners. Five principles of self-efficacy: (1) efficacy; (2) goals setting; (3) values; (4) expectancy; and, (5) control beliefs were used to evaluate efficacy beliefs. Findings from the data collection and analysis identified two phenomena, the university instructional leadership role and teacher time commitments and time constraints, both internally and externally imposed, which seemed to have the greatest impact on elementary teachers

  2. Structured Mental Model Approach for Analyzing Perception of Risks to Rural Livelihood in Developing Countries

    Directory of Open Access Journals (Sweden)

    Claudia R. Binder

    2009-12-01

    Full Text Available This paper presents the Structural Mental Model Approach aimed at understanding differences in perception between experts and farmers regarding the various livelihood risks farmers are confronted with. The SMMA combines the Sustainable Livelihood Framework with the Mental Model Approach and consists of three steps: (i definition and weighting of different livelihood capitals; (ii analysis of livelihood dynamics, and (iii definition of the social capital by means of agent networks. The results provide a sound basis for the design of sustainable policy interventions such as communication and educational programs which consider farmers’ priorities and viewpoints.

  3. Development of an Electronic Portfolio System Success Model: An Information Systems Approach

    Science.gov (United States)

    Balaban, Igor; Mu, Enrique; Divjak, Blazenka

    2013-01-01

    This research has two main goals: to develop an instrument for assessing Electronic Portfolio (ePortfolio) success and to build a corresponding ePortfolio success model using DeLone and McLean's information systems success model as the theoretical framework. For this purpose, we developed an ePortfolio success measurement instrument and structural…

  4. A Bayesian inference approach to the development of a multidirectional pedestrian stream model

    OpenAIRE

    2015-01-01

    In this paper, we develop a mathematical model to represent the conflicting effects of multidirectional pedestrian flows in a large crowd. The model is formulated based on Drake's model of traffic flow. Rather than relate the speed of a pedestrian stream solely to the pedestrian density, we introduce the flow ratio and intersecting angle between streams as variables. To calibrate the model, data collection was conducted through the video recording of pedestrian movements on a pedestrian stree...

  5. Institutional Approach to Establishment of a Structural Model of the Russian Academic Environment Development

    Science.gov (United States)

    Dudin, Mikhail N.; Ivashchenko, Natalia P.; Frolova, ?vgenia ?.; Abashidze, Aslan H.

    2017-01-01

    The purpose of the present article is to generalize and unify the approaches to improvement of the institutional environment that ensures optimal functioning and sustainable development of the Russian academic sphere. The following conclusions and results have been obtained through presentation of the materials in the article: (1) Improvement of…

  6. Positive Mathematical Programming Approaches – Recent Developments in Literature and Applied Modelling

    Directory of Open Access Journals (Sweden)

    Thomas Heckelei

    2012-05-01

    Full Text Available This paper reviews and discusses the more recent literature and application of Positive Mathematical Programming in the context of agricultural supply models. Specifically, advances in the empirical foundation of parameter specifications as well as the economic rationalisation of PMP models – both criticized in earlier reviews – are investigated. Moreover, the paper provides an overview on a larger set of models with regular/repeated policy application that apply variants of PMP. Results show that most applications today avoid arbitrary parameter specifications and rely on exogenous information on supply responses to calibrate model parameters. However, only few approaches use multiple observations to estimate parameters, which is likely due to the still considerable technical challenges associated with it. Equally, we found only limited reflection on the behavioral or technological assumptions that could rationalise the PMP model structure while still keeping the model’s advantages.

  7. A behavioural modelling approach to curriculum development and evaluation of health promotion for nurses.

    Science.gov (United States)

    Kelly, M P; Maloney, W A

    1992-05-01

    This paper outlines the way in which two behavioural science models may be used in the processes of curriculum development and course evaluation. The models are the stress-coping paradigm associated with the work of Lazarus and the theory of self and identity developed from the work of Mead. It is suggested that a clear articulation of the underlying behavioural processes is fundamental in course design and appraisal.

  8. Development of cell differentiation in the transition to multicellularity: a dynamical modeling approach

    Science.gov (United States)

    Mora Van Cauwelaert, Emilio; Arias Del Angel, Juan A.; Benítez, Mariana; Azpeitia, Eugenio M.

    2015-01-01

    Multicellularity has emerged and continues to emerge in a variety of lineages and under diverse environmental conditions. In order to attain individuality and integration, multicellular organisms must exhibit spatial cell differentiation, which in turn allows cell aggregates to robustly generate traits and behaviors at the multicellular level. Nevertheless, the mechanisms that may lead to the development of cellular differentiation and patterning in emerging multicellular organisms remain unclear. We briefly review two conceptual frameworks that have addressed this issue: the cooperation-defection framework and the dynamical patterning modules (DPMs) framework. Then, situating ourselves in the DPM formalism first put forward by S. A. Newman and collaborators, we state a hypothesis for cell differentiation and arrangement in cellular masses of emerging multicellular organisms. Our hypothesis is based on the role of the generic cell-to-cell communication and adhesion patterning mechanisms, which are two fundamental mechanisms for the evolution of multicellularity, and whose molecules seem to be well-conserved in extant multicellular organisms and their unicellular relatives. We review some fundamental ideas underlying this hypothesis and contrast them with empirical and theoretical evidence currently available. Next, we use a mathematical model to illustrate how the mechanisms and assumptions considered in the hypothesis we postulate may render stereotypical arrangements of differentiated cells in an emerging cellular aggregate and may contribute to the variation and recreation of multicellular phenotypes. Finally, we discuss the potential implications of our approach and compare them to those entailed by the cooperation-defection framework in the study of cell differentiation in the transition to multicellularity. PMID:26157427

  9. Model-based approaches to support process improvement in complex product development

    OpenAIRE

    Wynn, David C.

    2007-01-01

    The performance of product development processes is important to the commercial success of new products. The improvement of these processes is thus a strategic imperative for many engineering companies — the aero-engine is one example of a complex product for which market pressures necessitate ever-shorter development times. This thesis argues that process modelling and simulation can support the improvement of complex product development processes. A literature review identified that desi...

  10. Developing an Approach to Model UV Fluxes in Smoke Laden Conditions over Central Asia

    Science.gov (United States)

    Park, Y. H.; Sokolik, I. N.

    2016-12-01

    The UV characteristics of smoke aerosols are valuable inputs to the UV Index forecasts, air quality studies, and assessments of the impact of regional environmental changes. The wavelength dependence of light absorption by aerosol particles is pronounced throughout the UV spectral region. Also in assumption that smoke consists of BC, OC, and Sulfate, the mass fraction of smoke is different with fire types. The purpose of this study is to introduce an approach to calculate the UV fluxes in the aerosol laden conditions, and investigate the irradiance compared to measured irradiance in the UV spectrum. To compute the spectral optical properties (e.g., the effective single scattering albedo, asymmetry parameter, and aerosol optical thickness) for the selected scenarios, the representative size distribution and the refractive index are selected and used in the Mie code. Smoke aerosol information (e.g. emission injection height, mass concentration of smoke components) from WRF Chem is applied to run tropospheric ultraviolet and visible (TUV) model. Using the TUV model, we make the comparisons between model and measured irradiance in UV spectrum in smoke aerosol conditions. An advantage of this approach and the uncertainty of the evaluation are discussed. Overall, the results of this investigation show that this approach is valuable to estimate UV fluxes in smoke laden conditions.

  11. Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents.

    Science.gov (United States)

    Boyle, C J; Lennon, A B; Early, M; Kelly, D J; Lally, C; Prendergast, P J

    2010-06-28

    The design of medical devices could be very much improved if robust tools were available for computational simulation of tissue response to the presence of the implant. Such tools require algorithms to simulate the response of tissues to mechanical and chemical stimuli. Available methodologies include those based on the principle of mechanical homeostasis, those which use continuum models to simulate biological constituents, and the cell-centred approach, which models cells as autonomous agents. In the latter approach, cell behaviour is governed by rules based on the state of the local environment around the cell; and informed by experiment. Tissue growth and differentiation requires simulating many of these cells together. In this paper, the methodology and applications of cell-centred techniques--with particular application to mechanobiology--are reviewed, and a cell-centred model of tissue formation in the lumen of an artery in response to the deployment of a stent is presented. The method is capable of capturing some of the most important aspects of restenosis, including nonlinear lesion growth with time. The approach taken in this paper provides a framework for simulating restenosis; the next step will be to couple it with more patient-specific geometries and quantitative parameter data.

  12. A Bayesian network approach to knowledge integration and representation of farm irrigation: 1. Model development

    Science.gov (United States)

    Wang, Q. J.; Robertson, D. E.; Haines, C. L.

    2009-02-01

    Irrigation is important to many agricultural businesses but also has implications for catchment health. A considerable body of knowledge exists on how irrigation management affects farm business and catchment health. However, this knowledge is fragmentary; is available in many forms such as qualitative and quantitative; is dispersed in scientific literature, technical reports, and the minds of individuals; and is of varying degrees of certainty. Bayesian networks allow the integration of dispersed knowledge into quantitative systems models. This study describes the development, validation, and application of a Bayesian network model of farm irrigation in the Shepparton Irrigation Region of northern Victoria, Australia. In this first paper we describe the process used to integrate a range of sources of knowledge to develop a model of farm irrigation. We describe the principal model components and summarize the reaction to the model and its development process by local stakeholders. Subsequent papers in this series describe model validation and the application of the model to assess the regional impact of historical and future management intervention.

  13. Thermodynamic modeling of small scale biomass gasifiers: Development and assessment of the ''Multi-Box'' approach.

    Science.gov (United States)

    Vakalis, Stergios; Patuzzi, Francesco; Baratieri, Marco

    2016-04-01

    Modeling can be a powerful tool for designing and optimizing gasification systems. Modeling applications for small scale/fixed bed biomass gasifiers have been interesting due to their increased commercial practices. Fixed bed gasifiers are characterized by a wide range of operational conditions and are multi-zoned processes. The reactants are distributed in different phases and the products from each zone influence the following process steps and thus the composition of the final products. The present study aims to improve the conventional 'Black-Box' thermodynamic modeling by means of developing multiple intermediate 'boxes' that calculate two phase (solid-vapor) equilibriums in small scale gasifiers. Therefore the model is named ''Multi-Box''. Experimental data from a small scale gasifier have been used for the validation of the model. The returned results are significantly closer with the actual case study measurements in comparison to single-stage thermodynamic modeling.

  14. Modeling egg development of the pest Clavipalpus ursinus (Coleoptera: Melolonthidae) using a temperature-dependent approach

    Institute of Scientific and Technical Information of China (English)

    Andrea Escobar; Rodrigo Gil; Carlos Ricardo Bojacá; Jaime Jiménez

    2012-01-01

    Predicting the population dynamics of insects in natural conditions is essential for their management or preservation,and temperature-dependent development models contribute to achieving this.In this research the effects of temperature and soil moisture content on egg development and hatching of Clavipalpus ursinus (Blanchard)were evaluated.The eggs were exposed to seven temperature treatments with averages of 7.2,13.0,15.5,19.7,20.6,22.0 and 25.3℃,in combination with three soil moisture contents of 40%,60% and 80%.A linear and two non-linear (Lactin and Briere) models were evaluated in order to determine the thermal requirements of this developmental stage.Temperature affected significantly the time of development and egg hatching,while no significant effect was observed for moisture content.Thermal requirements were set as:7.2℃ for lower developmental threshold,20.6℃ for optimum developmental threshold,25.3℃ for maximum temperature and 344.83 degree-days for the thermal constant.The linear model described satisfactorily egg development at intermediate temperatures; nevertheless,a slightly better fit of the observed data was obtained with the Lactin model.Egg development took place inside a narrow range of temperatures.Consequently,an increment of soil temperature could generate a negative impact on the population size of this species or changes in its biological parameters.

  15. A system dynamics approach to develop a recovery model in the Malaysian automotive industry

    Science.gov (United States)

    Mohamad-Ali, N.; Ghazilla, R. A. R.; Abdul-Rashid, S. H.; Sakundarini, N.; Ahmad-Yazid, A.; Stephenie, L.

    2017-06-01

    Design strategies play a significant role to enhance recovery effectiveness at the end of product life cycle. By reviewing previous study, there are many factors involved to enhance recovery effectiveness but limited to linking design strategies factors in holistic and dynamics view. Proposed method are explained and an initial model for end-of-life vehicles (ELVs) recovery model illustrated in graphical and numerical data is presented. However this is limited to authors understanding and preliminary data which requires collaboration between designers and other stakeholders to develop a model based on actual situation.

  16. A quantitative approach to developing more mechanistic gas exchange models for field grown potato

    DEFF Research Database (Denmark)

    Ahmadi, Seyed Hamid; Andersen, Mathias Neumann; Poulsen, Rolf Thostrup

    2009-01-01

    of chemical and hydraulic signalling on stomatal conductance as exp(-β[ABA])exp(-δ|ψ|) in which [ABA] and |ψ| are xylem ABA concentration and absolute value of leaf or stem water potential. In this study we found that stem water potential could be a very reliable indicator of how plant water status affects......In this study we introduce new gas exchange models that are developed under natural conditions of field grown potato. The new models could explain about 85% of the stomatal conductance variations, which was much higher than the well-known gas exchange models such as the Ball-Berry model [Ball......, Woodrow, Berry, 1987. In: Nijhoff, M. (Eds.), Progress in Photosynthesis Research, vol. 4. Dordrecht, The Netherlands, pp. 5.221-5.224]. To overcome the limitations of previous models in simulating stomatal conductance when plants are exposed to drought stress, we proposed a down-regulating factor...

  17. Strategy for a Rock Mechanics Site Descriptive Model. Development and testing of the empirical approach

    Energy Technology Data Exchange (ETDEWEB)

    Roeshoff, Kennert; Lanaro, Flavio [Berg Bygg Konsult AB, Stockholm (Sweden); Lanru Jing [Royal Inst. of Techn., Stockholm (Sweden). Div. of Engineering Geology

    2002-05-01

    This report presents the results of one part of a wide project for the determination of a methodology for the determination of the rock mechanics properties of the rock mass for the so-called Aespoe Test Case. The Project consists of three major parts: the empirical part dealing with the characterisation of the rock mass by applying empirical methods, a part determining the rock mechanics properties of the rock mass through numerical modelling, and a third part carrying out numerical modelling for the determination of the stress state at Aespoe. All Project's parts were performed based on a limited amount of data about the geology and mechanical tests on samples selected from the Aespoe Database. This Report only considers the empirical approach. The purpose of the project is the development of a descriptive rock mechanics model for SKBs rock mass investigations for a final repository site. The empirical characterisation of the rock mass provides correlations with some of the rock mechanics properties of the rock mass such as the deformation modulus, the friction angle and cohesion for a certain stress interval and the uniaxial compressive strength. For the characterisation of the rock mass, several empirical methods were analysed and reviewed. Among those methods, some were chosen because robust, applicable and widespread in modern rock mechanics. Major weight was given to the well-known Tunnel Quality Index (Q) and Rock Mass Rating (RMR) but also the Rock Mass Index (RMi), the Geological Strength Index (GSI) and Ramamurthy's Criterion were applied for comparison with the two classical methods. The process of: i) sorting the geometrical/geological/rock mechanics data, ii) identifying homogeneous rock volumes, iii) determining the input parameters for the empirical ratings for rock mass characterisation; iv) evaluating the mechanical properties by using empirical relations with the rock mass ratings; was considered. By comparing the methodologies involved

  18. Factors Affecting Malnutrition in Developing Countries: A Linear Mixed Model Approach

    Directory of Open Access Journals (Sweden)

    Sohair F. Higazi

    2012-11-01

    Full Text Available  AbstractThe main objective of this study is to pinpoint the main factors that affect the percentage who suffers of malnutrition in developing countries. Three locations are randomly chosen: Asia, Africa, and Middle east and North Africa ( MENA; A total of 96 countries were chosen randomly from 137  developing countries of the three locations; and were cross classified by " Location" and  " Human Development Index (HDI as high, middle, and low (UNDP,  2005.  Data for the study was compiled from FAO (2005. The analysis started with seven explanatory variables and the dependent variable; however, stepwise regression reveals that the average Protein intake and Infant mortality rate were the only two significant variables. "Location and "HDI" are dummy coded and OLS regression is performed using the two significant variables, but the only significant variable was the "average protein intake". OLS multiple regression Model is re-applied to the data using dummy variables technique with interaction with the "average Protein intake", nine regression equations were reached.The Linear Mixed effect Models are also applied, using "location" as the random factor and "HDI" as the fixed factor. Five models were applied: (1 a null model (baseline modelwhere no predictors are introduced to the model; (2 the fixed model: where predictors used are the  covariate and the HDI; (3 the random model: where predictors used are  the covariate and Location ; (4 the mixed model: where predictors used are the covariate and the HDI I  ( fixed and the location( random; and (5 the random coefficient model: where predictors used are  the covariate ,  the HDI Index  and the location but produces different prediction equations that differ in slopes and intercepts. Models are compared based on information criterions. The random coefficient model produces the least criterion values and thus fits better than all previous ones. A comparison between the Random Coefficient

  19. Factors Affecting Malnutrition in Developing Countries: A Linear Mixed Model Approach

    Directory of Open Access Journals (Sweden)

    Sohair F. Higazi

    2012-11-01

    Full Text Available  AbstractThe main objective of this study is to pinpoint the main factors that affect the percentage who suffers of malnutrition in developing countries. Three locations are randomly chosen: Asia, Africa, and Middle east and North Africa ( MENA; A total of 96 countries were chosen randomly from 137  developing countries of the three locations; and were cross classified by " Location" and  " Human Development Index (HDI as high, middle, and low (UNDP,  2005.  Data for the study was compiled from FAO (2005. The analysis started with seven explanatory variables and the dependent variable; however, stepwise regression reveals that the average Protein intake and Infant mortality rate were the only two significant variables. "Location and "HDI" are dummy coded and OLS regression is performed using the two significant variables, but the only significant variable was the "average protein intake". OLS multiple regression Model is re-applied to the data using dummy variables technique with interaction with the "average Protein intake", nine regression equations were reached.The Linear Mixed effect Models are also applied, using "location" as the random factor and "HDI" as the fixed factor. Five models were applied: (1 a null model (baseline modelwhere no predictors are introduced to the model; (2 the fixed model: where predictors used are the  covariate and the HDI; (3 the random model: where predictors used are  the covariate and Location ; (4 the mixed model: where predictors used are the covariate and the HDI I  ( fixed and the location( random; and (5 the random coefficient model: where predictors used are  the covariate ,  the HDI Index  and the location but produces different prediction equations that differ in slopes and intercepts. Models are compared based on information criterions. The random coefficient model produces the least criterion values and thus fits better than all previous ones. A comparison between the Random Coefficient

  20. What Happens to Integrated Product Development Models with Product/Service-System Approaches?

    DEFF Research Database (Denmark)

    Tan, Adrian; McAloone, Timothy Charles; Andreasen, Mogens Myrup

    2006-01-01

    Integrated Product Development (IPD) has traditionally focused on the development activities relating to physical technological artefacts. With the advent of business approaches for manufacturing firms based on providing customers the utility of integrated products and services – a term dubbed...... ‘product/service-systems (PSS)’ – companies need to extend their activities to include new dimensions of development. Within the paradigm of mass production and consumption, traditional product-oriented business strategies regarded physical technological artefacts (products) as the mediators of customer...... value. Value was based on the exchange of products between a providing company and a receiving customer. The more products the company could sell, the more revenue it generated. At the point of sale the ownership and responsibility of the product was transferred from company to customer. A customer...

  1. Developing a Model for ePortfolio Design: A Studio Approach

    Science.gov (United States)

    Carpenter, Russell; Apostel, Shawn; Hyndman, June Overton

    2012-01-01

    After developing and testing a model for integrative collaboration at Eastern Kentucky University's Noel Studio for Academic Creativity, we offer results that highlight the potential for peer review to significantly and positively impact the ePortfolio design process for students. The results of this classroom/studio collaboration suggest that…

  2. Effects of Energy Development on Hydrologic Response: a Multi-Scale Modeling Approach

    Science.gov (United States)

    Vithanage, J.; Miller, S. N.; Berendsen, M.; Caffrey, P. A.; Bellis, J.; Schuler, R.

    2013-12-01

    Potential impacts of energy development on surface hydrology in western Wyoming were assessed using spatially explicit hydrological models. Currently there are proposals to develop over 800 new oil and gas wells in the 218,000 acre-sized LaBarge development area that abuts the Wyoming Range and contributes runoff to the Upper Green River (approximately 1 well per 2 square miles). The intensity of development raises questions relating to impacts on the hydrological cycle, water quality, erosion and sedimentation. We developed landscape management scenarios relating to current disturbance and proposed actions put forth by the energy operators to provide inputs to spatially explicit hydrologic models. Differences between the scenarios were derived to quantify the changes and analyse the impacts to the project area. To perform this research, the Automated Watershed Assessment Tool (AGWA) was enhanced by adding different management practices suitable for the region, including the reclamation of disturbed lands over time. The AGWA interface was used to parameterize and execute two hydrologic models: the Soil and Water Assessment Tool (SWAT) and the KINEmatic Runoff and EROSion model (KINEROS2). We used freely available data including SSURGO soils, Multi-Resolution Landscape Consortium (MRLC) land cover, and 10m resolution terrain data to derive suitable initial parameters for the models. The SWAT model was manually calibrated using an innovative method at the monthly level; observed daily rainfall and temperature inputs were used as a function of elevation considering the local climate effects. Higher temporal calibration was not possible due to a lack of adequate climate and runoff data. The Nash Sutcliff efficiencies of two calibrated watersheds at the monthly scale exceeded 0.95. Results of the AGWA/SWAT simulations indicate a range of sensitivity to disturbance due to heterogeneous soil and terrain characteristics over a simulated time period of 10 years. The KINEROS

  3. New developments in modeling network constraints in techno-economic energy system expansion planning models. An overview of existing models and prospects for future approaches

    Energy Technology Data Exchange (ETDEWEB)

    Schoenfelder, Martin; Esser-Frey, Anke; Fichtner, Wolf [Karlsruher Institut fuer Technologie (KIT), Karlsruhe (Germany). Chair of Energy Economics; Schick, Michael; Heuveline, Vincent [Karlsruher Institut fuer Technologie (KIT), Karlsruhe (Germany). Engineering Mathematics and Computing Lab.; Leibfried, Thomas [Karlsruher Institut fuer Technologie (KIT), Karlsruhe (Germany). Inst. of Electric Energy Systems and High-Voltage Technology

    2012-03-15

    This paper is based on Groschke et al. (Z. Energiewirtsch. 33(1):14-22 2009) and continues the description of new developments in modeling network constraints in techno-economic energy system models with a focus on capacity expansion planning and a long-term time horizon. Based on the presentation of recent and future developments in the German energy system, current challenges in energy system modeling are derived. The following analysis of the state of research reveals a lack of high-precision load flow calculation in current energy system models with a long-term time horizon. Hence, this paper presents an outlook on a new mathematical approach, which already proved as a promising method to meet the challenges identified. (orig.)

  4. Multiple Perspective Approach for the Development of Information Systems Based on Advanced Mathematical Models

    DEFF Research Database (Denmark)

    Carugati, Andrea

    modeling (AMM) in scheduling and control systems. Advanced mathematical techniques are relatively new in scheduling and control systems, at least in real production situations, and therefore the project included the research of methods and tools for the development of these systems. Because of the novelty...... are grounded in an understanding of reality as a socially constructed phenomenon where the multiple perspectives of the actors involved (weltanschauung in the dissertation) are used as filters to understand the process of creation of the information system. Soft systems theory was used as the theoretical lens....... Keywords: Information systems development, information systems development methodology, advanced mathematical models, loosely coupled systems, distributed systems, knowledge exchange, boundary objects, systems theory, multiple perspectives, weltanschauung....

  5. Developing a New Integrated Model to improve the using of Classical Approach in Designing Management Information Systems

    OpenAIRE

    Mohammad M M Abu Omar; Khairul Anuar Abdullah

    2015-01-01

    Management information system (MIS) is used to solve management problems in the practical life, the designing and building of the management information systems is done by using one of the systems development methodologies. Classical approach is one of these methodologies which still suffer from some critical problems when it is used in designing and building the management information systems, it consumes more time and cost during its life cycle. This paper develops a new integrated model to...

  6. Development of a Subcell Based Modeling Approach for Modeling the Architecturally Dependent Impact Response of Triaxially Braided Polymer Matrix Composites

    Science.gov (United States)

    Sorini, Chris; Chattopadhyay, Aditi; Goldberg, Robert K.; Kohlman, Lee W.

    2016-01-01

    Understanding the high velocity impact response of polymer matrix composites with complex architectures is critical to many aerospace applications, including engine fan blade containment systems where the structure must be able to completely contain fan blades in the event of a blade-out. Despite the benefits offered by these materials, the complex nature of textile composites presents a significant challenge for the prediction of deformation and damage under both quasi-static and impact loading conditions. The relatively large mesoscale repeating unit cell (in comparison to the size of structural components) causes the material to behave like a structure rather than a homogeneous material. Impact experiments conducted at NASA Glenn Research Center have shown the damage patterns to be a function of the underlying material architecture. Traditional computational techniques that involve modeling these materials using smeared homogeneous, orthotropic material properties at the macroscale result in simulated damage patterns that are a function of the structural geometry, but not the material architecture. In order to preserve heterogeneity at the highest length scale in a robust yet computationally efficient manner, and capture the architecturally dependent damage patterns, a previously-developed subcell modeling approach where the braided composite unit cell is approximated as a series of four adjacent laminated composites is utilized. This work discusses the implementation of the subcell methodology into the commercial transient dynamic finite element code LS-DYNA (Livermore Software Technology Corp.). Verification and validation studies are also presented, including simulation of the tensile response of straight-sided and notched quasi-static coupons composed of a T700/PR520 triaxially braided [0deg/60deg/-60deg] composite. Based on the results of the verification and validation studies, advantages and limitations of the methodology as well as plans for future work

  7. Animal models of diabetic macrovascular complications: key players in the development of new therapeutic approaches.

    Science.gov (United States)

    Heinonen, Suvi E; Genové, Guillem; Bengtsson, Eva; Hübschle, Thomas; Åkesson, Lina; Hiss, Katrin; Benardeau, Agnes; Ylä-Herttuala, Seppo; Jönsson-Rylander, Ann-Cathrine; Gomez, Maria F

    2015-01-01

    Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic macrovascular complications (coronary heart disease, stroke, and peripheral vascular disease) and microvascular disorders leading to damage of the kidneys (nephropathy) and eyes (retinopathy). Based on the current trends, the rising prevalence of diabetes worldwide will lead to increased cardiovascular morbidity and mortality. Therefore, novel means to prevent and treat these complications are needed. Under the auspices of the IMI (Innovative Medicines Initiative), the SUMMIT (SUrrogate markers for Micro- and Macrovascular hard end points for Innovative diabetes Tools) consortium is working on the development of novel animal models that better replicate vascular complications of diabetes and on the characterization of the available models. In the past years, with the high level of genomic information available and more advanced molecular tools, a very large number of models has been created. Selecting the right model for a specific study is not a trivial task and will have an impact on the study results and their interpretation. This review gathers information on the available experimental animal models of diabetic macrovascular complications and evaluates their pros and cons for research purposes as well as for drug development.

  8. Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches

    Directory of Open Access Journals (Sweden)

    Suvi E. Heinonen

    2015-01-01

    Full Text Available Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic macrovascular complications (coronary heart disease, stroke, and peripheral vascular disease and microvascular disorders leading to damage of the kidneys (nephropathy and eyes (retinopathy. Based on the current trends, the rising prevalence of diabetes worldwide will lead to increased cardiovascular morbidity and mortality. Therefore, novel means to prevent and treat these complications are needed. Under the auspices of the IMI (Innovative Medicines Initiative, the SUMMIT (SUrrogate markers for Micro- and Macrovascular hard end points for Innovative diabetes Tools consortium is working on the development of novel animal models that better replicate vascular complications of diabetes and on the characterization of the available models. In the past years, with the high level of genomic information available and more advanced molecular tools, a very large number of models has been created. Selecting the right model for a specific study is not a trivial task and will have an impact on the study results and their interpretation. This review gathers information on the available experimental animal models of diabetic macrovascular complications and evaluates their pros and cons for research purposes as well as for drug development.

  9. Developing a Core Competency Model and Educational Framework for Primary Maternity Services: a national consensus approach.

    Science.gov (United States)

    Homer, Caroline S E; Griffiths, Marnie; Brodie, Pat M; Kildea, Sue; Curtin, Austin M; Ellwood, David A

    2012-09-01

    An appropriately educated and competent workforce is crucial to an effective health care system. The National Health Workforce Taskforce (now Health Workforce Australia) and the Maternity Services Inter-Jurisdictional Committee funded a project to develop Core Competencies and Educational Framework for Primary Maternity Services in Australia. These competencies recognise the interdisciplinary nature of maternity care in Australia where care is provided by general practitioners, obstetricians and midwives as well as other professionals. Key stakeholders from professional organisations and providers of services related to maternity care and consumers of services. A national consensus approach was undertaken using consultation processes with a Steering Committee, a wider Reference Group and public consultation. A national Core Competencies and Educational Framework for Primary Maternity Services in Australia was developed through an iterative process with a range of key stakeholders. There are a number of strategies that may assist in the integration of these into primary maternity service provider professional groups' education and practice. The Core Competencies and Educational Framework are based on an interprofessional approach to learning and primary maternity service practice. They have sought to value professional expertise and stimulate awareness and respect for the roles of all primary maternity service providers. The competencies and framework described in this paper are now a critical component of Australian maternity services as they are included in actions in the newly released National Maternity Services Plan and thus have relevance for all providers of Australian maternity services. Copyright © 2011 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  10. Business models for Serious Games developers - transition from a product centric to a service centric approach

    DEFF Research Database (Denmark)

    Hauge, Jannicke Baalsrud; Wiesner, Stefan; Sanchez, Rosa Garcia

    2014-01-01

    In the context of the serious games industry, up to now the most commonly used business models (BM) among developers representing small and medium enterprises (SMEs) consists in offering an individual product to the customer, based on tailored one-of a kind production. Such production has high co...... application fields of SG, before it presents two examples of a successful transition towards a service oriented BM within the same fields Based on this, it finally discusses the opportunities and the threats of using such BMs for SG developers....

  11. The West Central Alberta Woodland Caribou Landscape Plan: Using a Modeling Approach to Develop Alternative Scenarios

    Directory of Open Access Journals (Sweden)

    Anne Hubbs

    2011-09-01

    this modelling approach makes broad assumptions, it provides simple fundamental relationships that were useful in a multi-stakeholder team setting when evaluating the efficacy of different management strategies for the conservation of woodland caribou.

  12. Recent developments in predictive uncertainty assessment based on the model conditional processor approach

    Directory of Open Access Journals (Sweden)

    G. Coccia

    2011-10-01

    example, the data set provided by the NOAA's National Weather Service, within the DMIP 2 Project, allowed two physically based models, the TOPKAPI model and TETIS model, to be calibrated and a data driven model to be implemented using the Artificial Neural Network. The three model forecasts have been combined with the aim of reducing the PU and improving the probabilistic forecast taking advantage of the different capabilities of each model approach.

  13. Integrating health economics modeling in the product development cycle of medical devices: a Bayesian approach.

    Science.gov (United States)

    Vallejo-Torres, Laura; Steuten, Lotte M G; Buxton, Martin J; Girling, Alan J; Lilford, Richard J; Young, Terry

    2008-01-01

    Medical device companies are under growing pressure to provide health-economic evaluations of their products. Cost-effectiveness analyses are commonly undertaken as a one-off exercise at the late stage of development of new technologies; however, the benefits of an iterative use of economic evaluation during the development process of new products have been acknowledged in the literature. Furthermore, the use of Bayesian methods within health technology assessment has been shown to be of particular value in the dynamic framework of technology appraisal when new information becomes available in the life cycle of technologies. In this study, we set out a methodology to adapt these methods for their application to directly support investment decisions in a commercial setting from early stages of the development of new medical devices. Starting with relatively simple analysis from the very early development phase and proceeding to greater depth of analysis at later stages, a Bayesian approach facilitates the incorporation of all available evidence and would help companies to make better informed choices at each decision point.

  14. Improving clinical reality in chronic obstructive pulmonary disease economic modelling : development and validation of a micro-simulation approach.

    Science.gov (United States)

    Asukai, Yumi; Baldwin, Michael; Fonseca, Tiago; Gray, Alastair; Mungapen, Laura; Price, David

    2013-02-01

    Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible disease responsible for the deaths of 3 million people worldwide in 2005, and predicted to be the third leading cause of death worldwide by 2030. Many COPD models developed to date have followed a Markov structure, in which patients or populations can move between defined health states over successive time periods or cycles. In COPD, health states are typically based on disease severity defined solely by lung function, as described by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. These current modelling methods may restrict the ability to reflect the disease progression/clinical pathway or clinical practice. Given these limitations in previous COPD models, the authors aimed to develop a more flexible model that could improve on the description of the clinical disease pathway. The overall objective of this model was to inform the development of policies, guidelines or cost-effectiveness analyses. A second objective was to validate the model in relation to existing epidemiology studies of COPD. A patient simulation model was developed in Microsoft Excel™. The predictability of the model was tested by populating it with data from natural history of disease studies as well as with clinical trial data. Each patient moves through the model with demographic characteristics randomly generated from a set distribution. These characteristics determine the risk of clinical events occurring in the model. The validation with these studies found the model to have generally good predictive ability, yielding in this way a good degree of external validity. The micro-simulation model is a flexible approach for modelling COPD that allows consideration of complex COPD treatment pathways. The model was found to be generally robust in terms of predicting clinical outcomes of published studies when tested against other studies. It has significant potential as a tool for

  15. Enhancing the Lasso Approach for Developing a Survival Prediction Model Based on Gene Expression Data

    Directory of Open Access Journals (Sweden)

    Shuhei Kaneko

    2015-01-01

    Full Text Available In the past decade, researchers in oncology have sought to develop survival prediction models using gene expression data. The least absolute shrinkage and selection operator (lasso has been widely used to select genes that truly correlated with a patient’s survival. The lasso selects genes for prediction by shrinking a large number of coefficients of the candidate genes towards zero based on a tuning parameter that is often determined by a cross-validation (CV. However, this method can pass over (or fail to identify true positive genes (i.e., it identifies false negatives in certain instances, because the lasso tends to favor the development of a simple prediction model. Here, we attempt to monitor the identification of false negatives by developing a method for estimating the number of true positive (TP genes for a series of values of a tuning parameter that assumes a mixture distribution for the lasso estimates. Using our developed method, we performed a simulation study to examine its precision in estimating the number of TP genes. Additionally, we applied our method to a real gene expression dataset and found that it was able to identify genes correlated with survival that a CV method was unable to detect.

  16. The layered sensing operations center: a modeling and simulation approach to developing complex ISR networks

    Science.gov (United States)

    Curtis, Christopher; Lenzo, Matthew; McClure, Matthew; Preiss, Bruce

    2010-04-01

    In order to anticipate the constantly changing landscape of global warfare, the United States Air Force must acquire new capabilities in the field of Intelligence, Surveillance, and Reconnaissance (ISR). To meet this challenge, the Air Force Research Laboratory (AFRL) is developing a unifying construct of "Layered Sensing" which will provide military decision-makers at all levels with the timely, actionable, and trusted information necessary for complete battlespace awareness. Layered Sensing is characterized by the appropriate combination of sensors and platforms (including those for persistent sensing), infrastructure, and exploitation capabilities to enable this synergistic awareness. To achieve the Layered Sensing vision, AFRL is pursuing a Modeling & Simulation (M&S) strategy through the Layered Sensing Operations Center (LSOC). An experimental ISR system-of-systems test-bed, the LSOC integrates DoD standard simulation tools with commercial, off-the-shelf video game technology for rapid scenario development and visualization. These tools will help facilitate sensor management performance characterization, system development, and operator behavioral analysis. Flexible and cost-effective, the LSOC will implement a non-proprietary, open-architecture framework with well-defined interfaces. This framework will incentivize the transition of current ISR performance models to service-oriented software design for maximum re-use and consistency. This paper will present the LSOC's development and implementation thus far as well as a summary of lessons learned and future plans for the LSOC.

  17. Business models for Serious Games developers - transition from a product centric to a service centric approach

    DEFF Research Database (Denmark)

    Hauge, Jannicke Baalsrud; Wiesner, Stefan; Sanchez, Rosa Garcia

    2014-01-01

    In the context of the serious games industry, up to now the most commonly used business models (BM) among developers representing small and medium enterprises (SMEs) consists in offering an individual product to the customer, based on tailored one-of a kind production. Such production has high...... costs and low re-usability and leads to a long time-to-market. For an industry dealing with products highly dependent on technological advances, this implies high risks for failure and thus being put out of business. Consequently, an increasing number of Serious Games (SG) developers are struggling...... to survive. These trends are not specific for the SG development sector, but can actually be observed in several others, like software industry as well as the manufacturing industry, where a transition to less product-oriented BM can be observed. This article analyses first the current use of BM within two...

  18. DEVELOPMENT OF MATHEMATICAL MODELS FOR OPTIMAL PREVENTIVE MAINTENANCE POLICY IN A STEEL INDUSTRY : SIX SIGMA APPROACH

    Directory of Open Access Journals (Sweden)

    N. V. R. Naidu

    2011-09-01

    Full Text Available This paper deals with a critical evaluation of the Preventive Maintenance system in steel industry. This study helps in implementing Six Sigma solutions to reduce the down time of two critical machines i.e., Electric Arc Furnace (EAF and Billet Casting Machine (BCM. It is clear from the analysis of EAF and BCM respectively that, variations in output are quite possible because the machines output not only depend on maintenance time but also on several other variables. Further, the objective is to design a preventive maintenance programme on the same equipment situated in the plant using Six Sigma. The breakdown of these equipments could very well affect the production rate. For this, the mathematical models have been developed and these models are used to obtain the optimum preventive maintenance frequency for minimizing the down time and maximizing the profits.

  19. Development and evolution of caste dimorphism in honeybees - a modeling approach.

    Science.gov (United States)

    Leimar, Olof; Hartfelder, Klaus; Laubichler, Manfred D; Page, Robert E

    2012-12-01

    The difference in phenotypes of queens and workers is a hallmark of the highly eusocial insects. The caste dimorphism is often described as a switch-controlled polyphenism, in which environmental conditions decide an individual's caste. Using theoretical modeling and empirical data from honeybees, we show that there is no discrete larval developmental switch. Instead, a combination of larval developmental plasticity and nurse worker feeding behavior make up a colony-level social and physiological system that regulates development and produces the caste dimorphism. Discrete queen and worker phenotypes are the result of discrete feeding regimes imposed by nurses, whereas a range of experimental feeding regimes produces a continuous range of phenotypes. Worker ovariole numbers are reduced through feeding-regime-mediated reduction in juvenile hormone titers, involving reduced sugar in the larval food. Based on the mechanisms identified in our analysis, we propose a scenario of the evolutionary history of honeybee development and feeding regimes.

  20. Developing a simplified geographical information system approach to dilute lahar modelling for rapid hazard assessment

    Science.gov (United States)

    Darnell, A. R.; Phillips, J. C.; Barclay, J.; Herd, R. A.; Lovett, A. A.; Cole, P. D.

    2013-04-01

    In this study, we present a geographical information system (GIS)-based approach to enable the estimation of lahar features important to rapid hazard assessment (including flow routes, velocities and travel times). Our method represents a simplified first stage in extending the utility of widely used existing GIS-based inundation models, such as LAHARZ, to provide estimates of flow speeds. LAHARZ is used to determine the spatial distribution of a lahar of constant volume, and for a given cell in a GIS grid, a single-direction flow routing technique incorporating the effect of surface roughness directs the flow according to steepest descent. The speed of flow passing through a cell is determined from coupling the flow depth, change in elevation and roughness using Manning's formula, and in areas where there is little elevation difference, flow is routed to locally maximum increase in velocity. Application of this methodology to lahars on Montserrat, West Indies, yielded support for this GIS-based approach as a hazard assessment tool through tests on small volume (5,000-125,000 m3) dilute lahars (consistent with application of Manning's law). Dominant flow paths were mapped, and for the first time in this study area, velocities (magnitudes and spatial distribution) and average travel times were estimated for a range of lahar volumes. Flow depth approximations were also made using (modified) LAHARZ, and these refined the input to Manning's formula. Flow depths were verified within an order of magnitude by field observations, and velocity predictions were broadly consistent with proxy measurements and published data. Forecasts from this coupled method can operate on short to mid-term timescales for hazard management. The methodology has potential to provide a rapid preliminary hazard assessment in similar systems where data acquisition may be difficult.

  1. Chaste: A test-driven approach to software development for biological modelling

    KAUST Repository

    Pitt-Francis, Joe

    2009-12-01

    Chaste (\\'Cancer, heart and soft-tissue environment\\') is a software library and a set of test suites for computational simulations in the domain of biology. Current functionality has arisen from modelling in the fields of cancer, cardiac physiology and soft-tissue mechanics. It is released under the LGPL 2.1 licence. Chaste has been developed using agile programming methods. The project began in 2005 when it was reasoned that the modelling of a variety of physiological phenomena required both a generic mathematical modelling framework, and a generic computational/simulation framework. The Chaste project evolved from the Integrative Biology (IB) e-Science Project, an inter-institutional project aimed at developing a suitable IT infrastructure to support physiome-level computational modelling, with a primary focus on cardiac and cancer modelling. Program summary: Program title: Chaste. Catalogue identifier: AEFD_v1_0. Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEFD_v1_0.html. Program obtainable from: CPC Program Library, Queen\\'s University, Belfast, N. Ireland. Licensing provisions: LGPL 2.1. No. of lines in distributed program, including test data, etc.: 5 407 321. No. of bytes in distributed program, including test data, etc.: 42 004 554. Distribution format: tar.gz. Programming language: C++. Operating system: Unix. Has the code been vectorised or parallelized?: Yes. Parallelized using MPI. RAM:< 90   Megabytes for two of the scenarios described in Section 6 of the manuscript (Monodomain re-entry on a slab or Cylindrical crypt simulation). Up to 16 Gigabytes (distributed across processors) for full resolution bidomain cardiac simulation. Classification: 3. External routines: Boost, CodeSynthesis XSD, CxxTest, HDF5, METIS, MPI, PETSc, Triangle, Xerces. Nature of problem: Chaste may be used for solving coupled ODE and PDE systems arising from modelling biological systems. Use of Chaste in two application areas are described in this paper: cardiac

  2. The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling.

    Directory of Open Access Journals (Sweden)

    Arturo Araujo

    Full Text Available Many cancers are aneuploid. However, the precise role that chromosomal instability plays in the development of cancer and in the response of tumours to treatment is still hotly debated. Here, to explore this question from a theoretical standpoint we have developed an agent-based model of tissue homeostasis in which to test the likely effects of whole chromosome mis-segregation during cancer development. In stochastic simulations, chromosome mis-segregation events at cell division lead to the generation of a diverse population of aneuploid clones that over time exhibit hyperplastic growth. Significantly, the course of cancer evolution depends on genetic linkage, as the structure of chromosomes lost or gained through mis-segregation events and the level of genetic instability function in tandem to determine the trajectory of cancer evolution. As a result, simulated cancers differ in their level of genetic stability and in their growth rates. We used this system to investigate the consequences of these differences in tumour heterogeneity for anti-cancer therapies based on surgery and anti-mitotic drugs that selectively target proliferating cells. As expected, simulated treatments induce a transient delay in tumour growth, and reveal a significant difference in the efficacy of different therapy regimes in treating genetically stable and unstable tumours. These data support clinical observations in which a poor prognosis is correlated with a high level of chromosome mis-segregation. However, stochastic simulations run in parallel also exhibit a wide range of behaviours, and the response of individual simulations (equivalent to single tumours to anti-cancer therapy prove extremely variable. The model therefore highlights the difficulties of predicting the outcome of a given anti-cancer treatment, even in cases in which it is possible to determine the genotype of the entire set of cells within the developing tumour.

  3. Critical flow-storm approach to total maximum daily load(TMDL) development: an analytical conceptual model

    Institute of Scientific and Technical Information of China (English)

    Harry X.ZHANG; Shaw L.YU

    2008-01-01

    One of the key challenges in the total max-imum daily load (TMDL) development process is how to define the critical condition for a receiving water-body. The main concern in using a continuous simu-lation approach is the absence of any guarantee that the most critical condition will be captured during the selected representative hydrologic period, given the scar-city of long-term continuous data. The objectives of this paper are to clearly address the critical condition in the TMDL development process and to compare continu-ous and evEnt-based approaches in defining critical con-dition during TMDL development for a waterbody impacted by both point and nonpoint source pollution. A practical, event-based critical flow-storm (CFS) approach was developed to explicitly addresses the crit-ical condition as a combination of a low stream flow and a storm event of a selected magnitude, both having cer-tain frequencies of occurrence. This paper illustrated the CFS concept and provided its theoretical basis using a derived analytical conceptual model. The CFS approach clearly defined a critical condition, obtained reasonable results and could be considered as an alternative method in TMDL development.

  4. Development of statistical prediction models for Changma precipitation: An ensemble approach

    Science.gov (United States)

    Kim, Jin-Yong; Seo, Kyong-Hwan; Son, Jun-Hyeok; Ha, Kyung-Ja

    2017-05-01

    An ensemble statistical forecast scheme with a one-month lead is developed to predict year-to-year variations of Changma rainfall over the Korean peninsula. Spring sea surface temperature (SST) anomalies over the North Atlantic, the North Pacific and the tropical Pacific Ocean have been proposed as useful predictors in a previous study. Through a forward-stepwise regression method, four additional springtime predictors are selected: the northern Indian Ocean (NIO) SST, the North Atlantic SST change (NAC), the snow cover anomaly over the Eurasian continent (EUSC), and the western North Pacific outgoing longwave radiation anomaly (WNP (OLR)). Using these, three new prediction models are developed. A simple arithmetic ensemble mean produces much improved forecast skills compared to the original prediction model of Lee and Seo (2013). Skill scores measured by temporal correlation and MSSS (mean square error skill score) are improved by about 9% and 17%, respectively. The GMSS (Gerrity skill score) and hit rate based on a tercile prediction validation scheme are also enhanced by about 19% and 13%, respectively. The reversed NIO, reversed WNP (OLR), and reversed NAC are all related to the enhancement of a cyclonic circulation anomaly to the south or southwest of the Korean peninsula, which induces southeasterly moisture flux into the peninsula and increasing Changma precipitation. The EUSC predictor induces an enhancement of the Okhotsk Sea high downstream and thus strengthening of Changma front.

  5. Providing the meta-model of development of competency using the meta-ethnography approach: Part 2. Synthesis of the available competency development models

    Directory of Open Access Journals (Sweden)

    Somayeh Akbari Farmad

    2016-06-01

    Full Text Available Background and Purpose: Considering the importance and necessity of competency-based education at a global level and with respect to globalization and the requirement of minimum competencies in medical fields, medical education communities and organizations worldwide have tried to determine the competencies, present frameworks and education models to respond to be sure of the ability of all graduates. In the literature, we observed numerous competency development models that refer to the same issues with different terminologies. It seems that evaluation and synthesis of all these models can finally result in designing a comprehensive meta-model for competency development. Methods: Meta-ethnography is a useful method for synthesis of qualitative research that is used to develop models that interpret the results in several studies. Considering that the aim of this study is to ultimately provide a competency development meta-model, in the previous section of the study, the literature review was conducted to achieve competency development models. Models obtained through the search were studied in details, and the key concepts of the models and overarching concepts were extracted in this section, models’ concepts were reciprocally translated and the available competency development models were synthesized. Results: A presentation of the competency development meta-model and providing a redefinition of the Dreyfus brothers model. Conclusions: Given the importance of competency-based education at a global level and the need to review curricula and competency-based curriculum design, it is required to provide competency development as well as meta-model to be the basis for curriculum development. As there are a variety of competency development models available, in this study, it was tried to develop the curriculum using them. Keywords: Meta-ethnography, Competency development, Meta-model, Qualitative synthesis

  6. Development of a censored modelling approach for stochastic estimation of rainfall extremes at fine temporal scales

    Science.gov (United States)

    Cross, David; Onof, Christian; Bernardara, Pietro

    2016-04-01

    With the COP21 drawing to a close in December 2015, storms Desmond, Eva and Frank which swept across the UK and Ireland causing widespread flooding and devastation have acted as a timely reminder of the need for reliable estimation of rainfall extremes in a changing climate. The frequency and intensity of rainfall extremes are predicted to increase in the UK under anthropogenic climate change, and it is notable that the UK's 24 hour rainfall record of 316mm set in Seathwaite, Cumbria in 2009 was broken on the 5 December 2015 with 341mm by storm Desmond at Honister Pass also in Cumbria. Immediate analysis of the latter by the Centre for Ecology and Hydrology (UK) on the 8 December 2015 estimated that this is approximately equivalent to a 1300 year return period event (Centre for Ecology & Hydrology, 2015). Rainfall extremes are typically estimated using extreme value analysis and intensity duration frequency curves. This study investigates the potential for using stochastic rainfall simulation with mechanistic rectangular pulse models for estimation of extreme rainfall. These models have been used since the late 1980s to generate synthetic rainfall time-series at point locations for scenario analysis in hydrological studies and climate impact assessment at the catchment scale. Routinely they are calibrated to the full historical hyetograph and used for continuous simulation. However, their extremal performance is variable with a tendency to underestimate short duration (hourly and sub-hourly) rainfall extremes which are often associated with heavy convective rainfall in temporal climates such as the UK. Focussing on hourly and sub-hourly rainfall, a censored modelling approach is proposed in which rainfall below a low threshold is set to zero prior to model calibration. It is hypothesised that synthetic rainfall time-series are poor at estimating extremes because the majority of the training data are not representative of the climatic conditions which give rise to

  7. Remittance and economic development: Evidence from Bangladesh using unrestricted error correction model and Engle-Granger cointegration approach

    Directory of Open Access Journals (Sweden)

    Shimul Shafiun N

    2013-04-01

    Full Text Available Remittance is one of the popular issues in the development economics. This paper attempted at finding the relationship between remittance flow and economic development using time series data of 1976-2007. The two modern time series econometric approaches- bound testing Autoregressive Distributed Lag Models or Unrestricted Error Correction Model (UECM and Engel Granger two step procedure for co-integration test- were executed and this study found that remittance was not significantly affecting the GDP per capita both in the short and long run although the foreign direct investment was found significant in the short but not in the long run. The study suggested adopting appropriate steps so that these can be used as a contributor to the economic development.

  8. iSemServ: A model-driven approach to developing semantic web services

    CSIR Research Space (South Africa)

    Mtsweni, J

    2014-07-01

    Full Text Available using description languages of choice, such as Web Ontology Language for Services (OWL-S) and Web Application Description Language (WADL). A design science research methodology was employed in conducting the study. The suggested approach was practically...

  9. Elements of a flexible approach for conceptual hydrological modeling: 1. Motivation and theoretical development

    NARCIS (Netherlands)

    Fenicia, F.; Kavetski, D.; Savenije, H.H.G.

    2011-01-01

    This paper introduces a flexible framework for conceptual hydrological modeling, with two related objectives: (1) generalize and systematize the currently fragmented field of conceptual models and (2) provide a robust platform for understanding and modeling hydrological systems. In contrast to curre

  10. A stepwise model for simulation-based curriculum development for clinical skills, a modification of the six-step approach.

    Science.gov (United States)

    Khamis, Nehal N; Satava, Richard M; Alnassar, Sami A; Kern, David E

    2016-01-01

    Despite the rapid growth in the use of simulation in health professions education, courses vary considerably in quality. Many do not integrate efficiently into an overall school/program curriculum or conform to academic accreditation requirements. Moreover, some of the guidelines for simulation design are specialty specific. We designed a model that integrates best practices for effective simulation-based training and a modification of Kern et al.'s 6-step approach for curriculum development. We invited international simulation and health professions education experts to complete a questionnaire evaluating the model. We reviewed comments and suggested modifications from respondents and reached consensus on a revised version of the model. We recruited 17 simulation and education experts. They expressed a consensus on the seven proposed curricular steps: problem identification and general needs assessment, targeted needs assessment, goals and objectives, educational strategies, individual assessment/feedback, program evaluation, and implementation. We received several suggestions for descriptors that applied the steps to simulation, leading to some revisions in the model. We have developed a model that integrates principles of curriculum development and simulation design that is applicable across specialties. Its use could lead to high-quality simulation courses that integrate efficiently into an overall curriculum.

  11. The New Approach : A New Model to Develop a Plan Proposal. North Strathfield, Australia

    OpenAIRE

    Klåvus, Malin; Lennartsson, Elenor

    2009-01-01

    This diploma work is carried through in Australia on a site in North Strathfield in the Sydney region. The whole work is built up around the idea to do four plan proposals that are optimized from different aspects. These aspects are chosen because we believe they are the most important issues in planning. Our four approaches are transportation, commercial, environmental and social aspects which will be joined into one final plan proposal. For each approach we have chosen what to focus on to d...

  12. Child Development Laboratory Schools as Generators of Knowledge in Early Childhood Education: New Models and Approaches

    Science.gov (United States)

    McBride, Brent A.; Groves, Melissa; Barbour, Nancy; Horm, Diane; Stremmel, Andrew; Lash, Martha; Bersani, Carol; Ratekin, Cynthia; Moran, James; Elicker, James; Toussaint, Susan

    2012-01-01

    Research Findings: University-based child development laboratory programs have a long and rich history of supporting teaching, research, and outreach activities in the child development/early childhood education fields. Although these programs were originally developed in order to conduct research on children and families to inform policy and…

  13. Child Development Laboratory Schools as Generators of Knowledge in Early Childhood Education: New Models and Approaches

    Science.gov (United States)

    McBride, Brent A.; Groves, Melissa; Barbour, Nancy; Horm, Diane; Stremmel, Andrew; Lash, Martha; Bersani, Carol; Ratekin, Cynthia; Moran, James; Elicker, James; Toussaint, Susan

    2012-01-01

    Research Findings: University-based child development laboratory programs have a long and rich history of supporting teaching, research, and outreach activities in the child development/early childhood education fields. Although these programs were originally developed in order to conduct research on children and families to inform policy and…

  14. Strategy for a numerical Rock Mechanics Site Descriptive Model. Further development of the theoretical/numerical approach

    Energy Technology Data Exchange (ETDEWEB)

    Olofsson, Isabelle; Fredriksson, Anders [Golder Associates AB, Stockholm (Sweden)

    2005-05-15

    The Swedish Nuclear and Fuel Management Company (SKB) is conducting Preliminary Site Investigations at two different locations in Sweden in order to study the possibility of a Deep Repository for spent fuel. In the frame of these Site Investigations, Site Descriptive Models are achieved. These products are the result of an interaction of several disciplines such as geology, hydrogeology, and meteorology. The Rock Mechanics Site Descriptive Model constitutes one of these models. Before the start of the Site Investigations a numerical method using Discrete Fracture Network (DFN) models and the 2D numerical software UDEC was developed. Numerical simulations were the tool chosen for applying the theoretical approach for characterising the mechanical rock mass properties. Some shortcomings were identified when developing the methodology. Their impacts on the modelling (in term of time and quality assurance of results) were estimated to be so important that the improvement of the methodology with another numerical tool was investigated. The theoretical approach is still based on DFN models but the numerical software used is 3DEC. The main assets of the programme compared to UDEC are an optimised algorithm for the generation of fractures in the model and for the assignment of mechanical fracture properties. Due to some numerical constraints the test conditions were set-up in order to simulate 2D plane strain tests. Numerical simulations were conducted on the same data set as used previously for the UDEC modelling in order to estimate and validate the results from the new methodology. A real 3D simulation was also conducted in order to assess the effect of the '2D' conditions in the 3DEC model. Based on the quality of the results it was decided to update the theoretical model and introduce the new methodology based on DFN models and 3DEC simulations for the establishment of the Rock Mechanics Site Descriptive Model. By separating the spatial variability into two

  15. Structural modelling of ASR-affected concrete: The approach developed in the PAT-ASR project

    NARCIS (Netherlands)

    Esposito, R.; Hendriks, M.A.N.

    2013-01-01

    The Alkali-Silica Reaction is a harmful reaction which can compromise the integrity and capacity of concrete structures. Due to its nature, a multiscale material model has been chosen to perform structural analyses. The model aims to couple the chemical and mechanical effects in order to characteriz

  16. Elements of a flexible approach for conceptual hydrological modeling: 1. Motivation and theoretical development

    Science.gov (United States)

    Fenicia, Fabrizio; Kavetski, Dmitri; Savenije, Hubert H. G.

    2011-11-01

    This paper introduces a flexible framework for conceptual hydrological modeling, with two related objectives: (1) generalize and systematize the currently fragmented field of conceptual models and (2) provide a robust platform for understanding and modeling hydrological systems. In contrast to currently dominant "fixed" model applications, the flexible framework proposed here allows the hydrologist to hypothesize, build, and test different model structures using combinations of generic components. This is particularly useful for conceptual modeling at the catchment scale, where limitations in process understanding and data availability remain major research and operational challenges. The formulation of the model architecture and individual components to represent distinct aspects of catchment-scale function, such as storage, release, and transmission of water, is discussed. Several numerical strategies for implementing the model equations within a computationally robust framework are also presented. In the companion paper, the potential of the flexible framework is examined with respect to supporting more systematic and stringent hypothesis testing, for characterizing catchment diversity, and, more generally, for aiding progress toward more unified hydrological theory at the catchment scale.

  17. Conceptual model development for landscape management in the mountains of the Indian Himalayan region: an approach for sustainable socio-ecological development

    Directory of Open Access Journals (Sweden)

    Sunil Nautiyal

    2010-09-01

    Full Text Available This study aims at presenting a conceptual model for landscape management in the Himalayan region of India, using quantitative/mathematical approach. Keeping in view the requirement, (based on fifteen years empirical field work in the Himalayan region and as well as literature survey the MODAM (Multiple Objectives Decision Support Tools for Landscape Management model along with linear programming approach was adopted with a view to presenting additional methodological perspectives on interdisciplinary landscape research. The work has stemmed out from the original research contribution, which tries to integrate interdisciplinary research planning with landscape management related research in the Himalayan region. This biodiversity hotspot has relatively high complexity in terms of sustainable socioeconomic development vis a vis conservation and management of the resources. The concepts and insights presented in this article will provide the basis for a discussion, on decisionmaking issues among multidisciplinary experts with regard to sustainable socioecological development within complex environments.

  18. Towards a Multi-criteria Development Distribution Model: An Analysis of Existing Task Distribution Approaches

    OpenAIRE

    2014-01-01

    Distributing development tasks in the context of global software development bears both many risks and many opportunities. Nowadays, distributed development is often driven by only a few factors or even just a single factor such as workforce costs. Risks and other relevant factors such as workforce capabilities, the innovation potential of different regions, or cultural factors are often not recognized sufficiently. This could be improved by using empirically-based multi-criteria distribution...

  19. A Model-Based Approach for Planning and Developing a Family of Technology-Based Products

    OpenAIRE

    V. Krishnan; Rahul Singh; Devanath Tirupati

    1999-01-01

    In this paper, we address the product-family design problem of a firm in a market in which customers choose products based on some measure of product performance. By developing products as a family, the firm can reduce the cost of developing individual product variants due to the reuse of a common product platform. Such a platform, designed in an aggregate-planning phase that precedes the development of individual product variants, is itself expensive to develop. Hence, its costs must be weig...

  20. A Case of Energy and Ecology System Development and a New Approach to System Dynamics Modeling

    Institute of Scientific and Technical Information of China (English)

    JIA Ren-an; YANG Bo; WU Fu-ming; HU Ling

    2002-01-01

    This paper uses SD rate variable fundamental in-tree modeling, SD branch-vector determinant method and systems archetype as tools to understand the structure and functions of energy and ecology system in Wangheqiu.

  1. Proposal of a Novel Approach to Developing Material Models for Micro-scale Composites Based on Testing and Modeling of Macro-scale Composites

    Energy Technology Data Exchange (ETDEWEB)

    Siranosian, Antranik Antonio [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Schembri, Philip Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Luscher, Darby Jon [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-04-20

    The Los Alamos National Laboratory's Weapon Systems Engineering division's Advanced Engineering Analysis group employs material constitutive models of composites for use in simulations of components and assemblies of interest. Experimental characterization, modeling and prediction of the macro-scale (i.e. continuum) behaviors of these composite materials is generally difficult because they exhibit nonlinear behaviors on the meso- (e.g. micro-) and macro-scales. Furthermore, it can be difficult to measure and model the mechanical responses of the individual constituents and constituent interactions in the composites of interest. Current efforts to model such composite materials rely on semi-empirical models in which meso-scale properties are inferred from continuum level testing and modeling. The proposed approach involves removing the difficulties of interrogating and characterizing micro-scale behaviors by scaling-up the problem to work with macro-scale composites, with the intention of developing testing and modeling capabilities that will be applicable to the mesoscale. This approach assumes that the physical mechanisms governing the responses of the composites on the meso-scale are reproducible on the macro-scale. Working on the macro-scale simplifies the quantification of composite constituents and constituent interactions so that efforts can be focused on developing material models and the testing techniques needed for calibration and validation. Other benefits to working with macro-scale composites include the ability to engineer and manufacture—potentially using additive manufacturing techniques—composites that will support the application of advanced measurement techniques such as digital volume correlation and three-dimensional computed tomography imaging, which would aid in observing and quantifying complex behaviors that are exhibited in the macro-scale composites of interest. Ultimately, the goal of this new approach is to develop a meso

  2. A Model of e-Learning by Constructivism Approach Using Problem-Based Learning to Develop Thinking Skills for Students in Rajaghat University

    Science.gov (United States)

    Shutimarrungson, Werayut; Pumipuntu, Sangkom; Noirid, Surachet

    2014-01-01

    This research aimed to develop a model of e-learning by using Problem-Based Learning--PBL to develop thinking skills for students in Rajabhat University. The research is divided into three phases through the e-learning model via PBL with Constructivism approach as follows: Phase 1 was to study characteristics and factors through the model to…

  3. Innovation in Integrated Chemical Product-Process Design - Development through a Model-based Systems Approach

    DEFF Research Database (Denmark)

    Conte, Elisa

    in the design and verification of such products. The objective of this project is to tackle the problem with computer-aided tools at first, using experimental techniques for final testing, evaluation and amendment. In this way, time and resources can be spared and the product can reach the market faster...... in which experiments are planned and a third stage in which experiments are performed to validate the final product formula. The main focus of the project is on the development of the computer-aided stage of the methodology described above. The methodology considers two different scenarios: the design...... systems are proposed, and the associated computer programs are also developed; the computer-aided stage of the methodology for formulation design and verification is implemented as an option in the software the ‘virtual Product-Process Design laboratory’. Four case studies have been developed...

  4. Curriculum information models in health professions education in Australia: an innovative approach to efficient curriculum design, development, and maintenance.

    Science.gov (United States)

    Kruger, Estie; Tennant, Marc

    2012-03-01

    Over the last decade, there has been a significant increase in attention to the overall accountability of higher education in Australia, and this is expected to continue. Increased accountability has led to the need for more explicitly documented curricula. The curricula from ten health-related disciplines developed over the last five years in Australia were the basis of this study. Curriculum information modeling is an approach that allows for the dynamic nature of curricula since elements and their linkages can be moved about and reconnected into meaningful patterns. In addition, the models give disciplines and institutions the ability to effectively monitor curricula and draw comparisons in a more unified manner. Curriculum information models are an efficient innovation in the design and management of curricula in higher education and particularly in the health care disciplines. They rest on the principles of reusable elements and linkages independent of content that were first used in the design, construction, and maintenance of buildings. The translation of this approach to the higher education sector provides a higher level of interoperability of resources and a clearer pathway for content design within a curriculum.

  5. Developing Dynamic Reference Models and a Decision Support Framework for Southeastern Ecosystems: An Integrated Approach

    Science.gov (United States)

    2015-06-01

    rates (e.g., see Section 3.5). This is important to note, however, because this assumption could automatically reduce the accuracy of ST-SIM model...polyglottos Orchard Oriole Icterus spurius Pine Warbler Setophaga pinus Pileated Woodpecker Dryocopus pileatus Purple Martin Progne subis Red-bellied...DSS. In addition to facilitating the processing of the field data, the DSS automatically generates standardized and accessible reports that allow

  6. Modelling the Dynamics of Agricultural Development: A Process Approach. The case of Koutiala (Mali)

    NARCIS (Netherlands)

    Struif Bontkes, T.

    1999-01-01

    Introduction

    Sustainability of agricultural production and food supply is threatened in many developing countries by human population growth. The increasing food requirement forces the population to extend the cultivated areas to less fertile areas, often without taking sufficient measures t

  7. Modelling the dynamics of agricultural development : a process approach : the case of Koutiala (Mali)

    NARCIS (Netherlands)

    Struif Bontkes, T.

    1999-01-01

    Introduction

    Sustainability of agricultural production and food supply is threatened in many developing countries by human population growth. The increasing food requirement forces the population to extend the cultivated areas to less fertile areas, often without taking

  8. Model-based Rational and Systematic Protein Purification Process Development: A Knowledge-based Approach

    NARCIS (Netherlands)

    Kungah Nfor, B.

    2011-01-01

    The increasing market and regulatory (quality and safety) demands on therapeutic proteins calls for radical improvement in their manufacturing processes. Addressing these challenges requires the adoption of strategies and tools that enable faster and more efficient process development. This thesis i

  9. Using the dual-level modeling approach to developing applications in the pervasive healthcare environment

    NARCIS (Netherlands)

    Cardoso de Moraes, João Luís; Lopes de Souza, Wanderley; Ferreira Pires, Luis; Cavalini, Luciana Tricai; Prado, do Antonio Francisco

    2013-01-01

    Health information technology is the area of IT involving the design, development, creation, use and maintenance of information systems for the healthcare industry. Automated and interoperable healthcare information systems are expected to lower costs, improve efficiency and reduce error, while also

  10. Integrating health economics modeling in the product development cycle of medical devices: A Bayesian approach

    NARCIS (Netherlands)

    Vallejo-Torres, Laura; Steuten, Lotte Maria Gertruda; Buxton, Martin J.; Girling, Alan J.; Lilford, Richard J.; Young, Terry

    2008-01-01

    Objectives: Medical device companies are under growing pressure to provide health-economic evaluations of their products. Cost-effectiveness analyses are commonly undertaken as a one-off exercise at the late stage of development of new technologies; however, the benefits of an iterative use of

  11. Is Model-Based Development a Favorable Approach for Complex and Safety-Critical Computer Systems on Commercial Aircraft?

    Science.gov (United States)

    Torres-Pomales, Wilfredo

    2014-01-01

    A system is safety-critical if its failure can endanger human life or cause significant damage to property or the environment. State-of-the-art computer systems on commercial aircraft are highly complex, software-intensive, functionally integrated, and network-centric systems of systems. Ensuring that such systems are safe and comply with existing safety regulations is costly and time-consuming as the level of rigor in the development process, especially the validation and verification activities, is determined by considerations of system complexity and safety criticality. A significant degree of care and deep insight into the operational principles of these systems is required to ensure adequate coverage of all design implications relevant to system safety. Model-based development methodologies, methods, tools, and techniques facilitate collaboration and enable the use of common design artifacts among groups dealing with different aspects of the development of a system. This paper examines the application of model-based development to complex and safety-critical aircraft computer systems. Benefits and detriments are identified and an overall assessment of the approach is given.

  12. Strategy for a Rock Mechanics Site Descriptive Model. Development and testing of an approach to modelling the state of stress

    Energy Technology Data Exchange (ETDEWEB)

    Hakami, Eva; Hakami, Hossein [Itasca Geomekanik AB, Solna (Sweden); Cosgrove, John [Imperial College of Science and Technology, London (United Kingdom)

    2002-05-01

    The overall objective of this project has been to develop, test and establish a method for creating a Rock Mechanics Site Descriptive Model for a site considered in the site investigation programme. The work was divided into three parts, the empirical and theoretical 'property models' and the 'stress model'. The work on the stress model is presented in this report. The work consisted of i) a literature review about geological factors controlling in situ stress and a review about the use of numerical models for this subject, ii) the development of recommendations on the methodology to be applied during a site investigation and iii) the Test Case exercise, where the suggested methods were tested. The main mechanism controlling the in situ stress magnitudes in Sweden is plate tectonics causing the stress field to show similarities in most parts of north-western Europe, having a NW-SE trend of the maximum principal stress. The orientation of the stress field is largely determined by the relative movements by the plates. However, the stress orientation may also be influenced by the presence of large regional weak zones, such as the Tornquist deformation zone that lies between Sweden and Denmark. The strike of the Tornquist deformation zone is parallel to the maximum principal stress as observed in central and southern Sweden. The magnitude of the stress is more difficult to estimate, but the general pattern is an increase in magnitude with depth, at least for the upper kilometres. To determine the stress magnitude at a certain site and depth, with reasonable certainty, stress measurement should be used. A methodology for building a stress model has been proposed. It involves different steps starting with a preliminary stress estimation, followed by steps for interpreting site-specific information. If the stress pattern and structural geology of the site are complex, including major fracture zones intersecting the area, numerical analyses of the

  13. Business models for Serious Games developers - transition from a product centric to a service centric approach.

    Directory of Open Access Journals (Sweden)

    Jannicke Baalsrud Hauge

    2014-02-01

    Full Text Available In the context of the serious games industry, up to now the most commonly used BM among developers representing SMEs consists in offering an individual product to the customer, based on tailored one-of a kind production. Such production has high costs and low re-usability and leads to a long time-to-market. For an industry dealing with products highly dependent on technological advances, this implies high risks for failure and thus being put out of business. Consequently, an increasing number of Serious Games developers are struggling to survive. These trends are not specific for the SG development sector, but can actually be observed in several others, like software industry as well as the manufacturing industry, where a transition to less product-oriented BM can be observed. This article is based on an analysis of cases studies to outline how such a transition might be possible also within serious game industry, but also to discuss the threats and opportunities of the transition, both based on case studies as well as on comparison with experiences in other industries

  14. What counts in preschool number knowledge? A Bayes factor analytic approach toward theoretical model development.

    Science.gov (United States)

    Mou, Yi; Berteletti, Ilaria; Hyde, Daniel C

    2017-09-06

    Preschool children vary tremendously in their numerical knowledge, and these individual differences strongly predict later mathematics achievement. To better understand the sources of these individual differences, we measured a variety of cognitive and linguistic abilities motivated by previous literature to be important and then analyzed which combination of these variables best explained individual differences in actual number knowledge. Through various data-driven Bayesian model comparison and selection strategies on competing multiple regression models, our analyses identified five variables of unique importance to explaining individual differences in preschool children's symbolic number knowledge: knowledge of the count list, nonverbal approximate numerical ability, working memory, executive conflict processing, and knowledge of letters and words. Furthermore, our analyses revealed that knowledge of the count list, likely a proxy for explicit practice or experience with numbers, and nonverbal approximate numerical ability were much more important to explaining individual differences in number knowledge than general cognitive and language abilities. These findings suggest that children use a diverse set of number-specific, general cognitive, and language abilities to learn about symbolic numbers, but the contribution of number-specific abilities may overshadow that of more general cognitive abilities in the learning process. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Developing a nutrient pollution model to assist policy makers by using a meso-scale Minimum Information Requirement (MIR approach

    Directory of Open Access Journals (Sweden)

    R. Adams

    2014-09-01

    Full Text Available A model for simulating runoff pathways and water quality fluxes has been developed using the Minimum Information (MIR approach. The model, the Catchment Runoff Attenuation Tool (CRAFT is applicable to meso-scale catchments which focusses primarily on hydrological pathways that mobilise nutrients. Hence CRAFT can be used investigate the impact of management intervention strategies designed to reduce the loads of nutrients into receiving watercourses. The model can help policy makers, for example in Europe, meet water quality targets and consider methods to obtain "good" ecological status. A case study of the 414 km2 Frome catchment, Dorset UK, has been described here as an application of the CRAFT model. The model was primarily calibrated on ten years of weekly data to reproduce the observed flows and nutrient (nitrate nitrogen – N – and phosphorus – P concentrations. Also data from two years of sub-daily high resolution monitoring at the same site were also analysed. These data highlighted some additional signals in the nutrient flux, particularly of soluble reactive phosphorus, which were not observable in the weekly data. This analysis has prompted the choice of using a daily timestep for this meso-scale modelling study as the minimum information requirement. A management intervention scenario was also run to show how the model can support catchment managers to investigate how reducing the concentrations of N and P in the various flow pathways. This scale appropriate modelling tool can help policy makers consider a range of strategies to to meet the European Union (EU water quality targets for this type of catchment.

  16. Global land model development: time to shift from a plant functional type to a plant functional trait approach

    Science.gov (United States)

    Reich, P. B.; Butler, E. E.

    2015-12-01

    This project will advance global land models by shifting from the current plant functional type approach to one that better utilizes what is known about the importance and variability of plant traits, within a framework of simultaneously improving fundamental physiological relations that are at the core of model carbon cycling algorithms. Existing models represent the global distribution of vegetation types using the Plant Functional Typeconcept. Plant Functional Types are classes of plant species with similar evolutionary and life history withpresumably similar responses to environmental conditions like CO2, water and nutrient availability. Fixedproperties for each Plant Functional Type are specified through a collection of physiological parameters, or traits.These traits, mostly physiological in nature (e.g., leaf nitrogen and longevity) are used in model algorithms to estimate ecosystem properties and/or drive calculated process rates. In most models, 5 to 15 functional types represent terrestrial vegetation; in essence, they assume there are a total of only 5 to 15 different kinds of plants on the entire globe. This assumption of constant plant traits captured within the functional type concept has serious limitations, as a single set of traits does not reflect trait variation observed within and between species and communities. While this simplification was necessary decades past, substantial improvement is now possible. Rather than assigning a small number of constant parameter values to all grid cells in a model, procedures will be developed that predict a frequency distribution of values for any given grid cell. Thus, the mean and variance, and how these change with time, will inform and improve model performance. The trait-based approach will improve land modeling by (1) incorporating patterns and heterogeneity of traits into model parameterization, thus evolving away from a framework that considers large areas of vegetation to have near identical trait

  17. Development of a novel in silico model of zeta potential for metal oxide nanoparticles: a nano-QSPR approach

    Science.gov (United States)

    Wyrzykowska, Ewelina; Mikolajczyk, Alicja; Sikorska, Celina; Puzyn, Tomasz

    2016-11-01

    Once released into the aquatic environment, nanoparticles (NPs) are expected to interact (e.g. dissolve, agglomerate/aggregate, settle), with important consequences for NP fate and toxicity. A clear understanding of how internal and environmental factors influence the NP toxicity and fate in the environment is still in its infancy. In this study, a quantitative structure-property relationship (QSPR) approach was employed to systematically explore factors that affect surface charge (zeta potential) under environmentally realistic conditions. The nano-QSPR model developed with multiple linear regression (MLR) was characterized by high robustness ({{{Q}}{{2}}}{{CV}}=0.90) and external predictivity ({{{Q}}{{2}}}{{EXT}}=0.93). The results clearly showed that zeta potential values varied markedly as functions of the ionic radius of the metal atom in the metal oxides, confirming that agglomeration and the extent of release of free MexOy largely depend on their intrinsic properties. A developed nano-QSPR model was successfully applied to predict zeta potential in an ionized solution of NPs for which experimentally determined values of response have been unavailable. Hence, the application of our model is possible when the values of zeta potential in the ionized solution for metal oxide nanoparticles are undetermined, without the necessity of performing more time consuming and expensive experiments. We believe that our studies will be helpful in predicting the conditions under which MexOy is likely to become problematic for the environment and human health.

  18. Developing a regional scale approach for modelling the impacts of fertiliser regime on N2O emissions in Ireland

    Science.gov (United States)

    Zimmermann, Jesko; Jones, Michael

    2016-04-01

    error (RMSE urease inhibitors. The results suggest that modelling changes in fertiliser regime on a large scale may require a multi-model approach to assure best performance. Ultimately, the research aims to develop a GIS based platform to apply such an approach on a regional scale.

  19. Developing Novel Therapeutic Approaches in Small Cell Lung Carcinoma Using Genetically Engineered Mouse Models and Human Circulating Tumor Cells

    Science.gov (United States)

    2015-10-01

    Using Genetically Engineered Mouse Models and Human Circulating Tumor Cells PRINCIPAL INVESTIGATOR: Jeffrey Engelman MD PhD CONTRACTING...SUBTITLE Developiing Novel Therapeutic Approaches in Small Cell Lung 5a. CONTRACT NUMBER Carcinoma Using Genetically Engineered Mouse Models and 5b...biomarkers. 15. SUBJECT TERMS Small cell lung cancer (SCLC), Genetically engineered mouse model (GEMM), BH3 mimetic, TORC inhibitor, Apoptosis

  20. Development of a population of cancer cells: Observation and modeling by a Mixed Spatial Evolutionary Games approach.

    Science.gov (United States)

    Świerniak, Andrzej; Krześlak, Michał; Student, Sebastian; Rzeszowska-Wolny, Joanna

    2016-09-21

    Living cells, like whole living organisms during evolution, communicate with their neighbors, interact with the environment, divide, change their phenotypes, and eventually die. The development of specific ways of communication (through signaling molecules and receptors) allows some cellular subpopulations to survive better, to coordinate their physiological status, and during embryonal development to create tissues and organs or in some conditions to become tumors. Populations of cells cultured in vitro interact similarly, also competing for space and nutrients and stimulating each other to better survive or to die. The results of these intercellular interactions of different types seem to be good examples of biological evolutionary games, and have been the subjects of simulations by the methods of evolutionary game theory where individual cells are treated as players. Here we present examples of intercellular contacts in a population of living human cancer HeLa cells cultured in vitro and propose an evolutionary game theory approach to model the development of such populations. We propose a new technique termed Mixed Spatial Evolutionary Games (MSEG) which are played on multiple lattices corresponding to the possible cellular phenotypes which gives the possibility of simulating and investigating the effects of heterogeneity at the cellular level in addition to the population level. Analyses performed with MSEG suggested different ways in which cellular populations develop in the case of cells communicating directly and through factors released to the environment.

  1. Using the Dynamic Model to develop an evidence-based and theory-driven approach to school improvement

    NARCIS (Netherlands)

    Creemers, B.P.M.; Kyriakides, L.

    2010-01-01

    This paper refers to a dynamic perspective of educational effectiveness and improvement stressing the importance of using an evidence-based and theory-driven approach. Specifically, an approach to school improvement based on the dynamic model of educational effectiveness is offered. The recommended

  2. Modelling river dune development

    NARCIS (Netherlands)

    Paarlberg, Andries; Weerts, H.J.T.; Dohmen-Janssen, Catarine M.; Ritsema, I.L; Hulscher, Suzanne J.M.H.; van Os, A.G.; Termes, A.P.P.

    2005-01-01

    Since river dunes influence flow resistance, predictions of dune dimensions are required to make accurate water level predictions. A model approach to simulate developing river dunes is presented. The model is set-up to be appropriate, i.e. as simple as possible, but with sufficient accuracy for

  3. An Evaluation of the Developmental Designs Approach and Professional Development Model on Classroom Management in 22 Middle Schools in a Large, Midwestern School District

    Science.gov (United States)

    Hough, David L.

    2011-01-01

    This study presents findings from an evaluation of the Developmental Designs classroom management approach and professional development model during its first year of implementation across 22 middle schools in a large, Midwestern school district. The impact of this professional development model on teaching and learning as related to participants'…

  4. Development of a modeling approach to predict ash formation during co-firing of coal and biomass

    Energy Technology Data Exchange (ETDEWEB)

    Doshi, V. [School of Engineering, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor (Malaysia); Vuthaluru, H.B. [Curtin University of Technology, Kent Street, Bentley 6104, Perth, Western Australia (Australia); Korbee, R. [HRL Technology, Ipswich, Queensland (Australia); Kiel, J.H.A. [ECN Biomass, Coal and Environmental Research, P.O. Box 1, 1755 ZG Petten (Netherlands)

    2009-09-15

    The scope of this paper includes the development of a modelling approach to predict the ash release behaviour and chemical composition of inorganics during co-firing of coal and biomass. In the present work, an advanced analytical method was developed and introduced to determine the speciation of biomass using pH extraction analysis. Biomass samples considered for the study include wood chips, wood bark and straw. The speciation data was used as an input to the chemical speciation model to predict the behaviour and release of ash. It was found that the main gaseous species formed during the combustion of biomass are KCl, NaCl, K{sub 2}SO{sub 4} and Na{sub 2}SO{sub 4}. Calculations of gas-to-particle formation were also carried out to determine the chemical composition of coal and biomass during cooling which takes place in the boiler. It was found that the heterogeneous condensation occurring on heat exchange surfaces of boilers is much more than homogeneous condensation. Preliminary studies of interaction between coal and biomass during ash formation process showed that Al, Si and S elements in coal may have a 'buffering' effect on biomass alkali metals, thus reducing the release of alkali-gases which act as precursors to ash deposition and corrosion during co-firing. The results obtained in this work are considered to be valuable and form the basis for accurately determining the ash deposition during co-firing. (author)

  5. Difficulties of Pre-service Teachers in Developing and Implementing Teaching Activities Based on 5E Model in Constructivist Approach

    Directory of Open Access Journals (Sweden)

    Mustafa Metin

    2009-12-01

    Full Text Available This study aimed to determine difficulties of student teachers in developing and implementing teaching activities based on 5E model in constructivist approach. Thus, it was carried out in the context of Science Teaching II practices course in spring semester of 2007-2008 academic year. The sample group of the study consisted of 25 junior student-teachers at the Department of Classroom Teacher Education in Faculty of Education at Artvin Çoruh University. In the study, a qualitative research design was used, and it was implemented in three steps. In the first step, the pre-service teachers were given standards which were about fifth class Science and Technology course; then, they were asked to prepare an activity appropriate for 5E model. In the second step, they were asked to carry out those activities, and observations were carried out by one of the researchers. In the last step, semi-structured interviews were carried out with them. In the result of the study, the following problems were determined. The student-teachers were unable to use time effectively, to provide the classroom’s discipline, to apply the stage of the 5E model, to relate the concepts with daily life situation, to know how to evaluate appropriately and to attract attention of students.

  6. Hydraulic Modeling of Lock Approaches

    Science.gov (United States)

    2016-08-01

    cation was that the guidewall design changed from a solid wall to one on pilings in which water was allowed to flow through and/or under the wall ...develops innovative solutions in civil and military engineering, geospatial sciences, water resources, and environmental sciences for the Army, the...magnitudes and directions at lock approaches for open river conditions. The meshes were developed using the Surface- water Modeling System. The two

  7. Multiple Model Approaches to Modelling and Control,

    DEFF Research Database (Denmark)

    on the ease with which prior knowledge can be incorporated. It is interesting to note that researchers in Control Theory, Neural Networks,Statistics, Artificial Intelligence and Fuzzy Logic have more or less independently developed very similar modelling methods, calling them Local ModelNetworks, Operating...... of introduction of existing knowledge, as well as the ease of model interpretation. This book attempts to outlinemuch of the common ground between the various approaches, encouraging the transfer of ideas.Recent progress in algorithms and analysis is presented, with constructive algorithms for automated model...

  8. New Optimality Approach for Photosynthetic Parameterization in Terrestrial Biosphere Models: Development and Testing of VIC-VEO

    Science.gov (United States)

    Quebbeman, J.; Ramirez, J.

    2016-12-01

    Photosynthesis is intricately linked to the carbon, energy, and water cycles of our planet, and yet is commonly estimated in terrestrial biosphere models using grossly simplified descriptions and parameterizations. As our climate changes, vegetation both adapts and acclimates in ways not captured in these traditional modeling schemes. One of the most ubiquitous models of photosynthesis is the Farquhar, von Caemmerer, and Berry model, which considers at a minimum, two systems of so-called light and dark reactions. Critical parameters for each of these systems include the maximum rate of electron transport (Jmax), and the maximum rate of carboxylation (Vcmax), respectively. Although critical, these parameters are commonly either fixed at a reference temperature using estimates from literature, or follow simplified rules independent of climate. Here, we consider a new optimality approach allocating available nitrogen within the leaf such that the expectation of carbon assimilation is maximized. Further, the new approach responds dynamically to the environment, including non-stomatal down-regulation during water shortages. This new approach is discussed along with a case study replicating seasonal variability of photosynthetic capacity. Further, we introduce the VIC-VEO (VEgetal Optimality) model that implements the photosynthetic optimality approach, which is then applied across the Colorado River Basin in a water supply vulnerability case study. Results of this study show significant differences in both assimilation and transpiration between static and dynamic parameterizations of the photosynthetic system, emphasizing the need for more robust photosynthetic parameterization schemes in contemporary terrestrial biosphere models, such as utilizing optimality approaches.

  9. A sampling and analytical approach to develop spatial distribution models for sagebrush-associated species: Chapter 4

    Science.gov (United States)

    Leu, Matthias; Hanser, Steven E.; Aldridge, Cameron L.; Nielsen, Scott E.; Cade, Brian S.; Knick, Steven T.; Hanser, Steven E.; Leu, Matthias; Knick, Steven T.; Aldridge, Cameron L.

    2011-01-01

    Understanding multi-scale floral and faunal responses to human land use is crucial for informing natural resource management and conservation planning. However, our knowledge on how land use influences sagebrush (Artemisia spp.) ecosystems is limited primarily to site-specific studies. To fill this void, studies across large regions are needed that address how species are distributed relative to type, extent, and intensity of land use. We present a study design for the Wyoming Basin Ecoregional Assessment (WBEA) to sample sagebrush-associated flora and fauna along a land cover-human land use gradient. To minimize field costs, we sampled various taxonomic groups simultaneously on transects (ungulates and lagomorphs), point counts (song birds), and area-searches of 7.29-ha survey blocks (pellet counts, burrow counts, reptile surveys, medium-sized mammals, ant mounds, rodent trapping, and vegetation sampling of native and exotic plants). We then present an exploratory approach to develop species occurrence and abundance models when a priori model building is not an option. Our study design has broad applications for large-scale evaluations of arid ecosystems.

  10. Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition II: Computational Modeling

    Science.gov (United States)

    ABSTRACT Exposure to endocrine disrupting chemicals can affect reproduction and development in both humans and wildlife. We developed a mechanistic mathematical model of the hypothalamic­ pituitary-gonadal (HPG) axis in female fathead minnows to predic...

  11. Model Mapping Approach Based on Ontology Semantics

    Directory of Open Access Journals (Sweden)

    Jinkui Hou

    2013-09-01

    Full Text Available The mapping relations between different models are the foundation for model transformation in model-driven software development. On the basis of ontology semantics, model mappings between different levels are classified by using structural semantics of modeling languages. The general definition process for mapping relations is explored, and the principles of structure mapping are proposed subsequently. The approach is further illustrated by the mapping relations from class model of object oriented modeling language to the C programming codes. The application research shows that the approach provides a theoretical guidance for the realization of model mapping, and thus can make an effective support to model-driven software development

  12. A New Approach for Modeling Darrieus-Type Vertical Axis Wind Turbine Rotors Using Electrical Equivalent Circuit Analogy: Basis of Theoretical Formulations and Model Development

    National Research Council Canada - National Science Library

    Pierre Tchakoua; Rene Wamkeue; Mohand Ouhrouche; Tommy Andy Tameghe; Gabriel Ekemb

    2015-01-01

    .... Thus, models can significantly reduce design, development and optimization costs. This paper proposes a novel equivalent electrical model for Darrieus-type vertical axis wind turbines (DTVAWTs...

  13. Exploring interactions between music and language during the early development of music cognition. A computational modelling approach.

    OpenAIRE

    Salselas, Inês

    2013-01-01

    This dissertation concerns the computational modelling of early life development of music perception and cognition. Experimental psychology and neuroscience show results that suggest that the development of musical representations in infancy, whether concerning pitch or rhythm features, depend on exposure both to music and language. Early musical and linguistic skills seem to be, therefore, tangled in ways we are yet to characterize. In parallel, computational modelling has produced powerf...

  14. a Radical Collaborative Approach: Developing a Model for Learning Theory, Human-Based Computation and Participant Motivation in a Rock-Art Heritage Application

    Science.gov (United States)

    Haubt, R.

    2016-06-01

    This paper explores a Radical Collaborative Approach in the global and centralized Rock-Art Database project to find new ways to look at rock-art by making information more accessible and more visible through public contributions. It looks at rock-art through the Key Performance Indicator (KPI), identified with the latest Australian State of the Environment Reports to help develop a better understanding of rock-art within a broader Cultural and Indigenous Heritage context. Using a practice-led approach the project develops a conceptual collaborative model that is deployed within the RADB Management System. Exploring learning theory, human-based computation and participant motivation the paper develops a procedure for deploying collaborative functions within the interface design of the RADB Management System. The paper presents the results of the collaborative model implementation and discusses considerations for the next iteration of the RADB Universe within an Agile Development Approach.

  15. Modeling, Analysis and Simulation Approaches Used in Development of the National Aeronautics and Space Administration Max Launch Abort System

    Science.gov (United States)

    Yuchnovicz, Daniel E.; Dennehy, Cornelius J.; Schuster, David M.

    2011-01-01

    The National Aeronautics and Space Administration (NASA) Engineering and Safety Center was chartered to develop an alternate launch abort system (LAS) as risk mitigation for the Orion Project. Its successful flight test provided data for the design of future LAS vehicles. Design of the flight test vehicle (FTV) and pad abort trajectory relied heavily on modeling and simulation including computational fluid dynamics for vehicle aero modeling, 6-degree-of-freedom kinematics models for flight trajectory modeling, and 3-degree-of-freedom kinematics models for parachute force modeling. This paper highlights the simulation techniques and the interaction between the aerodynamics, flight mechanics, and aerodynamic decelerator disciplines during development of the Max Launch Abort System FTV.

  16. Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: Computational Modeling

    Science.gov (United States)

    Exposure to endocrine disrupting chemicals can affect reproduction and development in both humans and wildlife. We developed a mechanistic mathematical model of the hypothalamic-pituitary-gonadal (HPG) axis in female fathead minnows to predict dose-response and time-course (DRTC)...

  17. Developments in Plasticity Approach to Shear

    DEFF Research Database (Denmark)

    Hoang, Cao Linh; Nielsen, Mogens Peter

    1999-01-01

    The paper deals with plastic methods applied to shear design of reinforced concrete beams. Emphasis is put on the recently developed crack sliding model applicable to non-shear reinforced and lightly shear reinforced beams and slabs. The model, which is an upper bound plasticity approach, takes...

  18. Implementing an ally development model to promote safer schools for LGB youth: a trans-disciplinary approach.

    Science.gov (United States)

    Zammitt, Kimberly A; Pepperell, Jennifer; Coe, Megan

    2015-01-01

    Lesbian, gay, and bisexual (LGB) students experience ongoing bullying, harassment, and lack of safety in school. Specialized instructional support personnel (SISPs), such as school counselors, school social workers, and school psychologists, are in a unique position to advocate for LGB students and to implement an ally development model. The purpose of this article is to describe the current climate for LGB students, to discuss the current barriers facing SISPs in advocating for change, and to provide a model of ally development for use at each level of the K-12 system.

  19. A POMDP approach to Affective Dialogue Modeling

    NARCIS (Netherlands)

    Bui Huu Trung, B.H.T.; Poel, Mannes; Nijholt, Antinus; Zwiers, Jakob; Keller, E.; Marinaro, M.; Bratanic, M.

    2007-01-01

    We propose a novel approach to developing a dialogue model that is able to take into account some aspects of the user's affective state and to act appropriately. Our dialogue model uses a Partially Observable Markov Decision Process approach with observations composed of the observed user's

  20. A cognitive approach to game usability and design: mental model development in novice real-time strategy gamers.

    Science.gov (United States)

    Graham, John; Zheng, Liya; Gonzalez, Cleotilde

    2006-06-01

    We developed a technique to observe and characterize a novice real-time-strategy (RTS) player's mental model as it shifts with experience. We then tested this technique using an off-the-shelf RTS game, EA Games Generals. Norman defined mental models as, "an internal representation of a target system that provides predictive and explanatory power to the operator." In the case of RTS games, the operator is the player and the target system is expressed by the relationships within the game. We studied five novice participants in laboratory-controlled conditions playing a RTS game. They played Command and Conquer Generals for 2 h per day over the course of 5 days. A mental model analysis was generated using player dissimilarity-ratings of the game's artificial intelligence (AI) agents analyzed using multidimensional scaling (MDS) statistical methods. We hypothesized that novices would begin with an impoverished model based on the visible physical characteristics of the game system. As they gained experience and insight, their mental models would shift and accommodate the functional characteristics of the AI agents. We found that all five of the novice participants began with the predicted physical-based mental model. However, while their models did qualitatively shift with experience, they did not necessarily change to the predicted functional-based model. This research presents an opportunity for the design of games that are guided by shifts in a player's mental model as opposed to the typical progression through successive performance levels.

  1. A Systems Biology Approach to Understanding Alcoholic Liver Disease Molecular Mechanism: The Development of Static and Dynamic Models.

    Science.gov (United States)

    Shafaghati, Leila; Razaghi-Moghadam, Zahra; Mohammadnejad, Javad

    2017-08-28

    Alcoholic liver disease (ALD) is a complex disease characterized by damages to the liver and is the consequence of excessive alcohol consumption over years. Since this disease is associated with several pathway failures, pathway reconstruction and network analysis are likely to explicit the molecular basis of the disease. To this aim, in this paper, a network medicine approach was employed to integrate interactome (protein-protein interaction and signaling pathways) and transcriptome data to reconstruct both a static network of ALD and a dynamic model for it. Several data sources were exploited to assemble a set of ALD-associated genes which further was used for network reconstruction. Moreover, a comprehensive literature mining reveals that there are four signaling pathways with crosstalk (TLR4, NF- [Formula: see text]B, MAPK and Apoptosis) which play a major role in ALD. These four pathways were exploited to reconstruct a dynamic model of ALD. The results assure that these two models are consistent with a number of experimental observations. The static network of ALD and its dynamic model are the first models provided for ALD which offer potentially valuable information for researchers in this field.

  2. Development of lichen response indexes using a regional gradient modeling approach for large-scale monitoring of forests

    Science.gov (United States)

    Susan Will-Wolf; Peter Neitlich

    2010-01-01

    Development of a regional lichen gradient model from community data is a powerful tool to derive lichen indexes of response to environmental factors for large-scale and long-term monitoring of forest ecosystems. The Forest Inventory and Analysis (FIA) Program of the U.S. Department of Agriculture Forest Service includes lichens in its national inventory of forests of...

  3. Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: II. Computational modeling.

    Science.gov (United States)

    Breen, Miyuki; Villeneuve, Daniel L; Ankley, Gerald T; Bencic, David C; Breen, Michael S; Watanabe, Karen H; Lloyd, Alun L; Conolly, Rory B

    2013-06-01

    Endocrine-disrupting chemicals can affect reproduction and development in humans and wildlife. We developed a computational model of the hypothalamic-pituitary-gonadal (HPG) axis in female fathead minnows to predict dose-response and time-course (DRTC) behaviors for endocrine effects of the aromatase inhibitor, fadrozole (FAD). The model describes adaptive responses to endocrine stress involving regulated secretion of a generic gonadotropin (LH/FSH) from the hypothalamic-pituitary complex. For model development, we used plasma 17β-estradiol (E2) concentrations and ovarian cytochrome P450 (CYP) 19A aromatase mRNA data from two time-course experiments, each of which included both an exposure and a depuration phase, and plasma E2 data from a third 4-day study. Model parameters were estimated using E2 concentrations for 0, 0.5, and 3 µg/l FAD exposure concentrations, and good fits to these data were obtained. The model accurately predicted CYP19A mRNA fold changes for controls and three FAD doses (0, 0.5, and 3 µg/l) and plasma E2 dose response from the 4-day study. Comparing the model-predicted DRTC with experimental data provided insight into how the feedback control mechanisms in the HPG axis mediate these changes: specifically, adaptive changes in plasma E2 levels occurring during exposure and "overshoot" occurring postexposure. This study demonstrates the value of mechanistic modeling to examine and predict dynamic behaviors in perturbed systems. As this work progresses, we will obtain a refined understanding of how adaptive responses within the vertebrate HPG axis affect DRTC behaviors for aromatase inhibitors and other types of endocrine-active chemicals and apply that knowledge in support of risk assessments.

  4. Description and prediction of the development of metabolic syndrome: a longitudinal analysis using a markov model approach.

    Directory of Open Access Journals (Sweden)

    Lee-Ching Hwang

    Full Text Available BACKGROUND: Delineating the natural history of metabolic syndrome (MetS is prerequisite to prevention. This study aimed to build Markov models to simulate each component's progress and to test the effect of different initial states on the development of MetS. METHODS: MetS was defined with revised AHA/NHLBI criteria. Each reversible multistate Markov chain consisted of 8 states (no component, five isolated component states, 2-component state, and MetS state. Yearly transition probabilities were calculated from a five-year population-based follow up studywhich enrolled 2,247 individuals with mean aged 32.4 years at study entry. RESULTS: In men, high BP or a 2-component state was most likely to initiate the progress of MetS. In women, abdominal obesity or low HDL were the most likely initiators. Metabolic components were likely to occur together. The development of MetS was an increasing monotonic function of time. MetS was estimated to develop within 15 years in 12.7% of young men with no component, and 2 components developed in 16.3%. MetS was estimated to develop in 10.6% of women with at the age of 47, and 2 components developed in 14.3%. MetS was estimated to develop in 24.6% of men and 27.6% of women with abdominal obesity, a rate higher than in individuals initiating with no component. CONCLUSIONS: This modeling study allows estimation of the natural history of MetS. Men tended to develop this syndrome sooner than women did, i.e., before their fifth decade of life. Individuals with 1 or 2 components showed increased development of MetS.

  5. Arctic soil development on a series of marine terraces on central Spitsbergen, Svalbard: a combined geochronology, fieldwork and modelling approach

    Science.gov (United States)

    van der Meij, W. Marijn; Temme, Arnaud J. A. M.; de Kleijn, Christian M. F. J. J.; Reimann, Tony; Heuvelink, Gerard B. M.; Zwoliński, Zbigniew; Rachlewicz, Grzegorz; Rymer, Krzysztof; Sommer, Michael

    2016-06-01

    Soils in Arctic regions currently enjoy attention because of their sensitivity to climate change. It is therefore important to understand the natural processes and rates of development of these soils. Specifically, there is a need to quantify the rates and interactions between various landscape- and soil-forming processes. Soil chronosequences are ideal natural experiments for this purpose. In this contribution, we combine field observations, luminescence dating and soil-landscape modelling to improve and test our understanding of Arctic soil formation. The field site is a Holocene chronosequence of gravelly raised marine terraces in central Spitsbergen. Field observations show that soil-landscape development is mainly driven by weathering, silt translocation, aeolian deposition and rill erosion. Spatial soil variation is mainly caused by soil age, morphological position within a terrace and depth under the surface. Luminescence dating confirmed existing radiocarbon dating of the terraces, which are between ˜ 1.5 and ˜ 13.3 ka old. The soil-landscape evolution model LORICA was used to test our hypothesis that the field-observed processes indeed dominate soil-landscape development. Model results additionally indicated the importance of aeolian deposition as a source of fine material in the subsoil for both sheltered and vegetated trough positions and barren ridge positions. Simulated overland erosion was negligible. Consequently, an un-simulated process must be responsible for creating the observed erosion rills. Dissolution and physical weathering both play a major role. However, using present-day soil observations, the relative contribution of physical and chemical weathering could not be disentangled. Discrepancies between field and model results indicate that soil formation is non-linear and driven by spatially and temporally varying boundary conditions which were not included in the model. To conclude, Arctic soil and landscape development appears to be more

  6. THE ROLE OF ANDROGENS AND ESTROGENS IN THE DEVELOPMENT OF BRAIN AND PERIPHERAL NERVOUS SYSTEM: APPROACHES TO DEVELOPING ANIMAL MODELS FOR SEXUALLY DIMORPHIC BEHAVIORS

    Science.gov (United States)

    This presentation provides an overview of research on the effects of hormonally active chemicals on sexual differentiation of the brain including (a) research on the role of androgens and estrogens in the development of the brain and peripheral nervous system, (b) approaches to d...

  7. Distributed simulation a model driven engineering approach

    CERN Document Server

    Topçu, Okan; Oğuztüzün, Halit; Yilmaz, Levent

    2016-01-01

    Backed by substantive case studies, the novel approach to software engineering for distributed simulation outlined in this text demonstrates the potent synergies between model-driven techniques, simulation, intelligent agents, and computer systems development.

  8. Developing a systematic evaluation approach for training programs within a train-the-trainer model for youth cognitive behavior therapy.

    Science.gov (United States)

    Nakamura, Brad J; Selbo-Bruns, Alexandra; Okamura, Kelsie; Chang, Jaime; Slavin, Lesley; Shimabukuro, Scott

    2014-02-01

    The purpose of this small pilot study was three-fold: (a) to begin development of a coding scheme for supervisor and therapist skill acquisition, (b) to preliminarily investigate a pilot train-the-trainer paradigm for skill development, and (c) to evaluate self-reported versus observed indicators of skill mastery in that pilot program. Participants included four supervisor-therapist dyads (N = 8) working with public mental health sector youth. Master trainers taught cognitive-behavioral therapy techniques to supervisors, who in turn trained therapists on these techniques. Supervisor and therapist skill acquisition and supervisor use of teaching strategies were repeatedly assessed through coding of scripted role-plays with a multiple-baseline across participants and behaviors design. The coding system, the Practice Element Train the Trainer - Supervisor/Therapist Versions of the Therapy Process Observational Coding System for Child Psychotherapy, was developed and evaluated though the course of the investigation. The coding scheme demonstrated excellent reliability (ICCs [1,2] = 0.81-0.91) across 168 video recordings. As calculated through within-subject effect sizes, supervisor and therapist participants, respectively, evidenced skill improvements related to teaching and performing therapy techniques. Self-reported indicators of skill mastery were inflated in comparison to observed skill mastery. Findings lend initial support for further developing an evaluative approach for a train-the-trainer effort focused on disseminating evidence-based practices.

  9. A Comprehensive and Systematic Approach to Developing and Documenting Conceptual Models of Contaminant Release and Migration at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Last, George V.; Rohay, Virginia J.; Schelling, F J.; Bunn, Amoret L.; Delamare, Michael A.; Dirkes, Roger L.; Hildebrand, R D.; Morse, John G.; Napier, Bruce A.; Riley, Robert G.; Soler, Luis; Thorne, Paul D.

    2004-04-01

    The U. S. Department of Energy?s Richland Operations Office has initiated efforts to adapt and implement the Features, Events, and Processes (FEPs) methodology (used in scenario development for nuclear waste disposal programs) to the environmental management and remediation problems facing the Hanford Site. These efforts have shown that modification of the FEPs methodology to incorporate the use of Process Relationship Diagrams (PRD) is effective in facilitating the development of conceptual models and selection of potentially relevant factors to be incorporated into a specific performance assessment. In developing this methodology for Hanford, a master PRD was created to provide an organization structure for identifying the potentially relevant factors (i.e. FEPs) and for illustrating the relationships between these factors. This organizational framework was developed to match the organization of current Hanford site-wide performance assessment activities and to facilitate screening of the FEPs relevant to the problems (and conceptual models) that need to be addressed at the site. However, the link between Hanford specific FEPs and the international list of FEPs was maintained to demonstrate completeness and perhaps to expand the usefulness of the international list for other environmental programs.

  10. A New Approach for Modeling Darrieus-Type Vertical Axis Wind Turbine Rotors Using Electrical Equivalent Circuit Analogy: Basis of Theoretical Formulations and Model Development

    Directory of Open Access Journals (Sweden)

    Pierre Tchakoua

    2015-09-01

    Full Text Available Models are crucial in the engineering design process because they can be used for both the optimization of design parameters and the prediction of performance. Thus, models can significantly reduce design, development and optimization costs. This paper proposes a novel equivalent electrical model for Darrieus-type vertical axis wind turbines (DTVAWTs. The proposed model was built from the mechanical description given by the Paraschivoiu double-multiple streamtube model and is based on the analogy between mechanical and electrical circuits. This work addresses the physical concepts and theoretical formulations underpinning the development of the model. After highlighting the working principle of the DTVAWT, the step-by-step development of the model is presented. For assessment purposes, simulations of aerodynamic characteristics and those of corresponding electrical components are performed and compared.

  11. A Unified Approach to Modeling and Programming

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann; Møller-Pedersen, Birger

    2010-01-01

    of this paper is to go back to the future and get inspiration from SIMULA and propose a unied approach. In addition to reintroducing the contributions of SIMULA and the Scandinavian approach to object-oriented programming, we do this by discussing a number of issues in modeling and programming and argue3 why we......SIMULA was a language for modeling and programming and provided a unied approach to modeling and programming in contrast to methodologies based on structured analysis and design. The current development seems to be going in the direction of separation of modeling and programming. The goal...

  12. Development of a quantitative approach using surface-enhanced Raman chemical imaging: first step for the determination of an impurity in a pharmaceutical model.

    Science.gov (United States)

    De Bleye, C; Sacré, P-Y; Dumont, E; Netchacovitch, L; Chavez, P-F; Piel, G; Lebrun, P; Hubert, Ph; Ziemons, E

    2014-03-01

    This publication reports, for the first time, the development of a quantitative approach using surface-enhanced Raman chemical imaging (SER-CI). A pharmaceutical model presented as tablets based on paracetamol, which is the most sold drug around the world, was used to develop this approach. 4-Aminophenol is the main impurity of paracetamol and is actively researched in pharmaceutical formulations because of its toxicity. As its concentration is generally very low (<0.1%, w/w), conventional Raman chemical imaging cannot be used. In this context, a SER-CI method was developed to quantify 4-aminophenol assessing a limit of quantification below its limit of specification of 1000 ppm. Citrate-reduced silver nanoparticles were used as SERS substrate and these nanoparticles were functionalized using 1-butanethiol. Different ways to cover the tablets surface by butanethiol-functionalized silver nanoparticles were tested and a homogeneity study of the silver nanoparticles covering was realized. This homogeneity study was performed in order to choose the best way to cover the surface of tablets by silver colloid. Afterwards, the optimization of the SER-CI approach was necessary and different spectral intensity normalizations were tested. Finally, a quantitative approach using SER-CI was developed enabling to quantify 4-aminophenol from 0.025% to 0.2% in paracetamol tablets. This quantitative approach was tested on two different series of tablets using different batches of silver nanoparticles.

  13. DEVELOPMENT OF AN APPROACH TO MODELING LOADING AND ELUTION OF SPHERICAL RESORCINOL FORMALDEHYDE ION-EXCHANGE RESIN

    Energy Technology Data Exchange (ETDEWEB)

    Aleman, S.; Hamm, L.; Smith, F.

    2011-10-03

    The current strategy for removal of cesium from the Hanford waste stream is ion-exchange using spherical Resorcinol-Formaldehyde (sRF) resin. The original resin of choice was granular SuperLig 644 resin and during testing of this resin several operational issues were identified. For example, the granular material had a high angle of internal friction resulting in fragmentation of resin particles along its edges during cycling and adverse hydraulic performance. Efforts to replace SuperLig 644 were undertaken and one candidate was the granular Resorcinol-Formaldehyde (RF) resin where experience with this cation exchanger dates back to the late 1940's. To minimize hydraulic concerns a spherical version of RF was developed and several different chemically produced batches were created. The 5E-370/641 batch of sRF was selected and for the last decade numerous studies have been performed (e.g., batch contact tests, column loading and elution tests). The Waste Treatment Plant (WTP) flowsheet shows that the aqueous phase waste stream will have a wide range of ionic concentrations (e.g., during the loading step 0-3 M free OH, 5+ M Na, 0-1 M K, 0-3 M NO{sub 3}). Several steps are required in the ion-exchange process to achieve the required Cs separation factors: loading, displacement, washing, elution, and regeneration. The sRF resin will be operated over a wide range in pH (i.e., pH of 12-14 during the loading step and pH of 0.01-1 during the elution step). During some of these steps very high levels of counter-ions and co-ions will be present within the aqueous phase. Alternative process feeds are under consideration as well (e.g., sodium levels as high as 8 M and column operation up to 45 C during loading, reduced and recycled HNO{sub 3} during elution). In order to model the performance of sRF resin through an entire ion-exchange cycle, a more robust isotherm model is required. To achieve this more robust isotherm model requires knowledge of the numbers and kinds of

  14. Assessing the sensitivity of Melanoplus frigidus (Orthoptera:Acrididae) to different weather conditions: A modeling approach focussing on development times

    Institute of Scientific and Technical Information of China (English)

    Oliver-D. Finch; J(o)rg L(o)ffler; Roland Pape

    2008-01-01

    The temperature and soil moisture conditions as well as vegetation patterns were studied to describe the habitat and to model the life cycle of Melanoplusfrigidus, a true alpine grasshopper of the Scandes. In the low alpine belt of the Norwegian Scandes the species colonizes only the warmest microhabitats with maximum soil surface temperatures of 31℃. Vegetation of these habitats consists of shrub-rich heath dominated by Vaccinium myrtillus and Calluna vulgaris. Using continuously measured temperature data, the development times for four different seasons were modeled and related to field observations. The maximum delay of adult molt was estimated to amount to 3 weeks, the delay being determined by the variation in spring temperature conditions between different years. The possibilities of using M. frigidus as an indicator organism of climate change effects on alpine zoo-coenoses of the Scandes are discussed.

  15. Entrepreneurship and human development: A capability approach

    OpenAIRE

    Gries, Thomas; Naudé, Wim

    2010-01-01

    We provide a formal model of entrepreneurship in human development. The framework is provided by the capabilities approach (CA). Hence we extend not only the conceptualisation of entrepreneurship in development, but the reach of the CA into entrepreneurship. From a CA view, entrepreneurship is not only a production factor, or a means to an end, as is often taken to be the case by economists, but also an end in itself. Entrepreneurship can be a human functioning and can contribute towards expa...

  16. A mathematical approach to research problems of science and technology theoretical basis and developments in mathematical modeling

    CERN Document Server

    Ei, Shin-ichiro; Koiso, Miyuki; Ochiai, Hiroyuki; Okada, Kanzo; Saito, Shingo; Shirai, Tomoyuki

    2014-01-01

    This book deals with one of the most novel advances in mathematical modeling for applied scientific technology, including computer graphics, public-key encryption, data visualization, statistical data analysis, symbolic calculation, encryption, error correcting codes, and risk management. It also shows that mathematics can be used to solve problems from nature, e.g., slime mold algorithms. One of the unique features of this book is that it shows readers how to use pure and applied mathematics, especially those mathematical theory/techniques developed in the twentieth century, and developing now, to solve applied problems in several fields of industry. Each chapter includes clues on how to use "mathematics" to solve concrete problems faced in industry as well as practical applications. The target audience is not limited to researchers working in applied mathematics and includes those in engineering, material sciences, economics, and life sciences.

  17. A rapid and cost-effective approach for the development of polymorphic microsatellites in non-model species using paired-end RAD sequencing.

    Science.gov (United States)

    Xue, Dong-Xiu; Li, Yu-Long; Liu, Jin-Xian

    2017-06-20

    As one of the most informative and versatile DNA-based markers, microsatellites have been widely used in population and conservation genetic studies. However, the development of microsatellites has traditionally been laborious, time-consuming, and expensive. In the present study, a rapid and cost-effective "RAD-seq-Assembly-Microsatellite" approach was developed to identify abundant microsatellite markers in non-model species using the roughskin sculpin Trachidermus fasciatus as a representative. Overlapping paired-end Illumina reads generated by restriction-site-associated DNA sequencing (RAD-seq) were clustered based on the similarity of reads containing the restriction enzyme recognition site and then assembled into contigs, which were used for microsatellite discovery and primer design. A total of 121,750 RAD contigs were generated with a mean length of 522 bp, and 19,782 contigs contained microsatellite motifs. A total of 156,150 primer pairs were successfully designed based on 16,497 contigs containing priming sites. Experimental validation of 52 randomly selected microsatellite loci demonstrated that 45 (86.54%) loci were successfully amplified and polymorphic in two geographically isolated populations of T. fasciatus. Compared with traditional approaches based on DNA cloning and other approaches based on next-generation sequencing, our newly developed approach could yield thousands of microsatellite loci with much higher successful amplification rate and lower costs, especially for non-model species with shallow background of genomic information. The "RAD-seq-Assembly-Microsatellite" approach holds great promise for microsatellite development in future ecological and evolutionary studies of non-model species.

  18. The role of sediment-transport evaluations for development of modeled instream flows: policy and approach in Texas.

    Science.gov (United States)

    Heitmuller, Franklin T; Raphelt, Nolan

    2012-07-15

    Instream-flow scientists embrace streamflow as the master variable driving aquatic and riparian ecosystems, and that natural flow variability is imperative for river conservation and restoration efforts. Sediment transport, which is critical for maintenance of physical habitats in rivers and floodplains, has received less direct attention from instream-flow practitioners. This article serves to highlight the roles of sediment-transport evaluations in modifying or verifying instream-flow prescriptions based on hydrology alone. Two examples of sediment-transport evaluations are discussed in relation to the Texas Senate Bill 3 Environmental Flows allocation process, a mandate to "develop environmental flow analyses and a recommended flow regime" that "maintain(s) the viability of the state's streams, rivers, and bay and estuary systems" using "reasonably available science". The first example provides an evaluation of effective discharge of suspended-sediment load of the lower Brazos River. The magnitude and frequency of effective discharge occurs between typical high-flow pulses and overbank flows, indicating that hydrologic and physical processes are not optimally coupled in some flow-regime models. The second example utilizes the Hydrology-Based Environmental Flow Regime (HEFR) model to prescribe instream flows for the lower Sabine River, and compares modeled bed-material loads for observed and HEFR-prescribed flow regimes. Results indicate that annual water and sediment yields are greatly reduced for the modeled flow regime. It should be noted, however, that different input variables to the HEFR model would have resulted in different computations of water and sediment yields, reinforcing that instream-flow practitioners should exercise great caution when applying rule-of-thumb procedures to generate flow prescriptions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Econometric models for biohydrogen development.

    Science.gov (United States)

    Lee, Duu-Hwa; Lee, Duu-Jong; Veziroglu, Ayfer

    2011-09-01

    Biohydrogen is considered as an attractive clean energy source due to its high energy content and environmental-friendly conversion. Analyzing various economic scenarios can help decision makers to optimize development strategies for the biohydrogen sector. This study surveys econometric models of biohydrogen development, including input-out models, life-cycle assessment approach, computable general equilibrium models, linear programming models and impact pathway approach. Fundamentals of each model were briefly reviewed to highlight their advantages and disadvantages. The input-output model and the simplified economic input-output life-cycle assessment model proved most suitable for economic analysis of biohydrogen energy development. A sample analysis using input-output model for forecasting biohydrogen development in the United States is given.

  20. Meta-hierarchical-heuristic-mathematical- model of loading problems in flexible manufacturing system for development of an intelligent approach

    Directory of Open Access Journals (Sweden)

    Ranbir Singh

    2016-04-01

    Full Text Available Flexible manufacturing system (FMS promises a wide range of manufacturing benefits in terms of flexibility and productivity. These benefits are targeted by efficient production planning. Part type selection, machine grouping, deciding production ratio, resource allocation and machine loading are five identified production planning problems. Machine loading is the most identified complex problem solved with aid of computers. System up gradation and newer technology adoption are the primary needs of efficient FMS generating new scopes of research in the field. The literature review is carried and the critical analysis is being executed in the present work. This paper presents the outcomes of the mathematical modelling techniques for loading of machines in FMS’s. It was also analysed that the mathematical modelling is necessary for accurate and reliable analysis for practical applications. However, excessive computations need to be avoided and heuristics have to be used for real-world problems. This paper presents the heuristics-mathematical modelling of loading problem with machine processing time as primary input. The aim of the present work is to solve a real-world machine loading problem with an objective of balancing the workload of the FMS with decreased computational time. A Matlab code is developed for the solution and the results are found most accurate and reliable as presented in the paper.

  1. From basic physics to mechanisms of toxicity: the "liquid drop" approach applied to develop predictive classification models for toxicity of metal oxide nanoparticles.

    Science.gov (United States)

    Sizochenko, Natalia; Rasulev, Bakhtiyor; Gajewicz, Agnieszka; Kuz'min, Victor; Puzyn, Tomasz; Leszczynski, Jerzy

    2014-11-21

    Many metal oxide nanoparticles are able to cause persistent stress to live organisms, including humans, when discharged to the environment. To understand the mechanism of metal oxide nanoparticles' toxicity and reduce the number of experiments, the development of predictive toxicity models is important. In this study, performed on a series of nanoparticles, the comparative quantitative-structure activity relationship (nano-QSAR) analyses of their toxicity towards E. coli and HaCaT cells were established. A new approach for representation of nanoparticles' structure is presented. For description of the supramolecular structure of nanoparticles the "liquid drop" model was applied. It is expected that a novel, proposed approach could be of general use for predictions related to nanomaterials. In addition, in our study fragmental simplex descriptors and several ligand-metal binding characteristics were calculated. The developed nano-QSAR models were validated and reliably predict the toxicity of all studied metal oxide nanoparticles. Based on the comparative analysis of contributed properties in both models the LDM-based descriptors were revealed to have an almost similar level of contribution to toxicity in both cases, while other parameters (van der Waals interactions, electronegativity and metal-ligand binding characteristics) have unequal contribution levels. In addition, the models developed here suggest different mechanisms of nanotoxicity for these two types of cells.

  2. Blue and green infrastructures implementation to solve stormwater management issues in a new urban development project - a modelling approach

    Science.gov (United States)

    Versini, Pierre-Antoine; Tchiguirinskaia, Ioulia; Schertzer, Daniel

    2016-04-01

    Concentrating buildings and socio-economic activities, urban areas are particularly vulnerable to hydrological risks. Modification in climate may intensify already existing issues concerning stormwater management (due to impervious area) and water supply (due to the increase of the population). In this context, water use efficiency and best water management practices are key-issues in the urban environment already stressed. Blue and green infrastructures are nature-based solutions that provide synergy of the blue and green systems to provide multifunctional solutions and multiple benefits: increased amenity, urban heat island improvement, biodiversity, reduced energy requirements... They are particularly efficient to reduce the potential impact of new and existing developments with respect to stormwater and/or water supply issues. The Multi-Hydro distributed rainfall-runoff model represents an adapted tool to manage the impacts of such infrastructures at the urban basin scale. It is a numerical platform that makes several models interact, each of them representing a specific portion of the water cycle in an urban environment: surface runoff and infiltration depending on a land use classification, sub-surface processes and sewer network drainage. Multi-Hydro is still being developed at the Ecole des Ponts (open access from https://hmco.enpc.fr/Tools-Training/Tools/Multi-Hydro.php) to take into account the wide complexity of urban environments. The latest advancements have made possible the representation of several blue and green infrastructures (green roof, basin, swale). Applied in a new urban development project located in the Paris region, Multi-Hydro has been used to simulate the impact of blue and green infrastructures implementation. It was particularly focused on their ability to fulfil regulation rules established by local stormwater managers in order to connect the parcel to the sewer network. The results show that a combination of several blue and green

  3. Climatic and physiographic controls on catchment-scale nitrate loss at different spatial scales: insights from a top-down model development approach

    Science.gov (United States)

    Shafii, Mahyar; Basu, Nandita; Schiff, Sherry; Van Cappellen, Philippe

    2017-04-01

    Dramatic increase in nitrogen circulating in the biosphere due to anthropogenic activities has resulted in impairment of water quality in groundwater and surface water causing eutrophication in coastal regions. Understanding the fate and transport of nitrogen from landscape to coastal areas requires exploring the drivers of nitrogen processes in both time and space, as well as the identification of appropriate flow pathways. Conceptual models can be used as diagnostic tools to provide insights into such controls. However, diagnostic evaluation of coupled hydrological-biogeochemical models is challenging. This research proposes a top-down methodology utilizing hydrochemical signatures to develop conceptual models for simulating the integrated streamflow and nitrate responses while taking into account dominant controls on nitrate variability (e.g., climate, soil water content, etc.). Our main objective is to seek appropriate model complexity that sufficiently reproduces multiple hydrological and nitrate signatures. Having developed a suitable conceptual model for a given watershed, we employ it in sensitivity studies to demonstrate the dominant process controls that contribute to the nitrate response at scales of interest. We apply the proposed approach to nitrate simulation in a range of small to large sub-watersheds in the Grand River Watershed (GRW) located in Ontario. Such multi-basin modeling experiment will enable us to address process scaling and investigate the consequences of lumping processes in terms of models' predictive capability. The proposed methodology can be applied to the development of large-scale models that can help decision-making associated with nutrients management at regional scale.

  4. Modeling the structure of the attitudes and belief scale 2 using CFA and bifactor approaches: Toward the development of an abbreviated version.

    Science.gov (United States)

    Hyland, Philip; Shevlin, Mark; Adamson, Gary; Boduszek, Daniel

    2014-01-01

    The Attitudes and Belief Scale-2 (ABS-2: DiGiuseppe, Leaf, Exner, & Robin, 1988. The development of a measure of rational/irrational thinking. Paper presented at the World Congress of Behavior Therapy, Edinburg, Scotland.) is a 72-item self-report measure of evaluative rational and irrational beliefs widely used in Rational Emotive Behavior Therapy research contexts. However, little psychometric evidence exists regarding the measure's underlying factor structure. Furthermore, given the length of the ABS-2 there is a need for an abbreviated version that can be administered when there are time demands on the researcher, such as in clinical settings. This study sought to examine a series of theoretical models hypothesized to represent the latent structure of the ABS-2 within an alternative models framework using traditional confirmatory factor analysis as well as utilizing a bifactor modeling approach. Furthermore, this study also sought to develop a psychometrically sound abbreviated version of the ABS-2. Three hundred and thirteen (N = 313) active emergency service personnel completed the ABS-2. Results indicated that for each model, the application of bifactor modeling procedures improved model fit statistics, and a novel eight-factor intercorrelated solution was identified as the best fitting model of the ABS-2. However, the observed fit indices failed to satisfy commonly accepted standards. A 24-item abbreviated version was thus constructed and an intercorrelated eight-factor solution yielded satisfactory model fit statistics. Current results support the use of a bifactor modeling approach to determining the factor structure of the ABS-2. Furthermore, results provide empirical support for the psychometric properties of the newly developed abbreviated version.

  5. What do lay people want to know about the disposal of nuclear waste? A mental model approach to the design and development of an online risk communication.

    Science.gov (United States)

    Skarlatidou, A; Cheng, T; Haklay, M

    2012-09-01

    Public participation requires the involvement of lay people in the decision-making processes of issues that concern them. It is currently practiced in a variety of domains, such as transport and environmental planning. Communicating risks can be a complex task, as there may be significant differences between the risk perceptions of experts and those of lay people. Among the plethora of problems that require public involvement is the site selection of a nuclear waste disposal site in the United Kingdom, which is discussed in this article. Previous ineffective attempts to locate a site provide evidence that the problem has a strong social dimension, and studies ascribe public opposition to a loss of public trust in governmental agencies and decisionmakers, and to a lack of public understanding of nuclear waste issues. Although the mental models approach has been successfully used in the effective communication of such risks as climate change, no attempt has been made to follow a prescriptive mental model approach to develop risk communication messages that inform lay people about nuclear waste disposal. After interviewing 20 lay people and 5 experts, we construct and compare their corresponding mental models to reveal any gaps and misconceptions. The mental models approach is further applied here to identify lay people's requirements regarding what they want to know about nuclear waste, and how this information should be presented so that it is easily understood. This article further describes how the mental models approach was used in the subsequent development of an online information system for the site selection of a nuclear waste repository in the United Kingdom, which is considered essential for the improvement of public understanding and the reestablishment of trust. © 2012 Society for Risk Analysis.

  6. Integrated approach for hybrid rocket technology development

    Science.gov (United States)

    Barato, Francesco; Bellomo, Nicolas; Pavarin, Daniele

    2016-11-01

    Hybrid rocket motors tend generally to be simple from a mechanical point of view but difficult to optimize because of their complex and still not well understood cross-coupled physics. This paper addresses the previous issue presenting the integrated approach established at University of Padua to develop hybrid rocket based systems. The methodology tightly combines together system analysis and design, numerical modeling from elementary to sophisticated CFD, and experimental testing done with incremental philosophy. As an example of the approach, the paper presents the experience done in the successful development of a hybrid rocket booster designed for rocket assisted take off operations. It is thought that following the proposed approach and selecting carefully the most promising applications it is possible to finally exploit the major advantages of hybrid rocket motors as safety, simplicity, low cost and reliability.

  7. Multiple Model Approaches to Modelling and Control,

    DEFF Research Database (Denmark)

    Why Multiple Models?This book presents a variety of approaches which produce complex models or controllers by piecing together a number of simpler subsystems. Thisdivide-and-conquer strategy is a long-standing and general way of copingwith complexity in engineering systems, nature and human probl...

  8. Current approaches to gene regulatory network modelling

    Directory of Open Access Journals (Sweden)

    Brazma Alvis

    2007-09-01

    Full Text Available Abstract Many different approaches have been developed to model and simulate gene regulatory networks. We proposed the following categories for gene regulatory network models: network parts lists, network topology models, network control logic models, and dynamic models. Here we will describe some examples for each of these categories. We will study the topology of gene regulatory networks in yeast in more detail, comparing a direct network derived from transcription factor binding data and an indirect network derived from genome-wide expression data in mutants. Regarding the network dynamics we briefly describe discrete and continuous approaches to network modelling, then describe a hybrid model called Finite State Linear Model and demonstrate that some simple network dynamics can be simulated in this model.

  9. A structural equation modelling approach to predicting adoption of a patient-handling intervention developed for EMS providers.

    Science.gov (United States)

    Weiler, Monica R; Lavender, Steven A; Crawford, J Mac; Reichelt, Paul A; Conrad, Karen M; Browne, Michael W

    2013-01-01

    Patient-handling tasks are integral to Emergency Medical Service (EMS) work as are the musculoskeletal injuries associated with these tasks. The aim of this study was to develop and test a structural equation model that describes the interactions between previously identified factors that contribute to the adoption of a specific ergonomics intervention designed for EMS work. EMS responders (n = 187), from six different organisations, participated in a 2-month longitudinal study following the introduction of a foldable patient transfer-board (slide-board) designed to assist with lateral patient transfers. Surveys administered at baseline, after 1 month and after 2 months sampled factors potentially influencing EMS responders' adoption decisions. Perceived ergonomics advantage, which was influenced by access and storage concerns and prior tool experience, contributed most strongly to intention to use at the end of the first month and to the emergence of champions, which contributed to the intention to use at the end of the second month.

  10. Analyzing Information Systems Development: A Comparison and Analysis of Eight IS Development Approaches.

    Science.gov (United States)

    Iivari, Juhani; Hirschheim, Rudy

    1996-01-01

    Analyzes and compares eight information systems (IS) development approaches: Information Modelling, Decision Support Systems, the Socio-Technical approach, the Infological approach, the Interactionist approach, the Speech Act-based approach, Soft Systems Methodology, and the Scandinavian Trade Unionist approach. Discusses the organizational roles…

  11. The Ecological Approach to Development: An Alternative to Cognitivism.

    Science.gov (United States)

    Wilcox, Stephen; Katz, Stuart

    1981-01-01

    Two approaches to development are identified--ecological and cognitive. A comparison of the two approaches is made, and decisions are made favoring the ecological approach. A detailed description of the advantages of the ecological approach is provided by means of a systems theory model. (Author/DB)

  12. From basic physics to mechanisms of toxicity: the ``liquid drop'' approach applied to develop predictive classification models for toxicity of metal oxide nanoparticles

    Science.gov (United States)

    Sizochenko, Natalia; Rasulev, Bakhtiyor; Gajewicz, Agnieszka; Kuz'min, Victor; Puzyn, Tomasz; Leszczynski, Jerzy

    2014-10-01

    Many metal oxide nanoparticles are able to cause persistent stress to live organisms, including humans, when discharged to the environment. To understand the mechanism of metal oxide nanoparticles' toxicity and reduce the number of experiments, the development of predictive toxicity models is important. In this study, performed on a series of nanoparticles, the comparative quantitative-structure activity relationship (nano-QSAR) analyses of their toxicity towards E. coli and HaCaT cells were established. A new approach for representation of nanoparticles' structure is presented. For description of the supramolecular structure of nanoparticles the ``liquid drop'' model was applied. It is expected that a novel, proposed approach could be of general use for predictions related to nanomaterials. In addition, in our study fragmental simplex descriptors and several ligand-metal binding characteristics were calculated. The developed nano-QSAR models were validated and reliably predict the toxicity of all studied metal oxide nanoparticles. Based on the comparative analysis of contributed properties in both models the LDM-based descriptors were revealed to have an almost similar level of contribution to toxicity in both cases, while other parameters (van der Waals interactions, electronegativity and metal-ligand binding characteristics) have unequal contribution levels. In addition, the models developed here suggest different mechanisms of nanotoxicity for these two types of cells.Many metal oxide nanoparticles are able to cause persistent stress to live organisms, including humans, when discharged to the environment. To understand the mechanism of metal oxide nanoparticles' toxicity and reduce the number of experiments, the development of predictive toxicity models is important. In this study, performed on a series of nanoparticles, the comparative quantitative-structure activity relationship (nano-QSAR) analyses of their toxicity towards E. coli and HaCaT cells were

  13. BUSINESS MODEL IN ELECTRICITY INDUSTRY USING BUSINESS MODEL CANVAS APPROACH; THE CASE OF PT. XYZ

    National Research Council Canada - National Science Library

    Wicaksono, Achmad Arief; Syarief, Rizal; Suparno, Ono

    2017-01-01

    .... This study aims to identify company's business model using Business Model Canvas approach, formulate business development strategy alternatives, and determine the prioritized business development...

  14. Development of a Working Model of the Comparative Advantages Approach to Affirmative Debate Case Construction. Final Report.

    Science.gov (United States)

    Matheny, David L.

    This study attempted to determine if the "comparative advantages" debate case is a legitimate and logical approach to affirmative case construction in college and high school debate. The study population totaled 25 high school debate directors and 40 college and university debate directors. Four tape-recorded debates, in which an affirmative team…

  15. Development of a Combined In Vitro Physiologically Based Kinetic (PBK) and Monte Carlo Modelling Approach to Predict Interindividual Human Variation in Phenol-Induced Developmental Toxicity.

    Science.gov (United States)

    Strikwold, Marije; Spenkelink, Bert; Woutersen, Ruud A; Rietjens, Ivonne M C M; Punt, Ans

    2017-06-01

    With our recently developed in vitro physiologically based kinetic (PBK) modelling approach, we could extrapolate in vitro toxicity data to human toxicity values applying PBK-based reverse dosimetry. Ideally information on kinetic differences among human individuals within a population should be considered. In the present study, we demonstrated a modelling approach that integrated in vitro toxicity data, PBK modelling and Monte Carlo simulations to obtain insight in interindividual human kinetic variation and derive chemical specific adjustment factors (CSAFs) for phenol-induced developmental toxicity. The present study revealed that UGT1A6 is the primary enzyme responsible for the glucuronidation of phenol in humans followed by UGT1A9. Monte Carlo simulations were performed taking into account interindividual variation in glucuronidation by these specific UGTs and in the oral absorption coefficient. Linking Monte Carlo simulations with PBK modelling, population variability in the maximum plasma concentration of phenol for the human population could be predicted. This approach provided a CSAF for interindividual variation of 2.0 which covers the 99th percentile of the population, which is lower than the default safety factor of 3.16 for interindividual human kinetic differences. Dividing the dose-response curve data obtained with in vitro PBK-based reverse dosimetry, with the CSAF provided a dose-response curve that reflects the consequences of the interindividual variability in phenol kinetics for the developmental toxicity of phenol. The strength of the presented approach is that it provides insight in the effect of interindividual variation in kinetics for phenol-induced developmental toxicity, based on only in vitro and in silico testing. © The Author 2017. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  16. Examining the Relationship between Teachers' Attitudes and Motivation toward Web-Based Professional Development: A Structural Equation Modeling Approach

    Science.gov (United States)

    Chien, Hui-Min; Kao, Chia-Pin; Yeh, I-Jan; Lin, Kuen-Yi

    2012-01-01

    This study was conducted to investigate elementary school teachers' attitudes and motivation toward web-based professional development. The relationship between teachers' attitudes and motivation was explored using the AWPD (Attitudes toward Web-based Professional Development) and MWPD (Motivation toward Web-based Professional Development)…

  17. Model Construct Based Enterprise Model Architecture and Its Modeling Approach

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In order to support enterprise integration, a kind of model construct based enterprise model architecture and its modeling approach are studied in this paper. First, the structural makeup and internal relationships of enterprise model architecture are discussed. Then, the concept of reusable model construct (MC) which belongs to the control view and can help to derive other views is proposed. The modeling approach based on model construct consists of three steps, reference model architecture synthesis, enterprise model customization, system design and implementation. According to MC based modeling approach a case study with the background of one-kind-product machinery manufacturing enterprises is illustrated. It is shown that proposal model construct based enterprise model architecture and modeling approach are practical and efficient.

  18. A Systematic Approach for Soft Sensor Development

    DEFF Research Database (Denmark)

    Lin, Bao; Recke, Bodil; Renaudat, Philippe

    2007-01-01

    This paper presents a systematic approach based on robust statistical techniques for development of a data-driven soft sensor, which is an important component of the process analytical technology (PAT) and is essential for effective quality control. The data quality is obviously of essential...... significance for a data-driven soft sensor. Therefore, preprocessing procedures for process measurements are described in detail. First, a template is defined based on one or more key process variables to handle missing data related to severe operation interruptions. Second, a univariate, followed...... by a multivariate principal component analysis (PCA) approach, is used to detect outlying observations. Then, robust regression techniques are employed to derive an inferential model. A dynamic partial least squares (DPLS) model is implemented to address the issue of auto-correlation in process data and thus...

  19. Development and Evaluation of a Questionnaire Measuring Pre-Service Teachers' Teaching Behaviour: A Rasch Modelling Approach

    Science.gov (United States)

    Maulana, Ridwan; Helms-Lorenz, Michelle; van de Grift, Wim

    2015-01-01

    The present study examines the development of a measure tapping students' perceptions of (pre-service) teachers' teaching behaviour to explore the practical value of such a measure in teacher education and teacher professional development programs. From a sample of 1,635 students of 91 pre-service teachers teaching in secondary education in The…

  20. A Multi-Expert Approach for Developing Testing and Diagnostic Systems Based on the Concept-Effect Model

    Science.gov (United States)

    Panjaburee, Patcharin; Hwang, Gwo-Jen; Triampo, Wannapong; Shih, Bo-Ying

    2010-01-01

    With the popularization of computer and communication technologies, researchers have attempted to develop computer-assisted testing and diagnostic systems to help students improve their learning performance on the Internet. In developing a diagnostic system for detecting students' learning problems, it is difficult for individual teachers to…

  1. [Ecologo-economical model of the region development based on the expert approach (example of Bieszczad montain region, Poland)].

    Science.gov (United States)

    Menshutkin, V V; Klekovski, R Z

    2001-01-01

    A computer simulation has been developed for the dynamics of forest communities and abundance of wild animals in the Bieszczad mountain region (Carpathians, Southern Poland) at the background of changing quality of water resulting from the development of tourism and agriculture. The simulation operates on scaled variables in the 0-1 range. The functional relationships in the simulation were determined by the Delphi evaluation. The simulation was used to consider scenarios of various environmental influences of the region-climatic factors (warming and changed rainfall) as well as anthropogenic disturbances (development of tourism, agriculture, and commercial hunting). The simulation can be adapted for other regions.

  2. Developing a long-term global tourism transport model using a behavioural approach: implications for sustainable tourism policy making.

    NARCIS (Netherlands)

    Peeters, P.M.

    2013-01-01

    This paper explores the creation and use of a long-term global tourism transport model for private and public sector tourism policy makers. Given that technology is unlikely to reduce tourism transport's impact on climate change sufficiently to avoid serious dangers, behavioural change is necessary.

  3. Developing a long-term global tourism transport model using a behavioural approach: implications for sustainable tourism policy making.

    NARCIS (Netherlands)

    Peeters, P.M.

    2013-01-01

    This paper explores the creation and use of a long-term global tourism transport model for private and public sector tourism policy makers. Given that technology is unlikely to reduce tourism transport's impact on climate change sufficiently to avoid serious dangers, behavioural change is necessary.

  4. Radioimmunotherapy: Development of an effective approach

    Energy Technology Data Exchange (ETDEWEB)

    1987-01-01

    Goals of this program are to answer the fundamental scientific questions for the development of an effective approach for delivering radiation therapy to cancer on antibody-based radiopharmaceuticals. The following list consists of highlights of developments from our program: documented therapeutic response of lymphoma in patients receiving radioimmunotherapy; development and application of quantitative radionuclide imaging techniques for therapy planning and dosimetry calculations; multicompartmental modeling and analysis of the in vivo MoAb kinetics in patients; a MoAb macrocycle chelate for Cu-67: development, production, in vitro and in vivo testing; NMR analysis of immunoradiotherapeutic effects on the metabolism of lymphoma; analysis of the variable molecular characteristics of the MoAb radiopharmaceutical, and their significance; in vivo studies in mice and patients of the metabolism of radioiodinated MoAb as well as In-111 CITC MoAb; and biodistribution of Cu-67 TETA MoAb in nude mice with human lymphoma.

  5. IMPACT fragmentation model developments

    Science.gov (United States)

    Sorge, Marlon E.; Mains, Deanna L.

    2016-09-01

    The IMPACT fragmentation model has been used by The Aerospace Corporation for more than 25 years to analyze orbital altitude explosions and hypervelocity collisions. The model is semi-empirical, combining mass, energy and momentum conservation laws with empirically derived relationships for fragment characteristics such as number, mass, area-to-mass ratio, and spreading velocity as well as event energy distribution. Model results are used for several types of analysis including assessment of short-term risks to satellites from orbital altitude fragmentations, prediction of the long-term evolution of the orbital debris environment and forensic assessments of breakup events. A new version of IMPACT, version 6, has been completed and incorporates a number of advancements enabled by a multi-year long effort to characterize more than 11,000 debris fragments from more than three dozen historical on-orbit breakup events. These events involved a wide range of causes, energies, and fragmenting objects. Special focus was placed on the explosion model, as the majority of events examined were explosions. Revisions were made to the mass distribution used for explosion events, increasing the number of smaller fragments generated. The algorithm for modeling upper stage large fragment generation was updated. A momentum conserving asymmetric spreading velocity distribution algorithm was implemented to better represent sub-catastrophic events. An approach was developed for modeling sub-catastrophic explosions, those where the majority of the parent object remains intact, based on estimated event energy. Finally, significant modifications were made to the area-to-mass ratio distribution to incorporate the tendencies of different materials to fragment into different shapes. This ability enabled better matches between the observed area-to-mass ratios and those generated by the model. It also opened up additional possibilities for post-event analysis of breakups. The paper will discuss

  6. The Sustainable Development Model

    OpenAIRE

    2012-01-01

    Sustainable development concept approaches quality of life in complexity, as economic, social and environmental issues, promoting the idea of balance between economic development, social equity, efficient utilization and environment conservation.     An essential condition for achieving sustainable development is the right mix of macroeconomic policies coherent, consistent with resources to ensure sustainability of materials and energy used for growth.

  7. Arctic soil development on a series of marine terraces on central Spitsbergen, Svalbard: a combined geochronology, fieldwork and modelling approach

    NARCIS (Netherlands)

    Meij, van der W.M.; Temme, A.J.A.M.; Kleijn, de Christian; Reimann, T.; Heuvelink, G.B.M.; Zwoliński, Zbigniew; Rachlewicz, Grzegorz; Rymer, Krzysztof; Sommer, Michael

    2016-01-01

    Soils in Arctic regions currently enjoy attention because of their sensitivity to climate change. It is therefore important to understand the natural processes and rates of development of these soils. Specifically, there is a need to quantify the rates and interactions between various landscape- and

  8. A Hybrid Approach to Develop an Analytical Model for Enhancing the Service Quality of E-Learning

    Science.gov (United States)

    Wu, Hung-Yi; Lin, Hsin-Yu

    2012-01-01

    The digital content industry is flourishing as a result of the rapid development of technology and the widespread use of computer networks. As has been reported, the market size of the global e-learning (i.e., distance education and telelearning) will reach USD 49.6 billion in 2014. However, to retain and/or increase the market share associated…

  9. A Hybrid Approach to Develop an Analytical Model for Enhancing the Service Quality of E-Learning

    Science.gov (United States)

    Wu, Hung-Yi; Lin, Hsin-Yu

    2012-01-01

    The digital content industry is flourishing as a result of the rapid development of technology and the widespread use of computer networks. As has been reported, the market size of the global e-learning (i.e., distance education and telelearning) will reach USD 49.6 billion in 2014. However, to retain and/or increase the market share associated…

  10. Career Development: A Systems Approach.

    Science.gov (United States)

    Slavenski, Lynn

    1987-01-01

    The author describes a comprehensive career development system implemented by Coca-Cola USA. The system's objectives are (1) to promote from within, (2) to develop talent for the future, (3) to make managers responsible for development efforts, and (4) to make individuals ultimately responsible for their development. (CH)

  11. A Multiple Model Approach to Modeling Based on LPF Algorithm

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Input-output data fitting methods are often used for unknown-structure nonlinear system modeling. Based on model-on-demand tactics, a multiple model approach to modeling for nonlinear systems is presented. The basic idea is to find out, from vast historical system input-output data sets, some data sets matching with the current working point, then to develop a local model using Local Polynomial Fitting (LPF) algorithm. With the change of working points, multiple local models are built, which realize the exact modeling for the global system. By comparing to other methods, the simulation results show good performance for its simple, effective and reliable estimation.``

  12. HEADROOM APPROACH TO DEVICE DEVELOPMENT: CURRENT AND FUTURE DIRECTIONS

    OpenAIRE

    Girling, A; Lilford, R; Cole, A; Young, T

    2015-01-01

    OBJECTIVES: The headroom approach to medical device development relies on the estimation of a value-based price ceiling at different stages of the development cycle. Such price-ceilings delineate the commercial opportunities for new products in many healthcare systems. We apply a simple model to obtain critical business information as the product proceeds along a development pathway, and indicate some future directions for the development of the approach. METHODS: Health economic modelling in...

  13. Developing Novel Therapeutic Approaches in Small Cell Lung Carcinoma Using Genetically Engineered Mouse Models and Human Circulating Tumor Cells

    Science.gov (United States)

    2014-10-01

    Massachusetts General Hospital Boston, MA 02114-2621 REPORT DATE: October 2014 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel...Massachusetts General Hospital Boston MA 02114 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical...during the first year of funding. We developed a dual- color immunofluorescence stain to identify nucleated (DAPI-positive) SCLC cells that express

  14. Developing a model: an illustration.

    Science.gov (United States)

    Havenga, Yolanda; Poggenpoel, Marie; Myburgh, Chris

    2014-04-01

    Model development may seem a daunting task for the novice. The purpose of this article is to illustrate the steps of model development applied to a real-life phenomenon using an inductive theory-generating research approach. The value of the illustration is that nurse researchers can follow the application of the process as a point of departure for their own work. A logical stepwise discussion is followed for empirical theory development. The logical thought process from identifying the phenomenon to describing the model as a visual metaphor of the phenomenon is illustrated.

  15. LP Approach to Statistical Modeling

    OpenAIRE

    Mukhopadhyay, Subhadeep; Parzen, Emanuel

    2014-01-01

    We present an approach to statistical data modeling and exploratory data analysis called `LP Statistical Data Science.' It aims to generalize and unify traditional and novel statistical measures, methods, and exploratory tools. This article outlines fundamental concepts along with real-data examples to illustrate how the `LP Statistical Algorithm' can systematically tackle different varieties of data types, data patterns, and data structures under a coherent theoretical framework. A fundament...

  16. Heat transfer modeling an inductive approach

    CERN Document Server

    Sidebotham, George

    2015-01-01

    This innovative text emphasizes a "less-is-more" approach to modeling complicated systems such as heat transfer by treating them first as "1-node lumped models" that yield simple closed-form solutions. The author develops numerical techniques for students to obtain more detail, but also trains them to use the techniques only when simpler approaches fail. Covering all essential methods offered in traditional texts, but with a different order, Professor Sidebotham stresses inductive thinking and problem solving as well as a constructive understanding of modern, computer-based practice. Readers learn to develop their own code in the context of the material, rather than just how to use packaged software, offering a deeper, intrinsic grasp behind models of heat transfer. Developed from over twenty-five years of lecture notes to teach students of mechanical and chemical engineering at The Cooper Union for the Advancement of Science and Art, the book is ideal for students and practitioners across engineering discipl...

  17. Stormwater infiltration trenches: a conceptual modelling approach.

    Science.gov (United States)

    Freni, Gabriele; Mannina, Giorgio; Viviani, Gaspare

    2009-01-01

    In recent years, limitations linked to traditional urban drainage schemes have been pointed out and new approaches are developing introducing more natural methods for retaining and/or disposing of stormwater. These mitigation measures are generally called Best Management Practices or Sustainable Urban Drainage System and they include practices such as infiltration and storage tanks in order to reduce the peak flow and retain part of the polluting components. The introduction of such practices in urban drainage systems entails an upgrade of existing modelling frameworks in order to evaluate their efficiency in mitigating the impact of urban drainage systems on receiving water bodies. While storage tank modelling approaches are quite well documented in literature, some gaps are still present about infiltration facilities mainly dependent on the complexity of the involved physical processes. In this study, a simplified conceptual modelling approach for the simulation of the infiltration trenches is presented. The model enables to assess the performance of infiltration trenches. The main goal is to develop a model that can be employed for the assessment of the mitigation efficiency of infiltration trenches in an integrated urban drainage context. Particular care was given to the simulation of infiltration structures considering the performance reduction due to clogging phenomena. The proposed model has been compared with other simplified modelling approaches and with a physically based model adopted as benchmark. The model performed better compared to other approaches considering both unclogged facilities and the effect of clogging. On the basis of a long-term simulation of six years of rain data, the performance and the effectiveness of an infiltration trench measure are assessed. The study confirmed the important role played by the clogging phenomenon on such infiltration structures.

  18. Modeling diffuse pollution with a distributed approach.

    Science.gov (United States)

    León, L F; Soulis, E D; Kouwen, N; Farquhar, G J

    2002-01-01

    The transferability of parameters for non-point source pollution models to other watersheds, especially those in remote areas without enough data for calibration, is a major problem in diffuse pollution modeling. A water quality component was developed for WATFLOOD (a flood forecast hydrological model) to deal with sediment and nutrient transport. The model uses a distributed group response unit approach for water quantity and quality modeling. Runoff, sediment yield and soluble nutrient concentrations are calculated separately for each land cover class, weighted by area and then routed downstream. The distributed approach for the water quality model for diffuse pollution in agricultural watersheds is described in this paper. Integrating the model with data extracted using GIS technology (Geographical Information Systems) for a local watershed, the model is calibrated for the hydrologic response and validated for the water quality component. With the connection to GIS and the group response unit approach used in this paper, model portability increases substantially, which will improve non-point source modeling at the watershed scale level.

  19. Modelling Coagulation Systems: A Stochastic Approach

    CERN Document Server

    Ryazanov, V V

    2011-01-01

    A general stochastic approach to the description of coagulating aerosol system is developed. As the object of description one can consider arbitrary mesoscopic values (number of aerosol clusters, their size etc). The birth-and-death formalism for a number of clusters can be regarded as a partial case of the generalized storage model. An application of the storage model to the number of monomers in a cluster is discussed.

  20. Challenges in structural approaches to cell modeling.

    Science.gov (United States)

    Im, Wonpil; Liang, Jie; Olson, Arthur; Zhou, Huan-Xiang; Vajda, Sandor; Vakser, Ilya A

    2016-07-31

    Computational modeling is essential for structural characterization of biomolecular mechanisms across the broad spectrum of scales. Adequate understanding of biomolecular mechanisms inherently involves our ability to model them. Structural modeling of individual biomolecules and their interactions has been rapidly progressing. However, in terms of the broader picture, the focus is shifting toward larger systems, up to the level of a cell. Such modeling involves a more dynamic and realistic representation of the interactomes in vivo, in a crowded cellular environment, as well as membranes and membrane proteins, and other cellular components. Structural modeling of a cell complements computational approaches to cellular mechanisms based on differential equations, graph models, and other techniques to model biological networks, imaging data, etc. Structural modeling along with other computational and experimental approaches will provide a fundamental understanding of life at the molecular level and lead to important applications to biology and medicine. A cross section of diverse approaches presented in this review illustrates the developing shift from the structural modeling of individual molecules to that of cell biology. Studies in several related areas are covered: biological networks; automated construction of three-dimensional cell models using experimental data; modeling of protein complexes; prediction of non-specific and transient protein interactions; thermodynamic and kinetic effects of crowding; cellular membrane modeling; and modeling of chromosomes. The review presents an expert opinion on the current state-of-the-art in these various aspects of structural modeling in cellular biology, and the prospects of future developments in this emerging field. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Approach for estimating microbial growth and the biodegradation of hydrocarbon contaminants in subsoil based on field measurements: 1. Model development and verification.

    Science.gov (United States)

    Song, Dejun; Katayama, Arata

    2010-01-15

    An approach was developed to represent the microbial growth and corresponding biodegradation of hydrocarbons (HCs) during the natural attenuation process based on field measurements of in situ microbial biomass and residual HC concentrations in unsaturated subsurface soil. A kinetic model combining Monod and logistic kinetics represents microbial growth under the limitation of HCs as substrates and environmental factors at actual contaminated sites by the introduction of two new kinetic parameters, the effective rate and the self-limiting coefficient of microbial growth. The correspondence between microbial growth and the biodegradation of HCs in the soil is obtained by dividing the amount of HC and the corresponding degrading microbial groups into two classes: saturated HCs as inert components and aromatic HCs that form a contamination plume as dissolved components. The respiratory quinones were used as indicators of microbial biomass. The biodegradation capacity of contaminated sites was evaluated by the maximum microbial biomass obtained by field measurements, which is considered as the integrated results from measurements of HCs, degrading kinetics, and environmental factors at the site. The feasibility of the proposed approach was verified at two hypothetical contaminated sites. The results suggested that the proposed approach is feasible for application at actual HC-contaminated sites.

  2. A multiscale approach to blast neurotrauma modeling: Part I - Development of novel test devices for in vivo and in vitro blast injury models

    Directory of Open Access Journals (Sweden)

    Matthew B Panzer

    2012-03-01

    Full Text Available The loading conditions used in some current in vivo and in vitro blast-induced neurotrauma models may not be representative of real-world blast conditions. To address these limitations, we developed a compressed-gas driven shock tube with different driven lengths that can generate Friedlander-type blasts. The shock tube can generate overpressures up to 650 kPa with durations between 0.3 and 1.1 ms using compressed helium driver gas, and peak overpressures up to 450 kPa with durations between 0.6 and 3 ms using compressed nitrogen. This device is used for short duration blast overpressure loading for small animal in vivo injury models, and contrasts the more frequently used long duration/high impulse blast overpressures in the literature. We also developed a new apparatus that is used with the shock tube to recreate the in vivo intracranial overpressure response for loading in vitro culture preparations. The receiver device surrounds the culture with materials of similar impedance to facilitate the propagation of a single overpressure pulse through the tissue. This method prevents pressure waves reflecting off the tissue that can cause unrealistic deformation and injury. The receiver performance was characterized using the longest helium-driven shock tube, and produced in-fluid overpressures up to 1500 kPa at the location where a culture would be placed. This response was well correlated with the overpressure conditions from the shock tube (R2 = 0.97. Finite element models of the shock tube and receiver were developed and validated to better elucidate the mechanics of this methodology. A demonstration exposing a culture to the loading conditions created by this system suggest tissue strains less than 5% for all pressure levels simulated, which was well below functional deficit thresholds for strain rates less than 50 s-1. This novel system is not limited to a specific type of culture model and can be modified to reproduce more complex pressure

  3. Development of an Antarctic digital elevation model by integrating cartographic and remotely sensed data: A geographic information system based approach

    Science.gov (United States)

    Liu, Hongxing; Jezek, Kenneth C.; Li, Biyan

    1999-10-01

    We present a high-resolution digital elevation model (DEM) of the Antarctic. It was created in a geographic information system (GIS) environment by integrating the best available topographic data from a variety of sources. Extensive GIS-based error detection and correction operations ensured that our DEM is free of gross errors. The carefully designed interpolation algorithms for different types of source data and incorporation of surface morphologic information preserved and enhanced the fine surface structures present in the source data. The effective control of adverse edge effects and the use of the Hermite blending weight function in data merging minimized the discontinuities between different types of data, leading to a seamless and topographically consistent DEM throughout the Antarctic. This new DEM provides exceptional topographical details and represents a substantial improvement in horizontal resolution and vertical accuracy over the earlier, continental-scale renditions, particularly in mountainous and coastal regions. It has a horizontal resolution of 200 m over the rugged mountains, 400 m in the coastal regions, and approximately 5 km in the interior. The vertical accuracy of the DEM is estimated at about 100-130 m over the rugged mountainous area, better than 2 m for the ice shelves, better than 15 m for the interior ice sheet, and about 35 m for the steeper ice sheet perimeter. The Antarctic DEM can be obtained from the authors.

  4. Develop a Model Component

    Science.gov (United States)

    Ensey, Tyler S.

    2013-01-01

    During my internship at NASA, I was a model developer for Ground Support Equipment (GSE). The purpose of a model developer is to develop and unit test model component libraries (fluid, electrical, gas, etc.). The models are designed to simulate software for GSE (Ground Special Power, Crew Access Arm, Cryo, Fire and Leak Detection System, Environmental Control System (ECS), etc. .) before they are implemented into hardware. These models support verifying local control and remote software for End-Item Software Under Test (SUT). The model simulates the physical behavior (function, state, limits and 110) of each end-item and it's dependencies as defined in the Subsystem Interface Table, Software Requirements & Design Specification (SRDS), Ground Integrated Schematic (GIS), and System Mechanical Schematic.(SMS). The software of each specific model component is simulated through MATLAB's Simulink program. The intensiv model development life cycle is a.s follows: Identify source documents; identify model scope; update schedule; preliminary design review; develop model requirements; update model.. scope; update schedule; detailed design review; create/modify library component; implement library components reference; implement subsystem components; develop a test script; run the test script; develop users guide; send model out for peer review; the model is sent out for verifictionlvalidation; if there is empirical data, a validation data package is generated; if there is not empirical data, a verification package is generated; the test results are then reviewed; and finally, the user. requests accreditation, and a statement of accreditation is prepared. Once each component model is reviewed and approved, they are intertwined together into one integrated model. This integrated model is then tested itself, through a test script and autotest, so that it can be concluded that all models work conjointly, for a single purpose. The component I was assigned, specifically, was a

  5. An Approach to Developing a Prediction Model of Fertility Intent Among HIV-Positive Women and Men in Cape Town, South Africa: A Case Study.

    Science.gov (United States)

    Bai, Dan; Leu, Cheng-Shiun; Mantell, Joanne E; Exner, Theresa M; Cooper, Diane; Hoffman, Susie; Kelvin, Elizabeth A; Myer, Landon; Constant, Debbie; Moodley, Jennifer

    2017-02-01

    As a 'case-study' to demonstrate an approach to establishing a fertility-intent prediction model, we used data collected from recently diagnosed HIV-positive women (N = 69) and men (N = 55) who reported inconsistent condom use and were enrolled in a sexual and reproductive health intervention in public sector HIV care clinics in Cape Town, South Africa. Three theoretically-driven prediction models showed reasonable sensitivity (0.70-1.00), specificity (0.66-0.94), and area under the receiver operating characteristic curve (0.79-0.89) for predicting fertility intent at the 6-month visit. A k-fold cross-validation approach was employed to reduce bias due to over-fitting of data in estimating sensitivity, specificity, and area under the curve. We discuss how the methods presented might be used in future studies to develop a clinical screening tool to identify HIV-positive individuals likely to have future fertility intent and who could therefore benefit from sexual and reproductive health counseling around fertility options.

  6. Towards new approaches in phenological modelling

    Science.gov (United States)

    Chmielewski, Frank-M.; Götz, Klaus-P.; Rawel, Harshard M.; Homann, Thomas

    2014-05-01

    Modelling of phenological stages is based on temperature sums for many decades, describing both the chilling and the forcing requirement of woody plants until the beginning of leafing or flowering. Parts of this approach go back to Reaumur (1735), who originally proposed the concept of growing degree-days. Now, there is a growing body of opinion that asks for new methods in phenological modelling and more in-depth studies on dormancy release of woody plants. This requirement is easily understandable if we consider the wide application of phenological models, which can even affect the results of climate models. To this day, in phenological models still a number of parameters need to be optimised on observations, although some basic physiological knowledge of the chilling and forcing requirement of plants is already considered in these approaches (semi-mechanistic models). Limiting, for a fundamental improvement of these models, is the lack of knowledge about the course of dormancy in woody plants, which cannot be directly observed and which is also insufficiently described in the literature. Modern metabolomic methods provide a solution for this problem and allow both, the validation of currently used phenological models as well as the development of mechanistic approaches. In order to develop this kind of models, changes of metabolites (concentration, temporal course) must be set in relation to the variability of environmental (steering) parameters (weather, day length, etc.). This necessarily requires multi-year (3-5 yr.) and high-resolution (weekly probes between autumn and spring) data. The feasibility of this approach has already been tested in a 3-year pilot-study on sweet cherries. Our suggested methodology is not only limited to the flowering of fruit trees, it can be also applied to tree species of the natural vegetation, where even greater deficits in phenological modelling exist.

  7. Fractional magnetization plateaus of the spin-1/2 Heisenberg orthogonal-dimer chain: Strong-coupling approach developed from the exactly solved Ising-Heisenberg model

    Science.gov (United States)

    Verkholyak, Taras; Strečka, Jozef

    2016-10-01

    The spin-1/2 Heisenberg orthogonal-dimer chain is considered within the perturbative strong-coupling approach, which is developed from the exactly solved spin-1/2 Ising-Heisenberg orthogonal-dimer chain with the Heisenberg intradimer and the Ising interdimer couplings. Although the spin-1/2 Ising-Heisenberg orthogonal-dimer chain exhibits just intermediate plateaus at zero, one-quarter, and one-half of the saturation magnetization, the perturbative treatment up to second order stemming from this exactly solvable model additionally corroborates the fractional one-third plateau as well as the gapless Luttinger spin-liquid phase. It is evidenced that the approximate results obtained from the strong-coupling approach are in an excellent agreement with the state-of-the-art numerical data obtained for the spin-1/2 Heisenberg orthogonal-dimer chain within the exact diagonalization and density-matrix renormalization group method. The nature of individual quantum ground states is comprehensively studied within the developed perturbation theory.

  8. Decomposition approach to model smart suspension struts

    Science.gov (United States)

    Song, Xubin

    2008-10-01

    Model and simulation study is the starting point for engineering design and development, especially for developing vehicle control systems. This paper presents a methodology to build models for application of smart struts for vehicle suspension control development. The modeling approach is based on decomposition of the testing data. Per the strut functions, the data is dissected according to both control and physical variables. Then the data sets are characterized to represent different aspects of the strut working behaviors. Next different mathematical equations can be built and optimized to best fit the corresponding data sets, respectively. In this way, the model optimization can be facilitated in comparison to a traditional approach to find out a global optimum set of model parameters for a complicated nonlinear model from a series of testing data. Finally, two struts are introduced as examples for this modeling study: magneto-rheological (MR) dampers and compressible fluid (CF) based struts. The model validation shows that this methodology can truly capture macro-behaviors of these struts.

  9. Information Processing Approaches to Cognitive Development

    Science.gov (United States)

    1989-08-04

    This chapter reviews the history and current status of information- processing approaches to cognitive development . Because the approach is so...a detailed analysis of self-modifying production systems and their potential for formulating theories of cognitive development . Keywords: Information processing; Cognitive development ; Self modification; Production system.

  10. Approaches to Modeling of Recrystallization

    Directory of Open Access Journals (Sweden)

    Håkan Hallberg

    2011-10-01

    Full Text Available Control of the material microstructure in terms of the grain size is a key component in tailoring material properties of metals and alloys and in creating functionally graded materials. To exert this control, reliable and efficient modeling and simulation of the recrystallization process whereby the grain size evolves is vital. The present contribution is a review paper, summarizing the current status of various approaches to modeling grain refinement due to recrystallization. The underlying mechanisms of recrystallization are briefly recollected and different simulation methods are discussed. Analytical and empirical models, continuum mechanical models and discrete methods as well as phase field, vertex and level set models of recrystallization will be considered. Such numerical methods have been reviewed previously, but with the present focus on recrystallization modeling and with a rapidly increasing amount of related publications, an updated review is called for. Advantages and disadvantages of the different methods are discussed in terms of applicability, underlying assumptions, physical relevance, implementation issues and computational efficiency.

  11. Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus

    Directory of Open Access Journals (Sweden)

    Martin Čulen

    2015-01-01

    Full Text Available Different batches of atorvastatin, represented by two immediate release formulation designs, were studied using a novel dynamic dissolution apparatus, simulating stomach and small intestine. A universal dissolution method was employed which simulated the physiology of human gastrointestinal tract, including the precise chyme transit behavior and biorelevant conditions. The multicompartmental dissolution data allowed direct observation and qualitative discrimination of the differences resulting from highly pH dependent dissolution behavior of the tested batches. Further evaluation of results was performed using IVIVC/IVIVR development. While satisfactory correlation could not be achieved using a conventional deconvolution based-model, promising results were obtained through the use of a nonconventional approach exploiting the complex compartmental dissolution data.

  12. Developing mathematical modelling competence

    DEFF Research Database (Denmark)

    Blomhøj, Morten; Jensen, Tomas Højgaard

    2003-01-01

    In this paper we introduce the concept of mathematical modelling competence, by which we mean being able to carry through a whole mathematical modelling process in a certain context. Analysing the structure of this process, six sub-competences are identified. Mathematical modelling competence...... cannot be reduced to these six sub-competences, but they are necessary elements in the development of mathematical modelling competence. Experience from the development of a modelling course is used to illustrate how the different nature of the sub-competences can be used as a tool for finding...... the balance between different kinds of activities in a particular educational setting. Obstacles of social, cognitive and affective nature for the students' development of mathematical modelling competence are reported and discussed in relation to the sub-competences....

  13. Development of a dynamic energy budget modeling approach to investigate the effects of temperature and resource limitation on mercury bioaccumulation in Fundulus heteroclitus.

    Science.gov (United States)

    Dynamic energy budget (DEB) theory provides a generalizable and broadly applicable framework to connect sublethal toxic effects on individuals to changes in population survival and growth. To explore this approach, we are developing growth and bioaccumulation studies that contrib...

  14. Molecular approaches to contraceptive development

    Indian Academy of Sciences (India)

    Usha Natraj

    2001-11-01

    The next generation of contraceptives will be based on the identification of novel molecules essential for reproductive processes and will rely on the refinement of older as well as newer technologies. Functional analysis of naturally occurring reproductive genetic disorders and creation of mice null for specific genes would greatly assist in the choice of genetic targets for contraceptive development. Structure-based design of drugs as exemplified by the preparation of an orally active non-peptide gonadotropin releasing hormone (GnRH) would revolutionize drug formulation and delivery for a peptide analogue. This review examines some of the molecular targets that may change contraceptive choices in the future.

  15. RISK ANALYSIS DEVELOPED MODEL

    Directory of Open Access Journals (Sweden)

    Georgiana Cristina NUKINA

    2012-07-01

    Full Text Available Through Risk analysis developed model deciding whether control measures suitable for implementation. However, the analysis determines whether the benefits of a data control options cost more than the implementation.

  16. Towards a Multiscale Approach to Cybersecurity Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Hogan, Emilie A.; Hui, Peter SY; Choudhury, Sutanay; Halappanavar, Mahantesh; Oler, Kiri J.; Joslyn, Cliff A.

    2013-11-12

    We propose a multiscale approach to modeling cyber networks, with the goal of capturing a view of the network and overall situational awareness with respect to a few key properties--- connectivity, distance, and centrality--- for a system under an active attack. We focus on theoretical and algorithmic foundations of multiscale graphs, coming from an algorithmic perspective, with the goal of modeling cyber system defense as a specific use case scenario. We first define a notion of \\emph{multiscale} graphs, in contrast with their well-studied single-scale counterparts. We develop multiscale analogs of paths and distance metrics. As a simple, motivating example of a common metric, we present a multiscale analog of the all-pairs shortest-path problem, along with a multiscale analog of a well-known algorithm which solves it. From a cyber defense perspective, this metric might be used to model the distance from an attacker's position in the network to a sensitive machine. In addition, we investigate probabilistic models of connectivity. These models exploit the hierarchy to quantify the likelihood that sensitive targets might be reachable from compromised nodes. We believe that our novel multiscale approach to modeling cyber-physical systems will advance several aspects of cyber defense, specifically allowing for a more efficient and agile approach to defending these systems.

  17. Modelling hormonal response and development.

    Science.gov (United States)

    Voß, Ute; Bishopp, Anthony; Farcot, Etienne; Bennett, Malcolm J

    2014-05-01

    As our knowledge of the complexity of hormone homeostasis, transport, perception, and response increases, and their outputs become less intuitive, modelling is set to become more important. Initial modelling efforts have focused on hormone transport and response pathways. However, we now need to move beyond the network scales and use multicellular and multiscale modelling approaches to predict emergent properties at different scales. Here we review some examples where such approaches have been successful, for example, auxin-cytokinin crosstalk regulating root vascular development or a study of lateral root emergence where an iterative cycle of modelling and experiments lead to the identification of an overlooked role for PIN3. Finally, we discuss some of the remaining biological and technical challenges. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. Simulation-based model checking approach to cell fate specification during Caenorhabditis elegans vulval development by hybrid functional Petri net with extension

    Directory of Open Access Journals (Sweden)

    Ueno Kazuko

    2009-04-01

    Full Text Available Abstract Background Model checking approaches were applied to biological pathway validations around 2003. Recently, Fisher et al. have proved the importance of model checking approach by inferring new regulation of signaling crosstalk in C. elegans and confirming the regulation with biological experiments. They took a discrete and state-based approach to explore all possible states of the system underlying vulval precursor cell (VPC fate specification for desired properties. However, since both discrete and continuous features appear to be an indispensable part of biological processes, it is more appropriate to use quantitative models to capture the dynamics of biological systems. Our key motivation of this paper is to establish a quantitative methodology to model and analyze in silico models incorporating the use of model checking approach. Results A novel method of modeling and simulating biological systems with the use of model checking approach is proposed based on hybrid functional Petri net with extension (HFPNe as the framework dealing with both discrete and continuous events. Firstly, we construct a quantitative VPC fate model with 1761 components by using HFPNe. Secondly, we employ two major biological fate determination rules – Rule I and Rule II – to VPC fate model. We then conduct 10,000 simulations for each of 48 sets of different genotypes, investigate variations of cell fate patterns under each genotype, and validate the two rules by comparing three simulation targets consisting of fate patterns obtained from in silico and in vivo experiments. In particular, an evaluation was successfully done by using our VPC fate model to investigate one target derived from biological experiments involving hybrid lineage observations. However, the understandings of hybrid lineages are hard to make on a discrete model because the hybrid lineage occurs when the system comes close to certain thresholds as discussed by Sternberg and Horvitz in

  19. The concept of runoff elements as a basis of scale-free approach to runoff formation modelling - the experience of the model "Hydrograph" development and implementation

    Science.gov (United States)

    Vinogradov, Yu. B.; Semenova, O.

    2009-04-01

    The concept of runoff elements used in proposed model as a base for calculating routine describing slope runoff transformation gives the opportunity to avoid the scale problem in hydrological modelling which, to our opinion, mainly refers to mathematical approaches (the framework of Navier-Stokes equations) widely used for description of water movement within the basin. River basin is a system of elementary watersheds of surface and underground ones of various layers. The topography of river basin surface conditionally can be presented by a system of the inclined surfaces each of them being an elementary slope. Within a surface elementary slope water flowing down is realized over non-channel rill system and within the underground elementary slope - over the underground drainage system. The elementary slopes and watersheds in their turn consist of a system of runoff elements - limited by micro-divides areas of the surface and underground elementary slopes and watersheds exposed with their open part to the slope non-channel or underground drainage system. Runoff elements are not the kind of idealization but they can be easily identified with the natural formations. Surface runoff elements depending on natural conditions but mainly on inclination can be measured from shares and ones up to tens of thousand square meters. Underground runoff elements can be much greater. For each runoff element there is a balance ratio (1) There is the unique nonlinear relation between W and outflow dischargeR: (2) Then, the corresponding equation of the outflow hydrograph from runoff elements of a given layer is the following: (3) Here R0 is the initial value of runoff R and S is the runoff rate (m3s-1); Δt is the computational time interval (sec) during which S is constant; a,b - hydraulic coefficients (which determine the conditions of outflow) with dimension m-3 and m3 s-1. In the general case, we assume that the number of runoff elements is proportional to the basin area F (m2

  20. Pedagogic process modeling: Humanistic-integrative approach

    Directory of Open Access Journals (Sweden)

    Boritko Nikolaj M.

    2007-01-01

    Full Text Available The paper deals with some current problems of modeling the dynamics of the subject-features development of the individual. The term "process" is considered in the context of the humanistic-integrative approach, in which the principles of self education are regarded as criteria for efficient pedagogic activity. Four basic characteristics of the pedagogic process are pointed out: intentionality reflects logicality and regularity of the development of the process; discreteness (stageability in dicates qualitative stages through which the pedagogic phenomenon passes; nonlinearity explains the crisis character of pedagogic processes and reveals inner factors of self-development; situationality requires a selection of pedagogic conditions in accordance with the inner factors, which would enable steering the pedagogic process. Offered are two steps for singling out a particular stage and the algorithm for developing an integrative model for it. The suggested conclusions might be of use for further theoretic research, analyses of educational practices and for realistic predicting of pedagogical phenomena. .

  1. Cost estimation of feature oriented software development: Statistical approach

    Directory of Open Access Journals (Sweden)

    Jawad Khan

    2016-12-01

    Full Text Available Software cost estimation is the important part of software development and used to predict the effort which is mandatory part for development of software system. Feature Model is a set of products that represents set of feature in feature model. Software cost estimation is about predicting amount of cost in software development cycle. SCE give analysis both to user as well customer regarding to budging planning. In this paper we have represent a statistical approach for finding cost estimation of feature oriented software development. We have used CPM approach from which we will find commonality as well cost of each feature which will be deploy in feature oriented software development.

  2. Continuum modeling an approach through practical examples

    CERN Document Server

    Muntean, Adrian

    2015-01-01

    This book develops continuum modeling skills and approaches the topic from three sides: (1) derivation of global integral laws together with the associated local differential equations, (2) design of constitutive laws and (3) modeling boundary processes. The focus of this presentation lies on many practical examples covering aspects such as coupled flow, diffusion and reaction in porous media or microwave heating of a pizza, as well as traffic issues in bacterial colonies and energy harvesting from geothermal wells. The target audience comprises primarily graduate students in pure and applied mathematics as well as working practitioners in engineering who are faced by nonstandard rheological topics like those typically arising in the food industry.

  3. Lightweight approach to model traceability in a CASE tool

    Science.gov (United States)

    Vileiniskis, Tomas; Skersys, Tomas; Pavalkis, Saulius; Butleris, Rimantas; Butkiene, Rita

    2017-07-01

    A term "model-driven" is not at all a new buzzword within the ranks of system development community. Nevertheless, the ever increasing complexity of model-driven approaches keeps fueling all kinds of discussions around this paradigm and pushes researchers forward to research and develop new and more effective ways to system development. With the increasing complexity, model traceability, and model management as a whole, becomes indispensable activities of model-driven system development process. The main goal of this paper is to present a conceptual design and implementation of a practical lightweight approach to model traceability in a CASE tool.

  4. Developing Phenomena Models from Experimental Data

    DEFF Research Database (Denmark)

    A systematic approach for developing phenomena models from experimental data is presented. The approach is based on integrated application of stochastic differential equation (SDE) modelling and multivariate nonparametric regression, and it is shown how these techniques can be used to uncover...... unknown functionality behind various phenomena in first engineering principles models using experimental data. The proposed modelling approach has significant application potential, e.g. for determining unknown reaction kinetics in both chemical and biological processes. To illustrate the performance...... of the approach, a case study is presented, which shows how an appropriate phenomena model for the growth rate of biomass in a fed-batch bioreactor can be inferred from data....

  5. Developing Phenomena Models from Experimental Data

    DEFF Research Database (Denmark)

    Kristensen, Niels Rode; Madsen, Henrik; Jørgensen, Sten Bay

    2003-01-01

    A systematic approach for developing phenomena models from experimental data is presented. The approach is based on integrated application of stochastic differential equation (SDE) modelling and multivariate nonparametric regression, and it is shown how these techniques can be used to uncover...... unknown functionality behind various phenomena in first engineering principles models using experimental data. The proposed modelling approach has significant application potential, e.g. for determining unknown reaction kinetics in both chemical and biological processes. To illustrate the performance...... of the approach, a case study is presented, which shows how an appropriate phenomena model for the growth rate of biomass in a fed-batch bioreactor can be inferred from data....

  6. APPROACHING DEVELOPMENT IN LOGISTIC INFORMATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    Louis F Buys

    2012-01-01

    Full Text Available The introduction of technology into modern defence necessitates integrated computerized information systems to render effective and efficient logistic support. Traditional information system development does not ensure attainment of use and time scale requirements in the continuously developing environment of logistics. This paper describes current approaches to the development of logistic information systems.

  7. A Complemental Approach to Instructional Development.

    Science.gov (United States)

    Hassan, M. H.

    In its relatively short history, instructional development has been greatly influenced by operant conditioning theory and methodology. This approach has been described by some as simplistic, inhuman, and inflexible. The humanistic approach, on the other hand, focuses on affective, emotional, and intellectual learning experiences. But it seems to…

  8. Reflections on Narrative Approaches to Moral Development.

    Science.gov (United States)

    Lourenco, Orlando

    1996-01-01

    Compares narrative approaches to Kohlberg's theory of moral development along five dimensions: values relevance, legitimacy, universality, rationality, and commensurability. Argues that, contrary to Kohlberg's theory, narrative approaches may lead to contradiction in epistemology, nihilism in moral choices, and opportunism in relationships.…

  9. Model-based development and testing of advertising messages: A comparative study of two campaign proposals based on the MECCAS model and a conventional approach

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino

    1. Traditionally the development of advertising messages has been based on "creative independence", sometimes catalysed by inductively generated empirical data. Due to the recent intensified focus on advertising effectiveness, this state of affair is now beginning to change. 2. Implementing...... theoretically valid and comprehensible guidelines for message development potentially enhances the effects of advertising messages and improves the possibility of measuring such effects. Moreover, such guidelines also have potential implications for the managerial communication processes (client......-agency and intra-agency) involved in the development of advertising messages. 3. The purpose of the study described in this paper is to compare the development and effects of two campaign proposals, with the common aim of increasing the consumption of apples among young Danes (18 to 35 years of age). One...

  10. Development of more generalized and model-independent approaches in the search for supersymmetry in RPV scenarios with 4 leptons in the final state at ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Bechtle, Philip; Desch, Klaus; Leininger, Jonas [University of Bonn (Germany)

    2013-07-01

    The ongoing search for a supersymmetric extension of the Standard Model (SM) is expected to be speed up by the use of Simplified Models rather than fully-fledged ones like the MSSM. Simplified Models in general come with the advantage of a smaller parameter space while in the presented case the term refers to particular model-independent supersymmetric decay chains. The benefit of this approach is the versatility it offers: one can look for these decay chains independent of any model. Starting from a RPV-MSSM-motivated choice of decay chains involving 4 leptons, the method of parameter reduction towards an as simple as possible model structure is described. Moreover, possible final parametrizations and a resulting parameter grid are presented and discussed. Based on these grids, the setting of cross section limits on these decay chains and thus on SUSY models in which they are realized is a future prospect.

  11. MAIN APPROACHES TO BUSINESS DEVELOPMENT STRATEGY FORMATION

    Directory of Open Access Journals (Sweden)

    D. B. Smirnov

    2015-01-01

    Full Text Available Article tasks: defi ne main approaches to business development strategy formation. Methodology: methodological basis includes systemic, replication and dialectic general scientifi c approaches. Results: it is established that the activity approach as a leading methodology of strategy development assumes correlation between the activity category and the concepts: needs, interests, incentives, goals, refl ection (evaluation, and self-development. Systemic approach assumes to consider strategy as a system having a defi nite structure and interconnections within the system components. Conclusions/relevance: for Russian businesses the main goal in the management system is not a prompt response to current environmental changes, but formation of a strategic vision of the business’ future, elaboration of a fl exible and viable development strategy, to foresee tactical and strategic threats for the business activity, to remove them timely, as well as to use strategic management ideas in practice for sustainable growth.

  12. Developing an Intuitive Approach to Moles.

    Science.gov (United States)

    Wakeley, Dawn M.; de Grys, Hans

    2000-01-01

    Explains the concept of mole and presents a teaching approach in which students can experiment with atoms and develop an understanding of mass ratios. Presents 10 examples of chemistry problems involving moles and unit conversations. (YDS)

  13. A meta-composite software development approach for translational research.

    Science.gov (United States)

    Sadasivam, Rajani S; Tanik, Murat M

    2013-06-01

    Translational researchers conduct research in a highly data-intensive and continuously changing environment and need to use multiple, disparate tools to achieve their goals. These researchers would greatly benefit from meta-composite software development or the ability to continuously compose and recompose tools together in response to their ever-changing needs. However, the available tools are largely disconnected, and current software approaches are inefficient and ineffective in their support for meta-composite software development. Building on the composite services development approach, the de facto standard for developing integrated software systems, we propose a concept-map and agent-based meta-composite software development approach. A crucial step in composite services development is the modeling of users' needs as processes, which can then be specified in an executable format for system composition. We have two key innovations. First, our approach allows researchers (who understand their needs best) instead of technicians to take a leadership role in the development of process models, reducing inefficiencies and errors. A second innovation is that our approach also allows for modeling of complex user interactions as part of the process, overcoming the technical limitations of current tools. We demonstrate the feasibility of our approach using a real-world translational research use case. We also present results of usability studies evaluating our approach for future refinements.

  14. Multiscale Model Approach for Magnetization Dynamics Simulations

    CERN Document Server

    De Lucia, Andrea; Tretiakov, Oleg A; Kläui, Mathias

    2016-01-01

    Simulations of magnetization dynamics in a multiscale environment enable rapid evaluation of the Landau-Lifshitz-Gilbert equation in a mesoscopic sample with nanoscopic accuracy in areas where such accuracy is required. We have developed a multiscale magnetization dynamics simulation approach that can be applied to large systems with spin structures that vary locally on small length scales. To implement this, the conventional micromagnetic simulation framework has been expanded to include a multiscale solving routine. The software selectively simulates different regions of a ferromagnetic sample according to the spin structures located within in order to employ a suitable discretization and use either a micromagnetic or an atomistic model. To demonstrate the validity of the multiscale approach, we simulate the spin wave transmission across the regions simulated with the two different models and different discretizations. We find that the interface between the regions is fully transparent for spin waves with f...

  15. Model-based development and testing of advertising messages: A comparative study of two campaign proposals based on the MECCAS model and a conventional approach

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino

    2001-01-01

    Traditionally, the development of advertising messages has been based on "creative independence", sometimes catalysed by inductively generated empirical data. Due to the recent intensified focus on advertising effectiveness, this state of affairs is beginning to change. The purpose of the study....... The comparison involved the efficiency of the managerial communication taking place in the message development process as well as target group communication effects. The managerial communication was studied by interviews with the involved advertising agency (Midtmarketing, Ikast, Denmark) and client staff...... described in this article is to compare the development and effects of two campaign proposals, with the sommon aim of increasing the consumption of apples among young Danes (18 to 35 years of age). One of the proposals is the result of an inductive-creative process, while the other is base on the MECCAS...

  16. Interfacial Fluid Mechanics A Mathematical Modeling Approach

    CERN Document Server

    Ajaev, Vladimir S

    2012-01-01

    Interfacial Fluid Mechanics: A Mathematical Modeling Approach provides an introduction to mathematical models of viscous flow used in rapidly developing fields of microfluidics and microscale heat transfer. The basic physical effects are first introduced in the context of simple configurations and their relative importance in typical microscale applications is discussed. Then,several configurations of importance to microfluidics, most notably thin films/droplets on substrates and confined bubbles, are discussed in detail.  Topics from current research on electrokinetic phenomena, liquid flow near structured solid surfaces, evaporation/condensation, and surfactant phenomena are discussed in the later chapters. This book also:  Discusses mathematical models in the context of actual applications such as electrowetting Includes unique material on fluid flow near structured surfaces and phase change phenomena Shows readers how to solve modeling problems related to microscale multiphase flows Interfacial Fluid Me...

  17. Underground structures increasing the intrinsic vulnerability of urban groundwater: Sensitivity analysis and development of an empirical law based on a groundwater age modelling approach

    Science.gov (United States)

    Attard, Guillaume; Rossier, Yvan; Eisenlohr, Laurent

    2017-09-01

    In a previous paper published in Journal of Hydrology, it was shown that underground structures are responsible for a mixing process between shallow and deep groundwater that can favour the spreading of urban contamination. In this paper, the impact of underground structures on the intrinsic vulnerability of urban aquifers was investigated. A sensitivity analysis was performed using a 2D deterministic modelling approach based on the reservoir theory generalized to hydrodispersive systems to better understand this mixing phenomenon and the mixing affected zone (MAZ) caused by underground structures. It was shown that the maximal extent of the MAZ caused by an underground structure is reached approximately 20 years after construction. Consequently, underground structures represent a long-term threat for deep aquifer reservoirs. Regarding the construction process, draining operations have a major impact and favour large-scale mixing between shallow and deep groundwater. Consequently, dewatering should be reduced and enclosed as much as possible. The role played by underground structures' dimensions was assessed. The obstruction of the first aquifer layer caused by construction has the greatest influence on the MAZ. The cumulative impact of several underground structures was assessed. It was shown that the total MAZ area increases linearly with underground structures' density. The role played by materials' properties and hydraulic gradient were assessed. Hydraulic conductivity, anisotropy and porosity have the strongest influence on the development of MAZ. Finally, an empirical law was derived to estimate the MAZ caused by an underground structure in a bi-layered aquifer under unconfined conditions. This empirical law, based on the results of the sensitivity analysis developed in this paper, allows for the estimation of MAZ dimensions under known material properties and underground structure dimensions. This empirical law can help urban planners assess the area of

  18. Java Applications Development Based on Component and Metacomponent Approach

    OpenAIRE

    Danijel Radošević; Mario Konecki; Tihomir Orehovački

    2008-01-01

    Component based modeling offers new and improved approach to design, construction, implementation and evolution of software applications development. This kind of software applications development is usually represented by appropriate component model/diagram. UML, for example, offers component diagram for representation of this kind of model. On the other hand, metacomponents usage offers some new features which hardly could be achieved by using generic components. Firstly, implementation of ...

  19. A model-driven approach for developing three-dimensional user interfaces of information systems in a principle-based way

    OpenAIRE

    Gonzalez Calleros, Juan Manuel

    2010-01-01

    Since many years, 3D interactive systems have demonstrated some benefits in reproducing adequately the reality, in improving it, and even in augmenting it by providing the user with unprecedented actions. 3D User Interfaces (UIs) are becoming the primary subject of interest of a growing community of researchers and developers adopting different approaches for specifying and creating 3DUIs. Providing development methods and software support for 3DUIs is a complex problem. In this thesis, we...

  20. The Formal Approach to Computer Game Rule Development Automation

    OpenAIRE

    Elena, A

    2009-01-01

    Computer game rules development is one of the weakly automated tasks in game development. This paper gives an overview of the ongoing research project which deals with automation of rules development for turn-based strategy computer games. Rules are the basic elements of these games. This paper proposes a new approach to automation including visual formal rules model creation, model verification and modelbased code generation.

  1. Systematic approach to MIS model creation

    Directory of Open Access Journals (Sweden)

    Macura Perica

    2004-01-01

    Full Text Available In this paper-work, by application of basic principles of general theory of system (systematic approach, we have formulated a model of marketing information system. Bases for research were basic characteristics of systematic approach and marketing system. Informational base for management of marketing system, i.e. marketing instruments was presented in a way that the most important information for decision making were listed per individual marketing mix instruments. In projected model of marketing information system, information listed in this way create a base for establishing of data bases, i.e. bases of information (data bases of: product, price, distribution, promotion. This paper-work gives basic preconditions for formulation and functioning of the model. Model was presented by explication of elements of its structure (environment, data bases operators, analysts of information system, decision makers - managers, i.e. input, process, output, feedback and relations between these elements which are necessary for its optimal functioning. Beside that, here are basic elements for implementation of the model into business system, as well as conditions for its efficient functioning and development.

  2. Validation of Modeling Flow Approaching Navigation Locks

    Science.gov (United States)

    2013-08-01

    instrumentation, direction vernier . ........................................................................ 8  Figure 11. Plan A lock approach, upstream approach...13-9 8 Figure 9. Tools and instrumentation, bracket attached to rail. Figure 10. Tools and instrumentation, direction vernier . Numerical model

  3. Toward a Cooperative Experimental System Development Approach

    DEFF Research Database (Denmark)

    1997-01-01

    This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can...... be based solely on observation and detached reflection; prototyping methods often have a narrow focus on the technical construction of various kinds of prototypes; Participatory Design techniques—including the Scandinavian Cooperative Design (CD) approaches—seldom go beyond the early analysis......, however, not limited to this development context, it may be applied for in-house or contract development as well. In system development, particularly in cooperative and experimental system development, we argue that it is necessary to analytically separate the abstract concerns, e.g. analysis, design...

  4. Holistic and Ecological Approaches in Talent Development

    DEFF Research Database (Denmark)

    Henriksen, Kristoffer

    Research on athletic talent has evolved from talent detection to talent development with both perspectives focusing on an individual athlete. This individual focus has been mirrored in the applied work of the sport psychology practitioner in youth competitive sport who has primarily focused...... on equipping individual athletes with the psychosocial skills required in a sport career. In contrast, the holistic ecological approach (HEA) to talent development in sport (Henriksen, Stambulova & Roessler, 2010) acknowledges the role of the overall environment in athletes’ development. The HEA integrates...... the somewhat opposing talent discovery and development approaches by focusing on how an environment manages the balance between these two, and how this balance becomes a part of the environment’s identity. Ecological perspectives on talent development hold rich insights for developing theories, research...

  5. Product Development Process Modeling

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The use of Concurrent Engineering and other modern methods of product development and maintenance require that a large number of time-overlapped "processes" be performed by many people. However, successfully describing and optimizing these processes are becoming even more difficult to achieve. The perspective of industrial process theory (the definition of process) and the perspective of process implementation (process transition, accumulation, and inter-operations between processes) are used to survey the method used to build one base model (multi-view) process model.

  6. Recommended approach to software development, revision 3

    Science.gov (United States)

    Landis, Linda; Waligora, Sharon; Mcgarry, Frank; Pajerski, Rose; Stark, Mike; Johnson, Kevin Orlin; Cover, Donna

    1992-01-01

    Guidelines for an organized, disciplined approach to software development that is based on studies conducted by the Software Engineering Laboratory (SEL) since 1976 are presented. It describes methods and practices for each phase of a software development life cycle that starts with requirements definition and ends with acceptance testing. For each defined life cycle phase, guidelines for the development process and its management, and for the products produced and their reviews are presented.

  7. Multi Sensor Approach to Address Sustainable Development

    Science.gov (United States)

    Habib, Shahid

    2007-01-01

    The main objectives of Earth Science research are many folds: to understand how does this planet operates, can we model her operation and eventually develop the capability to predict such changes. However, the underlying goals of this work are to eventually serve the humanity in providing societal benefits. This requires continuous, and detailed observations from many sources in situ, airborne and space. By and large, the space observations are the way to comprehend the global phenomena across continental boundaries and provide credible boundary conditions for the mesoscale studies. This requires a multiple sensors, look angles and measurements over the same spot in accurately solving many problems that may be related to air quality, multi hazard disasters, public health, hydrology and more. Therefore, there are many ways to address these issues and develop joint implementation, data sharing and operating strategies for the benefit of the world community. This is because for large geographical areas or regions and a diverse population, some sound observations, scientific facts and analytical models must support the decision making. This is crucial for the sustainability of vital resources of the world and at the same time to protect the inhabitants, endangered species and the ecology. Needless to say, there is no single sensor, which can answer all such questions effectively. Due to multi sensor approach, it puts a tremendous burden on any single implementing entity in terms of information, knowledge, budget, technology readiness and computational power. And, more importantly, the health of planet Earth and its ability to sustain life is not governed by a single country, but in reality, is everyone's business on this planet. Therefore, with this notion, it is becoming an impractical problem by any single organization/country to bear this colossal responsibility. So far, each developed country within their means has proceeded along satisfactorily in implementing

  8. Multi Sensor Approach to Address Sustainable Development

    Science.gov (United States)

    Habib, Shahid

    2007-01-01

    The main objectives of Earth Science research are many folds: to understand how does this planet operates, can we model her operation and eventually develop the capability to predict such changes. However, the underlying goals of this work are to eventually serve the humanity in providing societal benefits. This requires continuous, and detailed observations from many sources in situ, airborne and space. By and large, the space observations are the way to comprehend the global phenomena across continental boundaries and provide credible boundary conditions for the mesoscale studies. This requires a multiple sensors, look angles and measurements over the same spot in accurately solving many problems that may be related to air quality, multi hazard disasters, public health, hydrology and more. Therefore, there are many ways to address these issues and develop joint implementation, data sharing and operating strategies for the benefit of the world community. This is because for large geographical areas or regions and a diverse population, some sound observations, scientific facts and analytical models must support the decision making. This is crucial for the sustainability of vital resources of the world and at the same time to protect the inhabitants, endangered species and the ecology. Needless to say, there is no single sensor, which can answer all such questions effectively. Due to multi sensor approach, it puts a tremendous burden on any single implementing entity in terms of information, knowledge, budget, technology readiness and computational power. And, more importantly, the health of planet Earth and its ability to sustain life is not governed by a single country, but in reality, is everyone's business on this planet. Therefore, with this notion, it is becoming an impractical problem by any single organization/country to bear this colossal responsibility. So far, each developed country within their means has proceeded along satisfactorily in implementing

  9. Developing an analytical model to increase urban security from the Secured perspective by Designing (SBD Approach using fuzzy AHP method (case study: region 17 of Tehran

    Directory of Open Access Journals (Sweden)

    H. Zabihi

    2013-01-01

    DiscussionThis study follows two targets: First, determining the relative importance of criteria and sub-criteria of SBD approach and second, evaluating urban security in four areas of the case study using the results of the previous step. The proposed fuzzy AHP model to achieve mentioned targets is composed of the following steps:Step 1: Identify the criteria and sub-criteria of each principle of SBD approach. Step 2: Structure the AHP model hierarchically based on the criteria and sub-criteria identified at Step 1Step 3: Determine the priorities of the main principles with respect to the goal by using pairwise comparison matrices (w1. This scale is proposed by Kahraman et al. (Kahraman, 2008 and used for solving fuzzy decision making problems (Dagdeviren & Yüksel, 2008; Kahraman, Ertay, & Buyukozkan, 2006; Tolga, Demircan, & Kahraman, 2005 in the literature. Pairwise comparison matrices of the components imported in Microsoft Excel workspace developed for solving FAHP matrices. Step 4: Determine the local weights of the criteria (w2 and sub-criteria (w3 (Local and alternatives. Step 5: Calculate the global weights for the sub-criteria (w3 (Global. Step 6: Compute the overall weight of each alternative (area and choose the best area. 4– ConclusionThis study has been proposed a hierarchical model to evaluate the rate of environmental security which decomposes the 5 principles of SBD into 12 criteria and 29 sub-criteria. To our best knowledge, this is the first time that factors affecting main principles of SBD are determined and prioritized. This may help urban designers to consider the most important factors affecting crime reduction in their designs and decision makings.This model is based on determining the most important factors affecting 5 principles of SBD which can lead to urban security in the case study. For this purpose, fuzzy AHP method is adopted in order to assess the relative importance of the factors and sub factors of the model. This method has the ability

  10. Integrated Computational Model Development

    Science.gov (United States)

    2014-03-01

    68.5%, 9.6% and 21.9%, respectively. The alloy density and Vickers microhardness were ρ = 8.23 ± 0.01 g/cm3 and Hv = 5288 ± 1 MPa. [3...and 3-D. Techniques to mechanically test materials at smaller scales were developed to better inform the deformation models. Also methods were...situ microscale tension testing technique was adapted to enable microscale fatigue testing on tensile dog-bone specimens. Microscale tensile fatigue

  11. Regularization of turbulence - a comprehensive modeling approach

    Science.gov (United States)

    Geurts, B. J.

    2011-12-01

    Turbulence readily arises in numerous flows in nature and technology. The large number of degrees of freedom of turbulence poses serious challenges to numerical approaches aimed at simulating and controlling such flows. While the Navier-Stokes equations are commonly accepted to precisely describe fluid turbulence, alternative coarsened descriptions need to be developed to cope with the wide range of length and time scales. These coarsened descriptions are known as large-eddy simulations in which one aims to capture only the primary features of a flow, at considerably reduced computational effort. Such coarsening introduces a closure problem that requires additional phenomenological modeling. A systematic approach to the closure problem, know as regularization modeling, will be reviewed. Its application to multiphase turbulent will be illustrated in which a basic regularization principle is enforced to physically consistently approximate momentum and scalar transport. Examples of Leray and LANS-alpha regularization are discussed in some detail, as are compatible numerical strategies. We illustrate regularization modeling to turbulence under the influence of rotation and buoyancy and investigate the accuracy with which particle-laden flow can be represented. A discussion of the numerical and modeling errors incurred will be given on the basis of homogeneous isotropic turbulence.

  12. Developing a Model Component

    Science.gov (United States)

    Fields, Christina M.

    2013-01-01

    The Spaceport Command and Control System (SCCS) Simulation Computer Software Configuration Item (CSCI) is responsible for providing simulations to support test and verification of SCCS hardware and software. The Universal Coolant Transporter System (UCTS) was a Space Shuttle Orbiter support piece of the Ground Servicing Equipment (GSE). The initial purpose of the UCTS was to provide two support services to the Space Shuttle Orbiter immediately after landing at the Shuttle Landing Facility. The UCTS is designed with the capability of servicing future space vehicles; including all Space Station Requirements necessary for the MPLM Modules. The Simulation uses GSE Models to stand in for the actual systems to support testing of SCCS systems during their development. As an intern at Kennedy Space Center (KSC), my assignment was to develop a model component for the UCTS. I was given a fluid component (dryer) to model in Simulink. I completed training for UNIX and Simulink. The dryer is a Catch All replaceable core type filter-dryer. The filter-dryer provides maximum protection for the thermostatic expansion valve and solenoid valve from dirt that may be in the system. The filter-dryer also protects the valves from freezing up. I researched fluid dynamics to understand the function of my component. The filter-dryer was modeled by determining affects it has on the pressure and velocity of the system. I used Bernoulli's Equation to calculate the pressure and velocity differential through the dryer. I created my filter-dryer model in Simulink and wrote the test script to test the component. I completed component testing and captured test data. The finalized model was sent for peer review for any improvements. I participated in Simulation meetings and was involved in the subsystem design process and team collaborations. I gained valuable work experience and insight into a career path as an engineer.

  13. Teacher Professional Development: International Perspectives and Approaches

    Directory of Open Access Journals (Sweden)

    Alfredo Bautista

    2015-11-01

    Full Text Available Nations around the world are currently embarked in deep reforms of their education systems. There is widespread agreement among policymakers, scholars, and educators that one of the keys for success during these reforms is promoting the professional development (PD of in-service teachers. Every year, governments invest astronomical amounts of money on teacher continuous learning. However, the literature shows that much of the PD offered to teachers is inefficient, having small or no effect on teaching practices and/or student learning. This monograph describes the perspectives and approaches to teacher PD of five nations heavily committed to research and/or practice in this field. Understanding how PD is structured in these nations may guide others in designing more favorable learning opportunities for their teachers. The article from United States provides a general framework regarding the features of high-quality PD and offers examples of recent effective initiatives. The four following articles describe the PD models of Australia, Hong Kong, Finland, and Singapore, among the highest-achievers in education presently. Because teacher continuous learning is a high priority in these nations, strong infrastructures for high-quality PD have been built to meet teachers’ needs and interests. The monograph closes with a contribution from Spain, the country where the journal Psychology, Society and Education is edited. The author discusses the five prior articles and reflects on how the ideas presented could improve the PD currently offered to teachers in other nations, particularly Spain.

  14. Learning Action Models: Qualitative Approach

    NARCIS (Netherlands)

    Bolander, T.; Gierasimczuk, N.; van der Hoek, W.; Holliday, W.H.; Wang, W.-F.

    2015-01-01

    In dynamic epistemic logic, actions are described using action models. In this paper we introduce a framework for studying learnability of action models from observations. We present first results concerning propositional action models. First we check two basic learnability criteria: finite

  15. Java Applications Development Based on Component and Metacomponent Approach

    Directory of Open Access Journals (Sweden)

    Danijel Radošević

    2008-12-01

    Full Text Available Component based modeling offers new and improved approach to design, construction, implementation and evolution of software applications development. This kind of software applications development is usually represented by appropriate component model/diagram. UML, for example, offers component diagram for representation of this kind of model. On the other hand, metacomponents usage offers some new features which hardly could be achieved by using generic components. Firstly, implementation of program properties which are dispersed on different classes and other program units, i.e. aspects, is offered. This implies using automated process of assembling components and their interconnection for building applications, according to appropriate model offered in this paper, which also offers generic components usage. Benefits of this hybrid process are higher flexibility achieved by automated connection process, optimization through selective features inclusion and easier application maintenance and development. In this paper we offer an approach of application development based on hybrid component/metacomponent model. The component model is given by UML diagrams, while the metacomponent model is given by generator scripting model. We explain that hybrid approach on an example of Java Web application development.

  16. Integrated approach to optomechanical system development

    Science.gov (United States)

    Reney, Thomas E.; Wiggins, Richard L.; Comstock, Lovell E.; Santman, Jeffry J.; Woodard, Kenneth S.

    2011-06-01

    Over the past few decades of computer aided engineering growth there has been much more progress in increasing the power and capability of function specific engineering tools (e.g., optical design, finite element analysis, etc.) than in the integration of and communication between these tools. With only a few notable exceptions, such as FEA being imbedded into solid modeling, the communication method between the function specific tools continues to be dominated by translation to neutral data formats (e.g., IGES, STEP) and file transfer. There are a number of problems with this approach. The translation is a serial process where an engineer has to stop at some point in the design, make the neutral file, send that file to the next function, and wait for feedback. The translation through a neutral format is typically one way so the whole translation process has to be repeated when changes are required. Revision tracking of multiple files for each design iteration is both critical and a likely source of errors. Also, as with any translation, some information is always lost or corrupted in the process. This paper describes some progress that has been made in more tightly integrating optical design, mechanical design, fabrication, and testing of optical systems. Tools have been developed that connect CODE V®[1] to SolidWorks®[2] (bidirectional), compensation of diamond turning CNC from interferometric data, slope analysis from interferometer and profilometer data, and other tools for wavefront error compensation, and electronic nulls. Design, machining, testing and inspection efficiency gains are achieved through tools that consume mechanical solid models in their native format.

  17. How can we cope with the complexity of the environment? A "Learning by modelling" approach using qualitative reasoning for developing causal models and simulations with focus on Sustainable River Catchment Management

    Science.gov (United States)

    Poppe, Michaela; Zitek, Andreas; Salles, Paulo; Bredeweg, Bert; Muhar, Susanne

    2010-05-01

    The education system needs strategies to attract future scientists and practitioners. There is an alarming decline in the number of students choosing science subjects. Reasons for this include the perceived complexity and the lack of effective cognitive tools that enable learners to acquire the expertise in a way that fits its qualitative nature. The DynaLearn project utilises a "Learning by modelling" approach to deliver an individualised and engaging cognitive tool for acquiring conceptual knowledge. The modelling approach is based on qualitative reasoning, a research area within artificial intelligence, and allows for capturing and simulating qualitative systems knowledge. Educational activities within the DynaLearn software address topics at different levels of complexity, depending on the educational goals and settings. DynaLearn uses virtual characters in the learning environment as agents for engaging and motivating the students during their modelling exercise. The DynaLearn software represents an interactive learning environment in which learners are in control of their learning activities. The software is able to coach them individually based on their current progress, their knowledge needs and learning goals. Within the project 70 expert models on different environmental issues covering seven core topics (Earth Systems and Resources, The Living World, Human population, Land and Water Use, Energy Resources and Consumption, Pollution, and Global Changes) will be delivered. In the context of the core topic "Land and Water Use" the Institute of Hydrobiology and Aquatic Ecosystem Management has developed a model on Sustainable River Catchment Management. River systems with their catchments have been tremendously altered due to human pressures with serious consequences for the ecological integrity of riverine landscapes. The operation of hydropower plants, the implementation of flood protection measures, the regulation of flow and sediment regime and intensive

  18. APPROACHES TO EMPLOYEE DEVELOPMENT IN CZECH ORGANISATIONS

    Directory of Open Access Journals (Sweden)

    VNOUČKOVÁ, Lucie

    2015-03-01

    Full Text Available Education, development, knowledge management, career development and talent management are currently often discussed themes regarding strategic management of organisations. Those concepts are strategically important. Therefore the aim of the article is to evaluate possibilities of employee education and development and identify main approaches to employee development in Czech organizations. The results are based on a quantitative survey by questionnaire data collection. The results shows that 70% of respondents have possibility of development; 86% uses their skills and abilities and 63% stated that their employer support their development. On the contrary, 27% do not feel any possibility to grow and that may lead to disaffection, loss of production or even to employee turnover. Based on the results of the analysis, employees, who miss adequate level of development are usually key and knowledge employees; it is necessary to support their career plans and development to retain them in organisation.

  19. Learning Actions Models: Qualitative Approach

    DEFF Research Database (Denmark)

    Bolander, Thomas; Gierasimczuk, Nina

    2015-01-01

    —they are identifiable in the limit.We then move on to a particular learning method, which proceeds via restriction of a space of events within a learning-specific action model. This way of learning closely resembles the well-known update method from dynamic epistemic logic. We introduce several different learning......In dynamic epistemic logic, actions are described using action models. In this paper we introduce a framework for studying learnability of action models from observations. We present first results concerning propositional action models. First we check two basic learnability criteria: finite...... identifiability (conclusively inferring the appropriate action model in finite time) and identifiability in the limit (inconclusive convergence to the right action model). We show that deterministic actions are finitely identifiable, while non-deterministic actions require more learning power...

  20. Geometrical approach to fluid models

    NARCIS (Netherlands)

    Kuvshinov, B. N.; Schep, T. J.

    1997-01-01

    Differential geometry based upon the Cartan calculus of differential forms is applied to investigate invariant properties of equations that describe the motion of continuous media. The main feature of this approach is that physical quantities are treated as geometrical objects. The geometrical

  1. Geometrical approach to fluid models

    NARCIS (Netherlands)

    Kuvshinov, B. N.; Schep, T. J.

    1997-01-01

    Differential geometry based upon the Cartan calculus of differential forms is applied to investigate invariant properties of equations that describe the motion of continuous media. The main feature of this approach is that physical quantities are treated as geometrical objects. The geometrical notio

  2. Model based feature fusion approach

    NARCIS (Netherlands)

    Schwering, P.B.W.

    2001-01-01

    In recent years different sensor data fusion approaches have been analyzed and evaluated in the field of mine detection. In various studies comparisons have been made between different techniques. Although claims can be made for advantages for using certain techniques, until now there has been no si

  3. Challenges and opportunities for integrating lake ecosystem modelling approaches

    Science.gov (United States)

    Mooij, Wolf M.; Trolle, Dennis; Jeppesen, Erik; Arhonditsis, George; Belolipetsky, Pavel V.; Chitamwebwa, Deonatus B.R.; Degermendzhy, Andrey G.; DeAngelis, Donald L.; Domis, Lisette N. De Senerpont; Downing, Andrea S.; Elliott, J. Alex; Ruberto, Carlos Ruberto; Gaedke, Ursula; Genova, Svetlana N.; Gulati, Ramesh D.; Hakanson, Lars; Hamilton, David P.; Hipsey, Matthew R.; Hoen, Jochem 't; Hulsmann, Stephan; Los, F. Hans; Makler-Pick, Vardit; Petzoldt, Thomas; Prokopkin, Igor G.; Rinke, Karsten; Schep, Sebastiaan A.; Tominaga, Koji; Van Dam, Anne A.; Van Nes, Egbert H.; Wells, Scott A.; Janse, Jan H.

    2010-01-01

    A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing the wheel'). The other challenge is to avoid focusing on only one type of model, while ignoring new and diverse approaches that have become available ('having tunnel vision'). In this paper, we aim at improving the awareness of existing models and knowledge of concurrent approaches in lake ecosystem modelling, without covering all possible model tools and avenues. First, we present a broad variety of modelling approaches. To illustrate these approaches, we give brief descriptions of rather arbitrarily selected sets of specific models. We deal with static models (steady state and regression models), complex dynamic models (CAEDYM, CE-QUAL-W2, Delft 3D-ECO, LakeMab, LakeWeb, MyLake, PCLake, PROTECH, SALMO), structurally dynamic models and minimal dynamic models. We also discuss a group of approaches that could all be classified as individual based: super-individual models (Piscator, Charisma), physiologically structured models, stage-structured models and trait-based models. We briefly mention genetic algorithms, neural networks, Kalman filters and fuzzy logic. Thereafter, we zoom in, as an in-depth example, on the multi-decadal development and application of the lake ecosystem model PCLake and related models (PCLake Metamodel, Lake Shira Model, IPH-TRIM3D-PCLake). In the discussion, we argue that while the historical development of each approach and model is understandable given its 'leading principle', there are many opportunities for combining approaches. We take the point of view that a single 'right' approach does not exist and should not be strived for. Instead, multiple modelling approaches, applied concurrently to a given problem, can help develop an integrative

  4. Merging Digital Surface Models Implementing Bayesian Approaches

    Science.gov (United States)

    Sadeq, H.; Drummond, J.; Li, Z.

    2016-06-01

    In this research different DSMs from different sources have been merged. The merging is based on a probabilistic model using a Bayesian Approach. The implemented data have been sourced from very high resolution satellite imagery sensors (e.g. WorldView-1 and Pleiades). It is deemed preferable to use a Bayesian Approach when the data obtained from the sensors are limited and it is difficult to obtain many measurements or it would be very costly, thus the problem of the lack of data can be solved by introducing a priori estimations of data. To infer the prior data, it is assumed that the roofs of the buildings are specified as smooth, and for that purpose local entropy has been implemented. In addition to the a priori estimations, GNSS RTK measurements have been collected in the field which are used as check points to assess the quality of the DSMs and to validate the merging result. The model has been applied in the West-End of Glasgow containing different kinds of buildings, such as flat roofed and hipped roofed buildings. Both quantitative and qualitative methods have been employed to validate the merged DSM. The validation results have shown that the model was successfully able to improve the quality of the DSMs and improving some characteristics such as the roof surfaces, which consequently led to better representations. In addition to that, the developed model has been compared with the well established Maximum Likelihood model and showed similar quantitative statistical results and better qualitative results. Although the proposed model has been applied on DSMs that were derived from satellite imagery, it can be applied to any other sourced DSMs.

  5. MERGING DIGITAL SURFACE MODELS IMPLEMENTING BAYESIAN APPROACHES

    Directory of Open Access Journals (Sweden)

    H. Sadeq

    2016-06-01

    Full Text Available In this research different DSMs from different sources have been merged. The merging is based on a probabilistic model using a Bayesian Approach. The implemented data have been sourced from very high resolution satellite imagery sensors (e.g. WorldView-1 and Pleiades. It is deemed preferable to use a Bayesian Approach when the data obtained from the sensors are limited and it is difficult to obtain many measurements or it would be very costly, thus the problem of the lack of data can be solved by introducing a priori estimations of data. To infer the prior data, it is assumed that the roofs of the buildings are specified as smooth, and for that purpose local entropy has been implemented. In addition to the a priori estimations, GNSS RTK measurements have been collected in the field which are used as check points to assess the quality of the DSMs and to validate the merging result. The model has been applied in the West-End of Glasgow containing different kinds of buildings, such as flat roofed and hipped roofed buildings. Both quantitative and qualitative methods have been employed to validate the merged DSM. The validation results have shown that the model was successfully able to improve the quality of the DSMs and improving some characteristics such as the roof surfaces, which consequently led to better representations. In addition to that, the developed model has been compared with the well established Maximum Likelihood model and showed similar quantitative statistical results and better qualitative results. Although the proposed model has been applied on DSMs that were derived from satellite imagery, it can be applied to any other sourced DSMs.

  6. Global energy modeling - A biophysical approach

    Energy Technology Data Exchange (ETDEWEB)

    Dale, Michael

    2010-09-15

    This paper contrasts the standard economic approach to energy modelling with energy models using a biophysical approach. Neither of these approaches includes changing energy-returns-on-investment (EROI) due to declining resource quality or the capital intensive nature of renewable energy sources. Both of these factors will become increasingly important in the future. An extension to the biophysical approach is outlined which encompasses a dynamic EROI function that explicitly incorporates technological learning. The model is used to explore several scenarios of long-term future energy supply especially concerning the global transition to renewable energy sources in the quest for a sustainable energy system.

  7. Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

    OpenAIRE

    2014-01-01

    The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening model in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops lung tumors spontaneously. Moreover, there is a considerable gap in our understanding of the underlying mechanisms of pulmonary chemical carcinogenesis in the A/J mouse. Therefore, we examined the differences between spontaneous and cigarette smoke-rela...

  8. Recent Developments in the PQCD Approach

    CERN Document Server

    Mishima, S

    2007-01-01

    We review recent developments in the perturbative QCD approach to exclusive hadronic B meson decays. We discuss the important next-to-leading-order corrections to B -> pi K, pi pi, and the penguin-dominated B -> PV modes, where P (V) is a pseudo-scalar (vector) meson.

  9. Design for Development: A Capability Approach

    NARCIS (Netherlands)

    Oosterlaken, I.

    2009-01-01

    In this article I suggest a ‘capability approach’ towards designing for society, and particularly, the world’s poor. I will explain that this approach assigns a central place to human capabilities in our discussions of justice and development and criticizes a focus on utility or preference satisfact

  10. Nuclear level density: Shell-model approach

    Science.gov (United States)

    Sen'kov, Roman; Zelevinsky, Vladimir

    2016-06-01

    Knowledge of the nuclear level density is necessary for understanding various reactions, including those in the stellar environment. Usually the combinatorics of a Fermi gas plus pairing is used for finding the level density. Recently a practical algorithm avoiding diagonalization of huge matrices was developed for calculating the density of many-body nuclear energy levels with certain quantum numbers for a full shell-model Hamiltonian. The underlying physics is that of quantum chaos and intrinsic thermalization in a closed system of interacting particles. We briefly explain this algorithm and, when possible, demonstrate the agreement of the results with those derived from exact diagonalization. The resulting level density is much smoother than that coming from conventional mean-field combinatorics. We study the role of various components of residual interactions in the process of thermalization, stressing the influence of incoherent collision-like processes. The shell-model results for the traditionally used parameters are also compared with standard phenomenological approaches.

  11. Determinants and development of a web-based child mortality prediction model in resource-limited settings: A data mining approach.

    Science.gov (United States)

    Tesfaye, Brook; Atique, Suleman; Elias, Noah; Dibaba, Legesse; Shabbir, Syed-Abdul; Kebede, Mihiretu

    2017-03-01

    Improving child health and reducing child mortality rate are key health priorities in developing countries. This study aimed to identify determinant sand develop, a web-based child mortality prediction model in Ethiopian local language using classification data mining algorithm. Decision tree (using J48 algorithm) and rule induction (using PART algorithm) techniques were applied on 11,654 records of Ethiopian demographic and health survey data. Waikato Environment for Knowledge Analysis (WEKA) for windows version 3.6.8 was used to develop optimal models. 8157 (70%) records were randomly allocated to training group for model building while; the remaining 3496 (30%) records were allocated as the test group for model validation. The validation of the model was assessed using accuracy, sensitivity, specificity and area under Receiver Operating Characteristics (ROC) curve. Using Statistical Package for Social Sciences (SPSS) version 20.0; logistic regressions and Odds Ratio (OR) with 95% Confidence Interval (CI) was used to identify determinants of child mortality. The child mortality rate was 72 deaths per 1000 live births. Breast-feeding (AOR= 1.46, (95% CI [1.22. 1.75]), maternal education (AOR= 1.40, 95% CI [1.11, 1.81]), family planning (AOR= 1.21, [1.08, 1.43]), preceding birth interval (AOR= 4.90, [2.94, 8.15]), presence of diarrhea (AOR= 1.54, 95% CI [1.32, 1.66]), father's education (AOR= 1.4, 95% CI [1.04, 1.78]), low birth weight (AOR= 1.2, 95% CI [0.98, 1.51]) and, age of the mother at first birth (AOR= 1.42, [1.01-1.89]) were found to be determinants for child mortality. The J48 model had better performance, accuracy (94.3%), sensitivity (93.8%), specificity (94.3%), Positive Predictive Value (PPV) (92.2%), Negative Predictive Value (NPV) (94.5%) and, the area under ROC (94.8%). Subsequent to developing an optimal prediction model, we relied on this model to develop a web-based application system for child mortality prediction. In this study

  12. The chronic diseases modelling approach

    NARCIS (Netherlands)

    Hoogenveen RT; Hollander AEM de; Genugten MLL van; CCM

    1998-01-01

    A mathematical model structure is described that can be used to simulate the changes of the Dutch public health state over time. The model is based on the concept of demographic and epidemiologic processes (events) and is mathematically based on the lifetable method. The population is divided over s

  13. A systematic approach to behavior change interventions for the water and sanitation sector in developing countries: a conceptual model, a review, and a guideline.

    Science.gov (United States)

    Mosler, Hans-Joachim

    2012-01-01

    Public health practitioners increasingly agree that it is not enough to provide people with water and sanitation hardware. Numerous approaches are used to tackle the "software" which means to ensure behavior change necessary to come along with the sanitation hardware. A review of these approaches reveals several shortcomings, most importantly that they do not provide behavioral change interventions which correspond to psychological factors to be changed. This article presents a sound psychological model, which postulates that for the formation of new habitual behavior, five blocks of factors must be positive with regard to the new behavior: risk factors, attitudinal factors, normative factors, ability factors, and self-regulation factors. Standardized tools for measuring the factors in face-to-face interviews are presented, and behavioral interventions are provided for each factor block. A statistical analysis method is presented, which allows the determination of the improvement potential of each factor.

  14. A Bayesian modeling approach for generalized semiparametric structural equation models.

    Science.gov (United States)

    Song, Xin-Yuan; Lu, Zhao-Hua; Cai, Jing-Heng; Ip, Edward Hak-Sing

    2013-10-01

    In behavioral, biomedical, and psychological studies, structural equation models (SEMs) have been widely used for assessing relationships between latent variables. Regression-type structural models based on parametric functions are often used for such purposes. In many applications, however, parametric SEMs are not adequate to capture subtle patterns in the functions over the entire range of the predictor variable. A different but equally important limitation of traditional parametric SEMs is that they are not designed to handle mixed data types-continuous, count, ordered, and unordered categorical. This paper develops a generalized semiparametric SEM that is able to handle mixed data types and to simultaneously model different functional relationships among latent variables. A structural equation of the proposed SEM is formulated using a series of unspecified smooth functions. The Bayesian P-splines approach and Markov chain Monte Carlo methods are developed to estimate the smooth functions and the unknown parameters. Moreover, we examine the relative benefits of semiparametric modeling over parametric modeling using a Bayesian model-comparison statistic, called the complete deviance information criterion (DIC). The performance of the developed methodology is evaluated using a simulation study. To illustrate the method, we used a data set derived from the National Longitudinal Survey of Youth.

  15. Approaches and models of intercultural education

    Directory of Open Access Journals (Sweden)

    Iván Manuel Sánchez Fontalvo

    2013-10-01

    Full Text Available Needed to be aware of the need to build an intercultural society, awareness must be assumed in all social spheres, where stands the role play education. A role of transcendental, since it must promote educational spaces to form people with virtues and powers that allow them to live together / as in multicultural contexts and social diversities (sometimes uneven in an increasingly globalized and interconnected world, and foster the development of feelings of civic belonging shared before the neighborhood, city, region and country, allowing them concern and critical judgement to marginalization, poverty, misery and inequitable distribution of wealth, causes of structural violence, but at the same time, wanting to work for the welfare and transformation of these scenarios. Since these budgets, it is important to know the approaches and models of intercultural education that have been developed so far, analysing their impact on the contexts educational where apply.   

  16. Learning Actions Models: Qualitative Approach

    DEFF Research Database (Denmark)

    Bolander, Thomas; Gierasimczuk, Nina

    2015-01-01

    identifiability (conclusively inferring the appropriate action model in finite time) and identifiability in the limit (inconclusive convergence to the right action model). We show that deterministic actions are finitely identifiable, while non-deterministic actions require more learning power......—they are identifiable in the limit.We then move on to a particular learning method, which proceeds via restriction of a space of events within a learning-specific action model. This way of learning closely resembles the well-known update method from dynamic epistemic logic. We introduce several different learning...

  17. Pattern-based approach for logical traffic isolation forensic modelling

    CSIR Research Space (South Africa)

    Dlamini, I

    2009-08-01

    Full Text Available The use of design patterns usually changes the approach of software design and makes software development relatively easy. This paper extends work on a forensic model for Logical Traffic Isolation (LTI) based on Differentiated Services (Diff...

  18. Developing integrated care. Towards a development model for integrated care

    OpenAIRE

    Minkman, Mirella M.N

    2012-01-01

    textabstractThe thesis adresses the phenomenon of integrated care. The implementation of integrated care for patients with a stroke or dementia is studied. Because a generic quality management model for integrated care is lacking, the study works towards building a development model for integrated care. Based on a systematic approach in which a literature study, a delphi study, a concept mapping study and questionnaire research are combined, a development model for integrated care is created....

  19. The Bayesian Revolution Approaches Psychological Development

    Science.gov (United States)

    Shultz, Thomas R.

    2007-01-01

    This commentary reviews five articles that apply Bayesian ideas to psychological development, some with psychology experiments, some with computational modeling, and some with both experiments and modeling. The reviewed work extends the current Bayesian revolution into tasks often studied in children, such as causal learning and word learning, and…

  20. Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: I. Data generation in a small fish model

    Science.gov (United States)

    Adaptive or compensatory responses to chemical exposure can significantly influence in vivo concentration-duration-response relationships. The aim of this study was to provide data to support development of a computational dynamic model of the hypothalamic-pituitary-gonadal axis ...

  1. MDA based-approach for UML Models Complete Comparison

    CERN Document Server

    Chaouni, Samia Benabdellah; Mouline, Salma

    2011-01-01

    If a modeling task is distributed, it will frequently be necessary to integrate models developed by different team members. Problems occur in the models integration step and particularly, in the comparison phase of the integration. This issue had been discussed in several domains and various models. However, previous approaches have not correctly handled the semantic comparison. In the current paper, we provide a MDA-based approach for models comparison which aims at comparing UML models. We develop an hybrid approach which takes into account syntactic, semantic and structural comparison aspects. For this purpose, we use the domain ontology as well as other resources such as dictionaries. We propose a decision support system which permits the user to validate (or not) correspondences extracted in the comparison phase. For implementation, we propose an extension of the generic correspondence metamodel AMW in order to transform UML models to the correspondence model.

  2. Adapting the innovation systems approach to agricultural development in Vietnam

    DEFF Research Database (Denmark)

    Friederichsen, Rupert; Thai, Thi Minh; Neef, Andreas

    2013-01-01

    Competing models of innovation informing agricultural extension, such as transfer of technology, participatory extension and technology development, and innovation systems have been proposed over the last decades. These approaches are often presented as antagonistic or even mutually exclusive...... is broadly appropriate for analyzing the Vietnamese case, but that the IS approach in the contemporary Vietnamese context requires adaptation for taking into account the blurred line between private and state sectors, and recognizing the hegemonic position of state-based networks. Improving extensionists...

  3. Development of a nanogel formulation for transdermal delivery of tenoxicam: a pharmacokinetic-pharmacodynamic modeling approach for quantitative prediction of skin absorption.

    Science.gov (United States)

    Elkomy, Mohammed H; El Menshawe, Shahira F; Eid, Hussein M; Ali, Ahmed M A

    2017-04-01

    This study investigates potentials of solid lipid nanoparticles (SLN)-based gel for transdermal delivery of tenoxicam (TNX) and describes a pharmacokinetic-pharmacodynamic (PK-PD) modeling approach for predicting concentration-time profile in skin. A 2(3) factorial design was adopted to study the effect of formulation factors on SLN properties and determine the optimal formulation. SLN-gel tolerability was investigated using rabbit skin irritation test. Its anti-inflammatory activity was assessed by carrageenan-induced rat paw edema test. A published Hill model for in vitro inhibition of COX-2 enzyme was fitted to edema inhibition data. Concentration in skin was represented as a linear spline function and coefficients were estimated using non-linear regression. Uncertainty in predicted concentrations was assessed using Monte Carlo simulations. The optimized SLN was spherical vesicles (58.1 ± 3.1 nm) with adequate entrapment efficiency (69.6 ± 2.6%). The SLN-gel formulation was well-tolerated. It increased TNX activity and skin level by 40 ± 13.5, and 227 ± 116%, respectively. Average Cmax and AUC0-24 predicted by the model were 2- and 3.6-folds higher than the corresponding values computed using in vitro permeability data. SLN-gel is a safe and efficient carrier for TNX across skin in the treatment of inflammatory disorders. PK-PD modeling is a promising approach for indirect quantitation of skin deposition from PD activity data.

  4. Comparing Two Approaches for Engineering Education Development

    DEFF Research Database (Denmark)

    Edström, Kristina; Kolmos, Anette

    2012-01-01

    and differences. CDIO and PBL will each be defined and compared in terms of the original need analysis, underlying educational philosophy and the essentials of the respective approaches to engineering education. In these respects we see many similarities. Circumstances that explain differences in history...... can learn from the other, as well as provide a chart for anyone who wishes to learn about any of these models. As a conclusion, some observations on common lessons learned will be made....

  5. Approaches to Sustainable Development in Contemporary Museology

    Directory of Open Access Journals (Sweden)

    Irene Campolmi

    2013-05-01

    Full Text Available Sustainable development has become a leading value of the 21st century society. Throsby’s and Hutter’s recent studies on inter and intra-generational equity, diversity maintenance and interdependence have demonstrated that sustainability values promote a different perspective on cultural institutions. Particularly, they incite to reorganize the production and consumption patterns, and rethink about the construction of meanings in permanent displays. The paper wants to explore how sustainability principles are an approach to develop a “sustainable museology”, which cares about making visitors more critic and aware of the political, sociological, epistemological and cultural implications that lay behind the making of exhibitions. Museums undertaking a sustainable development of their narrative making processes overpass the Foucauldian idea of art museums as heterotopy, (space of otherness, and approach that of archétopy. This model offers rooms to rethink about narratives as stakeholders’ collective processes capable to “meet the needs of the present without compromising those of the future generations”, as stated in the “Brundtland Commision” Report of 1987. The last display done by the Berlin Neue Nationalgalerie is analysed as a case-study for archétopy. Il paper analizza il concetto di sostenibilità nelle politiche governative dei musei d’arte. Lo studio osserva tale valore da un punto di vista sia teorico che pratico e cita l’esempio dei grandi musei europei, facendo più volte riferimento al caso della Tate Modern di Londra. Se da un lato l’argomento è esplicitamente collegato ai musei d’arte in quanto essi operano per la sostenibilità del bene comune, dall’altro i musei europei hanno basato le proprie politiche culturali adottando il così detto approccio “three bottom” già intrapreso dalle grandi aziende e dalle business companies. Tale approccio si basa sull’elaborazione di politiche attente alla

  6. Science based integrated approach to advanced nuclear fuel development - integrated multi-scale multi-physics hierarchical modeling and simulation framework Part III: cladding

    Energy Technology Data Exchange (ETDEWEB)

    Tome, Carlos N [Los Alamos National Laboratory; Caro, J A [Los Alamos National Laboratory; Lebensohn, R A [Los Alamos National Laboratory; Unal, Cetin [Los Alamos National Laboratory; Arsenlis, A [LLNL; Marian, J [LLNL; Pasamehmetoglu, K [INL

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Reactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems to develop predictive tools is critical. Not only are fabrication and performance models needed to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. In this paper we review the current status of the advanced modeling and simulation of nuclear reactor cladding, with emphasis on what is available and what is to be developed in each scale of the project, how we propose to pass information from one scale to the next, and what experimental information is required for benchmarking and advancing the modeling at each scale level.

  7. Stepwise Approach to Accessible MOOC Development.

    Science.gov (United States)

    Draffan, E A; Wald, Mike; Dickens, Kate; Zimmermann, Gottfried; Kelle, Sebastian; Miesenberger, Klaus; Petz, Andrea

    2015-01-01

    Developing resources for online learning in its many guises and more recently for MOOCs has been discussed across the educational sector, usually by individuals working for one institution or organisation. Rarely are there discussions that highlight the issues of collaborative working on content that is delivered over a period of weeks for a wide range of abilities and skills. In particular there is a reluctance to face the issues presented by barriers to access for those with disabilities and even the issues that could arise should an academic be unable to access the development platform to present content. This paper aims to approach these issues by providing guidance in a series of practical steps that highlight an inclusive design approach.

  8. Szekeres models: a covariant approach

    CERN Document Server

    Apostolopoulos, Pantelis S

    2016-01-01

    We exploit the 1+1+2 formalism to covariantly describe the inhomogeneous and anisotropic Szekeres models. It is shown that an \\emph{average scale length} can be defined \\emph{covariantly} which satisfies a 2d equation of motion driven from the \\emph{effective gravitational mass} (EGM) contained in the dust cloud. The contributions to the EGM are encoded to the energy density of the dust fluid and the free gravitational field $E_{ab}$. In addition the notions of the Apparent and Absolute Apparent Horizons are briefly discussed and we give an alternative gauge-invariant form to define them in terms of the kinematical variables of the spacelike congruences. We argue that the proposed program can be used in order to express the Sachs optical equations in a covariant form and analyze the confrontation of a spatially inhomogeneous irrotational overdense fluid model with the observational data.

  9. Matrix Model Approach to Cosmology

    CERN Document Server

    Chaney, A; Stern, A

    2015-01-01

    We perform a systematic search for rotationally invariant cosmological solutions to matrix models, or more specifically the bosonic sector of Lorentzian IKKT-type matrix models, in dimensions $d$ less than ten, specifically $d=3$ and $d=5$. After taking a continuum (or commutative) limit they yield $d-1$ dimensional space-time surfaces, with an attached Poisson structure, which can be associated with closed, open or static cosmologies. For $d=3$, we obtain recursion relations from which it is possible to generate rotationally invariant matrix solutions which yield open universes in the continuum limit. Specific examples of matrix solutions have also been found which are associated with closed and static two-dimensional space-times in the continuum limit. The solutions provide for a matrix resolution of cosmological singularities. The commutative limit reveals other desirable features, such as a solution describing a smooth transition from an initial inflation to a noninflationary era. Many of the $d=3$ soluti...

  10. Approaching models of nursing from a postmodernist perspective.

    Science.gov (United States)

    Lister, P

    1991-02-01

    This paper explores some questions about the use of models of nursing. These questions make various assumptions about the nature of models of nursing, in general and in particular. Underlying these assumptions are various philosophical positions which are explored through an introduction to postmodernist approaches in philosophical criticism. To illustrate these approaches, a critique of the Roper et al. model is developed, and more general attitudes towards models of nursing are examined. It is suggested that postmodernism offers a challenge to many of the assumptions implicit in models of nursing, and that a greater awareness of these assumptions should lead to nursing care being better informed where such models are in use.

  11. A new approach to adaptive data models

    Directory of Open Access Journals (Sweden)

    Ion LUNGU

    2016-12-01

    Full Text Available Over the last decade, there has been a substantial increase in the volume and complexity of data we collect, store and process. We are now aware of the increasing demand for real time data processing in every continuous business process that evolves within the organization. We witness a shift from a traditional static data approach to a more adaptive model approach. This article aims to extend understanding in the field of data models used in information systems by examining how an adaptive data model approach for managing business processes can help organizations accommodate on the fly and build dynamic capabilities to react in a dynamic environment.

  12. Modeling software behavior a craftsman's approach

    CERN Document Server

    Jorgensen, Paul C

    2009-01-01

    A common problem with most texts on requirements specifications is that they emphasize structural models to the near exclusion of behavioral models-focusing on what the software is, rather than what it does. If they do cover behavioral models, the coverage is brief and usually focused on a single model. Modeling Software Behavior: A Craftsman's Approach provides detailed treatment of various models of software behavior that support early analysis, comprehension, and model-based testing. Based on the popular and continually evolving course on requirements specification models taught by the auth

  13. Heutagogic approach to developing capable learners.

    Science.gov (United States)

    Abraham, Reem Rachel; Komattil, Ramnarayan

    2017-03-01

    The twenty-first century higher education sector has come a long way after undergoing continuous metamorphosis from pedagogy to andragogy. Most of the educational approaches adopted in medical schools are directed towards developing more of competencies and less of capability, which is the ability to use competencies in novel contexts. Competencies alone are not sufficient to thrive in the present day work place as medical profession subsumes complex contexts; it is in this scenario that, medical educators are entrusted with the challenging task of developing "capable learners". In the heutagogical approach, learners are required to decide upon what to learn and how to learn and therefore the control of the learning process is on the learner and the role of the teacher becomes that of a navigator. This paper highlights the current higher educational practices based on heutagogy, considers its application in the context of Problem-based learning and also discusses a few challenges in incorporating this approach in the existing undergraduate medical curriculum. The article proposes the use of social media in order to support learner autonomy, which in turn improves learners' cognitive engagement with content and tasks, thereby assisting the development of attributes associated with capability.

  14. A Process-Discursive Approach to Community Economic Development.

    Science.gov (United States)

    Walter, G. R.

    2003-01-01

    When market-based growth fails to improve community economic development, an alternative approach to economic analysis is a process-discursive method, which considers the roles of human agents and importance of information about reality as experienced by individuals. The process model of community-sensitive transformation is participatory and can…

  15. An approach for the development of visual configuration systems

    DEFF Research Database (Denmark)

    Hvam, Lars; Ladeby, Klaes Rohde

    2007-01-01

    by Centre for Product Modelling (CPM) at The Technical University of Denmark. The approach is based on experiences from a visualization project in co-operation between CPM and the global provider of power protection American Power Conversion (APC). The visual configuration system was developed in 2001...

  16. Science based integrated approach to advanced nuclear fuel development - vision, approach, and overview

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Laboratory; Pasamehmetoglu, Kemal [IDAHO NATIONAL LAB; Carmack, Jon [IDAHO NATIONAL LAB

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Rcactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems is critical. In order to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. The purpose of this paper is to identify the modeling and simulation approach in order to deliver predictive tools for advanced fuels development. The coordination between experimental nuclear fuel design, development technical experts, and computational fuel modeling and simulation technical experts is a critical aspect of the approach and naturally leads to an integrated, goal-oriented science-based R & D approach and strengthens both the experimental and computational efforts. The Advanced Fuels Campaign (AFC) and Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Integrated Performance and Safety Code (IPSC) are working together to determine experimental data and modeling needs. The primary objective of the NEAMS fuels IPSC project is to deliver a coupled, three-dimensional, predictive computational platform for modeling the fabrication and both normal and abnormal operation of nuclear fuel pins and assemblies, applicable to both existing and future reactor fuel designs. The science based program is pursuing the development of an integrated multi-scale and multi-physics modeling and simulation platform for nuclear fuels. This overview paper discusses the vision, goals and approaches how to develop and implement the new approach.

  17. Science based integrated approach to advanced nuclear fuel development - vision, approach, and overview

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Laboratory; Pasamehmetoglu, Kemal [IDAHO NATIONAL LAB; Carmack, Jon [IDAHO NATIONAL LAB

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Rcactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems is critical. In order to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. The purpose of this paper is to identify the modeling and simulation approach in order to deliver predictive tools for advanced fuels development. The coordination between experimental nuclear fuel design, development technical experts, and computational fuel modeling and simulation technical experts is a critical aspect of the approach and naturally leads to an integrated, goal-oriented science-based R & D approach and strengthens both the experimental and computational efforts. The Advanced Fuels Campaign (AFC) and Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Integrated Performance and Safety Code (IPSC) are working together to determine experimental data and modeling needs. The primary objective of the NEAMS fuels IPSC project is to deliver a coupled, three-dimensional, predictive computational platform for modeling the fabrication and both normal and abnormal operation of nuclear fuel pins and assemblies, applicable to both existing and future reactor fuel designs. The science based program is pursuing the development of an integrated multi-scale and multi-physics modeling and simulation platform for nuclear fuels. This overview paper discusses the vision, goals and approaches how to develop and implement the new approach.

  18. Developing multi-tracer approaches to constrain the parameterisation of leaf and soil CO2 and H2O exchange in land surface models

    Science.gov (United States)

    Ogée, Jerome; Wehr, Richard; Commane, Roisin; Launois, Thomas; Meredith, Laura; Munger, Bill; Nelson, David; Saleska, Scott; Zahniser, Mark; Wofsy, Steve; Wingate, Lisa

    2016-04-01

    The net flux of carbon dioxide between the land surface and the atmosphere is dominated by photosynthesis and soil respiration, two of the largest gross CO2 fluxes in the carbon cycle. More robust estimates of these gross fluxes could be obtained from the atmospheric budgets of other valuable tracers, such as carbonyl sulfide (COS) or the carbon and oxygen isotope compositions (δ13C and δ18O) of atmospheric CO2. Over the past decades, the global atmospheric flask network has measured the inter-annual and intra-annual variations in the concentrations of these tracers. However, knowledge gaps and a lack of high-resolution multi-tracer ecosystem-scale measurements have hindered the development of process-based models that can simulate the behaviour of each tracer in response to environmental drivers. We present novel datasets of net ecosystem COS, 13CO2 and CO18O exchange and vertical profile data collected over 3 consecutive growing seasons (2011-2013) at the Harvard forest flux site. We then used the process-based model MuSICA (multi-layer Simulator of the Interactions between vegetation Canopy and the Atmosphere) to include the transport, reaction, diffusion and production of each tracer within the forest and exchanged with the atmosphere. Model simulations over the three years captured well the impact of diurnally and seasonally varying environmental conditions on the net ecosystem exchange of each tracer. The model also captured well the dynamic vertical features of tracer behaviour within the canopy. This unique dataset and model sensitivity analysis highlights the benefit in the collection of multi-tracer high-resolution field datasets and the developement of multi-tracer land surface models to provide valuable constraints on photosynthesis and respiration across scales in the near future.

  19. A New Approach to Development of Composite Web Services

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    With the requirement for complex Web Services steadily increasing, there is a growing interest for reusing basic, existing Web Services to composite new ones. We present a composite Web Services development approach driven by model driven architecture (MDA): using UML(Unified Modeling Language) class diagram to model structure PIM(Plateform Independent Platform) and UML activity diagram to model behavior PIM, then by model transformation converting the PIMs to specific Web Services specification platforms and execution platform to get the corresponding PSMs (platform specific models). The main contributions of this paper are the all-around solution to Web Services composition development and the transformation rules for structure and behavior model of Web Services between PIMs and PSMs.

  20. Modular Modelling and Simulation Approach - Applied to Refrigeration Systems

    DEFF Research Database (Denmark)

    Sørensen, Kresten Kjær; Stoustrup, Jakob

    2008-01-01

    This paper presents an approach to modelling and simulation of the thermal dynamics of a refrigeration system, specifically a reefer container. A modular approach is used and the objective is to increase the speed and flexibility of the developed simulation environment. The refrigeration system...

  1. Phases and Actions of the Evolution of the Concept of Quality in Canada and Australia – A Theoretical Modelling of the Development of Knowledge in Business Performance in the XXI Century - The Approach to Excellence

    Directory of Open Access Journals (Sweden)

    Cristina Raluca Popescu

    2015-05-01

    Full Text Available In the paper “Phases and Actions of the Evolution of the Concept of Quality in Canada and Australia – A Theoretical Modelling of the Development of Knowledge in Business Performance in the XXI Century - The Approach to Excellence” the authors present the basic features of the phases and actions of the evolution of the concept of quality in Canada and Australia, as a theoretical modelling of the development of knowledge in business performance in the XXI century in order to improve the organizational processes so that excellence can be achieved.

  2. Plant development models

    NARCIS (Netherlands)

    Chuine, I.; Garcia de Cortazar-Atauri, I.; Kramer, K.; Hänninen, H.

    2013-01-01

    In this chapter we provide a brief overview of plant phenology modeling, focusing on mechanistic phenological models. After a brief history of plant phenology modeling, we present the different models which have been described in the literature so far and highlight the main differences between them,

  3. Development and Validation of a Gene-Based Model for Outcome Prediction in Germ Cell Tumors Using a Combined Genomic and Expression Profiling Approach.

    Directory of Open Access Journals (Sweden)

    James E Korkola

    Full Text Available Germ Cell Tumors (GCT have a high cure rate, but we currently lack the ability to accurately identify the small subset of patients who will die from their disease. We used a combined genomic and expression profiling approach to identify genomic regions and underlying genes that are predictive of outcome in GCT patients. We performed array-based comparative genomic hybridization (CGH on 53 non-seminomatous GCTs (NSGCTs treated with cisplatin based chemotherapy and defined altered genomic regions using Circular Binary Segmentation. We identified 14 regions associated with two year disease-free survival (2yDFS and 16 regions associated with five year disease-specific survival (5yDSS. From corresponding expression data, we identified 101 probe sets that showed significant changes in expression. We built several models based on these differentially expressed genes, then tested them in an independent validation set of 54 NSGCTs. These predictive models correctly classified outcome in 64-79.6% of patients in the validation set, depending on the endpoint utilized. Survival analysis demonstrated a significant separation of patients with good versus poor predicted outcome when using a combined gene set model. Multivariate analysis using clinical risk classification with the combined gene model indicated that they were independent prognostic markers. This novel set of predictive genes from altered genomic regions is almost entirely independent of our previously identified set of predictive genes for patients with NSGCTs. These genes may aid in the identification of the small subset of patients who are at high risk of poor outcome.

  4. Multicomponent Equilibrium Models for Testing Geothermometry Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Carl D. Palmer; Robert W. Smith; Travis L. McLing

    2013-02-01

    Geothermometry is an important tool for estimating deep reservoir temperature from the geochemical composition of shallower and cooler waters. The underlying assumption of geothermometry is that the waters collected from shallow wells and seeps maintain a chemical signature that reflects equilibrium in the deeper reservoir. Many of the geothermometers used in practice are based on correlation between water temperatures and composition or using thermodynamic calculations based a subset (typically silica, cations or cation ratios) of the dissolved constituents. An alternative approach is to use complete water compositions and equilibrium geochemical modeling to calculate the degree of disequilibrium (saturation index) for large number of potential reservoir minerals as a function of temperature. We have constructed several “forward” geochemical models using The Geochemist’s Workbench to simulate the change in chemical composition of reservoir fluids as they migrate toward the surface. These models explicitly account for the formation (mass and composition) of a steam phase and equilibrium partitioning of volatile components (e.g., CO2, H2S, and H2) into the steam as a result of pressure decreases associated with upward fluid migration from depth. We use the synthetic data generated from these simulations to determine the advantages and limitations of various geothermometry and optimization approaches for estimating the likely conditions (e.g., temperature, pCO2) to which the water was exposed in the deep subsurface. We demonstrate the magnitude of errors that can result from boiling, loss of volatiles, and analytical error from sampling and instrumental analysis. The estimated reservoir temperatures for these scenarios are also compared to conventional geothermometers. These results can help improve estimation of geothermal resource temperature during exploration and early development.

  5. NEUROPSYCHOLOGICAL-DEVELOPMENT APPROACH IN AUTISTIC CHILDREN

    Directory of Open Access Journals (Sweden)

    Dragoslav KOPACHEV

    2005-06-01

    Full Text Available This paper on the children’s autism gives an overview of neuropsychological aspect and in context of the development dynamic approach.The author expresses some characteristics and dilemmas which refer to the Kanner’s autism and Asperger`s syndrome. He presents his own opinion and dilemmas about the every day practice in relation to children’s autism as a pathological disorder which is an expression of pervasive disorder, children’s psychosis or just one development phase in which children are fixated forever.The author thinks children’s autism should be seen in context of the inter-game of biological factors, development and the stress.

  6. A Stigmergy Approach for Open Source Software Developer Community Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Xiaohui [ORNL; Beaver, Justin M [ORNL; Potok, Thomas E [ORNL; Pullum, Laura L [ORNL; Treadwell, Jim N [ORNL

    2009-01-01

    The stigmergy collaboration approach provides a hypothesized explanation about how online groups work together. In this research, we presented a stigmergy approach for building an agent based open source software (OSS) developer community collaboration simulation. We used group of actors who collaborate on OSS projects as our frame of reference and investigated how the choices actors make in contribution their work on the projects determinate the global status of the whole OSS projects. In our simulation, the forum posts and project codes served as the digital pheromone and the modified Pierre-Paul Grasse pheromone model is used for computing developer agent behaviors selection probability.

  7. AN INTEGRATED APPROACH OF INTERPRETIVE STRUCTURAL MODELING (ISM AND ANALYTIC HIERARCHY PROCESS (AHP IN DEVELOPING INSTITUTIONAL SYSTEM OF THE BEEF CATTLE INDUSTRY

    Directory of Open Access Journals (Sweden)

    Rimbun Sumarsono

    2016-04-01

    Full Text Available This study is aimed to knowing Structuring the sub element of Institutional System of Beef Cattle Industry, The methods used for data collection is by distributing questionnaires, interviews with experts and literature studies. Results of questionnaires and interviews with experts used to construct a hierarchy of election strategy Beef Cattle industry development. Preparation of hierarchy elections industrial development strategy Beef Cattle using AHP technique The formulation of a model institutional system Beef Cattle industry development with key elements in the element's goal is to realize a strong institutional element is the need for government support, elements of the perpetrator is a trader. While the key elements in the benchmarks is the increasing diversification of products Beef Cattle, element of constraint is the weak institutional system, lack of government support for industrial development Beef Cattle and the lack of guidance to the Breeders. For elements of the desired changes to the industrial development Beef Cattle is the formation of an independent group of cattle at the planting site Beef Cattle

  8. Unified Approach in the DSS Development Process

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

  9. Maturity Models Development in IS Research

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann

    2015-01-01

    Maturity models are widespread in IS research and in particular, IT practitioner communities. However, theoretically sound, methodologically rigorous and empirically validated maturity models are quite rare. This literature review paper focuses on the challenges faced during the development...... literature reveals that researchers have primarily focused on developing new maturity models pertaining to domain-specific problems and/or new enterprise technologies. We find rampant re-use of the design structure of widely adopted models such as Nolan’s Stage of Growth Model, Crosby’s Grid, and Capability...... Maturity Model (CMM). Only recently have there been some research efforts to standardize maturity model development. We also identify three dominant views of maturity models and provide guidelines for various approaches of constructing maturity models with a standard vocabulary. We finally propose using...

  10. Complex systems approach to scientific publication and peer-review system: development of an agent-based model calibrated with empirical journal data.

    Science.gov (United States)

    Kovanis, Michail; Porcher, Raphaël; Ravaud, Philippe; Trinquart, Ludovic

    Scientific peer-review and publication systems incur a huge burden in terms of costs and time. Innovative alternatives have been proposed to improve the systems, but assessing their impact in experimental studies is not feasible at a systemic level. We developed an agent-based model by adopting a unified view of peer review and publication systems and calibrating it with empirical journal data in the biomedical and life sciences. We modeled researchers, research manuscripts and scientific journals as agents. Researchers were characterized by their scientific level and resources, manuscripts by their scientific value, and journals by their reputation and acceptance or rejection thresholds. These state variables were used in submodels for various processes such as production of articles, submissions to target journals, in-house and external peer review, and resubmissions. We collected data for a sample of biomedical and life sciences journals regarding acceptance rates, resubmission patterns and total number of published articles. We adjusted submodel parameters so that the agent-based model outputs fit these empirical data. We simulated 105 journals, 25,000 researchers and 410,000 manuscripts over 10 years. A mean of 33,600 articles were published per year; 19 % of submitted manuscripts remained unpublished. The mean acceptance rate was 21 % after external peer review and rejection rate 32 % after in-house review; 15 % publications resulted from the first submission, 47 % the second submission and 20 % the third submission. All decisions in the model were mainly driven by the scientific value, whereas journal targeting and persistence in resubmission defined whether a manuscript would be published or abandoned after one or many rejections. This agent-based model may help in better understanding the determinants of the scientific publication and peer-review systems. It may also help in assessing and identifying the most promising alternative systems of peer

  11. A Set Theoretical Approach to Maturity Models

    DEFF Research Database (Denmark)

    Lasrado, Lester; Vatrapu, Ravi; Andersen, Kim Normann

    2016-01-01

    Maturity Model research in IS has been criticized for the lack of theoretical grounding, methodological rigor, empirical validations, and ignorance of multiple and non-linear paths to maturity. To address these criticisms, this paper proposes a novel set-theoretical approach to maturity models ch...

  12. Innovation in Developing Countries - a New Approach

    Directory of Open Access Journals (Sweden)

    Dagmara Bubel

    2015-05-01

    Full Text Available Currently the enterprises’ development and competitive positions are determined by innovation. The importance of innovation in corporate management is a result of changes in corporate environment, as well as of preferences and changing needs of customers. These changes are accompanied by a new approach to innovation: they are no longer limited to developed countries, but also emerge in developing countries. Moreover, a reverse in the direction of innovations occurs, which means that developing countries are often not only the recipients of innovative products, but also creators and „exporters”. Given the current trends, the paper begins with the concept of innovation and deals with the subject of innovation in developing countries. The conclusion of the paper presents examples of innovative solutions originated from Poland. Although Poland ranks rather „tail end” in innovation rankings, but also deliver products that have a good chance to conquer the global market. By highlighting the importance of this reverse innovative trend, this article provides the conceptual grounds for further systematic research.

  13. Data Analysis A Model Comparison Approach, Second Edition

    CERN Document Server

    Judd, Charles M; Ryan, Carey S

    2008-01-01

    This completely rewritten classic text features many new examples, insights and topics including mediational, categorical, and multilevel models. Substantially reorganized, this edition provides a briefer, more streamlined examination of data analysis. Noted for its model-comparison approach and unified framework based on the general linear model, the book provides readers with a greater understanding of a variety of statistical procedures. This consistent framework, including consistent vocabulary and notation, is used throughout to develop fewer but more powerful model building techniques. T

  14. Metamodelling Approach and Software Tools for Physical Modelling and Simulation

    Directory of Open Access Journals (Sweden)

    Vitaliy Mezhuyev

    2015-02-01

    Full Text Available In computer science, metamodelling approach becomes more and more popular for the purpose of software systems development. In this paper, we discuss applicability of the metamodelling approach for development of software tools for physical modelling and simulation.To define a metamodel for physical modelling the analysis of physical models will be done. The result of such the analyses will show the invariant physical structures, we propose to use as the basic abstractions of the physical metamodel. It is a system of geometrical objects, allowing to build a spatial structure of physical models and to set a distribution of physical properties. For such geometry of distributed physical properties, the different mathematical methods can be applied. To prove the proposed metamodelling approach, we consider the developed prototypes of software tools.

  15. A database approach to information retrieval: The remarkable relationship between language models and region models

    CERN Document Server

    Hiemstra, Djoerd

    2010-01-01

    In this report, we unify two quite distinct approaches to information retrieval: region models and language models. Region models were developed for structured document retrieval. They provide a well-defined behaviour as well as a simple query language that allows application developers to rapidly develop applications. Language models are particularly useful to reason about the ranking of search results, and for developing new ranking approaches. The unified model allows application developers to define complex language modeling approaches as logical queries on a textual database. We show a remarkable one-to-one relationship between region queries and the language models they represent for a wide variety of applications: simple ad-hoc search, cross-language retrieval, video retrieval, and web search.

  16. MODULAR APPROACH WITH ROUGH DECISION MODELS

    Directory of Open Access Journals (Sweden)

    Ahmed T. Shawky

    2012-09-01

    Full Text Available Decision models which adopt rough set theory have been used effectively in many real world applications.However, rough decision models suffer the high computational complexity when dealing with datasets ofhuge size. In this research we propose a new rough decision model that allows making decisions based onmodularity mechanism. According to the proposed approach, large-size datasets can be divided intoarbitrary moderate-size datasets, then a group of rough decision models can be built as separate decisionmodules. The overall model decision is computed as the consensus decision of all decision modulesthrough some aggregation technique. This approach provides a flexible and a quick way for extractingdecision rules of large size information tables using rough decision models.

  17. Modular Approach with Rough Decision Models

    Directory of Open Access Journals (Sweden)

    Ahmed T. Shawky

    2012-10-01

    Full Text Available Decision models which adopt rough set theory have been used effectively in many real world applications.However, rough decision models suffer the high computational complexity when dealing with datasets ofhuge size. In this research we propose a new rough decision model that allows making decisions based onmodularity mechanism. According to the proposed approach, large-size datasets can be divided intoarbitrary moderate-size datasets, then a group of rough decision models can be built as separate decisionmodules. The overall model decision is computed as the consensus decision of all decision modulesthrough some aggregation technique. This approach provides a flexible and a quick way for extractingdecision rules of large size information tables using rough decision models.

  18. Modeling Alaska boreal forests with a controlled trend surface approach

    Science.gov (United States)

    Mo Zhou; Jingjing Liang

    2012-01-01

    An approach of Controlled Trend Surface was proposed to simultaneously take into consideration large-scale spatial trends and nonspatial effects. A geospatial model of the Alaska boreal forest was developed from 446 permanent sample plots, which addressed large-scale spatial trends in recruitment, diameter growth, and mortality. The model was tested on two sets of...

  19. Modelling diversity in building occupant behaviour: a novel statistical approach

    DEFF Research Database (Denmark)

    Haldi, Frédéric; Calì, Davide; Andersen, Rune Korsholm

    2016-01-01

    We propose an advanced modelling framework to predict the scope and effects of behavioural diversity regarding building occupant actions on window openings, shading devices and lighting. We develop a statistical approach based on generalised linear mixed models to account for the longitudinal nat...

  20. Modeling approach suitable for energy system

    Energy Technology Data Exchange (ETDEWEB)

    Goetschel, D. V.

    1979-01-01

    Recently increased attention has been placed on optimization problems related to the determination and analysis of operating strategies for energy systems. Presented in this paper is a nonlinear model that can be used in the formulation of certain energy-conversion systems-modeling problems. The model lends itself nicely to solution approaches based on nonlinear-programming algorithms and, in particular, to those methods falling into the class of variable metric algorithms for nonlinearly constrained optimization.

  1. Recent development of hydrodynamic modeling

    Science.gov (United States)

    Hirano, Tetsufumi

    2014-09-01

    In this talk, I give an overview of recent development in hydrodynamic modeling of high-energy nuclear collisions. First, I briefly discuss about current situation of hydrodynamic modeling by showing results from the integrated dynamical approach in which Monte-Carlo calculation of initial conditions, quark-gluon fluid dynamics and hadronic cascading are combined. In particular, I focus on rescattering effects of strange hadrons on final observables. Next I highlight three topics in recent development in hydrodynamic modeling. These include (1) medium response to jet propagation in di-jet asymmetric events, (2) causal hydrodynamic fluctuation and its application to Bjorken expansion and (3) chiral magnetic wave from anomalous hydrodynamic simulations. (1) Recent CMS data suggest the existence of QGP response to propagation of jets. To investigate this phenomenon, we solve hydrodynamic equations with source term which exhibits deposition of energy and momentum from jets. We find a large number of low momentum particles are emitted at large angle from jet axis. This gives a novel interpretation of the CMS data. (2) It has been claimed that a matter created even in p-p/p-A collisions may behave like a fluid. However, fluctuation effects would be important in such a small system. We formulate relativistic fluctuating hydrodynamics and apply it to Bjorken expansion. We found the final multiplicity fluctuates around the mean value even if initial condition is fixed. This effect is relatively important in peripheral A-A collisions and p-p/p-A collisions. (3) Anomalous transport of the quark-gluon fluid is predicted when extremely high magnetic field is applied. We investigate this possibility by solving anomalous hydrodynamic equations. We found the difference of the elliptic flow parameter between positive and negative particles appears due to the chiral magnetic wave. Finally, I provide some personal perspective of hydrodynamic modeling of high energy nuclear collisions

  2. Development of a model for the rational design of molecular imprinted polymer: Computational approach for combined molecular dynamics/quantum mechanics calculations

    Energy Technology Data Exchange (ETDEWEB)

    Dong Cunku [Department of Chemistry, Harbin Institute of Technology, Harbin 150090 (China); Li Xin, E-mail: lixin@hit.edu.cn [Department of Chemistry, Harbin Institute of Technology, Harbin 150090 (China); Guo Zechong [School of Municipal Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China); Qi Jingyao, E-mail: jyq@hit.edu.cn [School of Municipal Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China)

    2009-08-04

    A new rational approach for the preparation of molecularly imprinted polymer (MIP) based on the combination of molecular dynamics (MD) simulations and quantum mechanics (QM) calculations is described in this work. Before performing molecular modeling, a virtual library of functional monomers was created containing forty frequently used monomers. The MD simulations were first conducted to screen the top three monomers from virtual library in each porogen-acetonitrile, chloroform and carbon tetrachloride. QM simulations were then performed with an aim to select the optimum monomer and progen solvent in which the QM simulations were carried out; the monomers giving the highest binding energies were chosen as the candidate to prepare MIP in its corresponding solvent. The acetochlor, a widely used herbicide, was chosen as the target analyte. According to the theoretical calculation results, the MIP with acetochlor as template was prepared by emulsion polymerization method using N,N-methylene bisacrylamide (MBAAM) as functional monomer and divinylbenzene (DVB) as cross-linker in chloroform. The synthesized MIP was then tested by equilibrium-adsorption method, and the MIP demonstrated high removal efficiency to the acetochlor. Mulliken charge distribution and {sup 1}H NMR spectroscopy of the synthesized MIP provided insight on the nature of recognition during the imprinting process probing the governing interactions for selective binding site formation at a molecular level. We think the computer simulation method first proposed in this paper is a novel and reliable method for the design and synthesis of MIP.

  3. MATLAB/Simulink Based Study of Different Approaches Using Mathematical Model of Differential Equations

    National Research Council Canada - National Science Library

    Vijay Nehra

    2014-01-01

    .... The present paper addresses different approaches used to derive mathematical models of first and second order system, developing MATLAB script implementation and building a corresponding Simulink model...

  4. Developing a complex approach to health phenomena (step 1)

    Science.gov (United States)

    Cifuentes, Myriam Patricia

    Health is a complex object for science and operative levels, partly because there are many approaches defining it but not scientifically sufficient or operatively accepted. This is relevant for health understanding but also for decision making on health related problems. "Determinants of Health" as a widely accepted theoretical proposal, identifies as problematic the reductionist view of health as the disease opposite, attempting to develop it positively according to WHO's definition, proposing a set of factors determining health outcomes. Though this allows a larger comprehension of health causes and effects, still has insufficiently defined theoretical statements and unproved assumptions which difficult understanding and effective actions orientation. Complexity deductive modeling since the insufficiently formalized frameworks, implies incorporating unmanageable object assumptions or reducing health broadness. Taking profit of Bogotá government adherence to DH proposal leading a health information system development, was possible inductive modeling since a systemic massive database (690.000 registries). In this way, DH theoretical statements about health components connectedness were explored by classic statistic approach, and by learning Bayesian networks from data (data mining). First approach showed understanding difficulties. Second was advantageous in approximating within and between determinants relationship structure. However, though DH introduces a systemic approach in considering diverse interacting elements is not empirically satisfactory to exhibit all the meaning of health complexity, because just matches analytic fashioned constructs depending on data expression. A strong networked model developing health complexity, needs the orientation by theoretical constructs as human agency and organization, to explore and understand emergent patterns of health.

  5. Territorial development. A new approach to development processes for the economies of the developing countries

    Directory of Open Access Journals (Sweden)

    Bernard Pecqueur

    2013-12-01

    Full Text Available This article seeks to show how the elements of a (flexible and adaptable model of territorial development, whose roots are anchored in the analysis of coordination among pre-capitalist actors, can take on a more concrete form in developing economies. Our hypothesis is that the application of this model functions as a resurgence of pre-capitalist production relations, revalidated by local practices and renewed by territorial dynamics. Is such a return to pre-capitalist ways possible and realistic despite the obstacles and, if so, under what conditions? These are the questions this paper seeks to address, by the way of a specifically economic analysis focused on the dynamics of productive systems. On the first part, we review the fundamental principles of a model of territorial development based on a local system of actors, which assumes that the territory is “constructed” and is founded, according to our approach, on the principle of specification. On the second part, we assess the feasibility of this model in developing economies, remembering that we are starting from practices that are already old; practices involving risks and that assume certain conditions of implementation.

  6. Continuous Molecular Fields Approach Applied to Structure-Activity Modeling

    CERN Document Server

    Baskin, Igor I

    2013-01-01

    The Method of Continuous Molecular Fields is a universal approach to predict various properties of chemical compounds, in which molecules are represented by means of continuous fields (such as electrostatic, steric, electron density functions, etc). The essence of the proposed approach consists in performing statistical analysis of functional molecular data by means of joint application of kernel machine learning methods and special kernels which compare molecules by computing overlap integrals of their molecular fields. This approach is an alternative to traditional methods of building 3D structure-activity and structure-property models based on the use of fixed sets of molecular descriptors. The methodology of the approach is described in this chapter, followed by its application to building regression 3D-QSAR models and conducting virtual screening based on one-class classification models. The main directions of the further development of this approach are outlined at the end of the chapter.

  7. Building Water Models, A Different Approach

    CERN Document Server

    Izadi, Saeed; Onufriev, Alexey V

    2014-01-01

    Simplified, classical models of water are an integral part of atomistic molecular simulations, especially in biology and chemistry where hydration effects are critical. Yet, despite several decades of effort, these models are still far from perfect. Presented here is an alternative approach to constructing point charge water models - currently, the most commonly used type. In contrast to the conventional approach, we do not impose any geometry constraints on the model other than symmetry. Instead, we optimize the distribution of point charges to best describe the "electrostatics" of the water molecule, which is key to many unusual properties of liquid water. The search for the optimal charge distribution is performed in 2D parameter space of key lowest multipole moments of the model, to find best fit to a small set of bulk water properties at room temperature. A virtually exhaustive search is enabled via analytical equations that relate the charge distribution to the multipole moments. The resulting "optimal"...

  8. TMT approach to observatory software development process

    Science.gov (United States)

    Buur, Hanne; Subramaniam, Annapurni; Gillies, Kim; Dumas, Christophe; Bhatia, Ravinder

    2016-07-01

    The purpose of the Observatory Software System (OSW) is to integrate all software and hardware components of the Thirty Meter Telescope (TMT) to enable observations and data capture; thus it is a complex software system that is defined by four principal software subsystems: Common Software (CSW), Executive Software (ESW), Data Management System (DMS) and Science Operations Support System (SOSS), all of which have interdependencies with the observatory control systems and data acquisition systems. Therefore, the software development process and plan must consider dependencies to other subsystems, manage architecture, interfaces and design, manage software scope and complexity, and standardize and optimize use of resources and tools. Additionally, the TMT Observatory Software will largely be developed in India through TMT's workshare relationship with the India TMT Coordination Centre (ITCC) and use of Indian software industry vendors, which adds complexity and challenges to the software development process, communication and coordination of activities and priorities as well as measuring performance and managing quality and risk. The software project management challenge for the TMT OSW is thus a multi-faceted technical, managerial, communications and interpersonal relations challenge. The approach TMT is using to manage this multifaceted challenge is a combination of establishing an effective geographically distributed software team (Integrated Product Team) with strong project management and technical leadership provided by the TMT Project Office (PO) and the ITCC partner to manage plans, process, performance, risk and quality, and to facilitate effective communications; establishing an effective cross-functional software management team composed of stakeholders, OSW leadership and ITCC leadership to manage dependencies and software release plans, technical complexities and change to approved interfaces, architecture, design and tool set, and to facilitate

  9. Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

    Directory of Open Access Journals (Sweden)

    Luettich Karsta

    2014-06-01

    Full Text Available The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening model in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops lung tumors spontaneously. Moreover, there is a considerable gap in our understanding of the underlying mechanisms of pulmonary chemical carcinogenesis in the A/J mouse. Therefore, we examined the differences between spontaneous and cigarette smokerelated lung tumors in the A/J mouse model using mRNA and microRNA (miRNA profiling. Male A/J mice were exposed whole-body to mainstream cigarette smoke (MS for 18 months. Gene expression interaction term analysis of lung tumors and surrounding nontumorous parenchyma samples from animals that were exposed to either 300 mg/m3 MS or sham-exposed to fresh air indicated significant differential expression of 296 genes. Ingenuity Pathway Analysis® (IPA® indicated an overall suppression of the humoral immune response, which was accompanied by a disruption of sphingolipid and glycosaminoglycan metabolism and a deregulation of potentially oncogenic miRNA in tumors of MS-exposed A/J mice. Thus, we propose that MS exposure leads to severe perturbations in pathways essential for tumor recognition by the immune system, thereby potentiating the ability of tumor cells to escape from immune surveillance. Further, exposure to MS appeared to affect expression of miRNA, which have previously been implicated in carcinogenesis and are thought to contribute to tumor progression. Finally, we identified a 50-gene expression signature and show its utility in distinguishing between cigarette smoke-related and spontaneous lung tumors

  10. Environmental Radiation Effects on Mammals A Dynamical Modeling Approach

    CERN Document Server

    Smirnova, Olga A

    2010-01-01

    This text is devoted to the theoretical studies of radiation effects on mammals. It uses the framework of developed deterministic mathematical models to investigate the effects of both acute and chronic irradiation in a wide range of doses and dose rates on vital body systems including hematopoiesis, small intestine and humoral immunity, as well as on the development of autoimmune diseases. Thus, these models can contribute to the development of the system and quantitative approaches in radiation biology and ecology. This text is also of practical use. Its modeling studies of the dynamics of granulocytopoiesis and thrombocytopoiesis in humans testify to the efficiency of employment of the developed models in the investigation and prediction of radiation effects on these hematopoietic lines. These models, as well as the properly identified models of other vital body systems, could provide a better understanding of the radiation risks to health. The modeling predictions will enable the implementation of more ef...

  11. Towards a CPN-Based Modelling Approach for Reconciling Verification and Implementation of Protocol Models

    DEFF Research Database (Denmark)

    Simonsen, Kent Inge; Kristensen, Lars Michael

    2013-01-01

    and implementation. Our approach has been developed in the context of the Coloured Petri Nets (CPNs) modelling language. We illustrate our approach by presenting a descriptive specification model of the Websocket protocol which is currently under development by the Internet Engineering Task Force (IETF), and we show......Formal modelling of protocols is often aimed at one specific purpose such as verification or automatically generating an implementation. This leads to models that are useful for one purpose, but not for others. Being able to derive models for verification and implementation from a single model...

  12. Curriculum Development: A Philosophical Model.

    Science.gov (United States)

    Bruening, William H.

    Presenting models based on the philosophies of Carl Rogers, John Dewey, Erich Fromm, and Jean-Paul Sartre, this paper proposes a philosophical approach to education and concludes with pragmatic suggestions concerning teaching based on a fully-functioning-person model. The fully-functioning person is characterized as being open to experience,…

  13. Sustainable intensification: a multifaceted, systemic approach to international development.

    Science.gov (United States)

    Himmelstein, Jennifer; Ares, Adrian; van Houweling, Emily

    2016-12-01

    Sustainable intensification (SI) is a term increasingly used to describe a type of approach applied to international agricultural projects. Despite its widespread use, there is still little understanding or knowledge of the various facets of this composite paradigm. A review of the literature has led to the formalization of three principles that convey the current characterization of SI, comprising a whole system, participatory, agroecological approach. Specific examples of potential bottlenecks to the SI approach are cited, in addition to various technologies and techniques that can be applied to overcome these obstacles. Models of similar, succcessful approaches to agricultural development are examined, along with higher level processes. Additionally, this review explores the desired end points of SI and argues for the inclusion of gender and nutrition throughout the process. To properly apply the SI approach, its various aspects need to be understood and adapted to different cultural and geographic situations. New modeling systems and examples of the effective execution of SI strategies can assist with the successful application of the SI paradigm within complex developing communities. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  14. Strategic approach to the science and innovation development: Chinese example

    Directory of Open Access Journals (Sweden)

    Дмитро Петрович Єфремов

    2015-09-01

    Full Text Available China has accumulated exclusive experience in the state support of science and innovation. The results of its study are reported in this article. The analysis of specific program-planning approach for science and technology development made it possible to reveal the role of innovation in the national model of acceleration of China's economy. The positive and negative characteristics of the Chinese approach based on public sector to incentives in science and technology and knowledge transfer from science to production are highlighted

  15. A Domain Knowledge Driven Approach for User Interface Software Development

    Institute of Scientific and Technical Information of China (English)

    王海鹰; 刘慎权

    1991-01-01

    A domain knowledge driven user interface development approach is described.As a conceptual design of the user interface,the domain knowledge defines the user interface in terms of objects,actions and their relationships that the user would use to interact with the application system.It also serves as input to a user interface management system (UIMS) and is the kernel of the target user interface.The principal ideas and the implementation techniques of the approach is discussed.The user interface model,user interface designer oriented high-level specification notatiopn,and the transformation algorithms on domain knowledge are presented.

  16. Comparison of approaches for parameter estimation on stochastic models: Generic least squares versus specialized approaches.

    Science.gov (United States)

    Zimmer, Christoph; Sahle, Sven

    2016-04-01

    Parameter estimation for models with intrinsic stochasticity poses specific challenges that do not exist for deterministic models. Therefore, specialized numerical methods for parameter estimation in stochastic models have been developed. Here, we study whether dedicated algorithms for stochastic models are indeed superior to the naive approach of applying the readily available least squares algorithm designed for deterministic models. We compare the performance of the recently developed multiple shooting for stochastic systems (MSS) method designed for parameter estimation in stochastic models, a stochastic differential equations based Bayesian approach and a chemical master equation based techniques with the least squares approach for parameter estimation in models of ordinary differential equations (ODE). As test data, 1000 realizations of the stochastic models are simulated. For each realization an estimation is performed with each method, resulting in 1000 estimates for each approach. These are compared with respect to their deviation to the true parameter and, for the genetic toggle switch, also their ability to reproduce the symmetry of the switching behavior. Results are shown for different set of parameter values of a genetic toggle switch leading to symmetric and asymmetric switching behavior as well as an immigration-death and a susceptible-infected-recovered model. This comparison shows that it is important to choose a parameter estimation technique that can treat intrinsic stochasticity and that the specific choice of this algorithm shows only minor performance differences.

  17. Testing Strategies for Model-Based Development

    Science.gov (United States)

    Heimdahl, Mats P. E.; Whalen, Mike; Rajan, Ajitha; Miller, Steven P.

    2006-01-01

    This report presents an approach for testing artifacts generated in a model-based development process. This approach divides the traditional testing process into two parts: requirements-based testing (validation testing) which determines whether the model implements the high-level requirements and model-based testing (conformance testing) which determines whether the code generated from a model is behaviorally equivalent to the model. The goals of the two processes differ significantly and this report explores suitable testing metrics and automation strategies for each. To support requirements-based testing, we define novel objective requirements coverage metrics similar to existing specification and code coverage metrics. For model-based testing, we briefly describe automation strategies and examine the fault-finding capability of different structural coverage metrics using tests automatically generated from the model.

  18. Alpine Windharvest: development of information base regarding potentials and the necessary technical, legal and socio-economic conditions for expanding wind energy in the Alpine Space - Alpine Space wind map - Modeling approach

    Energy Technology Data Exchange (ETDEWEB)

    Schaffner, B.; Remund, J. [Meteotest, Berne (Switzerland)

    2005-07-01

    This report presents describes the development work carried out by the Swiss meteorology specialists of the company METEOTEST as part of a project carried out together with the Swiss wind-energy organisation 'Suisse Eole'. The framework for the project is the EU Interreg IIIB Alpine Space Programme, a European Community Initiative Programme funded by the European Regional Development Fund. The project investigated the use of digital relief-analysis. The series of reports describes the development and use of a basic information system to aid the investigation of the technical, legal and socio-economical conditions for the use of wind energy in the alpine area. This report discusses two modelling approaches investigated for use in the definition of a wind map for the alpine area. The method chosen and its application are discussed. The various sources of information for input to the model are listed and discussed.

  19. An evolutionary morphological approach for software development cost estimation.

    Science.gov (United States)

    Araújo, Ricardo de A; Oliveira, Adriano L I; Soares, Sergio; Meira, Silvio

    2012-08-01

    In this work we present an evolutionary morphological approach to solve the software development cost estimation (SDCE) problem. The proposed approach consists of a hybrid artificial neuron based on framework of mathematical morphology (MM) with algebraic foundations in the complete lattice theory (CLT), referred to as dilation-erosion perceptron (DEP). Also, we present an evolutionary learning process, called DEP(MGA), using a modified genetic algorithm (MGA) to design the DEP model, because a drawback arises from the gradient estimation of morphological operators in the classical learning process of the DEP, since they are not differentiable in the usual way. Furthermore, an experimental analysis is conducted with the proposed model using five complex SDCE problems and three well-known performance metrics, demonstrating good performance of the DEP model to solve SDCE problems.

  20. Educational Game Development Models

    Directory of Open Access Journals (Sweden)

    Mehmet Emin Korkusuz

    2013-12-01

    Full Text Available Recent research on the subject shows that students spend more time on computer games than other activities such as reading book or watching TV. It is possible that this time-consuming activity can become much more effective by educator-game sector cooperation. Which type of game students prefer mostly; how the educational content can be articulated the games without diminishing the playability and enjoyableness of it; and the impact of the competition in the games on process and students are just several titles examined in the studies. This scope presents the types of computer game, qualities of educational games, and educational games designs which are recommended for developing educational games. It also presents a set of knowledge about the importance of educational games in mathematics and physic education, and some studies on this field. In the scope, some strategies, about educational game development process, are recommended educators and software developers in the sector who intend to develop educational games based on the literature.

  1. Development Model for Research Infrastructures

    Science.gov (United States)

    Wächter, Joachim; Hammitzsch, Martin; Kerschke, Dorit; Lauterjung, Jörn

    2015-04-01

    . The maturity of individual scientific domains differs considerably. • Technologically and organisationally many different RI components have to be integrated. Individual systems are often complex and have a long-term history. Existing approaches are on different maturity levels, e.g. in relation to the standardisation of interfaces. • The concrete implementation process consists of independent and often parallel development activities. In many cases no detailed architectural blue-print for the envisioned system exists. • Most of the funding currently available for RI implementation is provided on a project basis. To increase the synergies in infrastructure development the authors propose a specific RI Maturity Model (RIMM) that is specifically qualified for open system-of-system environments. RIMM is based on the concepts of Capability Maturity Models for organisational development, concretely the Levels of Conceptual Interoperability Model (LCIM) specifying the technical, syntactical, semantic, pragmatic, dynamic, and conceptual layers of interoperation [1]. The model is complemented by the identification and integration of growth factors (according to the Nolan Stages Theory [2]). These factors include supply and demand factors. Supply factors comprise available resources, e.g., data, services and IT-management capabilities including organisations and IT-personal. Demand factors are the overall application portfolio for RIs but also the skills and requirements of scientists and communities using the infrastructure. RIMM thus enables a balanced development process of RI and RI components by evaluating the status of the supply and demand factors in relation to specific levels of interoperability. [1] Tolk, A., Diallo, A., Turnitsa, C. (2007): Applying the Levels of Conceptual Interoperability Model in Support of Integratability, Interoperability, and Composability for System-of-Systems Engineering. Systemics, Cybernetics and Informatics, Volume 5 - Number 5. [2

  2. Suitability of Modern Software Development Methodologies for Model Driven Development

    Directory of Open Access Journals (Sweden)

    Ruben Picek

    2009-12-01

    Full Text Available As an answer to today’s growing challenges in software industry, wide spectrum of new approaches of software development has occurred. One prominent direction is currently most promising software development paradigm called Model Driven Development (MDD. Despite a lot of skepticism and problems, MDD paradigm is being used and improved to accomplish many inherent potential benefits. In the methodological approach of software development it is necessary to use some kind of development process. Modern methodologies can be classified into two main categories: formal or heavyweight and agile or lightweight. But when it is a question about MDD and development process for MDD, currently known methodologies are very poor or better said they don't have any explanation of MDD process. As the result of research, in this paper, author examines the possibilities of using existing modern software methodologies in context of MDD paradigm.

  3. Models for Sustainable Regional Development

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    2008-01-01

    The chapter presents a model for integrated cross-cultural knowledge building and entrepreneurship. In addtion, narrative and numeric simulations methods are suggested to promote a further development and implementation of the model in China.......The chapter presents a model for integrated cross-cultural knowledge building and entrepreneurship. In addtion, narrative and numeric simulations methods are suggested to promote a further development and implementation of the model in China....

  4. Models for Sustainable Regional Development

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    2008-01-01

    The chapter presents a model for integrated cross-cultural knowledge building and entrepreneurship. In addtion, narrative and numeric simulations methods are suggested to promote a further development and implementation of the model in China.......The chapter presents a model for integrated cross-cultural knowledge building and entrepreneurship. In addtion, narrative and numeric simulations methods are suggested to promote a further development and implementation of the model in China....

  5. Development of a dynamic energy budget modeling approach to investigate the effects of temperature and resource limitation on mercury bioaccumulation in Fundulus heteroclitus-presentation

    Science.gov (United States)

    Dynamic energy budget (DEB) theory provides a generalizable and broadly applicable framework to connect sublethal toxic effects on individuals to changes in population survival and growth. To explore this approach, we are conducting growth and bioaccumulation studies that contrib...

  6. A novel approach to modeling and diagnosing the cardiovascular system

    Energy Technology Data Exchange (ETDEWEB)

    Keller, P.E.; Kangas, L.J.; Hashem, S.; Kouzes, R.T. [Pacific Northwest Lab., Richland, WA (United States); Allen, P.A. [Life Link, Richland, WA (United States)

    1995-07-01

    A novel approach to modeling and diagnosing the cardiovascular system is introduced. A model exhibits a subset of the dynamics of the cardiovascular behavior of an individual by using a recurrent artificial neural network. Potentially, a model will be incorporated into a cardiovascular diagnostic system. This approach is unique in that each cardiovascular model is developed from physiological measurements of an individual. Any differences between the modeled variables and the variables of an individual at a given time are used for diagnosis. This approach also exploits sensor fusion to optimize the utilization of biomedical sensors. The advantage of sensor fusion has been demonstrated in applications including control and diagnostics of mechanical and chemical processes.

  7. Post-16 Biology--Some Model Approaches?

    Science.gov (United States)

    Lock, Roger

    1997-01-01

    Outlines alternative approaches to the teaching of difficult concepts in A-level biology which may help student learning by making abstract ideas more concrete and accessible. Examples include models, posters, and poems for illustrating meiosis, mitosis, genetic mutations, and protein synthesis. (DDR)

  8. The Role of Relational Reward Benefits for Developing the Non-Financial Value of a Customer to an Organization: Structural Equation Modeling Approach

    Directory of Open Access Journals (Sweden)

    Enny Kristiani

    2014-10-01

    Full Text Available Research on the customer value to an organization has been widely explored, yet most studies only determined on the financial value based on the customer’s purchasing behavior. The value of customers beyond their purchasing behavior –defined as the relational worth - has not been commonly captured yet. This non-financial value is one of the drivers in retaining customers, hence it becomes a crucial factor in preserving the profitability of the organization. For this reason, this paper aims to examine the customer non-financial valuations of a loyalty reward program. The scope of the study covered a reward program involving consumer exertions in the context of a Frequent Flyer Program (FFP offered by an airline in Indonesia. The hypotheses are empirically tested with a sample of FFP members conducted through an online survey (n=475. The data were statistically analyzed using structural equation modeling (SEM as a first order construct. Results indicate that the perceived social rewards lead to an affective and normative commitment as well as consumers’ satisfaction, while the economic reward did not have an effect on developing affective bonds with members for long-term relationships. The relational benefit offered through the FFP creates affectively and normatively committed members who produce relational behaviors, in terms of WOM, immunity, openness and acquiescence of the members to the airline. Furthermore, the FFP members produced social behaviors toward the airline when they felt satisfied with their relational exchanges.

  9. Development of Enterprise Architecture using a Framework with Agile Approach

    Directory of Open Access Journals (Sweden)

    Fanny Sandoval

    2017-02-01

    Full Text Available The development of an enterprise architecture (EA in large organizations is complex. Thus, is important that the implementation of EA creates value in early stages of the process. This document contains a proposal of an EA framework design with agile approach based in TOGAF. This proposal is done with the objective to streamline the EA process. This framework presents a new design taking into account the current regulations, the target line of the organization and the principles proposed by the agile approach of EA. The objectives of each phase of the architecture development method ADM of TOGAF are matched with the requirements of the organization to extract only those that are aligned to the business. The deliverables proposed by TOGAF are analyzed with the goal to obtain, integrate and reduce the documentation in the implementation and modeling phases. This reduction allows more flexibility, less impact in the processes, reduction in development time and costs.

  10. A study of multidimensional modeling approaches for data warehouse

    Science.gov (United States)

    Yusof, Sharmila Mat; Sidi, Fatimah; Ibrahim, Hamidah; Affendey, Lilly Suriani

    2016-08-01

    Data warehouse system is used to support the process of organizational decision making. Hence, the system must extract and integrate information from heterogeneous data sources in order to uncover relevant knowledge suitable for decision making process. However, the development of data warehouse is a difficult and complex process especially in its conceptual design (multidimensional modeling). Thus, there have been various approaches proposed to overcome the difficulty. This study surveys and compares the approaches of multidimensional modeling and highlights the issues, trend and solution proposed to date. The contribution is on the state of the art of the multidimensional modeling design.

  11. Developing therapeutic approaches for metachromatic leukodystrophy

    Directory of Open Access Journals (Sweden)

    Patil SA

    2013-08-01

    Full Text Available Shilpa A Patil,1 Gustavo HB Maegawa1,2 1McKusick-Nathans Institute of Genetic Medicine, 2Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, MD, USA Abstract: Metachromatic leukodystrophy (MLD is an autosomal recessive lysosomal disorder caused by the deficiency of arylsulfatase A (ASA, resulting in impaired degradation of sulfatide, an essential sphingolipid of myelin. The clinical manifestations of MLD are characterized by progressive demyelination and subsequent neurological symptoms resulting in severe debilitation. The availability of therapeutic options for treating MLD is limited but expanding with a number of early stage clinical trials already in progress. In the development of therapeutic approaches for MLD, scientists have been facing a number of challenges including blood–brain barrier (BBB penetration, safety issues concerning therapies targeting the central nervous system, uncertainty regarding the ideal timing for intervention in the disease course, and the lack of more in-depth understanding of the molecular pathogenesis of MLD. Here, we discuss the current status of the different approaches to developing therapies for MLD. Hematopoietic stem cell transplantation has been used to treat MLD patients, utilizing both umbilical cord blood and bone marrow sources. Intrathecal enzyme replacement therapy and gene therapies, administered locally into the brain or by generating genetically modified hematopoietic stem cells, are emerging as novel strategies. In pre-clinical studies, different cell delivery systems including microencapsulated cells or selectively neural cells have shown encouraging results. Small molecules that are more likely to cross the BBB can be used as enzyme enhancers of diverse ASA mutants, either as pharmacological chaperones, or proteostasis regulators. Specific small molecules may also be used to reduce the biosynthesis of sulfatides, or target different affected downstream pathways

  12. Genetic Approaches to Develop Salt Tolerant Germplasm

    KAUST Repository

    Tester, Mark A.

    2015-08-19

    Forty percent of the world\\'s food is produced under irrigation, and this is directly threatened by over-exploitation and changes in the global environment. One way to address this threat is to develop systems for increasing our ability to use lower quality water, in particular saline water. Low cost partial desalination of brackish water, use of saline water for cooling and increases in the salinity tolerance of crops can all contribute to the development of this new agricultural system. In this talk, the focus will be on the use of forward genetic approaches for discovery of genes related to salinity tolerance in barley and tomatoes. Rather than studying salinity tolerance as a trait in itself, we dissect salinity tolerance into a series of components that are hypothesised to contribute to overall salinity tolerance (following the paradigm of Munns & Tester, 2008). For example, one significant component of tolerance of most crop plants to moderate soil salinity is due to the ability to maintain low concentrations of Na+ in the leaves, and much analysis of this aspect has been done (e.g. Roy et al., 2013, 2014). A major site for the control of shoot Na+ accumulation is at the plasma membrane of the mature stele of the root. Alleles of HKT, a major gene underlying this transport process have been characterized and, in work led by Dr Rana Munns (CSIRO), have now been introgressed into commercial durum wheat and led to significantly increased yields in saline field conditions (Munns et al., 2012). The genotyping of mapping populations is now highly efficient. However, the ability to quantitatively phenotype these populations is now commonly limiting forward progress in plant science. The increasing power of digital imaging and computational technologies offers the opportunity to relieve this phenotyping bottleneck. The Plant Accelerator is a 4500m2 growth facility that provides non-destructive phenotyping of large populations of plants (http

  13. Asteroid modeling for testing spacecraft approach and landing.

    Science.gov (United States)

    Martin, Iain; Parkes, Steve; Dunstan, Martin; Rowell, Nick

    2014-01-01

    Spacecraft exploration of asteroids presents autonomous-navigation challenges that can be aided by virtual models to test and develop guidance and hazard-avoidance systems. Researchers have extended and applied graphics techniques to create high-resolution asteroid models to simulate cameras and other spacecraft sensors approaching and descending toward asteroids. A scalable model structure with evenly spaced vertices simplifies terrain modeling, avoids distortion at the poles, and enables triangle-strip definition for efficient rendering. To create the base asteroid models, this approach uses two-phase Poisson faulting and Perlin noise. It creates realistic asteroid surfaces by adding both crater models adapted from lunar terrain simulation and multiresolution boulders. The researchers evaluated the virtual asteroids by comparing them with real asteroid images, examining the slope distributions, and applying a surface-relative feature-tracking algorithm to the models.

  14. PUMA Development through a Multi physics Approach

    Energy Technology Data Exchange (ETDEWEB)

    Cheon, Jinsik; Kim, Junehyung; Lee, Byoungoon; Lee, Chanbock [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    Meanwhile advances of numerical methods make it possible for the multi physics problem to be solved in a fully coupled way. In addition to a multidimensional, multi physical approach, a nuclear fuel performance analysis code, which is 1D code, should be improved by accommodating the state-of-the-art in the numerical analysis to support current fuel design and performance analysis. In particular, the coupling between the mechanical equilibrium equation and a set of numerically stiff kinetics equations for fission gas release is of great importance for a multi physics simulation of nuclear fuel. Instead, coupling between temperature and fuel constituent was found to be made with a relative ease by employing an ordinary differential equations solver. As an effort for a new SFR metal fuel performance analysis code, called PUMA (Performance of Uranium Metal fuel rod Analysis code), the deformation of U-Zr fuel for SFR in connection with a fission gas release model is analyzed. A finite element analyses for purely mechanical problems are performed using a backward differentiation formula, and are subjected to scrupulous verification with Abaqus. Then mechanical equilibrium equation and the equations for fission gas release are coupled with the same differential-algebraic equations (DAE) solver.

  15. Vaccinomics Approach to Tick Vaccine Development.

    Science.gov (United States)

    Contreras, Marinela; Villar, Margarita; Alberdi, Pilar; de la Fuente, José

    2016-01-01

    Ticks are blood-feeding arthropod ectoparasites that transmit disease-causing pathogens to humans and animals worldwide. Vaccines using tick antigens have proven to be cost-effective and environmental friendly for the control of vector infestations and pathogen infection and transmission. However, new strategies are needed to identify tick protective antigens for development of improved vaccines. These strategies will be greatly enhanced by vaccinomics approaches starting from the study of tick-host-pathogen molecular interactions and ending in the characterization and validation of vaccine formulations. The discovery of tick antigens that affect both tick infestations and pathogen infection/transmission could be used for vaccines targeting human and animal populations at risk and reservoir species to reduce host exposure to ticks while reducing the number of infected ticks and their vector capacity for pathogens that affect human and animal health. In this chapter, we describe methods of the vaccinomics platform using transcriptomics and proteomics for the identification of candidate protective antigens in Ixodes scapularis, the vector for human and animal granulocytic anaplasmosis, tick-borne encephalitis, and Lyme disease.

  16. MODEL DRIVEN DEVELOPMENT OF ONLINE BANKING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Bresfelean Vasile Paul

    2011-07-01

    Full Text Available In case of online applications the cycle of software development varies from the routine. The online environment, the variety of users, the treatability of the mass of information created by them, the reusability and the accessibility from different devices are all factors of these systems complexity. The use of model drive approach brings several advantages that ease up the development process. Working prototypes that simplify client relationship and serve as the base of model tests can be easily made from models describing the system. These systems make possible for the banks clients to make their desired actions from anywhere. The user has the possibility of accessing information or making transactions.

  17. DEVELOPMENT OF THE STRUCTURAL MATRIX APPROACH IN ORGANIZATIONAL DIAGNOSTICS

    Directory of Open Access Journals (Sweden)

    Mishlanova Marina Yur'evna

    2012-07-01

    The proposed approach discloses private constituents of elements, communications, organizational layers, generalized characteristics of layers, and partial effects. This approach may be used to simulate a system of forces, items of pressure, and organizational problems. The most advanced state of stability and sustainable development is now provided with the structure within which the elements remain in certain natural interdependence (symmetry, or balance. Formation of this model is based on thorough diagnostics of an organization through the employment of the structural matrix approach and the audit of the following characteristics: labour efficiency, reliability and flexibility of communications, uniformity of distribution of communications and their coordination, connectivity of elements and layers with account for their impact, degree of freedom of elements, layers and the system as a whole, reliability, rigidity, adaptability, stability of the organizational structure.

  18. A Bayesian Shrinkage Approach for AMMI Models.

    Science.gov (United States)

    da Silva, Carlos Pereira; de Oliveira, Luciano Antonio; Nuvunga, Joel Jorge; Pamplona, Andrezza Kéllen Alves; Balestre, Marcio

    2015-01-01

    Linear-bilinear models, especially the additive main effects and multiplicative interaction (AMMI) model, are widely applicable to genotype-by-environment interaction (GEI) studies in plant breeding programs. These models allow a parsimonious modeling of GE interactions, retaining a small number of principal components in the analysis. However, one aspect of the AMMI model that is still debated is the selection criteria for determining the number of multiplicative terms required to describe the GE interaction pattern. Shrinkage estimators have been proposed as selection criteria for the GE interaction components. In this study, a Bayesian approach was combined with the AMMI model with shrinkage estimators for the principal components. A total of 55 maize genotypes were evaluated in nine different environments using a complete blocks design with three replicates. The results show that the traditional Bayesian AMMI model produces low shrinkage of singular values but avoids the usual pitfalls in determining the credible intervals in the biplot. On the other hand, Bayesian shrinkage AMMI models have difficulty with the credible interval for model parameters, but produce stronger shrinkage of the principal components, converging to GE matrices that have more shrinkage than those obtained using mixed models. This characteristic allowed more parsimonious models to be chosen, and resulted in models being selected that were similar to those obtained by the Cornelius F-test (α = 0.05) in traditional AMMI models and cross validation based on leave-one-out. This characteristic allowed more parsimonious models to be chosen and more GEI pattern retained on the first two components. The resulting model chosen by posterior distribution of singular value was also similar to those produced by the cross-validation approach in traditional AMMI models. Our method enables the estimation of credible interval for AMMI biplot plus the choice of AMMI model based on direct posterior

  19. A Bayesian Shrinkage Approach for AMMI Models.

    Directory of Open Access Journals (Sweden)

    Carlos Pereira da Silva

    Full Text Available Linear-bilinear models, especially the additive main effects and multiplicative interaction (AMMI model, are widely applicable to genotype-by-environment interaction (GEI studies in plant breeding programs. These models allow a parsimonious modeling of GE interactions, retaining a small number of principal components in the analysis. However, one aspect of the AMMI model that is still debated is the selection criteria for determining the number of multiplicative terms required to describe the GE interaction pattern. Shrinkage estimators have been proposed as selection criteria for the GE interaction components. In this study, a Bayesian approach was combined with the AMMI model with shrinkage estimators for the principal components. A total of 55 maize genotypes were evaluated in nine different environments using a complete blocks design with three replicates. The results show that the traditional Bayesian AMMI model produces low shrinkage of singular values but avoids the usual pitfalls in determining the credible intervals in the biplot. On the other hand, Bayesian shrinkage AMMI models have difficulty with the credible interval for model parameters, but produce stronger shrinkage of the principal components, converging to GE matrices that have more shrinkage than those obtained using mixed models. This characteristic allowed more parsimonious models to be chosen, and resulted in models being selected that were similar to those obtained by the Cornelius F-test (α = 0.05 in traditional AMMI models and cross validation based on leave-one-out. This characteristic allowed more parsimonious models to be chosen and more GEI pattern retained on the first two components. The resulting model chosen by posterior distribution of singular value was also similar to those produced by the cross-validation approach in traditional AMMI models. Our method enables the estimation of credible interval for AMMI biplot plus the choice of AMMI model based on direct

  20. Reconciliation with oneself and with others: From approach to model

    Directory of Open Access Journals (Sweden)

    Nikolić-Ristanović Vesna

    2010-01-01

    Full Text Available The paper intends to present the approach to dealing with war and its consequences which was developed within Victimology Society of Serbia over the last five years, in the framework of Association Joint Action for Truth and Reconciliation (ZAIP. First, the short review of the Association and the process through which ZAIP approach to dealing with a past was developed is presented. Then, the detailed description of the approach itself, with identification of its most important specificities, is presented. In the conclusion, next steps, aimed at development of the model of reconciliation which will have the basis in ZAIP approach and which will be appropriate to social context of Serbia and its surrounding, are suggested.

  1. Scientific and methodical approaches to analysis of enterprise development potential

    Directory of Open Access Journals (Sweden)

    Hrechina Iryna V.

    2014-01-01

    Full Text Available The modern state of the Ukrainian economy urge enterprises to search for new possibilities of their development, which makes the study subject topical. The article systemises existing approaches to analysis of the potential of enterprise development and marks out two main scientific approaches: first is directed at analysis of prospects of self-development of the economic system; the second – at analysis of probability of possibilities of growth. In order to increase the quality of the process of formation of methods of analysis of potential of enterprise development, the article offers an organisation model of methods and characterises its main elements. It develops methods of analysis, in the basis of which there are indicators of potentialogical sustainability. Scientific novelty of the obtained results lies in a possibility of identification of main directions of enterprise development with the use of the enterprise development potential ration: self-development or probability of augmenting opportunities, which is traced through interconnection of resources and profit.

  2. A MOOC approach for training researchers in developing countries

    Directory of Open Access Journals (Sweden)

    Ravi Murugesan

    2017-03-01

    Full Text Available We report on an online course in research writing offered in a massive open online course (MOOC format for developing country researchers. The concepts of cognitive presence, teacher presence, and social presence informed the design of the course, with a philosophy of strong social interaction supported by guest facilitators. The course was developed with low-bandwidth elements and hosted on a Moodle site. It was offered twice as a MOOC and 2830 learners from more than 90 countries, mainly in the developing world, took part. The average completion rate was 53%. Female learners and learners who were active in the forums were more likely to complete the course. Our MOOC approach may be a useful model for continuing professional development training in the developing world.

  3. Development and application of earth system models

    OpenAIRE

    Prinn, Ronald G.

    2012-01-01

    The global environment is a complex and dynamic system. Earth system modeling is needed to help understand changes in interacting subsystems, elucidate the influence of human activities, and explore possible future changes. Integrated assessment of environment and human development is arguably the most difficult and most important “systems” problem faced. To illustrate this approach, we present results from the integrated global system model (IGSM), which consists of coupled submodels address...

  4. SCOS 2: An object oriented software development approach

    Science.gov (United States)

    Symonds, Martin; Lynenskjold, Steen; Mueller, Christian

    1994-01-01

    The Spacecraft Control and Operations System 2 (SCOS 2), is intended to provide the generic mission control system infrastructure for future ESA missions. It represents a bold step forward in order to take advantage of state-of-the-art technology and current practices in the area of software engineering. Key features include: (1) use of object oriented analysis and design techniques; (2) use of UNIX, C++ and a distributed architecture as the enabling implementation technology; (3) goal of re-use for development, maintenance and mission specific software implementation; and (4) introduction of the concept of a spacecraft control model. This paper touches upon some of the traditional beliefs surrounding Object Oriented development and describes their relevance to SCOS 2. It gives rationale for why particular approaches were adopted and others not, and describes the impact of these decisions. The development approach followed is discussed, highlighting the evolutionary nature of the overall process and the iterative nature of the various tasks carried out. The emphasis of this paper is on the process of the development with the following being covered: (1) the three phases of the SCOS 2 project - prototyping & analysis, design & implementation and configuration / delivery of mission specific systems; (2) the close cooperation and continual interaction with the users during the development; (3) the management approach - the split between client staff, industry and some of the required project management activities; (4) the lifecycle adopted being an enhancement of the ESA PSS-05 standard with SCOS 2 specific activities and approaches defined; and (5) an examination of some of the difficulties encountered and the solutions adopted. Finally, the lessons learned from the SCOS 2 experience are highlighted, identifying those issues to be used as feedback into future developments of this nature. This paper does not intend to describe the finished product and its operation

  5. Radioimmunotherapy: Development of an effective approach

    Energy Technology Data Exchange (ETDEWEB)

    DeNardo, S.J.

    1991-01-01

    We plan to extend our success in treating B cell malignancies with {sup 131}I labeled Lym-1 by a major effort in therapy with {sup 67}Cu Lym-1. Yttrium-90 labeled by a macrocycle, DOTA will be studied in patients as a continuation of the {sup 111}In-BAD (DOTA) Lym-1 studies. Excellent images and pharmacokinetics of the {sup 111}In-BAD(DOTA)-Lym-1 studies. Lymphomas and related diseases represent a special case for radioimmunotherapy because of their documented radiosensitivity and immunodeficiency, and thus offer a unique opportunity to conduct therapeutic feasibility studies in a responsive human model. Using marine and chimeric L6 and other MoAb to breast cancer, we have applied the strategies that were developed in taking Lym-1 antibody from the bench to the patient. We have examined a number of monoclonal antibodies for treatment of breast cancer and chose chimeric L6 for prototype studies because of certain characteristics. The chemistry of attachment of conjugates to antibodies and their impact on immunological targeting biological activities (cytotoxicity), metabolic fate, and therapeutic index will continue to be a major strength and function of this program. This grant has supported the conception, synthesis, and development of the first macrocylic, bifunctional chelating agent TETA (6-p-nitrobenzyl-1,4,8,11-tetraazatetradecane-N,N{prime},N{double prime}, N{prime}{double prime}-tetraacetic acid and its derivatives, including Lym-1-2IT-BAT), for use in Cu-67-based radioimmunodiagnosis and therapy. This work has led to the further development of several new macrocylic bifunctional chelating agents for copper, indium, yttrium and other metals. In addition, successful Cu-67 labelings of Lym-1-2IT-BAT for human radiopharmaceutical have shown patient pharmacokinetics of {sup 67}Cu-BAT(TETA)-Lym-1 with promising therapeutic dosimetry.

  6. Data-driven approach to identify field-scale biogeochemical transitions using geochemical and geophysical data and hidden Markov models: Development and application at a uranium-contaminated aquifer

    Science.gov (United States)

    Chen, Jinsong; Hubbard, Susan S.; Williams, Kenneth H.

    2013-10-01

    Although mechanistic reaction networks have been developed to quantify the biogeochemical evolution of subsurface systems associated with bioremediation, it is difficult in practice to quantify the onset and distribution of these transitions at the field scale using commonly collected wellbore datasets. As an alternative approach to the mechanistic methods, we develop a data-driven, statistical model to identify biogeochemical transitions using various time-lapse aqueous geochemical data (e.g., Fe(II), sulfate, sulfide, acetate, and uranium concentrations) and induced polarization (IP) data. We assume that the biogeochemical transitions can be classified as several dominant states that correspond to redox transitions and test the method at a uranium-contaminated site. The relationships between the geophysical observations and geochemical time series vary depending upon the unknown underlying redox status, which is modeled as a hidden Markov random field. We estimate unknown parameters by maximizing the joint likelihood function using the maximization-expectation algorithm. The case study results show that when considered together aqueous geochemical data and IP imaginary conductivity provide a key diagnostic signature of biogeochemical stages. The developed method provides useful information for evaluating the effectiveness of bioremediation, such as the probability of being in specific redox stages following biostimulation where desirable pathways (e.g., uranium removal) are more highly favored. The use of geophysical data in the approach advances the possibility of using noninvasive methods to monitor critical biogeochemical system stages and transitions remotely and over field relevant scales (e.g., from square meters to several hectares).

  7. Scientific Theories, Models and the Semantic Approach

    Directory of Open Access Journals (Sweden)

    Décio Krause

    2007-12-01

    Full Text Available According to the semantic view, a theory is characterized by a class of models. In this paper, we examine critically some of the assumptions that underlie this approach. First, we recall that models are models of something. Thus we cannot leave completely aside the axiomatization of the theories under consideration, nor can we ignore the metamathematics used to elaborate these models, for changes in the metamathematics often impose restrictions on the resulting models. Second, based on a parallel between van Fraassen’s modal interpretation of quantum mechanics and Skolem’s relativism regarding set-theoretic concepts, we introduce a distinction between relative and absolute concepts in the context of the models of a scientific theory. And we discuss the significance of that distinction. Finally, by focusing on contemporary particle physics, we raise the question: since there is no general accepted unification of the parts of the standard model (namely, QED and QCD, we have no theory, in the usual sense of the term. This poses a difficulty: if there is no theory, how can we speak of its models? What are the latter models of? We conclude by noting that it is unclear that the semantic view can be applied to contemporary physical theories.

  8. Continuous Competence Development Model for Teacher Teams

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke

    2014-01-01

    "This paper presents the development of the IT‐Pedagogical Think Tank for Teacher Teams (ITP4T), a continuous competence development model. The model was co‐designed following a design‐based research approach with teachers from VUC Storstrøm’s (VUC) Global Classroom (GC), an innovative hybrid...... synchronous videoconference concept (Weitze & Ørngreen 2014). The ITP4T model responds to the needs and challenges that the teachers and the organization in VUC’s GC are experiencing in the new technological teaching environment. Ultimately, it aims to create a new practise for teachers, enabling them...... to create their own continuous competence development. This article describes how and why the different components of the model were developed in response to the teachers’ challenges. Such challenges included lack of time, competence and support from the educational organisation to innovate learning design...

  9. A Behavioral Decision Making Modeling Approach Towards Hedging Services

    NARCIS (Netherlands)

    Pennings, J.M.E.; Candel, M.J.J.M.; Egelkraut, T.M.

    2003-01-01

    This paper takes a behavioral approach toward the market for hedging services. A behavioral decision-making model is developed that provides insight into how and why owner-managers decide the way they do regarding hedging services. Insight into those choice processes reveals information needed by fi

  10. Benchmarking novel approaches for modelling species range dynamics.

    Science.gov (United States)

    Zurell, Damaris; Thuiller, Wilfried; Pagel, Jörn; Cabral, Juliano S; Münkemüller, Tamara; Gravel, Dominique; Dullinger, Stefan; Normand, Signe; Schiffers, Katja H; Moore, Kara A; Zimmermann, Niklaus E

    2016-08-01

    Increasing biodiversity loss due to climate change is one of the most vital challenges of the 21st century. To anticipate and mitigate biodiversity loss, models are needed that reliably project species' range dynamics and extinction risks. Recently, several new approaches to model range dynamics have been developed to supplement correlative species distribution models (SDMs), but applications clearly lag behind model development. Indeed, no comparative analysis has been performed to evaluate their performance. Here, we build on process-based, simulated data for benchmarking five range (dynamic) models of varying complexity including classical SDMs, SDMs coupled with simple dispersal or more complex population dynamic models (SDM hybrids), and a hierarchical Bayesian process-based dynamic range model (DRM). We specifically test the effects of demographic and community processes on model predictive performance. Under current climate, DRMs performed best, although only marginally. Under climate change, predictive performance varied considerably, with no clear winners. Yet, all range dynamic models improved predictions under climate change substantially compared to purely correlative SDMs, and the population dynamic models also predicted reasonable extinction risks for most scenarios. When benchmarking data were simulated with more complex demographic and community processes, simple SDM hybrids including only dispersal often proved most reliable. Finally, we found that structural decisions during model building can have great impact on model accuracy, but prior system knowledge on important processes can reduce these uncertainties considerably. Our results reassure the clear merit in using dynamic approaches for modelling species' response to climate change but also emphasize several needs for further model and data improvement. We propose and discuss perspectives for improving range projections through combination of multiple models and for making these approaches

  11. Policy development: a more formal systems approach process

    CSIR Research Space (South Africa)

    Greeff, AP

    2011-09-01

    Full Text Available Policy developers in corporate and governance roles are often developing policies by means of policy development cycles that typically resemble a system life cycle approach. Although policy development cycles often vary, depending on the applicable...

  12. An algebraic approach to modeling in software engineering

    Energy Technology Data Exchange (ETDEWEB)

    Loegel, G.J. [Superconducting Super Collider Lab., Dallas, TX (United States)]|[Michigan Univ., Ann Arbor, MI (United States); Ravishankar, C.V. [Michigan Univ., Ann Arbor, MI (United States)

    1993-09-01

    Our work couples the formalism of universal algebras with the engineering techniques of mathematical modeling to develop a new approach to the software engineering process. Our purpose in using this combination is twofold. First, abstract data types and their specification using universal algebras can be considered a common point between the practical requirements of software engineering and the formal specification of software systems. Second, mathematical modeling principles provide us with a means for effectively analyzing real-world systems. We first use modeling techniques to analyze a system and then represent the analysis using universal algebras. The rest of the software engineering process exploits properties of universal algebras that preserve the structure of our original model. This paper describes our software engineering process and our experience using it on both research and commercial systems. We need a new approach because current software engineering practices often deliver software that is difficult to develop and maintain. Formal software engineering approaches use universal algebras to describe ``computer science`` objects like abstract data types, but in practice software errors are often caused because ``real-world`` objects are improperly modeled. There is a large semantic gap between the customer`s objects and abstract data types. In contrast, mathematical modeling uses engineering techniques to construct valid models for real-world systems, but these models are often implemented in an ad hoc manner. A combination of the best features of both approaches would enable software engineering to formally specify and develop software systems that better model real systems. Software engineering, like mathematical modeling, should concern itself first and foremost with understanding a real system and its behavior under given circumstances, and then with expressing this knowledge in an executable form.

  13. A Multivariate Approach to Functional Neuro Modeling

    DEFF Research Database (Denmark)

    Mørch, Niels J.S.

    1998-01-01

    This Ph.D. thesis, A Multivariate Approach to Functional Neuro Modeling, deals with the analysis and modeling of data from functional neuro imaging experiments. A multivariate dataset description is provided which facilitates efficient representation of typical datasets and, more importantly...... and overall conditions governing the functional experiment, via associated micro- and macroscopic variables. The description facilitates an efficient microscopic re-representation, as well as a handle on the link between brain and behavior; the latter is achieved by hypothesizing variations in the micro...... a generalization theoretical framework centered around measures of model generalization error. - Only few, if any, examples of the application of generalization theory to functional neuro modeling currently exist in the literature. - Exemplification of the proposed generalization theoretical framework...

  14. Real-space renormalization group approach to the Anderson model

    Science.gov (United States)

    Campbell, Eamonn

    Many of the most interesting electronic behaviours currently being studied are associated with strong correlations. In addition, many of these materials are disordered either intrinsically or due to doping. Solving interacting systems exactly is extremely computationally expensive, and approximate techniques developed for strongly correlated systems are not easily adapted to include disorder. As a non-interacting disordered model, it makes sense to consider the Anderson model as a first step in developing an approximate method of solution to the interacting and disordered Anderson-Hubbard model. Our renormalization group (RG) approach is modeled on that proposed by Johri and Bhatt [23]. We found an error in their work which we have corrected in our procedure. After testing the execution of the RG, we benchmarked the density of states and inverse participation ratio results against exact diagonalization. Our approach is significantly faster than exact diagonalization and is most accurate in the limit of strong disorder.

  15. The applying stakeholder approach to strategic management of territories development

    Directory of Open Access Journals (Sweden)

    Ilshat Azamatovich Tazhitdinov

    2013-06-01

    Full Text Available In the paper, the aspects of the strategic management of socioeconomic development of territories in terms of stakeholder approach are discussed. The author's interpretation of the concept of stakeholder sub-region is proposed, and their classification into internal and external to the territorial socioeconomic system of sub-regional level is offered. The types of interests and types of resources stakeholders in the sub-region are identified, and at the same time the correlation of interests and resources allows to determine the groups (alliances stakeholders, which ensure the balance of interests depending on the certain objectives of the association. The conceptual stakeholder agent model of management of strategic territorial development within the hierarchical system of «region — sub-region — municipal formation,» is proposed. All stakeholders there are considered as the influence agents directing its own resources to provide a comprehensive approach to management territorial development. The interaction between all the influence agents of the «Region — Sub-region — municipal formation» is provided vertically and horizontally through the initialization of the development and implementation of strategic documents of the sub-region. Vertical interaction occurs between stakeholders such as government and municipal authorities being as a guideline, and the horizontal — between the rests of them being as a partnership. Within the proposed model, the concurrent engineering is implemented, which is a form of inter-municipal strategic cooperation of local government municipalities for the formation and analyzing a set of alternatives of the project activities in the sub-region in order to choose the best options. The proposed approach was tested in the development of medium-term comprehensive program of socioeconomic development of the Zauralye and sub-regions of the North-East of the Republic of Bashkortostan (2011–2015.

  16. A Participatory Systemic Approach To Rural Community Development In Vietnam

    Directory of Open Access Journals (Sweden)

    Tuan M. Ha

    2015-08-01

    Full Text Available Various failures of the traditional approach in community development in developing countries have led to the development of a more appropriate and holistic approach to address complex development issues. Systems approaches and cutting-edge tools have recently been embraced to deal with such complexities under contexts of interwoven relationships amongst social economic political cultural and environmental factors. This paper provides reflections on practical value of the Evolutionary Learning Laboratory ELLab through a case study on improving the quality of life for women farmers in northern Vietnam where gender-bias labour hardship and poor living-standard are evident. The first five steps of the participatory systems-based ELLab were implemented during 2013-2014 providing valuable results that have made both practical and theoretical contributions with substantial implications to community development. Our study finds that the context-based results reshaped the original project goal. The approach and framework helped to identify and engage right stakeholders in problem analyses and decision making activities. Fuzzy problems within the complex web of life of the women and rural households were uncovered using relevant systems tools to develop a big picture systems model of the current situation defining levers for systemic interventions. The ELLab helps to build capacity of local people for taking ownership of the process and outcomes to guarantee sustainability and long-term impacts. It also facilitates true participation and co-learning amongst stakeholders triggering transformative learning. Contributions to action research and an innovative mechanism for sharing reflections and lessons at both local and global levels via the online Think2ImpactTM are discussed.

  17. Consumer preference models: fuzzy theory approach

    Science.gov (United States)

    Turksen, I. B.; Wilson, I. A.

    1993-12-01

    Consumer preference models are widely used in new product design, marketing management, pricing and market segmentation. The purpose of this article is to develop and test a fuzzy set preference model which can represent linguistic variables in individual-level models implemented in parallel with existing conjoint models. The potential improvements in market share prediction and predictive validity can substantially improve management decisions about what to make (product design), for whom to make it (market segmentation) and how much to make (market share prediction).

  18. Dynamic Metabolic Model Building Based on the Ensemble Modeling Approach

    Energy Technology Data Exchange (ETDEWEB)

    Liao, James C. [Univ. of California, Los Angeles, CA (United States)

    2016-10-01

    Ensemble modeling of kinetic systems addresses the challenges of kinetic model construction, with respect to parameter value selection, and still allows for the rich insights possible from kinetic models. This project aimed to show that constructing, implementing, and analyzing such models is a useful tool for the metabolic engineering toolkit, and that they can result in actionable insights from models. Key concepts are developed and deliverable publications and results are presented.

  19. Assessment of global flood exposures - developing an appropriate approach

    Science.gov (United States)

    Millinship, Ian; Booth, Naomi

    2015-04-01

    Increasingly complex probabilistic catastrophe models have become the standard for quantitative flood risk assessments by re/insurance companies. On the one hand, probabilistic modelling of this nature is extremely useful; a large range of risk metrics can be output. However, they can be time consuming and computationally expensive to develop and run. Levels of uncertainty are persistently high despite, or perhaps because of, attempts to increase resolution and complexity. A cycle of dependency between modelling companies and re/insurers has developed whereby available models are purchased, models run, and both portfolio and model data 'improved' every year. This can lead to potential exposures in perils and territories that are not currently modelled being largely overlooked by companies, who may then face substantial and unexpected losses when large events occur in these areas. We present here an approach to assessing global flood exposures which reduces the scale and complexity of approach used and begins with the identification of hotspots where there is a significant exposure to flood risk. The method comprises four stages: i) compile consistent exposure information, ii) to apply reinsurance terms and conditions to calculate values exposed, iii) to assess the potential hazard using a global set of flood hazard maps, and iv) to identify potential risk 'hotspots' which include considerations of spatially and/or temporally clustered historical events, and local flood defences. This global exposure assessment is designed as a scoping exercise, and reveals areas or cities where the potential for accumulated loss is of significant interest to a reinsurance company, and for which there is no existing catastrophe model. These regions are then candidates for the development of deterministic scenarios, or probabilistic models. The key advantages of this approach will be discussed. These include simplicity and ability of business leaders to understand results, as well as

  20. Modeling software with finite state machines a practical approach

    CERN Document Server

    Wagner, Ferdinand; Wagner, Thomas; Wolstenholme, Peter

    2006-01-01

    Modeling Software with Finite State Machines: A Practical Approach explains how to apply finite state machines to software development. It provides a critical analysis of using finite state machines as a foundation for executable specifications to reduce software development effort and improve quality. This book discusses the design of a state machine and of a system of state machines. It also presents a detailed analysis of development issues relating to behavior modeling with design examples and design rules for using finite state machines. This volume describes a coherent and well-tested fr

  1. Teaching Service Modelling to a Mixed Class: An Integrated Approach

    Directory of Open Access Journals (Sweden)

    Jeremiah D. DENG

    2015-04-01

    Full Text Available Service modelling has become an increasingly important area in today's telecommunications and information systems practice. We have adapted a Network Design course in order to teach service modelling to a mixed class of both the telecommunication engineering and information systems backgrounds. An integrated approach engaging mathematics teaching with strategies such as problem-solving, visualization, and the use of examples and simulations, has been developed. From assessment on student learning outcomes, it is indicated that the proposed course delivery approach succeeded in bringing out comparable and satisfactory performance from students of different educational backgrounds.

  2. A team building approach for competency development.

    OpenAIRE

    Hlaoittinun, Onanong; Bonjour, Eric; Dulmet, Maryvonne

    2007-01-01

    International audience; An approach for multidisciplinary team building is proposed through three steps. We suppose that tasks and team members are characterized by a set of attributes (technical competencies). First, the calculation of distance measure between task and team member (profile matching) are proposed. Second, an array-based clustering algorithm is used as an effective means for providing an alternative solution in task and team-member clustering. The proposed approach generates a...

  3. Radioimmunotherapy: Development of an effective approach. Progress report, 1987

    Energy Technology Data Exchange (ETDEWEB)

    1987-12-31

    Goals of this program are to answer the fundamental scientific questions for the development of an effective approach for delivering radiation therapy to cancer on antibody-based radiopharmaceuticals. The following list consists of highlights of developments from our program: documented therapeutic response of lymphoma in patients receiving radioimmunotherapy; development and application of quantitative radionuclide imaging techniques for therapy planning and dosimetry calculations; multicompartmental modeling and analysis of the in vivo MoAb kinetics in patients; a MoAb macrocycle chelate for Cu-67: development, production, in vitro and in vivo testing; NMR analysis of immunoradiotherapeutic effects on the metabolism of lymphoma; analysis of the variable molecular characteristics of the MoAb radiopharmaceutical, and their significance; in vivo studies in mice and patients of the metabolism of radioiodinated MoAb as well as In-111 CITC MoAb; and biodistribution of Cu-67 TETA MoAb in nude mice with human lymphoma.

  4. Advanced Mirror & Modelling Technology Development

    Science.gov (United States)

    Effinger, Michael; Stahl, H. Philip; Abplanalp, Laura; Maffett, Steven; Egerman, Robert; Eng, Ron; Arnold, William; Mosier, Gary; Blaurock, Carl

    2014-01-01

    The 2020 Decadal technology survey is starting in 2018. Technology on the shelf at that time will help guide selection to future low risk and low cost missions. The Advanced Mirror Technology Development (AMTD) team has identified development priorities based on science goals and engineering requirements for Ultraviolet Optical near-Infrared (UVOIR) missions in order to contribute to the selection process. One key development identified was lightweight mirror fabrication and testing. A monolithic, stacked, deep core mirror was fused and replicated twice to achieve the desired radius of curvature. It was subsequently successfully polished and tested. A recently awarded second phase to the AMTD project will develop larger mirrors to demonstrate the lateral scaling of the deep core mirror technology. Another key development was rapid modeling for the mirror. One model focused on generating optical and structural model results in minutes instead of months. Many variables could be accounted for regarding the core, face plate and back structure details. A portion of a spacecraft model was also developed. The spacecraft model incorporated direct integration to transform optical path difference to Point Spread Function (PSF) and between PSF to modulation transfer function. The second phase to the project will take the results of the rapid mirror modeler and integrate them into the rapid spacecraft modeler.

  5. Comparative flood damage model assessment: towards a European approach

    Directory of Open Access Journals (Sweden)

    B. Jongman

    2012-12-01

    Full Text Available There is a wide variety of flood damage models in use internationally, differing substantially in their approaches and economic estimates. Since these models are being used more and more as a basis for investment and planning decisions on an increasingly large scale, there is a need to reduce the uncertainties involved and develop a harmonised European approach, in particular with respect to the EU Flood Risks Directive. In this paper we present a qualitative and quantitative assessment of seven flood damage models, using two case studies of past flood events in Germany and the United Kingdom. The qualitative analysis shows that modelling approaches vary strongly, and that current methodologies for estimating infrastructural damage are not as well developed as methodologies for the estimation of damage to buildings. The quantitative results show that the model outcomes are very sensitive to uncertainty in both vulnerability (i.e. depth–damage functions and exposure (i.e. asset values, whereby the first has a larger effect than the latter. We conclude that care needs to be taken when using aggregated land use data for flood risk assessment, and that it is essential to adjust asset values to the regional economic situation and property characteristics. We call for the development of a flexible but consistent European framework that applies best practice from existing models while providing room for including necessary regional adjustments.

  6. The Chrysler-Weldtech Approach to Retraining Displaced Workers. A Model Project to Develop Specialized Welding Skills Required for Modern Auto Assembly Operations. Final Technical Report.

    Science.gov (United States)

    Lyons, Thomas M.; Knight, Glen A.

    A model project was conducted to demonstrate how Chrysler, in partnership with the education community and the government, could provide technical training to enable displaced workers to contribute to the "H-Body" car launch, to improve their job skills, and to enhance their future employability. The training was conducted on a pilot basis for 2…

  7. Standardized approach for developing probabilistic exposure factor distributions

    Energy Technology Data Exchange (ETDEWEB)

    Maddalena, Randy L.; McKone, Thomas E.; Sohn, Michael D.

    2003-03-01

    The effectiveness of a probabilistic risk assessment (PRA) depends critically on the quality of input information that is available to the risk assessor and specifically on the probabilistic exposure factor distributions that are developed and used in the exposure and risk models. Deriving probabilistic distributions for model inputs can be time consuming and subjective. The absence of a standard approach for developing these distributions can result in PRAs that are inconsistent and difficult to review by regulatory agencies. We present an approach that reduces subjectivity in the distribution development process without limiting the flexibility needed to prepare relevant PRAs. The approach requires two steps. First, we analyze data pooled at a population scale to (1) identify the most robust demographic variables within the population for a given exposure factor, (2) partition the population data into subsets based on these variables, and (3) construct archetypal distributions for each subpopulation. Second, we sample from these archetypal distributions according to site- or scenario-specific conditions to simulate exposure factor values and use these values to construct the scenario-specific input distribution. It is envisaged that the archetypal distributions from step 1 will be generally applicable so risk assessors will not have to repeatedly collect and analyze raw data for each new assessment. We demonstrate the approach for two commonly used exposure factors--body weight (BW) and exposure duration (ED)--using data for the U.S. population. For these factors we provide a first set of subpopulation based archetypal distributions along with methodology for using these distributions to construct relevant scenario-specific probabilistic exposure factor distributions.

  8. Innovative approaches to clinical development and trial design

    Directory of Open Access Journals (Sweden)

    John J Orloff

    2011-01-01

    Full Text Available Pharmaceutical innovation is increasingly risky, costly and at times inefficient, which has led to a decline in industry productivity. Despite the increased investment in R&D by the industry, the number of new molecular entities achieving marketing authorization is not increasing. Novel approaches to clinical development and trial design could have a key role in overcoming some of these challenges by improving efficiency and reducing attrition rates. The effectiveness of clinical development can be improved by adopting a more integrated model that increases flexibility and maximizes the use of accumulated knowledge. Central to this model of drug development are novel tools, including modelling and simulation, Bayesian methodologies, and adaptive designs, such as seamless adaptive designs and sample-size re-estimation methods. Applications of these methodologies to early- and late-stage drug development are described with some specific examples, along with advantages, challenges, and barriers to implementation. Because they are so flexible, these new trial designs require significant statistical analyses, simulations and logistical considerations to verify their operating characteristics, and therefore tend to require more time for the planning and protocol development phase. Greater awareness of the distinct advantages of innovative designs by regulators and sponsors are crucial to increasing the adoption of these modern tools.

  9. Space Flight Cable Model Development

    Science.gov (United States)

    Spak, Kaitlin

    2013-01-01

    This work concentrates the modeling efforts presented in last year's VSGC conference paper, "Model Development for Cable-Harnessed Beams." The focus is narrowed to modeling of space-flight cables only, as a reliable damped cable model is not yet readily available and is necessary to continue modeling cable-harnessed space structures. New experimental data is presented, eliminating the low-frequency noise that plagued the first year's efforts. The distributed transfer function method is applied to a single section of space flight cable for Euler-Bernoulli and shear beams. The work presented here will be developed into a damped cable model that can be incorporated into an interconnected beam-cable system. The overall goal of this work is to accurately predict natural frequencies and modal damping ratios for cabled space structures.

  10. Building enterprise reuse program--A model-based approach

    Institute of Scientific and Technical Information of China (English)

    梅宏; 杨芙清

    2002-01-01

    Reuse is viewed as a realistically effective approach to solving software crisis. For an organization that wants to build a reuse program, technical and non-technical issues must be considered in parallel. In this paper, a model-based approach to building systematic reuse program is presented. Component-based reuse is currently a dominant approach to software reuse. In this approach, building the right reusable component model is the first important step. In order to achieve systematic reuse, a set of component models should be built from different perspectives. Each of these models will give a specific view of the components so as to satisfy different needs of different persons involved in the enterprise reuse program. There already exist some component models for reuse from technical perspectives. But less attention is paid to the reusable components from a non-technical view, especially from the view of process and management. In our approach, a reusable component model--FLP model for reusable component--is introduced. This model describes components from three dimensions (Form, Level, and Presentation) and views components and their relationships from the perspective of process and management. It determines the sphere of reusable components, the time points of reusing components in the development process, and the needed means to present components in terms of the abstraction level, logic granularity and presentation media. Being the basis on which the management and technical decisions are made, our model will be used as the kernel model to initialize and normalize a systematic enterprise reuse program.

  11. Sulfur mustard-stimulated proteases and their inhibitors in a cultured normal human epidermal keratinocytes model: A potential approach for anti-vesicant drug development

    Directory of Open Access Journals (Sweden)

    Xiannu Jin

    2016-01-01

    To summarize, our results in the NHEK model indicate the following: (a SM stimulates multiple proteases including serine protease(s, and metalloproteases; (b SM decreases the level of laminin-5 γ2, which is prevented by either a serine protease inhibitor or a metalloprotease inhibitor and (c MT-MMP-1 maybe one of the proteases that is involved in skin blistering due to SM exposure.

  12. The Development of Sugar Beet Production and Processing Simulation Model – a System Dynamics Approach to Support Decision-Making Processes

    Directory of Open Access Journals (Sweden)

    Rozman Črtomir

    2014-05-01

    Full Text Available Background: The sugar beet is the main field crop used for sugar production in the temperate climatic zone. The abolishment of the quota system will open new investment opportunities in countries that were forced to abandon sugar industry as the result of the reform in 2006. Present paper describes the modeling of sugar beet production and its processing into sugar for purpose of decision support.

  13. Modeling continuity and discontinuity in utterance length : a quantitative approach to changes, transitions and intra-individual variability in early grammatical development

    NARCIS (Netherlands)

    Bassano, Dominique; van Geert, Paul

    2007-01-01

    The confluence of an anomaly such as a growth spurt or a temporary regression on the one hand and a temporary increase in intra-individual variability on the other hand, forms a strong indicator of a major transition in early language development. Data concern one-word (W1), two- and three-word (W2-

  14. Numerical modelling of the turbulent flow developing within and over a 3-d building array, part iii: a istributed drag force approach, its implementation and application

    Science.gov (United States)

    Lien, Fue-Sang; Yee, Eugene

    A modified k- model is used for the simulation of the mean wind speed and turbulence for a neutrally-stratified flow through and over a building array, where the array is treated as a porous medium with the drag on the unresolved buildings in the array represented by a distributed momentum sink. More specifically, this model is based on time averaging the spatially averaged Navier-Stokes equation, in which the effects of the obstacle-atmosphere interaction are included through the introduction of a distributed mean-momentum sink (representing drag on the unresolved buildings in the array). In addition, closure of the time-averaged, spatially averaged Navier-Stokes equation requires two additional prognostic equations, namely one for the time-averaged resolved-scale kinetic energy of turbulence,, and another for its dissipation rate, . The performance of the proposed model and some simplified versions derived from it is compared with the spatially averaged, time-mean velocity and various spatially averaged Reynolds stresses diagnosed from a high-resolution computational fluid dynamics (CFD) simulation of the flow within and over an aligned array of sharp-edged cubes with a plan area density of 0.25. Four different methods for diagnosis of the drag coefficient CDfor the aligned cube array, required for the volumetric drag force representation of the cubes, are investigated here. We found that the model predictions for mean wind speed and turbulence in the building array were not sensitive to the differing treatments of the source and sink terms in the and equations (e.g., inclusion of only the `zeroth-order'' approximation for the source/sink terms compared with inclusion of a higher-order approximation for the source/sink terms in the and equations), implying that the higher-order approximations of these source/sink terms did not offer any predictive advantage. A possible explanation for this is the utilization of the Boussinesq linear stress-strain constitutive

  15. A new approach for Bayesian model averaging

    Institute of Scientific and Technical Information of China (English)

    TIAN XiangJun; XIE ZhengHui; WANG AiHui; YANG XiaoChun

    2012-01-01

    Bayesian model averaging (BMA) is a recently proposed statistical method for calibrating forecast ensembles from numerical weather models.However,successful implementation of BMA requires accurate estimates of the weights and variances of the individual competing models in the ensemble.Two methods,namely the Expectation-Maximization (EM) and the Markov Chain Monte Carlo (MCMC) algorithms,are widely used for BMA model training.Both methods have their own respective strengths and weaknesses.In this paper,we first modify the BMA log-likelihood function with the aim of removing the additional limitation that requires that the BMA weights add to one,and then use a limited memory quasi-Newtonian algorithm for solving the nonlinear optimization problem,thereby formulating a new approach for BMA (referred to as BMA-BFGS).Several groups of multi-model soil moisture simulation experiments from three land surface models show that the performance of BMA-BFGS is similar to the MCMC method in terms of simulation accuracy,and that both are superior to the EM algorithm.On the other hand,the computational cost of the BMA-BFGS algorithm is substantially less than for MCMC and is almost equivalent to that for EM.

  16. "Dispersion modeling approaches for near road | Science ...

    Science.gov (United States)

    Roadway design and roadside barriers can have significant effects on the dispersion of traffic-generated pollutants, especially in the near-road environment. Dispersion models that can accurately simulate these effects are needed to fully assess these impacts for a variety of applications. For example, such models can be useful for evaluating the mitigation potential of roadside barriers in reducing near-road exposures and their associated adverse health effects. Two databases, a tracer field study and a wind tunnel study, provide measurements used in the development and/or validation of algorithms to simulate dispersion in the presence of noise barriers. The tracer field study was performed in Idaho Falls, ID, USA with a 6-m noise barrier and a finite line source in a variety of atmospheric conditions. The second study was performed in the meteorological wind tunnel at the US EPA and simulated line sources at different distances from a model noise barrier to capture the effect on emissions from individual lanes of traffic. In both cases, velocity and concentration measurements characterized the effect of the barrier on dispersion.This paper presents comparisons with the two datasets of the barrier algorithms implemented in two different dispersion models: US EPA’s R-LINE (a research dispersion modelling tool under development by the US EPA’s Office of Research and Development) and CERC’s ADMS model (ADMS-Urban). In R-LINE the physical features reveal

  17. Project Report on Development of a Safeguards Approach for Pyroprocessing

    Energy Technology Data Exchange (ETDEWEB)

    Robert Bean

    2010-09-01

    The Idaho National Laboratory has undertaken an effort to develop a standard safeguards approach for international commercial pyroprocessing facilities. This report details progress for the fiscal year 2010 effort. A component by component diversion pathway analysis has been performed, and has led to insight on the mitigation needs and equipment development needed for a valid safeguards approach. The effort to develop an in-hot cell detection capability led to the digital cloud chamber, and more importantly, the significant potential scientific breakthrough of the inverse spectroscopy algorithm, including the ability to identify energy and spatial location of gamma ray emitting sources with a single, non-complex, stationary radiation detector system. Curium measurements were performed on historical and current samples at the FCF to attempt to determine the utility of using gross neutron counting for accountancy measurements. A solid cost estimate of equipment installation at FCF has been developed to guide proposals and cost allocations to use FCF as a test bed for safeguards measurement demonstrations. A combined MATLAB and MCNPX model has been developed to perform detector placement calculations around the electrorefiner. Early harvesting has occurred wherein the project team has been requested to provide pyroprocessing technology and safeguards short courses.

  18. PDF approach for turbulent scalar field: Some recent developments

    Science.gov (United States)

    Gao, Feng

    1993-01-01

    The probability density function (PDF) method has been proven a very useful approach in turbulence research. It has been particularly effective in simulating turbulent reacting flows and in studying some detailed statistical properties generated by a turbulent field There are, however, some important questions that have yet to be answered in PDF studies. Our efforts in the past year have been focused on two areas. First, a simple mixing model suitable for Monte Carlo simulations has been developed based on the mapping closure. Secondly, the mechanism of turbulent transport has been analyzed in order to understand the recently observed abnormal PDF's of turbulent temperature fields generated by linear heat sources.

  19. Applying the Cultural Approach to Cognitive Development

    Science.gov (United States)

    Gauvain, Mary; Beebe, Heidi; Zhao, Shuheng

    2011-01-01

    Cognitive development is a cultural process. More experienced cultural members and the practices, institutions, and artifacts of the culture provide support and guidance for children as they develop knowledge and thinking skills. In this article, the authors describe the value that is added to our understanding of cognitive development when…

  20. Applying the Cultural Approach to Cognitive Development

    Science.gov (United States)

    Gauvain, Mary; Beebe, Heidi; Zhao, Shuheng

    2011-01-01

    Cognitive development is a cultural process. More experienced cultural members and the practices, institutions, and artifacts of the culture provide support and guidance for children as they develop knowledge and thinking skills. In this article, the authors describe the value that is added to our understanding of cognitive development when…

  1. The use of health economics to guide drug development decisions: Determining optimal values for an RSV-vaccine in a model-based scenario-analytic approach.

    Science.gov (United States)

    Bos, J M; Rietveld, E; Moll, H A; Steyerberg, E W; Luytjes, W; Wilschut, J C; de Groot, R; Postma, M J

    2007-09-28

    Health-economic modelling is useful for assessing the clinical requirements and impact of new vaccines. In this study, we estimate the impact of potential vaccination for respiratory syncytial virus (RSV) of infants in the Netherlands. A decision analysis model was employed using seasonal data from a cohort of children (1996-1997 through 1999-2000) to assess hospitalisation, costs and impact of vaccination. Yearly, an estimated 3670 infants are hospitalised with RSV-infection in the Netherlands, vaccination protecting infants from 3 months of life onwards could prevent approximately 1000-3000 hospitalisations, depending on the effectiveness of the potential vaccine. Additionally, vaccination could prevent a major share of RSV-related costs. Comparison of the calculated break-even prices with the average price of recently introduced vaccines indicates that pricing for a potential RSV-vaccine most likely allows for only a single dose vaccination or several doses at a relatively low price per dose in order to achieve cost savings. However, if evidence on relevant RSV-related mortality would become available, higher pricing would be justified, while still remaining below accepted thresholds for cost-effectiveness.

  2. Development of a functional approach in a grassland vegetation sub-model = Desenvolvimento de uma abordagem funcional em um submodelo vegetal campestre

    Directory of Open Access Journals (Sweden)

    Jean-François Soussana

    2008-04-01

    Full Text Available To improve our understanding of grassland dynamics under different levels of utilization, a functional description of the vegetation was introduced in a deterministic model. The selected traits and their parameterization were based on the results of a longtermexperiment in which temperate grasslands were managed for 12 years with three levels of herbage use: high, medium and low. The integration of functional attributes of the community species within the model’s parameters can be seen as a new step in the study ofthe grassland ecosystem. With this tool, it is possible to decrease the number of interconnections in the system and consequently decrease the complexity. In this work a, functional definition of three different grassland communities was introduced into the subvegetation model. This was done by interchanging the model’s parameters with the functional attributes of the communities. From the conceptual point of view, the subvegetation model works adequately and it seems suitable to simulate the dynamic ofgrassland vegetation described by functional traits. The model fits experimental data well for high levels of utilization, but was poorly adjusted at medium and low levels of herbage use. We believe this is due to a better simulation of green biomass fluxes than forsenescence or reproductive fluxes. Some possible improvements of the model are discussed.Para aumentar a nossa compreensão sobre a dinâmica da vegetação campestre em diferentes níveis de utilização, foi introduzido num modelo determinístico uma descrição funcional da vegetação. Os atributos funcionais escolhidos e suas parametrizações foram baseadosem resultados de experimento de longo prazo, no qual pastagens temperadas foram manejadas por 12 anos com três níveis de utilização: alto, médio e baixo. A integração de atributos funcionais da comunidade vegetal nos parâmetros do modelo pode ser vista como um novo passo no estudo de ecossistemas pastoris

  3. Developing a Forensic Continuous Audit Model

    Directory of Open Access Journals (Sweden)

    Grover S. Kearns

    2011-06-01

    Full Text Available Despite increased attention to internal controls and risk assessment, traditional audit approaches do not seem to be highly effective in uncovering the majority of frauds. Less than 20 percent of all occupational frauds are uncovered by auditors. Forensic accounting has recognized the need for automated approaches to fraud analysis yet research has not examined the benefits of forensic continuous auditing as a method to detect and deter corporate fraud. The purpose of this paper is to show how such an approach is possible. A model is presented that supports the acceptance of forensic continuous auditing by auditors and management as an effective tool to support the audit function, meet management’s regulatory objectives, and to combat fraud. An approach to developing such a system is presented.

  4. Program Management Approach to the Territorial Development of Small Business

    Directory of Open Access Journals (Sweden)

    Natalia Aleksandrovna Knysh

    2016-06-01

    Full Text Available This article presents the results of the research of the application on a state level of the program management approach to the territorial development of small business. Studying the main mechanism of the state policy implementation in the sphere of small business on a regional level, the authors have revealed the necessity to take into account the territorial specificity while the government programs of small business development are being formed. The analysis of the national practice of utilizing the program management mechanism in the regional system of the government support of small entrepreneurship was conducted on the example of Omsk region. The results of the analysis have shown the inefficiency of the current support system for small business and have determined the need to create an integrated model of territorial programming, which would not only contribute to the qualitative development of small business, but also provide the functioning efficiency of program management mechanism. As a result, the authors have created the two-level model of the programming of the territorial development of small business, which allows to satisfy purposefully the needs of entrepreneurship taking into account the specificity of the internal and external environment of the region. The first level of the model is methodological one and it is based on the marketing approach (the concepts of place marketing and relationship marketing to the operation of the program management mechanism. The second level of the model is methodical one. It offers the combination of the flexible methods of management of programming procedure (benchmarking, foresight, crowdsourcing and outsourcing. The given model raises the efficiency of the management decisions of the state structures in the sphere of small business. Therefore, it is interesting for the government authorities, which are responsible for the regional and municipal support programs of small business, as well

  5. AN AUTOMATIC APPROACH TO BOX & JENKINS MODELLING

    OpenAIRE

    MARCELO KRIEGER

    1983-01-01

    Apesar do reconhecimento amplo da qualidade das previsões obtidas na aplicação de um modelo ARIMA à previsão de séries temporais univariadas, seu uso tem permanecido restrito pela falta de procedimentos automáticos, computadorizados. Neste trabalho este problema é discutido e um algoritmo é proposto. Inspite of general recognition of the good forecasting ability of ARIMA models in predicting time series, this approach is not widely used because of the lack of ...

  6. Modeling in transport phenomena a conceptual approach

    CERN Document Server

    Tosun, Ismail

    2007-01-01

    Modeling in Transport Phenomena, Second Edition presents and clearly explains with example problems the basic concepts and their applications to fluid flow, heat transfer, mass transfer, chemical reaction engineering and thermodynamics. A balanced approach is presented between analysis and synthesis, students will understand how to use the solution in engineering analysis. Systematic derivations of the equations and the physical significance of each term are given in detail, for students to easily understand and follow up the material. There is a strong incentive in science and engineering to

  7. A model selection approach to analysis of variance and covariance.

    Science.gov (United States)

    Alber, Susan A; Weiss, Robert E

    2009-06-15

    An alternative to analysis of variance is a model selection approach where every partition of the treatment means into clusters with equal value is treated as a separate model. The null hypothesis that all treatments are equal corresponds to the partition with all means in a single cluster. The alternative hypothesis correspond to the set of all other partitions of treatment means. A model selection approach can also be used for a treatment by covariate interaction, where the null hypothesis and each alternative correspond to a partition of treatments into clusters with equal covariate effects. We extend the partition-as-model approach to simultaneous inference for both treatment main effect and treatment interaction with a continuous covariate with separate partitions for the intercepts and treatment-specific slopes. The model space is the Cartesian product of the intercept partition and the slope partition, and we develop five joint priors for this model space. In four of these priors the intercept and slope partition are dependent. We advise on setting priors over models, and we use the model to analyze an orthodontic data set that compares the frictional resistance created by orthodontic fixtures. Copyright (c) 2009 John Wiley & Sons, Ltd.

  8. Development of in Silico Models for Predicting P-Glycoprotein Inhibitors Based on a Two-Step Approach for Feature Selection and Its Application to Chinese Herbal Medicine Screening.

    Science.gov (United States)

    Yang, Ming; Chen, Jialei; Shi, Xiufeng; Xu, Liwen; Xi, Zhijun; You, Lisha; An, Rui; Wang, Xinhong

    2015-10-01

    P-glycoprotein (P-gp) is regarded as an important factor in determining the ADMET (absorption, distribution, metabolism, elimination, and toxicity) characteristics of drugs and drug candidates. Successful prediction of P-gp inhibitors can thus lead to an improved understanding of the underlying mechanisms of both changes in the pharmacokinetics of drugs and drug-drug interactions. Therefore, there has been considerable interest in the development of in silico modeling of P-gp inhibitors in recent years. Considering that a large number of molecular descriptors are used to characterize diverse structural moleculars, efficient feature selection methods are required to extract the most informative predictors. In this work, we constructed an extensive available data set of 2428 molecules that includes 1518 P-gp inhibitors and 910 P-gp noninhibitors from multiple resources. Importantly, a two-step feature selection approach based on a genetic algorithm and a greedy forward-searching algorithm was employed to select the minimum set of the most informative descriptors that contribute to the prediction of P-gp inhibitors. To determine the best machine learning algorithm, 18 classifiers coupled with the feature selection method were compared. The top three best-performing models (flexible discriminant analysis, support vector machine, and random forest) and their ensemble model using respectively only 3, 9, 7, and 14 descriptors achieve an overall accuracy of 83.2%-86.7% for the training set containing 1040 compounds, an overall accuracy of 82.3%-85.5% for the test set containing 1039 compounds, and a prediction accuracy of 77.4%-79.9% for the external validation set containing 349 compounds. The models were further extensively validated by DrugBank database (1890 compounds). The proposed models are competitive with and in some cases better than other published models in terms of prediction accuracy and minimum number of descriptors. Applicability domain then was addressed

  9. Modeling for fairness: A Rawlsian approach.

    Science.gov (United States)

    Diekmann, Sven; Zwart, Sjoerd D

    2014-06-01

    In this paper we introduce the overlapping design consensus for the construction of models in design and the related value judgments. The overlapping design consensus is inspired by Rawls' overlapping consensus. The overlapping design consensus is a well-informed, mutual agreement among all stakeholders based on fairness. Fairness is respected if all stakeholders' interests are given due and equal attention. For reaching such fair agreement, we apply Rawls' original position and reflective equilibrium to modeling. We argue that by striving for the original position, stakeholders expel invalid arguments, hierarchies, unwarranted beliefs, and bargaining effects from influencing the consensus. The reflective equilibrium requires that stakeholders' beliefs cohere with the final agreement and its justification. Therefore, the overlapping design consensus is not only an agreement to decisions, as most other stakeholder approaches, it is also an agreement to their justification and that this justification is consistent with each stakeholders' beliefs. For supporting fairness, we argue that fairness qualifies as a maxim in modeling. We furthermore distinguish values embedded in a model from values that are implied by its context of application. Finally, we conclude that for reaching an overlapping design consensus communication about properties of and values related to a model is required.

  10. Software sensors based on the grey-box modelling approach

    DEFF Research Database (Denmark)

    Carstensen, J.; Harremoës, P.; Strube, Rune

    1996-01-01

    In recent years the grey-box modelling approach has been applied to wastewater transportation and treatment Grey-box models are characterized by the combination of deterministic and stochastic terms to form a model where all the parameters are statistically identifiable from the on......-line measurements. With respect to the development of software sensors, the grey-box models possess two important features. Firstly, the on-line measurements can be filtered according to the grey-box model in order to remove noise deriving from the measuring equipment and controlling devices. Secondly, the grey-box...... models may contain terms which can be estimated on-line by use of the models and measurements. In this paper, it is demonstrated that many storage basins in sewer systems can be used as an on-line flow measurement provided that the basin is monitored on-line with a level transmitter and that a grey-box...

  11. The standard data model approach to patient record transfer.

    Science.gov (United States)

    Canfield, K; Silva, M; Petrucci, K

    1994-01-01

    This paper develops an approach to electronic data exchange of patient records from Ambulatory Encounter Systems (AESs). This approach assumes that the AES is based upon a standard data model. The data modeling standard used here is IDEFIX for Entity/Relationship (E/R) modeling. Each site that uses a relational database implementation of this standard data model (or a subset of it) can exchange very detailed patient data with other such sites using industry standard tools and without excessive programming efforts. This design is detailed below for a demonstration project between the research-oriented geriatric clinic at the Baltimore Veterans Affairs Medical Center (BVAMC) and the Laboratory for Healthcare Informatics (LHI) at the University of Maryland.

  12. Becoming and development of man: anthroposophistic approach.

    Directory of Open Access Journals (Sweden)

    Ionova E.N.

    2010-04-01

    Full Text Available Anthroposophistic orientated view of R.Shtayner to development of a man during all life is systematized. Anthroposophistic conception of development of a man is based on such substantive provisions: unity corporal-heartfelt-spiritual life; connection of component parts of psyche with physiological organization of man; an interconditionality of physiological, heartfelt and spiritual development is in the rhythm of seven years. It is rotined that a health, heartfelt rest and happiness, is the result of harmonic development. All three aspects are the legal certificates of constituents life of man.

  13. The cultural approach in the development discourse

    Directory of Open Access Journals (Sweden)

    MACIA MARTÍNEZ, Irene

    2013-11-01

    Full Text Available We will try to analyse scope of the theoretical reflections making emphasis in the cultural element within the development discourse. Our analysis is carried out through a short study of different branches of Sociology and Anthropology interpretative perspectives regarding the development concept. Focusing the attention on cultural diversity, we want to analyse the presence of this matter in development policies. In the first place, we have carried out researches about the suitability of some universal values and its cross-cultural potential. Secondly, we have analysed how pluralism has shaped the development discourse and the language used for International Cooperation

  14. Modeling Social Annotation: a Bayesian Approach

    CERN Document Server

    Plangprasopchok, Anon

    2008-01-01

    Collaborative tagging systems, such as del.icio.us, CiteULike, and others, allow users to annotate objects, e.g., Web pages or scientific papers, with descriptive labels called tags. The social annotations, contributed by thousands of users, can potentially be used to infer categorical knowledge, classify documents or recommend new relevant information. Traditional text inference methods do not make best use of socially-generated data, since they do not take into account variations in individual users' perspectives and vocabulary. In a previous work, we introduced a simple probabilistic model that takes interests of individual annotators into account in order to find hidden topics of annotated objects. Unfortunately, our proposed approach had a number of shortcomings, including overfitting, local maxima and the requirement to specify values for some parameters. In this paper we address these shortcomings in two ways. First, we extend the model to a fully Bayesian framework. Second, we describe an infinite ver...

  15. Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach.

    Science.gov (United States)

    Leino, O; Karjalainen, A K; Tuomisto, J T

    2013-04-01

    Fish contains both beneficial substances e.g. docosahexaenoic acids but also harmful compounds e.g. methylmercury. Importantly, the health effects caused by these two substances can be evaluated in one common end point, intelligence quotient (IQ), providing a more transparent analysis. We estimated health effects of maternal fish consumption on child's central nervous system by creating a model with three alternative maternal fish consumption scenarios (lean fish, fatty fish, and current fish consumption). Additionally, we analyzed impacts of both regular fish consumption and extreme fish consumption habits. At the individual level, the simulated net effects were small, encompassing a range of one IQ point in all scenarios. Fatty fish consumption, however, clearly generated a beneficial net IQ effect, and lean fish consumption evoked an adverse net IQ effect. In view of the current fish consumption pattern of Finnish mothers the benefits and risks seem to more or less compensate each other. This study clearly shows the significance of which fish species are consumed during pregnancy and lactation, and the results can be generalized to apply to typical western population fish consumption habits.

  16. CM5: A pre-Swarm magnetic field model based upon the comprehensive modeling approach

    DEFF Research Database (Denmark)

    Sabaka, T.; Olsen, Nils; Tyler, Robert

    2014-01-01

    We have developed a model based upon the very successful Comprehensive Modeling (CM) approach using recent CHAMP, Ørsted, SAC-C and observatory hourly-means data from September 2000 to the end of 2013. This CM, called CM5, was derived from the algorithm that will provide a consistent line of Level...

  17. How Qualitative Methods Can be Used to Inform Model Development.

    Science.gov (United States)

    Husbands, Samantha; Jowett, Susan; Barton, Pelham; Coast, Joanna

    2017-06-01

    Decision-analytic models play a key role in informing healthcare resource allocation decisions. However, there are ongoing concerns with the credibility of models. Modelling methods guidance can encourage good practice within model development, but its value is dependent on its ability to address the areas that modellers find most challenging. Further, it is important that modelling methods and related guidance are continually updated in light of any new approaches that could potentially enhance model credibility. The objective of this article was to highlight the ways in which qualitative methods have been used and recommended to inform decision-analytic model development and enhance modelling practices. With reference to the literature, the article discusses two key ways in which qualitative methods can be, and have been, applied. The first approach involves using qualitative methods to understand and inform general and future processes of model development, and the second, using qualitative techniques to directly inform the development of individual models. The literature suggests that qualitative methods can improve the validity and credibility of modelling processes by providing a means to understand existing modelling approaches that identifies where problems are occurring and further guidance is needed. It can also be applied within model development to facilitate the input of experts to structural development. We recommend that current and future model development would benefit from the greater integration of qualitative methods, specifically by studying 'real' modelling processes, and by developing recommendations around how qualitative methods can be adopted within everyday modelling practice.

  18. Development of the negative gravity anomaly of the 85°E Ridge, northeastern Indian Ocean – A process oriented modelling approach

    Indian Academy of Sciences (India)

    K M Sreejith; M Radhakrishna; K S Krishna; T J Majumdar

    2011-08-01

    The 85°E Ridge extends from the Mahanadi Basin, off northeastern margin of India to the Afanasy Nikitin Seamount in the Central Indian Basin. The ridge is associated with two contrasting gravity anomalies: negative anomaly over the north part (up to 5°N latitude), where the ridge structure is buried under thick Bengal Fan sediments and positive anomaly over the south part, where the structure is intermittently exposed above the seafloor. Ship-borne gravity and seismic reflection data are modelled using process oriented method and this suggest that the 85°E Ridge was emplaced on approximately 10–15 km thick elastic plate (Te) and in an off-ridge tectonic setting. We simulated gravity anomalies for different crust-sediment structural configurations of the ridge that were existing at three geological ages, such as Late Cretaceous, Early Miocene and Present. The study shows that the gravity anomaly of the ridge in the north has changed through time from its inception to present. During the Late Cretaceous the ridge was associated with a significant positive anomaly with a compensation generated by a broad flexure of the Moho boundary. By Early Miocene the ridge was approximately covered by the postcollision sediments and led to alteration of the initial gravity anomaly to a small positive anomaly. At present, the ridge is buried by approximately 3 km thick Bengal Fan sediments on its crestal region and about 8 km thick pre- and post-collision sediments on the flanks. This geological setting had changed physical properties of the sediments and led to alter the minor positive gravity anomaly of Early Miocene to the distinct negative gravity anomaly.

  19. Development of the negative gravity anomaly of the 85°E Ridge, northeastern Indian Ocean - A process oriented modelling approach

    Science.gov (United States)

    Sreejith, K. M.; Radhakrishna, M.; Krishna, K. S.; Majumdar, T. J.

    2011-08-01

    The 85°E Ridge extends from the Mahanadi Basin, off northeastern margin of India to the Afanasy Nikitin Seamount in the Central Indian Basin. The ridge is associated with two contrasting gravity anomalies: negative anomaly over the north part (up to 5°N latitude), where the ridge structure is buried under thick Bengal Fan sediments and positive anomaly over the south part, where the structure is intermittently exposed above the seafloor. Ship-borne gravity and seismic reflection data are modelled using process oriented method and this suggest that the 85°E Ridge was emplaced on approximately 10-15 km thick elastic plate ( Te) and in an off-ridge tectonic setting. We simulated gravity anomalies for different crust-sediment structural configurations of the ridge that were existing at three geological ages, such as Late Cretaceous, Early Miocene and Present. The study shows that the gravity anomaly of the ridge in the north has changed through time from its inception to present. During the Late Cretaceous the ridge was associated with a significant positive anomaly with a compensation generated by a broad flexure of the Moho boundary. By Early Miocene the ridge was approximately covered by the post-collision sediments and led to alteration of the initial gravity anomaly to a small positive anomaly. At present, the ridge is buried by approximately 3 km thick Bengal Fan sediments on its crestal region and about 8 km thick pre- and post-collision sediments on the flanks. This geological setting had changed physical properties of the sediments and led to alter the minor positive gravity anomaly of Early Miocene to the distinct negative gravity anomaly.

  20. Supervisor Development through Creative Approaches to Writing

    Science.gov (United States)

    Manathunga, Catherine; Peseta, Tai; McCormack, Coralie

    2010-01-01

    The development of research higher degree supervisors is a relatively recent phenomenon. In most cases, supervisor development continues within the traditional workshop mode and remains firmly located within what Bob Smith calls the "administrative framing" of supervision. This framing ensures that a liberal and policy-orientated discourse retains…

  1. Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.

    Science.gov (United States)

    Koch, Birgit; Buchholz, Mirko; Wermann, Michael; Heiser, Ulrich; Schilling, Stephan; Demuth, Hans-Ulrich

    2012-12-01

    Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamate-modified amyloid peptides deposited in neurodegenerative disorders such as Alzheimer's disease. Inhibitors of QC are currently in development as potential therapeutics. The crystal structures of the potent inhibitor PBD150 bound to human and murine QC (hQC, mQC) have been described recently. The binding modes of a dimethoxyphenyl moiety of the inhibitor are significantly different between the structures, which contrasts with a similar K(i) value. We show the conformation of PBD150 prone to disturbance by protein-protein interactions within the crystals. Semi-empirical calculations of the enzyme-inhibitor interaction within the crystal suggest significant differences in the dissociation constants between the binding modes. To probe for interactions in solution, a site-directed mutagenesis on hQC was performed. The replacement of F325 and I303 by alanine or asparagine resulted in a 800-fold lower activity of the inhibitor, whereas the exchange of S323 by alanine or valine led to a 20-fold higher activity of PBD150. The results provide an example of deciphering the interaction mode between a target enzyme and lead substance in solution, if co-crystallization does not mirror such interactions properly. Thus, the study might provide implications for rapid screening of binding modes also for other drug targets.

  2. An integrated approach to improving the parallel applications development process

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, Craig E [Los Alamos National Laboratory; Watson, Gregory R [IBM; Tibbitts, Beth R [IBM

    2009-01-01

    The development of parallel applications is becoming increasingly important to a broad range of industries. Traditionally, parallel programming was a niche area that was primarily exploited by scientists trying to model extremely complicated physical phenomenon. It is becoming increasingly clear, however, that continued hardware performance improvements through clock scaling and feature-size reduction are simply not going to be achievable for much longer. The hardware vendor's approach to addressing this issue is to employ parallelism through multi-processor and multi-core technologies. While there is little doubt that this approach produces scaling improvements, there are still many significant hurdles to be overcome before parallelism can be employed as a general replacement to more traditional programming techniques. The Parallel Tools Platform (PTP) Project was created in 2005 in an attempt to provide developers with new tools aimed at addressing some of the parallel development issues. Since then, the introduction of a new generation of peta-scale and multi-core systems has highlighted the need for such a platform. In this paper, we describe some of the challenges facing parallel application developers, present the current state of PTP, and provide a simple case study that demonstrates how PTP can be used to locate a potential deadlock situation in an MPI code.

  3. An integrated approach to improving the parallel applications development process

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, Craig E [Los Alamos National Laboratory; Watson, Gregory R [IBM; Tibbitts, Beth R [IBM

    2009-01-01

    The development of parallel applications is becoming increasingly important to a broad range of industries. Traditionally, parallel programming was a niche area that was primarily exploited by scientists trying to model extremely complicated physical phenomenon. It is becoming increasingly clear, however, that continued hardware performance improvements through clock scaling and feature-size reduction are simply not going to be achievable for much longer. The hardware vendor's approach to addressing this issue is to employ parallelism through multi-processor and multi-core technologies. While there is little doubt that this approach produces scaling improvements, there are still many significant hurdles to be overcome before parallelism can be employed as a general replacement to more traditional programming techniques. The Parallel Tools Platform (PTP) Project was created in 2005 in an attempt to provide developers with new tools aimed at addressing some of the parallel development issues. Since then, the introduction of a new generation of peta-scale and multi-core systems has highlighted the need for such a platform. In this paper, we describe some of the challenges facing parallel application developers, present the current state of PTP, and provide a simple case study that demonstrates how PTP can be used to locate a potential deadlock situation in an MPI code.

  4. A Generative Approach to the Development of Hidden-Figure Items.

    Science.gov (United States)

    Bejar, Issac I.; Yocom, Peter

    This report explores an approach to item development and psychometric modeling which explicitly incorporates knowledge about the mental models used by examinees in the solution of items into a psychometric model that characterize performances on a test, as well as incorporating that knowledge into the item development process. The paper focuses on…

  5. Stochastic approach to scientific development and innovations

    Energy Technology Data Exchange (ETDEWEB)

    Eto, H. (The University of Tokyo, Tokyo (Japan))

    1992-03-19

    Scientific development and technological innovations were studied by stochastic methods, in particular, scientometric method. The Bradford law was discussed which describes the behavior of scientific and engineering documents in the view point of their development and innovations. It was found that scientific development and innovations were governed more strongly by cumulative advantage effect and selfmultiplicative or self-reproductive effect than natural development and economic innovations. The elite characteristics were also pointed out by which a relatively small number of eminent scientific resources was selected in order to go ahead the others. These stochastic efforts could not fully explain peculiar characteristics of the Bradford law, and this inability probably indicated the essential gap between natural or economic science and bibliometrics. In addition, several attempts in stochastic theories and several possible trends of scientific activities in various scientific fields and in developing countries were discussed which might dissolve above gap. 23 refs., 8 figs., 24 tabs.

  6. Toward a More Holistic Evaluation Approach for Rural Development

    Science.gov (United States)

    Miyoshi, Koichi

    2013-01-01

    The discussion on and development of a holistic evaluation approach for rural development will be indispensable to improving and enriching the lives of rural people. This approach can be developed by considering the conceptualization of community policy structure in rural areas, the localization of policy structure in the rural community, and the…

  7. A Quantitative Model-Driven Comparison of Command Approaches in an Adversarial Process Model

    Science.gov (United States)

    2007-06-01

    12TH ICCRTS “Adapting C2 to the 21st Century” A Quantitative Model-Driven Comparison of Command Approaches in an Adversarial Process Model Tracks...Lenahan2 identified metrics and techniques for adversarial C2 process modeling . We intend to further that work by developing a set of adversarial process ...Approaches in an Adversarial Process Model 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK

  8. ON SOME APPROACHES TO ECONOMICMATHEMATICAL MODELING OF SMALL BUSINESS

    Directory of Open Access Journals (Sweden)

    Orlov A. I.

    2015-04-01

    Full Text Available Small business is an important part of modern Russian economy. We give a wide panorama developed by us of possible approaches to the construction of economic-mathematical models that may be useful to describe the dynamics of small businesses, as well as management. As for the description of certain problems of small business can use a variety of types of economic-mathematical and econometric models, we found it useful to consider a fairly wide range of such models, which resulted in quite a short description of the specific models. In this description of the models brought to such a level that an experienced professional in the field of economic-mathematical modeling could, if necessary, to develop their own specific model to the stage of design formulas and numerical results. Particular attention is paid to the use of statistical methods of non-numeric data, the most pressing at the moment. Are considered the problems of economic-mathematical modeling in solving problems of small business marketing. We have accumulated some experience in application of the methodology of economic-mathematical modeling in solving practical problems in small business marketing, in particular in the field of consumer goods and industrial purposes, educational services, as well as in the analysis and modeling of inflation, taxation and others. In marketing models of decision making theory we apply rankings and ratings. Is considered the problem of comparing averages. We present some models of the life cycle of small businesses - flow model projects, model of capture niches, and model of niche selection. We discuss the development of research on economic-mathematical modeling of small businesses

  9. Development of NASA's Models and Simulations Standard

    Science.gov (United States)

    Bertch, William J.; Zang, Thomas A.; Steele, Martin J.

    2008-01-01

    From the Space Shuttle Columbia Accident Investigation, there were several NASA-wide actions that were initiated. One of these actions was to develop a standard for development, documentation, and operation of Models and Simulations. Over the course of two-and-a-half years, a team of NASA engineers, representing nine of the ten NASA Centers developed a Models and Simulation Standard to address this action. The standard consists of two parts. The first is the traditional requirements section addressing programmatics, development, documentation, verification, validation, and the reporting of results from both the M&S analysis and the examination of compliance with this standard. The second part is a scale for evaluating the credibility of model and simulation results using levels of merit associated with 8 key factors. This paper provides an historical account of the challenges faced by and the processes used in this committee-based development effort. This account provides insights into how other agencies might approach similar developments. Furthermore, we discuss some specific applications of models and simulations used to assess the impact of this standard on future model and simulation activities.

  10. Teaching Web Evaluation: A Cognitive Development Approach

    Directory of Open Access Journals (Sweden)

    Candice Benjes-Small

    2013-08-01

    Full Text Available Web evaluation has been a standard information literacy offering for years and has always been a challenging topic for instruction librarians. Over time, the authors had tried a myriad of strategies to teach freshmen how to assess the credibility of Web sites but felt the efforts were insufficient. By familiarizing themselves with the cognitive development research, they were able to effectively revamp Web evaluation instruction to improve student learning. This article discusses the problems of traditional methods, such as checklists; summarizes the cognitive development research, particularly in regards to its relationship to the ACRL Information Literacy Standards; and details the instructional lesson plan developed by the authors that incorporates cognitive development theories.

  11. An action research approach to curriculum development

    Directory of Open Access Journals (Sweden)

    Phil Riding

    1995-01-01

    Full Text Available Action research has been used in many areas where an understanding of complex social situations has been sought in order to improve the quality of life. Among these are industrial, health and community work settings. Kurt Lewin, often cited as the originator of action research, used the methodology in his work with people affected by post- war social problems. Action research approaches to educational research were adopted in the late 60s and early 70s by the ‘teacher- researcher’ movement in the secondary education sector. This sought to bring the practising classroom teacher into the research process as the most effective person to identify problems and to find solutions.We believe that an action research approach can contribute very positively to activity within the tertiary sector concerned with teaching quality issues, and with national Teaching Quality Assessment initiatives. As 'reflective practitioners', we can achieve greater ownership of the evaluative process by becoming systematically self-assessing, alongside, and feeding into, external assessment processes.

  12. Exploration Systems Development (ESD) Approach to Enterprise Risk Management

    Science.gov (United States)

    Bauder, Stephen P.

    2014-01-01

    The National Aeronautics and Space Administration (NASA) Exploration Systems Development (ESD) Division has implemented an innovative approach to Enterprise Risk Management under a unique governance structure and streamlined integration model. ESD's mission is to design and build the capability to extend human existence to deep space. The Enterprise consists of three Programs: Space Launch System (SLS), Orion, and Ground Systems Development and Operations (GSDO). The SLS is a rocket and launch system that will be capable of powering humans, habitats, and support systems to deep space. Orion will be the first spacecraft in history capable of taking humans to multiple destinations within deep space. GSDO is modernizing Kennedy's spaceport to launch spacecraft built and designed by both NASA and private industry. ESD's approach to Enterprise Risk Management is commensurate with affordability and a streamlined management philosophy. ESD Enterprise Risk Management leverages off of the primary mechanisms for integration within the Enterprise. The Enterprise integration approach emphasizes delegation of authority to manage and execute the majority of cross-program activities and products to the individual Programs, while maintaining the overall responsibility for all cross-program activities at the Division. The intent of the ESD Enterprise Risk Management approach is to improve risk communication, to avoid replication and/or contradictory strategies, and to minimize overhead process burden. This is accomplished by the facilitation and integration of risk information within ESD. The ESD Division risks, Orion risks, SLS risks, and GSDO risks are owned and managed by the applicable Program. When the Programs have shared risks with multiple consequences, they are jointly owned and managed. When a risk is associated with the integrated system that involves more than one Program in condition, consequence, or mitigation plan, it is considered an Exploration Systems Integration

  13. OSPREY Model Development Status Update

    Energy Technology Data Exchange (ETDEWEB)

    Veronica J Rutledge

    2014-04-01

    During the processing of used nuclear fuel, volatile radionuclides will be discharged to the atmosphere if no recovery processes are in place to limit their release. The volatile radionuclides of concern are 3H, 14C, 85Kr, and 129I. Methods are being developed, via adsorption and absorption unit operations, to capture these radionuclides. It is necessary to model these unit operations to aid in the evaluation of technologies and in the future development of an advanced used nuclear fuel processing plant. A collaboration between Fuel Cycle Research and Development Offgas Sigma Team member INL and a NEUP grant including ORNL, Syracuse University, and Georgia Institute of Technology has been formed to develop off gas models and support off gas research. Georgia Institute of Technology is developing fundamental level model to describe the equilibrium and kinetics of the adsorption process, which are to be integrated with OSPREY. This report discusses the progress made on expanding OSPREY to be multiple component and the integration of macroscale and microscale level models. Also included in this report is a brief OSPREY user guide.

  14. A semiparametric approach to physiological flow models.

    Science.gov (United States)

    Verotta, D; Sheiner, L B; Ebling, W F; Stanski, D R

    1989-08-01

    By regarding sampled tissues in a physiological model as linear subsystems, the usual advantages of flow models are preserved while mitigating two of their disadvantages, (i) the need for assumptions regarding intratissue kinetics, and (ii) the need to simultaneously fit data from several tissues. To apply the linear systems approach, both arterial blood and (interesting) tissue drug concentrations must be measured. The body is modeled as having an arterial compartment (A) distributing drug to different linear subsystems (tissues), connected in a specific way by blood flow. The response (CA, with dimensions of concentration) of A is measured. Tissues receive input from A (and optionally from other tissues), and send output to the outside or to other parts of the body. The response (CT, total amount of drug in the tissue (T) divided by the volume of T) from the T-th one, for example, of such tissues is also observed. From linear systems theory, CT can be expressed as the convolution of CA with a disposition function, F(t) (with dimensions 1/time). The function F(t) depends on the (unknown) structure of T, but has certain other constant properties: The integral integral infinity0 F(t) dt is the steady state ratio of CT to CA, and the point F(0) is the clearance rate of drug from A to T divided by the volume of T. A formula for the clearance rate of drug from T to outside T can be derived. To estimate F(t) empirically, and thus mitigate disadvantage (i), we suggest that, first, a nonparametric (or parametric) function be fitted to CA data yielding predicted values, CA, and, second, the convolution integral of CA with F(t) be fitted to CT data using a deconvolution method. By so doing, each tissue's data are analyzed separately, thus mitigating disadvantage (ii). A method for system simulation is also proposed. The results of applying the approach to simulated data and to real thiopental data are reported.

  15. Building Energy Modeling: A Data-Driven Approach

    Science.gov (United States)

    Cui, Can

    Buildings consume nearly 50% of the total energy in the United States, which drives the need to develop high-fidelity models for building energy systems. Extensive methods and techniques have been developed, studied, and applied to building energy simulation and forecasting, while most of work have focused on developing dedicated modeling approach for generic buildings. In this study, an integrated computationally efficient and high-fidelity building energy modeling framework is proposed, with the concentration on developing a generalized modeling approach for various types of buildings. First, a number of data-driven simulation models are reviewed and assessed on various types of computationally expensive simulation problems. Motivated by the conclusion that no model outperforms others if amortized over diverse problems, a meta-learning based recommendation system for data-driven simulation modeling is proposed. To test the feasibility of the proposed framework on the building energy system, an extended application of the recommendation system for short-term building energy forecasting is deployed on various buildings. Finally, Kalman filter-based data fusion technique is incorporated into the building recommendation system for on-line energy forecasting. Data fusion enables model calibration to update the state estimation in real-time, which filters out the noise and renders more accurate energy forecast. The framework is composed of two modules: off-line model recommendation module and on-line model calibration module. Specifically, the off-line model recommendation module includes 6 widely used data-driven simulation models, which are ranked by meta-learning recommendation system for off-line energy modeling on a given building scenario. Only a selective set of building physical and operational characteristic features is needed to complete the recommendation task. The on-line calibration module effectively addresses system uncertainties, where data fusion on

  16. Developing Friction Stir Welding Process Model for ICME Application

    Science.gov (United States)

    Yang, Yu-Ping

    2015-01-01

    A framework for developing a product involving manufacturing processes was developed with integrated computational materials engineering approach. The key component in the framework is a process modeling tool which includes a thermal model, a microstructure model, a thermo-mechanical, and a property model. Using friction stir welding (FSW) process as an example, development of the process modeling tool was introduced in detail. The thermal model and the microstructure model of FSW of steels were validated with the experiment data. The model can predict reasonable temperature and hardness distributions as observed in the experiment. The model was applied to predict residual stress and joint strength of a pipe girth weld.

  17. VARTM Model Development and Verification

    Science.gov (United States)

    Cano, Roberto J. (Technical Monitor); Dowling, Norman E.

    2004-01-01

    In this investigation, a comprehensive Vacuum Assisted Resin Transfer Molding (VARTM) process simulation model was developed and verified. The model incorporates resin flow through the preform, compaction and relaxation of the preform, and viscosity and cure kinetics of the resin. The computer model can be used to analyze the resin flow details, track the thickness change of the preform, predict the total infiltration time and final fiber volume fraction of the parts, and determine whether the resin could completely infiltrate and uniformly wet out the preform.

  18. Data mining approach to model the diagnostic service management.

    Science.gov (United States)

    Lee, Sun-Mi; Lee, Ae-Kyung; Park, Il-Su

    2006-01-01

    Korea has National Health Insurance Program operated by the government-owned National Health Insurance Corporation, and diagnostic services are provided every two year for the insured and their family members. Developing a customer relationship management (CRM) system using data mining technology would be useful to improve the performance of diagnostic service programs. Under these circumstances, this study developed a model for diagnostic service management taking into account the characteristics of subjects using a data mining approach. This study could be further used to develop an automated CRM system contributing to the increase in the rate of receiving diagnostic services.

  19. A Systems Engineering Approach to Architecture Development

    Science.gov (United States)

    Di Pietro, David A.

    2015-01-01

    Architecture development is often conducted prior to system concept design when there is a need to determine the best-value mix of systems that works collectively in specific scenarios and time frames to accomplish a set of mission area objectives. While multiple architecture frameworks exist, they often require use of unique taxonomies and data structures. In contrast, this paper characterizes architecture development using terminology widely understood within the systems engineering community. Using a notional civil space architecture example, it employs a multi-tier framework to describe the enterprise level architecture and illustrates how results of lower tier, mission area architectures integrate into the enterprise architecture. It also presents practices for conducting effective mission area architecture studies, including establishing the trade space, developing functions and metrics, evaluating the ability of potential design solutions to meet the required functions, and expediting study execution through the use of iterative design cycles

  20. New Approach to Develop a Bilingual Compiler

    Directory of Open Access Journals (Sweden)

    Shampa Banik

    2014-02-01

    Full Text Available This research work presents a development of a Bangla programming language along with its compiler with an aim to introduce the programming language to the beginner through mother tongue. The syntax and construction of the programming language has been kept similar to BASIC language by considering the fact that BASIC is very easier in terms of its syntax, which is reasonably applicable as an introductory language for new programmer. A compiler has been developed for the proposed programming language that compile the source code into an intermediate code which is optimized. We have developed our system in Java. Our software is an efficient translation engine which can translate English source code to Bangla source code. We have implemented the system with a lot of test cases to identify what aspects of the system best explain their relative performance.

  1. MULTI MODEL DATA MINING APPROACH FOR HEART FAILURE PREDICTION

    Directory of Open Access Journals (Sweden)

    Priyanka H U

    2016-09-01

    Full Text Available Developing predictive modelling solutions for risk estimation is extremely challenging in health-care informatics. Risk estimation involves integration of heterogeneous clinical sources having different representation from different health-care provider making the task increasingly complex. Such sources are typically voluminous, diverse, and significantly change over the time. Therefore, distributed and parallel computing tools collectively termed big data tools are in need which can synthesize and assist the physician to make right clinical decisions. In this work we propose multi-model predictive architecture, a novel approach for combining the predictive ability of multiple models for better prediction accuracy. We demonstrate the effectiveness and efficiency of the proposed work on data from Framingham Heart study. Results show that the proposed multi-model predictive architecture is able to provide better accuracy than best model approach. By modelling the error of predictive models we are able to choose sub set of models which yields accurate results. More information was modelled into system by multi-level mining which has resulted in enhanced predictive accuracy.

  2. Development of a simplified biofilm model

    Science.gov (United States)

    Sarkar, Sushovan; Mazumder, Debabrata

    2017-07-01

    A simplified approach for analyzing the biofilm process in deriving an easy model has been presented. This simplified biofilm model formulated correlations between substrate concentration in the influent/effluent and at biofilm-liquid interface along with substrate flux and biofilm thickness. The model essentially considered the external mass transport according to Fick's Law, steady state substrate as well as biomass balance for attached growth microorganisms. In substrate utilization, Monod growth kinetics has been followed incorporating relevant boundary conditions at the liquid-biofilm interface and at the attachment surface. The numerical solution of equations was accomplished using Runge-Kutta method and accordingly an integrated computer program was developed. The model has been successfully applied in a distinct set of trials with varying range of representative input variables. The model performance was compared with available existing methods and it was found an easy, accurate method that can be used for process design of biofilm reactor.

  3. A modular approach to addressing model design, scale, and parameter estimation issues in distributed hydrological modelling

    Science.gov (United States)

    Leavesley, G.H.; Markstrom, S.L.; Restrepo, Pedro J.; Viger, R.J.

    2002-01-01

    A modular approach to model design and construction provides a flexible framework in which to focus the multidisciplinary research and operational efforts needed to facilitate the development, selection, and application of the most robust distributed modelling methods. A variety of modular approaches have been developed, but with little consideration for compatibility among systems and concepts. Several systems are proprietary, limiting any user interaction. The US Geological Survey modular modelling system (MMS) is a modular modelling framework that uses an open source software approach to enable all members of the scientific community to address collaboratively the many complex issues associated with the design, development, and application of distributed hydrological and environmental models. Implementation of a common modular concept is not a trivial task. However, it brings the resources of a larger community to bear on the problems of distributed modelling, provides a framework in which to compare alternative modelling approaches objectively, and provides a means of sharing the latest modelling advances. The concepts and components of the MMS are described and an example application of the MMS, in a decision-support system context, is presented to demonstrate current system capabilities. Copyright ?? 2002 John Wiley and Sons, Ltd.

  4. Chemometrics approach to substrate development, case: semisyntetic cheese

    DEFF Research Database (Denmark)

    Nielsen, Per Væggemose; Hansen, Birgitte Vedel

    1998-01-01

    from food production facilities.The Chemometrics approach to substrate development is illustrated by the development of a semisyntetic cheese substrate. Growth, colour formation and mycotoxin production of 6 cheese related fungi were studied on 9 types of natural cheeses and 24 synthetic cheese......, the most frequently occurring contaminant on semi-hard cheese. Growth experiments on the substrate were repeatable and reproducible. The substrate was also suitable for the starter P. camemberti. Mineral elements in cheese were shown to have strong effect on growth, mycotoxin production and colour...... formation of fungi. For P. roqueforti, P. discolor, P. verrucosum and Aspergillus versicolor the substrate was less suitable as a model cheese substrate, which indicates great variation in nutritional demands of the fungi. Substrates suitable for studies of specific cheese types was found for P. roqueforti...

  5. Revising Amartya Sen's Capability Approach to Education for Ethical Development

    Science.gov (United States)

    Mok, Kwangsu; Jeong, Wongyu

    2016-01-01

    The purpose of this paper is to examine whether Amartya Sen's capability approach can suggest an appropriate theory of education for ethical development. Many advocates of Sen's capability approach insist that his approach is superior to rival theories of education, including the human capital theory. This is because Sen emphasizes the purpose and…

  6. Evaluating face trustworthiness: a model based approach.

    Science.gov (United States)

    Todorov, Alexander; Baron, Sean G; Oosterhof, Nikolaas N

    2008-06-01

    Judgments of trustworthiness from faces determine basic approach/avoidance responses and approximate the valence evaluation of faces that runs across multiple person judgments. Here, based on trustworthiness judgments and using a computer model for face representation, we built a model for representing face trustworthiness (study 1). Using this model, we generated novel faces with an increased range of trustworthiness and used these faces as stimuli in a functional Magnetic Resonance Imaging study (study 2). Although participants did not engage in explicit evaluation of the faces, the amygdala response changed as a function of face trustworthiness. An area in the right amygdala showed a negative linear response-as the untrustworthiness of faces increased so did the amygdala response. Areas in the left and right putamen, the latter area extended into the anterior insula, showed a similar negative linear response. The response in the left amygdala was quadratic--strongest for faces on both extremes of the trustworthiness dimension. The medial prefrontal cortex and precuneus also showed a quadratic response, but their response was strongest to faces in the middle range of the trustworthiness dimension.

  7. A consortium approach to glass furnace modeling.

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S.-L.; Golchert, B.; Petrick, M.

    1999-04-20

    Using computational fluid dynamics to model a glass furnace is a difficult task for any one glass company, laboratory, or university to accomplish. The task of building a computational model of the furnace requires knowledge and experience in modeling two dissimilar regimes (the combustion space and the liquid glass bath), along with the skill necessary to couple these two regimes. Also, a detailed set of experimental data is needed in order to evaluate the output of the code to ensure that the code is providing proper results. Since all these diverse skills are not present in any one research institution, a consortium was formed between Argonne National Laboratory, Purdue University, Mississippi State University, and five glass companies in order to marshal these skills into one three-year program. The objective of this program is to develop a fully coupled, validated simulation of a glass melting furnace that may be used by industry to optimize the performance of existing furnaces.

  8. Child Development: An Active Learning Approach

    Science.gov (United States)

    Levine, Laura E.; Munsch, Joyce

    2010-01-01

    Within each chapter of this innovative topical text, the authors engage students by demonstrating the wide range of real-world applications of psychological research connected to child development. In particular, the distinctive Active Learning features incorporated throughout the book foster a dynamic and personal learning process for students.…

  9. Personality Development in Infancy; A Biological Approach.

    Science.gov (United States)

    Freedman, D. G.

    This comprehensive paper proposing the use of evolutionary theory as a basis for studies in developmental psychology includes these specific sections: (1) Developmental Theories--a brief overview, (2) Individual Differences, (3) Culture and Inbreeding, (4) Sexual Dimorphism, (5) Critical Periods in the Development of Attachments, (6) Continuity…

  10. Towards a Provotyping Approach in Systems Development

    DEFF Research Database (Denmark)

    Mogensen, Preben Holst

    1992-01-01

    concrete experience is developed through an investigation of prototyping and activity theory. Exploration of this notion leads to the idea of the systemdeveloper ‘provoking ’ concrete, everyday practice, by exposing current problems, calling forth what usually is taken for granted. Problems with current...

  11. An approach towards sustainable groundwater development

    African Journals Online (AJOL)

    ... Theory is based on the presupposition that an individual's behaviour, environmen- ... Any water-conservation campaign developed using this theory would contain 4 main ... the date and time on which contact was made, the purpose of contact, as well as ..... intervention is meticulously planned using well practised socio-.

  12. A bioinformatics approach to marker development

    NARCIS (Netherlands)

    Tang, J.

    2008-01-01

    The thesis focuses on two bioinformatics research topics: the development of tools for an efficient and reliable identification of single nucleotides polymorphisms (SNPs) and polymorphic simple sequence repeats (SSRs) from expressed sequence tags (ESTs) (Chapter 2, 3 and 4), and the subsequent imple

  13. Teacher Professional Development Approach:Action Research

    Institute of Scientific and Technical Information of China (English)

    LIU Yang

    2013-01-01

    Theory and practice, researchers and practitioners are usually isolated in traditional education research, so much so that the research results can not solve the problems that teachers encounter in their teaching practice. As a new mode, action research provides a bridge linking theory and teaching practice as well as a way to promote teacher development.

  14. A constructivist approach to artifact development

    DEFF Research Database (Denmark)

    Skytte, Hans

    2008-01-01

    . The main result of the study shows that the concepts used (identity, image, organizational field etc.) to analyze the companies construct of the concepts, are linked in recursive patterns. This means that a company's artifact development takes place in recursive patterns consisting of concepts, meanings...

  15. Classical and Contemporary Approaches for Moral Development

    Science.gov (United States)

    Cam, Zekeriya; Seydoogullari, Sedef; Cavdar, Duygu; Cok, Figen

    2012-01-01

    Most of the information in the moral development literature depends on Theories of Piaget and Kohlberg. The theoretical contribution by Gilligan and Turiel are not widely known and not much resource is available in Turkish. For this reason introducing and discussing the theories of Gilligan and Turiel and more comprehensive perspective for moral…

  16. Child Development: An Active Learning Approach

    Science.gov (United States)

    Levine, Laura E.; Munsch, Joyce

    2010-01-01

    Within each chapter of this innovative topical text, the authors engage students by demonstrating the wide range of real-world applications of psychological research connected to child development. In particular, the distinctive Active Learning features incorporated throughout the book foster a dynamic and personal learning process for students.…

  17. Integrative Educational Approach Oriented Towards Software and System Development

    Directory of Open Access Journals (Sweden)

    Anca Juliana Stoica

    2013-01-01

    Full Text Available The paper is based on our academic teaching and research work in software and system engineering to effectively develop modern, complex real-life Web application systems. It bridges the gap between academic education and industry needs and illustrates how such collaboration can be successfully developed in the IT area where technology development is rapid. Its scope covers the processes, models, technologies, people, and knowledge that have the capability to contribute to developing such systems. The paper also relates to contributions of some of Harlan D. Mills award recipients for software engineering achievement, to address the needs to: i improve the engineering education in an academic setting, and ii develop real-life software and system projects. Hybrid educational methods are applied for student learning that combine class room approach of teaching fundamental theoretical concepts and practice via real world complex projects embedding intelligence in software and systems products. System thinking demanded by modern design philosophies is applied to interlink prod-ucts, software, and people. Student groups are developing their projects in an interactive and collaborative manner.

  18. On a Markovian approach for modeling passive solar devices

    Energy Technology Data Exchange (ETDEWEB)

    Bottazzi, F.; Liebling, T.M. (Chaire de Recherche Operationelle, Ecole Polytechnique Federale de Lausanne (Switzerland)); Scartezzini, J.L.; Nygaard-Ferguson, M. (Lab. d' Energie Solaire et de Physique du Batiment, Ecole Polytechnique Federale de Lausanne (Switzerland))

    1991-01-01

    Stochastic models for the analysis of the energy and thermal comfort performances of passive solar devices have been increasingly studied for over a decade. A new approach to thermal building modeling, based on Markov chains, is proposed here to combine both the accuracy of traditional dynamic simulation with the practical advantages of simplified methods. A main difficulty of the Markovian approach is the discretization of the system variables. Efficient procedures have been developed to carry out this discretization and several numerical experiments have been performed to analyze the possibilities and limitations of the Markovian model. Despite its restrictive assumptions, it will be shown that accurate results are indeed obtained by this method. However, due to discretization, computer memory reqirements are more than inversely proportional to accuracy. (orig.).

  19. Motorola Secure Software Development Model

    Directory of Open Access Journals (Sweden)

    Francis Mahendran

    2008-08-01

    Full Text Available In today's world, the key to meeting the demand for improved security is to implement repeatable processes that reliably deliver measurably improved security. While many organizations have announced efforts to institutionalize a secure software development process, there is little or no industry acceptance for a common process improvement framework for secure software development. Motorola has taken the initiative to develop such a framework, and plans to share this with the Software Engineering Institute for possible inclusion into its Capability Maturity Model Integration (CMMI®. This paper will go into the details of how Motorola is addressing this issue. The model that is being developed is designed as an extension of the existing CMMI structure. The assumption is that the audience will have a basic understanding of the SEI CMM® / CMMI® process framework. The paper will not describe implementation details of a security process model or improvement framework, but will address WHAT security practices are required for a company with many organizations operating at different maturity levels. It is left to the implementing organization to answer the HOW, WHEN, WHO and WHERE aspects. The paper will discuss how the model is being implemented in the Motorola Software Group.

  20. An interdisciplinary approach for earthquake modelling and forecasting

    Science.gov (United States)

    Han, P.; Zhuang, J.; Hattori, K.; Ogata, Y.

    2016-12-01

    Earthquake is one of the most serious disasters, which may cause heavy casualties and economic losses. Especially in the past two decades, huge/mega earthquakes have hit many countries. Effective earthquake forecasting (including time, location, and magnitude) becomes extremely important and urgent. To date, various heuristically derived algorithms have been developed for forecasting earthquakes. Generally, they can be classified into two types: catalog-based approaches and non-catalog-based approaches. Thanks to the rapid development of statistical seismology in the past 30 years, now we are able to evaluate the performances of these earthquake forecast approaches quantitatively. Although a certain amount of precursory information is available in both earthquake catalogs and non-catalog observations, the earthquake forecast is still far from satisfactory. In most case, the precursory phenomena were studied individually. An earthquake model that combines self-exciting and mutually exciting elements was developed by Ogata and Utsu from the Hawkes process. The core idea of this combined model is that the status of the event at present is controlled by the event itself (self-exciting) and all the external factors (mutually exciting) in the past. In essence, the conditional intensity function is a time-varying Poisson process with rate λ(t), which is composed of the background rate, the self-exciting term (the information from past seismic events), and the external excitation term (the information from past non-seismic observations). This model shows us a way to integrate the catalog-based forecast and non-catalog-based forecast. Against this background, we are trying to develop a new earthquake forecast model which combines catalog-based and non-catalog-based approaches.