WorldWideScience

Sample records for model studies presented

  1. Lithium-Ion Battery Safety Study Using Multi-Physics Internal Short-Circuit Model (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Kim, G-.H.; Smith, K.; Pesaran, A.

    2009-06-01

    This presentation outlines NREL's multi-physics simulation study to characterize an internal short by linking and integrating electrochemical cell, electro-thermal, and abuse reaction kinetics models.

  2. A model study of present-day Hall-effect circulators

    International Nuclear Information System (INIS)

    Placke, B.; Bosco, S.; DiVincenzo, D.P.

    2017-01-01

    Stimulated by the recent implementation of a three-port Hall-effect microwave circulator of Mahoney et al. (MEA), we present model studies of the performance of this device. Our calculations are based on the capacitive-coupling model of Viola and DiVincenzo (VD). Based on conductance data from a typical Hall-bar device obtained from a two-dimensional electron gas (2DEG) in a magnetic field, we numerically solve the coupled field-circuit equations to calculate the expected performance of the circulator, as determined by the S parameters of the device when coupled to 50Ω ports, as a function of frequency and magnetic field. Above magnetic fields of 1.5 T, for which a typical 2DEG enters the quantum Hall regime (corresponding to a Landau-level filling fraction ν of 20), the Hall angle θ_H = tan"-"1 σ_x_y/σ_x_x always remains close to 90 , and the S parameters are close to the analytic predictions of VD for θ_H = π/2. As anticipated by VD, MEA find the device to have rather high (kΩ) impedance, and thus to be extremely mismatched to 50Ω, requiring the use of impedance matching. We incorporate the lumped matching circuits of MEA in our modeling and confirm that they can produce excellent circulation, although confined to a very small bandwidth. We predict that this bandwidth is significantly improved by working at lower magnetic field when the Landau index is high, e.g. ν = 20, and the impedance mismatch is correspondingly less extreme. Our modeling also confirms the observation of MEA that parasitic port-to-port capacitance can produce very interesting countercirculation effects. (orig.)

  3. A model study of present-day Hall-effect circulators

    Energy Technology Data Exchange (ETDEWEB)

    Placke, B. [RWTH Aachen University, Institute for Quantum Information, Aachen (Germany); Bosco, S. [RWTH Aachen University, Institute for Quantum Information, Aachen (Germany); Juelich-Aachen Research Alliance (JARA), Fundamentals of Future Information Technologiesh, Juelich (Germany); DiVincenzo, D.P. [RWTH Aachen University, Institute for Quantum Information, Aachen (Germany); Juelich-Aachen Research Alliance (JARA), Fundamentals of Future Information Technologiesh, Juelich (Germany); Peter Gruenberg Institute, Theoretical Nanoelectronics, Forschungszentrum Juelich, Juelich (Germany)

    2017-12-15

    Stimulated by the recent implementation of a three-port Hall-effect microwave circulator of Mahoney et al. (MEA), we present model studies of the performance of this device. Our calculations are based on the capacitive-coupling model of Viola and DiVincenzo (VD). Based on conductance data from a typical Hall-bar device obtained from a two-dimensional electron gas (2DEG) in a magnetic field, we numerically solve the coupled field-circuit equations to calculate the expected performance of the circulator, as determined by the S parameters of the device when coupled to 50Ω ports, as a function of frequency and magnetic field. Above magnetic fields of 1.5 T, for which a typical 2DEG enters the quantum Hall regime (corresponding to a Landau-level filling fraction ν of 20), the Hall angle θ{sub H} = tan{sup -1} σ{sub xy}/σ{sub xx} always remains close to 90 , and the S parameters are close to the analytic predictions of VD for θ{sub H} = π/2. As anticipated by VD, MEA find the device to have rather high (kΩ) impedance, and thus to be extremely mismatched to 50Ω, requiring the use of impedance matching. We incorporate the lumped matching circuits of MEA in our modeling and confirm that they can produce excellent circulation, although confined to a very small bandwidth. We predict that this bandwidth is significantly improved by working at lower magnetic field when the Landau index is high, e.g. ν = 20, and the impedance mismatch is correspondingly less extreme. Our modeling also confirms the observation of MEA that parasitic port-to-port capacitance can produce very interesting countercirculation effects. (orig.)

  4. Methodology for geometric modelling. Presentation and administration of site descriptive models; Metodik foer geometrisk modellering. Presentation och administration av platsbeskrivande modeller

    Energy Technology Data Exchange (ETDEWEB)

    Munier, Raymond [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Hermanson, Jan [Golder Associates (Sweden)

    2001-03-01

    This report presents a methodology to construct, visualise and present geoscientific descriptive models based on data from the site investigations, which the SKB currently performs, to build an underground nuclear waste disposal facility in Sweden. It is designed for interaction with SICADA (SKB:s site characterisation database) and RVS (SKB:s Rock Visualisation System). However, the concepts of the methodology are general and can be used with other tools capable of handling 3D geometries and parameters. The descriptive model is intended to be an instrument where site investigation data from all disciplines are put together to form a comprehensive visual interpretation of the studied rock mass. The methodology has four main components: 1. Construction of a geometrical model of the interpreted main structures at the site. 2. Description of the geoscientific characteristics of the structures. 3. Description and geometrical implementation of the geometric uncertainties in the interpreted model structures. 4. Quality system for the handling of the geometrical model, its associated database and some aspects of the technical auditing. The geometrical model forms a basis for understanding the main elements and structures of the investigated site. Once the interpreted geometries are in place in the model, the system allows for adding descriptive and quantitative data to each modelled object through a system of intuitive menus. The associated database allows each geometrical object a complete quantitative description of all geoscientific disciplines, variabilities, uncertainties in interpretation and full version history. The complete geometrical model and its associated database of object descriptions are to be recorded in a central quality system. Official, new and old versions of the model are administered centrally in order to have complete quality assurance of each step in the interpretation process. The descriptive model is a cornerstone in the understanding of the

  5. ISOCT study of collagen crosslinking of collagen in cancer models (Conference Presentation)

    Science.gov (United States)

    Spicer, Graham; Young, Scott T.; Yi, Ji; Shea, Lonnie D.; Backman, Vadim

    2016-03-01

    The role of extracellular matrix modification and signaling in cancer progression is an increasingly recognized avenue for the progression of the disease. Previous study of field effect carcinogenesis with Inverse Spectroscopic Optical Coherence Tomography (ISOCT) has revealed pronounced changes in the nanoscale-sensitive mass fractal dimension D measured from field effect tissue when compared to healthy tissue. However, the origin of this difference in tissue ultrastructure in field effect carcinogenesis has remained poorly understood. Here, we present findings supporting the idea that enzymatic crosslinking of the extracellular matrix is an effect that presents at the earliest stages of carcinogenesis. We use a model of collagen gel with crosslinking induced by lysyl oxidase (LOXL4) to recapitulate the difference in D previously reported from healthy and cancerous tissue biopsies. Furthermore, STORM imaging of this collagen gel model verifies the morphologic effects of enzymatic crosslinking at length scales as small as 40 nm, close to the previously reported lower length scale sensitivity threshold of 35 nm for ISOCT. Analysis of the autocorrelation function from STORM images of collagen gels and subsequent fitting to the Whittle-Matérn correlation function shows a similar effect of LOXL4 on D from collagen measured with ISOCT and STORM. We extend this to mass spectrometric study of tissue to directly measure concentrations of collagen crosslink residues. The validation of ISOCT as a viable tool for non-invasive rapid quantification of collagen ultrastructure lends it to study other physiological phenomena involving ECM restructuring such as atherosclerotic plaque screening or cervical ripening during pregnancy.

  6. Presenting an evaluation model of the trauma registry software.

    Science.gov (United States)

    Asadi, Farkhondeh; Paydar, Somayeh

    2018-04-01

    Trauma is a major cause of 10% death in the worldwide and is considered as a global concern. This problem has made healthcare policy makers and managers to adopt a basic strategy in this context. Trauma registry has an important and basic role in decreasing the mortality and the disabilities due to injuries resulted from trauma. Today, different software are designed for trauma registry. Evaluation of this software improves management, increases efficiency and effectiveness of these systems. Therefore, the aim of this study is to present an evaluation model for trauma registry software. The present study is an applied research. In this study, general and specific criteria of trauma registry software were identified by reviewing literature including books, articles, scientific documents, valid websites and related software in this domain. According to general and specific criteria and related software, a model for evaluating trauma registry software was proposed. Based on the proposed model, a checklist designed and its validity and reliability evaluated. Mentioned model by using of the Delphi technique presented to 12 experts and specialists. To analyze the results, an agreed coefficient of %75 was determined in order to apply changes. Finally, when the model was approved by the experts and professionals, the final version of the evaluation model for the trauma registry software was presented. For evaluating of criteria of trauma registry software, two groups were presented: 1- General criteria, 2- Specific criteria. General criteria of trauma registry software were classified into four main categories including: 1- usability, 2- security, 3- maintainability, and 4-interoperability. Specific criteria were divided into four main categories including: 1- data submission and entry, 2- reporting, 3- quality control, 4- decision and research support. The presented model in this research has introduced important general and specific criteria of trauma registry software

  7. Making sense to modelers: Presenting UML class model differences in prose

    DEFF Research Database (Denmark)

    Störrle, Harald

    2013-01-01

    Understanding the difference between two models, such as different versions of a design, can be difficult. It is a commonly held belief in the model differencing community that the best way of presenting a model difference is by using graph or tree-based visualizations. We disagree and present an...... by a controlled experiment that tests three alternatives to presenting model differences. Our findings support our claim that the approach presented here is superior to EMF Compare.......Understanding the difference between two models, such as different versions of a design, can be difficult. It is a commonly held belief in the model differencing community that the best way of presenting a model difference is by using graph or tree-based visualizations. We disagree and present...... an alternative approach where sets of low-level model differences are abstracted into high-level model differences that lend themselves to being presented textually. This format is informed by an explorative survey to elicit the change descriptions modelers use themselves. Our approach is validated...

  8. Explanatory models and distress in primary caregivers of patients with acute psychotic presentations: A study from South India.

    Science.gov (United States)

    Joy, Deepa S; Manoranjitham, S D; Samuel, P; Jacob, K S

    2017-11-01

    Emotional distress among caregivers of people with mental illness is common, changes overtime and requires appropriate coping strategies to prevent long-term disability. Explanatory models, which underpin understanding of disease and illness, are crucial to coping. To study the association of explanatory models and distress among caregivers of people with acute psychotic illness. A total of 60 consecutive patients and their primary caregivers who presented to the Department of Psychiatry, Christian Medical College, Vellore, were recruited for the study. Positive and Negative Syndrome Scale (PANSS), Short Explanatory Model Interview (SEMI) and the General Health Questionnaire-12 (GHQ-12) were used to assess severity of psychosis, explanatory models of illness and emotional distress. Standard bivariate and multivariable statistics were employed. Majority of the caregivers simultaneously held multiple models of illness, which included medical and non-medical perspectives. The GHQ-12 score were significantly lower in people who held multiple explanatory models of illness when compared to the caregivers who believed single explanations. Explanatory models affect coping in caregivers of patients with acute psychotic presentations. There is a need to have a broad-based approach to recovery and care.

  9. Presenting an Evaluation Model for the Cancer Registry Software.

    Science.gov (United States)

    Moghaddasi, Hamid; Asadi, Farkhondeh; Rabiei, Reza; Rahimi, Farough; Shahbodaghi, Reihaneh

    2017-12-01

    As cancer is increasingly growing, cancer registry is of great importance as the main core of cancer control programs, and many different software has been designed for this purpose. Therefore, establishing a comprehensive evaluation model is essential to evaluate and compare a wide range of such software. In this study, the criteria of the cancer registry software have been determined by studying the documents and two functional software of this field. The evaluation tool was a checklist and in order to validate the model, this checklist was presented to experts in the form of a questionnaire. To analyze the results of validation, an agreed coefficient of %75 was determined in order to apply changes. Finally, when the model was approved, the final version of the evaluation model for the cancer registry software was presented. The evaluation model of this study contains tool and method of evaluation. The evaluation tool is a checklist including the general and specific criteria of the cancer registry software along with their sub-criteria. The evaluation method of this study was chosen as a criteria-based evaluation method based on the findings. The model of this study encompasses various dimensions of cancer registry software and a proper method for evaluating it. The strong point of this evaluation model is the separation between general criteria and the specific ones, while trying to fulfill the comprehensiveness of the criteria. Since this model has been validated, it can be used as a standard to evaluate the cancer registry software.

  10. Analyzing musculoskeletal neck pain, measured as present pain and periods of pain, with three different regression models: a cohort study

    Directory of Open Access Journals (Sweden)

    Hagberg Mats

    2009-06-01

    Full Text Available Abstract Background In the literature there are discussions on the choice of outcome and the need for more longitudinal studies of musculoskeletal disorders. The general aim of this longitudinal study was to analyze musculoskeletal neck pain, in a group of young adults. Specific aims were to determine whether psychosocial factors, computer use, high work/study demands, and lifestyle are long-term or short-term factors for musculoskeletal neck pain, and whether these factors are important for developing or ongoing musculoskeletal neck pain. Methods Three regression models were used to analyze the different outcomes. Pain at present was analyzed with a marginal logistic model, for number of years with pain a Poisson regression model was used and for developing and ongoing pain a logistic model was used. Presented results are odds ratios and proportion ratios (logistic models and rate ratios (Poisson model. The material consisted of web-based questionnaires answered by 1204 Swedish university students from a prospective cohort recruited in 2002. Results Perceived stress was a risk factor for pain at present (PR = 1.6, for developing pain (PR = 1.7 and for number of years with pain (RR = 1.3. High work/study demands was associated with pain at present (PR = 1.6; and with number of years with pain when the demands negatively affect home life (RR = 1.3. Computer use pattern (number of times/week with a computer session ≥ 4 h, without break was a risk factor for developing pain (PR = 1.7, but also associated with pain at present (PR = 1.4 and number of years with pain (RR = 1.2. Among life style factors smoking (PR = 1.8 was found to be associated to pain at present. The difference between men and women in prevalence of musculoskeletal pain was confirmed in this study. It was smallest for the outcome ongoing pain (PR = 1.4 compared to pain at present (PR = 2.4 and developing pain (PR = 2.5. Conclusion By using different regression models different

  11. Development of Presentation Model with Cloud Based Infrastructure

    Directory of Open Access Journals (Sweden)

    Magdalena Widiantari Maria

    2018-01-01

    Full Text Available Computer mediated communication are the communication activities using technology which have rapidly in progress. Communication interactive activities nowadays has no longer only involving person to person but mediated by technology, and have been done in many fields including in education and teaching activity. In this study, presentation media based on cloud's infrastructure designed to replace face to face or in class lectures. In addition, the presentation will allow media data storage indefinitely, and accessible wherever and anytime. This is in line with the concept of student center learning where students were encouraged to more active in the lecture activities. The purpose of this research is making or designing a presentation model based on cloud‘s infrastructure. This research is using research and development method which is consists of four stages, where the first phase is composing the concept of media presentation design. The second phase are choosing the subject that will be designed as the subject of presentation. The third stage is designing presentation model. And the fourth phase is collecting materials of the subject that will be presented by each lecturer.

  12. Presenting of Indifference Management Model of Education System in Ardabil Province Using Structural Equation Modeling

    Science.gov (United States)

    Abolfazli, Elham; Saidabadi, Reza Yousefi; Fallah, Vahid

    2016-01-01

    The purpose of the present study is to investigate indifference management structural model in education system of Ardabil Province. The research method was integration study using Alli modeling. Statistical society of research was 420 assistant professors of educational science, managers, and deputies of Ardabil's second period of high schools…

  13. Present status of theories and data analyses of mathematical models for carcinogenesis

    International Nuclear Information System (INIS)

    Kai, Michiaki; Kawaguchi, Isao

    2007-01-01

    Reviewed are the basic mathematical models (hazard functions), present trend of the model studies and that for radiation carcinogenesis. Hazard functions of carcinogenesis are described for multi-stage model and 2-event model related with cell dynamics. At present, the age distribution of cancer mortality is analyzed, relationship between mutation and carcinogenesis is discussed, and models for colorectal carcinogenesis are presented. As for radiation carcinogenesis, models of Armitage-Doll and of generalized MVK (Moolgavkar, Venson, Knudson, 1971-1990) by 2-stage clonal expansion have been applied to analysis of carcinogenesis in A-bomb survivors, workers in uranium mine (Rn exposure) and smoking doctors in UK and other cases, of which characteristics are discussed. In analyses of A-bomb survivors, models above are applied to solid tumors and leukemia to see the effect, if any, of stage, age of exposure, time progression etc. In miners and smokers, stages of the initiation, promotion and progression in carcinogenesis are discussed on the analyses. Others contain the analyses of workers in Canadian atomic power plant, and of patients who underwent the radiation therapy. Model analysis can help to understand the carcinogenic process in a quantitative aspect rather than to describe the process. (R.T.)

  14. Acceptance of Addiction Prevention Exiting Methods and Presentation of Appropriate Model

    Directory of Open Access Journals (Sweden)

    Ali Asghar Savad-Kouhi

    2006-10-01

    Full Text Available Objective: The aim of this study is assessment of acceptance of addiction prevention existing methods and design and present of appropriate model. Materials & Methods: This research has done by survey and desariptive method by using questionnaire we assessed knowledge and belief of people about suggesting and existing methods of addiction prevention and their acceptence and finally design new and appropriate model of addiction prevention. For designing questionnaire, first exports and professors were openly interviewed and according their views final questionnaire was planned. We used questionnaire with 2 open ended and 61 close-ended tests for gathering data. The subjects of research were 2500 persons 13-35 years old that were selected by randomized sampling from 15 provinces. Results: The findings showed that according to people who were studied, they have positive beliefs about prevention methods and their effectiveness. According to findings a good model is inclusive model that able to do in four level: knowledge, change believe and attitude, control and change behavior. Conclusion: The people of study belive that acceptance of suggesting and existing methods of addiction prevention are effective direct and indirect to others, and appropriate model is inclusive model.

  15. Possibilistic Fuzzy Net Present Value Model and Application

    Directory of Open Access Journals (Sweden)

    S. S. Appadoo

    2014-01-01

    Full Text Available The cash flow values and the interest rate in the net present value (NPV model are usually specified by either crisp numbers or random variables. In this paper, we first discuss some of the recent developments in possibility theory and find closed form expressions for fuzzy possibilistic net present value (FNPV. Then, following Carlsson and Fullér (2001, we discuss some of the possibilistic moments related to FNPV model along with an illustrative numerical example. We also give a unified approach to find higher order moments of FNPV by using the moment generating function introduced by Paseka et al. (2011.

  16. Building models for marketing decisions : Past, present and future

    NARCIS (Netherlands)

    Leeflang, PSH; Wittink, DR

    We review five eras of model building in marketing, with special emphasis on the fourth and the fifth eras, the present and the future. At many firms managers now routinely use model-based results for marketing decisions. Given an increasing number of successful applications, the demand for models

  17. Robust Synchronization Models for Presentation System Using SMIL-Driven Approach

    Science.gov (United States)

    Asnawi, Rustam; Ahmad, Wan Fatimah Wan; Rambli, Dayang Rohaya Awang

    2013-01-01

    Current common Presentation System (PS) models are slide based oriented and lack synchronization analysis either with temporal or spatial constraints. Such models, in fact, tend to lead to synchronization problems, particularly on parallel synchronization with spatial constraints between multimedia element presentations. However, parallel…

  18. Modeling population exposures to silver nanoparticles present in consumer products

    Science.gov (United States)

    Royce, Steven G.; Mukherjee, Dwaipayan; Cai, Ting; Xu, Shu S.; Alexander, Jocelyn A.; Mi, Zhongyuan; Calderon, Leonardo; Mainelis, Gediminas; Lee, KiBum; Lioy, Paul J.; Tetley, Teresa D.; Chung, Kian Fan; Zhang, Junfeng; Georgopoulos, Panos G.

    2014-11-01

    Exposures of the general population to manufactured nanoparticles (MNPs) are expected to keep rising due to increasing use of MNPs in common consumer products (PEN 2014). The present study focuses on characterizing ambient and indoor population exposures to silver MNPs (nAg). For situations where detailed, case-specific exposure-related data are not available, as in the present study, a novel tiered modeling system, Prioritization/Ranking of Toxic Exposures with GIS (geographic information system) Extension (PRoTEGE), has been developed: it employs a product life cycle analysis (LCA) approach coupled with basic human life stage analysis (LSA) to characterize potential exposures to chemicals of current and emerging concern. The PRoTEGE system has been implemented for ambient and indoor environments, utilizing available MNP production, usage, and properties databases, along with laboratory measurements of potential personal exposures from consumer spray products containing nAg. Modeling of environmental and microenvironmental levels of MNPs employs probabilistic material flow analysis combined with product LCA to account for releases during manufacturing, transport, usage, disposal, etc. Human exposure and dose characterization further employ screening microenvironmental modeling and intake fraction methods combined with LSA for potentially exposed populations, to assess differences associated with gender, age, and demographics. Population distributions of intakes, estimated using the PRoTEGE framework, are consistent with published individual-based intake estimates, demonstrating that PRoTEGE is capable of capturing realistic exposure scenarios for the US population. Distributions of intakes are also used to calculate biologically relevant population distributions of uptakes and target tissue doses through human airway dosimetry modeling that takes into account product MNP size distributions and age-relevant physiological parameters.

  19. 3D instantaneous dynamics modeling of present-day Aegean subduction

    Science.gov (United States)

    Glerum, Anne; Spakman, Wim; van Hinsbergen, Douwe; Pranger, Casper

    2017-04-01

    To study the sensitivity of surface observables to subduction and mantle flow, i.e. the coupling of crustal tectonics and the underlying mantle dynamics, we have developed 3D numerical models of the instantaneous crust-mantle dynamics of the eastern Mediterranean. These models comprise both a realistic crust-lithosphere system and the underlying mantle. The focus for this presentation lies on the regional crustal flow response to the present-day Aegean subduction system. Our curved model domain measures 40°x40°x2900km with the Aegean subduction system taken as the geographic center. Model set-ups are based on geological and geophysical data of the eastern Mediterranean. We first create a 3D synthetic geometry of the crust-lithosphere system in a stand-alone program, including the present-day configuration of the plates in the region and crust and lithosphere thickness variations abstracted from Moho and LAB maps (Faccenna et al., 2014, Carafa et al., 2015). In addition we construct the geometry of the Aegean slab from a seismic tomography model (UU-P07; Amaru, 2007) and earthquake hypocenters (NCEDC, 2014). Geometries are then imported into the finite element code ASPECT (Kronbichler et al., 2012) using specially designed plugins. The mantle initial temperature conditions can include deviations from an adiabatic profile obtained from conversion of the UU-P07 seismic velocity anomalies to temperature anomalies using a depth-dependent scaling (Karato, 2008). We model compressible mantle flow for which material properties are obtained from thermodynamics P-T lookup-tables (Perple_X, Connolly, 2009) in combination with nonlinear viscoplastic rheology laws. Sublithospheric flow through the lateral model boundaries is left free via open boundary conditions (Chertova et al., 2012), while plate motion is prescribed at the model sides in terms of relative as well as absolute plate motion velocities (e.g. Doubrovine et al., 2012). So far, we used a free-slip surface, but

  20. Heat Pump Water Heater Modeling in EnergyPlus (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, E.; Christensen, C.

    2012-03-01

    This presentation summarizes NREL's development of a HPWH model for use in hourly building energy simulation programs, such as BEopt; this presentation was given at the Building America Stakeholder meeting on March 1, 2012, in Austin, Texas.

  1. Presenting a Model for Setting in Narrative Fiction Illustration

    Directory of Open Access Journals (Sweden)

    Hajar Salimi Namin

    2017-12-01

    Full Text Available The present research aims at presenting a model for evaluating and enhancing training the setting in illustration for narrative fictions for undergraduate students of graphic design who are weak in setting. The research utilized expert’s opinions through a survey. The designed model was submitted to eight experts, and their opinions were used to have the model adjusted and improved. Used as research instruments were notes, materials in text books, papers, and related websites, as well as questionnaires. Results indicated that, for evaluating and enhancing the level of training the setting in illustration for narrative fiction to students, one needs to extract sub-indexes of setting. Moreover, definition and recognition of the model of setting helps undergraduate students of graphic design enhance the level of setting in their works skill by recognizing details of setting. Accordingly, it is recommended to design training packages to enhance these sub-indexes and hence improve the setting for narrative fiction illustration.

  2. Nuclear model developments in FLUKA for present and future applications

    Science.gov (United States)

    Cerutti, Francesco; Empl, Anton; Fedynitch, Anatoli; Ferrari, Alfredo; Ruben, GarciaAlia; Sala, Paola R.; Smirnov, George; Vlachoudis, Vasilis

    2017-09-01

    The FLUKAS code [1-3] is used in research laboratories all around the world for challenging applications spanning a very wide range of energies, projectiles and targets. FLUKAS is also extensively used for in hadrontherapy research studies and clinical planning systems. In this paper some of the recent developments in the FLUKAS nuclear physics models of relevance for very different application fields including medical physics are presented. A few examples are shown demonstrating the effectiveness of the upgraded code.

  3. Predictive Models of Li-ion Battery Lifetime (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G.; Shi, Y.; Pesaran, A.

    2014-09-01

    Predictive models of Li-ion battery reliability must consider a multiplicity of electrochemical, thermal and mechanical degradation modes experienced by batteries in application environments. Complicating matters, Li-ion batteries can experience several path dependent degradation trajectories dependent on storage and cycling history of the application environment. Rates of degradation are controlled by factors such as temperature history, electrochemical operating window, and charge/discharge rate. Lacking accurate models and tests, lifetime uncertainty must be absorbed by overdesign and warranty costs. Degradation models are needed that predict lifetime more accurately and with less test data. Models should also provide engineering feedback for next generation battery designs. This presentation reviews both multi-dimensional physical models and simpler, lumped surrogate models of battery electrochemical and mechanical degradation. Models are compared with cell- and pack-level aging data from commercial Li-ion chemistries. The analysis elucidates the relative importance of electrochemical and mechanical stress-induced degradation mechanisms in real-world operating environments. Opportunities for extending the lifetime of commercial battery systems are explored.

  4. Mean field theory of nuclei and shell model. Present status and future outlook

    International Nuclear Information System (INIS)

    Nakada, Hitoshi

    2003-01-01

    Many of the recent topics of the nuclear structure are concerned on the problems of unstable nuclei. It has been revealed experimentally that the nuclear halos and the neutron skins as well as the cluster structures or the molecule-like structures can be present in the unstable nuclei, and the magic numbers well established in the stable nuclei disappear occasionally while new ones appear. The shell model based on the mean field approximation has been successfully applied to stable nuclei to explain the nuclear structure as the finite many body system quantitatively and it is considered as the standard model at present. If the unstable nuclei will be understood on the same model basis or not is a matter related to fundamental principle of nuclear structure theories. In this lecture, the fundamental concept and the framework of the theory of nuclear structure based on the mean field theory and the shell model are presented to make clear the problems and to suggest directions for future researches. At first fundamental properties of nuclei are described under the subtitles: saturation and magic numbers, nuclear force and effective interactions, nuclear matter, and LS splitting. Then the mean field theory is presented under subtitles: the potential model, the mean field theory, Hartree-Fock approximation for nuclear matter, density dependent force, semiclassical mean field theory, mean field theory and symmetry, Skyrme interaction and density functional, density matrix expansion, finite range interactions, effective masses, and motion of center of mass. The subsequent section is devoted to the shell model with the subtitles: beyond the mean field approximation, core polarization, effective interaction of shell model, one-particle wave function, nuclear deformation and shell model, and shell model of cross shell. Finally structure of unstable nuclei is discussed with the subtitles: general remark on the study of unstable nuclear structure, asymptotic behavior of wave

  5. Presenting the students’ academic achievement causal model based on goal orientation

    Directory of Open Access Journals (Sweden)

    EBRAHIM NASIRI

    2017-10-01

    Full Text Available Introduction: Several factors play a role in academic achievement, individual’s excellence and capability to do actions and tasks that the learner is in charge of in learning areas. The main goal of this study was to present academic achievement causal model based on the dimensions of goal orientation and learning approaches among the students of Medical Science and Dentistry courses in Guilan University of Medical Sciences in 2013. Methods: This study is based on a cross-sectional model. The participants included 175 first and second year students of the Medical and Dentistry schools in Guilan University of Medical Sciences selected by random cluster sampling [121 persons (69% Medical Basic Science students and 54 (30.9% Dentistry students]. The measurement tool included the Goal Orientation Scale of Bouffard and Study Process Questionnaire of Biggs and the students’ Grade Point Average. The study data were analyzed using Pearson correlation coefficient and structural equations modeling. SPSS 14 and Amos were used to analyze the data. Results: The results indicated a significant relationship between goal orientation and learning strategies (P<0.05. In addition, the results revealed that a significant relationship exists between learning strategies [Deep Learning (r=0.37, P<0.05, Surface Learning (r=-0.21, P<0.05], and academic achievement. The suggested model of research is fitted to the data of the research. Conclusion: Results showed that the students’ academic achievement model fits with experimental data, so it can be used in learning principles which lead to students’ achievement in learning.

  6. A binomial random sum of present value models in investment analysis

    OpenAIRE

    Βουδούρη, Αγγελική; Ντζιαχρήστος, Ευάγγελος

    1997-01-01

    Stochastic present value models have been widely adopted in financial theory and practice and play a very important role in capital budgeting and profit planning. The purpose of this paper is to introduce a binomial random sum of stochastic present value models and offer an application in investment analysis.

  7. [DESCRIPTION AND PRESENTATION OF THE RESULTS OF ELECTROENCEPHALOGRAM PROCESSING USING AN INFORMATION MODEL].

    Science.gov (United States)

    Myznikov, I L; Nabokov, N L; Rogovanov, D Yu; Khankevich, Yu R

    2016-01-01

    The paper proposes to apply the informational modeling of correlation matrix developed by I.L. Myznikov in early 1990s in neurophysiological investigations, such as electroencephalogram recording and analysis, coherence description of signals from electrodes on the head surface. The authors demonstrate information models built using the data from studies of inert gas inhalation by healthy human subjects. In the opinion of the authors, information models provide an opportunity to describe physiological processes with a high level of generalization. The procedure of presenting the EEG results holds great promise for the broad application.

  8. Behavioural present value

    OpenAIRE

    Krzysztof Piasecki

    2013-01-01

    Impact of chosen behavioural factors on imprecision of present value is discussed here. The formal model of behavioural present value is offered as a result of this discussion. Behavioural present value is described here by fuzzy set. These considerations were illustrated by means of extensive numerical case study. Finally there are shown that in proposed model the return rate is given, as a fuzzy probabilistic set.

  9. Modelling of present and future hydrology and solute transport at Forsmark. SR-Site Biosphere

    Energy Technology Data Exchange (ETDEWEB)

    Bosson, Emma (Swedish Nuclear Fuel and Waste Management Co., Stocholm (Sweden)); Sassner, Mona; Sabel, Ulrika; Gustafsson, Lars-Goeran (DHI Sverige AB (Sweden))

    2010-10-15

    Radioactive waste from nuclear power plants in Sweden is managed by the Swedish Nuclear Fuel and Waste Management Co, SKB. SKB has performed site investigations at two different locations in Sweden, referred to as the Forsmark and Laxemar-Simpevarp areas, with the objective of siting a final repository for high-level radioactive waste. In 2009 a decision was made to focus on the Forsmark site. This decision was based on a large amount of empirical evidence suggesting Forsmark to be more suitable for a geological repository /SKB 2010b/. This report presents model results of numerical flow and transport modelling of surface water and near-surface groundwater at the Forsmark site for present and future conditions. Both temperate and periglacial climates have been simulated. Also different locations of the shoreline have been applied to the model, as well as different models of vegetation and Quaternary deposits. The modelling was performed using the modelling tool MIKE SHE and was based on the SDM-Site Forsmark MIKE SHE model (presented by Bosson et al. in SKB report R-08-09). The present work is a part of the biosphere modelling performed for the SR-Site safety assessment. The Forsmark area has a flat, small-scale topography. The study area is almost entirely below 20 m.a.s.l. (metres above sea level). There is a strong correlation between the topography of the ground surface and the ground water level in the Quaternary deposits (QD); thus, the surface water divides and the groundwater divides for the QD can be assumed to coincide. No major water courses flow through the catchment. Small brooks, which often dry out in the summer, connect the different sub-catchments with each other. The main lakes in the area, Lake Bolundsfjaerden, Lake Fiskarfjaerden, Lake Gaellsbotraesket and Lake Eckarfjaerden, all have sizes of less than one km2. The lakes are in general shallow. Approximately 70% of the catchment areas are covered by forest. Agricultural land is only present in

  10. Modelling of present and future hydrology and solute transport at Forsmark. SR-Site Biosphere

    International Nuclear Information System (INIS)

    Bosson, Emma; Sassner, Mona; Sabel, Ulrika; Gustafsson, Lars-Goeran

    2010-10-01

    Radioactive waste from nuclear power plants in Sweden is managed by the Swedish Nuclear Fuel and Waste Management Co, SKB. SKB has performed site investigations at two different locations in Sweden, referred to as the Forsmark and Laxemar-Simpevarp areas, with the objective of siting a final repository for high-level radioactive waste. In 2009 a decision was made to focus on the Forsmark site. This decision was based on a large amount of empirical evidence suggesting Forsmark to be more suitable for a geological repository /SKB 2010b/. This report presents model results of numerical flow and transport modelling of surface water and near-surface groundwater at the Forsmark site for present and future conditions. Both temperate and periglacial climates have been simulated. Also different locations of the shoreline have been applied to the model, as well as different models of vegetation and Quaternary deposits. The modelling was performed using the modelling tool MIKE SHE and was based on the SDM-Site Forsmark MIKE SHE model (presented by Bosson et al. in SKB report R-08-09). The present work is a part of the biosphere modelling performed for the SR-Site safety assessment. The Forsmark area has a flat, small-scale topography. The study area is almost entirely below 20 m.a.s.l. (metres above sea level). There is a strong correlation between the topography of the ground surface and the ground water level in the Quaternary deposits (QD); thus, the surface water divides and the groundwater divides for the QD can be assumed to coincide. No major water courses flow through the catchment. Small brooks, which often dry out in the summer, connect the different sub-catchments with each other. The main lakes in the area, Lake Bolundsfjaerden, Lake Fiskarfjaerden, Lake Gaellsbotraesket and Lake Eckarfjaerden, all have sizes of less than one km2. The lakes are in general shallow. Approximately 70% of the catchment areas are covered by forest. Agricultural land is only present in

  11. Adaptive Anchoring Model: How Static and Dynamic Presentations of Time Series Influence Judgments and Predictions.

    Science.gov (United States)

    Kusev, Petko; van Schaik, Paul; Tsaneva-Atanasova, Krasimira; Juliusson, Asgeir; Chater, Nick

    2018-01-01

    When attempting to predict future events, people commonly rely on historical data. One psychological characteristic of judgmental forecasting of time series, established by research, is that when people make forecasts from series, they tend to underestimate future values for upward trends and overestimate them for downward ones, so-called trend-damping (modeled by anchoring on, and insufficient adjustment from, the average of recent time series values). Events in a time series can be experienced sequentially (dynamic mode), or they can also be retrospectively viewed simultaneously (static mode), not experienced individually in real time. In one experiment, we studied the influence of presentation mode (dynamic and static) on two sorts of judgment: (a) predictions of the next event (forecast) and (b) estimation of the average value of all the events in the presented series (average estimation). Participants' responses in dynamic mode were anchored on more recent events than in static mode for all types of judgment but with different consequences; hence, dynamic presentation improved prediction accuracy, but not estimation. These results are not anticipated by existing theoretical accounts; we develop and present an agent-based model-the adaptive anchoring model (ADAM)-to account for the difference between processing sequences of dynamically and statically presented stimuli (visually presented data). ADAM captures how variation in presentation mode produces variation in responses (and the accuracy of these responses) in both forecasting and judgment tasks. ADAM's model predictions for the forecasting and judgment tasks fit better with the response data than a linear-regression time series model. Moreover, ADAM outperformed autoregressive-integrated-moving-average (ARIMA) and exponential-smoothing models, while neither of these models accounts for people's responses on the average estimation task. Copyright © 2017 The Authors. Cognitive Science published by Wiley

  12. Modelling and simulation-based acquisition decision support: present & future

    CSIR Research Space (South Africa)

    Naidoo, S

    2009-10-01

    Full Text Available stream_source_info Naidoo1_2009.pdf.txt stream_content_type text/plain stream_size 24551 Content-Encoding UTF-8 stream_name Naidoo1_2009.pdf.txt Content-Type text/plain; charset=UTF-8 1 Modelling & Simulation...-Based Acquisition Decision Support: Present & Future Shahen Naidoo Abstract The Ground Based Air Defence System (GBADS) Programme, of the South African Army has been applying modelling and simulation (M&S) to provide acquisition decision and doctrine...

  13. Modeling nonstationary extreme wave heights in present and future climates of Greek Seas

    Directory of Open Access Journals (Sweden)

    Panagiota Galiatsatou

    2016-01-01

    Full Text Available In this study the generalized extreme value (GEV distribution function was used to assess nonstationarity in annual maximum wave heights for selected locations in the Greek Seas, both in the present and future climates. The available significant wave height data were divided into groups corresponding to the present period (1951–2000, a first future period (2001–2050, and a second future period (2051–2100. For each time period, the parameters of the GEV distribution were specified as functions of time-varying covariates and estimated using the conditional density network (CDN. For each location and selected time period, a total number of 29 linear and nonlinear models were fitted to the wave data, for a given combination of covariates. The covariates used in the GEV-CDN models consisted of wind fields resulting from the Regional Climate Model version 3 (RegCM3 developed by the International Center for Theoretical Physics (ICTP with a spatial resolution of 10 km × 10 km, after being processed using principal component analysis (PCA. The results obtained from the best fitted models in the present and future periods for each location were compared, revealing different patterns of relationships between wind components and extreme wave height quantiles in different parts of the Greek Seas and different periods. The analysis demonstrates an increase of extreme wave heights in the first future period as compared with the present period, causing a significant threat to Greek coastal areas in the North Aegean Sea and the Ionian Sea.

  14. The chlorine budget of the present-day atmosphere - A modeling study

    Science.gov (United States)

    Weisenstein, Debra K.; Ko, Malcolm K. W.; Sze, Nien-Dak

    1992-01-01

    The contribution of source gases to the total amount of inorganic chlorine (ClY) is examined analytically with a time-dependent model employing 11 source gases. The source-gas emission data are described, and the modeling methodology is set forth with attention given to the data interpretation. The abundances and distributions are obtained for all 11 source gases with corresponding ClY production rates and mixing ratios. It is shown that the ClY production rate and the ClY mixing ratio for each source gas are spatially dependent, and the change in the relative contributions from 1950 to 1990 is given. Ozone changes in the past decade are characterized by losses in the polar and midlatitude lower stratosphere. The values for CFC-11, CCl4, and CH3CCl3 suggest that they are more evident in the lower stratosphere than is suggested by steady-state estimates based on surface concentrations.

  15. Modeling of present and Eemian stable water isotopes in precipitation

    DEFF Research Database (Denmark)

    Sjolte, Jesper

    The subject of this thesis is the modeling of the isotopic temperature proxies d18O, dD and deuterium excess in precipitation. Two modeling studies were carried out, one using the regional climate model, and one using a global climate model. In the regional study the model was run for the period ...... the modeled isotopes do not agree with ice core data. The discrepancy between the model output and the ice core data is attributed to the boundary conditions, where changes in ice sheets and vegetation have not been accounted for.......The subject of this thesis is the modeling of the isotopic temperature proxies d18O, dD and deuterium excess in precipitation. Two modeling studies were carried out, one using the regional climate model, and one using a global climate model. In the regional study the model was run for the period...... 1959 to 2001 using meteorological data and a domain including Greenland and the surrounding North Atlantic. The model was found to reproduce the observed seasonal variability of temperature and precipitation well. In comparison with ice core data from Greenland and observations from coastal stations...

  16. HYDROGEOLOGIC CASE STUDIES (DENVER PRESENTATION)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  17. Verification Techniques for Parameter Selection and Bayesian Model Calibration Presented for an HIV Model

    Science.gov (United States)

    Wentworth, Mami Tonoe

    Uncertainty quantification plays an important role when making predictive estimates of model responses. In this context, uncertainty quantification is defined as quantifying and reducing uncertainties, and the objective is to quantify uncertainties in parameter, model and measurements, and propagate the uncertainties through the model, so that one can make a predictive estimate with quantified uncertainties. Two of the aspects of uncertainty quantification that must be performed prior to propagating uncertainties are model calibration and parameter selection. There are several efficient techniques for these processes; however, the accuracy of these methods are often not verified. This is the motivation for our work, and in this dissertation, we present and illustrate verification frameworks for model calibration and parameter selection in the context of biological and physical models. First, HIV models, developed and improved by [2, 3, 8], describe the viral infection dynamics of an HIV disease. These are also used to make predictive estimates of viral loads and T-cell counts and to construct an optimal control for drug therapy. Estimating input parameters is an essential step prior to uncertainty quantification. However, not all the parameters are identifiable, implying that they cannot be uniquely determined by the observations. These unidentifiable parameters can be partially removed by performing parameter selection, a process in which parameters that have minimal impacts on the model response are determined. We provide verification techniques for Bayesian model calibration and parameter selection for an HIV model. As an example of a physical model, we employ a heat model with experimental measurements presented in [10]. A steady-state heat model represents a prototypical behavior for heat conduction and diffusion process involved in a thermal-hydraulic model, which is a part of nuclear reactor models. We employ this simple heat model to illustrate verification

  18. Presenting a conceptual model of data collection to manage the groundwater quality

    Directory of Open Access Journals (Sweden)

    Nourbakhsh Zahra

    2017-12-01

    Full Text Available A conceptual model was proposed in the present study, which highlighted important independent and dependent variables in order to managing the groundwater quality. Furthermore, the methods of selection of variable and collection of related data were explained. The study was carried out in the Tajan Plain, north of Iran; 50 drinking wells were considered as sampling points. In this model the Analytical Hierarchy Process (AHP was proposed to select the indicator water quality parameters. According to expert opinions and characteristics of the study area ten factors were chosen as variables influencing the quality of groundwater (land use types, lithology units, geology units, distance of wells to the outlet, distance to the residential areas, direction toward the residential areas, depth of the groundwater table, the type of aquifer, transmissivity and population. Geographic Information System (AecGIS 9.3 was used to manage the spatial-based variables and the data of non-spatial-based variables were obtained from relevant references. A database, which contains all collected data related to groundwater quality management in the studied area, was created as the output of the model. The output of this conceptual model can be used as an input for quantitative and mathematical models. Results show that 6 parameters (sulphate, iron, nitrate, electrical conductivity, calcium, and total dissolved solids (TDS were the best indicators for groundwater quality analysis in the area. More than 50% of the wells were drilled in the depth of groundwater table about 5 meters, in this low depth pollutants can load into the wells and also 78% of the wells are located within 5 km from the urban area; it can be concluded from this result that the intensive urban activities could affect groundwater quality.

  19. On a unified presentation of the non-equilibrium two-phase flow models

    International Nuclear Information System (INIS)

    Boure, J.A.

    1975-01-01

    If the various existing one-dimensional two-phase flow models are consistent, they must appear as particular cases of more general models. It is shown that such is the case if, and only if, the mathematical form of the laws of the transfers between the phases is sufficiently general. These transfer laws control the non-equilibrium phenomena. A convenient general model is a particular form of the two-fluid model. This particular form involves three equations and three dependent variables characterizing the mixture, and three equations and three dependent variables characterizing the differences between the phases (slip, thermal non-equilibriums). The mathematical expressions of the transfert terms present in the above equations involve first-order partial derivatives of the dependent variables. The other existing models may be deduced from the general model by making assumptions on the fluid evolution. Several examples are given. The resulting unified presentation of the existing model enables a comparison of the implicit assumptions made in these models on the transfer laws. It is therefore, a useful tool for the appraisal of the existing models and for the development of new models [fr

  20. PREGO (presentation of Graves' orbitopathy) study

    DEFF Research Database (Denmark)

    Perros, Petros; Žarković, Miloš; Azzolini, Claudio

    2015-01-01

    BACKGROUND/AIMS: The epidemiology of Graves' orbitopathy (GO) may be changing. The aim of the study was to identify trends in presentation of GO to tertiary centres and initial management over time. METHODS: Prospective observational study of European Group On Graves' Orbitopathy (EUGOGO) centres...

  1. Numerical modelling of present and future hydrology at Laxemar- Simpevarp

    International Nuclear Information System (INIS)

    Sassner, Mona; Sabel, Ulrika; Bosson, Emma; Berglund, Sten

    2011-04-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) has performed site investigations at two potential sites for a final repository for spent nuclear fuel. This report presents results of water flow modelling of the Laxemar area. The modelling reported in this document is focused on the near-surface groundwater, i.e. groundwater in Quaternary deposits and shallow rock, and surface water systems, and was performed using the MIKE SHE tool. The main objective of the modelling was to provide input to the radionuclide transport and dose calculations that were carried out as a part of the comparison between the Laxemar and Forsmark sites

  2. Numerical modelling of present and future hydrology at Laxemar- Simpevarp

    Energy Technology Data Exchange (ETDEWEB)

    Sassner, Mona; Sabel, Ulrika (DHI Sverige AB (Sweden)); Bosson, Emma; Berglund, Sten (Svensk Kaernbraenslehantering AB (Sweden))

    2011-04-15

    The Swedish Nuclear Fuel and Waste Management Company (SKB) has performed site investigations at two potential sites for a final repository for spent nuclear fuel. This report presents results of water flow modelling of the Laxemar area. The modelling reported in this document is focused on the near-surface groundwater, i.e. groundwater in Quaternary deposits and shallow rock, and surface water systems, and was performed using the MIKE SHE tool. The main objective of the modelling was to provide input to the radionuclide transport and dose calculations that were carried out as a part of the comparison between the Laxemar and Forsmark sites

  3. Mass gathering medicine: a predictive model for patient presentation and transport rates.

    Science.gov (United States)

    Arbon, P; Bridgewater, F H; Smith, C

    2001-01-01

    This paper reports on research into the influence of environmental factors (including crowd size, temperature, humidity, and venue type) on the number of patients and the patient problems presenting to first-aid services at large, public events in Australia. Regression models were developed to predict rates of patient presentation and of transportation-to-a-hospital for future mass gatherings. To develop a data set and predictive model that can be applied across venues and types of mass gathering events that is not venue or event specific. Data collected will allow informed event planning for future mass gatherings for which health care services are required. Mass gatherings were defined as public events attended by in excess of 25,000 people. Over a period of 12 months, 201 mass gatherings attended by a combined audience in excess of 12 million people were surveyed throughout Australia. The survey was undertaken by St. John Ambulance Australia personnel. The researchers collected data on the incidence and type of patients presenting for treatment and on the environmental factors that may influence these presentations. A standard reporting format and definition of event geography was employed to overcome the event-specific nature of many previous surveys. There are 11,956 patients in the sample. The patient presentation rate across all event types was 0.992/1,000 attendees, and the transportation-to-hospital rate was 0.027/1,000 persons in attendance. The rates of patient presentations declined slightly as crowd sizes increased. The weather (particularly the relative humidity) was related positively to an increase in the rates of presentations. Other factors that influenced the number and type of patients presenting were the mobility of the crowd, the availability of alcohol, the event being enclosed by a boundary, and the number of patient-care personnel on duty. Three regression models were developed to predict presentation rates at future events. Several

  4. Alligator Rivers Analogue project. Geochemical modelling of present-day groundwaters. Final Report - Volume 12

    Energy Technology Data Exchange (ETDEWEB)

    Sverjensky, D A [The John Hopkins Univ, Dept of Earth and Planetary Sciences, Baltimore (United States)

    1993-12-31

    The main purpose of this report is to summarize geochemical modeling studies of the present-day Koongarra groundwaters. Information on the present-day geochemistry and geochemical processes at Koongarra forms a basis for a present-day analogue for nuclear waste migration. The present-day analogue is built on studies of the mineralogy and petrology of the Koongarra deposit, and chemical analyses of present-day groundwaters from the deposit. The overall approach taken in the present study has been to carry out a series of aqueous speciation and state of saturation calculations, including chemical mass transfer calculations, to address the possible control over the chemistry of the present-day for the groundwaters at Koongarra. The most important implication of the present study for the migration of radionuclides is the strong role played by the water-rock interactions, both above and below the water table, influencing the overall chemical evolution of the groundwaters. Thus, the results show that the chemical evolution of waters is strongly controlled by the initial availability of CO{sub 2} and the mineral assemblage encountered, which together determine the major element evolution of the waters by controlling the pH. The relative rates of evolution of the pH and the oxidation state of the groundwaters are also critical to the mobility of uranium. The shallow Koongarra waters are sufficiently oxidising that they can dissolve and transport uranium even under acidic conditions. Under the more reducing condition of the deep groundwaters, is the pH level that permits uranium transport as carbonate complexes. However, if the oxidation state decreases to much lower levels, it would be expected that uranium become immobile. All the speciation and state of saturation calculations carried out in the present study are available from the author, on request 22 refs., 7 tabs., 18 figs.

  5. Alligator Rivers Analogue project. Geochemical modelling of present-day groundwaters. Final Report - Volume 12

    Energy Technology Data Exchange (ETDEWEB)

    Sverjensky, D. A. [The John Hopkins Univ, Dept of Earth and Planetary Sciences, Baltimore (United States)

    1992-12-31

    The main purpose of this report is to summarize geochemical modeling studies of the present-day Koongarra groundwaters. Information on the present-day geochemistry and geochemical processes at Koongarra forms a basis for a present-day analogue for nuclear waste migration. The present-day analogue is built on studies of the mineralogy and petrology of the Koongarra deposit, and chemical analyses of present-day groundwaters from the deposit. The overall approach taken in the present study has been to carry out a series of aqueous speciation and state of saturation calculations, including chemical mass transfer calculations, to address the possible control over the chemistry of the present-day for the groundwaters at Koongarra. The most important implication of the present study for the migration of radionuclides is the strong role played by the water-rock interactions, both above and below the water table, influencing the overall chemical evolution of the groundwaters. Thus, the results show that the chemical evolution of waters is strongly controlled by the initial availability of CO{sub 2} and the mineral assemblage encountered, which together determine the major element evolution of the waters by controlling the pH. The relative rates of evolution of the pH and the oxidation state of the groundwaters are also critical to the mobility of uranium. The shallow Koongarra waters are sufficiently oxidising that they can dissolve and transport uranium even under acidic conditions. Under the more reducing condition of the deep groundwaters, is the pH level that permits uranium transport as carbonate complexes. However, if the oxidation state decreases to much lower levels, it would be expected that uranium become immobile. All the speciation and state of saturation calculations carried out in the present study are available from the author, on request 22 refs., 7 tabs., 18 figs.

  6. Statistical Model of the 2001 Czech Census for Interactive Presentation

    Czech Academy of Sciences Publication Activity Database

    Grim, Jiří; Hora, Jan; Boček, Pavel; Somol, Petr; Pudil, Pavel

    Vol. 26, č. 4 (2010), s. 1-23 ISSN 0282-423X R&D Projects: GA ČR GA102/07/1594; GA MŠk 1M0572 Grant - others:GA MŠk(CZ) 2C06019 Institutional research plan: CEZ:AV0Z10750506 Keywords : Interactive statistical model * census data presentation * distribution mixtures * data modeling * EM algorithm * incomplete data * data reproduction accuracy * data mining Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.492, year: 2010 http://library.utia.cas.cz/separaty/2010/RO/grim-0350513.pdf

  7. Modelling economic losses of historic and present-day high-impact winter storms in Switzerland

    Science.gov (United States)

    Welker, Christoph; Martius, Olivia; Stucki, Peter; Bresch, David; Dierer, Silke; Brönnimann, Stefan

    2015-04-01

    simulate the wind field and related economic impact of both historic and present-day high-impact winter storms in Switzerland since end of the 19th century. Our technique involves the dynamical downscaling of the 20CR to 3 km horizontal resolution using the numerical Weather Research and Forecasting model and the subsequent loss simulation using an open-source impact model. This impact model estimates, for modern economic and social conditions, storm-related economic losses at municipality level, and thus allows a numerical simulation of the impact from both historic and present-day severe winter storms in Switzerland on a relatively fine spatial scale. In this study, we apply the modelling chain to a storm sample of almost 90 high-impact winter storms in Switzerland since 1871, and we are thus able to make a statement of the typical wind and loss patterns of hazardous windstorms in Switzerland. To evaluate our modelling chain, we compare simulated storm losses with insurance loss data for the present-day windstorms "Lothar" and "Joachim" in December 1999 and December 2011, respectively. Our study further includes a range of sensitivity experiments and a discussion of the main sources of uncertainty.

  8. Advanced Models and Controls for Prediction and Extension of Battery Lifetime (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G.; Pesaran, A.

    2014-02-01

    Predictive models of capacity and power fade must consider a multiplicity of degradation modes experienced by Li-ion batteries in the automotive environment. Lacking accurate models and tests, lifetime uncertainty must presently be absorbed by overdesign and excess warranty costs. To reduce these costs and extend life, degradation models are under development that predict lifetime more accurately and with less test data. The lifetime models provide engineering feedback for cell, pack and system designs and are being incorporated into real-time control strategies.

  9. Presentation of a Novel Model for Evaluation of Commercialization of Research and Development: Case Study of the Pharmaceutical Biotechnology Industry.

    Science.gov (United States)

    Emami, Hassan; Radfar, Reza

    2017-01-01

    The current situation in Iran suggests an appropriate basis for developing biotechnology industries, because the patents for the majority of hi-tech medicines registered in developed countries are ending. Biosimilar and technology-oriented companies which do not have patents will have the opportunity to enter the biosimilar market and move toward innovative initiatives. The present research proposed a model by which one can evaluate commercialization of achievements obtained from research with a focus on the pharmaceutical biotechnology industry. This is a descriptive-analytic study where mixed methodology is followed by a heuristic approach. The statistical population was pharmaceutical biotechnology experts at universities and research centers in Iran. Structural equations were employed in this research. The results indicate that there are three effective layers within commercialization in the proposed model. These are a general layer (factors associated with management, human capital, legal infrastructure, communication infrastructure, a technical and executive infrastructures, and financial factors), industrial layer (internal industrial factors and pharmaceutical industry factors), and a third layer that included national and international aspects. These layers comprise 6 domains, 21 indices, 41 dimensions, and 126 components. Compilation of these layers (general layer, industrial layer, and national and international aspects) can serve commercialization of research and development as an effective evaluation package.

  10. KioskAR: An Augmented Reality Game as a New Business Model to Present Artworks

    Directory of Open Access Journals (Sweden)

    Yoones A. Sekhavat

    2016-01-01

    Full Text Available This paper presents the architecture of KioskAR, which is a pervasive game implemented using augmented reality (AR. This game introduces a new business model that makes it possible for players to present their artworks in virtual kiosks using augmented reality, while they are having fun playing the game. In addition to competition between the players in the game, this game requires social interaction between players to earn more points. A user study is conducted to evaluate the sense of presence and the usability of the application. The results of experiments show that KioskAR can achieve a high level of usability as well as sense of presence.

  11. Pitting corrosion of copper. Further model studies

    International Nuclear Information System (INIS)

    Taxen, C.

    2002-08-01

    The work presented in this report is a continuation and expansion of a previous study. The aim of the work is to provide background information about pitting corrosion of copper for a safety analysis of copper canisters for final deposition of radioactive waste. A mathematical model for the propagation of corrosion pits is used to estimate the conditions required for stationary propagation of a localised anodic corrosion process. The model uses equilibrium data for copper and its corrosion products and parameters for the aqueous mass transport of dissolved species. In the present work we have, in the model, used a more extensive set of aqueous and solid compounds and equilibrium data from a different source. The potential dependence of pitting in waters with different compositions is studied in greater detail. More waters have been studied and single parameter variations in the composition of the water have been studied over wider ranges of concentration. The conclusions drawn in the previous study are not contradicted by the present results. However, the combined effect of potential and water composition on the possibility of pitting corrosion is more complex than was realised. In the previous study we found what seemed to be a continuous aggravation of a pitting situation by increasing potentials. The present results indicate that pitting corrosion can take place only over a certain potential range and that there is an upper potential limit for pitting as well as a lower. A sensitivity analysis indicates that the model gives meaningful predictions of the minimum pitting potential also when relatively large errors in the input parameters are allowed for

  12. Encoding instructions and stimulus presentation in local environmental context-dependent memory studies.

    Science.gov (United States)

    Markopoulos, G; Rutherford, A; Cairns, C; Green, J

    2010-08-01

    Murnane and Phelps (1993) recommend word pair presentations in local environmental context (EC) studies to prevent associations being formed between successively presented items and their ECs and a consequent reduction in the EC effect. Two experiments were conducted to assess the veracity of this assumption. In Experiment 1, participants memorised single words or word pairs, or categorised them as natural or man made. Their free recall protocols were examined to assess any associations established between successively presented items. Fewest associations were observed when the item-specific encoding task (i.e., natural or man made categorisation of word referents) was applied to single words. These findings were examined further in Experiment 2, where the influence of encoding instructions and stimulus presentation on local EC dependent recognition memory was examined. Consistent with recognition dual-process signal detection model predictions and findings (e.g., Macken, 2002; Parks & Yonelinas, 2008), recollection sensitivity, but not familiarity sensitivity, was found to be local EC dependent. However, local EC dependent recognition was observed only after item-specific encoding instructions, irrespective of stimulus presentation. These findings and the existing literature suggest that the use of single word presentations and item-specific encoding enhances local EC dependent recognition.

  13. Presenting a new kinetic model for methanol to light olefins reactions over a hierarchical SAPO-34 catalyst using the Langmuir-Hinshelwood-Hougen-Watson mechanism

    Science.gov (United States)

    Javad Azarhoosh, Mohammad; Halladj, Rouein; Askari, Sima

    2017-10-01

    In this study, a new kinetic model for methanol to light olefins (MTO) reactions over a hierarchical SAPO-34 catalyst using the Langmuir-Hinshelwood-Hougen-Watson (LHHW) mechanism was presented and the kinetic parameters was obtained using a genetic algorithm (GA) and genetic programming (GP). Several kinetic models for the MTO reactions have been presented. However, due to the complexity of the reactions, most reactions are considered lumped and elementary, which cannot be deemed a completely accurate kinetic model of the process. Therefore, in this study, the LHHW mechanism is presented as kinetic models of MTO reactions. Because of the non-linearity of the kinetic models and existence of many local optimal points, evolutionary algorithms (GA and GP) are used in this study to estimate the kinetic parameters in the rate equations. Via the simultaneous connection of the code related to modelling the reactor and the GA and GP codes in the MATLAB R2013a software, optimization of the kinetic models parameters was performed such that the least difference between the results from the kinetic models and experiential results was obtained and the best kinetic parameters of MTO process reactions were achieved. A comparison of the results from the model with experiential results showed that the present model possesses good accuracy.

  14. A review of the evidence linking adult attachment theory and chronic pain: presenting a conceptual model.

    Science.gov (United States)

    Meredith, Pamela; Ownsworth, Tamara; Strong, Jenny

    2008-03-01

    It is now well established that pain is a multidimensional phenomenon, affected by a gamut of psychosocial and biological variables. According to diathesis-stress models of chronic pain, some individuals are more vulnerable to developing disability following acute pain because they possess particular psychosocial vulnerabilities which interact with physical pathology to impact negatively upon outcome. Attachment theory, a theory of social and personality development, has been proposed as a comprehensive developmental model of pain, implicating individual adult attachment pattern in the ontogenesis and maintenance of chronic pain. The present paper reviews and critically appraises studies which link adult attachment theory with chronic pain. Together, these papers offer support for the role of insecure attachment as a diathesis (or vulnerability) for problematic adjustment to pain. The Attachment-Diathesis Model of Chronic Pain developed from this body of literature, combines adult attachment theory with the diathesis-stress approach to chronic pain. The evidence presented in this review, and the associated model, advances our understanding of the developmental origins of chronic pain conditions, with potential application in guiding early pain intervention and prevention efforts, as well as tailoring interventions to suit specific patient needs.

  15. A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome.

    Directory of Open Access Journals (Sweden)

    Phung Khanh Lam

    Full Text Available To identify risk factors and develop a prediction model for the development of profound and recurrent shock amongst children presenting with dengue shock syndrome (DSS.We analyzed data from a prospective cohort of children with DSS recruited at the Paediatric Intensive Care Unit of the Hospital for Tropical Disease in Ho Chi Minh City, Vietnam. The primary endpoint was "profound DSS", defined as ≥2 recurrent shock episodes (for subjects presenting in compensated shock, or ≥1 recurrent shock episodes (for subjects presenting initially with decompensated/hypotensive shock, and/or requirement for inotropic support. Recurrent shock was evaluated as a secondary endpoint. Risk factors were pre-defined clinical and laboratory variables collected at the time of presentation with shock. Prognostic model development was based on logistic regression and compared to several alternative approaches.The analysis population included 1207 children of whom 222 (18% progressed to "profound DSS" and 433 (36% had recurrent shock. Independent risk factors for both endpoints included younger age, earlier presentation, higher pulse rate, higher temperature, higher haematocrit and, for females, worse hemodynamic status at presentation. The final prognostic model for "profound DSS" showed acceptable discrimination (AUC=0.69 for internal validation and calibration and is presented as a simple score-chart.Several risk factors for development of profound or recurrent shock among children presenting with DSS were identified. The score-chart derived from the prognostic models should improve triage and management of children presenting with DSS in dengue-endemic areas.

  16. Geochemical modelling and speciation studies of metal pollutants present in selected water systems in South Africa

    Science.gov (United States)

    Magu, M. M.; Govender, P. P.; Ngila, J. C.

    2016-04-01

    Metal pollutants in water poses great threats to living beings and hence requires to be monitored regularly to avoid loss of lives. Various analytical methods are available to monitor these pollutants in water and can be improved with time. Modelling of metal pollutants in any water system helps chemists, engineers and environmentalists to greatly understand the various chemical processes in such systems. Water samples were collected from waste water treatment plant and river from highlands close to its source all the way to the ocean as it passing through areas with high anthropogenic activities. Pre-concentration of pollutants in the samples was done through acid digestion and metal pollutants were analysed using inductively coupled plasma-optical emission spectra (ICP-OES) to determine the concentration levels. Metal concentrations ranged between 0.1356-0.4658 mg/L for Al; 0.0031-0.0050 mg/L for Co, 0.0019-0.0956 mg/L for Cr; 0.0028-0.3484 mg/L for Cu; 0.0489-0.3474 mg/L for Fe; 0.0033-0.0285 mg/L for Mn; 0.0056-0.0222 mg/L for Ni; 0.0265-0.4753 mg/L for Pb and 0.0052-0.5594 mg/L for Zn. Modelling work was performed using PHREEQC couple with Geochemist's workbench (GWB) to determine speciation dynamics and bioavailability of these pollutants. Modelling thus adds value to analytical methods and hence a better complementary tool to laboratory-based experimental studies.

  17. Presentation on the Modeling and Educational Demonstrations Laboratory Curriculum Materials Center (MEDL-CMC): A Working Model and Progress Report

    Science.gov (United States)

    Glesener, G. B.; Vican, L.

    2015-12-01

    Physical analog models and demonstrations can be effective educational tools for helping instructors teach abstract concepts in the Earth, planetary, and space sciences. Reducing the learning challenges for students using physical analog models and demonstrations, however, can often increase instructors' workload and budget because the cost and time needed to produce and maintain such curriculum materials is substantial. First, this presentation describes a working model for the Modeling and Educational Demonstrations Laboratory Curriculum Materials Center (MEDL-CMC) to support instructors' use of physical analog models and demonstrations in the science classroom. The working model is based on a combination of instructional resource models developed by the Association of College & Research Libraries and by the Physics Instructional Resource Association. The MEDL-CMC aims to make the curriculum materials available for all science courses and outreach programs within the institution where the MEDL-CMC resides. The sustainability and value of the MEDL-CMC comes from its ability to provide and maintain a variety of physical analog models and demonstrations in a wide range of science disciplines. Second, the presentation then reports on the development, progress, and future of the MEDL-CMC at the University of California Los Angeles (UCLA). Development of the UCLA MEDL-CMC was funded by a grant from UCLA's Office of Instructional Development and is supported by the Department of Earth, Planetary, and Space Sciences. Other UCLA science departments have recently shown interest in the UCLA MEDL-CMC services, and therefore, preparations are currently underway to increase our capacity for providing interdepartmental service. The presentation concludes with recommendations and suggestions for other institutions that wish to start their own MEDL-CMC in order to increase educational effectiveness and decrease instructor workload. We welcome an interuniversity collaboration to

  18. Presenting Numerical Modelling of Explosive Volcanic Eruption to a General Public

    Science.gov (United States)

    Demaria, C.; Todesco, M.; Neri, A.; Blasi, G.

    2001-12-01

    Numerical modeling of explosive volcanic eruptions has been widely applied, during the last decades, to study pyroclastic flows dispersion along volcano's flanks and to evaluate their impact on urban areas. Results from these transient multi-phase and multi-component simulations are often reproduced in form of computer animations, representing the spatial and temporal evolution of relevant flow variables (such as temperature, or particle concentration). Despite being a sophisticated, technical tool to analyze and share modeling results within the scientific community, these animations truly look like colorful cartoons showing an erupting volcano and are especially suited to be shown to a general public. Thanks to their particular appeal, and to the large interest usually risen by exploding volcanoes, these animations have been presented several times on television and magazines and are currently displayed in a permanent exposition, at the Vesuvius Observatory in Naples. This work represents an effort to produce an accompanying tool for these animations, capable of explaining to a large audience the scientific meaning of what can otherwise look as a graphical exercise. Dealing with research aimed at the study of dangerous, explosive volcanoes, improving the general understanding of these scientific results plays an important role as far as risk perception is concerned. An educated population has better chances to follow an appropriate behavior, i.e.: one that could lead, on the long period, to a reduction of the potential risk. In this sense, a correct divulgation of scientific results, while improving the confidence of the population in the scientific community, should belong to the strategies adopted to mitigate volcanic risk. Due to the relevance of the long term final goal of such divulgation experiment, this work represents an interdisciplinary effort, combining scientific expertise and specific competence from the modern communication science and risk

  19. Simulation of the present-day climate with the climate model INMCM5

    Science.gov (United States)

    Volodin, E. M.; Mortikov, E. V.; Kostrykin, S. V.; Galin, V. Ya.; Lykossov, V. N.; Gritsun, A. S.; Diansky, N. A.; Gusev, A. V.; Iakovlev, N. G.

    2017-12-01

    In this paper we present the fifth generation of the INMCM climate model that is being developed at the Institute of Numerical Mathematics of the Russian Academy of Sciences (INMCM5). The most important changes with respect to the previous version (INMCM4) were made in the atmospheric component of the model. Its vertical resolution was increased to resolve the upper stratosphere and the lower mesosphere. A more sophisticated parameterization of condensation and cloudiness formation was introduced as well. An aerosol module was incorporated into the model. The upgraded oceanic component has a modified dynamical core optimized for better implementation on parallel computers and has two times higher resolution in both horizontal directions. Analysis of the present-day climatology of the INMCM5 (based on the data of historical run for 1979-2005) shows moderate improvements in reproduction of basic circulation characteristics with respect to the previous version. Biases in the near-surface temperature and precipitation are slightly reduced compared with INMCM4 as well as biases in oceanic temperature, salinity and sea surface height. The most notable improvement over INMCM4 is the capability of the new model to reproduce the equatorial stratospheric quasi-biannual oscillation and statistics of sudden stratospheric warmings.

  20. Presenting a practical model for governmental political mapping on road traffic injuries in Iran in 2008: a qualitative study.

    Science.gov (United States)

    Ainy, E; Soori, Hamid; Mahfozphoor, S; Movahedinejad, Aa

    2011-10-01

    This study was conducted to assess political mapping in relation to road traffic injuries (RTIs) management and prevention to present a practical model for RTIs. A phenomenological qualitative study was developed to identify stakeholders on RTI in Iran in 2008. The designed questions were discussed by systematic discussion with the relevant specialists. After receiving written consent from the main responsible stakeholders, the questionnaire was filled in by trained experts. Themes were determined and content was analysed in each part. Main responsible stakeholders. By comparing other countries' political mappings which were found in the library and by Internet searching, political mapping of RTI in Iran was suggested. Subjects were 26 experts from governmental and non-governmental organizations. The main proposed leading agencies were traffic police and presidency (13% each). Findings showed that only 31% of our political mapping was formed according to the World Health Organization (WHO). In 94% of cases, the involved organizations had unspecified roles; the reason was poor monitoring for RTI in 39% of organizations. Lack of adequate authority and suitable legislation, appropriate laws and tasks definition were 94% and 18%, respectively. The most essential policy to overcome problems was defined as appropriate legislation (21%), and the most frequent type of support needed was mentioned as adequate budgeting (25%). Traffic police can play the leading agency role by government support, with strong leadership, appropriate legislation, defined tasks and adequate budget.

  1. Genesis and evolution of the Skyrme model from 1954 to the present

    International Nuclear Information System (INIS)

    Sanyuk, V.I.

    1994-01-01

    Not widely known facts on the genesis of the Skyrme model are presented in a historical survey, based on Skyrme's earliest papers and on his own published remembrance. We consider the evolution of Skyrme's model description of nuclear matter from the ''Mesonic Fluid'' model up to its final version, known as the baryon model. We pay special tribute to some well-known ideas in contemporary particle physics which one can find in Skyrme's earlier papers, such as: Nuclear Democracy, the Solitonic Mechanism, the Nonlinear Realization of Chiral Symmetry, Topological Charges, Fermi-Bose Transmutation, etc. It is curious to note in the final version of the Skyrme model gleams of Kelvin's ''Vortex Atoms'' theory. In conclusion we make a brief analysis of the validity of Skyrme's conjectures in view of recent results and pinpoint some questions which still remain. (author). 93 refs, 4 figs

  2. Quasi-experimental study designs series-paper 10: synthesizing evidence for effects collected from quasi-experimental studies presents surmountable challenges.

    Science.gov (United States)

    Becker, Betsy Jane; Aloe, Ariel M; Duvendack, Maren; Stanley, T D; Valentine, Jeffrey C; Fretheim, Atle; Tugwell, Peter

    2017-09-01

    To outline issues of importance to analytic approaches to the synthesis of quasi-experiments (QEs) and to provide a statistical model for use in analysis. We drew on studies of statistics, epidemiology, and social-science methodology to outline methods for synthesis of QE studies. The design and conduct of QEs, effect sizes from QEs, and moderator variables for the analysis of those effect sizes were discussed. Biases, confounding, design complexities, and comparisons across designs offer serious challenges to syntheses of QEs. Key components of meta-analyses of QEs were identified, including the aspects of QE study design to be coded and analyzed. Of utmost importance are the design and statistical controls implemented in the QEs. Such controls and any potential sources of bias and confounding must be modeled in analyses, along with aspects of the interventions and populations studied. Because of such controls, effect sizes from QEs are more complex than those from randomized experiments. A statistical meta-regression model that incorporates important features of the QEs under review was presented. Meta-analyses of QEs provide particular challenges, but thorough coding of intervention characteristics and study methods, along with careful analysis, should allow for sound inferences. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Surviving the present: Modeling tools for organizational change

    International Nuclear Information System (INIS)

    Pangaro, P.

    1992-01-01

    The nuclear industry, like the rest of modern American business, is beset by a confluence of economic, technological, competitive, regulatory, and political pressures. For better or worse, business schools and management consultants have leapt to the rescue, offering the most modern conveniences that they can purvey. Recent advances in the study of organizations have led to new tools for their analysis, revision, and repair. There are two complementary tools that do not impose values or injunctions in themselves. One, called the organization modeler, captures the hierarchy of purposes that organizations and their subparts carry out. Any deficiency or pathology is quickly illuminated, and requirements for repair are made clear. The second, called THOUGHTSTICKER, is used to capture the semantic content of the conversations that occur across the interactions of parts of an organization. The distinctions and vocabulary in the language of an organization, and the relations within that domain, are elicited from the participants so that all three are available for debate and refinement. The product of the applications of these modeling tools is not the resulting models but rather the enhancement of the organization as a consequence of the process of constructing them

  4. A Case Study Application Of Time Study Model In Paint ...

    African Journals Online (AJOL)

    This paper presents a case study in the development and application of a time study model in a paint manufacturing company. The organization specializes in the production of different grades of paint and paint containers. The paint production activities include; weighing of raw materials, drying of raw materials, dissolving ...

  5. Nuclear clustering - a cluster core model study

    International Nuclear Information System (INIS)

    Paul Selvi, G.; Nandhini, N.; Balasubramaniam, M.

    2015-01-01

    Nuclear clustering, similar to other clustering phenomenon in nature is a much warranted study, since it would help us in understanding the nature of binding of the nucleons inside the nucleus, closed shell behaviour when the system is highly deformed, dynamics and structure at extremes. Several models account for the clustering phenomenon of nuclei. We present in this work, a cluster core model study of nuclear clustering in light mass nuclei

  6. Prospective study of emergency presentation of abdominal tuberculosis

    Directory of Open Access Journals (Sweden)

    Akhilesh R. Mishra

    2016-08-01

    Full Text Available Background: In developing countries like India, where poverty, malnutrition and overcrowding prevail, tuberculosis continues to be one of the important causes of morbidity, mortality and loss of working man hours. Abdominal tuberculosis (TB can affect the gastrointestinal tract, the peritoneum, lymph nodes of the small bowel mesentery or the solid viscera (e.g. liver, spleen, pancreas etc Patient of abdominal Koch’s can present as those with a chronic undulating course and those with an acute or subacute abdominal catastrophe. In emergency the patient may present with various presentations like stricture causing obstruction or with perforation and require a different management from those routine such cases Aim and Objective: To study the varied presentation of patients with Abdominal Tuberculosis as acute surgical abdomen presenting in emergency setting to those with a subacute course. To evaluate the line of management whether operative or conservative, the operative details, post operative course and the final outcome of the disease. To study the incidence of HIV positivity in patients with abdominal tuberculosis. Methods and material: The study was designed as a prospective observational study conducted during a study period between June 2006 and June 2008 in a tertiary care centre in Mumbai. All patients with a clinical suspicion of abdominal tuberculosis were included in the study with confirmation on histopathological examination. Patient’s written informed valid consent was taken after explaining the nature of study. Result and Conclusion: Age group commonly affected was between 21-30 years with male predominance. Amongst the various complications of abdominal tuberculosis intestinal obstruction was the most common mainly due to stricture and less commonly due to hyperplastic ileocaecal mass. Next common complication observed was free perforation of the intestine which occurs at a site proximal to a tight stricture. All patients were

  7. The oral case presentation: toward a performance-based rhetorical model for teaching and learning

    Directory of Open Access Journals (Sweden)

    Mei Yuit Chan

    2015-07-01

    Full Text Available The oral case presentation is an important communicative activity in the teaching and assessment of students. Despite its importance, not much attention has been paid to providing support for teachers to teach this difficult task to medical students who are novices to this form of communication. As a formalized piece of talk that takes a regularized form and used for a specific communicative goal, the case presentation is regarded as a rhetorical activity and awareness of its rhetorical and linguistic characteristics should be given due consideration in teaching. This paper reviews practitioners’ and the limited research literature that relates to expectations of medical educators about what makes a good case presentation, and explains the rhetorical aspect of the activity. It is found there is currently a lack of a comprehensive model of the case presentation that projects the rhetorical and linguistic skills needed to produce and deliver a good presentation. Attempts to describe the structure of the case presentation have used predominantly opinion-based methodologies. In this paper, I argue for a performance-based model that would not only allow a description of the rhetorical structure of the oral case presentation, but also enable a systematic examination of the tacit genre knowledge that differentiates the expert from the novice. Such a model will be a useful resource for medical educators to provide more structured feedback and teaching support to medical students in learning this important genre.

  8. The oral case presentation: toward a performance-based rhetorical model for teaching and learning

    Science.gov (United States)

    Chan, Mei Yuit

    2015-01-01

    The oral case presentation is an important communicative activity in the teaching and assessment of students. Despite its importance, not much attention has been paid to providing support for teachers to teach this difficult task to medical students who are novices to this form of communication. As a formalized piece of talk that takes a regularized form and used for a specific communicative goal, the case presentation is regarded as a rhetorical activity and awareness of its rhetorical and linguistic characteristics should be given due consideration in teaching. This paper reviews practitioners’ and the limited research literature that relates to expectations of medical educators about what makes a good case presentation, and explains the rhetorical aspect of the activity. It is found there is currently a lack of a comprehensive model of the case presentation that projects the rhetorical and linguistic skills needed to produce and deliver a good presentation. Attempts to describe the structure of the case presentation have used predominantly opinion-based methodologies. In this paper, I argue for a performance-based model that would not only allow a description of the rhetorical structure of the oral case presentation, but also enable a systematic examination of the tacit genre knowledge that differentiates the expert from the novice. Such a model will be a useful resource for medical educators to provide more structured feedback and teaching support to medical students in learning this important genre. PMID:26194482

  9. HYDROGEOLOGIC CASE STUDIE(PRESENTATION FOR MNA WORKSHOP)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  10. Proceedings of standard model at the energy of present and future accelerators

    International Nuclear Information System (INIS)

    Csikor, F.; Pocsik, G.; Toth, E.

    1992-01-01

    This book contains the proceedings of the Workshop on The Standard Model at the Energy of the Present and Future Accelerators, 27 June - 1 July 1989, Budapest. The Standard Model of strong and electro-weak interactions providing essential insights into the fundamental structure of matter and being the basic building block of further generalizations has a rich content. The Workshop was devoted to discussing topical problems of testing the Standard Model in high energy reactions such as jet physics and fragmentation, new applications and tests of perturbative QCD, CP-violation, B-meson physics and developments in weak decays, some of the future experimental plans and related topics

  11. Mobile Applications in Cell Biology Present New Approaches for Cell Modelling

    Science.gov (United States)

    de Oliveira, Mayara Lustosa; Galembeck, Eduardo

    2016-01-01

    Cell biology apps were surveyed in order to identify whether there are new approaches for modelling cells allowed by the new technologies implemented in tablets and smartphones. A total of 97 apps were identified in 3 stores surveyed (Apple, Google Play and Amazon), they are presented as: education 48.4%, games 26.8% and medicine 15.4%. The apps…

  12. Present status on atomic and molecular data relevant to fusion plasma diagnostics and modeling

    International Nuclear Information System (INIS)

    Tawara, H.

    1997-01-01

    This issue is the collection of the paper presented status on atomic and molecular data relevant to fusion plasma diagnostics and modeling. The 10 of the presented papers are indexed individually. (J.P.N.)

  13. Hydrological catchment modelling: past, present and future

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available This paper discusses basic issues in hydrological modelling and flood forecasting, ranging from the roles of physically-based and data-driven rainfall runoff models, to the concepts of predictive uncertainty and equifinality and their implications. The evolution of a wide range of hydrological catchment models employing the physically meaningful and data-driven approaches introduces the need for objective test beds or benchmarks to assess the merits of the different models in reconciling the alternative approaches. In addition, the paper analyses uncertainty in models and predictions by clarifying the meaning of uncertainty, by distinguishing between parameter and predictive uncertainty and by demonstrating how the concept of equifinality must be addressed by appropriate and robust inference approaches. Finally, the importance of predictive uncertainty in the decision making process is highlighted together with possible approaches aimed at overcoming the diffidence of end-users.

  14. On the complementary presentation of results of risk studies

    International Nuclear Information System (INIS)

    Ehrhardt, J.; Bayer, A.

    1983-01-01

    The presentation of the loss of years of life provides the opportunity to illustrate in complementary way the mortality risks evaluated as part of risk studies. As phase A of the DRS (German risk study nuclear power plants) bears upon the results of the American ''Reactor Safety Study'' (WASH 1400) it does not contain that factor of failure which has only been determined in subsequent studies. Phase B intends to present the results of risk assessments increasingly in form of abridged lifetime. (orig.) [de

  15. Computerised modelling for developmental biology : an exploration with case studies

    NARCIS (Netherlands)

    Bertens, Laura M.F.

    2012-01-01

    Many studies in developmental biology rely on the construction and analysis of models. This research presents a broad view of modelling approaches for developmental biology, with a focus on computational methods. An overview of modelling techniques is given, followed by several case studies. Using

  16. Mathematical Modelling Research in Turkey: A Content Analysis Study

    Science.gov (United States)

    Çelik, H. Coskun

    2017-01-01

    The aim of the present study was to examine the mathematical modelling studies done between 2004 and 2015 in Turkey and to reveal their tendencies. Forty-nine studies were selected using purposeful sampling based on the term, "mathematical modelling" with Higher Education Academic Search Engine. They were analyzed with content analysis.…

  17. A mixed model framework for teratology studies.

    Science.gov (United States)

    Braeken, Johan; Tuerlinckx, Francis

    2009-10-01

    A mixed model framework is presented to model the characteristic multivariate binary anomaly data as provided in some teratology studies. The key features of the model are the incorporation of covariate effects, a flexible random effects distribution by means of a finite mixture, and the application of copula functions to better account for the relation structure of the anomalies. The framework is motivated by data of the Boston Anticonvulsant Teratogenesis study and offers an integrated approach to investigate substantive questions, concerning general and anomaly-specific exposure effects of covariates, interrelations between anomalies, and objective diagnostic measurement.

  18. Creys-Malville nuclear plant. Simulation of the cold plenum thermal-hydraulics. 12 zone model presentation

    International Nuclear Information System (INIS)

    Faulot, J.P.

    1990-05-01

    The CRUSIFI code has been developed by SEPTEN (Engineering and Construction Division) with SICLE software during 1983-1985 in order to study the CREYS-MALVILLE dynamic behavior. At the time, the version was based on project data (version 2.3). It includes a 2 zones model for the cold plenum thermal-hydraulics, modelling which does not allow to reproduce accurately dissymetries apt to occur as well in usual operating (hydraulic dissymetries bound to one or many systems out of order), as during incidentally operating (hydraulic dissymetries bound to primary pump working back or thermal dissymetries after a transient on one or many secondary loops). Moreover, a 2 zones model cannot simulate axial temperature gradients which appear during double stratification phenomenon (upper and lower part of the plenum) produced by alternating thermal shock. A 12 zones model (4 sectors with 3 axial zones each) such as model developed by R$DD (Research and Development Division) allows to satisfy correctly these problems. This report is a specification of the chosen modelling. This model is now operational after qualifying with experimental transients on mockup and reactor. It is to-day connected with the EDF general operating code CRUSIFI (calibrating version 3.0). It could be easily integrated in a four loops plant modelling such as the CREYS-MALVILLE simulator in a four loops plant modelling such as the CREYS-MALVILLE simulator under construction at the present time by THOMSON

  19. OpenDolphin: presentation models for compelling user interfaces

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    Shared applications run on the server. They still need a display, though, be it on the web or on the desktop. OpenDolphin introduces a shared presentation model to clearly differentiate between "what" to display and "how" to display. The "what" is managed on the server and is independent of the UI technology whereas the "how" can fully exploit the UI capabilities like the ubiquity of the web or the power of the desktop in terms of interactivity, animations, effects, 3D worlds, and local devices. If you run a server-centric architecture and still seek to provide the best possible user experience, then this talk is for you. About the speaker Dierk König (JavaOne Rock Star) works as a fellow for Canoo Engineering AG, Basel, Switzerland. He is a committer to many open-source projects including OpenDolphin, Groovy, Grails, GPars and GroovyFX. He is lead author of the "Groovy in Action" book, which is among ...

  20. Salt intrusion study in Cochin estuary - Using empirical models

    Digital Repository Service at National Institute of Oceanography (India)

    Jacob, B.; Revichandran, C.; NaveenKumar, K.R.

    been applied to the Cochin estuary in the present study to identify the most suitable model for predicting the salt intrusion length. Comparison of the obtained results indicate that the model of Van der Burgh (1972) is the most suitable empirical model...

  1. QUALITY OF AN ACADEMIC STUDY PROGRAMME - EVALUATION MODEL

    Directory of Open Access Journals (Sweden)

    Mirna Macur

    2016-01-01

    Full Text Available Quality of an academic study programme is evaluated by many: employees (internal evaluation and by external evaluators: experts, agencies and organisations. Internal and external evaluation of an academic programme follow written structure that resembles on one of the quality models. We believe the quality models (mostly derived from EFQM excellence model don’t fit very well into non-profit activities, policies and programmes, because they are much more complex than environment, from which quality models derive from (for example assembly line. Quality of an academic study programme is very complex and understood differently by various stakeholders, so we present dimensional evaluation in the article. Dimensional evaluation, as opposed to component and holistic evaluation, is a form of analytical evaluation in which the quality of value of the evaluand is determined by looking at its performance on multiple dimensions of merit or evaluation criteria. First stakeholders of a study programme and their views, expectations and interests are presented, followed by evaluation criteria. They are both joined into the evaluation model revealing which evaluation criteria can and should be evaluated by which stakeholder. Main research questions are posed and research method for each dimension listed.

  2. PRESENT STATUS OF RESEARCH IN DEBRIS FLOW MODELING.

    Science.gov (United States)

    Chen, Cheng-lung

    1985-01-01

    A viable rheological model should consist of both a time-independent part and a time-dependent part. A generalized viscoplastic fluid model that has both parts as well as two major rheological properties (i. e. , the normal stress effect and soil yield criteria) is shown to be sufficiently accurate, yet practical, for general use in debris flow modeling. Other rheological models, such as the Bingham plastic fluid model and the so-called Coulomb-viscous model, are compared in terms of the generalized viscoplastic fluid model.

  3. Cloud-based Monte Carlo modelling of BSSRDF for the rendering of human skin appearance (Conference Presentation)

    Science.gov (United States)

    Doronin, Alexander; Rushmeier, Holly E.; Meglinski, Igor; Bykov, Alexander V.

    2016-03-01

    We present a new Monte Carlo based approach for the modelling of Bidirectional Scattering-Surface Reflectance Distribution Function (BSSRDF) for accurate rendering of human skin appearance. The variations of both skin tissues structure and the major chromophores are taken into account correspondingly to the different ethnic and age groups. The computational solution utilizes HTML5, accelerated by the graphics processing units (GPUs), and therefore is convenient for the practical use at the most of modern computer-based devices and operating systems. The results of imitation of human skin reflectance spectra, corresponding skin colours and examples of 3D faces rendering are presented and compared with the results of phantom studies.

  4. Modelling and Analysis of Smart Grid: A Stochastic Model Checking Case Study

    DEFF Research Database (Denmark)

    Yuksel, Ender; Zhu, Huibiao; Nielson, Hanne Riis

    2012-01-01

    that require novel methods and applications. In this context, an important issue is the verification of certain quantitative properties of the system. In this paper, we consider a specific Chinese Smart Grid implementation as a case study and address the verification problem for performance and energy......Cyber-physical systems integrate information and communication technology functions to the physical elements of a system for monitoring and controlling purposes. The conversion of traditional power grid into a smart grid, a fundamental example of a cyber-physical system, raises a number of issues...... consumption. We employ stochastic model checking approach and present our modelling and analysis study using PRISM model checker....

  5. Present-Day Mars' Seismicity Predicted From 3-D Thermal Evolution Models of Interior Dynamics

    Science.gov (United States)

    Plesa, A.-C.; Knapmeyer, M.; Golombek, M. P.; Breuer, D.; Grott, M.; Kawamura, T.; Lognonné, P.; Tosi, N.; Weber, R. C.

    2018-03-01

    The Interior Exploration using Seismic Investigations, Geodesy and Heat Transport mission, to be launched in 2018, will perform a comprehensive geophysical investigation of Mars in situ. The Seismic Experiment for Interior Structure package aims to detect global and regional seismic events and in turn offer constraints on core size, crustal thickness, and core, mantle, and crustal composition. In this study, we estimate the present-day amount and distribution of seismicity using 3-D numerical thermal evolution models of Mars, taking into account contributions from convective stresses as well as from stresses associated with cooling and planetary contraction. Defining the seismogenic lithosphere by an isotherm and assuming two end-member cases of 573 K and the 1073 K, we determine the seismogenic lithosphere thickness. Assuming a seismic efficiency between 0.025 and 1, this thickness is used to estimate the total annual seismic moment budget, and our models show values between 5.7 × 1016 and 3.9 × 1019 Nm.

  6. Lake Michigan lake trout PCB model forecast post audit (oral presentation)

    Science.gov (United States)

    Scenario forecasts for total PCBs in Lake Michigan (LM) lake trout were conducted using the linked LM2-Toxics and LM Food Chain models, supported by a suite of additional LM models. Efforts were conducted under the Lake Michigan Mass Balance Study and the post audit represents an...

  7. Present status of CP violation

    International Nuclear Information System (INIS)

    Ng, J.N.

    1989-06-01

    A review of the status of CP violation in kaons is given. Status of our knowledge of quark mixing angles in the standard six quark model is presented. The role Β d o - Βd o transition plays in this study is examined. A comparison of the estimates of CP violation effects from models beyond the standard one is given. Other experiments that have the capability of testing different CP violation models are also discussed. (Author) 35 refs., 6 figs., tab

  8. Presenting Thin Media Models Affects Women's Choice of Diet or Normal Snacks

    Science.gov (United States)

    Krahe, Barbara; Krause, Christina

    2010-01-01

    Our study explored the influence of thin- versus normal-size media models and of self-reported restrained eating behavior on women's observed snacking behavior. Fifty female undergraduates saw a set of advertisements for beauty products showing either thin or computer-altered normal-size female models, allegedly as part of a study on effective…

  9. Mining Product Data Models: A Case Study

    Directory of Open Access Journals (Sweden)

    Cristina-Claudia DOLEAN

    2014-01-01

    Full Text Available This paper presents two case studies used to prove the validity of some data-flow mining algorithms. We proposed the data-flow mining algorithms because most part of mining algorithms focuses on the control-flow perspective. First case study uses event logs generated by an ERP system (Navision after we set several trackers on the data elements needed in the process analyzed; while the second case study uses the event logs generated by YAWL system. We offered a general solution of data-flow model extraction from different data sources. In order to apply the data-flow mining algorithms the event logs must comply a certain format (using InputOutput extension. But to respect this format, a set of conversion tools is needed. We depicted the conversion tools used and how we got the data-flow models. Moreover, the data-flow model is compared to the control-flow model.

  10. Average Costs versus Net Present Value

    NARCIS (Netherlands)

    E.A. van der Laan (Erwin); R.H. Teunter (Ruud)

    2000-01-01

    textabstractWhile the net present value (NPV) approach is widely accepted as the right framework for studying production and inventory control systems, average cost (AC) models are more widely used. For the well known EOQ model it can be verified that (under certain conditions) the AC approach gives

  11. Insight into runoff characteristics using hydrological modeling in the data-scarce southern Tibetan Plateau: Past, present, and future.

    Directory of Open Access Journals (Sweden)

    Mingyong Cai

    Full Text Available Regional hydrological modeling in ungauged regions has attracted growing attention in water resources research. The southern Tibetan Plateau often suffers from data scarcity in watershed hydrological simulation and water resources assessment. This hinders further research characterizing the water cycle and solving international water resource issues in the area. In this study, a multi-spatial data based Distributed Time-Variant Gain Model (MS-DTVGM is applied to the Yarlung Zangbo River basin, an important international river basin in the southern Tibetan Plateau with limited meteorological data. This model is driven purely by spatial data from multiple sources and is independent of traditional meteorological data. Based on the methods presented in this study, daily snow cover and potential evapotranspiration data in the Yarlung Zangbo River basin in 2050 are obtained. Future (2050 climatic data (precipitation and air temperature from the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR5 are used to study the hydrological response to climate change. The result shows that river runoff will increase due to precipitation and air temperature changes by 2050. Few differences are found between daily runoff simulations from different Representative Concentration Pathway (RCP scenarios (RCP2.6, RCP4.5 and RCP8.5 for 2050. Historical station observations (1960-2000 at Nuxia and model simulations for two periods (2006-2009 and 2050 are combined to study inter-annual and intra-annual runoff distribution and variability. The inter-annual runoff variation is stable and the coefficient of variation (CV varies from 0.21 to 0.27. In contrast, the intra-annual runoff varies significantly with runoff in summer and autumn accounting for more than 80% of the total amount. Compared to the historical period (1960-2000, the present period (2006-2009 has a slightly uneven intra-annual runoff temporal distribution, and becomes more

  12. Insight into runoff characteristics using hydrological modeling in the data-scarce southern Tibetan Plateau: Past, present, and future.

    Science.gov (United States)

    Cai, Mingyong; Yang, Shengtian; Zhao, Changsen; Zhou, Qiuwen; Hou, Lipeng

    2017-01-01

    Regional hydrological modeling in ungauged regions has attracted growing attention in water resources research. The southern Tibetan Plateau often suffers from data scarcity in watershed hydrological simulation and water resources assessment. This hinders further research characterizing the water cycle and solving international water resource issues in the area. In this study, a multi-spatial data based Distributed Time-Variant Gain Model (MS-DTVGM) is applied to the Yarlung Zangbo River basin, an important international river basin in the southern Tibetan Plateau with limited meteorological data. This model is driven purely by spatial data from multiple sources and is independent of traditional meteorological data. Based on the methods presented in this study, daily snow cover and potential evapotranspiration data in the Yarlung Zangbo River basin in 2050 are obtained. Future (2050) climatic data (precipitation and air temperature) from the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR5) are used to study the hydrological response to climate change. The result shows that river runoff will increase due to precipitation and air temperature changes by 2050. Few differences are found between daily runoff simulations from different Representative Concentration Pathway (RCP) scenarios (RCP2.6, RCP4.5 and RCP8.5) for 2050. Historical station observations (1960-2000) at Nuxia and model simulations for two periods (2006-2009 and 2050) are combined to study inter-annual and intra-annual runoff distribution and variability. The inter-annual runoff variation is stable and the coefficient of variation (CV) varies from 0.21 to 0.27. In contrast, the intra-annual runoff varies significantly with runoff in summer and autumn accounting for more than 80% of the total amount. Compared to the historical period (1960-2000), the present period (2006-2009) has a slightly uneven intra-annual runoff temporal distribution, and becomes more balanced in

  13. Pancreatic ductal adenocarcinoma presenting with acute and chronic pancreatitis as initial presentation: is prognosis better? A comparison study..

    Science.gov (United States)

    Thorat, Ashok; Huang, Wen-Hsuan; Yeh, Ta-Sen; Jan, Yi-Yan; Hwang, Tsann-Long

    2014-10-01

    Pancreatic ductal adenocarcinoma (PDAC) may present with acute and /or chronic pancreatitis due to pancreatic ductal obstruction causing diagnostic dilemma. The aim of this retrospective study was to investigate the outcome and prognosis of the patients of PDAC presenting with pancreatitis. From 1991 to 2009, 298 patients with PDAC that underwent surgical treatment were retrospectively studied and divided in two groups depending upon initial symptomatic presentation. Group A (n=254) comprised patients without pancreatitis while group B (n=44) patients presented with acute and/or chronic pancreatitis initially. All the patients in studied cohort were surgically treated. Mean age of group A was 63.1 years & for group B it was 62.9 years. Location of tumor was in head of the pancreas in 66.14% of group A patients (n=168) and 61.36% of group B patients (n=27). Although statistically insignificant, the patients in group B had overall better 5-year survival than the patients in group A (20% vs 15.9%). This retrospective study highlights the overall better survival of PDAC patients presenting with acute and/or chronic pancreatitis than those without as contrary to previous reports which stated the poor prognosis of PDAC patients if associated with underlying pancreatitis.

  14. Mixed models in cerebral ischemia study

    Directory of Open Access Journals (Sweden)

    Matheus Henrique Dal Molin Ribeiro

    2016-06-01

    Full Text Available The data modeling from longitudinal studies stands out in the current scientific scenario, especially in the areas of health and biological sciences, which induces a correlation between measurements for the same observed unit. Thus, the modeling of the intra-individual dependency is required through the choice of a covariance structure that is able to receive and accommodate the sample variability. However, the lack of methodology for correlated data analysis may result in an increased occurrence of type I or type II errors and underestimate/overestimate the standard errors of the model estimates. In the present study, a Gaussian mixed model was adopted for the variable response latency of an experiment investigating the memory deficits in animals subjected to cerebral ischemia when treated with fish oil (FO. The model parameters estimation was based on maximum likelihood methods. Based on the restricted likelihood ratio test and information criteria, the autoregressive covariance matrix was adopted for errors. The diagnostic analyses for the model were satisfactory, since basic assumptions and results obtained corroborate with biological evidence; that is, the effectiveness of the FO treatment to alleviate the cognitive effects caused by cerebral ischemia was found.

  15. Differential levels of brain amino acids in rat models presenting learned helplessness or non-learned helplessness.

    Science.gov (United States)

    Muneoka, Katsumasa; Shirayama, Yukihiko; Horio, Mao; Iyo, Masaomi; Hashimoto, Kenji

    2013-09-01

    Glutamatergic and γ-aminobutyric acid (GABA)ergic abnormalities have recently been proposed to contribute to depression. The learned helplessness (LH) paradigm produces a reliable animal model of depression that expresses a deficit in escape behavior (LH model); an alternative phenotype that does not exhibit LH is a model of resilience to depression (non-LH model). We measured the contents of amino acids in the brain to investigate the mechanisms involved in the pathology of depression. LH and non-LH models were subjected to inescapable electric footshocks at random intervals following a conditioned avoidance test to determine acquirement of predicted escape deficits. Tissue amino acid contents in eight brain regions were measured via high-performance liquid chromatography. The non-LH model showed increased GABA levels in the dentate gyrus and nucleus accumbens and increased glutamine levels in the dentate gyrus and the orbitofrontal cortex. The LH model had reduced glutamine levels in the medial prefrontal cortex. Changes in the ratios of GABA, glutamine, and glutamate were detected in the non-LH model, but not in the LH model. Reductions in threonine levels occurred in the medial prefrontal cortex in both models, whereas elevated alanine levels were detected in the medial prefrontal cortex in non-LH animals. The present study demonstrates region-specific compensatory elevations in GABA levels in the dentate gyrus and nucleus accumbens of non-LH animals, supporting the implication of the GABAergic system in the recovery of depression.

  16. High-Level Waste Glass Formulation Model Sensitivity Study 2009 Glass Formulation Model Versus 1996 Glass Formulation Model

    International Nuclear Information System (INIS)

    Belsher, J.D.; Meinert, F.L.

    2009-01-01

    This document presents the differences between two HLW glass formulation models (GFM): The 1996 GFM and 2009 GFM. A glass formulation model is a collection of glass property correlations and associated limits, as well as model validity and solubility constraints; it uses the pretreated HLW feed composition to predict the amount and composition of glass forming additives necessary to produce acceptable HLW glass. The 2009 GFM presented in this report was constructed as a nonlinear optimization calculation based on updated glass property data and solubility limits described in PNNL-18501 (2009). Key mission drivers such as the total mass of HLW glass and waste oxide loading are compared between the two glass formulation models. In addition, a sensitivity study was performed within the 2009 GFM to determine the effect of relaxing various constraints on the predicted mass of the HLW glass.

  17. Past, Present, and Future Anthropogenic Emissions over Asia: a Regional Air Quality Modeling Perspective

    Science.gov (United States)

    Woo, Jung-Hun; Jung, Bujeon; Choi, Ki-Chul; Seo, Ji-Hyun; Kim, Tae Hyung; Park, Rokjin J.; Youn, Daeok; Jeong, Jaein; Moon, Byung-Kwon; Yeh, Sang-Wook

    2010-05-01

    Climate change will also affect future regional air quality which has potential human health, ecosystem, and economic implications. To analyze the impacts of climate change on Asian air quality, the NIER (National Institute of Environmental Research, Korea) integrated modeling framework was developed based on global-to-regional climate and atmospheric chemistry models. In this study, we developed emission inventories for the modeling framework for 1980~2100 with an emphasis on Asia emissions. Two emission processing systems which have functions of emission projection, spatial/temporal allocation, and chemical speciation have been also developed in support of atmospheric chemistry models including GEOS-Chem and Models-3/CMAQ. Asia-based emission estimates, projection factors, temporal allocation parameters were combined to improve regional modeling capability of past, present and future air quality over Asia. The global CO emissions show a 23% decrease from the years 1980 to 2000. For the future CO (from year 2000 to 2100), the A2 scenario shows a 95% increase due to the B40 (Residential-Biofuel) sector of Western Africa, Eastern Africa and East Asia and the F51 (Transport Road-Fossil fuel) sector of Middle East, USA and South Asia. The B1 scenario, however, shows a 79% decrease of emissions due to B40 and F51 sectors of East Asia, South Asia and USA for the same period. In many cases, Asian emissions play important roles for global emission increase or decrease depending on the IPCC scenarios considered. The regional ozone forming potential will be changed due to different VOC/NOx emission ratio changes in the future. More similarities and differences of Asian emission characteristics, in comparison with its global counterpart, are investigated.

  18. Present status of the VMI and related models

    International Nuclear Information System (INIS)

    Scharff-Goldhaber, G.

    1980-05-01

    This article traces the evolution of the Variable Moment of Inertia model in its relation to the shell model, the Bohr-Mottelson model and the Interacting Boson Model. The discovery of a new type of spectrum, that of pseudomagic nuclei (isobars of doubly magic nuclei) is reported, and an explanation for their dynamics is suggested. The type of rotational motion underlying the ground state band of an e-e nucleus is shown to depend on whether the minimum number of valence nucleon pairs of one kind (neutrons or protons) is less than or equal to 2 or > 2. In the former case the alpha-dumbbell model holds; in the latter the two-fluid model

  19. Western Wind and Solar Integration Study Phase 2 (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Lew, D.; Brinkman, G.; Ibanez, E.; Kumar, N.; Lefton, S.; Jordan, G.; Venkataraman, S.; King, J.

    2013-06-01

    This presentation accompanies Phase 2 of the Western Wind and Solar Integration Study, a follow-on to Phase 1, which examined the operational impacts of high penetrations of variable renewable generation on the electric power system in the West and was one of the largest variable generation studies to date. High penetrations of variable generation can induce cycling of fossil-fueled generators. Cycling leads to wear-and-tear costs and changes in emissions. Phase 2 calculated these costs and emissions, and simulated grid operations for a year to investigate the detailed impact of variable generation on the fossil-fueled fleet. The presentation highlights the scope of the study and results.

  20. Hydrological Modeling in Northern Tunisia with Regional Climate Model Outputs: Performance Evaluation and Bias-Correction in Present Climate Conditions

    Directory of Open Access Journals (Sweden)

    Asma Foughali

    2015-07-01

    Full Text Available This work aims to evaluate the performance of a hydrological balance model in a watershed located in northern Tunisia (wadi Sejnane, 378 km2 in present climate conditions using input variables provided by four regional climate models. A modified version (MBBH of the lumped and single layer surface model BBH (Bucket with Bottom Hole model, in which pedo-transfer parameters estimated using watershed physiographic characteristics are introduced is adopted to simulate the water balance components. Only two parameters representing respectively the water retention capacity of the soil and the vegetation resistance to evapotranspiration are calibrated using rainfall-runoff data. The evaluation criterions for the MBBH model calibration are: relative bias, mean square error and the ratio of mean actual evapotranspiration to mean potential evapotranspiration. Daily air temperature, rainfall and runoff observations are available from 1960 to 1984. The period 1960–1971 is selected for calibration while the period 1972–1984 is chosen for validation. Air temperature and precipitation series are provided by four regional climate models (DMI, ARP, SMH and ICT from the European program ENSEMBLES, forced by two global climate models (GCM: ECHAM and ARPEGE. The regional climate model outputs (precipitation and air temperature are compared to the observations in terms of statistical distribution. The analysis was performed at the seasonal scale for precipitation. We found out that RCM precipitation must be corrected before being introduced as MBBH inputs. Thus, a non-parametric quantile-quantile bias correction method together with a dry day correction is employed. Finally, simulated runoff generated using corrected precipitation from the regional climate model SMH is found the most acceptable by comparison with runoff simulated using observed precipitation data, to reproduce the temporal variability of mean monthly runoff. The SMH model is the most accurate to

  1. Linear regression metamodeling as a tool to summarize and present simulation model results.

    Science.gov (United States)

    Jalal, Hawre; Dowd, Bryan; Sainfort, François; Kuntz, Karen M

    2013-10-01

    Modelers lack a tool to systematically and clearly present complex model results, including those from sensitivity analyses. The objective was to propose linear regression metamodeling as a tool to increase transparency of decision analytic models and better communicate their results. We used a simplified cancer cure model to demonstrate our approach. The model computed the lifetime cost and benefit of 3 treatment options for cancer patients. We simulated 10,000 cohorts in a probabilistic sensitivity analysis (PSA) and regressed the model outcomes on the standardized input parameter values in a set of regression analyses. We used the regression coefficients to describe measures of sensitivity analyses, including threshold and parameter sensitivity analyses. We also compared the results of the PSA to deterministic full-factorial and one-factor-at-a-time designs. The regression intercept represented the estimated base-case outcome, and the other coefficients described the relative parameter uncertainty in the model. We defined simple relationships that compute the average and incremental net benefit of each intervention. Metamodeling produced outputs similar to traditional deterministic 1-way or 2-way sensitivity analyses but was more reliable since it used all parameter values. Linear regression metamodeling is a simple, yet powerful, tool that can assist modelers in communicating model characteristics and sensitivity analyses.

  2. Air Pollution Exposure Modeling for Health Studies | Science ...

    Science.gov (United States)

    Dr. Michael Breen is leading the development of air pollution exposure models, integrated with novel personal sensor technologies, to improve exposure and risk assessments for individuals in health studies. He is co-investigator for multiple health studies assessing the exposure and effects of air pollutants. These health studies include participants with asthma, diabetes, and coronary artery disease living in various U.S. cities. He has developed, evaluated, and applied novel exposure modeling and time-activity tools, which includes the Exposure Model for Individuals (EMI), GPS-based Microenvironment Tracker (MicroTrac) and Exposure Tracker models. At this seminar, Dr. Breen will present the development and application of these models to predict individual-level personal exposures to particulate matter (PM) for two health studies in central North Carolina. These health studies examine the association between PM and adverse health outcomes for susceptible individuals. During Dr. Breen’s visit, he will also have the opportunity to establish additional collaborations with researchers at Harvard University that may benefit from the use of exposure models for cohort health studies. These research projects that link air pollution exposure with adverse health outcomes benefit EPA by developing model-predicted exposure-dose metrics for individuals in health studies to improve the understanding of exposure-response behavior of air pollutants, and to reduce participant

  3. Comparative study between a QCD inspired model and a multiple diffraction model

    International Nuclear Information System (INIS)

    Luna, E.G.S.; Martini, A.F.; Menon, M.J.

    2003-01-01

    A comparative study between a QCD Inspired Model (QCDIM) and a Multiple Diffraction Model (MDM) is presented, with focus on the results for pp differential cross section at √s = 52.8 GeV. It is shown that the MDM predictions are in agreement with experimental data, except for the dip region and that the QCDIM describes only the diffraction peak region. Interpretations in terms of the corresponding eikonals are also discussed. (author)

  4. In vitro three-dimensional cancer metastasis modeling: Past, present, and future

    International Nuclear Information System (INIS)

    Han Wei-jing; Zhu Jiang-rui; Fan Qihui; Liu Li-yu; Yuan Wei; Qu Junle

    2016-01-01

    Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our understanding of the progression of malignancy. However, most of the molecular mechanisms fail to address the causes of cancer and its evolutionary origin, demonstrating an inability to find a solution for complete cure of cancer. After being a neglected area of tumor biology for quite some time, recently several studies have focused on the impact of the tumor microenvironment on cancer growth. The importance of the tumor microenvironment is gradually gaining attention, particularly from the perspective of biophysics. In vitro three-dimensional (3-D) metastatic models are an indispensable platform for investigating the tumor microenvironment, as they mimic the in vivo tumor tissue. In 3-D metastatic in vitro models, static factors such as the mechanical properties, biochemical factors, as well as dynamic factors such as cell–cell, cell–ECM interactions, and fluid shear stress can be studied quantitatively. With increasing focus on basic cancer research and drug development, the in vitro 3-D models offer unique advantages in fundamental and clinical biomedical studies. (topical review)

  5. Presentation of a model simulating the response of lakes to fertilizations to reduce radiocesium levels in fish

    International Nuclear Information System (INIS)

    Hakanson, L.; Ottosson, F.; Abrahamsson, O.; Johansson, T.

    1998-01-01

    Lake fertilization is a potential remedy for toxic contamination in lakes with low productivity, which are known to be sensitive to, e.g. radionuclides, metals and organic toxins. This study presents a model to plan the duration and predict the outcome of fertilization in lakes. Several methods of lake fertilization have been used in field experiments: (1) Lake and wetland liming using 'mixed' lime with added phosphorus; (2) treatment with commercial fertilizers; and (3) using effluents (containing phosphorus) from fish farms. This model is basically a dynamic model using differential equations to handle fluxes, amounts and concentrations. It also includes several empirical relationships, because the model is meant to be used in practice and the driving variables should be few and readily available, like catchment and lake morphometric data. The model is primarily intended to be used as a sub-model predicting realistic changes in phosphorus and potassium concentrations and in lake pH caused by these remedial measures within the framework of a more extensive lake model for radiocesium. It is, however, meant to be based on the fundamental processes regulating phosphorus fluxes in lakes, and could be of interest also in contexts other than radioecology. It is driven by the amount of fertilizer added to the lake and the month of treatment. The consequences for the spread, biological uptake and concentrations of radiocesium are also discussed and simulated. The phosphorus model is, and must be, easy to handle since all the input data should be derived either from maps or from regular monitoring programs. In this paper, the model is presented and calibrations are examined. The results of the calibrations indicate that the model should be useful for managers to optimise lake fertilization, e.g. in contexts of lake radioecology where the benefits and drawbacks of different remedial strategies are evaluated (multi-attribute analysis). (Copyright (c) 1998 Elsevier Science B

  6. Mathematical study of mixing models

    International Nuclear Information System (INIS)

    Lagoutiere, F.; Despres, B.

    1999-01-01

    This report presents the construction and the study of a class of models that describe the behavior of compressible and non-reactive Eulerian fluid mixtures. Mixture models can have two different applications. Either they are used to describe physical mixtures, in the case of a true zone of extensive mixing (but then this modelization is incomplete and must be considered only as a point of departure for the elaboration of models of mixtures actually relevant). Either they are used to solve the problem of the numerical mixture. This problem appears during the discretization of an interface which separates fluids having laws of different state: the zone of numerical mixing is the set of meshes which cover the interface. The attention is focused on numerical mixtures, for which the hypothesis of non-miscibility (physics) will bring two equations (the sixth and the eighth of the system). It is important to emphasize that even in the case of the only numerical mixture, the presence in one and same place (same mesh) of several fluids have to be taken into account. This will be formalized by the possibility for mass fractions to take all values between 0 and 1. This is not at odds with the equations that derive from the hypothesis of non-miscibility. One way of looking at things is to consider that there are two scales of observation: the physical scale at which one observes the separation of fluids, and the numerical scale, given by the fineness of the mesh, to which a mixture appears. In this work, mixtures are considered from the mathematical angle (both in the elaboration phase and during their study). In particular, Chapter 5 shows a result of model degeneration for a non-extended mixing zone (case of an interface): this justifies the use of models in the case of numerical mixing. All these models are based on the classical model of non-viscous compressible fluids recalled in Chapter 2. In Chapter 3, the central point of the elaboration of the class of models is

  7. Model study on radioecology in Biblis. Pt. 2

    Energy Technology Data Exchange (ETDEWEB)

    1980-03-01

    The present volume 'Water Pathway II' of the model study radioecology Biblis contains the remaining six part studies on the subjects: 1. Concentration of radionuclides in river sediments. 2. Incorporation via terrestrial food (milk, fruit, vegetables). 3. Radioactive substances in the Rhine not arising from nuclear power stations. 4. Dynamic model for intermittent outlet during reactor operation. 5. Exposure to radiation of the Rhine-fishes. 6. Influence of contaminated waste water on industrial utilization of surface waters.

  8. Overhead distribution line models for harmonics studies

    Energy Technology Data Exchange (ETDEWEB)

    Nagpal, M.; Xu, W.; Dommel, H.W.

    1994-01-01

    Carson's formulae and Maxwell's potential coefficients are used for calculating the per unit length series impedances and shunt capacitances of the overhead lines. The per unit length values are then used for building the models, nominal pi-circuit, and equivalent pi-circuit at the harmonic frequencies. This paper studies the accuracy of these models for presenting the overhead distribution lines in steady-state harmonic solutions at frequencies up to 5 kHz. The models are verified with a field test on a 25 kV distribution line and the sensitivity of the models to ground resistivity, skin effect, and multiple grounding is reported.

  9. Geothermal Exploration Case Studies on OpenEI (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Young, K.; Bennett, M.; Atkins, D.

    2014-03-01

    The U.S. Geological Survey (USGS) resource assessment (Williams et al., 2008) outlined a mean 30 GWe of undiscovered hydrothermal resource in the western United States. One goal of the U.S. Department of Energy's (DOE) Geothermal Technology Office (GTO) is to accelerate the development of this undiscovered resource. DOE has focused efforts on helping industry identify hidden geothermal resources to increase geothermal capacity in the near term. Increased exploration activity will produce more prospects, more discoveries, and more readily developable resources. Detailed exploration case studies akin to those found in oil and gas (e.g. Beaumont and Foster, 1990-1992) will give developers central location for information gives models for identifying new geothermal areas, and guide efficient exploration and development of these areas. To support this effort, the National Renewable Energy Laboratory (NREL) has been working with GTO to develop a template for geothermal case studies on the Geothermal Gateway on OpenEI. In 2012, the template was developed and tested with two case studies: Raft River Geothermal Area (http://en.openei.org/wiki/Raft_River_Geothermal_Area) and Coso Geothermal Area (http://en.openei.org/wiki/Coso_Geothermal_Area). In 2013, ten additional case studies were completed, and Semantic MediaWiki features were developed to allow for more data and the direct citations of these data. These case studies are now in the process of external peer review. In 2014, NREL is working with universities and industry partners to populate additional case studies on OpenEI. The goal is to provide a large enough data set to start conducting analyses of exploration programs to identify correlations between successful exploration plans for areas with similar geologic occurrence models.

  10. A model for voltage collapse study considering load characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Aguiar, L B [Companhia de Energia Eletrica da Bahia (COELBA), Salvador, BA (Brazil)

    1994-12-31

    This paper presents a model for analysis of voltage collapse and instability problem considering the load characteristics. The model considers fundamentally the transmission lines represented by exact from through the generalized constants A, B, C, D and the loads as function of the voltage, emphasizing the cases of constant power, constant current and constant impedance. the study treats of the system behavior on steady state and presents illustrative graphics about the problem. (author) 12 refs., 4 figs.

  11. On the Present State of Information Society Studies.

    Science.gov (United States)

    Duff, Alistair S.

    2001-01-01

    Assesses the present condition of the emerging specialism of information society studies. Topics include the information economy; information technology; the information explosion; the Japanese version of information society; information society as social democracy; sociology and information science; scholarly journals; and the need for…

  12. Present and future ecological niche modeling of garter snake species from the Trans-Mexican Volcanic Belt

    Science.gov (United States)

    García-Vázquez, Uri; D’Addario, Maristella

    2018-01-01

    Land use and climate change are affecting the abundance and distribution of species. The Trans-Mexican Volcanic Belt (TMVB) is a very diverse region due to geological history, geographic position, and climate. It is also one of the most disturbed regions in Mexico. Reptiles are particularly sensitive to environmental changes due to their low dispersal capacity and thermal ecology. In this study, we define the important environmental variables (considering climate, topography, and land use) and potential distribution (present and future) of the five Thamnophis species present in TMVB. To do so, we used the maximum entropy modeling software (MAXENT). First, we modeled to select the most important variables to explain the distribution of each species, then we modeled again using only the most important variables and projected these models to the future considering a middle-moderate climate change scenario (rcp45), and land use and vegetation variables for the year 2050 (generated according to land use changes that occurred between years 2002 and 2011). Arid vegetation had an important negative effect on habitat suitability for all species, and minimum temperature of the coldest month was important for four of the five species. Thamnophis cyrtopsis was the species with the lowest tolerance to minimum temperatures. The maximum temperature of the warmest month was important for T. scalaris and T. cyrtopsis. Low percentages of agriculture were positive for T. eques and T. melanogaster but, at higher values, agriculture had a negative effect on habitat suitability for both species. Elevation was the most important variable to explain T. eques and T. melanogaster potential distribution while distance to Abies forests was the most important variable for T. scalaris and T. scaliger. All species had a high proportion of their potential distribution in the TMVB. However, according to our models, all Thamnophis species will experience reductions in their potential

  13. Fuel model studies. Comparison of our present version of GAPCON-THERMAL-2 with results from the EPRI code comparison study. Partial report

    International Nuclear Information System (INIS)

    Malen, K.; Jansson, L.

    1978-08-01

    Runs with our present version of GAPCON-THERMAL-2 have been compared to results from the EPRI code comparison study. Usually also our version of GAPCON predicts high temperatures, 100-300 K or 10-15% higher than average code predictions and experimental results. The well-known temperaturegas release instablility is found also with GAPCON. In this case one identifies the gas release limits 1400 deg C and 1700 deg C as instablility points. (author)

  14. Voting Present

    Directory of Open Access Journals (Sweden)

    James Lo

    2013-12-01

    Full Text Available During his time as a state senator in Illinois, Barack Obama voted “Present” 129 times, a deliberate act of nonvoting that subsequently became an important campaign issue during the 2008 presidential elections. In this article, I examine the use of Present votes in the Illinois state senate. I find evidence that Present votes can largely be characterized as protest votes used as a legislative tool by the minority party. Incorporating information from Present votes into a Bayesian polytomous item-response model, I find that this information increases the efficiency of ideal point estimates by approximately 35%. There is little evidence of significant moderation by Obama when Present votes are accounted for, though my results suggest that Obama’s voting record may have moderated significantly before his subsequent election to the U.S. Senate. My results also suggest that because legislative nonvoting may occur for a variety of reasons, naive inclusion of nonvoting behavior into vote choice models may lead to biased results.

  15. Modelling in Action. Examining How Students Approach Modelling Real Life Situations. Three Case Studies. Model of the Movement of an Elevator

    Science.gov (United States)

    Rivas, Eugenia Marmolejo

    2015-01-01

    By means of three case studies, we will present two mathematical modelling activities that are suitable for students enrolled in senior high school and the first year of mathematics at university level. The activities have been designed to enrich the learning process and promote the formation of vital modelling skills. In case studies one and two,…

  16. Wildland Fire Behaviour Case Studies and Fuel Models for Landscape-Scale Fire Modeling

    Directory of Open Access Journals (Sweden)

    Paul-Antoine Santoni

    2011-01-01

    Full Text Available This work presents the extension of a physical model for the spreading of surface fire at landscape scale. In previous work, the model was validated at laboratory scale for fire spreading across litters. The model was then modified to consider the structure of actual vegetation and was included in the wildland fire calculation system Forefire that allows converting the two-dimensional model of fire spread to three dimensions, taking into account spatial information. Two wildland fire behavior case studies were elaborated and used as a basis to test the simulator. Both fires were reconstructed, paying attention to the vegetation mapping, fire history, and meteorological data. The local calibration of the simulator required the development of appropriate fuel models for shrubland vegetation (maquis for use with the model of fire spread. This study showed the capabilities of the simulator during the typical drought season characterizing the Mediterranean climate when most wildfires occur.

  17. Lecture Presentations

    International Nuclear Information System (INIS)

    2007-01-01

    The Heavy-Ion Collisions in the LHC workshop held in Cracow from 18 to 18 May 2007. The main subject of the workshop was to present the newest results of research provided at CERN LHC collider. Additionally some theoretical models and methods used for presented data analysis were discussed

  18. A mathematical model of the rail track presented as a bar on elastic and dissipative supports under the influence of moving loads

    Directory of Open Access Journals (Sweden)

    Darenskiy Alexander

    2017-01-01

    Full Text Available At present, the most common track model is the one in which rails are presented as bars of infinite length rested on continuous elastic foundation. However, some specialists consider the model to be rather ideal for railways in terms of track and the technical state of track. Calculation of track as a bar rested on numerous elastic supports with variable characteristics of stiffness under static loads has shown that application of methods of elastic foundation gives results understated by 17-24%. The study presents mathematic models of the vehicle/track dynamic system, and a design scheme of track presented as a bar on numerous elastic dissipative supports with non-linear characteristics, which is taken on the base of this system. The authors developed models and methods to define the reduced vertical stiffness of the track in the wheel/rail contact point, which considers rail elastic and geometric characteristics, stiffness of supports, distance between supports and distributed track mass. The value of stiffness is variable by time for each wheel at any time and various for the vehicle’s wheels. The mathematical model proposed has been implemented in Matlab software and will make it possible to conduct numerical research into the track/vehicle dynamics.

  19. Imaging and modeling of collagen architecture in living tissue with polarized light transfer (Conference Presentation)

    Science.gov (United States)

    Ramella-Roman, Jessica C.; Stoff, Susan; Chue-Sang, Joseph; Bai, Yuqiang

    2016-03-01

    The extra-cellular space in connective tissue of animals and humans alike is comprised in large part of collagen. Monitoring of collagen arrangement and cross-linking has been utilized to diagnose a variety of medical conditions and guide surgical intervention. For example, collagen monitoring is useful in the assessment and treatment of cervical cancer, skin cancer, myocardial infarction, and non-arteritic anterior ischemic optic neuropathy. We have developed a suite of tools and models based on polarized light transfer for the assessment of collagen presence, cross-linking, and orientation in living tissue. Here we will present some example of such approach applied to the human cervix. We will illustrate a novel Mueller Matrix (MM) imaging system for the study of cervical tissue; furthermore we will show how our model of polarized light transfer through cervical tissue compares to the experimental findings. Finally we will show validation of the methodology through histological results and Second Harmonic imaging microscopy.

  20. Geology - Background complementary studies. Forsmark modelling stage 2.2

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, Michael B. [Geological Survey of Sweden, Uppsala (Sweden); Skagius, Kristina [Kemakta Konsult AB, Stockholm (Sweden)] (eds.)

    2007-09-15

    During Forsmark model stage 2.2, seven complementary geophysical and geological studies were initiated by the geological modelling team, in direct connection with and as a background support to the deterministic modelling of deformation zones. One of these studies involved a field control on the character of two low magnetic lineaments with NNE and NE trends inside the target volume. The interpretation of these lineaments formed one of the late deliveries to SKB that took place after the data freeze for model stage 2.2 and during the initial stage of the modelling work. Six studies involved a revised processing and analysis of reflection seismic, refraction seismic and selected oriented borehole radar data, all of which had been presented earlier in connection with the site investigation programme. A prime aim of all these studies was to provide a better understanding of the geological significance of indirect geophysical data to the geological modelling team. Such essential interpretative work was lacking in the material acquired in connection with the site investigation programme. The results of these background complementary studies are published together in this report. The titles and authors of the seven background complementary studies are presented below. Summaries of the results of each study, with a focus on the implications for the geological modelling of deformation zones, are presented in the master geological report, SKB-R--07-45. The sections in the master report, where reference is made to each background complementary study and where the summaries are placed, are also provided. The individual reports are listed in the order that they are referred to in the master geological report and as they appear in this report. 1. Scan line fracture mapping and magnetic susceptibility measurements across two low magnetic lineaments with NNE and NE trend, Forsmark. Jesper Petersson, Ulf B. Andersson and Johan Berglund. 2. Integrated interpretation of surface and

  1. Geology - Background complementary studies. Forsmark modelling stage 2.2

    International Nuclear Information System (INIS)

    Stephens, Michael B.; Skagius, Kristina

    2007-09-01

    During Forsmark model stage 2.2, seven complementary geophysical and geological studies were initiated by the geological modelling team, in direct connection with and as a background support to the deterministic modelling of deformation zones. One of these studies involved a field control on the character of two low magnetic lineaments with NNE and NE trends inside the target volume. The interpretation of these lineaments formed one of the late deliveries to SKB that took place after the data freeze for model stage 2.2 and during the initial stage of the modelling work. Six studies involved a revised processing and analysis of reflection seismic, refraction seismic and selected oriented borehole radar data, all of which had been presented earlier in connection with the site investigation programme. A prime aim of all these studies was to provide a better understanding of the geological significance of indirect geophysical data to the geological modelling team. Such essential interpretative work was lacking in the material acquired in connection with the site investigation programme. The results of these background complementary studies are published together in this report. The titles and authors of the seven background complementary studies are presented below. Summaries of the results of each study, with a focus on the implications for the geological modelling of deformation zones, are presented in the master geological report, SKB-R--07-45. The sections in the master report, where reference is made to each background complementary study and where the summaries are placed, are also provided. The individual reports are listed in the order that they are referred to in the master geological report and as they appear in this report. 1. Scan line fracture mapping and magnetic susceptibility measurements across two low magnetic lineaments with NNE and NE trend, Forsmark. Jesper Petersson, Ulf B. Andersson and Johan Berglund. 2. Integrated interpretation of surface and

  2. International Symposium on Isotopes in Hydrology, Marine Ecosystems, and Climate Change Studies. Presentations

    International Nuclear Information System (INIS)

    2011-01-01

    Human activities have had a far-reaching impact on the aquatic environments - both marine and freshwater systems. The protection of these systems against further deterioration and the promotion of sustainable use are vital. In order to deepen understanding about the main processes affecting the present situation, as well as possible developments in the future, further investigation is required. The oceans play a major role in climate change, for example, and ocean acidification by increased CO2 release is one major threat to the world's oceans. Isotope methods can play a critical role in identifying and quantifying key processes within aquatic environments. Addressing the problems of global water resources has become a matter of urgency. Water resources are subject to multiple pressures for various reasons, including increasing populations, climate change, rising food and energy costs, the global economic crisis and pollutant loading. Isotope hydrology provides the unique and critical tools required to address complex water problems and helps managers and policy makers understand the closely intertwined relationship between water resources and the various pressures affecting them, as well as the issue of sustainability. The symposium will be an important forum for the exchange of knowledge on the present state of marine and freshwater environments, use of isotopes in water resources investigations and management, and climate change studies. The meeting will involve leading scientists in the field of climate change and hydrology, as well as representatives from other United Nations bodies and international organizations that focus on climate change and other important environmental issues. TOPICS: The role of isotopes in understanding and modelling climate change, marine ecosystems and the water cycle; Carbon dioxide sequestration and related aspects of the carbon cycle, such as ocean acidification; Isotopes in groundwater flow modelling for large aquifers

  3. Presentation of chronic daily headache : A clinical study

    NARCIS (Netherlands)

    Spierings, E L H; Schroevers, M.; Honkoop, P.C.; Sorbi, M.

    We studied the presentation of chronic daily headache in 258 patients from a private headache practice, 50 men and 208 women. Chronic daily headache was defined as headaches, occurring at least 5 days per week for at least 1 year. Seventy-seven percent of the patients experienced the onset of

  4. Portuguese Familial Hypercholesterolemia Study: presentation of the study and preliminary results.

    Science.gov (United States)

    Bourbon, Mafalda; Rato, Quitéria

    2006-11-01

    Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder caused, in the majority of cases, by a partial or total lack of functional low density lipoprotein receptors (LDLR). Mutations in the LDLR gene lead to increased plasma cholesterol levels, resulting in cholesterol deposition in the arteries, thereby increasing the risk of premature coronary heart disease. The homozygous form of FH is rare but heterozygous FH is common, although underdiagnosed in many populations, including the Portuguese. In 1999 the Portuguese Familial Hypercholesterolemia Study was begun at the National Institute of Health. The aim of the Portuguese Familial H ypercholesterolemia Study is to perform an epidemiological study to determine the prevalence and distribution of FH in Portugal and to better understand the pathophysiology of coronary heart disease in these patients. The aim of the present work is to present the study's criteria and organization as well as its preliminary results. The study population consists of individuals of both sexes and all ages with a clinical diagnosis of FH, with biochemical and molecular characterization being performed. The clinical criteria used for the diagnosis of FH were adapted from those of the Simon Broome Heart Research Trust. The study is organized in five stages: 1. selection of individuals with a clinical diagnosis of FH; 2. completion of a clinical questionnaire and declaration of informed consent; 3. collection of blood samples; 4. biochemical characterization; 5. molecular study of three genes associated with the FH phenotype: LDLR, apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9). Between 1999 and June 2006 the LDLR gene and the APOB gene of 141 index cases (38 children and 103 adults) were studied. In 78 of these index cases (76 heterozygotes and two homozygotes) 50 different mutations in the LDLR gene were identified, and two unrelated individuals were found to have the ApoB3500 mutation

  5. Chick embryo partial ischemia model: a new approach to study ischemia ex vivo.

    Directory of Open Access Journals (Sweden)

    Syamantak Majumder

    Full Text Available BACKGROUND: Ischemia is a pathophysiological condition due to blockade in blood supply to a specific tissue thus damaging the physiological activity of the tissue. Different in vivo models are presently available to study ischemia in heart and other tissues. However, no ex vivo ischemia model has been available to date for routine ischemia research and for faster screening of anti-ischemia drugs. In the present study, we took the opportunity to develop an ex vivo model of partial ischemia using the vascular bed of 4(th day incubated chick embryo. METHODOLOGY/PRINCIPAL FINDINGS: Ischemia was created in chick embryo by ligating the right vitelline artery using sterile surgical suture. Hypoxia inducible factor- 1 alpha (HIF-1alpha, creatine phospho kinase-MB and reactive oxygen species in animal tissues and cells were measured to confirm ischemia in chick embryo. Additionally, ranolazine, N-acetyl cysteine and trimetazidine were administered as an anti-ischemic drug to validate the present model. Results from the present study depicted that blocking blood flow elevates HIF-1alpha, lipid peroxidation, peroxynitrite level in ischemic vessels while ranolazine administration partially attenuates ischemia driven HIF-1alpha expression. Endothelial cell incubated on ischemic blood vessels elucidated a higher level of HIF-1alpha expression with time while ranolazine treatment reduced HIF-1alpha in ischemic cells. Incubation of caprine heart strip on chick embryo ischemia model depicted an elevated creatine phospho kinase-MB activity under ischemic condition while histology of the treated heart sections evoked edema and disruption of myofibril structures. CONCLUSIONS/SIGNIFICANCE: The present study concluded that chick embryo partial ischemia model can be used as a novel ex vivo model of ischemia. Therefore, the present model can be used parallel with the known in vivo ischemia models in understanding the mechanistic insight of ischemia development and in

  6. Three-Dimensional Model Test Study of a CUBIPOD Armoured Roundhead

    DEFF Research Database (Denmark)

    Burcharth, Hans F.; Andersen, Thomas Lykke; Aldama, J. M. Urrutia

    ‐crested wave tests were performed as well. One objective of the tests was to compare the stability of CUBIPOD armoured roundheads to the stability of cube armoured roundheads. This could be done by choosing a model test setup identical to that previous used in a study of the stability of a cube armoured......The present report presents results from a three‐dimensional model test study carried out at Aalborg University in the period September 2008 - December 2008. The model tests were carried out to study the stability of a CUBIPOD armoured roundhead under short‐crested wave attack. Few long...... roundhead for the Punta Langosteira breakwater at La Coruna. To have a direct comparison some of the new test series were reproduced with cubes also. This was done with identical steering signals send to the paddles....

  7. Detailed kinetic modeling study of n-pentanol oxidation

    KAUST Repository

    Heufer, Karl Alexander; Sarathy, Mani; Curran, Henry J.; Davis, Alexander C.; Westbrook, Charles K.; Pitz, William J.

    2012-01-01

    To help overcome the world's dependence upon fossil fuels, suitable biofuels are promising alternatives that can be used in the transportation sector. Recent research on internal combustion engines shows that short alcoholic fuels (e.g., ethanol or n-butanol) have reduced pollutant emissions and increased knock resistance compared to fossil fuels. Although higher molecular weight alcohols (e.g., n-pentanol and n-hexanol) exhibit higher reactivity that lowers their knock resistance, they are suitable for diesel engines or advanced engine concepts, such as homogeneous charge compression ignition (HCCI), where higher reactivity at lower temperatures is necessary for engine operation. The present study presents a detailed kinetic model for n-pentanol based on modeling rules previously presented for n-butanol. This approach was initially validated using quantum chemistry calculations to verify the most stable n-pentanol conformation and to obtain C-H and C-C bond dissociation energies. The proposed model has been validated against ignition delay time data, speciation data from a jet-stirred reactor, and laminar flame velocity measurements. Overall, the model shows good agreement with the experiments and permits a detailed discussion of the differences between alcohols and alkanes. © 2012 American Chemical Society.

  8. Detailed kinetic modeling study of n-pentanol oxidation

    KAUST Repository

    Heufer, Karl Alexander

    2012-10-18

    To help overcome the world\\'s dependence upon fossil fuels, suitable biofuels are promising alternatives that can be used in the transportation sector. Recent research on internal combustion engines shows that short alcoholic fuels (e.g., ethanol or n-butanol) have reduced pollutant emissions and increased knock resistance compared to fossil fuels. Although higher molecular weight alcohols (e.g., n-pentanol and n-hexanol) exhibit higher reactivity that lowers their knock resistance, they are suitable for diesel engines or advanced engine concepts, such as homogeneous charge compression ignition (HCCI), where higher reactivity at lower temperatures is necessary for engine operation. The present study presents a detailed kinetic model for n-pentanol based on modeling rules previously presented for n-butanol. This approach was initially validated using quantum chemistry calculations to verify the most stable n-pentanol conformation and to obtain C-H and C-C bond dissociation energies. The proposed model has been validated against ignition delay time data, speciation data from a jet-stirred reactor, and laminar flame velocity measurements. Overall, the model shows good agreement with the experiments and permits a detailed discussion of the differences between alcohols and alkanes. © 2012 American Chemical Society.

  9. Using MultiMedia Content to Present Business Ethics: An Empirical Study

    Science.gov (United States)

    Stanwick, Peter A.

    2010-01-01

    The purpose of this study is to empirically examine whether presenting a multimedia case study enhances the learning experience of students in an undergraduate management class. A questionnaire was administered before and after the presentation of the case study and the results showed that the multimedia case did indeed enhance the learning…

  10. Tidal eddies in a semi-enclosed basin: A model study

    Digital Repository Service at National Institute of Oceanography (India)

    Vethamony, P.; Reddy, G.S.; Babu, M.T.; Desa, E.; Sudheesh, K.

    A modeling study has been carried out to support a Marine Management Plan for the Gulf of Kachchh, India and here the hydrodynamic part of the programme is described. The hydrodynamic model accurately predicts the tides and tidal currents present...

  11. Space engineering modeling and optimization with case studies

    CERN Document Server

    Pintér, János

    2016-01-01

    This book presents a selection of advanced case studies that cover a substantial range of issues and real-world challenges and applications in space engineering. Vital mathematical modeling, optimization methodologies and numerical solution aspects of each application case study are presented in detail, with discussions of a range of advanced model development and solution techniques and tools. Space engineering challenges are discussed in the following contexts: •Advanced Space Vehicle Design •Computation of Optimal Low Thrust Transfers •Indirect Optimization of Spacecraft Trajectories •Resource-Constrained Scheduling, •Packing Problems in Space •Design of Complex Interplanetary Trajectories •Satellite Constellation Image Acquisition •Re-entry Test Vehicle Configuration Selection •Collision Risk Assessment on Perturbed Orbits •Optimal Robust Design of Hybrid Rocket Engines •Nonlinear Regression Analysis in Space Engineering< •Regression-Based Sensitivity Analysis and Robust Design ...

  12. Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS) Users' Workshop Presentations

    Science.gov (United States)

    Litt, Jonathan S. (Compiler)

    2018-01-01

    NASA Glenn Research Center hosted a Users' Workshop on the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS) on August 21, 2017. The objective of this workshop was to update the user community on the latest features of T-MATS, and to provide a forum to present work performed using T-MATS. Presentations highlighted creative applications and the development of new features and libraries, and emphasized the flexibility and simulation power of T-MATS.

  13. Modeling the present and future impact of aviation on climate: an AOGCM approach with online coupled chemistry

    Directory of Open Access Journals (Sweden)

    P. Huszar

    2013-10-01

    Full Text Available Our work is among the first that use an atmosphere-ocean general circulation model (AOGCM with online chemistry to evaluate the impact of future aviation emissions on temperature. Other particularities of our study include non-scaling to the aviation emissions, and the analysis of models' transient response using ensemble simulations. The model we use is the Météo-France CNRM-CM5.1 earth system model extended with the REPROBUS chemistry scheme. The time horizon of our interest is 1940–2100, assuming the A1B SRES scenario. We investigate the present and future impact of aviation emissions of CO2, NOx and H2O on climate, taking into account changes in greenhouse gases, contrails and contrail-induced cirrus (CIC. As in many transport-related impact studies, we distinguish between the climate impacts of CO2 emissions and those of non-CO2 emissions. Aviation-produced aerosol is not considered in the study. Our modeling system simulated a notable sea-ice bias in the Arctic, and therefore results concerning the surface should be viewed with caution. The global averaged near-surface CO2 impact reaches around 0.1 K by the end of the 21st century, while the non-CO2 impact reaches 0.2 K in the second half of the century. The NOx emissions impact is almost negligible in our simulations, as our aviation-induced ozone production is small. As a consequence, the non-CO2 signal is very similar to the CIC signal. The seasonal analysis shows that the strongest warming due to aviation is modeled for the late summer and early autumn. In the stratosphere, a significant cooling is attributed to aviation CO2 emissions (−0.25 K by 2100. A −0.3 K temperature decrease is modeled when considering all the aviation emissions, but no significant signal appears from the CIC or NOx forcings in the stratosphere.

  14. Neural processes underlying the"same"-"different" judgment of two simultaneously presented objects--an EEG study.

    Directory of Open Access Journals (Sweden)

    Ruiling Zhang

    Full Text Available The present study investigated the neural processes underlying "same" and -"different" judgments for two simultaneously presented objects, that varied on one or both, of two dimensions: color and shape. Participants judged whether or not the two objects were "same" or "different" on either the color dimension (color task or the shape dimension (shape task. The unattended irrelevant dimension of the objects was either congruent (same-same; different-different or incongruent (same-different. ERP data showed a main effect of color congruency in the time window 190-260 ms post-stimulus presentation and a main effect of shape congruency in the time window 220-280 ms post-stimulus presentation in both color and shape tasks. The interaction between color and shape congruency in the ERP data occurred in a later time window than the two main effects, indicating that mismatches in task-relevant and task-irrelevant dimensions were processed automatically and independently before a response was selected. The fact that the interference of the task-irrelevant dimension occurred after mismatch detection, supports a confluence model of processing.

  15. Present studies on the radiosterilized drugs

    International Nuclear Information System (INIS)

    Marciniec, B.; Dettlaff, K.

    2007-01-01

    Lecture presents present status of radiosterilization of drugs and medical materials as compared to other sterilization methods. Literature review is shown on degradation of different kinds of drugs sterilized upon action of the sterilising doses of radiation

  16. Western Wind and Solar Integration Study: Phase 2 (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Lew, D.; Brinkman, G.; Ibanez, E.; Lefton, S.; Kumar, N.; Venkataraman, S.; Jordan, G.

    2013-09-01

    This presentation summarizes the scope and results of the Western Wind and Solar Integration Study Phase 2, which examined operational impacts of high penetrations of variable renewable generation in the West.

  17. Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study.

    Science.gov (United States)

    MacLennan, Calman A; Msefula, Chisomo L; Gondwe, Esther N; Gilchrist, James J; Pensulo, Paul; Mandala, Wilson L; Mwimaniwa, Grace; Banda, Meraby; Kenny, Julia; Wilson, Lorna K; Phiri, Amos; MacLennan, Jenny M; Molyneux, Elizabeth M; Molyneux, Malcolm E; Graham, Stephen M

    2017-12-01

    Nontyphoidal Salmonellae commonly cause invasive disease in African children that is often fatal. The clinical diagnosis of these infections is hampered by the absence of a clear clinical syndrome. Drug resistance means that empirical antibiotic therapy is often ineffective and currently no vaccine is available. The study objective was to identify risk factors for mortality among children presenting to hospital with invasive Salmonella disease in Africa. We conducted a prospective study enrolling consecutive children with microbiologically-confirmed invasive Salmonella disease admitted to Queen Elizabeth Central Hospital, Blantyre, in 2006. Data on clinical presentation, co-morbidities and outcome were used to identify children at risk of inpatient mortality through logistic-regression modeling. Over one calendar year, 263 consecutive children presented with invasive Salmonella disease. Median age was 16 months (range 0-15 years) and 52/256 children (20%; 95%CI 15-25%) died. Nontyphoidal serovars caused 248/263 (94%) of cases. 211/259 (81%) of isolates were multi-drug resistant. 251/263 children presented with bacteremia, 6 with meningitis and 6 with both. Respiratory symptoms were present in 184/240 (77%; 95%CI 71-82%), 123/240 (51%; 95%CI 45-58%) had gastrointestinal symptoms and 101/240 (42%; 95%CI 36-49%) had an overlapping clinical syndrome. Presentation at Salmonella disease in Malawi is characterized by high mortality and prevalence of multi-drug resistant isolates, along with non-specific presentation. Young infants, children with dyspnea and HIV-infected children bear a disproportionate burden of the Salmonella-associated mortality in Malawi. Strategies to improve prevention, diagnosis and management of invasive Salmonella disease should be targeted at these children.

  18. Geometric modelling of channel present in reservoir petroleum using Bezier splines; Modelagem da geometria de paleocanais presentes em reservatorios petroliferos usando splines de Bezier

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Carlos Eduardo S. [Universidade Federal de Campina Grande, PB (Brazil). Programa de Recursos Humanos 25 da ANP]. E-mail: carlos@dme.ufcg.edu.br; Silva, Rosana M. da [Universidade Federal de Campina Grande, PB (Brazil). Dept. de Matematica e Estatistica]. E-mail: rosana@dme.ufcg.edu.br

    2004-07-01

    This work presents an implementation of a synthetic model of a channel found in oil reservoir. The generation these models is one of the steps to the characterization and simulation of the equal probable three-dimensional geological scenery. O implemented model was obtained from fitting techniques of geometric modeling of curves and surfaces to the geological parameters (width, thickness, sinuosity and preferential direction) that defines the form to be modeled. The parameter sinuosity is related with the parameter wave length and the local amplitude of the channel, the parameter preferential direction indicates the way of the flow and the declivity of the channel. The modeling technique used to represent the surface of the channel is the sweeping technique, the consist in effectuate a translation operation from a curve along a guide curve. The guide curve, in our implementation, was generated by the interpolation of points obtained form sampled values or simulated of the parameter sinuosity, using the cubic splines of Bezier technique. A semi-ellipse, determinate by the parameter width and thickness, representing a transversal section of the channel, is the transferred curve through the guide curve, generating the channel surface. (author)

  19. Mathematical modelling a case studies approach

    CERN Document Server

    Illner, Reinhard; McCollum, Samantha; Roode, Thea van

    2004-01-01

    Mathematical modelling is a subject without boundaries. It is the means by which mathematics becomes useful to virtually any subject. Moreover, modelling has been and continues to be a driving force for the development of mathematics itself. This book explains the process of modelling real situations to obtain mathematical problems that can be analyzed, thus solving the original problem. The presentation is in the form of case studies, which are developed much as they would be in true applications. In many cases, an initial model is created, then modified along the way. Some cases are familiar, such as the evaluation of an annuity. Others are unique, such as the fascinating situation in which an engineer, armed only with a slide rule, had 24 hours to compute whether a valve would hold when a temporary rock plug was removed from a water tunnel. Each chapter ends with a set of exercises and some suggestions for class projects. Some projects are extensive, as with the explorations of the predator-prey model; oth...

  20. Ecoclimatic indicators to study crop suitability in present and future climatic conditions

    Science.gov (United States)

    Caubel, Julie; Garcia de Cortazar Atauri, Inaki; Huard, Frédéric; Launay, Marie; Ripoche, Dominique; Gouache, David; Bancal, Marie-Odile; Graux, Anne-Isabelle; De Noblet, Nathalie

    2013-04-01

    Climate change is expected to affect both regional and global food production through changes in overall agroclimatic conditions. It is therefore necessary to develop simple tools of crop suitability diagnosis in a given area so that stakeholders can envisage land use adaptations under climate change conditions. The most common way to investigate potential impacts of climate on the evolution of agrosystems is to make use of an array of agroclimatic indicators, which provide synthetic information derived from climatic variables and calculated within fixed periods (i.e. January first - 31th July). However, the information obtained during these periods does not enable to take account of the plant response to climate. In this work, we present some results of the research program ORACLE (Opportunities and Risks of Agrosystems & forests in response to CLimate, socio-economic and policy changEs in France (and Europe). We proposed a suite of relevant ecoclimatic indicators, based on temperature and rainfall, in order to evaluate crop suitability for both present and new climatic conditions. Ecoclimatic indicators are agroclimatic indicators (e.g., grain heat stress) calculated during specific phenological phases so as to take account of the plant response to climate (e.g., the grain filling period, flowering- harvest). These indicators are linked with the ecophysiological processes they characterize (for e.g., the grain filling). To represent this methodology, we studied the suitability of winter wheat in future climatic conditions through three distinct French sites, Toulouse, Dijon and Versailles. Indicators have been calculated using climatic data from 1950 to 2100 simulated by the global climate model ARPEGE forced by a greenhouse effect corresponding to the SRES A1B scenario. The Quantile-Quantile downscaling method was applied to obtain data for the three locations. Phenological stages (emergence, ear 1 cm, flowering, beginning of grain filling and harvest) have been

  1. Contact tracing of tuberculosis: a systematic review of transmission modelling studies.

    Directory of Open Access Journals (Sweden)

    Matt Begun

    Full Text Available The WHO recommended intervention of Directly Observed Treatment, Short-course (DOTS appears to have been less successful than expected in reducing the burden of TB in some high prevalence settings. One strategy for enhancing DOTS is incorporating active case-finding through screening contacts of TB patients as widely used in low-prevalence settings. Predictive models that incorporate population-level effects on transmission provide one means of predicting impacts of such interventions. We aim to identify all TB transmission modelling studies addressing contact tracing and to describe and critically assess their modelling assumptions, parameter choices and relevance to policy. We searched MEDLINE, SCOPUS, COMPENDEX, Google Scholar and Web of Science databases for relevant English language publications up to February 2012. Of the 1285 studies identified, only 5 studies met our inclusion criteria of models of TB transmission dynamics in human populations designed to incorporate contact tracing as an intervention. Detailed implementation of contact processes was only present in two studies, while only one study presented a model for a high prevalence, developing world setting. Some use of relevant data for parameter estimation was made in each study however validation of the predicted impact of interventions was not attempted in any of the studies. Despite a large body of literature on TB transmission modelling, few published studies incorporate contact tracing. There is considerable scope for future analyses to make better use of data and to apply individual based models to facilitate more realistic patterns of infectious contact. Combined with a focus on high burden settings this would greatly increase the potential for models to inform the use of contract tracing as a TB control policy. Our findings highlight the potential for collaborative work between clinicians, epidemiologists and modellers to gather data required to enhance model development

  2. Contact tracing of tuberculosis: a systematic review of transmission modelling studies.

    Science.gov (United States)

    Begun, Matt; Newall, Anthony T; Marks, Guy B; Wood, James G

    2013-01-01

    The WHO recommended intervention of Directly Observed Treatment, Short-course (DOTS) appears to have been less successful than expected in reducing the burden of TB in some high prevalence settings. One strategy for enhancing DOTS is incorporating active case-finding through screening contacts of TB patients as widely used in low-prevalence settings. Predictive models that incorporate population-level effects on transmission provide one means of predicting impacts of such interventions. We aim to identify all TB transmission modelling studies addressing contact tracing and to describe and critically assess their modelling assumptions, parameter choices and relevance to policy. We searched MEDLINE, SCOPUS, COMPENDEX, Google Scholar and Web of Science databases for relevant English language publications up to February 2012. Of the 1285 studies identified, only 5 studies met our inclusion criteria of models of TB transmission dynamics in human populations designed to incorporate contact tracing as an intervention. Detailed implementation of contact processes was only present in two studies, while only one study presented a model for a high prevalence, developing world setting. Some use of relevant data for parameter estimation was made in each study however validation of the predicted impact of interventions was not attempted in any of the studies. Despite a large body of literature on TB transmission modelling, few published studies incorporate contact tracing. There is considerable scope for future analyses to make better use of data and to apply individual based models to facilitate more realistic patterns of infectious contact. Combined with a focus on high burden settings this would greatly increase the potential for models to inform the use of contract tracing as a TB control policy. Our findings highlight the potential for collaborative work between clinicians, epidemiologists and modellers to gather data required to enhance model development and validation and

  3. Modelling the economic losses of historic and present-day high-impact winter storms in Switzerland

    Science.gov (United States)

    Welker, Christoph; Stucki, Peter; Bresch, David; Dierer, Silke; Martius, Olivia; Brönnimann, Stefan

    2014-05-01

    Severe winter storms such as "Vivian" in February 1990 and "Lothar" in December 1999 are among the most destructive meteorological hazards in Switzerland. Disaster severity resulting from such windstorms is attributable, on the one hand, to hazardous weather conditions such as high wind gust speeds; and on the other hand to socio-economic factors such as population density, distribution of values at risk, and damage susceptibility. For present-day winter storms, the data basis is generally good to describe the meteorological development and wind forces as well as the associated socio-economic impacts. In contrast, the information on historic windstorms is overall sparse and the available historic weather and loss reports mostly do not provide quantitative information. This study illustrates a promising technique to simulate the economic impacts of both historic and present winter storms in Switzerland since end of the 19th century. Our approach makes use of the novel Twentieth Century Reanalysis (20CR) spanning 1871-present. The 2-degree spatial resolution of the global 20CR dataset is relatively coarse. Thus, the complex orography of Switzerland is not realistically represented, which has considerable ramifications for the representation of wind systems that are strongly influenced by the local orography, such as Föhn winds. Therefore, a dynamical downscaling of the 20CR to 3 km resolution using the Weather Research and Forecasting (WRF) model was performed, for in total 40 high-impact winter storms in Switzerland since 1871. Based on the downscaled wind gust speeds and the climada loss model, the estimated economic losses were calculated at municipality level for current economic and social conditions. With this approach, we find an answer to the question what would be the economic losses of e.g. a hazardous Föhn storm - which occurred in northern Switzerland in February 1925 - today, i.e. under current socio-economic conditions. Encouragingly, the pattern of

  4. Parametric study for horizontal steam generator modelling

    Energy Technology Data Exchange (ETDEWEB)

    Ovtcharova, I. [Energoproekt, Sofia (Bulgaria)

    1995-12-31

    In the presentation some of the calculated results of horizontal steam generator PGV - 440 modelling with RELAP5/Mod3 are described. Two nodalization schemes have been used with different components in the steam dome. A study of parameters variation on the steam generator work and calculated results is made in cases with separator and branch.

  5. Parametric study for horizontal steam generator modelling

    Energy Technology Data Exchange (ETDEWEB)

    Ovtcharova, I [Energoproekt, Sofia (Bulgaria)

    1996-12-31

    In the presentation some of the calculated results of horizontal steam generator PGV - 440 modelling with RELAP5/Mod3 are described. Two nodalization schemes have been used with different components in the steam dome. A study of parameters variation on the steam generator work and calculated results is made in cases with separator and branch.

  6. Emotional noun processing: an ERP study with rapid serial visual presentation.

    Science.gov (United States)

    Yi, Shengnan; He, Weiqi; Zhan, Lei; Qi, Zhengyang; Zhu, Chuanlin; Luo, Wenbo; Li, Hong

    2015-01-01

    Reading is an important part of our daily life, and rapid responses to emotional words have received a great deal of research interest. Our study employed rapid serial visual presentation to detect the time course of emotional noun processing using event-related potentials. We performed a dual-task experiment, where subjects were required to judge whether a given number was odd or even, and the category into which each emotional noun fit. In terms of P1, we found that there was no negativity bias for emotional nouns. However, emotional nouns elicited larger amplitudes in the N170 component in the left hemisphere than did neutral nouns. This finding indicated that in later processing stages, emotional words can be discriminated from neutral words. Furthermore, positive, negative, and neutral words were different from each other in the late positive complex, indicating that in the third stage, even different emotions can be discerned. Thus, our results indicate that in a three-stage model the latter two stages are more stable and universal.

  7. Emotional noun processing: an ERP study with rapid serial visual presentation.

    Directory of Open Access Journals (Sweden)

    Shengnan Yi

    Full Text Available Reading is an important part of our daily life, and rapid responses to emotional words have received a great deal of research interest. Our study employed rapid serial visual presentation to detect the time course of emotional noun processing using event-related potentials. We performed a dual-task experiment, where subjects were required to judge whether a given number was odd or even, and the category into which each emotional noun fit. In terms of P1, we found that there was no negativity bias for emotional nouns. However, emotional nouns elicited larger amplitudes in the N170 component in the left hemisphere than did neutral nouns. This finding indicated that in later processing stages, emotional words can be discriminated from neutral words. Furthermore, positive, negative, and neutral words were different from each other in the late positive complex, indicating that in the third stage, even different emotions can be discerned. Thus, our results indicate that in a three-stage model the latter two stages are more stable and universal.

  8. Geographical Information System Model for Potential Mines Data Management Presentation in Kabupaten Gorontalo

    Science.gov (United States)

    Roviana, D.; Tajuddin, A.; Edi, S.

    2017-03-01

    Mining potential in Indonesian is very abundant, ranging from Sabang to Marauke. Kabupaten Gorontalo is one of many places in Indonesia that have different types of minerals and natural resources that can be found in every district. The abundant of mining potential must be balanced with good management and ease of getting information by investors. The current issue is, (1) ways of presenting data/information about potential mines area is still manually (the maps that already capture from satellite image, then printed and attached to information board in the office) it caused the difficulties of getting information; (2) the high cost of maps printing; (3) the difficulties of regency leader (bupati) to obtain information for strategic decision making about mining potential. The goal of this research is to build a model of Geographical Information System that could provide data management of potential mines, so that the investors could easily get information according to their needs. To achieve that goal Research and Development method is used. The result of this research, is a model of Geographical Information System that implemented in an application to presenting data management of mines.

  9. Information Presentation

    Science.gov (United States)

    Holden, K.L.; Boyer, J.L.; Sandor, A.; Thompson, S.G.; McCann, R.S.; Begault, D.R.; Adelstein, B.D.; Beutter, B.R.; Stone, L.S.

    2009-01-01

    The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers at Johnson Space Center and Ames Research Center.

  10. Three-Dimensional Model Test Study of Xbloc Armoured Breakwaters at Punta Catalina, Dominican Republic

    DEFF Research Database (Denmark)

    Røge, Mads Sønderstrup; Andersen, Thomas Lykke

    The present report presents results from a three-dimensional model test study carried out at Aalborg University in the period June 2015 – August 2015. The objectives of the model tests were to study the stability of the Xbloc armoured breakwaters at Punta Catalina under short-crested wave attack...

  11. Two-Dimensional Model Test Study of New Western Breakwater Proposal for Port of Hanstholm

    DEFF Research Database (Denmark)

    Eldrup, Mads Røge; Andersen, Thomas Lykke

    The present report presents results from a two-dimensional model test study carried out at Aalborg University in December 2016 with the proposed trunk section for the new western breakwater in Port of Hanstholm. The objectives of the model tests were to study the stability of the armour layer, toe...... erosion, overtopping and transmission. The scale used for the model tests was 1:61.5. Unless otherwise specified all values given in this report are prototype values converted from the model to prototype according to the Froude model law....

  12. Modelling and propagation of uncertainties in the German Risk Study

    International Nuclear Information System (INIS)

    Hofer, E.; Krzykacz, B.

    1982-01-01

    Risk assessments are generally subject to uncertainty considerations. This is because of the various estimates that are involved. The paper points out those estimates in the so-called phase A of the German Risk Study, for which uncertainties were quantified. It explains the probabilistic models applied in the assessment to their impact on the findings of the study. Finally the resulting subjective confidence intervals of the study results are presented and their sensitivity to these probabilistic models is investigated

  13. Quantitative modelling and analysis of a Chinese smart grid: a stochastic model checking case study

    DEFF Research Database (Denmark)

    Yuksel, Ender; Nielson, Hanne Riis; Nielson, Flemming

    2014-01-01

    Cyber-physical systems integrate information and communication technology with the physical elements of a system, mainly for monitoring and controlling purposes. The conversion of traditional power grid into a smart grid, a fundamental example of a cyber-physical system, raises a number of issues...... that require novel methods and applications. One of the important issues in this context is the verification of certain quantitative properties of the system. In this paper, we consider a specific Chinese smart grid implementation as a case study and address the verification problem for performance and energy...... consumption.We employ stochastic model checking approach and present our modelling and analysis study using PRISM model checker....

  14. Spacelab experiment computer study. Volume 1: Executive summary (presentation)

    Science.gov (United States)

    Lewis, J. L.; Hodges, B. C.; Christy, J. O.

    1976-01-01

    A quantitative cost for various Spacelab flight hardware configurations is provided along with varied software development options. A cost analysis of Spacelab computer hardware and software is presented. The cost study is discussed based on utilization of a central experiment computer with optional auxillary equipment. Groundrules and assumptions used in deriving the costing methods for all options in the Spacelab experiment study are presented. The groundrules and assumptions, are analysed and the options along with their cost considerations, are discussed. It is concluded that Spacelab program cost for software development and maintenance is independent of experimental hardware and software options, that distributed standard computer concept simplifies software integration without a significant increase in cost, and that decisions on flight computer hardware configurations should not be made until payload selection for a given mission and a detailed analysis of the mission requirements are completed.

  15. Two-Dimensional Model Test Study of New Western Breakwater Proposal for Port of Hanstholm

    OpenAIRE

    Eldrup, Mads Røge; Andersen, Thomas Lykke

    2016-01-01

    The present report presents results from a two-dimensional model test study carried out at Aalborg University in December 2016 with the proposed trunk section for the new western breakwater in Port of Hanstholm. The objectives of the model tests were to study the stability of the armour layer, toe erosion, overtopping and transmission. The scale used for the model tests was 1:61.5. Unless otherwise specified all values given in this report are prototype values converted from the model to prot...

  16. A study on the modeling techniques using LS-INGRID

    Energy Technology Data Exchange (ETDEWEB)

    Ku, J. H.; Park, S. W

    2001-03-01

    For the development of radioactive material transport packages, the verification of structural safety of a package against the free drop impact accident should be carried out. The use of LS-DYNA, which is specially developed code for impact analysis, is essential for impact analysis of the package. LS-INGRID is a pre-processor for LS-DYNA with considerable capability to deal with complex geometries and allows for parametric modeling. LS-INGRID is most effective in combination with LS-DYNA code. Although the usage of LS-INGRID seems very difficult relative to many commercial mesh generators, the productivity of users performing parametric modeling tasks with LS-INGRID can be much higher in some cases. Therefore, LS-INGRID has to be used with LS-DYNA. This report presents basic explanations for the structure and commands, basic modelling examples and advanced modelling of LS-INGRID to use it for the impact analysis of various packages. The new users can build the complex model easily, through a study for the basic examples presented in this report from the modelling to the loading and constraint conditions.

  17. A Dynamic Wind Generation Model for Power Systems Studies

    OpenAIRE

    Estanqueiro, Ana

    2007-01-01

    In this paper, a wind park dynamic model is presented together with a base methodology for its application to power system studies. This detailed wind generation model addresses the wind turbine components and phenomena more relevant to characterize the power quality of a grid connected wind park, as well as the wind park response to the grid fast perturbations, e.g., low voltage ride through fault. The developed model was applied to the operating conditions of the selected sets of wind turbi...

  18. Presentation Technique

    International Nuclear Information System (INIS)

    Froejmark, M.

    1992-10-01

    The report presents a wide, easily understandable description of presentation technique and man-machine communication. General fundamentals for the man-machine interface are illustrated, and the factors that affect the interface are described. A model is presented for describing the operators work situation, based on three different levels in the operators behaviour. The operator reacts routinely in the face of simple, known problems, and reacts in accordance with predetermined plans in the face of more complex, recognizable problems. Deep fundamental knowledge is necessary for truly complex questions. Today's technical status and future development have been studied. In the future, the operator interface will be based on standard software. Functions such as zooming, integration of video pictures, and sound reproduction will become common. Video walls may be expected to come into use in situations in which several persons simultaneously need access to the same information. A summary of the fundamental rules for the design of good picture ergonomics and design requirements for control rooms are included in the report. In conclusion, the report describes a presentation technique within the Distribution Automation and Demand Side Management area and analyses the know-how requirements within Vattenfall. If different systems are integrated, such as geographical information systems and operation monitoring systems, strict demands are made on the expertise of the users for achieving a user-friendly technique which is matched to the needs of the human being. (3 figs.)

  19. The Relationship between Spiritual Health and other Dimensions of Health: Presentation of a Model

    Directory of Open Access Journals (Sweden)

    Akram Heidari

    2016-06-01

    Full Text Available Attitudes to humankind will have different effects on health service delivery. Health might used to be intended to provide physical health in the past; today, however, many researchers and clinicians consider the concept health to be beyond physical health. In support of this claim, it is enough to indicate that the bio-psycho-social model has for years been held by scientific communities to be a fully admitted model. However, the missing ring in this model, as suggested by many, is the spiritual health. In recent years, the relationship between spirituality and clinical interventions with a comprehensive focus on health has been under increasing scrutiny. Although different models have been presented for investigation of the relationship between spiritual health and other dimensions, the fundamental challenge in this regard is the actual place of spiritual health compared with other dimensions. In this article, attempts are made to address the position and weight of spiritual health from the Islam’s point of view.

  20. Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs.

    Science.gov (United States)

    Löscher, Wolfgang

    2017-07-01

    The identification of potential therapeutic agents for the treatment of epilepsy requires the use of seizure models. Except for some early treatments, including bromides and phenobarbital, the antiseizure activity of all clinically used drugs was, for the most part, defined by acute seizure models in rodents using the maximal electroshock and subcutaneous pentylenetetrazole seizure tests and the electrically kindled rat. Unfortunately, the clinical evidence to date would suggest that none of these models, albeit useful, are likely to identify those therapeutics that will effectively manage patients with drug resistant seizures. Over the last 30 years, a number of animal models have been developed that display varying degrees of pharmacoresistance, such as the phenytoin- or lamotrigine-resistant kindled rat, the 6-Hz mouse model of partial seizures, the intrahippocampal kainate model in mice, or rats in which spontaneous recurrent seizures develops after inducing status epilepticus by chemical or electrical stimulation. As such, these models can be used to study mechanisms of drug resistance and may provide a unique opportunity for identifying a truly novel antiseizure drug (ASD), but thus far clinical evidence for this hope is lacking. Although animal models of drug resistant seizures are now included in ASD discovery approaches such as the ETSP (epilepsy therapy screening program), it is important to note that no single model has been validated for use to identify potential compounds for as yet drug resistant seizures, but rather a battery of such models should be employed, thus enhancing the sensitivity to discover novel, highly effective ASDs. The present review describes the previous and current approaches used in the search for new ASDs and offers some insight into future directions incorporating new and emerging animal models of therapy resistance.

  1. Proposing a Model to present Factors which Affect e-SCM Risk and their Impacts on Organizational Performance

    Directory of Open Access Journals (Sweden)

    ali rajabzadeh ghatari

    2010-03-01

    Full Text Available Companies strive to improve market share, grow corporate profit, and gain strategic advantage. In order to achieve these goals, supply chain competency must be placed at the heart of a company’s business model. Using e-Commerce and information and communication technologies (ICT in today’s changing demands of business has made organizations more responsive and flexible. E-Commerce and Internet have changed the nature of supply chains and re-defined how customers obtain wisdom of products, services, selection, purchasing and using them. Advent of ICT and new business environment has caused emerge of electronic supply chains. This research has proposed a model for presenting factors which affect electronic supply chain’s risk; besides the influence of the risk on financial and non-financial organization’s performance indicators. Studying the influence of the risk on organization’s performance is conducted in a sample of electronic and telecommunication companies. In order to measure these relationships, using correlation and structural equation modeling (SEM techniques proposed that electronic supply chain risk identification and management have significant impact on organization’s performance improvement.

  2. Study of microorganisms present in deep geologic formations

    International Nuclear Information System (INIS)

    Camus, H.; Lion, R.; Bianchi, A.; Garcin, J.

    1987-01-01

    This work has been executed in the scope of the studies on high activity radioactive wastes storage in deep geological environments. The authors make reference to an as complete as possible literature on the existence of microorganisms in those environments or under similar conditions. Then they describe the equipment and methods they have implemented to perform their study of the populations present in three deep-reaching drill-holes in Auriat (France), Mol (Belgique) and Troon (Great Britain). The results of the study exhibit the presence of a certain biological activity, well adapted to that particular life environment. Strains appear to be very varied from the taxonomic point of view and seemingly show an important potential of mineral alteration when provided with an adequate source of energy. Complementary studies, using advanced techniques such as those employed during the work forming the basis of this paper, seem necessary for a more accurate evaluation of long-term risks of perturbation of a deep storage site [fr

  3. A RETROSPECTIVE STUDY ON CLINICAL PRESENTATION OF STEROID SENSITIVE NEPHROTIC SYNDROME

    Directory of Open Access Journals (Sweden)

    Sosamma M. M

    2016-09-01

    Full Text Available BACKGROUND Nephrotic syndrome is a disease affecting the renal system. Most paediatricians will invariably encounter children with nephrotic syndrome in their clinic. The disease is characterised by the presence of oedema, persistent heavy proteinuria, hypoproteinaemia and hypercholesterolaemia. The disease is influenced by factors like age, geography, race and also has certain genetic influence related to HLA (DR7, B12, B8. In children, minimal change nephrotic syndrome is the most common variant of primary nephrotic syndrome. It accounts to more than eighty per cent of the cases seen children under seven years whereas it has a chance of fifty per cent in the age group of seven to sixteen years. Males are affected two times higher compared to females. The parents usually bring the child to the hospital with signs of oedema. Usually, the child recovers with treatment, but in some cases, there can be relapse. MATERIALS AND METHODS  The study was conducted in the Department of Paediatrics, Travancore Medical College, Kollam.  The study was done from January 2015 to January 2016.  Sixty cases were identified and were chosen for the study. INCLUSION CRITERIA 1. Steroid sensitive cases of nephrotic syndrome. 2. Age less than twelve years. 3. Admitted cases. EXCLUSION CRITERIA 1. Steroid-resistant and steroid-dependent cases. 2. Age more than twelve years. 3. Outpatient cases. RESULTS Out of the sixty cases studied, forty one cases belonged to male sex and nineteen cases belonged to female sex. Based on the age group, maximum number of cases belonged to age group four to eight years, which amounted to thirty four cases followed by age group eight to twelve years, which amounted to eighteen cases. Age group zero to four years had the least number of cases, which amounted to eight in number. Based on clinical signs and symptoms, fifty five cases presented with oedema either periorbital, scrotal or pedal oedema. Ten cases presented with fever

  4. Introducing WISDEM:An Integrated System Modeling for Wind Turbines and Plant (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Dykes, K.; Graf, P.; Scott, G.; Ning, A.; King, R.; Guo, Y.; Parsons, T.; Damiani, R.; Felker, F.; Veers, P.

    2015-01-01

    The National Wind Technology Center wind energy systems engineering initiative has developed an analysis platform to leverage its research capabilities toward integrating wind energy engineering and cost models across wind plants. This Wind-Plant Integrated System Design & Engineering Model (WISDEM) platform captures the important interactions between various subsystems to achieve a better National Wind Technology Center wind energy systems engineering initiative has developed an analysis platform to leverage its research capabilities toward integrating wind energy engineering and cost models across wind plants. This Wind-Plant Integrated System Design & Engineering Model (WISDEM) platform captures the important interactions between various subsystems to achieve a better understanding of how to improve system-level performance and achieve system-level cost reductions. This work illustrates a few case studies with WISDEM that focus on the design and analysis of wind turbines and plants at different system levels.

  5. MODELING SIMULATION AND PERFORMANCE STUDY OF GRIDCONNECTED PHOTOVOLTAIC ENERGY SYSTEM

    OpenAIRE

    Nagendra K; Karthik J; Keerthi Rao C; Kumar Raja Pemmadi

    2017-01-01

    This paper presents Modeling Simulation of grid connected Photovoltaic Energy System and performance study using MATLAB/Simulink. The Photovoltaic energy system is considered in three main parts PV Model, Power conditioning System and Grid interface. The Photovoltaic Model is inter-connected with grid through full scale power electronic devices. The simulation is conducted on the PV energy system at normal temperature and at constant load by using MATLAB.

  6. Contribution to the study of conformal theories and integrable models

    International Nuclear Information System (INIS)

    Sochen, N.

    1992-05-01

    The purpose of this thesis is the 2-D physics study. The main tool is the conformal field theory with Kac-Moody and W algebra. This theory describes the 2-D models that have translation, rotation and dilatation symmetries, at their critical point. The expanded conformal theories describe models that have a larger symmetry than conformal symmetry. After a review of conformal theory methods, the author effects a detailed study of singular vector form in sl(2) affine algebra. With this important form, correlation functions can be calculated. The classical W algebra is studied and the relations between classical W algebra and quantum W algebra are specified. Bosonization method is presented and sl(2)/sl(2) topological model, studied. Partition function bosonization of different models is described. A program of rational theory classification is described linking rational conformal theories and spin integrable models, and interesting relations between Boltzmann weights of different models have been found. With these relations, the integrability of models by a direct calculation of their Boltzmann weights is proved

  7. Crystal study and econometric model

    Science.gov (United States)

    1975-01-01

    An econometric model was developed that can be used to predict demand and supply figures for crystals over a time horizon roughly concurrent with that of NASA's Space Shuttle Program - that is, 1975 through 1990. The model includes an equation to predict the impact on investment in the crystal-growing industry. Actually, two models are presented. The first is a theoretical model which follows rather strictly the standard theoretical economic concepts involved in supply and demand analysis, and a modified version of the model was developed which, though not quite as theoretically sound, was testable utilizing existing data sources.

  8. ICRF edge modeling studies

    Energy Technology Data Exchange (ETDEWEB)

    Lehrman, I.S. (Grumman Corp. Research Center, Princeton, NJ (USA)); Colestock, P.L. (Princeton Univ., NJ (USA). Plasma Physics Lab.)

    1990-04-01

    Theoretical models have been developed, and are currently being refined, to explain the edge plasma-antenna interaction that occurs during ICRF heating. The periodic structure of a Faraday shielded antenna is found to result in strong ponderomotive force in the vicinity of the antenna. A fluid model, which incorporates the ponderomotive force, shows an increase in transport to the Faraday shield. A kinetic model shows that the strong antenna near fields act to increase the energy of deuterons which strike the shield, thereby increasing the sputtering of shield material. Estimates of edge impurity harmonic heating show no significant heating for either in or out-of-phase antenna operation. Additionally, a particle model for electrons near the shield shows that heating results from the parallel electric field associated with the fast wave. A quasilinear model for edge electron heating is presented and compared to the particle calculations. The models' predictions are shown to be consistent with measurements of enhanced transport. (orig.).

  9. A multiple-compartment model for biokinetics studies in plants

    International Nuclear Information System (INIS)

    Garcia, Fermin; Pietrobron, Flavio; Fonseca, Agnes M.F.; Mol, Anderson W.; Rodriguez, Oscar; Guzman, Fernando

    2001-01-01

    In the present work is used the system of linear equations based in the general Assimakopoulos's GMCM model , for the development of a new method that will determine the flow's parameters and transfer coefficients in plants. The need of mathematical models to quantify the penetration of a trace substance in animals and plants, has often been stressed in the literature. Usually, in radiological environment studies, it is used the mean value of contaminant concentrations on whole or edible part plant body, without taking in account vegetable physiology regularities. In this work concepts and mathematical formulation of a Vegetable Multi-compartment Model (VMCM), taking into account the plant's physiology regularities is presented. The model based in general ideas of the GMCM , and statistical Square Minimum Method STATFLUX is proposed to use in inverse sense: the experimental time dependence of concentration in each compartment, should be input, and the parameters should be determined from this data in a statistical approach. The case of Uranium metabolism is discussed. (author)

  10. Presentation of Austrians recommended dispersion model for tunnel portals

    Energy Technology Data Exchange (ETDEWEB)

    Oettl, D.; Sturm, P.; Almbauer, R. [Inst. for Internal Combustion Engines and Thermodynamics, Graz Univ. of Technology (Austria)

    2004-07-01

    Street tunnels in cities are often suggested as solution to avoid daily congestions but also to prevent residential areas from high noise and air pollution emissions. In case of longitudinal ventilated tunnels high pollution levels may occur in the vicinity of the portals. The dispersion of pollutants from tunnel portals is considered to differ significantly from those of other sources, such as line or point sources. To the best of the authors knowledge, there exist currently two distinct dispersion models, which are especially designed to treat dispersion from tunnel portals. Okamoto et al proposed a diagnostic wind field model, where the dispersion is modelled using a Taylor-Galerkin-Forester filter method. Oettl et al. developed a Lagrangian-type model (GRAL TM 3.5=Graz Lagrangian model Tunnel Module version 3.5), which is briefly described in the next section. (orig.)

  11. A study of critical two-phase flow models

    International Nuclear Information System (INIS)

    Siikonen, T.

    1982-01-01

    The existing computer codes use different boundary conditions in the calculation of critical two-phase flow. In the present study these boundary conditions are compared. It is shown that the boundary condition should be determined from the hydraulic model used in the computer code. The use of a correlation, which is not based on the hydraulic model used, leads often to bad results. Usually a good agreement with data is obtained in the calculation as far as the critical mass flux is concerned, but the agreement is not so good in the pressure profiles. The reason is suggested to be mainly in inadequate modeling of non-equilibrium effects. (orig.)

  12. A modeling and control framework for operating large-scale electric power systems under present and newly evolving competitive industry structures

    Directory of Open Access Journals (Sweden)

    Marija D. Ilić

    1995-01-01

    Full Text Available This paper introduces a systematic, structure-based modeling framework for analysis and control of electric power systems for processes evolving over the mid-term and long-term time horizons. Much simpler models than the detailed dynamics specifically for control design at different hierarchical levels are obtained by applying both temporal and spatial separation. These simple models, or the aggregate models, represent the net effect of interactions among interconnected regions on specific hierarchical levels. They are exact, since no assumptions on weak interconnections among the subsystems are made. Moreover they are easily understood in terms of power flows among the regions. The approach is essential for improving present performance of the system. It is also potentially useful in a competitive utility environment in which it is critical to study the interplay between technical and economic processes.

  13. Multi-nutrient, multi-group model of present and future oceanic phytoplankton communities

    Directory of Open Access Journals (Sweden)

    E. Litchman

    2006-01-01

    Full Text Available Phytoplankton community composition profoundly affects patterns of nutrient cycling and the dynamics of marine food webs; therefore predicting present and future phytoplankton community structure is crucial to understand how ocean ecosystems respond to physical forcing and nutrient limitations. We develop a mechanistic model of phytoplankton communities that includes multiple taxonomic groups (diatoms, coccolithophores and prasinophytes, nutrients (nitrate, ammonium, phosphate, silicate and iron, light, and a generalist zooplankton grazer. Each taxonomic group was parameterized based on an extensive literature survey. We test the model at two contrasting sites in the modern ocean, the North Atlantic (North Atlantic Bloom Experiment, NABE and subarctic North Pacific (ocean station Papa, OSP. The model successfully predicts general patterns of community composition and succession at both sites: In the North Atlantic, the model predicts a spring diatom bloom, followed by coccolithophore and prasinophyte blooms later in the season. In the North Pacific, the model reproduces the low chlorophyll community dominated by prasinophytes and coccolithophores, with low total biomass variability and high nutrient concentrations throughout the year. Sensitivity analysis revealed that the identity of the most sensitive parameters and the range of acceptable parameters differed between the two sites. We then use the model to predict community reorganization under different global change scenarios: a later onset and extended duration of stratification, with shallower mixed layer depths due to increased greenhouse gas concentrations; increase in deep water nitrogen; decrease in deep water phosphorus and increase or decrease in iron concentration. To estimate uncertainty in our predictions, we used a Monte Carlo sampling of the parameter space where future scenarios were run using parameter combinations that produced acceptable modern day outcomes and the

  14. Hera presentation generator (Poster)

    NARCIS (Netherlands)

    Frasincar, F.; Houben, G.J.P.M.; Barna, P.; Ellis, A.; Hagino, T.

    2005-01-01

    Semantic Web Information Systems (SWIS) are Web Information Systems that use Semantic Web technologies. Hera is a model-driven design methodology for SWIS. In Hera, models are represented in RDFS and model instances in RDF. The Hera Presentation Generator (HPG) is an integrated development

  15. The effect of PLS regression in PLS path model estimation when multicollinearity is present

    DEFF Research Database (Denmark)

    Nielsen, Rikke; Kristensen, Kai; Eskildsen, Jacob

    PLS path modelling has previously been found to be robust to multicollinearity both between latent variables and between manifest variables of a common latent variable (see e.g. Cassel et al. (1999), Kristensen, Eskildsen (2005), Westlund et al. (2008)). However, most of the studies investigate...... models with relatively few variables and very simple dependence structures compared to the models that are often estimated in practical settings. A recent study by Nielsen et al. (2009) found that when model structure is more complex, PLS path modelling is not as robust to multicollinearity between...... latent variables as previously assumed. A difference in the standard error of path coefficients of as much as 83% was found between moderate and severe levels of multicollinearity. Large differences were found not only for large path coefficients, but also for small path coefficients and in some cases...

  16. Construction of a biodynamic model for Cry protein production studies.

    Science.gov (United States)

    Navarro-Mtz, Ana Karin; Pérez-Guevara, Fermín

    2014-12-01

    Mathematical models have been used from growth kinetic simulation to gen regulatory networks prediction for B. thuringiensis culture. However, this culture is a time dependent dynamic process where cells physiology suffers several changes depending on the changes in the cell environment. Therefore, through its culture, B. thuringiensis presents three phases related with the predominance of three major metabolic pathways: vegetative growth (Embded-Meyerhof-Parnas pathway), transition (γ-aminobutiric cycle) and sporulation (tricarboxylic acid cycle). There is not available a mathematical model that relates the different stages of cultivation with the metabolic pathway active on each one of them. Therefore, in the present study, and based on published data, a biodynamic model was generated to describe the dynamic of the three different phases based on their major metabolic pathways. The biodynamic model is used to study the interrelation between the different culture phases and their relationship with the Cry protein production. The model consists of three interconnected modules where each module represents one culture phase and its principal metabolic pathway. For model validation four new fermentations were done showing that the model constructed describes reasonably well the dynamic of the three phases. The main results of this model imply that poly-β-hydroxybutyrate is crucial for endospore and Cry protein production. According to the yields of dipicolinic acid and Cry from poly-β-hydroxybutyrate, calculated with the model, the endospore and Cry protein production are not just simultaneous and parallel processes they are also competitive processes.

  17. Thyroid Autoantibodies and the Clinical Presentation of Moyamoya Disease: A Prospective Study.

    Science.gov (United States)

    Lanterna, Luigi A; Galliani, Silvia; Zangari, Rosalia; Conti, Luciano; Brembilla, Carlo; Gritti, Paolo; Colleoni, Maria Luisa; Bernucci, Claudio

    2018-05-01

    Moyamoya is a rare cerebrovascular disease characterized by the progressive occlusion of the intracranial carotid artery. Thyroid autoantibodies have been found to be associated with the disease, but their clinical significance has never been studied. The objective of this study was to investigate the relationship between thyroid autoantibodies and the clinical presentation of moyamoya. This is a prospective study including 37 patients with moyamoya disease (MMD) or unilateral moyamoya (uMM). Thyroid function and thyroid autoantibodies (e.g., antithyroperoxidase and antithyroglobulin) were investigated. We studied the effect of gender, age, type of moyamoya (uMM versus MMD), and thyroid autoantibodies on the clinical presentation, dichotomized into aggressive (hemorrhage, major stroke, or frequent transient ischemic attack [TIA]) and nonaggressive presentation (headache, rare TIAs, and incidental diagnosis) according to the criteria of the Research Committee on Spontaneous Occlusion of the Circle of Willis. Of the 37 patients included in the study, the autoantibodies were elevated in 9 (24.3%). An aggressive presentation occurred in 21 patients (hemorrhage in 11, major stroke in 9, frequent TIAs in 1). The autoantibodies were elevated in 8 of the 21 patients (38.09%) with an aggressive presentation and in 1 of those presenting with minor symptoms (6.2%). The presence of elevated autoantibodies was the only variable associated with an aggressive presentation in the multivariate logistic analysis (P = .048). When the serum concentration of the thyroid autoantibodies is increased, the patients have a higher risk of an aggressive presentation. Our results support the hypothesis that activation of immune-mediated processes affects the moyamoya physiopathology. Copyright © 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  18. Volatile particles formation during PartEmis: a modelling study

    Directory of Open Access Journals (Sweden)

    X. Vancassel

    2004-01-01

    Full Text Available A modelling study of the formation of volatile particles in a combustor exhaust has been carried out in the frame of the PartEmis European project. A kinetic model has been used in order to investigate nucleation efficiency of the H2O-H2SO4 binary mixture in the sampling system. A value for the fraction of the fuel sulphur S(IV converted into S(VI has been indirectly deduced from comparisons between model results and measurements. In the present study, ranges between roughly 2.5% and 6%, depending on the combustor settings and on the value assumed for the parameter describing sulphuric acid wall losses. Soot particles hygroscopicity has also been investigated as their activation is a key parameter for contrail formation. Growth factors of monodisperse particles exposed to high relative humidity (95% have been calculated and compared with experimental results. The modelling study confirms that the growth factor increases as the soot particle size decreases.

  19. Injury Based on Its Study in Experimental Models

    Directory of Open Access Journals (Sweden)

    M. Mendes-Braz

    2012-01-01

    Full Text Available The present review focuses on the numerous experimental models used to study the complexity of hepatic ischemia/reperfusion (I/R injury. Although experimental models of hepatic I/R injury represent a compromise between the clinical reality and experimental simplification, the clinical transfer of experimental results is problematic because of anatomical and physiological differences and the inevitable simplification of experimental work. In this review, the strengths and limitations of the various models of hepatic I/R are discussed. Several strategies to protect the liver from I/R injury have been developed in animal models and, some of these, might find their way into clinical practice. We also attempt to highlight the fact that the mechanisms responsible for hepatic I/R injury depend on the experimental model used, and therefore the therapeutic strategies also differ according to the model used. Thus, the choice of model must therefore be adapted to the clinical question being answered.

  20. DEVELOPING VISUAL PRESENTATION ATTITUDE RUBRIC: VALIDITY AND RELIABILITY STUDY

    OpenAIRE

    ATEŞ, Hatice KADIOĞLU; ADA, Sefer; BAYSAL, Z. Nurdan

    2015-01-01

    Abstract The aim of this study is to develop visual presentation attitude rubric which is valid and reliable for the 4th grade students. 218 students took part in this study from Engin Can Güre which located in Istanbul, Esenler. While preparing this assessment tool with 34 criterias , 6 university lecturers view have been taken who are experts in their field. The answer key sheet has 4 (likert )type options. The rubric has been first tested by Kaiser-Meyer Olkin and Bartletts tests an...

  1. Nonelectrolyte NRTL-NRF model to study thermodynamics of strong and weak electrolyte solutions

    Energy Technology Data Exchange (ETDEWEB)

    Haghtalab, Ali, E-mail: haghtala@modares.ac.i [Department of Chemical Engineering, Tarbiat Modares University, P.O. Box 14115-143, Tehran (Iran, Islamic Republic of); Shojaeian, Abolfazl; Mazloumi, Seyed Hossein [Department of Chemical Engineering, Tarbiat Modares University, P.O. Box 14115-143, Tehran (Iran, Islamic Republic of)

    2011-03-15

    An electrolyte activity coefficient model is proposed by combining non-electrolyte NRTL-NRF local composition model and Pitzer-Debye-Hueckel equation as short-range and long-range contributions, respectively. With two adjustable parameters per each electrolyte, the present model is applied to correlation of the mean activity coefficients of more than 150 strong aqueous electrolyte solutions at 298.15 K. Also the results of the present model are compared with the other local composition models such as electrolyte-NRTL, electrolyte-NRTL-NRF and electrolyte-Wilson-NRF models. Moreover, the present model is used for prediction of the osmotic coefficient of several aqueous binary electrolytes systems at 298.15 K. Also the present activity coefficient model is adopted for representation of nonideality of the acid gases, as weak gas electrolytes, soluble in alkanolamine solutions. The model is applied for calculation of solubility and heat of absorption (enthalpy of solution) of acid gas in the two {l_brace}(H{sub 2}O + MDEA + CO{sub 2}) and (H{sub 2}O + MDEA + H{sub 2}S){r_brace} systems at different conditions. The results demonstrate that the present model can be successfully applied to study thermodynamic properties of both strong and weak electrolyte solutions.

  2. A Study on Uncertainty Quantification of Reflood Model using CIRCE Methodology

    International Nuclear Information System (INIS)

    Jeon, Seongsu; Hong, Soonjoon; Oh, Deogyeon; Bang, Youngseok

    2013-01-01

    The CIRCE method is intended to quantify the uncertainties of the correlations of a code. It may replace the expert judgment generally used. In this study, an uncertainty quantification of reflood model was performed using CIRCE methodology. In this paper, the application process of CIRCE methodology and main results are briefly described. This research is expected to be useful to improve the present audit calculation methodology, KINS-REM. In this study, an uncertainty quantification of reflood model was performed using CIRCE methodology. The application of CIRCE provided the satisfactory results. This research is expected to be useful to improve the present audit calculation methodology, KINS-REM

  3. Spotlight on the presenter : a study into presentations of conference papers with PowerPoint

    NARCIS (Netherlands)

    Hertz, B.

    2015-01-01

    Abstract

    1. Introduction

    PowerPoint is the most widely used presentation software tool. As of 2012, PowerPoint had more than 200 million presenters worldwide. Presenters all over the world use the program. Some use it for university teaching, others

  4. Modelling and experimental studies on a mixed-mode natural convection solar crop-dryer

    Energy Technology Data Exchange (ETDEWEB)

    Forson, F.K. [Department of Mechanical Engineering, Kwame Nkrumah University of Science and Technology, Kumasi (Ghana); Nazha, M.A.A.; Rajakaruna, H. [School of Engineering and Technology, De Montfort University, Queens Building, Leicester LE1 9BH (United Kingdom)

    2007-03-15

    A mathematical model for drying agricultural products in a mixed-mode natural convection solar crop dryer (MNCSCD) using a single-pass double-duct solar air-heater (SPDDSAH) is presented. The model was developed in parallel with experimental work. The model comprises the air-heating process model, the drying model and the technical performance criteria model. The governing equations of the drying air temperature and humidity ratio; the material temperature and its moisture content; and performance criteria indicators are derived. The model requires the solution of a number of interrelated non-linear equations and a set of simultaneous differential equations. Results from experimental studies used for generating the required experimental data for validating the model are presented. Results of simulation runs using the model are presented and compared with the experimental data. It is shown that the model can predict the performance of the MNCSCD fairly accurately and therefore can be used as a design tool for prototype development. (author)

  5. Experimental and modelling studies of infiltration

    International Nuclear Information System (INIS)

    Giudici, M.

    2004-01-01

    This presentation describes a study of infiltration in the unsaturated soil with the objective of estimating the recharge to a phreatic aquifer. The study area is at the border of the city of Milan (Northern Italy), which draws water for both domestic and industrial purposes from ground water resources located beneath the urban area. The rate of water pumping from the aquifer system has been varying during the XX century, depending upon the number of inhabitants and the development of industrial activities. This caused variations with time of the depth of the water table below the ground surface and in turn some emergencies: the two most prominent episodes correspond to the middle '70s, when the water table in the city centre was about 30 m below the undisturbed natural conditions, and to the last decade, when the water table has raised at a rate of approximately 1 m/year and caused infiltrations in deep constructions (garages and building foundations, the underground railways, etc.). We have developed four ground water flow models at different scales, which share some characteristics: they are based on quasi-3D approximation (horizontal flow in the aquifers and vertical flow in the aquitards), conservative finite-differences schemes for regular grid with square cells in the horizontal plane and are implemented with proprietary computer codes. Among the problems that were studied for the development of these models, I recall some numerical problems, related to the behaviour of the phreatic aquifer under conditions of strong exploitation. Model calibration and validation for ModMil has been performed with a two-stage process, i.e., using some of the available data for model calibration and the remaining data for model validation. The application of geophysical exploration techniques, in particular seismic and geo-electrical prospecting, has been very useful to complete the data and information on the hydro-geological structure obtained from stratigraphic logs

  6. Technical data report : marine acoustics modelling study

    Energy Technology Data Exchange (ETDEWEB)

    Chorney, N.; Warner, G.; Austin, M. [Jasco Applied Sciences, Victoria, BC (Canada)

    2010-07-01

    This study was conducted to predict the ensonification produced by vessel traffic transiting to and from the Enbridge Northern Gateway Project's marine terminal located near Kitimat, British Columbia (BC). An underwater acoustic propagation model was used to model frequency bands from 20 Hz to 5 kHz at a standard depth of 20 metres. The model included bathymetric grids of the modelling area; underwater sound speed as a function of depth; and geo-acoustic profiles based on the stratified composition of the seafloor. The obtained 1/3 octave band levels were then used to determine broadband received sound levels for 4 scenarios along various transit routes: the Langara and Triple Island in Dixon Entrance; the Browning Entrance in Hecate Strait, and Cape St. James in the Queen Charlotte Basin. The scenarios consisted of a tanker transiting at 16 knots, and an accompanying tug boat. Underwater sound level maps for each scenario were presented. 14 refs., 5 tabs., 16 figs.

  7. Initial experience with a group presentation of study results to research participants

    Directory of Open Access Journals (Sweden)

    Bent Stephen

    2008-03-01

    Full Text Available Abstract Background Despite ethical imperatives, informing research participants about the results of the studies in which they take part is not often performed. This is due, in part, to the costs and burdens of communicating with each participant after publication of the results. Methods Following the closeout and publication of a randomized clinical trial of saw palmetto for treatment of symptoms of benign prostatic hyperplasia, patients were invited back to the research center to participate in a group presentation of the study results. Results Approximately 10% of participants attended one of two presentation sessions. Reaction to the experience of the group presentation was very positive among the attendees. Conclusion A group presentation to research participants is an efficient method of communicating study results to those who desire to be informed and was highly valued by those who attended. Prospectively planning for such presentations and greater scheduling flexibility may result in higher attendance rates. Trial Registration Number Clinicaltrials.gov #NCT00037154

  8. Complete wind farm electromagnetic transient modelling for grid integration studies

    International Nuclear Information System (INIS)

    Zubia, I.; Ostolaza, X.; Susperregui, A.; Tapia, G.

    2009-01-01

    This paper presents a modelling methodology to analyse the impact of wind farms in surrounding networks. Based on the transient modelling of the asynchronous generator, the multi-machine model of a wind farm composed of N generators is developed. The model incorporates step-up power transformers, distribution lines and surrounding loads up to their connection to the power network. This model allows the simulation of symmetric and asymmetric short-circuits located in the distribution network and the analysis of transient stability of wind farms. It can be also used to study the islanding operation of wind farms

  9. Plasma simulation studies using multilevel physics models

    International Nuclear Information System (INIS)

    Park, W.; Belova, E.V.; Fu, G.Y.

    2000-01-01

    The question of how to proceed toward ever more realistic plasma simulation studies using ever increasing computing power is addressed. The answer presented here is the M3D (Multilevel 3D) project, which has developed a code package with a hierarchy of physics levels that resolve increasingly complete subsets of phase-spaces and are thus increasingly more realistic. The rationale for the multilevel physics models is given. Each physics level is described and examples of its application are given. The existing physics levels are fluid models (3D configuration space), namely magnetohydrodynamic (MHD) and two-fluids; and hybrid models, namely gyrokinetic-energetic-particle/MHD (5D energetic particle phase-space), gyrokinetic-particle-ion/fluid-electron (5D ion phase-space), and full-kinetic-particle-ion/fluid-electron level (6D ion phase-space). Resolving electron phase-space (5D or 6D) remains a future project. Phase-space-fluid models are not used in favor of delta f particle models. A practical and accurate nonlinear fluid closure for noncollisional plasmas seems not likely in the near future

  10. Light aircraft sound transmission studies - Noise reduction model

    Science.gov (United States)

    Atwal, Mahabir S.; Heitman, Karen E.; Crocker, Malcolm J.

    1987-01-01

    Experimental tests conducted on the fuselage of a single-engine Piper Cherokee light aircraft suggest that the cabin interior noise can be reduced by increasing the transmission loss of the dominant sound transmission paths and/or by increasing the cabin interior sound absorption. The validity of using a simple room equation model to predict the cabin interior sound-pressure level for different fuselage and exterior sound field conditions is also presented. The room equation model is based on the sound power flow balance for the cabin space and utilizes the measured transmitted sound intensity data. The room equation model predictions were considered good enough to be used for preliminary acoustical design studies.

  11. Behavioural Present Value Defined as Fuzzy Number – a New Approach

    Directory of Open Access Journals (Sweden)

    Piasecki Krzysztof

    2015-12-01

    Full Text Available The behavioural present value is defined as a fuzzy number assessed under the impact of chosen behavioural factors. The first formal model turned out to be burdened with some formal defects which are finally corrected in the presented article. In this way a new modified formal model of a behavioural present value is obtained. New model of the behavioural present value is used to explain the phenomenon of market equilibrium on the efficient financial market remaining in the state of financial imbalance. These considerations are illustrated by means of extensive numerical case study.

  12. Inferring the past and present connectivity across the range of a North American leaf beetle: combining ecological niche modeling and a geographically explicit model of coalescence.

    Science.gov (United States)

    Dellicour, Simon; Fearnley, Shannon; Lombal, Anicée; Heidl, Sarah; Dahlhoff, Elizabeth P; Rank, Nathan E; Mardulyn, Patrick

    2014-08-01

    The leaf beetle Chrysomela aeneicollis occurs across Western North America, either at high elevation or in small, isolated populations along the coast, and thus has a highly fragmented distribution. DNA sequence data (three loci) were collected from five regions across the species range. Population connectivity was examined using traditional ecological niche modeling, which suggested that gene flow could occur among regions now and in the past. We developed geographically explicit coalescence models of sequence evolution that incorporated a two-dimensional representation of the hypothesized ranges suggested by the niche-modeling estimates. We simulated sequence data according to these models and compared them to observed sequences to identify most probable scenarios regarding the migration history of C. aeneicollis. Our results disagreed with initial niche-modeling estimates by clearly rejecting recent connectivity among regions, and were instead most consistent with a long period of range fragmentation, extending well beyond the last glacial maximum. This application of geographically explicit models of coalescence has highlighted some limitations of the use of climatic variables for predicting the present and past range of a species and has explained aspects of the Pleistocene evolutionary history of a cold-adapted organism in Western North America. © 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.

  13. Studies of Monte Carlo Modelling of Jets at ATLAS

    CERN Document Server

    Kar, Deepak; The ATLAS collaboration

    2017-01-01

    The predictions of different Monte Carlo generators for QCD jet production, both in multijets and for jets produced in association with other objects, are presented. Recent improvements in showering Monte Carlos provide new tools for assessing systematic uncertainties associated with these jets.  Studies of the dependence of physical observables on the choice of shower tune parameters and new prescriptions for assessing systematic uncertainties associated with the choice of shower model and tune are presented.

  14. Economic burden of torture for a refugee host country: development of a model and presentation of a country case study

    Directory of Open Access Journals (Sweden)

    Mpinga EK

    2014-04-01

    Full Text Available Emmanuel Kabengele Mpinga,1,* Conrad Frey,2,* Philippe Chastonay1,*1Institute of Social and Preventive Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland; 2Psychiatric Clinic, Obwalden Cantonal Hospital, Sarnen, Switzerland*These authors contributed equally to this workBackground: Torture is an important social and political problem worldwide that affects millions of people. Many host countries give victims of torture the status of refugee and take care of them as far as basic needs; health care, professional reinsertion, and education. Little is known about the costs of torture. However, this knowledge could serve as an additional argument for the prevention and social mobilization to fight against torture and to provide a powerful basis of advocacy for rehabilitation programs and judiciary claims.Objectives: Development of a model for estimating the economic costs of torture and applying the model to a specific country.Methods: The estimation of the possible prevalence of victims of torture was based on a review of the literature. The identification of the socioeconomic factors to be considered was done by analogy with various health problems. The estimation of the loss of the productivity and of the economic burden of disease related to torture was done through the human capital approach and the component technique analysis.Case study: The model was applied to the situation in Switzerland of estimated torture victims Switzerland is confronted with.Results: When applied to the case study, the direct costs – such as housing, food, and clothing – represent roughly 130 million Swiss francs (CHF per year; whereas, health care costs amount to 16 million CHF per year, and the costs related to education of young people to 34 million CHF per year. Indirect costs, namely those costs related to the loss of the productivity of direct survivors of torture, have been estimated to one-third of 1 billion CHF per year. This jumps to

  15. Modeling of environmentally significant interfaces: Two case studies

    International Nuclear Information System (INIS)

    Williford, R.E.

    2006-01-01

    When some parameters cannot be easily measured experimentally, mathematical models can often be used to deconvolute or interpret data collected on complex systems, such as those characteristic of many environmental problems. These models can help quantify the contributions of various physical or chemical phenomena that contribute to the overall behavior, thereby enabling the scientist to control and manipulate these phenomena, and thus to optimize the performance of the material or device. In the first case study presented here, a model is used to test the hypothesis that oxygen interactions with hydrogen on the catalyst particles of solid oxide fuel cell anodes can sometimes occur a finite distance away from the triple phase boundary (TPB), so that such reactions are not restricted to the TPB as normally assumed. The model may help explain a discrepancy between the observed structure of SOFCs and their performance. The second case study develops a simple physical model that allows engineers to design and control the sizes and shapes of mesopores in silica thin films. Such pore design can be useful for enhancing the selectivity and reactivity of environmental sensors and catalysts. This paper demonstrates the mutually beneficial interactions between experiment and modeling in the solution of a wide range of problems

  16. Biomimetic agent based modelling using male Frog calling behaviour as a case study

    DEFF Research Database (Denmark)

    Jørgensen, Søren V.; Demazeau, Yves; Christensen-Dalsgaard, Jakob

    2014-01-01

    by individuals to generate their observed population behaviour. A number of existing agent-modelling frameworks are considered, but none have the ability to handle large numbers of time-dependent event-generating agents; hence the construction of a new tool, RANA. The calling behaviour of the Puerto Rican Tree...... Frog, E. coqui, is implemented as a case study for the presentation and discussion of the tool, and results from this model are presented. RANA, in its present stage of development, is shown to be able to handle the problem of modelling calling frogs, and several fruitful extensions are proposed...

  17. Model validation studies of solar systems, Phase III. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, L.J.; Winn, C.B.

    1978-12-01

    Results obtained from a validation study of the TRNSYS, SIMSHAC, and SOLCOST solar system simulation and design are presented. Also included are comparisons between the FCHART and SOLCOST solar system design programs and some changes that were made to the SOLCOST program. Finally, results obtained from the analysis of several solar radiation models are presented. Separate abstracts were prepared for ten papers.

  18. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 2: Papers and presentations

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, R.L.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process -- and how -- would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies, or exercises. The conference proceedings consist of three volumes. Volume 1 contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and panels. This volume contains a short introduction and the papers and presentations from the conference. Volume 3 contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.). Individual papers in this volume were abstracted and indexed for the database.

  19. Present studies on the radio-sterilized drugs

    International Nuclear Information System (INIS)

    Marciniec, B.; Dettlaff, K.

    2007-01-01

    Lecture presents present status of radiosterilization of drugs and medical materials as compared to other sterilization methods. Literature review is shown on degradation of different kinds of drugs sterilized upon action of the sterilising doses of radiation

  20. An experimental and modeling study of n-octanol combustion

    KAUST Repository

    Cai, Liming

    2015-01-01

    This study presents the first investigation on the combustion chemistry of n-octanol, a long chain alcohol. Ignition delay times were determined experimentally in a high-pressure shock tube, and stable species concentration profiles were obtained in a jet stirred reactor for a range of initial conditions. A detailed kinetic model was developed to describe the oxidation of n-octanol at both low and high temperatures, and the model shows good agreement with the present dataset. The fuel\\'s combustion characteristics are compared to those of n-alkanes and to short chain alcohols to illustrate the effects of the hydroxyl moiety and the carbon chain length on important combustion properties. Finally, the results are discussed in detail. © 2014 The Combustion Institute.

  1. Modeling extracellular matrix (ECM) alterations in ovarian cancer by multiphoton excited fabrication of stromal models (Conference Presentation)

    Science.gov (United States)

    Campagnola, Paul J.; Ajeti, Visar; Lara, Jorge; Eliceiri, Kevin W.; Patankar, Mansh

    2016-04-01

    A profound remodeling of the extracellular matrix (ECM) occurs in human ovarian cancer but it unknown how this affects tumor growth, where this understanding could lead to better diagnostics and therapeutic approaches. We investigate the role of these ECM alterations by using multiphoton excited (MPE) polymerization to fabricate biomimetic models to investigate operative cell-matrix interactions in invasion/metastasis. First, we create nano/microstructured gradients mimicking the basal lamina to study adhesion/migration dynamics of ovarian cancer cells of differing metastatic potential. We find a strong haptotactic response that depends on both contact guidance and ECM binding cues. While we found enhanced migration for more invasive cells, the specifics of alignment and directed migration also depend on cell polarity. We further use MPE fabrication to create collagen scaffolds with complex, 3D submicron morphology. The stromal scaffold designs are derived directly from "blueprints" based on SHG images of normal, high risk, and malignant ovarian tissues. The models are seeded with different cancer cell lines and this allows decoupling of the roles of cell characteristics (metastatic potential) and ECM structure and composition (normal vs cancer) on adhesion/migration dynamics. We found the malignant stroma structure promotes enhanced migration and proliferation and also cytoskeletal alignment. Creating synthetic models based on fibers patterns further allows decoupling the topographic roles of the fibers themselves vs their alignment within the tissue. These models cannot be synthesized by other conventional fabrication methods and we suggest the MPE image-based fabrication method will enable a variety of studies in cancer biology.

  2. A novel 3D skin explant model to study anaerobic bacterial infection

    DEFF Research Database (Denmark)

    Maboni, Grazieli; Davenport, Rebecca; Sessford, Kate

    2017-01-01

    of the tissue structure and the cell types present in the host environment. A 3D skin culture model can be set up using tissues acquired from surgical procedures or post slaughter, making it a cost effective and attractive alternative to animal experimentation. The majority of 3D culture models have been......Skin infection studies are often limited by financial and ethical constraints, and alternatives, such as monolayer cell culture, do not reflect many cellular processes limiting their application. For a more functional replacement, 3D skin culture models offer many advantages such as the maintenance...... bacterium and the causative agent of footrot. The mechanism of infection and host immune response to D. nodosus is poorly understood. Here we present a novel 3D skin ex vivo model to study anaerobic bacterial infections using ovine skin explants infected with D. nodosus. Our results demonstrate that D...

  3. Mappings From Models Presenting Topological Mass Mechanisms to Purely Topological Models

    International Nuclear Information System (INIS)

    Amaral, R.L.P.G.; Costa, J.V.; Ventura, O.S.; Bouffon, L.O.; Lemes, V.E.R.

    2004-01-01

    We discuss a class of mappings between the fields of the Cremmer-Sherk and pure BF model in 4D. These mappings are established both with an iterative procedure as well as with an exact mapping procedure. Related equivalences in 5D and 3D are discussed

  4. Looking beyond general metrics for model comparison - lessons from an international model intercomparison study

    Science.gov (United States)

    de Boer-Euser, Tanja; Bouaziz, Laurène; De Niel, Jan; Brauer, Claudia; Dewals, Benjamin; Drogue, Gilles; Fenicia, Fabrizio; Grelier, Benjamin; Nossent, Jiri; Pereira, Fernando; Savenije, Hubert; Thirel, Guillaume; Willems, Patrick

    2017-01-01

    International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although model comparison studies are very valuable for international cooperation, they do often not lead to very clear new insights regarding the relevance of the modelled processes. We hypothesise that this is partly caused by model complexity and the comparison methods used, which focus too much on a good overall performance instead of focusing on a variety of specific events. In this study, we use an approach that focuses on the evaluation of specific events and characteristics. Eight international research groups calibrated their hourly model on the Ourthe catchment in Belgium and carried out a validation in time for the Ourthe catchment and a validation in space for nested and neighbouring catchments. The same protocol was followed for each model and an ensemble of best-performing parameter sets was selected. Although the models showed similar performances based on general metrics (i.e. the Nash-Sutcliffe efficiency), clear differences could be observed for specific events. We analysed the hydrographs of these specific events and conducted three types of statistical analyses on the entire time series: cumulative discharges, empirical extreme value distribution of the peak flows and flow duration curves for low flows. The results illustrate the relevance of including a very quick flow reservoir preceding the root zone storage to model peaks during low flows and including a slow reservoir in parallel with the fast reservoir to model the recession for the studied catchments. This intercomparison enhanced the understanding of the hydrological functioning of the catchment, in particular for low flows, and enabled to identify present knowledge gaps for other parts of the hydrograph. Above all, it helped to evaluate each model against a set of alternative models.

  5. Mappings from models presenting topological mass mechanisms to purely topological models

    International Nuclear Information System (INIS)

    Amaral, R.L.P.G.; Costa, J.V.; Bouffon, L.O.; Lemes, V.E.R.

    2004-01-01

    We discuss a class of mappings between the fields of the Cremmer-Sherk and pure BF model in 4D. These mappings are established both with an interactive procedure as well as with an exact mapping procedure. Related equivalencies in 5D and 3D are discussed. (author)

  6. Shell-model Monte Carlo studies of nuclei

    International Nuclear Information System (INIS)

    Dean, D.J.

    1997-01-01

    The pair content and structure of nuclei near N = Z are described in the frwnework of shell-model Monte Carlo (SMMC) calculations. Results include the enhancement of J=0 T=1 proton-neutron pairing at N=Z nuclei, and the maxked difference of thermal properties between even-even and odd-odd N=Z nuclei. Additionally, a study of the rotational properties of the T=1 (ground state), and T=0 band mixing seen in 74 Rb is presented

  7. Immune Cell-Supplemented Human Skin Model for Studying Fungal Infections.

    Science.gov (United States)

    Kühbacher, Andreas; Sohn, Kai; Burger-Kentischer, Anke; Rupp, Steffen

    2017-01-01

    Human skin is a niche for various fungal species which either colonize the surface of this tissue as commensals or, primarily under conditions of immunosuppression, invade the skin and cause infection. Here we present a method for generation of a human in vitro skin model supplemented with immune cells of choice. This model represents a complex yet amenable tool to study molecular mechanisms of host-fungi interactions at human skin.

  8. Plasma simulation studies using multilevel physics models

    International Nuclear Information System (INIS)

    Park, W.; Belova, E.V.; Fu, G.Y.; Tang, X.Z.; Strauss, H.R.; Sugiyama, L.E.

    1999-01-01

    The question of how to proceed toward ever more realistic plasma simulation studies using ever increasing computing power is addressed. The answer presented here is the M3D (Multilevel 3D) project, which has developed a code package with a hierarchy of physics levels that resolve increasingly complete subsets of phase-spaces and are thus increasingly more realistic. The rationale for the multilevel physics models is given. Each physics level is described and examples of its application are given. The existing physics levels are fluid models (3D configuration space), namely magnetohydrodynamic (MHD) and two-fluids; and hybrid models, namely gyrokinetic-energetic-particle/MHD (5D energetic particle phase-space), gyrokinetic-particle-ion/fluid-electron (5D ion phase-space), and full-kinetic-particle-ion/fluid-electron level (6D ion phase-space). Resolving electron phase-space (5D or 6D) remains a future project. Phase-space-fluid models are not used in favor of δf particle models. A practical and accurate nonlinear fluid closure for noncollisional plasmas seems not likely in the near future. copyright 1999 American Institute of Physics

  9. Bonissone CIDU Presentation: Design of Local Fuzzy Models

    Data.gov (United States)

    National Aeronautics and Space Administration — After reviewing key background concepts in fuzzy systems and evolutionary computing, we will focus on the use of local fuzzy models, which are related to both kernel...

  10. Wind Turbine and Wind Power Plant Modelling Aspects for Power System Stability Studies

    DEFF Research Database (Denmark)

    Altin, Müfit; Hansen, Anca Daniela; Göksu, Ömer

    2014-01-01

    Large amount of wind power installations introduce modeling challenges for power system operators at both the planning and operational stages of power systems. Depending on the scope of the study, the modeling details of the wind turbine or the wind power plant are required to be different. A wind...... turbine model which is developed for the short-term voltage stability studies can be inaccurate and sufficient for the frequency stability studies. Accordingly, a complete and detailed wind power plant model for every kind of study is not feasible in terms of the computational time and also...... and wind power plants are reviewed for power system stability studies. Important remarks of the models are presented by means of simulations to emphasize the impact of these modelling details on the power system....

  11. Overview of the reactor safety study consequence model

    International Nuclear Information System (INIS)

    Wall, I.B.; Yaniv, S.S.; Blond, R.M.; McGrath, P.E.; Church, H.W.; Wayland, J.R.

    1977-01-01

    The Reactor Safety Study (WASH-1400) is a comprehensive assessment of the potential risk to the public from accidents in light water power reactors. The engineering analysis of the plants is described in detail in the Reactor Safety Study: it provides an estimate of the probability versus magnitude of the release of radioactive material. The consequence model, which is the subject of this paper, describes the progression of the postulated accident after the release of the radioactive material from the containment. A brief discussion of the manner in which the consequence calculations are performed is presented. The emphasis in the description is on the models and data that differ significantly from those previously used for these types of assessments. The results of the risk calculations for 100 light water power reactors are summarized

  12. Study on high-level waste geological disposal metadata model

    International Nuclear Information System (INIS)

    Ding Xiaobin; Wang Changhong; Zhu Hehua; Li Xiaojun

    2008-01-01

    This paper expatiated the concept of metadata and its researches within china and abroad, then explain why start the study on the metadata model of high-level nuclear waste deep geological disposal project. As reference to GML, the author first set up DML under the framework of digital underground space engineering. Based on DML, a standardized metadata employed in high-level nuclear waste deep geological disposal project is presented. Then, a Metadata Model with the utilization of internet is put forward. With the standardized data and CSW services, this model may solve the problem in the data sharing and exchanging of different data form A metadata editor is build up in order to search and maintain metadata based on this model. (authors)

  13. Studies on DANESS Code Modeling

    International Nuclear Information System (INIS)

    Jeong, Chang Joon

    2009-09-01

    The DANESS code modeling study has been performed. DANESS code is widely used in a dynamic fuel cycle analysis. Korea Atomic Energy Research Institute (KAERI) has used the DANESS code for the Korean national nuclear fuel cycle scenario analysis. In this report, the important models such as Energy-demand scenario model, New Reactor Capacity Decision Model, Reactor and Fuel Cycle Facility History Model, and Fuel Cycle Model are investigated. And, some models in the interface module are refined and inserted for Korean nuclear fuel cycle model. Some application studies have also been performed for GNEP cases and for US fast reactor scenarios with various conversion ratios

  14. Model performance evaluation (validation and calibration) in model-based studies of therapeutic interventions for cardiovascular diseases : a review and suggested reporting framework.

    Science.gov (United States)

    Haji Ali Afzali, Hossein; Gray, Jodi; Karnon, Jonathan

    2013-04-01

    Decision analytic models play an increasingly important role in the economic evaluation of health technologies. Given uncertainties around the assumptions used to develop such models, several guidelines have been published to identify and assess 'best practice' in the model development process, including general modelling approach (e.g., time horizon), model structure, input data and model performance evaluation. This paper focuses on model performance evaluation. In the absence of a sufficient level of detail around model performance evaluation, concerns regarding the accuracy of model outputs, and hence the credibility of such models, are frequently raised. Following presentation of its components, a review of the application and reporting of model performance evaluation is presented. Taking cardiovascular disease as an illustrative example, the review investigates the use of face validity, internal validity, external validity, and cross model validity. As a part of the performance evaluation process, model calibration is also discussed and its use in applied studies investigated. The review found that the application and reporting of model performance evaluation across 81 studies of treatment for cardiovascular disease was variable. Cross-model validation was reported in 55 % of the reviewed studies, though the level of detail provided varied considerably. We found that very few studies documented other types of validity, and only 6 % of the reviewed articles reported a calibration process. Considering the above findings, we propose a comprehensive model performance evaluation framework (checklist), informed by a review of best-practice guidelines. This framework provides a basis for more accurate and consistent documentation of model performance evaluation. This will improve the peer review process and the comparability of modelling studies. Recognising the fundamental role of decision analytic models in informing public funding decisions, the proposed

  15. Prospective validation of a predictive model that identifies homeless people at risk of re-presentation to the emergency department.

    Science.gov (United States)

    Moore, Gaye; Hepworth, Graham; Weiland, Tracey; Manias, Elizabeth; Gerdtz, Marie Frances; Kelaher, Margaret; Dunt, David

    2012-02-01

    To prospectively evaluate the accuracy of a predictive model to identify homeless people at risk of representation to an emergency department. A prospective cohort analysis utilised one month of data from a Principal Referral Hospital in Melbourne, Australia. All visits involving people classified as homeless were included, excluding those who died. Homelessness was defined as living on the streets, in crisis accommodation, in boarding houses or residing in unstable housing. Rates of re-presentation, defined as the total number of visits to the same emergency department within 28 days of discharge from hospital, were measured. Performance of the risk screening tool was assessed by calculating sensitivity, specificity, positive and negative predictive values and likelihood ratios. Over the study period (April 1, 2009 to April 30, 2009), 3298 presentations from 2888 individuals were recorded. The homeless population accounted for 10% (n=327) of all visits and 7% (n=211) of all patients. A total of 90 (43%) homeless people re-presented to the emergency department. The predictive model included nine variables and achieved 98% (CI, 0.92-0.99) sensitivity and 66% (CI, 0.57-0.74) specificity. The positive predictive value was 68% and the negative predictive value was 98%. The positive likelihood ratio 2.9 (CI, 2.2-3.7) and the negative likelihood ratio was 0.03 (CI, 0.01-0.13). The high emergency department re-presentation rate for people who were homeless identifies unresolved psychosocial health needs. The emergency department remains a vital access point for homeless people, particularly after hours. The risk screening tool is key to identify medical and social aspects of a homeless patient's presentation to assist early identification and referral. Copyright © 2012 College of Emergency Nursing Australasia Ltd. Published by Elsevier Ltd. All rights reserved.

  16. A Collective Case Study of Secondary Students' Model-Based Inquiry on Natural Selection through Programming in an Agent-Based Modeling Environment

    Science.gov (United States)

    Xiang, Lin

    2011-01-01

    This is a collective case study seeking to develop detailed descriptions of how programming an agent-based simulation influences a group of 8th grade students' model-based inquiry (MBI) by examining students' agent-based programmable modeling (ABPM) processes and the learning outcomes. The context of the present study was a biology unit on…

  17. Foresight Model of Turkey's Defense Industries' Space Studies until 2040

    Science.gov (United States)

    Yuksel, Nurdan; Cifci, Hasan; Cakir, Serhat

    2016-07-01

    Being advanced in science and technology is inevitable reality in order to be able to have a voice in the globalized world. Therefore, for the countries, making policies in consistent with their societies' intellectual, economic and political infrastructure and attributing them to the vision having been embraced by all parties of the society is quite crucial for the success. The generated policies are supposed to ensure the usage of countries' resources in the most effective and fastest way, determine the priorities and needs of society and set their goals and related roadmaps. In this sense, technology foresight studies based on justified forecasting in science and technology have critical roles in the process of developing policies. In this article, Foresight Model of Turkey's Defense Industries' Space Studies, which is turned out to be the important part of community life and fundamental background of most technologies, up to 2040 is presented. Turkey got late in space technology studies. Hence, for being fast and efficient to use its national resources in a cost effective way and within national and international collaboration, it should be directed to its pre-set goals. By taking all these factors into consideration, the technology foresight model of Turkey's Defense Industry's Space Studies was presented in the study. In the model, the present condition of space studies in the World and Turkey was analyzed; literature survey and PEST analysis were made. PEST analysis will be the inputs of SWOT analysis and Delphi questionnaire will be used in the study. A two-round Delphi survey will be applied to the participants from universities, public and private organizations operating in space studies at Defense Industry. Critical space technologies will be distinguished according to critical technology measures determined by expert survey; space technology fields and goals will be established according to their importance and feasibility indexes. Finally, for the

  18. A study on an optimal movement model

    Energy Technology Data Exchange (ETDEWEB)

    Feng Jianfeng [COGS, Sussex University, Brighton BN1 9QH, UK (United Kingdom); Zhang, Kewei [SMS, Sussex University, Brighton BN1 9QH (United Kingdom); Luo Yousong [Department of Mathematics and Statistics, RMIT University, GOP Box 2476V, Melbourne, Vic 3001 (Australia)

    2003-07-11

    We present an analytical and rigorous study on a TOPS (task optimization in the presence of signal-dependent noise) model with a hold-on or an end-point control. Optimal control signals are rigorously obtained, which enables us to investigate various issues about the model including its trajectories, velocities, control signals, variances and the dependence of these quantities on various model parameters. With the hold-on control, we find that the optimal control can be implemented with an almost 'nil' hold-on period. The optimal control signal is a linear combination of two sub-control signals. One of the sub-control signals is positive and the other is negative. With the end-point control, the end-point variance is dramatically reduced, in comparison with the hold-on control. However, the velocity is not symmetric (bell shape). Finally, we point out that the velocity with a hold-on control takes the bell shape only within a limited parameter region.

  19. The radiation performance standard. A presentation model for ionizing radiation in the living environment

    International Nuclear Information System (INIS)

    Schaap, L.E.J.J.; Bosmans, G.; Van der Graaf, E.R.; Hendriks, Ch.F.

    1998-01-01

    By means of the so-called radiation performance standard (SPN, abbreviated in Dutch) the total radioactivity from building constructions which contributes to the indoor radiation dose can be calculated. The SPN is implemented with related boundary values and is part of the Building Decree ('Bouwbesluit') in the Netherlands. The model, presented in this book, forms the basis of a new Dutch radiation protection standard, to be published by the Dutch Institute for Standardization NEN (formerly NNI). 14 refs

  20. Rapid State Space Modeling Tool for Rectangular Wing Aeroservoelastic Studies

    Science.gov (United States)

    Suh, Peter M.; Conyers, Howard Jason; Mavris, Dimitri N.

    2015-01-01

    This report introduces a modeling and simulation tool for aeroservoelastic analysis of rectangular wings with trailing-edge control surfaces. The inputs to the code are planform design parameters such as wing span, aspect ratio, and number of control surfaces. Using this information, the generalized forces are computed using the doublet-lattice method. Using Roger's approximation, a rational function approximation is computed. The output, computed in a few seconds, is a state space aeroservoelastic model which can be used for analysis and control design. The tool is fully parameterized with default information so there is little required interaction with the model developer. All parameters can be easily modified if desired. The focus of this report is on tool presentation, verification, and validation. These processes are carried out in stages throughout the report. The rational function approximation is verified against computed generalized forces for a plate model. A model composed of finite element plates is compared to a modal analysis from commercial software and an independently conducted experimental ground vibration test analysis. Aeroservoelastic analysis is the ultimate goal of this tool, therefore, the flutter speed and frequency for a clamped plate are computed using damping-versus-velocity and frequency-versus-velocity analysis. The computational results are compared to a previously published computational analysis and wind-tunnel results for the same structure. A case study of a generic wing model with a single control surface is presented. Verification of the state space model is presented in comparison to damping-versus-velocity and frequency-versus-velocity analysis, including the analysis of the model in response to a 1-cos gust.

  1. A case study of consensus modelling for tracking oil spills

    International Nuclear Information System (INIS)

    King, Brian; Brushett, Ben; Lemckert, Charles

    2010-01-01

    Metocean forecast datasets are essential for the timely response to marine incidents and pollutant spill mitigation at sea. To effectively model the likely drift pattern and the area of impact for a marine spill, both wind and ocean current forecast datasets are required. There are two ocean current forecast models and two wind forecast models currently used operationally in the Australia and Asia Pacific region. The availability of several different forecast models provides a unique opportunity to compare the outcome of a particular modelling exercise with the outcome of another using a different model and determining whether there is consensus in the results. Two recent modelling exercises, the oil spill resulting from the damaged Pacific Adventurer (in Queensland) and the oil spill from the Montara well blowout (in Western Australia) are presented as case studies to examine consensus modelling.

  2. STUDY OF CLINICAL PRESENTATIONS OF PATIENTS WITH HYPERPROLACTINAEMIA VISITING A TERTIARY CARE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Binoy Kumar Mohanty

    2016-06-01

    Full Text Available BACKGROUND Hyperprolactinaemia is one of the common endocrine disorders seen in clinical practice. It may result due to various causes and elucidating the exact cause is necessary to formulate the right therapy. OBJECTIVE To study the various aetiologies and clinical presentation of patients presenting with hyperprolactinaemia to a tertiary care hospital. DESIGN Cross-sectional study. MATERIAL AND METHODS We collected and analysed the clinical data including hormonal status of 74 consecutive patients who presented to our department from June 2015 to May 2016 for evaluation of hyperprolactinaemia. RESULTS Majority of the subjects studied belonged to 20-29 years group (47.29% followed by 30-39 years age group (24.32%. The most common cause in our population was due to drug-induced causes (35.13%. The next common causes included idiopathic group (20.4% followed by pituitary adenomas (16.21%. There was significant female predominance (83.78% among total cases. Among women who presented with hyperprolactinaemia, menstrual irregularity (69.35% followed by galactorrhoea (35.48% were the most common presentations. CONCLUSIONS Hyperprolactinaemia is frequently seen among women who presented with either menstrual irregularity or galactorrhoea or both. Drug-induced hyperprolactinaemia is the most common cause seen in our study population.

  3. Ecoclimatic indicators to study crop suitability in present and future climatic conditionsTIC CONDITIONS

    Science.gov (United States)

    Caubel, Julie; Garcia de Cortazar Atauri, Inaki; Huard, Frédéric; Launay, Marie; Ripoche, Dominique; Gouache, David; Bancal, Marie-Odile; Graux, Anne-Isabelle; De Noblet, Nathalie

    2013-04-01

    Climate change is expected to affect both regional and global food production through changes in overall agroclimatic conditions. It is therefore necessary to develop simple tools of crop suitability diagnosis in a given area so that stakeholders can envisage land use adaptations under climate change conditions. The most common way to investigate potential impacts of climate on the evolution of agrosystems is to make use of an array of agroclimatic indicators, which provide synthetic information derived from climatic variables and calculated within fixed periods (i.e. January first - 31th July). However, the information obtained during these periods does not enable to take account of the plant response to climate. In this work, we present some results of the research program ORACLE (Opportunities and Risks of Agrosystems & forests in response to CLimate, socio-economic and policy changEs in France (and Europe). We proposed a suite of relevant ecoclimatic indicators, based on temperature and rainfall, in order to evaluate crop suitability for both present and new climatic conditions. Ecoclimatic indicators are agroclimatic indicators (e.g., grain heat stress) calculated during specific phenological phases so as to take account of the plant response to climate (e.g., the grain filling period, flowering- harvest). These indicators are linked with the ecophysiological processes they characterize (for e.g., the grain filling). To represent this methodology, we studied the suitability of winter wheat in future climatic conditions through three distinct French sites, Toulouse, Dijon and Versailles. Indicators have been calculated using climatic data from 1950 to 2100 simulated by the global climate model ARPEGE forced by a greenhouse effect corresponding to the SRES A1B scenario. The Quantile-Quantile downscaling method was applied to obtain data for the three locations. Phenological stages (emergence, ear 1 cm, flowering, beginning of grain filling and harvest) have been

  4. A case study to estimate costs using Neural Networks and regression based models

    Directory of Open Access Journals (Sweden)

    Nadia Bhuiyan

    2012-07-01

    Full Text Available Bombardier Aerospace’s high performance aircrafts and services set the utmost standard for the Aerospace industry. A case study in collaboration with Bombardier Aerospace is conducted in order to estimate the target cost of a landing gear. More precisely, the study uses both parametric model and neural network models to estimate the cost of main landing gears, a major aircraft commodity. A comparative analysis between the parametric based model and those upon neural networks model will be considered in order to determine the most accurate method to predict the cost of a main landing gear. Several trials are presented for the design and use of the neural network model. The analysis for the case under study shows the flexibility in the design of the neural network model. Furthermore, the performance of the neural network model is deemed superior to the parametric models for this case study.

  5. Basic models modeling resistance training: an update for basic scientists interested in study skeletal muscle hypertrophy.

    Science.gov (United States)

    Cholewa, Jason; Guimarães-Ferreira, Lucas; da Silva Teixeira, Tamiris; Naimo, Marshall Alan; Zhi, Xia; de Sá, Rafaele Bis Dal Ponte; Lodetti, Alice; Cardozo, Mayara Quadros; Zanchi, Nelo Eidy

    2014-09-01

    Human muscle hypertrophy brought about by voluntary exercise in laboratorial conditions is the most common way to study resistance exercise training, especially because of its reliability, stimulus control and easy application to resistance training exercise sessions at fitness centers. However, because of the complexity of blood factors and organs involved, invasive data is difficult to obtain in human exercise training studies due to the integration of several organs, including adipose tissue, liver, brain and skeletal muscle. In contrast, studying skeletal muscle remodeling in animal models are easier to perform as the organs can be easily obtained after euthanasia; however, not all models of resistance training in animals displays a robust capacity to hypertrophy the desired muscle. Moreover, some models of resistance training rely on voluntary effort, which complicates the results observed when animal models are employed since voluntary capacity is something theoretically impossible to measure in rodents. With this information in mind, we will review the modalities used to simulate resistance training in animals in order to present to investigators the benefits and risks of different animal models capable to provoke skeletal muscle hypertrophy. Our second objective is to help investigators analyze and select the experimental resistance training model that best promotes the research question and desired endpoints. © 2013 Wiley Periodicals, Inc.

  6. Critical review of the reactor-safety study radiological health effects model. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, D.W.; Evans, J.S.; Jacob, N.; Kase, K.R.; Maletskos, C.J.; Robertson, J.B.; Smith, D.G.

    1983-03-01

    This review of the radiological health effects models originally presented in the Reactor Safety Study (RSS) and currently used by the US Nuclear Regulatory Commission (NRC) was undertaken to assist the NRC in determining whether or not to revise the models and to aid in the revision, if undertaken. The models as presented in the RSS and as implemented in the CRAC (Calculations of Reactor Accident Consequences) Code are described and critiqued. The major elements analyzed are those concerning dosimetry, early effects, and late effects. The published comments on the models are summarized, as are the important findings since the publication of the RSS.

  7. Critical review of the reactor-safety study radiological health effects model. Final report

    International Nuclear Information System (INIS)

    Cooper, D.W.; Evans, J.S.; Jacob, N.; Kase, K.R.; Maletskos, C.J.; Robertson, J.B.; Smith, D.G.

    1983-03-01

    This review of the radiological health effects models originally presented in the Reactor Safety Study (RSS) and currently used by the US Nuclear Regulatory Commission (NRC) was undertaken to assist the NRC in determining whether or not to revise the models and to aid in the revision, if undertaken. The models as presented in the RSS and as implemented in the CRAC (Calculations of Reactor Accident Consequences) Code are described and critiqued. The major elements analyzed are those concerning dosimetry, early effects, and late effects. The published comments on the models are summarized, as are the important findings since the publication of the RSS

  8. A test-bed modeling study for wave resource assessment

    Science.gov (United States)

    Yang, Z.; Neary, V. S.; Wang, T.; Gunawan, B.; Dallman, A.

    2016-02-01

    Hindcasts from phase-averaged wave models are commonly used to estimate standard statistics used in wave energy resource assessments. However, the research community and wave energy converter industry is lacking a well-documented and consistent modeling approach for conducting these resource assessments at different phases of WEC project development, and at different spatial scales, e.g., from small-scale pilot study to large-scale commercial deployment. Therefore, it is necessary to evaluate current wave model codes, as well as limitations and knowledge gaps for predicting sea states, in order to establish best wave modeling practices, and to identify future research needs to improve wave prediction for resource assessment. This paper presents the first phase of an on-going modeling study to address these concerns. The modeling study is being conducted at a test-bed site off the Central Oregon Coast using two of the most widely-used third-generation wave models - WaveWatchIII and SWAN. A nested-grid modeling approach, with domain dimension ranging from global to regional scales, was used to provide wave spectral boundary condition to a local scale model domain, which has a spatial dimension around 60km by 60km and a grid resolution of 250m - 300m. Model results simulated by WaveWatchIII and SWAN in a structured-grid framework are compared to NOAA wave buoy data for the six wave parameters, including omnidirectional wave power, significant wave height, energy period, spectral width, direction of maximum directionally resolved wave power, and directionality coefficient. Model performance and computational efficiency are evaluated, and the best practices for wave resource assessments are discussed, based on a set of standard error statistics and model run times.

  9. Parametric study of a turbocompound diesel engine based on an analytical model

    International Nuclear Information System (INIS)

    Zhao, Rongchao; Zhuge, Weilin; Zhang, Yangjun; Yin, Yong; Zhao, Yanting; Chen, Zhen

    2016-01-01

    Turbocompounding is an important technique to recover waste heat from engine exhaust and reduce CO_2 emission. This paper presents a parametric study of turbocompound diesel engine based on analytical model. An analytical model was developed to investigate the influence of system parameters on the engine fuel consumption. The model is based on thermodynamics knowledge and empirical models, which can consider the impacts of each parameter independently. The effects of turbine efficiency, back pressure, exhaust temperature, pressure ratio and engine speed on the recovery energy, pumping loss and engine fuel reductions were studied. Results show that turbine efficiency, exhaust temperature and back pressure has great influence on the fuel reduction and optimal power turbine (PT) expansion ratio. However, engine operation speed has little impact on the fuel savings obtained by turbocompounding. The interaction mechanism between the PT recovery power and engine pumping loss is presented in the paper. Due to the nonlinear characteristic of turbine power, there is an optimum value of PT expansion ratio to achieve largest power gain. At the end, the fuel saving potential of high performance turbocompound engine and the requirements for it are proposed in the paper. - Highlights: • An analytical model for turbocompound engine is developed and validated. • Parametric study is performed to obtain lowest BSFC and optimal expansion ratio. • The influences of each parameter on the fuel saving potentials are presented. • The impact mechanisms of each parameter on the energy tradeoff are disclosed. • It provides an effective tool to guide the preliminary design of turbocompounding.

  10. A study of composite models at LEP with ALEPH

    International Nuclear Information System (INIS)

    Badaud, F.

    1992-04-01

    Tests of composite models are performed in e + e - collisions in the vicinity of the Z 0 pole using the ALEPH detector. Two kinds of substructure effects are searched for: deviations of differential cross section for reactions e + e - → l + l - and e + e - → γ γ from standard model predictions, and direct search for excited neutrino. A new interaction, parametrized by a 4-fermion contact term, cell, is studied in lepton pair production reactions, assuming different chiralities of the currents. Lower limits on the compositeness scale Λ are obtained by fitting model predictions to the data. They are in the range from 1 to a few TeV depending on model and lepton flavour. Researches for the lightest excited particle that could be the excited neutrino, are presented

  11. Using Model-Based System Engineering to Provide Artifacts for NASA Project Life-Cycle and Technical Reviews Presentation

    Science.gov (United States)

    Parrott, Edith L.; Weiland, Karen J.

    2017-01-01

    This is the presentation for the AIAA Space conference in September 2017. It highlights key information from Using Model-Based Systems Engineering to Provide Artifacts for NASA Project Life-cycle and Technical Reviews paper.

  12. Presentation of the Three-ME model: Multi-sector macro-economic Model for the Evaluation of Environmental and Energy policy

    International Nuclear Information System (INIS)

    Reynes, Frederic; Yeddir-Tamsamani, Yasser; Callonnec, Gael

    2011-05-01

    This paper presents the structure and the main properties of Three-ME. This new model of the French economy has been especially designed to evaluate the medium and long term impact of environmental and energy policies at the macro-economic and sector levels. To do so Three-ME combines two important features. Firstly, it has the main characteristics of neo-Keynesian models by assuming a slow adjustment of effective quantities and prices to their notional level. Compared to standard multi-sectors CGEM, this has the advantage to allow for the existence of under-optimum equilibriums such as the presence of involuntary unemployment. Secondly, production and consumption structures are represented with a generalized CES function which allows for the elasticity of substitution to differ between each couple of inputs or goods. This is an improvement compared to the standard approach that uses nested CES functions which has the disadvantage to impose a common elasticity of substitution between the goods located in two different nested structures. (authors)

  13. Implementation of IEC standard models for power system stability studies

    Energy Technology Data Exchange (ETDEWEB)

    Margaris, Ioannis D.; Hansen, Anca D.; Soerensen, Poul [Technical Univ. of Denmark, Roskilde (Denmark). Dept. of Wind Energy; Bech, John; Andresen, Bjoern [Siemens Wind Power A/S, Brande (Denmark)

    2012-07-01

    This paper presents the implementation of the generic wind turbine generator (WTG) electrical simulation models proposed in the IEC 61400-27 standard which is currently in preparation. A general overview of the different WTG types is given while the main focus is on Type 4B WTG standard model, namely a model for a variable speed wind turbine with full scale power converter WTG including a 2-mass mechanical model. The generic models for fixed and variable speed WTGs models are suitable for fundamental frequency positive sequence response simulations during short events in the power system such as voltage dips. The general configuration of the models is presented and discussed; model implementation in the simulation software platform DIgSILENT PowerFactory is presented in order to illustrate the range of applicability of the generic models under discussion. A typical voltage dip is simulated and results from the basic electrical variables of the WTG are presented and discussed. (orig.)

  14. Full scale model studies of nuclear power stations for earthquake resistance

    International Nuclear Information System (INIS)

    Kirillov, A.P.; Ambriashvili, Ju. K.; Kozlov, A.V.

    Behaviour of nuclear power plants and its equipments under seismic action is not well understood. In the absence of well established method for aseismic deisgn of nuclear power plants and its equipments, it is necessary to carry out experimental investigations on models, fragments and full scale structures. The present study includes experimental investigations of different scale models and on existing nuclear power stations under impulse and explosion effects simulating seismic loads. The experimental work was aimed to develop on model test procedure for nuclear power station and the evaluation of the possible range of dynamic stresses in structures and pipe lines. The results of full-scale investigations of the nuclear reactor show a good agreement of dynamic characteristics of the model and the prototype. The study confirms the feasibility of simulation of model for nuclear power plants. (auth.)

  15. Buddleja thyrsoides Lam. crude extract presents antinociceptive effect on an arthritic pain model in mice.

    Science.gov (United States)

    Fialho, Maria Fernanda Pessano; Brusco, Indiara; da Silva Brum, Evelyne; Piana, Mariana; Boligon, Aline Augusti; Trevisan, Gabriela; Oliveira, Sara Marchesan

    2017-08-17

    Arthritis is a chronic inflammatory disease which reduces the life quality of affected individuals. Therapeutic tools used for treating inflammatory pain are associated with several undesirable effects. Buddleja thyrsoides Lam., known as 'Barbasco' or 'Cambara', is mostly used in several disorders and possesses antirheumatic, anti-inflammatory, and analgesic properties. Here, we investigated the antinociceptive and anti-inflammatory effects of the B. thyrsoides crude extract applied orally and topically in acute pain models and an arthritic pain model induced by complete Freund's adjuvant (CFA) paw injection in male mice (25-30 g). The high-performance liquid chromatography (HPLC) of the B. thyrsoides extract crude revealed the presence of the lupeol, stigmasterol, and β-sitosterol. The stability study of the B. thyrsoides gel did not show relevant changes at low temperatures. The oral treatment with the B. thrysoides extract prevented the capsaicin-induced spontaneous nociception and the acetic acid-induced abdominal writhing, but did not alter the thermal threshold in the tail immersion test. The B. thyrsoides antinociceptive effect was not reversed by naloxone in the capsaicin test. The B. thyrsoides oral or topical treatment reversed the CFA-induced mechanical allodynia and thermal hyperalgesia with maximum inhibition ( I max ) of 69 ± 6 and 68 ± 5% as well as 78 ± 15 and 87 ± 12%, respectively. Moreover, the topical but not oral treatment inhibited the CFA-induced cell infiltration, but did not reduce the paw edema significantly. The oral treatment with B. thyrsoides did not cause adverse effects. These findings suggest that the oral or topical treatment with B. thyrsoides presents antinociceptive actions in an arthritic pain model without causing adverse effects. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

  16. I think of Ronald Reagan: future selves in the present.

    Science.gov (United States)

    Roberts, P

    1992-01-01

    A nonlinear perspective on time (where the future exists in and affects the present) has been described by several theorists but there is little research on the extent, quality or origins of the personal future perspective. The present study examined the existence and origin of the future in the present by asking adults aged nineteen to eighty-three to: 1) project themselves into the oldest age imaginable, 2) describe their hopes and fears for that age, and 3) name role models for those hopes and fears. Data analysis revealed that length of future perspective, number of hopes and number of role models for the distant future declined with age. In addition, types of fears for the future varied with age, with older adults stressing dependency issues while younger adults reported concerns about personality and mental health. Despite age differences, most participants could name role models for both their hopes and fears for aging, but specific models were identified more often for hopes than for fears. Personalized hopes and fears for the distant future as motivators for the present are discussed.

  17. Experimental and Chemical Kinetic Modeling Study of Dimethylcyclohexane Oxidation and Pyrolysis

    KAUST Repository

    Eldeeb, Mazen A.; Jouzdani, Shirin; Wang, Zhandong; Sarathy, Mani; Akih-Kumgeh, Benjamin

    2016-01-01

    A combined experimental and chemical kinetic modeling study of the high-temperature ignition and pyrolysis of 1,3-dimethylcyclohexane (13DMCH) is presented. Ignition delay times are measured behind reflected shock waves over a temperature range

  18. A comparative study to identify a suitable model of ownership for Iran football pro league clubs

    Directory of Open Access Journals (Sweden)

    Saeed Amirnejad

    2018-01-01

    Full Text Available Today the government ownership of the professional football clubs is absolutely illogical view point. Most of sports clubs are conducted by private sector using different models of ownership all over the world. In Iran, government credits benefit was main reason that the professional sport was firstly developed by government firms and organizations. Therefore, the sports team ownership is without the professionalization standards. The present comparative study was to examine the different football club ownership structures of the top leagues and the current condition of Iran football pro league ownership and then present a suitable ownership structure of Iran football clubs to leave behind the government club ownership. Among the initial 120 scientific texts, the thirty two cases including papers, books and reports were found relevant to this study. We studied the ownership prominence and several football club models of ownership focused on stock listing model of ownership, private investor model of ownership, supporter trust model of ownership and Japan partnership model of ownership; theoretical concepts, empirical studies, main findings, strengths and weaknesses were covered in analysis procedure. According to various models of ownership in leagues and the models’ productivity in football clubs, each model of ownership considering national environmental, economic, social conditions has strengths and weaknesses. So, we cannot present a definite model of ownership for Iran football pro league clubs due to different micro-environments of Iran clubs. We need a big planning to provide a supporter-investor mixed model of ownership to Iranian clubs. Considering strengths and weaknesses in the models of ownership as well as the micro and macro environment of Iran football clubs, German model and Japan partnership model are offered as suitable ones to probable new model of ownership in Iran pro league clubs. Consequently, more studies are required

  19. A single-column model intercomparison on the stratocumulus representation in present-day and future climate

    NARCIS (Netherlands)

    Dal Gesso, S.; Van der Dussen, J.J.; Siebesma, A.P.; De Roode, S.R.; Boutle, I.A.; Kamae, Y.; Roehrig, R.; Vial, J.

    2015-01-01

    Six Single-Column Model (SCM) versions of climate models are evaluated on the basis of their representation of the dependence of the stratocumulus-topped boundary layer regime on the free tropospheric thermodynamic conditions. The study includes two idealized experiments corresponding to the

  20. The present status of the study on the validity of concurrent verbalization

    International Nuclear Information System (INIS)

    Watanabe, Megumi; Takahashi, Hideaki.

    1993-09-01

    We reviewed study on the validity of the method of verbal reports. The method of verbal reports gives us detailed information about human cognitive process as compared with observing a sequence of actions, while it is subjected to criticism for the validity as data. Ericsson and Simon proposed a model of verbalization and investigated conditions to keep verbal reports valid. Although a lot of studies quote their model as a base of adopting the method of verbal reports, verification the validity of verbal reports is incomplete because effects of verbalization is not clear. We pointed out that it is necessary to take into consideration kinds of task strategies, effects of trial repetition, effects of task difficulty to examine precisely effects of verbalization. (author)

  1. Capillary microreactors for lactic acid extraction: experimental and modelling study

    NARCIS (Netherlands)

    Susanti, Susanti; Winkelman, Jozef; Schuur, Boelo; Heeres, Hero; Yue, Jun

    2015-01-01

    Lactic acid is an important biobased chemical and, among others, is used for the production of poly-lactic acid. Down-stream processing using state of the art technology is energy intensive and leads to the formation of large amounts of salts. In this presentation, experimental and modeling studies

  2. How do humans inspect BPMN models: an exploratory study.

    Science.gov (United States)

    Haisjackl, Cornelia; Soffer, Pnina; Lim, Shao Yi; Weber, Barbara

    2018-01-01

    Even though considerable progress regarding the technical perspective on modeling and supporting business processes has been achieved, it appears that the human perspective is still often left aside. In particular, we do not have an in-depth understanding of how process models are inspected by humans, what strategies are taken, what challenges arise, and what cognitive processes are involved. This paper contributes toward such an understanding and reports an exploratory study investigating how humans identify and classify quality issues in BPMN process models. Providing preliminary answers to initial research questions, we also indicate other research questions that can be investigated using this approach. Our qualitative analysis shows that humans adapt different strategies on how to identify quality issues. In addition, we observed several challenges appearing when humans inspect process models. Finally, we present different manners in which classification of quality issues was addressed.

  3. Comparison of conventional study model measurements and 3D digital study model measurements from laser scanned dental impressions

    Science.gov (United States)

    Nugrahani, F.; Jazaldi, F.; Noerhadi, N. A. I.

    2017-08-01

    The field of orthodontics is always evolving,and this includes the use of innovative technology. One type of orthodontic technology is the development of three-dimensional (3D) digital study models that replace conventional study models made by stone. This study aims to compare the mesio-distal teeth width, intercanine width, and intermolar width measurements between a 3D digital study model and a conventional study model. Twelve sets of upper arch dental impressions were taken from subjects with non-crowding teeth. The impressions were taken twice, once with alginate and once with polivinylsiloxane. The alginate impressions used in the conventional study model and the polivinylsiloxane impressions were scanned to obtain the 3D digital study model. Scanning was performed using a laser triangulation scanner device assembled by the School of Electrical Engineering and Informatics at the Institut Teknologi Bandung and David Laser Scan software. For the conventional model, themesio-distal width, intercanine width, and intermolar width were measured using digital calipers; in the 3D digital study model they were measured using software. There were no significant differences between the mesio-distal width, intercanine width, and intermolar width measurments between the conventional and 3D digital study models (p>0.05). Thus, measurements using 3D digital study models are as accurate as those obtained from conventional study models

  4. The Real Cost of "Cosmetic Tourism" Cost Analysis Study of "Cosmetic Tourism" Complications Presenting to a Public Hospital.

    Science.gov (United States)

    Livingston, Ryan; Berlund, Paul; Eccles-Smith, Jade; Sawhney, Raja

    2015-01-01

    "Cosmetic Tourism," the process of traveling overseas for cosmetic procedures, is an expanding global phenomenon. The model of care by which these services are delivered can limit perioperative assessment and postoperative follow-up. Our aim was to establish the number and type of complications being treated by a secondary referral hospital resulting from "cosmetic tourism" and the cost that has been incurred by the hospital in a 1-year period. Retrospective cost analysis and chart review of patients admitted to the hospital between the financial year of 2012 and 2013 were performed. Twelve "cosmetic tourism" patients presented to the hospital, requiring admission during the study period. Breast augmentation was the most common procedure and infected prosthesis was the most common complication (n = 4). Complications ranged from infection, pulmonary embolism to penile necrosis. The average cost of treating these patients was $AUD 12 597.71. The overall financial burden of the complication to the hospital was AUD$151 172.52. The "cosmetic tourism" model of care appears to be, in some cases, suboptimal for patients and their regional hospitals. In the cases presented in this study, it appears that care falls on the patient local hospital and home country to deal with the complications from their surgery abroad. This incurs a financial cost to that hospital in addition to redirecting medical resources that would otherwise be utilized for treating noncosmetic complications, without any remuneration to the local provider.

  5. Self-presentation origins of choking: evidence from separate pressure manipulations.

    Science.gov (United States)

    Mesagno, Christopher; Harvey, Jack T; Janelle, Christopher M

    2011-06-01

    Whether self-presentation is involved in the choking process remains unknown. The purpose of the current study was to determine the role of self-presentation concerns on the frequency of choking within the context of a recently proposed self-presentation model. Experienced field hockey players (N = 45) were randomly assigned to one of five groups (i.e., performance-contingent monetary incentive, video camera placebo, video camera self-presentation, audience, or combined pressure), before taking penalty strokes in low- and high-pressure phases. Results indicated that groups exposed to self-presentation manipulations experienced choking, whereas those receiving motivational pressure treatments decreased anxiety and increased performance under pressure. Furthermore, cognitive state anxiety mediated the relationship between the self-presentation group and performance. These findings provide quantitative support for the proposed self-presentation model of choking, while also holding implications for anxiety manipulations in future sport psychology research.

  6. Implementation and validation of the condensation model for containment hydrogen distribution studies

    International Nuclear Information System (INIS)

    Ravva, Srinivasa Rao; Iyer, Kannan N.; Gupta, S.K.; Gaikwad, Avinash J.

    2014-01-01

    Highlights: • A condensation model based on diffusion was implemented in FLUENT. • Validation of a condensation model for the H 2 distribution studies was performed. • Multi-component diffusion is used in the present work. • Appropriate grid and turbulence model were identified. - Abstract: This paper aims at the implementation details of a condensation model in the CFD code FLUENT and its validation so that it can be used in performing the containment hydrogen distribution studies. In such studies, computational fluid dynamics simulations are necessary for obtaining accurate predictions. While steam condensation plays an important role, commercial CFD codes such as FLUENT do not have an in-built condensation model. Therefore, a condensation model was developed and implemented in the FLUENT code through user defined functions (UDFs) for the sink terms in the mass, momentum, energy and species balance equations together with associated turbulence quantities viz., kinetic energy and dissipation rate. The implemented model was validated against the ISP-47 test of TOSQAN facility using the standard wall functions and enhanced wall treatment approaches. The best suitable grid size and the turbulence model for the low density gas (He) distribution studies are brought out in this paper

  7. Kinetic modelling and characterization of microbial community present in a full-scale UASB reactor treating brewery effluent.

    Science.gov (United States)

    Enitan, Abimbola M; Kumari, Sheena; Swalaha, Feroz M; Adeyemo, J; Ramdhani, Nishani; Bux, Faizal

    2014-02-01

    The performance of a full-scale upflow anaerobic sludge blanket (UASB) reactor treating brewery wastewater was investigated by microbial analysis and kinetic modelling. The microbial community present in the granular sludge was detected using fluorescent in situ hybridization (FISH) and further confirmed using polymerase chain reaction. A group of 16S rRNA based fluorescent probes and primers targeting Archaea and Eubacteria were selected for microbial analysis. FISH results indicated the presence and dominance of a significant amount of Eubacteria and diverse group of methanogenic Archaea belonging to the order Methanococcales, Methanobacteriales, and Methanomicrobiales within in the UASB reactor. The influent brewery wastewater had a relatively high amount of volatile fatty acids chemical oxygen demand (COD), 2005 mg/l and the final COD concentration of the reactor was 457 mg/l. The biogas analysis showed 60-69% of methane, confirming the presence and activities of methanogens within the reactor. Biokinetics of the degradable organic substrate present in the brewery wastewater was further explored using Stover and Kincannon kinetic model, with the aim of predicting the final effluent quality. The maximum utilization rate constant U max and the saturation constant (K(B)) in the model were estimated as 18.51 and 13.64 g/l/day, respectively. The model showed an excellent fit between the predicted and the observed effluent COD concentrations. Applicability of this model to predict the effluent quality of the UASB reactor treating brewery wastewater was evident from the regression analysis (R(2) = 0.957) which could be used for optimizing the reactor performance.

  8. Status of molten fuel coolant interaction studies and theoretical modelling work at IGCAR

    International Nuclear Information System (INIS)

    Rao, P.B.; Singh, Om Pal; Singh, R.S.

    1994-01-01

    The status of Molten Fuel Coolant Interaction (MFCI) studies is reviewed and some of the important observations made are presented. A new model for MFCI that is developed at IGCAR by considering the various mechanisms in detail is described. The model is validated and compared with the available experimental data and theoretical work at different stages of its development. Several parametric studies that are carried using this model are described. The predictions from this model have been found to be satisfactory, considering the complexity of the MFCI. A need for more comprehensive and MFCI-specific experimental tests is brought out. (author)

  9. pyLIMA: An Open-source Package for Microlensing Modeling. I. Presentation of the Software and Analysis of Single-lens Models

    Science.gov (United States)

    Bachelet, E.; Norbury, M.; Bozza, V.; Street, R.

    2017-11-01

    Microlensing is a unique tool, capable of detecting the “cold” planets between ˜1 and 10 au from their host stars and even unbound “free-floating” planets. This regime has been poorly sampled to date owing to the limitations of alternative planet-finding methods, but a watershed in discoveries is anticipated in the near future thanks to the planned microlensing surveys of WFIRST-AFTA and Euclid's Extended Mission. Of the many challenges inherent in these missions, the modeling of microlensing events will be of primary importance, yet it is often time-consuming, complex, and perceived as a daunting barrier to participation in the field. The large scale of future survey data products will require thorough but efficient modeling software, but, unlike other areas of exoplanet research, microlensing currently lacks a publicly available, well-documented package to conduct this type of analysis. We present version 1.0 of the python Lightcurve Identification and Microlensing Analysis (pyLIMA). This software is written in Python and uses existing packages as much as possible to make it widely accessible. In this paper, we describe the overall architecture of the software and the core modules for modeling single-lens events. To verify the performance of this software, we use it to model both real data sets from events published in the literature and generated test data produced using pyLIMA's simulation module. The results demonstrate that pyLIMA is an efficient tool for microlensing modeling. We will expand pyLIMA to consider more complex phenomena in the following papers.

  10. Comparative study of void fraction models

    International Nuclear Information System (INIS)

    Borges, R.C.; Freitas, R.L.

    1985-01-01

    Some models for the calculation of void fraction in water in sub-cooled boiling and saturated vertical upward flow with forced convection have been selected and compared with experimental results in the pressure range of 1 to 150 bar. In order to know the void fraction axial distribution it is necessary to determine the net generation of vapour and the fluid temperature distribution in the slightly sub-cooled boiling region. It was verified that the net generation of vapour was well represented by the Saha-Zuber model. The selected models for the void fraction calculation present adequate results but with a tendency to super-estimate the experimental results, in particular the homogeneous models. The drift flux model is recommended, followed by the Armand and Smith models. (F.E.) [pt

  11. CONSTANTLY PRESENT: A THERAPY FOR JULIE

    Directory of Open Access Journals (Sweden)

    Valérie Perret

    2015-12-01

    Full Text Available In this case study, I present a client, Julie, using the model of "Self-in-Relationship" developed by Richard Erskine. I describe the domains open and closed to contact that I observed at the beginning of the therapy. Then I explain how I lead this client to awake the anesthetized poles by accompanying her with involved presence and full contact, while respecting her style of attachment, an avoiding attachment.

  12. Coastal circulation off Ratnagiri, west coast of India during monsoon seasons: a numerical model study.

    Digital Repository Service at National Institute of Oceanography (India)

    Samiksha, S.V.; Sharif, J.; Vethamony, P.

    Present study is the coastal circulation modelling off Ratnagiri under the influence of winds and tides. A two-dimensional hydrodynamic model MIKE 21HD has been used to simulate tides and currents, and model results are in a good agreement...

  13. Open Innovation and Business Model: A Brazilian Company Case Study

    Directory of Open Access Journals (Sweden)

    Elzo Alves Aranha

    2015-12-01

    Full Text Available Open Innovation is increasingly being introduced in international and national organizations for the creation of value. Open innovation is a practical tool, requiring new strategies and decisions from managers for the exploitation of innovative activities. The basic question that this study seeks to answer is linked to the practice of open innovation in connection with the open business model geared towards the creation of value in a Brazilian company. This paper aims to present a case study that illustrates how open innovation offers resources to change the open business model in order to create value for the Brazilian company. The case study method of a company in the sector of pharma-chemical products was used. The results indicate that internal sources of knowledge, external sources of knowledge and accentuate working partnerships were adopted by company as strategies to offer resources to change the open business model in order to create value.

  14. A systematic review and checklist presenting the main challenges for health economic modeling in personalized medicine: towards implementing patient-level models.

    Science.gov (United States)

    Degeling, Koen; Koffijberg, Hendrik; IJzerman, Maarten J

    2017-02-01

    The ongoing development of genomic medicine and the use of molecular and imaging markers in personalized medicine (PM) has arguably challenged the field of health economic modeling (HEM). This study aims to provide detailed insights into the current status of HEM in PM, in order to identify if and how modeling methods are used to address the challenges described in literature. Areas covered: A review was performed on studies that simulate health economic outcomes for personalized clinical pathways. Decision tree modeling and Markov modeling were the most observed methods. Not all identified challenges were frequently found, challenges regarding companion diagnostics, diagnostic performance, and evidence gaps were most often found. However, the extent to which challenges were addressed varied considerably between studies. Expert commentary: Challenges for HEM in PM are not yet routinely addressed which may indicate that either (1) their impact is less severe than expected, (2) they are hard to address and therefore not managed appropriately, or (3) HEM in PM is still in an early stage. As evidence on the impact of these challenges is still lacking, we believe that more concrete examples are needed to illustrate the identified challenges and to demonstrate methods to handle them.

  15. Patients' Experiences of Cancer Diagnosis as a Result of an Emergency Presentation: A Qualitative Study.

    Science.gov (United States)

    Black, Georgia; Sheringham, Jessica; Spencer-Hughes, Vicki; Ridge, Melanie; Lyons, Mairead; Williams, Charlotte; Fulop, Naomi; Pritchard-Jones, Kathy

    2015-01-01

    Cancers diagnosed following visits to emergency departments (ED) or emergency admissions (emergency presentations) are associated with poor survival and may result from preventable diagnostic delay. To improve outcomes for these patients, a better understanding is needed about how emergency presentations arise. This study sought to capture patients' experiences of this diagnostic pathway in the English NHS. Eligible patients were identified in a service evaluation of emergency presentations and invited to participate. Interviews, using an open-ended biographical structure, captured participants' experiences of healthcare services before diagnosis and were analysed thematically, informed by the Walter model of Pathways to Treatment and NICE guidance in an iterative process. Twenty-seven interviews were conducted. Three typologies were identified: A: Rapid investigation and diagnosis, and B: Repeated cycles of healthcare seeking and appraisal without resolution, with two variants where B1 appears consistent with guidance and B2 has evidence that management was not consistent with guidance. Most patients' (23/27) experiences fitted types B1 and B2. Potentially avoidable breakdowns in diagnostic pathways caused delays when patients were conflicted by escalating symptoms and a benign diagnosis given earlier by doctors. ED was sometimes used as a conduit to rapid testing by primary care clinicians, although this pathway was not always successful. This study draws on patients' experiences of their diagnosis to provide novel insights into how emergency presentations arise. Through these typologies, we show that the typical experience of patients diagnosed through an emergency presentation diverges significantly from normative pathways even when there is no evidence of serious service failures. Consultations were not a conduit to diagnosis when they inhibited patients' capacity to appraise their own symptoms appropriately and when they resulted in a reluctance to seek

  16. Studying the Aspects of Knowledge Creation in the LAB Studio Model

    Directory of Open Access Journals (Sweden)

    Kari-Pekka Heikkinen

    2016-06-01

    Full Text Available The organisations of higher education are constantly changing. Universities, colleges, private schools and online universities refine their pedagogical methods and learning models in a competitive market. This article is a study on whether one such model helps students to gain new knowledge. A study of the LAB studio model (LSM, which is a pedagogical model developing connections between working-life based problems and the recognition and development of business-related prototypes and start-up companies, is presented. The LSM, theoretically grounded in a constructivist view of learning with a project-based education at its core, has the key goal of educating entrepreneurial competences in higher education. Based on the case study, comprisinga literature review of knowledge creation and a survey, the qualitative results analysis suggests that LSM offers a promising support for knowledge creation. The results lead to the conclusion that LSM provides support especially for the various modes of the SECI model, such as socialisation and internalisation, and seems to support organisational knowledge creation aspects as well.

  17. Dynamical reduction models: present status and future developments

    Energy Technology Data Exchange (ETDEWEB)

    Bassi, Angelo [Dipartimento di Fisica Teorica, Universita degli Studi di Trieste, Strada Costiera 11, 34014 Trieste (Italy); Mathematisches Institut der Ludwig-Maximilians Universitaet, Theresienstr. 39, 80333 Munich (Germany)

    2007-05-15

    We review the major achievements of the dynamical reduction program, showing why and how it provides a unified, consistent description of physical phenomena, from the microscopic quantum domain to the macroscopic classical one. We discuss the difficulties in generalizing the existing models in order to comprise also relativistic quantum field theories. We point out possible future lines of research, ranging from mathematical physics to phenomenology.

  18. Geological evolution of the North Sea: Cross-border basin modeling study on the schillground high

    NARCIS (Netherlands)

    Heim, S.; Lutz, R.; Nelskamp, S.; Verweij, J.M.; Kaufmann, D.; Reinhardt, L.

    2013-01-01

    This study presents the results of a basin modeling study covering the cross-border area of the southern Schillground High in the Dutch-German offshore area. A high resolution petroleum system model has been constructed with the aim to evaluate the hydrocarbon generation potential of Carboniferous

  19. Implications of Model Structure and Detail for Utility Planning: Scenario Case Studies Using the Resource Planning Model

    Energy Technology Data Exchange (ETDEWEB)

    Mai, Trieu [National Renewable Energy Lab. (NREL), Golden, CO (United States); Barrows, Clayton [National Renewable Energy Lab. (NREL), Golden, CO (United States); Lopez, Anthony [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hale, Elaine [National Renewable Energy Lab. (NREL), Golden, CO (United States); Dyson, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Eurek, Kelly [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-04-01

    In this report, we analyze the impacts of model configuration and detail in capacity expansion models, computational tools used by utility planners looking to find the least cost option for planning the system and by researchers or policy makers attempting to understand the effects of various policy implementations. The present analysis focuses on the importance of model configurations — particularly those related to capacity credit, dispatch modeling, and transmission modeling — to the construction of scenario futures. Our analysis is primarily directed toward advanced tools used for utility planning and is focused on those impacts that are most relevant to decisions with respect to future renewable capacity deployment. To serve this purpose, we develop and employ the NREL Resource Planning Model to conduct a case study analysis that explores 12 separate capacity expansion scenarios of the Western Interconnection through 2030.

  20. Drift Scale Modeling: Study of Unsaturated Flow into a Drift Using a Stochastic Continuum Model

    International Nuclear Information System (INIS)

    Birkholzer, J.T.; Tsang, C.F.; Tsang, Y.W.; Wang, J.S

    1996-01-01

    Unsaturated flow in heterogeneous fractured porous rock was simulated using a stochastic continuum model (SCM). In this model, both the more conductive fractures and the less permeable matrix are generated within the framework of a single continuum stochastic approach, based on non-parametric indicator statistics. High-permeable fracture zones are distinguished from low-permeable matrix zones in that they have assigned a long range correlation structure in prescribed directions. The SCM was applied to study small-scale flow in the vicinity of an access tunnel, which is currently being drilled in the unsaturated fractured tuff formations at Yucca Mountain, Nevada. Extensive underground testing is underway in this tunnel to investigate the suitability of Yucca Mountain as an underground nuclear waste repository. Different flow scenarios were studied in the present paper, considering the flow conditions before and after the tunnel emplacement, and assuming steady-state net infiltration as well as episodic pulse infiltration. Although the capability of the stochastic continuum model has not yet been fully explored, it has been demonstrated that the SCM is a good alternative model feasible of describing heterogeneous flow processes in unsaturated fractured tuff at Yucca Mountain

  1. Experience in Modelling Nuclear Energy Systems with MESSAGE: Country Case Studies

    International Nuclear Information System (INIS)

    2018-01-01

    Member States have recognized the increasing need to model future nuclear power scenarios in order to develop strategies for sustainable nuclear energy systems. The IAEA model for energy supply strategy alternatives and their general environmental impacts (MESSAGE) code is a tool that supports energy analysis and planning in Member States. This publication documents the experience gained on modelling and scenario analysis of nuclear energy systems (NES) using the MESSAGE code through various case studies performed by the participating Member States on evaluation and planning for nuclear energy sustainability at the regional or national level. The publication also elaborates on experience gained in modelling of global nuclear energy systems with a focus on specific aspects of collaboration among technology holder and technology user countries and the introduction of innovative nuclear technologies. It presents country case studies covering a variety of nuclear energy systems based on a once-through fuel cycle and a closed fuel cycle for thermal reactors, fast reactors and advanced systems. The feedback from case studies proves the analytical capabilities of the MESSAGE model and highlight the path forward for further advancements in the MESSAGE code and NES modelling.

  2. [Face presentation: retrospective study of 32 cases at term].

    Science.gov (United States)

    Ducarme, G; Ceccaldi, P-F; Chesnoy, V; Robinet, G; Gabriel, R

    2006-05-01

    To determine the etiologic factors, circumstances of diagnosis, obstetrical management and complications of face presentation and to value the maternal and foetal prognosis of this presentation. Thirty-two cases of face presentation have been observed in the maternity wards of Reims and Troyes over the last 12 years. The incidence of face presentation was 0.7 per 1000 deliveries. Spontaneous vaginal delivery occurred with mento-anterior presentation 73% of the time and caesarean section was performed in 100% of mento-posterior presentation. There was no increasing rate of foetal or maternal mortality and morbidity with vaginal delivery. Face presentation is an unusual complication of pregnancy with obstetric factors that predispose the foetus to face presentation. The low foetal and maternal mortality and morbidity substantiate the effectiveness of conservative management in face presentation.

  3. Past, Present, and Future in the Scientific Study of Religion

    DEFF Research Database (Denmark)

    Mccorkle, William W.; Xygalatas, Dimitris

    2012-01-01

    The study of religion is by its nature and by its history multi-disciplinary, incorporating diverse research paradigms ranging from historiography to experimental approaches and from scientific positivism to postmodern reflection. At a conference on the Past, Present, and Future in the Scientific...... in the humani- ties. The Laboratory for the Experimental Research of Religion in Brno, who hosted this conference, is the product of these developments...

  4. Holes in the t-Jz model: A diagrammatic study

    International Nuclear Information System (INIS)

    Chernyshev, A.L.; Leung, P.W.

    1999-01-01

    The t-J z model is the strongly anisotropic limit of the t-J model which captures some general properties of doped antiferromagnets (AF close-quote s). The absence of spin fluctuations simplifies the analytical treatment of hole motion in an AF background, and allows us to calculate single- and two-hole spectra with a high accuracy using a regular diagram technique combined with a real-space approach. At the same time, numerical studies of this model via exact diagonalization on small clusters show negligible finite-size effects for a number of quantities, thus allowing a direct comparison between analytical and numerical results. Both approaches demonstrate that the holes have a tendency to pair in p- and d-wave channels at realistic values of t/J. Interactions leading to pairing and effects selecting p and d waves are thoroughly investigated. The role of transverse spin fluctuations is considered using perturbation theory. Based on the results of the present study, we discuss the pairing problem in the realistic t-J-like model. Possible implications for preformed pairs formation and phase separation are drawn. copyright 1999 The American Physical Society

  5. Fuzzy net present valuation based on risk assessment of Malaysian infrastructure

    Science.gov (United States)

    Shaffie, Siti Salihah; Jaaman, Saiful Hafizah; Mohamad, Daud

    2017-04-01

    In recent years, built-operate-transfer (BOT) projects have profoundly been accepted under project financing for infrastructure developments in many countries. It requires high financing and involves complex mutual risk. The assessment of the risks is vital to avert huge financial loss. Net present value is widely applied to BOT project where the uncertainties in cash flows are deemed to be deterministic values. This study proposed a fuzzy net present value model taking consideration the assessment of risks from the BOT project. The proposed model is adopted to provide more flexible net present valuation of the project. It is shown and proven that the improved fuzzy cash flow model will provide a valuation that is closed to the real value of the project.

  6. STRESS RESPONSE STUDIES USING ANIMAL MODELS

    Science.gov (United States)

    This presentation will provide the evidence that ozone exposure in animal models induce neuroendocrine stress response and this stress response modulates lung injury and inflammation through adrenergic and glucocorticoid receptors.

  7. Can a model of study activity increase didactic dialogue and students' understanding of learning in IPE?

    DEFF Research Database (Denmark)

    Hansen, Bodil Winther; Hatt, Camusa

    at Metropolitan University College. Since 2013 all UCS have worked with a nationally decided study activity model. The model outlines four different types of learning activities. Students are introduced to courses via the model to heighten their understanding of course design and the expectations...... combining quantitative surveys, interviews, observation and focus groups. Comparisonldiscussion: The presentation will discuss the ambition to optimize dialogue about learning between lecturers and students by using a model of study activity. Results related to the value and potential of the model as seen...... by both lecturers and students will be presented. Findings/results/outcomes/effects: Students point out that the model can be a useful tool to gain an overview of learning activities and the amount of time they are expected to spend in courses. When lecturers introduce courses via the model it deepens...

  8. Descriptive analysis of context evaluation instrument for technical oral presentation skills evaluation: A case study in English technical communication course

    Science.gov (United States)

    Mohamed, Abdullah-Adnan; Asmawi, Adelina; Hamid, Mohd Rashid Ab; Mustafa, Zainol bin

    2015-02-01

    This paper reports a pilot study of Context Evaluation using a self-developed questionnaire distributed among engineering undergraduates at a university under study. The study aims to validate the self-developed questionnaires used in the Context evaluation, a component in the CIPP Model. The Context evaluation assesses background information for needs, assets, problems and opportunities relevant to beneficiaries of the study in a defined environment. Through the questionnaire, background information for the assessment of needs, assets and problems related to the engineering undergraduates' perceptions on the teaching and learning of technical oral presentation skills was collected and analysed. The questionnaire was developed using 5-points Likert scale to measure the constructs under study. They were distributed to 100 respondents with 79 returned. The respondents consisted of engineering undergraduates studied at various faculties at one technical university in Malaysia. The descriptive analysis of data for each item which makes up the construct for Context evaluation is found to be high. This implied that engineering undergraduates showed high interest in teaching and learning of technical oral presentation skills, thus their needs are met. Also, they agreed that assets and facilities are conducive to their learning. In conclusion, the context evaluation involving needs and assets factors are both considerably important; their needs are met and the assets and facilities do support their technical oral presentation skills learning experience.

  9. Testing a Poisson Counter Model for Visual Identification of Briefly Presented, Mutually Confusable Single Stimuli in Pure Accuracy Tasks

    Science.gov (United States)

    Kyllingsbaek, Soren; Markussen, Bo; Bundesen, Claus

    2012-01-01

    The authors propose and test a simple model of the time course of visual identification of briefly presented, mutually confusable single stimuli in pure accuracy tasks. The model implies that during stimulus analysis, tentative categorizations that stimulus i belongs to category j are made at a constant Poisson rate, v(i, j). The analysis is…

  10. Summarized presentation of the numerical model used for the pressurizer of a light water nuclear reactor. Description and validation

    International Nuclear Information System (INIS)

    Siarry, P.

    1981-12-01

    The pressurizer model is first described together with its coupling to the nuclear unit. The different stages involved in the validation are then presented: validation of overall qualitative behavior; validation of the open loop pressurizer model; validation of the various units for controlling pressures and levels; simulation of two large transients (Bugey plant) [fr

  11. Studying the Behaviour of Model of Mirror Neuron System in Case of Autism

    OpenAIRE

    Anirban, Shikha; Hanif Ali, Mohammad

    2012-01-01

    Several experiment done by the researchers conducted that autism is caused by the dysfunctional mirror neuron system and the dysfunctions of mirror neuron system is proportional to the symptom severity of autism. In the present work those experiments were studied as well as studying a model of mirror neuron system called MNS2 developed by a research group. This research examined the behavior of the model in case of autism and compared the result with those studies conducting dysfunctions of m...

  12. Minimal Z' models: present bounds and early LHC reach

    International Nuclear Information System (INIS)

    Salvioni, Ennio; Zwirner, Fabio; Villadoro, Giovanni

    2009-01-01

    We consider 'minimal' Z' models, whose phenomenology is controlled by only three parameters beyond the Standard Model ones: the Z' mass and two effective coupling constants. They encompass many popular models motivated by grand unification, as well as many arising in other theoretical contexts. This parameterization takes also into account both mass and kinetic mixing effects, which we show to be sizable in some cases. After discussing the interplay between the bounds from electroweak precision tests and recent direct searches at the Tevatron, we extend our analysis to estimate the early LHC discovery potential. We consider a center-of-mass energy from 7 towards 10 TeV and an integrated luminosity from 50 to several hundred pb -1 , taking all existing bounds into account. We find that the LHC will start exploring virgin land in parameter space for M Z' around 700 GeV, with lower masses still excluded by the Tevatron and higher masses still excluded by electroweak precision tests. Increasing the energy up to 10 TeV, the LHC will start probing a wider range of Z' masses and couplings, although several hundred pb -1 will be needed to explore the regions of couplings favored by grand unification and to overcome the Tevatron bounds in the mass region around 250 GeV.

  13. Modeling and cellular studies

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    Testing the applicability of mathematical models with carefully designed experiments is a powerful tool in the investigations of the effects of ionizing radiation on cells. The modeling and cellular studies complement each other, for modeling provides guidance for designing critical experiments which must provide definitive results, while the experiments themselves provide new input to the model. Based on previous experimental results the model for the accumulation of damage in Chlamydomonas reinhardi has been extended to include various multiple two-event combinations. Split dose survival experiments have shown that models tested to date predict most but not all the observed behavior. Stationary-phase mammalian cells, required for tests of other aspects of the model, have been shown to be at different points in the cell cycle depending on how they were forced to stop proliferating. These cultures also demonstrate different capacities for repair of sublethal radiation damage

  14. Progress report on SYVAC chemical speciation modelling studies during 1983/4

    International Nuclear Information System (INIS)

    Cross, J.; Smith, G.L.; Williams, D.R.

    1984-01-01

    This report summarises progress made on the SYVAC (System Variability Analysis program) chemical speciation project during 1983-4. Chemical speciation is defined and its importance in the SYVAC approach to Radioactive Waste Management is discussed. Computer modelling of chemical equilibria is described and the two programs presently operational at UWIST - SOLMNQ and MINEQL - are compared and discussed in detail. In view of the shortcomings of the databases supplied with these programs, a new database of equilibrium constants has been compiled containing 483 aqueous species and 329 solid phases, including data for the radionuclides uranium, plutonium, americium, neptunium and thorium. The collaborative work with AERE, Harwell, is reported. A leaching experiment carried out at Harwell has been modelled using the chemical speciation programs. The results for uranium, plutonium, americium and neptunium, are presented. However, the experimental data provided by AERE is insufficient for accurate simulations. Chemical speciation studies relating to specific sites require accurate characterisation of the groundwater, i.e. chemical composition, Eh and pH. In the absence of such information, preliminary studies have been made using an average granite groundwater. The results of these studies are presented and include solubility and speciation plots for uranium, plutonium, thorium and neptunium. The future aims of the project are discussed. (author)

  15. Molecular level in silico studies for oncology. Direct models review

    Science.gov (United States)

    Psakhie, S. G.; Tsukanov, A. A.

    2017-09-01

    The combination of therapy and diagnostics in one process "theranostics" is a trend in a modern medicine, especially in oncology. Such an approach requires development and usage of multifunctional hybrid nanoparticles with a hierarchical structure. Numerical methods and mathematical models play a significant role in the design of the hierarchical nanoparticles and allow looking inside the nanoscale mechanisms of agent-cell interactions. The current position of in silico approach in biomedicine and oncology is discussed. The review of the molecular level in silico studies in oncology, which are using the direct models, is presented.

  16. Long-term prognosis of patients presenting first-ever vestibular symptoms in a community-based study.

    Science.gov (United States)

    Felgueiras, Rui; Magalhães, Rui; Correia, Manuel; Silva, Maria Carolina

    2014-09-01

    Vestibular symptoms (VSs) are frequent complaints in patients attending ambulatory care and the emergency room. They may represent a peripheral vestibular disorder or a stroke/transient ischemic attack (TIA), yet many patients have VSs that cannot be clearly classified at presentation. This study aims to characterize and determine the long-term prognosis of these patients. In a prospective community-based study involving 104,700 individuals registered at 4 health centers of Northern Portugal, patients with a first-ever-in-lifetime focal neurologic symptom (FNS) were ascertained using comprehensive methods, including referrals from physicians working in the study area and data retrieved from emergency/discharge records. Physicians were encouraged to report/notify any patient who might have experienced an FNS, including those with vertigo or vertigo-like symptoms, imbalance, presyncope, or nonspecific dizziness. After neurologic assessment patients were classified as having a peripheral vestibular symptom (pVS), a stroke/TIA, or an unclassified vestibular symptom (uVS). They were followed up 7 years after the index event at the outpatient clinic; predictors of survival free from stroke or vascular events were determined using Cox proportional hazards models. Of the 1163 patients with an FNS, 360 (31.0%) were included, 16.7% had a stroke/TIA, 57.8% had pVS, and 25.6% had uVS. Most patients presented only isolated VSs (62.8%); 63% were women and mean age was 60.1 years (standard deviation = 16); hypertension (47.8%), hypercholesterolemia (41.9%), and diabetes (19.2%) were the most prevalent vascular risk factors (VRFs). Cranial computed tomography (CT) scan was performed in 63.3%. Adjusting for age, sex, VRFs, and diagnosis (TIA, pVS and uVS), the long-term risk of stroke was higher when CT showed silent infarctions (hazard rate [HR] = 3.96; 95% confidence interval [CI], 1.63-9.60) and the risk of vascular events (stroke, myocardial infarction, or vascular death) was

  17. [Environment and health in Gela (Sicily): present knowledge and prospects for future studies].

    Science.gov (United States)

    Musmeci, Loredana; Bianchi, Fabrizio; Carere, Mario; Cori, Liliana

    2009-01-01

    40-km range. Infact, the overall mortality rate for tumor and non-tumor causes in Gela is significantly higher for both sexes, and this is shown also in the Municipality of Niscemi, especially among the male population. Hospital discharge records for tumor causes, but especially for non-tumor ones, exceeded expectations in both genders and must be analysed taking into consideration the attraction exerted on the surrounding areas by the Gela hospital. Data analysis according to 5 ten-year birth cohorts, from 1915 to 1964, shows a decreasing mortality trend, whereas the increase of hospital admissions is confirmed in the younger generations. The issue of birth defects is recurrent in this area: a suitable register is lacking so that updated figures cannot be presented. However, data previously published showed excesses of prevalence rates of several specific birth defects, mainly urinary tract and genital anomalies. The same is worth in the incidence of new cancer cases since the development of a proper register is yet in progress. Tools and methodologies that should be applied in Gela to study environment-health relations are proposed, like Life Cycle Analysis, dispersion patterns and an air-quality monitoring system. A conceptual model considering all pollution sources and different exposure patterns present in Gela, developed by the Multidisciplinary Working Group, is presented. Among the activities carried out by regional authorities, two Reports on the Regional Environment Protection Agency monitoring activity and on the EU Program SEARCH, School Environment And Respiratory Health in Children, are included. A section is devoted to understanding what is necessary to build an epidemiological monitoring system specifically designed for this area, in order to keep under permanent control environment-related health outcomes. This includes a systematic and continuative collection, storage and analysis of environmental-induced diseases, exposure and risk factors, as well

  18. Modelling studies of horizontal steam generator PGV-1000 with Cathare

    Energy Technology Data Exchange (ETDEWEB)

    Karppinen, I. [VTT Energy, Espoo (Finland)

    1995-12-31

    To perform thermal-hydraulic studies applied to nuclear power plants equipped with VVER, a program of qualification and assessment of the CATHARE computer code is in progress at the Institute of Protection and Nuclear Safety (IPSN). In this paper studies of modelling horizontal steam generator of VVER-1000 with the CATHARE computer code are presented. Steady state results are compared with measured data from the fifth unit of Novovoronezh nuclear power plant. (orig.). 10 refs.

  19. Modelling studies of horizontal steam generator PGV-1000 with Cathare

    Energy Technology Data Exchange (ETDEWEB)

    Karppinen, I [VTT Energy, Espoo (Finland)

    1996-12-31

    To perform thermal-hydraulic studies applied to nuclear power plants equipped with VVER, a program of qualification and assessment of the CATHARE computer code is in progress at the Institute of Protection and Nuclear Safety (IPSN). In this paper studies of modelling horizontal steam generator of VVER-1000 with the CATHARE computer code are presented. Steady state results are compared with measured data from the fifth unit of Novovoronezh nuclear power plant. (orig.). 10 refs.

  20. Power excursion models applied to the study of secundary excursion in sodium cooled fast breeder reactors

    International Nuclear Information System (INIS)

    Messainguiral, Christiane.

    1980-06-01

    An evaluation of the energy that a secondary power excursion could release has been sought throughout the present work. A parametric study was therefore made by means of a power excursion code in fast reactors. The work submitted is therefore made up of the three following parts: Part 1. - (a), the secondary excursion is situated in the generally envisaged programmes and (b) the role of the principal parameters is studied in the calculation effected by the nuclear excursion code that was available at the start of the study. Part 2. - the results obtained for the power excursion calculations made are presented, Part 3. - the insufficient modelling of the reactivity present during the secondary power excursion is deduced from the parametric study just made. A definition is made of the characteristics of a model adapted to the calculation of this hypothetical accident and a new model as worked out within the scope of this work is submitted [fr

  1. Improved workflow modelling using role activity diagram-based modelling with application to a radiology service case study.

    Science.gov (United States)

    Shukla, Nagesh; Keast, John E; Ceglarek, Darek

    2014-10-01

    The modelling of complex workflows is an important problem-solving technique within healthcare settings. However, currently most of the workflow models use a simplified flow chart of patient flow obtained using on-site observations, group-based debates and brainstorming sessions, together with historic patient data. This paper presents a systematic and semi-automatic methodology for knowledge acquisition with detailed process representation using sequential interviews of people in the key roles involved in the service delivery process. The proposed methodology allows the modelling of roles, interactions, actions, and decisions involved in the service delivery process. This approach is based on protocol generation and analysis techniques such as: (i) initial protocol generation based on qualitative interviews of radiology staff, (ii) extraction of key features of the service delivery process, (iii) discovering the relationships among the key features extracted, and, (iv) a graphical representation of the final structured model of the service delivery process. The methodology is demonstrated through a case study of a magnetic resonance (MR) scanning service-delivery process in the radiology department of a large hospital. A set of guidelines is also presented in this paper to visually analyze the resulting process model for identifying process vulnerabilities. A comparative analysis of different workflow models is also conducted. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  2. Recommendations on presenting LHC searches for missing transverse energy signals using simplified s-channel models of dark matter

    DEFF Research Database (Denmark)

    Boveia, Antonio; Buchmueller, Oliver; Busoni, Giorgio

    2016-01-01

    This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on $s$-channel simplified dark matter models and to compare them to direct (indirect) detection experiments....

  3. Recommendations on presenting LHC searches for missing transverse energy signals using simplified s-channel models of dark matter

    International Nuclear Information System (INIS)

    Boveia, Antonio; Buchmueller, Oliver; Busoni, Giorgio; D' Eramo, Francesco; De Roeck, Albert; De Simone, Andrea; Doglioni, Caterina; Dolan, Matthew J.; Genest, Marie-Helene; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Heisig, Jan; Ippolito, Valerio; Kahlhoefer, Felix; Khoze, Velentin V.; Kulkarni, Sichota; Landsberg, Greg; Lowette, Steven; Malik, Sarah; Mangano, Michelangelo; McCabe, Christopher; Mrenna, Stephen; Pani, Priscilla; Du Pree, Tristan; Riotto, Antonio; Salek, David; Schmidt-Hoberg, Kai; Shepherd, William; Tait, Tim M.P.; Wang, Lian-Tao; Worm, Steven; Zurek, Kathryn

    2016-01-01

    This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on s-channel simplified dark matter models and to compare them to direct (indirect) detection experiments.

  4. Recommendations on presenting LHC searches for missing transverse energy signals using simplified s-channel models of dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Boveia, Antonio [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Antwerp Univ., Wilrijk (Belgium); Buchmueller, Oliver [Imperial College, London (United Kingdom); Busoni, Giorgio [Univ. of Melbourne (Australia); D' Eramo, Francesco [Univ. of California, Santa Cruz, CA (United States); De Roeck, Albert [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Antwerp Univ., Wilrijk (Belgium); De Simone, Andrea [Istituto Nazionale di Fisica Nucleare (INFN), Trieste (Italy); Doglioni, Caterina [Lund Univ. (Sweden); Dolan, Matthew J. [Univ. of Melbourne (Australia); Genest, Marie-Helene [Univ. of Grenoble, Saint-Martin-d' Hares (France); Hahn, Kristian [Northwestern Univ., Evanston, IL (United States); Haisch, Ulrich [Univ. of Oxford (United Kingdom); European Organization for Nuclear Research (CERN), Geneva (Switzerland); Harris, Philip C. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Heisig, Jan [RWTH Aachen Univ. (Germany); Ippolito, Valerio [Harvard Univ., Cambridge, MA (United States); Kahlhoefer, Felix [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Khoze, Velentin V. [Durham Univ. (United Kingdom); Kulkarni, Sichota [Austrian Academy of Sciences, Wien (Austria); Landsberg, Greg [Brown Univ., Providence, RI (United States); Lowette, Steven [Vrije Univ., Amsterdam (Netherlands); Malik, Sarah [Imperial College, London (United Kingdom); Mangano, Michelangelo [European Organization for Nuclear Research (CERN), Geneva (Switzerland); McCabe, Christopher [Univ. of Amsterdam (Netherlands); Mrenna, Stephen [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Pani, Priscilla [Stockholm Univ. (Sweden); du Pree, Tristan [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Riotto, Antonio [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Salek, David [Univ. of Amsterdam (Netherlands); Nikhef, Amsterdam (Netherlands); Schmidt-Hoberg, Kai [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Shepherd, William [Univ. of Copenhagen (Denmark); Tait, Tim M.P. [Univ. of California, Irvine, CA (United States); Wang, Lian-Tao [Univ. of Chicago, IL (United States); Worm, Steven [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL); Zurek, Kathryn [Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-03-14

    This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on s-channel simplified dark matter models and to compare them to direct (indirect) detection experiments.

  5. Recommendations on presenting LHC searches for missing transverse energy signals using simplified $s$-channel models of dark matter

    CERN Document Server

    Boveia, Antonio; Busoni, Giorgio; D'Eramo, Francesco; De Roeck, Albert; De Simone, Andrea; Doglioni, Caterina; Dolan, Matthew J.; Genest, Marie-Helene; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Heisig, Jan; Ippolito, Valerio; Kahlhoefer, Felix; Khoze, Valentin V.; Kulkarni, Suchita; Landsberg, Greg; Lowette, Steven; Malik, Sarah; Mangano, Michelangelo; McCabe, Christopher; Mrenna, Stephen; Pani, Priscilla; Pree, Tristan du; Riotto, Antonio; Salek, David; Schmidt-Hoberg, Kai; Shepherd, William; Tait, Tim M. P.; Wang, Lian-Tao; Worm, Steven; Zurek, Kathryn

    2016-01-01

    This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on $s$-channel simplified dark matter models and to compare them to direct (indirect) detection experiments.

  6. BIOMOVS: an international model validation study

    International Nuclear Information System (INIS)

    Haegg, C.; Johansson, G.

    1988-01-01

    BIOMOVS (BIOspheric MOdel Validation Study) is an international study where models used for describing the distribution of radioactive and nonradioactive trace substances in terrestrial and aquatic environments are compared and tested. The main objectives of the study are to compare and test the accuracy of predictions between such models, explain differences in these predictions, recommend priorities for future research concerning the improvement of the accuracy of model predictions and act as a forum for the exchange of ideas, experience and information. (author)

  7. BIOMOVS: An international model validation study

    International Nuclear Information System (INIS)

    Haegg, C.; Johansson, G.

    1987-01-01

    BIOMOVS (BIOspheric MOdel Validation Study) is an international study where models used for describing the distribution of radioactive and nonradioactive trace substances in terrestrial and aquatic environments are compared and tested. The main objectives of the study are to compare and test the accuracy of predictions between such models, explain differences in these predictions, recommend priorities for future research concerning the improvement of the accuracy of model predictions and act as a forum for the exchange of ideas, experience and information. (orig.)

  8. 3-dimensional orthodontics visualization system with dental study models and orthopantomograms

    Science.gov (United States)

    Zhang, Hua; Ong, S. H.; Foong, K. W. C.; Dhar, T.

    2005-04-01

    The aim of this study is to develop a system that provides 3-dimensional visualization of orthodontic treatments. Dental plaster models and corresponding orthopantomogram (dental panoramic tomogram) are first digitized and fed into the system. A semi-auto segmentation technique is applied to the plaster models to detect the dental arches, tooth interstices and gum margins, which are used to extract individual crown models. 3-dimensional representation of roots, generated by deforming generic tooth models with orthopantomogram using radial basis functions, is attached to corresponding crowns to enable visualization of complete teeth. An optional algorithm to close the gaps between deformed roots and actual crowns by using multi-quadratic radial basis functions is also presented, which is capable of generating smooth mesh representation of complete 3-dimensional teeth. User interface is carefully designed to achieve a flexible system with as much user friendliness as possible. Manual calibration and correction is possible throughout the data processing steps to compensate occasional misbehaviors of automatic procedures. By allowing the users to move and re-arrange individual teeth (with their roots) on a full dentition, this orthodontic visualization system provides an easy and accurate way of simulation and planning of orthodontic treatment. Its capability of presenting 3-dimensional root information with only study models and orthopantomogram is especially useful for patients who do not undergo CT scanning, which is not a routine procedure in most orthodontic cases.

  9. MCD Process Model: A Systematic Approach to Curriculum Development in Black Studies.

    Science.gov (United States)

    Miller, Howard J.

    1986-01-01

    Holds that Black Studies programs have had problems surviving because of (1) resistance to curriculum change in colleges and universities, (2) their lack of supporters in positions of administrative power, and (3) lack of an organized, conceptual approach to developing and implementing a Black Studies curriculum. Presents a model designed to…

  10. Breast cancer patients' presentation for oncological treatment: a single centre study.

    Science.gov (United States)

    Akinkuolie, Akinbolaji Andrew; Etonyeaku, Amarachukwu Chiduziem; Olasehinde, Olalekan; Arowolo, Olukayode Adeolu; Babalola, Rereloluwa Nicodemus

    2016-01-01

    Breast cancer patients are presenting at advanced stages for oncological treatment in Nigeria and World Health Organization predicted developing countries' breast cancer incidence and mortality to increase by year 2020. Prospective observational hospital based study that enrolled breast cancer patients from catchment area of an oncology service hospital in Nigeria between 2007 and 2013. Patients' demographics, breast cancer burden and health care giver presentation variables were analysed for causal factors of seeking medical help and what determines commencement of effective oncological treatment. Forty-six patients were enrolled, 19.6% of them presented primarily to oncologist while 80.4% presented secondarily for oncological treatment. There is a significant difference in presentation time for oncological treatment (t = -3.56, df = 42.90, p = 0.001) between primary (M =11.56 ± 5.21 weeks) and secondary presentation (M= 52.56 ± 10.27weeks). Tumor burden of those that presented secondarily were significantly more advanced (U = 78.5, p = 0.011) and, univariate analysis reveals that: patients' matrimonial setting, breast cancer awareness and mode of discovery of breast symptoms are patient related factors that determines their choice of health care providers and, determinant of effective oncological treatment is patient first contact health care provider. Patients' bio-characteristics that determine their choice of health care provider should be incorporated into community breast cancer sensitization drives. Additionally, there is a need for a government agency assign the task of accrediting and defining scope of enterprise of health care institutions and their health care providers in our pluralist health system.

  11. Breast cancer patients’ presentation for oncological treatment: a single centre study

    Science.gov (United States)

    Akinkuolie, Akinbolaji Andrew; Etonyeaku, Amarachukwu Chiduziem; Olasehinde, Olalekan; Arowolo, Olukayode Adeolu; Babalola, Rereloluwa Nicodemus

    2016-01-01

    Introduction Breast cancer patients are presenting at advanced stages for oncological treatment in Nigeria and World Health Organization predicted developing countries’ breast cancer incidence and mortality to increase by year 2020. Methods Prospective observational hospital based study that enrolled breast cancer patients from catchment area of an oncology service hospital in Nigeria between 2007 and 2013. Patients’ demographics, breast cancer burden and health care giver presentation variables were analysed for causal factors of seeking medical help and what determines commencement of effective oncological treatment. Results Forty-six patients were enrolled, 19.6% of them presented primarily to oncologist while 80.4% presented secondarily for oncological treatment. There is a significant difference in presentation time for oncological treatment (t = -3.56, df = 42.90, p = 0.001) between primary (M =11.56 ± 5.21 weeks) and secondary presentation (M= 52.56 ± 10.27weeks). Tumor burden of those that presented secondarily were significantly more advanced (U = 78.5, p = 0.011) and, univariate analysis reveals that: patients’ matrimonial setting, breast cancer awareness and mode of discovery of breast symptoms are patient related factors that determines their choice of health care providers and, determinant of effective oncological treatment is patient first contact health care provider. Conclusion Patients’ bio-characteristics that determine their choice of health care provider should be incorporated into community breast cancer sensitization drives. Additionally, there is a need for a government agency assign the task of accrediting and defining scope of enterprise of health care institutions and their health care providers in our pluralist health system. PMID:27642404

  12. Assessing Timely Presentation to Care Among People Diagnosed with HIV During Hospital Admission: A Population-Based Study in Ontario, Canada.

    Science.gov (United States)

    Kendall, Claire E; Shoemaker, Esther S; Raboud, Janet; Mark, Amy E; Bayoumi, Ahmed M; Burchell, Ann N; Loutfy, Mona; Rourke, Sean B; Liddy, Clare E; Rosenes, Ron; Rogers, Timothy; Antoniou, Tony

    2018-03-13

    Timely presentation to care for people newly diagnosed with HIV is critical to optimize health outcomes and reduce onward HIV transmission. Studies describing presentation to care following diagnosis during a hospital admission are lacking. We sought to assess the timeliness of presentation to care and to identify factors associated with delayed presentation. We conducted a population-level study using health administrative databases. Participants were all individuals older than 16 and newly diagnosed with HIV during hospital admission in Ontario, Canada, between April 1, 2007 and March 31, 2015. We used modified Poisson regression models to derive relative risk ratios for the association between sociodemographic and clinical variables and the presentation to out-patient HIV care by 90 days following hospital discharge. Among 372 patients who received a primary HIV diagnosis in hospital, 83.6% presented to care by 90 days. Following multivariable analysis, we did not find associations between patient sociodemographic or clinical characteristics and presentation to care by 90 days. In a secondary analysis of 483 patients diagnosed during hospitalization but for whom HIV was not recorded as the principal reason for admission, 73.1% presented to care by 90 days. Following multivariable adjustment, we found immigrants from countries with generalized HIV epidemics (RR 1.265, 95% CI 1.133-1.413) were more likely to present to care, whereas timely presentation was less likely for people with a mental health diagnosis (RR 0.817, 95% CI 0.742-0.898) and women (RR 0.748, 95% CI 0.559-1.001). Future work should evaluate mechanisms to facilitate presentation to care among these populations.

  13. A study of pilot modeling in multi-controller tasks

    Science.gov (United States)

    Whitbeck, R. F.; Knight, J. R.

    1972-01-01

    A modeling approach, which utilizes a matrix of transfer functions to describe the human pilot in multiple input, multiple output control situations, is studied. The approach used was to extend a well established scalar Wiener-Hopf minimization technique to the matrix case and then study, via a series of experiments, the data requirements when only finite record lengths are available. One of these experiments was a two-controller roll tracking experiment designed to force the pilot to use rudder in order to coordinate and reduce the effects of aileron yaw. One model was computed for the case where the signals used to generate the spectral matrix are error and bank angle while another model was computed for the case where error and yaw angle are the inputs. Several anomalies were observed to be present in the experimental data. These are defined by the descriptive terms roll up, break up, and roll down. Due to these algorithm induced anomalies, the frequency band over which reliable estimates of power spectra can be achieved is considerably less than predicted by the sampling theorem.

  14. Evaluation of Seasonal, ANN, and Hybrid Models in Modeling Urban Water Consumption A Case Study of Rash City

    Directory of Open Access Journals (Sweden)

    Seyed Nematollah Mousavi

    2016-09-01

    Full Text Available Forecasting future water consumption in cities to plan for the required capacities in urban water supply systems (including water transmission networks and water treatment facilities depends on the application of behavioral models of uban water consumption. Being located in the North-South corridor, Rasht City is assuming a new role to play in the national economy as a foreign trade center. It will, thus, be necessary to review its present urban infrastructure in order to draft the required infrastructural development plans for meeting the city’s future water demands. The three Seasonal Autoregressive Integrated Moving Average (SARIMA, Artificial Neural Network (ANN, and SARIMABP approaches were employed in present study to model and forecast Rasht urban water consumption using monthly time series for the period 2001‒2008 of urban water consumption in Rasht. The seasonal unit root test was applied to develop the relevant SARIMA model. Results showed that all the seasonal and non-seasonal unit roots are present in all the frequencies in the monthly time series for Rasht urban water consumption. Using a proper filter, the SAIMA patterns were estimated. In a second stage the SARIMA output was used to determine the ANN output and the hybrid SARIMABP structure was accordingly constructed. The values for Rasht urban water consumption predicted by the three models indicated the superiority of the SARIMABP hybrid model as evidenced by the forecast error index of 0.41% obtained for this model. The other two models of SARIMA and ANN were, however, found to yield acceptable results for urban water managers since the forecasting error recorded for them was below 1%.

  15. Estimating net present value variability for deterministic models

    NARCIS (Netherlands)

    van Groenendaal, W.J.H.

    1995-01-01

    For decision makers the variability in the net present value (NPV) of an investment project is an indication of the project's risk. So-called risk analysis is one way to estimate this variability. However, risk analysis requires knowledge about the stochastic character of the inputs. For large,

  16. Towards artificial tissue models: past, present, and future of 3D bioprinting.

    Science.gov (United States)

    Arslan-Yildiz, Ahu; El Assal, Rami; Chen, Pu; Guven, Sinan; Inci, Fatih; Demirci, Utkan

    2016-03-01

    Regenerative medicine and tissue engineering have seen unprecedented growth in the past decade, driving the field of artificial tissue models towards a revolution in future medicine. Major progress has been achieved through the development of innovative biomanufacturing strategies to pattern and assemble cells and extracellular matrix (ECM) in three-dimensions (3D) to create functional tissue constructs. Bioprinting has emerged as a promising 3D biomanufacturing technology, enabling precise control over spatial and temporal distribution of cells and ECM. Bioprinting technology can be used to engineer artificial tissues and organs by producing scaffolds with controlled spatial heterogeneity of physical properties, cellular composition, and ECM organization. This innovative approach is increasingly utilized in biomedicine, and has potential to create artificial functional constructs for drug screening and toxicology research, as well as tissue and organ transplantation. Herein, we review the recent advances in bioprinting technologies and discuss current markets, approaches, and biomedical applications. We also present current challenges and provide future directions for bioprinting research.

  17. Shadowing effects of offshore wind farms - an idealised mesoscale model study

    DEFF Research Database (Denmark)

    Volker, Patrick; Badger, Jake; Hahmann, Andrea N.

    The study of wind farm (WF) interaction is expected to gain importance, since the offshore wind farm density will increase especially in the North Sea in the near future. We present preliminary results of wind farm interaction simulated by mesoscale models. We use the Explicit Wake Parametrisatio...

  18. PIO I-II tendencies case study. Part 1. Mathematical modeling

    Directory of Open Access Journals (Sweden)

    Adrian TOADER

    2010-03-01

    Full Text Available In the paper, a study is performed from the perspective of giving a method to reduce the conservatism of the well known PIO (Pilot-Induced Oscillation criteria in predicting the susceptibility of an aircraft to this very harmful phenomenon. There are three interacting components of a PIO – the pilot, the vehicle, and the trigger (in fact, the hazard. The study, conceived in two parts, aims to underline the importance of human pilot model involved in analysis. In this first part, it is shown, following classical sources, how the LQG theory of control and estimation is used to obtain a complex model of human pilot. The approach is based on the argument, experimentally proved, that the human behaves “optimally” in some sense, subject to his inherent psychophysical limitations. The validation of such model is accomplished based on the experimental model of a VTOL-type aircraft. Then, the procedure of inserting typical saturation nonlinearities in the open loop transfer function is presented. A second part of the paper will illustrate PIO tendencies evaluation by means of a grapho-analytic method.

  19. Roadmap for Lean implementation in Indian automotive component manufacturing industry: comparative study of UNIDO Model and ISM Model

    Science.gov (United States)

    Jadhav, J. R.; Mantha, S. S.; Rane, S. B.

    2015-06-01

    The demands for automobiles increased drastically in last two and half decades in India. Many global automobile manufacturers and Tier-1 suppliers have already set up research, development and manufacturing facilities in India. The Indian automotive component industry started implementing Lean practices to fulfill the demand of these customers. United Nations Industrial Development Organization (UNIDO) has taken proactive approach in association with Automotive Component Manufacturers Association of India (ACMA) and the Government of India to assist Indian SMEs in various clusters since 1999 to make them globally competitive. The primary objectives of this research are to study the UNIDO-ACMA Model as well as ISM Model of Lean implementation and validate the ISM Model by comparing with UNIDO-ACMA Model. It also aims at presenting a roadmap for Lean implementation in Indian automotive component industry. This paper is based on secondary data which include the research articles, web articles, doctoral thesis, survey reports and books on automotive industry in the field of Lean, JIT and ISM. ISM Model for Lean practice bundles was developed by authors in consultation with Lean practitioners. The UNIDO-ACMA Model has six stages whereas ISM Model has eight phases for Lean implementation. The ISM-based Lean implementation model is validated through high degree of similarity with UNIDO-ACMA Model. The major contribution of this paper is the proposed ISM Model for sustainable Lean implementation. The ISM-based Lean implementation framework presents greater insight of implementation process at more microlevel as compared to UNIDO-ACMA Model.

  20. Potential and limitations of multidecadal satellite soil moisture observations for selected climate model evaluation studies

    Directory of Open Access Journals (Sweden)

    A. Loew

    2013-09-01

    Full Text Available Soil moisture is an essential climate variable (ECV of major importance for land–atmosphere interactions and global hydrology. An appropriate representation of soil moisture dynamics in global climate models is therefore important. Recently, a first multidecadal, observation-based soil moisture dataset has become available that provides information on soil moisture dynamics from satellite observations (ECVSM, essential climate variable soil moisture. The present study investigates the potential and limitations of this new dataset for several applications in climate model evaluation. We compare soil moisture data from satellite observations, reanalysis and simulations from a state-of-the-art land surface model and analyze relationships between soil moisture and precipitation anomalies in the different dataset. Other potential applications like model parameter optimization or model initialization are not investigated in the present study. In a detailed regional study, we show that ECVSM is capable to capture well the interannual and intraannual soil moisture and precipitation dynamics in the Sahelian region. Current deficits of the new dataset are critically discussed and summarized at the end of the paper to provide guidance for an appropriate usage of the ECVSM dataset for climate studies.

  1. Common marmoset (Callithrix jacchus) as a primate model for behavioral neuroscience studies.

    Science.gov (United States)

    Prins, Noeline W; Pohlmeyer, Eric A; Debnath, Shubham; Mylavarapu, Ramanamurthy; Geng, Shijia; Sanchez, Justin C; Rothen, Daniel; Prasad, Abhishek

    2017-06-01

    The common marmoset (Callithrix jacchus) has been proposed as a suitable bridge between rodents and larger primates. They have been used in several types of research including auditory, vocal, visual, pharmacological and genetics studies. However, marmosets have not been used as much for behavioral studies. Here we present data from training 12 adult marmosets for behavioral neuroscience studies. We discuss the husbandry, food preferences, handling, acclimation to laboratory environments and neurosurgical techniques. In this paper, we also present a custom built "scoop" and a monkey chair suitable for training of these animals. The animals were trained for three tasks: 4 target center-out reaching task, reaching tasks that involved controlling robot actions, and touch screen task. All animals learned the center-out reaching task within 1-2 weeks whereas learning reaching tasks controlling robot actions task took several months of behavioral training where the monkeys learned to associate robot actions with food rewards. We propose the marmoset as a novel model for behavioral neuroscience research as an alternate for larger primate models. This is due to the ease of handling, quick reproduction, available neuroanatomy, sensorimotor system similar to larger primates and humans, and a lissencephalic brain that can enable implantation of microelectrode arrays relatively easier at various cortical locations compared to larger primates. All animals were able to learn behavioral tasks well and we present the marmosets as an alternate model for simple behavioral neuroscience tasks. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Model quality and safety studies

    DEFF Research Database (Denmark)

    Petersen, K.E.

    1997-01-01

    The paper describes the EC initiative on model quality assessment and emphasizes some of the problems encountered in the selection of data from field tests used in the evaluation process. Further, it discusses the impact of model uncertainties in safety studies of industrial plants. The model...... that most of these have never been through a procedure of evaluation, but nonetheless are used to assist in making decisions that may directly affect the safety of the public and the environment. As a major funder of European research on major industrial hazards, DGXII is conscious of the importance......-tain model is appropriate for use in solving a given problem. Further, the findings from the REDIPHEM project related to dense gas dispersion will be highlighted. Finally, the paper will discuss the need for model quality assessment in safety studies....

  3. The Effect of Teacher Beliefs on Student Competence in Mathematical Modeling--An Intervention Study

    Science.gov (United States)

    Mischo, Christoph; Maaß, Katja

    2013-01-01

    This paper presents an intervention study whose aim was to promote teacher beliefs about mathematics and learning mathematics and student competences in mathematical modeling. In the intervention, teachers received written curriculum materials about mathematical modeling. The concept underlying the materials was based on constructivist ideas and…

  4. Experimental study of mass boiling in a porous medium model

    International Nuclear Information System (INIS)

    Sapin, Paul

    2014-01-01

    This manuscript presents a pore-scale experimental study of convective boiling heat transfer in a two-dimensional porous medium. The purpose is to deepen the understanding of thermohydraulics of porous media saturated with multiple fluid phases, in order to enhance management of severe accidents in nuclear reactors. Indeed, following a long-lasting failure in the cooling system of a pressurized water reactor (PWR) or a boiling water reactor (BWR) and despite the lowering of the control rods that stops the fission reaction, residual power due to radioactive decay keeps heating up the core. This induces water evaporation, which leads to the drying and degradation of the fuel rods. The resulting hot debris bed, comparable to a porous heat-generating medium, can be cooled down by reflooding, provided a water source is available. This process involves intense boiling mechanisms that must be modelled properly. The experimental study of boiling in porous media presented in this thesis focuses on the influence of different pore-scale boiling regimes on local heat transfer. The experimental setup is a model porous medium made of a bundle of heating cylinders randomly placed between two ceramic plates, one of which is transparent. Each cylinder is a resistance temperature detector (RTD) used to give temperature measurements as well as heat generation. Thermal measurements and high-speed image acquisition allow the effective heat exchanges to be characterized according to the observed local boiling regimes. This provides precious indications precious indications for the type of correlations used in the non-equilibrium macroscopic model used to model reflooding process. (author) [fr

  5. Modeling of the vapor cycle of Laguna Verde with the PEPSE code to conditions of thermal power licensed at present (2027 MWt)

    International Nuclear Information System (INIS)

    Castaneda G, M. A.; Maya G, F.; Medel C, J. E.; Cardenas J, J. B.; Cruz B, H. J.; Mercado V, J. J.

    2011-11-01

    By means of the use of the performance evaluation of power system efficiencies (PEPSE) code was modeled the vapor cycle of the nuclear power station of Laguna Verde to reproduce the nuclear plant behavior to conditions of thermal power, licensed at present (2027 MWt); with the purpose of having a base line before the implementation of the project of extended power increase. The model of the gauged vapor cycle to reproduce the nuclear plant conditions makes use of the PEPSE model, design case of the vapor cycle of nuclear power station of Laguna Verde, which has as main components of the model the great equipment of the vapor cycle of Laguna Verde. The design case model makes use of information about the design requirements of each equipment for theoretically calculating the electric power of exit, besides thermodynamic conditions of the vapor cycle in different points. Starting from the design model and making use of data of the vapor cycle measured in the nuclear plant; the adjustment factors were calculated for the different equipment s of the vapor cycle, to reproduce with the PEPSE model the real vapor cycle of Laguna Verde. Once characterized the model of the vapor cycle of Laguna Verde, we can realize different sensibility studies to determine the effects macros to the vapor cycle by the variation of certain key parameters. (Author)

  6. Functional renormalization group study of the Anderson–Holstein model

    International Nuclear Information System (INIS)

    Laakso, M A; Kennes, D M; Jakobs, S G; Meden, V

    2014-01-01

    We present a comprehensive study of the spectral and transport properties in the Anderson–Holstein model both in and out of equilibrium using the functional renormalization group (fRG). We show how the previously established machinery of Matsubara and Keldysh fRG can be extended to include the local phonon mode. Based on the analysis of spectral properties in equilibrium we identify different regimes depending on the strength of the electron–phonon interaction and the frequency of the phonon mode. We supplement these considerations with analytical results from the Kondo model. We also calculate the nonlinear differential conductance through the Anderson–Holstein quantum dot and find clear signatures of the presence of the phonon mode. (paper)

  7. Experimental and Computer Modelling Studies of Metastability of Amorphous Silicon Based Solar Cells

    NARCIS (Netherlands)

    Munyeme, Geoffrey

    2003-01-01

    We present a combination of experimental and computer modelling studies of the light induced degradation in the performance of amorphous silicon based single junction solar cells. Of particular interest in this study is the degradation kinetics of different types of amorphous silicon single junction

  8. Structural models of the different trimers present in the core of phycobilisomes from Gracilaria chilensis based on crystal structures and sequences.

    Directory of Open Access Journals (Sweden)

    Jorge Dagnino-Leone

    Full Text Available Phycobilisomes (PBS are accessory light harvesting protein complexes that directionally transfer energy towards photosystems. Phycobilisomes are organized in a central core and rods radiating from it. Components of phycobilisomes in Gracilaria chilensis (Gch are Phycobiliproteins (PBPs, Phycoerythrin (PE, and Phycocyanin (PC in the rods, while Allophycocyanin (APC is found in the core, and linker proteins (L. The function of such complexes depends on the structure of each component and their interaction. The core of PBS from cyanobacteria is mainly composed by cylinders of trimers of α and β subunits forming heterodimers of Allophycocyanin, and other components of the core including subunits αII and β18. As for the linkers, Linker core (LC and Linker core membrane (LCM are essential for the final emission towards photoreaction centers. Since we have previously focused our studies on the rods of the PBS, in the present article we investigated the components of the core in the phycobilisome from the eukaryotic algae, Gracilaria chilensis and their organization into trimers. Transmission electron microscopy provided the information for a three cylinders core, while the three dimensional structure of Allophycocyanin purified from Gch was determined by X-ray diffraction method and the biological unit was determined as a trimer by size exclusion chromatography. The protein sequences of all the components of the core were obtained by sequencing the corresponding genes and their expression confirmed by transcriptomic analysis. These subunits have seldom been reported in red algae, but not in Gracilaria chilensis. The subunits not present in the crystallographic structure were modeled to build the different composition of trimers. This article proposes structural models for the different types of trimers present in the core of phycobilisomes of Gch as a first step towards the final model for energy transfer in this system.

  9. Being present in action: a theoretical model about the interlocking between intentions and environmental affordances

    Directory of Open Access Journals (Sweden)

    Stefano eTriberti

    2016-01-01

    Full Text Available Recent neuropsychological evidence suggest that a key role in linking perceptions and intentions is played by sense of presence. Despite this phenomenon having been studied primarily in the field of virtual reality (conceived as the illusion of being in the virtual space, recent research highlighted that it is a fundamental feature of everyday experience. Specifically, the function of presence as a cognitive process is to locate the Self in a physical space or situation, based on the perceived possibility to act in it; so, the variations in sense of presence allow one to continuously adapt his own action to the external environment. Indeed intentions, as the cognitive antecedents of action, are not static representations of the desired outcomes, but dynamic processes able to adjust their own representational content according to the opportunities/restrictions emerging in the environment. Focusing on the peculiar context of action mediated by interactive technologies, we here propose a theoretical model showing how each level of an intentional hierarchy (future-directed; present directed; and motor intentions can interlock with environmental affordances in order to promote a continuous stream of action and activity.

  10. A model for fine mapping in family based association studies.

    Science.gov (United States)

    Boehringer, Stefan; Pfeiffer, Ruth M

    2009-01-01

    Genome wide association studies for complex diseases are typically followed by more focused characterization of the identified genetic region. We propose a latent class model to evaluate a candidate region with several measured markers using observations on families. The main goal is to estimate linkage disequilibrium (LD) between the observed markers and the putative true but unobserved disease locus in the region. Based on this model, we estimate the joint distribution of alleles at the observed markers and the unobserved true disease locus, and a penetrance parameter measuring the impact of the disease allele on disease risk. A family specific random effect allows for varying baseline disease prevalences for different families. We present a likelihood framework for our model and assess its properties in simulations. We apply the model to an Alzheimer data set and confirm previous findings in the ApoE region.

  11. Presenting Enterprise Architecture Strategies Using Business Model Canvas (Case Study of E-commerce PT Xyz)

    OpenAIRE

    Christini, Chintamy; Rahmad, Basuki

    2015-01-01

    Information Technology (IT) is known as enabler of business. One of the study that align business and IT is enterprise architecture. In this era, one of the business that become a trend the world is electronic commerce (e-commerce). With the suitable enterprise architecture strategies, e-commerce can be improved according to the business and IT condition. This paper represents about study case of an Indonesian e-commerce website which is still unknown by internet users and the SWOT strategy a...

  12. PRESENTATION OF AN ARCHITECTURAL OBJECT DESIGNED BY WARPED SURFACES

    Directory of Open Access Journals (Sweden)

    VELJKOVIĆ Milica

    2015-06-01

    Full Text Available Due to the importance of good functional solutions and aesthetic appearance of an object, modeling in architecture is the subject of this study. Application of more modern materials in architecture allows us to perform various geometric surfaces in the production of facade and roof structures. With such complex objects, it is necessary to create detailed three-dimensional models, using some of the modern software package for modeling. This paper provides an example of creating a 3D model of a modern building in whose exterior we can recognize nondevelopmental (becoming warped line-generated surfaces, primarily cylindroids and conoids. The entire process of modeling and presenting an object using augmented reality was carried out using the modern software package for visualization in architecture.

  13. Presentation

    Directory of Open Access Journals (Sweden)

    Eduardo Vicente

    2013-06-01

    effectivities more than a number of fixed essential characteristics. Luiz Artur Ferrareto (UFRGS, undertaking a theoretical proposal for categorizing radio content in four different levels of planning (segment, form, programming and content itself tries to “compare and contrast the practices of Brazilian commercial broadcasting companies to those used on the radio in the United States, a reference market for our national entrepreneurs”. Madalena Oliveira (University of Minho focuses on the current stage of communication researches in Portugal reflecting on the challenges for studying a culture based on listening in times of looking. Marko Ala-Fossi, (University of Tampere beginning with the statement that “radio evolution greatly depends not only on the cultural context of a country but also on the whole social, political, economic development of societies” gives us a projection on radio development around the world for the next decades. Closing the dossier, Rafael Duarte Oliveira Venancio (UFU assuming radio as language by definition and not as a device understands it as a section and an operating model in such language as it intersects the world. Another six articles, not enrolled in the dossier, round the edition off. Fernando de Tacca debates the category of “photocine” recurring to three recent Spanish productions. Gustavo Souza investigates the possibility of identifying a point of view in documentary movies while establishing a debate that joins the materialities of image and sound with the subjectivity resulting from interpretation. Vinicius Bandeira develops on the special duplicity present in the movies between what is and what is not subsumed by the camera. Neide Jallageas proposes the study of visual communication design from the first modelings, attempting especially to the radical propositions from the early XXth century avant-garde movement. Gilson Schwartz debates on the impact from the distribution of videogames as hegemonic cultural practice in

  14. Reviewing the effort-reward imbalance model: drawing up the balance of 45 empirical studies

    NARCIS (Netherlands)

    Vegchel, van N.; Jonge, de J.; Bosma, H.; Schaufeli, W.B.

    2005-01-01

    The present paper provides a review of 45 studies on the Effort–Reward Imbalance (ERI) Model published from 1986 to 2003 (inclusive). In 1986, the ERI Model was introduced by Siegrist et al. (Biological and Psychological Factors in Cardiovascular Disease, Springer, Berlin, 1986, pp. 104–126; Social

  15. APPLICATION OF AUGMENTED REALITY IN FACADE REDESIGN PRESENTATION

    Directory of Open Access Journals (Sweden)

    PEJIĆ Petar

    2015-06-01

    Full Text Available Augmented Reality (AR is a computer technology where the perception of the user is enhanced by the seamless blending between real environment and computer-generated virtual objects coexisting in the same space. When it comes to a redesign of the existing facades, it is necessary to create a visual presentation of the proposed changes. For this reason, contemporary architectural approach assumes creating a digital 3D model of the newly designed facade. Since the façade redesign is a real world change, the AR can be used for newly designed facade project presentation. In this paper a case study of the AR application for façade redesign presentation of a single family house located in Babušnica (Serbia is presented.

  16. Presenting Software Metrics Indicators- A Case Study

    DEFF Research Database (Denmark)

    Pantazos, Kostas; Shollo, Arisa; Staron, Miroslaw

    2010-01-01

    Industrial measurement systems in software projects can generate a large number of indicators (main measurements). Having a large number of indicators might result in failing to present an overview of the status of measured entities. In consequence, managers might experience problems when making...

  17. Model studies of the transfer of radionuclides in the Finnish environment

    International Nuclear Information System (INIS)

    Korhonen, R.

    1991-01-01

    Environmental modelling of the effects of radionuclide releases was studied. A computer model DETl2A was developed for evaluation of radionuclide transfer. The flexible structure of the model made it suitable for a wide range of applications. The model was employed to evaluate the biospheric transfer of radionuclides in two situations: 1) release cases from planned waste repositories in Finland, and 2) deposition due to the Chernobyl accident. The Chernobyl accident provided a good opportunity to test the DETRA model, originally constructed for waste disposal applications. A study was made of some biospheric local, regional and global scale scenarios, to which releases from repositories were assumed. Drinking water from a local well and consumption of fish were the most important dose pathways. The transfer of the Chernobyl deposition in some important Finnish transfer environments was evaluated. Especially the transfer of Cs-137 in the Kymijoki watercourse, including dynamic transfer to non-predatory and predatory fish species was studied. The calculated behaviour was compared with the measured behaviour. Nuclear weapon testing fallout was also considered in the comparison studies. On the basis of validation studies it was concluded that part of the Cs-137 deposition was in insoluble form. These model assumptions give that deposition consisting of soluble Cs-l37 could cause fourfold contamination of fish per unit deposition than deposition due to the Chernobyl accident in the modelled case. Model validation was also performed within international projects, in particular by participating in the BIOMOVS project. This participation will be continued in the VAMP program. In the summary part of the thesis the main attention is paid to modelling questions, whereas in the accompanying publications the results are presented in greater detail

  18. Contribution of the swine model in the study of human sexually transmitted infections

    DEFF Research Database (Denmark)

    Käser, Tobias; Renois, Fanny; Wilson, Heather L.

    2017-01-01

    The pig has garnered more and more interest as a model animal to study various conditions in humans. The growing success of the pig as an experimental animal model is explained by its similarities with humans in terms of anatomy, genetics, immunology, and physiology, by their manageable behavior...... transmitted diseases (STIs) like Chlamydia trachomatis. In the current review, we discuss the use of animal models for biomedical research on the major human STIs. We summarize results obtained in the most common animal models and focus on the contributions of the pig model towards the understanding...... of pathogenesis and the host immune response. In addition, we present the main features of the porcine model that are particularly relevant for the study of pathogens affecting human female and male genital tracts. We also inform on the technological advancements in the porcine toolbox to facilitate new...

  19. Modelling present-day basal melt rates for Antarctic ice shelves using a parametrization of buoyant meltwater plumes

    Science.gov (United States)

    Lazeroms, Werner M. J.; Jenkins, Adrian; Hilmar Gudmundsson, G.; van de Wal, Roderik S. W.

    2018-01-01

    Basal melting below ice shelves is a major factor in mass loss from the Antarctic Ice Sheet, which can contribute significantly to possible future sea-level rise. Therefore, it is important to have an adequate description of the basal melt rates for use in ice-dynamical models. Most current ice models use rather simple parametrizations based on the local balance of heat between ice and ocean. In this work, however, we use a recently derived parametrization of the melt rates based on a buoyant meltwater plume travelling upward beneath an ice shelf. This plume parametrization combines a non-linear ocean temperature sensitivity with an inherent geometry dependence, which is mainly described by the grounding-line depth and the local slope of the ice-shelf base. For the first time, this type of parametrization is evaluated on a two-dimensional grid covering the entire Antarctic continent. In order to apply the essentially one-dimensional parametrization to realistic ice-shelf geometries, we present an algorithm that determines effective values for the grounding-line depth and basal slope in any point beneath an ice shelf. Furthermore, since detailed knowledge of temperatures and circulation patterns in the ice-shelf cavities is sparse or absent, we construct an effective ocean temperature field from observational data with the purpose of matching (area-averaged) melt rates from the model with observed present-day melt rates. Our results qualitatively replicate large-scale observed features in basal melt rates around Antarctica, not only in terms of average values, but also in terms of the spatial pattern, with high melt rates typically occurring near the grounding line. The plume parametrization and the effective temperature field presented here are therefore promising tools for future simulations of the Antarctic Ice Sheet requiring a more realistic oceanic forcing.

  20. Adolescents' presentation of food in social media: An explorative study.

    Science.gov (United States)

    Holmberg, Christopher; E Chaplin, John; Hillman, Thomas; Berg, Christina

    2016-04-01

    The study aimed to explore how adolescents communicate food images in a widely used social media image-sharing application. We examined how and in what context food was presented and the type of food items that were frequently portrayed by following a youth related hashtag on Instagram. The hashtag #14år ("14 years") was used to find adolescent users on Instagram: these users public photo streams were then searched for food items they had shared with others. Food items were identified and categorized based on type of food and how the food items were presented. Most of the adolescent users (85%) shared images containing food items. A majority of the images (67.7%) depicted foods high in calories but low in nutrients. Almost half of these images were arranged as a still life with food brand names clearly exposed. Many of these images were influenced by major food marketing campaigns. Fruits and vegetables occurred in 21.8% of all images. This food group was frequently portrayed zoomed in with focus solely on the food, with a hashtag or caption expressing palatability. These images were often presented in the style of a cook book. Food was thus presented in varied ways. Adolescents themselves produced images copying food advertisements. This has clear health promotion implications since it becomes more challenging to monitor and tackle young people's exposure to marketing of unhealthy foods in these popular online networks because images are part of a lifestyle that the young people want to promote. Shared images contain personal recommendations, which mean that they may have a more powerful effect than commercial advertising. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Making online products more tangible : the effect of product presentation formats on product evaluations

    NARCIS (Netherlands)

    Verhagen, Tibert; Vonkeman, Charlotte; van Dolen, Willemijn

    2016-01-01

    Although several studies have looked at the effects of online product presentations on consumer decision making, no study thus far has considered a potential key factor in online product evaluations: tangibility. The present study aims at filling this gap by developing and testing a model that

  2. Study on visibility evaluation model which is considered field factors; Field factor wo koryoshita shininsei hyoka model ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Nakanishi, M; Hagiwara, T [Hokkaido University, Sapporo (Japan)

    1997-10-01

    The present study proposes a model to evaluate visual performance of road traffic facilities required for drivers. Two factors were employed to obtain the suitable contrast for drivers under driving situation. One factor is a suitable luminance range, which is derived from minimum required luminance and glare luminance. Another is a field. The model showed capability of providing visibility range in some cases. 8 refs., 4 figs., 2 tabs.

  3. A comparative study of turbulence models for dissolved air flotation flow analysis

    International Nuclear Information System (INIS)

    Park, Min A; Lee, Kyun Ho; Chung, Jae Dong; Seo, Seung Ho

    2015-01-01

    The dissolved air flotation (DAF) system is a water treatment process that removes contaminants by attaching micro bubbles to them, causing them to float to the water surface. In the present study, two-phase flow of air-water mixture is simulated to investigate changes in the internal flow analysis of DAF systems caused by using different turbulence models. Internal micro bubble distribution, velocity, and computation time are compared between several turbulence models for a given DAF geometry and condition. As a result, it is observed that the standard κ-ε model, which has been frequently used in previous research, predicts somewhat different behavior than other turbulence models

  4. Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies

    Directory of Open Access Journals (Sweden)

    Hans Mielke

    2012-01-01

    Full Text Available In this contribution we present three case studies of physiologically based toxicokinetic (PBTK modelling in regulatory risk assessment. (1 Age-dependent lower enzyme expression in the newborn leads to bisphenol A (BPA blood levels which are near the levels of the tolerated daily intake (TDI at the oral exposure as calculated by EFSA. (2 Dermal exposure of BPA by receipts, car park tickets, and so forth, contribute to the exposure towards BPA. However, at the present levels of dermal exposure there is no risk for the adult. (3 Dermal exposure towards coumarin via cosmetic products leads to external exposures of two-fold the TDI. PBTK modeling helped to identify liver peak concentration as the metric for liver toxicity. After dermal exposure of twice the TDI, the liver peak concentration was lower than that present after oral exposure with the TDI dose. In the presented cases, PBTK modeling was useful to reach scientifically sound regulatory decisions.

  5. Modelling and study of the optimal control of a pressurised nuclear reactor

    International Nuclear Information System (INIS)

    Hurault, Martine

    1974-01-01

    This research thesis reports the development of an analog simulation of a nuclear reactor. For this purpose, the number of equations had to be limited for technological reasons (size and capacity of the analog console). The author first presents the nuclear reactor equations, and the simulation equations, and reports the study of the simulation on an analog computer. Then, he presents a more restrained model which has been used to elaborate the command: kinetic and thermal equations, general equations, study on an analog computer. In the next part, the author presents the reactor steering system: algorithm, practical resolution, partial derivative method. He finally reports the selection of a realistic criterion and the development of a digital steering [fr

  6. Mercury Speciation in Coal-Fired Power Plant Flue Gas-Experimental Studies and Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Radisav Vidic; Joseph Flora; Eric Borguet

    2008-12-31

    The overall goal of the project was to obtain a fundamental understanding of the catalytic reactions that are promoted by solid surfaces present in coal combustion systems and develop a mathematical model that described key phenomena responsible for the fate of mercury in coal-combustion systems. This objective was achieved by carefully combining laboratory studies under realistic process conditions using simulated flue gas with mathematical modeling efforts. Laboratory-scale studies were performed to understand the fundamental aspects of chemical reactions between flue gas constituents and solid surfaces present in the fly ash and their impact on mercury speciation. Process models were developed to account for heterogeneous reactions because of the presence of fly ash as well as the deliberate addition of particles to promote Hg oxidation and adsorption. Quantum modeling was used to obtain estimates of the kinetics of heterogeneous reactions. Based on the initial findings of this study, additional work was performed to ascertain the potential of using inexpensive inorganic sorbents to control mercury emissions from coal-fired power plants without adverse impact on the salability fly ash, which is one of the major drawbacks of current control technologies based on activated carbon.

  7. Studies on Fragrance Delivery from Inorganic Nanocontainers: Encapsulation, Release and Modeling Studies

    Science.gov (United States)

    Ghodke, Shailesh Adinath; Sonawane, Shirish Hari; Bhanvase, Bharat Apparao; Mishra, Satyendra; Joshi, Kalpana Shrikant

    2015-04-01

    The present work deals with encapsulation of fragrance molecule in inorganic nanocontainers substrate and investigation of its prolonged release at different pH condition. The nanocontainers used were aluminosilicate clay (Halloysite) having cylindrical shape with outside diameter in the range of 30-50 nm, 15 nm lumen and length equal to 800 ± 300 nm. Rosewater absolute was used as a sample fragrance for loading in nanocontainer and delivery purpose. The fragrance loaded nanocontainers were coated with a thin layer of polyelectrolyte i.e. Polyacrylic Acid (PAA). The structural characteristics of prepared nanocontainers were determined by using Fourier Transform Intra-red Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA) and UV spectroscopy analysis. Release of fragrance molecules in the aqueous medium was monitored for 24 h. The fragrance release was found to be responsive as the amount of fragrance release increases with increase in pH value from 3 to 7. Fragrance release has been studied by using various permeation kinetic models such as zero order, first order, Hixson-Crowell, Higuchi, Korsmeyer-Peppas and Hopfenberg models. Korsemyer-Peppas shows the best fit (R2 = 0.9544) compared to other kinetic model for the release of fragrance from nanocontainers.

  8. Studying shocks in model astrophysical flows

    International Nuclear Information System (INIS)

    Chakrabarti, S.K.

    1989-01-01

    We briefly discuss some properties of the shocks in the existing models for quasi two-dimensional astrophysical flows. All of these models which allow the study of shock analytically have some unphysical characteristics due to inherent assumptions made. We propose a hybrid model for a thin flow which has fewer unpleasant features and is suitable for the study of shocks. (author). 5 refs

  9. Multimodal Languaging as a Pedagogical Model--A Case Study of the Concept of Division in School Mathematics

    Science.gov (United States)

    Joutsenlahti, Jorma; Kulju, Pirjo

    2017-01-01

    The purpose of this study is to present a multimodal languaging model for mathematics education. The model consists of mathematical symbolic language, a pictorial language, and a natural language. By applying this model, the objective was to study how 4th grade pupils (N = 21) understand the concept of division. The data was collected over six…

  10. Past and present of sediment and carbon biogeochemical cycling models

    Directory of Open Access Journals (Sweden)

    F. T. Mackenzie

    2004-01-01

    Full Text Available The global carbon cycle is part of the much more extensive sedimentary cycle that involves large masses of carbon in the Earth's inner and outer spheres. Studies of the carbon cycle generally followed a progression in knowledge of the natural biological, then chemical, and finally geological processes involved, culminating in a more or less integrated picture of the biogeochemical carbon cycle by the 1920s. However, knowledge of the ocean's carbon cycle behavior has only within the last few decades progressed to a stage where meaningful discussion of carbon processes on an annual to millennial time scale can take place. In geologically older and pre-industrial time, the ocean was generally a net source of CO2 emissions to the atmosphere owing to the mineralization of land-derived organic matter in addition to that produced in situ and to the process of CaCO3 precipitation. Due to rising atmospheric CO2 concentrations because of fossil fuel combustion and land use changes, the direction of the air-sea CO2 flux has reversed, leading to the ocean as a whole being a net sink of anthropogenic CO2. The present thickness of the surface ocean layer, where part of the anthropogenic CO2 emissions are stored, is estimated as of the order of a few hundred meters. The oceanic coastal zone net air-sea CO2 exchange flux has also probably changed during industrial time. Model projections indicate that in pre-industrial times, the coastal zone may have been net heterotrophic, releasing CO2 to the atmosphere from the imbalance between gross photosynthesis and total respiration. This, coupled with extensive CaCO3 precipitation in coastal zone environments, led to a net flux of CO2 out of the system. During industrial time the coastal zone ocean has tended to reverse its trophic status toward a non-steady state situation of net autotrophy, resulting in net uptake of anthropogenic CO2 and storage of carbon in the coastal ocean, despite the significant calcification

  11. Feasibility study of computerized presentation of procedures of a nuclear plant

    International Nuclear Information System (INIS)

    Takagawa, Kenichi; Niwa, Yuji; Urakami, Masahiro

    2010-01-01

    Introduction of a digital instrumentation control system is in progress in recent nuclear power plants, and an application of Computer Based Procedures (CBP) is being considered. The Institute of Nuclear Safety System, Incorporated has developed a system for a Computerized Presentation of Procedures (CPP) which corresponds to CBP. By fiscal year 2002, all items in the emergency operation procedures of a model plant were made displayable on the CPP. In 2003, the CPP instead of the paper based procedures was used for trial by the operators of a nuclear power plant in an actual training simulator, and feasibility of its practical application was evaluated. Based on the result, we considered subjects which should be taken into account in the future. As a result, improvements of CPP and its navigation system, etc. to enable operations with multi-procedures in parallel were extracted as primary subjects for introduction of CBP in the future as well as practical application of CPP. (author)

  12. STUDY OF CLINICAL PROFILE OF PATIENTS PRESENTING WITH SEXUAL PRECOCITY TO A TERTIARY CARE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Binoy Kumar Mohanty

    2016-07-01

    Full Text Available BACKGROUND Precocious puberty is a common paediatric endocrine disorder seen in clinical practice. OBJECTIVE To study the various aetiologies and clinical presentations of patients presenting with sexual precocity to a tertiary care hospital. DESIGN Cross sectional study. MATERIAL AND METHODS We collected and analysed the clinical data including hormonal status of 24 consecutive patients who presented to our department from January 2014 to December 2015 for evaluation of sexual precocity. RESULTS Most of the patients presenting to us had evidence of precocious puberty (n=16, followed by premature adrenarche (n=5 and premature thelarche (n=3 respectively. The females outnumbered males in our study (68.75% of total cases. Females presenting with central precocious puberty had no appreciable cause (idiopathic in majority (85.72% of cases. While, males presenting with central precocious puberty had an organic cause (60% in majority of cases. CONCLUSIONS Precocious puberty is more common among females as compared to males. Organic lesion must be ruled out in all patients presenting with central precocious puberty especially in males.

  13. Analytical study on model tests of soil-structure interaction

    International Nuclear Information System (INIS)

    Odajima, M.; Suzuki, S.; Akino, K.

    1987-01-01

    Since nuclear power plant (NPP) structures are stiff, heavy and partly-embedded, the behavior of those structures during an earthquake depends on the vibrational characteristics of not only the structure but also the soil. Accordingly, seismic response analyses considering the effects of soil-structure interaction (SSI) are extremely important for seismic design of NPP structures. Many studies have been conducted on analytical techniques concerning SSI and various analytical models and approaches have been proposed. Based on the studies, SSI analytical codes (computer programs) for NPP structures have been improved at JINS (Japan Institute of Nuclear Safety), one of the departments of NUPEC (Nuclear Power Engineering Test Center) in Japan. These codes are soil-spring lumped-mass code (SANLUM), finite element code (SANSSI), thin layered element code (SANSOL). In proceeding with the improvement of the analytical codes, in-situ large-scale forced vibration SSI tests were performed using models simulating light water reactor buildings, and simulation analyses were performed to verify the codes. This paper presents an analytical study to demonstrate the usefulness of the codes

  14. The guinea pig as an animal model for developmental and reproductive toxicology studies.

    Science.gov (United States)

    Rocca, Meredith S; Wehner, Nancy G

    2009-04-01

    Regulatory guidelines for developmental and reproductive toxicology (DART) studies require selection of "relevant" animal models as determined by kinetic, pharmacological, and toxicological data. Traditionally, rats, mice, and rabbits are the preferred animal models for these studies. However, for test articles that are pharmacologically inactive in the traditional animal models, the guinea pig may be a viable option. This choice should not be made lightly, as guinea pigs have many disadvantages compared to the traditional species, including limited historical control data, variability in pregnancy rates, small and variable litter size, long gestation, relative maturity at birth, and difficulty in dosing and breeding. This report describes methods for using guinea pigs in DART studies and provides results of positive and negative controls. Standard study designs and animal husbandry methods were modified to allow mating on the postpartum estrus in fertility studies and were used for producing cohorts of pregnant females for developmental studies. A positive control study with the pregnancy-disrupting agent mifepristone resulted in the anticipated failure of embryo implantation and supported the use of the guinea pig model. Control data for reproductive endpoints collected from 5 studies are presented. In cases where the traditional animal models are not relevant, the guinea pig can be used successfully for DART studies. (c) 2009 Wiley-Liss, Inc.

  15. Modeling the Responses to Resistance Training in an Animal Experiment Study

    Directory of Open Access Journals (Sweden)

    Antony G. Philippe

    2015-01-01

    Full Text Available The aim of the present study was to test whether systems models of training effects on performance in athletes can be used to explore the responses to resistance training in rats. 11 Wistar Han rats (277 ± 15 g underwent 4 weeks of resistance training consisting in climbing a ladder with progressive loads. Training amount and performance were computed from total work and mean power during each training session. Three systems models relating performance to cumulated training bouts have been tested: (i with a single component for adaptation to training, (ii with two components to distinguish the adaptation and fatigue produced by exercise bouts, and (iii with an additional component to account for training-related changes in exercise-induced fatigue. Model parameters were fitted using a mixed-effects modeling approach. The model with two components was found to be the most suitable to analyze the training responses (R2=0.53; P<0.001. In conclusion, the accuracy in quantifying training loads and performance in a rodent experiment makes it possible to model the responses to resistance training. This modeling in rodents could be used in future studies in combination with biological tools for enhancing our understanding of the adaptive processes that occur during physical training.

  16. Modeling study on geological environment at Horonobe URL site

    International Nuclear Information System (INIS)

    Shimo, Michito; Yamamoto, Hajime; Kumamoto, Sou; Fujiwara, Yasushi; Ono, Makoto

    2005-02-01

    The Horonobe underground research project has been operated by Japan Nuclear Cycle Development Institute to study the geological environment of sedimentary rocks in deep underground. The objectives of this study are to develop a geological environment model, which incorporate the current findings and the data obtained through the geological, geophysical, and borehole investigations at Horonobe site, and to predict the hydrological and geochemical impacts caused by the URL shaft excavation to the surrounding area. A three-dimensional geological structure model was constructed, integrating a large-scale model (25km x 15km) and a high-resolution site-scale model (4km x 4km) that have been developed by JNC. The constructed model includes surface topography, geologic formations (such as Yuchi, Koetoi, Wakkanai, and Masuporo Formations), and two major faults (Ohomagari fault and N1 fault). In hydrogeological modeling, water-conductive fractures identified in Wakkanai Formation are modeled stochastically using EHCM (Equivalent Heterogeneous Continuum Model) approach, to represent hydraulic heterogeneity and anisotropy in the fractured rock mass. Numerical code EQUIV FLO (Shimo et al., 1996), which is a 3D unsaturated-saturated groundwater simulator capable of EHCM, was used to simulate the regional groundwater flow. We used the same model and the code to predict the transient hydrological changes caused by the shaft excavations. Geochemical data in the Horonobe site such as water chemistries, mineral compositions of rocks were collected and summarized into digital datasets. M3 (Multivariate, Mixing and Mass-balance) method developed by SKB (Laaksoharju et al., 1999) was used to identify waters of different origins, and to infer the mixing ratio of these end-members to reproduce each sample's chemistry. Thermodynamic code such as RHREEQC, GWB, and EQ3/6 were used to model chemical reactions that explain the present minerals and aqueous concentrations observed in the site

  17. Study of alternative strategies to the task clarification activity of the market-pull product development process model

    OpenAIRE

    Motte, Damien

    2009-01-01

    A very large majority of the current product development process models put forward in textbooks present a homogenous structure, what Ulrich & Eppinger [1] call the market-pull model, presented as a generic one, while other possible product development process models are merely seen as variants. This paper focuses on the task clarification and derived activities (mainly the systematic search for customer needs through market study and the supplementary development costs it entails) and in...

  18. A study on basic theory for CDCC method for three-body model of deuteron scattering

    International Nuclear Information System (INIS)

    Kawai, Mitsuji

    1988-01-01

    Recent studies have revealed that the CDCC method is valid for treating the decomposition process involved in deuteron scattering on the basis of a three-body model. However, theoretical support has not been developed for this method. The present study is aimed at determining whether a solution by the CDCC method can be obtained 'correctly' from a 'realistic' model Hamiltonian for deuteron scattering. Some researchers have recently pointed out that there are some problems with the conventional CDCC calculation procedure in view of the general scattering theory. These problems are associated with asymptotic froms of the wave functions, convergence of calculations, and boundary conditions. Considerations show that the problem with asymptotic forms of the wave function is not a fatal defect, though some compromise is necessary. The problem with the convergence of calculations is not very serious either. Discussions are made of the handling of boundary conditions. Thus, the present study indicates that the CDCC method can be applied satisfactorily to actual deuteron scattering, and that the model wave function for the CDCC method is consistent with the model Hamiltonian. (Nogami, K.)

  19. Study of Z' {yields} e{sup +}e{sup -} in full simulation with regard to discrimination between models beyond the standard model

    Energy Technology Data Exchange (ETDEWEB)

    Schafer, M

    2004-09-01

    Although experimental results so far agree with predictions of the standard model, it is widely felt to be incomplete. Many prospective theories beyond the standard model predict extra neutral gauge bosons, denoted by Z', which might be light enough to be accessible at the LHC. Observables sensitive to the properties of these extra gauge bosons might be used to discriminate between the different theories beyond the standard model. In the present work several of these observables (total decay width, leptonic cross-section and forward-backward asymmetries) are studied at generation level and with a full simulation in the ATLAS detector. The Z' {yields} e{sup +}e{sup -} decay channel was chosen and 2 values for the mass of Z': 1.5 TeV and 4 TeV. Background is studied as well and it is confirmed that a Z' boson could easily be discovered at the chosen masses. It is shown that even in full simulation the studied observables can be determined with a good precision. In a next step a discrimination strategy has to be developed given the presented methods to extract the variables and their precision. (author)

  20. Into the intracellular logistics of cross-presentation

    Directory of Open Access Journals (Sweden)

    Charlotte eSadaka

    2012-02-01

    Full Text Available The induction of cytotoxic CD8+ T cell responses requires the presentation of antigenic peptides by MHC class I molecules (MHC I. MHC I usually present peptides derived from endogenous proteins. However, some subtypes of dendritic cells (DCs have developed the ability to efficiently present peptides derived from exogenous antigens on MHC I via a process called cross-presentation. Cross-presentation is intimately linked to the induction of anti-viral, -bacterial and -tumor cytotoxic T cell (CTL responses, as well as a wide variety of CTL-mediated diseases and transplant rejections. The molecular and cellular mechanisms underlying cross-presentation have been studied intensively since its original description, yet understanding of this process is incomplete and on the forefront of immunological research. Numerous pathways and models, some of them conflicting, have been described so far. Here, we review the various pathways reported as involved in cross-presentation, highlighting the complexity of this process. We also discuss in detail the different intracellular steps required, from antigen capture and routing, to processing and finally peptide loading, emphasizing the need for a better understanding of the cell biology of this phenomenon.

  1. Perfectionistic Self-Presentation, Socially Prescribed Perfectionism, and Suicide in Youth: A Test of the Perfectionism Social Disconnection Model

    Science.gov (United States)

    Roxborough, Heather M.; Hewitt, Paul L.; Kaldas, Janet; Flett, Gordon L.; Caelian, Carmen M.; Sherry, Simon; Sherry, Dayna L.

    2012-01-01

    The role of interpersonal components of perfectionism in suicide outcomes among youth was assessed and the Perfectionism Social Disconnection Model (PSDM) was tested by determining whether the links between socially prescribed perfectionism (SPP) and perfectionistic self-presentation (PSP) and suicide outcomes are mediated by experiences of social…

  2. A distribution planning model for natural gas supply chain: A case study

    International Nuclear Information System (INIS)

    Hamedi, Maryam; Zanjirani Farahani, Reza; Husseini, Mohammad Moattar; Esmaeilian, Gholam Reza

    2009-01-01

    In this paper, a real-world case study of a natural gas supply chain is investigated. By using concepts related to natural gas industry and the relations among the components of transmission and distribution network, a six-level supply chain has been introduced and presented schematically. The defined supply chain is a single-objective, multi-period, and single-product problem that is formulated as a mixed integer non-linear programming model, which can easily be linearized. The objective of this model is to minimize direct or indirect distribution costs. There are six groups of constraints including capacity, input and output balancing, demand satisfaction, network flow continuity, and relative constraints to the required binary variables. The solution algorithm of the problem is hierarchical; in each step, one section of the problem is solved using an exact method; the outputs of this section are passed to the next relative section as inputs. Finally, it is shown that the problem has been solved in a reasonable time and desirable results are attained. The use of proposed model and its solution approach have been studied in two gas trunk lines, to present the priority of its cost saving

  3. A Multi-scale Modeling System with Unified Physics to Study Precipitation Processes

    Science.gov (United States)

    Tao, W. K.

    2017-12-01

    In recent years, exponentially increasing computer power has extended Cloud Resolving Model (CRM) integrations from hours to months, the number of computational grid points from less than a thousand to close to ten million. Three-dimensional models are now more prevalent. Much attention is devoted to precipitating cloud systems where the crucial 1-km scales are resolved in horizontal domains as large as 10,000 km in two-dimensions, and 1,000 x 1,000 km2 in three-dimensions. Cloud resolving models now provide statistical information useful for developing more realistic physically based parameterizations for climate models and numerical weather prediction models. It is also expected that NWP and mesoscale model can be run in grid size similar to cloud resolving model through nesting technique. Recently, a multi-scale modeling system with unified physics was developed at NASA Goddard. It consists of (1) a cloud-resolving model (Goddard Cumulus Ensemble model, GCE model), (2) a regional scale model (a NASA unified weather research and forecast, WRF), and (3) a coupled CRM and global model (Goddard Multi-scale Modeling Framework, MMF). The same microphysical processes, long and short wave radiative transfer and land processes and the explicit cloud-radiation, and cloud-land surface interactive processes are applied in this multi-scale modeling system. This modeling system has been coupled with a multi-satellite simulator to use NASA high-resolution satellite data to identify the strengths and weaknesses of cloud and precipitation processes simulated by the model. In this talk, a review of developments and applications of the multi-scale modeling system will be presented. In particular, the results from using multi-scale modeling system to study the precipitation, processes and their sensitivity on model resolution and microphysics schemes will be presented. Also how to use of the multi-satellite simulator to improve precipitation processes will be discussed.

  4. Nursing education in Iran: past, present, and future.

    Science.gov (United States)

    Tabari Khomeiran, Rasoul; Deans, Cecil

    2007-10-01

    Nursing education in Iran has undergone significant change since its genesis with foreign missionaries over one hundred years ago. More recently, following the 1979 Islamic revolution, nurse education has followed the direction taken by most other countries in moving from an apprenticeship model of training to an academic model. A series of transformative changes to nursing education specifically-and across the higher education system generally-has resulted in nurses now being able to undertake study across all university-based programs up to and including doctoral level. Contemporary nursing students have access to full-text professional journals through the internet, and they may pursue their doctoral studies in other countries. Although these improvements in nursing education in Iran are to be applauded, much more needs to be accomplished to ensure that highly competent nurse practitioners continue to be produced in this country. This article presents an historical overview of the development of nursing education in Iran, within its economic and sociopolitical contexts. Recommendations based upon lessons learned from historical and contemporary realities are presented in order to advance nursing education in this part of world.

  5. A general framework for the evaluation of genetic association studies using multiple marginal models

    DEFF Research Database (Denmark)

    Kitsche, Andreas; Ritz, Christian; Hothorn, Ludwig A.

    2016-01-01

    OBJECTIVE: In this study, we present a simultaneous inference procedure as a unified analysis framework for genetic association studies. METHODS: The method is based on the formulation of multiple marginal models that reflect different modes of inheritance. The basic advantage of this methodology...

  6. Two-Dimensional Depth-Averaged Beach Evolution Modeling: Case Study of the Kizilirmak River Mouth, Turkey

    DEFF Research Database (Denmark)

    Baykal, Cüneyt; Ergin, Ayşen; Güler, Işikhan

    2014-01-01

    investigated by satellite images, physical model tests, and one-dimensional numerical models. The current study uses a two-dimensional depth-averaged numerical beach evolution model, developed based on existing methodologies. This model is mainly composed of four main submodels: a phase-averaged spectral wave......This study presents an application of a two-dimensional beach evolution model to a shoreline change problem at the Kizilirmak River mouth, which has been facing severe coastal erosion problems for more than 20 years. The shoreline changes at the Kizilirmak River mouth have been thus far...... transformation model, a two-dimensional depth-averaged numerical waveinduced circulation model, a sediment transport model, and a bottom evolution model. To validate and verify the numerical model, it is applied to several cases of laboratory experiments. Later, the model is applied to a shoreline change problem...

  7. Neuronal Models for Studying Tau Pathology

    Directory of Open Access Journals (Sweden)

    Thorsten Koechling

    2010-01-01

    Full Text Available Alzheimer's disease (AD is the most frequent neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main pathological hallmarks in the brain: senile plaques containing -amyloid peptide and neurofibrillary tangles (NFTs, consisting of fibrillar polymers of abnormally phosphorylated tau protein. Both of these histological characteristics of the disease have been simulated in genetically modified animals, which today include numerous mouse, fish, worm, and fly models of AD. The objective of this review is to present some of the main animal models that exist for reproducing symptoms of the disorder and their advantages and shortcomings as suitable models of the pathological processes. Moreover, we will discuss the results and conclusions which have been drawn from the use of these models so far and their contribution to the development of therapeutic applications for AD.

  8. Phytochemical analysis and docking study of compounds present in a polyherbal preparation used in the treatment of dermatophytosis.

    Science.gov (United States)

    Simhadri Vsdna, Nagesh; Muniappan, Muthuchamy; Kannan, Iyanar; Viswanathan, Subramanyam

    2017-12-01

    Soleshine is a polyherbal preparation established in the market for the treatment of cracks and tinea pedis, which is applied externally. This preparation is composed of the extracts of indigenous plants, namely Azadirachta indica, Lawsonia alba, and Shorea robusta , mixed with castor oil and sesame oil. In the present study, an attempt was made to identify the constituents of soleshine and identify some potential drug-like molecules that can inhibit important drug targets of the dermatophytes using molecular docking method. The active ingredients of polyherbal preparation were identified with the aid of gas chromatography-mass spectrometry (GC-MS). Two major compounds were selected based on the retention time and percentage of the area covered in the graph for docking study. The three-dimensional structures of 1,3-β-glucan synthase, chitinase, fungalysin, and lumazine synthase were derived by homology modelling using MODELLER software, version 9.0. The docking of the ligand and receptor was performed using iGEMDOCK and AutodockVina software. The physicochemical properties, lipophilicity, hydrophilicity, and drug likeness properties were obtained from the Swiss ADME online server tool. The GC-MS analysis demonstrated the presence of different phytochemical compounds in the extract of polyherbal preparation. A total of 20 compounds were identified, among which 3,7-dimethyl-2,6-octadienaland 2-pentene-2-methyl were the major compounds. Regarding 3,7-dimethyl-2,6-octadienal, the covered area and height were 40.15% and 46.17%, respectively. These values were 31.90% and 23.33% for 2-pentene-2-methyl, respectively. These two major compounds had an excellent binding affinity and obeyed the rules for the drug likeness and lead likeness. As the findings indicated, the two major ingredients present in soleshine showed a good antifungal activity as they inhibited the enzymes responsible for the survival of fungal organism; furthermore, they were appropriate for the lead

  9. Mathematical and computational modeling and simulation fundamentals and case studies

    CERN Document Server

    Moeller, Dietmar P F

    2004-01-01

    Mathematical and Computational Modeling and Simulation - a highly multi-disciplinary field with ubiquitous applications in science and engineering - is one of the key enabling technologies of the 21st century. This book introduces to the use of Mathematical and Computational Modeling and Simulation in order to develop an understanding of the solution characteristics of a broad class of real-world problems. The relevant basic and advanced methodologies are explained in detail, with special emphasis on ill-defined problems. Some 15 simulation systems are presented on the language and the logical level. Moreover, the reader can accumulate experience by studying a wide variety of case studies. The latter are briefly described within the book but their full versions as well as some simulation software demos are available on the Web. The book can be used for University courses of different level as well as for self-study. Advanced sections are marked and can be skipped in a first reading or in undergraduate courses...

  10. Intuitionistic Assessment Of Behavioural Present Value*

    OpenAIRE

    Piasecki Krzysztof

    2014-01-01

    The article discussesd the impact of chosen behavioural factors on the imprecision of present value assessment. The formal model of behavioural present value is offered as a result of this discussion. The behavioural present value is described here as an intuitionistic fuzzy set. The significance of the replacement of a fuzzy set by an intuitionistic fuzzy set is proved.

  11. Studies on top-quark Monte Carlo modelling for Top2016

    CERN Document Server

    The ATLAS collaboration

    2016-01-01

    This note summarises recent studies on Monte Carlo simulation setups of top-quark pair production used by the ATLAS experiment and presents a new method to deal with interference effects for the $Wt$ single-top-quark production which is compared against previous techniques. The main focus for the top-quark pair production is on the improvement of the modelling of the Powheg generator interfaced to the Pythia8 and Herwig7 shower generators. The studies are done using unfolded data at centre-of-mass energies of 7, 8, and 13 TeV.

  12. Modelling of protective actions in the German Risk Study (FRG)

    International Nuclear Information System (INIS)

    Burkart, A.K.

    1981-01-01

    An emergency response model for nuclear accidents has to allow for a great number of widely different emergency conditions. In addition, it should be compatible with the pertinent laws, regulations, ordinances, guidelines, criteria and reference levels. The German (FRG) guidelines are basic and flexible rather than precise, many decisions being left to the emergency management. In the Risk Study these decisions had to be anticipated. After a brief discussion of the basis of the emergency response model employed in the German Risk Study (FRG), the essential requirements to be met are listed. The main part of the paper deals with the rationale and specification of protective actions. As a result of the calculations the numbers of persons and sizes of areas involved in protective actions are presented. The last section deals with the variation of input data. (author)

  13. Studying the Impact of Distributed Solar PV on Power Systems using Integrated Transmission and Distribution Models: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Jain, Himanshu [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Palmintier, Bryan S [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Krad, Ibrahim [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Krishnamurthy, Dheepak [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-08-24

    This paper presents the results of a distributed solar PV impact assessment study that was performed using a synthetic integrated transmission (T) and distribution (D) model. The primary objective of the study was to present a new approach for distributed solar PV impact assessment, where along with detailed models of transmission and distribution networks, consumer loads were modeled using the physics of end-use equipment, and distributed solar PV was geographically dispersed and connected to the secondary distribution networks. The highlights of the study results were (i) increase in the Area Control Error (ACE) at high penetration levels of distributed solar PV; and (ii) differences in distribution voltages profiles and voltage regulator operations between integrated T&D and distribution only simulations.

  14. A Study on the Models for Corporate Social Responsibility of Small and Medium Enterprises

    Science.gov (United States)

    Ma, Jun

    The role of small and medium enterprises (SMEs) in corporate social responsibility (CSR) has attracted increasing attention and interest in recent years. The purpose of this study is to build some relevant models of CSR which are the foundations of empirical study later. The paper begins by an overview of the CSR literature in the context of seven step model for CSR and differences between corporate and small businesses. Noting the general lack of theoretical framework in the literature, the paper then presents relevant theoretical models of CSR that could be useful in conducting further research on CSR and SMEs. The study is qualitative in nature, capitalizing on a comparative research design to highlight differences in CSR orientations between SMEs and MNCs. The research is presented and implications are drawn regarding the peculiar relational attributes of SMEs in the context of CSR generally, and developing countries more specifically, and how this inclination can be further nurtured and leveraged. Further research can seek to highlight how to leverage this natural affinity to CSR among SMEs detected in this study in pursuit of more systematic engagement and more benefits.

  15. NATO Advanced Study Institute on Advanced Physical Oceanographic Numerical Modelling

    CERN Document Server

    1986-01-01

    This book is a direct result of the NATO Advanced Study Institute held in Banyuls-sur-mer, France, June 1985. The Institute had the same title as this book. It was held at Laboratoire Arago. Eighty lecturers and students from almost all NATO countries attended. The purpose was to review the state of the art of physical oceanographic numerical modelling including the parameterization of physical processes. This book represents a cross-section of the lectures presented at the ASI. It covers elementary mathematical aspects through large scale practical aspects of ocean circulation calculations. It does not encompass every facet of the science of oceanographic modelling. We have, however, captured most of the essence of mesoscale and large-scale ocean modelling for blue water and shallow seas. There have been considerable advances in modelling coastal circulation which are not included. The methods section does not include important material on phase and group velocity errors, selection of grid structures, advanc...

  16. Eocene climate and Arctic paleobathymetry: A tectonic sensitivity study using GISS ModelE-R

    Science.gov (United States)

    Roberts, C. D.; Legrande, A. N.; Tripati, A. K.

    2009-12-01

    The early Paleogene (65-45 million years ago, Ma) was a ‘greenhouse’ interval with global temperatures warmer than any other time in the last 65 Ma. This period was characterized by high levels of CO2, warm high-latitudes, warm surface-and-deep oceans, and an intensified hydrological cycle. Sediments from the Arctic suggest that the Eocene surface Arctic Ocean was warm, brackish, and episodically enabled the freshwater fern Azolla to bloom. The precise mechanisms responsible for the development of these conditions remain uncertain. We present equilibrium climate conditions derived from a fully-coupled, water-isotope enabled, general circulation model (GISS ModelE-R) configured for the early Eocene. We also present model-data comparison plots for key climatic variables (SST and δ18O) and analyses of the leading modes of variability in the tropical Pacific and North Atlantic regions. Our tectonic sensitivity study indicates that Northern Hemisphere climate would have been very sensitive to the degree of oceanic exchange through the seaways connecting the Arctic to the Atlantic and Tethys. By restricting these seaways, we simulate freshening of the surface Arctic Ocean to ~6 psu and warming of sea-surface temperatures by 2°C in the North Atlantic and 5-10°C in the Labrador Sea. Our results may help explain the occurrence of low-salinity tolerant taxa in the Arctic Ocean during the Eocene and provide a mechanism for enhanced warmth in the north western Atlantic. We also suggest that the formation of a volcanic land-bridge between Greenland and Europe could have caused increased ocean convection and warming of intermediate waters in the Atlantic. If true, this result is consistent with the theory that bathymetry changes may have caused thermal destabilisation of methane clathrates in the Atlantic.

  17. Life-cycle studies of biodiesel in Europe: A review addressing the variability of results and modeling issues

    International Nuclear Information System (INIS)

    Malca, Joao; Freire, Fausto

    2011-01-01

    Renewable energy sources, and particularly biofuels, are being promoted as possible solutions to address global warming and the depletion of petroleum resources. Nevertheless, significant disagreement and controversies exist regarding the actual benefits of biofuels displacing fossil fuels, as shown by a large number of life-cycle studies that have varying and sometimes contradictory conclusions. This article presents a comprehensive review of life-cycle studies of biodiesel in Europe. Studies have been compared in terms of nonrenewable primary energy requirement and GHG intensity of biodiesel. Recently published studies negate the definite and deterministic advantages for biodiesel presented in former studies. A high variability of results, particularly for biodiesel GHG intensity, with emissions ranging from 15 to 170 gCO 2 eq MJ f -1 has been observed. A detailed assessment of relevant aspects, including major assumptions, modeling choices and results, has been performed. The main causes for this high variability have been investigated, with emphasis on modeling choices. Key issues found are treatment of co-product and land use modeling, including high uncertainty associated with N 2 O and carbon emissions from cultivated soil. Furthermore, a direct correlation between how soil emissions were modeled and increasing values for calculated GHG emission has been found. A robust biodiesel life-cycle modeling has been implemented and the main sources of uncertainty have been investigated to show how uncertainty can be addressed to improve the transparency and reliability of results. Recommendations for further research work concerning the improvement of biofuel life cycle modeling are also presented. (author)

  18. Field studies and modeling of chemical processes in the unsaturated zone

    International Nuclear Information System (INIS)

    Polzer, W.L.; Fuentes, H.R.

    1985-01-01

    Technical assistance is being provided to Nuclear Materials Safety and Safeguards of the Nuclear Regulatory Commission to evaluate the validity of several guidelines listed in 10 CFR Part 61 for the future burial of low-level radioactive waste. Those guidelines include the requirement that the burial site shall be capable of being modeled. Both laboratory- and field-scale studies are being conducted under unsaturated moisture conditions and under steady-state and unsteady-state flow conditions. This paper reviews the kinds of present experiments in low-level radioactive waste disposal in development at the Los Alamos National Laboratory. Major emphasis is on some of the initial analyses of data for laboratory sorption experiments and for field transport tests. Brief reference is made to leaching and transport studies. Laboratory batch equilibrium sorption studies suggest that adsorption of nonconservative tracers can be described in terms of two empirical constants; one gives an indication of the average K/sub d/ for all adsorption sites and the other gives an indication of the spread of individual K/sub d/'s about the average K/sub d/. This information can be translated into a ''chemical dispersion'' under dynamic flow and equilibrium sorption conditions that is in addition to the traditionally accepted physical dispersion. Laboratory nonequilibrium sorption studies suggest that nonequilibrium models may be needed to model the transport of the nonconservative tracers cobalt and cesium; equilibrium models should be suitable to model strontium transport. Analyses from field-scale studies indicate that conservative tracers can reasonably be modeled with a one-dimensional advective-dispersive equation for steady flow. 12 figs., 1 tab

  19. Barriers to cancer symptom presentation among people from low socioeconomic groups: a qualitative study

    Directory of Open Access Journals (Sweden)

    Grace McCutchan

    2016-10-01

    Full Text Available Abstract Background Socioeconomic inequalities in cancer survival can in part be explained by long patient intervals among people from deprived groups; however, the reasons for this are unclear. This qualitative study explores the actual and anticipated barriers to cancer symptom presentation in the context of socioeconomic deprivation. Methods Thirty participants were recruited through the International Cancer Benchmarking Partnership Welsh database (n = 20, snowball sampling (n = 8 and community partners (n = 2. Semi-structured qualitative interviews were conducted with symptomatic and asymptomatic adults over the age of 50 years, who were identified as being from a low socioeconomic group based on multiple individual and group level indicators. Transcripts were analysed using a Framework approach based on the COM-B model (Capability, Opportunity, Motivation-Behaviour. Results There was evidence of poor awareness of non-specific cancer symptoms (Capability, fearful and fatalistic beliefs about cancer (Motivation, and various barriers to accessing an appointment with the family physician (Opportunity and full disclosure of symptoms (Capability. These in combination were associated with a lengthened patient interval among participants. Social networks (Opportunity were influential on the formation of knowledge and beliefs about cancer. Participants’ behavioural and normative beliefs were usually formed and reinforced by people they knew with cancer, and such beliefs were considered to lengthen the patient interval. Discussing symptoms with a family member or friend before a visit to the family physician was the norm, and could act as a barrier or facilitator depending on the quality of advice given (Opportunity. Economic hardship meant fulfilling basic day-to-day needs such as finding money for food were prioritised over medical help seeking (Opportunity. Conclusions The complex interaction between individual characteristics and

  20. Development of a railway wagon-track interaction model: Case studies on excited tracks

    Science.gov (United States)

    Xu, Lei; Chen, Xianmai; Li, Xuwei; He, Xianglin

    2018-02-01

    In this paper, a theoretical framework for modeling the railway wagon-ballast track interactions is presented, in which the dynamic equations of motion of wagon-track systems are constructed by effectively coupling the linear and nonlinear dynamic characteristics of system components. For the linear components, the energy-variational principle is directly used to derive their dynamic matrices, while for the nonlinear components, the dynamic equilibrium method is implemented to deduce the load vectors, based on which a novel railway wagon-ballast track interaction model is developed, and being validated by comparing with the experimental data measured from a heavy haul railway and another advanced model. With this study, extensive contributions in figuring out the critical speed of instability, limits and localizations of track irregularities over derailment accidents are presented by effectively integrating the dynamic simulation model, the track irregularity probabilistic model and time-frequency analysis method. The proposed approaches can provide crucial information to guarantee the running safety and stability of the wagon-track system when considering track geometries and various running speeds.

  1. Kuala Kemaman hydraulic model study

    International Nuclear Information System (INIS)

    Abdul Kadir Ishak

    2005-01-01

    There The problems facing the area of Kuala Kemaman are siltation and erosion at shoreline. The objectives of study are to assess the best alignment of the groyne alignment, to ascertain the most stable shoreline regime and to investigate structural measures to overcome the erosion. The scope of study are data collection, wave analysis, hydrodynamic simulation and sediment transport simulation. Numerical models MIKE 21 are used - MIKE 21 NSW, for wind-wave model, which describes the growth, decay and transformation of wind-generated waves and swell in nearshore areas. The study takes into account effects of refraction and shoaling due to varying depth, energy dissipation due to bottom friction and wave breaking, MIKE 21 HD - modelling system for 2D free-surface flow which to stimulate the hydraulics phenomena in estuaries, coastal areas and seas. Predicted tidal elevation and waves (radiation stresses) are considered into study while wind is not considered. MIKE 21 ST - the system that calculates the rates of non-cohesive (sand) sediment transport for both pure content and combined waves and current situation

  2. Modeling the geographical studies with GeoGebra-software

    Directory of Open Access Journals (Sweden)

    Ionica Soare

    2010-01-01

    Full Text Available The problem of mathematical modeling in geography is one of the most important strategies in order to establish the evolution and the prevision of geographical phenomena. Models must have a simplified structure, to reflect essential components and must be selective, structured, and suggestive and approximate the reality. Models could be static or dynamic, developed in a theoretical, symbolic, conceptual or mental way, mathematically modeled. The present paper is focused on the virtual model which uses GeoGebra software, free and available at www.geogebra.org, in order to establish new methods of geographical analysis in a dynamic, didactic way.

  3. Comparison of Bolton analysis and Little’s irregularity index on laser scanned three-dimensional digital study models with conventional study models

    Science.gov (United States)

    Kurnia, H.; Noerhadi, N. A. I.

    2017-08-01

    Three-dimensional digital study models were introduced following advances in digital technology. This study was carried out to assess the reliability of digital study models scanned by a laser scanning device newly assembled. The aim of this study was to compare the digital study models and conventional models. Twelve sets of dental impressions were taken from patients with mild-to-moderate crowding. The impressions were taken twice, one with alginate and the other with polyvinylsiloxane. The alginate impressions were made into conventional models, and the polyvinylsiloxane impressions were scanned to produce digital models. The mesiodistal tooth width and Little’s irregularity index (LII) were measured manually with digital calipers on the conventional models and digitally on the digital study models. Bolton analysis was performed on each study models. Each method was carried out twice to check for intra-observer variability. The reproducibility (comparison of the methods) was assessed using independent-sample t-tests. The mesiodistal tooth width between conventional and digital models did not significantly differ (p > 0.05). Independent-sample t-tests did not identify statistically significant differences for Bolton analysis and LII (p = 0.603 for Bolton and p = 0894 for LII). The measurements of the digital study models are as accurate as those of the conventional models.

  4. An SIV/macaque model targeted to study HIV-associated neurocognitive disorders.

    Science.gov (United States)

    Beck, Sarah E; Queen, Suzanne E; Metcalf Pate, Kelly A; Mangus, Lisa M; Abreu, Celina M; Gama, Lucio; Witwer, Kenneth W; Adams, Robert J; Zink, M Christine; Clements, Janice E; Mankowski, Joseph L

    2018-04-01

    Simian immunodeficiency virus (SIV) infection of pigtailed macaques is a highly representative and well-characterized animal model for HIV neuropathogenesis studies that provides an excellent opportunity to study and develop prognostic markers of HIV-associated neurocognitive disorders (HAND) for HIV-infected individuals. SIV studies can be performed in a controlled setting that enhances reproducibility and offers high-translational value. Similar to observations in HIV-infected patients receiving antiretroviral therapy (ART), ongoing neurodegeneration and inflammation are present in SIV-infected pigtailed macaques treated with suppressive ART. By developing quantitative viral outgrowth assays that measure both CD4+ T cells and macrophages harboring replication competent SIV as well as a highly sensitive mouse-based viral outgrowth assay, we have positioned the SIV/pigtailed macaque model to advance our understanding of latent cellular reservoirs, including potential CNS reservoirs, to promote HIV cure. In addition to contributing to our understanding of the pathogenesis of HAND, the SIV/pigtailed macaque model also provides an excellent opportunity to test innovative approaches to eliminate the latent HIV reservoir in the brain.

  5. Testing a Poisson counter model for visual identification of briefly presented, mutually confusable single stimuli in pure accuracy tasks.

    Science.gov (United States)

    Kyllingsbæk, Søren; Markussen, Bo; Bundesen, Claus

    2012-06-01

    The authors propose and test a simple model of the time course of visual identification of briefly presented, mutually confusable single stimuli in pure accuracy tasks. The model implies that during stimulus analysis, tentative categorizations that stimulus i belongs to category j are made at a constant Poisson rate, v(i, j). The analysis is continued until the stimulus disappears, and the overt response is based on the categorization made the greatest number of times. The model was evaluated by Monte Carlo tests of goodness of fit against observed probability distributions of responses in two extensive experiments and also by quantifications of the information loss of the model compared with the observed data by use of information theoretic measures. The model provided a close fit to individual data on identification of digits and an apparently perfect fit to data on identification of Landolt rings.

  6. Modelling studies for the assessment of the Advanced Cold Process Canister

    International Nuclear Information System (INIS)

    Henshaw, J.; Hoch, A.R.; Sharland, S.M.

    1991-01-01

    The Advanced Cold Process Canister (ACPC) is a new concept for the encapsulation of spent nuclear fuel for geological disposal. It consists of steel canister encased in a copper overpack. In this paper, modelling studies to assess the performance of the ACPC under repository conditions are presented. The production of nitric acid and ammonia through radiolysis of any water remaining inside the canister under fault conditions has been examined in this study. However, results suggest that only low levels are possible, and the risk of stress-corrosion cracking is considered small. The corrosion behavior subsequent to a breach in the outer canister was also considered. A model was constructed to predict the hydrogen gas production due to corrosion reactions, and evolution of the corrosion behavior

  7. Evaluation of a present-day climate simulation with a new coupled atmosphere-ocean model GENMOM

    Directory of Open Access Journals (Sweden)

    J. R. Alder

    2011-02-01

    Full Text Available We present a new, non-flux corrected AOGCM, GENMOM, that combines the GENESIS version 3 atmospheric GCM (Global Environmental and Ecological Simulation of Interactive Systems and MOM2 (Modular Ocean Model version 2 nominally at T31 resolution. We evaluate GENMOM by comparison with reanalysis products (e.g., NCEP2 and three models used in the IPCC AR4 assessment. GENMOM produces a global temperature bias of 0.6 °C. Atmospheric features such as the jet stream structure and major semi-permanent sea level pressure centers are well simulated as is the mean planetary-scale wind structure that is needed to produce the correct position of stormtracks. Most ocean surface currents are reproduced except where they are not resolvable at T31 resolution. Overall, GENMOM captures reasonably well the observed gradients and spatial distributions of annual surface temperature and precipitation and the simulations are on par with other AOGCMs. Deficiencies in the GENMOM simulations include a warm bias in the surface temperature over the southern oceans, a split in the ITCZ and weaker-than-observed overturning circulation.

  8. The FODA-TDMA satellite access scheme - Presentation, study of the system, and results

    Science.gov (United States)

    Celandroni, Nedo; Ferro, Erina

    1991-12-01

    A description is given of FODA-TDMA, a satellite access scheme designed for mixed traffic. The study of the system is presented and the choice of some parameters is justified. A simplified analytic solution is found, describing the steady-state behavior of the system. Some results of the simulation tests for an already existing hardware environment are also presented for the channel speeds of 2 and 8 Mb/s, considering both the stationary and the transient cases. The results of the experimentation at 2 Mb/s on the satellite Eutelsat-F2 are also presented and compared with the results of the simulation.

  9. Numerical study of corner separation in a linear compressor cascade using various turbulence models

    Directory of Open Access Journals (Sweden)

    Liu Yangwei

    2016-06-01

    Full Text Available Three-dimensional corner separation is a common phenomenon that significantly affects compressor performance. Turbulence model is still a weakness for RANS method on predicting corner separation flow accurately. In the present study, numerical study of corner separation in a linear highly loaded prescribed velocity distribution (PVD compressor cascade has been investigated using seven frequently used turbulence models. The seven turbulence models include Spalart–Allmaras model, standard k–ɛ model, realizable k–ɛ model, standard k–ω model, shear stress transport k–ω model, v2–f model and Reynolds stress model. The results of these turbulence models have been compared and analyzed in detail with available experimental data. It is found the standard k–ɛ model, realizable k–ɛ model, v2–f model and Reynolds stress model can provide reasonable results for predicting three dimensional corner separation in the compressor cascade. The Spalart–Allmaras model, standard k–ω model and shear stress transport k–ω model overestimate corner separation region at incidence of 0°. The turbulence characteristics are discussed and turbulence anisotropy is observed to be stronger in the corner separating region.

  10. A study on online monitoring system development using empirical models

    Energy Technology Data Exchange (ETDEWEB)

    An, Sang Ha

    2010-02-15

    Maintenance technologies have been progressed from a time-based to a condition-based manner. The fundamental idea of condition-based maintenance (CBM) is built on the real-time diagnosis of impending failures and/or the prognosis of residual lifetime of equipment by monitoring health conditions using various sensors. The success of CBM, therefore, hinges on the capability to develop accurate diagnosis/prognosis models. Even though there may be an unlimited number of methods to implement models, the models can normally be classified into two categories in terms of their origins: using physical principles or historical observations. I have focused on the latter method (sometimes referred as the empirical model based on statistical learning) because of some practical benefits such as context-free applicability, configuration flexibility, and customization adaptability. While several pilot-scale systems using empirical models have been applied to work sites in Korea, it should be noticed that these do not seem to be generally competitive against conventional physical models. As a result of investigating the bottlenecks of previous attempts, I have recognized the need for a novel strategy for grouping correlated variables such that an empirical model can accept not only statistical correlation but also some extent of physical knowledge of a system. Detailed examples of problems are as follows: (1) missing of important signals in a group caused by the lack of observations, (2) problems of signals with the time delay, (3) problems of optimal kernel bandwidth. In this study an improved statistical learning framework including the proposed strategy and case studies illustrating the performance of the method are presented.

  11. Variability of the 2014-present inflation source at Mauna Loa volcano revealed using time-dependent modeling

    Science.gov (United States)

    Johanson, I. A.; Miklius, A.; Okubo, P.; Montgomery-Brown, E. K.

    2017-12-01

    Mauna Loa volcano is the largest active volcano on earth and in the 20thcentury produced roughly one eruption every seven years. The 33-year quiescence since its last eruption 1984 has been punctuated by three inflation episodes where magma likely entered the shallow plumbing system, but was not erupted. The most recent began in 2014 and is ongoing. Unlike prior inflation episodes, the current one is accompanied by a significant increase in shallow seismicity, a pattern that is similar to earlier pre-eruptive periods. We apply the Kalman filter based Network Inversion Filter (NIF) to the 2014-present inflation episode using data from a 27 station continuous GPS network on Mauna Loa. The model geometry consists of a point volume source and tabular, dike-like body, which have previously been shown to provide a good fit to deformation data from a 2004-2009 inflation episode. The tabular body is discretized into 1km x 1km segments. For each day, the NIF solves for the rates of opening on the tabular body segments (subject to smoothing and positivity constraints), volume change rate in the point source, and slip rate on a deep décollement fault surface, which is constrained to a constant (no transient slip allowed). The Kalman filter in the NIF provides for smoothing both forwards and backwards in time. The model shows that the 2014-present inflation episode occurred as several sub-events, rather than steady inflation. It shows some spatial variability in the location of the inflation sub-events. In the model, opening in the tabular body is initially concentrated below the volcano's summit, in an area roughly outlined by shallow seismicity. In October, 2015 opening in the tabular body shifts to be centered beneath the southwest portion of the summit and seismicity becomes concentrated in this area. By late 2016, the opening rate on the tabular body decreases and is once again under the central part of summit. This modeling approach has allowed us to track these

  12. Stroke Mortality, Clinical Presentation and Day of Arrival: The Atherosclerosis Risk in Communities (ARIC Study

    Directory of Open Access Journals (Sweden)

    Emily C. O'Brien

    2011-01-01

    Full Text Available Background. Recent studies report that acute stroke patients who present to the hospital on weekends have higher rates of 28-day mortality than similar patients who arrive during the week. However, how this association is related to clinical presentation and stroke type has not been systematically investigated. Methods and Results. We examined the association between day of arrival and 28-day mortality in 929 validated stroke events in the ARIC cohort from 1987–2004. Weekend arrival was defined as any arrival time from midnight Friday until midnight Sunday. Mortality was defined as all-cause fatal events from the day of arrival through the 28th day of followup. The presence or absence of thirteen stroke signs and symptoms were obtained through medical record review for each event. Binomial logistic regression was used to estimate odds ratios and 95% confidence intervals (OR; 95% CI for the association between weekend arrival and 28-day mortality for all stroke events and for stroke subtypes. The overall risk of 28-day mortality was 9.6% for weekday strokes and 10.1% for weekend strokes. In models controlling for patient demographics, clinical risk factors, and event year, weekend arrival was not associated with 28-day mortality (0.87; 0.51, 1.50. When stratified by stroke type, weekend arrival was not associated with increased odds of mortality for ischemic (1.17, 0.62, 2.23 or hemorrhagic (0.37; 0.11, 1.26 stroke patients. Conclusions. Presence or absence of thirteen signs and symptoms was similar for weekday patients and weekend patients when stratified by stroke type. Weekend arrival was not associated with 28-day all-cause mortality or differences in symptom presentation for strokes in this cohort.

  13. Process modeling for the Integrated Thermal Treatment System (ITTS) study

    Energy Technology Data Exchange (ETDEWEB)

    Liebelt, K.H.; Brown, B.W.; Quapp, W.J.

    1995-09-01

    This report describes the process modeling done in support of the integrated thermal treatment system (ITTS) study, Phases 1 and 2. ITTS consists of an integrated systems engineering approach for uniform comparison of widely varying thermal treatment technologies proposed for treatment of the contact-handled mixed low-level wastes (MLLW) currently stored in the U.S. Department of Energy complex. In the overall study, 19 systems were evaluated. Preconceptual designs were developed that included all of the various subsystems necessary for a complete installation, from waste receiving through to primary and secondary stabilization and disposal of the processed wastes. Each system included the necessary auxiliary treatment subsystems so that all of the waste categories in the complex were fully processed. The objective of the modeling task was to perform mass and energy balances of the major material components in each system. Modeling of trace materials, such as pollutants and radioactive isotopes, were beyond the present scope. The modeling of the main and secondary thermal treatment, air pollution control, and metal melting subsystems was done using the ASPEN PLUS process simulation code, Version 9.1-3. These results were combined with calculations for the remainder of the subsystems to achieve the final results, which included offgas volumes, and mass and volume waste reduction ratios.

  14. Process modeling for the Integrated Thermal Treatment System (ITTS) study

    International Nuclear Information System (INIS)

    Liebelt, K.H.; Brown, B.W.; Quapp, W.J.

    1995-09-01

    This report describes the process modeling done in support of the integrated thermal treatment system (ITTS) study, Phases 1 and 2. ITTS consists of an integrated systems engineering approach for uniform comparison of widely varying thermal treatment technologies proposed for treatment of the contact-handled mixed low-level wastes (MLLW) currently stored in the U.S. Department of Energy complex. In the overall study, 19 systems were evaluated. Preconceptual designs were developed that included all of the various subsystems necessary for a complete installation, from waste receiving through to primary and secondary stabilization and disposal of the processed wastes. Each system included the necessary auxiliary treatment subsystems so that all of the waste categories in the complex were fully processed. The objective of the modeling task was to perform mass and energy balances of the major material components in each system. Modeling of trace materials, such as pollutants and radioactive isotopes, were beyond the present scope. The modeling of the main and secondary thermal treatment, air pollution control, and metal melting subsystems was done using the ASPEN PLUS process simulation code, Version 9.1-3. These results were combined with calculations for the remainder of the subsystems to achieve the final results, which included offgas volumes, and mass and volume waste reduction ratios

  15. Study of Z' {yields} e{sup +}e{sup -} in full simulation with regard to discrimination between models beyond the standard model

    Energy Technology Data Exchange (ETDEWEB)

    Schafer, M

    2004-09-01

    Although experimental results so far agree with predictions of the standard model, it is widely felt to be incomplete. Many prospective theories beyond the standard model predict extra neutral gauge bosons, denoted by Z', which might be light enough to be accessible at the LHC. Observables sensitive to the properties of these extra gauge bosons might be used to discriminate between the different theories beyond the standard model. In the present work several of these observables (total decay width, leptonic cross-section and forward-backward asymmetries) are studied at generation level and with a full simulation in the ATLAS detector. The Z' {yields} e{sup +}e{sup -} decay channel was chosen and 2 values for the mass of Z': 1.5 TeV and 4 TeV. Background is studied as well and it is confirmed that a Z' boson could easily be discovered at the chosen masses. It is shown that even in full simulation the studied observables can be determined with a good precision. In a next step a discrimination strategy has to be developed given the presented methods to extract the variables and their precision. (author)

  16. Model studies with a 3-d global CTM using ECMWF data

    Energy Technology Data Exchange (ETDEWEB)

    Sundet, Jostein Kandal

    1997-12-31

    It has become evident during the last decades that the large-scale tropospheric distribution of chemical compounds is changing due to man-made emissions. These changes, in turn, lead to changes in the atmospheric oxidation capacity that may significantly affect the environment, such as global warming and increased acid rain. The main objective of this thesis was to use data from a meteorological weather prediction model to drive a global Chemical Tracer (or transport) Model (CTM), the Oslo CTM-2, where the data are generated at the European Centre for Medium-Range Weather Forecasts (ECMWF). It is the kind of data that are taken from the IFS model that is the innovative part of this study. In contrast to other studies, the purpose of the IFS model run is to generate selected data instead of using data from the ECMWF archive. This enabled the extraction of fields useful for atmospheric chemistry studies. The thesis describes the CTM-2 model, presents the data from the IFS model and briefly introduces tropospheric chemistry. Experiments are run to verify the model. The following points for improvements of the model are pointed out: (1) clouds must be included in the photodissociation calculations, (2) better boundary value representing the stratosphere must be obtained for ozone and probably NO and HNO{sub 3} as well, (3) the surface deposition scheme for ozone must be improved, and (4) fluctuations in the chemistry were found and should be eliminated through assessing the fast cycling of OH and HO{sub 2}. Some issues for consideration by the ECMWF are also pointed out. 57 refs., 24 figs., 16 tabs.

  17. CMBE v05-Implementation of a toy-model for chaos analysis of relativistic nuclear collisions at the present BNL energies

    Science.gov (United States)

    Grossu, I. V.; Felea, D.; Jipa, Al.; Besliu, C.; Stan, E.; Ristea, O.; Ristea, C.; Calin, M.; Esanu, T.; Bordeianu, C.; Tuturas, N.

    2014-11-01

    In this paper we present a new version of Chaos Many-Body Engine (CMBE) Grossu et al. (2014) [1]. Inspired by the Mean Free Path concept, we implemented a new parameter, namely the ;Mean Free Time;, which is defined as the mean time between one particle's creation and its stimulated decay. This new parameter should be understood as an effect of the nuclear environment and, as opposed to the particle lifetime, it has the advantage of not being affected by the relativistic dilation. In [2] we presented a toy-model for chaos analysis of relativistic nuclear collisions at 4.5 A GeV/c (the SKM 200 collaboration). In this work, we extended our model to 200 A GeV (the maximum BNL energy).

  18. Full text publication rates of studies presented at an international emergency medicine scientific meeting.

    Science.gov (United States)

    Chan, Jannet W M; Graham, Colin A

    2011-09-01

    The publication rate of full text papers following an abstract presentation at a medical conference is variable, and few studies have examined the situation with respect to international emergency medicine conferences. This retrospective study aimed to identify the publication rate of abstracts presented at the 2006 International Conference on Emergency Medicine (ICEM) held in Halifax, Canada. The full text publication rate was 33.2%, similar to previous emergency medicine meetings. English language barriers may play a role in the low publication rate seen.

  19. Modelling microbiological water quality in the Seine river drainage network: past, present and future situations

    Directory of Open Access Journals (Sweden)

    P. Servais

    2007-09-01

    Full Text Available The Seine river watershed is characterized by a high population density and intense agricultural activities. Data show low microbiological water quality in the main rivers (Seine, Marne, Oise of the watershed. Today, there is an increasing pressure from different social groups to restore microbiological water quality in order to both increase the safety of drinking water production and to restore the possible use of these rivers for bathing and rowing activities, as they were in the past. A model, appended to the hydro-ecological SENEQUE/Riverstrahler model describing the functioning of large river systems, was developed to describe the dynamics of faecal coliforms (FC, the most usual faecal contamination indicator. The model is able to calculate the distribution of FC concentrations in the whole drainage network resulting from land use and wastewater management in the watershed. The model was validated by comparing calculated FC concentrations with available field data for some well-documented situations in different river stretches of the Seine drainage network. Once validated, the model was used to test various predictive scenarios, as, for example, the impact of the modifications in wastewater treatment planned at the 2012 horizon in the Seine watershed in the scope of the implementation of the european water framework directive. The model was also used to investigate past situations. In particular, the variations of the microbiological water quality in the Parisian area due to population increase and modifications in wastewater management were estimated over the last century. It was shown that the present standards for bathing and other aquatic recreational activities are not met in the large tributaries upstream from Paris since the middle of the 1950's, and at least since the middle of the XIXth century in the main branch of the Seine river downstream from Paris. Efforts carried out for improving urban wastewater treatment in terms

  20. Model analyses of atmospheric mercury: present air quality and effects of transpacific transport on the United States

    Science.gov (United States)

    Lei, H.; Liang, X.-Z.; Wuebbles, D. J.; Tao, Z.

    2013-11-01

    Atmospheric mercury is a toxic air and water pollutant that is of significant concern because of its effects on human health and ecosystems. A mechanistic representation of the atmospheric mercury cycle is developed for the state-of-the-art global climate-chemistry model, CAM-Chem (Community Atmospheric Model with Chemistry). The model simulates the emission, transport, transformation and deposition of atmospheric mercury (Hg) in three forms: elemental mercury (Hg(0)), reactive mercury (Hg(II)), and particulate mercury (PHg). Emissions of mercury include those from human, land, ocean, biomass burning and volcano related sources. Land emissions are calculated based on surface solar radiation flux and skin temperature. A simplified air-sea mercury exchange scheme is used to calculate emissions from the oceans. The chemistry mechanism includes the oxidation of Hg(0) in gaseous phase by ozone with temperature dependence, OH, H2O2 and chlorine. Aqueous chemistry includes both oxidation and reduction of Hg(0). Transport and deposition of mercury species are calculated through adapting the original formulations in CAM-Chem. The CAM-Chem model with mercury is driven by present meteorology to simulate the present mercury air quality during the 1999-2001 period. The resulting surface concentrations of total gaseous mercury (TGM) are then compared with the observations from worldwide sites. Simulated wet depositions of mercury over the continental United States are compared to the observations from 26 Mercury Deposition Network stations to test the wet deposition simulations. The evaluations of gaseous concentrations and wet deposition confirm a strong capability for the CAM-Chem mercury mechanism to simulate the atmospheric mercury cycle. The general reproduction of global TGM concentrations and the overestimation on South Africa indicate that model simulations of TGM are seriously affected by emissions. The comparison to wet deposition indicates that wet deposition patterns

  1. Neonatal Seizure Models to Study Epileptogenesis

    Directory of Open Access Journals (Sweden)

    Yuka Kasahara

    2018-04-01

    Full Text Available Current therapeutic strategies for epilepsy include anti-epileptic drugs and surgical treatments that are mainly focused on the suppression of existing seizures rather than the occurrence of the first spontaneous seizure. These symptomatic treatments help a certain proportion of patients, but these strategies are not intended to clarify the cellular and molecular mechanisms underlying the primary process of epilepsy development, i.e., epileptogenesis. Epileptogenic changes include reorganization of neural and glial circuits, resulting in the formation of an epileptogenic focus. To achieve the goal of developing “anti-epileptogenic” drugs, we need to clarify the step-by-step mechanisms underlying epileptogenesis for patients whose seizures are not controllable with existing “anti-epileptic” drugs. Epileptogenesis has been studied using animal models of neonatal seizures because such models are useful for studying the latent period before the occurrence of spontaneous seizures and the lowering of the seizure threshold. Further, neonatal seizure models are generally easy to handle and can be applied for in vitro studies because cells in the neonatal brain are suitable for culture. Here, we review two animal models of neonatal seizures for studying epileptogenesis and discuss their features, specifically focusing on hypoxia-ischemia (HI-induced seizures and febrile seizures (FSs. Studying these models will contribute to identifying the potential therapeutic targets and biomarkers of epileptogenesis.

  2. GLOBAL CLIMATE MODEL:A COMPREHENSIVE TOOL IN CLIMATE CHANGE IMPACT STUDIES

    Directory of Open Access Journals (Sweden)

    Dharmaveer Singh

    2015-01-01

    Full Text Available There is growing concern, how and to what extent future changes in climate will affect human society and natural environments. Continuous emissions of Green House Gasses (GHGs at or above current rates will cause further warming. This, in turn, may modify global climate system during 21st century that very likely would have larger impacts than those observed during 20th century. At present, Global Climate Models (GCMs are only the most reliable tools available for studying behaviour of the climate system. This paper presents a comprehensive review of GCMs including their development and applications in climate change impacts studies. Following a discussion of the limitations of GCMs at regional and local scales, different approaches of downscaling are discussed in detail.

  3. A multi-centre cohort study evaluating the role of inflammatory markers in patient’s presenting with acute ureteric colic (MIMIC

    Directory of Open Access Journals (Sweden)

    T.T. Shah

    Full Text Available Background: Spontaneous Stone Passage (SSP rates in acute ureteric colic range from 47 to 75%. There is conflicting evidence on the role of raised inflammatory markers in acute ureteric colic. The use of an easily applicable biomarker that could predict SSP or need for intervention would improve the management of obstructing ureteric stones. Thus, there is a need to determine in an appropriately powered study, in patients who are initially managed conservatively, which factors at the time of acute admission can predict subsequent patient outcome such as SSP and the need for intervention. Particularly, establishing whether levels of white cell count (WBC at presentation are associated with likelihood of SSP or intervention may guide clinicians on the management of these patients’ stones. Design: Multi-center cohort study disseminated via the UK British Urology Researchers in Surgical Training (BURST and Australian Young Urology Researchers Organisation (YURO. Primary research question: What is the association between WBC and SSP in patients discharged from emergency department after initial conservative management? Patient population: Patients who have presented with acute renal colic with CT KUB evidence of a solitary ureteric stone. A minimum sample size of 720 patients across 15 centres will be needed. Hypothesis: A raised WBC is associated with decreased odds of spontaneous stone passage. Primary outcome: The occurrence of SSP within six months of presentation with acute ureteric colic (YES/NO. SSP was defined as absence of need for intervention to assist stone passage. Statistical analysis plan: A multivariable logistic regression model will be constructed, where the outcome of interest is SSP using data from patients who do not undergo intervention at presentation. A random effect will be used to account for clustering of patients within hospitals/institutions. The model will include adjustments for gender, age as control variables

  4. Effects of wind shear on the consequence model of the reactor safety study

    International Nuclear Information System (INIS)

    Sprung, J.L.; Church, H.W.

    1977-01-01

    The effects of explicit incorporation of wind shear into the consequence model of the Reactor Safety study have been investigated. The integral of exposure (X/Q) over area is unchanged by directional shear and decreased by speed shear. Consequence model predictions of early fatalities are always decreased by wind shear. Where early fatalities are decreased, survivors are subject to latent effects and, therefore, latent effects increase. However, aggregate early fatalities and latent effects always are decreased. Because the magnitude of these changes is within the present uncertainties of the consequence model, explicit incorporation of wind shear in the consequence model is not now warranted

  5. Backward Bifurcation in a Cholera Model: A Case Study of Outbreak in Zimbabwe and Haiti

    Science.gov (United States)

    Sharma, Sandeep; Kumari, Nitu

    In this paper, a nonlinear deterministic model is proposed with a saturated treatment function. The expression of the basic reproduction number for the proposed model was obtained. The global dynamics of the proposed model was studied using the basic reproduction number and theory of dynamical systems. It is observed that proposed model exhibits backward bifurcation as multiple endemic equilibrium points exist when R0 cholera in the community. We also obtain a unique endemic equilibria when R0 > 1. The global stability of unique endemic equilibria is performed using the geometric approach. An extensive numerical study is performed to support our analytical results. Finally, we investigate two major cholera outbreaks, Zimbabwe (2008-09) and Haiti (2010), with the help of the present study.

  6. Temperature effects on multiphase reactions of organic molecular markers: A modeling study

    Science.gov (United States)

    Pratap, Vikram; Chen, Ying; Yao, Guangming; Nakao, Shunsuke

    2018-04-01

    Various molecular markers are used in source apportionment studies. In early studies, molecular markers were assumed to be inert. However, recent studies suggest that molecular markers can decay rapidly through multiphase reactions, which makes interpretation of marker measurements challenging. This study presents a simplified model to account for the effects of temperature and relative humidity on the lifetime of molecular markers through a shift in gas-particle partitioning as well as a change in viscosity of the condensed phase. As a model case, this study examines the stability of levoglucosan, a key marker species of biomass burning, over a wide temperature range relevant to summertime and wintertime. Despite the importance of wood combustion for space heating in winter, the lifetime of levoglucosan in wintertime is not well understood. The model predicts that in low-temperature conditions, levoglucosan predominantly remains in the particle phase, and therefore its loss due to gas-phase oxidation reactions is significantly reduced. Furthermore, the movement of the levoglucosan from the bulk of the particle to the particle surface is reduced due to low diffusivity in the semi-solid state. The simplified model developed in this study reasonably reproduces upper and lower bounds of the lifetime of levoglucosan investigated in previous studies. The model results show that the levoglucosan depletion after seven days reduces significantly from ∼98% at 25 °C to marker (lifetime > 1 week) even at 60% relative humidity irrespective of the assumed fragility parameter D that controls estimated diffusivity. The model shows that lifetime of an organic molecular marker strongly depends on assumed D especially when a semi-volatile marker is in semi-solid organic aerosol.

  7. Comparative study of dense plasma state equations obtained from different models of average-atom

    International Nuclear Information System (INIS)

    Fromy, Patrice

    1991-01-01

    This research thesis addresses the influence of temperature and density effects on magnitudes such as pressure, energy, ionisation, and on energy levels of a body described according to the approximation of an electrically neutral isolated atomic sphere. Starting from the general formalism of the functional density, with some approximations, the author deduces the Thomas-Fermi, Thomas-Fermi-Dirac, and Thomas-Fermi-Dirac-Weizsaecker models, and an average-atom approximated quantum model. For each of these models, the author presents an explicit method of resolution, as well as the determination of different magnitudes taken into account in this study. For the different studied magnitudes, the author highlights effects due to the influence of temperature and of density, as well as variations due to the different models [fr

  8. Phase aided 3D imaging and modeling: dedicated systems and case studies

    Science.gov (United States)

    Yin, Yongkai; He, Dong; Liu, Zeyi; Liu, Xiaoli; Peng, Xiang

    2014-05-01

    Dedicated prototype systems for 3D imaging and modeling (3DIM) are presented. The 3D imaging systems are based on the principle of phase-aided active stereo, which have been developed in our laboratory over the past few years. The reported 3D imaging prototypes range from single 3D sensor to a kind of optical measurement network composed of multiple node 3D-sensors. To enable these 3D imaging systems, we briefly discuss the corresponding calibration techniques for both single sensor and multi-sensor optical measurement network, allowing good performance of the 3DIM prototype systems in terms of measurement accuracy and repeatability. Furthermore, two case studies including the generation of high quality color model of movable cultural heritage and photo booth from body scanning are presented to demonstrate our approach.

  9. A review of heat pump drying: Part 1 - systems, models and studies

    Energy Technology Data Exchange (ETDEWEB)

    Colak, Neslihan [Dept. of Food Engineering, Faculty of Engineering, Pamukkale Univ., 20070 Denizli (Turkey); Hepbasli, Arif [Dept. of Mechanical Engineering, Faculty of Engineering, Ege Univ., 35100 Bornova, Izmir (Turkey)

    2009-09-15

    The first heat pump dryer (HPD) patent applications were started in 1973, while recently, there has been a great interest in utilizing HPDs for drying fruits, vegetables and biological materials. This study deals with reviewing heat pump drying studies and consists of two parts. In the first part of this study, historical development of HPDs was briefly given first. Description of these systems was then presented. Finally, studies conducted on HPD were reviewed in terms of process efficiency modeling and progress of quality. (author)

  10. Beyond the standard Higgs at the LHC. Present constraints on little Higgs models and future prospects

    International Nuclear Information System (INIS)

    Tonini, Marco

    2014-11-01

    This thesis discusses the consistency of different Little Higgs models with the collected collider data as of the summer of 2013. Moreover, future prospects for possible discoveries and mass measurement methods of new physics signals at the foreseen LHC run II with increased center-of-mass energy are presented. Little Higgs models belong to a class of extensions of the Standard Higgs model, predicting a strong interaction regime at a compositeness scale Λ=4πf approximate global symmetry spontaneously broken at the scale f. A natural hierarchy between the compositeness and the electroweak scale is introduced by the Collective Symmetry Breaking mechanism: one-loop diagrams generating the Higgs mass term are forced to be at most logarithmically sensitive to Λ. A naturally light Higgs boson can thus be accommodated, consistently with a perturbative theory until a scale of order 10 TeV. We have probed the parameter space of three prominent examples of Little Higgs models, namely the Simplest Little Higgs model, the Littlest Higgs model, and the Littlest Higgs model with T-parity, against electroweak precision observables and the collected LHC data concerning both Higgs properties and direct searches for new particles, with √(s)=7,8 TeV and up to 25 fb -1 of integrated luminosity. Lower bounds on the scale f are set, within a certain degree of confidence level, which allow to draw conclusions on the ''naturalness'' of the different models. Optimisations of the existing direct searches setups, assuming a Little Higgs signal, as well as dedicated mass measurement methods designed for the foreseen LHC runs with √(s)=13,14 TeV are thoroughly discussed and proposed in this thesis. Special attention will be dedicated to final states including either a large or negligible fraction of missing transverse momentum. In particular, we will propose a dedicated collider search tailored for the discovery and mass measurement of a top partner, exploiting jet

  11. Study of system dynamics model and control of a high-power LED lighting luminaire

    International Nuclear Information System (INIS)

    Huang, B.-J.; Hsu, P.-C.; Wu, M.-S.; Tang, C.-W.

    2007-01-01

    The purpose of the present study is to design a current control system which is robust to the system dynamics uncertainty and the disturbance of ambient temperature to assure a stable optical output property of LED. The system dynamics model of the LED lighting system was first derived. A 96 W high-power LED luminaire was designed and built in the present study. The linearly perturbed system dynamics model for the LED luminaire is derived experimentally. The dynamics model of LED lighting system is of a multiple-input-multiple-output (MIMO) system with two inputs (applied voltage and ambient temperature) and two outputs (forward current and heat conducting body temperature). A step response test method was employed to the 96 W LED luminaire to identify the system dynamics model. It is found that the current model is just a constant gain (resistance) and the disturbance model is of first order, both changing with operating conditions (voltage and ambient temperature). A feedback control system using PI algorithm was designed using the results of the system dynamics model. The control system was implemented on a PIC microprocessor. Experimental results show that the control system can stably and accurately control the LED current to a constant value at the variation of ambient temperature up to 40 o C. The control system is shown to have a robust property with respect to the plant uncertainty and the ambient temperature disturbance

  12. Curriculum Studies in Brazil: Intellectual Histories, Present Circumstances. International and Development Education

    Science.gov (United States)

    Pinar, William F., Ed.

    2011-01-01

    This collection, comprised of chapters focused on the intellectual histories and present circumstances of curriculum studies in Brazil, is Pinar's summary of exchanges (occurring over a two-year period) between the authors and members of an International Panel (scholars working in Finland, South Africa, the United States). From these and the…

  13. A transfer function model of the BEPO reactor for control studies

    Energy Technology Data Exchange (ETDEWEB)

    Cummins, J D [Dynamics Group, Control and Instrumentation Division, Atomic Energy Establishment, Winfrith, Dorchester, Dorset (United Kingdom)

    1962-09-15

    A spatially independent (one point) transfer function model of the BEPO reactor is presented. Perturbations in control rod reactivity and coolant flow are considered and transfer functions deduced for variations about four steady states namely zero power, one sixth full power and one sixth full flow, one sixth full power and full flow and also full power and full flow. The transfer functions are presented in pole-zero form. The use of the transfer functions in verifying experimental frequency responses, in automatic control studies and in multi-variable non-interacting control design are briefly considered. (author)

  14. SVM and ANFIS Models for precipitaton Modeling (Case Study: GonbadKavouse

    Directory of Open Access Journals (Sweden)

    N. Zabet Pishkhani

    2016-10-01

    Full Text Available Introduction: In recent years, according to the intelligent models increased as new techniques and tools in hydrological processes such as precipitation forecasting. ANFIS model has good ability in train, construction and classification, and also has the advantage that allows the extraction of fuzzy rules from numerical information or knowledge. Another intelligent technique in recent years has been used in various areas is support vector machine (SVM. In this paper the ability of artificial intelligence methods including support vector machine (SVM and adaptive neuro fuzzy inference system (ANFIS were analyzed in monthly precipitation prediction. Materials and Methods: The study area was the city of Gonbad in Golestan Province. The city has a temperate climate in the southern highlands and southern plains, mountains and temperate humid, semi-arid and semi-arid in the north of Gorganroud river. In total, the city's climate is temperate and humid. In the present study, monthly precipitation was modeled in Gonbad using ANFIS and SVM and two different database structures were designed. The first structure: input layer consisted of mean temperature, relative humidity, pressure and wind speed at Gonbad station. The second structure: According to Pearson coefficient, the monthly precipitation data were used from four stations: Arazkoose, Bahalke, Tamar and Aqqala which had a higher correlation with Gonbad station precipitation. In this study precipitation data was used from 1995 to 2012. 80% data were used for model training and the remaining 20% of data for validation. SVM was developed from support vector machines in the 1990s by Vapnik. SVM has been widely recognized as a powerful tool to deal with function fitting problems. An Adaptive Neuro-Fuzzy Inference System (ANFIS refers, in general, to an adaptive network which performs the function of a fuzzy inference system. The most commonly used fuzzy system in ANFIS architectures is the Sugeno model

  15. APPLICATION OF AUGMENTED AND VIRTUAL REALITY IN RESIDENTIAL COMPLEX PRESENTATION, CASE STUDY: ENERGOPROJEKT SUNNYVILLE

    Directory of Open Access Journals (Sweden)

    PEJIC Petar

    2017-05-01

    Full Text Available The traditional method of residential complex project presentations involves the use of a printed poster or elaborate on which the building is presented by using of two-dimensional drawings and images. The main traditional approach problem is the presentation of three-dimensional space on two-dimensional paper. The main focus of this paper is the development of contemporary, mobile systems for residential complex presentations which will be presented on a case study of “Energoprojekt Sunnyville” using a method of virtual and augmented reality. This approach enables easier and better understanding of all types of architectural objects and urban complex, allowing the user intuitive spatial overview of architectural work.

  16. Modelling ESCOMPTE episodes with the CTM MOCAGE. Part 2 : sensitivity studies.

    Science.gov (United States)

    Dufour, A.; Amodei, M.; Brocheton, F.; Michou, M.; Peuch, V.-H.

    2003-04-01

    The multi-scale CTM MOCAGE has been applied to study pollution episodes documented during the ESCOMPTE field campain in June July 2001 in south eastern France (http://medias.obs-mip.fr/escompte). Several sensitivity studies have been performed on the basis of the 2nd IOP, covering 6 continuous days. The main objective of the present work is to investigate the question of chemical boundary conditions, as on the vertical than on the horizontal, for regional air quality simulations of several days. This issue, that often tended to be oversimplified (use of fixed continental climatology), raises increasing interest, particurlarly with the perspective of space-born tropospheric chemisry data assimilation in global model. In addition, we have examined how resolution refinements impact on the quality of the model outputs, at the surface and in altitude, against the observational database of dynamic and chemistry : resolution of the model by the way of the four nested models (from 2° to 0.01°), but also resolution of emission inventories (from 1° to 0.01°). Lastly, the impact of the refinement in the representation of chemistry has been assessed by using either detailed chemical schemes, such as RAM or SAPRC, or schemes used in global modelling, which just account for a limited amount of volatil hydrocarbon.

  17. Computer model for economic study of unbleached kraft paperboard production

    Science.gov (United States)

    Peter J. Ince

    1984-01-01

    Unbleached kraft paperboard is produced from wood fiber in an industrial papermaking process. A highly specific and detailed model of the process is presented. The model is also presented as a working computer program. A user of the computer program will provide data on physical parameters of the process and on prices of material inputs and outputs. The program is then...

  18. ED Triage Decision-Making With Mental Health Presentations: A "Think Aloud" Study.

    Science.gov (United States)

    Clarke, Diana E; Boyce-Gaudreau, Krystal; Sanderson, Ana; Baker, John A

    2015-11-01

    Triage is the process whereby persons presenting to the emergency department are quickly assessed by a nurse and their need for care and service is prioritized. Research examining the care of persons presenting to emergency departments with psychiatric and mental health problems has shown that triage has often been cited as the most problematic aspect of the encounter. Three questions guided this investigation: Where do the decisions that triage nurses make fall on the intuitive versus analytic dimensions of decision making for mental health presentations in the emergency department, and does this differ according to comfort or familiarity with the type of mental health/illness presentation? How do "decision aids" (i.e., structured triage scales) help in the decision-making process? To what extent do other factors, such as attitudes, influence triage nurses' decision making? Eleven triage nurses participating in this study were asked to talk out loud about the reasoning process they would engage in while triaging patients in 5 scenarios based on mental health presentations to the emergency department. Themes emerging from the data were tweaking the results (including the use of intuition and early judgments) to arrive at the desired triage score; consideration of the current ED environment; managing uncertainty and risk (including the consideration of physical reasons for presentation); and confidence in communicating with patients in distress and managing their own emotive reactions to the scenario. Findings support the preference for using the intuitive mode of decision making with only tacit reliance on the decision aid. Copyright © 2015 Emergency Nurses Association. Published by Elsevier Inc. All rights reserved.

  19. Using human brain imaging studies as a guide towards animal models of schizophrenia

    Science.gov (United States)

    BOLKAN, Scott S.; DE CARVALHO, Fernanda D.; KELLENDONK, Christoph

    2015-01-01

    Schizophrenia is a heterogeneous and poorly understood mental disorder that is presently defined solely by its behavioral symptoms. Advances in genetic, epidemiological and brain imaging techniques in the past half century, however, have significantly advanced our understanding of the underlying biology of the disorder. In spite of these advances clinical research remains limited in its power to establish the causal relationships that link etiology with pathophysiology and symptoms. In this context, animal models provide an important tool for causally testing hypotheses about biological processes postulated to be disrupted in the disorder. While animal models can exploit a variety of entry points towards the study of schizophrenia, here we describe an approach that seeks to closely approximate functional alterations observed with brain imaging techniques in patients. By modeling these intermediate pathophysiological alterations in animals, this approach offers an opportunity to (1) tightly link a single functional brain abnormality with its behavioral consequences, and (2) to determine whether a single pathophysiology can causally produce alterations in other brain areas that have been described in patients. In this review we first summarize a selection of well-replicated biological abnormalities described in the schizophrenia literature. We then provide examples of animal models that were studied in the context of patient imaging findings describing enhanced striatal dopamine D2 receptor function, alterations in thalamo-prefrontal circuit function, and metabolic hyperfunction of the hippocampus. Lastly, we discuss the implications of findings from these animal models for our present understanding of schizophrenia, and consider key unanswered questions for future research in animal models and human patients. PMID:26037801

  20. Studying psychosocial adaptation to end-stage renal disease: the proximal-distal model of health-related outcomes as a base model.

    Science.gov (United States)

    Chan, Ramony; Brooks, Robert; Erlich, Jonathan; Gallagher, Martin; Snelling, Paul; Chow, Josephine; Suranyi, Michael

    2011-05-01

    Studying psychosocial adaptation in end-stage renal disease (ESRD) is increasingly important, as it may explain the variability in health outcomes unaccounted for by clinical factors. The Brenner et al. proximal-distal model of health-related outcomes provides a theoretical foundation for understanding psychosocial adaptation and integrating health outcomes, clinical, and psychosocial factors (Brenner MH, Curbow B, Legro MW. The proximal-distal continuum of multiple health outcome measures: the case of cataract surgery. Med Care. 1995;33(4 Suppl):AS236-44). This study aims to empirically validate the proximal-distal model in the dialysis population and examine the impact of psychosocial factors on the model. A cross-sectional observational study was conducted with a sample of long-term dialysis patients (n=201). Eleven factors: quality of life (QoL), depression, positive affect, comorbidity, symptoms, physical functioning, disease accommodation, loss, self-efficacy, illness acceptance, and social support were measured by standardized psychometric scales. A three-month average of hemoglobin was used. Latent composite structural equation modeling was used to examine the models. The proximal-distal model with slight modification was supported by fit statistics [χ(2)=16.04, df=13, P=.25, root mean square error of approximation (RMSEA)=0.024], indicating that the impact of clinical factors on QoL is mediated through a range of functional and psychological factors, except for hemoglobin which impacts directly on QoL. The model with additional psychosocial factors was also supported by fit statistics (χ(2)=43.59, df=41, P=.36, RMSEA=0.018). These additional factors mainly impact on symptom status, psychological states, and QoL components of the model. The present study supported the proximal-distal model in the dialysis population and demonstrated the considerable impact of psychosocial factors on the model. The proximal-distal model plus psychosocial factors as a

  1. The effectiveness of emergency nurse practitioner service in the management of patients presenting to rural hospitals with chest pain: a multisite prospective longitudinal nested cohort study.

    Science.gov (United States)

    Roche, Tina E; Gardner, Glenn; Jack, Leanne

    2017-06-27

    Health reforms in service improvement have included the use of nurse practitioners. In rural emergency departments, nurse practitioners work to the full scope of their expanded role across all patient acuities including those presenting with undifferentiated chest pain. Currently, there is a paucity of evidence regarding the effectiveness of emergency nurse practitioner service in rural emergency departments. Inquiry into the safety and quality of the service, particularly regarding the management of complex conditions is a priority to ensure that this service improvement model meets health care needs of rural communities. This study used a prospective, longitudinal nested cohort study of rural emergency departments in Queensland, Australia. Sixty-one consecutive adult patients with chest pain who presented between November 2014 and February 2016 were recruited into the study cohort. A nested cohort of 41 participants with suspected or confirmed acute coronary syndrome were identified. The primary outcome was adherence to guidelines and diagnostic accuracy of electrocardiograph interpretation for the nested cohort. Secondary outcomes included service indicators of waiting times, diagnostic accuracy as measured by unplanned representation rates, satisfaction with care, quality-of-life, and functional status. Data were examined and compared for differences for participants managed by emergency nurse practitioners and those managed in the standard model of care. The median waiting time was 8.0 min (IQR 20) and length-of-stay was 100.0 min (IQR 64). Participants were 2.4 times more likely to have an unplanned representation if managed by the standard service model. The majority of participants (91.5%) were highly satisfied with the care that they received, which was maintained at 30-day follow-up measurement. In the evaluation of quality of life and functional status, summary scores for the SF-12 were comparable with previous studies. No differences were

  2. Dynamical study of a chaotic predator-prey model with an omnivore

    Science.gov (United States)

    Al-khedhairi, A.; Elsadany, A. A.; Elsonbaty, A.; Abdelwahab, A. G.

    2018-01-01

    In this paper, the dynamics and bifurcations of a three-species predator-prey model with an omnivore are further investigated. The food web considered in this work comprises prey, predator and a third species, which consumes the carcasses of the predator along with predation of the original prey. The conditions for existence, uniqueness and continuous dependence on initial conditions for the solution of the model are derived. Analytical and numerical bifurcation studies reveal that the system undergoes transcritical and Hopf bifurcations around its equilibrium points. Further, the Hopf bifurcation curves in the parameters' space along with codimension two bifurcations of equilibrium points and bifurcation of limit cycles that arise in the system are investigated. In particular, the occurrence of generalized Hopf, fold Hopf and Neimarck-Sacker bifurcations is unveiled and illustrates the rich dynamics of the model. Finally, bifurcation diagrams, phase portraits and Lyapunov exponents of the model are presented.

  3. The accident consequence model of the German safety study

    International Nuclear Information System (INIS)

    Huebschmann, W.

    1977-01-01

    The accident consequence model essentially describes a) the diffusion in the atmosphere and deposition on the soil of radioactive material released from the reactor into the atmosphere; b) the irradiation exposure and health consequences of persons affected. It is used to calculate c) the number of persons suffering from acute or late damage, taking into account possible counteractions such as relocation or evacuation, and d) the total risk to the population from the various types of accident. The model, the underlying parameters and assumptions are described. The bone marrow dose distribution is shown for the case of late overpressure containment failure, which is discussed in the paper of Heuser/Kotthoff, combined with four typical weather conditions. The probability distribution functions for acute mortality, late incidence of cancer and genetic damage are evaluated, assuming a characteristic population distribution. The aim of these calculations is first the presentation of some results of the consequence model as an example, in second the identification of problems, which need possibly in a second phase of study to be evaluated in more detail. (orig.) [de

  4. Present problems of the solar interior

    International Nuclear Information System (INIS)

    Roxburgh, I.W.

    1986-01-01

    The standard model of solar evolution is reviewed and a number of problems highlighted. A fundamental question is whether there is any mixing of matter in the central regions, since such mixing could radically alter the model of the present Sun and modify our understanding of the evolution of other stars. Standard models of solar evolution become unstable to /sup 3/He driven global oscillations at an age of 3 x 10/sup 8/ years and this may drive some mixing, even if this is not the case the finite amptitude limit of these oscillations is likely to produce modifications in the standard model. Convective overshooting at the bottom of the outer convective zone leads to an increased depth of this zone and small changes in the interior. It is pointed out that the young Sun had a /sup 12/C driven convective core whose extent and duration depends on the extend of overshooting. Such a core is likely to produce a magnetic field which will affect the internal dynamics. The internal rotation of the sun remains an enigma and absence of knowledge of any internal magnetic field makes it difficult to study the problem. Rotationally driven instabilities are ineffective in the central chemically inhomogeneous regions but may contribute to the inward diffusion of lithium from the convective zone. These and other problems are considered, but few solutions are proposed

  5. A conceptual sedimentological-geostatistical model of aquifer heterogeneity based on outcrop studies

    International Nuclear Information System (INIS)

    Davis, J.M.

    1994-01-01

    Three outcrop studies were conducted in deposits of different depositional environments. At each site, permeability measurements were obtained with an air-minipermeameter developed as part of this study. In addition, the geological units were mapped with either surveying, photographs, or both. Geostatistical analysis of the permeability data was performed to estimate the characteristics of the probability distribution function and the spatial correlation structure. The information obtained from the geological mapping was then compared with the results of the geostatistical analysis for any relationships that may exist. The main field site was located in the Albuquerque Basin of central New Mexico at an outcrop of the Pliocene-Pleistocene Sierra Ladrones Formation. The second study was conducted on the walls of waste pits in alluvial fan deposits at the Nevada Test Site. The third study was conducted on an outcrop of an eolian deposit (miocene) south of Socorro, New Mexico. The results of the three studies were then used to construct a conceptual model relating depositional environment to geostatistical models of heterogeneity. The model presented is largely qualitative but provides a basis for further hypothesis formulation and testing

  6. A conceptual sedimentological-geostatistical model of aquifer heterogeneity based on outcrop studies

    Energy Technology Data Exchange (ETDEWEB)

    Davis, J.M.

    1994-01-01

    Three outcrop studies were conducted in deposits of different depositional environments. At each site, permeability measurements were obtained with an air-minipermeameter developed as part of this study. In addition, the geological units were mapped with either surveying, photographs, or both. Geostatistical analysis of the permeability data was performed to estimate the characteristics of the probability distribution function and the spatial correlation structure. The information obtained from the geological mapping was then compared with the results of the geostatistical analysis for any relationships that may exist. The main field site was located in the Albuquerque Basin of central New Mexico at an outcrop of the Pliocene-Pleistocene Sierra Ladrones Formation. The second study was conducted on the walls of waste pits in alluvial fan deposits at the Nevada Test Site. The third study was conducted on an outcrop of an eolian deposit (miocene) south of Socorro, New Mexico. The results of the three studies were then used to construct a conceptual model relating depositional environment to geostatistical models of heterogeneity. The model presented is largely qualitative but provides a basis for further hypothesis formulation and testing.

  7. An Exploratory Study of the Role of Human Resource Management in Models of Employee Turnover

    Science.gov (United States)

    Ozolina-Ozola, Iveta

    2016-01-01

    The purpose of this paper is to present the study results of the human resource management role in the voluntary employee turnover models. The mixed methods design was applied. On the basis of the results of the search and evaluation of publications, the 16 models of employee turnover were selected. Applying the method of content analysis, the…

  8. Use of Invasion Percolation Models To Study the Secondary Migration of Oil and Related Problems

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, G.

    1997-12-31

    This thesis studies simulations of the slow displacement of a wetting fluid by a non-wetting fluid in porous media and in a single fracture. The simulations are based on the invasion percolation model. New modified versions of the model are presented that simulate migration, fragmentation and coalescence processes of the clusters of non-wetting fluid. The resulting displacement patterns are characterized by scaling laws. In particular, simulations of the secondary migration of oil through porous homogeneous rock are discussed. Fractured rocks are extreme cases of inhomogeneous porous media. Simulations of the slow displacement of a wetting fluid by a non-wetting fluid in a single fracture using the standard invasion model are presented. There is a discussion of a scenario in which a cluster of non-wetting fluid migrates through a porous medium that was saturated with a wetting fluid. The migration is driven by continuously driven buoyancy forces. Both experiments and simulations are described. The same scenario is also studied theoretically and by simulations using a simplified percolation model of fluid migration in one dimension. The migration model in two dimensions, with constant buoyancy forces, is also discussed. Simulations of fluid migration, such as the secondary migration of oil, in two- and three-dimensional media are examined, the media having multi-affine properties rather than being homogeneous. Slow immiscible displacement processes in single fractures are studied using fractal geometries to model single fractures. 167 refs., 123 figs.

  9. Example of emergency response model evaluation of studies using the Mathew/Adpic models

    International Nuclear Information System (INIS)

    Dickerson, M.H.; Lange, R.

    1986-04-01

    This report summarizes model evaluation studies conducted for the MATHEW/ADPIC transport and diffusion models during the past ten years. These models support the US Department of Energy Atmospheric Release Advisory Capability, an emergency response service for atmospheric releases of nuclear material. Field studies involving tracer releases used in these studies cover a broad range of meteorology, terrain and tracer release heights, the three most important aspects of estimating air concentration values resulting from airborne releases of toxic material. Results of these studies show that these models can estimate air concentration values within a factor of 2 20% to 50% of the time and a factor of 5 40% to 80% of the time. As the meterology and terrain become more complex and the release height of the tracer is increased, the accuracy of the model calculations degrades. This band of uncertainty appears to correctly represent the capability of these models at this time. A method for estimating angular uncertainty in the model calculations is described and used to suggest alternative methods for evaluating emergency response models

  10. Task Equivalence for Model and Human-Observer Comparisons in SPECT Localization Studies

    Science.gov (United States)

    Sen, Anando; Kalantari, Faraz; Gifford, Howard C.

    2016-06-01

    While mathematical model observers are intended for efficient assessment of medical imaging systems, their findings should be relevant for human observers as the primary clinical end users. We have investigated whether pursuing equivalence between the model and human-observer tasks can help ensure this goal. A localization receiver operating characteristic (LROC) study tested prostate lesion detection in simulated In-111 SPECT imaging with anthropomorphic phantoms. The test images were 2D slices extracted from reconstructed volumes. The iterative ordered sets expectation-maximization (OSEM) reconstruction algorithm was used with Gaussian postsmoothing. Variations in the number of iterations and the level of postfiltering defined the test strategies in the study. Human-observer performance was compared with that of a visual-search (VS) observer, a scanning channelized Hotelling observer, and a scanning channelized nonprewhitening (CNPW) observer. These model observers were applied with precise information about the target regions of interest (ROIs). ROI knowledge was a study variable for the human observers. In one study format, the humans read the SPECT image alone. With a dual-modality format, the SPECT image was presented alongside an anatomical image slice extracted from the density map of the phantom. Performance was scored by area under the LROC curve. The human observers performed significantly better with the dual-modality format, and correlation with the model observers was also improved. Given the human-observer data from the SPECT study format, the Pearson correlation coefficients for the model observers were 0.58 (VS), -0.12 (CH), and -0.23 (CNPW). The respective coefficients based on the human-observer data from the dual-modality study were 0.72, 0.27, and -0.11. These results point towards the continued development of the VS observer for enhancing task equivalence in model-observer studies.

  11. How does spatial study design influence density estimates from spatial capture-recapture models?

    Directory of Open Access Journals (Sweden)

    Rahel Sollmann

    Full Text Available When estimating population density from data collected on non-invasive detector arrays, recently developed spatial capture-recapture (SCR models present an advance over non-spatial models by accounting for individual movement. While these models should be more robust to changes in trapping designs, they have not been well tested. Here we investigate how the spatial arrangement and size of the trapping array influence parameter estimates for SCR models. We analysed black bear data collected with 123 hair snares with an SCR model accounting for differences in detection and movement between sexes and across the trapping occasions. To see how the size of the trap array and trap dispersion influence parameter estimates, we repeated analysis for data from subsets of traps: 50% chosen at random, 50% in the centre of the array and 20% in the South of the array. Additionally, we simulated and analysed data under a suite of trap designs and home range sizes. In the black bear study, we found that results were similar across trap arrays, except when only 20% of the array was used. Black bear density was approximately 10 individuals per 100 km(2. Our simulation study showed that SCR models performed well as long as the extent of the trap array was similar to or larger than the extent of individual movement during the study period, and movement was at least half the distance between traps. SCR models performed well across a range of spatial trap setups and animal movements. Contrary to non-spatial capture-recapture models, they do not require the trapping grid to cover an area several times the average home range of the studied species. This renders SCR models more appropriate for the study of wide-ranging mammals and more flexible to design studies targeting multiple species.

  12. Mathematical modelling with case studies using Maple and Matlab

    CERN Document Server

    Barnes, B

    2014-01-01

    Introduction to Mathematical ModelingMathematical models An overview of the book Some modeling approaches Modeling for decision makingCompartmental Models Introduction Exponential decay and radioactivity Case study: detecting art forgeries Case study: Pacific rats colonize New Zealand Lake pollution models Case study: Lake Burley Griffin Drug assimilation into the blood Case study: dull, dizzy, or dead? Cascades of compartments First-order linear DEs Equilibrium points and stability Case study: money, money, money makes the world go aroundModels of Single PopulationsExponential growth Density-

  13. Fitting non-gaussian Models to Financial data: An Empirical Study

    Directory of Open Access Journals (Sweden)

    Pablo Olivares

    2011-04-01

    Full Text Available In this paper are presented some experiences about the modeling of financial data by three classes of models as alternative to Gaussian Linear models. Dynamic Volatility, Stable L'evy and Diffusion with Jumps models are considered. The techniques are illustrated with some examples of financial series on currency, futures and indexes.

  14. Recovery as a model of care? Insights from an Australian case study.

    Science.gov (United States)

    Hungerford, Catherine

    2014-03-01

    The terms "model of health care," "service model." and "nursing model of practice" are often used interchangeably in practice, policy, and research, despite differences in definitions. This article considers these terms in the context of consumer-centred recovery and its implementation into a publicly-funded health service organization in Australia. Findings of a case study analysis are used to inform the discussion, which considers the diverse models of health care employed by health professionals; together with the implications for organizations worldwide that are responsible for operationalizing recovery approaches to health care. As part of the discussion, it is suggested that the advent of recovery-oriented services, rather than recovery models of health care, presents challenges for the evaluation of the outcomes of these services. At the same time, this situation provides opportunities for mental health nurses to lead the way, by developing rigorous models of practice that support consumers who have acute, chronic, or severe mental illness on their recovery journey; and generate positive, measureable outcomes.

  15. A comprehensive approach to dark matter studies: exploration of simplified top-philic models

    Energy Technology Data Exchange (ETDEWEB)

    Arina, Chiara; Backović, Mihailo [Centre for Cosmology, Particle Physics and Phenomenology (CP3),Université catholique de Louvain, Chemin du Cyclotron 2, B-1348 Louvain-la-Neuve (Belgium); Conte, Eric [Groupe de Recherche de Physique des Hautes Énergies (GRPHE), Université de Haute-Alsace,IUT Colmar, F-68008 Colmar Cedex (France); Fuks, Benjamin [Sorbonne Universités, UPMC University Paris 06, UMR 7589, LPTHE, F-75005, Paris (France); CNRS, UMR 7589, LPTHE, F-75005, Paris (France); Guo, Jun [State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics,Chinese Academy of Sciences, Beijing 100190 (China); Institut Pluridisciplinaire Hubert Curien/Département Recherches Subatomiques,Université de Strasbourg/CNRS-IN2P3, F-67037 Strasbourg (France); Heisig, Jan [Institute for Theoretical Particle Physics and Cosmology, RWTH Aachen University,Sommerfeldstr. 16, D-52056 Aachen (Germany); Hespel, Benoît [Centre for Cosmology, Particle Physics and Phenomenology (CP3),Université catholique de Louvain, Chemin du Cyclotron 2, B-1348 Louvain-la-Neuve (Belgium); Krämer, Michael [Institute for Theoretical Particle Physics and Cosmology, RWTH Aachen University,Sommerfeldstr. 16, D-52056 Aachen (Germany); Maltoni, Fabio; Martini, Antony [Centre for Cosmology, Particle Physics and Phenomenology (CP3),Université catholique de Louvain, Chemin du Cyclotron 2, B-1348 Louvain-la-Neuve (Belgium); Mawatari, Kentarou [Laboratoire de Physique Subatomique et de Cosmologie, Université Grenoble-Alpes,CNRS/IN2P3, 53 Avenue des Martyrs, F-38026 Grenoble (France); Theoretische Natuurkunde and IIHE/ELEM, Vrije Universiteit Brussel andInternational Solvay Institutes, Pleinlaan 2, B-1050 Brussels (Belgium); Pellen, Mathieu [Universität Würzburg, Institut für Theoretische Physik und Astrophysik,Emil-Hilb-Weg 22, 97074 Würzburg (Germany); Vryonidou, Eleni [Centre for Cosmology, Particle Physics and Phenomenology (CP3),Université catholique de Louvain, Chemin du Cyclotron 2, B-1348 Louvain-la-Neuve (Belgium)

    2016-11-21

    Studies of dark matter lie at the interface of collider physics, astrophysics and cosmology. Constraining models featuring dark matter candidates entails the capability to provide accurate predictions for large sets of observables and compare them to a wide spectrum of data. We present a framework which, starting from a model Lagrangian, allows one to consistently and systematically make predictions, as well as to confront those predictions with a multitude of experimental results. As an application, we consider a class of simplified dark matter models where a scalar mediator couples only to the top quark and a fermionic dark sector (i.e. the simplified top-philic dark matter model). We study in detail the complementarity of relic density, direct/indirect detection and collider searches in constraining the multi-dimensional model parameter space, and efficiently identify regions where individual approaches to dark matter detection provide the most stringent bounds. In the context of collider studies of dark matter, we point out the complementarity of LHC searches in probing different regions of the model parameter space with final states involving top quarks, photons, jets and/or missing energy. Our study of dark matter production at the LHC goes beyond the tree-level approximation and we show examples of how higher-order corrections to dark matter production processes can affect the interpretation of the experimental results.

  16. Long-range transport and global fractionation of POPs: insights from multimedia modeling studies

    International Nuclear Information System (INIS)

    Scheringer, M.; Salzmann, M.; Stroebe, M.; Wegmann, F.; Fenner, K.; Hungerbuehler, K.

    2004-01-01

    The long-range transport of persistent organic pollutants (POPs) is investigated with two multimedia box models of the global system. ChemRange is a purely evaluative, one-dimensional steady-state (level III) model; CliMoChem is a two-dimensional model with different temperatures, land/water ratios and vegetation types in different latitudinal zones. Model results are presented for three case studies: (i) the effect of atmospheric aerosol particles on the long-range transport of POPs, (ii) the effect of oceanic deposition on the long-range transport of different PCB congeners, (iii) the global fractionation of different PCB congeners. The model results for these case studies show: (i) the low atmospheric half-lives estimated for several organochlorine pesticides are likely to be inconsistent with the observed long-range transport of these compounds; (ii) export to the deep sea reduces the potential for long-range transport of highly hydrophobic compounds (but does not remove these chemicals from the biosphere); (iii) there are different meanings of the term global fractionation that refer to different aspects of the fractionation process and need to be distinguished. The case-study results further indicate that the influences of varying environmental conditions on the physicochemical properties and the degradation rate constants of POPs need to be determined. - Multimedia box models are applied to case studies of the behavior of POPs

  17. ECRIS 2010 - Proceedings and Presentations

    International Nuclear Information System (INIS)

    2012-01-01

    The workshop focussed on the latest developments in performance, modeling and applications of ECR ion sources along with the associated physics and technologies, including plasma physics, beam optics, beam diagnostics, magnet technology.... The presentations were organized around 8 topics: 1) status of ECRIS operation, 2) new developments, 3) ion beams and low energy beam transport (LEBT), 4) pulsed operation, 5) applications, and 6) plasma and beam investigations. Most papers are accompanied with the slides of their presentation

  18. Climate Past and Present: A Study on Glaciology of Himalayas in India

    Science.gov (United States)

    Shanmuganandan, S.

    2003-04-01

    Glaciers are moving bodies of ice and snow, which are normally present above the snow line. Glaciers and ice sheets are hundreds to more than one thousand meters thick and change significantly only over decades. On these longer time scales they can influence atmospheric circulation and global sea levels. Glaciers play an important role in maintaining ecosystem stability as they act as buffers and regulate the runoff water supply from high mountains to the plains during both dry and wet spells. The present study is an attempt to analyze the Climate of the Past and Present of the Himalayas with reference to study the glaciology. The study also attempted to use the remote sensed data to explore the past and present situation of glaciology of the Himalayas. Since mountain glaciology of Himalayas played a vital role and stand as an example to explore the possibility of the climate change that occurred from the past to the present and also to determine the status in the future. The Study was based on the secondary and primary data collected from available sources and also collected from various published records to document the evidences for the same. It was observed that the Himalayan glaciers account for about 70% of the world’s non-polar glaciers and affect the lives of millions of people in several countries: China, India, Pakistan, Afghanistan, Nepal and Bangladesh. Their runoff feeds two of the oldest rivers in the world, the Indus and the Ganges, whose tributaries carry precious water for 500 million people on the northern Indian plains. Most of the glaciers in the Himalayas are of a summer-accumulation type, that is major accumulation and ablation take place simultaneously during summer (Fujita et. al, 1997). The glaciers of the Himalayas include some of the longest outside the Polar Regions and reached their largest extent during the end of the last ice age (more than 20,000 years ago). The evidence of these large ice masses can be seen in 'U' shaped valleys

  19. Methodology study for documentation and 3D modelling of blast induced fractures

    International Nuclear Information System (INIS)

    Olsson, Mats; Markstroem, Ingemar; Pettersson, Anders

    2008-05-01

    The purpose of this activity as part of the Zuse project was to test whether it is possible to produce a 3D model of blast induced fractures around a tunnel and also to find a methodology suitable for large scale studies. The purpose of the studies is to increase the understanding of the excavation damage zone (EDZ) and the possibility of an existing continuous EDZ along the tunnel. For the investigation, an old test area in the Q tunnel at the Aespoe Hard Rock Laboratory was selected, where slabs were excavated in 2003 to investigate the fracture pattern around the contour holes of a blasted tunnel. The rock walls of the excavated niche were studied and documented in the tunnel, while the excavated rock slabs were documented above ground. The work flow included photo documentation of both sides. The photos taken in the tunnel had to be rectified and then the fractures were vectorized automatically in a vectorization program, generating AutoCad DWG-files as output. The vectorized fractures were then moved to MicroStation/RVS where they were interpreted and connected into continuous line strings. The digitized slab and rock sides were then moved to the correct position in 3D space. Finally, a 3D model was made in RVS where the fracture traces were connected into undulating fracture planes in 3D. The conclusion is that it is possible to build a 3D model; the model is presented in Chapter 3.5. However, the age and condition of the slabs may have influenced the quality of the model in this study. The quality of a model that can be built in a future investigation, should be much better if the surveys are adapted to the investigation at hand and the slabs and rock sides are fresh and in better condition. The validity of a model depends on the density of the investigation data. There is also always a risk of over interpretation; the wish to identify a fracture from one section to the next can lead to an interpretation of the fractures as more persistent than they actually

  20. Methodology study for documentation and 3D modelling of blast induced fractures

    Energy Technology Data Exchange (ETDEWEB)

    Olsson, Mats (Swebrec - Swedish Blasting Research Centre, Luleaa (Sweden)); Markstroem, Ingemar; Pettersson, Anders (Golder Associates (Sweden))

    2008-05-15

    The purpose of this activity as part of the Zuse project was to test whether it is possible to produce a 3D model of blast induced fractures around a tunnel and also to find a methodology suitable for large scale studies. The purpose of the studies is to increase the understanding of the excavation damage zone (EDZ) and the possibility of an existing continuous EDZ along the tunnel. For the investigation, an old test area in the Q tunnel at the Aespoe Hard Rock Laboratory was selected, where slabs were excavated in 2003 to investigate the fracture pattern around the contour holes of a blasted tunnel. The rock walls of the excavated niche were studied and documented in the tunnel, while the excavated rock slabs were documented above ground. The work flow included photo documentation of both sides. The photos taken in the tunnel had to be rectified and then the fractures were vectorized automatically in a vectorization program, generating AutoCad DWG-files as output. The vectorized fractures were then moved to MicroStation/RVS where they were interpreted and connected into continuous line strings. The digitized slab and rock sides were then moved to the correct position in 3D space. Finally, a 3D model was made in RVS where the fracture traces were connected into undulating fracture planes in 3D. The conclusion is that it is possible to build a 3D model; the model is presented in Chapter 3.5. However, the age and condition of the slabs may have influenced the quality of the model in this study. The quality of a model that can be built in a future investigation, should be much better if the surveys are adapted to the investigation at hand and the slabs and rock sides are fresh and in better condition. The validity of a model depends on the density of the investigation data. There is also always a risk of over interpretation; the wish to identify a fracture from one section to the next can lead to an interpretation of the fractures as more persistent than they actually

  1. Study of the critical behavior of the O(N) linear and nonlinear sigma models

    International Nuclear Information System (INIS)

    Graziani, F.R.

    1983-01-01

    A study of the large N behavior of both the O(N) linear and nonlinear sigma models is presented. The purpose is to investigate the relationship between the disordered (ordered) phase of the linear and nonlinear sigma models. Utilizing operator product expansions and stability analyses, it is shown that for 2 - (lambda/sub R/(M) is the dimensionless renormalized quartic coupling and lambda* is the IR fixed point) limit of the linear sigma model which yields the nonlinear sigma model. It is also shown that stable large N linear sigma models with lambda 0) and nonlinear models are trivial. This result (i.e., triviality) is well known but only for one and two component models. Interestingly enough, the lambda< d = 4 linear sigma model remains nontrivial and tachyonic free

  2. A Study of Synchronous Machine Model Implementations in Matlab/Simulink Simulations for New and Renewable Energy Systems

    DEFF Research Database (Denmark)

    Chen, Zhe; Blaabjerg, Frede; Iov, Florin

    2005-01-01

    A direct phase model of synchronous machines implemented in MA TLAB/SIMULINK is presented. The effects of the machine saturation have been included. Simulation studies are performed under various conditions. It has been demonstrated that the MATLAB/SIMULINK is an effective tool to study the compl...... synchronous machine and the implemented model could be used for studies of various applications of synchronous machines including in renewable and DG generation systems....

  3. Study of ATES thermal behavior using a steady flow model

    Science.gov (United States)

    Doughty, C.; Hellstroem, G.; Tsang, C. F.; Claesson, J.

    1981-01-01

    The thermal behavior of a single well aquifer thermal energy storage system in which buoyancy flow is neglected is studied. A dimensionless formulation of the energy transport equations for the aquifer system is presented, and the key dimensionless parameters are discussed. A simple numerical model is used to generate graphs showing the thermal behavior of the system as a function of these parameters. Some comparisons with field experiments are given to illustrate the use of the dimensionless groups and graphs.

  4. Meso-scale effects of tropical deforestation in Amazonia: preparatory LBA modelling studies

    Directory of Open Access Journals (Sweden)

    A. J. Dolman

    1999-08-01

    Full Text Available As part of the preparation for the Large-Scale Biosphere Atmosphere Experiment in Amazonia, a meso-scale modelling study was executed to highlight deficiencies in the current understanding of land surface atmosphere interaction at local to sub-continental scales in the dry season. Meso-scale models were run in 1-D and 3-D mode for the area of Rondonia State, Brazil. The important conclusions are that without calibration it is difficult to model the energy partitioning of pasture; modelling that of forest is easier due to the absence of a strong moisture deficit signal. The simulation of the boundary layer above forest is good, above deforested areas (pasture poor. The models' underestimate of the temperature of the boundary layer is likely to be caused by the neglect of the radiative effects of aerosols caused by biomass burning, but other factors such as lack of sufficient entrainment in the model at the mixed layer top may also contribute. The Andes generate patterns of subsidence and gravity waves, the effects of which are felt far into the Rondonian area The results show that the picture presented by GCM modelling studies may need to be balanced by an increased understanding of what happens at the meso-scale. The results are used to identify key measurements for the LBA atmospheric meso-scale campaign needed to improve the model simulations. Similar modelling studies are proposed for the wet season in Rondonia, when convection plays a major role.Key words. Atmospheric composition and structure (aerosols and particles; biosphere-atmosphere interactions · Meterology and atmospheric dynamics (mesoscale meterology

  5. Meso-scale effects of tropical deforestation in Amazonia: preparatory LBA modelling studies

    Directory of Open Access Journals (Sweden)

    A. J. Dolman

    Full Text Available As part of the preparation for the Large-Scale Biosphere Atmosphere Experiment in Amazonia, a meso-scale modelling study was executed to highlight deficiencies in the current understanding of land surface atmosphere interaction at local to sub-continental scales in the dry season. Meso-scale models were run in 1-D and 3-D mode for the area of Rondonia State, Brazil. The important conclusions are that without calibration it is difficult to model the energy partitioning of pasture; modelling that of forest is easier due to the absence of a strong moisture deficit signal. The simulation of the boundary layer above forest is good, above deforested areas (pasture poor. The models' underestimate of the temperature of the boundary layer is likely to be caused by the neglect of the radiative effects of aerosols caused by biomass burning, but other factors such as lack of sufficient entrainment in the model at the mixed layer top may also contribute. The Andes generate patterns of subsidence and gravity waves, the effects of which are felt far into the Rondonian area The results show that the picture presented by GCM modelling studies may need to be balanced by an increased understanding of what happens at the meso-scale. The results are used to identify key measurements for the LBA atmospheric meso-scale campaign needed to improve the model simulations. Similar modelling studies are proposed for the wet season in Rondonia, when convection plays a major role.

    Key words. Atmospheric composition and structure (aerosols and particles; biosphere-atmosphere interactions · Meterology and atmospheric dynamics (mesoscale meterology

  6. Myocardial Contractile Dysfunction is Present Without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and is Prevented after Claudin-5 Virotherapy

    Directory of Open Access Journals (Sweden)

    Nima Milani-Nejad

    2016-12-01

    Full Text Available AbstractMutations in several members of the dystrophin glycoprotein complex lead to skeletal and cardiomyopathies. Cardiac care for these muscular dystrophies consists of management of symptoms with standard heart medications after detection of reduced whole heart function. Recent evidence from both Duchenne muscular dystrophy patients and animal models suggests that myocardial dysfunction is present before myocardial damage or deficiencies in whole heart function, and that treatment prior to heart failure symptoms may be beneficial. To determine whether this same early myocardial dysfunction is present in other muscular dystrophy cardiomyopathies, we conducted a physiological assessment of cardiac function at the tissue level in the δ-sarcoglycan null mouse model (Sgcd-/- of Limb-girdle muscular dystrophy type 2F. Baseline cardiac contractile force measurements using ex vivo intact linear muscle preparations, were severely depressed in these mice without the presence of histopathology. Virotherapy with claudin-5 prevents the onset of cardiomyopathy in another muscular dystrophy model. After virotherapy with claudin-5, the cardiac contractile force deficits in Sgcd-/- mice are no longer significant. These studies suggest that screening Limb-girdle muscular dystrophy patients using methods that detect earlier functional changes may provide a longer therapeutic window for cardiac care.

  7. Betatron stochastic cooling in the Debuncher: Present and future

    International Nuclear Information System (INIS)

    Visnjic, V.

    1993-07-01

    A detailed study of the betatron stochastic cooling in the Debuncher is presented. First, a complete theoretical model including the emittance-dependent signal-to-noise ratio as well as time-dependent mixing is constructed. The emittance measurements in the Debuncher are described and it is shown that the model is in excellent agreement with the experimental data. The idea of gain shaping is proposed and it is shown that the gain shaping would improve the cooling of the beam. Several proposals for future improvements are studied and appraised, in particular, gain shaping, ramped η, and cryogenic and ''smart'' pickups and kickers. Finally, the demands which the Main Injector will impose on the Debuncher are analyzed and a design of the betatron stochastic cooling system for the Main Injector era is outlined

  8. Unmatched Case-Control Study on Late Presentation of HIV Infection in Santiago, Cape Verde (2004-2011).

    Science.gov (United States)

    Moreira, António L; Fronteira, Inês; Augusto, Gonçalo Figueiredo; Martins, Maria Rosario O

    2016-03-15

    Access to free antiretroviral therapy (ART) in Sub-Saharan Africa has been steadily increasing over the past decade. However, the success of large-scale ART programmes depends on timely diagnosis and early initiation of HIV care. This study characterizes late presenters to HIV care in Santiago (Cape Verde) between 2004 and 2011, and identifies factors associated with late presentation for care. We defined late presentation as persons presenting to HIV care with a CD4 count below 350 cells/mm³. An unmatched case-control study was conducted using socio-demographic and behavioural data of 368 individuals (191 cases and 177 controls) collected through an interviewer-administered questionnaire, comparing HIV patients late and early presented to care. Logistic regression was performed to estimate odds ratio and 95% confidence intervals. Results show that 51.9% were late presenters for HIV. No differences were found in gender distribution, marital status, or access to health services between cases and controls. Participants who undertook an HIV test by doctor indication were more likely to present late compared with those who tested for HIV by their own initiative. Also, individuals taking less time to initiate ART are more likely to present late. This study highlights the need to better understand reasons for late presentation to HIV care in Cape Verde. People in older age groups should be targeted in future approaches focused on late presenters to HIV care.

  9. Towards an ethological animal model of depression? A study on horses.

    Directory of Open Access Journals (Sweden)

    Carole Fureix

    Full Text Available Recent reviews question current animal models of depression and emphasise the need for ethological models of mood disorders based on animals living under natural conditions. Domestic horses encounter chronic stress, including potential stress at work, which can induce behavioural disorders (e.g. "apathy". Our pioneering study evaluated the potential of domestic horses in their usual environment to become an ethological model of depression by testing this models' face validity (i.e. behavioural similarity with descriptions of human depressive states.We observed the spontaneous behaviour of 59 working horses in their home environment, focusing on immobility bouts of apparent unresponsiveness when horses displayed an atypical posture (termed withdrawn hereafter, evaluated their responsiveness to their environment and their anxiety levels, and analysed cortisol levels. Twenty-four percent of the horses presented the withdrawn posture, also characterized by gaze, head and ears fixity, a profile that suggests a spontaneous expression of "behavioural despair". When compared with control "non-withdrawn" horses from the same stable, withdrawn horses appeared more indifferent to environmental stimuli in their home environment but reacted more emotionally in more challenging situations. They exhibited lower plasma cortisol levels. Withdrawn horses all belonged to the same breed and females were over-represented.Horse might be a useful potential candidate for an animal model of depression. Face validity of this model appeared good, and potential genetic input and high prevalence of these disorders in females add to the convergence. At a time when current animal models of depression are questioned and the need for novel models is expressed, this study suggests that novel models and biomarkers could emerge from ethological approaches in home environments.

  10. Applications of the FIV Model to Study HIV Pathogenesis

    Directory of Open Access Journals (Sweden)

    Craig Miller

    2018-04-01

    Full Text Available Feline immunodeficiency virus (FIV is a naturally-occurring retrovirus that infects domestic and non-domestic feline species, producing progressive immune depletion that results in an acquired immunodeficiency syndrome (AIDS. Much has been learned about FIV since it was first described in 1987, particularly in regard to its application as a model to study the closely related lentivirus, human immunodeficiency virus (HIV. In particular, FIV and HIV share remarkable structure and sequence organization, utilize parallel modes of receptor-mediated entry, and result in a similar spectrum of immunodeficiency-related diseases due to analogous modes of immune dysfunction. This review summarizes current knowledge of FIV infection kinetics and the mechanisms of immune dysfunction in relation to opportunistic disease, specifically in regard to studying HIV pathogenesis. Furthermore, we present data that highlight changes in the oral microbiota and oral immune system during FIV infection, and outline the potential for the feline model of oral AIDS manifestations to elucidate pathogenic mechanisms of HIV-induced oral disease. Finally, we discuss advances in molecular biology, vaccine development, neurologic dysfunction, and the ability to apply pharmacologic interventions and sophisticated imaging technologies to study experimental and naturally occurring FIV, which provide an excellent, but often overlooked, resource for advancing therapies and the management of HIV/AIDS.

  11. A systematic review and checklist presenting the main challenges for health economic modeling in personalized medicine : towards implementing patient-level models

    NARCIS (Netherlands)

    Degeling, Koen; Koffijberg, Hendrik; IJzerman, Maarten Joost

    2017-01-01

    Introduction: The ongoing development of genomic medicine and the use of molecular and imaging markers in personalized medicine (PM) has arguably challenged the field of health economic modeling (HEM). This study aims to provide detailed insights into the current status of HEM in PM, in order to

  12. Preference learning for cognitive modeling: a case study on entertainment preferences

    DEFF Research Database (Denmark)

    Yannakakis, Georgios; Maragoudakis, Manolis; Hallam, John

    2009-01-01

    Learning from preferences, which provide means for expressing a subject's desires, constitutes an important topic in machine learning research. This paper presents a comparative study of four alternative instance preference learning algorithms (both linear and nonlinear). The case study...... investigated is to learn to predict the expressed entertainment preferences of children when playing physical games built on their personalized playing features (entertainment modeling). Two of the approaches are derived from the literature--the large-margin algorithm (LMA) and preference learning...... with Gaussian processes--while the remaining two are custom-designed approaches for the problem under investigation: meta-LMA and neuroevolution. Preference learning techniques are combined with feature set selection methods permitting the construction of effective preference models, given suitable individual...

  13. ADMS-AIRPORT: MODEL INTER-COMPARISIONS AND MODEL VALIDATION

    OpenAIRE

    Carruthers, David; McHugh, Christine; Church, Stephanie; Jackson, Mark; Williams, Matt; Price, Catheryn; Lad, Chetan

    2008-01-01

    Abstract: The functionality of ADMS-Airport and details of its use in the Model Inter-comparison Study of the Project for the Sustainable Development of Heathrow Airport (PSDH) have previously been presented, Carruthers et al (2007). A distinguishing feature is the treatment of jet engine emissions as moving jet sources rather than averaging these emissions into volume sources as is the case in some other models. In this presentation two further studies are presented which each contribu...

  14. Novel Threadlike Structures May Be Present on the Large Animal Organ Surface: Evidence in Swine Model

    Directory of Open Access Journals (Sweden)

    Kyoung-Hee Bae

    2013-01-01

    Full Text Available Background. The types of embryonic development probably provoke different paths of novel threadlike structure (NTS development. The authors hypothesized that NTS may be easily observed on the surface of swine intestines by using trypan blue staining method and visualization under an optical microscope. Methods. General anesthesia was administered to 2 Yorkshire pigs. The abdominal walls of the pigs were carefully dissected along the medial alba. NTSs were identified on organ surfaces under a stereoscopic microscope after trypan blue staining. Isolated NTS specimens obtained from the large intestine were subjected to 4′,6-diamidino-2-phenylindole (DAPI staining and observed using the polarized light microscopy to confirm whether the obtained structure fits the definition of NTS. Results. We found elastic, semitransparent threadlike structures (forming a network structure that had a milky-white color in situ and in vivo in swine large intestines. The samples showed distinct extinction of polarized light at every 90 degrees, and nucleus was shown to be rod shaped by DAPI staining, indicating that they meet the criteria of NTS. Conclusion. We used a swine model to demonstrate that NTS may be present on large animal organ surfaces. Our results may permit similar studies by using human specimens.

  15. Stochastic Optimization Model to STudy the Operational Impacts of High Wind Penetrations in Ireland

    DEFF Research Database (Denmark)

    Meibom, Peter; Barth, R.; Hasche, B.

    2011-01-01

    A stochastic mixed integer linear optimization scheduling model minimizing system operation costs and treating load and wind power production as stochastic inputs is presented. The schedules are updated in a rolling manner as more up-to-date information becomes available. This is a fundamental...... change relative to day-ahead unit commitment approaches. The need for reserves dependent on forecast horizon and share of wind power has been estimated with a statistical model combining load and wind power forecast errors with scenarios of forced outages. The model is used to study operational impacts...

  16. Modeling the Activities of Scientists: Prospective Science Teachers' Poster Presentations in An STS Course

    Science.gov (United States)

    Dogan, Alev; Kaya, Osman Nafiz; Kilic, Ziya; Kilic, Esma; Aydogdu, Mustafa

    2004-01-01

    In this study, prospective science teachers' (PSTs) views about their poster presentations were investigated. These posters were developed through PSTs' online and library research and scientific mini-symposiums in chemistry related topics in the framework of science, technology and society course (STS). During the first four weeks of STS course,…

  17. Dressed to Present: Ratings of Classroom Presentations Vary with Attire

    Science.gov (United States)

    Gurung, Regan A. R.; Kempen, Laura; Klemm, Kayla; Senn, Rebecca; Wysocki, Rosie

    2014-01-01

    This study investigates the effects of formality of dress on ratings of classroom presentations. Participants (N = 65, 66% women) from a Midwestern university in the United States rated three female students giving a presentation designed for a health psychology class in one of four outfits: casual, party, business casual, or business formal.…

  18. Approximate models for the study of exponential changed quantities: Application on the plasma waves growth rate or damping

    International Nuclear Information System (INIS)

    Xaplanteris, C. L.; Xaplanteris, L. C.; Leousis, D. P.

    2014-01-01

    Many physical phenomena that concern the research these days are basically complicated because of being multi-parametric. Thus, their study and understanding meets with big if not unsolved obstacles. Such complicated and multi-parametric is the plasmatic state as well, where the plasma and the physical quantities that appear along with it have chaotic behavior. Many of those physical quantities change exponentially and at most times they are stabilized by presenting wavy behavior. Mostly in the transitive state rather than the steady state, the exponentially changing quantities (Growth, Damping etc) depend on each other in most cases. Thus, it is difficult to distinguish the cause from the result. The present paper attempts to help this difficult study and understanding by proposing mathematical exponential models that could relate with the study and understanding of the plasmatic wavy instability behavior. Such instabilities are already detected, understood and presented in previous publications of our laboratory. In other words, our new contribution is the study of the already known plasmatic quantities by using mathematical models (modeling and simulation). These methods are both useful and applicable in the chaotic theory. In addition, our ambition is to also conduct a list of models useful for the study of chaotic problems, such as those that appear into the plasma, starting with this paper's examples

  19. Approximate models for the study of exponential changed quantities: Application on the plasma waves growth rate or damping

    Energy Technology Data Exchange (ETDEWEB)

    Xaplanteris, C. L., E-mail: cxaplanteris@yahoo.com [Plasma Physics Laboratory, IMS, NCSR “Demokritos”, Athens, Greece and Hellenic Army Academy, Vari Attica (Greece); Xaplanteris, L. C. [School of Physics, National and Kapodistrian University of Athens, Athens (Greece); Leousis, D. P. [Technical High School of Athens, Athens (Greece)

    2014-03-15

    Many physical phenomena that concern the research these days are basically complicated because of being multi-parametric. Thus, their study and understanding meets with big if not unsolved obstacles. Such complicated and multi-parametric is the plasmatic state as well, where the plasma and the physical quantities that appear along with it have chaotic behavior. Many of those physical quantities change exponentially and at most times they are stabilized by presenting wavy behavior. Mostly in the transitive state rather than the steady state, the exponentially changing quantities (Growth, Damping etc) depend on each other in most cases. Thus, it is difficult to distinguish the cause from the result. The present paper attempts to help this difficult study and understanding by proposing mathematical exponential models that could relate with the study and understanding of the plasmatic wavy instability behavior. Such instabilities are already detected, understood and presented in previous publications of our laboratory. In other words, our new contribution is the study of the already known plasmatic quantities by using mathematical models (modeling and simulation). These methods are both useful and applicable in the chaotic theory. In addition, our ambition is to also conduct a list of models useful for the study of chaotic problems, such as those that appear into the plasma, starting with this paper's examples.

  20. Adapting an evidence-based model to retain adolescent study participants in longitudinal research.

    Science.gov (United States)

    Davis, Erin; Demby, Hilary; Jenner, Lynne Woodward; Gregory, Alethia; Broussard, Marsha

    2016-02-01

    Maintaining contact with and collecting outcome data from adolescent study participants can present a significant challenge for researchers conducting longitudinal studies. Establishing an organized and effective protocol for participant follow-up is crucial to reduce attrition and maintain high retention rates. This paper describes our methods in using and adapting the evidence-based Engagement, Verification, Maintenance, and Confirmation (EVMC) model to follow up with adolescents 6 and 12 months after implementation of a health program. It extends previous research by focusing on two key modifications to the model: (1) the central role of cell phones and texting to maintain contact with study participants throughout the EVMC process and, (2) use of responsive two-way communication between staff and participants and flexible administration modes and methods in the confirmation phase to ensure that busy teens not only respond to contacts, but also complete data collection. These strategies have resulted in high overall retention rates (87-91%) with adolescent study participants at each follow-up data collection point without the utilization of other, more involved tracking measures. The methods and findings presented may be valuable for other researchers with limited resources planning for or engaged in collecting follow-up outcome data from adolescents enrolled in longitudinal studies. Copyright © 2015. Published by Elsevier Ltd.

  1. A wave model test bed study for wave energy resource characterization

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zhaoqing; Neary, Vincent S.; Wang, Taiping; Gunawan, Budi; Dallman, Annie R.; Wu, Wei-Cheng

    2017-12-01

    This paper presents a test bed study conducted to evaluate best practices in wave modeling to characterize energy resources. The model test bed off the central Oregon Coast was selected because of the high wave energy and available measured data at the site. Two third-generation spectral wave models, SWAN and WWIII, were evaluated. A four-level nested-grid approach—from global to test bed scale—was employed. Model skills were assessed using a set of model performance metrics based on comparing six simulated wave resource parameters to observations from a wave buoy inside the test bed. Both WWIII and SWAN performed well at the test bed site and exhibited similar modeling skills. The ST4 package with WWIII, which represents better physics for wave growth and dissipation, out-performed ST2 physics and improved wave power density and significant wave height predictions. However, ST4 physics tended to overpredict the wave energy period. The newly developed ST6 physics did not improve the overall model skill for predicting the six wave resource parameters. Sensitivity analysis using different wave frequencies and direction resolutions indicated the model results were not sensitive to spectral resolutions at the test bed site, likely due to the absence of complex bathymetric and geometric features.

  2. Environmental concentrations of engineered nanomaterials: Review of modeling and analytical studies

    International Nuclear Information System (INIS)

    Gottschalk, Fadri; Sun, TianYin; Nowack, Bernd

    2013-01-01

    Scientific consensus predicts that the worldwide use of engineered nanomaterials (ENM) leads to their release into the environment. We reviewed the available literature concerning environmental concentrations of six ENMs (TiO 2 , ZnO, Ag, fullerenes, CNT and CeO 2 ) in surface waters, wastewater treatment plant effluents, biosolids, sediments, soils and air. Presently, a dozen modeling studies provide environmental concentrations for ENM and a handful of analytical works can be used as basis for a preliminary validation. There are still major knowledge gaps (e.g. on ENM production, application and release) that affect the modeled values, but over all an agreement on the order of magnitude of the environmental concentrations can be reached. True validation of the modeled values is difficult because trace analytical methods that are specific for ENM detection and quantification are not available. The modeled and measured results are not always comparable due to the different forms and sizes of particles that these two approaches target. -- Highlights: •Modeled environmental concentrations of engineered nanomaterials are reviewed. •Measured environmental concentrations of engineered nanomaterials are reviewed. •Possible validation of modeled data by measurements is critically evaluated. •Different approaches in modeling and measurement methods complicate validation. -- Modeled and measured environmental concentrations of engineered nanomaterials are reviewed and critically discussed

  3. Varied Presentation of Schwannoma – A Case Study

    Directory of Open Access Journals (Sweden)

    Ruquaya Mir

    2010-10-01

    Full Text Available Schwannomas can occur anywhere in the body with unusual presentation. They are difficult to diagnose preoperatively. Fine needle aspiration biopsy does not appear to provide an accurate preoperative diagnosis. Complete excision of the mass should be the goal of surgical excision.

  4. Causes and outcomes of emergency presentation of rectal cancer.

    Science.gov (United States)

    Comber, Harry; Sharp, Linda; de Camargo Cancela, Marianna; Haase, Trutz; Johnson, Howard; Pratschke, Jonathan

    2016-09-01

    Emergency presentation of rectal cancer carries a relatively poor prognosis, but the roles and interactions of causative factors remain unclear. We describe an innovative statistical approach which distinguishes between direct and indirect effects of a number of contextual, patient and tumour factors on emergency presentation and outcome of rectal cancer. All patients diagnosed with rectal cancer in Ireland 2004-2008 were included. Registry information, linked to hospital discharge data, provided data on patient demographics, comorbidity and health insurance; population density and deprivation of area of residence; tumour type, site, grade and stage; treatment type and optimality; and emergency presentation and hospital caseload. Data were modelled using a structural equation model with a discrete-time survival outcome, allowing us to estimate direct and mediated effects of the above factors on hazard, and their inter-relationships. Two thousand seven hundred and fifty patients were included in the analysis. Around 12% had emergency presentations, which increased hazard by 80%. Affluence, private patient status and being married reduced hazard indirectly by reducing emergency presentation. Older patients had more emergency presentations, while married patients, private patients or those living in less deprived areas had fewer than expected. Patients presenting as an emergency were less likely to receive optimal treatment or to have this in a high caseload hospital. Apart from stage, emergency admission was the strongest determinant of poor survival. The factors contributing to emergency admission in this study are similar to those associated with diagnostic delay. The socio-economic gradient found suggests that patient education and earlier access to endoscopic investigation for public patients could reduce emergency presentation. © 2016 UICC.

  5. Study and mathematical model of ultra-low gas burner

    International Nuclear Information System (INIS)

    Gueorguieva, A.

    2001-01-01

    The main objective of this project is prediction and reduction of NOx and CO 2 emissions under levels recommended from European standards for gas combustion processes. A mathematical model of burner and combustion chamber is developed based on interacting fluid dynamics processes: turbulent flow, gas phase chemical reactions, heat and radiation transfer The NOx prediction model for prompt and thermal NOx is developed. The validation of CFD (Computer fluid-dynamics) simulations corresponds to 5 MWI burner type - TEA, installed on CASPER boiler. This burner is three-stream air distribution burner with swirl effect, designed by ENEL to meet future NOx emission standards. For performing combustion computer modelling, FLUENT CFD code is preferred, because of its capabilities to provide accurately description of large number of rapid interacting processes: turbulent flow, phase chemical reactions and heat transfer and for its possibilities to present wide range of calculation and graphical output reporting data The computational tool used in this study is FLUENT version 5.4.1, installed on fs 8200 UNIX systems The work includes: study the effectiveness of low-NOx concepts and understand the impact of combustion and swirl air distribution and flue gas recirculation on peak flame temperatures, flame structure and fuel/air mixing. A finite rate combustion model: Eddy-Dissipation (Magnussen-Hjertager) Chemical Model for 1, 2 step Chemical reactions of bi-dimensional (2D) grid is developed along with NOx and CO 2 predictions. The experimental part of the project consists of participation at combustion tests on experimental facilities located in Livorno. The results of the experiments are used, to obtain better vision for combustion process on small-scaled design and to collect the necessary input data for further Fluent simulations

  6. Phaeochromocytoma presenting with polyuria: an uncommon presentation of a rare tumour

    OpenAIRE

    Atapattu, N; Imalke, K A C P; Madarasinghe, M; Lamahewage, A; de Silva, K S H

    2014-01-01

    Summary Children rarely present with phaeochromocytoma. Their presentation differs from that of adults. The classic triad of sweating, headache and palpitation may not always present in children with phaeochromocytoma. In this study, we present a 6-year-old girl who came to us with polyuria and polydipsia for evaluation of suspected diabetes insipidus. She gave a clear history of increased sweating in the recent past. On clinical examination, she was noted to have high blood pressure. Subsequ...

  7. Study of a diffusion flamelet model, with preferential diffusion effects included

    NARCIS (Netherlands)

    Delhaye, S.; Somers, L.M.T.; Bongers, H.; Oijen, van J.A.; Goey, de L.P.H.; Dias, V.

    2005-01-01

    The non-premixed flamelet model of Peters [1] (model1), which does not include preferential diffusion effects is investigated. Two similar models are presented, but without the assumption of unity Lewis numbers. One of these models was derived by Peters & Pitsch [2] (model2), while the other one was

  8. The past, present and future of cyber-physical systems: a focus on models.

    Science.gov (United States)

    Lee, Edward A

    2015-02-26

    This paper is about better engineering of cyber-physical systems (CPSs) through better models. Deterministic models have historically proven extremely useful and arguably form the kingpin of the industrial revolution and the digital and information technology revolutions. Key deterministic models that have proven successful include differential equations, synchronous digital logic and single-threaded imperative programs. Cyber-physical systems, however, combine these models in such a way that determinism is not preserved. Two projects show that deterministic CPS models with faithful physical realizations are possible and practical. The first project is PRET, which shows that the timing precision of synchronous digital logic can be practically made available at the software level of abstraction. The second project is Ptides (programming temporally-integrated distributed embedded systems), which shows that deterministic models for distributed cyber-physical systems have practical faithful realizations. These projects are existence proofs that deterministic CPS models are possible and practical.

  9. Single breath study for lung scan with krypton-81m: proposition of a mathematical model

    International Nuclear Information System (INIS)

    Pommet, R.; Mathieu, E.

    1981-01-01

    A single breath study with sup(81m)Kr was proceeded in patients, and we studied a theorical model. Based on experimental datas, the model was extrapolated by simple compartimental hypothesis, permitting a study per area of the instant alveolar lung flow by a deconvolution operation. An other approach to present the local ventilation is proposed too. Based on the average flow of ventilation index, calculation is obtained easier than by deconvolution method, and this method fully agree with the proposed model. This index allows the realisation of functionnal views of the local ventilation flow, made possible by the use of a computer for the study of each elementary area of the lung and the realisation of the activity curve recorded during the sup(81m)Kr first breath [fr

  10. Model Servqual Dengan Pendekatan Structural Equation Modeling (Studi Pada Mahasiswa Sistem Informasi)

    OpenAIRE

    Nurfaizal, Yusmedi

    2015-01-01

    Penelitian ini berjudul “MODEL SERVQUAL DENGAN PENDEKATAN STRUCTURAL EQUATION MODELING (Studi Pada Mahasiswa Sistem Informasi)”. Tujuan penelitian ini adalah untuk mengetahui model Servqual dengan pendekatan Structural Equation Modeling pada mahasiswa sistem informasi. Peneliti memutuskan untuk mengambil sampel sebanyak 100 responden. Untuk menguji model digunakan analisis SEM. Hasil penelitian menunjukkan bahwa tangibility, reliability responsiveness, assurance dan emphaty mempunyai pengaruh...

  11. Experiences and Comparison Study of EPC & UML For Business Process & IS Modeling

    OpenAIRE

    Md. Rashedul Islam; Md. Rofiqul Islam; Md. Shariful Alam; Md. Shafiul Azam

    2011-01-01

    Business process modeling is an approach by which we can analyze and integrate the business process. Using the Business Process Modeling we can represent the current and future process of a business/organization/enterprise. The business process modeling is a prerequisite and essential implementing a business or making any automation system. In this paper, we present our experience in a Business Process Modeling for organization. This paper presents detailed description about business process ...

  12. Presentation and management of keloid scarring following median sternotomy: a case study

    Directory of Open Access Journals (Sweden)

    Javangula Kalyana C

    2010-12-01

    Full Text Available Abstract Introduction Keloid scars following median sternotomy are rare and occur more frequently in pigmented skin. Different management strategies have been described with variable success. We present a case of keloid scar formation following cardiac surgery including our management and the final aesthetic result. Case description A 64 year old female of fair complexion underwent mitral valve replacement. The procedure and postoperative recovery were uncomplicated, however, during the following year, thick keloid scars formed over the incision sites. Initial non surgical measures failed to relieve pain and did not offer any tangible aesthetic benefit. Eventually surgical excision was attempted. She presented to our clinic for nine months follow up with significant improvement in pain and aesthetic result. Discussion and Evaluation Several theories have attempted to explore the pathophysiology of keloid scar formation. A number of predisposing factors have been documented however none existed in this case. A variety of invasive and non invasive approaches have been described but significant differences in success rates and methodology of investigations still precludes a standardized management protocol. Conclusions In this case study a rare presentation of keloid scar has been presented. The variety of methods used to improve pain and aesthetic result demonstrates the propensity of keloid scars to recur and the therapeutic challenges that surgeons have to face in their quest for a satisfactory patient outcome.

  13. Presenting a comprehensive market oriented model and evaluating its impact on organization performance

    Directory of Open Access Journals (Sweden)

    Mohammad Taqi Amini

    2013-08-01

    Full Text Available Like other innovative strategies, companies have paid more attention to market oriented strategies in recent years. This has been focused by organizations for improved effectiveness and the organization performance accelerated a lot in business competition. In responding to this fact, organizations are trying to formulate many of the issues familiar to large organizations, which have involved with market oriented strategy planning. This paper reviews key elements in market-oriented strategy planning with regard to competitiveness and performance in large organizations and outlines a comprehensive model for strategy planning in profit organizations. These elements include environment, top management, organization structure and market oriented strategy. Professional question of this study has a particularly important role in formulating relations of this model. These elements are well positioned to evaluate the impact of market-oriented strategy planning on organizations and their expected impacts on organization performance. A well-organized questionnaire to help organizations with their planning is proposed in this survey. Based on the proposed questionnaire, data obtained from Tehran food industry experts and analyzed by using SEM method. Results accepted eight hypotheses and rejected one.

  14. Compartmental modeling alternatives for kinetic analysis of pet neurotransmitter receptor studies

    International Nuclear Information System (INIS)

    Koeppe, R.A.

    1991-01-01

    With the increased interest in studying neurotransmitter and receptor function in vivo, imaging procedures using positron emission tomography have presented new challenges for kinetic modeling and analysis of data. The in vivo behavior of radiolabeled markers for examining these neurotransmitter systems can be quite complex and, therefore, the implementation of compartmental models for data analysis is similarly complex. Often, the variability in the estimates of model parameters representing neurotransmitter or receptor densities, association and dissociation rates, or rates of incorporation or turnover does not permit reliable interpretation of the data. When less complex analyses are used, these model parameters may be biased and thus also do not yield the information being sought. Examination of trade-offs between uncertainty and bias in the parameters of interest may be used to select a compartmental model configuration with an appropriate level of complexity. Modeling alternatives will be discussed for radioligands with varying kinetic properties, such as those that bind reversibly and rapidly and others that bind nearly irreversibly. Specific problems, such as those occurring when a radioligand is open-quotes flow limitedclose quotes also will be discussed

  15. Stage at presentation of breast cancer in Luanda, Angola - a retrospective study.

    Science.gov (United States)

    Lopes, Lygia Vieira; Miguel, Fernando; Freitas, Helga; Tavares, António; Pangui, Salvador; Castro, Clara; Lacerda, Gonçalo Forjaz; Longatto-Filho, Adhemar; Weiderpass, Elisabete; Santos, Lúcio Lara

    2015-10-15

    It is expected that, by 2020, 15 million new cases of cancer will occur every year in the world, one million of them in Africa. Knowledge of cancer trends in African countries is far from adequate, and improvements in cancer prevention efforts are urgently needed. The aim of this study was to characterize breast cancer clinically and pathologically at presentation in Luanda, Angola; we additionally provide quality information that will be useful for breast cancer care planning in the country. Data on breast cancer cases were retrieved from the Angolan Institute of Cancer Control, from 2006 to 2014. For women diagnosed in 2009 (5-years of follow-up), demographic, clinical and pathological information, at presentation, was collected, namely age at diagnosis, parity, methods used for pathological diagnoses, tumor pathological characteristics, stage of disease and treatment. Descriptive statistics were performed. The median age of women diagnosed with breast cancer in 2009 was 47 years old (range 25-89). The most frequent clinical presentation was breast swelling with axillary lymph nodes metastasis (44.9 %), followed by a mass larger than 5 cm (14.2 %) and lump (12.9 %). Invasive ductal carcinoma was the main histologic type (81.8 %). Only 10.1 % of cancer cases had a well differentiated histological grade. Cancers were diagnosed mostly at advanced stages (66.7 % in stage III and 11.1 % in stage IV). In this study, breast cancer was diagnosed at a very advanced stage. Although it reports data from a single cancer center in Luanda, Angola it reinforces the need for early diagnosis and increasing awareness. According to the main challenges related to breast cancer diagnosis and treatment herein presented, we propose a realistic framework that would allow for the implementation of a breast cancer care program, built under a strong network based on cooperation, teaching, audit, good practices and the organization of health services. Angola needs urgently a program for

  16. The Past, Present and Future of Cyber-Physical Systems: A Focus on Models

    Science.gov (United States)

    Lee, Edward A.

    2015-01-01

    This paper is about better engineering of cyber-physical systems (CPSs) through better models. Deterministic models have historically proven extremely useful and arguably form the kingpin of the industrial revolution and the digital and information technology revolutions. Key deterministic models that have proven successful include differential equations, synchronous digital logic and single-threaded imperative programs. Cyber-physical systems, however, combine these models in such a way that determinism is not preserved. Two projects show that deterministic CPS models with faithful physical realizations are possible and practical. The first project is PRET, which shows that the timing precision of synchronous digital logic can be practically made available at the software level of abstraction. The second project is Ptides (programming temporally-integrated distributed embedded systems), which shows that deterministic models for distributed cyber-physical systems have practical faithful realizations. These projects are existence proofs that deterministic CPS models are possible and practical. PMID:25730486

  17. The Past, Present and Future of Cyber-Physical Systems: A Focus on Models

    Directory of Open Access Journals (Sweden)

    Edward A. Lee

    2015-02-01

    Full Text Available This paper is about better engineering of cyber-physical systems (CPSs through better models. Deterministic models have historically proven extremely useful and arguably form the kingpin of the industrial revolution and the digital and information technology revolutions. Key deterministic models that have proven successful include differential equations, synchronous digital logic and single-threaded imperative programs. Cyber-physical systems, however, combine these models in such a way that determinism is not preserved. Two projects show that deterministic CPS models with faithful physical realizations are possible and practical. The first project is PRET, which shows that the timing precision of synchronous digital logic can be practically made available at the software level of abstraction. The second project is Ptides (programming temporally-integrated distributed embedded systems, which shows that deterministic models for distributed cyber-physical systems have practical faithful realizations. These projects are existence proofs that deterministic CPS models are possible and practical.

  18. Multi-Decadal Variability in the Bering Sea: A Synthesis of Model Results and Observations from 1948 to the Present

    Science.gov (United States)

    2013-12-01

    stated that the development and use of high-resolution Arctic climate and systems models are important stepping stones for dedicated studies of...W., J. L. Clement Kinney, D. C. Marble , and J. Jakacki, 2008: Towards eddy resolving models of the Arctic Ocean: Ocean Modeling in an Eddying

  19. Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats

    Directory of Open Access Journals (Sweden)

    Zhixin Zhang

    2016-03-01

    Full Text Available Qingkailing injection (QKLI is a modern Chinese medicine preparation derived from a well-known classical formulation, An-Gong-Niu-Huang Wan. Although the clinical efficacy of QKLI has been well defined, its severe adverse drug reactions (ADRs were extensively increased. Through thorough attempts to reduce ADR rates, it was realized that the effect-based rational use plays the key role in clinical practices. Hence, the pharmacokinetic-pharmacodynamic (PK-PD model was introduced in the present study, aiming to link the pharmacokinetic profiles with the therapeutic outcomes of QKLI, and subsequently to provide valuable guidelines for the rational use of QKLI in clinical settings. The PK properties of the six dominant ingredients in QKLI were compared between the normal treated group (NTG and the pyrexia model group (MTG. Rectal temperatures were measured in parallel with blood sampling for NTG, MTG, model control group (MCG, and normal control group (NCG. Baicalin and geniposide exhibited appropriate PK parameters, and were selected as the PK markers to map the antipyretic effect of QKLI. Then, a PK-PD model was constructed upon the bacalin and geniposide plasma concentrations vs. the rectal temperature variation values, by a two-compartment PK model with a Sigmoid Emax PD model to explain the time delay between the drug plasma concentration of PK markers and the antipyretic effect after a single dose administration of QKLI. The findings obtained would provide fundamental information to propose a more reasonable dosage regimen and improve the level of individualized drug therapy in clinical settings.

  20. Beyond the CRAB symptoms: a study of presenting clinical manifestations of multiple myeloma.

    Science.gov (United States)

    Talamo, Giampaolo; Farooq, Umar; Zangari, Maurizio; Liao, Jason; Dolloff, Nathan G; Loughran, Thomas P; Epner, Elliot

    2010-12-01

    Although the typical clinical manifestations of multiple myeloma (MM) are summarized by the CRAB symptoms (hypercalcemia, renal insufficiency, anemia, and bone lesions), a significant proportion of patients with MM present with a variety of other clinical manifestations. We conducted a study evaluating the presenting symptoms that led to the diagnosis of MM. We conducted a retrospective review of 170 consecutive patients with MM seen at the Penn State Hershey Cancer Institute. Among patients with symptomatic MM, 74% presented with CRAB symptoms, 20% presented with non-CRAB manifestations, and 6% had both clinical features. Ten categories of non-CRAB manifestations were found, in order of decreasing frequency: neuropathy (because of spinal cord compression, nerve root compression, or peripheral neuropathy), extramedullary involvement, hyperviscosity syndrome, concomitant amyloidosis (eg, nephrotic syndrome or cardiopathy), hemorrhage/coagulopathy, systemic symptoms (eg, fever or weight loss), primary plasma cell leukemia, infections, cryoglobulinemia, and secondary gout. Kaplan-Meier estimates of survival in patients with non-CRAB manifestations did not show a significant difference from the survival of patients presenting with CRAB symptoms. Presenting symptoms of MM may be grouped in a total of 14 categories, 4 for the CRAB and 10 for the less common non-CRAB features. Grouped together, non-CRAB manifestations do not appear to confer a negative effect on the prognosis of patients with MM.

  1. Study of melting of molecular crystals by a modified Pople-Karasz model

    Science.gov (United States)

    Yazıcı, Mustafa; Özgan, Şükrü; Keskin, Mustafa

    2005-02-01

    A new modified model that combines the modified models of Chandrasekhar et al. with those of Keskin and Özgan, which are based on the Pople-Karasz theory, is applied to study the thermodynamics of melting and solid-solid transitions of molecular crystals. The thermodynamic properties of the disordered system are evaluated relative to those of the perfectly ordered one using the lowest approximation of the cluster-variation method, which is identical to the mean-field approximation. A good agreement is found between the present modified theory and the available experimental data. For melting transitions the agreement is excellent and much better than with the calculations of the Pople-Karasz theory and its previous modified theories. Approximate agreement is obtained for the solid-solid transitions. However, for these transition the experimental agreement with the present modified theory is still better than previous modified theories except at zero and low pressures.

  2. Mean Value SI Engine Model for Control Studies

    DEFF Research Database (Denmark)

    Hendricks, Elbert; Sorenson, Spencer C

    1990-01-01

    This paper presents a mathematically simple nonlinear three state (three differential equation) dynamic model of an SI engine which has the same steady state accuracy as a typical dynamometer measurement of the engine over its entire speed/load operating range (± 2.0%). The model's accuracy...... for large, fast transients is of the same order in the same operating region. Because the model is mathematically compact, it has few adjustable parameters and is thus simple to fit to a given engine either on the basis of measurements or given the steady state results of a larger cycle simulation package....... The model can easily be run on a Personal Computer (PC) using a ordinary differential equation (ODE) integrating routine or package. This makes the model is useful for control system design and evaluation....

  3. Fuzzy net present value for engineering analysis

    Directory of Open Access Journals (Sweden)

    Ali Nazeri

    2012-10-01

    Full Text Available Cash flow analysis is one of the most popular methods for investigating the outcome of an economical project. The costs and benefits of a construction project are often involved with uncertainty and it is not possible to find a precise value for a particular project. In this paper, we present a simple method to calculate the net present value of a cash flow when both costs and benefits are given as triangular numbers. The proposed model of this paper uses Delphi method to figure out the fair values of all costs and revenues and then using fizzy programming techniques, it calculates the fuzzy net present value. The implementation of the proposed model is demonstrated using a simple example.

  4. Insect symbioses: a case study of past, present, and future fungus-growing ant research

    DEFF Research Database (Denmark)

    Caldera, Eric J; Poulsen, Michael; Suen, Garret

    2009-01-01

    's fungus garden, antibiotic-producing actinobacteria that help protect the fungus garden from the parasite, and a black yeast that parasitizes the ant-actinobacteria mutualism. The fungus-growing ant symbiosis serves as a particularly useful model system for studying insect-microbe symbioses, because...

  5. A Coupled GCM-Cloud Resolving Modeling System, and a Regional Scale Model to Study Precipitation Processes

    Science.gov (United States)

    Tao, Wei-Kuo

    2007-01-01

    Recent GEWEX Cloud System Study (GCSS) model comparison projects have indicated that cloud-resolving models (CRMs) agree with observations better than traditional single-column models in simulating various types of clouds and cloud systems from different geographic locations. Current and future NASA satellite programs can provide cloud, precipitation, aerosol and other data at very fine spatial and temporal scales. It requires a coupled global circulation model (GCM) and cloud-scale model (termed a superparameterization or multi-scale modeling framework, MMF) to use these satellite data to improve the understanding of the physical processes that are responsible for the variation in global and regional climate and hydrological systems. The use of a GCM will enable global coverage, and the use of a CRM will allow for better and more sophisticated physical parameterization. NASA satellite and field campaign cloud related datasets can provide initial conditions as well as validation for both the MMF and CRMs. The Goddard MMF is based on the 2D Goddard Cumulus Ensemble (GCE) model and the Goddard finite volume general circulation model (fvGCM), and it has started production runs with two years results (1998 and 1999). Also, at Goddard, we have implemented several Goddard microphysical schemes (2ICE, several 31CE), Goddard radiation (including explicitly calculated cloud optical properties), and Goddard Land Information (LIS, that includes the CLM and NOAH land surface models) into a next generatio11 regional scale model, WRF. In this talk, I will present: (1) A brief review on GCE model and its applications on precipitation processes (microphysical and land processes), (2) The Goddard MMF and the major difference between two existing MMFs (CSU MMF and Goddard MMF), and preliminary results (the comparison with traditional GCMs), and (3) A discussion on the Goddard WRF version (its developments and applications).

  6. A Study of Simple Diffraction Models

    DEFF Research Database (Denmark)

    Agerkvist, Finn

    In this paper two simple methods for cabinet edge diffraction are examined. Calculations with both models are compared with more sophisticated theoretical models and with measured data. The parameters involved are studied and their importance for normal loudspeaker box designs is examined....

  7. Fluid prediction using rock modelling and reconnaissance. AVO analysis - A case study from the North Sea

    Energy Technology Data Exchange (ETDEWEB)

    Osdal, Bard; Granli, John Reidar

    1998-12-31

    Seismic lithology and fluid phase prediction (LFP) is becoming an important part of seismic interpretation, and can contribute significantly to risk reduction prior to drilling. In this presentation there is focused on quantitative interpretation of the amplitudes in a 2-D dataset, with respect to presence of hydrocarbons. Different aspect of the working producer, like data quality (well data and seismic data), rock modelling and seismic modelling will be illustrated. In the present study only one well has been used for calibration and to investigate the seismic response for different fluid and lithology scenarios. The rock modelling included evaluation of seismic parameter effect for different fluid and porosities. 1 ref., 4 figs.

  8. The present state and future directions of PDF methods

    Science.gov (United States)

    Pope, S. B.

    1992-01-01

    The objectives of the workshop are presented in viewgraph format, as is this entire article. The objectives are to discuss the present status and the future direction of various levels of engineering turbulence modeling related to Computational Fluid Dynamics (CFD) computations for propulsion; to assure that combustion is an essential part of propulsion; and to discuss Probability Density Function (PDF) methods for turbulent combustion. Essential to the integration of turbulent combustion models is the development of turbulent model, chemical kinetics, and numerical method. Some turbulent combustion models typically used in industry are the k-epsilon turbulent model, the equilibrium/mixing limited combustion, and the finite volume codes.

  9. Scientific Presenting: Using Evidence-Based Classroom Practices to Deliver Effective Conference Presentations

    Science.gov (United States)

    Corwin, Lisa A.; Prunuske, Amy; Seidel, Shannon B.

    2018-01-01

    Scientists and educators travel great distances, spend significant time, and dedicate substantial financial resources to present at conferences. This highlights the value placed on conference interactions. Despite the importance of conferences, very little has been studied about what is learned from the presentations and how presenters can…

  10. A heat transfer correlation based on a surface renewal model for molten core concrete interaction study

    International Nuclear Information System (INIS)

    Tourniaire, B. . E-mail bruno.tourniaire@cea.fr

    2006-01-01

    The prediction of heat transfer between corium pool and concrete basemat is of particular significance in the framework of the study of PWR's severe accident. Heat transfer directly governs the ablation velocity of concrete in case of molten core concrete interaction (MCCI) and, consequently, the time delay when the reactor cavity may fail. From a restricted hydrodynamic point of view, this issue is related to heat transfer between a heated bubbling pool and a porous wall with gas injection. Several experimental studies have been performed with simulant materials and many correlations have been provided to address this issue. The comparisons of the results of these correlations with the measurements and their extrapolation to reactor materials show that strong discrepancies between the results of these models are obtained which probably means that some phenomena are not well taken into account. The main purpose of this paper is to present an alternative heat transfer model which was originally developed for chemical engineering applications (bubble columns) by Deckwer. A part of this work is devoted to the presentation of this model, which is based on a surface renewal assumption. Comparison of the results of this model with available experimental data in different systems are presented and discussed. These comparisons clearly show that this model can be used to deal with the particular problem of MCCI. The analyses also lead to enrich the original model by taking into account the thermal resistance of the wall: a new formulation of the Deckwer's correlation is finally proposed

  11. A coarse resolution North Atlantic ocean circulation model: an intercomparison study with a paleoceanographic example

    Directory of Open Access Journals (Sweden)

    Dan Seidov

    Full Text Available Paleoreconstructions suggest that during the Last Glacial Maximum (LGM the North Atlantic circulation was noticeably different from its present state. However, the glacial salt conveyor belt is believed to be similar to the present-day's conveyor, albeit weaker and shallower because of an increased freshwater flux in high-latitudes. We present here the investigation of the conveyor operation based on ocean circulation modelling using two numerical models in parallel. The GFDL primitive equation model and a planetary geostrophic model are employed to address the problem of the paleocirculation modelling in cases of uncertain and sparse data comprising the glacial surface boundary conditions. The role of different simplifications that may be used in the ocean climate studies, including the role of grid resolution, bottom topography, coast-line, etc., versus glacial-interglacial changes of the ocean surface climatology is considered. The LGM reverse conveyor gyre appeared to be the most noticeable feature of the glacial-to-interglacial alteration of the ocean circulation. The reversed upper-ocean conveyor, weaker and subducting 'normal' conveyor in the intermediate depths, and the change of the deep-ocean return flow route are robust signatures of the glacial North Atlantic climate. The results are found to be 'model-independent' and fairly insensitive to all factors other than the onset of the glacial surface conditions.

  12. A coarse resolution North Atlantic ocean circulation model: an intercomparison study with a paleoceanographic example

    Directory of Open Access Journals (Sweden)

    D. Seidov

    1996-02-01

    Full Text Available Paleoreconstructions suggest that during the Last Glacial Maximum (LGM the North Atlantic circulation was noticeably different from its present state. However, the glacial salt conveyor belt is believed to be similar to the present-day's conveyor, albeit weaker and shallower because of an increased freshwater flux in high-latitudes. We present here the investigation of the conveyor operation based on ocean circulation modelling using two numerical models in parallel. The GFDL primitive equation model and a planetary geostrophic model are employed to address the problem of the paleocirculation modelling in cases of uncertain and sparse data comprising the glacial surface boundary conditions. The role of different simplifications that may be used in the ocean climate studies, including the role of grid resolution, bottom topography, coast-line, etc., versus glacial-interglacial changes of the ocean surface climatology is considered. The LGM reverse conveyor gyre appeared to be the most noticeable feature of the glacial-to-interglacial alteration of the ocean circulation. The reversed upper-ocean conveyor, weaker and subducting 'normal' conveyor in the intermediate depths, and the change of the deep-ocean return flow route are robust signatures of the glacial North Atlantic climate. The results are found to be 'model-independent' and fairly insensitive to all factors other than the onset of the glacial surface conditions.

  13. Numerical modelling of the flow in the resin infusion process on the REV scale: A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Jabbari, M.; Spangenberg, J.; Hattel, J. H. [Process Modelling Group, Department of Mechanical Engineering, Technical University of Denmark, Nils Koppels Allé, 2800 Kgs. Lyngby (Denmark); Jambhekar, V. A.; Helmig, R. [Department of Hydromechanics and Modelling of Hydrosystems, Institute for Modelling Hydraulic and Environmental Systems, Universität Stuttgart, Stuttgart (Germany); Gersborg, A. R. [SCION DTU, Diplomvej 373N, DK-2800 Lyngby (Denmark)

    2016-06-08

    The resin infusion process (RIP) has developed as a low cost method for manufacturing large fibre reinforced plastic parts. However, the process still presents some challenges to industry with regards to reliability and repeatability, resulting in expensive and inefficient trial and error development. In this paper, we show the implementation of 2D numerical models for the RIP using the open source simulator DuMu{sup X}. The idea of this study is to present a model which accounts for the interfacial forces coming from the capillary pressure on the so-called representative elementary volume (REV) scale. The model is described in detail and three different test cases — a constant and a tensorial permeability as well as a preform/Balsa domain — are investigated. The results show that the developed model is very applicable for the RIP for manufacturing of composite parts. The idea behind this study is to test the developed model for later use in a real application, in which the preform medium has numerous layers with different material properties.

  14. Using Multi-Scale Modeling Systems and Satellite Data to Study the Precipitation Processes

    Science.gov (United States)

    Tao, Wei-Kuo; Chern, J.; Lamg, S.; Matsui, T.; Shen, B.; Zeng, X.; Shi, R.

    2011-01-01

    In recent years, exponentially increasing computer power has extended Cloud Resolving Model (CRM) integrations from hours to months, the number of computational grid points from less than a thousand to close to ten million. Three-dimensional models are now more prevalent. Much attention is devoted to precipitating cloud systems where the crucial 1-km scales are resolved in horizontal domains as large as 10,000 km in two-dimensions, and 1,000 x 1,000 km2 in three-dimensions. Cloud resolving models now provide statistical information useful for developing more realistic physically based parameterizations for climate models and numerical weather prediction models. It is also expected that NWP and mesoscale model can be run in grid size similar to cloud resolving model through nesting technique. Recently, a multi-scale modeling system with unified physics was developed at NASA Goddard. It consists of (l) a cloud-resolving model (Goddard Cumulus Ensemble model, GCE model), (2) a regional scale model (a NASA unified weather research and forecast, WRF), (3) a coupled CRM and global model (Goddard Multi-scale Modeling Framework, MMF), and (4) a land modeling system. The same microphysical processes, long and short wave radiative transfer and land processes and the explicit cloud-radiation, and cloud-land surface interactive processes are applied in this multi-scale modeling system. This modeling system has been coupled with a multi-satellite simulator to use NASA high-resolution satellite data to identify the strengths and weaknesses of cloud and precipitation processes simulated by the model. In this talk, the recent developments and applications of the multi-scale modeling system will be presented. In particular, the results from using multi-scale modeling system to study the precipitating systems and hurricanes/typhoons will be presented. The high-resolution spatial and temporal visualization will be utilized to show the evolution of precipitation processes. Also how to

  15. Regression to Causality : Regression-style presentation influences causal attribution

    DEFF Research Database (Denmark)

    Bordacconi, Mats Joe; Larsen, Martin Vinæs

    2014-01-01

    of equivalent results presented as either regression models or as a test of two sample means. Our experiment shows that the subjects who were presented with results as estimates from a regression model were more inclined to interpret these results causally. Our experiment implies that scholars using regression...... models – one of the primary vehicles for analyzing statistical results in political science – encourage causal interpretation. Specifically, we demonstrate that presenting observational results in a regression model, rather than as a simple comparison of means, makes causal interpretation of the results...... more likely. Our experiment drew on a sample of 235 university students from three different social science degree programs (political science, sociology and economics), all of whom had received substantial training in statistics. The subjects were asked to compare and evaluate the validity...

  16. The ELOCA fuel modelling code: past, present and future

    International Nuclear Information System (INIS)

    Williams, A.F.

    2005-01-01

    ELOCA is the Industry Standard Toolset (IST) computer code for modelling CANDU fuel under the transient coolant conditions typical of an accident scenario. Since its original inception in the early 1970's, the code has undergone continual development and improvement. The code now embodies much of the knowledge and experience of fuel behaviour gained by the Canadian nuclear industry over this period. ELOCA has proven to be a valuable tool for the safety analyst, and continues to be used extensively to support the licensing cases of CANDU reactors. This paper provides a brief and much simplified view of this development history, its current status, and plans for future development. (author)

  17. Perception of Sexual Orientation from Facial Structure: A Study with Artificial Face Models.

    Science.gov (United States)

    González-Álvarez, Julio

    2017-07-01

    Research has shown that lay people can perceive sexual orientation better than chance from face stimuli. However, the relation between facial structure and sexual orientation has been scarcely examined. Recently, an extensive morphometric study on a large sample of Canadian people (Skorska, Geniole, Vrysen, McCormick, & Bogaert, 2015) identified three (in men) and four (in women) facial features as unique multivariate predictors of sexual orientation in each sex group. The present study tested the perceptual validity of these facial traits with two experiments based on realistic artificial 3D face models created by manipulating the key parameters and presented to Spanish participants. Experiment 1 included 200 White and Black face models of both sexes. The results showed an overall accuracy (0.74) clearly above chance in a binary hetero/homosexual judgment task and significant differences depending on the race and sex of the face models. Experiment 2 produced five versions of 24 artificial faces of both sexes varying the key parameters in equal steps, and participants had to rate on a 1-7 scale how likely they thought that the depicted person had a homosexual sexual orientation. Rating scores displayed an almost perfect linear regression as a function of the parameter steps. In summary, both experiments demonstrated the perceptual validity of the seven multivariate predictors identified by Skorska et al. and open up new avenues for further research on this issue with artificial face models.

  18. Attention shifts the language network reflecting paradigm presentation

    Directory of Open Access Journals (Sweden)

    Kathrin eKollndorfer

    2013-11-01

    Full Text Available Objectives: Functional magnetic resonance imaging (fMRI is a reliable and non-invasive method with which to localize language function in pre-surgical planning. In clinical practice, visual stimulus presentation is often difficult or impossible, due to the patient’s restricted language or attention abilities. Therefore, our aim was to investigate modality-specific differences in visual and auditory stimulus presentation.Methods: Ten healthy subjects participated in an fMRI study comprising two experiments with visual and auditory stimulus presentation. In both experiments, two language paradigms (one for language comprehension and one for language production used in clinical practice were investigated. In addition to standard data analysis by the means of the general linear model (GLM, independent component analysis (ICA was performed to achieve more detailed information on language processing networks.Results: GLM analysis revealed modality-specific brain activation for both language paradigms for the contrast visual > auditory in the area of the intraparietal sulcus and the hippocampus, two areas related to attention and working memory. Using group ICA, a language network was detected for both paradigms independent of stimulus presentation modality. The investigation of language lateralization revealed no significant variations. Visually presented stimuli further activated an attention-shift network, which could not be identified for the auditory presented language.Conclusion: The results of this study indicate that the visually presented language stimuli additionally activate an attention-shift network. These findings will provide important information for pre-surgical planning in order to preserve reading abilities after brain surgery, significantly improving surgical outcomes. Our findings suggest that the presentation modality for language paradigms should be adapted on behalf of individual indication.

  19. Improving the accessibility and re-use of environmental models through provision of model metadata - a scoping study

    Science.gov (United States)

    Riddick, Andrew; Hughes, Andrew; Harpham, Quillon; Royse, Katherine; Singh, Anubha

    2014-05-01

    There has been an increasing interest both from academic and commercial organisations over recent years in developing hydrologic and other environmental models in response to some of the major challenges facing the environment, for example environmental change and its effects and ensuring water resource security. This has resulted in a significant investment in modelling by many organisations both in terms of financial resources and intellectual capital. To capitalise on the effort on producing models, then it is necessary for the models to be both discoverable and appropriately described. If this is not undertaken then the effort in producing the models will be wasted. However, whilst there are some recognised metadata standards relating to datasets these may not completely address the needs of modellers regarding input data for example. Also there appears to be a lack of metadata schemes configured to encourage the discovery and re-use of the models themselves. The lack of an established standard for model metadata is considered to be a factor inhibiting the more widespread use of environmental models particularly the use of linked model compositions which fuse together hydrologic models with models from other environmental disciplines. This poster presents the results of a Natural Environment Research Council (NERC) funded scoping study to understand the requirements of modellers and other end users for metadata about data and models. A user consultation exercise using an on-line questionnaire has been undertaken to capture the views of a wide spectrum of stakeholders on how they are currently managing metadata for modelling. This has provided a strong confirmation of our original supposition that there is a lack of systems and facilities to capture metadata about models. A number of specific gaps in current provision for data and model metadata were also identified, including a need for a standard means to record detailed information about the modelling

  20. A comprehensive experimental and modeling study of iso-pentanol combustion

    KAUST Repository

    Sarathy, Mani

    2013-12-01

    Biofuels are considered as potentially attractive alternative fuels that can reduce greenhouse gas and pollutant emissions. iso-Pentanol is one of several next-generation biofuels that can be used as an alternative fuel in combustion engines. In the present study, new experimental data for iso-pentanol in shock tube, rapid compression machine, jet stirred reactor, and counterflow diffusion flame are presented. Shock tube ignition delay times were measured for iso-pentanol/air mixtures at three equivalence ratios, temperatures ranging from 819 to 1252. K, and at nominal pressures near 40 and 60. bar. Jet stirred reactor experiments are reported at 5. atm and five equivalence ratios. Rapid compression machine ignition delay data was obtained near 40. bar, for three equivalence ratios, and temperatures below 800. K. Laminar flame speed data and non-premixed extinction strain rates were obtained using the counterflow configuration. A detailed chemical kinetic model for iso-pentanol oxidation was developed including high- and low-temperature chemistry for a better understanding of the combustion characteristics of higher alcohols. First, bond dissociation energies were calculated using ab initio methods, and the proposed rate constants were based on a previously presented model for butanol isomers and n-pentanol. The model was validated against new and existing experimental data at pressures of 1-60. atm, temperatures of 650-1500. K, equivalence ratios of 0.25-4.0, and covering both premixed and non-premixed environments. The method of direct relation graph (DRG) with expert knowledge (DRGX) was employed to eliminate unimportant species and reactions in the detailed mechanism, and the resulting skeletal mechanism was used to predict non-premixed flames. In addition, reaction path and temperature A-factor sensitivity analyses were conducted for identifying key reactions at various combustion conditions. © 2013 The Combustion Institute.

  1. A comprehensive experimental and modeling study of iso-pentanol combustion

    KAUST Repository

    Sarathy, Mani; Park, Sungwoo; Weber, Bryan W.; Wang, Weijing; Veloo, Peter S.; Davis, Alexander C.; Togbé , Casimir; Westbrook, Charles K.; Park, Okjoo; Dayma, Guillaume; Luo, Zhaoyu; Oehlschlaeger, Matthew A.; Egolfopoulos, Fokion N.; Lu, Tianfeng; Pitz, William J.; Sung, Chihjen; Dagaut, P.

    2013-01-01

    Biofuels are considered as potentially attractive alternative fuels that can reduce greenhouse gas and pollutant emissions. iso-Pentanol is one of several next-generation biofuels that can be used as an alternative fuel in combustion engines. In the present study, new experimental data for iso-pentanol in shock tube, rapid compression machine, jet stirred reactor, and counterflow diffusion flame are presented. Shock tube ignition delay times were measured for iso-pentanol/air mixtures at three equivalence ratios, temperatures ranging from 819 to 1252. K, and at nominal pressures near 40 and 60. bar. Jet stirred reactor experiments are reported at 5. atm and five equivalence ratios. Rapid compression machine ignition delay data was obtained near 40. bar, for three equivalence ratios, and temperatures below 800. K. Laminar flame speed data and non-premixed extinction strain rates were obtained using the counterflow configuration. A detailed chemical kinetic model for iso-pentanol oxidation was developed including high- and low-temperature chemistry for a better understanding of the combustion characteristics of higher alcohols. First, bond dissociation energies were calculated using ab initio methods, and the proposed rate constants were based on a previously presented model for butanol isomers and n-pentanol. The model was validated against new and existing experimental data at pressures of 1-60. atm, temperatures of 650-1500. K, equivalence ratios of 0.25-4.0, and covering both premixed and non-premixed environments. The method of direct relation graph (DRG) with expert knowledge (DRGX) was employed to eliminate unimportant species and reactions in the detailed mechanism, and the resulting skeletal mechanism was used to predict non-premixed flames. In addition, reaction path and temperature A-factor sensitivity analyses were conducted for identifying key reactions at various combustion conditions. © 2013 The Combustion Institute.

  2. A comparative study of velocity increment generation between the rigid body and flexible models of MMET

    Energy Technology Data Exchange (ETDEWEB)

    Ismail, Norilmi Amilia, E-mail: aenorilmi@usm.my [School of Aerospace Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Pulau Pinang (Malaysia)

    2016-02-01

    The motorized momentum exchange tether (MMET) is capable of generating useful velocity increments through spin–orbit coupling. This study presents a comparative study of the velocity increments between the rigid body and flexible models of MMET. The equations of motions of both models in the time domain are transformed into a function of true anomaly. The equations of motion are integrated, and the responses in terms of the velocity increment of the rigid body and flexible models are compared and analysed. Results show that the initial conditions, eccentricity, and flexibility of the tether have significant effects on the velocity increments of the tether.

  3. Modeling study of solute transport in the unsaturated zone: Workshop proceedings

    International Nuclear Information System (INIS)

    Springer, E.P.; Fuentes, H.R.

    1987-04-01

    Issues addressed were the adequacy of the data for the various models, effectiveness of the models to represent the data, particular information provided by the models, the role of caisson experiments in providing fundamental knowledge of porous-media water flow and solute transport, and the importance of geochemistry to the transport of nonconservative tracers. These proceedings include the presentations made by each of the modelers; the summary document written by the panel; and a transcript of the discussions, both the discussions that followed individual presentations and the general discussion held on the second day. This publication completes the series on the workshop. Volume I in the series (NUREG/CR-4615, Vol. I) contains background information and the data sets provided each modeler

  4. Selected Papers and Presentations Presented at MODSIM World 2010 Conference Expo. Part 2

    Science.gov (United States)

    Pinelli, Thomas E. (Editor)

    2011-01-01

    MODSIM World 2010 was held in Hampton, Virginia, October 13-15, 2010. The theme of the 2010 conference & expo was "21st Century Decision-Making: The Art of Modeling& Simulation". The conference program consisted of seven technical tracks - Defense, Engineering and Science, Health & Medicine, Homeland Security & First Responders, The Human Dimension, K-20 STEM Education, and Serious Games & Virtual Worlds. Selected papers and presentations from MODSIM World 2010 Conference & Expo are contained in this NASA Conference Publication (CP). Section 8.0 of this CP contains papers from MODSIM World 2009 Conference & Expo that were unavailable at the time of publication of NASA/CP-2010-216205 Selected Papers Presented at MODSIM World 2009 Conference and Expo, March 2010.

  5. A Novel 3D Skin Explant Model to Study Anaerobic Bacterial Infection

    Directory of Open Access Journals (Sweden)

    Grazieli Maboni

    2017-09-01

    Full Text Available Skin infection studies are often limited by financial and ethical constraints, and alternatives, such as monolayer cell culture, do not reflect many cellular processes limiting their application. For a more functional replacement, 3D skin culture models offer many advantages such as the maintenance of the tissue structure and the cell types present in the host environment. A 3D skin culture model can be set up using tissues acquired from surgical procedures or post slaughter, making it a cost effective and attractive alternative to animal experimentation. The majority of 3D culture models have been established for aerobic pathogens, but currently there are no models for anaerobic skin infections. Footrot is an anaerobic bacterial infection which affects the ovine interdigital skin causing a substantial animal welfare and financial impact worldwide. Dichelobacter nodosus is a Gram-negative anaerobic bacterium and the causative agent of footrot. The mechanism of infection and host immune response to D. nodosus is poorly understood. Here we present a novel 3D skin ex vivo model to study anaerobic bacterial infections using ovine skin explants infected with D. nodosus. Our results demonstrate that D. nodosus can invade the skin explant, and that altered expression of key inflammatory markers could be quantified in the culture media. The viability of explants was assessed by tissue integrity (histopathological features and cell death (DNA fragmentation over 76 h showing the model was stable for 28 h. D. nodosus was quantified in all infected skin explants by qPCR and the bacterium was visualized invading the epidermis by Fluorescent in situ Hybridization. Measurement of pro-inflammatory cytokines/chemokines in the culture media revealed that the explants released IL1β in response to bacteria. In contrast, levels of CXCL8 production were no different to mock-infected explants. The 3D skin model realistically simulates the interdigital skin and has

  6. Study and discretization of kinetic models and fluid models at low Mach number

    International Nuclear Information System (INIS)

    Dellacherie, Stephane

    2011-01-01

    This thesis summarizes our work between 1995 and 2010. It concerns the analysis and the discretization of Fokker-Planck or semi-classical Boltzmann kinetic models and of Euler or Navier-Stokes fluid models at low Mach number. The studied Fokker-Planck equation models the collisions between ions and electrons in a hot plasma, and is here applied to the inertial confinement fusion. The studied semi-classical Boltzmann equations are of two types. The first one models the thermonuclear reaction between a deuterium ion and a tritium ion producing an α particle and a neutron particle, and is also in our case used to describe inertial confinement fusion. The second one (known as the Wang-Chang and Uhlenbeck equations) models the transitions between electronic quantified energy levels of uranium and iron atoms in the AVLIS isotopic separation process. The basic properties of these two Boltzmann equations are studied, and, for the Wang-Chang and Uhlenbeck equations, a kinetic-fluid coupling algorithm is proposed. This kinetic-fluid coupling algorithm incited us to study the relaxation concept for gas and immiscible fluids mixtures, and to underline connections with classical kinetic theory. Then, a diphasic low Mach number model without acoustic waves is proposed to model the deformation of the interface between two immiscible fluids induced by high heat transfers at low Mach number. In order to increase the accuracy of the results without increasing computational cost, an AMR algorithm is studied on a simplified interface deformation model. These low Mach number studies also incited us to analyse on cartesian meshes the inaccuracy at low Mach number of Godunov schemes. Finally, the LBM algorithm applied to the heat equation is justified

  7. Sensitivity studies using the TRNSM 2 computerized model for the NRC physical protection project. Final report

    International Nuclear Information System (INIS)

    Anderson, G.M.

    1979-08-01

    A computerized model of the transportation system for shipment of nuclear fuel cycle materials is required to investigate the effects on fleet size, fleet composition and efficiency of fleet utilization resulting from changes in a variety of physical and regulatory factors, including shipping requirements, security regulations, work rules, maintenance requirements, and vehicle capacities. Such a model has been developed which provides a capability for complete sizing requirements studies of a combined aircraft and truck fleet. This report presents the results of a series of sensitivity studies performed using this model. These studies include the effects of the intinerary optimization criteria, work rules, and maintenance policies. These results demonstrate the effectiveness and versatility of the model for investigating the effects of a wide variety of physical and regulatory factors on the transportation fleet

  8. Boolean Dynamic Modeling Approaches to Study Plant Gene Regulatory Networks: Integration, Validation, and Prediction.

    Science.gov (United States)

    Velderraín, José Dávila; Martínez-García, Juan Carlos; Álvarez-Buylla, Elena R

    2017-01-01

    Mathematical models based on dynamical systems theory are well-suited tools for the integration of available molecular experimental data into coherent frameworks in order to propose hypotheses about the cooperative regulatory mechanisms driving developmental processes. Computational analysis of the proposed models using well-established methods enables testing the hypotheses by contrasting predictions with observations. Within such framework, Boolean gene regulatory network dynamical models have been extensively used in modeling plant development. Boolean models are simple and intuitively appealing, ideal tools for collaborative efforts between theorists and experimentalists. In this chapter we present protocols used in our group for the study of diverse plant developmental processes. We focus on conceptual clarity and practical implementation, providing directions to the corresponding technical literature.

  9. Alveolocapillary model system to study alveolar re-epithelialization

    Energy Technology Data Exchange (ETDEWEB)

    Willems, Coen H.M.P.; Zimmermann, Luc J.I.; Sanders, Patricia J.L.T.; Wagendorp, Margot; Kloosterboer, Nico [Department of Paediatrics, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Maastricht (Netherlands); Cohen Tervaert, Jan Willem [Division of Clinical and Experimental Immunology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht (Netherlands); Duimel, Hans J.Q.; Verheyen, Fons K.C.P. [Electron Microscopy Unit, Department of Molecular Cell Biology, Maastricht University Medical Centre, Maastricht (Netherlands); Iwaarden, J. Freek van, E-mail: f.vaniwaarden@maastrichtuniversity.nl [Department of Paediatrics, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Maastricht (Netherlands)

    2013-01-01

    In the present study an in vitro bilayer model system of the pulmonary alveolocapillary barrier was established to investigate the role of the microvascular endothelium on re-epithelialization. The model system, confluent monolayer cultures on opposing sides of a porous membrane, consisted of a human microvascular endothelial cell line (HPMEC-ST1.6R) and an alveolar type II like cell line (A549), stably expressing EGFP and mCherry, respectively. These fluorescent proteins allowed the real time assessment of the integrity of the monolayers and the automated analysis of the wound healing process after a scratch injury. The HPMECs significantly attenuated the speed of re-epithelialization, which was associated with the proximity to the A549 layer. Examination of cross-sectional transmission electron micrographs of the model system revealed protrusions through the membrane pores and close contact between the A549 cells and the HPMECs. Immunohistochemical analysis showed that these close contacts consisted of heterocellular gap-, tight- and adherens-junctions. Additional analysis, using a fluorescent probe to assess gap-junctional communication, revealed that the HPMECs and A549 cells were able to exchange the fluorophore, which could be abrogated by disrupting the gap junctions using connexin mimetic peptides. These data suggest that the pulmonary microvascular endothelium may impact the re-epithelialization process. -- Highlights: ► Model system for vital imaging and high throughput screening. ► Microvascular endothelium influences re-epithelialization. ► A549 cells form protrusions through membrane to contact HPMEC. ► A549 cells and HPMECs form heterocellular tight-, gap- and adherens-junctions.

  10. Economic modeling and parametric studies for SOMBRERO - a laser-driven IFE power plant

    International Nuclear Information System (INIS)

    Meier, W.R.; Rosenberg, C.W. Jr. von

    1992-01-01

    Economic modeling and parametric studies for the SOMBRERO laser-driven inertial fusion energy (IFE) electric power plant have been conducted to determine the most attractive operating point. Cost scaling relationships have been developed and integrated into a cost-performance model of the plant. The figure-of-merit for determining the most attractive design point is the constant-dollar cost of electricity. Results are presented as a function of the driver energy. The sensitivity of the results to variations in the assumed net electric output and target performance is also examined

  11. Experimental and Kinetic Modeling Study of Methanol Ignition and Oxidation at High Pressure

    DEFF Research Database (Denmark)

    Aranda, V.; Christensen, J. M.; Alzueta, Maria

    2013-01-01

    A detailed chemical kinetic model for oxidation of CH3OH at high pressure and intermediate temperatures has been developed and validated experimentally. Ab initio calculations and Rice–Ramsperger–Kassel–Marcus/transition state theory (RRKM/TST) analysis were used to obtain rate coefficients for CH...... the conditions studied, the onset temperature for methanol oxidation was not dependent on the stoichiometry, whereas increasing pressure shifted the ignition temperature toward lower values. Model predictions of the present experimental results, as well as rapid compression machine data from the literature, were...

  12. Economic modeling and parametric studies for OSIRIS - a HIB-driven IFE power plant

    International Nuclear Information System (INIS)

    Meier, W.R.; Bieri, R.L.

    1992-01-01

    Economic modeling and parametric studies for the Osiris HIB-driven inertial fusion energy (IFE) electric power plant have been conducted to determine the most attractive operating point. Cost scaling relationships have been developed and integrated into a cost-performance model of the plant. The figure-of-merit for determining the most attractive design point is the constant-dollar cost of electricity. Results are presented as a function of the driver energy. The sensitivity of the results to variations in the assumed net electric output and target performance is also examined

  13. Comparative Study of Bancruptcy Prediction Models

    Directory of Open Access Journals (Sweden)

    Isye Arieshanti

    2013-09-01

    Full Text Available Early indication of bancruptcy is important for a company. If companies aware of  potency of their bancruptcy, they can take a preventive action to anticipate the bancruptcy. In order to detect the potency of a bancruptcy, a company can utilize a a model of bancruptcy prediction. The prediction model can be built using a machine learning methods. However, the choice of machine learning methods should be performed carefully. Because the suitability of a model depends on the problem specifically. Therefore, in this paper we perform a comparative study of several machine leaning methods for bancruptcy prediction. According to the comparative study, the performance of several models that based on machine learning methods (k-NN, fuzzy k-NN, SVM, Bagging Nearest Neighbour SVM, Multilayer Perceptron(MLP, Hybrid of MLP + Multiple Linear Regression, it can be showed that fuzzy k-NN method achieve the best performance with accuracy 77.5%

  14. NOT JUST SHOP – An Innovative and Socially Responsible Business Model: The Case Study

    Directory of Open Access Journals (Sweden)

    Małgorzata Gotowska

    2016-06-01

    Full Text Available The article presents an example of a Europe-wide, innovative business model in the form of an I nternet store – NOT JUST SHOP. The examples of this business model can also be found in the United States. This is the first model of this sort in Europe. A similar business model is currently used in Switzerland. I ts objective is regular economic activity and seeking to make profit. This is nothing unusual. There are many companies like this. However, NOT JUST SHOP offers products the price of which includes an amount which goes to children, adults and other social groups in need. What is most important, the said amount is immediately available for the needy, not after achieving a profit. Moreover, customers of NOT JUST SHOP instantly see where their money goes and for which purpose. Consequently, there is full transparency. The presented case study is a guideline to create new innovative business solutions which lead not only to achieving profits, but also undertaking actions which are socially responsible.

  15. Spatial Temporal Modelling of Particulate Matter for Health Effects Studies

    Science.gov (United States)

    Hamm, N. A. S.

    2016-10-01

    Epidemiological studies of the health effects of air pollution require estimation of individual exposure. It is not possible to obtain measurements at all relevant locations so it is necessary to predict at these space-time locations, either on the basis of dispersion from emission sources or by interpolating observations. This study used data obtained from a low-cost sensor network of 32 air quality monitoring stations in the Dutch city of Eindhoven, which make up the ILM (innovative air (quality) measurement system). These stations currently provide PM10 and PM2.5 (particulate matter less than 10 and 2.5 m in diameter), aggregated to hourly means. The data provide an unprecedented level of spatial and temporal detail for a city of this size. Despite these benefits the time series of measurements is characterized by missing values and noisy values. In this paper a space-time analysis is presented that is based on a dynamic model for the temporal component and a Gaussian process geostatistical for the spatial component. Spatial-temporal variability was dominated by the temporal component, although the spatial variability was also substantial. The model delivered accurate predictions for both isolated missing values and 24-hour periods of missing values (RMSE = 1.4 μg m-3 and 1.8 μg m-3 respectively). Outliers could be detected by comparison to the 95% prediction interval. The model shows promise for predicting missing values, outlier detection and for mapping to support health impact studies.

  16. Hydropower recovery in water supply systems: Models and case study

    International Nuclear Information System (INIS)

    Vilanova, Mateus Ricardo Nogueira; Balestieri, José Antônio Perrella

    2014-01-01

    Highlights: • We present hydropower recovery models for water supply systems. • Hydropower recovery potential in water supply systems is highly variable. • The case studied could make the supply systems self-sufficient in terms of energy. • Hydropower recovery can reduce GHGs emissions and generate carbon credits. - Abstract: The energy efficiency of water supply systems can be increased through the recovery of hydraulic energy implicit to the volumes of water transported in various stages of the supply process, which can be converted into electricity through hydroelectric recovery systems. Such a process allows the use of a clean energy source that is usually neglected in water supplies, reducing its dependence on energy from the local network and the system’s operation costs. This article evaluates the possibilities and benefits of the use of water supply facilities, structures and equipment for hydraulic energy recovery, addressing several applicable hydroelectric models. A real case study was developed in Brazil to illustrate the technical, economic and environmental aspects of hydropower recovery in water supply systems

  17. Hydraulic modeling of flow impact on bridge structures: a case study on Citarum bridge

    Science.gov (United States)

    Siregar, R. I.

    2018-02-01

    Flood waves because of the rapid catchment response to high intense rainfall, breaches of flood defenses may induce huge impact forces on structures, causing structural damage or even failures. Overflowing stream that passes over the bridge, it means to discharge flood water level is smaller than the capacity of the river flow. In this study, the researches present the methodological approach of flood modeling on bridge structures. The amount of force that obtained because of the hydrostatic pressure received by the bridge at the time of the flood caused the bridge structure disrupted. This paper presents simulation of flow impact on bridge structures with some event flood conditions. Estimating the hydrostatic pressure developed new model components, to quantify the flow impact on structures. Flow parameters applied the model for analyzing, such as discharge, velocity, and water level or head that effect of bridge structures. The simulation will illustrate the capability of bridge structures with some event flood river and observe the behavior of the flow that occurred during the flood. Hydraulic flood modeling use HEC-RAS for simulation. This modeling will describe the impact on bridge structures. Based on the above modelling resulted, in 2008 has flood effect more than other years on the Citarum Bridge, because its flow overflow on the bridge.

  18. Geomagnetic field models for satellite angular motion studies

    Science.gov (United States)

    Ovchinnikov, M. Yu.; Penkov, V. I.; Roldugin, D. S.; Pichuzhkina, A. V.

    2018-03-01

    Four geomagnetic field models are discussed: IGRF, inclined, direct and simplified dipoles. Geomagnetic induction vector expressions are provided in different reference frames. Induction vector behavior is compared for different models. Models applicability for the analysis of satellite motion is studied from theoretical and engineering perspectives. Relevant satellite dynamics analysis cases using analytical and numerical techniques are provided. These cases demonstrate the benefit of a certain model for a specific dynamics study. Recommendations for models usage are summarized in the end.

  19. A Study on Development of a Cost Optimal and Energy Saving Building Model: Focused on Industrial Building

    Directory of Open Access Journals (Sweden)

    Hye Yeon Kim

    2016-03-01

    Full Text Available This study suggests an optimization method for the life cycle cost (LCC in an economic feasibility analysis when applying energy saving techniques in the early design stage of a building. Literature and previous studies were reviewed to select appropriate optimization and LCC analysis techniques. The energy simulation (Energy Plus and computational program (MATLAB were linked to provide an automated optimization process. From the results, it is suggested that this process could outline the cost optimization model with which it is possible to minimize the LCC. To aid in understanding the model, a case study on an industrial building was performed to outline the operations of the cost optimization model including energy savings. An energy optimization model was also presented to illustrate the need for the cost optimization model.

  20. Study on frugmentation of one-quasiparticle and one-phonon states in the quasiparticle-phonon nuclear model

    International Nuclear Information System (INIS)

    Solov'ev, V.G.

    1980-01-01

    The general assumptions of the quasiparticle-phonon nuclear model are given. This model describes the few-quasiparticle components of the wave functions at low, intermediate and high excitation energies. The method of strength functions which plays a key role in describing complex nuclei is also presented. A further development of the quasiparticle-phonon nuclear model is outlined. The fragmentation of one-quasiparticle and one-phonon states over nuclear levels is studied. The results on the fragmentation of deep hole states in spherical nuclei are presented, which describe well the experimental data. The neutron strength functions and their spin dependence are calculated. A good agreement with experiment is obtained. The energies and widths of the giant resonances are calculated in spherical and deformed nuclei. The information on the many-quasiparticle components of excited state wave functions is shown to be very scarce. The necessity of studying the few-quasiparticle configurations is pointed out