WorldWideScience

Sample records for model studies presented

  1. Lithium-Ion Battery Safety Study Using Multi-Physics Internal Short-Circuit Model (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Kim, G-.H.; Smith, K.; Pesaran, A.

    2009-06-01

    This presentation outlines NREL's multi-physics simulation study to characterize an internal short by linking and integrating electrochemical cell, electro-thermal, and abuse reaction kinetics models.

  2. ISOCT study of collagen crosslinking of collagen in cancer models (Conference Presentation)

    Science.gov (United States)

    Spicer, Graham; Young, Scott T.; Yi, Ji; Shea, Lonnie D.; Backman, Vadim

    2016-03-01

    The role of extracellular matrix modification and signaling in cancer progression is an increasingly recognized avenue for the progression of the disease. Previous study of field effect carcinogenesis with Inverse Spectroscopic Optical Coherence Tomography (ISOCT) has revealed pronounced changes in the nanoscale-sensitive mass fractal dimension D measured from field effect tissue when compared to healthy tissue. However, the origin of this difference in tissue ultrastructure in field effect carcinogenesis has remained poorly understood. Here, we present findings supporting the idea that enzymatic crosslinking of the extracellular matrix is an effect that presents at the earliest stages of carcinogenesis. We use a model of collagen gel with crosslinking induced by lysyl oxidase (LOXL4) to recapitulate the difference in D previously reported from healthy and cancerous tissue biopsies. Furthermore, STORM imaging of this collagen gel model verifies the morphologic effects of enzymatic crosslinking at length scales as small as 40 nm, close to the previously reported lower length scale sensitivity threshold of 35 nm for ISOCT. Analysis of the autocorrelation function from STORM images of collagen gels and subsequent fitting to the Whittle-Matérn correlation function shows a similar effect of LOXL4 on D from collagen measured with ISOCT and STORM. We extend this to mass spectrometric study of tissue to directly measure concentrations of collagen crosslink residues. The validation of ISOCT as a viable tool for non-invasive rapid quantification of collagen ultrastructure lends it to study other physiological phenomena involving ECM restructuring such as atherosclerotic plaque screening or cervical ripening during pregnancy.

  3. A model study of present-day Hall-effect circulators

    Energy Technology Data Exchange (ETDEWEB)

    Placke, B. [RWTH Aachen University, Institute for Quantum Information, Aachen (Germany); Bosco, S. [RWTH Aachen University, Institute for Quantum Information, Aachen (Germany); Juelich-Aachen Research Alliance (JARA), Fundamentals of Future Information Technologiesh, Juelich (Germany); DiVincenzo, D.P. [RWTH Aachen University, Institute for Quantum Information, Aachen (Germany); Juelich-Aachen Research Alliance (JARA), Fundamentals of Future Information Technologiesh, Juelich (Germany); Peter Gruenberg Institute, Theoretical Nanoelectronics, Forschungszentrum Juelich, Juelich (Germany)

    2017-12-15

    Stimulated by the recent implementation of a three-port Hall-effect microwave circulator of Mahoney et al. (MEA), we present model studies of the performance of this device. Our calculations are based on the capacitive-coupling model of Viola and DiVincenzo (VD). Based on conductance data from a typical Hall-bar device obtained from a two-dimensional electron gas (2DEG) in a magnetic field, we numerically solve the coupled field-circuit equations to calculate the expected performance of the circulator, as determined by the S parameters of the device when coupled to 50Ω ports, as a function of frequency and magnetic field. Above magnetic fields of 1.5 T, for which a typical 2DEG enters the quantum Hall regime (corresponding to a Landau-level filling fraction ν of 20), the Hall angle θ{sub H} = tan{sup -1} σ{sub xy}/σ{sub xx} always remains close to 90 , and the S parameters are close to the analytic predictions of VD for θ{sub H} = π/2. As anticipated by VD, MEA find the device to have rather high (kΩ) impedance, and thus to be extremely mismatched to 50Ω, requiring the use of impedance matching. We incorporate the lumped matching circuits of MEA in our modeling and confirm that they can produce excellent circulation, although confined to a very small bandwidth. We predict that this bandwidth is significantly improved by working at lower magnetic field when the Landau index is high, e.g. ν = 20, and the impedance mismatch is correspondingly less extreme. Our modeling also confirms the observation of MEA that parasitic port-to-port capacitance can produce very interesting countercirculation effects. (orig.)

  4. A model study of present-day Hall-effect circulators

    International Nuclear Information System (INIS)

    Placke, B.; Bosco, S.; DiVincenzo, D.P.

    2017-01-01

    Stimulated by the recent implementation of a three-port Hall-effect microwave circulator of Mahoney et al. (MEA), we present model studies of the performance of this device. Our calculations are based on the capacitive-coupling model of Viola and DiVincenzo (VD). Based on conductance data from a typical Hall-bar device obtained from a two-dimensional electron gas (2DEG) in a magnetic field, we numerically solve the coupled field-circuit equations to calculate the expected performance of the circulator, as determined by the S parameters of the device when coupled to 50Ω ports, as a function of frequency and magnetic field. Above magnetic fields of 1.5 T, for which a typical 2DEG enters the quantum Hall regime (corresponding to a Landau-level filling fraction ν of 20), the Hall angle θ_H = tan"-"1 σ_x_y/σ_x_x always remains close to 90 , and the S parameters are close to the analytic predictions of VD for θ_H = π/2. As anticipated by VD, MEA find the device to have rather high (kΩ) impedance, and thus to be extremely mismatched to 50Ω, requiring the use of impedance matching. We incorporate the lumped matching circuits of MEA in our modeling and confirm that they can produce excellent circulation, although confined to a very small bandwidth. We predict that this bandwidth is significantly improved by working at lower magnetic field when the Landau index is high, e.g. ν = 20, and the impedance mismatch is correspondingly less extreme. Our modeling also confirms the observation of MEA that parasitic port-to-port capacitance can produce very interesting countercirculation effects. (orig.)

  5. Geochemical modelling and speciation studies of metal pollutants present in selected water systems in South Africa

    Science.gov (United States)

    Magu, M. M.; Govender, P. P.; Ngila, J. C.

    2016-04-01

    Metal pollutants in water poses great threats to living beings and hence requires to be monitored regularly to avoid loss of lives. Various analytical methods are available to monitor these pollutants in water and can be improved with time. Modelling of metal pollutants in any water system helps chemists, engineers and environmentalists to greatly understand the various chemical processes in such systems. Water samples were collected from waste water treatment plant and river from highlands close to its source all the way to the ocean as it passing through areas with high anthropogenic activities. Pre-concentration of pollutants in the samples was done through acid digestion and metal pollutants were analysed using inductively coupled plasma-optical emission spectra (ICP-OES) to determine the concentration levels. Metal concentrations ranged between 0.1356-0.4658 mg/L for Al; 0.0031-0.0050 mg/L for Co, 0.0019-0.0956 mg/L for Cr; 0.0028-0.3484 mg/L for Cu; 0.0489-0.3474 mg/L for Fe; 0.0033-0.0285 mg/L for Mn; 0.0056-0.0222 mg/L for Ni; 0.0265-0.4753 mg/L for Pb and 0.0052-0.5594 mg/L for Zn. Modelling work was performed using PHREEQC couple with Geochemist's workbench (GWB) to determine speciation dynamics and bioavailability of these pollutants. Modelling thus adds value to analytical methods and hence a better complementary tool to laboratory-based experimental studies.

  6. The chlorine budget of the present-day atmosphere - A modeling study

    Science.gov (United States)

    Weisenstein, Debra K.; Ko, Malcolm K. W.; Sze, Nien-Dak

    1992-01-01

    The contribution of source gases to the total amount of inorganic chlorine (ClY) is examined analytically with a time-dependent model employing 11 source gases. The source-gas emission data are described, and the modeling methodology is set forth with attention given to the data interpretation. The abundances and distributions are obtained for all 11 source gases with corresponding ClY production rates and mixing ratios. It is shown that the ClY production rate and the ClY mixing ratio for each source gas are spatially dependent, and the change in the relative contributions from 1950 to 1990 is given. Ozone changes in the past decade are characterized by losses in the polar and midlatitude lower stratosphere. The values for CFC-11, CCl4, and CH3CCl3 suggest that they are more evident in the lower stratosphere than is suggested by steady-state estimates based on surface concentrations.

  7. Presenting Enterprise Architecture Strategies Using Business Model Canvas (Case Study of E-commerce PT Xyz)

    OpenAIRE

    Christini, Chintamy; Rahmad, Basuki

    2015-01-01

    Information Technology (IT) is known as enabler of business. One of the study that align business and IT is enterprise architecture. In this era, one of the business that become a trend the world is electronic commerce (e-commerce). With the suitable enterprise architecture strategies, e-commerce can be improved according to the business and IT condition. This paper represents about study case of an Indonesian e-commerce website which is still unknown by internet users and the SWOT strategy a...

  8. Analyzing musculoskeletal neck pain, measured as present pain and periods of pain, with three different regression models: a cohort study

    Directory of Open Access Journals (Sweden)

    Hagberg Mats

    2009-06-01

    Full Text Available Abstract Background In the literature there are discussions on the choice of outcome and the need for more longitudinal studies of musculoskeletal disorders. The general aim of this longitudinal study was to analyze musculoskeletal neck pain, in a group of young adults. Specific aims were to determine whether psychosocial factors, computer use, high work/study demands, and lifestyle are long-term or short-term factors for musculoskeletal neck pain, and whether these factors are important for developing or ongoing musculoskeletal neck pain. Methods Three regression models were used to analyze the different outcomes. Pain at present was analyzed with a marginal logistic model, for number of years with pain a Poisson regression model was used and for developing and ongoing pain a logistic model was used. Presented results are odds ratios and proportion ratios (logistic models and rate ratios (Poisson model. The material consisted of web-based questionnaires answered by 1204 Swedish university students from a prospective cohort recruited in 2002. Results Perceived stress was a risk factor for pain at present (PR = 1.6, for developing pain (PR = 1.7 and for number of years with pain (RR = 1.3. High work/study demands was associated with pain at present (PR = 1.6; and with number of years with pain when the demands negatively affect home life (RR = 1.3. Computer use pattern (number of times/week with a computer session ≥ 4 h, without break was a risk factor for developing pain (PR = 1.7, but also associated with pain at present (PR = 1.4 and number of years with pain (RR = 1.2. Among life style factors smoking (PR = 1.8 was found to be associated to pain at present. The difference between men and women in prevalence of musculoskeletal pain was confirmed in this study. It was smallest for the outcome ongoing pain (PR = 1.4 compared to pain at present (PR = 2.4 and developing pain (PR = 2.5. Conclusion By using different regression models different

  9. Explanatory models and distress in primary caregivers of patients with acute psychotic presentations: A study from South India.

    Science.gov (United States)

    Joy, Deepa S; Manoranjitham, S D; Samuel, P; Jacob, K S

    2017-11-01

    Emotional distress among caregivers of people with mental illness is common, changes overtime and requires appropriate coping strategies to prevent long-term disability. Explanatory models, which underpin understanding of disease and illness, are crucial to coping. To study the association of explanatory models and distress among caregivers of people with acute psychotic illness. A total of 60 consecutive patients and their primary caregivers who presented to the Department of Psychiatry, Christian Medical College, Vellore, were recruited for the study. Positive and Negative Syndrome Scale (PANSS), Short Explanatory Model Interview (SEMI) and the General Health Questionnaire-12 (GHQ-12) were used to assess severity of psychosis, explanatory models of illness and emotional distress. Standard bivariate and multivariable statistics were employed. Majority of the caregivers simultaneously held multiple models of illness, which included medical and non-medical perspectives. The GHQ-12 score were significantly lower in people who held multiple explanatory models of illness when compared to the caregivers who believed single explanations. Explanatory models affect coping in caregivers of patients with acute psychotic presentations. There is a need to have a broad-based approach to recovery and care.

  10. HYDROGEOLOGIC CASE STUDIES (DENVER PRESENTATION)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  11. Presentation of a Novel Model for Evaluation of Commercialization of Research and Development: Case Study of the Pharmaceutical Biotechnology Industry.

    Science.gov (United States)

    Emami, Hassan; Radfar, Reza

    2017-01-01

    The current situation in Iran suggests an appropriate basis for developing biotechnology industries, because the patents for the majority of hi-tech medicines registered in developed countries are ending. Biosimilar and technology-oriented companies which do not have patents will have the opportunity to enter the biosimilar market and move toward innovative initiatives. The present research proposed a model by which one can evaluate commercialization of achievements obtained from research with a focus on the pharmaceutical biotechnology industry. This is a descriptive-analytic study where mixed methodology is followed by a heuristic approach. The statistical population was pharmaceutical biotechnology experts at universities and research centers in Iran. Structural equations were employed in this research. The results indicate that there are three effective layers within commercialization in the proposed model. These are a general layer (factors associated with management, human capital, legal infrastructure, communication infrastructure, a technical and executive infrastructures, and financial factors), industrial layer (internal industrial factors and pharmaceutical industry factors), and a third layer that included national and international aspects. These layers comprise 6 domains, 21 indices, 41 dimensions, and 126 components. Compilation of these layers (general layer, industrial layer, and national and international aspects) can serve commercialization of research and development as an effective evaluation package.

  12. Presenting a practical model for governmental political mapping on road traffic injuries in Iran in 2008: a qualitative study.

    Science.gov (United States)

    Ainy, E; Soori, Hamid; Mahfozphoor, S; Movahedinejad, Aa

    2011-10-01

    This study was conducted to assess political mapping in relation to road traffic injuries (RTIs) management and prevention to present a practical model for RTIs. A phenomenological qualitative study was developed to identify stakeholders on RTI in Iran in 2008. The designed questions were discussed by systematic discussion with the relevant specialists. After receiving written consent from the main responsible stakeholders, the questionnaire was filled in by trained experts. Themes were determined and content was analysed in each part. Main responsible stakeholders. By comparing other countries' political mappings which were found in the library and by Internet searching, political mapping of RTI in Iran was suggested. Subjects were 26 experts from governmental and non-governmental organizations. The main proposed leading agencies were traffic police and presidency (13% each). Findings showed that only 31% of our political mapping was formed according to the World Health Organization (WHO). In 94% of cases, the involved organizations had unspecified roles; the reason was poor monitoring for RTI in 39% of organizations. Lack of adequate authority and suitable legislation, appropriate laws and tasks definition were 94% and 18%, respectively. The most essential policy to overcome problems was defined as appropriate legislation (21%), and the most frequent type of support needed was mentioned as adequate budgeting (25%). Traffic police can play the leading agency role by government support, with strong leadership, appropriate legislation, defined tasks and adequate budget.

  13. Economic burden of torture for a refugee host country: development of a model and presentation of a country case study

    Directory of Open Access Journals (Sweden)

    Mpinga EK

    2014-04-01

    Full Text Available Emmanuel Kabengele Mpinga,1,* Conrad Frey,2,* Philippe Chastonay1,*1Institute of Social and Preventive Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland; 2Psychiatric Clinic, Obwalden Cantonal Hospital, Sarnen, Switzerland*These authors contributed equally to this workBackground: Torture is an important social and political problem worldwide that affects millions of people. Many host countries give victims of torture the status of refugee and take care of them as far as basic needs; health care, professional reinsertion, and education. Little is known about the costs of torture. However, this knowledge could serve as an additional argument for the prevention and social mobilization to fight against torture and to provide a powerful basis of advocacy for rehabilitation programs and judiciary claims.Objectives: Development of a model for estimating the economic costs of torture and applying the model to a specific country.Methods: The estimation of the possible prevalence of victims of torture was based on a review of the literature. The identification of the socioeconomic factors to be considered was done by analogy with various health problems. The estimation of the loss of the productivity and of the economic burden of disease related to torture was done through the human capital approach and the component technique analysis.Case study: The model was applied to the situation in Switzerland of estimated torture victims Switzerland is confronted with.Results: When applied to the case study, the direct costs – such as housing, food, and clothing – represent roughly 130 million Swiss francs (CHF per year; whereas, health care costs amount to 16 million CHF per year, and the costs related to education of young people to 34 million CHF per year. Indirect costs, namely those costs related to the loss of the productivity of direct survivors of torture, have been estimated to one-third of 1 billion CHF per year. This jumps to

  14. Presenting "recious Knowledge": Using Film to Model Culturally Sustaining Pedagogy and Youth Civic Activism for Social Studies Teachers

    Science.gov (United States)

    Parkhouse, Hillary

    2015-01-01

    In this article, I examine the potential for developing preservice social studies teachers' understanding of transformational resistance, Latin@ civil rights movements, and culturally sustaining pedagogy through a project using the film Precious Knowledge. This documentary depicts high school students in a Mexican American Studies (MAS) program…

  15. Fuel model studies. Comparison of our present version of GAPCON-THERMAL-2 with results from the EPRI code comparison study. Partial report

    International Nuclear Information System (INIS)

    Malen, K.; Jansson, L.

    1978-08-01

    Runs with our present version of GAPCON-THERMAL-2 have been compared to results from the EPRI code comparison study. Usually also our version of GAPCON predicts high temperatures, 100-300 K or 10-15% higher than average code predictions and experimental results. The well-known temperaturegas release instablility is found also with GAPCON. In this case one identifies the gas release limits 1400 deg C and 1700 deg C as instablility points. (author)

  16. Hydrological catchment modelling: past, present and future

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available This paper discusses basic issues in hydrological modelling and flood forecasting, ranging from the roles of physically-based and data-driven rainfall runoff models, to the concepts of predictive uncertainty and equifinality and their implications. The evolution of a wide range of hydrological catchment models employing the physically meaningful and data-driven approaches introduces the need for objective test beds or benchmarks to assess the merits of the different models in reconciling the alternative approaches. In addition, the paper analyses uncertainty in models and predictions by clarifying the meaning of uncertainty, by distinguishing between parameter and predictive uncertainty and by demonstrating how the concept of equifinality must be addressed by appropriate and robust inference approaches. Finally, the importance of predictive uncertainty in the decision making process is highlighted together with possible approaches aimed at overcoming the diffidence of end-users.

  17. PREGO (presentation of Graves' orbitopathy) study

    DEFF Research Database (Denmark)

    Perros, Petros; Žarković, Miloš; Azzolini, Claudio

    2015-01-01

    BACKGROUND/AIMS: The epidemiology of Graves' orbitopathy (GO) may be changing. The aim of the study was to identify trends in presentation of GO to tertiary centres and initial management over time. METHODS: Prospective observational study of European Group On Graves' Orbitopathy (EUGOGO) centres...

  18. Presentation

    Directory of Open Access Journals (Sweden)

    Eduardo Vicente

    2013-06-01

    effectivities more than a number of fixed essential characteristics. Luiz Artur Ferrareto (UFRGS, undertaking a theoretical proposal for categorizing radio content in four different levels of planning (segment, form, programming and content itself tries to “compare and contrast the practices of Brazilian commercial broadcasting companies to those used on the radio in the United States, a reference market for our national entrepreneurs”. Madalena Oliveira (University of Minho focuses on the current stage of communication researches in Portugal reflecting on the challenges for studying a culture based on listening in times of looking. Marko Ala-Fossi, (University of Tampere beginning with the statement that “radio evolution greatly depends not only on the cultural context of a country but also on the whole social, political, economic development of societies” gives us a projection on radio development around the world for the next decades. Closing the dossier, Rafael Duarte Oliveira Venancio (UFU assuming radio as language by definition and not as a device understands it as a section and an operating model in such language as it intersects the world. Another six articles, not enrolled in the dossier, round the edition off. Fernando de Tacca debates the category of “photocine” recurring to three recent Spanish productions. Gustavo Souza investigates the possibility of identifying a point of view in documentary movies while establishing a debate that joins the materialities of image and sound with the subjectivity resulting from interpretation. Vinicius Bandeira develops on the special duplicity present in the movies between what is and what is not subsumed by the camera. Neide Jallageas proposes the study of visual communication design from the first modelings, attempting especially to the radical propositions from the early XXth century avant-garde movement. Gilson Schwartz debates on the impact from the distribution of videogames as hegemonic cultural practice in

  19. Presenting an Evaluation Model for the Cancer Registry Software.

    Science.gov (United States)

    Moghaddasi, Hamid; Asadi, Farkhondeh; Rabiei, Reza; Rahimi, Farough; Shahbodaghi, Reihaneh

    2017-12-01

    As cancer is increasingly growing, cancer registry is of great importance as the main core of cancer control programs, and many different software has been designed for this purpose. Therefore, establishing a comprehensive evaluation model is essential to evaluate and compare a wide range of such software. In this study, the criteria of the cancer registry software have been determined by studying the documents and two functional software of this field. The evaluation tool was a checklist and in order to validate the model, this checklist was presented to experts in the form of a questionnaire. To analyze the results of validation, an agreed coefficient of %75 was determined in order to apply changes. Finally, when the model was approved, the final version of the evaluation model for the cancer registry software was presented. The evaluation model of this study contains tool and method of evaluation. The evaluation tool is a checklist including the general and specific criteria of the cancer registry software along with their sub-criteria. The evaluation method of this study was chosen as a criteria-based evaluation method based on the findings. The model of this study encompasses various dimensions of cancer registry software and a proper method for evaluating it. The strong point of this evaluation model is the separation between general criteria and the specific ones, while trying to fulfill the comprehensiveness of the criteria. Since this model has been validated, it can be used as a standard to evaluate the cancer registry software.

  20. Presenting an evaluation model of the trauma registry software.

    Science.gov (United States)

    Asadi, Farkhondeh; Paydar, Somayeh

    2018-04-01

    Trauma is a major cause of 10% death in the worldwide and is considered as a global concern. This problem has made healthcare policy makers and managers to adopt a basic strategy in this context. Trauma registry has an important and basic role in decreasing the mortality and the disabilities due to injuries resulted from trauma. Today, different software are designed for trauma registry. Evaluation of this software improves management, increases efficiency and effectiveness of these systems. Therefore, the aim of this study is to present an evaluation model for trauma registry software. The present study is an applied research. In this study, general and specific criteria of trauma registry software were identified by reviewing literature including books, articles, scientific documents, valid websites and related software in this domain. According to general and specific criteria and related software, a model for evaluating trauma registry software was proposed. Based on the proposed model, a checklist designed and its validity and reliability evaluated. Mentioned model by using of the Delphi technique presented to 12 experts and specialists. To analyze the results, an agreed coefficient of %75 was determined in order to apply changes. Finally, when the model was approved by the experts and professionals, the final version of the evaluation model for the trauma registry software was presented. For evaluating of criteria of trauma registry software, two groups were presented: 1- General criteria, 2- Specific criteria. General criteria of trauma registry software were classified into four main categories including: 1- usability, 2- security, 3- maintainability, and 4-interoperability. Specific criteria were divided into four main categories including: 1- data submission and entry, 2- reporting, 3- quality control, 4- decision and research support. The presented model in this research has introduced important general and specific criteria of trauma registry software

  1. Present studies on the radiosterilized drugs

    International Nuclear Information System (INIS)

    Marciniec, B.; Dettlaff, K.

    2007-01-01

    Lecture presents present status of radiosterilization of drugs and medical materials as compared to other sterilization methods. Literature review is shown on degradation of different kinds of drugs sterilized upon action of the sterilising doses of radiation

  2. Presentations

    International Nuclear Information System (INIS)

    2007-01-01

    The presented materials consist of presentations of international workshop which held in Warsaw from 4 to 5 October 2007. Main subject of the meeting was progress in manufacturing as well as research program development for neutron detector which is planned to be placed at GANIL laboratory and will be used in nuclear spectroscopy research

  3. Development of Presentation Model with Cloud Based Infrastructure

    Directory of Open Access Journals (Sweden)

    Magdalena Widiantari Maria

    2018-01-01

    Full Text Available Computer mediated communication are the communication activities using technology which have rapidly in progress. Communication interactive activities nowadays has no longer only involving person to person but mediated by technology, and have been done in many fields including in education and teaching activity. In this study, presentation media based on cloud's infrastructure designed to replace face to face or in class lectures. In addition, the presentation will allow media data storage indefinitely, and accessible wherever and anytime. This is in line with the concept of student center learning where students were encouraged to more active in the lecture activities. The purpose of this research is making or designing a presentation model based on cloud‘s infrastructure. This research is using research and development method which is consists of four stages, where the first phase is composing the concept of media presentation design. The second phase are choosing the subject that will be designed as the subject of presentation. The third stage is designing presentation model. And the fourth phase is collecting materials of the subject that will be presented by each lecturer.

  4. Nuclear model developments in FLUKA for present and future applications

    Science.gov (United States)

    Cerutti, Francesco; Empl, Anton; Fedynitch, Anatoli; Ferrari, Alfredo; Ruben, GarciaAlia; Sala, Paola R.; Smirnov, George; Vlachoudis, Vasilis

    2017-09-01

    The FLUKAS code [1-3] is used in research laboratories all around the world for challenging applications spanning a very wide range of energies, projectiles and targets. FLUKAS is also extensively used for in hadrontherapy research studies and clinical planning systems. In this paper some of the recent developments in the FLUKAS nuclear physics models of relevance for very different application fields including medical physics are presented. A few examples are shown demonstrating the effectiveness of the upgraded code.

  5. Presenting Software Metrics Indicators- A Case Study

    DEFF Research Database (Denmark)

    Pantazos, Kostas; Shollo, Arisa; Staron, Miroslaw

    2010-01-01

    Industrial measurement systems in software projects can generate a large number of indicators (main measurements). Having a large number of indicators might result in failing to present an overview of the status of measured entities. In consequence, managers might experience problems when making...

  6. Presentations

    International Nuclear Information System (INIS)

    2007-01-01

    The PARIS meeting held in Cracow, Poland from 14 to 15 May 2007. The main subjects discussed during this meeting were the status of international project dedicated to gamma spectroscopy research. The scientific research program includes investigations of giant dipole resonance, probe of hot nuclei induced in heavy reactions, Jacobi shape transitions, isospin mixing and nuclear multifragmentation. The mentioned programme needs Rand D development such as new scintillations materials as lanthanum chlorides and bromides as well as new photo detection sensors as avalanche photodiodes - such subjects are also subjects of discussion. Additionally results of computerized simulations of scintillation detectors properties by means of GEANT- 4 code are presented

  7. The study of emotional presentation after stroke

    Institute of Scientific and Technical Information of China (English)

    Qijia Shi; Donghang Li

    2000-01-01

    Abstract: 30 stroke cases were studied in field of their emotional facts. linear related statistics showed the negative relation between the age, disease onset MMSE and ADL with SDS, SSRI drugs and Psychothcrapy should bc useful for prohibiting sever functional retardation.

  8. Urban phenological studies – Past, present, future

    International Nuclear Information System (INIS)

    Jochner, Susanne; Menzel, Annette

    2015-01-01

    Phenology is believed to be a suitable bio-indicator to track climate change. Based on the strong statistical association between phenology and temperature phenological observations provide an inexpensive means for the temporal and spatial analysis of the urban heat island. However, other environmental factors might also weaken this relationship. In addition, the investigation of urban phenology allows an estimation of future phenology from current information since cities with their amplified temperatures may serve as a proxy for future conditions. Nevertheless, the design of spatial compared to long-term studies might be influenced by different factors which should be taken into consideration when interpreting results from a specific study. In general, plants located in urban areas tend to flush and bloom earlier than in the countryside. What are the consequences of these urban–rural differences? This review will document existing findings on urban phenology and will highlight areas in which further research is needed. - Highlights: • Urban phenology can be used for the estimation of the urban heat island effect. • Confounding factors weaken the phenology–temperature relationship. • Urban phenology is useful as a proxy for climate change impacts on phenology. • Differences in the study design hinder the generalisation of one specific method. • Urban–rural variations in phenology affect vegetation, meteorology, human health. - Studies on urban phenology can be used to detect urban heat islands and to assess climate change impacts but it still remains important to adequately link spatial and long-term data

  9. present

    African Journals Online (AJOL)

    as medium of instruction enhances concept formation, especially in science subjects as ... The study, on which this paper is based, was conducted to evaluate Malawi's ... corrected in the wake of information flowing from the evaluation phase (Kaplan .... concerning the background information and suggested activities (Thodi,.

  10. PRESENTATION

    OpenAIRE

    Editors, The

    2017-01-01

    To plan and to implement academic projects remain a systematic challenge for the team and the collaborators of the Electronic Journal. Each study published is an opportunity to strengthen the proposed goals and to add more value to the community involved and interested.

  11. Heat Pump Water Heater Modeling in EnergyPlus (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, E.; Christensen, C.

    2012-03-01

    This presentation summarizes NREL's development of a HPWH model for use in hourly building energy simulation programs, such as BEopt; this presentation was given at the Building America Stakeholder meeting on March 1, 2012, in Austin, Texas.

  12. Building models for marketing decisions : Past, present and future

    NARCIS (Netherlands)

    Leeflang, PSH; Wittink, DR

    We review five eras of model building in marketing, with special emphasis on the fourth and the fifth eras, the present and the future. At many firms managers now routinely use model-based results for marketing decisions. Given an increasing number of successful applications, the demand for models

  13. Modeling population exposures to silver nanoparticles present in consumer products

    Science.gov (United States)

    Royce, Steven G.; Mukherjee, Dwaipayan; Cai, Ting; Xu, Shu S.; Alexander, Jocelyn A.; Mi, Zhongyuan; Calderon, Leonardo; Mainelis, Gediminas; Lee, KiBum; Lioy, Paul J.; Tetley, Teresa D.; Chung, Kian Fan; Zhang, Junfeng; Georgopoulos, Panos G.

    2014-11-01

    Exposures of the general population to manufactured nanoparticles (MNPs) are expected to keep rising due to increasing use of MNPs in common consumer products (PEN 2014). The present study focuses on characterizing ambient and indoor population exposures to silver MNPs (nAg). For situations where detailed, case-specific exposure-related data are not available, as in the present study, a novel tiered modeling system, Prioritization/Ranking of Toxic Exposures with GIS (geographic information system) Extension (PRoTEGE), has been developed: it employs a product life cycle analysis (LCA) approach coupled with basic human life stage analysis (LSA) to characterize potential exposures to chemicals of current and emerging concern. The PRoTEGE system has been implemented for ambient and indoor environments, utilizing available MNP production, usage, and properties databases, along with laboratory measurements of potential personal exposures from consumer spray products containing nAg. Modeling of environmental and microenvironmental levels of MNPs employs probabilistic material flow analysis combined with product LCA to account for releases during manufacturing, transport, usage, disposal, etc. Human exposure and dose characterization further employ screening microenvironmental modeling and intake fraction methods combined with LSA for potentially exposed populations, to assess differences associated with gender, age, and demographics. Population distributions of intakes, estimated using the PRoTEGE framework, are consistent with published individual-based intake estimates, demonstrating that PRoTEGE is capable of capturing realistic exposure scenarios for the US population. Distributions of intakes are also used to calculate biologically relevant population distributions of uptakes and target tissue doses through human airway dosimetry modeling that takes into account product MNP size distributions and age-relevant physiological parameters.

  14. Methodology for geometric modelling. Presentation and administration of site descriptive models; Metodik foer geometrisk modellering. Presentation och administration av platsbeskrivande modeller

    Energy Technology Data Exchange (ETDEWEB)

    Munier, Raymond [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Hermanson, Jan [Golder Associates (Sweden)

    2001-03-01

    This report presents a methodology to construct, visualise and present geoscientific descriptive models based on data from the site investigations, which the SKB currently performs, to build an underground nuclear waste disposal facility in Sweden. It is designed for interaction with SICADA (SKB:s site characterisation database) and RVS (SKB:s Rock Visualisation System). However, the concepts of the methodology are general and can be used with other tools capable of handling 3D geometries and parameters. The descriptive model is intended to be an instrument where site investigation data from all disciplines are put together to form a comprehensive visual interpretation of the studied rock mass. The methodology has four main components: 1. Construction of a geometrical model of the interpreted main structures at the site. 2. Description of the geoscientific characteristics of the structures. 3. Description and geometrical implementation of the geometric uncertainties in the interpreted model structures. 4. Quality system for the handling of the geometrical model, its associated database and some aspects of the technical auditing. The geometrical model forms a basis for understanding the main elements and structures of the investigated site. Once the interpreted geometries are in place in the model, the system allows for adding descriptive and quantitative data to each modelled object through a system of intuitive menus. The associated database allows each geometrical object a complete quantitative description of all geoscientific disciplines, variabilities, uncertainties in interpretation and full version history. The complete geometrical model and its associated database of object descriptions are to be recorded in a central quality system. Official, new and old versions of the model are administered centrally in order to have complete quality assurance of each step in the interpretation process. The descriptive model is a cornerstone in the understanding of the

  15. Presenting of Indifference Management Model of Education System in Ardabil Province Using Structural Equation Modeling

    Science.gov (United States)

    Abolfazli, Elham; Saidabadi, Reza Yousefi; Fallah, Vahid

    2016-01-01

    The purpose of the present study is to investigate indifference management structural model in education system of Ardabil Province. The research method was integration study using Alli modeling. Statistical society of research was 420 assistant professors of educational science, managers, and deputies of Ardabil's second period of high schools…

  16. Modeling of present and Eemian stable water isotopes in precipitation

    DEFF Research Database (Denmark)

    Sjolte, Jesper

    The subject of this thesis is the modeling of the isotopic temperature proxies d18O, dD and deuterium excess in precipitation. Two modeling studies were carried out, one using the regional climate model, and one using a global climate model. In the regional study the model was run for the period ...... the modeled isotopes do not agree with ice core data. The discrepancy between the model output and the ice core data is attributed to the boundary conditions, where changes in ice sheets and vegetation have not been accounted for.......The subject of this thesis is the modeling of the isotopic temperature proxies d18O, dD and deuterium excess in precipitation. Two modeling studies were carried out, one using the regional climate model, and one using a global climate model. In the regional study the model was run for the period...... 1959 to 2001 using meteorological data and a domain including Greenland and the surrounding North Atlantic. The model was found to reproduce the observed seasonal variability of temperature and precipitation well. In comparison with ice core data from Greenland and observations from coastal stations...

  17. Presenting a Model for Setting in Narrative Fiction Illustration

    Directory of Open Access Journals (Sweden)

    Hajar Salimi Namin

    2017-12-01

    Full Text Available The present research aims at presenting a model for evaluating and enhancing training the setting in illustration for narrative fictions for undergraduate students of graphic design who are weak in setting. The research utilized expert’s opinions through a survey. The designed model was submitted to eight experts, and their opinions were used to have the model adjusted and improved. Used as research instruments were notes, materials in text books, papers, and related websites, as well as questionnaires. Results indicated that, for evaluating and enhancing the level of training the setting in illustration for narrative fiction to students, one needs to extract sub-indexes of setting. Moreover, definition and recognition of the model of setting helps undergraduate students of graphic design enhance the level of setting in their works skill by recognizing details of setting. Accordingly, it is recommended to design training packages to enhance these sub-indexes and hence improve the setting for narrative fiction illustration.

  18. Possibilistic Fuzzy Net Present Value Model and Application

    Directory of Open Access Journals (Sweden)

    S. S. Appadoo

    2014-01-01

    Full Text Available The cash flow values and the interest rate in the net present value (NPV model are usually specified by either crisp numbers or random variables. In this paper, we first discuss some of the recent developments in possibility theory and find closed form expressions for fuzzy possibilistic net present value (FNPV. Then, following Carlsson and Fullér (2001, we discuss some of the possibilistic moments related to FNPV model along with an illustrative numerical example. We also give a unified approach to find higher order moments of FNPV by using the moment generating function introduced by Paseka et al. (2011.

  19. Numerical modelling of present and future hydrology at Laxemar- Simpevarp

    International Nuclear Information System (INIS)

    Sassner, Mona; Sabel, Ulrika; Bosson, Emma; Berglund, Sten

    2011-04-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) has performed site investigations at two potential sites for a final repository for spent nuclear fuel. This report presents results of water flow modelling of the Laxemar area. The modelling reported in this document is focused on the near-surface groundwater, i.e. groundwater in Quaternary deposits and shallow rock, and surface water systems, and was performed using the MIKE SHE tool. The main objective of the modelling was to provide input to the radionuclide transport and dose calculations that were carried out as a part of the comparison between the Laxemar and Forsmark sites

  20. Numerical modelling of present and future hydrology at Laxemar- Simpevarp

    Energy Technology Data Exchange (ETDEWEB)

    Sassner, Mona; Sabel, Ulrika (DHI Sverige AB (Sweden)); Bosson, Emma; Berglund, Sten (Svensk Kaernbraenslehantering AB (Sweden))

    2011-04-15

    The Swedish Nuclear Fuel and Waste Management Company (SKB) has performed site investigations at two potential sites for a final repository for spent nuclear fuel. This report presents results of water flow modelling of the Laxemar area. The modelling reported in this document is focused on the near-surface groundwater, i.e. groundwater in Quaternary deposits and shallow rock, and surface water systems, and was performed using the MIKE SHE tool. The main objective of the modelling was to provide input to the radionuclide transport and dose calculations that were carried out as a part of the comparison between the Laxemar and Forsmark sites

  1. Predictive Models of Li-ion Battery Lifetime (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G.; Shi, Y.; Pesaran, A.

    2014-09-01

    Predictive models of Li-ion battery reliability must consider a multiplicity of electrochemical, thermal and mechanical degradation modes experienced by batteries in application environments. Complicating matters, Li-ion batteries can experience several path dependent degradation trajectories dependent on storage and cycling history of the application environment. Rates of degradation are controlled by factors such as temperature history, electrochemical operating window, and charge/discharge rate. Lacking accurate models and tests, lifetime uncertainty must be absorbed by overdesign and warranty costs. Degradation models are needed that predict lifetime more accurately and with less test data. Models should also provide engineering feedback for next generation battery designs. This presentation reviews both multi-dimensional physical models and simpler, lumped surrogate models of battery electrochemical and mechanical degradation. Models are compared with cell- and pack-level aging data from commercial Li-ion chemistries. The analysis elucidates the relative importance of electrochemical and mechanical stress-induced degradation mechanisms in real-world operating environments. Opportunities for extending the lifetime of commercial battery systems are explored.

  2. Modelling and simulation-based acquisition decision support: present & future

    CSIR Research Space (South Africa)

    Naidoo, S

    2009-10-01

    Full Text Available stream_source_info Naidoo1_2009.pdf.txt stream_content_type text/plain stream_size 24551 Content-Encoding UTF-8 stream_name Naidoo1_2009.pdf.txt Content-Type text/plain; charset=UTF-8 1 Modelling & Simulation...-Based Acquisition Decision Support: Present & Future Shahen Naidoo Abstract The Ground Based Air Defence System (GBADS) Programme, of the South African Army has been applying modelling and simulation (M&S) to provide acquisition decision and doctrine...

  3. Statistical Model of the 2001 Czech Census for Interactive Presentation

    Czech Academy of Sciences Publication Activity Database

    Grim, Jiří; Hora, Jan; Boček, Pavel; Somol, Petr; Pudil, Pavel

    Vol. 26, č. 4 (2010), s. 1-23 ISSN 0282-423X R&D Projects: GA ČR GA102/07/1594; GA MŠk 1M0572 Grant - others:GA MŠk(CZ) 2C06019 Institutional research plan: CEZ:AV0Z10750506 Keywords : Interactive statistical model * census data presentation * distribution mixtures * data modeling * EM algorithm * incomplete data * data reproduction accuracy * data mining Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.492, year: 2010 http://library.utia.cas.cz/separaty/2010/RO/grim-0350513.pdf

  4. Past and present of sediment and carbon biogeochemical cycling models

    Directory of Open Access Journals (Sweden)

    F. T. Mackenzie

    2004-01-01

    Full Text Available The global carbon cycle is part of the much more extensive sedimentary cycle that involves large masses of carbon in the Earth's inner and outer spheres. Studies of the carbon cycle generally followed a progression in knowledge of the natural biological, then chemical, and finally geological processes involved, culminating in a more or less integrated picture of the biogeochemical carbon cycle by the 1920s. However, knowledge of the ocean's carbon cycle behavior has only within the last few decades progressed to a stage where meaningful discussion of carbon processes on an annual to millennial time scale can take place. In geologically older and pre-industrial time, the ocean was generally a net source of CO2 emissions to the atmosphere owing to the mineralization of land-derived organic matter in addition to that produced in situ and to the process of CaCO3 precipitation. Due to rising atmospheric CO2 concentrations because of fossil fuel combustion and land use changes, the direction of the air-sea CO2 flux has reversed, leading to the ocean as a whole being a net sink of anthropogenic CO2. The present thickness of the surface ocean layer, where part of the anthropogenic CO2 emissions are stored, is estimated as of the order of a few hundred meters. The oceanic coastal zone net air-sea CO2 exchange flux has also probably changed during industrial time. Model projections indicate that in pre-industrial times, the coastal zone may have been net heterotrophic, releasing CO2 to the atmosphere from the imbalance between gross photosynthesis and total respiration. This, coupled with extensive CaCO3 precipitation in coastal zone environments, led to a net flux of CO2 out of the system. During industrial time the coastal zone ocean has tended to reverse its trophic status toward a non-steady state situation of net autotrophy, resulting in net uptake of anthropogenic CO2 and storage of carbon in the coastal ocean, despite the significant calcification

  5. Surviving the present: Modeling tools for organizational change

    International Nuclear Information System (INIS)

    Pangaro, P.

    1992-01-01

    The nuclear industry, like the rest of modern American business, is beset by a confluence of economic, technological, competitive, regulatory, and political pressures. For better or worse, business schools and management consultants have leapt to the rescue, offering the most modern conveniences that they can purvey. Recent advances in the study of organizations have led to new tools for their analysis, revision, and repair. There are two complementary tools that do not impose values or injunctions in themselves. One, called the organization modeler, captures the hierarchy of purposes that organizations and their subparts carry out. Any deficiency or pathology is quickly illuminated, and requirements for repair are made clear. The second, called THOUGHTSTICKER, is used to capture the semantic content of the conversations that occur across the interactions of parts of an organization. The distinctions and vocabulary in the language of an organization, and the relations within that domain, are elicited from the participants so that all three are available for debate and refinement. The product of the applications of these modeling tools is not the resulting models but rather the enhancement of the organization as a consequence of the process of constructing them

  6. PRESENT STATUS OF RESEARCH IN DEBRIS FLOW MODELING.

    Science.gov (United States)

    Chen, Cheng-lung

    1985-01-01

    A viable rheological model should consist of both a time-independent part and a time-dependent part. A generalized viscoplastic fluid model that has both parts as well as two major rheological properties (i. e. , the normal stress effect and soil yield criteria) is shown to be sufficiently accurate, yet practical, for general use in debris flow modeling. Other rheological models, such as the Bingham plastic fluid model and the so-called Coulomb-viscous model, are compared in terms of the generalized viscoplastic fluid model.

  7. OpenDolphin: presentation models for compelling user interfaces

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    Shared applications run on the server. They still need a display, though, be it on the web or on the desktop. OpenDolphin introduces a shared presentation model to clearly differentiate between "what" to display and "how" to display. The "what" is managed on the server and is independent of the UI technology whereas the "how" can fully exploit the UI capabilities like the ubiquity of the web or the power of the desktop in terms of interactivity, animations, effects, 3D worlds, and local devices. If you run a server-centric architecture and still seek to provide the best possible user experience, then this talk is for you. About the speaker Dierk König (JavaOne Rock Star) works as a fellow for Canoo Engineering AG, Basel, Switzerland. He is a committer to many open-source projects including OpenDolphin, Groovy, Grails, GPars and GroovyFX. He is lead author of the "Groovy in Action" book, which is among ...

  8. Present status of the VMI and related models

    International Nuclear Information System (INIS)

    Scharff-Goldhaber, G.

    1980-05-01

    This article traces the evolution of the Variable Moment of Inertia model in its relation to the shell model, the Bohr-Mottelson model and the Interacting Boson Model. The discovery of a new type of spectrum, that of pseudomagic nuclei (isobars of doubly magic nuclei) is reported, and an explanation for their dynamics is suggested. The type of rotational motion underlying the ground state band of an e-e nucleus is shown to depend on whether the minimum number of valence nucleon pairs of one kind (neutrons or protons) is less than or equal to 2 or > 2. In the former case the alpha-dumbbell model holds; in the latter the two-fluid model

  9. Making sense to modelers: Presenting UML class model differences in prose

    DEFF Research Database (Denmark)

    Störrle, Harald

    2013-01-01

    Understanding the difference between two models, such as different versions of a design, can be difficult. It is a commonly held belief in the model differencing community that the best way of presenting a model difference is by using graph or tree-based visualizations. We disagree and present an...... by a controlled experiment that tests three alternatives to presenting model differences. Our findings support our claim that the approach presented here is superior to EMF Compare.......Understanding the difference between two models, such as different versions of a design, can be difficult. It is a commonly held belief in the model differencing community that the best way of presenting a model difference is by using graph or tree-based visualizations. We disagree and present...... an alternative approach where sets of low-level model differences are abstracted into high-level model differences that lend themselves to being presented textually. This format is informed by an explorative survey to elicit the change descriptions modelers use themselves. Our approach is validated...

  10. Western Wind and Solar Integration Study: Phase 2 (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Lew, D.; Brinkman, G.; Ibanez, E.; Lefton, S.; Kumar, N.; Venkataraman, S.; Jordan, G.

    2013-09-01

    This presentation summarizes the scope and results of the Western Wind and Solar Integration Study Phase 2, which examined operational impacts of high penetrations of variable renewable generation in the West.

  11. HYDROGEOLOGIC CASE STUDIE(PRESENTATION FOR MNA WORKSHOP)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  12. Presentation of Austrians recommended dispersion model for tunnel portals

    Energy Technology Data Exchange (ETDEWEB)

    Oettl, D.; Sturm, P.; Almbauer, R. [Inst. for Internal Combustion Engines and Thermodynamics, Graz Univ. of Technology (Austria)

    2004-07-01

    Street tunnels in cities are often suggested as solution to avoid daily congestions but also to prevent residential areas from high noise and air pollution emissions. In case of longitudinal ventilated tunnels high pollution levels may occur in the vicinity of the portals. The dispersion of pollutants from tunnel portals is considered to differ significantly from those of other sources, such as line or point sources. To the best of the authors knowledge, there exist currently two distinct dispersion models, which are especially designed to treat dispersion from tunnel portals. Okamoto et al proposed a diagnostic wind field model, where the dispersion is modelled using a Taylor-Galerkin-Forester filter method. Oettl et al. developed a Lagrangian-type model (GRAL TM 3.5=Graz Lagrangian model Tunnel Module version 3.5), which is briefly described in the next section. (orig.)

  13. On the complementary presentation of results of risk studies

    International Nuclear Information System (INIS)

    Ehrhardt, J.; Bayer, A.

    1983-01-01

    The presentation of the loss of years of life provides the opportunity to illustrate in complementary way the mortality risks evaluated as part of risk studies. As phase A of the DRS (German risk study nuclear power plants) bears upon the results of the American ''Reactor Safety Study'' (WASH 1400) it does not contain that factor of failure which has only been determined in subsequent studies. Phase B intends to present the results of risk assessments increasingly in form of abridged lifetime. (orig.) [de

  14. Spotlight on the presenter : a study into presentations of conference papers with PowerPoint

    NARCIS (Netherlands)

    Hertz, B.

    2015-01-01

    Abstract

    1. Introduction

    PowerPoint is the most widely used presentation software tool. As of 2012, PowerPoint had more than 200 million presenters worldwide. Presenters all over the world use the program. Some use it for university teaching, others

  15. Bonissone CIDU Presentation: Design of Local Fuzzy Models

    Data.gov (United States)

    National Aeronautics and Space Administration — After reviewing key background concepts in fuzzy systems and evolutionary computing, we will focus on the use of local fuzzy models, which are related to both kernel...

  16. Estimating net present value variability for deterministic models

    NARCIS (Netherlands)

    van Groenendaal, W.J.H.

    1995-01-01

    For decision makers the variability in the net present value (NPV) of an investment project is an indication of the project's risk. So-called risk analysis is one way to estimate this variability. However, risk analysis requires knowledge about the stochastic character of the inputs. For large,

  17. Dynamical reduction models: present status and future developments

    Energy Technology Data Exchange (ETDEWEB)

    Bassi, Angelo [Dipartimento di Fisica Teorica, Universita degli Studi di Trieste, Strada Costiera 11, 34014 Trieste (Italy); Mathematisches Institut der Ludwig-Maximilians Universitaet, Theresienstr. 39, 80333 Munich (Germany)

    2007-05-15

    We review the major achievements of the dynamical reduction program, showing why and how it provides a unified, consistent description of physical phenomena, from the microscopic quantum domain to the macroscopic classical one. We discuss the difficulties in generalizing the existing models in order to comprise also relativistic quantum field theories. We point out possible future lines of research, ranging from mathematical physics to phenomenology.

  18. Minimal Z' models: present bounds and early LHC reach

    International Nuclear Information System (INIS)

    Salvioni, Ennio; Zwirner, Fabio; Villadoro, Giovanni

    2009-01-01

    We consider 'minimal' Z' models, whose phenomenology is controlled by only three parameters beyond the Standard Model ones: the Z' mass and two effective coupling constants. They encompass many popular models motivated by grand unification, as well as many arising in other theoretical contexts. This parameterization takes also into account both mass and kinetic mixing effects, which we show to be sizable in some cases. After discussing the interplay between the bounds from electroweak precision tests and recent direct searches at the Tevatron, we extend our analysis to estimate the early LHC discovery potential. We consider a center-of-mass energy from 7 towards 10 TeV and an integrated luminosity from 50 to several hundred pb -1 , taking all existing bounds into account. We find that the LHC will start exploring virgin land in parameter space for M Z' around 700 GeV, with lower masses still excluded by the Tevatron and higher masses still excluded by electroweak precision tests. Increasing the energy up to 10 TeV, the LHC will start probing a wider range of Z' masses and couplings, although several hundred pb -1 will be needed to explore the regions of couplings favored by grand unification and to overcome the Tevatron bounds in the mass region around 250 GeV.

  19. The ELOCA fuel modelling code: past, present and future

    International Nuclear Information System (INIS)

    Williams, A.F.

    2005-01-01

    ELOCA is the Industry Standard Toolset (IST) computer code for modelling CANDU fuel under the transient coolant conditions typical of an accident scenario. Since its original inception in the early 1970's, the code has undergone continual development and improvement. The code now embodies much of the knowledge and experience of fuel behaviour gained by the Canadian nuclear industry over this period. ELOCA has proven to be a valuable tool for the safety analyst, and continues to be used extensively to support the licensing cases of CANDU reactors. This paper provides a brief and much simplified view of this development history, its current status, and plans for future development. (author)

  20. On the Present State of Information Society Studies.

    Science.gov (United States)

    Duff, Alistair S.

    2001-01-01

    Assesses the present condition of the emerging specialism of information society studies. Topics include the information economy; information technology; the information explosion; the Japanese version of information society; information society as social democracy; sociology and information science; scholarly journals; and the need for…

  1. Presentation of chronic daily headache : A clinical study

    NARCIS (Netherlands)

    Spierings, E L H; Schroevers, M.; Honkoop, P.C.; Sorbi, M.

    We studied the presentation of chronic daily headache in 258 patients from a private headache practice, 50 men and 208 women. Chronic daily headache was defined as headaches, occurring at least 5 days per week for at least 1 year. Seventy-seven percent of the patients experienced the onset of

  2. Western Wind and Solar Integration Study Phase 2 (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Lew, D.; Brinkman, G.; Ibanez, E.; Kumar, N.; Lefton, S.; Jordan, G.; Venkataraman, S.; King, J.

    2013-06-01

    This presentation accompanies Phase 2 of the Western Wind and Solar Integration Study, a follow-on to Phase 1, which examined the operational impacts of high penetrations of variable renewable generation on the electric power system in the West and was one of the largest variable generation studies to date. High penetrations of variable generation can induce cycling of fossil-fueled generators. Cycling leads to wear-and-tear costs and changes in emissions. Phase 2 calculated these costs and emissions, and simulated grid operations for a year to investigate the detailed impact of variable generation on the fossil-fueled fleet. The presentation highlights the scope of the study and results.

  3. Prospective study of emergency presentation of abdominal tuberculosis

    Directory of Open Access Journals (Sweden)

    Akhilesh R. Mishra

    2016-08-01

    Full Text Available Background: In developing countries like India, where poverty, malnutrition and overcrowding prevail, tuberculosis continues to be one of the important causes of morbidity, mortality and loss of working man hours. Abdominal tuberculosis (TB can affect the gastrointestinal tract, the peritoneum, lymph nodes of the small bowel mesentery or the solid viscera (e.g. liver, spleen, pancreas etc Patient of abdominal Koch’s can present as those with a chronic undulating course and those with an acute or subacute abdominal catastrophe. In emergency the patient may present with various presentations like stricture causing obstruction or with perforation and require a different management from those routine such cases Aim and Objective: To study the varied presentation of patients with Abdominal Tuberculosis as acute surgical abdomen presenting in emergency setting to those with a subacute course. To evaluate the line of management whether operative or conservative, the operative details, post operative course and the final outcome of the disease. To study the incidence of HIV positivity in patients with abdominal tuberculosis. Methods and material: The study was designed as a prospective observational study conducted during a study period between June 2006 and June 2008 in a tertiary care centre in Mumbai. All patients with a clinical suspicion of abdominal tuberculosis were included in the study with confirmation on histopathological examination. Patient’s written informed valid consent was taken after explaining the nature of study. Result and Conclusion: Age group commonly affected was between 21-30 years with male predominance. Amongst the various complications of abdominal tuberculosis intestinal obstruction was the most common mainly due to stricture and less commonly due to hyperplastic ileocaecal mass. Next common complication observed was free perforation of the intestine which occurs at a site proximal to a tight stricture. All patients were

  4. Spacelab experiment computer study. Volume 1: Executive summary (presentation)

    Science.gov (United States)

    Lewis, J. L.; Hodges, B. C.; Christy, J. O.

    1976-01-01

    A quantitative cost for various Spacelab flight hardware configurations is provided along with varied software development options. A cost analysis of Spacelab computer hardware and software is presented. The cost study is discussed based on utilization of a central experiment computer with optional auxillary equipment. Groundrules and assumptions used in deriving the costing methods for all options in the Spacelab experiment study are presented. The groundrules and assumptions, are analysed and the options along with their cost considerations, are discussed. It is concluded that Spacelab program cost for software development and maintenance is independent of experimental hardware and software options, that distributed standard computer concept simplifies software integration without a significant increase in cost, and that decisions on flight computer hardware configurations should not be made until payload selection for a given mission and a detailed analysis of the mission requirements are completed.

  5. Past, Present, and Future in the Scientific Study of Religion

    DEFF Research Database (Denmark)

    Mccorkle, William W.; Xygalatas, Dimitris

    2012-01-01

    The study of religion is by its nature and by its history multi-disciplinary, incorporating diverse research paradigms ranging from historiography to experimental approaches and from scientific positivism to postmodern reflection. At a conference on the Past, Present, and Future in the Scientific...... in the humani- ties. The Laboratory for the Experimental Research of Religion in Brno, who hosted this conference, is the product of these developments...

  6. DEVELOPING VISUAL PRESENTATION ATTITUDE RUBRIC: VALIDITY AND RELIABILITY STUDY

    OpenAIRE

    ATEŞ, Hatice KADIOĞLU; ADA, Sefer; BAYSAL, Z. Nurdan

    2015-01-01

    Abstract The aim of this study is to develop visual presentation attitude rubric which is valid and reliable for the 4th grade students. 218 students took part in this study from Engin Can Güre which located in Istanbul, Esenler. While preparing this assessment tool with 34 criterias , 6 university lecturers view have been taken who are experts in their field. The answer key sheet has 4 (likert )type options. The rubric has been first tested by Kaiser-Meyer Olkin and Bartletts tests an...

  7. Geothermal Exploration Case Studies on OpenEI (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Young, K.; Bennett, M.; Atkins, D.

    2014-03-01

    The U.S. Geological Survey (USGS) resource assessment (Williams et al., 2008) outlined a mean 30 GWe of undiscovered hydrothermal resource in the western United States. One goal of the U.S. Department of Energy's (DOE) Geothermal Technology Office (GTO) is to accelerate the development of this undiscovered resource. DOE has focused efforts on helping industry identify hidden geothermal resources to increase geothermal capacity in the near term. Increased exploration activity will produce more prospects, more discoveries, and more readily developable resources. Detailed exploration case studies akin to those found in oil and gas (e.g. Beaumont and Foster, 1990-1992) will give developers central location for information gives models for identifying new geothermal areas, and guide efficient exploration and development of these areas. To support this effort, the National Renewable Energy Laboratory (NREL) has been working with GTO to develop a template for geothermal case studies on the Geothermal Gateway on OpenEI. In 2012, the template was developed and tested with two case studies: Raft River Geothermal Area (http://en.openei.org/wiki/Raft_River_Geothermal_Area) and Coso Geothermal Area (http://en.openei.org/wiki/Coso_Geothermal_Area). In 2013, ten additional case studies were completed, and Semantic MediaWiki features were developed to allow for more data and the direct citations of these data. These case studies are now in the process of external peer review. In 2014, NREL is working with universities and industry partners to populate additional case studies on OpenEI. The goal is to provide a large enough data set to start conducting analyses of exploration programs to identify correlations between successful exploration plans for areas with similar geologic occurrence models.

  8. Study on Awakening Effect by Fragrance Presentation Against Drowsy Driving and Construction of Fragrance Presentation System

    Science.gov (United States)

    Kakamu, Yuki; Yoshikawa, Masahito; Shimizu, Takayuki; Yanagida, Yasuyuki; Nakano, Tomoaki; Yamamoto, Shin; Yamada, Muneo

    Traffic accidents caused by drowsy driving never disappear and easily result in fatal crash when heavy vehicle is involved. General methods to prevent drowsy driving are caution-advisory indicators and alarm sounds. However visual and auditory information are excessive enough to alert drivers. This study aims to focus on olfactory stimuli, which do not provoke interference with driving actions, and examine the effectiveness in combating drowsiness. Changing type of scent, we performed investigations on the effectiveness of each countermeasure to remain alert against drowsy driving.

  9. Adolescents' presentation of food in social media: An explorative study.

    Science.gov (United States)

    Holmberg, Christopher; E Chaplin, John; Hillman, Thomas; Berg, Christina

    2016-04-01

    The study aimed to explore how adolescents communicate food images in a widely used social media image-sharing application. We examined how and in what context food was presented and the type of food items that were frequently portrayed by following a youth related hashtag on Instagram. The hashtag #14år ("14 years") was used to find adolescent users on Instagram: these users public photo streams were then searched for food items they had shared with others. Food items were identified and categorized based on type of food and how the food items were presented. Most of the adolescent users (85%) shared images containing food items. A majority of the images (67.7%) depicted foods high in calories but low in nutrients. Almost half of these images were arranged as a still life with food brand names clearly exposed. Many of these images were influenced by major food marketing campaigns. Fruits and vegetables occurred in 21.8% of all images. This food group was frequently portrayed zoomed in with focus solely on the food, with a hashtag or caption expressing palatability. These images were often presented in the style of a cook book. Food was thus presented in varied ways. Adolescents themselves produced images copying food advertisements. This has clear health promotion implications since it becomes more challenging to monitor and tackle young people's exposure to marketing of unhealthy foods in these popular online networks because images are part of a lifestyle that the young people want to promote. Shared images contain personal recommendations, which mean that they may have a more powerful effect than commercial advertising. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Study of microorganisms present in deep geologic formations

    International Nuclear Information System (INIS)

    Camus, H.; Lion, R.; Bianchi, A.; Garcin, J.

    1987-01-01

    This work has been executed in the scope of the studies on high activity radioactive wastes storage in deep geological environments. The authors make reference to an as complete as possible literature on the existence of microorganisms in those environments or under similar conditions. Then they describe the equipment and methods they have implemented to perform their study of the populations present in three deep-reaching drill-holes in Auriat (France), Mol (Belgique) and Troon (Great Britain). The results of the study exhibit the presence of a certain biological activity, well adapted to that particular life environment. Strains appear to be very varied from the taxonomic point of view and seemingly show an important potential of mineral alteration when provided with an adequate source of energy. Complementary studies, using advanced techniques such as those employed during the work forming the basis of this paper, seem necessary for a more accurate evaluation of long-term risks of perturbation of a deep storage site [fr

  11. Present, past and future of the European rock fern Asplenium fontanum: combining distribution modelling and population genetics to study the effect of climate change on geographic range and genetic diversity.

    Science.gov (United States)

    Bystriakova, Nadia; Ansell, Stephen W; Russell, Stephen J; Grundmann, Michael; Vogel, Johannes C; Schneider, Harald

    2014-02-01

    Climate change is expected to alter the geographic range of many plant species dramatically. Predicting this response will be critical to managing the conservation of plant resources and the effects of invasive species. The aim of this study was to predict the response of temperate homosporous ferns to climate change. Genetic diversity and changes in distribution range were inferred for the diploid rock fern Asplenium fontanum along a South-North transect, extending from its putative last glacial maximum (LGM) refugia in southern France towards southern Germany and eastern-central France. This study reconciles observations from distribution models and phylogeographic analyses derived from plastid and nuclear diversity. Genetic diversity distribution and niche modelling propose that genetic diversity accumulates in the LGM climate refugium in southern France with the formation of a diversity gradient reflecting a slow, post-LGM range expansion towards the current distribution range. Evidence supports the fern's preference for outcrossing, contradicting the expectation that homosporous ferns would populate new sites by single-spore colonization. Prediction of climate and distribution range change suggests that a dramatic loss of range and genetic diversity in this fern is possible. The observed migration is best described by the phalanx expansion model. The results suggest that homosporous ferns reproducing preferentially by outcrossing accumulate genetic diversity primarily in LGM climate refugia and may be threatened if these areas disappear due to global climate change.

  12. [Face presentation: retrospective study of 32 cases at term].

    Science.gov (United States)

    Ducarme, G; Ceccaldi, P-F; Chesnoy, V; Robinet, G; Gabriel, R

    2006-05-01

    To determine the etiologic factors, circumstances of diagnosis, obstetrical management and complications of face presentation and to value the maternal and foetal prognosis of this presentation. Thirty-two cases of face presentation have been observed in the maternity wards of Reims and Troyes over the last 12 years. The incidence of face presentation was 0.7 per 1000 deliveries. Spontaneous vaginal delivery occurred with mento-anterior presentation 73% of the time and caesarean section was performed in 100% of mento-posterior presentation. There was no increasing rate of foetal or maternal mortality and morbidity with vaginal delivery. Face presentation is an unusual complication of pregnancy with obstetric factors that predispose the foetus to face presentation. The low foetal and maternal mortality and morbidity substantiate the effectiveness of conservative management in face presentation.

  13. Verification Techniques for Parameter Selection and Bayesian Model Calibration Presented for an HIV Model

    Science.gov (United States)

    Wentworth, Mami Tonoe

    Uncertainty quantification plays an important role when making predictive estimates of model responses. In this context, uncertainty quantification is defined as quantifying and reducing uncertainties, and the objective is to quantify uncertainties in parameter, model and measurements, and propagate the uncertainties through the model, so that one can make a predictive estimate with quantified uncertainties. Two of the aspects of uncertainty quantification that must be performed prior to propagating uncertainties are model calibration and parameter selection. There are several efficient techniques for these processes; however, the accuracy of these methods are often not verified. This is the motivation for our work, and in this dissertation, we present and illustrate verification frameworks for model calibration and parameter selection in the context of biological and physical models. First, HIV models, developed and improved by [2, 3, 8], describe the viral infection dynamics of an HIV disease. These are also used to make predictive estimates of viral loads and T-cell counts and to construct an optimal control for drug therapy. Estimating input parameters is an essential step prior to uncertainty quantification. However, not all the parameters are identifiable, implying that they cannot be uniquely determined by the observations. These unidentifiable parameters can be partially removed by performing parameter selection, a process in which parameters that have minimal impacts on the model response are determined. We provide verification techniques for Bayesian model calibration and parameter selection for an HIV model. As an example of a physical model, we employ a heat model with experimental measurements presented in [10]. A steady-state heat model represents a prototypical behavior for heat conduction and diffusion process involved in a thermal-hydraulic model, which is a part of nuclear reactor models. We employ this simple heat model to illustrate verification

  14. Present status of theories and data analyses of mathematical models for carcinogenesis

    International Nuclear Information System (INIS)

    Kai, Michiaki; Kawaguchi, Isao

    2007-01-01

    Reviewed are the basic mathematical models (hazard functions), present trend of the model studies and that for radiation carcinogenesis. Hazard functions of carcinogenesis are described for multi-stage model and 2-event model related with cell dynamics. At present, the age distribution of cancer mortality is analyzed, relationship between mutation and carcinogenesis is discussed, and models for colorectal carcinogenesis are presented. As for radiation carcinogenesis, models of Armitage-Doll and of generalized MVK (Moolgavkar, Venson, Knudson, 1971-1990) by 2-stage clonal expansion have been applied to analysis of carcinogenesis in A-bomb survivors, workers in uranium mine (Rn exposure) and smoking doctors in UK and other cases, of which characteristics are discussed. In analyses of A-bomb survivors, models above are applied to solid tumors and leukemia to see the effect, if any, of stage, age of exposure, time progression etc. In miners and smokers, stages of the initiation, promotion and progression in carcinogenesis are discussed on the analyses. Others contain the analyses of workers in Canadian atomic power plant, and of patients who underwent the radiation therapy. Model analysis can help to understand the carcinogenic process in a quantitative aspect rather than to describe the process. (R.T.)

  15. Present studies on the radio-sterilized drugs

    International Nuclear Information System (INIS)

    Marciniec, B.; Dettlaff, K.

    2007-01-01

    Lecture presents present status of radiosterilization of drugs and medical materials as compared to other sterilization methods. Literature review is shown on degradation of different kinds of drugs sterilized upon action of the sterilising doses of radiation

  16. Adaptive Anchoring Model: How Static and Dynamic Presentations of Time Series Influence Judgments and Predictions.

    Science.gov (United States)

    Kusev, Petko; van Schaik, Paul; Tsaneva-Atanasova, Krasimira; Juliusson, Asgeir; Chater, Nick

    2018-01-01

    When attempting to predict future events, people commonly rely on historical data. One psychological characteristic of judgmental forecasting of time series, established by research, is that when people make forecasts from series, they tend to underestimate future values for upward trends and overestimate them for downward ones, so-called trend-damping (modeled by anchoring on, and insufficient adjustment from, the average of recent time series values). Events in a time series can be experienced sequentially (dynamic mode), or they can also be retrospectively viewed simultaneously (static mode), not experienced individually in real time. In one experiment, we studied the influence of presentation mode (dynamic and static) on two sorts of judgment: (a) predictions of the next event (forecast) and (b) estimation of the average value of all the events in the presented series (average estimation). Participants' responses in dynamic mode were anchored on more recent events than in static mode for all types of judgment but with different consequences; hence, dynamic presentation improved prediction accuracy, but not estimation. These results are not anticipated by existing theoretical accounts; we develop and present an agent-based model-the adaptive anchoring model (ADAM)-to account for the difference between processing sequences of dynamically and statically presented stimuli (visually presented data). ADAM captures how variation in presentation mode produces variation in responses (and the accuracy of these responses) in both forecasting and judgment tasks. ADAM's model predictions for the forecasting and judgment tasks fit better with the response data than a linear-regression time series model. Moreover, ADAM outperformed autoregressive-integrated-moving-average (ARIMA) and exponential-smoothing models, while neither of these models accounts for people's responses on the average estimation task. Copyright © 2017 The Authors. Cognitive Science published by Wiley

  17. [DESCRIPTION AND PRESENTATION OF THE RESULTS OF ELECTROENCEPHALOGRAM PROCESSING USING AN INFORMATION MODEL].

    Science.gov (United States)

    Myznikov, I L; Nabokov, N L; Rogovanov, D Yu; Khankevich, Yu R

    2016-01-01

    The paper proposes to apply the informational modeling of correlation matrix developed by I.L. Myznikov in early 1990s in neurophysiological investigations, such as electroencephalogram recording and analysis, coherence description of signals from electrodes on the head surface. The authors demonstrate information models built using the data from studies of inert gas inhalation by healthy human subjects. In the opinion of the authors, information models provide an opportunity to describe physiological processes with a high level of generalization. The procedure of presenting the EEG results holds great promise for the broad application.

  18. Planetary X-ray studies: past, present and future

    Science.gov (United States)

    Branduardi-Raymont, Graziella

    2016-07-01

    Our solar system is a fascinating physics laboratory and X-ray observations are now firmly established as a powerful diagnostic tool of the multiple processes taking place in it. The science that X-rays reveal encompasses solar, space plasma and planetary physics, and the response of bodies in the solar system to the impact of the Sun's activity. This talk will review what we know from past observations and what we expect to learn in the short, medium and long term. Observations with Chandra and XMM-Newton have demonstrated that the origin of Jupiter's bright soft X-ray aurorae lies in the Charge eXchange (CX) process, likely to involve the interaction with atmospheric neutrals of local magnetospheric ions, as well as those carried in the solar wind. At higher energies electron bremsstrahlung is thought to be the X-ray emitting mechanism, while the whole planetary disk acts as a mirror for the solar X-ray flux via Thomson and fluorescent scattering. This 'X-ray mirror' phenomenon is all that is observed from Saturn's disk, which otherwise lacks X-ray auroral features. The Earth's X-ray aurora is bright and variable and mostly due to electron bremsstrahlung and line emission from atmospheric species. Un-magnetised planets, Venus and Mars, do not show X-ray aurorae but display the interesting combination of mirroring the solar X-ray flux and producing X-rays by Solar Wind Charge eXchange (SWCX) in their exospheres. These processes respond to different solar stimulation (photons and solar wind plasma respectively) hence their relative contributions are seen to vary according to the Sun's output. Present and future of planetary X-ray studies are very bright. We are preparing for the arrival of the Juno mission at Jupiter this summer and for coordinated observations with Chandra and XMM-Newton on the approach and later during Juno's orbital phase. These will allow direct correlation of the local plasma conditions with the X-ray emissions and the establishment of the

  19. Varied Presentation of Schwannoma – A Case Study

    Directory of Open Access Journals (Sweden)

    Ruquaya Mir

    2010-10-01

    Full Text Available Schwannomas can occur anywhere in the body with unusual presentation. They are difficult to diagnose preoperatively. Fine needle aspiration biopsy does not appear to provide an accurate preoperative diagnosis. Complete excision of the mass should be the goal of surgical excision.

  20. A retrospective study of fracture cases presented to university of ...

    African Journals Online (AJOL)

    In a nineteen years survey, 70 fracture cases were presented to the University of Maiduguri Veterinary Teaching Hospital (UMVTH). The percentage distribution of the fracture cases was determined according to species, etiology, affected bone, sex, age and type of fracture. The canine specie had the highest number of ...

  1. Violence and Alcohol: A Study of Injury Presentations to Emergency ...

    African Journals Online (AJOL)

    Demographic and injury circumstances data were collected on trauma patients consecutively presenting to hospitals. Alcohol consumption was assessed by either blood analysis or breath test, using a Lion Alcolmeter-SD2, in patients aged 16 years and above who arrived within an interval of 10 hours from the time of injury.

  2. Mean field theory of nuclei and shell model. Present status and future outlook

    International Nuclear Information System (INIS)

    Nakada, Hitoshi

    2003-01-01

    Many of the recent topics of the nuclear structure are concerned on the problems of unstable nuclei. It has been revealed experimentally that the nuclear halos and the neutron skins as well as the cluster structures or the molecule-like structures can be present in the unstable nuclei, and the magic numbers well established in the stable nuclei disappear occasionally while new ones appear. The shell model based on the mean field approximation has been successfully applied to stable nuclei to explain the nuclear structure as the finite many body system quantitatively and it is considered as the standard model at present. If the unstable nuclei will be understood on the same model basis or not is a matter related to fundamental principle of nuclear structure theories. In this lecture, the fundamental concept and the framework of the theory of nuclear structure based on the mean field theory and the shell model are presented to make clear the problems and to suggest directions for future researches. At first fundamental properties of nuclei are described under the subtitles: saturation and magic numbers, nuclear force and effective interactions, nuclear matter, and LS splitting. Then the mean field theory is presented under subtitles: the potential model, the mean field theory, Hartree-Fock approximation for nuclear matter, density dependent force, semiclassical mean field theory, mean field theory and symmetry, Skyrme interaction and density functional, density matrix expansion, finite range interactions, effective masses, and motion of center of mass. The subsequent section is devoted to the shell model with the subtitles: beyond the mean field approximation, core polarization, effective interaction of shell model, one-particle wave function, nuclear deformation and shell model, and shell model of cross shell. Finally structure of unstable nuclei is discussed with the subtitles: general remark on the study of unstable nuclear structure, asymptotic behavior of wave

  3. Modelling of present and future hydrology and solute transport at Forsmark. SR-Site Biosphere

    International Nuclear Information System (INIS)

    Bosson, Emma; Sassner, Mona; Sabel, Ulrika; Gustafsson, Lars-Goeran

    2010-10-01

    Radioactive waste from nuclear power plants in Sweden is managed by the Swedish Nuclear Fuel and Waste Management Co, SKB. SKB has performed site investigations at two different locations in Sweden, referred to as the Forsmark and Laxemar-Simpevarp areas, with the objective of siting a final repository for high-level radioactive waste. In 2009 a decision was made to focus on the Forsmark site. This decision was based on a large amount of empirical evidence suggesting Forsmark to be more suitable for a geological repository /SKB 2010b/. This report presents model results of numerical flow and transport modelling of surface water and near-surface groundwater at the Forsmark site for present and future conditions. Both temperate and periglacial climates have been simulated. Also different locations of the shoreline have been applied to the model, as well as different models of vegetation and Quaternary deposits. The modelling was performed using the modelling tool MIKE SHE and was based on the SDM-Site Forsmark MIKE SHE model (presented by Bosson et al. in SKB report R-08-09). The present work is a part of the biosphere modelling performed for the SR-Site safety assessment. The Forsmark area has a flat, small-scale topography. The study area is almost entirely below 20 m.a.s.l. (metres above sea level). There is a strong correlation between the topography of the ground surface and the ground water level in the Quaternary deposits (QD); thus, the surface water divides and the groundwater divides for the QD can be assumed to coincide. No major water courses flow through the catchment. Small brooks, which often dry out in the summer, connect the different sub-catchments with each other. The main lakes in the area, Lake Bolundsfjaerden, Lake Fiskarfjaerden, Lake Gaellsbotraesket and Lake Eckarfjaerden, all have sizes of less than one km2. The lakes are in general shallow. Approximately 70% of the catchment areas are covered by forest. Agricultural land is only present in

  4. Modelling of present and future hydrology and solute transport at Forsmark. SR-Site Biosphere

    Energy Technology Data Exchange (ETDEWEB)

    Bosson, Emma (Swedish Nuclear Fuel and Waste Management Co., Stocholm (Sweden)); Sassner, Mona; Sabel, Ulrika; Gustafsson, Lars-Goeran (DHI Sverige AB (Sweden))

    2010-10-15

    Radioactive waste from nuclear power plants in Sweden is managed by the Swedish Nuclear Fuel and Waste Management Co, SKB. SKB has performed site investigations at two different locations in Sweden, referred to as the Forsmark and Laxemar-Simpevarp areas, with the objective of siting a final repository for high-level radioactive waste. In 2009 a decision was made to focus on the Forsmark site. This decision was based on a large amount of empirical evidence suggesting Forsmark to be more suitable for a geological repository /SKB 2010b/. This report presents model results of numerical flow and transport modelling of surface water and near-surface groundwater at the Forsmark site for present and future conditions. Both temperate and periglacial climates have been simulated. Also different locations of the shoreline have been applied to the model, as well as different models of vegetation and Quaternary deposits. The modelling was performed using the modelling tool MIKE SHE and was based on the SDM-Site Forsmark MIKE SHE model (presented by Bosson et al. in SKB report R-08-09). The present work is a part of the biosphere modelling performed for the SR-Site safety assessment. The Forsmark area has a flat, small-scale topography. The study area is almost entirely below 20 m.a.s.l. (metres above sea level). There is a strong correlation between the topography of the ground surface and the ground water level in the Quaternary deposits (QD); thus, the surface water divides and the groundwater divides for the QD can be assumed to coincide. No major water courses flow through the catchment. Small brooks, which often dry out in the summer, connect the different sub-catchments with each other. The main lakes in the area, Lake Bolundsfjaerden, Lake Fiskarfjaerden, Lake Gaellsbotraesket and Lake Eckarfjaerden, all have sizes of less than one km2. The lakes are in general shallow. Approximately 70% of the catchment areas are covered by forest. Agricultural land is only present in

  5. Present status and problems of radionuclide studies in emergency cases

    International Nuclear Information System (INIS)

    Ogawa, Kiyoshi

    1983-01-01

    Scintigraphy is just right for diagnosing emergency cases due to its noninvasive and simple method, but emergency radionuclide studies have not become practical as a result of difficulty problems. Recently, nuclear medical devices have become easier to use in operations. It is become of this, that I have submitted this report regarding the problems of radionuclide studies in emergency cases. There were 101 cases (1.4 %) out of 7,310 cases for the year period Sept. 1981 - Aug. 1982. The studies consisted of 12 brain imaging cases, 9 plumonary imaging cases, 22 cardiac study cases (cardio-angiography cases 8, 99m-Tc-PYP myocardium imaging cases 12, 201-Tl myocardium imaging cases 2), 12 renal study cases, 11 G.I. blood loss cases, 35 peripheral angiography cases. In the near future, we will have to be ready to perform emergency radionuclide studies if the need arises. (author)

  6. Present status of radiochemical double β decay study (238U)

    International Nuclear Information System (INIS)

    Chevallier, A.; Chevallier, J.; Escoubes, B.; Schulz, N.; Sens, J.C.; Madic, C.; Maillard, C.

    1989-01-01

    The reasons for which the 238 U is a suitable candidate for the β β decay processes are explained. The strategy adopted for the radiochemical separation of the 234 U is given. A chemical system based on extraction chromatography is applied. The Pu IV breakthrough curves obtained at 40C during 238 Pu/ 238 U separation cycles are presented. A short description of the chromatographic facility is given. The solution adopted for the low background α spectrometer is explained

  7. Feminist Studies / Activities in Japan: present and future

    Directory of Open Access Journals (Sweden)

    Kazuko Takemura

    2010-01-01

    Full Text Available The essay provides an overview of feminist studies in Japan nowadays, exploring in particular how new perspectives on sexuality and postcolonial theory have been gradually incorporated into feminist studies since the 1990s. In relation to sexuality, approaches to gender-sexuality have been enriched by the incorporation of new theories from areas such as literary criticism, art or history, among others. This has allowed for new critical examinations of heterosexism and of questions about gender and sexuality, and has eventually derived in the institutionalization of feminist studies with a poststructuralist influence in the Japanese academia. The article also analyzes the incorporation of postcolonial studies into feminist studies, as well as the impact that the question of prostitution during the war has had on them.

  8. Rebuilding for Sustainability: Case Studies in the Making (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Billman, L.

    2013-06-01

    NREL has made significant contributions to communities suffering from natural disasters since 2007 in terms of technical assistance regarding energy efficiency and renewable energy options. NREL's work has covered all aspects of energy, including energy opportunities in community planning, policy design, new program design, and specific project design and implementation for energy related to electricity generation, building energy use, and transportation. This presentation highlights work done in New Orleans following Hurricane Katrina; Greensburg, Kansas, following a devastating tornado; and New York and New Jersey following Hurricane Sandy.

  9. The present and future on surface analysis for corrosion study

    International Nuclear Information System (INIS)

    Ohtsuka, Toshiaki

    2015-01-01

    Surface analysis for corrosion study was reviewed. For the study, the in-situ analysis was desired to describe the real feature. Light i.e., electromagnetic wave from gamma rays to infrared light has been used for the in-situ measurement of the corroded surface, although various ideas should be introduced for the study. For the application of the electromagnetic waves, a suitable window material and a suitable distance between the window and specimen surface depending on the properties of the wave must be selected. Electron spectroscopy including X-ray photoelectron spectroscopy (XPS) and Auger electron spectroscopy (AES) is not applicable for the in-situ study and, however, it is very available for the corrosion study from the following points; elemental analysis, state analysis of the element, and microscopic analysis. In future, the tip enhance Raman scattering (TERS) for which the scanning probe microscopy (SPM) is combined with the surface enhanced Raman scattering (SERS) may be useful for the in-situ corrosion study. (author)

  10. Acceptance of Addiction Prevention Exiting Methods and Presentation of Appropriate Model

    Directory of Open Access Journals (Sweden)

    Ali Asghar Savad-Kouhi

    2006-10-01

    Full Text Available Objective: The aim of this study is assessment of acceptance of addiction prevention existing methods and design and present of appropriate model. Materials & Methods: This research has done by survey and desariptive method by using questionnaire we assessed knowledge and belief of people about suggesting and existing methods of addiction prevention and their acceptence and finally design new and appropriate model of addiction prevention. For designing questionnaire, first exports and professors were openly interviewed and according their views final questionnaire was planned. We used questionnaire with 2 open ended and 61 close-ended tests for gathering data. The subjects of research were 2500 persons 13-35 years old that were selected by randomized sampling from 15 provinces. Results: The findings showed that according to people who were studied, they have positive beliefs about prevention methods and their effectiveness. According to findings a good model is inclusive model that able to do in four level: knowledge, change believe and attitude, control and change behavior. Conclusion: The people of study belive that acceptance of suggesting and existing methods of addiction prevention are effective direct and indirect to others, and appropriate model is inclusive model.

  11. Alligator Rivers Analogue project. Geochemical modelling of present-day groundwaters. Final Report - Volume 12

    Energy Technology Data Exchange (ETDEWEB)

    Sverjensky, D A [The John Hopkins Univ, Dept of Earth and Planetary Sciences, Baltimore (United States)

    1993-12-31

    The main purpose of this report is to summarize geochemical modeling studies of the present-day Koongarra groundwaters. Information on the present-day geochemistry and geochemical processes at Koongarra forms a basis for a present-day analogue for nuclear waste migration. The present-day analogue is built on studies of the mineralogy and petrology of the Koongarra deposit, and chemical analyses of present-day groundwaters from the deposit. The overall approach taken in the present study has been to carry out a series of aqueous speciation and state of saturation calculations, including chemical mass transfer calculations, to address the possible control over the chemistry of the present-day for the groundwaters at Koongarra. The most important implication of the present study for the migration of radionuclides is the strong role played by the water-rock interactions, both above and below the water table, influencing the overall chemical evolution of the groundwaters. Thus, the results show that the chemical evolution of waters is strongly controlled by the initial availability of CO{sub 2} and the mineral assemblage encountered, which together determine the major element evolution of the waters by controlling the pH. The relative rates of evolution of the pH and the oxidation state of the groundwaters are also critical to the mobility of uranium. The shallow Koongarra waters are sufficiently oxidising that they can dissolve and transport uranium even under acidic conditions. Under the more reducing condition of the deep groundwaters, is the pH level that permits uranium transport as carbonate complexes. However, if the oxidation state decreases to much lower levels, it would be expected that uranium become immobile. All the speciation and state of saturation calculations carried out in the present study are available from the author, on request 22 refs., 7 tabs., 18 figs.

  12. Alligator Rivers Analogue project. Geochemical modelling of present-day groundwaters. Final Report - Volume 12

    Energy Technology Data Exchange (ETDEWEB)

    Sverjensky, D. A. [The John Hopkins Univ, Dept of Earth and Planetary Sciences, Baltimore (United States)

    1992-12-31

    The main purpose of this report is to summarize geochemical modeling studies of the present-day Koongarra groundwaters. Information on the present-day geochemistry and geochemical processes at Koongarra forms a basis for a present-day analogue for nuclear waste migration. The present-day analogue is built on studies of the mineralogy and petrology of the Koongarra deposit, and chemical analyses of present-day groundwaters from the deposit. The overall approach taken in the present study has been to carry out a series of aqueous speciation and state of saturation calculations, including chemical mass transfer calculations, to address the possible control over the chemistry of the present-day for the groundwaters at Koongarra. The most important implication of the present study for the migration of radionuclides is the strong role played by the water-rock interactions, both above and below the water table, influencing the overall chemical evolution of the groundwaters. Thus, the results show that the chemical evolution of waters is strongly controlled by the initial availability of CO{sub 2} and the mineral assemblage encountered, which together determine the major element evolution of the waters by controlling the pH. The relative rates of evolution of the pH and the oxidation state of the groundwaters are also critical to the mobility of uranium. The shallow Koongarra waters are sufficiently oxidising that they can dissolve and transport uranium even under acidic conditions. Under the more reducing condition of the deep groundwaters, is the pH level that permits uranium transport as carbonate complexes. However, if the oxidation state decreases to much lower levels, it would be expected that uranium become immobile. All the speciation and state of saturation calculations carried out in the present study are available from the author, on request 22 refs., 7 tabs., 18 figs.

  13. Objectives and present status of the German risk evaluation study

    International Nuclear Information System (INIS)

    Birkhofer, A.; Koeberlein, K.; Heuser, F.W.

    1977-01-01

    For the German risk evaluation study, analogous to the Rasmussen report (WASH--1400), embarked upon in June 1976, the Kernkraftwerk Biblis B serves as the plant of reference. The first interim results are available for various sub-headings of the study. The main finding seems to be the decisive importance of the containment in limiting the accident consequences even in those cases where, on account of postulated failure of safety systems, the melt down of the reactor core is to be expected. (orig./HP) [de

  14. Fast reactor physics at CEA: present studies and future prospects

    International Nuclear Information System (INIS)

    Hammer, P.

    1980-09-01

    This paper aims at giving a general survey of the fast reactor core physics and shielding studies wich are in progress at CEA (1979-1983) in order to solve the neutronic problems related to: - core design optimization, - reactor operation and fuel management, - safety, for the development of fast commercial breeders in France after the SUPER-PHENIX 1 construction is achieved

  15. Nigeria Gas Utilization Study: Presentation of NGUS Findings

    International Nuclear Information System (INIS)

    2000-10-01

    The Nigeria gas utilization study is an assessment of the magnitude and distribution of Nigeria's discovered and undiscovered gas, an estimate of gas composition emphasizing ethane and liquids content. It also assesses, at a scoping level, the cost to develop, produce and deliver gas for domestic and export projects

  16. KioskAR: An Augmented Reality Game as a New Business Model to Present Artworks

    Directory of Open Access Journals (Sweden)

    Yoones A. Sekhavat

    2016-01-01

    Full Text Available This paper presents the architecture of KioskAR, which is a pervasive game implemented using augmented reality (AR. This game introduces a new business model that makes it possible for players to present their artworks in virtual kiosks using augmented reality, while they are having fun playing the game. In addition to competition between the players in the game, this game requires social interaction between players to earn more points. A user study is conducted to evaluate the sense of presence and the usability of the application. The results of experiments show that KioskAR can achieve a high level of usability as well as sense of presence.

  17. Are sawfishes still present in Mozambique? A baseline ecological study

    Directory of Open Access Journals (Sweden)

    Ruth H. Leeney

    2017-02-01

    Full Text Available Sawfishes (Pristidae were formerly abundant in the western Indian Ocean, but current data on sawfish presence and distribution are lacking for most of the region. This paper summarises historical records of sawfishes in Mozambican waters and presents the findings of the first assessment of the presence and status of sawfishes in Mozambique. A countrywide baseline assessment was undertaken between May and July 2014, using interviews with artisanal, semi-industrial and industrial fishers, fish traders and fisheries monitoring staff as the primary source of information on sawfish distribution, recent catches, socio-economic value and cultural importance. Additional interviews were conducted via email or telephone with individuals running sport fishing operations or who otherwise had considerable experience interacting with the fishing sectors or the marine environment in Mozambique. Where encountered, sawfish rostra were photographed and a series of measurements and associated data were collected. In total, 200 questionnaire surveys and seven interviews with recreational fishing and dive operators were conducted, and 19 rostra were documented from museum archives and private collections, belonging to two sawfish species, the Largetooth Sawfish (Pristis pristis and Green Sawfish (P. zijsron. The most recent captures of sawfishes were reported to have occurred in 2014. Two key sites were identified where both recent encounters were reported and numerous Largetooth Sawfish rostra were documented. Gill nets were the fishing gear most commonly attributed to sawfish catches. Sawfishes did not hold any cultural importance in Mozambique, but they have at least some socio-economic importance to artisanal fishers, primarily through the sale of their fins. The meat did not appear to be held in high regard and was usually consumed locally. Sampling and further research is now required to confirm the presence of sawfishes and to assess the primary threats to

  18. Are sawfishes still present in Mozambique? A baseline ecological study.

    Science.gov (United States)

    Leeney, Ruth H

    2017-01-01

    Sawfishes (Pristidae) were formerly abundant in the western Indian Ocean, but current data on sawfish presence and distribution are lacking for most of the region. This paper summarises historical records of sawfishes in Mozambican waters and presents the findings of the first assessment of the presence and status of sawfishes in Mozambique. A countrywide baseline assessment was undertaken between May and July 2014, using interviews with artisanal, semi-industrial and industrial fishers, fish traders and fisheries monitoring staff as the primary source of information on sawfish distribution, recent catches, socio-economic value and cultural importance. Additional interviews were conducted via email or telephone with individuals running sport fishing operations or who otherwise had considerable experience interacting with the fishing sectors or the marine environment in Mozambique. Where encountered, sawfish rostra were photographed and a series of measurements and associated data were collected. In total, 200 questionnaire surveys and seven interviews with recreational fishing and dive operators were conducted, and 19 rostra were documented from museum archives and private collections, belonging to two sawfish species, the Largetooth Sawfish ( Pristis pristis) and Green Sawfish ( P. zijsron) . The most recent captures of sawfishes were reported to have occurred in 2014. Two key sites were identified where both recent encounters were reported and numerous Largetooth Sawfish rostra were documented. Gill nets were the fishing gear most commonly attributed to sawfish catches. Sawfishes did not hold any cultural importance in Mozambique, but they have at least some socio-economic importance to artisanal fishers, primarily through the sale of their fins. The meat did not appear to be held in high regard and was usually consumed locally. Sampling and further research is now required to confirm the presence of sawfishes and to assess the primary threats to sawfishes in

  19. Study on tooth development, past, present, and future.

    Science.gov (United States)

    Jung, Han-Sung; Hitoshi, Yamamoto; Kim, Hee-Jin

    2003-04-01

    For decades, the understanding of craniofacial development has been a central issue in odontology and developmental biology. As a consequence, a significant number of deformities are being studied for their variety of genotype and phenotype. Although there is little doubt about the essential roles of homeobox genes, transcription factors, and growth factors, we now know at least the fundamental strategy of craniofacial biology. The tooth as an organ performs a whole range of functions, each of which is truly indispensable for the maintenance of life. The possession of teeth is, therefore, obviously coupled with the complication of the natural structure of an individual organism. In the following, we shall focus on a brief history of tooth studies and some suggestions for obtaining a full understanding of teeth in the future. Copyright 2003 Wiley-Liss, Inc.

  20. Evolutionary Studies in Business: A Presentation of a New Journal

    OpenAIRE

    Fernández Pérez, Paloma; Valls Pasola, Jaume

    2016-01-01

    The Journal of Evolutionary Studies in Business is a new open access journal led by an international interdisciplinary team of scholars located in eight institutions from three continents who wants to attract contributions that help shed light on the new questions, challenges, methodologies and realities, faced by businesses in an evolutionary perspective. The journal calls particularly for review essays that deal with new research topics about business, and provide useful overviews of...

  1. Detailed study of transmutation scenarios involving present day reactor technologies

    International Nuclear Information System (INIS)

    2003-01-01

    This document makes a detailed technical evaluation of three families of separation-transmutation scenarios for the management of radioactive wastes. These scenarios are based on 2 parks of reactors which recycle plutonium and minor actinides in an homogeneous way. A first scenario considers the multi-recycling of Pu and Np and the mono-recycling of Am and Cm using both PWRs and FBRs. A second scenario is based on PWRs only, while a third one considers FBRs only. The mixed PWR+FBR scenario requires innovative options and gathers more technical difficulties due to the americium and curium management in a minimum flux of materials. A particular attention has been given to the different steps of the fuel cycle (fuels and targets fabrication, burnup, spent fuel processing, targets management). The feasibility of scenarios of homogeneous actinides recycling in PWRs-only and in FBRs-only has been evaluated according to the results of the first scenario: fluxes of materials, spent fuel reprocessing by advanced separation, impact of the presence of actinides on PWRs and FBRs operation. The efficiency of the different scenarios on the abatement of wastes radio-toxicity is presented in conclusion. (J.S.)

  2. Present status of nuclear power safety studies in JAERI

    International Nuclear Information System (INIS)

    1989-01-01

    Japan Atomic Energy Research Institute carries out the safety research required for ensuring safety accompanying the development and utilization of atomic energy, dividing the roles with industrial circules, universities and other public research institutes. First, it carries out the research based on the yearly program of safety research, in which the subjects of safety research that the state should execute are decided. Next, it carries out a series of the safety verification test on atomic energy facilities entrusted by the state using the special account for power source development promotion countermeasures. Besides, it carries out the safety research on the specific subjects entrusted by outside organizations. The object and range of atomic energy safety at present are roughly divided into four fields, that is, nuclear power stations, nuclear fuel facilities, waste treatment and disposal, and environmental radioactivity. In order to advance the research effectively, in addition to the generalization department and the execution department, various committees are organized. In 1988, about 260 persons engaged in these four research fields, and the budget for fiscal year 1988 was about 17.4 billion yen. (K.I.)

  3. Toroidal Continuously Variable Transmission Systems: Terminology and Present Studies

    Directory of Open Access Journals (Sweden)

    Ahmet YILDIZ

    2014-04-01

    Full Text Available The use of continuously variable transmission systems in many different areas such as aerospace, robotics, machinery and automotive industries as an alternative to conventional speed changers with constant ratio becomes widely.Especially in the automotive industry, these systems have been used increasingly, since they enable that internal combustion engines in vehicles run at optimal speeds, and consequently provide considerable fuel savings and therefore lower emission values and also they provide powerful acceleration and quiet working. CVT systems have several constructive variants such as belted, chained, balled, toroidal etc. In this paper, toroidal CVT systems based on elastohydrodynamic principles are concerned with, and fundamental works of last two decades in this field are reviewed. However, the relevant terminology and dynamics along with the control of these systems are briefly treated for better understanding of the literature mentioned. Attention is drawn to the lack of some significant issues in present research works, and potential future works are pointed out. This paper, to the authors’ knowledge, will be the first review on toroidal CVT systems in Turkish literature

  4. Present status of radiochemical double beta decay study (238U)

    International Nuclear Information System (INIS)

    Madic, C.; Maillard, C.; Chevallier, A.; Chevallier, J.; Escoubes, B.; Schulz, N.; Sens, J.C.

    1989-01-01

    A sensitive experiment has been designed that will be able to measure an assumed half-life of 1.9x10 22 yr. This double beta corresponds to the activity of 27000 238 Pu nuclei formed during a year, in a 200 m deep mine, from 300 kg of 238 U, giving 210 alpha decays per year. Plutonium 238 et 239 will be determined by alpha spectroscopy after extraction chromatography. Experimental studies were undertaken to select the best conditions for running the extraction chromatography cycles

  5. Evolutionary Studies in Business: A Presentation of a New Journal

    Directory of Open Access Journals (Sweden)

    Paloma Fernández Pérez

    2016-01-01

    Full Text Available The Journal of Evolutionary Studies in Business is a new open access journal led by an international interdisciplinary team of scholars located in eight institutions from three continents who wants to attract contributions that help shed light on the new questions, challenges, methodologies and realities, faced by businesses in an evolutionary perspective. The journal calls particularly for review essays that deal with new research topics about business, and provide useful overviews of the key ideas, scholars, and debates about important research topics concerning business and its environment. The strategic areas of interest for submissions from authors are: Management Challenges, Entrepreneurship, Science and Business, Creative Industries, International Business, Business History, and Latin American Businesses. JESB will also publish articles about relevant online resources that contain information of interest to academic scholars and business practitioners.

  6. Present Status of Historical Seismicity Studies in Colombia and Venezuela

    Science.gov (United States)

    Sarabia, A.; Cifuentes, H.; Altez Ortega, R.; Palme, C.; Dimate, C.

    2013-05-01

    After the publication of the SISRA (CERESIS-1985) regional project, a unified catalog of seismic parameters and intensities for South America, researchers in historical seismicity have continued advancing on different scales in the area of this study of seismic hazard. The most important initiatives carried out in this area in Colombia and Venezuela can be grouped as follows: a) Reviews of destructive earthquakes in national and international historic archives, principally by Altez and FUNVISIS in Venezuela and Espinosa, Salcedo, and Sarabia et al in Colombia, leading to the preparation of seismologic catalogues, scientific and dissemination articles, reports, books, among others. b) Organization and systematization of historic information to develop public domain data bases and information, specifically the Historic Seismologic Teleinformation System in Venezuela, carried out between 2004 and 2008 under the coordination of Christl Palme and accessible on-line: http://sismicidad.ciens.ula.ve. As well, the "Historia Sísmica de Colombia 1550-1830" (Seismic History in Colombia 1550-1830) data base, in CD-ROM, by Espinosa Baquero (2003) and the historic seismicity information system of Colombia (Servicio Geológico Colombiano-Universidad Nacional de Colombia), published on the internet in 2012: http://agata.ingeominas.gov.co:9090/SismicidadHistorica/. c) Macroseismic studies for the development of intensity attenuation equations and the quantification and revaluation of basic historic earthquake parameters using isoseismal maps (Rengifo et al., Palme et al., Salcedo et al., among others) and procedures such as Boxer and Bakun & Wentworth (Palme et al., Dimaté, among others), which have produced significant changes in the parameters of some of the large earthquakes. d) Symposiums of researchers to promote interest and development in the discipline, including Jornadas Venezolanas de Sismología Histórica (Venezuelan Congress of Historical Seismology), held

  7. PIXE in cultural heritage studies: present role and new challenges

    International Nuclear Information System (INIS)

    Calligaro, T.; Dran, J.-C.

    2013-01-01

    Full text: The non-destructive study of artistic and archaeological objects relies on the use of a large panel of modern analytical tools. Among them, PIXE plays a prominent role due to its almost unique combination of excellent analytical features in terms of sensitivity and accuracy combined with a non-destructive and even non-invasive character. the latter advantage stems from extensive instrumental progress - like the external beam - carried out since the advent of PIXE in the 1970s to account for the precious and unique nature of artworks and archaeological artifacts that preclude any sampling or damage. the situation has however evolved in the recent years as several competing techniques providing non-destructively the chemical composition have arisen, which more or less shake the privileged status of PIXE. On one hand, analytical techniques implemented with tabletop or movable XRF instruments have been massively developed, which allow in situ analysis and represent a progress in terms of artworks safety and flexibility of analysis. On the other hand, access to synchrotron radiation facilities is becoming easier and therefore the use of the powerful X-ray absorption techniques (XANES, EXAFS), that add chemical environment information to the elemental analysis, is progressively gaining popularity. Considering these trends, it seems important to reassess the place of PIXE in the field of art and archaeology and to underline its specific assets. the aim of this article is to pinpoint the situation where PIXE is the best analytical tool with regard to the specificity of art and archaeological items and to stress the new challenges it will have to face. Case studies carried out with the AGLAE facility of the C2RMF will illustrate the situations where PIXE exhibits specific advantages: Light element measurement. The high ionization cross section of light elements by charged particles favors the accurate measurement of sodium, magnesium, aluminum and silicon, whose

  8. PIXE in cultural heritage studies: present role and new challenges

    Energy Technology Data Exchange (ETDEWEB)

    Calligaro, T.; Dran, J.-C. [Centre de Recherche et de Restauration des Musées de France, Palais du Louvre, Paris (France)

    2013-07-01

    Full text: The non-destructive study of artistic and archaeological objects relies on the use of a large panel of modern analytical tools. Among them, PIXE plays a prominent role due to its almost unique combination of excellent analytical features in terms of sensitivity and accuracy combined with a non-destructive and even non-invasive character. the latter advantage stems from extensive instrumental progress - like the external beam - carried out since the advent of PIXE in the 1970s to account for the precious and unique nature of artworks and archaeological artifacts that preclude any sampling or damage. the situation has however evolved in the recent years as several competing techniques providing non-destructively the chemical composition have arisen, which more or less shake the privileged status of PIXE. On one hand, analytical techniques implemented with tabletop or movable XRF instruments have been massively developed, which allow in situ analysis and represent a progress in terms of artworks safety and flexibility of analysis. On the other hand, access to synchrotron radiation facilities is becoming easier and therefore the use of the powerful X-ray absorption techniques (XANES, EXAFS), that add chemical environment information to the elemental analysis, is progressively gaining popularity. Considering these trends, it seems important to reassess the place of PIXE in the field of art and archaeology and to underline its specific assets. the aim of this article is to pinpoint the situation where PIXE is the best analytical tool with regard to the specificity of art and archaeological items and to stress the new challenges it will have to face. Case studies carried out with the AGLAE facility of the C2RMF will illustrate the situations where PIXE exhibits specific advantages: Light element measurement. The high ionization cross section of light elements by charged particles favors the accurate measurement of sodium, magnesium, aluminum and silicon, whose

  9. Modeling and cellular studies

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    Testing the applicability of mathematical models with carefully designed experiments is a powerful tool in the investigations of the effects of ionizing radiation on cells. The modeling and cellular studies complement each other, for modeling provides guidance for designing critical experiments which must provide definitive results, while the experiments themselves provide new input to the model. Based on previous experimental results the model for the accumulation of damage in Chlamydomonas reinhardi has been extended to include various multiple two-event combinations. Split dose survival experiments have shown that models tested to date predict most but not all the observed behavior. Stationary-phase mammalian cells, required for tests of other aspects of the model, have been shown to be at different points in the cell cycle depending on how they were forced to stop proliferating. These cultures also demonstrate different capacities for repair of sublethal radiation damage

  10. Pancreatic ductal adenocarcinoma presenting with acute and chronic pancreatitis as initial presentation: is prognosis better? A comparison study..

    Science.gov (United States)

    Thorat, Ashok; Huang, Wen-Hsuan; Yeh, Ta-Sen; Jan, Yi-Yan; Hwang, Tsann-Long

    2014-10-01

    Pancreatic ductal adenocarcinoma (PDAC) may present with acute and /or chronic pancreatitis due to pancreatic ductal obstruction causing diagnostic dilemma. The aim of this retrospective study was to investigate the outcome and prognosis of the patients of PDAC presenting with pancreatitis. From 1991 to 2009, 298 patients with PDAC that underwent surgical treatment were retrospectively studied and divided in two groups depending upon initial symptomatic presentation. Group A (n=254) comprised patients without pancreatitis while group B (n=44) patients presented with acute and/or chronic pancreatitis initially. All the patients in studied cohort were surgically treated. Mean age of group A was 63.1 years & for group B it was 62.9 years. Location of tumor was in head of the pancreas in 66.14% of group A patients (n=168) and 61.36% of group B patients (n=27). Although statistically insignificant, the patients in group B had overall better 5-year survival than the patients in group A (20% vs 15.9%). This retrospective study highlights the overall better survival of PDAC patients presenting with acute and/or chronic pancreatitis than those without as contrary to previous reports which stated the poor prognosis of PDAC patients if associated with underlying pancreatitis.

  11. A review of the evidence linking adult attachment theory and chronic pain: presenting a conceptual model.

    Science.gov (United States)

    Meredith, Pamela; Ownsworth, Tamara; Strong, Jenny

    2008-03-01

    It is now well established that pain is a multidimensional phenomenon, affected by a gamut of psychosocial and biological variables. According to diathesis-stress models of chronic pain, some individuals are more vulnerable to developing disability following acute pain because they possess particular psychosocial vulnerabilities which interact with physical pathology to impact negatively upon outcome. Attachment theory, a theory of social and personality development, has been proposed as a comprehensive developmental model of pain, implicating individual adult attachment pattern in the ontogenesis and maintenance of chronic pain. The present paper reviews and critically appraises studies which link adult attachment theory with chronic pain. Together, these papers offer support for the role of insecure attachment as a diathesis (or vulnerability) for problematic adjustment to pain. The Attachment-Diathesis Model of Chronic Pain developed from this body of literature, combines adult attachment theory with the diathesis-stress approach to chronic pain. The evidence presented in this review, and the associated model, advances our understanding of the developmental origins of chronic pain conditions, with potential application in guiding early pain intervention and prevention efforts, as well as tailoring interventions to suit specific patient needs.

  12. Present status on atomic and molecular data relevant to fusion plasma diagnostics and modeling

    International Nuclear Information System (INIS)

    Tawara, H.

    1997-01-01

    This issue is the collection of the paper presented status on atomic and molecular data relevant to fusion plasma diagnostics and modeling. The 10 of the presented papers are indexed individually. (J.P.N.)

  13. Modeling nonstationary extreme wave heights in present and future climates of Greek Seas

    Directory of Open Access Journals (Sweden)

    Panagiota Galiatsatou

    2016-01-01

    Full Text Available In this study the generalized extreme value (GEV distribution function was used to assess nonstationarity in annual maximum wave heights for selected locations in the Greek Seas, both in the present and future climates. The available significant wave height data were divided into groups corresponding to the present period (1951–2000, a first future period (2001–2050, and a second future period (2051–2100. For each time period, the parameters of the GEV distribution were specified as functions of time-varying covariates and estimated using the conditional density network (CDN. For each location and selected time period, a total number of 29 linear and nonlinear models were fitted to the wave data, for a given combination of covariates. The covariates used in the GEV-CDN models consisted of wind fields resulting from the Regional Climate Model version 3 (RegCM3 developed by the International Center for Theoretical Physics (ICTP with a spatial resolution of 10 km × 10 km, after being processed using principal component analysis (PCA. The results obtained from the best fitted models in the present and future periods for each location were compared, revealing different patterns of relationships between wind components and extreme wave height quantiles in different parts of the Greek Seas and different periods. The analysis demonstrates an increase of extreme wave heights in the first future period as compared with the present period, causing a significant threat to Greek coastal areas in the North Aegean Sea and the Ionian Sea.

  14. 3D instantaneous dynamics modeling of present-day Aegean subduction

    Science.gov (United States)

    Glerum, Anne; Spakman, Wim; van Hinsbergen, Douwe; Pranger, Casper

    2017-04-01

    To study the sensitivity of surface observables to subduction and mantle flow, i.e. the coupling of crustal tectonics and the underlying mantle dynamics, we have developed 3D numerical models of the instantaneous crust-mantle dynamics of the eastern Mediterranean. These models comprise both a realistic crust-lithosphere system and the underlying mantle. The focus for this presentation lies on the regional crustal flow response to the present-day Aegean subduction system. Our curved model domain measures 40°x40°x2900km with the Aegean subduction system taken as the geographic center. Model set-ups are based on geological and geophysical data of the eastern Mediterranean. We first create a 3D synthetic geometry of the crust-lithosphere system in a stand-alone program, including the present-day configuration of the plates in the region and crust and lithosphere thickness variations abstracted from Moho and LAB maps (Faccenna et al., 2014, Carafa et al., 2015). In addition we construct the geometry of the Aegean slab from a seismic tomography model (UU-P07; Amaru, 2007) and earthquake hypocenters (NCEDC, 2014). Geometries are then imported into the finite element code ASPECT (Kronbichler et al., 2012) using specially designed plugins. The mantle initial temperature conditions can include deviations from an adiabatic profile obtained from conversion of the UU-P07 seismic velocity anomalies to temperature anomalies using a depth-dependent scaling (Karato, 2008). We model compressible mantle flow for which material properties are obtained from thermodynamics P-T lookup-tables (Perple_X, Connolly, 2009) in combination with nonlinear viscoplastic rheology laws. Sublithospheric flow through the lateral model boundaries is left free via open boundary conditions (Chertova et al., 2012), while plate motion is prescribed at the model sides in terms of relative as well as absolute plate motion velocities (e.g. Doubrovine et al., 2012). So far, we used a free-slip surface, but

  15. Presenting the students’ academic achievement causal model based on goal orientation

    Directory of Open Access Journals (Sweden)

    EBRAHIM NASIRI

    2017-10-01

    Full Text Available Introduction: Several factors play a role in academic achievement, individual’s excellence and capability to do actions and tasks that the learner is in charge of in learning areas. The main goal of this study was to present academic achievement causal model based on the dimensions of goal orientation and learning approaches among the students of Medical Science and Dentistry courses in Guilan University of Medical Sciences in 2013. Methods: This study is based on a cross-sectional model. The participants included 175 first and second year students of the Medical and Dentistry schools in Guilan University of Medical Sciences selected by random cluster sampling [121 persons (69% Medical Basic Science students and 54 (30.9% Dentistry students]. The measurement tool included the Goal Orientation Scale of Bouffard and Study Process Questionnaire of Biggs and the students’ Grade Point Average. The study data were analyzed using Pearson correlation coefficient and structural equations modeling. SPSS 14 and Amos were used to analyze the data. Results: The results indicated a significant relationship between goal orientation and learning strategies (P<0.05. In addition, the results revealed that a significant relationship exists between learning strategies [Deep Learning (r=0.37, P<0.05, Surface Learning (r=-0.21, P<0.05], and academic achievement. The suggested model of research is fitted to the data of the research. Conclusion: Results showed that the students’ academic achievement model fits with experimental data, so it can be used in learning principles which lead to students’ achievement in learning.

  16. Presenting a conceptual model of data collection to manage the groundwater quality

    Directory of Open Access Journals (Sweden)

    Nourbakhsh Zahra

    2017-12-01

    Full Text Available A conceptual model was proposed in the present study, which highlighted important independent and dependent variables in order to managing the groundwater quality. Furthermore, the methods of selection of variable and collection of related data were explained. The study was carried out in the Tajan Plain, north of Iran; 50 drinking wells were considered as sampling points. In this model the Analytical Hierarchy Process (AHP was proposed to select the indicator water quality parameters. According to expert opinions and characteristics of the study area ten factors were chosen as variables influencing the quality of groundwater (land use types, lithology units, geology units, distance of wells to the outlet, distance to the residential areas, direction toward the residential areas, depth of the groundwater table, the type of aquifer, transmissivity and population. Geographic Information System (AecGIS 9.3 was used to manage the spatial-based variables and the data of non-spatial-based variables were obtained from relevant references. A database, which contains all collected data related to groundwater quality management in the studied area, was created as the output of the model. The output of this conceptual model can be used as an input for quantitative and mathematical models. Results show that 6 parameters (sulphate, iron, nitrate, electrical conductivity, calcium, and total dissolved solids (TDS were the best indicators for groundwater quality analysis in the area. More than 50% of the wells were drilled in the depth of groundwater table about 5 meters, in this low depth pollutants can load into the wells and also 78% of the wells are located within 5 km from the urban area; it can be concluded from this result that the intensive urban activities could affect groundwater quality.

  17. A binomial random sum of present value models in investment analysis

    OpenAIRE

    Βουδούρη, Αγγελική; Ντζιαχρήστος, Ευάγγελος

    1997-01-01

    Stochastic present value models have been widely adopted in financial theory and practice and play a very important role in capital budgeting and profit planning. The purpose of this paper is to introduce a binomial random sum of stochastic present value models and offer an application in investment analysis.

  18. Robust Synchronization Models for Presentation System Using SMIL-Driven Approach

    Science.gov (United States)

    Asnawi, Rustam; Ahmad, Wan Fatimah Wan; Rambli, Dayang Rohaya Awang

    2013-01-01

    Current common Presentation System (PS) models are slide based oriented and lack synchronization analysis either with temporal or spatial constraints. Such models, in fact, tend to lead to synchronization problems, particularly on parallel synchronization with spatial constraints between multimedia element presentations. However, parallel…

  19. Imaging and modeling of collagen architecture in living tissue with polarized light transfer (Conference Presentation)

    Science.gov (United States)

    Ramella-Roman, Jessica C.; Stoff, Susan; Chue-Sang, Joseph; Bai, Yuqiang

    2016-03-01

    The extra-cellular space in connective tissue of animals and humans alike is comprised in large part of collagen. Monitoring of collagen arrangement and cross-linking has been utilized to diagnose a variety of medical conditions and guide surgical intervention. For example, collagen monitoring is useful in the assessment and treatment of cervical cancer, skin cancer, myocardial infarction, and non-arteritic anterior ischemic optic neuropathy. We have developed a suite of tools and models based on polarized light transfer for the assessment of collagen presence, cross-linking, and orientation in living tissue. Here we will present some example of such approach applied to the human cervix. We will illustrate a novel Mueller Matrix (MM) imaging system for the study of cervical tissue; furthermore we will show how our model of polarized light transfer through cervical tissue compares to the experimental findings. Finally we will show validation of the methodology through histological results and Second Harmonic imaging microscopy.

  20. ICRF edge modeling studies

    Energy Technology Data Exchange (ETDEWEB)

    Lehrman, I.S. (Grumman Corp. Research Center, Princeton, NJ (USA)); Colestock, P.L. (Princeton Univ., NJ (USA). Plasma Physics Lab.)

    1990-04-01

    Theoretical models have been developed, and are currently being refined, to explain the edge plasma-antenna interaction that occurs during ICRF heating. The periodic structure of a Faraday shielded antenna is found to result in strong ponderomotive force in the vicinity of the antenna. A fluid model, which incorporates the ponderomotive force, shows an increase in transport to the Faraday shield. A kinetic model shows that the strong antenna near fields act to increase the energy of deuterons which strike the shield, thereby increasing the sputtering of shield material. Estimates of edge impurity harmonic heating show no significant heating for either in or out-of-phase antenna operation. Additionally, a particle model for electrons near the shield shows that heating results from the parallel electric field associated with the fast wave. A quasilinear model for edge electron heating is presented and compared to the particle calculations. The models' predictions are shown to be consistent with measurements of enhanced transport. (orig.).

  1. Past, Present, and Future Anthropogenic Emissions over Asia: a Regional Air Quality Modeling Perspective

    Science.gov (United States)

    Woo, Jung-Hun; Jung, Bujeon; Choi, Ki-Chul; Seo, Ji-Hyun; Kim, Tae Hyung; Park, Rokjin J.; Youn, Daeok; Jeong, Jaein; Moon, Byung-Kwon; Yeh, Sang-Wook

    2010-05-01

    Climate change will also affect future regional air quality which has potential human health, ecosystem, and economic implications. To analyze the impacts of climate change on Asian air quality, the NIER (National Institute of Environmental Research, Korea) integrated modeling framework was developed based on global-to-regional climate and atmospheric chemistry models. In this study, we developed emission inventories for the modeling framework for 1980~2100 with an emphasis on Asia emissions. Two emission processing systems which have functions of emission projection, spatial/temporal allocation, and chemical speciation have been also developed in support of atmospheric chemistry models including GEOS-Chem and Models-3/CMAQ. Asia-based emission estimates, projection factors, temporal allocation parameters were combined to improve regional modeling capability of past, present and future air quality over Asia. The global CO emissions show a 23% decrease from the years 1980 to 2000. For the future CO (from year 2000 to 2100), the A2 scenario shows a 95% increase due to the B40 (Residential-Biofuel) sector of Western Africa, Eastern Africa and East Asia and the F51 (Transport Road-Fossil fuel) sector of Middle East, USA and South Asia. The B1 scenario, however, shows a 79% decrease of emissions due to B40 and F51 sectors of East Asia, South Asia and USA for the same period. In many cases, Asian emissions play important roles for global emission increase or decrease depending on the IPCC scenarios considered. The regional ozone forming potential will be changed due to different VOC/NOx emission ratio changes in the future. More similarities and differences of Asian emission characteristics, in comparison with its global counterpart, are investigated.

  2. Hydrological Modeling in Northern Tunisia with Regional Climate Model Outputs: Performance Evaluation and Bias-Correction in Present Climate Conditions

    Directory of Open Access Journals (Sweden)

    Asma Foughali

    2015-07-01

    Full Text Available This work aims to evaluate the performance of a hydrological balance model in a watershed located in northern Tunisia (wadi Sejnane, 378 km2 in present climate conditions using input variables provided by four regional climate models. A modified version (MBBH of the lumped and single layer surface model BBH (Bucket with Bottom Hole model, in which pedo-transfer parameters estimated using watershed physiographic characteristics are introduced is adopted to simulate the water balance components. Only two parameters representing respectively the water retention capacity of the soil and the vegetation resistance to evapotranspiration are calibrated using rainfall-runoff data. The evaluation criterions for the MBBH model calibration are: relative bias, mean square error and the ratio of mean actual evapotranspiration to mean potential evapotranspiration. Daily air temperature, rainfall and runoff observations are available from 1960 to 1984. The period 1960–1971 is selected for calibration while the period 1972–1984 is chosen for validation. Air temperature and precipitation series are provided by four regional climate models (DMI, ARP, SMH and ICT from the European program ENSEMBLES, forced by two global climate models (GCM: ECHAM and ARPEGE. The regional climate model outputs (precipitation and air temperature are compared to the observations in terms of statistical distribution. The analysis was performed at the seasonal scale for precipitation. We found out that RCM precipitation must be corrected before being introduced as MBBH inputs. Thus, a non-parametric quantile-quantile bias correction method together with a dry day correction is employed. Finally, simulated runoff generated using corrected precipitation from the regional climate model SMH is found the most acceptable by comparison with runoff simulated using observed precipitation data, to reproduce the temporal variability of mean monthly runoff. The SMH model is the most accurate to

  3. Presentation of the CPR ISMIR (Insulators: IRradiation Modelling); Presentation du CPR ISMIR (ISolants: modelisation de l'IRradiation)

    Energy Technology Data Exchange (ETDEWEB)

    Lozes, G. [CEA Saclay, Dir. de l' Energie Nucleaire (DEN/DSOE), 91 - Gif sur Yvette (France)

    2007-07-01

    The CPR ISMIR is a CEA-CNRS program on the behaviour of materials submitted to irradiation; it has been begun to support the applied current research programs on the aging of nuclear fuels, the storage and incineration matrices and the future reactors. Its aim is to contribute to scientifically set up the methods for anticipating the behaviour of ceramic materials under irradiation in using the important development of calculation means. Thus have been developed the basic knowledge and the interactions physics and calculation models at pertinent scales have been elaborated. (O.M.)

  4. Mappings from models presenting topological mass mechanisms to purely topological models

    International Nuclear Information System (INIS)

    Amaral, R.L.P.G.; Costa, J.V.; Bouffon, L.O.; Lemes, V.E.R.

    2004-01-01

    We discuss a class of mappings between the fields of the Cremmer-Sherk and pure BF model in 4D. These mappings are established both with an interactive procedure as well as with an exact mapping procedure. Related equivalencies in 5D and 3D are discussed. (author)

  5. Mappings From Models Presenting Topological Mass Mechanisms to Purely Topological Models

    International Nuclear Information System (INIS)

    Amaral, R.L.P.G.; Costa, J.V.; Ventura, O.S.; Bouffon, L.O.; Lemes, V.E.R.

    2004-01-01

    We discuss a class of mappings between the fields of the Cremmer-Sherk and pure BF model in 4D. These mappings are established both with an iterative procedure as well as with an exact mapping procedure. Related equivalences in 5D and 3D are discussed

  6. Modelling economic losses of historic and present-day high-impact winter storms in Switzerland

    Science.gov (United States)

    Welker, Christoph; Martius, Olivia; Stucki, Peter; Bresch, David; Dierer, Silke; Brönnimann, Stefan

    2015-04-01

    simulate the wind field and related economic impact of both historic and present-day high-impact winter storms in Switzerland since end of the 19th century. Our technique involves the dynamical downscaling of the 20CR to 3 km horizontal resolution using the numerical Weather Research and Forecasting model and the subsequent loss simulation using an open-source impact model. This impact model estimates, for modern economic and social conditions, storm-related economic losses at municipality level, and thus allows a numerical simulation of the impact from both historic and present-day severe winter storms in Switzerland on a relatively fine spatial scale. In this study, we apply the modelling chain to a storm sample of almost 90 high-impact winter storms in Switzerland since 1871, and we are thus able to make a statement of the typical wind and loss patterns of hazardous windstorms in Switzerland. To evaluate our modelling chain, we compare simulated storm losses with insurance loss data for the present-day windstorms "Lothar" and "Joachim" in December 1999 and December 2011, respectively. Our study further includes a range of sensitivity experiments and a discussion of the main sources of uncertainty.

  7. A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome.

    Directory of Open Access Journals (Sweden)

    Phung Khanh Lam

    Full Text Available To identify risk factors and develop a prediction model for the development of profound and recurrent shock amongst children presenting with dengue shock syndrome (DSS.We analyzed data from a prospective cohort of children with DSS recruited at the Paediatric Intensive Care Unit of the Hospital for Tropical Disease in Ho Chi Minh City, Vietnam. The primary endpoint was "profound DSS", defined as ≥2 recurrent shock episodes (for subjects presenting in compensated shock, or ≥1 recurrent shock episodes (for subjects presenting initially with decompensated/hypotensive shock, and/or requirement for inotropic support. Recurrent shock was evaluated as a secondary endpoint. Risk factors were pre-defined clinical and laboratory variables collected at the time of presentation with shock. Prognostic model development was based on logistic regression and compared to several alternative approaches.The analysis population included 1207 children of whom 222 (18% progressed to "profound DSS" and 433 (36% had recurrent shock. Independent risk factors for both endpoints included younger age, earlier presentation, higher pulse rate, higher temperature, higher haematocrit and, for females, worse hemodynamic status at presentation. The final prognostic model for "profound DSS" showed acceptable discrimination (AUC=0.69 for internal validation and calibration and is presented as a simple score-chart.Several risk factors for development of profound or recurrent shock among children presenting with DSS were identified. The score-chart derived from the prognostic models should improve triage and management of children presenting with DSS in dengue-endemic areas.

  8. On a unified presentation of the non-equilibrium two-phase flow models

    International Nuclear Information System (INIS)

    Boure, J.A.

    1975-01-01

    If the various existing one-dimensional two-phase flow models are consistent, they must appear as particular cases of more general models. It is shown that such is the case if, and only if, the mathematical form of the laws of the transfers between the phases is sufficiently general. These transfer laws control the non-equilibrium phenomena. A convenient general model is a particular form of the two-fluid model. This particular form involves three equations and three dependent variables characterizing the mixture, and three equations and three dependent variables characterizing the differences between the phases (slip, thermal non-equilibriums). The mathematical expressions of the transfert terms present in the above equations involve first-order partial derivatives of the dependent variables. The other existing models may be deduced from the general model by making assumptions on the fluid evolution. Several examples are given. The resulting unified presentation of the existing model enables a comparison of the implicit assumptions made in these models on the transfer laws. It is therefore, a useful tool for the appraisal of the existing models and for the development of new models [fr

  9. Advanced Models and Controls for Prediction and Extension of Battery Lifetime (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G.; Pesaran, A.

    2014-02-01

    Predictive models of capacity and power fade must consider a multiplicity of degradation modes experienced by Li-ion batteries in the automotive environment. Lacking accurate models and tests, lifetime uncertainty must presently be absorbed by overdesign and excess warranty costs. To reduce these costs and extend life, degradation models are under development that predict lifetime more accurately and with less test data. The lifetime models provide engineering feedback for cell, pack and system designs and are being incorporated into real-time control strategies.

  10. Presenting Thin Media Models Affects Women's Choice of Diet or Normal Snacks

    Science.gov (United States)

    Krahe, Barbara; Krause, Christina

    2010-01-01

    Our study explored the influence of thin- versus normal-size media models and of self-reported restrained eating behavior on women's observed snacking behavior. Fifty female undergraduates saw a set of advertisements for beauty products showing either thin or computer-altered normal-size female models, allegedly as part of a study on effective…

  11. Present-Day Mars' Seismicity Predicted From 3-D Thermal Evolution Models of Interior Dynamics

    Science.gov (United States)

    Plesa, A.-C.; Knapmeyer, M.; Golombek, M. P.; Breuer, D.; Grott, M.; Kawamura, T.; Lognonné, P.; Tosi, N.; Weber, R. C.

    2018-03-01

    The Interior Exploration using Seismic Investigations, Geodesy and Heat Transport mission, to be launched in 2018, will perform a comprehensive geophysical investigation of Mars in situ. The Seismic Experiment for Interior Structure package aims to detect global and regional seismic events and in turn offer constraints on core size, crustal thickness, and core, mantle, and crustal composition. In this study, we estimate the present-day amount and distribution of seismicity using 3-D numerical thermal evolution models of Mars, taking into account contributions from convective stresses as well as from stresses associated with cooling and planetary contraction. Defining the seismogenic lithosphere by an isotherm and assuming two end-member cases of 573 K and the 1073 K, we determine the seismogenic lithosphere thickness. Assuming a seismic efficiency between 0.025 and 1, this thickness is used to estimate the total annual seismic moment budget, and our models show values between 5.7 × 1016 and 3.9 × 1019 Nm.

  12. Presenting Numerical Modelling of Explosive Volcanic Eruption to a General Public

    Science.gov (United States)

    Demaria, C.; Todesco, M.; Neri, A.; Blasi, G.

    2001-12-01

    Numerical modeling of explosive volcanic eruptions has been widely applied, during the last decades, to study pyroclastic flows dispersion along volcano's flanks and to evaluate their impact on urban areas. Results from these transient multi-phase and multi-component simulations are often reproduced in form of computer animations, representing the spatial and temporal evolution of relevant flow variables (such as temperature, or particle concentration). Despite being a sophisticated, technical tool to analyze and share modeling results within the scientific community, these animations truly look like colorful cartoons showing an erupting volcano and are especially suited to be shown to a general public. Thanks to their particular appeal, and to the large interest usually risen by exploding volcanoes, these animations have been presented several times on television and magazines and are currently displayed in a permanent exposition, at the Vesuvius Observatory in Naples. This work represents an effort to produce an accompanying tool for these animations, capable of explaining to a large audience the scientific meaning of what can otherwise look as a graphical exercise. Dealing with research aimed at the study of dangerous, explosive volcanoes, improving the general understanding of these scientific results plays an important role as far as risk perception is concerned. An educated population has better chances to follow an appropriate behavior, i.e.: one that could lead, on the long period, to a reduction of the potential risk. In this sense, a correct divulgation of scientific results, while improving the confidence of the population in the scientific community, should belong to the strategies adopted to mitigate volcanic risk. Due to the relevance of the long term final goal of such divulgation experiment, this work represents an interdisciplinary effort, combining scientific expertise and specific competence from the modern communication science and risk

  13. Buddleja thyrsoides Lam. crude extract presents antinociceptive effect on an arthritic pain model in mice.

    Science.gov (United States)

    Fialho, Maria Fernanda Pessano; Brusco, Indiara; da Silva Brum, Evelyne; Piana, Mariana; Boligon, Aline Augusti; Trevisan, Gabriela; Oliveira, Sara Marchesan

    2017-08-17

    Arthritis is a chronic inflammatory disease which reduces the life quality of affected individuals. Therapeutic tools used for treating inflammatory pain are associated with several undesirable effects. Buddleja thyrsoides Lam., known as 'Barbasco' or 'Cambara', is mostly used in several disorders and possesses antirheumatic, anti-inflammatory, and analgesic properties. Here, we investigated the antinociceptive and anti-inflammatory effects of the B. thyrsoides crude extract applied orally and topically in acute pain models and an arthritic pain model induced by complete Freund's adjuvant (CFA) paw injection in male mice (25-30 g). The high-performance liquid chromatography (HPLC) of the B. thyrsoides extract crude revealed the presence of the lupeol, stigmasterol, and β-sitosterol. The stability study of the B. thyrsoides gel did not show relevant changes at low temperatures. The oral treatment with the B. thrysoides extract prevented the capsaicin-induced spontaneous nociception and the acetic acid-induced abdominal writhing, but did not alter the thermal threshold in the tail immersion test. The B. thyrsoides antinociceptive effect was not reversed by naloxone in the capsaicin test. The B. thyrsoides oral or topical treatment reversed the CFA-induced mechanical allodynia and thermal hyperalgesia with maximum inhibition ( I max ) of 69 ± 6 and 68 ± 5% as well as 78 ± 15 and 87 ± 12%, respectively. Moreover, the topical but not oral treatment inhibited the CFA-induced cell infiltration, but did not reduce the paw edema significantly. The oral treatment with B. thyrsoides did not cause adverse effects. These findings suggest that the oral or topical treatment with B. thyrsoides presents antinociceptive actions in an arthritic pain model without causing adverse effects. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

  14. The oral case presentation: toward a performance-based rhetorical model for teaching and learning

    Directory of Open Access Journals (Sweden)

    Mei Yuit Chan

    2015-07-01

    Full Text Available The oral case presentation is an important communicative activity in the teaching and assessment of students. Despite its importance, not much attention has been paid to providing support for teachers to teach this difficult task to medical students who are novices to this form of communication. As a formalized piece of talk that takes a regularized form and used for a specific communicative goal, the case presentation is regarded as a rhetorical activity and awareness of its rhetorical and linguistic characteristics should be given due consideration in teaching. This paper reviews practitioners’ and the limited research literature that relates to expectations of medical educators about what makes a good case presentation, and explains the rhetorical aspect of the activity. It is found there is currently a lack of a comprehensive model of the case presentation that projects the rhetorical and linguistic skills needed to produce and deliver a good presentation. Attempts to describe the structure of the case presentation have used predominantly opinion-based methodologies. In this paper, I argue for a performance-based model that would not only allow a description of the rhetorical structure of the oral case presentation, but also enable a systematic examination of the tacit genre knowledge that differentiates the expert from the novice. Such a model will be a useful resource for medical educators to provide more structured feedback and teaching support to medical students in learning this important genre.

  15. The oral case presentation: toward a performance-based rhetorical model for teaching and learning

    Science.gov (United States)

    Chan, Mei Yuit

    2015-01-01

    The oral case presentation is an important communicative activity in the teaching and assessment of students. Despite its importance, not much attention has been paid to providing support for teachers to teach this difficult task to medical students who are novices to this form of communication. As a formalized piece of talk that takes a regularized form and used for a specific communicative goal, the case presentation is regarded as a rhetorical activity and awareness of its rhetorical and linguistic characteristics should be given due consideration in teaching. This paper reviews practitioners’ and the limited research literature that relates to expectations of medical educators about what makes a good case presentation, and explains the rhetorical aspect of the activity. It is found there is currently a lack of a comprehensive model of the case presentation that projects the rhetorical and linguistic skills needed to produce and deliver a good presentation. Attempts to describe the structure of the case presentation have used predominantly opinion-based methodologies. In this paper, I argue for a performance-based model that would not only allow a description of the rhetorical structure of the oral case presentation, but also enable a systematic examination of the tacit genre knowledge that differentiates the expert from the novice. Such a model will be a useful resource for medical educators to provide more structured feedback and teaching support to medical students in learning this important genre. PMID:26194482

  16. Mathematical study of mixing models

    International Nuclear Information System (INIS)

    Lagoutiere, F.; Despres, B.

    1999-01-01

    This report presents the construction and the study of a class of models that describe the behavior of compressible and non-reactive Eulerian fluid mixtures. Mixture models can have two different applications. Either they are used to describe physical mixtures, in the case of a true zone of extensive mixing (but then this modelization is incomplete and must be considered only as a point of departure for the elaboration of models of mixtures actually relevant). Either they are used to solve the problem of the numerical mixture. This problem appears during the discretization of an interface which separates fluids having laws of different state: the zone of numerical mixing is the set of meshes which cover the interface. The attention is focused on numerical mixtures, for which the hypothesis of non-miscibility (physics) will bring two equations (the sixth and the eighth of the system). It is important to emphasize that even in the case of the only numerical mixture, the presence in one and same place (same mesh) of several fluids have to be taken into account. This will be formalized by the possibility for mass fractions to take all values between 0 and 1. This is not at odds with the equations that derive from the hypothesis of non-miscibility. One way of looking at things is to consider that there are two scales of observation: the physical scale at which one observes the separation of fluids, and the numerical scale, given by the fineness of the mesh, to which a mixture appears. In this work, mixtures are considered from the mathematical angle (both in the elaboration phase and during their study). In particular, Chapter 5 shows a result of model degeneration for a non-extended mixing zone (case of an interface): this justifies the use of models in the case of numerical mixing. All these models are based on the classical model of non-viscous compressible fluids recalled in Chapter 2. In Chapter 3, the central point of the elaboration of the class of models is

  17. Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS) Users' Workshop Presentations

    Science.gov (United States)

    Litt, Jonathan S. (Compiler)

    2018-01-01

    NASA Glenn Research Center hosted a Users' Workshop on the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS) on August 21, 2017. The objective of this workshop was to update the user community on the latest features of T-MATS, and to provide a forum to present work performed using T-MATS. Presentations highlighted creative applications and the development of new features and libraries, and emphasized the flexibility and simulation power of T-MATS.

  18. Proceedings of standard model at the energy of present and future accelerators

    International Nuclear Information System (INIS)

    Csikor, F.; Pocsik, G.; Toth, E.

    1992-01-01

    This book contains the proceedings of the Workshop on The Standard Model at the Energy of the Present and Future Accelerators, 27 June - 1 July 1989, Budapest. The Standard Model of strong and electro-weak interactions providing essential insights into the fundamental structure of matter and being the basic building block of further generalizations has a rich content. The Workshop was devoted to discussing topical problems of testing the Standard Model in high energy reactions such as jet physics and fragmentation, new applications and tests of perturbative QCD, CP-violation, B-meson physics and developments in weak decays, some of the future experimental plans and related topics

  19. Genesis and evolution of the Skyrme model from 1954 to the present

    International Nuclear Information System (INIS)

    Sanyuk, V.I.

    1994-01-01

    Not widely known facts on the genesis of the Skyrme model are presented in a historical survey, based on Skyrme's earliest papers and on his own published remembrance. We consider the evolution of Skyrme's model description of nuclear matter from the ''Mesonic Fluid'' model up to its final version, known as the baryon model. We pay special tribute to some well-known ideas in contemporary particle physics which one can find in Skyrme's earlier papers, such as: Nuclear Democracy, the Solitonic Mechanism, the Nonlinear Realization of Chiral Symmetry, Topological Charges, Fermi-Bose Transmutation, etc. It is curious to note in the final version of the Skyrme model gleams of Kelvin's ''Vortex Atoms'' theory. In conclusion we make a brief analysis of the validity of Skyrme's conjectures in view of recent results and pinpoint some questions which still remain. (author). 93 refs, 4 figs

  20. Linear regression metamodeling as a tool to summarize and present simulation model results.

    Science.gov (United States)

    Jalal, Hawre; Dowd, Bryan; Sainfort, François; Kuntz, Karen M

    2013-10-01

    Modelers lack a tool to systematically and clearly present complex model results, including those from sensitivity analyses. The objective was to propose linear regression metamodeling as a tool to increase transparency of decision analytic models and better communicate their results. We used a simplified cancer cure model to demonstrate our approach. The model computed the lifetime cost and benefit of 3 treatment options for cancer patients. We simulated 10,000 cohorts in a probabilistic sensitivity analysis (PSA) and regressed the model outcomes on the standardized input parameter values in a set of regression analyses. We used the regression coefficients to describe measures of sensitivity analyses, including threshold and parameter sensitivity analyses. We also compared the results of the PSA to deterministic full-factorial and one-factor-at-a-time designs. The regression intercept represented the estimated base-case outcome, and the other coefficients described the relative parameter uncertainty in the model. We defined simple relationships that compute the average and incremental net benefit of each intervention. Metamodeling produced outputs similar to traditional deterministic 1-way or 2-way sensitivity analyses but was more reliable since it used all parameter values. Linear regression metamodeling is a simple, yet powerful, tool that can assist modelers in communicating model characteristics and sensitivity analyses.

  1. Encoding instructions and stimulus presentation in local environmental context-dependent memory studies.

    Science.gov (United States)

    Markopoulos, G; Rutherford, A; Cairns, C; Green, J

    2010-08-01

    Murnane and Phelps (1993) recommend word pair presentations in local environmental context (EC) studies to prevent associations being formed between successively presented items and their ECs and a consequent reduction in the EC effect. Two experiments were conducted to assess the veracity of this assumption. In Experiment 1, participants memorised single words or word pairs, or categorised them as natural or man made. Their free recall protocols were examined to assess any associations established between successively presented items. Fewest associations were observed when the item-specific encoding task (i.e., natural or man made categorisation of word referents) was applied to single words. These findings were examined further in Experiment 2, where the influence of encoding instructions and stimulus presentation on local EC dependent recognition memory was examined. Consistent with recognition dual-process signal detection model predictions and findings (e.g., Macken, 2002; Parks & Yonelinas, 2008), recollection sensitivity, but not familiarity sensitivity, was found to be local EC dependent. However, local EC dependent recognition was observed only after item-specific encoding instructions, irrespective of stimulus presentation. These findings and the existing literature suggest that the use of single word presentations and item-specific encoding enhances local EC dependent recognition.

  2. Lake Michigan lake trout PCB model forecast post audit (oral presentation)

    Science.gov (United States)

    Scenario forecasts for total PCBs in Lake Michigan (LM) lake trout were conducted using the linked LM2-Toxics and LM Food Chain models, supported by a suite of additional LM models. Efforts were conducted under the Lake Michigan Mass Balance Study and the post audit represents an...

  3. Mobile Applications in Cell Biology Present New Approaches for Cell Modelling

    Science.gov (United States)

    de Oliveira, Mayara Lustosa; Galembeck, Eduardo

    2016-01-01

    Cell biology apps were surveyed in order to identify whether there are new approaches for modelling cells allowed by the new technologies implemented in tablets and smartphones. A total of 97 apps were identified in 3 stores surveyed (Apple, Google Play and Amazon), they are presented as: education 48.4%, games 26.8% and medicine 15.4%. The apps…

  4. The effect of PLS regression in PLS path model estimation when multicollinearity is present

    DEFF Research Database (Denmark)

    Nielsen, Rikke; Kristensen, Kai; Eskildsen, Jacob

    PLS path modelling has previously been found to be robust to multicollinearity both between latent variables and between manifest variables of a common latent variable (see e.g. Cassel et al. (1999), Kristensen, Eskildsen (2005), Westlund et al. (2008)). However, most of the studies investigate...... models with relatively few variables and very simple dependence structures compared to the models that are often estimated in practical settings. A recent study by Nielsen et al. (2009) found that when model structure is more complex, PLS path modelling is not as robust to multicollinearity between...... latent variables as previously assumed. A difference in the standard error of path coefficients of as much as 83% was found between moderate and severe levels of multicollinearity. Large differences were found not only for large path coefficients, but also for small path coefficients and in some cases...

  5. Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study.

    Science.gov (United States)

    MacLennan, Calman A; Msefula, Chisomo L; Gondwe, Esther N; Gilchrist, James J; Pensulo, Paul; Mandala, Wilson L; Mwimaniwa, Grace; Banda, Meraby; Kenny, Julia; Wilson, Lorna K; Phiri, Amos; MacLennan, Jenny M; Molyneux, Elizabeth M; Molyneux, Malcolm E; Graham, Stephen M

    2017-12-01

    Nontyphoidal Salmonellae commonly cause invasive disease in African children that is often fatal. The clinical diagnosis of these infections is hampered by the absence of a clear clinical syndrome. Drug resistance means that empirical antibiotic therapy is often ineffective and currently no vaccine is available. The study objective was to identify risk factors for mortality among children presenting to hospital with invasive Salmonella disease in Africa. We conducted a prospective study enrolling consecutive children with microbiologically-confirmed invasive Salmonella disease admitted to Queen Elizabeth Central Hospital, Blantyre, in 2006. Data on clinical presentation, co-morbidities and outcome were used to identify children at risk of inpatient mortality through logistic-regression modeling. Over one calendar year, 263 consecutive children presented with invasive Salmonella disease. Median age was 16 months (range 0-15 years) and 52/256 children (20%; 95%CI 15-25%) died. Nontyphoidal serovars caused 248/263 (94%) of cases. 211/259 (81%) of isolates were multi-drug resistant. 251/263 children presented with bacteremia, 6 with meningitis and 6 with both. Respiratory symptoms were present in 184/240 (77%; 95%CI 71-82%), 123/240 (51%; 95%CI 45-58%) had gastrointestinal symptoms and 101/240 (42%; 95%CI 36-49%) had an overlapping clinical syndrome. Presentation at Salmonella disease in Malawi is characterized by high mortality and prevalence of multi-drug resistant isolates, along with non-specific presentation. Young infants, children with dyspnea and HIV-infected children bear a disproportionate burden of the Salmonella-associated mortality in Malawi. Strategies to improve prevention, diagnosis and management of invasive Salmonella disease should be targeted at these children.

  6. Mass gathering medicine: a predictive model for patient presentation and transport rates.

    Science.gov (United States)

    Arbon, P; Bridgewater, F H; Smith, C

    2001-01-01

    This paper reports on research into the influence of environmental factors (including crowd size, temperature, humidity, and venue type) on the number of patients and the patient problems presenting to first-aid services at large, public events in Australia. Regression models were developed to predict rates of patient presentation and of transportation-to-a-hospital for future mass gatherings. To develop a data set and predictive model that can be applied across venues and types of mass gathering events that is not venue or event specific. Data collected will allow informed event planning for future mass gatherings for which health care services are required. Mass gatherings were defined as public events attended by in excess of 25,000 people. Over a period of 12 months, 201 mass gatherings attended by a combined audience in excess of 12 million people were surveyed throughout Australia. The survey was undertaken by St. John Ambulance Australia personnel. The researchers collected data on the incidence and type of patients presenting for treatment and on the environmental factors that may influence these presentations. A standard reporting format and definition of event geography was employed to overcome the event-specific nature of many previous surveys. There are 11,956 patients in the sample. The patient presentation rate across all event types was 0.992/1,000 attendees, and the transportation-to-hospital rate was 0.027/1,000 persons in attendance. The rates of patient presentations declined slightly as crowd sizes increased. The weather (particularly the relative humidity) was related positively to an increase in the rates of presentations. Other factors that influenced the number and type of patients presenting were the mobility of the crowd, the availability of alcohol, the event being enclosed by a boundary, and the number of patient-care personnel on duty. Three regression models were developed to predict presentation rates at future events. Several

  7. Being present in action: a theoretical model about the interlocking between intentions and environmental affordances

    Directory of Open Access Journals (Sweden)

    Stefano eTriberti

    2016-01-01

    Full Text Available Recent neuropsychological evidence suggest that a key role in linking perceptions and intentions is played by sense of presence. Despite this phenomenon having been studied primarily in the field of virtual reality (conceived as the illusion of being in the virtual space, recent research highlighted that it is a fundamental feature of everyday experience. Specifically, the function of presence as a cognitive process is to locate the Self in a physical space or situation, based on the perceived possibility to act in it; so, the variations in sense of presence allow one to continuously adapt his own action to the external environment. Indeed intentions, as the cognitive antecedents of action, are not static representations of the desired outcomes, but dynamic processes able to adjust their own representational content according to the opportunities/restrictions emerging in the environment. Focusing on the peculiar context of action mediated by interactive technologies, we here propose a theoretical model showing how each level of an intentional hierarchy (future-directed; present directed; and motor intentions can interlock with environmental affordances in order to promote a continuous stream of action and activity.

  8. Novel Threadlike Structures May Be Present on the Large Animal Organ Surface: Evidence in Swine Model

    Directory of Open Access Journals (Sweden)

    Kyoung-Hee Bae

    2013-01-01

    Full Text Available Background. The types of embryonic development probably provoke different paths of novel threadlike structure (NTS development. The authors hypothesized that NTS may be easily observed on the surface of swine intestines by using trypan blue staining method and visualization under an optical microscope. Methods. General anesthesia was administered to 2 Yorkshire pigs. The abdominal walls of the pigs were carefully dissected along the medial alba. NTSs were identified on organ surfaces under a stereoscopic microscope after trypan blue staining. Isolated NTS specimens obtained from the large intestine were subjected to 4′,6-diamidino-2-phenylindole (DAPI staining and observed using the polarized light microscopy to confirm whether the obtained structure fits the definition of NTS. Results. We found elastic, semitransparent threadlike structures (forming a network structure that had a milky-white color in situ and in vivo in swine large intestines. The samples showed distinct extinction of polarized light at every 90 degrees, and nucleus was shown to be rod shaped by DAPI staining, indicating that they meet the criteria of NTS. Conclusion. We used a swine model to demonstrate that NTS may be present on large animal organ surfaces. Our results may permit similar studies by using human specimens.

  9. Portuguese Familial Hypercholesterolemia Study: presentation of the study and preliminary results.

    Science.gov (United States)

    Bourbon, Mafalda; Rato, Quitéria

    2006-11-01

    Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder caused, in the majority of cases, by a partial or total lack of functional low density lipoprotein receptors (LDLR). Mutations in the LDLR gene lead to increased plasma cholesterol levels, resulting in cholesterol deposition in the arteries, thereby increasing the risk of premature coronary heart disease. The homozygous form of FH is rare but heterozygous FH is common, although underdiagnosed in many populations, including the Portuguese. In 1999 the Portuguese Familial Hypercholesterolemia Study was begun at the National Institute of Health. The aim of the Portuguese Familial H ypercholesterolemia Study is to perform an epidemiological study to determine the prevalence and distribution of FH in Portugal and to better understand the pathophysiology of coronary heart disease in these patients. The aim of the present work is to present the study's criteria and organization as well as its preliminary results. The study population consists of individuals of both sexes and all ages with a clinical diagnosis of FH, with biochemical and molecular characterization being performed. The clinical criteria used for the diagnosis of FH were adapted from those of the Simon Broome Heart Research Trust. The study is organized in five stages: 1. selection of individuals with a clinical diagnosis of FH; 2. completion of a clinical questionnaire and declaration of informed consent; 3. collection of blood samples; 4. biochemical characterization; 5. molecular study of three genes associated with the FH phenotype: LDLR, apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9). Between 1999 and June 2006 the LDLR gene and the APOB gene of 141 index cases (38 children and 103 adults) were studied. In 78 of these index cases (76 heterozygotes and two homozygotes) 50 different mutations in the LDLR gene were identified, and two unrelated individuals were found to have the ApoB3500 mutation

  10. Presentation on the Modeling and Educational Demonstrations Laboratory Curriculum Materials Center (MEDL-CMC): A Working Model and Progress Report

    Science.gov (United States)

    Glesener, G. B.; Vican, L.

    2015-12-01

    Physical analog models and demonstrations can be effective educational tools for helping instructors teach abstract concepts in the Earth, planetary, and space sciences. Reducing the learning challenges for students using physical analog models and demonstrations, however, can often increase instructors' workload and budget because the cost and time needed to produce and maintain such curriculum materials is substantial. First, this presentation describes a working model for the Modeling and Educational Demonstrations Laboratory Curriculum Materials Center (MEDL-CMC) to support instructors' use of physical analog models and demonstrations in the science classroom. The working model is based on a combination of instructional resource models developed by the Association of College & Research Libraries and by the Physics Instructional Resource Association. The MEDL-CMC aims to make the curriculum materials available for all science courses and outreach programs within the institution where the MEDL-CMC resides. The sustainability and value of the MEDL-CMC comes from its ability to provide and maintain a variety of physical analog models and demonstrations in a wide range of science disciplines. Second, the presentation then reports on the development, progress, and future of the MEDL-CMC at the University of California Los Angeles (UCLA). Development of the UCLA MEDL-CMC was funded by a grant from UCLA's Office of Instructional Development and is supported by the Department of Earth, Planetary, and Space Sciences. Other UCLA science departments have recently shown interest in the UCLA MEDL-CMC services, and therefore, preparations are currently underway to increase our capacity for providing interdepartmental service. The presentation concludes with recommendations and suggestions for other institutions that wish to start their own MEDL-CMC in order to increase educational effectiveness and decrease instructor workload. We welcome an interuniversity collaboration to

  11. The radiation performance standard. A presentation model for ionizing radiation in the living environment

    International Nuclear Information System (INIS)

    Schaap, L.E.J.J.; Bosmans, G.; Van der Graaf, E.R.; Hendriks, Ch.F.

    1998-01-01

    By means of the so-called radiation performance standard (SPN, abbreviated in Dutch) the total radioactivity from building constructions which contributes to the indoor radiation dose can be calculated. The SPN is implemented with related boundary values and is part of the Building Decree ('Bouwbesluit') in the Netherlands. The model, presented in this book, forms the basis of a new Dutch radiation protection standard, to be published by the Dutch Institute for Standardization NEN (formerly NNI). 14 refs

  12. Simulation of the present-day climate with the climate model INMCM5

    Science.gov (United States)

    Volodin, E. M.; Mortikov, E. V.; Kostrykin, S. V.; Galin, V. Ya.; Lykossov, V. N.; Gritsun, A. S.; Diansky, N. A.; Gusev, A. V.; Iakovlev, N. G.

    2017-12-01

    In this paper we present the fifth generation of the INMCM climate model that is being developed at the Institute of Numerical Mathematics of the Russian Academy of Sciences (INMCM5). The most important changes with respect to the previous version (INMCM4) were made in the atmospheric component of the model. Its vertical resolution was increased to resolve the upper stratosphere and the lower mesosphere. A more sophisticated parameterization of condensation and cloudiness formation was introduced as well. An aerosol module was incorporated into the model. The upgraded oceanic component has a modified dynamical core optimized for better implementation on parallel computers and has two times higher resolution in both horizontal directions. Analysis of the present-day climatology of the INMCM5 (based on the data of historical run for 1979-2005) shows moderate improvements in reproduction of basic circulation characteristics with respect to the previous version. Biases in the near-surface temperature and precipitation are slightly reduced compared with INMCM4 as well as biases in oceanic temperature, salinity and sea surface height. The most notable improvement over INMCM4 is the capability of the new model to reproduce the equatorial stratospheric quasi-biannual oscillation and statistics of sudden stratospheric warmings.

  13. Introducing WISDEM:An Integrated System Modeling for Wind Turbines and Plant (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Dykes, K.; Graf, P.; Scott, G.; Ning, A.; King, R.; Guo, Y.; Parsons, T.; Damiani, R.; Felker, F.; Veers, P.

    2015-01-01

    The National Wind Technology Center wind energy systems engineering initiative has developed an analysis platform to leverage its research capabilities toward integrating wind energy engineering and cost models across wind plants. This Wind-Plant Integrated System Design & Engineering Model (WISDEM) platform captures the important interactions between various subsystems to achieve a better National Wind Technology Center wind energy systems engineering initiative has developed an analysis platform to leverage its research capabilities toward integrating wind energy engineering and cost models across wind plants. This Wind-Plant Integrated System Design & Engineering Model (WISDEM) platform captures the important interactions between various subsystems to achieve a better understanding of how to improve system-level performance and achieve system-level cost reductions. This work illustrates a few case studies with WISDEM that focus on the design and analysis of wind turbines and plants at different system levels.

  14. Studies on DANESS Code Modeling

    International Nuclear Information System (INIS)

    Jeong, Chang Joon

    2009-09-01

    The DANESS code modeling study has been performed. DANESS code is widely used in a dynamic fuel cycle analysis. Korea Atomic Energy Research Institute (KAERI) has used the DANESS code for the Korean national nuclear fuel cycle scenario analysis. In this report, the important models such as Energy-demand scenario model, New Reactor Capacity Decision Model, Reactor and Fuel Cycle Facility History Model, and Fuel Cycle Model are investigated. And, some models in the interface module are refined and inserted for Korean nuclear fuel cycle model. Some application studies have also been performed for GNEP cases and for US fast reactor scenarios with various conversion ratios

  15. Differential levels of brain amino acids in rat models presenting learned helplessness or non-learned helplessness.

    Science.gov (United States)

    Muneoka, Katsumasa; Shirayama, Yukihiko; Horio, Mao; Iyo, Masaomi; Hashimoto, Kenji

    2013-09-01

    Glutamatergic and γ-aminobutyric acid (GABA)ergic abnormalities have recently been proposed to contribute to depression. The learned helplessness (LH) paradigm produces a reliable animal model of depression that expresses a deficit in escape behavior (LH model); an alternative phenotype that does not exhibit LH is a model of resilience to depression (non-LH model). We measured the contents of amino acids in the brain to investigate the mechanisms involved in the pathology of depression. LH and non-LH models were subjected to inescapable electric footshocks at random intervals following a conditioned avoidance test to determine acquirement of predicted escape deficits. Tissue amino acid contents in eight brain regions were measured via high-performance liquid chromatography. The non-LH model showed increased GABA levels in the dentate gyrus and nucleus accumbens and increased glutamine levels in the dentate gyrus and the orbitofrontal cortex. The LH model had reduced glutamine levels in the medial prefrontal cortex. Changes in the ratios of GABA, glutamine, and glutamate were detected in the non-LH model, but not in the LH model. Reductions in threonine levels occurred in the medial prefrontal cortex in both models, whereas elevated alanine levels were detected in the medial prefrontal cortex in non-LH animals. The present study demonstrates region-specific compensatory elevations in GABA levels in the dentate gyrus and nucleus accumbens of non-LH animals, supporting the implication of the GABAergic system in the recovery of depression.

  16. The Relationship between Spiritual Health and other Dimensions of Health: Presentation of a Model

    Directory of Open Access Journals (Sweden)

    Akram Heidari

    2016-06-01

    Full Text Available Attitudes to humankind will have different effects on health service delivery. Health might used to be intended to provide physical health in the past; today, however, many researchers and clinicians consider the concept health to be beyond physical health. In support of this claim, it is enough to indicate that the bio-psycho-social model has for years been held by scientific communities to be a fully admitted model. However, the missing ring in this model, as suggested by many, is the spiritual health. In recent years, the relationship between spirituality and clinical interventions with a comprehensive focus on health has been under increasing scrutiny. Although different models have been presented for investigation of the relationship between spiritual health and other dimensions, the fundamental challenge in this regard is the actual place of spiritual health compared with other dimensions. In this article, attempts are made to address the position and weight of spiritual health from the Islam’s point of view.

  17. International Symposium on Isotopes in Hydrology, Marine Ecosystems, and Climate Change Studies. Presentations

    International Nuclear Information System (INIS)

    2011-01-01

    Human activities have had a far-reaching impact on the aquatic environments - both marine and freshwater systems. The protection of these systems against further deterioration and the promotion of sustainable use are vital. In order to deepen understanding about the main processes affecting the present situation, as well as possible developments in the future, further investigation is required. The oceans play a major role in climate change, for example, and ocean acidification by increased CO2 release is one major threat to the world's oceans. Isotope methods can play a critical role in identifying and quantifying key processes within aquatic environments. Addressing the problems of global water resources has become a matter of urgency. Water resources are subject to multiple pressures for various reasons, including increasing populations, climate change, rising food and energy costs, the global economic crisis and pollutant loading. Isotope hydrology provides the unique and critical tools required to address complex water problems and helps managers and policy makers understand the closely intertwined relationship between water resources and the various pressures affecting them, as well as the issue of sustainability. The symposium will be an important forum for the exchange of knowledge on the present state of marine and freshwater environments, use of isotopes in water resources investigations and management, and climate change studies. The meeting will involve leading scientists in the field of climate change and hydrology, as well as representatives from other United Nations bodies and international organizations that focus on climate change and other important environmental issues. TOPICS: The role of isotopes in understanding and modelling climate change, marine ecosystems and the water cycle; Carbon dioxide sequestration and related aspects of the carbon cycle, such as ocean acidification; Isotopes in groundwater flow modelling for large aquifers

  18. Beyond the standard Higgs at the LHC. Present constraints on little Higgs models and future prospects

    International Nuclear Information System (INIS)

    Tonini, Marco

    2014-11-01

    This thesis discusses the consistency of different Little Higgs models with the collected collider data as of the summer of 2013. Moreover, future prospects for possible discoveries and mass measurement methods of new physics signals at the foreseen LHC run II with increased center-of-mass energy are presented. Little Higgs models belong to a class of extensions of the Standard Higgs model, predicting a strong interaction regime at a compositeness scale Λ=4πf approximate global symmetry spontaneously broken at the scale f. A natural hierarchy between the compositeness and the electroweak scale is introduced by the Collective Symmetry Breaking mechanism: one-loop diagrams generating the Higgs mass term are forced to be at most logarithmically sensitive to Λ. A naturally light Higgs boson can thus be accommodated, consistently with a perturbative theory until a scale of order 10 TeV. We have probed the parameter space of three prominent examples of Little Higgs models, namely the Simplest Little Higgs model, the Littlest Higgs model, and the Littlest Higgs model with T-parity, against electroweak precision observables and the collected LHC data concerning both Higgs properties and direct searches for new particles, with √(s)=7,8 TeV and up to 25 fb -1 of integrated luminosity. Lower bounds on the scale f are set, within a certain degree of confidence level, which allow to draw conclusions on the ''naturalness'' of the different models. Optimisations of the existing direct searches setups, assuming a Little Higgs signal, as well as dedicated mass measurement methods designed for the foreseen LHC runs with √(s)=13,14 TeV are thoroughly discussed and proposed in this thesis. Special attention will be dedicated to final states including either a large or negligible fraction of missing transverse momentum. In particular, we will propose a dedicated collider search tailored for the discovery and mass measurement of a top partner, exploiting jet

  19. Modeling the Activities of Scientists: Prospective Science Teachers' Poster Presentations in An STS Course

    Science.gov (United States)

    Dogan, Alev; Kaya, Osman Nafiz; Kilic, Ziya; Kilic, Esma; Aydogdu, Mustafa

    2004-01-01

    In this study, prospective science teachers' (PSTs) views about their poster presentations were investigated. These posters were developed through PSTs' online and library research and scientific mini-symposiums in chemistry related topics in the framework of science, technology and society course (STS). During the first four weeks of STS course,…

  20. The Effect of Google Earth and Wiki Models on Oral Presentation Skills of University EFL Learners

    Science.gov (United States)

    Awada, Ghada; Diab, Hassan B.

    2018-01-01

    This article reports the results of an experimental study that investigated the effectiveness of Google Earth and Wiki tools in improving the oral presentation skills of English as a Foreign Language (EFL) learners and boosting their motivation for learning. The participants (n =81) are enrolled in writing classes at two English-medium…

  1. In vitro three-dimensional cancer metastasis modeling: Past, present, and future

    International Nuclear Information System (INIS)

    Han Wei-jing; Zhu Jiang-rui; Fan Qihui; Liu Li-yu; Yuan Wei; Qu Junle

    2016-01-01

    Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our understanding of the progression of malignancy. However, most of the molecular mechanisms fail to address the causes of cancer and its evolutionary origin, demonstrating an inability to find a solution for complete cure of cancer. After being a neglected area of tumor biology for quite some time, recently several studies have focused on the impact of the tumor microenvironment on cancer growth. The importance of the tumor microenvironment is gradually gaining attention, particularly from the perspective of biophysics. In vitro three-dimensional (3-D) metastatic models are an indispensable platform for investigating the tumor microenvironment, as they mimic the in vivo tumor tissue. In 3-D metastatic in vitro models, static factors such as the mechanical properties, biochemical factors, as well as dynamic factors such as cell–cell, cell–ECM interactions, and fluid shear stress can be studied quantitatively. With increasing focus on basic cancer research and drug development, the in vitro 3-D models offer unique advantages in fundamental and clinical biomedical studies. (topical review)

  2. Creys-Malville nuclear plant. Simulation of the cold plenum thermal-hydraulics. 12 zone model presentation

    International Nuclear Information System (INIS)

    Faulot, J.P.

    1990-05-01

    The CRUSIFI code has been developed by SEPTEN (Engineering and Construction Division) with SICLE software during 1983-1985 in order to study the CREYS-MALVILLE dynamic behavior. At the time, the version was based on project data (version 2.3). It includes a 2 zones model for the cold plenum thermal-hydraulics, modelling which does not allow to reproduce accurately dissymetries apt to occur as well in usual operating (hydraulic dissymetries bound to one or many systems out of order), as during incidentally operating (hydraulic dissymetries bound to primary pump working back or thermal dissymetries after a transient on one or many secondary loops). Moreover, a 2 zones model cannot simulate axial temperature gradients which appear during double stratification phenomenon (upper and lower part of the plenum) produced by alternating thermal shock. A 12 zones model (4 sectors with 3 axial zones each) such as model developed by R$DD (Research and Development Division) allows to satisfy correctly these problems. This report is a specification of the chosen modelling. This model is now operational after qualifying with experimental transients on mockup and reactor. It is to-day connected with the EDF general operating code CRUSIFI (calibrating version 3.0). It could be easily integrated in a four loops plant modelling such as the CREYS-MALVILLE simulator in a four loops plant modelling such as the CREYS-MALVILLE simulator under construction at the present time by THOMSON

  3. Geographical Information System Model for Potential Mines Data Management Presentation in Kabupaten Gorontalo

    Science.gov (United States)

    Roviana, D.; Tajuddin, A.; Edi, S.

    2017-03-01

    Mining potential in Indonesian is very abundant, ranging from Sabang to Marauke. Kabupaten Gorontalo is one of many places in Indonesia that have different types of minerals and natural resources that can be found in every district. The abundant of mining potential must be balanced with good management and ease of getting information by investors. The current issue is, (1) ways of presenting data/information about potential mines area is still manually (the maps that already capture from satellite image, then printed and attached to information board in the office) it caused the difficulties of getting information; (2) the high cost of maps printing; (3) the difficulties of regency leader (bupati) to obtain information for strategic decision making about mining potential. The goal of this research is to build a model of Geographical Information System that could provide data management of potential mines, so that the investors could easily get information according to their needs. To achieve that goal Research and Development method is used. The result of this research, is a model of Geographical Information System that implemented in an application to presenting data management of mines.

  4. Multi-nutrient, multi-group model of present and future oceanic phytoplankton communities

    Directory of Open Access Journals (Sweden)

    E. Litchman

    2006-01-01

    Full Text Available Phytoplankton community composition profoundly affects patterns of nutrient cycling and the dynamics of marine food webs; therefore predicting present and future phytoplankton community structure is crucial to understand how ocean ecosystems respond to physical forcing and nutrient limitations. We develop a mechanistic model of phytoplankton communities that includes multiple taxonomic groups (diatoms, coccolithophores and prasinophytes, nutrients (nitrate, ammonium, phosphate, silicate and iron, light, and a generalist zooplankton grazer. Each taxonomic group was parameterized based on an extensive literature survey. We test the model at two contrasting sites in the modern ocean, the North Atlantic (North Atlantic Bloom Experiment, NABE and subarctic North Pacific (ocean station Papa, OSP. The model successfully predicts general patterns of community composition and succession at both sites: In the North Atlantic, the model predicts a spring diatom bloom, followed by coccolithophore and prasinophyte blooms later in the season. In the North Pacific, the model reproduces the low chlorophyll community dominated by prasinophytes and coccolithophores, with low total biomass variability and high nutrient concentrations throughout the year. Sensitivity analysis revealed that the identity of the most sensitive parameters and the range of acceptable parameters differed between the two sites. We then use the model to predict community reorganization under different global change scenarios: a later onset and extended duration of stratification, with shallower mixed layer depths due to increased greenhouse gas concentrations; increase in deep water nitrogen; decrease in deep water phosphorus and increase or decrease in iron concentration. To estimate uncertainty in our predictions, we used a Monte Carlo sampling of the parameter space where future scenarios were run using parameter combinations that produced acceptable modern day outcomes and the

  5. Using MultiMedia Content to Present Business Ethics: An Empirical Study

    Science.gov (United States)

    Stanwick, Peter A.

    2010-01-01

    The purpose of this study is to empirically examine whether presenting a multimedia case study enhances the learning experience of students in an undergraduate management class. A questionnaire was administered before and after the presentation of the case study and the results showed that the multimedia case did indeed enhance the learning…

  6. Presentation of a model simulating the response of lakes to fertilizations to reduce radiocesium levels in fish

    International Nuclear Information System (INIS)

    Hakanson, L.; Ottosson, F.; Abrahamsson, O.; Johansson, T.

    1998-01-01

    Lake fertilization is a potential remedy for toxic contamination in lakes with low productivity, which are known to be sensitive to, e.g. radionuclides, metals and organic toxins. This study presents a model to plan the duration and predict the outcome of fertilization in lakes. Several methods of lake fertilization have been used in field experiments: (1) Lake and wetland liming using 'mixed' lime with added phosphorus; (2) treatment with commercial fertilizers; and (3) using effluents (containing phosphorus) from fish farms. This model is basically a dynamic model using differential equations to handle fluxes, amounts and concentrations. It also includes several empirical relationships, because the model is meant to be used in practice and the driving variables should be few and readily available, like catchment and lake morphometric data. The model is primarily intended to be used as a sub-model predicting realistic changes in phosphorus and potassium concentrations and in lake pH caused by these remedial measures within the framework of a more extensive lake model for radiocesium. It is, however, meant to be based on the fundamental processes regulating phosphorus fluxes in lakes, and could be of interest also in contexts other than radioecology. It is driven by the amount of fertilizer added to the lake and the month of treatment. The consequences for the spread, biological uptake and concentrations of radiocesium are also discussed and simulated. The phosphorus model is, and must be, easy to handle since all the input data should be derived either from maps or from regular monitoring programs. In this paper, the model is presented and calibrations are examined. The results of the calibrations indicate that the model should be useful for managers to optimise lake fertilization, e.g. in contexts of lake radioecology where the benefits and drawbacks of different remedial strategies are evaluated (multi-attribute analysis). (Copyright (c) 1998 Elsevier Science B

  7. Patients' Experiences of Cancer Diagnosis as a Result of an Emergency Presentation: A Qualitative Study.

    Science.gov (United States)

    Black, Georgia; Sheringham, Jessica; Spencer-Hughes, Vicki; Ridge, Melanie; Lyons, Mairead; Williams, Charlotte; Fulop, Naomi; Pritchard-Jones, Kathy

    2015-01-01

    Cancers diagnosed following visits to emergency departments (ED) or emergency admissions (emergency presentations) are associated with poor survival and may result from preventable diagnostic delay. To improve outcomes for these patients, a better understanding is needed about how emergency presentations arise. This study sought to capture patients' experiences of this diagnostic pathway in the English NHS. Eligible patients were identified in a service evaluation of emergency presentations and invited to participate. Interviews, using an open-ended biographical structure, captured participants' experiences of healthcare services before diagnosis and were analysed thematically, informed by the Walter model of Pathways to Treatment and NICE guidance in an iterative process. Twenty-seven interviews were conducted. Three typologies were identified: A: Rapid investigation and diagnosis, and B: Repeated cycles of healthcare seeking and appraisal without resolution, with two variants where B1 appears consistent with guidance and B2 has evidence that management was not consistent with guidance. Most patients' (23/27) experiences fitted types B1 and B2. Potentially avoidable breakdowns in diagnostic pathways caused delays when patients were conflicted by escalating symptoms and a benign diagnosis given earlier by doctors. ED was sometimes used as a conduit to rapid testing by primary care clinicians, although this pathway was not always successful. This study draws on patients' experiences of their diagnosis to provide novel insights into how emergency presentations arise. Through these typologies, we show that the typical experience of patients diagnosed through an emergency presentation diverges significantly from normative pathways even when there is no evidence of serious service failures. Consultations were not a conduit to diagnosis when they inhibited patients' capacity to appraise their own symptoms appropriately and when they resulted in a reluctance to seek

  8. Modelling microbiological water quality in the Seine river drainage network: past, present and future situations

    Directory of Open Access Journals (Sweden)

    P. Servais

    2007-09-01

    Full Text Available The Seine river watershed is characterized by a high population density and intense agricultural activities. Data show low microbiological water quality in the main rivers (Seine, Marne, Oise of the watershed. Today, there is an increasing pressure from different social groups to restore microbiological water quality in order to both increase the safety of drinking water production and to restore the possible use of these rivers for bathing and rowing activities, as they were in the past. A model, appended to the hydro-ecological SENEQUE/Riverstrahler model describing the functioning of large river systems, was developed to describe the dynamics of faecal coliforms (FC, the most usual faecal contamination indicator. The model is able to calculate the distribution of FC concentrations in the whole drainage network resulting from land use and wastewater management in the watershed. The model was validated by comparing calculated FC concentrations with available field data for some well-documented situations in different river stretches of the Seine drainage network. Once validated, the model was used to test various predictive scenarios, as, for example, the impact of the modifications in wastewater treatment planned at the 2012 horizon in the Seine watershed in the scope of the implementation of the european water framework directive. The model was also used to investigate past situations. In particular, the variations of the microbiological water quality in the Parisian area due to population increase and modifications in wastewater management were estimated over the last century. It was shown that the present standards for bathing and other aquatic recreational activities are not met in the large tributaries upstream from Paris since the middle of the 1950's, and at least since the middle of the XIXth century in the main branch of the Seine river downstream from Paris. Efforts carried out for improving urban wastewater treatment in terms

  9. Geometric modelling of channel present in reservoir petroleum using Bezier splines; Modelagem da geometria de paleocanais presentes em reservatorios petroliferos usando splines de Bezier

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Carlos Eduardo S. [Universidade Federal de Campina Grande, PB (Brazil). Programa de Recursos Humanos 25 da ANP]. E-mail: carlos@dme.ufcg.edu.br; Silva, Rosana M. da [Universidade Federal de Campina Grande, PB (Brazil). Dept. de Matematica e Estatistica]. E-mail: rosana@dme.ufcg.edu.br

    2004-07-01

    This work presents an implementation of a synthetic model of a channel found in oil reservoir. The generation these models is one of the steps to the characterization and simulation of the equal probable three-dimensional geological scenery. O implemented model was obtained from fitting techniques of geometric modeling of curves and surfaces to the geological parameters (width, thickness, sinuosity and preferential direction) that defines the form to be modeled. The parameter sinuosity is related with the parameter wave length and the local amplitude of the channel, the parameter preferential direction indicates the way of the flow and the declivity of the channel. The modeling technique used to represent the surface of the channel is the sweeping technique, the consist in effectuate a translation operation from a curve along a guide curve. The guide curve, in our implementation, was generated by the interpolation of points obtained form sampled values or simulated of the parameter sinuosity, using the cubic splines of Bezier technique. A semi-ellipse, determinate by the parameter width and thickness, representing a transversal section of the channel, is the transferred curve through the guide curve, generating the channel surface. (author)

  10. Crystal study and econometric model

    Science.gov (United States)

    1975-01-01

    An econometric model was developed that can be used to predict demand and supply figures for crystals over a time horizon roughly concurrent with that of NASA's Space Shuttle Program - that is, 1975 through 1990. The model includes an equation to predict the impact on investment in the crystal-growing industry. Actually, two models are presented. The first is a theoretical model which follows rather strictly the standard theoretical economic concepts involved in supply and demand analysis, and a modified version of the model was developed which, though not quite as theoretically sound, was testable utilizing existing data sources.

  11. Investigating the Effective Factors on Entering into International Markets by Presenting the Local Islamic Model

    Directory of Open Access Journals (Sweden)

    Sayyed Mohammad Ali Alamolhodaei

    2015-03-01

    Full Text Available The internationalization of small and medium size businesses is regarded as one of the most leading general policies in many of the world’s countries. The reason is that it is often the small and medium size companies which have a vital role in industrial innovation and gain profit for their societies through economic development. This research has investigated and identified the effective factors (organizational factors and business etiquette in Islam on entering into international markets by presenting local Islamic model in the companies of incubator of Science and Technology Park. The statistical population of the research includes the existing companies of Incubator of Mashhad Science and Technology Park. The statistical sample was investigated through simple random sampling from managers of active companies in export in Science and Technology Park. AMOS and SPSS software were applied for data analysis to identify the effects among variables survey research methodology and questionnaire tools were used.

  12. Barriers to cancer symptom presentation among people from low socioeconomic groups: a qualitative study

    Directory of Open Access Journals (Sweden)

    Grace McCutchan

    2016-10-01

    Full Text Available Abstract Background Socioeconomic inequalities in cancer survival can in part be explained by long patient intervals among people from deprived groups; however, the reasons for this are unclear. This qualitative study explores the actual and anticipated barriers to cancer symptom presentation in the context of socioeconomic deprivation. Methods Thirty participants were recruited through the International Cancer Benchmarking Partnership Welsh database (n = 20, snowball sampling (n = 8 and community partners (n = 2. Semi-structured qualitative interviews were conducted with symptomatic and asymptomatic adults over the age of 50 years, who were identified as being from a low socioeconomic group based on multiple individual and group level indicators. Transcripts were analysed using a Framework approach based on the COM-B model (Capability, Opportunity, Motivation-Behaviour. Results There was evidence of poor awareness of non-specific cancer symptoms (Capability, fearful and fatalistic beliefs about cancer (Motivation, and various barriers to accessing an appointment with the family physician (Opportunity and full disclosure of symptoms (Capability. These in combination were associated with a lengthened patient interval among participants. Social networks (Opportunity were influential on the formation of knowledge and beliefs about cancer. Participants’ behavioural and normative beliefs were usually formed and reinforced by people they knew with cancer, and such beliefs were considered to lengthen the patient interval. Discussing symptoms with a family member or friend before a visit to the family physician was the norm, and could act as a barrier or facilitator depending on the quality of advice given (Opportunity. Economic hardship meant fulfilling basic day-to-day needs such as finding money for food were prioritised over medical help seeking (Opportunity. Conclusions The complex interaction between individual characteristics and

  13. Stroke Mortality, Clinical Presentation and Day of Arrival: The Atherosclerosis Risk in Communities (ARIC Study

    Directory of Open Access Journals (Sweden)

    Emily C. O'Brien

    2011-01-01

    Full Text Available Background. Recent studies report that acute stroke patients who present to the hospital on weekends have higher rates of 28-day mortality than similar patients who arrive during the week. However, how this association is related to clinical presentation and stroke type has not been systematically investigated. Methods and Results. We examined the association between day of arrival and 28-day mortality in 929 validated stroke events in the ARIC cohort from 1987–2004. Weekend arrival was defined as any arrival time from midnight Friday until midnight Sunday. Mortality was defined as all-cause fatal events from the day of arrival through the 28th day of followup. The presence or absence of thirteen stroke signs and symptoms were obtained through medical record review for each event. Binomial logistic regression was used to estimate odds ratios and 95% confidence intervals (OR; 95% CI for the association between weekend arrival and 28-day mortality for all stroke events and for stroke subtypes. The overall risk of 28-day mortality was 9.6% for weekday strokes and 10.1% for weekend strokes. In models controlling for patient demographics, clinical risk factors, and event year, weekend arrival was not associated with 28-day mortality (0.87; 0.51, 1.50. When stratified by stroke type, weekend arrival was not associated with increased odds of mortality for ischemic (1.17, 0.62, 2.23 or hemorrhagic (0.37; 0.11, 1.26 stroke patients. Conclusions. Presence or absence of thirteen signs and symptoms was similar for weekday patients and weekend patients when stratified by stroke type. Weekend arrival was not associated with 28-day all-cause mortality or differences in symptom presentation for strokes in this cohort.

  14. Cloud-based Monte Carlo modelling of BSSRDF for the rendering of human skin appearance (Conference Presentation)

    Science.gov (United States)

    Doronin, Alexander; Rushmeier, Holly E.; Meglinski, Igor; Bykov, Alexander V.

    2016-03-01

    We present a new Monte Carlo based approach for the modelling of Bidirectional Scattering-Surface Reflectance Distribution Function (BSSRDF) for accurate rendering of human skin appearance. The variations of both skin tissues structure and the major chromophores are taken into account correspondingly to the different ethnic and age groups. The computational solution utilizes HTML5, accelerated by the graphics processing units (GPUs), and therefore is convenient for the practical use at the most of modern computer-based devices and operating systems. The results of imitation of human skin reflectance spectra, corresponding skin colours and examples of 3D faces rendering are presented and compared with the results of phantom studies.

  15. Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs.

    Science.gov (United States)

    Löscher, Wolfgang

    2017-07-01

    The identification of potential therapeutic agents for the treatment of epilepsy requires the use of seizure models. Except for some early treatments, including bromides and phenobarbital, the antiseizure activity of all clinically used drugs was, for the most part, defined by acute seizure models in rodents using the maximal electroshock and subcutaneous pentylenetetrazole seizure tests and the electrically kindled rat. Unfortunately, the clinical evidence to date would suggest that none of these models, albeit useful, are likely to identify those therapeutics that will effectively manage patients with drug resistant seizures. Over the last 30 years, a number of animal models have been developed that display varying degrees of pharmacoresistance, such as the phenytoin- or lamotrigine-resistant kindled rat, the 6-Hz mouse model of partial seizures, the intrahippocampal kainate model in mice, or rats in which spontaneous recurrent seizures develops after inducing status epilepticus by chemical or electrical stimulation. As such, these models can be used to study mechanisms of drug resistance and may provide a unique opportunity for identifying a truly novel antiseizure drug (ASD), but thus far clinical evidence for this hope is lacking. Although animal models of drug resistant seizures are now included in ASD discovery approaches such as the ETSP (epilepsy therapy screening program), it is important to note that no single model has been validated for use to identify potential compounds for as yet drug resistant seizures, but rather a battery of such models should be employed, thus enhancing the sensitivity to discover novel, highly effective ASDs. The present review describes the previous and current approaches used in the search for new ASDs and offers some insight into future directions incorporating new and emerging animal models of therapy resistance.

  16. Ecoclimatic indicators to study crop suitability in present and future climatic conditions

    Science.gov (United States)

    Caubel, Julie; Garcia de Cortazar Atauri, Inaki; Huard, Frédéric; Launay, Marie; Ripoche, Dominique; Gouache, David; Bancal, Marie-Odile; Graux, Anne-Isabelle; De Noblet, Nathalie

    2013-04-01

    Climate change is expected to affect both regional and global food production through changes in overall agroclimatic conditions. It is therefore necessary to develop simple tools of crop suitability diagnosis in a given area so that stakeholders can envisage land use adaptations under climate change conditions. The most common way to investigate potential impacts of climate on the evolution of agrosystems is to make use of an array of agroclimatic indicators, which provide synthetic information derived from climatic variables and calculated within fixed periods (i.e. January first - 31th July). However, the information obtained during these periods does not enable to take account of the plant response to climate. In this work, we present some results of the research program ORACLE (Opportunities and Risks of Agrosystems & forests in response to CLimate, socio-economic and policy changEs in France (and Europe). We proposed a suite of relevant ecoclimatic indicators, based on temperature and rainfall, in order to evaluate crop suitability for both present and new climatic conditions. Ecoclimatic indicators are agroclimatic indicators (e.g., grain heat stress) calculated during specific phenological phases so as to take account of the plant response to climate (e.g., the grain filling period, flowering- harvest). These indicators are linked with the ecophysiological processes they characterize (for e.g., the grain filling). To represent this methodology, we studied the suitability of winter wheat in future climatic conditions through three distinct French sites, Toulouse, Dijon and Versailles. Indicators have been calculated using climatic data from 1950 to 2100 simulated by the global climate model ARPEGE forced by a greenhouse effect corresponding to the SRES A1B scenario. The Quantile-Quantile downscaling method was applied to obtain data for the three locations. Phenological stages (emergence, ear 1 cm, flowering, beginning of grain filling and harvest) have been

  17. Ecoclimatic indicators to study crop suitability in present and future climatic conditionsTIC CONDITIONS

    Science.gov (United States)

    Caubel, Julie; Garcia de Cortazar Atauri, Inaki; Huard, Frédéric; Launay, Marie; Ripoche, Dominique; Gouache, David; Bancal, Marie-Odile; Graux, Anne-Isabelle; De Noblet, Nathalie

    2013-04-01

    Climate change is expected to affect both regional and global food production through changes in overall agroclimatic conditions. It is therefore necessary to develop simple tools of crop suitability diagnosis in a given area so that stakeholders can envisage land use adaptations under climate change conditions. The most common way to investigate potential impacts of climate on the evolution of agrosystems is to make use of an array of agroclimatic indicators, which provide synthetic information derived from climatic variables and calculated within fixed periods (i.e. January first - 31th July). However, the information obtained during these periods does not enable to take account of the plant response to climate. In this work, we present some results of the research program ORACLE (Opportunities and Risks of Agrosystems & forests in response to CLimate, socio-economic and policy changEs in France (and Europe). We proposed a suite of relevant ecoclimatic indicators, based on temperature and rainfall, in order to evaluate crop suitability for both present and new climatic conditions. Ecoclimatic indicators are agroclimatic indicators (e.g., grain heat stress) calculated during specific phenological phases so as to take account of the plant response to climate (e.g., the grain filling period, flowering- harvest). These indicators are linked with the ecophysiological processes they characterize (for e.g., the grain filling). To represent this methodology, we studied the suitability of winter wheat in future climatic conditions through three distinct French sites, Toulouse, Dijon and Versailles. Indicators have been calculated using climatic data from 1950 to 2100 simulated by the global climate model ARPEGE forced by a greenhouse effect corresponding to the SRES A1B scenario. The Quantile-Quantile downscaling method was applied to obtain data for the three locations. Phenological stages (emergence, ear 1 cm, flowering, beginning of grain filling and harvest) have been

  18. The effect of study time distribution on learning and retention: a Goldilocks principle for presentation rate.

    Science.gov (United States)

    de Jonge, Mario; Tabbers, Huib K; Pecher, Diane; Zeelenberg, René

    2012-03-01

    In 2 experiments, we investigated the effect of presentation rate on both immediate (5 min) and delayed (2 days) cued recall of paired associates. Word pairs were presented for a total of 16 s per pair, with presentation duration of individual presentations varying from 1 to 16 s. In Experiment 1, participants studied word pairs with presentation rates of 16 × 1 s, 8 × 2 s, 4 × 4 s, 2 × 8 s, or 1 × 16 s. A nonmonotonic relationship was found between presentation rate and cued recall performance. Both short (e.g., 1 s) and long (e.g., 16 s) presentation durations resulted in poor immediate and delayed recall, compared with intermediate presentation durations. In Experiment 2, we replicated these general findings. Moreover, we showed that the 4 s condition resulted in less proportional forgetting than the 1 s and the 16 s conditions. 2012 APA, all rights reserved

  19. Nonlinear modeling of ferroelectric-ferromagnetic composites based on condensed and finite element approaches (Presentation Video)

    Science.gov (United States)

    Ricoeur, Andreas; Lange, Stephan; Avakian, Artjom

    2015-04-01

    Magnetoelectric (ME) coupling is an inherent property of only a few crystals exhibiting very low coupling coefficients at low temperatures. On the other hand, these materials are desirable due to many promising applications, e.g. as efficient data storage devices or medical or geophysical sensors. Efficient coupling of magnetic and electric fields in materials can only be achieved in composite structures. Here, ferromagnetic (FM) and ferroelectric (FE) phases are combined e.g. including FM particles in a FE matrix or embedding fibers of the one phase into a matrix of the other. The ME coupling is then accomplished indirectly via strain fields exploiting magnetostrictive and piezoelectric effects. This requires a poling of the composite, where the structure is exposed to both large magnetic and electric fields. The efficiency of ME coupling will strongly depend on the poling process. Besides the alignment of local polarization and magnetization, it is going along with cracking, also being decisive for the coupling properties. Nonlinear ferroelectric and ferromagnetic constitutive equations have been developed and implemented within the framework of a multifield, two-scale FE approach. The models are microphysically motivated, accounting for domain and Bloch wall motions. A second, so called condensed approach is presented which doesn't require the implementation of a spatial discretisation scheme, however still considering grain interactions and residual stresses. A micromechanically motivated continuum damage model is established to simulate degradation processes. The goal of the simulation tools is to predict the different constitutive behaviors, ME coupling properties and lifetime of smart magnetoelectric devices.

  20. Emotional noun processing: an ERP study with rapid serial visual presentation.

    Directory of Open Access Journals (Sweden)

    Shengnan Yi

    Full Text Available Reading is an important part of our daily life, and rapid responses to emotional words have received a great deal of research interest. Our study employed rapid serial visual presentation to detect the time course of emotional noun processing using event-related potentials. We performed a dual-task experiment, where subjects were required to judge whether a given number was odd or even, and the category into which each emotional noun fit. In terms of P1, we found that there was no negativity bias for emotional nouns. However, emotional nouns elicited larger amplitudes in the N170 component in the left hemisphere than did neutral nouns. This finding indicated that in later processing stages, emotional words can be discriminated from neutral words. Furthermore, positive, negative, and neutral words were different from each other in the late positive complex, indicating that in the third stage, even different emotions can be discerned. Thus, our results indicate that in a three-stage model the latter two stages are more stable and universal.

  1. Emotional noun processing: an ERP study with rapid serial visual presentation.

    Science.gov (United States)

    Yi, Shengnan; He, Weiqi; Zhan, Lei; Qi, Zhengyang; Zhu, Chuanlin; Luo, Wenbo; Li, Hong

    2015-01-01

    Reading is an important part of our daily life, and rapid responses to emotional words have received a great deal of research interest. Our study employed rapid serial visual presentation to detect the time course of emotional noun processing using event-related potentials. We performed a dual-task experiment, where subjects were required to judge whether a given number was odd or even, and the category into which each emotional noun fit. In terms of P1, we found that there was no negativity bias for emotional nouns. However, emotional nouns elicited larger amplitudes in the N170 component in the left hemisphere than did neutral nouns. This finding indicated that in later processing stages, emotional words can be discriminated from neutral words. Furthermore, positive, negative, and neutral words were different from each other in the late positive complex, indicating that in the third stage, even different emotions can be discerned. Thus, our results indicate that in a three-stage model the latter two stages are more stable and universal.

  2. Presenting a comprehensive market oriented model and evaluating its impact on organization performance

    Directory of Open Access Journals (Sweden)

    Mohammad Taqi Amini

    2013-08-01

    Full Text Available Like other innovative strategies, companies have paid more attention to market oriented strategies in recent years. This has been focused by organizations for improved effectiveness and the organization performance accelerated a lot in business competition. In responding to this fact, organizations are trying to formulate many of the issues familiar to large organizations, which have involved with market oriented strategy planning. This paper reviews key elements in market-oriented strategy planning with regard to competitiveness and performance in large organizations and outlines a comprehensive model for strategy planning in profit organizations. These elements include environment, top management, organization structure and market oriented strategy. Professional question of this study has a particularly important role in formulating relations of this model. These elements are well positioned to evaluate the impact of market-oriented strategy planning on organizations and their expected impacts on organization performance. A well-organized questionnaire to help organizations with their planning is proposed in this survey. Based on the proposed questionnaire, data obtained from Tehran food industry experts and analyzed by using SEM method. Results accepted eight hypotheses and rejected one.

  3. Towards artificial tissue models: past, present, and future of 3D bioprinting.

    Science.gov (United States)

    Arslan-Yildiz, Ahu; El Assal, Rami; Chen, Pu; Guven, Sinan; Inci, Fatih; Demirci, Utkan

    2016-03-01

    Regenerative medicine and tissue engineering have seen unprecedented growth in the past decade, driving the field of artificial tissue models towards a revolution in future medicine. Major progress has been achieved through the development of innovative biomanufacturing strategies to pattern and assemble cells and extracellular matrix (ECM) in three-dimensions (3D) to create functional tissue constructs. Bioprinting has emerged as a promising 3D biomanufacturing technology, enabling precise control over spatial and temporal distribution of cells and ECM. Bioprinting technology can be used to engineer artificial tissues and organs by producing scaffolds with controlled spatial heterogeneity of physical properties, cellular composition, and ECM organization. This innovative approach is increasingly utilized in biomedicine, and has potential to create artificial functional constructs for drug screening and toxicology research, as well as tissue and organ transplantation. Herein, we review the recent advances in bioprinting technologies and discuss current markets, approaches, and biomedical applications. We also present current challenges and provide future directions for bioprinting research.

  4. Past and present variability of the solar-terrestrial system: measurement, data analysis and theoretical models

    Energy Technology Data Exchange (ETDEWEB)

    Cini Castagnoli, G.; Provenzale, A. [eds.

    1997-12-31

    The course Past and present variability of the solar-terrestrial system: measurement, data analysis and theoretical models is explicitly devoted to these issues. A solar cycle ago, in summer 1985, G. Cini organized a similar school, in a time when this field was in a very early stage of development and definitely fewer high-quality measurements were available. After eleven years, the field has grown toward becoming a robust scientific discipline, new data have been obtained, and new ideas have been proposed by both solar physicists and climate dynamicists. For this reason, the authors felt that it was the right time to organize a new summer school, with the aim of formalizing the developments that have taken place during these years, and also for speculating and maybe dreaming of new results that will be achieved in the upcoming years. The papers of the lectures have now been collected in this volume. First, in order to know what the authors talking about, they need to obtain reliable data from terrestrial archives,and to properly date the records that have been measured. To these crucial aspects is devoted the first part of the book, dealing with various types of proxy data and with the difficult issue of the dating of the records.

  5. [Proposed difficult airway teaching methodology. Presentation of an interactive fresh frozen cadaver model].

    Science.gov (United States)

    Catalá Bauset, J C; de Andres Ibañez, J A; Valverde Navarro, A; Martinez Soriano, F

    2014-04-01

    The aim of this paper is to present a methodology based on the use of fresh-frozen cadavers for training in the management of the airway, and to evaluate the degree of satisfaction among learning physicians. About 6 fresh-frozen cadavers and 14 workstations were prepared where participants were trained in the different skills needed for airway management. The details of preparation of the cadavers are described. The level of satisfaction of the participant was determined using a Likert rating scale of 5 points, at each of the 14 stations, as well as the overall assessment and clinical usefulness of the course. The mean overall evaluation of the course and its usefulness was 4.75 and 4.9, out of 5, respectively. All parts of the course were rated above 4 out of 5. The high level of satisfaction of the course remained homogeneous in the 2 editions analysed. The overall satisfaction of the course was not finally and uniquely determined by any of its particular parts. The fresh cadaver model for training physicians in techniques of airway management is a proposal satisfactory to the participant, and with a realism that approaches the live patient. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

  6. Presentation, calibration and validation of the low-order, DCESS Earth System Model (Version 1

    Directory of Open Access Journals (Sweden)

    J. O. Pepke Pedersen

    2008-11-01

    remineralization rates in the litter and soil are related to mean atmospheric temperatures. Methane production is a small fraction of the soil remineralization. The lithosphere module considers outgassing, weathering of carbonate and silicate rocks and weathering of rocks containing old organic carbon and phosphorus. Weathering rates are related to mean atmospheric temperatures.

    A pre-industrial, steady state calibration to Earth system data is carried out. Ocean observations of temperature, carbon 14, phosphate, dissolved oxygen, dissolved inorganic carbon and alkalinity constrain air-sea exchange and ocean circulation, mixing and biogeochemical parameters. Observed calcite and organic carbon distributions and inventories in the ocean sediment help constrain sediment module parameters. Carbon isotopic data and carbonate vs. silicate weathering fractions are used to estimate initial lithosphere outgassing and rock weathering rates. Model performance is tested by simulating atmospheric greenhouse gas increases, global warming and model tracer evolution for the period 1765 to 2000, as forced by prescribed anthropogenic greenhouse gas inputs and other anthropogenic and natural forcing. Long term, transient model behavior is studied with a set of 100 000 year simulations, forced by a slow, 5000 Gt C input of CO2 to the atmosphere, and with a 1.5 million year simulation, forced by a doubling of lithosphere CO2 outgassing.

  7. Webinar Presentation: Epidemiologic Studies of the Effects of Toxic Exposures on Brain and Behavior: Neuropsychological Assessment

    Science.gov (United States)

    This presentation, Epidemiologic Studies of the Effects of Toxic Exposures on Brain and Behavior: Neuropsychological Assessment, was given at the NIEHS/EPA Children's Centers 2015 Webinar Series: Interdisciplinary Approaches to Neurodevelopment.

  8. [Environment and health in Gela (Sicily): present knowledge and prospects for future studies].

    Science.gov (United States)

    Musmeci, Loredana; Bianchi, Fabrizio; Carere, Mario; Cori, Liliana

    2009-01-01

    40-km range. Infact, the overall mortality rate for tumor and non-tumor causes in Gela is significantly higher for both sexes, and this is shown also in the Municipality of Niscemi, especially among the male population. Hospital discharge records for tumor causes, but especially for non-tumor ones, exceeded expectations in both genders and must be analysed taking into consideration the attraction exerted on the surrounding areas by the Gela hospital. Data analysis according to 5 ten-year birth cohorts, from 1915 to 1964, shows a decreasing mortality trend, whereas the increase of hospital admissions is confirmed in the younger generations. The issue of birth defects is recurrent in this area: a suitable register is lacking so that updated figures cannot be presented. However, data previously published showed excesses of prevalence rates of several specific birth defects, mainly urinary tract and genital anomalies. The same is worth in the incidence of new cancer cases since the development of a proper register is yet in progress. Tools and methodologies that should be applied in Gela to study environment-health relations are proposed, like Life Cycle Analysis, dispersion patterns and an air-quality monitoring system. A conceptual model considering all pollution sources and different exposure patterns present in Gela, developed by the Multidisciplinary Working Group, is presented. Among the activities carried out by regional authorities, two Reports on the Regional Environment Protection Agency monitoring activity and on the EU Program SEARCH, School Environment And Respiratory Health in Children, are included. A section is devoted to understanding what is necessary to build an epidemiological monitoring system specifically designed for this area, in order to keep under permanent control environment-related health outcomes. This includes a systematic and continuative collection, storage and analysis of environmental-induced diseases, exposure and risk factors, as well

  9. Modeling extracellular matrix (ECM) alterations in ovarian cancer by multiphoton excited fabrication of stromal models (Conference Presentation)

    Science.gov (United States)

    Campagnola, Paul J.; Ajeti, Visar; Lara, Jorge; Eliceiri, Kevin W.; Patankar, Mansh

    2016-04-01

    A profound remodeling of the extracellular matrix (ECM) occurs in human ovarian cancer but it unknown how this affects tumor growth, where this understanding could lead to better diagnostics and therapeutic approaches. We investigate the role of these ECM alterations by using multiphoton excited (MPE) polymerization to fabricate biomimetic models to investigate operative cell-matrix interactions in invasion/metastasis. First, we create nano/microstructured gradients mimicking the basal lamina to study adhesion/migration dynamics of ovarian cancer cells of differing metastatic potential. We find a strong haptotactic response that depends on both contact guidance and ECM binding cues. While we found enhanced migration for more invasive cells, the specifics of alignment and directed migration also depend on cell polarity. We further use MPE fabrication to create collagen scaffolds with complex, 3D submicron morphology. The stromal scaffold designs are derived directly from "blueprints" based on SHG images of normal, high risk, and malignant ovarian tissues. The models are seeded with different cancer cell lines and this allows decoupling of the roles of cell characteristics (metastatic potential) and ECM structure and composition (normal vs cancer) on adhesion/migration dynamics. We found the malignant stroma structure promotes enhanced migration and proliferation and also cytoskeletal alignment. Creating synthetic models based on fibers patterns further allows decoupling the topographic roles of the fibers themselves vs their alignment within the tissue. These models cannot be synthesized by other conventional fabrication methods and we suggest the MPE image-based fabrication method will enable a variety of studies in cancer biology.

  10. Promoter or enhancer, what's the difference? Deconstruction of established distinctions and presentation of a unifying model

    DEFF Research Database (Denmark)

    Andersson, Robin

    2015-01-01

    Gene transcription is strictly controlled by the interplay of regulatory events at gene promoters and gene-distal regulatory elements called enhancers. Despite extensive studies of enhancers, we still have a very limited understanding of their mechanisms of action and their restricted spatio......-temporal activities. A better understanding would ultimately lead to fundamental insights into the control of gene transcription and the action of regulatory genetic variants involved in disease. Here, I review and discuss pros and cons of state-of-the-art genomics methods to localize and infer the activity...... of enhancers. Among the different approaches, profiling of enhancer RNAs yields the highest specificity and may be superior in detecting in vivo activity. I discuss their apparent similarities to promoters, which challenge the established view of enhancers and promoters as distinct entities, and present...

  11. Insight into runoff characteristics using hydrological modeling in the data-scarce southern Tibetan Plateau: Past, present, and future.

    Science.gov (United States)

    Cai, Mingyong; Yang, Shengtian; Zhao, Changsen; Zhou, Qiuwen; Hou, Lipeng

    2017-01-01

    Regional hydrological modeling in ungauged regions has attracted growing attention in water resources research. The southern Tibetan Plateau often suffers from data scarcity in watershed hydrological simulation and water resources assessment. This hinders further research characterizing the water cycle and solving international water resource issues in the area. In this study, a multi-spatial data based Distributed Time-Variant Gain Model (MS-DTVGM) is applied to the Yarlung Zangbo River basin, an important international river basin in the southern Tibetan Plateau with limited meteorological data. This model is driven purely by spatial data from multiple sources and is independent of traditional meteorological data. Based on the methods presented in this study, daily snow cover and potential evapotranspiration data in the Yarlung Zangbo River basin in 2050 are obtained. Future (2050) climatic data (precipitation and air temperature) from the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR5) are used to study the hydrological response to climate change. The result shows that river runoff will increase due to precipitation and air temperature changes by 2050. Few differences are found between daily runoff simulations from different Representative Concentration Pathway (RCP) scenarios (RCP2.6, RCP4.5 and RCP8.5) for 2050. Historical station observations (1960-2000) at Nuxia and model simulations for two periods (2006-2009 and 2050) are combined to study inter-annual and intra-annual runoff distribution and variability. The inter-annual runoff variation is stable and the coefficient of variation (CV) varies from 0.21 to 0.27. In contrast, the intra-annual runoff varies significantly with runoff in summer and autumn accounting for more than 80% of the total amount. Compared to the historical period (1960-2000), the present period (2006-2009) has a slightly uneven intra-annual runoff temporal distribution, and becomes more balanced in

  12. Insight into runoff characteristics using hydrological modeling in the data-scarce southern Tibetan Plateau: Past, present, and future.

    Directory of Open Access Journals (Sweden)

    Mingyong Cai

    Full Text Available Regional hydrological modeling in ungauged regions has attracted growing attention in water resources research. The southern Tibetan Plateau often suffers from data scarcity in watershed hydrological simulation and water resources assessment. This hinders further research characterizing the water cycle and solving international water resource issues in the area. In this study, a multi-spatial data based Distributed Time-Variant Gain Model (MS-DTVGM is applied to the Yarlung Zangbo River basin, an important international river basin in the southern Tibetan Plateau with limited meteorological data. This model is driven purely by spatial data from multiple sources and is independent of traditional meteorological data. Based on the methods presented in this study, daily snow cover and potential evapotranspiration data in the Yarlung Zangbo River basin in 2050 are obtained. Future (2050 climatic data (precipitation and air temperature from the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR5 are used to study the hydrological response to climate change. The result shows that river runoff will increase due to precipitation and air temperature changes by 2050. Few differences are found between daily runoff simulations from different Representative Concentration Pathway (RCP scenarios (RCP2.6, RCP4.5 and RCP8.5 for 2050. Historical station observations (1960-2000 at Nuxia and model simulations for two periods (2006-2009 and 2050 are combined to study inter-annual and intra-annual runoff distribution and variability. The inter-annual runoff variation is stable and the coefficient of variation (CV varies from 0.21 to 0.27. In contrast, the intra-annual runoff varies significantly with runoff in summer and autumn accounting for more than 80% of the total amount. Compared to the historical period (1960-2000, the present period (2006-2009 has a slightly uneven intra-annual runoff temporal distribution, and becomes more

  13. Past, present and prospect of an Artificial Intelligence (AI) based model for sediment transport prediction

    Science.gov (United States)

    Afan, Haitham Abdulmohsin; El-shafie, Ahmed; Mohtar, Wan Hanna Melini Wan; Yaseen, Zaher Mundher

    2016-10-01

    An accurate model for sediment prediction is a priority for all hydrological researchers. Many conventional methods have shown an inability to achieve an accurate prediction of suspended sediment. These methods are unable to understand the behaviour of sediment transport in rivers due to the complexity, noise, non-stationarity, and dynamism of the sediment pattern. In the past two decades, Artificial Intelligence (AI) and computational approaches have become a remarkable tool for developing an accurate model. These approaches are considered a powerful tool for solving any non-linear model, as they can deal easily with a large number of data and sophisticated models. This paper is a review of all AI approaches that have been applied in sediment modelling. The current research focuses on the development of AI application in sediment transport. In addition, the review identifies major challenges and opportunities for prospective research. Throughout the literature, complementary models superior to classical modelling.

  14. The Past, Present and Future of Cyber-Physical Systems: A Focus on Models

    Science.gov (United States)

    Lee, Edward A.

    2015-01-01

    This paper is about better engineering of cyber-physical systems (CPSs) through better models. Deterministic models have historically proven extremely useful and arguably form the kingpin of the industrial revolution and the digital and information technology revolutions. Key deterministic models that have proven successful include differential equations, synchronous digital logic and single-threaded imperative programs. Cyber-physical systems, however, combine these models in such a way that determinism is not preserved. Two projects show that deterministic CPS models with faithful physical realizations are possible and practical. The first project is PRET, which shows that the timing precision of synchronous digital logic can be practically made available at the software level of abstraction. The second project is Ptides (programming temporally-integrated distributed embedded systems), which shows that deterministic models for distributed cyber-physical systems have practical faithful realizations. These projects are existence proofs that deterministic CPS models are possible and practical. PMID:25730486

  15. The Past, Present and Future of Cyber-Physical Systems: A Focus on Models

    Directory of Open Access Journals (Sweden)

    Edward A. Lee

    2015-02-01

    Full Text Available This paper is about better engineering of cyber-physical systems (CPSs through better models. Deterministic models have historically proven extremely useful and arguably form the kingpin of the industrial revolution and the digital and information technology revolutions. Key deterministic models that have proven successful include differential equations, synchronous digital logic and single-threaded imperative programs. Cyber-physical systems, however, combine these models in such a way that determinism is not preserved. Two projects show that deterministic CPS models with faithful physical realizations are possible and practical. The first project is PRET, which shows that the timing precision of synchronous digital logic can be practically made available at the software level of abstraction. The second project is Ptides (programming temporally-integrated distributed embedded systems, which shows that deterministic models for distributed cyber-physical systems have practical faithful realizations. These projects are existence proofs that deterministic CPS models are possible and practical.

  16. The past, present and future of cyber-physical systems: a focus on models.

    Science.gov (United States)

    Lee, Edward A

    2015-02-26

    This paper is about better engineering of cyber-physical systems (CPSs) through better models. Deterministic models have historically proven extremely useful and arguably form the kingpin of the industrial revolution and the digital and information technology revolutions. Key deterministic models that have proven successful include differential equations, synchronous digital logic and single-threaded imperative programs. Cyber-physical systems, however, combine these models in such a way that determinism is not preserved. Two projects show that deterministic CPS models with faithful physical realizations are possible and practical. The first project is PRET, which shows that the timing precision of synchronous digital logic can be practically made available at the software level of abstraction. The second project is Ptides (programming temporally-integrated distributed embedded systems), which shows that deterministic models for distributed cyber-physical systems have practical faithful realizations. These projects are existence proofs that deterministic CPS models are possible and practical.

  17. STUDY OF CLINICAL PROFILE OF PATIENTS PRESENTING WITH SEXUAL PRECOCITY TO A TERTIARY CARE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Binoy Kumar Mohanty

    2016-07-01

    Full Text Available BACKGROUND Precocious puberty is a common paediatric endocrine disorder seen in clinical practice. OBJECTIVE To study the various aetiologies and clinical presentations of patients presenting with sexual precocity to a tertiary care hospital. DESIGN Cross sectional study. MATERIAL AND METHODS We collected and analysed the clinical data including hormonal status of 24 consecutive patients who presented to our department from January 2014 to December 2015 for evaluation of sexual precocity. RESULTS Most of the patients presenting to us had evidence of precocious puberty (n=16, followed by premature adrenarche (n=5 and premature thelarche (n=3 respectively. The females outnumbered males in our study (68.75% of total cases. Females presenting with central precocious puberty had no appreciable cause (idiopathic in majority (85.72% of cases. While, males presenting with central precocious puberty had an organic cause (60% in majority of cases. CONCLUSIONS Precocious puberty is more common among females as compared to males. Organic lesion must be ruled out in all patients presenting with central precocious puberty especially in males.

  18. A Study of the Effect of Color in Memory Retention When Used in Presentation Software.

    Science.gov (United States)

    McConnohie, Bruce Vernon

    A study of the effects of color as used in presentation software on short-range (immediately following treatment) and long-range (one hour following treatment) memory retention was conducted. Previous studies have concentrated on color as cueing or coding mechanisms primarily in print media and have not explored the effect of individual colors as…

  19. Thyroid Autoantibodies and the Clinical Presentation of Moyamoya Disease: A Prospective Study.

    Science.gov (United States)

    Lanterna, Luigi A; Galliani, Silvia; Zangari, Rosalia; Conti, Luciano; Brembilla, Carlo; Gritti, Paolo; Colleoni, Maria Luisa; Bernucci, Claudio

    2018-05-01

    Moyamoya is a rare cerebrovascular disease characterized by the progressive occlusion of the intracranial carotid artery. Thyroid autoantibodies have been found to be associated with the disease, but their clinical significance has never been studied. The objective of this study was to investigate the relationship between thyroid autoantibodies and the clinical presentation of moyamoya. This is a prospective study including 37 patients with moyamoya disease (MMD) or unilateral moyamoya (uMM). Thyroid function and thyroid autoantibodies (e.g., antithyroperoxidase and antithyroglobulin) were investigated. We studied the effect of gender, age, type of moyamoya (uMM versus MMD), and thyroid autoantibodies on the clinical presentation, dichotomized into aggressive (hemorrhage, major stroke, or frequent transient ischemic attack [TIA]) and nonaggressive presentation (headache, rare TIAs, and incidental diagnosis) according to the criteria of the Research Committee on Spontaneous Occlusion of the Circle of Willis. Of the 37 patients included in the study, the autoantibodies were elevated in 9 (24.3%). An aggressive presentation occurred in 21 patients (hemorrhage in 11, major stroke in 9, frequent TIAs in 1). The autoantibodies were elevated in 8 of the 21 patients (38.09%) with an aggressive presentation and in 1 of those presenting with minor symptoms (6.2%). The presence of elevated autoantibodies was the only variable associated with an aggressive presentation in the multivariate logistic analysis (P = .048). When the serum concentration of the thyroid autoantibodies is increased, the patients have a higher risk of an aggressive presentation. Our results support the hypothesis that activation of immune-mediated processes affects the moyamoya physiopathology. Copyright © 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  20. STUDY OF CLINICAL PRESENTATIONS OF PATIENTS WITH HYPERPROLACTINAEMIA VISITING A TERTIARY CARE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Binoy Kumar Mohanty

    2016-06-01

    Full Text Available BACKGROUND Hyperprolactinaemia is one of the common endocrine disorders seen in clinical practice. It may result due to various causes and elucidating the exact cause is necessary to formulate the right therapy. OBJECTIVE To study the various aetiologies and clinical presentation of patients presenting with hyperprolactinaemia to a tertiary care hospital. DESIGN Cross-sectional study. MATERIAL AND METHODS We collected and analysed the clinical data including hormonal status of 74 consecutive patients who presented to our department from June 2015 to May 2016 for evaluation of hyperprolactinaemia. RESULTS Majority of the subjects studied belonged to 20-29 years group (47.29% followed by 30-39 years age group (24.32%. The most common cause in our population was due to drug-induced causes (35.13%. The next common causes included idiopathic group (20.4% followed by pituitary adenomas (16.21%. There was significant female predominance (83.78% among total cases. Among women who presented with hyperprolactinaemia, menstrual irregularity (69.35% followed by galactorrhoea (35.48% were the most common presentations. CONCLUSIONS Hyperprolactinaemia is frequently seen among women who presented with either menstrual irregularity or galactorrhoea or both. Drug-induced hyperprolactinaemia is the most common cause seen in our study population.

  1. Rapid Prototyping — A Tool for Presenting 3-Dimensional Digital Models Produced by Terrestrial Laser Scanning

    Directory of Open Access Journals (Sweden)

    Juho-Pekka Virtanen

    2014-07-01

    Full Text Available Rapid prototyping has received considerable interest with the introduction of affordable rapid prototyping machines. These machines can be used to manufacture physical models from three-dimensional digital mesh models. In this paper, we compare the results obtained with a new, affordable, rapid prototyping machine, and a traditional professional machine. Two separate data sets are used for this, both of which were acquired using terrestrial laser scanning. Both of the machines were able to produce complex and highly detailed geometries in plastic material from models based on terrestrial laser scanning. The dimensional accuracies and detail levels of the machines were comparable, and the physical artifacts caused by the fused deposition modeling (FDM technique used in the rapid prototyping machines could be found in both models. The accuracy of terrestrial laser scanning exceeded the requirements for manufacturing physical models of large statues and building segments at a 1:40 scale.

  2. Fluorescence lifetime imaging of endogenous molecules in live mouse cancer models (Conference Presentation)

    Science.gov (United States)

    Svindrych, Zdenek; Wang, Tianxiong; Hu, Song; Periasamy, Ammasi

    2017-02-01

    NADH and FAD are important endogenous fluorescent coenzymes participating in key enzymatic reactions of cellular metabolism. While fluorescence intensities of NADH and FAD have been used to determine the redox state of cells and tissues, this simple approach breaks down in the case of deep-tissue intravital imaging due to depth- and wavelength-dependent light absorption and scattering. To circumvent this limitation, our research focuses on fluorescence lifetimes of two-photon excited NADH and FAD emission to study the metabolic state of live tissues. In our custom-built scanning microscope we combine tunable femtosecond Ti:sapphire laser (operating at 740 nm for NADH excitation and 890 nm for FAD excitation), two GaAsP hybrid detectors for registering individual fluorescence photons and two Becker and Hickl time correlator boards for high precision lifetime measurements. Together with our rigorous FLIM analysis approach (including image segmentation, multi-exponential decay fitting and detailed statistical analysis) we are able to detect metabolic changes in cancer xenografts (human pancreatic cancer MPanc96 cells injected subcutaneously into the ear of an immunodeficient nude mouse), relative to surrounding healthy tissue. Advantageously, with the same instrumentation we can also take high-resolution and high-contrast images of second harmonic signal (SHG) originating from collagen fibers of both the healthy skin and the growing tumor. The combination of metabolic measurements (NADH and FAD lifetime) and morphological information (collagen SHG) allows us to follow the tumor growth in live mouse model and the changes in tumor microenvironment.

  3. Nuclear clustering - a cluster core model study

    International Nuclear Information System (INIS)

    Paul Selvi, G.; Nandhini, N.; Balasubramaniam, M.

    2015-01-01

    Nuclear clustering, similar to other clustering phenomenon in nature is a much warranted study, since it would help us in understanding the nature of binding of the nucleons inside the nucleus, closed shell behaviour when the system is highly deformed, dynamics and structure at extremes. Several models account for the clustering phenomenon of nuclei. We present in this work, a cluster core model study of nuclear clustering in light mass nuclei

  4. APPLICATION OF AUGMENTED AND VIRTUAL REALITY IN RESIDENTIAL COMPLEX PRESENTATION, CASE STUDY: ENERGOPROJEKT SUNNYVILLE

    Directory of Open Access Journals (Sweden)

    PEJIC Petar

    2017-05-01

    Full Text Available The traditional method of residential complex project presentations involves the use of a printed poster or elaborate on which the building is presented by using of two-dimensional drawings and images. The main traditional approach problem is the presentation of three-dimensional space on two-dimensional paper. The main focus of this paper is the development of contemporary, mobile systems for residential complex presentations which will be presented on a case study of “Energoprojekt Sunnyville” using a method of virtual and augmented reality. This approach enables easier and better understanding of all types of architectural objects and urban complex, allowing the user intuitive spatial overview of architectural work.

  5. Carcinogenic risk for workers exposed to ionizing radiation. A critical review of present epidemiologic studies

    International Nuclear Information System (INIS)

    Tirmarche, M.

    1987-01-01

    Epidemiologic studies on workers who have been exposed to ionizing radiation have allowed to demonstrate certain cancer risks associated with elevated, often retrospectively reconstituted exposures. Present studies on still active workers or workers having worked for the last 15 years are indispensable to define the risk associated with low irradiation doses; they must, however, take into account confounding factors that may play a role in the etiology of the cancer studied

  6. Prospective study of POLG mutations presenting in children with intractable epilepsy: Prevalence and clinical features

    OpenAIRE

    Uusimaa, Johanna; Gowda, Vasantha; McShane, Anthony; Smith, Conrad; Evans, Julie; Shrier, Annie; Narasimhan, Manisha; O'Rourke, Anthony; Rajabally, Yusuf; Hedderly, Tammy; Cowan, Frances; Fratter, Carl; Poulton, Joanna

    2013-01-01

    Purpose To assess the frequency and clinical features of childhood-onset intractable epilepsy caused by the most common mutations in the POLG gene, which encodes the catalytic subunit of mitochondrial DNA polymerase gamma. Methods Children presenting with nonsyndromic intractable epilepsy of unknown etiology but without documented liver dysfunction at presentation were eligible for this prospective, population-based study. Blood samples were analyzed for the three most common POLG mutations. ...

  7. The FODA-TDMA satellite access scheme - Presentation, study of the system, and results

    Science.gov (United States)

    Celandroni, Nedo; Ferro, Erina

    1991-12-01

    A description is given of FODA-TDMA, a satellite access scheme designed for mixed traffic. The study of the system is presented and the choice of some parameters is justified. A simplified analytic solution is found, describing the steady-state behavior of the system. Some results of the simulation tests for an already existing hardware environment are also presented for the channel speeds of 2 and 8 Mb/s, considering both the stationary and the transient cases. The results of the experimentation at 2 Mb/s on the satellite Eutelsat-F2 are also presented and compared with the results of the simulation.

  8. Product modeling standards for the building and construction industry : Past, present and future

    NARCIS (Netherlands)

    Tolman, F.P.

    1999-01-01

    For the past ten years most sectors of industry have been developing standards for the electronic sharing and exchange of product model data. While several related industries, such as automotive and shipbuilding manufacturing have been relatively successful in integrating electronic product models

  9. Presentation of a stochastic model estimating the wind energy contribution in remote island electrical networks

    International Nuclear Information System (INIS)

    Kaldellis, J.K.; Kapsali, M.; Tiligadas, D.

    2012-01-01

    Highlights: ► This study estimates the maximum wind energy contribution to an isolated micro-grid. ► An integrated computational tool is developed on the basis of stochastic analysis. ► The probability distribution of the wind energy surplus and deficit is estimated. ► The results indicate that a strict penetration limit is imposed to wind energy. -- Abstract: The electrification in remote islands whose electricity distribution network is not connected to the mainland’s grid is mostly based on Autonomous Power Stations (APSs) that are usually characterized by a considerably high electricity production cost, while at the same time the contribution of Renewable Energy Sources (RES) in these regions accounts for less than 10% of the total electricity generation. This actually results from the fact that despite the excellent wind potential of most of these islands, the wind energy contribution is significantly restricted from limits imposed to protect the remote electrical grids from possible instability problems, due to the stochastic wind speed behavior and the variable electricity consumption. On the basis of probability distribution of the load demand of a representative Greek island and the corresponding data related to the available wind potential, the present study estimates the maximum – acceptable by the local grid – wind energy contribution. For that reason, an integrated computational algorithm has been developed from first principles, based on a stochastic analysis. According to the results obtained, it becomes evident that with the current wind turbine technology, wind energy cannot play a key role in coping with the electrification problems encountered in many Greek island regions, excluding however the case of introducing bulk energy storage systems that may provide considerable recovery of the remarkable wind energy rejections expected.

  10. Model quality and safety studies

    DEFF Research Database (Denmark)

    Petersen, K.E.

    1997-01-01

    The paper describes the EC initiative on model quality assessment and emphasizes some of the problems encountered in the selection of data from field tests used in the evaluation process. Further, it discusses the impact of model uncertainties in safety studies of industrial plants. The model...... that most of these have never been through a procedure of evaluation, but nonetheless are used to assist in making decisions that may directly affect the safety of the public and the environment. As a major funder of European research on major industrial hazards, DGXII is conscious of the importance......-tain model is appropriate for use in solving a given problem. Further, the findings from the REDIPHEM project related to dense gas dispersion will be highlighted. Finally, the paper will discuss the need for model quality assessment in safety studies....

  11. Insect symbioses: a case study of past, present, and future fungus-growing ant research

    DEFF Research Database (Denmark)

    Caldera, Eric J; Poulsen, Michael; Suen, Garret

    2009-01-01

    's fungus garden, antibiotic-producing actinobacteria that help protect the fungus garden from the parasite, and a black yeast that parasitizes the ant-actinobacteria mutualism. The fungus-growing ant symbiosis serves as a particularly useful model system for studying insect-microbe symbioses, because...

  12. Presentation Technique

    International Nuclear Information System (INIS)

    Froejmark, M.

    1992-10-01

    The report presents a wide, easily understandable description of presentation technique and man-machine communication. General fundamentals for the man-machine interface are illustrated, and the factors that affect the interface are described. A model is presented for describing the operators work situation, based on three different levels in the operators behaviour. The operator reacts routinely in the face of simple, known problems, and reacts in accordance with predetermined plans in the face of more complex, recognizable problems. Deep fundamental knowledge is necessary for truly complex questions. Today's technical status and future development have been studied. In the future, the operator interface will be based on standard software. Functions such as zooming, integration of video pictures, and sound reproduction will become common. Video walls may be expected to come into use in situations in which several persons simultaneously need access to the same information. A summary of the fundamental rules for the design of good picture ergonomics and design requirements for control rooms are included in the report. In conclusion, the report describes a presentation technique within the Distribution Automation and Demand Side Management area and analyses the know-how requirements within Vattenfall. If different systems are integrated, such as geographical information systems and operation monitoring systems, strict demands are made on the expertise of the users for achieving a user-friendly technique which is matched to the needs of the human being. (3 figs.)

  13. An eye movement study for identification of suitable font characters for presentation on a computer screen.

    Science.gov (United States)

    Banerjee, Jayeeta; Majumdar, Dhurjati; Majumdar, Deepti; Pal, Madhu Sudan

    2010-06-01

    We are experiencing a shifting of media: from the printed paper to the computer screen. This transition is modifying the process of how we read and understand a text. It is very difficult to conclude on suitability of font characters based upon subjective evaluation method only. Present study evaluates the effect of font type on human cognitive workload during perception of individual alphabets on a computer screen. Twenty six young subjects volunteered for this study. Here, subjects have been shown individual characters of different font types and their eye movements have been recorded. A binocular eye movement recorder was used for eye movement recording. The results showed that different eye movement parameters such as pupil diameter, number of fixations, fixation duration were less for font type Verdana. The present study recommends the use of font type Verdana for presentation of individual alphabets on various electronic displays in order to reduce cognitive workload.

  14. Full text publication rates of studies presented at an international emergency medicine scientific meeting.

    Science.gov (United States)

    Chan, Jannet W M; Graham, Colin A

    2011-09-01

    The publication rate of full text papers following an abstract presentation at a medical conference is variable, and few studies have examined the situation with respect to international emergency medicine conferences. This retrospective study aimed to identify the publication rate of abstracts presented at the 2006 International Conference on Emergency Medicine (ICEM) held in Halifax, Canada. The full text publication rate was 33.2%, similar to previous emergency medicine meetings. English language barriers may play a role in the low publication rate seen.

  15. A RETROSPECTIVE STUDY ON CLINICAL PRESENTATION OF STEROID SENSITIVE NEPHROTIC SYNDROME

    Directory of Open Access Journals (Sweden)

    Sosamma M. M

    2016-09-01

    Full Text Available BACKGROUND Nephrotic syndrome is a disease affecting the renal system. Most paediatricians will invariably encounter children with nephrotic syndrome in their clinic. The disease is characterised by the presence of oedema, persistent heavy proteinuria, hypoproteinaemia and hypercholesterolaemia. The disease is influenced by factors like age, geography, race and also has certain genetic influence related to HLA (DR7, B12, B8. In children, minimal change nephrotic syndrome is the most common variant of primary nephrotic syndrome. It accounts to more than eighty per cent of the cases seen children under seven years whereas it has a chance of fifty per cent in the age group of seven to sixteen years. Males are affected two times higher compared to females. The parents usually bring the child to the hospital with signs of oedema. Usually, the child recovers with treatment, but in some cases, there can be relapse. MATERIALS AND METHODS  The study was conducted in the Department of Paediatrics, Travancore Medical College, Kollam.  The study was done from January 2015 to January 2016.  Sixty cases were identified and were chosen for the study. INCLUSION CRITERIA 1. Steroid sensitive cases of nephrotic syndrome. 2. Age less than twelve years. 3. Admitted cases. EXCLUSION CRITERIA 1. Steroid-resistant and steroid-dependent cases. 2. Age more than twelve years. 3. Outpatient cases. RESULTS Out of the sixty cases studied, forty one cases belonged to male sex and nineteen cases belonged to female sex. Based on the age group, maximum number of cases belonged to age group four to eight years, which amounted to thirty four cases followed by age group eight to twelve years, which amounted to eighteen cases. Age group zero to four years had the least number of cases, which amounted to eight in number. Based on clinical signs and symptoms, fifty five cases presented with oedema either periorbital, scrotal or pedal oedema. Ten cases presented with fever

  16. Management of breech presentation at term: a retrospective cohort study of 10 years of experience.

    Science.gov (United States)

    Burgos, J; Rodríguez, L; Cobos, P; Osuna, C; Del Mar Centeno, M; Larrieta, R; Martínez-Astorquiza, T; Fernández-Llebrez, L

    2015-10-01

    To evaluate the impact of management of childbirth (external cephalic version (ECV) plus planned vaginal delivery (PVD)) of breech presentation at term (⩾37 weeks of gestation). This retrospective cohort study was based on data collected of singleton breech presentations at term in the Obstetrics and Gynaecology Service, Cruces University Hospital (Biscay, Spain), from January 2003 to December 2012. We attended 2377 singleton breech pregnancies at term. We attended 1684 singleton breech term deliveries, attempting vaginal delivery after selection in 52.9% of cases and were successful in 57.5% of attempts. A total of 1360 ECV were attempted, with a success rate of 50.3% of those attempted. The use of ECV has decreased the rate of breech presentation at delivery by 39.0%, the rate of breech presentation as a caesarean section (CS) indication by 47.1% (CS due to breech presentation/total of CS) and the rate of CS for breech presentation out of the total of deliveries by 39.1% (CS due to breech presentation/total of deliveries). Early postnatal parameters (5-min Apgar score, umbilical cord arterial pH and acid-base analysis) were significantly lower following PVD compared with planned CS for breech presentation. However, we did not find any differences in the rates of admissions to the neonatal unit or neonatal mortality. Management of breech presentation with a protocol that includes ECV, careful selection criteria and active management of vaginal delivery achieve a great decrease in the rate of CS for breech presentation.

  17. Using Integrated Environmental Modeling to Automate a Process-Based Quantitative Microbial Risk Assessment (presentation)

    Science.gov (United States)

    Integrated Environmental Modeling (IEM) organizes multidisciplinary knowledge that explains and predicts environmental-system response to stressors. A Quantitative Microbial Risk Assessment (QMRA) is an approach integrating a range of disparate data (fate/transport, exposure, and...

  18. Environmental Models as a Service: Enabling Interoperability through RESTful Endpoints and API Documentation (presentation)

    Science.gov (United States)

    Achieving interoperability in environmental modeling has evolved as software technology has progressed. The recent rise of cloud computing and proliferation of web services initiated a new stage for creating interoperable systems. Scientific programmers increasingly take advantag...

  19. Developing Charismatic Delivery through Transformational Presentations: Modeling the Persona of Steve Jobs

    Science.gov (United States)

    Ivic, Rebecca K.; Green, Robert J.

    2012-01-01

    How can public speaking instructors teach students how to be charismatic and confident speakers? The activity presented in this article suggests that instructors foster competent and charismatic presentational skills by having students channel the stylistic capabilities of an exceptional speaker. The activity requires students to take on the…

  20. Prospective validation of a predictive model that identifies homeless people at risk of re-presentation to the emergency department.

    Science.gov (United States)

    Moore, Gaye; Hepworth, Graham; Weiland, Tracey; Manias, Elizabeth; Gerdtz, Marie Frances; Kelaher, Margaret; Dunt, David

    2012-02-01

    To prospectively evaluate the accuracy of a predictive model to identify homeless people at risk of representation to an emergency department. A prospective cohort analysis utilised one month of data from a Principal Referral Hospital in Melbourne, Australia. All visits involving people classified as homeless were included, excluding those who died. Homelessness was defined as living on the streets, in crisis accommodation, in boarding houses or residing in unstable housing. Rates of re-presentation, defined as the total number of visits to the same emergency department within 28 days of discharge from hospital, were measured. Performance of the risk screening tool was assessed by calculating sensitivity, specificity, positive and negative predictive values and likelihood ratios. Over the study period (April 1, 2009 to April 30, 2009), 3298 presentations from 2888 individuals were recorded. The homeless population accounted for 10% (n=327) of all visits and 7% (n=211) of all patients. A total of 90 (43%) homeless people re-presented to the emergency department. The predictive model included nine variables and achieved 98% (CI, 0.92-0.99) sensitivity and 66% (CI, 0.57-0.74) specificity. The positive predictive value was 68% and the negative predictive value was 98%. The positive likelihood ratio 2.9 (CI, 2.2-3.7) and the negative likelihood ratio was 0.03 (CI, 0.01-0.13). The high emergency department re-presentation rate for people who were homeless identifies unresolved psychosocial health needs. The emergency department remains a vital access point for homeless people, particularly after hours. The risk screening tool is key to identify medical and social aspects of a homeless patient's presentation to assist early identification and referral. Copyright © 2012 College of Emergency Nursing Australasia Ltd. Published by Elsevier Ltd. All rights reserved.

  1. Initial experience with a group presentation of study results to research participants

    Directory of Open Access Journals (Sweden)

    Bent Stephen

    2008-03-01

    Full Text Available Abstract Background Despite ethical imperatives, informing research participants about the results of the studies in which they take part is not often performed. This is due, in part, to the costs and burdens of communicating with each participant after publication of the results. Methods Following the closeout and publication of a randomized clinical trial of saw palmetto for treatment of symptoms of benign prostatic hyperplasia, patients were invited back to the research center to participate in a group presentation of the study results. Results Approximately 10% of participants attended one of two presentation sessions. Reaction to the experience of the group presentation was very positive among the attendees. Conclusion A group presentation to research participants is an efficient method of communicating study results to those who desire to be informed and was highly valued by those who attended. Prospectively planning for such presentations and greater scheduling flexibility may result in higher attendance rates. Trial Registration Number Clinicaltrials.gov #NCT00037154

  2. Nuclear Structure Studies On Exotic Nuclei With Radioactive Beams - Present Status And Future Perspectives At FAIR

    International Nuclear Information System (INIS)

    Peter Egelhof

    2011-01-01

    The investigation of nuclear reactions using radioactive beams in inverse kinematics gives access to a wide field of nuclear structure studies in the region far off stability. The basic concept and the methods involved are briefly discussed, and an overview including some selected examples of recent results obtained with radioactive beams from the present fragment separator at GSI Darmstadt is presented. The experimental conditions expected at the future international facility FAIR will, among others, allow for a substantial improvement in intensity and quality of radioactive beams as compared to present facilities. Therefore, it is expected that FAIR will provide unique opportunities for nuclear structure studies on nuclei far off stability, and will allow to explore new regions in the chart of nuclides of high interest for nuclear structure and nuclear astrophysics. A brief overview on the new facility, and on the experimental setups planned for nuclear structure research with radioactive beams is given. For nuclear reaction studies several complex, highly efficient, high resolution, and universal detection systems such as R 3 B, EXL, ELISe, etc. are presently under design and construction. A brief overview on the research objectives and the technical realization will be presented. (author)

  3. Modeling soluble salt assemblages on Mars: past aqueous history and present-day habitability

    Science.gov (United States)

    Toner, J. D.; Catling, D. C.; Light, B.

    2014-12-01

    Soluble salt assemblages formed through aqueous processes are widespread on Mars. These minerals are important for understanding the past aqueous history of Mars and indicate critical habitability parameters such as pH, temperature, water activity, and salinity. Equilibrium models have been used to determine solution chemistry and salt precipitation sequences from aqueous chemical data; however, current models are limited by a lack of experimental data for low-temperature perchlorates, and some model predictions are clearly anomalous. To address the need for accurate equilibrium models, we have developed a comprehensive model for low-temperature perchlorate-rich brines using (1) previously neglected literature data, (2) experimental solubilities determined in low-temperature perchlorate solutions, and (3) solubility and heat capacity results determined using Differential Scanning Calorimetry (DSC). Our resulting model is a significant improvement over existing models, such as FREZCHEM, particularly for perchlorate mixtures. We have applied our model to evaporation and freezing of a nominal Wet Chemistry Laboratory (WCL) solution measured at the Phoenix site. For a freezing WCL solution, our model indicates that ice, KClO4, hydromagnesite (3MgCO3·Mg(OH)2·3H2O), calcite (CaCO3), meridianiite (MgSO4·11H2O), MgCl2·12H2O, NaClO4·2H2O, and Mg(ClO4)2·6H2O form at the eutectic (209 K); whereas, KClO4, hydromagnesite, kieserite (MgSO4·H2O), anhydrite (CaSO4), halite (NaCl), NaClO4·H2O, and Mg(ClO4)2·6H2O form upon complete evaporation at 298 K. In general, evaporation yields more dehydrated mineral assemblages than salts produced by freezing. Hydrated phases that form during evaporation contain 0.3 wt. % water, which compares with 1.2 wt. % during freezing. Given independent evidence for the presence of calcite and minimum water contents in Martian soils of ~1.5 wt. %, salts at the Phoenix site, and possibly elsewhere, appear more likely to have formed during

  4. The last interglacial in the Mediterranean as a model for the present interglacial

    Science.gov (United States)

    Zaso, C.; Goy, J. L.; Dabrio, C. J.; Bardaji, T.; Somoza, L.; Silva, P. G.

    1993-05-01

    Deposits of the Last Interglacial on the south and southeastern coasts of Spain are shallow marine and coastal sediments, with a warm fauna of Strombus bubonius. These units exhibit a diversity of morpho-sedimentary models controlled by the tectonic activity of the Mediterranean area, which is closely related to the approximation of Africa and Iberia during the Quaternary. There are three well-dated peaks of maximum sea level (T-I: isotopic substage 7a, T-II: isotopic substage 5e, T-III: isotopic substage 5c). A younger episode, T-IV, probably corresponds to the isotopic substage 5a. Episodes T-II, T-III and T-IV were laid down during Last Interglacial age. In addition, three Holocene peaks of maximum sea level: H 1 ca. 5100 yr B.P., H 2 ca. 3500 yr B.P. and H 3 ca. 2400 yr B.P. were found. The three main peaks of the Last Interglacial correspond to the morpho-sedimentary Tyrrhenian units T-II, T-III and T-IV, deposited during a time span of some 45,000 years. Several smaller oscillations can be distinguished within each of these units as subunits separated by erosional surfaces. At least three of such mapable subunits were distinguished within the peak T-II (5e); each lasted ca. 10,500 yr. As the positive oscillations of sea level (H 1, H 2, and H 3) recorded during the present Interglacial (Holocene) are much shorter, we infer that they are smaller-scale fluctuations (2500-1100 yr cycles) within the first oscillation (duration: ca. 10,500 yr) of the first Holocene peak of sea level which has not yet been completed. In addition to changes of sea level, the vertical and lateral arrangement of morpho-sedimentary units, which can be designated as the stratigraphic architecture, depends on tectonics and oceanography, including geoidal and steric changes and coastal dynamics. The coastal dynamics factor largely depends on the exchange of waters between the Atlantic and the Mediterranean. Maximum incursions of water coincides with warm periods (highstands) when the

  5. A STUDY ON PATTERN OF SKIN DISEASES AMONG CHILDREN PRESENTING TO RIMS, KADAPA, A. P.

    OpenAIRE

    Vamseedhar; Masroor Ahamed; Vijaya Kumar; Rama Mohan

    2015-01-01

    BACKGROUND: Little information is available about the prevalence of skin conditions among children in the general population in India. Low socioeconomic status, malnutrition, overcrowding and poor standards of hygiene are important factors accounting for the distribut ion of skin diseases in developing countries such as India. AIM OF THE STUDY: To study prevalence of skin diseases among children presenting to paediatric OPD. METERIALS AND METHODS: A predesigned ...

  6. A Study on the Learning Efficiency of Multimedia-Presented, Computer-Based Science Information

    Science.gov (United States)

    Guan, Ying-Hua

    2009-01-01

    This study investigated the effects of multimedia presentations on the efficiency of learning scientific information (i.e. information on basic anatomy of human brains and their functions, the definition of cognitive psychology, and the structure of human memory). Experiment 1 investigated whether the modality effect could be observed when the…

  7. A psychology literature study on modality related issues for multimodal presentation in crisis management

    NARCIS (Netherlands)

    Cao, Y.

    2008-01-01

    The motivation of this psychology literature study is to obtain modality related guidelines for real-time information presentation in crisis management environment. The crisis management task is usually companied by time urgency, risk, uncertainty, and high information density. Decision makers

  8. Local Music Collections: Strategies for Digital Access, Presentation, and Preservation--A Case Study

    Science.gov (United States)

    Doi, Carolyn

    2015-01-01

    The Saskatchewan Music Collection (SMC) is a local music collection held at the University of Saskatchewan. This case study examines a project to digitize and present this unique special collection in the online environment. The project aims to facilitate access to the collection, preserve the collection and promote scholarship and interest in the…

  9. Estimation of otitis media in ancient populations: A study of past and present Greenlandic Inuit

    DEFF Research Database (Denmark)

    Homøe, P; Lynnerup, N; Skovgaard, Lene Theil

    1996-01-01

    Examination of disease patterns in the past has often been difficult due to lack of morphological evidence. This study presents a new unbiased method for estimation of occurrence of infectious middle ear disease (IMED) in childhood. The method is based on the relation between IMED in childhood an...

  10. Curriculum Studies in Brazil: Intellectual Histories, Present Circumstances. International and Development Education

    Science.gov (United States)

    Pinar, William F., Ed.

    2011-01-01

    This collection, comprised of chapters focused on the intellectual histories and present circumstances of curriculum studies in Brazil, is Pinar's summary of exchanges (occurring over a two-year period) between the authors and members of an International Panel (scholars working in Finland, South Africa, the United States). From these and the…

  11. Nuclear magnetic resonance. Present results and its application to renal pathology. Experimental study of hydronephrosis

    International Nuclear Information System (INIS)

    Bertrand, P.

    1987-01-01

    Results of proton nuclear magnetic resonance imaging and relaxation time measurement of experimental hydronephrosis in mice are presented. The study is preceded by a description of the physical principles underlying the phenomenon of nuclear magnetic resonance and of its biomedical applications and with a review of the clinical use of NMR imaging in renal pathology [fr

  12. Presentation of the health impact evaluation study of atmospheric emissions of a major coal combustion installation

    International Nuclear Information System (INIS)

    Bonnard, R.

    2004-12-01

    In the framework of a working group on the major installations, a study has been realized on a today coal combustion installation. The direct risk by inhalation and the risks bond to indirect exposure of atmospheric releases were analyzed. The calculation method is explained and the uncertainties are discussed to present the results. (A.L.B.)

  13. A STUDY ON VARIOUS MODES OF PRESENTATION OF GASTROINTESTINAL TUBERCULOSIS AT EMERGENCY, ITS MANAGEMENT AND OUTCOMES

    Directory of Open Access Journals (Sweden)

    Krishna Mohan

    2016-02-01

    Full Text Available Abdominal tuberculosis is the 6th most common form of extrapulmonary tuberculosis, among which ileocaecal tuberculosis is most common. Tuberculosis has been declared a global emergency by the World Health Organization (WHO and is the most important communicable disease worldwide. Approximately one third of the world population is infected and about three millions die each year from this disease. It presents with a wide variety of symptoms and signs. Gastrointestinal tuberculosis presents to emergency department as subacute intestinal obstruction, acute intestinal obstruction and peritonitis. Although Antitubercular chemotherapy is the mainstay in treatment of abdominal tuberculosis, surgical intervention becomes necessary for two reasons- diagnostic and therapeutic. Diagnostic laparotomy becomes necessary for histopathological/microbiological diagnosis, more often in patients with peritoneal or lymph node TB. Therapeutic surgery is the treatment of choice in emergency for treating intestinal obstruction & peritonitis. Morbidity and mortality will be high in patients with late presentation and associated comorbidities. AIMS AND OBJECTIVES: (1 To study various modes of presentation and management of Gastrointestinal Tuberculosis at emergency surgical care, in our hospital, its management and outcomes. (2 To evaluate the morbidity and mortality in acute presentations of Gastrointestinal tuberculosis. MATERIALS AND METHODS An Observational study of 40 patients admitted in the acute surgical care unit of Our Hospital, Hyderabad, presenting with acute abdomen who have been confirmed to have Gastrointestinal tuberculosis at laparotomy and on histopathology from Aug 2013 to Aug 2015. The patient was managed by laparotomy and procedure according to the mode of presentation. All the patients were given ATT post operatively. RESULTS Gastrointestinal tuberculosis is more common in 2nd and 3rd decade of life. Acute presentations were found to be more common

  14. A Case Study Application Of Time Study Model In Paint ...

    African Journals Online (AJOL)

    This paper presents a case study in the development and application of a time study model in a paint manufacturing company. The organization specializes in the production of different grades of paint and paint containers. The paint production activities include; weighing of raw materials, drying of raw materials, dissolving ...

  15. A mixed model framework for teratology studies.

    Science.gov (United States)

    Braeken, Johan; Tuerlinckx, Francis

    2009-10-01

    A mixed model framework is presented to model the characteristic multivariate binary anomaly data as provided in some teratology studies. The key features of the model are the incorporation of covariate effects, a flexible random effects distribution by means of a finite mixture, and the application of copula functions to better account for the relation structure of the anomalies. The framework is motivated by data of the Boston Anticonvulsant Teratogenesis study and offers an integrated approach to investigate substantive questions, concerning general and anomaly-specific exposure effects of covariates, interrelations between anomalies, and objective diagnostic measurement.

  16. Comparison of models of automatic classification of textural patterns of mineral presents in Colombian coals

    International Nuclear Information System (INIS)

    Lopez Carvajal, Jaime; Branch Bedoya, John Willian

    2005-01-01

    The automatic classification of objects is a very interesting approach under several problem domains. This paper outlines some results obtained under different classification models to categorize textural patterns of minerals using real digital images. The data set used was characterized by a small size and noise presence. The implemented models were the Bayesian classifier, Neural Network (2-5-1), support vector machine, decision tree and 3-nearest neighbors. The results after applying crossed validation show that the Bayesian model (84%) proved better predictive capacity than the others, mainly due to its noise robustness behavior. The neuronal network (68%) and the SVM (67%) gave promising results, because they could be improved increasing the data amount used, while the decision tree (55%) and K-NN (54%) did not seem to be adequate for this problem, because of their sensibility to noise

  17. Knowledge modelling and reliability processing: presentation of the Figaro language and associated tools

    International Nuclear Information System (INIS)

    Bouissou, M.; Villatte, N.; Bouhadana, H.; Bannelier, M.

    1991-12-01

    EDF has been developing for several years an integrated set of knowledge-based and algorithmic tools for automation of reliability assessment of complex (especially sequential) systems. In this environment, the reliability expert has at his disposal all the powerful software tools for qualitative and quantitative processing, besides he gets various means to generate automatically the inputs for these tools, through the acquisition of graphical data. The development of these tools has been based on FIGARO, a specific language, which was built to get an homogeneous system modelling. Various compilers and interpreters get a FIGARO model into conventional models, such as fault-trees, Markov chains, Petri Networks. In this report, we introduce the main basics of FIGARO language, illustrating them with examples

  18. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 2: Papers and presentations

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, R.L.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process -- and how -- would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies, or exercises. The conference proceedings consist of three volumes. Volume 1 contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and panels. This volume contains a short introduction and the papers and presentations from the conference. Volume 3 contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.). Individual papers in this volume were abstracted and indexed for the database.

  19. Modeling the present and future impact of aviation on climate: an AOGCM approach with online coupled chemistry

    Directory of Open Access Journals (Sweden)

    P. Huszar

    2013-10-01

    Full Text Available Our work is among the first that use an atmosphere-ocean general circulation model (AOGCM with online chemistry to evaluate the impact of future aviation emissions on temperature. Other particularities of our study include non-scaling to the aviation emissions, and the analysis of models' transient response using ensemble simulations. The model we use is the Météo-France CNRM-CM5.1 earth system model extended with the REPROBUS chemistry scheme. The time horizon of our interest is 1940–2100, assuming the A1B SRES scenario. We investigate the present and future impact of aviation emissions of CO2, NOx and H2O on climate, taking into account changes in greenhouse gases, contrails and contrail-induced cirrus (CIC. As in many transport-related impact studies, we distinguish between the climate impacts of CO2 emissions and those of non-CO2 emissions. Aviation-produced aerosol is not considered in the study. Our modeling system simulated a notable sea-ice bias in the Arctic, and therefore results concerning the surface should be viewed with caution. The global averaged near-surface CO2 impact reaches around 0.1 K by the end of the 21st century, while the non-CO2 impact reaches 0.2 K in the second half of the century. The NOx emissions impact is almost negligible in our simulations, as our aviation-induced ozone production is small. As a consequence, the non-CO2 signal is very similar to the CIC signal. The seasonal analysis shows that the strongest warming due to aviation is modeled for the late summer and early autumn. In the stratosphere, a significant cooling is attributed to aviation CO2 emissions (−0.25 K by 2100. A −0.3 K temperature decrease is modeled when considering all the aviation emissions, but no significant signal appears from the CIC or NOx forcings in the stratosphere.

  20. Monte Carlo modelling of the Belgian materials testing reactor BR2: present status

    International Nuclear Information System (INIS)

    Verboomen, B.; Aoust, Th.; Raedt, Ch. de; Beeckmans de West-Meerbeeck, A.

    2001-01-01

    A very detailed 3-D MCNP-4B model of the BR2 reactor was developed to perform all neutron and gamma calculations needed for the design of new experimental irradiation rigs. The Monte Carlo model of BR2 includes the nearly exact geometrical representation of fuel elements (now with their axially varying burn-up), of partially inserted control and regulating rods, of experimental devices and of radioisotope production rigs. The multiple level-geometry possibilities of MCNP-4B are fully exploited to obtain sufficiently flexible tools to cope with the very changing core loading. (orig.)

  1. Presentation, calibration and validation of the low-order, DCESS Earth System Model

    DEFF Research Database (Denmark)

    Shaffer, G.; Olsen, S. Malskaer; Pedersen, Jens Olaf Pepke

    2008-01-01

    A new, low-order Earth system model is described, calibrated and tested against Earth system data. The model features modules for the atmosphere, ocean, ocean sediment, land biosphere and lithosphere and has been designed to simulate global change on time scales of years to millions of years...... remineralization. The lithosphere module considers outgassing, weathering of carbonate and silicate rocks and weathering of rocks containing old organic carbon and phosphorus. Weathering rates are related to mean atmospheric temperatures. A pre-industrial, steady state calibration to Earth system data is carried...

  2. Beyond the CRAB symptoms: a study of presenting clinical manifestations of multiple myeloma.

    Science.gov (United States)

    Talamo, Giampaolo; Farooq, Umar; Zangari, Maurizio; Liao, Jason; Dolloff, Nathan G; Loughran, Thomas P; Epner, Elliot

    2010-12-01

    Although the typical clinical manifestations of multiple myeloma (MM) are summarized by the CRAB symptoms (hypercalcemia, renal insufficiency, anemia, and bone lesions), a significant proportion of patients with MM present with a variety of other clinical manifestations. We conducted a study evaluating the presenting symptoms that led to the diagnosis of MM. We conducted a retrospective review of 170 consecutive patients with MM seen at the Penn State Hershey Cancer Institute. Among patients with symptomatic MM, 74% presented with CRAB symptoms, 20% presented with non-CRAB manifestations, and 6% had both clinical features. Ten categories of non-CRAB manifestations were found, in order of decreasing frequency: neuropathy (because of spinal cord compression, nerve root compression, or peripheral neuropathy), extramedullary involvement, hyperviscosity syndrome, concomitant amyloidosis (eg, nephrotic syndrome or cardiopathy), hemorrhage/coagulopathy, systemic symptoms (eg, fever or weight loss), primary plasma cell leukemia, infections, cryoglobulinemia, and secondary gout. Kaplan-Meier estimates of survival in patients with non-CRAB manifestations did not show a significant difference from the survival of patients presenting with CRAB symptoms. Presenting symptoms of MM may be grouped in a total of 14 categories, 4 for the CRAB and 10 for the less common non-CRAB features. Grouped together, non-CRAB manifestations do not appear to confer a negative effect on the prognosis of patients with MM.

  3. The present status of the study on the validity of concurrent verbalization

    International Nuclear Information System (INIS)

    Watanabe, Megumi; Takahashi, Hideaki.

    1993-09-01

    We reviewed study on the validity of the method of verbal reports. The method of verbal reports gives us detailed information about human cognitive process as compared with observing a sequence of actions, while it is subjected to criticism for the validity as data. Ericsson and Simon proposed a model of verbalization and investigated conditions to keep verbal reports valid. Although a lot of studies quote their model as a base of adopting the method of verbal reports, verification the validity of verbal reports is incomplete because effects of verbalization is not clear. We pointed out that it is necessary to take into consideration kinds of task strategies, effects of trial repetition, effects of task difficulty to examine precisely effects of verbalization. (author)

  4. Status of barium studies in the present era of oncology: Are they a history?

    Science.gov (United States)

    Mahajan, Abhishek; Desai, Subash; Sable, Nilesh Pandurang; Thakur, Meenakshi Haresh

    2016-01-01

    With the advent of the modern imaging technologies, the present era of oncology is seeing steady decline in requests for barium studies due to the many reasons. It is prudent to mention here, that, barium examinations cannot be made obsolete! Our aim to preserve the age old technique of barium studies not only to keep it going on but also for the betterment and appropriate management of the patient. Our goal is not to "save" barium studies simply to keep this technology alive, per se, but rather to preserve barium radiology for the quality in patient care.

  5. Working Group 1: Software System Design and Implementation for Environmental Modeling (presentation)

    Science.gov (United States)

    Background: Nine Federal agencies have been cooperating under a Memorandum of Understanding (MOU) on the research and development of multimedia environmental models. The MOU, which was revised in 2012, continues an effort that began in 2001. It establishes a framework for facilit...

  6. Solar PV Manufacturing Cost Model Group: Installed Solar PV System Prices (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Goodrich, A. C.; Woodhouse, M.; James, T.

    2011-02-01

    EERE's Solar Energy Technologies Program is charged with leading the Secretary's SunShot Initiative to reduce the cost of electricity from solar by 75% to be cost competitive with conventional energy sources without subsidy by the end of the decade. As part of this Initiative, the program has funded the National Renewable Energy Laboratory (NREL) to develop module manufacturing and solar PV system installation cost models to ensure that the program's cost reduction targets are carefully aligned with current and near term industry costs. The NREL cost analysis team has leveraged the laboratories' extensive experience in the areas of project finance and deployment, as well as industry partnerships, to develop cost models that mirror the project cost analysis tools used by project managers at leading U.S. installers. The cost models are constructed through a "bottoms-up" assessment of each major cost element, beginning with the system's bill of materials, labor requirements (type and hours) by component, site-specific charges, and soft costs. In addition to the relevant engineering, procurement, and construction costs, the models also consider all relevant costs to an installer, including labor burdens and overhead rates, supply chain costs, and overhead and materials inventory costs, and assume market-specific profits.

  7. Present State of the Single and Twin Aperture Short Dipole Model Program for the LHC

    CERN Document Server

    Andreyev, N I; Kurtyka, T; Leroy, D; Oberli, L R; Perini, D; Russenschuck, Stephan; Siegel, N; Siemko, A; Tommasini, D; Vanenkov, I; Walckiers, L; Weterings, W

    1998-01-01

    The LHC model program for main dipoles is based on the design, fabrication and testing at CERN of a number of single and twin aperture 1m long magnets. So far, a number of single aperture models, each with specific characteristics, were tested at 2 K at a rate of about one per month. These magnets are the main tool used to check coil performance as a function of design and assembly options in view of optimizing and finalizing choices of components and procedures. Initial quenching field levels of 8.8 T were obtained and the short sample limit of the cable at 1.9 K was reached corresponding to a central bore field of 10 T. A few twin aperture dipole models were also built and tested, using the same structural components as for the long magnets which are now being built in industry. The paper discusses the main characteristics of the models built so far, the instrumentation developed to date and the experience obtained. Finally it describes the plans aimed at continuing a vigorous program to provide input to th...

  8. First-order fire effects on herbs and Shrubs: present knowledge and process modeling needs

    Science.gov (United States)

    Kirsten Stephan; Melanie Miller; Matthew B. Dickinson

    2010-01-01

    Herbaceous plants and shrubs have received little attention in terms of fire effects modeling despite their critical role in ecosystem integrity and resilience after wildfires and prescribed burns. In this paper, we summarize current knowledge of direct effects of fire on herb and shrub (including cacti) vegetative tissues and seed banks, propose key components for...

  9. Lecture Presentations

    International Nuclear Information System (INIS)

    2007-01-01

    The Heavy-Ion Collisions in the LHC workshop held in Cracow from 18 to 18 May 2007. The main subject of the workshop was to present the newest results of research provided at CERN LHC collider. Additionally some theoretical models and methods used for presented data analysis were discussed

  10. Presenting a new kinetic model for methanol to light olefins reactions over a hierarchical SAPO-34 catalyst using the Langmuir-Hinshelwood-Hougen-Watson mechanism

    Science.gov (United States)

    Javad Azarhoosh, Mohammad; Halladj, Rouein; Askari, Sima

    2017-10-01

    In this study, a new kinetic model for methanol to light olefins (MTO) reactions over a hierarchical SAPO-34 catalyst using the Langmuir-Hinshelwood-Hougen-Watson (LHHW) mechanism was presented and the kinetic parameters was obtained using a genetic algorithm (GA) and genetic programming (GP). Several kinetic models for the MTO reactions have been presented. However, due to the complexity of the reactions, most reactions are considered lumped and elementary, which cannot be deemed a completely accurate kinetic model of the process. Therefore, in this study, the LHHW mechanism is presented as kinetic models of MTO reactions. Because of the non-linearity of the kinetic models and existence of many local optimal points, evolutionary algorithms (GA and GP) are used in this study to estimate the kinetic parameters in the rate equations. Via the simultaneous connection of the code related to modelling the reactor and the GA and GP codes in the MATLAB R2013a software, optimization of the kinetic models parameters was performed such that the least difference between the results from the kinetic models and experiential results was obtained and the best kinetic parameters of MTO process reactions were achieved. A comparison of the results from the model with experiential results showed that the present model possesses good accuracy.

  11. Tackling causes and costs of ED presentation for American football injuries: a population-level study.

    Science.gov (United States)

    Smart, Blair J; Haring, R Sterling; Asemota, Anthony O; Scott, John W; Canner, Joseph K; Nejim, Besma J; George, Benjamin P; Alsulaim, Hatim; Kirsch, Thomas D; Schneider, Eric B

    2016-07-01

    American tackle football is the most popular high-energy impact sport in the United States, with approximately 9 million participants competing annually. Previous epidemiologic studies of football-related injuries have generally focused on specific geographic areas or pediatric age groups. Our study sought to examine patient characteristics and outcomes, including hospital charges, among athletes presenting for emergency department (ED) treatment of football-related injury across all age groups in a large nationally representative data set. Patients presenting for ED treatment of injuries sustained playing American tackle football (identified using International Classification of Diseases, Ninth Revision, Clinical Modification code E007.0) from 2010 to 2011 were studied in the Nationwide Emergency Department Sample. Patient-specific injuries were identified using the primary International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code and categorized by type and anatomical region. Standard descriptive methods examined patient demographics, diagnosis categories, and ED and inpatient outcomes and charges. During the study period 397363 football players presented for ED treatment, 95.8% of whom were male. Sprains/strains (25.6%), limb fractures (20.7%), and head injuries (including traumatic brain injury; 17.5%) represented the most presenting injuries. Overall, 97.9% of patients underwent routine ED discharge with 1.1% admitted directly and fewer than 11 patients in the 2-year study period dying prior to discharge. The proportion of admitted patients who required surgical interventions was 15.7%, of which 89.9% were orthopedic, 4.7% neurologic, and 2.6% abdominal. Among individuals admitted to inpatient care, mean hospital length of stay was 2.4days (95% confidence interval, 2.2-2.6) and 95.6% underwent routine discharge home. The mean total charge for all patients was $1941 (95% confidence interval, $1890-$1992) with substantial

  12. Present and future ecological niche modeling of garter snake species from the Trans-Mexican Volcanic Belt

    Science.gov (United States)

    García-Vázquez, Uri; D’Addario, Maristella

    2018-01-01

    Land use and climate change are affecting the abundance and distribution of species. The Trans-Mexican Volcanic Belt (TMVB) is a very diverse region due to geological history, geographic position, and climate. It is also one of the most disturbed regions in Mexico. Reptiles are particularly sensitive to environmental changes due to their low dispersal capacity and thermal ecology. In this study, we define the important environmental variables (considering climate, topography, and land use) and potential distribution (present and future) of the five Thamnophis species present in TMVB. To do so, we used the maximum entropy modeling software (MAXENT). First, we modeled to select the most important variables to explain the distribution of each species, then we modeled again using only the most important variables and projected these models to the future considering a middle-moderate climate change scenario (rcp45), and land use and vegetation variables for the year 2050 (generated according to land use changes that occurred between years 2002 and 2011). Arid vegetation had an important negative effect on habitat suitability for all species, and minimum temperature of the coldest month was important for four of the five species. Thamnophis cyrtopsis was the species with the lowest tolerance to minimum temperatures. The maximum temperature of the warmest month was important for T. scalaris and T. cyrtopsis. Low percentages of agriculture were positive for T. eques and T. melanogaster but, at higher values, agriculture had a negative effect on habitat suitability for both species. Elevation was the most important variable to explain T. eques and T. melanogaster potential distribution while distance to Abies forests was the most important variable for T. scalaris and T. scaliger. All species had a high proportion of their potential distribution in the TMVB. However, according to our models, all Thamnophis species will experience reductions in their potential

  13. An ergonomics study of computerized emergency operating procedures: Presentation style, task complexity, and training level

    International Nuclear Information System (INIS)

    Xu Song; Song Fei; Li Zhizhong; Zhao Qianyi; Luo Wei; He Xuhong; Salvendy, Gavriel

    2008-01-01

    Emergency operating procedures (EOPs) are widely used in nuclear power plants (NPPs). With the development of information technology, computerized EOPs are taking the place of paper-based ones. Unlike paper-based EOPs, the industrial practice of computerized EOPs is still quite limited. Ergonomics issues of computerized EOPs have not been studied adequately. This study focuses on the effects of EOP presentation style, task complexity, and training level on the performance of the operators in the execution of computerized EOPs. One simulated computerized EOP system was developed to present two EOPs, each with different task complexity levels, by two presentation styles (Style A: one- and two-dimensional flowcharts combination; Style B: two-dimensional flowchart and success logic tree combination). Forty subjects participated in the experiment of EOP execution using the simulated system. Statistical analysis of the experimental results indicates that: (1) complexity, presentation style, and training level all can significantly influence the error rate. High-complexity tasks and lack of sufficient training may lead to a higher error rate. Style B caused a significantly higher error rate than style A did in the skilled phase. So the designers of computerized procedures should take the presentation styles of EOPs into account. (2) Task complexity and training level can significantly influence operation time. No significant difference was found in operation time between the two presentation styles. (3) Training level can also significantly influence the subjective workload of EOPs operations. This implies that adequate training is very important for the performance of computerized EOPs even if emergency responses with computerized EOPs are much more simple and easy than that with paper-based EOPs

  14. An ergonomics study of computerized emergency operating procedures: Presentation style, task complexity, and training level

    Energy Technology Data Exchange (ETDEWEB)

    Xu Song; Song Fei [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China); Li Zhizhong [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China)], E-mail: zzli@tsinghua.edu.cn; Zhao Qianyi; Luo Wei [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China); He Xuhong [Scanpower Risk Management China Inc., Towercrest International Plaza, No. 3 Maizidian West Road, Chaoyang District, Beijing 100016 (China); Salvendy, Gavriel [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China)

    2008-10-15

    Emergency operating procedures (EOPs) are widely used in nuclear power plants (NPPs). With the development of information technology, computerized EOPs are taking the place of paper-based ones. Unlike paper-based EOPs, the industrial practice of computerized EOPs is still quite limited. Ergonomics issues of computerized EOPs have not been studied adequately. This study focuses on the effects of EOP presentation style, task complexity, and training level on the performance of the operators in the execution of computerized EOPs. One simulated computerized EOP system was developed to present two EOPs, each with different task complexity levels, by two presentation styles (Style A: one- and two-dimensional flowcharts combination; Style B: two-dimensional flowchart and success logic tree combination). Forty subjects participated in the experiment of EOP execution using the simulated system. Statistical analysis of the experimental results indicates that: (1) complexity, presentation style, and training level all can significantly influence the error rate. High-complexity tasks and lack of sufficient training may lead to a higher error rate. Style B caused a significantly higher error rate than style A did in the skilled phase. So the designers of computerized procedures should take the presentation styles of EOPs into account. (2) Task complexity and training level can significantly influence operation time. No significant difference was found in operation time between the two presentation styles. (3) Training level can also significantly influence the subjective workload of EOPs operations. This implies that adequate training is very important for the performance of computerized EOPs even if emergency responses with computerized EOPs are much more simple and easy than that with paper-based EOPs.

  15. Present capabilities and new developments in antenna modeling with the numerical electromagnetics code NEC

    Energy Technology Data Exchange (ETDEWEB)

    Burke, G.J.

    1988-04-08

    Computer modeling of antennas, since its start in the late 1960's, has become a powerful and widely used tool for antenna design. Computer codes have been developed based on the Method-of-Moments, Geometrical Theory of Diffraction, or integration of Maxwell's equations. Of such tools, the Numerical Electromagnetics Code-Method of Moments (NEC) has become one of the most widely used codes for modeling resonant sized antennas. There are several reasons for this including the systematic updating and extension of its capabilities, extensive user-oriented documentation and accessibility of its developers for user assistance. The result is that there are estimated to be several hundred users of various versions of NEC world wide. 23 refs., 10 figs.

  16. Past, present and future of the pathophysiological model of the basal ganglia

    Directory of Open Access Journals (Sweden)

    Jose A Obeso

    2011-07-01

    Full Text Available The current model of basal ganglia was introduced two decades ago and has settled most of our current understanding of basal ganglia function and dysfunction. Extensive research efforts have been carried out in recent years leading to further refinement and understanding of the normal and diseased basal ganglia. Several questions, however, are yet to be resolved. This short review provides a synopsis of the evolution of thought regarding the pathophysiological model of the BG and summarizes the main recent findings and additions to this field of research. We have also tried to identify major challenges that need to be addressed and resolved in the near future. Detailed accounts and state-of-the-art developments concerning research on the basal ganglia are provided in the articles that make up this Special Issue.

  17. Modelling the many-body dynamics of heavy ion collisions. Present status and future perspective

    International Nuclear Information System (INIS)

    Hartnack, Ch.; Puri, R.K.; Aichelin, J.; Konopka, J.; Bass, S.A.; Stoecker, H.; Greiner, W.

    1996-01-01

    Basic problems of the semiclassical microscopic modelling of strongly interacting systems are discussed within the framework of Quantum Molecular Dynamics (QMD). It is shown that the same predictions can be obtained with several - numerically completely different and independently written -programs as far as the same model parameters are employed and the same basic approximations are made. Some of the physical results, however, depend also on rather technical parameters like the preparation of the initial configuration in phase space. This crucial problem is connected with the description of the ground state of single nuclei, which differs among the various approaches. An outlook to an improved molecular dynamics scheme for heavy ion collisions is given. (author)

  18. Modelling the many-body dynamics of heavy ion collisions. Present status and future perspective

    Energy Technology Data Exchange (ETDEWEB)

    Hartnack, Ch.; Puri, R.K.; Aichelin, J. [Centre National de la Recherche Scientifique, 44 - Nantes (France). Lab. de Physique Subatomique et des Technologies Associees; Konopka, J.; Bass, S.A.; Stoecker, H.; Greiner, W. [Johann Wolfgang Goethe Univ., Frankfurt am Main (Germany). Inst. fuer Theoretische Physik

    1996-12-31

    Basic problems of the semiclassical microscopic modelling of strongly interacting systems are discussed within the framework of Quantum Molecular Dynamics (QMD). It is shown that the same predictions can be obtained with several - numerically completely different and independently written -programs as far as the same model parameters are employed and the same basic approximations are made. Some of the physical results, however, depend also on rather technical parameters like the preparation of the initial configuration in phase space. This crucial problem is connected with the description of the ground state of single nuclei, which differs among the various approaches. An outlook to an improved molecular dynamics scheme for heavy ion collisions is given. (author). 86 refs.

  19. The present and future of the most favoured inflationary models after Planck 2015

    Energy Technology Data Exchange (ETDEWEB)

    Escudero, Miguel; Ramírez, Héctor; Boubekeur, Lotfi; Mena, Olga [Instituto de Física Corpuscular (IFIC), CSIC-Universitat de Valencia, Apartado de Correos 22085, E-46071 (Spain); Giusarma, Elena, E-mail: miguel.escudero@ific.uv.es, E-mail: hector.ramirez@ific.uv.es, E-mail: lboubekeur@usfq.edu.ec, E-mail: elena.giusarma@roma1.infn.it, E-mail: olga.mena@ific.uv.es [Physics Department and INFN, Università di Roma ' La Sapienza' , Piazzale Aldo Moro 2, 00185, Rome (Italy)

    2016-02-01

    The value of the tensor-to-scalar ratio r in the region allowed by the latest Planck 2015 measurements can be associated to a large variety of inflationary models. We discuss here the potential of future Cosmic Microwave Background cosmological observations in disentangling among the possible theoretical scenarios allowed by our analyses of current Planck temperature and polarization data. Rather than focusing only on r, we focus as well on the running of the primordial power spectrum, α{sub s} and the running thereof, β{sub s}. If future cosmological measurements, as those from the COrE mission, confirm the current best-fit value for β{sub s} ∼> 10{sup −2} as the preferred one, it will be possible to rule-out the most favoured inflationary models.

  20. Improving the reliability of seasonal climate forecasts through empirical downscaling and multi-model considerations; presentation

    CSIR Research Space (South Africa)

    Landman, WA

    2012-11-01

    Full Text Available , discrimination and sharpness. We present seasonal prediction verification for the equatorial Pacific Ocean (where El Niño and La Niña events occur) sea-surface temperatures. The verification is done over a recent multi-decadal period for which hindcasts (re...

  1. 2018 Military Retirement Options: An Expected Net Present Value Decision Analysis Model

    Science.gov (United States)

    2017-03-23

    and the Operational Research Commons This Thesis is brought to you for free and open access by AFIT Scholar. It has been accepted for inclusion in...and build a representation of the model using Microsoft Excel 2016, Visual Basics for Applications ( VBA ), and Excel’s Data Analysis Toolkit. The...stream of future income. However, these DOD TSP contributions are not readily accessible to the member until they reach age 59.5 due to IRS

  2. FDTD based model of ISOCT imaging for validation of nanoscale sensitivity (Conference Presentation)

    Science.gov (United States)

    Eid, Aya; Zhang, Di; Yi, Ji; Backman, Vadim

    2017-02-01

    Many of the earliest structural changes associated with neoplasia occur on the micro and nanometer scale, and thus appear histologically normal. Our group has established Inverse Spectroscopic OCT (ISOCT), a spectral based technique to extract nanoscale sensitive metrics derived from the OCT signal. Thus, there is a need to model light transport through relatively large volumes (< 50 um^3) of media with nanoscale level resolution. Finite Difference Time Domain (FDTD) is an iterative approach which directly solves Maxwell's equations to robustly estimate the electric and magnetic fields propagating through a sample. The sample's refractive index for every spatial voxel and wavelength are specified upon a grid with voxel sizes on the order of λ/20, making it an ideal modelling technique for nanoscale structure analysis. Here, we utilize the FDTD technique to validate the nanoscale sensing ability of ISOCT. The use of FDTD for OCT modelling requires three components: calculating the source beam as it propagates through the optical system, computing the sample's scattered field using FDTD, and finally propagating the scattered field back through the optical system. The principles of Fourier optics are employed to focus this interference field through a 4f optical system and onto the detector. Three-dimensional numerical samples are generated from a given refractive index correlation function with known parameters, and subsequent OCT images and mass density correlation function metrics are computed. We show that while the resolvability of the OCT image remains diffraction limited, spectral analysis allows nanoscale sensitive metrics to be extracted.

  3. Breast cancer patients' presentation for oncological treatment: a single centre study.

    Science.gov (United States)

    Akinkuolie, Akinbolaji Andrew; Etonyeaku, Amarachukwu Chiduziem; Olasehinde, Olalekan; Arowolo, Olukayode Adeolu; Babalola, Rereloluwa Nicodemus

    2016-01-01

    Breast cancer patients are presenting at advanced stages for oncological treatment in Nigeria and World Health Organization predicted developing countries' breast cancer incidence and mortality to increase by year 2020. Prospective observational hospital based study that enrolled breast cancer patients from catchment area of an oncology service hospital in Nigeria between 2007 and 2013. Patients' demographics, breast cancer burden and health care giver presentation variables were analysed for causal factors of seeking medical help and what determines commencement of effective oncological treatment. Forty-six patients were enrolled, 19.6% of them presented primarily to oncologist while 80.4% presented secondarily for oncological treatment. There is a significant difference in presentation time for oncological treatment (t = -3.56, df = 42.90, p = 0.001) between primary (M =11.56 ± 5.21 weeks) and secondary presentation (M= 52.56 ± 10.27weeks). Tumor burden of those that presented secondarily were significantly more advanced (U = 78.5, p = 0.011) and, univariate analysis reveals that: patients' matrimonial setting, breast cancer awareness and mode of discovery of breast symptoms are patient related factors that determines their choice of health care providers and, determinant of effective oncological treatment is patient first contact health care provider. Patients' bio-characteristics that determine their choice of health care provider should be incorporated into community breast cancer sensitization drives. Additionally, there is a need for a government agency assign the task of accrediting and defining scope of enterprise of health care institutions and their health care providers in our pluralist health system.

  4. Breast cancer patients’ presentation for oncological treatment: a single centre study

    Science.gov (United States)

    Akinkuolie, Akinbolaji Andrew; Etonyeaku, Amarachukwu Chiduziem; Olasehinde, Olalekan; Arowolo, Olukayode Adeolu; Babalola, Rereloluwa Nicodemus

    2016-01-01

    Introduction Breast cancer patients are presenting at advanced stages for oncological treatment in Nigeria and World Health Organization predicted developing countries’ breast cancer incidence and mortality to increase by year 2020. Methods Prospective observational hospital based study that enrolled breast cancer patients from catchment area of an oncology service hospital in Nigeria between 2007 and 2013. Patients’ demographics, breast cancer burden and health care giver presentation variables were analysed for causal factors of seeking medical help and what determines commencement of effective oncological treatment. Results Forty-six patients were enrolled, 19.6% of them presented primarily to oncologist while 80.4% presented secondarily for oncological treatment. There is a significant difference in presentation time for oncological treatment (t = -3.56, df = 42.90, p = 0.001) between primary (M =11.56 ± 5.21 weeks) and secondary presentation (M= 52.56 ± 10.27weeks). Tumor burden of those that presented secondarily were significantly more advanced (U = 78.5, p = 0.011) and, univariate analysis reveals that: patients’ matrimonial setting, breast cancer awareness and mode of discovery of breast symptoms are patient related factors that determines their choice of health care providers and, determinant of effective oncological treatment is patient first contact health care provider. Conclusion Patients’ bio-characteristics that determine their choice of health care provider should be incorporated into community breast cancer sensitization drives. Additionally, there is a need for a government agency assign the task of accrediting and defining scope of enterprise of health care institutions and their health care providers in our pluralist health system. PMID:27642404

  5. Present mantle flow in North China Craton constrained by seismic anisotropy and numerical modelling

    Science.gov (United States)

    Qu, W.; Guo, Z.; Zhang, H.; Chen, Y. J.

    2017-12-01

    North China Carton (NCC) has undergone complicated geodynamic processes during the Cenozoic, including the westward subduction of the Pacific plate to its east and the collision of the India-Eurasia plates to its southwest. Shear wave splitting measurements in NCC reveal distinct seismic anisotropy patterns at different tectonic blocks, that is, the predominantly NW-SE trending alignment of fast directions in the western NCC and eastern NCC, weak anisotropy within the Ordos block, and N-S fast polarization beneath the Trans-North China Orogen (TNCO). To better understand the origin of seismic anisotropy from SKS splitting in NCC, we obtain a high-resolution dynamic model that absorbs multi-geophysical observations and state-of-the-art numerical methods. We calculate the mantle flow using a most updated version of software ASPECT (Kronbichler et al., 2012) with high-resolution temperature and density structures from a recent 3-D thermal-chemical model by Guo et al. (2016). The thermal-chemical model is obtained by multi-observable probabilistic inversion using high-quality surface wave measurements, potential fields, topography, and surface heat flow (Guo et al., 2016). The viscosity is then estimated by combining the dislocation creep, diffusion creep, and plasticity, which is depended on temperature, pressure, and chemical composition. Then we calculate the seismic anisotropy from the shear deformation of mantle flow by DREX, and predict the fast direction and delay time of SKS splitting. We find that when complex boundary conditions are applied, including the far field effects of the deep subduction of Pacific plate and eastward escaping of Tibetan Plateau, our model can successfully predict the observed shear wave splitting patterns. Our model indicates that seismic anisotropy revealed by SKS is primarily resulting from the LPO of olivine due to the shear deformation from asthenospheric flow. We suggest that two branches of mantle flow may contribute to the

  6. A study of social information control affordances and gender difference in Facebook self-presentation.

    Science.gov (United States)

    Kuo, Feng-Yang; Tseng, Chih-Yi; Tseng, Fan-Chuan; Lin, Cathy S

    2013-09-01

    Affordances refer to how interface features of an IT artifact, perceived by its users in terms of their potentials for action, may predict the intensity of usage. This study investigates three social information affordances for expressive information control, privacy information control, and image information control in Facebook. The results show that the three affordances can significantly explain how Facebook's interface designs facilitate users' self-presentation activities. In addition, the findings reveal that males are more engaged in expressing information than females, while females are more involved in privacy control than males. A practical application of our study is to compare and contrast the level of affordances offered by various social network sites (SNS) like Facebook and Twitter, as well as differences in online self-presentations across cultures. Our approach can therefore be useful to investigate how SNS design features can be tailored to specific gender and culture needs.

  7. Using Model-Based System Engineering to Provide Artifacts for NASA Project Life-Cycle and Technical Reviews Presentation

    Science.gov (United States)

    Parrott, Edith L.; Weiland, Karen J.

    2017-01-01

    This is the presentation for the AIAA Space conference in September 2017. It highlights key information from Using Model-Based Systems Engineering to Provide Artifacts for NASA Project Life-cycle and Technical Reviews paper.

  8. Recommendations on presenting LHC searches for missing transverse energy signals using simplified s-channel models of dark matter

    DEFF Research Database (Denmark)

    Boveia, Antonio; Buchmueller, Oliver; Busoni, Giorgio

    2016-01-01

    This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on $s$-channel simplified dark matter models and to compare them to direct (indirect) detection experiments....

  9. Recommendations on presenting LHC searches for missing transverse energy signals using simplified s-channel models of dark matter

    International Nuclear Information System (INIS)

    Boveia, Antonio; Buchmueller, Oliver; Busoni, Giorgio; D' Eramo, Francesco; De Roeck, Albert; De Simone, Andrea; Doglioni, Caterina; Dolan, Matthew J.; Genest, Marie-Helene; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Heisig, Jan; Ippolito, Valerio; Kahlhoefer, Felix; Khoze, Velentin V.; Kulkarni, Sichota; Landsberg, Greg; Lowette, Steven; Malik, Sarah; Mangano, Michelangelo; McCabe, Christopher; Mrenna, Stephen; Pani, Priscilla; Du Pree, Tristan; Riotto, Antonio; Salek, David; Schmidt-Hoberg, Kai; Shepherd, William; Tait, Tim M.P.; Wang, Lian-Tao; Worm, Steven; Zurek, Kathryn

    2016-01-01

    This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on s-channel simplified dark matter models and to compare them to direct (indirect) detection experiments.

  10. Recommendations on presenting LHC searches for missing transverse energy signals using simplified s-channel models of dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Boveia, Antonio [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Antwerp Univ., Wilrijk (Belgium); Buchmueller, Oliver [Imperial College, London (United Kingdom); Busoni, Giorgio [Univ. of Melbourne (Australia); D' Eramo, Francesco [Univ. of California, Santa Cruz, CA (United States); De Roeck, Albert [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Antwerp Univ., Wilrijk (Belgium); De Simone, Andrea [Istituto Nazionale di Fisica Nucleare (INFN), Trieste (Italy); Doglioni, Caterina [Lund Univ. (Sweden); Dolan, Matthew J. [Univ. of Melbourne (Australia); Genest, Marie-Helene [Univ. of Grenoble, Saint-Martin-d' Hares (France); Hahn, Kristian [Northwestern Univ., Evanston, IL (United States); Haisch, Ulrich [Univ. of Oxford (United Kingdom); European Organization for Nuclear Research (CERN), Geneva (Switzerland); Harris, Philip C. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Heisig, Jan [RWTH Aachen Univ. (Germany); Ippolito, Valerio [Harvard Univ., Cambridge, MA (United States); Kahlhoefer, Felix [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Khoze, Velentin V. [Durham Univ. (United Kingdom); Kulkarni, Sichota [Austrian Academy of Sciences, Wien (Austria); Landsberg, Greg [Brown Univ., Providence, RI (United States); Lowette, Steven [Vrije Univ., Amsterdam (Netherlands); Malik, Sarah [Imperial College, London (United Kingdom); Mangano, Michelangelo [European Organization for Nuclear Research (CERN), Geneva (Switzerland); McCabe, Christopher [Univ. of Amsterdam (Netherlands); Mrenna, Stephen [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Pani, Priscilla [Stockholm Univ. (Sweden); du Pree, Tristan [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Riotto, Antonio [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Salek, David [Univ. of Amsterdam (Netherlands); Nikhef, Amsterdam (Netherlands); Schmidt-Hoberg, Kai [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Shepherd, William [Univ. of Copenhagen (Denmark); Tait, Tim M.P. [Univ. of California, Irvine, CA (United States); Wang, Lian-Tao [Univ. of Chicago, IL (United States); Worm, Steven [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL); Zurek, Kathryn [Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-03-14

    This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on s-channel simplified dark matter models and to compare them to direct (indirect) detection experiments.

  11. Recommendations on presenting LHC searches for missing transverse energy signals using simplified $s$-channel models of dark matter

    CERN Document Server

    Boveia, Antonio; Busoni, Giorgio; D'Eramo, Francesco; De Roeck, Albert; De Simone, Andrea; Doglioni, Caterina; Dolan, Matthew J.; Genest, Marie-Helene; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Heisig, Jan; Ippolito, Valerio; Kahlhoefer, Felix; Khoze, Valentin V.; Kulkarni, Suchita; Landsberg, Greg; Lowette, Steven; Malik, Sarah; Mangano, Michelangelo; McCabe, Christopher; Mrenna, Stephen; Pani, Priscilla; Pree, Tristan du; Riotto, Antonio; Salek, David; Schmidt-Hoberg, Kai; Shepherd, William; Tait, Tim M. P.; Wang, Lian-Tao; Worm, Steven; Zurek, Kathryn

    2016-01-01

    This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on $s$-channel simplified dark matter models and to compare them to direct (indirect) detection experiments.

  12. VARIOUS PRESENTATIONS OF HYDATID DISEASE AND THEIR MANAGEMENT : A STUDY AT RIMS, KADAPA, A. P.

    OpenAIRE

    Giridhar; Suresh Babu

    2015-01-01

    Hydatid disease most often involves the liver and lung. Actually it can involve any part of the body but primary extra hepaticopulmonary hydatid cyst are rare and their presentation is sporadic. MATERIALS AND METHODS: A retrospective study of 21 cases of hydatid disease repor ted at RIMS, Kadapa, A . P . from 2012 involving liver, spleen, peritoneal cavity, breast and soft tissues. RESULTS: All the cases are successfully operated without any complicat...

  13. Proposing a Model to present Factors which Affect e-SCM Risk and their Impacts on Organizational Performance

    Directory of Open Access Journals (Sweden)

    ali rajabzadeh ghatari

    2010-03-01

    Full Text Available Companies strive to improve market share, grow corporate profit, and gain strategic advantage. In order to achieve these goals, supply chain competency must be placed at the heart of a company’s business model. Using e-Commerce and information and communication technologies (ICT in today’s changing demands of business has made organizations more responsive and flexible. E-Commerce and Internet have changed the nature of supply chains and re-defined how customers obtain wisdom of products, services, selection, purchasing and using them. Advent of ICT and new business environment has caused emerge of electronic supply chains. This research has proposed a model for presenting factors which affect electronic supply chain’s risk; besides the influence of the risk on financial and non-financial organization’s performance indicators. Studying the influence of the risk on organization’s performance is conducted in a sample of electronic and telecommunication companies. In order to measure these relationships, using correlation and structural equation modeling (SEM techniques proposed that electronic supply chain risk identification and management have significant impact on organization’s performance improvement.

  14. Inferring the past and present connectivity across the range of a North American leaf beetle: combining ecological niche modeling and a geographically explicit model of coalescence.

    Science.gov (United States)

    Dellicour, Simon; Fearnley, Shannon; Lombal, Anicée; Heidl, Sarah; Dahlhoff, Elizabeth P; Rank, Nathan E; Mardulyn, Patrick

    2014-08-01

    The leaf beetle Chrysomela aeneicollis occurs across Western North America, either at high elevation or in small, isolated populations along the coast, and thus has a highly fragmented distribution. DNA sequence data (three loci) were collected from five regions across the species range. Population connectivity was examined using traditional ecological niche modeling, which suggested that gene flow could occur among regions now and in the past. We developed geographically explicit coalescence models of sequence evolution that incorporated a two-dimensional representation of the hypothesized ranges suggested by the niche-modeling estimates. We simulated sequence data according to these models and compared them to observed sequences to identify most probable scenarios regarding the migration history of C. aeneicollis. Our results disagreed with initial niche-modeling estimates by clearly rejecting recent connectivity among regions, and were instead most consistent with a long period of range fragmentation, extending well beyond the last glacial maximum. This application of geographically explicit models of coalescence has highlighted some limitations of the use of climatic variables for predicting the present and past range of a species and has explained aspects of the Pleistocene evolutionary history of a cold-adapted organism in Western North America. © 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.

  15. Parametric study for horizontal steam generator modelling

    Energy Technology Data Exchange (ETDEWEB)

    Ovtcharova, I. [Energoproekt, Sofia (Bulgaria)

    1995-12-31

    In the presentation some of the calculated results of horizontal steam generator PGV - 440 modelling with RELAP5/Mod3 are described. Two nodalization schemes have been used with different components in the steam dome. A study of parameters variation on the steam generator work and calculated results is made in cases with separator and branch.

  16. Parametric study for horizontal steam generator modelling

    Energy Technology Data Exchange (ETDEWEB)

    Ovtcharova, I [Energoproekt, Sofia (Bulgaria)

    1996-12-31

    In the presentation some of the calculated results of horizontal steam generator PGV - 440 modelling with RELAP5/Mod3 are described. Two nodalization schemes have been used with different components in the steam dome. A study of parameters variation on the steam generator work and calculated results is made in cases with separator and branch.

  17. Modelling Groundwater Depletion at Regional and Global Scales: Present State and Future Prospects.

    Science.gov (United States)

    Wada, Yoshihide

    2015-01-01

    Except for frozen water in ice and glaciers, groundwater is the world's largest distributed store of freshwater and has strategic importance to global food and water security. In this paper, the most recent advances quantifying groundwater depletion (GWD) are comprehensively reviewed. This paper critically evaluates the recently advanced modeling approaches estimating GWD at regional and global scales, and the evidence of feedbacks to the Earth system including sea-level rise associated with GWD. Finally, critical challenges and opportunities in the use of groundwater are identified for the adaption to growing food demand and uncertain climate.

  18. Building trusted national identity management systems: Presenting the privacy concern-trust (PCT) model

    DEFF Research Database (Denmark)

    Adjei, Joseph K.; Olesen, Henning

    This paper discusses the effect of trust and information privacy concerns on citizens’ attitude towards national identity management systems. We introduce the privacyconcerns- trust model, which shows the role of trust in mediating and moderating citizens’ attitude towards identity management...... systems. We adopted a qualitative research approach in our analysis of data that was gathered through a series of interviews and a stakeholder workshop in Ghana. Our findings indicate that, beyond the threshold level of trust, societal information privacy concern is low; hence, trust is high, thereby...

  19. Clinical presentation and visual status of retinitis pigmentosa patients: a multicenter study in southwestern Nigeria

    Directory of Open Access Journals (Sweden)

    Onakpoya OH

    2016-08-01

    Full Text Available Oluwatoyin Helen Onakpoya,1 Caroline Olufunlayo Adeoti,2 Tunji Sunday Oluleye,3 Iyiade Adeseye Ajayi,4 Timothy Majengbasan,4,5 Olayemi Kolawole Olorundare1 1Department of Ophthalmology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, 2Department of Ophthalmology, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, 3Department of Ophthalmology, University College Hospital, Ibadan, 4Department of Ophthalmology, University Teaching Hospital, Ado-Ekiti, 5Department of Ophthalmology, Federal Medical Centre, Ido-Ekiti, Nigeria Background: To review the visual status and clinical presentation of patients with retinitis pigmentosa (RP.Methodology: Multicenter, retrospective, and analytical review was conducted of the visual status and clinical characteristics of patients with RP at first presentation from January 2007 to December 2011. Main outcome measure was the World Health Organization’s visual status classification in relation to sex and age at presentation. Data analysis by SPSS (version 15 and statistical significance was assumed at P<0.05.Results: One hundred and ninety-two eyes of 96 patients with mean age of 39.08±18.5 years and mode of 25 years constituted the study population; 55 (57.3% were males and 41 (42.7% females. Loss of vision 67 (69.8% and night blindness 56 (58.3% were the leading symptoms. Twenty-one (21.9% patients had a positive family history, with RP present in their siblings 15 (71.4%, grandparents 11 (52.3%, and parents 4 (19.4%. Forty (41.7% were blind at presentation and 23 (24% were visually impaired. Blindness in six (15% patients was secondary to glaucoma. Retinal vascular narrowing and retinal pigmentary changes of varying severity were present in all patients. Thirty-five (36.5% had maculopathy, 36 (37.5% refractive error, 19 (20% lenticular opacities, and eleven (11.5% had glaucoma. RP was typical in 85 patients (88.5%. Older patients had higher rates of blindness at presentation (P=0

  20. Urban Studies: A Learning Model.

    Science.gov (United States)

    Cooper, Terry L.; Sundeen, Richard

    1979-01-01

    The urban studies learning model described in this article was found to increase students' self-esteem, imbue a more flexible and open perspective, contribute to the capacity for self-direction, produce increases on the feeling reactivity, spontaneity, and acceptance of aggression scales, and expand interpersonal competence. (Author/WI)

  1. Campus network security model study

    Science.gov (United States)

    Zhang, Yong-ku; Song, Li-ren

    2011-12-01

    Campus network security is growing importance, Design a very effective defense hacker attacks, viruses, data theft, and internal defense system, is the focus of the study in this paper. This paper compared the firewall; IDS based on the integrated, then design of a campus network security model, and detail the specific implementation principle.

  2. Feasibility study of computerized presentation of procedures of a nuclear plant

    International Nuclear Information System (INIS)

    Takagawa, Kenichi; Niwa, Yuji; Urakami, Masahiro

    2010-01-01

    Introduction of a digital instrumentation control system is in progress in recent nuclear power plants, and an application of Computer Based Procedures (CBP) is being considered. The Institute of Nuclear Safety System, Incorporated has developed a system for a Computerized Presentation of Procedures (CPP) which corresponds to CBP. By fiscal year 2002, all items in the emergency operation procedures of a model plant were made displayable on the CPP. In 2003, the CPP instead of the paper based procedures was used for trial by the operators of a nuclear power plant in an actual training simulator, and feasibility of its practical application was evaluated. Based on the result, we considered subjects which should be taken into account in the future. As a result, improvements of CPP and its navigation system, etc. to enable operations with multi-procedures in parallel were extracted as primary subjects for introduction of CBP in the future as well as practical application of CPP. (author)

  3. Statistical modelling of grapevine yield in the Port Wine region under present and future climate conditions

    Science.gov (United States)

    Santos, João A.; Malheiro, Aureliano C.; Karremann, Melanie K.; Pinto, Joaquim G.

    2011-03-01

    The impact of projected climate change on wine production was analysed for the Demarcated Region of Douro, Portugal. A statistical grapevine yield model (GYM) was developed using climate parameters as predictors. Statistically significant correlations were identified between annual yield and monthly mean temperatures and monthly precipitation totals during the growing cycle. These atmospheric factors control grapevine yield in the region, with the GYM explaining 50.4% of the total variance in the yield time series in recent decades. Anomalously high March rainfall (during budburst, shoot and inflorescence development) favours yield, as well as anomalously high temperatures and low precipitation amounts in May and June (May: flowering and June: berry development). The GYM was applied to a regional climate model output, which was shown to realistically reproduce the GYM predictors. Finally, using ensemble simulations under the A1B emission scenario, projections for GYM-derived yield in the Douro Region, and for the whole of the twenty-first century, were analysed. A slight upward trend in yield is projected to occur until about 2050, followed by a steep and continuous increase until the end of the twenty-first century, when yield is projected to be about 800 kg/ha above current values. While this estimate is based on meteorological parameters alone, changes due to elevated CO2 may further enhance this effect. In spite of the associated uncertainties, it can be stated that projected climate change may significantly benefit wine yield in the Douro Valley.

  4. Testing a Poisson Counter Model for Visual Identification of Briefly Presented, Mutually Confusable Single Stimuli in Pure Accuracy Tasks

    Science.gov (United States)

    Kyllingsbaek, Soren; Markussen, Bo; Bundesen, Claus

    2012-01-01

    The authors propose and test a simple model of the time course of visual identification of briefly presented, mutually confusable single stimuli in pure accuracy tasks. The model implies that during stimulus analysis, tentative categorizations that stimulus i belongs to category j are made at a constant Poisson rate, v(i, j). The analysis is…

  5. Summarized presentation of the numerical model used for the pressurizer of a light water nuclear reactor. Description and validation

    International Nuclear Information System (INIS)

    Siarry, P.

    1981-12-01

    The pressurizer model is first described together with its coupling to the nuclear unit. The different stages involved in the validation are then presented: validation of overall qualitative behavior; validation of the open loop pressurizer model; validation of the various units for controlling pressures and levels; simulation of two large transients (Bugey plant) [fr

  6. ED Triage Decision-Making With Mental Health Presentations: A "Think Aloud" Study.

    Science.gov (United States)

    Clarke, Diana E; Boyce-Gaudreau, Krystal; Sanderson, Ana; Baker, John A

    2015-11-01

    Triage is the process whereby persons presenting to the emergency department are quickly assessed by a nurse and their need for care and service is prioritized. Research examining the care of persons presenting to emergency departments with psychiatric and mental health problems has shown that triage has often been cited as the most problematic aspect of the encounter. Three questions guided this investigation: Where do the decisions that triage nurses make fall on the intuitive versus analytic dimensions of decision making for mental health presentations in the emergency department, and does this differ according to comfort or familiarity with the type of mental health/illness presentation? How do "decision aids" (i.e., structured triage scales) help in the decision-making process? To what extent do other factors, such as attitudes, influence triage nurses' decision making? Eleven triage nurses participating in this study were asked to talk out loud about the reasoning process they would engage in while triaging patients in 5 scenarios based on mental health presentations to the emergency department. Themes emerging from the data were tweaking the results (including the use of intuition and early judgments) to arrive at the desired triage score; consideration of the current ED environment; managing uncertainty and risk (including the consideration of physical reasons for presentation); and confidence in communicating with patients in distress and managing their own emotive reactions to the scenario. Findings support the preference for using the intuitive mode of decision making with only tacit reliance on the decision aid. Copyright © 2015 Emergency Nurses Association. Published by Elsevier Inc. All rights reserved.

  7. A comparison by stochastic models between present-day and last-century temperature in Udine

    International Nuclear Information System (INIS)

    Ceschia, M.; Garfagnini, R.; Toppano, E.

    1987-01-01

    In this paper the daily average temperatures recorded in Udine in the years 1868, 1869, 1870, 1871, 1876, 1976, 1980, 1981, 1984 and 1985 (for which an integral set of reliable and comparable-data was at disposal) have been analysed. The main purposes of this work are: look for characteristic periodicities in the series of data, analyse the background erratic component by means of stochastic methods and look for possible differences between the temperature of the last century and those of the present

  8. Mining Product Data Models: A Case Study

    Directory of Open Access Journals (Sweden)

    Cristina-Claudia DOLEAN

    2014-01-01

    Full Text Available This paper presents two case studies used to prove the validity of some data-flow mining algorithms. We proposed the data-flow mining algorithms because most part of mining algorithms focuses on the control-flow perspective. First case study uses event logs generated by an ERP system (Navision after we set several trackers on the data elements needed in the process analyzed; while the second case study uses the event logs generated by YAWL system. We offered a general solution of data-flow model extraction from different data sources. In order to apply the data-flow mining algorithms the event logs must comply a certain format (using InputOutput extension. But to respect this format, a set of conversion tools is needed. We depicted the conversion tools used and how we got the data-flow models. Moreover, the data-flow model is compared to the control-flow model.

  9. Neural activity induced by visual food stimuli presented out of awareness: a preliminary magnetoencephalography study.

    Science.gov (United States)

    Takada, Katsuko; Ishii, Akira; Matsuo, Takashi; Nakamura, Chika; Uji, Masato; Yoshikawa, Takahiro

    2018-02-15

    Obesity is a major public health problem in modern society. Appetitive behavior has been proposed to be partially driven by unconscious decision-making processes and thus, targeting the unconscious cognitive processes related to eating behavior is essential to develop strategies for overweight individuals and obese patients. Here, we presented food pictures below the threshold of awareness to healthy male volunteers and examined neural activity related to appetitive behavior using magnetoencephalography. We found that, among participants who did not recognize food pictures during the experiment, an index of heart rate variability assessed by electrocardiography (low-frequency component power/high-frequency component power ratio, LF/HF) just after picture presentation was increased compared with that just before presentation, and the increase in LF/HF was negatively associated with the score for cognitive restraint of food intake. In addition, increased LF/HF was negatively associated with increased alpha band power in Brodmann area (BA) 47 caused by food pictures presented below the threshold of awareness, and level of cognitive restraint was positively associated with increased alpha band power in BA13. Our findings may provide valuable clues to the development of methods assessing unconscious regulation of appetite and offer avenues for further study of the neural mechanisms related to eating behavior.

  10. Presentation and management of keloid scarring following median sternotomy: a case study

    Directory of Open Access Journals (Sweden)

    Javangula Kalyana C

    2010-12-01

    Full Text Available Abstract Introduction Keloid scars following median sternotomy are rare and occur more frequently in pigmented skin. Different management strategies have been described with variable success. We present a case of keloid scar formation following cardiac surgery including our management and the final aesthetic result. Case description A 64 year old female of fair complexion underwent mitral valve replacement. The procedure and postoperative recovery were uncomplicated, however, during the following year, thick keloid scars formed over the incision sites. Initial non surgical measures failed to relieve pain and did not offer any tangible aesthetic benefit. Eventually surgical excision was attempted. She presented to our clinic for nine months follow up with significant improvement in pain and aesthetic result. Discussion and Evaluation Several theories have attempted to explore the pathophysiology of keloid scar formation. A number of predisposing factors have been documented however none existed in this case. A variety of invasive and non invasive approaches have been described but significant differences in success rates and methodology of investigations still precludes a standardized management protocol. Conclusions In this case study a rare presentation of keloid scar has been presented. The variety of methods used to improve pain and aesthetic result demonstrates the propensity of keloid scars to recur and the therapeutic challenges that surgeons have to face in their quest for a satisfactory patient outcome.

  11. Clinical Presentation of Soft-tissue Infections and its Management: A Study of 100 Cases.

    Science.gov (United States)

    Singh, Baldev; Singh, Sukha; Khichy, Sudhir; Ghatge, Avinash

    2017-01-01

    Soft-tissue infections vary widely in their nature and severity. A clear approach to the management must allow their rapid identification and treatment as they can be life-threatening. Clinical presentation of soft-tissue infections and its management. A prospective study based on 100 patients presenting with soft-tissue infections was done. All the cases of soft-tissue infections were considered irrespective of age, sex, etiological factors, or systemic disorders. The findings were evaluated regarding the pattern of soft-tissue infections in relation to age and sex, clinical presentation, complications, duration of hospital stay, management, and mortality. The most commonly involved age group was in the range of 41-60 years with male predominance. Abscess formation (45%) was the most common clinical presentation. Type 2 diabetes mellitus was the most common associated comorbid condition. Staphylococcus aureus was the most common culture isolate obtained. The most common complication seen was renal failure. Patients with surgical site infections had maximum duration of stay in the hospital. About 94% of the cases of soft-tissue infections were managed surgically. Mortality was mostly encountered in the cases of complications of cellulitis. Skin and soft-tissue infections are among the most common infections encountered by the emergency physicians. Ignorance, reluctance to treatment, economic constraints, and illiteracy delay the early detection and the initiation of proper treatment. Adequate and timely surgical intervention in most of the cases is of utmost importance to prevent the complications and reduce the mortality.

  12. Pesticides in groundwater: modelling and data analysis of the past, present and future

    DEFF Research Database (Denmark)

    Binning, Philip John; McKnight, Ursula S.; Malaguerra, Flavio

    Pesticides are the most frequently detected groundwater contaminants in Denmark. However, there is still a great deal of debate about the fate of pesticides and their future occurrence in our environment. We do not really understand the link between past usage and current observations, and are no......Pesticides are the most frequently detected groundwater contaminants in Denmark. However, there is still a great deal of debate about the fate of pesticides and their future occurrence in our environment. We do not really understand the link between past usage and current observations...... to jointly manage our groundwater and surface water resources. Here, observed pesticide data is analyzed and combined with models to address these questions and needs. Groundwater and surface water pesticide observations reflect the fact that these two hydrological components have a strong interaction...

  13. Modeling laser speckle imaging of perfusion in the skin (Conference Presentation)

    Science.gov (United States)

    Regan, Caitlin; Hayakawa, Carole K.; Choi, Bernard

    2016-02-01

    Laser speckle imaging (LSI) enables visualization of relative blood flow and perfusion in the skin. It is frequently applied to monitor treatment of vascular malformations such as port wine stain birthmarks, and measure changes in perfusion due to peripheral vascular disease. We developed a computational Monte Carlo simulation of laser speckle contrast imaging to quantify how tissue optical properties, blood vessel depths and speeds, and tissue perfusion affect speckle contrast values originating from coherent excitation. The simulated tissue geometry consisted of multiple layers to simulate the skin, or incorporated an inclusion such as a vessel or tumor at different depths. Our simulation used a 30x30mm uniform flat light source to optically excite the region of interest in our sample to better mimic wide-field imaging. We used our model to simulate how dynamically scattered photons from a buried blood vessel affect speckle contrast at different lateral distances (0-1mm) away from the vessel, and how these speckle contrast changes vary with depth (0-1mm) and flow speed (0-10mm/s). We applied the model to simulate perfusion in the skin, and observed how different optical properties, such as epidermal melanin concentration (1%-50%) affected speckle contrast. We simulated perfusion during a systolic forearm occlusion and found that contrast decreased by 35% (exposure time = 10ms). Monte Carlo simulations of laser speckle contrast give us a tool to quantify what regions of the skin are probed with laser speckle imaging, and measure how the tissue optical properties and blood flow affect the resulting images.

  14. Co-morbidities in children presenting with chronic suppurative otitis media--a South African study.

    Science.gov (United States)

    Hallbauer, Ute M; Atkins, Mark D; Tiedt, Nicholas J; Butler, Iain R T; Pieters, Madeleine; Elliott, Eugene; Joubert, Gina; Seedat, Riaz Y

    2014-06-01

    Chronic suppurative otitis media (CSOM) is common among children in southern Africa. Managing associated co-morbidities may result in earlier disease resolution. Children 4 weeks were recruited to the study. Each child underwent a full clinical examination, a blood count, an HIV test and CD4 cell count, if found to be infected. The study included 86 children, and the median age was 4.6 years. HIV infection was present in 45 of 83 children (54.2%), of which 23 (51.1%) were receiving antiretroviral treatment at the time of presentation. Underweight was present in 22 of 85 (25.9%) children and in 17 of the 45 (37.8%) HIV-infected children. One or more clinical signs (not aural-related) were found in 46 of 86 (53.4%) children. Cholesteatoma was found in 23 of 113 (20.4%) ears, and 9 of 86 (10.5%) children had serious associated aural or intracranial complications. A high percentage of children with CSOM have associated pathology that needs to be diagnosed to optimally manage CSOM. © The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  15. Multi-Decadal Variability in the Bering Sea: A Synthesis of Model Results and Observations from 1948 to the Present

    Science.gov (United States)

    2013-12-01

    stated that the development and use of high-resolution Arctic climate and systems models are important stepping stones for dedicated studies of...W., J. L. Clement Kinney, D. C. Marble , and J. Jakacki, 2008: Towards eddy resolving models of the Arctic Ocean: Ocean Modeling in an Eddying

  16. External cephalic version for breech presentation at term. A prospective interventional study.

    Science.gov (United States)

    Al-Jwadi, Saja A; Al-Ibrahim, Baraa L Humo

    2014-08-01

    To evaluate the external cephalic version (ECV) procedure for the management of at term breech presenting fetuses. In this prospective, interventional study, 90 patients with uncomplicated breech presentations at or after 37 weeks' gestation were considered for ECV. This was performed in Al-Batool Teaching Hospital, Mosul, Iraq, between January 2011 and March 2012. The main outcome measure was assessed as the success rate of ECV attempt and the rate of cesarean section following a successful procedure. Parity, type of breech, placental location, and birth weight were evaluated as predictors of success. Also, any fetal or maternal complications during the procedure were evaluated. Data were analyzed by x2 test. Statistical significance was determined at a level of pbreech. There were no serious fetal or maternal complications associated with the attempt. With appropriate selection of patients, ECV is highly successful and is a safer alternative to vaginal breech delivery or cesarean delivery.

  17. A comparative study on thermal efficiency between the present floor and a ceramic floor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Y.M.; Kim, K.S. [Korea Institute of Science and Technology, Seoul (Korea, Republic of); Choi, B.S. [Kyung Hee University, Yongin (Korea, Republic of); Ko, J.S.; Park, S.K. [Bomwoo and Co. LTD., Kwangju (Korea, Republic of)

    1999-04-01

    A ceramic floor with improved thermal conductivity and efficiency has been developed in this study. The new ceramic floor minimizes the shrinkage rate to below 0.07% and shows almost no cleavage. There is no need to repair the ceramic floor because its bottom surface is flat. It especially shows an excellent performance in the test of a compressive strength (300 kg/cm{sup 2} based on 28 days), a flexural strength (64 kg/cm{sup 2} based on 28 days), and a convenient pressing. It is lighter than the present floor and it is expected to be applicable for a self-leveling ceramic motar in the residences and apartments. It shows an excellent character in the thermal conductivity and other physical properties compare to the present cement mortar. 5 refs., 3 figs., 2 tabs.

  18. Frequency and echocardiographic study of dilated cardiomyopathy in children presenting with cardiac failure

    International Nuclear Information System (INIS)

    Khan, M.A.; Mohammad, J.; Hussain, M.

    2004-01-01

    Objective: To evaluate the role of echocardiography in diagnosis of dilated cardiomyopathy as a cause of cardiac failure in children. Design: This was descriptive study. Children presenting with cardiac failure from indoor patients were selected and echocardiography along with chest X- ray, ECG, cardiac enzymes and ASO titre was performed in all patients. Subject: Fifty hospitalized patients with congestive heart failure were selected consecutively from hospitalized patients. Main Outcome: Role of echocardiography in the diagnosis of dilated cardiomyopathy in children presenting with cardiac failure. Results: Out of fifty patients admitted with cardiac failure 27 (54%) cases were found to be dilated cardiomyopathy while congenital heart disease, myocarditis and rheumatic heart disease were found in 12 (24%), 8 (16%) and 3 (6%) cases respectively. Conclusion: Dilated cardiomyopathy is an important cause of cardiac failure in children and echocardiography is an important tool to diagnose and differentiate dilated cardiomyopathy from other causes of cardiac failure. (author)

  19. Stage at presentation of breast cancer in Luanda, Angola - a retrospective study.

    Science.gov (United States)

    Lopes, Lygia Vieira; Miguel, Fernando; Freitas, Helga; Tavares, António; Pangui, Salvador; Castro, Clara; Lacerda, Gonçalo Forjaz; Longatto-Filho, Adhemar; Weiderpass, Elisabete; Santos, Lúcio Lara

    2015-10-15

    It is expected that, by 2020, 15 million new cases of cancer will occur every year in the world, one million of them in Africa. Knowledge of cancer trends in African countries is far from adequate, and improvements in cancer prevention efforts are urgently needed. The aim of this study was to characterize breast cancer clinically and pathologically at presentation in Luanda, Angola; we additionally provide quality information that will be useful for breast cancer care planning in the country. Data on breast cancer cases were retrieved from the Angolan Institute of Cancer Control, from 2006 to 2014. For women diagnosed in 2009 (5-years of follow-up), demographic, clinical and pathological information, at presentation, was collected, namely age at diagnosis, parity, methods used for pathological diagnoses, tumor pathological characteristics, stage of disease and treatment. Descriptive statistics were performed. The median age of women diagnosed with breast cancer in 2009 was 47 years old (range 25-89). The most frequent clinical presentation was breast swelling with axillary lymph nodes metastasis (44.9 %), followed by a mass larger than 5 cm (14.2 %) and lump (12.9 %). Invasive ductal carcinoma was the main histologic type (81.8 %). Only 10.1 % of cancer cases had a well differentiated histological grade. Cancers were diagnosed mostly at advanced stages (66.7 % in stage III and 11.1 % in stage IV). In this study, breast cancer was diagnosed at a very advanced stage. Although it reports data from a single cancer center in Luanda, Angola it reinforces the need for early diagnosis and increasing awareness. According to the main challenges related to breast cancer diagnosis and treatment herein presented, we propose a realistic framework that would allow for the implementation of a breast cancer care program, built under a strong network based on cooperation, teaching, audit, good practices and the organization of health services. Angola needs urgently a program for

  20. A mathematical model of past, present and future shore level displacement in Fennoscandia

    Energy Technology Data Exchange (ETDEWEB)

    Paasse, T. [Sveriges Geologiska Undersoekning, Goeteborg (Sweden)

    1997-12-01

    Shore level displacement in Fennoscandia is mainly due to two interactive vertical movements, glacio-isostatic uplift and eustatic sea level rise. A recent investigation of the lake-tilting phenomenon has made it possible to discern the course of glacio-isostatic. As a consequence an iteration process to estimate glacio-isostatic uplift and eustatic rise using empirical data of the shore level displacement has been started. The model indicates that there are two mechanisms involved in glacio-isostatic uplift, one slow and the other fast. The main uplift, still in progress, acts slowly. Arctan functions have proved to be suitable tools for describing slow glacio-isostatic uplift. The time of maximal uplift rate is isochronous, meaning that slow uplift occurred simultaneously in all Fennoscandia in an interactive movement. For slow uplift there is a relationship between the rate of decline and the crustal thickness. In areas with greater crustal thickness the rate of decline of the glacio-isostatic recovery is lower than in areas with thinner crust. The fast mechanism gave rise to a crustal subsidence which started about 12 500 BP. After about 10 300 BP, in the early Holocene, the subsidence was restored by a fast uplift. Normal distribution functions have been used for calculating the fast mechanism. The mantle material exhibits plastic behaviour. When the mantle encounters short-lived stresses the material behaves like an elastic solid but in response to long-term stresses it will flow. The slow mechanism can be linked to viscous flow and as a response to long-term stresses. The fast mechanism is probably the response to a short-lived stress. This stress could have been caused by renewed ice loading, due to a self-triggered redistribution of the ice load during deglaciation. Future development regarding glacio-isostatic uplift, eustasy and shore level displacement is predicted in Fennoscandia using the results from the modelling. Predictions are based on the

  1. An interactive boundary layer modeling methodology for aerodynamic flows[Presentation

    CSIR Research Space (South Africa)

    Smith, L

    2011-11-01

    Full Text Available the Goldstein singularity without the need to solve the entire flow domain simultaneously. In this work the incompressible Navier- Stokes equations will be used for the outer flow. In the majority of previous studies the boundary layer thickness is simulated...

  2. Defects in Antigen-Presenting Cells in the BB-DP Rat Model of Diabetes

    NARCIS (Netherlands)

    V. Sommandas (Vinod)

    2008-01-01

    textabstractType-1 diabetes is the result of a T cell mediated immune response against the insulin-producing β cells in the islet of Langerhans. In humans, until now, the disease is only clearly detectable at the onset of the disease. Therefore studies to identify initial factors involved in

  3. Prospective study of POLG mutations presenting in children with intractable epilepsy: prevalence and clinical features.

    Science.gov (United States)

    Uusimaa, Johanna; Gowda, Vasantha; McShane, Anthony; Smith, Conrad; Evans, Julie; Shrier, Annie; Narasimhan, Manisha; O'Rourke, Anthony; Rajabally, Yusuf; Hedderly, Tammy; Cowan, Frances; Fratter, Carl; Poulton, Joanna

    2013-06-01

    To assess the frequency and clinical features of childhood-onset intractable epilepsy caused by the most common mutations in the POLG gene, which encodes the catalytic subunit of mitochondrial DNA polymerase gamma. Children presenting with nonsyndromic intractable epilepsy of unknown etiology but without documented liver dysfunction at presentation were eligible for this prospective, population-based study. Blood samples were analyzed for the three most common POLG mutations. If any of the three tested mutations were found, all the exons and the exon-intron boundaries of the POLG gene were sequenced. In addition, we retrospectively reviewed the notes of patients presenting with intractable epilepsy in which we had found POLG mutations. All available clinical data were collected by questionnaire and by reviewing the medical records. We analyzed 213 blood DNA samples from patients fulfilling the inclusion criteria of the prospective study. Among these, five patients (2.3%) were found with one of the three common POLG mutations as homozygous or compound heterozygous states. In addition, three patients were retrospectively identified. Seven of the eight patients had either raised cerebrospinal fluid (CSF) lactate (n = 3) or brain magnetic resonance imaging (MRI) changes (n = 4) at presentation with intractable epilepsy. Three patients later developed liver dysfunction, progressing to fatal liver failure in two without previous treatment with sodium valproate (VPA). Furthermore, it is worth mentioning that one patient presented first with an autism spectrum disorder before seizures emerged. Mutations in POLG are an important cause of early and juvenile onset nonsyndromic intractable epilepsy with highly variable associated manifestations including autistic features. This study emphasizes that genetic testing for POLG mutations in patients with nonsyndromic intractable epilepsies is very important for clinical diagnostics, genetic counseling, and treatment decisions

  4. Optical coherence tomography noise modeling and fundamental bounds on human retinal layer segmentation accuracy (Conference Presentation)

    Science.gov (United States)

    DuBose, Theodore B.; Milanfar, Peyman; Izatt, Joseph A.; Farsiu, Sina

    2016-03-01

    The human retina is composed of several layers, visible by in vivo optical coherence tomography (OCT) imaging. To enhance diagnostics of retinal diseases, several algorithms have been developed to automatically segment one or more of the boundaries of these layers. OCT images are corrupted by noise, which is frequently the result of the detector noise and speckle, a type of coherent noise resulting from the presence of several scatterers in each voxel. However, it is unknown what the empirical distribution of noise in each layer of the retina is, and how the magnitude and distribution of the noise affects the lower bounds of segmentation accuracy. Five healthy volunteers were imaged using a spectral domain OCT probe from Bioptigen, Inc, centered at 850nm with 4.6µm full width at half maximum axial resolution. Each volume was segmented by expert manual graders into nine layers. The histograms of intensities in each layer were then fit to seven possible noise distributions from the literature on speckle and image processing. Using these empirical noise distributions and empirical estimates of the intensity of each layer, the Cramer-Rao lower bound (CRLB), a measure of the variance of an estimator, was calculated for each boundary layer. Additionally, the optimum bias of a segmentation algorithm was calculated, and a corresponding biased CRLB was calculated, which represents the improved performance an algorithm can achieve by using prior knowledge, such as the smoothness and continuity of layer boundaries. Our general mathematical model can be easily adapted for virtually any OCT modality.

  5. Development of Concepts and Models of Performance Evaluation from the 19th Century to the Present

    Directory of Open Access Journals (Sweden)

    Hornungová Jana

    2014-07-01

    Full Text Available The main aim of this paper is to provide a framework of concepts and models from the area of performance measurement. Due to the fact that the business environment is con-stantly changing, changes also occur in the trends relating to performance. Traditional financial performance measures have been highly criticized and the need identified to integrate non-financial perspectives, such as level of innovation, degree of motivation, intellectual capital and other criteria. Intellectual capital is often a crucial factor in the creation of value in a company. This paper provides a literature review supplemented by the author’s research in the field of performance. The article shows that the performance appraisal system is currently focused on several areas that could affect the performance of the company, which is also part of the overall performance of the economy in the form of GDP growth. Based on the research, it can be said that, for the sample tracked, the selection of performance evaluation system does not depend on the legal form of the business.

  6. In vivo perfusion assessment of an anastomosis surgery on porcine intestinal model (Conference Presentation)

    Science.gov (United States)

    Le, Hanh N. D.; Opferman, Justin; Decker, Ryan; Cheon, Gyeong W.; Kim, Peter C. W.; Kang, Jin U.; Krieger, Axel

    2016-04-01

    Anastomosis, the connection of two structures, is a critical procedure for reconstructive surgery with over 1 million cases/year for visceral indication alone. However, complication rates such as strictures and leakage affect up to 19% of cases for colorectal anastomoses and up to 30% for visceral transplantation anastomoses. Local ischemia plays a critical role in anastomotic complications, making blood perfusion an important indicator for tissue health and predictor for healing following anastomosis. In this work, we apply a real time multispectral imaging technique to monitor impact on tissue perfusion due to varying interrupted suture spacing and suture tensions. Multispectral tissue images at 470, 540, 560, 580, 670 and 760 nm are analyzed in conjunction with an empirical model based on diffuse reflectance process to quantify the hemoglobin oxygen saturation within the suture site. The investigated tissues for anastomoses include porcine small (jejunum and ileum) and large (transverse colon) intestines. Two experiments using interrupted suturing with suture spacing of 1, 2, and 3 mm and tension levels from 0 N to 2.5 N are conducted. Tissue perfusion at 5, 10, 20 and 30 min after suturing are recorded and compared with the initial normal state. The result indicates the contrast between healthy and ischemic tissue areas and assists the determination of suturing spacing and tension. Therefore, the assessment of tissue perfusion will permit the development and intra-surgical monitoring of an optimal suture protocol during anastomosis with less complications and improved functional outcome.

  7. Vaginal hemodynamic changes during sexual arousal in a rat model by diffuse optical spectroscopy (Conference Presentation)

    Science.gov (United States)

    Jeong, Hyeryun; Seong, Myeongsu; Lee, Hyun-Suk; Park, Kwangsung; Kim, Jae Gwan

    2017-02-01

    Not only men suffer from sexual dysfunction, but the number of women who have sexual dysfunction rises. Therefore, it is necessary to develop an objective diagnostic technique to examine the sexual dysfunction of female patients, who are afflicted with the disorders. For this purpose, we developed a diffuse optical spectroscopy (DOS) probe to measure the change of oxy-, deoxy-, and total hemoglobin concentration along with blood flow from vaginal wall of female rats. A cylindrical stainless steel DOS probe with a diameter of 3 mm was designed for the vaginal wall of rats which consisted of two lasers (785 and 850nm) and two spectrometers with a separation of 2 mm. A thermistor was placed on the top of the probe to measure the temperature change from vaginal wall during experiments. A modified Beer-Lambert's law is utilized to acquire the changes of oxy-, deoxy-, and total hemoglobin, and blood flow information is obtained by diffuse speckle contrast analysis technique. For the experiments, Sprague Dawley ( 400 g) female rats were divided into two groups (control and vaginal dryness model). Vaginal oxygenation, blood flow and temperature were continuously monitored before and after sexual around induced by apomorphine. After the measurement, histologic examination was performed to support the results from DOS probe in the vaginal wall. The hemodynamic information acquired by the DOS probe can be utilized to establish an objective and accurate standard of the female sexual disorders.

  8. Studying time of flight imaging through scattering media across multiple size scales (Conference Presentation)

    Science.gov (United States)

    Velten, Andreas

    2017-05-01

    Light scattering is a primary obstacle to optical imaging in a variety of different environments and across many size and time scales. Scattering complicates imaging on large scales when imaging through the atmosphere when imaging from airborne or space borne platforms, through marine fog, or through fog and dust in vehicle navigation, for example in self driving cars. On smaller scales, scattering is the major obstacle when imaging through human tissue in biomedical applications. Despite the large variety of participating materials and size scales, light transport in all these environments is usually described with very similar scattering models that are defined by the same small set of parameters, including scattering and absorption length and phase function. We attempt a study of scattering and methods of imaging through scattering across different scales and media, particularly with respect to the use of time of flight information. We can show that using time of flight, in addition to spatial information, provides distinct advantages in scattering environments. By performing a comparative study of scattering across scales and media, we are able to suggest scale models for scattering environments to aid lab research. We also can transfer knowledge and methodology between different fields.

  9. Residential traffic exposure and children's emergency department presentation for asthma: a spatial study

    Directory of Open Access Journals (Sweden)

    Pereira Gavin

    2009-11-01

    Full Text Available Abstract Background There is increasing evidence that residential proximity to roadways is associated with an elevated risk of asthma exacerbation. However, there is no consensus on the distance at which these health effects diminishes to background levels. Therefore the optimal, clinically relevant measure of exposure remains uncertain. Using four spatially defined exposure metrics, we evaluated the association between residential proximity to roadways and emergency department (ED presentation for asthma in Perth, Western Australia. Method The study population consisted of 1809 children aged between 0 and 19 years who had presented at an ED between 2002 and 2006 and were resident in a south-west metropolitan area of Perth traversed by major motorways. We used a 1:2 matched case-control study with gastroenteritis and upper limb injury as the control conditions. To estimate exposure to traffic emissions, we used 4 contrasting methods and 2 independently derived sources of traffic data (video-monitored traffic counts and those obtained from the state government road authority. The following estimates of traffic exposure were compared: (1 a point pattern method, (2 a distance-weighted traffic exposure method, (3 a simple distance method and (4 a road length method. Results Risk estimates were sensitive to socio-economic gradients and the type of exposure method that was applied. Unexpectedly, a range of apparent protective effects were observed for some exposure metrics. The kernel density measure demonstrated more than a 2-fold (OR 2.51, 95% CI 2.00 - 3.15 increased risk of asthma ED presentation for the high exposure group compared to the low exposure group. Conclusion We assessed exposure using traffic data from 2 independent sources and compared the results of 4 different exposure metric types. The results indicate that traffic congestion may be one of the most important aspects of traffic-related exposures, despite being overlooked in many

  10. Coffin-Siris syndrome: review and presentation of new cases from a questionnaire study.

    Science.gov (United States)

    Fleck, B J; Pandya, A; Vanner, L; Kerkering, K; Bodurtha, J

    2001-02-15

    To clarify the phenotypic variability of Coffin-Siris syndrome, we present a review of the literature and 18 new cases. We performed a questionnaire study of patients ascertained through an international support group. Information on their sibs was available for comparison. The most frequent findings include some degree of mental retardation or developmental delay, "coarse" facial appearance, feeding difficulties, frequent infections, and hypoplastic to absent fifth fingernails and fifth distal phalanges. We discuss the key manifestations for diagnosis, medical and developmental implications, and possible pathogenesis. Copyright Wiley-Liss. Inc.

  11. Kuala Kemaman hydraulic model study

    International Nuclear Information System (INIS)

    Abdul Kadir Ishak

    2005-01-01

    There The problems facing the area of Kuala Kemaman are siltation and erosion at shoreline. The objectives of study are to assess the best alignment of the groyne alignment, to ascertain the most stable shoreline regime and to investigate structural measures to overcome the erosion. The scope of study are data collection, wave analysis, hydrodynamic simulation and sediment transport simulation. Numerical models MIKE 21 are used - MIKE 21 NSW, for wind-wave model, which describes the growth, decay and transformation of wind-generated waves and swell in nearshore areas. The study takes into account effects of refraction and shoaling due to varying depth, energy dissipation due to bottom friction and wave breaking, MIKE 21 HD - modelling system for 2D free-surface flow which to stimulate the hydraulics phenomena in estuaries, coastal areas and seas. Predicted tidal elevation and waves (radiation stresses) are considered into study while wind is not considered. MIKE 21 ST - the system that calculates the rates of non-cohesive (sand) sediment transport for both pure content and combined waves and current situation

  12. Present status of DNA repair mechanisms in uv irradiated yeast taken as a model eukaryotic system

    International Nuclear Information System (INIS)

    Moustacchi, E.; Waters, R.; Heude, M.; Chanet, R.

    1975-01-01

    The repair mechanisms of altered DNA are generally less well understood for eukaryotes than they are for prokaryotes and bacteriophages. For mammalian cell lines cultured in vitro the specific labelling of DNA has allowed the biochemical analysis of some of the steps of the repair processes whereas the determination of their genetic controls is, with a few exceptions, obviously difficult. On the other hand, with fungi and more specifically with yeast taken as a model unicellular eukaryotic system, the genetic approach has been extensively explored: radiosensitive mutants are readily detected and genetically analyzed, double and multiple mutants can be constructed and from their responses to irradiation the number of repair pathways involved can be suggested. The lack of thymidine kinase in these organisms has hampered for a certain time the biochemical analysis of repair. However, the recent isolation of yeast strains capable of taking up and incorporating thymidine 5'-monophosphate into their DNA opens new possibilities for the future. In spite of this difficulty, attempts to measure the induction and removal of uv-induced pyrimidine dimers were performed by several groups during the last three years. The two main repair pathways described for E. coli, i.e., the excision-resynthesis and post-replicative recombinational repair pathways, do exist in yeast. The existence of the former pathway is supported not only by indirect evidence but also by biochemical analysis. The rad 1 and rad 2 mutants for instance have been shown to be blocked in the excision of uv-induced pyrimidine dimers. Other loci are epistatic to rad 1 and rad 2 (rad 3 , rad 4 ) and are likely to act on this excision pathway. The genetic control of the mitochondrial response to a uv treatment involves nuclear genes and mitochondrial determinants

  13. [Lacrimal sac tumors presenting as lacrimal obstruction. Retrospective study in Mexican patients 2007-2012].

    Science.gov (United States)

    Coloma-González, I; Flores-Preciado, J; Ceriotto, A; Corredor-Casas, S; Salcedo-Casillas, G

    2014-06-01

    To determine the demographic and clinical data of primary tumors of the lacrimal sac presenting as lacrimal obstruction. Retrospective and descriptive study was conducted between the years 2007 to 2012 on all patients undergoing surgery for low lacrimal obstruction at Dr. Luis Sanchez Bulnes Hospital, an Association for the prevention of blindness in Mexico IAP. Primary tumors of the lacrimal sac represented 2.5% of all lacrimal obstructions, being more common in women than in men (8:1). The large majority (89%) of the cases were non-epithelial, with lymphoid lesions being the most frequent. Benign tumors were presented at a younger age (50 years old) than malignant (70 years old). One-third (33%) of cases were unexpected findings during surgery (100% benign). Just over half (55%) were malignant tumors (1.4% of obstructions), all of them lymphoproliferative lesions. The most frequent clinical tumor was in the inner edge, either with or without epiphora. The progression time varied according to the degree of aggressiveness of the lymphoma (3 months-10 years). Lacrimal sac tumors are rare, but they must be taken into account in patients with an unusual clinical presentation of lacrimal obstruction. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

  14. Information Presentation

    Science.gov (United States)

    Holden, K.L.; Boyer, J.L.; Sandor, A.; Thompson, S.G.; McCann, R.S.; Begault, D.R.; Adelstein, B.D.; Beutter, B.R.; Stone, L.S.

    2009-01-01

    The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers at Johnson Space Center and Ames Research Center.

  15. Feasibility of OCT to detect radiation-induced esophageal damage in small animal models (Conference Presentation)

    Science.gov (United States)

    Jelvehgaran, Pouya; Alderliesten, Tanja; Salguero, Javier; Borst, Gerben; Song, Ji-Ying; van Leeuwen, Ton G.; de Boer, Johannes F.; de Bruin, Daniel M.; van Herk, Marcel B.

    2016-03-01

    Lung cancer survival is poor and radiotherapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to reduced food intake or even fistula formation. Only few direct techniques exist to measure radiation-induced esophageal damage, for which knowledge is needed to improve the balance between risk of tumor recurrence and complications. Optical coherence tomography (OCT) is a minimally-invasive imaging technique that obtains cross-sectional, high-resolution (1-10µm) images and is capable of scanning the esophageal wall up to 2-3mm depth. In this study we investigated the feasibility of OCT to detect esophageal radiation damage in mice. In total 30 mice were included in 4 study groups (1 main and 3 control groups). Mice underwent cone-beam CT imaging for initial setup assessment and dose planning followed by single-fraction dose delivery of 4, 10, 16, and 20Gy on 5mm spots, spaced 10mm apart. Mice were repeatedly imaged using OCT: pre-irradiation and up to 3 months post-irradiation. The control groups received either OCT only, irradiation only, or were sham-operated. We used histopathology as gold standard for radiation-induced damage diagnosis. The study showed edema in both the main and OCT-only groups. Furthermore, radiation-induced damage was primarily found in the highest dose region (distal esophagus). Based on the histopathology reports we were able to identify the radiation-induced damage in the OCT images as a change in tissue scattering related to the type of induced damage. This finding indicates the feasibility and thereby the potentially promising role of OCT in radiation-induced esophageal damage assessment.

  16. Construction of a radiometer for pyroelectric detector and presentation of a model for detector design

    International Nuclear Information System (INIS)

    Siqueira, C.A. de.

    1987-01-01

    An expression has been developed for the pyroelectric voltage as a function of electric and thermal parameters of the detector. It has also been developed expressions for determination of unknown parameters from the experimentally obtained pyroelectric voltage curve as function of time and some other known information. It has also been shown figures of merit for characterization of the detectors, a study showing the detector performance dependence on each electric and thermal parameter and some illustrative experimental results. The radiometer designed and built for this work, is described. (author) [pt

  17. Studies of Catalytic Model Systems

    DEFF Research Database (Denmark)

    Holse, Christian

    The overall topic of this thesis is within the field of catalysis, were model systems of different complexity have been studied utilizing a multipurpose Ultra High Vacuum chamber (UHV). The thesis falls in two different parts. First a simple model system in the form of a ruthenium single crystal...... of the Cu/ZnO nanoparticles is highly relevant to industrial methanol synthesis for which the direct interaction of Cu and ZnO nanocrystals synergistically boost the catalytic activity. The dynamical behavior of the nanoparticles under reducing and oxidizing environments were studied by means of ex situ X......-ray Photoelectron Electron Spectroscopy (XPS) and in situ Transmission Electron Microscopy (TEM). The surface composition of the nanoparticles changes reversibly as the nanoparticles exposed to cycles of high-pressure oxidation and reduction (200 mbar). Furthermore, the presence of metallic Zn is observed by XPS...

  18. Systemic rhabdomyosarcoma presenting as leukemia: case report with ultrastructural study and reviews.

    Science.gov (United States)

    Huntrakoon, M; Callaway, L A; Vergara, G G

    1987-08-01

    A 20-year-old white male was initially suspected clinically and pathologically of having an acute lymphoblastic leukemic process because of fatigue, severe anemia, thrombocytopenia, a leuko-erythroblastic peripheral blood picture, and a diffusely infiltrated bone marrow. Subsequent review of the bone marrow material indicated cytologic features consistent with either an embryonal, undifferentiated small cell mesenchymal malignancy or reticulo-endothelial malignancy. Ultimately, the electron microscopic (EM) study of the tumor proved to be diagnostic of rhabdomyosarcoma. An extensive search for a primary site of rhabdomyosarcoma did not show any lesion, although the genitourinary region was clinically suspected. The clinical course was a rapidly downhill one with extensive bone and CNS involvement. The patient died 5 months later. An autopsy permit was not obtained. This case emphasizes the occasional tendency of rhabdomyosarcoma to masquerade as a hematopoietic malignancy at the time of presentation and the usefulness of EM study in confirming a diagnosis.

  19. Uptake of external cephalic version for term breech presentation: an Australian population study, 2002-2012.

    Science.gov (United States)

    Bin, Yu Sun; Roberts, Christine L; Nicholl, Michael C; Ford, Jane B

    2017-07-26

    The safety, efficacy, and cost-effectiveness of external cephalic version (ECV) for term breech presentation has been demonstrated. Clinical guidelines recommend ECV for all eligible women, but the uptake of this procedure in the Australian healthcare setting is unknown. This study aimed to describe ECV uptake in New South Wales, the most populous state of Australia, during 2002 to 2012. Data from routine hospital and birth records were used to identify ECVs conducted at ≥36 weeks' gestation. Women with ECV were compared to women who were potentially eligible for but did not have ECV. Eligibility for ECV was based on clinical guidelines. For those with ECV, birth outcomes following successful and unsuccessful procedures were examined. In N = 32,321 singleton breech pregnancies, 10.5% had ECV, 22.3% were ineligible, and 67.2% were potentially eligible but did not undergo ECV. Compared to women who were eligible but who did not attempt ECV, those who had ECV were more likely to be older, multiparous, overseas-born, public patients at delivery, and to deliver in tertiary hospitals in urban areas (p < 0.01). Fewer women who underwent ECV smoked during pregnancy, fewer were morbidly obese, and fewer had a hypertensive disorder of pregnancy, compared to those who were eligible. Caesarean section occurred in 25.9% of successful compared to 95.6% of unsuccessful ECVs. Infant outcomes did not differ by ECV success. The majority of women with a breech presentation did not receive ECV. It is unclear whether this is attributable to issues with service provision or low acceptability among women. Policies to improve access to and information about ECV appear necessary to improve uptake among women with term breech presentation. Improved data collection around the diagnosis of breech presentation, ECV attempts, and outcomes may help to identify specific barriers to ECV uptake.

  20. Importance of the mooring system using in marine radioecology, present and planned studies in our country

    International Nuclear Information System (INIS)

    Kilic, O.; Belivermis, M.; Cotuk, Y.; Topcuoglu, S.

    2009-01-01

    Nowadays, the most important biomonitor organism is Mediterranean mussel species (Mytilus galloprovincialis) in handled monitoring studies in the marine radioecology content. This bio indicator species is also important both of the national and international monitoring programs. In this sense, Mediterranean and Black Sea mussel monitoring project was carried out with participating many countries which they have bank to Mediterranean and Black Sea by supported CIESM (Commission Internationale pour l'Expolaration Scientiphique de la mer Mediterranee) during the period of 2002-2004. All scientific data collected in a data bank. Furthermore, some new techniques were created for sampling and preparation of samples in monitoring of radionuclides and chemical pollutants by this project. On the other hand, the advantages of active bio monitoring compare to the passive bio monitoring were presented by discussed significance of mooring system.The mussel transplantation is carried out using of mooring systems for two goals. First one of them, available pollutants are to monitor in the absence of the mussel species in the stations by mussel transplantation in those stations. The other one of them, mussels which they are in same length and physiological state are to transplant the mooring systems and to monitor pollutants in mussel living and intended stations. In our country, the first mussel transplantation with established the mooring system was performed at the Oeluedeniz, Antalya, Tasucu, Botas and Arsuz stations. Active monitoring results of the works for radionuclide concentrations were given in this presented paper as well as passive monitoring findings were compared with the results obtained from Black Sea and Marmara Sea stations. Besides, it was presented the aim and content of mooring system that we planned to establish in the Golden Horn in this presentation.

  1. Clinical presentation of soft-tissue infections and its management: A study of 100 cases

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    Baldev Singh

    2017-01-01

    Full Text Available Background: Soft-tissue infections vary widely in their nature and severity. A clear approach to the management must allow their rapid identification and treatment as they can be life-threatening. Objective: Clinical presentation of soft-tissue infections and its management. Materials and Methods: A prospective study based on 100 patients presenting with soft-tissue infections was done. All the cases of soft-tissue infections were considered irrespective of age, sex, etiological factors, or systemic disorders. The findings were evaluated regarding the pattern of soft-tissue infections in relation to age and sex, clinical presentation, complications, duration of hospital stay, management, and mortality. Results: The most commonly involved age group was in the range of 41–60 years with male predominance. Abscess formation (45% was the most common clinical presentation. Type 2 diabetes mellitus was the most common associated comorbid condition. Staphylococcus aureus was the most common culture isolate obtained. The most common complication seen was renal failure. Patients with surgical site infections had maximum duration of stay in the hospital. About 94% of the cases of soft-tissue infections were managed surgically. Mortality was mostly encountered in the cases of complications of cellulitis. Conclusion: Skin and soft-tissue infections are among the most common infections encountered by the emergency physicians. Ignorance, reluctance to treatment, economic constraints, and illiteracy delay the early detection and the initiation of proper treatment. Adequate and timely surgical intervention in most of the cases is of utmost importance to prevent the complications and reduce the mortality.

  2. Climate Past and Present: A Study on Glaciology of Himalayas in India

    Science.gov (United States)

    Shanmuganandan, S.

    2003-04-01

    Glaciers are moving bodies of ice and snow, which are normally present above the snow line. Glaciers and ice sheets are hundreds to more than one thousand meters thick and change significantly only over decades. On these longer time scales they can influence atmospheric circulation and global sea levels. Glaciers play an important role in maintaining ecosystem stability as they act as buffers and regulate the runoff water supply from high mountains to the plains during both dry and wet spells. The present study is an attempt to analyze the Climate of the Past and Present of the Himalayas with reference to study the glaciology. The study also attempted to use the remote sensed data to explore the past and present situation of glaciology of the Himalayas. Since mountain glaciology of Himalayas played a vital role and stand as an example to explore the possibility of the climate change that occurred from the past to the present and also to determine the status in the future. The Study was based on the secondary and primary data collected from available sources and also collected from various published records to document the evidences for the same. It was observed that the Himalayan glaciers account for about 70% of the world’s non-polar glaciers and affect the lives of millions of people in several countries: China, India, Pakistan, Afghanistan, Nepal and Bangladesh. Their runoff feeds two of the oldest rivers in the world, the Indus and the Ganges, whose tributaries carry precious water for 500 million people on the northern Indian plains. Most of the glaciers in the Himalayas are of a summer-accumulation type, that is major accumulation and ablation take place simultaneously during summer (Fujita et. al, 1997). The glaciers of the Himalayas include some of the longest outside the Polar Regions and reached their largest extent during the end of the last ice age (more than 20,000 years ago). The evidence of these large ice masses can be seen in 'U' shaped valleys

  3. Descriptive analysis of context evaluation instrument for technical oral presentation skills evaluation: A case study in English technical communication course

    Science.gov (United States)

    Mohamed, Abdullah-Adnan; Asmawi, Adelina; Hamid, Mohd Rashid Ab; Mustafa, Zainol bin

    2015-02-01

    This paper reports a pilot study of Context Evaluation using a self-developed questionnaire distributed among engineering undergraduates at a university under study. The study aims to validate the self-developed questionnaires used in the Context evaluation, a component in the CIPP Model. The Context evaluation assesses background information for needs, assets, problems and opportunities relevant to beneficiaries of the study in a defined environment. Through the questionnaire, background information for the assessment of needs, assets and problems related to the engineering undergraduates' perceptions on the teaching and learning of technical oral presentation skills was collected and analysed. The questionnaire was developed using 5-points Likert scale to measure the constructs under study. They were distributed to 100 respondents with 79 returned. The respondents consisted of engineering undergraduates studied at various faculties at one technical university in Malaysia. The descriptive analysis of data for each item which makes up the construct for Context evaluation is found to be high. This implied that engineering undergraduates showed high interest in teaching and learning of technical oral presentation skills, thus their needs are met. Also, they agreed that assets and facilities are conducive to their learning. In conclusion, the context evaluation involving needs and assets factors are both considerably important; their needs are met and the assets and facilities do support their technical oral presentation skills learning experience.

  4. Late-presenting developmental dysplasia of the hip in Jordanian males. A retrospective hospital based study

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    Omar Q. Samarah

    2016-02-01

    Full Text Available Objectives: To describe the pattern of developmental dysplasia of the hip (DDH in late presenting Jordanian male patients and identify the risk factors and associated findings. Methods: This is a retrospective study of 1145 male patients who attended the Pediatric Orthopedic Clinic for a DDH check up. This study was carried out in the Orthopedic Section, Special Surgery Department, Faculty of Medicine, The University of Jordan, Amman, Jordan between March 2011 and October 2014. Data was collected from medical records, and x-ray measurements were evaluated. Results: Of the 1145 male patients, 43 (3.75% with 70 involved hips were diagnosed with late- presenting DDH. Being a first-born baby resulted in 41.9% increased risk for DDH. Cesarian delivery was significantly associated with an increased risk of hip dislocation (p=0.004 while normal delivery was significantly associated with acetabular dysplasia (p=0.004. No predictable risk factors were found in 44.2% patients with DDH. Bilateral cases were more common than unilateral cases: (26 [60.5%] versus 17 [39.5%]. Limited abduction was a constant finding in all dislocated hips (p less than 0.001. Associated conditions, such as club foot and congenital muscular torticollis were not observed. Conclusion: Cesarian section is a significant risk for dislocated hips while normal delivery is significantly associated with acetabular dysplasia. Bilateral DDH is more common than the unilateral. Club foot and torticollis were not observed in this series.

  5. Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin

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    Franco Cavaleri

    2018-01-01

    Full Text Available Various parts of the turmeric plant have been used as medicinal treatment for various conditions from ulcers and arthritis to cardiovascular disease and neuroinflammation. The rhizome’s curcumin extract is the most studied active constituent, which exhibits an expansive polypharmacology with influence on many key inflammatory markers. Despite the expansive reports of curcucmin’s therapeutic value, clinical reliability and research repeatability with curcumin treatment are still poor. The pharmacology must be better understood and reliably mapped if curcumin is to be accepted and used in modern medical applications. Although the polypharmacology of this extract has been considered, in mainstream medicine, to be a drawback, a perspective change reveals a comprehensive and even synergistic shaping of the NF-kB pathway, including transactivation. Much of the inconsistent research data and unreliable clinical outcomes may be due to a lack of standardization which also pervades research standard samples. The possibility of other well-known curcumin by-products contributing in the polypharmacology is also discussed. A new flowchart of crosstalk in transduction pathways that lead to shaping of nuclear NF-kB transactivation is generated and a new calibration or standardization protocol for the extract is proposed which could lead to more consistent data extraction and improved reliability in therapy.

  6. Isotope tracers in global water and climate studies of the past and present

    International Nuclear Information System (INIS)

    Edwards, T.W.D.; Birks, S.J.; Gibson, J.J.

    2002-01-01

    To date the global distribution of isotopes in modern precipitation has been characterized almost exclusively from the IAEA/WMO GNIP database, although patchiness of GNIP station records in both time and space has limited the potential of isotope hydrology and climate applications in some areas. Herein, we discuss the prospect of utilizing GCMs for simulating global isotope distributions as a supplementary tool for modern and paleoclimate isotope studies to bridge this gap. Such models currently generate reliable zonal isotope fields, and it is anticipated that future enhancements in finescale resolution of GCMs, and incorporation of land-surface feedbacks and topography will allow for future development of a global reanalysis data set ground-truthed by GNIP. Compilation of time-slice maps of past isotope distribution in precipitation from archival records of meteoric waters also offers significant potential to ground-truth paleoclimate simulations extending back tens to hundreds of thousands of years. (author)

  7. Present Food Shopping Habits in the Spanish Adult Population: A Cross-Sectional Study

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    María Achón

    2017-05-01

    Full Text Available Information on grocery shopping patterns is one key to understanding dietary changes in recent years in Spain. This report presents an overview of Spanish food shopping patterns in the adult population. A cross-sectional, nationally representative telephone survey was conducted in Spain. Individuals were asked about food shopping responsibility roles, types of visited food stores, time spent, additional behaviors while shopping, the influence of marketing/advertising and, in particular, fresh produce shopping profile. Binary logistic regression models were developed. The final random sample included 2026 respondents aged ≥18 years, of which 1223 were women and 803 were men. Women reported being in charge of most of the food shopping activities. Looking for best prices, more than looking for healthy or sustainable foods, seemed to be a general behavior. Supermarkets were the preferred retail spaces for food price consideration, convenience, variety and availability. Fresh produce shopping was associated with traditional markets and neighborhood stores in terms of reliance and personalized service. It is essential to highlight the importance of the role played by women. They are the main supporters concerned in preserving adequate dietary habits. Economic factors, more than health or food sustainability, are commonly considered by the population. Traditional markets may play an important role in preserving some healthy dietary habits of the Mediterranean food culture in Spain.

  8. Present Food Shopping Habits in the Spanish Adult Population: A Cross-Sectional Study.

    Science.gov (United States)

    Achón, María; Serrano, María; García-González, Ángela; Alonso-Aperte, Elena; Varela-Moreiras, Gregorio

    2017-05-18

    Information on grocery shopping patterns is one key to understanding dietary changes in recent years in Spain. This report presents an overview of Spanish food shopping patterns in the adult population. A cross-sectional, nationally representative telephone survey was conducted in Spain. Individuals were asked about food shopping responsibility roles, types of visited food stores, time spent, additional behaviors while shopping, the influence of marketing/advertising and, in particular, fresh produce shopping profile. Binary logistic regression models were developed. The final random sample included 2026 respondents aged ≥18 years, of which 1223 were women and 803 were men. Women reported being in charge of most of the food shopping activities. Looking for best prices, more than looking for healthy or sustainable foods, seemed to be a general behavior. Supermarkets were the preferred retail spaces for food price consideration, convenience, variety and availability. Fresh produce shopping was associated with traditional markets and neighborhood stores in terms of reliance and personalized service. It is essential to highlight the importance of the role played by women. They are the main supporters concerned in preserving adequate dietary habits. Economic factors, more than health or food sustainability, are commonly considered by the population. Traditional markets may play an important role in preserving some healthy dietary habits of the Mediterranean food culture in Spain.

  9. Modelling the economic losses of historic and present-day high-impact winter storms in Switzerland

    Science.gov (United States)

    Welker, Christoph; Stucki, Peter; Bresch, David; Dierer, Silke; Martius, Olivia; Brönnimann, Stefan

    2014-05-01

    Severe winter storms such as "Vivian" in February 1990 and "Lothar" in December 1999 are among the most destructive meteorological hazards in Switzerland. Disaster severity resulting from such windstorms is attributable, on the one hand, to hazardous weather conditions such as high wind gust speeds; and on the other hand to socio-economic factors such as population density, distribution of values at risk, and damage susceptibility. For present-day winter storms, the data basis is generally good to describe the meteorological development and wind forces as well as the associated socio-economic impacts. In contrast, the information on historic windstorms is overall sparse and the available historic weather and loss reports mostly do not provide quantitative information. This study illustrates a promising technique to simulate the economic impacts of both historic and present winter storms in Switzerland since end of the 19th century. Our approach makes use of the novel Twentieth Century Reanalysis (20CR) spanning 1871-present. The 2-degree spatial resolution of the global 20CR dataset is relatively coarse. Thus, the complex orography of Switzerland is not realistically represented, which has considerable ramifications for the representation of wind systems that are strongly influenced by the local orography, such as Föhn winds. Therefore, a dynamical downscaling of the 20CR to 3 km resolution using the Weather Research and Forecasting (WRF) model was performed, for in total 40 high-impact winter storms in Switzerland since 1871. Based on the downscaled wind gust speeds and the climada loss model, the estimated economic losses were calculated at municipality level for current economic and social conditions. With this approach, we find an answer to the question what would be the economic losses of e.g. a hazardous Föhn storm - which occurred in northern Switzerland in February 1925 - today, i.e. under current socio-economic conditions. Encouragingly, the pattern of

  10. Evaluation of coronary features of HIV patients presenting with ACS: The CUORE, a multicenter study.

    Science.gov (United States)

    Peyracchia, Mattia; De Lio, Giulia; Montrucchio, Chiara; Omedè, Pierluigi; d'Ettore, Gabriella; Calcagno, Andrea; Vullo, Vincenzo; Cerrato, Enrico; Pennacchi, Mauro; Sardella, Gennaro; Manga, Pravin; GrossoMarra, Walter; Vullo, Francesco; Fedele, Francesco; Biondi-Zoccai, Giuseppe; Moretti, Claudio; Vachiat, Ahmed; Bonora, Stefano; Rinaldi, Mauro; Mancone, Massimo; D'Ascenzo, Fabrizio

    2018-05-05

    The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. In this multicenter case-control study, HIV patients presenting with ACS, with intravascular-ultrasound (IVUS) data, enrolled between February 2015 and June 2017, and undergoing highly active antiretroviral therapy (HAART), were retrospectively compared to non-HIV patients presenting with ACS, before and after propensity score with matching, randomly selected from included centers. Primary end-point was the prevalence of multivessel disease. Secondary end-points were the prevalence of abnormal features at IVUS, the incidence of major-acute-cardiovascular-events (MACE), a composite end point of cardiovascular death, MI, target lesion revascularization (TLR), stent thrombosis (ST), non-cardiac death and target vessel revascularization (TVR). For each end-point, a subgroup analysis was conducted in HIV patients with CD4 cell count <200/mm 3 . Before propensity score, 66 HIV patients and 120 non-HIV patients were selected, resulting in 20 and 40 after propensity score. Patients with multivessel disease were 11 and 17, respectively (p = 0.56). IVUS showed a lower plaque burden (71% vs. 75%, p < 0.001) and a higher prevalence of hyperechoic non-calcified plaques (100% vs. 35%, p < 0.05) in HIV patients; a higher prevalence of hypoechoic plaques (7% vs. 0%, p < 0.05), a higher incidence of MACE (17.4% vs. 9.1% vs. l'8.0%, p < 0.05), MI recurrence (17.2% vs. 0.0% vs. 2.3%, p < 0.05), and ST (6.7% vs. 0.3% vs. 03%, p < 0.05) in HIV patients with CD4 < 200/mm 3 . Our study may provide a part of the pathophysiological basis of the differences in coronary arteries between HIV-positive and HIV-negative patients, suggesting that the former present with peculiar morphological features at IVUS, even after adjustment for clinical variables

  11. A STUDY OF THE OCULAR MANIFESTATIONS OF RHEUMATOID ARTHRITIS AMONG PATIENTS PRESENTING TO A TERTIARY CENTRE

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    Dhanya Sukumaran

    2017-08-01

    Full Text Available BACKGROUND Rheumatoid Arthritis (RA is a chronic inflammatory disease of unknown aetiology marked by a symmetric peripheral polyarthritis. It is the most common form of chronic inflammatory arthritis and often results in joint damage and physical disability. The name is based on the term "rheumatic fever", an illness, which includes joint pain and is derived from the Greekword ῥεύμα-rheuma (nom., ῥεύματος-rheumatos (gen. ("flow, current". The suffix oid ("resembling" gives the translation as joint inflammation that resembles rheumatic fever. The first recognised description of rheumatoid arthritis was made in 1800 by Dr. Augustin Jacob Landré-Beauvais (1772-1840 of Paris. Because, it is a systemic disease, RA may result in a variety of extra-articular manifestations including fatigue, subcutaneous nodules, lung involvement, pericarditis, peripheral neuropathy, vasculitis and haematologic abnormalities. MATERIALS AND METHODS Patients who were diagnosed cases of rheumatoid arthritis attending the rheumatology clinic were referred to the Ophthalmology OPD in Government Medical College, Thrissur, for detailed eye examination. RESULTS The study was conducted in 100 patients (88 females and 12 males. Rheumatoid Factor (RF was found to be positive in 60 patients (60%, presence of dry eye did not correlate with rheumatoid positivity (Fishers exact test- the two-tailed P value = 0.4256. Through various tests, we concluded that there was aqueous deficiency in 61% and mucin deficiency in 46% of the patients. Other ocular manifestations present were- scleritis (2%, episcleritis (2% and keratomalacia (2%. CONCLUSION From the present study, we found out that extra-articular involvement of organs in rheumatoid arthritis is significant. The main ocular manifestations in rheumatoid arthritis found in our study were keratoconjunctivitis sicca, episcleritis, scleritis and keratomalacia. Though keratoconjunctivitis sicca was the most common, it did

  12. Study to Evaluate Targeted Management and Syndromic Management in Women Presenting with Abnormal Vaginal Discharge.

    Science.gov (United States)

    Meena, Veena; Bansal, Charu Lata

    2016-10-01

    Vaginal discharge is a commonest complaint among women in reproductive age group. Infective vaginal discharge can be broadly categorized into vaginitis or mucopurulent cervicitis. Vaginitis is predominantly caused by bacterial vaginosis, vaginal candidiasis, vaginal trichomoniasis, etc. Mucopurulent cervicitis is due to chlamydia or gonococcal infection. The targeted management is based on identification of causative organism and targeting the therapy against it, while syndromic management is based on high risk factors's presence. To study the effect of targeted management as compared to syndromic management in achieving a complete cure for abnormal vaginal discharge and to study the microbial flora of women presenting with abnormal vaginal discharge. The study is a randomized control trial conducted at tertiary health care on 200 women who presented with abnormal vaginal discharge, distributed in two groups A and B each consisted of 100 women. Group A underwent laboratory investigations, and treatment was started as soon as reports were available. Group B was given syndromic management based on high risk factors's presence. Both groups were followed up after 2 weeks. The prevalence of various organisms in vaginal discharge was candidiasis 39 %, bacterial vaginosis 28 %, trichomoniasis 5 %, N. gonorrhoeae 5 % and chlamydia 2 % among the 100 women in group A. Response to treatment for vaginitis was 76.3 % in group A, whereas it was 41 % in group B. With cervicitis, 71.4 % women responded to treatment in targeted group as compared to 54 % in syndromic management group. There is a potential disadvantage of syndromic management because of its total reliability on a subjective clinical assessment.

  13. Diabetes Is Associated with Worse Clinical Presentation in Tuberculosis Patients from Brazil: A Retrospective Cohort Study.

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    Leonardo Gil-Santana

    Full Text Available The rising prevalence of diabetes mellitus (DM worldwide, especially in developing countries, and the persistence of tuberculosis (TB as a major public health issue in these same regions, emphasize the importance of investigating this association. Here, we compared the clinical profile and disease outcomes of TB patients with or without coincident DM in a TB reference center in Brazil.We performed a retrospective analysis of a TB patient cohort (treatment naïve of 408 individuals recruited at a TB primary care center in Brazil between 2004 and 2010. Data on diagnosis of TB and DM were used to define the groups. The study groups were compared with regard to TB disease presentation at diagnosis as well as to clinical outcomes such as cure and mortality rates upon anti-tuberculosis therapy (ATT initiation. A composite score utilizing clinical, radiological and microbiological parameters was used to compare TB severity between the groups.DM patients were older than non-diabetic TB patients. In addition, diabetic individuals more frequently presented with cough, night sweats, hemoptysis and malaise than those without DM. The overall pattern of lung lesions assessed by chest radiographic examination was similar between the groups. Compared to non-diabetic patients, those with TB-diabetes exhibited positive acid-fast bacilli in sputum samples more frequently at diagnosis and at 30 days after ATT initiation. Notably, higher values of the TB severity score were significantly associated with TB-diabetes comorbidity after adjustment for confounding factors. Moreover, during ATT, diabetic patients required more frequent transfers to TB reference hospitals for complex clinical management. Nevertheless, overall mortality and cure rates were indistinguishable between the study groups.These findings reinforce the idea that diabetes negatively impacts pulmonary TB severity. Our study argues for the systematic screening for DM in TB reference centers in endemic

  14. Pitting corrosion of copper. Further model studies

    International Nuclear Information System (INIS)

    Taxen, C.

    2002-08-01

    The work presented in this report is a continuation and expansion of a previous study. The aim of the work is to provide background information about pitting corrosion of copper for a safety analysis of copper canisters for final deposition of radioactive waste. A mathematical model for the propagation of corrosion pits is used to estimate the conditions required for stationary propagation of a localised anodic corrosion process. The model uses equilibrium data for copper and its corrosion products and parameters for the aqueous mass transport of dissolved species. In the present work we have, in the model, used a more extensive set of aqueous and solid compounds and equilibrium data from a different source. The potential dependence of pitting in waters with different compositions is studied in greater detail. More waters have been studied and single parameter variations in the composition of the water have been studied over wider ranges of concentration. The conclusions drawn in the previous study are not contradicted by the present results. However, the combined effect of potential and water composition on the possibility of pitting corrosion is more complex than was realised. In the previous study we found what seemed to be a continuous aggravation of a pitting situation by increasing potentials. The present results indicate that pitting corrosion can take place only over a certain potential range and that there is an upper potential limit for pitting as well as a lower. A sensitivity analysis indicates that the model gives meaningful predictions of the minimum pitting potential also when relatively large errors in the input parameters are allowed for

  15. A STUDY OF THE VARIED AETIOLOGY AND CLINICAL PRESENTATION OF NEW ONSET SEIZURES IN POSTPARTUM PERIOD

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    Ravindra Kumar Sudarsi

    2016-08-01

    Full Text Available BACKGROUND Seizures in the postpartum period are the major cause of mortality and morbidity. A variety of neurological disorders causing seizures may be encountered during pregnancy and puerperium. These disorders may be unrelated to pregnancy (e.g. Meningitis or peculiar to pregnancy (e.g. Eclampsia or. Pregnancy may affect the course of the pre-existing neurological disorders such as epilepsy. So, keeping in mind the varied aetiology of postpartum seizures and its response to appropriate treatment, our study has been conducted to find out the most common causes in our setup to guide the optimal therapy. AIM OF THE STUDY To study the varied aetiology and clinical presentation of new onset seizures in the postpartum period over a period of two years. MATERIALS AND METHODS 50 patients who developed first episode of seizures in postpartum period (that is after delivery to 6 weeks admitted to Osmania General Hospital on random selection. All women complaining of new onset seizure with in postpartum period up to 6 weeks. All those women who are known epileptics and who had seizures in the antenatal period were excluded from the study. The selected patients were studied in detail with history and physical examination. RESULTS Different causes for first episode of seizures in postpartum period are enlisted here. Cavernous sinus thrombosis in 17 patients, late postpartum eclampsia accounted for 13 patients, intracranial haemorrhage in 6 patients, ischaemic stroke in 5 patients, posterior reversible encephalopathy syndrome in 4 patients, CNS infections in 6 patients, glioma in 1 patient, viral hepatitis in one patient, idiopathic in 3 patients. CONCLUSIONS Cavernous sinus thrombosis and late postpartum eclampsia constitute the major aetiology of first onset of seizes occurring in the postpartum period.

  16. A Fundamental Study on Influence of Concurrently Presented Visual Stimulus Upon Loudness Perception

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    Koji Abe

    2011-10-01

    Full Text Available As a basic study on the influence of the dynamic properties of the audio-visual stimuli upon interaction between audition and vision, the effect of the simple movement involved in the visual stimulus on the loudness perception of the audio stimulus was investigated via psychophysical experiment. In this experiment, the visual stimulus given to subjects along with the audio stimulus is a bar appeared on a display, one side of which is flexibly expanding and contracting. The loudness of the audio stimulus with such a visual effect concurrently presented was rated as an absolute numerical value by using the Magnitude Estimation method. The reference of the bar length is determined so as to correspond to the Zwicker's loudness calculated for the given audio stimulus. As a result, the visual stimulus did not affect the loudness perception, when the bar was presented with its length same as the reference. On the other hand, the rating of the loudness for the same audio stimulus was significantly increased when the bar length was longer than the reference. This indicates that the change in the correspondence between the audio and the visual stimuli affect the loudness perception.

  17. Canine dilated cardiomyopathy: a retrospective study of signalment, presentation and clinical findings in 369 cases.

    Science.gov (United States)

    Martin, M W S; Stafford Johnson, M J; Celona, B

    2009-01-01

    To review the clinical and diagnostic findings and survival of dilated cardiomyopathy from a large population of dogs in England. A retrospective study of the case records of dogs with dilated cardiomyopathy collected between January 1993 and May 2006. There were 369 dogs with dilated cardiomyopathy of which all were pure-bred dogs except for four. The most commonly affected breeds were dobermanns and boxers. Over 95 per cent of dogs weighed more than 15 kg and 73 per cent were male. The median duration of signs before referral was three weeks with 65 per cent presenting in stage 3 heart failure. The most common signs were breathlessness (67 per cent) and coughing (64 per cent). The majority of dogs (89 per cent) had an arrhythmia at presentation and 74 per cent of dogs had radiographic signs of pulmonary oedema or pleural effusion. The median survival time was 19 weeks. Dilated cardiomyopathy occurs primarily in medium to large breed pure-bred dogs, and males are more frequently affected than females. The duration of clinical signs before referral is often short and the survival times are poor. Greater awareness of affected breeds, clinical signs and diagnostic findings may help in early recognition of this disease which often has a short clinical phase.

  18. Performance of the present ALICE Inner Tracking System and studies for the upgrade

    International Nuclear Information System (INIS)

    Contin, G

    2012-01-01

    The Inner Tracking System (ITS) of the ALICE experiment is made out of six layers of silicon detectors exploiting three different technologies (pixel, drift and strip). It covers the central pseudorapidity range of |η| < 0.9 and its distance from the beam line ranges from r = 3.9 cm for the innermost pixel layer up to r = 43 cm for the outermost strip layer. The main tasks of the ITS are to reconstruct the primary and secondary vertices, to track and identify charged particles with a low pt cutoff and to improve the momentum resolution at high pt. In this talk I will present the performance of the ITS in p-p and Pb-Pb collisions in 2010, both from the hardware point of view, with a brief overview of the features of the system, and the physics achievements for what concerns the vertexing, the tracking and the particle identification. Furthermore, I will give also an outlook on a possible upgrade of the ALICE ITS which is presently being studied, in order to extend its physics performance by improving the measurements of charmed hadrons and accessing new physics items like the measurement of the beauty hadrons.

  19. A pilot study: research poster presentations as an educational tool for undergraduate epidemiology students

    Directory of Open Access Journals (Sweden)

    Deonandan R

    2013-09-01

    Full Text Available Raywat Deonandan, James Gomes, Eric Lavigne, Thy Dinh, Robert Blanchard Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada Abstract: Students in a fourth year epidemiology course were surveyed after participating in a formal Science Research Day in which they presented original research, in poster form, to be judged by scientists from the community. Of 276 participating students, 80 (29% responded to the study survey. As a result, 19% of respondents were more likely to pursue a career in science, and 27.5% were more likely to pursue a career in epidemiology. Only one respondent reported being less likely to pursue a science career, while seven were less likely to pursue epidemiology. A majority of respondents felt that the poster experience was on par with, or superior to, a comparable research paper, in terms of both educational appeal and enjoyment. Mandatory, formal poster presentations are an innovative format for teaching advanced health sciences, and may more accurately reflect the realities of a science career than do more traditional educational formats. Keywords: epidemiology, education, undergraduate, research–teaching nexus

  20. Factors affecting presentation and delay in patients with testicular cancer: results of a qualitative study.

    Science.gov (United States)

    Gascoigne, P; Mason, M D; Roberts, E

    1999-01-01

    A qualitative study was undertaken with men treated for testicular tumours, to ascertain how they interpreted their symptoms and the factors which influenced a decision to consult a physician. The research was undertaken with six men who had been diagnosed as having testicular tumours. Interviews were also conducted with four wives and one mother. The findings showed that giving men information on testicular cancer may not guarantee early presentation. Symptoms were not generally attributed to cancer and the one patient who practised self-examination had delayed seeking help for 6 months. The extent to which symptoms affected the patient's lifestyle was also a factor in the decision-making process, as was the checking of symptoms with other family members. Wives were often pivotal in persuading men to seek help. The discovery of testicular symptoms produced emotional responses which included embarrassment and fear of both cancer and castration. There was evidence of strong feelings of masculine identity bound up with the appearance of 'normal' genitals. Provider-delay was identified in four cases and was associated with misattribution of symptoms by physicians and the failure to initiate specialist referral. Delay was under-recorded in the hospital notes in all cases where presentation was not immediate.

  1. Ultrasound study of scrotal pathology presenting as acute scrotal pain in the emergency room setting

    International Nuclear Information System (INIS)

    Lozano, C.; Serrano, C.; Revilla, Y.; Miralles, M.; Pozo, G. del; Lopez, U.

    1998-01-01

    The purpose of this reports is to review the most significant ultrasonographic features of the clinical entries that most frequently present as acute scrotal pain in childhood. We review 145 cases of acute scrotal referred by the emergency unit to the Radiology Service over a four-year period (1992-1995). All the patients were studied by B-mode ultrasound and the great majority also underwent color duplex-Doppler ultrasound. A wide variety of diseases were recorded, comprised of epididymitis (n=38), epididymo-orchitis (n=24), hydrocele (n=26), testicular torsion (n=9), cord cyst (n=9), epididymal cyst (n=7), persisting peritoneal-vagina fistula (n=6), hydatid torsion (n=4), sheath hematoma (n=4), laceration (n=4), hematocele (n=3), varicocele (n=3), epididymal hematoma (n=2), testicular hematoma (n=2), tumor (n=2) and inguinoscrotal hernia (n=2). (Author) 20 refs

  2. Characteristics of patients with rheumatoid arthritis presenting for physiotherapy management: a multicentre study.

    Science.gov (United States)

    Kennedy, Norelee; Keogan, Fiona; Fitzpatrick, Martina; Cussen, Grainne; Wallace, Lorraine

    2007-03-01

    To describe the characteristics of patients with rheumatoid arthritis (RA) attending for physiotherapy management in Ireland. Managers of physiotherapy departments in the 53 hospitals in Ireland were invited to participate in a multi-centre observational study over a 6-month period. Data on patients with RA the day of presentation for physiotherapy management were recorded. These data related to patient demographic details, disease management, aids and appliances, splint and orthoses usage and occupational issues. The Health Assessment Questionnaire was also recorded for each patient. A total of 273 patients from eight physiotherapy departments participated in the survey (n = 199; 73% female). Mean age of the participants was 59.3 (SD 12.5) years with mean disease duration of 13.8 (SD 10.6) years. The majority of the patients were inpatients (n = 170, 62%). Sixty-eight per cent of patients had attended for previous physiotherapy treatment and 98% were under current rheumatologist care. Biologic therapies were prescribed to 11% of patients. Use of splint and foot orthoses was high with 133 patients (49%) wearing splints and 75 (31%) wearing foot orthoses. The majority of patients had moderate (n = 119, 44%) or severe (n = 94, 35%) disability as per Health Assessment Questionnaire (HAQ) score. Mean HAQ score was 1.5, with HAQ scores showing increasing disability with increasing age, disease duration and erythrocyte sedimentation rate (ESR) levels. Patients with RA attending for physiotherapy management present with varied profiles. This study provides valuable information on the characteristics of patients with RA attending for physiotherapy management which will contribute to physiotherapy service planning and delivery and will optimize patient care.

  3. Analysis of acute ischemic stroke presenting classic lacunar syndrome. A study by diffusion-weighted MRI

    Energy Technology Data Exchange (ETDEWEB)

    Terai, Satoshi; Ota, Kazuki; Tamaki, Kinya [Hakujyuji Hospital, Fukuoka (Japan)

    2002-03-01

    We retrospectively assessed the pathophysiological features of acute ischemic stroke presenting ''classic'' lacunar syndrome by using diffusion-weighted imaging (DWI). Subjects were 16 patients who were admitted to our hospital within 24 hours of stroke onset and underwent DWI examination on admission. These were divided into three categorical groups; pure motor hemiplegia (PMH) in 8, sensorimotor stroke (SMS) in 7, and dysarthria-clumsy hand syndrome (DCHS) in 1. The fresh responsible lesions were identified by DWI in the perforating territory in 7 patients with PMH and 7 with SMS. Four (one had two possible response lesions; pons and corona radiata) and five patients in the respective groups were diagnosed as lacunar infarction on admission (the largest dimension of the lesion measuring smaller than 15 mm). On the contralateral side to the neurological symptoms, DWI revealed high intensities in cortex, subcortical white matter, and anterior and posterior border zones in the remaining one patient with PMH and in the precentral arterial region in one with DCHS. They were diagnosed as atherothrombotic infarction resulting from the occlusion of the internal carotid artery and cerebral embolism due to atrial fibrillation, respectively. Three patients with PMH showed progressive deterioration after admission and follow-up DWI study in an acute stage revealed enlargement of heir ischemic lesions. The present study suggests that DWI is a useful imaging technique for diagnosis of clinical categories and observation for pathophsiological alteration in the acute ischemic stroke patients with ''classic'' lacunar syndrome. Our results also indicate a necessity to be aware that various types of fresh ischemic lesions other than a single lacune might possibly be developing in cases with this syndrome. (author)

  4. Evaluation of biases present in the cohort multiple randomised controlled trial design: a simulation study

    Directory of Open Access Journals (Sweden)

    Jane Candlish

    2017-01-01

    Full Text Available Abstract Background The cohort multiple randomised controlled trial (cmRCT design provides an opportunity to incorporate the benefits of randomisation within clinical practice; thus reducing costs, integrating electronic healthcare records, and improving external validity. This study aims to address a key concern of the cmRCT design: refusal to treatment is only present in the intervention arm, and this may lead to bias and reduce statistical power. Methods We used simulation studies to assess the effect of this refusal, both random and related to event risk, on bias of the effect estimator and statistical power. A series of simulations were undertaken that represent a cmRCT trial with time-to-event endpoint. Intention-to-treat (ITT, per protocol (PP, and instrumental variable (IV analysis methods, two stage predictor substitution and two stage residual inclusion, were compared for various refusal scenarios. Results We found the IV methods provide a less biased estimator for the causal effect when refusal is present in the intervention arm, with the two stage residual inclusion method performing best with regards to minimum bias and sufficient power. We demonstrate that sample sizes should be adapted based on expected and actual refusal rates in order to be sufficiently powered for IV analysis. Conclusion We recommend running both an IV and ITT analyses in an individually randomised cmRCT as it is expected that the effect size of interest, or the effect we would observe in clinical practice, would lie somewhere between that estimated with ITT and IV analyses. The optimum (in terms of bias and power instrumental variable method was the two stage residual inclusion method. We recommend using adaptive power calculations, updating them as refusal rates are collected in the trial recruitment phase in order to be sufficiently powered for IV analysis.

  5. Study of resonant processes in plasmonic nanostructures for sensor applications (Conference Presentation)

    Science.gov (United States)

    Pirunčík, Jiří; Kwiecien, Pavel; Fiala, Jan; Richter, Ivan

    2017-05-01

    This contribution is focused on the numerical studies of resonant processes in individual plasmonic nanostructures, with the attention particularly given to rectangular nanoparticles and concominant localized surface plasmon resonance processes. Relevant models for the description and anylysis of localized surface plasmon resonance are introduced, in particular: quasistatic approximation, Mie theory and in particular, a generalized (quasi)analytical approach for treating rectangularly shaped nanostructures. The parameters influencing resonant behavior of nanoparticles are analyzed with special interest in morphology and sensor applications. Results acquired with Lumerical FDTD Solutions software, using finite-difference time-domain simulation method, are shown and discussed. Simulations were mostly performed for selected nanostructures composed of finite rectangular nanowires with square cross-sections. Systematic analysis is made for single nanowires with varying length, parallel couple of nanowires with varying gap (cut -wires) and selected dolmen structures with varying gap between one nanowire transversely located with respect to parallel couple of nanowires (in both in-plane and -out-of-plane arrangements). The dependence of resonant peaks of cross-section spectral behavior (absorption, scattering, extinction) and their tunability via suitable structuring and morphology changes are primarily researched. These studies are then followed with an analysis of the effect of periodic arrangements. The results can be usable with respect to possible sensor applications.

  6. Type 2 diabetes genes – Present status and data from Norwegian studies

    Directory of Open Access Journals (Sweden)

    Jens K. Hertel Hertel

    2013-06-01

    Full Text Available The worldwide rise in prevalence of type 2 diabetes has led to an intense search for the genetic risk factors of this disease. In type 2 diabetes and other complex disorders, multiple genetic and environmental factors, as well as the interaction between these factors, determine the phenotype. In this review, we summarize present knowledge, generated by more than two decades of efforts to dissect the genetic architecture of type 2 diabetes. Initial studies were either based on a candidate gene approach or attempted to fine-map signals generated from linkage analysis. Despite the detection of multiple genomic regions proposed to be linked to type 2 diabetes, subsequent positional fine-mapping of candidates were mostly inconclusive. However, the introduction of genome-wide association studies (GWAS, applied on thousands of patients and controls, completely changed the field. To date, more than 50 susceptibility loci for type 2 diabetes have been detected through the establishment of large research consortia, the application of GWAS on intermediary diabetes phenotypes and the use of study samples of different ethnicities. Still, the common variants identified in the GWAS era only explain some of the heritability seen for type 2 diabetes. Thus, focus is now shifting towards searching also for rare variants using new high-throughput sequencing technologies. For genes involved in the genetic predisposition to type 2 diabetes the emerging picture is that there are hundreds of different gene variants working in a complex interplay influencing pancreatic beta cell function/mass and, only to a lesser extent, insulin action. Several Norwegian studies have contributed to the field, extending our understanding of genetic risk factors in type 2 diabetes and in diabetes-related phenotypes like obesity and cardiovascular disease.

  7. A review on the mass spectrometric studies of americium: Present status and future perspective.

    Science.gov (United States)

    Aggarwal, Suresh Kumar

    2018-01-01

    The manuscript reviews the various mass spectrometric techniques for analysis and chemical studies of Americium. These methods include thermal ionization mass spectrometry (TIMS), and inductively coupled plasma source mass spectrometry (ICPMS) for the determination of Am isotope ratios and concentration in nuclear fuel samples of interest in nuclear technology, and in complex biological and environmental samples. Ultra-sensitive mass spectrometric techniques of resonance-ionization mass spectrometry (RIMS), and accelerator-based mass spectrometry (AMS) are also discussed. The novel applications of electrospray ionization mass spectrometry (ESIMS) to understand the solution chemistry of Am and other actinides are presented. These studies are important in view of the world-wide efforts to develop novel complexing agents to separate lanthanides and minor actinides (Am, Np, and Cm) for partitioning and transmutation of minor actinides from the point of view of nuclear waste management. These mass spectrometry experiments are also of great interest to examine the covalent character of actinides with increasing atomic number. Studies on gas-phase chemistry of Am and its oxides with Knudsen effusion mass spectrometry (KEMS), Fourier-transform ion cyclotron resonance mass spectrometry (FTICR-MS), and laser-based experiments with reflectron time-of-flight mass spectrometer (R-ToF) are highlighted. These studies are important to understand the fundamental chemistry of 5f electrons in actinides. Requirement of certified isotopic reference materials of Am to improve the accuracy of experimental nuclear data (e.g., the half-life of 243 Am) is emphasized. © 2016 Wiley Periodicals, Inc. Mass Spec Rev. © 2016 Wiley Periodicals, Inc.

  8. Behavioural present value

    OpenAIRE

    Krzysztof Piasecki

    2013-01-01

    Impact of chosen behavioural factors on imprecision of present value is discussed here. The formal model of behavioural present value is offered as a result of this discussion. Behavioural present value is described here by fuzzy set. These considerations were illustrated by means of extensive numerical case study. Finally there are shown that in proposed model the return rate is given, as a fuzzy probabilistic set.

  9. Testing a Poisson counter model for visual identification of briefly presented, mutually confusable single stimuli in pure accuracy tasks.

    Science.gov (United States)

    Kyllingsbæk, Søren; Markussen, Bo; Bundesen, Claus

    2012-06-01

    The authors propose and test a simple model of the time course of visual identification of briefly presented, mutually confusable single stimuli in pure accuracy tasks. The model implies that during stimulus analysis, tentative categorizations that stimulus i belongs to category j are made at a constant Poisson rate, v(i, j). The analysis is continued until the stimulus disappears, and the overt response is based on the categorization made the greatest number of times. The model was evaluated by Monte Carlo tests of goodness of fit against observed probability distributions of responses in two extensive experiments and also by quantifications of the information loss of the model compared with the observed data by use of information theoretic measures. The model provided a close fit to individual data on identification of digits and an apparently perfect fit to data on identification of Landolt rings.

  10. Presentation of studies on the bacterium helicobacter pylori at Maribor teaching hospital between 1988 and 2005

    Directory of Open Access Journals (Sweden)

    Jelka Reberšek-Gorišek

    2006-12-01

    study, ranitidine 2 × 150 mg + colloidal bismuth subcitrate (CBS 2 × 240 mg over 4 weeks in the second study, and CBS 4 × 120 mg + amoxycillin 4 × 500 mg + metronidazole 4 × 500 mg over two weeks in the third study. With the latex agglutination and with the enzyme immune system (Virion-Serion we identified IgG and IgA antibodies against H. pylori in serum, and antigen in feces (HpSA – Meridian. In protocols of epidemiologic characteristics of H. pylori infection we collected and analyzed the data regarding patient age and gender, living and sanitary conditions, socio-economic status and the education level.Results: The studies showed that H. pylori was most frequently present in ulcer disease of duodenum and stomach. The success of antimicrobial treatment and eradication of H. pylori with ranitidine and erythromycin over one week was 11.1 %, with the combination of ranitidine and CBS over four weeks 19.04 %, with the triple combination therapy with CBS + amoxycillin + metronidazole over two weeks 92 %. In dental plaque, H. pylori was confirmed in 16.6 %. Middle age, poor or medium living conditions and economic status, and primary to secondary education were all identified as possible risk factors for H. pylori infection. In asymptomatic patients we confirmed IgG antibodies against H. pylori in serum in 26/34, in 1/34 they were borderline positive, and negative in 7/34 patients. IgA antibodies were present in 17/34, in 6/34 they were borderline positive, and negative in 11/34. Antigen in feces was positive in 10/33 patients, negative in 23/33. Serum IgG and IgA antibodies and antigen in feces were confirmed in 8/23 patients.Conclusions: Our studies resulted in the beginning of H. pylori detection in MTH patients with gastritis and ulcer disease, and in the ascertainment that H. pylori was most frequently present in ulcer disease of stomach and duodenum. For the confirmation of H. pylori, the histologic method, culture and the urease test were introduced

  11. DVT presentations to an emergency department: a study of guideline based care and decision making

    LENUS (Irish Health Repository)

    Lillis, D

    2016-02-01

    Pre-test probability scoring and blood tests for deep venous thrombosis (DVT) assessment are sensitive, but not specific leading to increased demands on radiology services. Three hundred and eighty-five patients presenting to an Emergency Department (ED), with suspected DVT, were studied to explore our actual work-up of patients with possible DVT relating to risk stratification, further investigation and follow up. Of the 205 patients with an initially negative scan, 36 (17.6%) were brought for review to the ED Consultant clinic. Thirty-four (16.6%) patients underwent repeat compression ultrasound with 5 (2.4%) demonstrating a DVT on the second scan. Repeat compression ultrasound scans were performed on 34 (16.6%) patients with an initially negative scan, with essentially the same diagnostic yield as other larger studies where 100% of such patients had repeat scanning. Where there is ongoing concern, repeat above-knee compression ultrasound within one week will pick up a small number of deep venous thromboses.

  12. How can present and future satellite missions support scientific studies that address ocean acidification?

    Science.gov (United States)

    Salisbury, Joseph; Vandemark, Douglas; Jonsson, Bror; Balch, William; Chakraborty, Sumit; Lohrenz, Steven; Chapron, Bertrand; Hales, Burke; Mannino, Antonio; Mathis, Jeremy T.; Reul, Nicolas; Signorini, Sergio; Wanninkhof, Rik; Yates, Kimberly K.

    2016-01-01

    Space-based observations offer unique capabilities for studying spatial and temporal dynamics of the upper ocean inorganic carbon cycle and, in turn, supporting research tied to ocean acidification (OA). Satellite sensors measuring sea surface temperature, color, salinity, wind, waves, currents, and sea level enable a fuller understanding of a range of physical, chemical, and biological phenomena that drive regional OA dynamics as well as the potentially varied impacts of carbon cycle change on a broad range of ecosystems. Here, we update and expand on previous work that addresses the benefits of space-based assets for OA and carbonate system studies. Carbonate chemistry and the key processes controlling surface ocean OA variability are reviewed. Synthesis of present satellite data streams and their utility in this arena are discussed, as are opportunities on the horizon for using new satellite sensors with increased spectral, temporal, and/or spatial resolution. We outline applications that include the ability to track the biochemically dynamic nature of water masses, to map coral reefs at higher resolution, to discern functional phytoplankton groups and their relationships to acid perturbations, and to track processes that contribute to acid variation near the land-ocean interface.

  13. Marketing faculty of Bucharest Economic Studies University: historic landmarks, present and future developments

    Directory of Open Access Journals (Sweden)

    Călin Petrică Vegheş

    2013-06-01

    Full Text Available This paper aims to present the main events that left their mark on the history and evolution of the Marketing Faculty of Bucharest Economic Studies University, an academic body that this will mark its 10th anniversary this fall. As the only school dedicated exclusively to the study of marketing in Romania, as well as one of the few exclusively marketing schools in Europe, the history of the Marketing Department and, subsequently, of the Marketing Faculty overlaps in the last four decades with that of Romanian marketing higher education, as well as with the graduate transformation of Romania’s economy to a post-industrial, information-based and customer centric economy. Part of Economic Sciences domain, marketing contains a set of concepts, tools, methods and techniques through which the organization, irrespective of its profile, analyzes the environment where it lives (marketing research, sets goals and strategies to be achieved (strategic marketing planning, design and execute operational activities (marketing programs in order to maximize profits and to satisfy customer’s and society’s needs at the required level. Marketing as a strategic and operational area, captures the interest of Romanian managers and specialists of international organizations, being a source of competitive advantage and positioning of the company and its portfolio brands, in the mind and soul of current and potential customers

  14. A single-column model intercomparison on the stratocumulus representation in present-day and future climate

    NARCIS (Netherlands)

    Dal Gesso, S.; Van der Dussen, J.J.; Siebesma, A.P.; De Roode, S.R.; Boutle, I.A.; Kamae, Y.; Roehrig, R.; Vial, J.

    2015-01-01

    Six Single-Column Model (SCM) versions of climate models are evaluated on the basis of their representation of the dependence of the stratocumulus-topped boundary layer regime on the free tropospheric thermodynamic conditions. The study includes two idealized experiments corresponding to the

  15. Overhead distribution line models for harmonics studies

    Energy Technology Data Exchange (ETDEWEB)

    Nagpal, M.; Xu, W.; Dommel, H.W.

    1994-01-01

    Carson's formulae and Maxwell's potential coefficients are used for calculating the per unit length series impedances and shunt capacitances of the overhead lines. The per unit length values are then used for building the models, nominal pi-circuit, and equivalent pi-circuit at the harmonic frequencies. This paper studies the accuracy of these models for presenting the overhead distribution lines in steady-state harmonic solutions at frequencies up to 5 kHz. The models are verified with a field test on a 25 kV distribution line and the sensitivity of the models to ground resistivity, skin effect, and multiple grounding is reported.

  16. NURE uranium deposit model studies

    International Nuclear Information System (INIS)

    Crew, M.E.

    1981-01-01

    The National Uranium Resource Evaluation (NURE) Program has sponsored uranium deposit model studies by Bendix Field Engineering Corporation (Bendix), the US Geological Survey (USGS), and numerous subcontractors. This paper deals only with models from the following six reports prepared by Samuel S. Adams and Associates: GJBX-1(81) - Geology and Recognition Criteria for Roll-Type Uranium Deposits in Continental Sandstones; GJBX-2(81) - Geology and Recognition Criteria for Uraniferous Humate Deposits, Grants Uranium Region, New Mexico; GJBX-3(81) - Geology and Recognition Criteria for Uranium Deposits of the Quartz-Pebble Conglomerate Type; GJBX-4(81) - Geology and Recognition Criteria for Sandstone Uranium Deposits in Mixed Fluvial-Shallow Marine Sedimentary Sequences, South Texas; GJBX-5(81) - Geology and Recognition Criteria for Veinlike Uranium Deposits of the Lower to Middle Proterozoic Unconformity and Strata-Related Types; GJBX-6(81) - Geology and Recognition Criteria for Sandstone Uranium Deposits of the Salt Wash Type, Colorado Plateau Province. A unique feature of these models is the development of recognition criteria in a systematic fashion, with a method for quantifying the various items. The recognition-criteria networks are used in this paper to illustrate the various types of deposits

  17. Present and future radioactive beam studies at GANIL. From SISSI to SPIRAL

    International Nuclear Information System (INIS)

    Guerreau, D.

    1996-01-01

    The present status of radioactive beam developments at GANIL is discussed. The emphasis is put on the construction of the new SPIRAL radioactive beam facility presently underway and of the main trends in physics. (author)

  18. Present studies on the radio-sterilized drugs; Aktualny stan badan nad lekami sterylizowanymi radiacyjnie

    Energy Technology Data Exchange (ETDEWEB)

    Marciniec, B; Dettlaff, K [Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poznan (Poland)

    2007-07-01

    Lecture presents present status of radiosterilization of drugs and medical materials as compared to other sterilization methods. Literature review is shown on degradation of different kinds of drugs sterilized upon action of the sterilising doses of radiation.

  19. Clinical Presentation and Microbial Analyses of Contact Lens Keratitis; an Epidemiologic Study

    Directory of Open Access Journals (Sweden)

    Seyed Ahmad Rasoulinejad

    2014-09-01

    Full Text Available Introduction: Microbial keratitis is an infective process of the cornea with a potentially and serious visual impairments. Contact lenses are a major cause of microbial keratitis in the developed countries especially among young people. Therefore, the purpose of the present study was to evaluate the frequency and microbiological characteristic of CLK in patients referred to the emergency department (ED of teaching hospitals, Babol, Iran. Methods: This is a cross-sectional study of all patients with contact lens induced corneal ulcers admitted to the teaching hospitals of Babol, Iran, from 2011- 2013. An ophthalmologist examined patients with the slit-lamp and clinical features of them were noted (including pain, redness, foreign body sensation, chemosis, epiphora, blurred vision, discomfort, photophobia, discharge, ocular redness and swelling. All suspected infectious corneal ulcers were scraped for microbial culture and two slides were prepared. Data were analyzed using SPSS software, version 18.0. Results: A total of 14 patients (17 eyes were recruited into the study (100% female. The patients’ age ranged from 16-37 years old (mean age 21.58±7.23 years. The most prevalent observed clinical signs were pain and redness. Three samples reported as sterile. The most common isolated causative organism was pseudomonas aeroginosa (78.6%, Staphylococcus aureus 14.3%, and enterobacter 7.1%, respectively. Treatment outcome was excellent in 23.5%, good in 47.1%, and poor in 29.4% of cases. Conclusion: Improper lens wear and care as well as the lack of awareness about the importance of aftercare visits have been identified as potential risk factors for the corneal ulcer among contact lens wearers. Training and increasing the awareness of adequate lens care and disinfection practices, consulting with an ophthalmologist, and frequent replacement of contact lens storage cases would greatly help reducing the risk of microbial keratitis.

  20. A Multicenter Study of the Presentation, Treatment, and Outcomes of Cervical Dural Tears.

    Science.gov (United States)

    O'Neill, Kevin R; Fehlings, Michael G; Mroz, Thomas E; Smith, Zachary A; Hsu, Wellington K; Kanter, Adam S; Steinmetz, Michael P; Arnold, Paul M; Mummaneni, Praveen V; Chou, Dean; Nassr, Ahmad; Qureshi, Sheeraz A; Cho, Samuel K; Baird, Evan O; Smith, Justin S; Shaffrey, Christopher; Tannoury, Chadi A; Tannoury, Tony; Gokaslan, Ziya L; Gum, Jeffrey L; Hart, Robert A; Isaacs, Robert E; Sasso, Rick C; Bumpass, David B; Bydon, Mohamad; Corriveau, Mark; De Giacomo, Anthony F; Derakhshan, Adeeb; Jobse, Bruce C; Lubelski, Daniel; Lee, Sungho; Massicotte, Eric M; Pace, Jonathan R; Smith, Gabriel A; Than, Khoi D; Riew, K Daniel

    2017-04-01

    Retrospective multicenter case series study. Because cervical dural tears are rare, most surgeons have limited experience with this complication. A multicenter study was performed to better understand the presentation, treatment, and outcomes following cervical dural tears. Multiple surgeons from 23 institutions retrospectively identified 21 rare complications that occurred between 2005 and 2011, including unintentional cervical dural tears. Demographic data and surgical history were obtained. Clinical outcomes following surgery were assessed, and any reoperations were recorded. Neck Disability Index (NDI), modified Japanese Orthopaedic Association (mJOA), Nurick classification (NuC), and Short-Form 36 (SF36) scores were recorded at baseline and final follow-up at certain centers. All data were collected, collated, and analyzed by a private research organization. There were 109 cases of cervical dural tears among 18 463 surgeries performed. In 101 cases (93%) there was no clinical sequelae following successful dural tear repair. There were statistical improvements ( P < .05) in mJOA and NuC scores, but not NDI or SF36 scores. No specific baseline or operative factors were found to be associated with the occurrence of dural tears. In most cases, no further postoperative treatments of the dural tear were required, while there were 13 patients (12%) that required subsequent treatment of cerebrospinal fluid drainage. Analysis of those requiring further treatments did not identify an optimum treatment strategy for cervical dural tears. In this multicenter study, we report our findings on the largest reported series (n = 109) of cervical dural tears. In a vast majority of cases, no subsequent interventions were required and no clinical sequelae were observed.

  1. Parental responses to child experiences of trauma following presentation at emergency departments: a qualitative study.

    Science.gov (United States)

    Williamson, Victoria; Creswell, Cathy; Butler, Ian; Christie, Hope; Halligan, Sarah L

    2016-11-07

    Parents are often children's main source of support following fear-inducing traumatic events, yet little is known about how parents provide that support. The aim of this study was to examine parents' experiences of supporting their child following child trauma exposure and presentation at an emergency department (ED). Semistructured qualitative interviews analysed using thematic analysis. The setting for this study was two National Health Service EDs in England. 20 parents whose child experienced a traumatic event and attended an ED between August 2014 and October 2015. Parents were sensitive to their child's distress and offered reassurance and support for their child to resume normal activities. However, parental beliefs often inhibited children's reinstatement of pretrauma routines. Support often focused on preventing future illness or injury, reflective of parents' concerns for their child's physical well-being. In a minority of parents, appraisals of problematic care from EDs contributed to parents' anxiety and perceptions of their child as vulnerable post-trauma. Forgetting the trauma and avoidance of discussion were encouraged as coping strategies to prevent further distress. Parents highlighted their need for further guidance and support regarding their child's physical and emotional recovery. This study provides insight into the experiences of and challenges faced by parents in supporting their child following trauma exposure. Perceptions of their child's physical vulnerability and treatment influenced parents' responses and the supportive strategies employed. These findings may enable clinicians to generate meaningful advice for parents following child attendance at EDs post-trauma. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  2. Design, analysis and presentation of multinational economic studies: the need for guidance.

    Science.gov (United States)

    Pang, Francis

    2002-01-01

    Over the last decade, there has been a proliferation in the number of economic evaluations of pharmaceuticals to meet the growing demand for information about the economic benefits of healthcare technologies. The majority of these studies have been commissioned by pharmaceutical companies for the purposes of drawing attention to the resource and quality-of-life aspects of new or existing products. Such information has become important in overcoming a new obstacle, namely the demonstration of cost effectiveness (the so-called 'fourth hurdle'), in addition to the three well-established criteria of quality, tolerability and efficacy. To ensure the maintenance of standards, guidance for economic evaluations has emerged lately in the form of guidelines, regulations, principles, policies and positions. Drummond outlined three purposes of these guidelines, as follows: as a requirement prior to reimbursement, as statements of methodological standards, and as a statement of ethical standards. Such guidelines are designed to assist both the economic analyst and the decision-maker. In laying out the state of the art regarding the methodology of economic evaluation, guidelines assist the analyst in performing high-quality, scientifically valid studies, and assist the decision-maker in properly interpreting and assessing their quality. In response to these growing requirements for cost-effectiveness data globally, it has become increasingly common for economic evaluations to be conducted on an international scale. However, the recommendations in pharmacoeconomics guidelines regarding the manner in which these multinational economic evaluations should be designed, analysed and presented are too limited to be of any real value. This article examines the various issues that must be taken into consideration when conducting multinational studies, and provides a review of the techniques and approaches that have been suggested to date. It concludes with recommendations for potential

  3. Perfectionistic Self-Presentation, Socially Prescribed Perfectionism, and Suicide in Youth: A Test of the Perfectionism Social Disconnection Model

    Science.gov (United States)

    Roxborough, Heather M.; Hewitt, Paul L.; Kaldas, Janet; Flett, Gordon L.; Caelian, Carmen M.; Sherry, Simon; Sherry, Dayna L.

    2012-01-01

    The role of interpersonal components of perfectionism in suicide outcomes among youth was assessed and the Perfectionism Social Disconnection Model (PSDM) was tested by determining whether the links between socially prescribed perfectionism (SPP) and perfectionistic self-presentation (PSP) and suicide outcomes are mediated by experiences of social…

  4. Studies of neutrino properties at nuclear reactors. Present status and future

    CERN Document Server

    Mikaehlyan, L A

    2002-01-01

    The state and prospects of the experiments at nuclear reactors on the search for the neutrino mass, mixing and magnetic moments, identification whereof would prove the existence of events behind the standard model limits, are considered. The CHOOZ experiment established with complete determination, that the nu sub e -> nu sub x channel is not predominant in the atmospheric neutrino oscillations. The KamLAND may become the first among the experiments with the neutrino earth sources, wherein the oscillation effect will be determined; the contributions of the m sub 1 and m sub 2 masses to the electron neutrino is established and solution of the solar neutrino problem is found. The Kr2Det experiment with its high sensitivity to the small mixing angles may identify the contribution of the m sub 3 mass to the nu sub e or establish a new more exact limit on its value. These studies rest upon the unprecedented improvement of the reverse beta-decay registration methods

  5. A prospective cohort study of the clinical presentation of non-traumatic osteonecrosis of the femoral head: spine and knee symptoms as clinical presentation of hip osteonecrosis.

    Science.gov (United States)

    Hauzeur, Jean-Philippe; Malaise, Michel; de Maertelaer, Viviane

    2016-07-01

    To study the clinical presentation of femoral head osteonecrosis (ONFH). Publications dedicated to this aspect of ONFH are rare. Our aim was to systematically collect and describe the clinical data. A prospective survey was conducted in a cohort of ONFH recruited from a dedicated clinic for osteonecrosis. The history of symptoms, medical management, and physical findings were obtained from 88 patients suffering from 125 ONFH. Subgroups were formed: bilateral versus unilateral ONFH, radiological stages 1-2 (pre-fractured) versus fractured stage 3 versus stage 4. ONFH was bilateral in 63 %, especially in corticosteroid users and in sickle-cell cases. These patients were younger but had similar BMIs compared to the unilateral cases. The pain was mechanical in 79 % of hips and inflammatory in 21 %. Acute pain at the onset was present in 55 % of hips. The localization of this pain was variable, including in the groin, the buttocks, or diffused in the lower limbs. A limp was present in 50 % of the patients, only when one hip was painful. The physical examination of the hip was normal in 31 %, especially in stages 1-2 (55 %). The diagnosis delay was 12 months, with inadequate medical management in 51 % of patients. In ONFH cases, no typical clinical pattern was found. The clinical presentation was very variable, sometimes having spine or knee symptoms with a normal physical examination of the hip. ONFH should be systematically suspected in cases of onset of pain in the pelvis, buttocks, groin, and lower limbs.

  6. Present activity of the feasibility study of HTGR-GT system

    International Nuclear Information System (INIS)

    Muto, Y.; Miyamoto, Y.; Shiozawa, S.

    2001-01-01

    In JAERI a feasibility study of the High Temperature Gas-cooled Reactor-Gas Turbine (HTGR-GT) system has been carried out since January, 1997 as an assigned work by the Science and Technology Agency. The study aims at obtaining a promising concept of HTGR-GT system that yields a high thermal efficiency and at the same time is economically competitive. Designs of a few candidate systems will be undertaken and their power generation costs will be evaluated in parallel with design works, some experimental works such as the fabrication of a plate-fin type heat exchanger core and material tests will be carried out. The study will be continued till 2000 fiscal year. In 1997 fiscal year, a preliminary design of a direct cycle plant of 600 MWt was developed. A reactor inlet gas temperature of 460 deg. C, a reactor outlet gas temperature of 850 deg. C and a helium gas pressure of 6MPa were selected. Some advanced technologies were adopted such as a monolithic fuel compact and a control rod sheath made of carbon/carbon composite material. They were very effective to enhance the heat transfer of fuel and to reduce the core bypass flow. As a result, a power density of 6MW/m 3 and the maximum burnup of 10 5 MWD/ton were achieved. A single-shaft horizontal turbomachine of 3600 rpm was selected to ease the mechanical design of the rotor supported by magnetic bearings. The turbine, two compressors, a generator and six units of intercooler were placed in a turbine vessel, Plate-fin type recuperator and precooler are installed in a vertical heat exchanger vessel. By this design, a net thermal efficiency of 45.7% is expected to be achieved. To develop a high performance plate-fin recuperator, a core model of W200 mm x L200 mm x H200 mm with small fin size of 1.15 mm height was fabricated and as a result of tests, leak tightness, component strength and bonding appearance were found to be satisfactory. In 1998 fiscal year, a design of a direct cycle plant of 300 MWt is undertaken. The

  7. Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study.

    Science.gov (United States)

    Mendel, M; Chłopecka, M; Dziekan, N; Karlik, W

    2016-09-01

    Flavonoid supplementation is likely to be beneficial in improving rumen fermentation and in reducing the incidence of rumen acidosis and bloat. Flavonoids are also said to increase the metabolic performance during the peripartum period. Ruminants are constantly exposed to flavonoids present in feed. However, it is not clear if these phytochemicals can affect the activity of the gut smooth muscle. Therefore, the aim of the study was to verify the effect of three flavonoids on bovine isolated abomasum smooth muscle. The study was carried out on bovine isolated circular and longitudinal abomasal smooth muscle specimens. All experiments were conducted under isometric conditions. The effect of apigenin, luteolin and quercetin (0.001 to 100 µM) was evaluated on acetylcholine-precontracted preparations. The effect of multiple, but not cumulative, treatment and single treatment with each flavonoid on abomasum strips was compared. Apigenin (0.1 to 100 µM) dose-dependently showed myorelaxation effects. Luteolin and quercetin applied in low doses increased the force of the ACh-evoked reaction. However, if used in high doses in experiments testing a wide range of concentrations, their contractile effect either declined (luteolin) or was replaced by an antispasmodic effect (quercetin). Surprisingly, the reaction induced by flavonoids after repeated exposure to the same phytochemical was not reproducible in experiments testing only single exposure of abomasum strips to the same flavonoid used in a high concentration. Taking into account the physicochemical properties of flavonoids, this data suggests the ability of flavonoids to interfere with cell membranes and, subsequently, to modify their responsiveness. Assuming ruminant supplementation with luteolin or quercetin or their presence in daily pasture, a reduction of the likelihood of abomasum dysmotility should be expected.

  8. Clinical and ultrasonographic study of patients presenting with transvaginal mesh complications.

    Science.gov (United States)

    Manonai, Jittima; Rostaminia, Ghazaleh; Denson, Lindsay; Shobeiri, S Abbas

    2016-03-01

    The objective of this study was to investigate the clinical and ultrasonographic findings of women who had three-dimensional endovaginal ultrasound (EVUS) for the management of vaginal mesh complications. This was a retrospective study of patients that had EVUS due to mesh complications at a tertiary care center. The clinical charts were reviewed. The stored 3D volumes were reviewed regarding mesh information by two examiners independently. The predictive value of physical examination for detection of vaginal mesh was calculated. Patient outcomes were reviewed. Seventy-nine patients presented to our center because of their, or their physicians' concern regarding mesh complications. Forty-one (51.9%) had vaginal/pelvic pain, and 51/62 (82.2%) of sexually active women experienced dyspareunia. According to ultrasonographic findings, mesh or sling was not demonstrated in six patients who believed they have had mesh/sling implantation. The positive predictive value for vaginal examination was 94.5% (95% CI: 84.9%-98.8%), negative predictive value was 12.5% (95% CI: 2.8%-32.4%), sensitivity was 72.2% (95% CI: 59.4%-81.2%), and specificity was 50.0% (95% CI: 12.4%-87.6%). Fifty-four patients were indicated for surgical treatment. Median postoperative review was 12 (range, 3-18) months and 38/53 (71.7%) patients were satisfied. The most common complaints of vaginal mesh complications were pain and dyspareunia. EVUS appeared to be helpful for assessing mesh presence, location, and extent including planning for surgical intervention. © 2015 Wiley Periodicals, Inc.

  9. A pilot cross-sectional study of patients presenting with cellulitis to emergency departments.

    LENUS (Irish Health Repository)

    Quirke, M

    2014-11-01

    To characterise the Emergency Department (ED) prevalence of cellulitis, factors predicting oral antibiotic therapy and the utility of the Clinical Resource Efficiency Support Team (CREST) guideline in predicting patient management in the ED setting, a prospective, cross-sectional study of consecutive adult patients presenting to 3 Irish EDs was performed. The overall prevalence of cellulitis was 12 per 1,000 ED visits. Of 59 patients enrolled, 45.8% were discharged. Predictors of treatment with oral antibiotics were: CREST, Class 1 allocation (odds ratio (OR) 6.81, 95% Cl =1.5-30.1, p=0.012), patient self-referral (OR= 6.2, 95% Cl 1.9- 20.0, p=0.03) and symptom duration longer than 48 hours (OR 1.2, 95% Cl = 1.0-1.5,p=0.049). In conflict with guideline recommendation, 43% of patients in CREST Class 1 received IV therapy. Treatment with oral antibiotics was predicted by CREST Class 1 allocation, self-referral, symptom duration of more than 48 hours and absence of pre-EO antibiotic therapy.

  10. Incidence of malignancy in females presenting with breast lumps in OPD: a study of 277 cases

    International Nuclear Information System (INIS)

    Chaudhary, I.A.; Qureshi, S.K.; Rasul, S.

    2003-01-01

    Objective: To find the incidence of malignancy in females presenting with breast lumps in surgical out patient and to find out the age related incidence of benign and malignant diseases in these patients. Patients and Methods: All cases reporting to surgical outdoor with breast lumps were included and underwent investigation for the breast lumps to determine the histopathological diagnosis. Results: A total of 277 cases were studied. 24.2% breast lumps were malignant and 75.8% were benign. The incidence of malignancy increases from 0% in 2nd decade to 38.9% in 5th and 100% in 9th decade of life. The probability of diagnosing a breast lump as a malignant is one in three in 4th decade, two in five in 5th decade and more than one in two there after. Fibrocystic disease (33.8%) and Fibro adenoma (27.1%) was the commonest finding among the benign lumps. Among malignant lumps infiltrating duct carcinoma (68.7%) is the commonest finding. Conclusion: There is a significantly high incidence of malignant breast lumps after the 3rd decade of life and it increases subsequently. It is recommended that the surgeon managing a case of breast lump in a patient above 30 years should be highly suspicious and cautious so that early detection and management of malignant lumps be carried out. (author)

  11. The Real Cost of "Cosmetic Tourism" Cost Analysis Study of "Cosmetic Tourism" Complications Presenting to a Public Hospital.

    Science.gov (United States)

    Livingston, Ryan; Berlund, Paul; Eccles-Smith, Jade; Sawhney, Raja

    2015-01-01

    "Cosmetic Tourism," the process of traveling overseas for cosmetic procedures, is an expanding global phenomenon. The model of care by which these services are delivered can limit perioperative assessment and postoperative follow-up. Our aim was to establish the number and type of complications being treated by a secondary referral hospital resulting from "cosmetic tourism" and the cost that has been incurred by the hospital in a 1-year period. Retrospective cost analysis and chart review of patients admitted to the hospital between the financial year of 2012 and 2013 were performed. Twelve "cosmetic tourism" patients presented to the hospital, requiring admission during the study period. Breast augmentation was the most common procedure and infected prosthesis was the most common complication (n = 4). Complications ranged from infection, pulmonary embolism to penile necrosis. The average cost of treating these patients was $AUD 12 597.71. The overall financial burden of the complication to the hospital was AUD$151 172.52. The "cosmetic tourism" model of care appears to be, in some cases, suboptimal for patients and their regional hospitals. In the cases presented in this study, it appears that care falls on the patient local hospital and home country to deal with the complications from their surgery abroad. This incurs a financial cost to that hospital in addition to redirecting medical resources that would otherwise be utilized for treating noncosmetic complications, without any remuneration to the local provider.

  12. Presenting a Model Based on Fuzzy Application to Optimize the Time of IBS Projects in Gas Refineries

    Directory of Open Access Journals (Sweden)

    Naderpour Abbas

    2017-01-01

    Full Text Available Nowadays, the construction industry has started to embrace IBS as a method of attaining better construction quality and productivity and reducing risks related to occupational safety and health. The built of pre-fabricated component in factories reduces many problems related to lack of purposing uncertainty in scheduling calculation and time management of projects. In the case of using IBS method for managing time in projects, former studies such as Allan Tay’s research, indicates that this method can save up at least 29% of overall completion period versus the conventional method. But beside mentioned advantages of this technical method, the projects could be optimized more and more in scheduling calculations. This issue is critical in gas refineries, since special parameters such as risk of spreading poison H2S gas and mandatory of performing projects in short time period events such as maintenance overhauls demands to perform projects in optimum time. Custom scheduling calculation of project planning uses the Critical Path Method (CPM as a tool for Planning Project’s activities. The researches of this paper’s authors indicated that Fuzzy Critical Path Method (FCPM is the best technique to manage the uncertainty in project scheduling and can save up the construction project’s time versus the custom methods. This paper aims to present a model based on fuzzy application in CPM calculations to optimize the time of Industrial Building System.

  13. Methodological developments in searching for studies for systematic reviews: past, present and future?

    Science.gov (United States)

    Lefebvre, Carol; Glanville, Julie; Wieland, L Susan; Coles, Bernadette; Weightman, Alison L

    2013-09-25

    The Cochrane Collaboration was established in 1993, following the opening of the UK Cochrane Centre in 1992, at a time when searching for studies for inclusion in systematic reviews was not well-developed. Review authors largely conducted their own searches or depended on medical librarians, who often possessed limited awareness and experience of systematic reviews. Guidance on the conduct and reporting of searches was limited. When work began to identify reports of randomized controlled trials (RCTs) for inclusion in Cochrane Reviews in 1992, there were only approximately 20,000 reports indexed as RCTs in MEDLINE and none indexed as RCTs in Embase. No search filters had been developed with the aim of identifying all RCTs in MEDLINE or other major databases. This presented The Cochrane Collaboration with a considerable challenge in identifying relevant studies.Over time, the number of studies indexed as RCTs in the major databases has grown considerably and the Cochrane Central Register of Controlled Trials (CENTRAL) has become the best single source of published controlled trials, with approximately 700,000 records, including records identified by the Collaboration from Embase and MEDLINE. Search filters for various study types, including systematic reviews and the Cochrane Highly Sensitive Search Strategies for RCTs, have been developed. There have been considerable advances in the evidence base for methodological aspects of information retrieval. The Cochrane Handbook for Systematic Reviews of Interventions now provides detailed guidance on the conduct and reporting of searches. Initiatives across The Cochrane Collaboration to improve the quality inter alia of information retrieval include: the recently introduced Methodological Expectations for Cochrane Intervention Reviews (MECIR) programme, which stipulates 'mandatory' and 'highly desirable' standards for various aspects of review conduct and reporting including searching, the development of Standard Training

  14. A statistical study of weather-related disasters. Past, present and future

    Energy Technology Data Exchange (ETDEWEB)

    Visser, H.; Bouwman, A.; Petersen, A.; Ligtvoet, W.

    2012-07-15

    Disasters such as floods, storms, heatwaves and droughts may have serious implications for human health and the economic development of countries. One of the main findings of this report is that disaster burdens are dominated by economic and demographic developments, rather than climate change. Furthermore, disaster burden appears to be spread unequally over rich and poor countries. In Chapter 2 the background of the three regions used throughout this report is described: OECD, BRIICS (Brazil, Russia, India, Indonesia, China and South Africa and remaining countries. Furthermore, an overview of the disaster databases is given, along with definitions of disaster terminology. The statistical treatment of trends in disaster data is shortly exemplified. Chapter 3 gives on overview of the results for disaster burden and trends therein on a global scale. Results are split-up as for different disaster types. In Chapters 4 and 5 the same analysis is performed, but now split-up for three regions. In Chapter 4, disaster burdens are quantified, while analyses of trends in disaster burdens are given in Chapter 5. Here, the analyses are confined to weather-related disaster events only. In Chapter 6 the trend patterns found in Chapter 5, are explained as far as possible. Here, changes in wealth, changes in population, the role of climate change and changes due to adaptation are treated in separate sections. Chapter 7 shortly deals with communicational aspects of disasters: the attribution of individual disasters to climate change and results in the literature which are contradictory to results presented here. Chapters 3 through 7 deal with historical data on disaster burden. In the subsequent Chapters 8 and 9 the future of disaster burden will be dealt with. Chapter 8 gives a short overview of the future of disasters as presented in the literature. In Chapter 9 a PBL case study for flooding on a global scale is given, with predictions for people at risk and economic losses at

  15. Mixed models in cerebral ischemia study

    Directory of Open Access Journals (Sweden)

    Matheus Henrique Dal Molin Ribeiro

    2016-06-01

    Full Text Available The data modeling from longitudinal studies stands out in the current scientific scenario, especially in the areas of health and biological sciences, which induces a correlation between measurements for the same observed unit. Thus, the modeling of the intra-individual dependency is required through the choice of a covariance structure that is able to receive and accommodate the sample variability. However, the lack of methodology for correlated data analysis may result in an increased occurrence of type I or type II errors and underestimate/overestimate the standard errors of the model estimates. In the present study, a Gaussian mixed model was adopted for the variable response latency of an experiment investigating the memory deficits in animals subjected to cerebral ischemia when treated with fish oil (FO. The model parameters estimation was based on maximum likelihood methods. Based on the restricted likelihood ratio test and information criteria, the autoregressive covariance matrix was adopted for errors. The diagnostic analyses for the model were satisfactory, since basic assumptions and results obtained corroborate with biological evidence; that is, the effectiveness of the FO treatment to alleviate the cognitive effects caused by cerebral ischemia was found.

  16. Voting Present

    Directory of Open Access Journals (Sweden)

    James Lo

    2013-12-01

    Full Text Available During his time as a state senator in Illinois, Barack Obama voted “Present” 129 times, a deliberate act of nonvoting that subsequently became an important campaign issue during the 2008 presidential elections. In this article, I examine the use of Present votes in the Illinois state senate. I find evidence that Present votes can largely be characterized as protest votes used as a legislative tool by the minority party. Incorporating information from Present votes into a Bayesian polytomous item-response model, I find that this information increases the efficiency of ideal point estimates by approximately 35%. There is little evidence of significant moderation by Obama when Present votes are accounted for, though my results suggest that Obama’s voting record may have moderated significantly before his subsequent election to the U.S. Senate. My results also suggest that because legislative nonvoting may occur for a variety of reasons, naive inclusion of nonvoting behavior into vote choice models may lead to biased results.

  17. Saltstone SDU6 Modeling Study

    International Nuclear Information System (INIS)

    Lee, Si Y.; Hyun, Sinjae

    2013-01-01

    A new disposal unit, designated as Saltstone Disposal Unit 6 (SDU6), is being designed for support of site accelerated closure goals and salt waste projections identified in the new Liquid Waste System Plan. The unit is a cylindrical disposal cell of 375 ft in diameter and 43 ft in height, and it has a minimum 30 million gallons of capacity. SRNL was requested to evaluate the impact of an increased grout placement height on the flow patterns radially spread on the floor and to determine whether grout quality is impacted by the height. The primary goals of the work are to develop the baseline Computational Fluid Dynamics (CFD) model and to perform the evaluations for the flow patterns of grout material in SDU6 as a function of elevation of grout discharge port and grout rheology. Two transient grout models have been developed by taking a three-dimensional multiphase CFD approach to estimate the domain size of the grout materials radially spread on the facility floor and to perform the sensitivity analysis with respect to the baseline design and operating conditions such as elevation height of the discharge port and fresh grout properties. For the CFD modeling calculations, air-grout Volume of Fluid (VOF) method combined with Bingham plastic and time-dependent grout models were used for examining the impact of fluid spread performance for the initial baseline configurations and to evaluate the impact of grout pouring height on grout quality. The grout quality was estimated in terms of the air volume fraction for the grout layer formed on the SDU6 floor, resulting in the change of grout density. The study results should be considered as preliminary scoping analyses since benchmarking analysis is not included in this task scope. Transient analyses with the Bingham plastic model were performed with the FLUENTTM code on the high performance parallel computing platform in SRNL. The analysis coupled with a transient grout aging model was performed by using ANSYS-CFX code

  18. Levator claviculae muscle presenting as a hard clavicular mass: imaging study

    International Nuclear Information System (INIS)

    Ruiz Santiago, F.; Lopez Milena, G.; Tristan Fernandez, J.M.; Chamorro Santos, C.

    2001-01-01

    We report a case of levator claviculae muscle presenting clinically as a hard mass in the clavicular area due to angular deformity of this bone. To our knowledge, this is the first report where the anomalous muscle shows this clinical presentation. (orig.)

  19. Clinical presentation and visual status of retinitis pigmentosa patients: a multicenter study in southwestern Nigeria.

    Science.gov (United States)

    Onakpoya, Oluwatoyin Helen; Adeoti, Caroline Olufunlayo; Oluleye, Tunji Sunday; Ajayi, Iyiade Adeseye; Majengbasan, Timothy; Olorundare, Olayemi Kolawole

    2016-01-01

    To review the visual status and clinical presentation of patients with retinitis pigmentosa (RP). Multicenter, retrospective, and analytical review was conducted of the visual status and clinical characteristics of patients with RP at first presentation from January 2007 to December 2011. Main outcome measure was the World Health Organization's visual status classification in relation to sex and age at presentation. Data analysis by SPSS (version 15) and statistical significance was assumed at Ppresent in their siblings 15 (71.4%), grandparents 11 (52.3%), and parents 4 (19.4%). Forty (41.7%) were blind at presentation and 23 (24%) were visually impaired. Blindness in six (15%) patients was secondary to glaucoma. Retinal vascular narrowing and retinal pigmentary changes of varying severity were present in all patients. Thirty-five (36.5%) had maculopathy, 36 (37.5%) refractive error, 19 (20%) lenticular opacities, and eleven (11.5%) had glaucoma. RP was typical in 85 patients (88.5%). Older patients had higher rates of blindness at presentation (P=0.005); blindness and visual impairment rate at presentation were higher in males than females (P=0.029). Clinical presentation with advanced diseases, higher blindness rate in older patients, sex-related difference in blindness/visual impairment rates, as well as high glaucoma blindness in RP patients requires urgent attention in southwestern Nigeria.

  20. Present status and prospect of the experimental study of QED in high Z ions

    International Nuclear Information System (INIS)

    Briand, J.P.

    1993-01-01

    I summarize in this paper the present status of our experimental knowledge on the Lamb shift of high Z hydrogenlike ions. Some tentative prospect on the future improvements with the new large accelerators and ion sources are discussed and compared with the present accuracy of QED corrections. (orig.)

  1. Alcohol-related presentations to emergency departments in Ireland: a descriptive prevalence study

    LENUS (Irish Health Repository)

    McNicholl, Brian

    2018-05-24

    To determine the prevalence of alcohol-related presentations in all 29 emergency departments (EDs) in Ireland and compare with non-alcohol-related presentations in order to identify opportunities for improvements in the quality of patient care and related data collection.

  2. Neural processes underlying the"same"-"different" judgment of two simultaneously presented objects--an EEG study.

    Directory of Open Access Journals (Sweden)

    Ruiling Zhang

    Full Text Available The present study investigated the neural processes underlying "same" and -"different" judgments for two simultaneously presented objects, that varied on one or both, of two dimensions: color and shape. Participants judged whether or not the two objects were "same" or "different" on either the color dimension (color task or the shape dimension (shape task. The unattended irrelevant dimension of the objects was either congruent (same-same; different-different or incongruent (same-different. ERP data showed a main effect of color congruency in the time window 190-260 ms post-stimulus presentation and a main effect of shape congruency in the time window 220-280 ms post-stimulus presentation in both color and shape tasks. The interaction between color and shape congruency in the ERP data occurred in a later time window than the two main effects, indicating that mismatches in task-relevant and task-irrelevant dimensions were processed automatically and independently before a response was selected. The fact that the interference of the task-irrelevant dimension occurred after mismatch detection, supports a confluence model of processing.

  3. Benthic boundary layer modelling studies

    International Nuclear Information System (INIS)

    Richards, K.J.

    1984-01-01

    A numerical model has been developed to study the factors which control the height of the benthic boundary layer in the deep ocean and the dispersion of a tracer within and directly above the layer. This report covers tracer clouds of horizontal scales of 10 to 100 km. The dispersion of a tracer has been studied in two ways. Firstly, a number of particles have been introduced into the flow. The trajectories of these particles provide information on dispersion rates. For flow conditions similar to those observed in the abyssal N.E. Atlantic the diffusivity of a tracer was found to be 5 x 10 6 cm 2 s -1 for a tracer within the boundary layer and 8 x 10 6 cm 2 s -1 for a tracer above the boundary layer. The results are in accord with estimates made from current meter measurements. The second method of studying dispersion was to calculate the evolution of individual tracer clouds. Clouds within and above the benthic boundary layer often show quite different behaviour from each other although the general structure of the clouds in the two regions were found to have no significant differences. (author)

  4. Studying Present Dairy Industry Management in the Khorasan Province of Iran

    Directory of Open Access Journals (Sweden)

    R Valizadeh

    2013-11-01

    Full Text Available The present condition and feeds utilization of dairy industry in Khorasan province was studied in 113 dairy farms based on the official data from Ministry of Agricultural-Jehad. Questioners evaluated the required parameters. The percentage proportion of lactating cows, dry cows, pregnant heifers, virgin heifers, 6-12 months old calves, under 6 months and 3 months old calves and breeding bulls were; 39, 10, 11, 6, 15, 9, 10 and 0.1 precent, respectively. Mean of milk yield was 25.5 kg/day with fat content of 3.5%. A large variation was detected in forage quality and concentrate constituents and composition. Generally, difference between feed costs in various seasons was about 30%. All group of cows were offered more nutrients than the recommended levels. The percentage of extra feed cost in comparison with the total dairy cost of feeding was 9.1, 14.3, 15.0 and 9.1 percent for the high, medium and low milk- producing and dry cows. Most of the used concentrates were prepared in the farms. Net energy of lactation (NEL and protein contents of the hand made and factory made concentrates were 1.73±0.03 Mcal per kg dry matter, 16.1±0.8% and 1.68±0.04 Mcal per kg dry matter and 15.3±1.04%, respectively. In most of the farms, silos were non-appropriately made. It was concluded that most of the utilized rations were imbalance in energy and protein ratios. Technical attention must be regarded to the ration formulation and forage quality in the province.

  5. Primary mediastinal melanoma presenting as superior vena cava syndrome: A case study

    Directory of Open Access Journals (Sweden)

    Ann C Gaffey

    2016-03-01

    Full Text Available The rates of melanoma have increased over the past 30 years. Malignant melanoma most commonly occurs in the skin with secondary involvement of other organs. Here, we present an extremely rare case of malignant melanoma of the mediastinum with presentation of superior vena cava syndrome without clinical evidence of extrathoracic disease. The incidence of this clinical presentation is uncommon, resulting in only a handful of case reports in the literature. [Arch Clin Exp Surg 2016; 5(1.000: 56-58

  6. Computerised modelling for developmental biology : an exploration with case studies

    NARCIS (Netherlands)

    Bertens, Laura M.F.

    2012-01-01

    Many studies in developmental biology rely on the construction and analysis of models. This research presents a broad view of modelling approaches for developmental biology, with a focus on computational methods. An overview of modelling techniques is given, followed by several case studies. Using

  7. Background Complex angiographic lesions and clinic presentation in unstable angina. A prospective study

    International Nuclear Information System (INIS)

    LLuberas, R.; Mallo, D.; Pouso, J.; Artucio, C.; Korytnicki; Argon, L.; Besada, E.; Tavella, N.

    2002-01-01

    Background Complex angiography lesions and intracoronary thrombus have been identified in unstable angina.Braunwalds categorization has been accepted in the last years.Identifying severe clinical classes class III (angina at rest during the last 48 hours), class C (angina postinfarction) and class c (angina with maximum therapeutic). The main objective of this study was to determine independent associations of Braunwalds classes III, C and c: complex lesions, intracoronary thrombus, total occlusion and distal flux TIMI<3 of the responsible vessel. The secondary objectives were to analyze the angiographic features of the lesion and the responsible vessel. Aprospective study of 300 patients with diagnosed unstable angina, clustered according to Braunwalds clinis classification was done. The angiographic evaluation was performed identifying the responsible lesion and the presence of the complex lesion, intracoronary thrombus, total occlusion and distal flux TIMI<3 of the responsible vessel. A univariate analysis and a multivariate model of binary logistic regression were used. In the 300 patient population, 22 patients with normal coronaries(7.3%) were identified. The responsible lesion was identified in 243 out of the remaining 278 patients (87,4%). Class III was significantly associated with the complex lesion (OR=2.74, IC95%=1,27-5,9) and intracoronary thrombus (OR=2,82 IC95=1,2-6,6). Class C was significantly associated with intracoronary thrombus (OR=3.9),IC95%=1.53-10,0).Class III was and independent predictor for the presence of the complex lesion(OR=1.98, IC 95%=1,01-3,87) and intracoronary thrombus (OR=2,47 IC95%=1,14-5,37). Class C was and independent predictor for the complex lesion (OR=5,05,IC95%=2.25-11,3), infracoronary thrombus (OR=8,04, IC 95%=3,49-18,0), total occlusion (OR=6,49, IC95%=2,67-15,7) and distal flux TIMI<3(OR=3,96,IC 95%=1,87-8,4) There was no significant association between classes III, C and c and the responsible vessel, localization of

  8. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study.

    Science.gov (United States)

    Stanley, Adrian J; Laine, Loren; Dalton, Harry R; Ngu, Jing H; Schultz, Michael; Abazi, Roseta; Zakko, Liam; Thornton, Susan; Wilkinson, Kelly; Khor, Cristopher J L; Murray, Iain A; Laursen, Stig B

    2017-01-04

     To compare the predictive accuracy and clinical utility of five risk scoring systems in the assessment of patients with upper gastrointestinal bleeding.  International multicentre prospective study.  Six large hospitals in Europe, North America, Asia, and Oceania.  3012 consecutive patients presenting over 12 months with upper gastrointestinal bleeding.  Comparison of pre-endoscopy scores (admission Rockall, AIMS65, and Glasgow Blatchford) and post-endoscopy scores (full Rockall and PNED) for their ability to predict predefined clinical endpoints: a composite endpoint (transfusion, endoscopic treatment, interventional radiology, surgery, or 30 day mortality), endoscopic treatment, 30 day mortality, rebleeding, and length of hospital stay. Optimum score thresholds to identify low risk and high risk patients were determined.  The Glasgow Blatchford score was best (area under the receiver operating characteristic curve (AUROC) 0.86) at predicting intervention or death compared with the full Rockall score (0.70), PNED score (0.69), admission Rockall score (0.66, and AIMS65 score (0.68) (all P<0.001). A Glasgow Blatchford score of ≤1 was the optimum threshold to predict survival without intervention (sensitivity 98.6%, specificity 34.6%). The Glasgow Blatchford score was better at predicting endoscopic treatment (AUROC 0.75) than the AIMS65 (0.62) and admission Rockall scores (0.61) (both P<0.001). A Glasgow Blatchford score of ≥7 was the optimum threshold to predict endoscopic treatment (sensitivity 80%, specificity 57%). The PNED (AUROC 0.77) and AIMS65 scores (0.77) were best at predicting mortality, with both superior to admission Rockall score (0.72) and Glasgow Blatchford score (0.64; P<0.001). Score thresholds of ≥4 for PNED, ≥2 for AIMS65, ≥4 for admission Rockall, and ≥5 for full Rockall were optimal at predicting death, with sensitivities of 65.8-78.6% and specificities of 65.0-65.3%. No score was helpful at predicting rebleeding or length

  9. Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study.

    Science.gov (United States)

    Rojas-Marcos, Iñigo; Graus, Francesc; Sanz, Gema; Robledo, Arturo; Diaz-Espejo, Carlos

    2007-01-01

    We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each hippocampus. Ma2 antibodies were found in the patient's serum, and fiberbronchoscopy disclosed a lung carcinoma. After three months of steroid treatment, the results of the patient's neurological exam became normal. We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer.

  10. Presentation and analysis of radiographic data in clinical trials and observational studies

    NARCIS (Netherlands)

    Landewé, R.; van der Heijde, D.

    2005-01-01

    Despite the advent of sophisticated imaging systems, plain radiography continues to be a valuable outcome variable in clinical trials of inflammatory disorders for a number of reasons. This paper discusses the pros and cons of the different ways in which radiographic data in trials is presented; the

  11. ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

    DEFF Research Database (Denmark)

    Faraco, Juliette; Lin, Ling; Kornum, Birgitte Rahbek

    2013-01-01

    receptor alpha (TRA@), variants in two additional narcolepsy loci, Cathepsin H (CTSH) and Tumor necrosis factor (ligand) superfamily member 4 (TNFSF4, also called OX40L), attained genome-wide significance. These findings underline the importance of antigen presentation by HLA Class II to T cells...

  12. Political Youth Education in Germany. Presenting a Qualitative Study on Its Biographically Long-Term Effects

    Science.gov (United States)

    Balzter, Nadine; Ristau, Yan; Schröder, Achim

    2017-01-01

    Purpose: There is an impact analysis presented, which explores the long-term effect of extra-curricular political youth education from the perspective of participants. Methods: The former participants retell their own education and life stories about five years later. Life stories were then interpreted in the course of research workshops and…

  13. Encountering the Past in the Present: An Exploratory Study of Educational Heritage Tourism

    Science.gov (United States)

    Gross, Magdalena H.; Kelman, Ari Y.

    2017-01-01

    This article presents an educational programme designed to explore the multicultural history of Poland. Targeting Jewish and non-Jewish students of Polish heritage, the "Polonia Programme" (PP) was conceptualised with the aim of applying the tools of experiential education to initiate a new approach to examining one of the world's most…

  14. Clinical presentation of acute Q fever in lanzarote (Canary Islands): a 2-year prospective study.

    Science.gov (United States)

    Pascual Velasco, F; Borobio Enciso, M V; González Lama, Z; Carrascosa Porras, M

    1996-01-01

    The clinical manifestations of acute Q fever may differ markedly from country to country. In this regard, fever and hepatitis seem to be the dominant clinical features of acute Coxiella burnetii infection in Lanzarote, Canary Islands. A possible interaction between environmental factors and some strains of C. burnetii could explain the different clinical presentations of acute Q fever.

  15. Kinetic modelling and characterization of microbial community present in a full-scale UASB reactor treating brewery effluent.

    Science.gov (United States)

    Enitan, Abimbola M; Kumari, Sheena; Swalaha, Feroz M; Adeyemo, J; Ramdhani, Nishani; Bux, Faizal

    2014-02-01

    The performance of a full-scale upflow anaerobic sludge blanket (UASB) reactor treating brewery wastewater was investigated by microbial analysis and kinetic modelling. The microbial community present in the granular sludge was detected using fluorescent in situ hybridization (FISH) and further confirmed using polymerase chain reaction. A group of 16S rRNA based fluorescent probes and primers targeting Archaea and Eubacteria were selected for microbial analysis. FISH results indicated the presence and dominance of a significant amount of Eubacteria and diverse group of methanogenic Archaea belonging to the order Methanococcales, Methanobacteriales, and Methanomicrobiales within in the UASB reactor. The influent brewery wastewater had a relatively high amount of volatile fatty acids chemical oxygen demand (COD), 2005 mg/l and the final COD concentration of the reactor was 457 mg/l. The biogas analysis showed 60-69% of methane, confirming the presence and activities of methanogens within the reactor. Biokinetics of the degradable organic substrate present in the brewery wastewater was further explored using Stover and Kincannon kinetic model, with the aim of predicting the final effluent quality. The maximum utilization rate constant U max and the saturation constant (K(B)) in the model were estimated as 18.51 and 13.64 g/l/day, respectively. The model showed an excellent fit between the predicted and the observed effluent COD concentrations. Applicability of this model to predict the effluent quality of the UASB reactor treating brewery wastewater was evident from the regression analysis (R(2) = 0.957) which could be used for optimizing the reactor performance.

  16. STUDYING OF EARLY CHILDHOOD EDUCATION DEVELOPMENT IN THE TIMES OF UNR BY MEANS OF ELECTRONIC PRESENTATION

    Directory of Open Access Journals (Sweden)

    L.V. Artemova

    2014-04-01

    Full Text Available Development of the students’ competences which consist of the three main groups (general, instrumental, interpersonal provides education of high quality. The instrumental one means “computer skills and information management abilities”. That is the reason why pedagogical staff and students have to master information technologies on the appropriate level. Structural and methodological peculiarities of e-presentations usage on “Early Childhood Education Development in the Times of UNR” topic at lectures, seminars and students’ individual work are considered in the article. The represented methodology of e-presentations usage supplies interactive educational activities of students and teachers. It is considered as a complex of different tasks. It promotes cognitive activities, encourages interest for mastering the content, directs students to use active methods of teaching.

  17. Study of compulsive buying in patients presenting obsessive-compulsive disorder.

    Science.gov (United States)

    Lejoyeux, Michel; Bailly, Florence; Moula, Hervé; Loi, Sabrina; Adès, Jean

    2005-01-01

    The authors assessed the prevalence of compulsive buying (CB) among patients presenting an obsessive-compulsive disorder (OCD). They compared the buying style of patients with and without CB. One thousand five hundred consecutive patients were assessed by a general practitioner in Paris (France). Sixty patients presenting with OCD were included. Patients with CB associated with OCD (n = 14) were compared with those with "pure" OCD (n = 46). Sixty patients paired for sex and age and free from OCD, depression, and anxiety were also recruited among the clients of the same general practitioner. We compared 3 groups: controls, patients with OCD, and patients with OCD + CB. Prevalence of CB was 23% (14 cases) among patients with OCD and 6% (4 cases) in controls (chi(2)(1) = 5.3, P = .02). Patients presenting with OCD + CB had a higher number of Diagnostic and Statistical Manual of Mental Disorders, Revised Fourth Edition diagnostic criteria for OCD than patients with pure OCD (6.1 and 5.4, respectively, P = .001). Depression was more frequent in the OCD + CB group (78%) than in the OCD group (42%) and in controls (10%) (P = .02). Patients from the OCD + CB group had higher score at the CAGE questionnaire than those of the OCD group (2 vs 0.7, P = .003). Patients with OCD + CB considered 42% of their purchases as occasions not to be passed up compared with 15.4% in the OCD group and 8.6% in controls. OCD+CD patients used the items they bought after a longer delay than controls and patients with pure OCD (8.2 vs 3 and 3.1 days, respectively). Compulsive buying is more frequent in OCD than in controls. Patients presenting with OCD + CB show more depressive disorders and drink more alcohol. They are more highly implicated in the items they buy and they are more often disappointed by the items once they possess them.

  18. Feline asthma syndrome: a retrospective study of the clinical presentation in 29 cats

    International Nuclear Information System (INIS)

    Corcoran, B.M.; Foster, D.J.; Fuentes, V.L.

    1995-01-01

    Feline asthma syndrome (FAS) is a clinical condition characterised by recurrent bouts of coughing, wheezing and, or, dyspnoea. While the aetiology is unproven, the condition is believed to involve a type I immediate hypersensitivity reaction to inhaled allergens. In this paper the clinical data from 29 cats, where a diagnosis of FAS was made, are assessed retrospectively. The most common clinical presentation was recurrent bouts of coughing (n = 26) and dyspnoea (n = 21). Radiographic changes were noted in 24 cats, which included increased bronchial (n = 5), interstitial (n = 7) and mixed (n = 12) (bronchial and interstitial) patterns. Right middle lung lobe collapse was noted in two cats. Abnormal bronchial cytology was present in 16 cats. A predominant eosinophilic sample was collected in only three cats. There were minimal changes in differential white cell counts, and mild eosinophilia was found in only five cats. Prednisolone alone was the most effective therapy, although avoidance of putative aeroallergens and antibacterial therapy was effective in some. On the basis of the data from these cases it would appear that the diagnosis of FAS depends largely on the clinical presentation and radiographic findings. The value of ancillary tests in the diagnosis of FAS appears to be limited

  19. The Role of Presented Objects in Deriving Color Preference Criteria from Psychophysical Studies

    Energy Technology Data Exchange (ETDEWEB)

    Royer, Michael P.; Wei, Minchen

    2016-12-08

    Of the many “components” of a color rendering measure, one is perhaps the most important: the set of color samples (spectral reflectance functions) that are employed as a standardized means of evaluating and rating a light source. At the same time, a standardized set of color samples can never apply perfectly to a real space or a real set of observed objects, meaning there will always be some level of mismatch between the predicted and observed color shifts. This mismatch is important for lighting specifiers to consider, but even more critical for experiments that seek to evaluate the relationship between color rendering measures and human perception. This article explores how the color distortions of three possible experimental object sets compare to the color distortions predicted using the color evaluation samples of IES TM-30-15 (TM-30). The experimental object sets include those from Royer and colleagues [2016], a set of produce (10 fruits and vegetables), and the X-rite Color Checker Classic. The differences are traced back to properties of the samples sets, such as the coverage of color space, average chroma level, and specific spectral features. The consequence of the differences, that the visual evaluation is based on color distortions that are substantially different from what is predicted, can lead to inaccurate criteria or models of a given perception, such as preference. To minimize the error in using criteria or models when specifying color rendering attributes for a given application, the criteria or models should be developed using a set of experimental objects that matches the typical objects of the application as closely as possible. Alternatively, if typical objects of an application cannot be reasonably determined, an object set that matches the distortions predicted by TM-30 as close as possible is likely to provide the most meaningful results.

  20. Phytochemical analysis and docking study of compounds present in a polyherbal preparation used in the treatment of dermatophytosis.

    Science.gov (United States)

    Simhadri Vsdna, Nagesh; Muniappan, Muthuchamy; Kannan, Iyanar; Viswanathan, Subramanyam

    2017-12-01

    Soleshine is a polyherbal preparation established in the market for the treatment of cracks and tinea pedis, which is applied externally. This preparation is composed of the extracts of indigenous plants, namely Azadirachta indica, Lawsonia alba, and Shorea robusta , mixed with castor oil and sesame oil. In the present study, an attempt was made to identify the constituents of soleshine and identify some potential drug-like molecules that can inhibit important drug targets of the dermatophytes using molecular docking method. The active ingredients of polyherbal preparation were identified with the aid of gas chromatography-mass spectrometry (GC-MS). Two major compounds were selected based on the retention time and percentage of the area covered in the graph for docking study. The three-dimensional structures of 1,3-β-glucan synthase, chitinase, fungalysin, and lumazine synthase were derived by homology modelling using MODELLER software, version 9.0. The docking of the ligand and receptor was performed using iGEMDOCK and AutodockVina software. The physicochemical properties, lipophilicity, hydrophilicity, and drug likeness properties were obtained from the Swiss ADME online server tool. The GC-MS analysis demonstrated the presence of different phytochemical compounds in the extract of polyherbal preparation. A total of 20 compounds were identified, among which 3,7-dimethyl-2,6-octadienaland 2-pentene-2-methyl were the major compounds. Regarding 3,7-dimethyl-2,6-octadienal, the covered area and height were 40.15% and 46.17%, respectively. These values were 31.90% and 23.33% for 2-pentene-2-methyl, respectively. These two major compounds had an excellent binding affinity and obeyed the rules for the drug likeness and lead likeness. As the findings indicated, the two major ingredients present in soleshine showed a good antifungal activity as they inhibited the enzymes responsible for the survival of fungal organism; furthermore, they were appropriate for the lead

  1. Study on computerized presentation of emergency procedures of a nuclear plant (step 2). The guidelines of the prototype of the computerized procedure presentation system

    International Nuclear Information System (INIS)

    Niwa, Yuji; Hollnagel, E.; Iwaki, Toshio.

    1995-01-01

    New methods of information presentation and interface design are changing the working conditions in the modern Nuclear Power Plant (NPP) control room. One area receiving considerable attention is that of Emergency Operating Procedures (EOPs), which plays an essential role in NPPs. Conventionally procedures are presented in a hard copy form. However developments in information technology have offered new opportunities for the computerization of such procedures. Consideration for the first stage of computerization should be focused upon the presentation of procedures. The specification of the computerized presentation of procedures is discussed with respect to the issues which were central to the project: navigation through procedures; formatting and presentation of procedures; and process monitoring. Issues that would be included in more advanced systems, such as help and explanation facilities features, and process linking, are also discussed. This paper deals with the specific design guidelines that were implemented for the computerization of procedure presentation. Issues of principal concern that were identified from this experience are highlighted, such as the relationship between procedure presentation and format; the registration of progress through a procedure; compensation for the limitations of computer displays versus printed documents; and the way in which the added capabilities of computerized presentation can be generally utilized in the operators' working environment. (author)

  2. Teaching Business French through Case Studies: Presentation of a Marketing Case.

    Science.gov (United States)

    Federico, Salvatore; Moore, Catherine

    The use of case studies as a means for teaching business French is discussed. The approach is advocated because of the realism of case studies, which are based on actual occurrences. Characteristics of a good case are noted: it tells a story, focuses on interest-arousing issues, is set in the past 10 years, permits empathy with the main…

  3. A descriptive study of women presenting to an obstetric triage unit with no prenatal care.

    Science.gov (United States)

    Knight, Erin; Morris, Margaret; Heaman, Maureen

    2014-03-01

    To describe women presenting to an obstetric triage unit with no prenatal care (PNC), to identify gaps in care, and to compare care provided to World Health Organization (WHO) standards. We reviewed the charts of women who gave birth at Women's Hospital in Winnipeg and were discharged between April 1, 2008, and March 31, 2011, and identified those whose charts were coded with ICD-10 code Z35.3 (inadequate PNC) or who had fewer than 2 PNC visits. Three hundred eighty-two charts were identified, and sociodemographic characteristics, PNC history, investigations, and pregnancy outcomes were recorded. The care provided was compared with WHO guidelines. One hundred nine women presented to the obstetric triage unit with no PNC; 96 (88.1%) were in the third trimester. Only 39 women (35.8%) received subsequent PNC, with care falling short of WHO standards. Gaps in PNC included missing time-sensitive screening tests, mid-stream urine culture, and Chlamydia and gonorrhea testing. The mean maternal age was 26.1 years, and 93 women (85.3%) were multigravidas. More than one half of the women (51.4%) were involved with Child and Family Services, 64.2% smoked, 33.0% drank alcohol, and 32.1% used illicit drugs during pregnancy. Two thirds of the women (66.2%) lived in inner-city Winnipeg. Only 63.0% of neonates showed growth appropriate for gestational age. Two pregnancies ended in stillbirth; there was one neonatal death, and over one third of the births were preterm. Most women who present with no PNC do so late in pregnancy, proceed to deliver with little or no additional PNC, and have high rates of adverse outcomes. Thus, efforts to improve PNC must focus on facilitating earlier entry into care. This would also improve compliance with WHO guidelines for continuing care. Treatment protocols could improve gaps in obtaining urine culture and in Chlamydia and gonorrhea testing.

  4. Mathematical modelling a case studies approach

    CERN Document Server

    Illner, Reinhard; McCollum, Samantha; Roode, Thea van

    2004-01-01

    Mathematical modelling is a subject without boundaries. It is the means by which mathematics becomes useful to virtually any subject. Moreover, modelling has been and continues to be a driving force for the development of mathematics itself. This book explains the process of modelling real situations to obtain mathematical problems that can be analyzed, thus solving the original problem. The presentation is in the form of case studies, which are developed much as they would be in true applications. In many cases, an initial model is created, then modified along the way. Some cases are familiar, such as the evaluation of an annuity. Others are unique, such as the fascinating situation in which an engineer, armed only with a slide rule, had 24 hours to compute whether a valve would hold when a temporary rock plug was removed from a water tunnel. Each chapter ends with a set of exercises and some suggestions for class projects. Some projects are extensive, as with the explorations of the predator-prey model; oth...

  5. Plasma simulation studies using multilevel physics models

    International Nuclear Information System (INIS)

    Park, W.; Belova, E.V.; Fu, G.Y.; Tang, X.Z.; Strauss, H.R.; Sugiyama, L.E.

    1999-01-01

    The question of how to proceed toward ever more realistic plasma simulation studies using ever increasing computing power is addressed. The answer presented here is the M3D (Multilevel 3D) project, which has developed a code package with a hierarchy of physics levels that resolve increasingly complete subsets of phase-spaces and are thus increasingly more realistic. The rationale for the multilevel physics models is given. Each physics level is described and examples of its application are given. The existing physics levels are fluid models (3D configuration space), namely magnetohydrodynamic (MHD) and two-fluids; and hybrid models, namely gyrokinetic-energetic-particle/MHD (5D energetic particle phase-space), gyrokinetic-particle-ion/fluid-electron (5D ion phase-space), and full-kinetic-particle-ion/fluid-electron level (6D ion phase-space). Resolving electron phase-space (5D or 6D) remains a future project. Phase-space-fluid models are not used in favor of δf particle models. A practical and accurate nonlinear fluid closure for noncollisional plasmas seems not likely in the near future. copyright 1999 American Institute of Physics

  6. Plasma simulation studies using multilevel physics models

    International Nuclear Information System (INIS)

    Park, W.; Belova, E.V.; Fu, G.Y.

    2000-01-01

    The question of how to proceed toward ever more realistic plasma simulation studies using ever increasing computing power is addressed. The answer presented here is the M3D (Multilevel 3D) project, which has developed a code package with a hierarchy of physics levels that resolve increasingly complete subsets of phase-spaces and are thus increasingly more realistic. The rationale for the multilevel physics models is given. Each physics level is described and examples of its application are given. The existing physics levels are fluid models (3D configuration space), namely magnetohydrodynamic (MHD) and two-fluids; and hybrid models, namely gyrokinetic-energetic-particle/MHD (5D energetic particle phase-space), gyrokinetic-particle-ion/fluid-electron (5D ion phase-space), and full-kinetic-particle-ion/fluid-electron level (6D ion phase-space). Resolving electron phase-space (5D or 6D) remains a future project. Phase-space-fluid models are not used in favor of delta f particle models. A practical and accurate nonlinear fluid closure for noncollisional plasmas seems not likely in the near future

  7. [Discussion on present situation of study on pesticide residues in Chinese herbal medicines].

    Science.gov (United States)

    Kang, Chuan-Zhi; Guo, Lan-Ping; Zhou, Tao; Zhao, Dan; Kang, Li-Ping; He, Ya-Li; Wang, Sheng; Zhou, Liang-Yun

    2016-01-01

    Pesticide residues in traditional Chinese medicine has attracted widespread attention at home and abroad. This paper analyzed the pollution present situation and existing problems of pesticide residue for Chinese herbal medicines, explicited the analytical methods of pesticide residues in Chinese herbal medicines. Meanwhile, the commonly used pesticide residue degradation and application in Chinese herbal medicines were discussed. Moreover, on the basis of analysis of pesticide residue standards, this paper proposed the necessity and urgency of the limit standard of pesticide residues in Chinese herbal medicines, and provided a scientific references for deepening research and developing safe, green medicines. Copyright© by the Chinese Pharmaceutical Association.

  8. Huntington disease: a case study of early onset presenting as depression.

    Science.gov (United States)

    Duesterhus, Pia; Schimmelmann, Benno Graf; Wittkugel, Oliver; Schulte-Markwort, Michael

    2004-10-01

    Huntington disease is a dominantly inherited, neurodegenerative disease characterized by choreiform movement disturbances and dementia, usually with adult onset. The rare juvenile-onset Huntington disease differs from the adult phenotype. A case presenting twice, at age 10 with all the signs of a major depression and age 14 with mutism and rigidity, is reported. Meanwhile, the father developed the adult variant of Huntington disease. The boy's diagnosis was confirmed by molecular genetic analysis and magnetic resonance imaging. It is important to be aware of hereditary conditions such as Huntington disease and to provide family counseling before genetic testing and after the diagnosis is confirmed.

  9. Present status of VDEs (Vertical Displacement Events) avoidance studies in tokamak disruptions

    International Nuclear Information System (INIS)

    Nakamura, Yukiharu

    2001-01-01

    Present knowledge on the consequences of tokamak disruption and disruption-related effects are reviewed from a viewpoint of disruption mitigation and/or avoidance. The Vertical Displacement Events (VDEs), which are frequently observed in disruptive discharges of elongated tokamaks, are described in detail with an emphasis on the close relationships between the generation of halo currents and runaway electrons. The newly found 'neutral point', at which VDEs hardly occur, is also addressed. Finally, VDE-related issues remaining to be addressed in future works are discussed. (author)

  10. Thermogravimetric study of reduction of oxides present in oxidized nickel-base alloy powders

    Science.gov (United States)

    Herbell, T. P.

    1976-01-01

    Carbon, hydrogen, and hydrogen plus carbon reduction of three oxidized nickel-base alloy powders (a solid solution strengthened alloy both with and without the gamma prime formers aluminum and titanium and the solid solution strengthened alloy NiCrAlY) were evaluated by thermogravimetry. Hydrogen and hydrogen plus carbon were completely effective in reducing an alloy containing chromium, columbium, tantalum, molybdenum, and tungsten. However, with aluminum and titanium present the reduction was limited to a weight loss of about 81 percent. Carbon alone was not effective in reducing any of the alloys, and none of the reducing conditions were effective for use with NiCrAlY.

  11. Mathematical Modelling Research in Turkey: A Content Analysis Study

    Science.gov (United States)

    Çelik, H. Coskun

    2017-01-01

    The aim of the present study was to examine the mathematical modelling studies done between 2004 and 2015 in Turkey and to reveal their tendencies. Forty-nine studies were selected using purposeful sampling based on the term, "mathematical modelling" with Higher Education Academic Search Engine. They were analyzed with content analysis.…

  12. Fallout model for system studies

    International Nuclear Information System (INIS)

    Harvey, T.F.; Serduke, F.J.D.

    1979-01-01

    A versatile fallout model was developed to assess complex civil defense and military effect issues. Large technical and scenario uncertainties require a fast, adaptable, time-dependent model to obtain technically defensible fallout results in complex demographic scenarios. The KDFOC2 capability, coupled with other data bases, provides the essential tools to consider tradeoffs between various plans and features in different nuclear scenarios and estimate the technical uncertainties in the predictions. All available data were used to validate the model. In many ways, the capability is unmatched in its ability to predict fallout hazards to a society

  13. A mathematical model of the rail track presented as a bar on elastic and dissipative supports under the influence of moving loads

    Directory of Open Access Journals (Sweden)

    Darenskiy Alexander

    2017-01-01

    Full Text Available At present, the most common track model is the one in which rails are presented as bars of infinite length rested on continuous elastic foundation. However, some specialists consider the model to be rather ideal for railways in terms of track and the technical state of track. Calculation of track as a bar rested on numerous elastic supports with variable characteristics of stiffness under static loads has shown that application of methods of elastic foundation gives results understated by 17-24%. The study presents mathematic models of the vehicle/track dynamic system, and a design scheme of track presented as a bar on numerous elastic dissipative supports with non-linear characteristics, which is taken on the base of this system. The authors developed models and methods to define the reduced vertical stiffness of the track in the wheel/rail contact point, which considers rail elastic and geometric characteristics, stiffness of supports, distance between supports and distributed track mass. The value of stiffness is variable by time for each wheel at any time and various for the vehicle’s wheels. The mathematical model proposed has been implemented in Matlab software and will make it possible to conduct numerical research into the track/vehicle dynamics.

  14. Analysis and study of spent fuel reprocessing technology from birth to present

    International Nuclear Information System (INIS)

    Takahashi, Keizo

    2006-01-01

    As for the nuclear fuel reprocessing of the spent fuel, although there was argument of pros and cons, it was decided to start Rokkasho reprocessing project further at the Japan Atomic Energy Commission of ''Long-Term Program for Research, Development and Utilization of Nuclear Energy'' in year 2004. The operation of Tokai Reprocessing is going steadily to reprocess spent fuel more than 1,100 tons. In this paper, history, present status and future of reprocessing technology is discussed focusing from military Pu production, Magnox fuel reprocessing to oxide fuel reprocessing. Amount of reprocessed fuel are estimated based on fuel type. Then, history of reprocessing, US, UK, France, Germany, Russian, Belgian and Japan is presented and compared on technology, national character, development organization, environmental protection, and high active waste vitrification. Technical requirements are increased from Pu production fuel, Magnox fuel and oxide fuel mainly because of higher burnup. Reprocessing technology is synthetic of engineering and accumulation of operational experience. The lessons learned from the operational experience of the world will be helpful for establishment of nuclear fuel reprocessing technology in Japan. (author)

  15. A solitary bronchial papilloma with unusual endoscopic presentation: case study and literature review

    Directory of Open Access Journals (Sweden)

    Frejeville Marie

    2009-08-01

    Full Text Available Abstract Background Solitary endobronchial papillomas (SEP are rare tumors and most of them are described by case report. A misdiagnosis is common with viral related papillomas. A histopathological classification has recently permitted a major advancement in the understanding of the disease. Case Presentation We report a case of a mixed bronchial papilloma with an unusual endoscopic presentation. The literature was extensively reviewed to ascertain the unusual characteristics of the current case. A 39-year of age male was referred to our institution for the investigation of a slight hemoptysis. Routine examination was normal. A fibroscopy revealed an unusual feature of the right main bronchus. The lesion was a plane, non-bleeding, non-glistering sub-mucosal proliferation. No enhanced coloration was noticed. Biopsies revealed a mixed solitary bronchial papilloma. In situ HPV hybridization was negative. Endoscopic treatment (electrocautery was effective with no relapse. Conclusion This lesion contrasts with the data of the literature where papilloma were described as wart-like lesions or cauliflower tumors, with symptoms generally related to bronchial obstruction. We advise chest physicians to be cautious with unusually small swollen lesions of the bronchi that may reveal a solitary bronchial papilloma. Endoscopic imaging can significantly contribute to the difficult diagnosis of SEP by pulmonary physicians and endoscopists.

  16. Increased prostate cancer specific mortality following radical prostatectomy in men presenting with voiding symptoms-A whole of population study.

    Science.gov (United States)

    Ta, Anthony D; Papa, Nathan P; Lawrentschuk, Nathan; Millar, Jeremy L; Syme, Rodney; Giles, Graham G; Bolton, Damien M

    2015-09-01

    Whole of population studies reporting long-term outcomes following radical prostatectomy (RP) are scarce. We aimed to evaluate the long-term outcomes in men with prostate cancer (PC) treated with RP in a whole of population cohort. A secondary objective was to evaluate the influence of mode of presentation on PC specific mortality (PCSM). A prospective database of all cases of RP performed in Victoria, Australia between 1995 and 2000 was established within the Victorian Cancer Registry. Specimen histopathology reports and prostate-specific antigen (PSA) values were obtained by record linkage to pathology laboratories. Mode of presentation was recorded as either PSA screened (PSA testing offered in absence of voiding symptoms) or symptomatic (diagnosis of PC following presentation with voiding symptoms). Multivariate Cox and competing risk regression models were fitted to analyze all-cause mortality, biochemical recurrence, and PCSM. Between 1995 and 2000, 2,154 men underwent RP in Victoria. During median follow up of 10.2 years (range 0.26-13.5 years), 74 men died from PC. In addition to Gleason score and pathological stage, symptomatic presentation was associated with PCSM. After adjusting for stage and PSA, no difference in PCSM was found between men with Gleason score ≤ 6 and Gleason score 3 + 4 = 7. Men with Gleason score 4 + 3 had significantly greater cumulative incidence of PCSM compared with men with Gleason score 3 + 4. Primary Gleason pattern in Gleason 7 PC is an important prognosticator of survival. Our findings suggest that concomitant voiding symptoms should be considered in the work-up and treatment of PC.

  17. Modelling present-day basal melt rates for Antarctic ice shelves using a parametrization of buoyant meltwater plumes

    Science.gov (United States)

    Lazeroms, Werner M. J.; Jenkins, Adrian; Hilmar Gudmundsson, G.; van de Wal, Roderik S. W.

    2018-01-01

    Basal melting below ice shelves is a major factor in mass loss from the Antarctic Ice Sheet, which can contribute significantly to possible future sea-level rise. Therefore, it is important to have an adequate description of the basal melt rates for use in ice-dynamical models. Most current ice models use rather simple parametrizations based on the local balance of heat between ice and ocean. In this work, however, we use a recently derived parametrization of the melt rates based on a buoyant meltwater plume travelling upward beneath an ice shelf. This plume parametrization combines a non-linear ocean temperature sensitivity with an inherent geometry dependence, which is mainly described by the grounding-line depth and the local slope of the ice-shelf base. For the first time, this type of parametrization is evaluated on a two-dimensional grid covering the entire Antarctic continent. In order to apply the essentially one-dimensional parametrization to realistic ice-shelf geometries, we present an algorithm that determines effective values for the grounding-line depth and basal slope in any point beneath an ice shelf. Furthermore, since detailed knowledge of temperatures and circulation patterns in the ice-shelf cavities is sparse or absent, we construct an effective ocean temperature field from observational data with the purpose of matching (area-averaged) melt rates from the model with observed present-day melt rates. Our results qualitatively replicate large-scale observed features in basal melt rates around Antarctica, not only in terms of average values, but also in terms of the spatial pattern, with high melt rates typically occurring near the grounding line. The plume parametrization and the effective temperature field presented here are therefore promising tools for future simulations of the Antarctic Ice Sheet requiring a more realistic oceanic forcing.

  18. Quasi-experimental study designs series-paper 10: synthesizing evidence for effects collected from quasi-experimental studies presents surmountable challenges.

    Science.gov (United States)

    Becker, Betsy Jane; Aloe, Ariel M; Duvendack, Maren; Stanley, T D; Valentine, Jeffrey C; Fretheim, Atle; Tugwell, Peter

    2017-09-01

    To outline issues of importance to analytic approaches to the synthesis of quasi-experiments (QEs) and to provide a statistical model for use in analysis. We drew on studies of statistics, epidemiology, and social-science methodology to outline methods for synthesis of QE studies. The design and conduct of QEs, effect sizes from QEs, and moderator variables for the analysis of those effect sizes were discussed. Biases, confounding, design complexities, and comparisons across designs offer serious challenges to syntheses of QEs. Key components of meta-analyses of QEs were identified, including the aspects of QE study design to be coded and analyzed. Of utmost importance are the design and statistical controls implemented in the QEs. Such controls and any potential sources of bias and confounding must be modeled in analyses, along with aspects of the interventions and populations studied. Because of such controls, effect sizes from QEs are more complex than those from randomized experiments. A statistical meta-regression model that incorporates important features of the QEs under review was presented. Meta-analyses of QEs provide particular challenges, but thorough coding of intervention characteristics and study methods, along with careful analysis, should allow for sound inferences. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. ImmunoChip study implicates antigen presentation to T cells in narcolepsy.

    Directory of Open Access Journals (Sweden)

    Juliette Faraco

    Full Text Available Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip. Three loci located outside the Human Leukocyte Antigen (HLA region on chromosome 6 were significantly associated with disease risk. In addition to a strong signal in the T cell receptor alpha (TRA@, variants in two additional narcolepsy loci, Cathepsin H (CTSH and Tumor necrosis factor (ligand superfamily member 4 (TNFSF4, also called OX40L, attained genome-wide significance. These findings underline the importance of antigen presentation by HLA Class II to T cells in the pathophysiology of this autoimmune disease.

  20. Experimental and modelling studies of infiltration

    International Nuclear Information System (INIS)

    Giudici, M.

    2004-01-01

    This presentation describes a study of infiltration in the unsaturated soil with the objective of estimating the recharge to a phreatic aquifer. The study area is at the border of the city of Milan (Northern Italy), which draws water for both domestic and industrial purposes from ground water resources located beneath the urban area. The rate of water pumping from the aquifer system has been varying during the XX century, depending upon the number of inhabitants and the development of industrial activities. This caused variations with time of the depth of the water table below the ground surface and in turn some emergencies: the two most prominent episodes correspond to the middle '70s, when the water table in the city centre was about 30 m below the undisturbed natural conditions, and to the last decade, when the water table has raised at a rate of approximately 1 m/year and caused infiltrations in deep constructions (garages and building foundations, the underground railways, etc.). We have developed four ground water flow models at different scales, which share some characteristics: they are based on quasi-3D approximation (horizontal flow in the aquifers and vertical flow in the aquitards), conservative finite-differences schemes for regular grid with square cells in the horizontal plane and are implemented with proprietary computer codes. Among the problems that were studied for the development of these models, I recall some numerical problems, related to the behaviour of the phreatic aquifer under conditions of strong exploitation. Model calibration and validation for ModMil has been performed with a two-stage process, i.e., using some of the available data for model calibration and the remaining data for model validation. The application of geophysical exploration techniques, in particular seismic and geo-electrical prospecting, has been very useful to complete the data and information on the hydro-geological structure obtained from stratigraphic logs

  1. A Comparative Study of Video Presentation Modes in Relation to L2 Listening Success

    Science.gov (United States)

    Li, Chen-Hong

    2016-01-01

    Video comprehension involves interpreting both sounds and images. Research has shown that processing an aural text with relevant pictorial information effectively enhances second/foreign language (L2) listening comprehension. A hypothesis underlying this mixed-methods study is that a visual-only silent film used as an advance organiser to activate…

  2. A dual use case study of space technologies for terrestrial medical applications (Conference Presentation)

    Science.gov (United States)

    Cozmuta, Ioana

    2017-05-01

    Many challenges exist in understanding the human body as a whole, its adaptability, its resilience, its immunological response, its healing and regeneration power. New knowledge is usually obtained by exploring unique conditions and environments and space is one such variable. Primarily, these attributes have been studied in space for the purpose of understanding the effect of the space environment on long duration space travel. However a myriad of lessons learned have emerged that are important for terrestrial medicine problems such as cardiovascular changes, intracranial pressure changes, vision changes, reduced immunity, etc. For medical study purposes, the changes induced by the space environment on the human body are in general fast and predictable; they persist while in the space environment but also revert to the initial pre-flight healthy state upon return to Earth. This provides a unique cycle to study wellness and disease prediction as well as to develop more effective countermeasures for the benefit of people on earth. At a scientific level, the environment of space can be used to develop new lines of investigations and new knowledge to push the terrestrial state of the art (i.e. study of phase diagrams, identification of new system's states, etc). Moreover, the specialized requirements for space medicine have driven advances in terrestrial medical technologies in areas such as monitoring, diagnostic, prevention and treatment. This talk will provide an overview of compelling examples in key areas of interest for terrestrial medical applications.

  3. Study on the present and future training of managers and operators for reactor facilities

    International Nuclear Information System (INIS)

    Hagemann, G.; Preuss, W.; Tietze, A.; Wuest, S.

    1973-09-01

    The study gives a survey on the training methods for the operating personnel of reactors in operation or under construction in the FRG and compares them with the training and testing methods of other countries, in particular the USA. (RW/AK) [de

  4. American College Students Studying Abroad in China: Language, Identity, and Self-Presentation

    Science.gov (United States)

    Du, Hang

    2015-01-01

    This article reports the results of qualitative analyses of data drawn from monthly informal individual interviews of 29 American college students who were spending one semester studying Mandarin Chinese abroad in a program in China. While some data confirm previous findings that some students' identification as Americans was strengthened during…

  5. Review on the present status of the German Risk Study: overall results

    International Nuclear Information System (INIS)

    Heuser, F.W.

    1982-01-01

    An overview on the most important results of the German Risk Study (Phase A) is given. Besides plant design analysis, the description mainly refers to core melt accidents, radioactive release and accidental consequences depending on various types of containment failure. Thereby some differences or results compared to WASH 1400 are discussed

  6. Review on the present status of the German Risk Study: plant design analysis

    International Nuclear Information System (INIS)

    Hoertner, H.

    1982-01-01

    The influences of the plant design on the core melt accidents and the corresponding release categories are discussed. The assessed frequencies are compared with the relative figures evaluated by WASH-1400. Additional investigations which are planned or already underway in the Phase B of the German Risk Study are mentioned

  7. Counseling a Student Presenting Borderline Personality Disorder in the Small College Context: Case Study and Implications

    Science.gov (United States)

    Draper, Matthew R.; Faulkner, Ginger E.

    2009-01-01

    This case study examines the dynamics and challenges associated with counseling a client experiencing borderline personality disorder in the small college institutional context. The work of counseling centers at small private institutions has been relatively unexplored in the extant college counseling literature. To help fill this gap, the current…

  8. Gender Equality in Media Content and Operations: Articulating Academic Studies and Policy--A Presentation

    Science.gov (United States)

    Lourenço, Mirta Edith

    2016-01-01

    In this article, Mirta Lourenço explains the prospects when higher education studies interface with UNESCO for policy change. The baseline is that education institutions' articulation with media organizations, media professionals, policy-makers, and civil society groups is essential to achieve gender equality in and through media.

  9. Evaluation of biases present in the cohort multiple randomised controlled trial design : a simulation study

    NARCIS (Netherlands)

    Candlish, Jane; Pate, Alexander; Sperrin, Matthew; Staa, Tjeerd P van

    2017-01-01

    BACKGROUND: The cohort multiple randomised controlled trial (cmRCT) design provides an opportunity to incorporate the benefits of randomisation within clinical practice; thus reducing costs, integrating electronic healthcare records, and improving external validity. This study aims to address a key

  10. Publication rate of studies presented at veterinary anaesthesia specialty meetings during the years 2003-2008.

    Science.gov (United States)

    Wieser, Marilies; Braun, Christina; Moens, Yves

    2016-03-01

    To assess publication rates, factors predicting publication, and discrepancies between conference abstracts and subsequent full-text publications of abstracts from the veterinary meetings of the American College of Veterinary Anesthesiologists and the Association of Veterinary Anaesthetists from 2003 to 2008. Retrospective cohort study. A total of 607 abstracts were identified and a database search (Scopus, PubMed, CAB) was conducted to identify matching publications. Authors of nonmatching abstracts were contacted to participate in a confidential online survey. Risk ratios were used to assess factors predicting publication and these were tested for significance (p publication rate was 63.3% and the mean (± SD) time to publication was 25 ± 19 months. Factors significantly associated with subsequent full publication (i.e. publication of a full manuscript in a peer-reviewed journal) were continent of origin (North America), study design (experimental studies), specialty (analgesia) and the presence of a source of funding. The principal reasons why studies remained unpublished were lack of time and responsibility lying with co-authors. Minor changes compared with the original abstract were found in 71.6% of all publications. Major changes were noted in 34.6% and the outcome of the study changed in 7.6%. These data suggest that some of the abstracts reported preliminary findings. Therefore, caution is warranted when quoting abstracts as references in scientific publications. To date, major veterinary journals have not issued recommendations in their author guidelines addressing the use of abstracts as a reference. The authors propose the inclusion of such a statement in author guidelines. © 2015 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  11. Salt intrusion study in Cochin estuary - Using empirical models

    Digital Repository Service at National Institute of Oceanography (India)

    Jacob, B.; Revichandran, C.; NaveenKumar, K.R.

    been applied to the Cochin estuary in the present study to identify the most suitable model for predicting the salt intrusion length. Comparison of the obtained results indicate that the model of Van der Burgh (1972) is the most suitable empirical model...

  12. Past, present and future distributions of an Iberian Endemic, Lepus granatensis: ecological and evolutionary clues from species distribution models.

    Directory of Open Access Journals (Sweden)

    Pelayo Acevedo

    Full Text Available The application of species distribution models (SDMs in ecology and conservation biology is increasing and assuming an important role, mainly because they can be used to hindcast past and predict current and future species distributions. However, the accuracy of SDMs depends on the quality of the data and on appropriate theoretical frameworks. In this study, comprehensive data on the current distribution of the Iberian hare (Lepus granatensis were used to i determine the species' ecogeographical constraints, ii hindcast a climatic model for the last glacial maximum (LGM, relating it to inferences derived from molecular studies, and iii calibrate a model to assess the species future distribution trends (up to 2080. Our results showed that the climatic factor (in its pure effect and when it is combined with the land-cover factor is the most important descriptor of the current distribution of the Iberian hare. In addition, the model's output was a reliable index of the local probability of species occurrence, which is a valuable tool to guide species management decisions and conservation planning. Climatic potential obtained for the LGM was combined with molecular data and the results suggest that several glacial refugia may have existed for the species within the major Iberian refugium. Finally, a high probability of occurrence of the Iberian hare in the current species range and a northward expansion were predicted for future. Given its current environmental envelope and evolutionary history, we discuss the macroecology of the Iberian hare and its sensitivity to climate change.

  13. Past, present and future distributions of an Iberian Endemic, Lepus granatensis: ecological and evolutionary clues from species distribution models.

    Science.gov (United States)

    Acevedo, Pelayo; Melo-Ferreira, José; Real, Raimundo; Alves, Paulo Célio

    2012-01-01

    The application of species distribution models (SDMs) in ecology and conservation biology is increasing and assuming an important role, mainly because they can be used to hindcast past and predict current and future species distributions. However, the accuracy of SDMs depends on the quality of the data and on appropriate theoretical frameworks. In this study, comprehensive data on the current distribution of the Iberian hare (Lepus granatensis) were used to i) determine the species' ecogeographical constraints, ii) hindcast a climatic model for the last glacial maximum (LGM), relating it to inferences derived from molecular studies, and iii) calibrate a model to assess the species future distribution trends (up to 2080). Our results showed that the climatic factor (in its pure effect and when it is combined with the land-cover factor) is the most important descriptor of the current distribution of the Iberian hare. In addition, the model's output was a reliable index of the local probability of species occurrence, which is a valuable tool to guide species management decisions and conservation planning. Climatic potential obtained for the LGM was combined with molecular data and the results suggest that several glacial refugia may have existed for the species within the major Iberian refugium. Finally, a high probability of occurrence of the Iberian hare in the current species range and a northward expansion were predicted for future. Given its current environmental envelope and evolutionary history, we discuss the macroecology of the Iberian hare and its sensitivity to climate change.

  14. Multicenter Study of the Clinical Presentation of Staphylococcus lugdunensis Bacteremia in Japan.

    Science.gov (United States)

    Ainoda, Yusuke; Takeshita, Nozomi; Hase, Ryota; Mikawa, Takahiro; Hosokawa, Naoto; Kawamura, Ichiro; Kurai, Hanako; Abe, Masahiro; Kimura, Muneyoshi; Araoka, Hideki; Fujita, Takahiro; Totsuka, Kyoichi; Mezaki, Kazuhisa; Sekiya, Noritaka; Ohmagari, Norio

    2017-07-24

    Staphylococcus lugdunensis (SL) is a bacterium with a highly pathogenicity than most other coagulase-negative Staphylococcus spp. (CoNS). In Japan, data on this pathogen are sparse, and the current prevalence of SL bacteremia is unknown. Therefore, we investigated the prevalence of SL in blood culture specimens in a prospective multicenter study across 5 facilities. A total of 3,284 patients had positive blood cultures, and 2,478 patients had bacteremia. Among the patients with bacteremia, 7 patients (0.28%) had SL bacteremia. A total of 281 patients had CoNS bacteremia, with SL accounting for 2.49% of these cases. Of the 7 patients with SL bacteremia, 1 patient (14.3%) had infective endocarditis, and 1 patient (14.3%) died within 30 days. In this study, SL resulted in the development of bacteremia in select patients. Clinicians in Japan should be aware of the prevalence of SL and the complications of SL bacteremia.

  15. Histopathology findings in patients presenting with menorrhagia: A study of 100 hysterectomy specimen

    Science.gov (United States)

    Sawke, Nilima G.; Sawke, Gopal Krishna; Jain, Hanisha

    2015-01-01

    Background: Menorrhagia, by definition, is heavy cyclical blood loss in excess of 80 ml/month of menstrual period lasting longer than 7 days. There are many possible causes of heavy menstrual bleeding which include hormonal imbalance, fibroids, miscarriage or ectopic pregnancy, nonhormonal intrauterine device, adenomyosis, pelvic inflammatory disease, and rarely uterine, ovarian, or cervical cancer. Treatment depends on the causes of the menorrhagia. Hysterectomy is one of the several surgical procedures as definitive treatment. Objective: To determine the histopathologic spectrum of lesions associated with menorrhagia in different age groups. Study Design: This prospective descriptive study was conducted at the Department of Pathology, People's College of Medical Sciences and Research Centre, Bhopal. During the study period, 100 hysterectomy specimens were taken which were performed for the treatment of menorrhagia. Patients with menorrhagia in the age group of 30-50 years were selected after detailed history and fulfilling the inclusion criteria. Result: In our study, it was observed that maximum number of cases were in the age group of 41-50 years (n = 35) followed by the age group of 31-40 (n = 30). Out of 100 cases, 31% cases (n = 31) showed adenomyosis followed by leiomyomas 25% (n = 25), endometrial hyperplasia 23% (n = 23), and endometrial polyp 4% (n = 4). 11% cases (n = 11) showed dual pathology consisting of both adenomyosis and endometrial hyperplasia and 6% cases (n = 6) of leiomyoma with adenomyosis. Conclusion: Uterine adenomyosis and leiomyoma are the most common benign conditions found in hysterectomy specimens with peak incidence at 31-50 years. Patients having menorrhagia above 40 years should be screened for any endometrial pathology. Histopathology is mandatory for confirming diagnosis and the key to effective therapy and optimal outcome. PMID:26903755

  16. Histopathology findings in patients presenting with menorrhagia: A study of 100 hysterectomy specimen

    Directory of Open Access Journals (Sweden)

    Nilima G Sawke

    2015-01-01

    Full Text Available Background: Menorrhagia, by definition, is heavy cyclical blood loss in excess of 80 ml/month of menstrual period lasting longer than 7 days. There are many possible causes of heavy menstrual bleeding which include hormonal imbalance, fibroids, miscarriage or ectopic pregnancy, nonhormonal intrauterine device, adenomyosis, pelvic inflammatory disease, and rarely uterine, ovarian, or cervical cancer. Treatment depends on the causes of the menorrhagia. Hysterectomy is one of the several surgical procedures as definitive treatment. Objective: To determine the histopathologic spectrum of lesions associated with menorrhagia in different age groups. Study Design: This prospective descriptive study was conducted at the Department of Pathology, People′s College of Medical Sciences and Research Centre, Bhopal. During the study period, 100 hysterectomy specimens were taken which were performed for the treatment of menorrhagia. Patients with menorrhagia in the age group of 30-50 years were selected after detailed history and fulfilling the inclusion criteria. Result: In our study, it was observed that maximum number of cases were in the age group of 41-50 years (n = 35 followed by the age group of 31-40 (n = 30. Out of 100 cases, 31% cases (n = 31 showed adenomyosis followed by leiomyomas 25% (n = 25, endometrial hyperplasia 23% (n = 23, and endometrial polyp 4% (n = 4. 11% cases (n = 11 showed dual pathology consisting of both adenomyosis and endometrial hyperplasia and 6% cases (n = 6 of leiomyoma with adenomyosis. Conclusion: Uterine adenomyosis and leiomyoma are the most common benign conditions found in hysterectomy specimens with peak incidence at 31-50 years. Patients having menorrhagia above 40 years should be screened for any endometrial pathology. Histopathology is mandatory for confirming diagnosis and the key to effective therapy and optimal outcome.

  17. Cases of typhoid fever in Copenhagen region: a retrospective study of presentation and relapse.

    Science.gov (United States)

    Barrett, Freja Cecille; Knudsen, Jenny Dahl; Johansen, Isik Somuncu

    2013-08-11

    Typhoid fever is a systemic illness which in high-income countries mainly affects travellers. The incidence is particularly high on the Indian subcontinent. Travellers who visit friends and relatives (VFR) have been shown to have a different risk profile than others. We wished to identify main characteristics for travellers infected with S. Typhi considering both clinical and laboratory findings in order to provide for faster and better diagnostics in the future. The outcome of treatment, especially concerning relapse, was evaluated as well. Retrospectively collected data from 19 adult cases of typhoid fever over a 5-year period at the Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Denmark. The patients were young adults, presenting with symptoms within a month after travelling. 84% were returned from travelling in the Indian subcontinent. 17 out of 19 patients were VFR-travellers. The main symptoms were fever (100%), gastrointestinal symptoms (84%), headache (58%) and dry cough (26%). Laboratory findings showed elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH) in all cases and elevated alanine transaminase (ALAT) in 47% of cases. In primary cases 4 isolates were fully susceptible to ciprofloxacin, the remaining were intermediate susceptible. Relapse occurred in 37% of the cases and only in cases where the patient was infected by a strain with intermediate susceptibility. Better pre-travel counselling should be given to VFR-travellers. The main symptoms and laboratory findings confirm previous findings. The relapse rate was unexpected high and could be correlated to ciprofloxacin-resistance.

  18. Present status and future prospects of spherical aberration corrected TEM/STEM for study of nanomaterials

    International Nuclear Information System (INIS)

    Tanaka, Nobuo

    2008-01-01

    The present status of Cs-corrected TEM/STEM is described from the viewpoint of the observation of nanomaterials. Characteristic features in TEM and STEM are explained using the experimental data obtained by our group and other research groups. Cs correction up to the 3rd-order aberration of an objective lens has already been established and research interest is focused on correcting the 5th-order spherical aberration and the chromatic aberration in combination with the development of a monochromator below an electron gun for smaller point-to-point resolution in optics. Another fundamental area of interest is the limitation of TEM and STEM resolution from the viewpoint of the scattering of electrons in crystals. The minimum size of the exit-wave function below samples undergoing TEM imaging is determined from the calculation of scattering around related atomic columns in the crystals. STEM does not have this limitation because the resolution is, in principle, determined by the probe size. One of the future prospects of Cs-corrected TEM/STEM is the possibility of extending the space around the sample holder by correcting the chromatic and spherical aberrations. This wider space will contribute to the ease of performing in situ experiments and various combinations of TEM and other analysis methods. High-resolution, in situ dynamic and 3D observations/analysis are the most important keywords in the next decade of high-resolution electron microscopy. (topical review)

  19. Present status and future plans of the study for preparation of Pu reference materials

    International Nuclear Information System (INIS)

    Sumi, Mika; Kageyama, Tomio; Suzuki, Toru

    2007-01-01

    All accountancy analysis at the Plutonium Fuel Development Center of JAEA is performed by isotope dilution mass spectrometry with well-characterized standard materials. Though Pu reference materials has been supplied from foreign country, importing those Pu materials is gradually becoming more difficult and may be almost impossible to import them in future. Thus, in order to establish the capability and expertise for the preparation of Pu reference materials, JAEA has started collaborative work with NBL who has high skills for preparing and supplying nuclear reference materials for long periods. One of the targets of this collaboration is preparation of standard material for IDMS (LSD spike). MOX powder which has been stored in JAEA was dissolved and Purified to obtain Pu solution. A small portion of the Purified solution was transported to NBL for analysis. LSD spike will be prepared from this Pu solution and then validation analysis and performance test including stability test will be performed with NBL and JAEA. This report presents status and future plans for the collaboration work. (author)

  20. Studies on advanced superconductors for fusion device. Pt. 1. Present status of Nb3Sn conductors

    International Nuclear Information System (INIS)

    Tachikawa, Kyoji; Yamamoto, Junya

    1996-03-01

    Nb 3 Sn conductors have been developed with great expectation as an advanced high-field superconductor to be used in fusion devices of next generation. Furthermore, Nb 3 Sn conductors are being developed for NMR magnet and superconducting generator as well as for cryogen-free superconducting magnet. A variety of fabrication procedures, such as bronze process, internal tin process and Nb tube method, have been developed based on the diffusion reaction. Recently, Nb 3 Sn conductors with ultra-thin filaments have been fabricated for AC use. Both high-field and AC performances of Nb 3 Sn conductors have been significantly improved by alloying addition. The Ti-doped Nb 3 Sn conductor has generated 21.5T at 1.8K operation. This report summarizes manufacturing procedures, superconducting performances and applications of Nb 3 Sn conductors fabricated through different processes in different countries. More detailed subjects included in this report are high-field properties, AC properties, conductors for fusion with large current capacities, stress-strain effect and irradiation effect as well as standardization of critical current measurement method regarding to Nb 3 Sn conductors. Comprehensive grasp on the present status of Nb 3 Sn conductors provided by this report will act as a useful data base for the future planning of fusion devices. (author). 172 refs

  1. CT presentations of colorectal cancer with chronic schistosomiasis: A comparative study with pathological findings

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Wei, E-mail: zhangwei976@163.com [Department of Radiology, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065 (China); Wang, Pei-Jun, E-mail: peijunwang_tongji@163.com [Department of Radiology, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065 (China); Shen, Xing, E-mail: shenxing1997@163.com [Department of Radiology, Traditional Chinese Hospital, No. 189, Chaoyangxi Road, Kun Shan 215300, Jiangsu Province (China); Wang, Guo-liang, E-mail: glwang1960@163.com [Department of Radiology, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065 (China); Zhao, Xiao-hu, E-mail: tiger1968@163.com [Department of Radiology, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065 (China); Seema, S.F., E-mail: saaaamaaaa@163.com [Department of Radiology, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065 (China); Zheng, Shao-qiang, E-mail: shaoqiangzh@163.com [Department of Radiology, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065 (China); Li, Ming-hua, E-mail: minghuali@163.com [Department of Radiology, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065 (China)

    2012-08-15

    Objective: To clarify pathological basis of computed tomography (CT) presentations of colorectal cancer (CRC) with schistosomiasis for the purpose of improving the accuracy of CT diagnosis and differential diagnosis of the condition. Materials and methods: 130 patients (87 male and 43 female; age range 49-86 years, mean 71.1) were selected whose diagnoses were pathologically confirmed as CRC with schistosomiasis. All the patients underwent abdominal plain CT and contrast enhanced scanning. The location, morphology, size, calcification features and enhancement modalities (patterns) were evaluated and compared with the pathological findings by two radiologists in a blind way. Results: CT showed that in 130 patients, the tumors occurred in the large intestine, among which 109 (83.9%) were solitary and 21 (16.1%) were multifocal. The intestinal wall was irregularly thickened in 123 patients, with soft tissue masses in 7 patients. Linear, spotty and small patchy calcifications were seen in 104 (80.0%) patients, with unclear margins in 96 patients. The tumors were markedly unevenly enhanced in 92 patients. Pathological examination revealed adenocarcinoma in 114 patients and in 104 patients, calcified Shistosoma japonicum (S. japonicum) ova inside the tumors, 15 patients were mucinous adenocarcinoma, and one patient was that of adenosquamous carcinoma. Conclusion: Irregular thickening of the intestinal wall, soft tissue masses, multiple S. japonicum ova calcifications inside the tumor with obscured margins and multiple intestinal masses in some patients are important CT features of CRC with schistosomiasis.

  2. Study of 222Rn emanation levels present in naturally occurring radioactive materials - NORM

    International Nuclear Information System (INIS)

    Miranda, Marcia Valeria F.E. Sa; Crispim, Verginia Reis; Lima, Clara Teresa S.

    2009-01-01

    The presence of Naturally Occurring Radioactive Material (NORM), contaminating oil and gas installations, is usual in the petroleum industry, and can be severe enough to expose the workers to elevated levels of radiation. The segregation of contaminated residues although necessary, is still a problem without a satisfactory solution. Currently, the most practical and economic option for discarding this material is to stock it in areas of the installation with controlled access. Certain equipment used in the petroleum industry has scale and sludge that could be associated to important levels of radioactivity. Typically, the scales are mixtures of carbonate and sulphate minerals, such as barite (BaSO 4 ), that easily incorporate 226 Ra and 228 Ra in their structures. The objective of this work was to measure the emanations of the radon present in NORM samples, via diffusion chambers containing a nuclear track detector (CR-39). The images of α particle tracks emanated by 222 Rn registered on CR-39 were observed with a Nikon E400 optic microscope and captured by a Nikon Coolpix digital camera and then stored in a database, to later count the tracks using the computational program, Image Pro plus. Since the number of those tracks resulted proportional to the emanation rate of 222 Rn this methodology allowed the comparison of contamination levels in analyzed samples. (author)

  3. Present status and future plan on LMFBR steam generator safety study

    International Nuclear Information System (INIS)

    Tanabe, Hiromi; Kuroha, Mitsuo

    1985-01-01

    The results of the sodium-water reaction test which has been carried out for the safety evaluation of the water leak phenomena in the steam generators for the prototype FBR were summarized. This is related to the behavior of minute leak, the behavior of wear and damage propagation of neighboring tubes due to small and medium leaking jets, and the pressure/flow phenomena occurring at the time of large leak. Moreover, this is related to the development of analysis codes, the development of water leak-detecting system, and the development of the techniques for treating reaction products remaining in the system at the time of accidents. Also the research and development required hereafter for determining the basic specification of the steam generators for a demonstration FBR and future FBRs and reducing the cost were examined. The water leaks in the steam generators for FBRs have been reported in the Fermi reactor of USA, the PFR of Great Britain, the BN-350 of USSR, the Phenix reactor of France and so on. In Japan, the sodium-water reaction has been well understood, and the facilities for the countremeasures to it have been established. The sodium-water reaction phenomena, the present status of sodium-water reaction research and others are reported. (Kako, I.)

  4. Study of the emanation levels of 222Rn present in Naturally Occurring Radioactive Materials - NORM

    International Nuclear Information System (INIS)

    Miranda, Marcia Valeria de Fatima da Encarnacao Sa

    2009-01-01

    The presence of Naturally Occurring Radioactive Material (NORM), contaminating oil and gas facilities, is a common fact in the petroleum industry, and can be severe enough to expose the workers to elevated levels of radiation. Thus, contaminated residues need to be segregated but, this is still a problem without a satisfactory solution. Currently, the most practical and economic option for discarding this material is to stock it in areas of the facility whose access is controlled. Certain equipment used in the petroleum industry has scale and sludge that could be associated to important levels of radioactivity. Typically, the scale is a mixture of carbonate and sulphate minerals, such as barite (BaSO 4 ), that easily incorporates 226 Ra and 228 Ra in its structures. The objective of this work was to measure the emanations of the radon present in these NORM samples, via diffusion chambers containing a nuclear track detector (CR-39). The images of particle alpha tracks emanated by 222 Rn registered on CR-39 were observed with a Nikon E400 optic microscope and captured by a Nikon Coolpix digital camera and then stored in a database, to later count the tracks using the computational program, Image Pro plus. Being that the emanation rate of 222 Rn was proportional to the number of these tracks the methodology permitted the comparison of contamination levels of the analyzed samples. (author)

  5. Descriptive Study of the Presentation of Human Brucellosis in Colombia (2000-2012

    Directory of Open Access Journals (Sweden)

    Patricia Lopez Guarnizo

    2014-07-01

    Full Text Available This research aims to conduct a descriptive study of the occurrence of human brucellosis in Colombia between 2000 and 2012, and, based on previous studies, to determine the prevalence and incidence of the disease, and the limitations for its timely diagnosis and recognition by the Colombian labor system. The research consisted of searching for and analyzing articles on human brucellosis published between 2000 and 2012 in Colombia. It included a phase of information gathering and unstructured interviews with representatives of brucellosis control programs and experienced professionals. We analyzed 17 studies of human brucellosis cases in personnel at risk in slaughterhouses, retailers and vaccinators for animal brucellosis programs: 10 of them reported prevalences between 0.14% and 10.4%, and seven evidenced seropositivity. Information revealed the limitations of the diagnosis, and it demonstrated the little knowledge of the medical community about this disease. In Colombia, there is no clear policy regarding this occupational zoonosis. Brucellosis is mentioned only in Decree 2566 of 2009, in which the new table of occupational diseases is established. The paper concludes that human brucellosis in Colombia is an underdiagnosed, and therefore underreported, disease since there is no mandatory reporting system on the subject.

  6. Active fault and other geological studies for seismic assessment: present state and problems

    International Nuclear Information System (INIS)

    Kakimi, Toshihiro

    1997-01-01

    Evaluation system of earthquakes from an active fault is, in Japan, based on the characteristic earthquake model of a wide sense that postulates essentially the same (nearly the maximum) magnitude and recurrence interval during the recent geological times. Earthquake magnitude M is estimated by empirical relations among M, surface rupture length L, and surface fault displacement D per event of the earthquake faults on land in Japan. Recurrence interval R of faulting/earthquake is calculated from D and the long-term slip rate S of a fault as R=D/S. Grouping or segmentation of complicatedly distributed faults is an important, but difficult problem in order to distinguish a seismogenic fault unit corresponding to an individual characteristic earthquake. If the time t of the latest event is obtained, the 'cautiousness' of a fault can be judged from R-t or t/R. According to this idea, several faults whose t/R exceed 0.5 have been designated as the 'precaution faults' having higher probability of earthquake occurrence than the others. A part of above evaluation has been introduced at first into the seismic-safety examination system of NPPs in 1978. According to the progress of research on active faults, the weight of interest in respect to the seismic hazard assessment shifted gradually from the historic data to the fault data. Most of recent seismic hazard maps have been prepared in consideration with active faults on land in Japan. Since the occurrence of the 1995 Hyogoken-Nanbu earthquake, social attention has been concentrated upon the seismic hazard due to active faults, because this event was generated from a well-known active fault zone that had been warned as a 'precaution fault'. In this paper, a few recent topics on other geological and geotechnical researches aiming at improving the seismic safety of NPPs in Japan were also introduced. (J.P.N.)

  7. Active fault and other geological studies for seismic assessment: present state and problems

    Energy Technology Data Exchange (ETDEWEB)

    Kakimi, Toshihiro [Nuclear Power Engineering Corp., Tokyo (Japan)

    1997-03-01

    Evaluation system of earthquakes from an active fault is, in Japan, based on the characteristic earthquake model of a wide sense that postulates essentially the same (nearly the maximum) magnitude and recurrence interval during the recent geological times. Earthquake magnitude M is estimated by empirical relations among M, surface rupture length L, and surface fault displacement D per event of the earthquake faults on land in Japan. Recurrence interval R of faulting/earthquake is calculated from D and the long-term slip rate S of a fault as R=D/S. Grouping or segmentation of complicatedly distributed faults is an important, but difficult problem in order to distinguish a seismogenic fault unit corresponding to an individual characteristic earthquake. If the time t of the latest event is obtained, the `cautiousness` of a fault can be judged from R-t or t/R. According to this idea, several faults whose t/R exceed 0.5 have been designated as the `precaution faults` having higher probability of earthquake occurrence than the others. A part of above evaluation has been introduced at first into the seismic-safety examination system of NPPs in 1978. According to the progress of research on active faults, the weight of interest in respect to the seismic hazard assessment shifted gradually from the historic data to the fault data. Most of recent seismic hazard maps have been prepared in consideration with active faults on land in Japan. Since the occurrence of the 1995 Hyogoken-Nanbu earthquake, social attention has been concentrated upon the seismic hazard due to active faults, because this event was generated from a well-known active fault zone that had been warned as a `precaution fault`. In this paper, a few recent topics on other geological and geotechnical researches aiming at improving the seismic safety of NPPs in Japan were also introduced. (J.P.N.)

  8. Report of International Workshop on tracing isotopic composition of past and present precipitation - opportunities for climate and water studies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The Workshop on Tracing Isotopic Composition of Past and Present Precipitation - Opportunities for Climate and Water Studies, was jointly organized by the World Meteorological Organization (WMO), the International Atomic Energy Agency (IAEA), Past Global Changes (PAGES) - a core project of the International Geosphere - Biosphere Programme (IGBP), and the International Association of Hydrological Sciences (IAHS). The Global Network ``Isotopes in Precipitation`` (GNIP) was initiated by IAEA in 1958 and became operational in 1961. The main objective was to collect systematic data on isotopic content of precipitation on a global scale and to establish temporal and spatial variations of environmental isotopes in precipitation. The network is now expected to serve additional purposes, namely as a benchmark for the interpretation of paleo-records, as a validation tool for Global Circulation Models, and for establishing large-scale regional (and continental-scale) waster balances. Furthermore, the structure of GNIP should be strengthened. This includes the build-up of: stations located close to major natural climatic archives (e.g. Greenland, mountain areas); stations which represent climatically sensitive areas (indicated by GCM`s and biome models). Isotope monitoring of river outflow from major continental basins should be initiated. This could be realized in co-operation with the UNEP/WHO Global Environmental Monitoring System-Water (GEMS-Water). The deuterium excess parameter ({delta}) is of particular importance in climate modelling and in the understanding of hydro-meteorological pathways. The use of the deuterium excess imposes strict requirements on the accuracy of deuterium and oxygen-18 analysis. A GNIP-based worldwide documentation of quality control regarding sampling, shipping and measurements is needed. The IAEA/WMO database and other isotope data sets should be included in the World Data Center A for palaeo-climatology. Refs, figs, tabs.

  9. Report of International Workshop on tracing isotopic composition of past and present precipitation - opportunities for climate and water studies

    International Nuclear Information System (INIS)

    1995-01-01

    The Workshop on Tracing Isotopic Composition of Past and Present Precipitation - Opportunities for Climate and Water Studies, was jointly organized by the World Meteorological Organization (WMO), the International Atomic Energy Agency (IAEA), Past Global Changes (PAGES) - a core project of the International Geosphere - Biosphere Programme (IGBP), and the International Association of Hydrological Sciences (IAHS). The Global Network ''Isotopes in Precipitation'' (GNIP) was initiated by IAEA in 1958 and became operational in 1961. The main objective was to collect systematic data on isotopic content of precipitation on a global scale and to establish temporal and spatial variations of environmental isotopes in precipitation. The network is now expected to serve additional purposes, namely as a benchmark for the interpretation of paleo-records, as a validation tool for Global Circulation Models, and for establishing large-scale regional (and continental-scale) waster balances. Furthermore, the structure of GNIP should be strengthened. This includes the build-up of: stations located close to major natural climatic archives (e.g. Greenland, mountain areas); stations which represent climatically sensitive areas (indicated by GCM's and biome models). Isotope monitoring of river outflow from major continental basins should be initiated. This could be realized in co-operation with the UNEP/WHO Global Environmental Monitoring System-Water (GEMS-Water). The deuterium excess parameter (δ) is of particular importance in climate modelling and in the understanding of hydro-meteorological pathways. The use of the deuterium excess imposes strict requirements on the accuracy of deuterium and oxygen-18 analysis. A GNIP-based worldwide documentation of quality control regarding sampling, shipping and measurements is needed. The IAEA/WMO database and other isotope data sets should be included in the World Data Center A for palaeo-climatology. Refs, figs, tabs

  10. The Impact of Pecha Kucha Presentations in the Assessment of a Translation Studies Unit at the University of Western Australia

    Science.gov (United States)

    Colombi, Anna Gadd

    2017-01-01

    Results of a case study on the implementation of Pecha Kucha presentations undertaken at The University of Western Australia in 2015 are presented and discussed here. Pecha Kucha, a fast-paced presentation format consisting of 20 slides set to proceed automatically every 20 seconds, was used in the assessment of the unit "Translation…

  11. Encountering the past in the present: An exploratory study of educational heritage tourism

    Science.gov (United States)

    Gross, Magdalena H.; Kelman, Ari Y.

    2017-02-01

    This article presents an educational programme designed to explore the multicultural history of Poland. Targeting Jewish and non-Jewish students of Polish heritage, the Polonia Programme (PP) was conceptualised with the aim of applying the tools of experiential education to initiate a new approach to examining one of the world's most challenging and fraught historical narratives. The programme, piloted in the summer of 2014, takes two groups of young people from the United States to Poland each year. It features a combination of formal lectures and interactive tours, complemented by structured and semi-structured discussions. The destination of this particular tour, with these particular participants, both challenges and reinforces accepted notions of "heritage tourism" within an experiential educational framework. This framework enables a sense of group connectivity which allows students to be, perhaps, more open to alternative narratives about the past. The authors of this article, who were involved in evaluating the pilot launch of the Polonia Programme, found that the programme's experiential approach succeeded in encouraging participants in the pilot cohort to challenge ideas about their definitions of and preconceptions about "who and what counts as Polish". For many, the experience shifted their understanding of Poland towards one which took its multi-ethnic and multicultural history into account. Several discovered new perspectives on their own identity and heritage, while others reached a new understanding of the shared histories of Poles and Jews. The experiential nature of this programme also allowed students to encounter difficult histories: experience, then, became a vehicle for more challenging conversations and deeper learning.

  12. Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects

    Directory of Open Access Journals (Sweden)

    Dwarakanath B

    2009-09-01

    Full Text Available Higher rates of glucose usage generally correlate with poor prognosis in several types of malignant tumours. Experimental studies (both in vitro and in vivo have shown that 2-deoxy-D-glucose (2-DG, a glucose analog and glycolytic inhibitor, enhances radiation-induced damage selectively in tumor cells while protecting normal cells, thereby suggesting that 2-DG can be used as a differential radiomodifier to improve the efficacy of radiotherapy. Clinical trials undertaken to study the feasibility, safety, and validity of this suggested approach will be described. Based on 2-DG-induced radiosensitization observed in primary organ cultures of cerebral glioma tissues, clinical trials were designed taking into consideration the radiobiology of gliomas and pharmacokinetics of 2-DG. Phase I/II clinical trials have unequivocally demonstrated that a combination of 2-DG (200-300 mg 2-DG per kg body weight orally administered after overnight fasting, 20min before irradiation with large weekly fractions (5 Gy/fraction of low-LET radiotherapy is well tolerated without any acute toxicity or late radiation damage to the normal brain tissue. Nonserious transient side effects similar to hypoglycemia induced disturbances like restlessness, nausea, and vomiting were observed at the 2-DG doses used. Data from these trials involving more than 100 patients have clearly indicated a moderate increase in the survival, with a significant improvement in the quality of life with clinicopathological evidence of protection of normal brain tissue. A phase III multicentric trial to evaluate the efficacy of the combined treatment is in progress. Directions for future studies are discussed.

  13. The past, present, and future of soils and human health studies

    Science.gov (United States)

    Brevik, E. C.; Sauer, T. J.

    2015-01-01

    The idea that human health is tied to the soil is not a new one. As far back as circa 1400 BC the Bible depicts Moses as understanding that fertile soil was essential to the well-being of his people. In 400 BC the Greek philosopher Hippocrates provided a list of things that should be considered in a proper medical evaluation, including the properties of the local ground. By the late 1700s and early 1800s, American farmers had recognized that soil properties had some connection to human health. In the modern world, we recognize that soils have a distinct influence on human health. We recognize that soils influence (1) food availability and quality (food security), (2) human contact with various chemicals, and (3) human contact with various pathogens. Soils and human health studies include investigations into nutrient supply through the food chain and routes of exposure to chemicals and pathogens. However, making strong, scientific connections between soils and human health can be difficult. There are multiple variables to consider in the soil environment, meaning traditional scientific studies that seek to isolate and manipulate a single variable often do not provide meaningful data. The complete study of soils and human health also involves many different specialties such as soil scientists, toxicologists, medical professionals, anthropologists, etc. These groups do not traditionally work together on research projects, and do not always effectively communicate with one another. Climate change and how it will affect the soil environment/ecosystem going into the future is another variable affecting the relationship between soils and health. Future successes in soils and human health research will require effectively addressing difficult issues such as these.

  14. Study on the surfactants present in atmospheric aerosols collected in the Okinawa Japan

    Science.gov (United States)

    Kamegawa, A.; Kasaba, T.; Shimabukuro, W.; Arakaki, T.

    2017-12-01

    The main constituent of atmospheric aerosols is organic substances, which occupy 20 to 70% of the mass. Organic matters in the aerosols contain organic acids, protein and humic acid, which behave similar to surfactants. Since surfactants contain both hydrophobic and hydrophilic functional groups in the molecule, they can play important roles in cloud formation and can affect climate change, but detailed mechanisms and magnitude are not well understood. In addition, surfactants can cause asthma, allergy, dry eye and so on. In this study, our aim is to characterize surfactants in the aerosols collected in different seasons in Okinawa, Japan. Atmospheric aerosols were collected at Cape Hedo Atmosphere and Aerosol Monitoring Station (CHAAMS) during Sep. 2013 and July 2014. Surfactants in the environment are comprised of artificially synthesized compounds and naturally derived organics so we only differentiate them into anionic and cationic surfactants. Colorimetric methods were used to determine the concentrations of anionic surfactants as methylene blue active substance (MBAS). Cationic surfactants were also measured by colorimetric method as disulfine blue active substance (DBAS) and showed always below detection limit. Thus, we only discuss anionic surfactants measured as MBAS. Water soluble organic carbon (WSOC) and metal concentrations were also measured for the same aerosol samples. Concentrations of MBAS in the studied samples were 2-3 times higher in spring, fall and winter than those collected in summer. MBAS concentration in the aerosols showed strong correlation with sulfate ion and WSOC, and slightly weaker correlation with nss-sulfate ion. Among the metals, only sodium ion showed a relatively strong correlation with MBAS concentrations. It is suggested that the anionic surfactants in the studied aerosols are mainly derived from marine sources.

  15. Electroweak precision observables and Higgs-boson signal strengths in the Standard Model and beyond: present and future

    Energy Technology Data Exchange (ETDEWEB)

    Blas, J. de [INFN, Sezione di Roma,Piazzale A. Moro 2, I-00185 Rome (Italy); Ciuchini, M. [INFN, Sezione di Roma Tre,Via della Vasca Navale 84, I-00146 Roma (Italy); Franco, E. [INFN, Sezione di Roma,Piazzale A. Moro 2, I-00185 Rome (Italy); Mishima, S. [Theory Center, Institute of Particle and Nuclear Studies (IPNS),High Energy Accelerator Research Organization (KEK),1-1 Oho, Tsukuba, 305-0801 (Japan); Pierini, M. [CERN,Geneva (Switzerland); Reina, L. [Physics Department, Florida State University,77 Chieftan Way, Tallahassee, FL 32306-4350 (United States); Kavli Institute for Theoretical Physics, University of California,Kohn Hall, Santa Barbara, CA 93106-4030 (United States); Silvestrini, L. [INFN, Sezione di Roma,Piazzale A. Moro 2, I-00185 Rome (Italy)

    2016-12-27

    We present results from a state-of-the-art fit of electroweak precision observables and Higgs-boson signal-strength measurements performed using 7 and 8 TeV data from the Large Hadron Collider. Based on the HEPfit package, our study updates the traditional fit of electroweak precision observables and extends it to include Higgs-boson measurements. As a result we obtain constraints on new physics corrections to both electroweak observables and Higgs-boson couplings. We present the projected accuracy of the fit taking into account the expected sensitivities at future colliders.

  16. Present situation concerning studies on associative n-fixation in sugarcane, 'Saccharum officinarum' L

    International Nuclear Information System (INIS)

    Ruschel, A.P.; Vose, P.B.

    1977-01-01

    High nitrogenase activity in sugarcane has been confirmed, using 15 N procedure, which indicated rapid translocation of the fixed nitrogen to the plant tissue. It is observed that there are differences in variety concerning nitrogenase activity in the rhizosphere of sugarcane. Basic calculations and an evaluation of possible biological N-fixation with 15 N suggest that possibly as much as 25-30% of the plant nitrogen may be derived from biological fixation. Both eight and electron microscope studies suggest that there are bacteria inside healthy roots and if such a root is surface sterilized and placed ou nitrogen-free media then bacteria stream from the cut surface [pt

  17. Model analyses of atmospheric mercury: present air quality and effects of transpacific transport on the United States

    Science.gov (United States)

    Lei, H.; Liang, X.-Z.; Wuebbles, D. J.; Tao, Z.

    2013-11-01

    Atmospheric mercury is a toxic air and water pollutant that is of significant concern because of its effects on human health and ecosystems. A mechanistic representation of the atmospheric mercury cycle is developed for the state-of-the-art global climate-chemistry model, CAM-Chem (Community Atmospheric Model with Chemistry). The model simulates the emission, transport, transformation and deposition of atmospheric mercury (Hg) in three forms: elemental mercury (Hg(0)), reactive mercury (Hg(II)), and particulate mercury (PHg). Emissions of mercury include those from human, land, ocean, biomass burning and volcano related sources. Land emissions are calculated based on surface solar radiation flux and skin temperature. A simplified air-sea mercury exchange scheme is used to calculate emissions from the oceans. The chemistry mechanism includes the oxidation of Hg(0) in gaseous phase by ozone with temperature dependence, OH, H2O2 and chlorine. Aqueous chemistry includes both oxidation and reduction of Hg(0). Transport and deposition of mercury species are calculated through adapting the original formulations in CAM-Chem. The CAM-Chem model with mercury is driven by present meteorology to simulate the present mercury air quality during the 1999-2001 period. The resulting surface concentrations of total gaseous mercury (TGM) are then compared with the observations from worldwide sites. Simulated wet depositions of mercury over the continental United States are compared to the observations from 26 Mercury Deposition Network stations to test the wet deposition simulations. The evaluations of gaseous concentrations and wet deposition confirm a strong capability for the CAM-Chem mercury mechanism to simulate the atmospheric mercury cycle. The general reproduction of global TGM concentrations and the overestimation on South Africa indicate that model simulations of TGM are seriously affected by emissions. The comparison to wet deposition indicates that wet deposition patterns

  18. The Appreciation and Study of Qur’an Manuscripts from Southeast Asia: Past, Present, and Future

    Directory of Open Access Journals (Sweden)

    Annabel Teh Gallop

    2016-01-01

    Full Text Available The focus of this paper is not on theological aspects of the Qur’an, or on the study of the Qur’anic sciences in Southeast Asia over the past centuries, but rather to attempt to trace the path of the appreciation of old copies of the Qur’an in Southeast Asia as part of the historical record of the Islamic heritage of the region.  In this light, Qur’an manuscripts are viewed as objects of material culture which can cast light on the societies which produced them, and as works of art which testify to the heights of artistic creativity in the region, for illuminated Qur’an manuscripts represent the pinnacle of achievements in the arts of the book in Southeast Asia. This historical record can be measured through a survey of how, where, when and by whom Qur’an manuscripts in Southeast Asia were collected, documented, studied and published, both in Southeast Asia itself and in the west.

  19. A short introduction to cytogenetic studies in mammals with reference to the present volume.

    Science.gov (United States)

    Graphodatsky, A; Ferguson-Smith, M A; Stanyon, R

    2012-01-01

    Genome diversity has long been studied from the comparative cytogenetic perspective. Early workers documented differences between species in diploid chromosome number and fundamental number. Banding methods allowed more detailed descriptions of between-species rearrangements and classes of differentially staining chromosome material. The infusion of molecular methods into cytogenetics provided a third revolution, which is still not exhausted. Chromosome painting has provided a global view of the translocation history of mammalian genome evolution, well summarized in the contributions to this special volume. More recently, FISH of cloned DNA has provided details on defining breakpoint and intrachromosomal marker order, which have helped to document inversions and centromere repositioning. The most recent trend in comparative molecular cytogenetics is to integrate sequencing information in order to formulate and test reconstructions of ancestral genomes and phylogenomic hypotheses derived from comparative cytogenetics. The integration of comparative cytogenetics and sequencing promises to provide an understanding of what drives chromosome rearrangements and genome evolution in general. We believe that the contributions in this volume, in no small way, point the way to the next phase in cytogenetic studies. Copyright © 2012 S. Karger AG, Basel.

  20. APECS: A Model Organization for Bridging Past to Present and Developing a New Generation of Polar Scientists (Invited)

    Science.gov (United States)

    Timm, K.; Baeseman, J. L.; Membership, Association Of Polar Early Career Scientists

    2010-12-01

    activities—which are often not part of a traditional science graduate program of study. APECS is proof that a community driven effort can become a robust professional organization in just a few short years. Working with senior scientists and other mentors, such as non-science faculty members, educators, members of the media, administrative professionals, and policy makers, to build capacity of the membership and the organization is a major lesson from the establishment of APECS. Additional lessons include, nurturing your volunteers and new ideas. By building connections between senior scientists, and established polar science organizations to new scientists and professionals and fresh ideas APECS is creating a continuum by which polar science can effectively transition from observation, to synthesis, and towards response. In a period where the polar regions are experiencing rapid environmental change, having the tools and skills to work effectively cross-discipline and within, as well as outside the scientific community, will be essential to address the changes through science-based policy and a well-informed public. APECS can serve as a model for other early career initiatives in many disciplines and countries.

  1. A case study presentation: The MAG3 captopril renal scan, which side are you on ?

    International Nuclear Information System (INIS)

    Richards, A.

    1998-01-01

    Full text: A 68-year-old woman with widespread vascular disease presented to the Nuclear Medicine Department with severe hypertension, (a blood pressure of 200/160 supine), a known small right kidney, and a large abdominal aortic aneurysm. A baseline renal scan was performed with IV administration of 300 MBq of 99m Tc-labelled MAG3. A normal left kidney was demonstrated, with a Grade 0 renogram pattern. The right kidney was non visualised and non functioning. The patient was then administered orally with 25 mg of A.C.E. inhibitor captopril and her blood pressure fell by greater than 100 mm Hg. A second MAG3 Renal Scan was performed. The finding conflicted with results of a Renal Artery Angiogram and Renal Artery Doppler Ultrasound, both demonstrating a normal left renal artery. A repeat MAG3 Renal scan with captopril challenge was performed. Differential diagnosis included: 1.Left sided microvascular disease; 2. A functioning though very ischaemic right kidney that was producing renin, suggested by contrast opacification of the right renal cortex on CT; or 3. A false negative renal artery angiogram, with non-visualisation of an arterial stenosis caused by thrombus or compression of the left renal artery by the abdominal aortic aneurysm. Subsequent Renal Vein Renin Sampling measured left renal vein renin activity at 4.50,μg/L/h, (compared with 4.80μg/L/h in the IVC). Right renal vein renin activity was 13.20μg/L/h. This lateralization of renin secretion to the right side with suppression of left sided secretion suggested that the renovascular hypertension was caused by the right kidney. This was a very unusual result, as the MAG3 captopril renal scan had incorrectly and strongly suggested a left sided origin to the renovascular hypertension. In addition, the right kidney not seen to accumulate MAG3 was in fact functioning sufficiently to produce renin. It is hypothesized that the left kidney had adjusted to allow normal function only at very high circulating

  2. The BAMSE project: presentation of a prospective longitudinal birth cohort study.

    Science.gov (United States)

    Wickman, Magnus; Kull, Inger; Pershagen, Göran; Nordvall, S Lennart

    2002-01-01

    The aims of this prospective and longitudinal project are to establish crucial risk factors for asthma and other allergic diseases in childhood, and to study factors of importance for prognosis at already established allergic disease. Socio-economic factors, such as inequality in health, are also to be addressed. The project started in February 1994. To reach sufficient power, 4,000 children had to be included. In November 1996, this number was reached (4,093). Inclusion in the study was made at 3-4 months of age. At that time, and before induction of allergic disease/ asthma of the child, a questionnaire focused on exposure, genetics and socio-economic factors was answered. Settled dust was sampled for later analysis of furred animal and mite allergens. When the children were aged both 1 and 2 years, their parents were asked to fill in new questionnaires focusing on respiratory and allergic (skin, gastrointestinal) symptoms, but also key variables of exposure. Cases with asthma are identified and, for every case, two matched controls drawn. During the following winter, the homes of cases and controls were investigated and the temperature, indoor humidity, air change rate and NO2 measured. Two hundred cases (5%) were expected to be identified during the first 2 years of the children's lives. Some 479 homes have now been investigated and 97.7% of the original 4,093 children still remain in the cohort. The 2-year symptom follow-up ended in November 1998. The 4-year follow-up started on 1 September 1998 and was planned to be finished in June 2000. Questionnaires (allergic and respiratory symptoms, key variables of exposure at home and day care) are sent out to all 4,093 families. All children are invited for examination, lung function tests (PEF, flow-volume, MVV and oxygen clearance) and physical performance. Blood is taken from all children (20 ml). Allergy screening is performed and specific IgE examined. Blood cells will be frozen to allow for later DNA extraction

  3. [Do the practices developed in Family Health Program contribute to transform the present model of health care].

    Science.gov (United States)

    Shimizu, Helena Eri; Rosales, Carlos

    2009-01-01

    This study aimed to identify and analyze the main primary health care practices developed in the Family Health Care Program. Qualitative case study was carried out in the region of São Sebastião, DF. Data were collected through semi-structured interviews with team workers and observation of the work process. The author concluded that diverse basic practices are developed in primary health care, but others practices focused in health care promotion are necessary in order to transform the health care model.

  4. [The use of personal sources for the study of emigration from Galicia: present state and perspectives].

    Science.gov (United States)

    Vazquez Gonzalez, A

    1996-08-01

    "Spanish sources for the study of emigration are sparse and fragmentary.... Mortgage documents for the payment of ocean transportation enable us to appreciate the spreading action of shipping agents; official listings of draft dodgers reveal that in general the River Plate was a favorite destination, rather than Cuba or Brazil. People from Galicia emigrated from rural origins to urban destinations in America; the analysis of place of birth of emigrants residing in A Coruna at the time of emigration show that there was also, in some cases, a first stage of rural-urban migration within Galicia. The general picture of emigration from Galicia is built [up] through the combination of the existing sources in Spain." (EXCERPT)

  5. Present status of study on super-critical water cooled reactor

    International Nuclear Information System (INIS)

    Ookawa, Masahiro; Shiga, Shigenori; Moriya, Kumiaki; Oka, Yoshiaki; Yoshida, Suguru; Takahashi, Heishichiro

    2003-01-01

    Reactor structure design, the core design and coolant flow in sub-channel of fuel assembly are evaluated in the subtitle of plant concepts of the 2002 fiscal year. High temperature parts and high pressure parts are separated on the reactor structure design. Reactor pressure vessel (RPV) is designed under the condition of low temperature and high pressure, while, apparatuses and instruments in the reactor core are designed under the condition of high temperature and low pressure. Design of control rods for cold shut down of the reactor are estimated by using monte carlo computation code (MCNP). It reveals that the number of 16 control rods (0.7 cm in dia) per a fuel assembly is needed for getting control rod worth of conventional light water reactor. Radial power peaking factor reduces to 1.27 by using a load pattern of fuel assembly, number and load position of fuel elements with burnable poison and control rod pattern. Distributions of coolant flow rate in the fuel assembly are studied by sub-channel analysis code, SILFEED, for BWR. The fuel assembly with 1.0 mm gaps between fuel rod and water keeps an uniform flow distribution in which no sub-channel below 90% of flow rate appears in the fuel assembly. Heat transfer experiments for a single test fuel are carried out in the subtitle of heat transfer. The heat transfer data obtained by the experiments are fitted well to Watts' formula. Slow strain rate tests (SSRT) for SUS 304 and SUS 316L steels in the subtitle of materials are carried out for studying stress corrosion cracking (SCC) of the materials under the super-critical pressure water environment. Intergranular stress corrosion cracking (IGSCC) takes place in SUS 304, but doesn't take place in SUS 316L. (M. Suetake)

  6. Wood product industry - present state and studies of the development alternatives; Puuteollisuuden nykytilan ja haasteiden arviointia

    Energy Technology Data Exchange (ETDEWEB)

    Holmijoki, O.; Paajanen, T.; Kairi, M.

    2007-07-01

    In this research project the development of the wood products industry and its operating environment in Finland was studied using statistical data mainly from years 1995 - 2003. In this context, the wood products industry includes the sawmilling industry, the plywood and other wood panel industry, prefabricated wooden housing and the building joinery industry, wood packing manufacture and the manufacture of other wooden products. The development of the wood products industry and its operating environment has been estimated by combining statistical data about the business economy, production economy and the national economy from the Central Statistical Office of Finland together with data from the Finnish Forest Research Institute. Based on statistical data, the wood product markets, profitability and cost structure of branches, input market, use of labour force and investments have been studied. The economic importance of the wood products industry has been estimated at a national and a local level. Challenges facing wood products industry branches have been analysed using example calculations based on input-output theory. In the evaluation method, the business environment of the wood products industry branches and related branches, have been described with a use table at basic prices commonly using in the national economy. This method has enabled the direct and indirect effects of simultaneous quantity and price changes occurring in the wood product markets and markets related to the wood product industry, to be analysed. In the example calculations, variation of sawn timber production and log import, as well as the increments of sawn timber upgrading, wood product usage in building, wood panel production and purchase energy price, were reviewed

  7. Technical data report : marine acoustics modelling study

    Energy Technology Data Exchange (ETDEWEB)

    Chorney, N.; Warner, G.; Austin, M. [Jasco Applied Sciences, Victoria, BC (Canada)

    2010-07-01

    This study was conducted to predict the ensonification produced by vessel traffic transiting to and from the Enbridge Northern Gateway Project's marine terminal located near Kitimat, British Columbia (BC). An underwater acoustic propagation model was used to model frequency bands from 20 Hz to 5 kHz at a standard depth of 20 metres. The model included bathymetric grids of the modelling area; underwater sound speed as a function of depth; and geo-acoustic profiles based on the stratified composition of the seafloor. The obtained 1/3 octave band levels were then used to determine broadband received sound levels for 4 scenarios along various transit routes: the Langara and Triple Island in Dixon Entrance; the Browning Entrance in Hecate Strait, and Cape St. James in the Queen Charlotte Basin. The scenarios consisted of a tanker transiting at 16 knots, and an accompanying tug boat. Underwater sound level maps for each scenario were presented. 14 refs., 5 tabs., 16 figs.

  8. Long-term prognosis of patients presenting first-ever vestibular symptoms in a community-based study.

    Science.gov (United States)

    Felgueiras, Rui; Magalhães, Rui; Correia, Manuel; Silva, Maria Carolina

    2014-09-01

    Vestibular symptoms (VSs) are frequent complaints in patients attending ambulatory care and the emergency room. They may represent a peripheral vestibular disorder or a stroke/transient ischemic attack (TIA), yet many patients have VSs that cannot be clearly classified at presentation. This study aims to characterize and determine the long-term prognosis of these patients. In a prospective community-based study involving 104,700 individuals registered at 4 health centers of Northern Portugal, patients with a first-ever-in-lifetime focal neurologic symptom (FNS) were ascertained using comprehensive methods, including referrals from physicians working in the study area and data retrieved from emergency/discharge records. Physicians were encouraged to report/notify any patient who might have experienced an FNS, including those with vertigo or vertigo-like symptoms, imbalance, presyncope, or nonspecific dizziness. After neurologic assessment patients were classified as having a peripheral vestibular symptom (pVS), a stroke/TIA, or an unclassified vestibular symptom (uVS). They were followed up 7 years after the index event at the outpatient clinic; predictors of survival free from stroke or vascular events were determined using Cox proportional hazards models. Of the 1163 patients with an FNS, 360 (31.0%) were included, 16.7% had a stroke/TIA, 57.8% had pVS, and 25.6% had uVS. Most patients presented only isolated VSs (62.8%); 63% were women and mean age was 60.1 years (standard deviation = 16); hypertension (47.8%), hypercholesterolemia (41.9%), and diabetes (19.2%) were the most prevalent vascular risk factors (VRFs). Cranial computed tomography (CT) scan was performed in 63.3%. Adjusting for age, sex, VRFs, and diagnosis (TIA, pVS and uVS), the long-term risk of stroke was higher when CT showed silent infarctions (hazard rate [HR] = 3.96; 95% confidence interval [CI], 1.63-9.60) and the risk of vascular events (stroke, myocardial infarction, or vascular death) was

  9. Conservatism of present plugging criteria on steam generator tubes and coalescence model of collinear through-wall axial cracks

    International Nuclear Information System (INIS)

    Lee, Jin Ho; Park, Youn Won; Song, Myung Ho; Kim, Young Jin; Moon, Seong In

    1999-01-01

    The steam generator tubing covers a major portion of the primary pressure-retaining boundary, so that very conservative approaches were taken in the light of steam generator tube integrity. According to the present criteria, tubes wall-thinned in excess of 40% should be plugged whatever the cause was. However, it is reported that there is no safety problem even with thickness reductions greater than 40%. Recently, the plant specific plugging criteria are introduced in many countries by demonstrating that the cracked tube has a sufficient safety margin. One of the drawbacks of such criteria, even though not yet codified, is that it is developed based on tubes with single cracks regardless of the fact that the appearance of multiple cracks is general. Their failure analyses have been, therefore, carried out using an idealized single crack to reduce complexity till now. The objective of this paper is to review the conservatism of the present plugging criteria of steam generator tubes and to propose a new coalescence criterion for twin through-wall cracks existing in steam generator tubes. Using the existing failure models and experimental results, we review the conservatism of the present plugging criteria. In order to verify the usefulness of the proposed new coalescence criterion, we perform finite element analysis

  10. BIOMOVS: an international model validation study

    International Nuclear Information System (INIS)

    Haegg, C.; Johansson, G.

    1988-01-01

    BIOMOVS (BIOspheric MOdel Validation Study) is an international study where models used for describing the distribution of radioactive and nonradioactive trace substances in terrestrial and aquatic environments are compared and tested. The main objectives of the study are to compare and test the accuracy of predictions between such models, explain differences in these predictions, recommend priorities for future research concerning the improvement of the accuracy of model predictions and act as a forum for the exchange of ideas, experience and information. (author)

  11. BIOMOVS: An international model validation study

    International Nuclear Information System (INIS)

    Haegg, C.; Johansson, G.

    1987-01-01

    BIOMOVS (BIOspheric MOdel Validation Study) is an international study where models used for describing the distribution of radioactive and nonradioactive trace substances in terrestrial and aquatic environments are compared and tested. The main objectives of the study are to compare and test the accuracy of predictions between such models, explain differences in these predictions, recommend priorities for future research concerning the improvement of the accuracy of model predictions and act as a forum for the exchange of ideas, experience and information. (orig.)

  12. Present status of tandem accelerator analysis facility in National Institute for Environmental Studies

    Energy Technology Data Exchange (ETDEWEB)

    Kume, Hiroshi; Shibata, Yasuyuki; Tanaka, Atsushi; Yoneda, Minoru; Kumamoto, Yuichiro; Uehiro, Takashi; Morita, Masatoshi [National Inst. for Environmental Studies, Tsukuba, Ibaraki (Japan)

    1996-12-01

    In National Institute for Environmental Studies, two types of tandem accelerator analysis facilities were able to be installed in September, 1995. One is the accelerator mass analysis exclusive equipment with a 5 MV tandem accelerator, and the other is the high energy ion beam analyzer, in which the surface analysis system is connected to a 1 MV tandem accelerator, mainly used for PIXE measurement. The accelerator mass analyzer can be roughly divided into four parts, that is, ion source and negative ion injection system, accelerator, high energy analysis system, minute amount isotope beam line and control system. These parts are briefly explained. The test measurement of carbon isotope ratio was carried out, but the results dispersed and unsatisfactory. As for the ion beam analyzer, the surface analysis system (RBS400) of Charles Evans and Associates is combined with a 1 MV PELETRON tandem accelerator (3SDH) of NEC, and these are described. This analyzer also is not in the state that the steady operation can be carried out. Slight leak occurred in the ion source. The countermeasures to both cases are in progress. (K.I.)

  13. Patient characteristics upon initial presentation to chiropractic teaching clinics: A descriptive study conducted at one university

    Science.gov (United States)

    Kaeser, Martha A.; Hawk, Cheryl; Anderson, Michelle

    2014-01-01

    Objective The purpose of this study was to compare demographics and chief complaints of the new patient population at our institution's fee-for-service clinics to the patient population of practicing chiropractors in the United States. We also compared the prevalence of obesity and hypertension to reference standards for the adult population. Methods Patient data were obtained from the electronic health records. All records identified as new patients during October 2013 were included. Variables of interest were clinic site, patient demographics, blood pressure, body mass index (BMI), chief complaint, and ICD-9 codes. Descriptive statistics were computed and compared to reference standards from previous reports. Results During October 2013, there were 224 new patients that entered the clinics. The average patient was a 31- to 50-year-old white male. Our clinic patients differed from those seen by US chiropractors in the distribution of all demographic variables. For adult patients, 31.4% were overweight, 29% were obese, and 8% stage 1 or 2 hypertension. Conclusion New patients in the fee-for-service teaching clinics appear to be dissimilar to those of US practicing chiropractors in several important demographics, characteristics, and types of complaints. The new patients had lower levels of overweight, obesity, and hypertension compared to US reference standards. PMID:25162982

  14. A comparative study for the echo cardiographic, radiologic and electrocardiographic presentation of the sport heart hypertrophy

    International Nuclear Information System (INIS)

    Reinke, A.

    1982-01-01

    In this work the three most important non-invasive methods - X-ray pictures, electrocardiography and echo cardiography - were compared as to their ability to evaluate the physiological heart enlargement as a result of physical training. Important also was the study of the value of ultrasonic cardiographs. The subjects used were 162 athletes, 36 patients with cardiovascular diseases, and 22 non-athletic control persons. Radiologically the changes in the total size of the heart were determined. For the question of the adapting reaction of the heart because of athletic training the weight-related heart volume is more meaningful than the absolute value. Electrocardiographically it is not possible to come up with any statistically significant statements about the physiological heart enlargement using the Sokoloff-Lyon indexes. Echo cardiographically the regulative heart enlargements can be differentiated into myocardial hypertrophy or ventricular dilation. As a result of this a line can be drawn between physiological and pathological changes. Female athletes show qualitatively, but not quantitatively, the same adapting reaction. The synopsis of the three procedures shows that echo cardiography and radiology show better results than does electrocardiography. Together the methods complement each other in their diagnostic power. (orig./TRV) [de

  15. Present status and perspectives of heavy ion studies on cells and organisms

    International Nuclear Information System (INIS)

    Yang, T.C.; Craise, L.M.; Mei Mantong.

    1992-01-01

    Biomedical research of heavy ion radiation has been an unique and highly active field in past two decades. Through these intensive research efforts, significant amount of quantitative and qualitative data, which provide insights into biological effects, have been obtained. RBE and LET relationship has been well established for cell inactivation, somatic mutation, and cancer induction. In addition, the effects of oxygen and cell cycle on radiosensitivity of mammalian cells, exposed to heavy ions, have been examined. In spite of such large quantitative information, there is only very limited understanding of the mechanisms of these effects of heavy ions. It remains to be discovered how heavy ions cause various biological effects and why heavy ions can be so effective in producing these effects. As the understanding of molecular effects of heavy ion increases, the potential use of heavy ions in probing molecular mechanism(s) of mutation and neoplastic cell transformation becomes more evident. The exciting progress of heavy ion research in past decades only leads to more challenging questions. Answers for these interesting questions can be obtained by developing new heavy ion facilities for single particle irradiation, by further studies with modern molecular biology techniques, and by innovative approaches. Knowledge from biomedical heavy ion research will not only enhance our basic understanding of fundamental biological processes, such as repair, cell growth control, differentiation, etc., but also help in assessing health risk of space radiation and in improving animal and plant breeding. Research in heavy ion radiobiology is gradually growing from infant to mature stage. (author)

  16. The effect of modularity representation and presentation medium on the understandability of business process models in BPMN

    NARCIS (Netherlands)

    Turetken, Oktay; Rompen, Tessa; Vanderfeesten, Irene; Dikici, Ahmet; van Moll, Jan; La Rosa, M.; Loos, P.; Pastor, O.

    2016-01-01

    Many factors influence the creation of understandable business process models for an appropriate audience. Understandability of process models becomes critical particularly when a process is complex and its model is large in structure. Using modularization to represent such models hierarchically

  17. Multiscale numerical study on ferroelectric nonlinear response of PZT thin films (Conference Presentation)

    Science.gov (United States)

    Wakabayashi, Hiroki; Uetsuji, Yasutomo; Tsuchiya, Kazuyoshi

    2017-06-01

    PZT thin films have excellent performance in deformation precision and response speed, so it is used widely for actuators and sensors of Micro Electro Mechanical System (MEMS). Although PZT thin films outputs large piezoelectricity at morphotropic phase bounfary (MPB), it shows a complicated hysteresis behavior caused by domain switching and structural phase transition between tetragonal and rhombohedral. In general, PZT thin films have some characteristic crystal morphologies. Additionally mechanical strains occur by lattice mismatch with substrate. Therefore it is important for fabrication and performance improvement of PZT thin films to understand the relation between macroscopic hysteresis response and microstructural changes. In this study, a multiscale nonlinear finite element simulation was proposed for PZT thin films at morphotropic phase boundary (MPB) on the substrate. The homogenization theory was employed for scale-bridging between macrostructure and microstructure. Figure 1 shows the proposed multiscale nonlinear simulation [1-3] based on the homogenization theory. Macrostructure is a homogeneous structure to catch the whole behaviors of actuators and sensors. And microstructure is a periodic inhomogeneous structure consisting of domains and grains. Macrostructure and microstructure are connected perfectly by homogenization theory and are analyzed by finite element method. We utilized an incremental form of fundamental constitutive law in consideration with physical property change caused by domain switching and structural phase transition. The developed multiscale finite element method was applied to PZT thin films with lattice mismatch strain on the substrate, and the relation between the macroscopic hysteresis response and microscopic domain switching and structural phase transition were investigated. Especially, we discuss about the effect of crystal morphologies and lattice mismatch strain on hysteresis response.

  18. A modeling and control framework for operating large-scale electric power systems under present and newly evolving competitive industry structures

    Directory of Open Access Journals (Sweden)

    Marija D. Ilić

    1995-01-01

    Full Text Available This paper introduces a systematic, structure-based modeling framework for analysis and control of electric power systems for processes evolving over the mid-term and long-term time horizons. Much simpler models than the detailed dynamics specifically for control design at different hierarchical levels are obtained by applying both temporal and spatial separation. These simple models, or the aggregate models, represent the net effect of interactions among interconnected regions on specific hierarchical levels. They are exact, since no assumptions on weak interconnections among the subsystems are made. Moreover they are easily understood in terms of power flows among the regions. The approach is essential for improving present performance of the system. It is also potentially useful in a competitive utility environment in which it is critical to study the interplay between technical and economic processes.

  19. Imitation Modeling and Institutional Studies

    Directory of Open Access Journals (Sweden)

    Maksim Y. Barbashin

    2017-09-01

    Full Text Available This article discusses the use of imitation modeling in the conduct of institutional research. The institutional approach is based on the observation of social behavior. To understand a social process means to determine the key rules that individuals use, undertaking social actions associated with this process or phenomenon. This does not mean that institutions determine behavioral reactions, although there are a number of social situations where the majority of individuals follow the dominant rules. If the main laws of development of the institutional patterns are known, one can describe most of the social processes accurately. The author believes that the main difficulty with the analysis of institutional processes is their recursive nature: from the standards of behavior one may find the proposed actions of social agents who follow, obey or violate institutions, but the possibility of reconstructive analysis is not obvious. The author demonstrates how the institutional approach is applied to the analysis of social behavior. The article describes the basic principles and methodology of imitation modeling. Imitation modeling reveals the importance of institutions in structuring social transactions. The article concludes that in the long term institutional processes are not determined by initial conditions.

  20. Modeling of the vapor cycle of Laguna Verde with the PEPSE code to conditions of thermal power licensed at present (2027 MWt)

    International Nuclear Information System (INIS)

    Castaneda G, M. A.; Maya G, F.; Medel C, J. E.; Cardenas J, J. B.; Cruz B, H. J.; Mercado V, J. J.

    2011-11-01

    By means of the use of the performance evaluation of power system efficiencies (PEPSE) code was modeled the vapor cycle of the nuclear power station of Laguna Verde to reproduce the nuclear plant behavior to conditions of thermal power, licensed at present (2027 MWt); with the purpose of having a base line before the implementation of the project of extended power increase. The model of the gauged vapor cycle to reproduce the nuclear plant conditions makes use of the PEPSE model, design case of the vapor cycle of nuclear power station of Laguna Verde, which has as main components of the model the great equipment of the vapor cycle of Laguna Verde. The design case model makes use of information about the design requirements of each equipment for theoretically calculating the electric power of exit, besides thermodynamic conditions of the vapor cycle in different points. Starting from the design model and making use of data of the vapor cycle measured in the nuclear plant; the adjustment factors were calculated for the different equipment s of the vapor cycle, to reproduce with the PEPSE model the real vapor cycle of Laguna Verde. Once characterized the model of the vapor cycle of Laguna Verde, we can realize different sensibility studies to determine the effects macros to the vapor cycle by the variation of certain key parameters. (Author)

  1. Variability of the 2014-present inflation source at Mauna Loa volcano revealed using time-dependent modeling

    Science.gov (United States)

    Johanson, I. A.; Miklius, A.; Okubo, P.; Montgomery-Brown, E. K.

    2017-12-01

    Mauna Loa volcano is the largest active volcano on earth and in the 20thcentury produced roughly one eruption every seven years. The 33-year quiescence since its last eruption 1984 has been punctuated by three inflation episodes where magma likely entered the shallow plumbing system, but was not erupted. The most recent began in 2014 and is ongoing. Unlike prior inflation episodes, the current one is accompanied by a significant increase in shallow seismicity, a pattern that is similar to earlier pre-eruptive periods. We apply the Kalman filter based Network Inversion Filter (NIF) to the 2014-present inflation episode using data from a 27 station continuous GPS network on Mauna Loa. The model geometry consists of a point volume source and tabular, dike-like body, which have previously been shown to provide a good fit to deformation data from a 2004-2009 inflation episode. The tabular body is discretized into 1km x 1km segments. For each day, the NIF solves for the rates of opening on the tabular body segments (subject to smoothing and positivity constraints), volume change rate in the point source, and slip rate on a deep décollement fault surface, which is constrained to a constant (no transient slip allowed). The Kalman filter in the NIF provides for smoothing both forwards and backwards in time. The model shows that the 2014-present inflation episode occurred as several sub-events, rather than steady inflation. It shows some spatial variability in the location of the inflation sub-events. In the model, opening in the tabular body is initially concentrated below the volcano's summit, in an area roughly outlined by shallow seismicity. In October, 2015 opening in the tabular body shifts to be centered beneath the southwest portion of the summit and seismicity becomes concentrated in this area. By late 2016, the opening rate on the tabular body decreases and is once again under the central part of summit. This modeling approach has allowed us to track these

  2. Studying shocks in model astrophysical flows

    International Nuclear Information System (INIS)

    Chakrabarti, S.K.

    1989-01-01

    We briefly discuss some properties of the shocks in the existing models for quasi two-dimensional astrophysical flows. All of these models which allow the study of shock analytically have some unphysical characteristics due to inherent assumptions made. We propose a hybrid model for a thin flow which has fewer unpleasant features and is suitable for the study of shocks. (author). 5 refs

  3. Euroconference on the appropriate modellings of galaxy evolution from their cosmological formation to their presently observable structures

    CERN Document Server

    Stasińska, Grażyna; Harfst, Stefan; Kroupa, Pavel; Theis, Christian; THE EVOLUTION OF GALAXIES

    2003-01-01

    Galaxies have a history This has become clear from recent sky surveys which have shown that distant galaxies, formed early in the life of the Universe, differ from the nearby ones New observational windows at ultraviolet, infrared and millimetric wavelengths (provided by ROSAT, IRAM, IUE, IRAS, ISO) have revealed that galaxies contain a wealth of components very hot gas, atomic hydrogen, molecules, dust, dark matter A significant advance is expected from the results of new instruments (VLT, FIRST, XMM) which will allow one to explore the most distant Universe Three Euroconferences were planned to punctuate this new epoch in galactic research, bringing together specialists in various fields of Astronomy This book contains the proceedings of the third conference and presents the actual state-of-the-art of modelling galaxy evolution

  4. Operations planning simulation: Model study

    Science.gov (United States)

    1974-01-01

    The use of simulation modeling for the identification of system sensitivities to internal and external forces and variables is discussed. The technique provides a means of exploring alternate system procedures and processes, so that these alternatives may be considered on a mutually comparative basis permitting the selection of a mode or modes of operation which have potential advantages to the system user and the operator. These advantages are measurements is system efficiency are: (1) the ability to meet specific schedules for operations, mission or mission readiness requirements or performance standards and (2) to accomplish the objectives within cost effective limits.

  5. Evaluation of a present-day climate simulation with a new coupled atmosphere-ocean model GENMOM

    Directory of Open Access Journals (Sweden)

    J. R. Alder

    2011-02-01

    Full Text Available We present a new, non-flux corrected AOGCM, GENMOM, that combines the GENESIS version 3 atmospheric GCM (Global Environmental and Ecological Simulation of Interactive Systems and MOM2 (Modular Ocean Model version 2 nominally at T31 resolution. We evaluate GENMOM by comparison with reanalysis products (e.g., NCEP2 and three models used in the IPCC AR4 assessment. GENMOM produces a global temperature bias of 0.6 °C. Atmospheric features such as the jet stream structure and major semi-permanent sea level pressure centers are well simulated as is the mean planetary-scale wind structure that is needed to produce the correct position of stormtracks. Most ocean surface currents are reproduced except where they are not resolvable at T31 resolution. Overall, GENMOM captures reasonably well the observed gradients and spatial distributions of annual surface temperature and precipitation and the simulations are on par with other AOGCMs. Deficiencies in the GENMOM simulations include a warm bias in the surface temperature over the southern oceans, a split in the ITCZ and weaker-than-observed overturning circulation.

  6. Delivery presentations

    Science.gov (United States)

    Pregnancy - delivery presentation; Labor - delivery presentation; Occiput posterior; Occiput anterior; Brow presentation ... The mother can walk, rock, and try different delivery positions during labor to help encourage the baby ...

  7. Unmatched Case-Control Study on Late Presentation of HIV Infection in Santiago, Cape Verde (2004-2011).

    Science.gov (United States)

    Moreira, António L; Fronteira, Inês; Augusto, Gonçalo Figueiredo; Martins, Maria Rosario O

    2016-03-15

    Access to free antiretroviral therapy (ART) in Sub-Saharan Africa has been steadily increasing over the past decade. However, the success of large-scale ART programmes depends on timely diagnosis and early initiation of HIV care. This study characterizes late presenters to HIV care in Santiago (Cape Verde) between 2004 and 2011, and identifies factors associated with late presentation for care. We defined late presentation as persons presenting to HIV care with a CD4 count below 350 cells/mm³. An unmatched case-control study was conducted using socio-demographic and behavioural data of 368 individuals (191 cases and 177 controls) collected through an interviewer-administered questionnaire, comparing HIV patients late and early presented to care. Logistic regression was performed to estimate odds ratio and 95% confidence intervals. Results show that 51.9% were late presenters for HIV. No differences were found in gender distribution, marital status, or access to health services between cases and controls. Participants who undertook an HIV test by doctor indication were more likely to present late compared with those who tested for HIV by their own initiative. Also, individuals taking less time to initiate ART are more likely to present late. This study highlights the need to better understand reasons for late presentation to HIV care in Cape Verde. People in older age groups should be targeted in future approaches focused on late presenters to HIV care.

  8. Unmatched Case-Control Study on Late Presentation of HIV Infection in Santiago, Cape Verde (2004–2011)

    Science.gov (United States)

    Moreira, António L.; Fronteira, Inês; Augusto, Gonçalo Figueiredo; Martins, Maria Rosario O.

    2016-01-01

    Access to free antiretroviral therapy (ART) in Sub-Saharan Africa has been steadily increasing over the past decade. However, the success of large-scale ART programmes depends on timely diagnosis and early initiation of HIV care. This study characterizes late presenters to HIV care in Santiago (Cape Verde) between 2004 and 2011, and identifies factors associated with late presentation for care. We defined late presentation as persons presenting to HIV care with a CD4 count below 350 cells/mm3. An unmatched case-control study was conducted using socio-demographic and behavioural data of 368 individuals (191 cases and 177 controls) collected through an interviewer-administered questionnaire, comparing HIV patients late and early presented to care. Logistic regression was performed to estimate odds ratio and 95% confidence intervals. Results show that 51.9% were late presenters for HIV. No differences were found in gender distribution, marital status, or access to health services between cases and controls. Participants who undertook an HIV test by doctor indication were more likely to present late compared with those who tested for HIV by their own initiative. Also, individuals taking less time to initiate ART are more likely to present late. This study highlights the need to better understand reasons for late presentation to HIV care in Cape Verde. People in older age groups should be targeted in future approaches focused on late presenters to HIV care. PMID:26999167

  9. European-wide simulations of present cropland phenology, productivity and carbon fluxes using an improved terrestrial biosphere model

    Science.gov (United States)

    Smith, P. C.; Ciais, P.; de Noblet, N.; Peylin, P.; Viovy, N.; Bondeau, A.

    2009-04-01

    Aiming at producing improved estimates of carbon source/sink spatial and interannual patterns across Europe (35% croplands), this work combines the terrestrial biosphere model ORCHIDEE (for vegetation productivity, water balance, soil carbon dynamics) and the generic crop model STICS (for phenology, irrigation, nitrogen balance, harvest). The ORCHIDEE-STICS model, relying on three plant functional types for the representation of temperate agriculture, is evaluated over the last few decades at various spatial and temporal resolutions. The simulated Leaf Area Index seasonal cycle is largely improved relative to the original ORCHIDEE simulating grasslands, and compares favourably with remote-sensing observations (the Figure of Merit in Time doubles over Europe). Crop yield is derived from annual Net Primary Productivity and compared with wheat and grain maize harvest data for five European countries. Discrepancies between 30-year mean simulated and reported yields remain large in Mediterranean countries. Interannual variability amplitude expressed relative to the mean is reduced towards the observed variability (~10%) when using ORCHIDEE-STICS. The simulated 2003 anomalous carbon source from European ecosystems to the atmosphere due to the 2003 summer heat wave is in good agreement with atmospheric inversions (~0.2 GtC, from May to October). The anomaly is twice as large in the ORCHIDEE alone simulation, owing to the unrealistically high exposure of herbaceous plants to the extreme summer conditions. Overall, this study highlights the importance of accounting for the specific phonologies of crops sown both in winter and in spring and for irrigation applied to summer crops in regional/global models of the terrestrial carbon cycle. Limitations suggest accounting for temporal and spatial variability in agricultural practices for further simulation improvement.

  10. Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study

    Science.gov (United States)

    Trotta, Antonella; Iyegbe, Conrad; Di Forti, Marta; Sham, Pak C.; Campbell, Desmond D.; Cherny, Stacey S.; Mondelli, Valeria; Aitchison, Katherine J.; Murray, Robin M.

    2016-01-01

    A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to number or severity of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing genetic vulnerability. Research on gene-environment interaction in psychosis has primarily focused on candidate genes, although the genetic effects are now known to be polygenic. This pilot study investigated whether the effect of childhood adversity on psychosis is moderated by the polygenic risk score for schizophrenia (PRS). Data were utilised from the Genes and Psychosis (GAP) study set in South London, UK. The GAP sample comprises 285 first-presentation psychosis cases and 256 unaffected controls with information on childhood adversity. We studied only white subjects (80 cases and 110 controls) with PRS data, as the PRS has limited predictive ability in patients of African ancestry. The occurrence of childhood adversity was assessed with the Childhood Experience of Care and Abuse Questionnaire (CECA.Q) and the PRS was based on genome-wide meta-analysis results for schizophrenia from the Psychiatric Genomics Consortium. Higher schizophrenia PRS and childhood adversities each predicted psychosis status. Nevertheless, no evidence was found for interaction as departure from additivity, indicating that the effect of polygenic risk scores on psychosis was not increased in the presence of a history of childhood adversity. These findings are compatible with a multifactorial threshold model in which both genetic liability and exposure to environmental risk contribute independently to the etiology of psychosis. PMID:27648571

  11. Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study.

    Science.gov (United States)

    Trotta, Antonella; Iyegbe, Conrad; Di Forti, Marta; Sham, Pak C; Campbell, Desmond D; Cherny, Stacey S; Mondelli, Valeria; Aitchison, Katherine J; Murray, Robin M; Vassos, Evangelos; Fisher, Helen L

    2016-01-01

    A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to number or severity of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing genetic vulnerability. Research on gene-environment interaction in psychosis has primarily focused on candidate genes, although the genetic effects are now known to be polygenic. This pilot study investigated whether the effect of childhood adversity on psychosis is moderated by the polygenic risk score for schizophrenia (PRS). Data were utilised from the Genes and Psychosis (GAP) study set in South London, UK. The GAP sample comprises 285 first-presentation psychosis cases and 256 unaffected controls with information on childhood adversity. We studied only white subjects (80 cases and 110 controls) with PRS data, as the PRS has limited predictive ability in patients of African ancestry. The occurrence of childhood adversity was assessed with the Childhood Experience of Care and Abuse Questionnaire (CECA.Q) and the PRS was based on genome-wide meta-analysis results for schizophrenia from the Psychiatric Genomics Consortium. Higher schizophrenia PRS and childhood adversities each predicted psychosis status. Nevertheless, no evidence was found for interaction as departure from additivity, indicating that the effect of polygenic risk scores on psychosis was not increased in the presence of a history of childhood adversity. These findings are compatible with a multifactorial threshold model in which both genetic liability and exposure to environmental risk contribute independently to the etiology of psychosis.

  12. STRESS RESPONSE STUDIES USING ANIMAL MODELS

    Science.gov (United States)

    This presentation will provide the evidence that ozone exposure in animal models induce neuroendocrine stress response and this stress response modulates lung injury and inflammation through adrenergic and glucocorticoid receptors.

  13. A study on an optimal movement model

    Energy Technology Data Exchange (ETDEWEB)

    Feng Jianfeng [COGS, Sussex University, Brighton BN1 9QH, UK (United Kingdom); Zhang, Kewei [SMS, Sussex University, Brighton BN1 9QH (United Kingdom); Luo Yousong [Department of Mathematics and Statistics, RMIT University, GOP Box 2476V, Melbourne, Vic 3001 (Australia)

    2003-07-11

    We present an analytical and rigorous study on a TOPS (task optimization in the presence of signal-dependent noise) model with a hold-on or an end-point control. Optimal control signals are rigorously obtained, which enables us to investigate various issues about the model including its trajectories, velocities, control signals, variances and the dependence of these quantities on various model parameters. With the hold-on control, we find that the optimal control can be implemented with an almost 'nil' hold-on period. The optimal control signal is a linear combination of two sub-control signals. One of the sub-control signals is positive and the other is negative. With the end-point control, the end-point variance is dramatically reduced, in comparison with the hold-on control. However, the velocity is not symmetric (bell shape). Finally, we point out that the velocity with a hold-on control takes the bell shape only within a limited parameter region.

  14. Choosing between responsive-design websites versus mobile apps for your mobile behavioral intervention: presenting four case studies.

    Science.gov (United States)

    Turner-McGrievy, Gabrielle M; Hales, Sarah B; Schoffman, Danielle E; Valafar, Homay; Brazendale, Keith; Weaver, R Glenn; Beets, Michael W; Wirth, Michael D; Shivappa, Nitin; Mandes, Trisha; Hébert, James R; Wilcox, Sara; Hester, Andrew; McGrievy, Matthew J

    2017-06-01

    Both mobile apps and responsive-design websites (web apps) can be used to deliver mobile health (mHealth) interventions, but it can be difficult to discern which to use in research. The goal of this paper is to present four case studies from behavioral interventions that developed either a mobile app or a web app for research and present an information table to help researchers determine which mobile option would work best for them. Four behavioral intervention case studies (two developed a mobile app, and two developed a web app) presented include time, cost, and expertise. Considerations for adopting a mobile app or a web app-such as time, cost, access to programmers, data collection, security needs, and intervention components- are presented. Future studies will likely integrate both mobile app and web app modalities. The considerations presented here can help guide researchers on which platforms to choose prior to starting an mHealth intervention.

  15. Human urine-based therapeutics in Spain from the early 20th century to the present: a historical literature overview and a present-day case study.

    Science.gov (United States)

    Vallejo, José Ramón; Aparicio Mena, Alfonso J; González, José Antonio

    2017-06-01

    Human urine is currently the subject of biomedical investigations as a potential therapeutic resource and it continues to be used in remedies in different cultures and societies, including the Spanish culture. In this study we gather etnomedical knowledge about urotherapy and determine their associated symbolisms in Spain. A literature overview and a case study were carried out to compile urine-based remedies and as a direct analysis of symbolic systems. Urotherapy is widespread in Spanish folk medicine. Among the 204 collected remedies, those related to treatment of diseases or skin conditions predominate (63%). Remedies have been reported for the treatment of skin diseases such as eczema, chloasma, alopecia, etc. to treat or alleviate burns, chilblains, wounds or skin chapping, and as a treatment of venomous bites. Most of the collected remedies have an associated naturalist symbolism, based on local traditions and the transmission of empirical initial knowledge. The use of urine in Spain is a result of the interaction of two types of practice: a local and traditional urotherapy, rural and with a utilitarian purpose, and a technical urotherapy, limited to an urban environment and a naturopathic medicine.

  16. Neuropsychological and Behavioural Phenotype of Dandy-Walker Variant Presenting in Chromosome 22 Trisomy: A Case Study

    Science.gov (United States)

    Searson, Ruth; Hare, Dougal Julian; Sridharan, Sridhar

    2013-01-01

    In this study, a case of Dandy-Walker variant syndrome associated with trisomy 22 in a 17-year-old man is described. This is the first account of this combination in a person surviving into adulthood, and the neuropsychological and behavioural presentation is described in detail and a clinical formulation is presented for the benefit of…

  17. Paleohistology and the study of human remains: past, present and future approaches / La paleohistologia y el estudio de restos humanos: aproximaciones pasadas presentes y futuras

    Directory of Open Access Journals (Sweden)

    Sandra Assis

    2015-12-01

    Full Text Available The invention of the microscope revolutionized the course of human knowledge. This instrument changed the face of science and of previous beliefs, expanded the horizons of knowledge, and challenged philosophical and scientific thought, especially in the field of natural sciences and medicine. In the domain of bioarchaeology, the introduction of histological techniques was important; not only to identify body tissues and to diagnose diseases in mummified remains, but also to understand bone and teeth microstructure, and associated patterns of response to environmental constraints. In this paper a critical review of the major contributions of histology to the growing body of knowledge in paleopathology and bioarchaeology will be presented, focusing on the current multiple applications of microscopy, its limitations, and its future challenges. KEY WORDS microscopy; dry bone remains; multiple approaches   La invención del microscopio ha revolucionado el curso del conocimiento humano. Este instrumento cambió la “cara” de la ciencia y de las creencias anteriores, amplió los horizontes del conocimiento y retó al pensamiento filosófico y científico, especialmente en el campo de las ciencias naturales y la medicina. En el dominio de la bioarqueología, la introducción de técnicas histológicas fue determinante, no sólo para identificar los tejidos del cuerpo y diagnosticar enfermedades en restos momificados, sino también para comprender la microestructura y dinámica de los huesos y los dientes, y los patrones asociados de respuesta a las restricciones ambientales. En este trabajo se presenta una revisión crítica de las principales contribuciones de la histología al creciente cuerpo de conocimientos de la paleopatología y la bioarqueología, con énfasis en las actuales aplicaciones de la microscopía, sus limitaciones y los desafíos para el futuro. PALABRAS CLAVE microscopía, restos humanos, múltiples enfoques

  18. Webinar Presentation: Air Pollution, Social and Psychosocial Stress, and Respitory Health in the Southern California Children's Health Study

    Science.gov (United States)

    This presentation, Air Pollution, Social and Psychosocial Stress, and Respitory Health in the Southern California Children's Health Study, was given at the NIEHS/EPA Children's Centers 2016 Webinar Series: Exposome held on May 11, 2016.

  19. Comparative study between Steiner's cephalometric-radiographic patterns and the ones of Brazilian's, white teenagers, who present normal occlusion

    International Nuclear Information System (INIS)

    Domingues, A.P. de.

    1986-01-01

    The purpose of this study was to study comparatively the cephalometric-radiographic patterns of Steiner's analysis and the ones of Brazilians, white teenagers, who present normal occlusions. The sample was composed of fifty seven teleradiographies on lateral pattern from Brazilian teenagers. Those teenagers are white and their parents are Brazilian, descended from Mediterraneans. Also the examined teenagers had not undergone previous orthodontic treatment and as it was said above, present normal occlusion. (author) [pt

  20. Review on present state of human model researches in nuclear engineering and the prospect for their industrial applications

    International Nuclear Information System (INIS)

    Yoshikawa, Hidekazu; Furuta, Kazuo; Nakagawa, Tsuneo; Yoshimura, Seiichi; Yoshida, Kazuo; Naito, Norio

    1999-01-01

    Reviews have been made on the researches and developments for human models in the field of nuclear engineering. Until now, the related works have been made mainly for the modeling of plant operator and operator crew in the control room, but also there arise new tendencies of extending the modeling works for maintenance field as well as for personnel training purposes. The whole range of human model research is divided into the five areas of (a) modeling for machine system, (b) measurement and analysis of human information behavior, (c) modeling of human internal information process, (d) modeling of human interaction with machine system, and (e) that of between human themselves. The real examples of the human model developments as well as their methods, applications, and the model validations are described, and then, the further subjects and efforts are pointed out which would be needed for the broader industrial application of the human modeling. (author)