WorldWideScience

Sample records for model simple cells

  1. The curvature calculation mechanism based on simple cell model.

    Science.gov (United States)

    Yu, Haiyang; Fan, Xingyu; Song, Aiqi

    2017-07-20

    A conclusion has not yet been reached on how exactly the human visual system detects curvature. This paper demonstrates how orientation-selective simple cells can be used to construct curvature-detecting neural units. Through fixed arrangements, multiple plurality cells were constructed to simulate curvature cells with a proportional output to their curvature. In addition, this paper offers a solution to the problem of narrow detection range under fixed resolution by selecting an output value under multiple resolution. Curvature cells can be treated as concrete models of an end-stopped mechanism, and they can be used to further understand "curvature-selective" characteristics and to explain basic psychophysical findings and perceptual phenomena in current studies.

  2. A CORF computational model of a simple cell that relies on LGN input outperforms the Gabor function model

    NARCIS (Netherlands)

    Azzopardi, George; Petkov, Nicolai

    Simple cells in primary visual cortex are believed to extract local contour information from a visual scene. The 2D Gabor function (GF) model has gained particular popularity as a computational model of a simple cell. However, it short-cuts the LGN, it cannot reproduce a number of properties of real

  3. A simple model of space radiation damage in GaAs solar cells

    Science.gov (United States)

    Wilson, J. W.; Stith, J. J.; Stock, L. V.

    1983-01-01

    A simple model is derived for the radiation damage of shallow junction gallium arsenide (GaAs) solar cells. Reasonable agreement is found between the model and specific experimental studies of radiation effects with electron and proton beams. In particular, the extreme sensitivity of the cell to protons stopping near the cell junction is predicted by the model. The equivalent fluence concept is of questionable validity for monoenergetic proton beams. Angular factors are quite important in establishing the cell sensitivity to incident particle types and energies. A fluence of isotropic incidence 1 MeV electrons (assuming infinite backing) is equivalent to four times the fluence of normal incidence 1 MeV electrons. Spectral factors common to the space radiations are considered, and cover glass thickness required to minimize the initial damage for a typical cell configuration is calculated. Rough equivalence between the geosynchronous environment and an equivalent 1 MeV electron fluence (normal incidence) is established.

  4. Simple Cell Balance Circuit

    Science.gov (United States)

    Johnson, Steven D.; Byers, Jerry W.; Martin, James A.

    2012-01-01

    A method has been developed for continuous cell voltage balancing for rechargeable batteries (e.g. lithium ion batteries). A resistor divider chain is provided that generates a set of voltages representing the ideal cell voltage (the voltage of each cell should be as if the cells were perfectly balanced). An operational amplifier circuit with an added current buffer stage generates the ideal voltage with a very high degree of accuracy, using the concept of negative feedback. The ideal voltages are each connected to the corresponding cell through a current- limiting resistance. Over time, having the cell connected to the ideal voltage provides a balancing current that moves the cell voltage very close to that ideal level. In effect, it adjusts the current of each cell during charging, discharging, and standby periods to force the cell voltages to be equal to the ideal voltages generated by the resistor divider. The device also includes solid-state switches that disconnect the circuit from the battery so that it will not discharge the battery during storage. This solution requires relatively few parts and is, therefore, of lower cost and of increased reliability due to the fewer failure modes. Additionally, this design uses very little power. A preliminary model predicts a power usage of 0.18 W for an 8-cell battery. This approach is applicable to a wide range of battery capacities and voltages.

  5. Improved CORF model of simple cell combined with non-classical receptive field and its application on edge detection

    Science.gov (United States)

    Sun, Xiao; Chai, Guobei; Liu, Wei; Bao, Wenzhuo; Zhao, Xiaoning; Ming, Delie

    2018-02-01

    Simple cells in primary visual cortex are believed to extract local edge information from a visual scene. In this paper, inspired by different receptive field properties and visual information flow paths of neurons, an improved Combination of Receptive Fields (CORF) model combined with non-classical receptive fields was proposed to simulate the responses of simple cell's receptive fields. Compared to the classical model, the proposed model is able to better imitate simple cell's physiologic structure with consideration of facilitation and suppression of non-classical receptive fields. And on this base, an edge detection algorithm as an application of the improved CORF model was proposed. Experimental results validate the robustness of the proposed algorithm to noise and background interference.

  6. Random blebbing motion: A simple model linking cell structural properties to migration characteristics

    Science.gov (United States)

    Woolley, Thomas E.; Gaffney, Eamonn A.; Goriely, Alain

    2017-07-01

    If the plasma membrane of a cell is able to delaminate locally from its actin cortex, a cellular bleb can be produced. Blebs are pressure-driven protrusions, which are noteworthy for their ability to produce cellular motion. Starting from a general continuum mechanics description, we restrict ourselves to considering cell and bleb shapes that maintain approximately spherical forms. From this assumption, we obtain a tractable algebraic system for bleb formation. By including cell-substrate adhesions, we can model blebbing cell motility. Further, by considering mechanically isolated blebbing events, which are randomly distributed over the cell, we can derive equations linking the macroscopic migration characteristics to the microscopic structural parameters of the cell. This multiscale modeling framework is then used to provide parameter estimates, which are in agreement with current experimental data. In summary, the construction of the mathematical model provides testable relationships between the bleb size and cell motility.

  7. Simple inflationary quintessential model

    Science.gov (United States)

    de Haro, Jaume; Amorós, Jaume; Pan, Supriya

    2016-04-01

    In the framework of a flat Friedmann-Lemaître-Robertson-Walker geometry, we present a non-geodesically past complete model of our Universe without the big bang singularity at finite cosmic time, describing its evolution starting from its early inflationary era up to the present accelerating phase. We found that a hydrodynamical fluid with nonlinear equation of state could result in such scenario, which after the end of this inflationary stage, suffers a sudden phase transition and enters into the stiff matter dominated era, and the Universe becomes reheated due to a huge amount of particle production. Finally, it asymptotically enters into the de Sitter phase concluding the present accelerated expansion. Using the reconstruction technique, we also show that this background provides an extremely simple inflationary quintessential potential whose inflationary part is given by the well-known 1-dimensional Higgs potential, i.e., a double well inflationary potential, and the quintessential one by an exponential potential that leads to a deflationary regime after this inflation, and it can depict the current cosmic acceleration at late times. Moreover the Higgs potential leads to a power spectrum of the cosmological perturbations which fit well with the latest Planck estimations. Further, we compared our viable potential with some known inflationary quintessential potential, which shows that our quintessential model, that is, the Higgs potential combined with the exponential one, is an improved version of them because it contains an analytic solution that allows us to perform all analytic calculations. Finally, we have shown that the introduction of a nonzero cosmological constant simplifies the potential considerably with an analytic behavior of the background which again permits us to evaluate all the quantities analytically.

  8. SIMPLE MODELS OF COMPLEX BEHAVIOUR

    Indian Academy of Sciences (India)

    SIMPLE MODELS OF COMPLEX BEHAVIOUR · COMPLEXITY IN HUMAN AFFAIRS · COMPLEXITY IN STATISTICAL PHYSICS · DISORDER, CRITICALITY and ORDER IN EQUILIBRIUM SYSTEMS · COARSENING PHENOMENA · NONEQUILIBRIUM STEADY STATES · ORDERING INDUCED BY RANDOM DRIVING.

  9. Model pseudopotential in simple metals

    International Nuclear Information System (INIS)

    Khanna, K.N.; Sharma, P.K.

    1980-01-01

    The model potential proposed by Sharma and Srivastava has been used to study the various properties of simple metals. New core radii have also been reported corresponding to three dielectric functions. For most metals, the model potential successfully describes the atomic properties. (author)

  10. Two Simple Models for Fracking

    Science.gov (United States)

    Norris, Jaren Quinn

    Recent developments in fracking have enable the recovery of oil and gas from tight shale reservoirs. These developments have also made fracking one of the most controversial environmental issues in the United States. Despite the growing controversy surrounding fracking, there is relatively little publicly available research. This dissertation introduces two simple models for fracking that were developed using techniques from non-linear and statistical physics. The first model assumes that the volume of induced fractures must be equal to the volume of injected fluid. For simplicity, these fractures are assumed to form a spherically symmetric damage region around the borehole. The predicted volumes of water necessary to create a damage region with a given radius are in good agreement with reported values. The second model is a modification of invasion percolation which was previously introduced to model water flooding. The reservoir rock is represented by a regular lattice of local traps that contain oil and/or gas separated by rock barriers. The barriers are assumed to be highly heterogeneous and are assigned random strengths. Fluid is injected from a central site and the weakest rock barrier breaks allowing fluid to flow into the adjacent site. The process repeats with the weakest barrier breaking and fluid flowing to an adjacent site each time step. Extensive numerical simulations were carried out to obtain statistical properties of the growing fracture network. The network was found to be fractal with fractal dimensions differing slightly from the accepted values for traditional percolation. Additionally, the network follows Horton-Strahler and Tokunaga branching statistics which have been used to characterize river networks. As with other percolation models, the growth of the network occurs in bursts. These bursts follow a power-law size distribution similar to observed microseismic events. Reservoir stress anisotropy is incorporated into the model by assigning

  11. Simple model for molecular scattering

    Science.gov (United States)

    Mehta, Nirav; Ticknor, Christopher; Hazzard, Kaden

    2017-04-01

    The collisions of ultracold molecules are qualitatively different from the collisions of ultracold atoms due to the high density of bimolecular resonances near the collision energy. We present results from a simple N-channel scattering model with square-well channel potentials and constant channel couplings (inside the well) designed to reproduce essential features of chaotic molecular scattering. The potential depths and channel splittings are tuned to reproduce the appropriate density of states for the short-range bimolecular collision complex (BCC), which affords a direct comparison of the resulting level-spacing distribution to that expected from random matrix theory (RMT), namely the so-called Wigner surmise. The density of states also sets the scale for the rate of dissociation from the BCC to free molecules, as approximated by transition state theory (TST). Our model affords a semi-analytic solution for the scattering amplitude in the open channel, and a determinantal equation for the eigenenergies of the short-ranged BCC. It is likely the simplest finite-ranged scattering model that can be compared to expectations from the approximations of RMT, and TST. The validity of these approximations has implications for the many-channel Hubbard model recently developed. This research was funded in part by the National Science Foundation under Grant No. NSF PHY-1125915.

  12. Simple model for dice loading

    Science.gov (United States)

    Nagler, Jan; Richter, Peter H.

    2010-03-01

    Dice tossing is commonly believed to be random. However, throwing a fair cube is a dissipative process that is well described by deterministic classical mechanics. In Nagler and Richter (2008 Phys. Rev. E 78 036207; featured in 2008 Nature 455 434), we proposed a simplified model to analyze the origin of the pseudorandomness: a barbell with two masses at its tips with only two final outcomes. In order to keep things simple, we focused on the symmetrical case of equal masses. Here, we complete the picture by considering the general asymmetric case of unequal masses. We show how, depending on the initial conditions, dissipation during bounces, and mass asymmetry, the degree of unpredictability varies. Our analysis reveals, for the simplest possible non-trivial dice throwing model, the effect of dice loading. A surprising consequence of dynamical resonances is that an experienced player may benefit sometimes more from an unloaded than from a loaded barbell. In addition, we investigate the influence of loading on the symmetry breaking process causing one mass to come to rest earlier than the others.

  13. A Simple Model to Study Tau Pathology

    Directory of Open Access Journals (Sweden)

    Alexander L. Houck

    2016-01-01

    Full Text Available Tau proteins play a role in the stabilization of microtubules, but in pathological conditions, tauopathies, tau is modified by phosphorylation and can aggregate into aberrant aggregates. These aggregates could be toxic to cells, and different cell models have been used to test for compounds that might prevent these tau modifications. Here, we have used a cell model involving the overexpression of human tau in human embryonic kidney 293 cells. In human embryonic kidney 293 cells expressing tau in a stable manner, we have been able to replicate the phosphorylation of intracellular tau. This intracellular tau increases its own level of phosphorylation and aggregates, likely due to the regulatory effect of some growth factors on specific tau kinases such as GSK3. In these conditions, a change in secreted tau was observed. Reversal of phosphorylation and aggregation of tau was found by the use of lithium, a GSK3 inhibitor. Thus, we propose this as a simple cell model to study tau pathology in nonneuronal cells due to their viability and ease to work with.

  14. A Simple Demonstration Model of Osmosis

    Science.gov (United States)

    Morse, Joseph G.

    1999-01-01

    A simple device constructed from a wire screen, a large beaker, beans, and oats is described. It provides a simple and effective visual model of the phenomenon of osmosis and, by extension, the origin of other colligative properties of solutions.

  15. A simple model for straggling evaluation

    CERN Document Server

    Wilson, J W; Tai, H; Tripathi, R K

    2002-01-01

    Simple straggling models had largely been abandoned in favor of Monte Carlo simulations of straggling which are accurate but time consuming, limiting their application in practice. The difficulty of simple analytic models is the failure to give accurate values past 85% of the particle range. A simple model is derived herein based on a second order approximation upon which rapid analysis tools are developed for improved understanding of material charged particle transmission properties.

  16. Simple model for directed networks

    Science.gov (United States)

    Morelli, Luis G.

    2003-06-01

    We study a model for directed networks based on the Watts-Stogatz model for small-world phenomena. We focus on some topological aspects of directed networks inspired in food web theory, namely, the fraction of basal and top nodes in the network and node level distributions. We argue that in directed networks basal nodes play an important role, collecting information or resources from the environment. We give analytical expressions for the fraction of basal and top nodes for the model, and study the node level distributions with numerical simulations.

  17. Simple Models for Process Control

    Czech Academy of Sciences Publication Activity Database

    Gorez, R.; Klán, Petr

    2011-01-01

    Roč. 22, č. 2 (2011), s. 58-62 ISSN 0929-2268 Institutional research plan: CEZ:AV0Z10300504 Keywords : process models * PID control * second order dynamics Subject RIV: JB - Sensors, Measurment, Regulation

  18. IEEE 802.11 Networks: A Simple Model Geared Towards Offloading Studies and Considerations on Future Small Cells

    DEFF Research Database (Denmark)

    Garcia, Luis Guilherme Uzeda; Rodriguez, Ignacio; Catania, Davide

    2013-01-01

    WiFi is the prevalent wireless access technology in local area deployments and is expected to play a major role in a mobile operator’s data offloading strategy. As a result, having simple tools that are able to assess the offloading potential of IEEE 802.11 networks is vital. In this paper, we...

  19. Length summation in simple cells of cat striate cortex.

    Science.gov (United States)

    Schumer, R A; Movshon, J A

    1984-01-01

    We have examined two models for the preference displayed by cortical simple cells for elongated stimuli having a particular orientation. Both assume that geniculate afferents with aligned receptive fields pool to form the receptive field of the cortical unit. The first model [Marr and Hildreth, Proc. R. Soc. Lond. Ser. B 200, 269-294 (1980)], includes AND gating along the length axis so that a simple cell does not fire unless a critical number of its afferents with adjacent receptive fields are firing. The second model assumes that geniculate input is simply summed over subunits and then passed through a firing threshold. Both models account for the unresponsiveness of simple cells to spots of light, but the AND model predicts a discontinuous length threshold, while the summation model predicts that length and contrast should be interchangeable in the determination of the response threshold. Experiments in which length and contrast were systematically varied support the summation model, and extend the notion of linear spatial summation to the length axis in simple cells.

  20. A simple model for binary star evolution

    International Nuclear Information System (INIS)

    Whyte, C.A.; Eggleton, P.P.

    1985-01-01

    A simple model for calculating the evolution of binary stars is presented. Detailed stellar evolution calculations of stars undergoing mass and energy transfer at various rates are reported and used to identify the dominant physical processes which determine the type of evolution. These detailed calculations are used to calibrate the simple model and a comparison of calculations using the detailed stellar evolution equations and the simple model is made. Results of the evolution of a few binary systems are reported and compared with previously published calculations using normal stellar evolution programs. (author)

  1. Simple model of stacking-fault energies

    DEFF Research Database (Denmark)

    Stokbro, Kurt; Jacobsen, Lærke Wedel

    1993-01-01

    A simple model for the energetics of stacking faults in fcc metals is constructed. The model contains third-nearest-neighbor pairwise interactions and a term involving the fourth moment of the electronic density of states. The model is in excellent agreement with recently published local-density ......A simple model for the energetics of stacking faults in fcc metals is constructed. The model contains third-nearest-neighbor pairwise interactions and a term involving the fourth moment of the electronic density of states. The model is in excellent agreement with recently published local...

  2. Foreshocks and Aftershocks in Simple Earthquake Models

    Science.gov (United States)

    Tiampo, K. F.; Klein, W.; Dominguez, R.; Kazemian, J.; González, P. J.

    2014-12-01

    Natural earthquake fault systems are highly heterogeneous in space; inhomogeneities occur because the earth is made of a variety of materials of different strengths and dissipate stress differently. Because the spatial arrangement of these materials is dependent on the geologic history, the distribution of these various materials can be quite complex and occur over a wide range of length scales. Despite their inhomogeneous nature, real faults are often modeled as spatially homogeneous systems. Here we present a simple earthquake fault model based on the Olami-Feder-Christensen (OFC) and Rundle-Jackson-Brown (RJB) cellular automata models with long-range interactions that incorporates a fixed percentage of stronger sites, or 'asperity cells', into the lattice. These asperity cells are significantly stronger than the surrounding lattice sites but eventually rupture when the applied stress reaches their higher threshold stress. The introduction of these spatial heterogeneities results in temporal clustering in the model that mimics those seen in natural fault systems. We observe sequences of activity that start with a gradually accelerating number of larger events (foreshocks) prior to a mainshock that is followed by a tail of decreasing activity (aftershocks). These recurrent large events occur at regular intervals, as is often observed in historic seismicity, and the time between events and their magnitude are a function of the stress dissipation parameter. The relative length of the foreshock to aftershock sequence depends on the amount of stress dissipation in the system, resulting in relatively long aftershock sequences when the stress dissipation is large versus long foreshock sequences when the stress dissipation is weak. This work provides further evidence that the spatial and temporal patterns observed in natural seismicity are strongly influenced by the underlying physical properties and are not solely the result of a simple cascade mechanism. We find that

  3. A Simple Model of Self-Assessments

    NARCIS (Netherlands)

    S. Dominguez Martinez (Silvia); O.H. Swank (Otto)

    2006-01-01

    textabstractWe develop a simple model that describes individuals' self-assessments of their abilities. We assume that individuals learn about their abilities from appraisals of others and experience. Our model predicts that if communication is imperfect, then (i) appraisals of others tend to be too

  4. A simple model of self-assessment

    NARCIS (Netherlands)

    Dominguez-Martinez, S.; Swank, O.H.

    2009-01-01

    We develop a simple model that describes individuals' self-assessments of their abilities. We assume that individuals learn about their abilities from appraisals of others and experience. Our model predicts that if communication is imperfect, then (i) appraisals of others tend to be too positive and

  5. A Study of Simple Diffraction Models

    DEFF Research Database (Denmark)

    Agerkvist, Finn

    In this paper two simple methods for cabinet edge diffraction are examined. Calculations with both models are compared with more sophisticated theoretical models and with measured data. The parameters involved are studied and their importance for normal loudspeaker box designs is examined....

  6. From Complex to Simple: Interdisciplinary Stochastic Models

    Science.gov (United States)

    Mazilu, D. A.; Zamora, G.; Mazilu, I.

    2012-01-01

    We present two simple, one-dimensional, stochastic models that lead to a qualitative understanding of very complex systems from biology, nanoscience and social sciences. The first model explains the complicated dynamics of microtubules, stochastic cellular highways. Using the theory of random walks in one dimension, we find analytical expressions…

  7. Teaching Alveolar Ventilation with Simple, Inexpensive Models

    Science.gov (United States)

    DiCarlo, Stephen E.

    2008-01-01

    When teaching and learning about alveolar ventilation with our class of 300 first-year medical students, we use four simple, inexpensive "models." The models, which encourage research-oriented learning and help our students to understand complex ideas, are distributed to the students before class. The students anticipate something new every day,…

  8. Simple Numerical Model of Laminated Glass Beams

    Directory of Open Access Journals (Sweden)

    A. Zemanová

    2008-01-01

    Full Text Available This paper presents a simple Finite Element model aimed at efficient simulation of layered glass units. The approach is based on considering the independent kinematics of each layer, tied together via Lagrange multipliers. Validation and verification of the resulting model against independent data demonstrate its accuracy, showing its potential for generalization towards more complex problems. 

  9. A simple model for indentation creep

    Science.gov (United States)

    Ginder, Ryan S.; Nix, William D.; Pharr, George M.

    2018-03-01

    A simple model for indentation creep is developed that allows one to directly convert creep parameters measured in indentation tests to those observed in uniaxial tests through simple closed-form relationships. The model is based on the expansion of a spherical cavity in a power law creeping material modified to account for indentation loading in a manner similar to that developed by Johnson for elastic-plastic indentation (Johnson, 1970). Although only approximate in nature, the simple mathematical form of the new model makes it useful for general estimation purposes or in the development of other deformation models in which a simple closed-form expression for the indentation creep rate is desirable. Comparison to a more rigorous analysis which uses finite element simulation for numerical evaluation shows that the new model predicts uniaxial creep rates within a factor of 2.5, and usually much better than this, for materials creeping with stress exponents in the range 1 ≤ n ≤ 7. The predictive capabilities of the model are evaluated by comparing it to the more rigorous analysis and several sets of experimental data in which both the indentation and uniaxial creep behavior have been measured independently.

  10. The Monash University Interactive Simple Climate Model

    Science.gov (United States)

    Dommenget, D.

    2013-12-01

    The Monash university interactive simple climate model is a web-based interface that allows students and the general public to explore the physical simulation of the climate system with a real global climate model. It is based on the Globally Resolved Energy Balance (GREB) model, which is a climate model published by Dommenget and Floeter [2011] in the international peer review science journal Climate Dynamics. The model simulates most of the main physical processes in the climate system in a very simplistic way and therefore allows very fast and simple climate model simulations on a normal PC computer. Despite its simplicity the model simulates the climate response to external forcings, such as doubling of the CO2 concentrations very realistically (similar to state of the art climate models). The Monash simple climate model web-interface allows you to study the results of more than a 2000 different model experiments in an interactive way and it allows you to study a number of tutorials on the interactions of physical processes in the climate system and solve some puzzles. By switching OFF/ON physical processes you can deconstruct the climate and learn how all the different processes interact to generate the observed climate and how the processes interact to generate the IPCC predicted climate change for anthropogenic CO2 increase. The presentation will illustrate how this web-base tool works and what are the possibilities in teaching students with this tool are.

  11. Simple spherical ablative-implosion model

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, F.J.; Steele, J.T.; Larsen, J.T.

    1980-06-23

    A simple model of the ablative implosion of a high-aspect-ratio (shell radius to shell thickness ratio) spherical shell is described. The model is similar in spirit to Rosenbluth's snowplow model. The scaling of the implosion time was determined in terms of the ablation pressure and the shell parameters such as diameter, wall thickness, and shell density, and compared these to complete hydrodynamic code calculations. The energy transfer efficiency from ablation pressure to shell implosion kinetic energy was examined and found to be very efficient. It may be possible to attach a simple heat-transport calculation to our implosion model to describe the laser-driven ablation-implosion process. The model may be useful for determining other energy driven (e.g., ion beam) implosion scaling.

  12. Three Spreadsheet Models Of A Simple Pendulum

    Directory of Open Access Journals (Sweden)

    Jan Benacka

    2008-10-01

    Full Text Available The paper gives three spreadsheet models of simple pendulum motion. In two of them, the graph of the pendulum angle is drawn upon the exact integral solution using numeric integration – the simpler model only uses spreadsheet functions, the general model uses a VBA program. The period results directly from the calculations. In the third model, the period is calculated first using the power series formula. The graph of the pendulum angle is drawn afterwards using Euler’s method of solving differential equations. The error in gravity acceleration if calculated upon the standard cosine approximate formula instead of the exact one is graphed.

  13. The Two-Dimensional Gabor Function Adapted to Natural Image Statistics: A Model of Simple-Cell Receptive Fields and Sparse Structure in Images.

    Science.gov (United States)

    Loxley, P N

    2017-10-01

    The two-dimensional Gabor function is adapted to natural image statistics, leading to a tractable probabilistic generative model that can be used to model simple cell receptive field profiles, or generate basis functions for sparse coding applications. Learning is found to be most pronounced in three Gabor function parameters representing the size and spatial frequency of the two-dimensional Gabor function and characterized by a nonuniform probability distribution with heavy tails. All three parameters are found to be strongly correlated, resulting in a basis of multiscale Gabor functions with similar aspect ratios and size-dependent spatial frequencies. A key finding is that the distribution of receptive-field sizes is scale invariant over a wide range of values, so there is no characteristic receptive field size selected by natural image statistics. The Gabor function aspect ratio is found to be approximately conserved by the learning rules and is therefore not well determined by natural image statistics. This allows for three distinct solutions: a basis of Gabor functions with sharp orientation resolution at the expense of spatial-frequency resolution, a basis of Gabor functions with sharp spatial-frequency resolution at the expense of orientation resolution, or a basis with unit aspect ratio. Arbitrary mixtures of all three cases are also possible. Two parameters controlling the shape of the marginal distributions in a probabilistic generative model fully account for all three solutions. The best-performing probabilistic generative model for sparse coding applications is found to be a gaussian copula with Pareto marginal probability density functions.

  14. A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture.

    Science.gov (United States)

    Caccavale, Justin; Fiumara, David; Stapf, Michael; Sweitzer, Liedeke; Anderson, Hannah J; Gorky, Jonathan; Dhurjati, Prasad; Galileo, Deni S

    2017-12-11

    Glioblastoma multiforme (GBM) is a devastating brain cancer for which there is no known cure. Its malignancy is due to rapid cell division along with high motility and invasiveness of cells into the brain tissue. Simple 2-dimensional laboratory assays (e.g., a scratch assay) commonly are used to measure the effects of various experimental perturbations, such as treatment with chemical inhibitors. Several mathematical models have been developed to aid the understanding of the motile behavior and proliferation of GBM cells. However, many are mathematically complicated, look at multiple interdependent phenomena, and/or use modeling software not freely available to the research community. These attributes make the adoption of models and simulations of even simple 2-dimensional cell behavior an uncommon practice by cancer cell biologists. Herein, we developed an accurate, yet simple, rule-based modeling framework to describe the in vitro behavior of GBM cells that are stimulated by the L1CAM protein using freely available NetLogo software. In our model L1CAM is released by cells to act through two cell surface receptors and a point of signaling convergence to increase cell motility and proliferation. A simple graphical interface is provided so that changes can be made easily to several parameters controlling cell behavior, and behavior of the cells is viewed both pictorially and with dedicated graphs. We fully describe the hierarchical rule-based modeling framework, show simulation results under several settings, describe the accuracy compared to experimental data, and discuss the potential usefulness for predicting future experimental outcomes and for use as a teaching tool for cell biology students. It is concluded that this simple modeling framework and its simulations accurately reflect much of the GBM cell motility behavior observed experimentally in vitro in the laboratory. Our framework can be modified easily to suit the needs of investigators interested in other

  15. FSM Model of a Simple Photovoltaic System

    Directory of Open Access Journals (Sweden)

    Martina Latkova

    2015-01-01

    Full Text Available The paper describes a simulation model of a simple photovoltaic system intended as a tool for testing the use of finite state machines for simulations representing a long-term operation of renewable energy sources. The mathematical model of the photovoltaic system is described first. Then it is used to build a finite state machine model that calculates a power output of the photovoltaic system for changing values of a solar irradiance and a temperature. Data measured on a real photovoltaic installation are used to verify model’s accuracy through its comparison with a previously created and verified Matlab model. The finite state machine model presented in this paper was created using Ptolemy II software.

  16. Simple models of equilibrium and nonequilibrium phenomena

    International Nuclear Information System (INIS)

    Lebowitz, J.L.

    1987-01-01

    This volume consists of two chapters of particular interest to researchers in the field of statistical mechanics. The first chapter is based on the premise that the best way to understand the qualitative properties that characterize many-body (i.e. macroscopic) systems is to study 'a number of the more significant model systems which, at least in principle are susceptible of complete analysis'. The second chapter deals exclusively with nonequilibrium phenomena. It reviews the theory of fluctuations in open systems to which they have made important contributions. Simple but interesting model examples are emphasised

  17. A simple parametric model selection test

    OpenAIRE

    Susanne M. Schennach; Daniel Wilhelm

    2014-01-01

    We propose a simple model selection test for choosing among two parametric likelihoods which can be applied in the most general setting without any assumptions on the relation between the candidate models and the true distribution. That is, both, one or neither is allowed to be correctly speci fied or misspeci fied, they may be nested, non-nested, strictly non-nested or overlapping. Unlike in previous testing approaches, no pre-testing is needed, since in each case, the same test statistic to...

  18. Red blood cell in simple shear flow

    Science.gov (United States)

    Chien, Wei; Hew, Yayu; Chen, Yeng-Long

    2013-03-01

    The dynamics of red blood cells (RBC) in blood flow is critical for oxygen transport, and it also influences inflammation (white blood cells), thrombosis (platelets), and circulatory tumor migration. The physical properties of a RBC can be captured by modeling RBC as lipid membrane linked to a cytoskeletal spectrin network that encapsulates cytoplasm rich in hemoglobin, with bi-concave equilibrium shape. Depending on the shear force, RBC elasticity, membrane viscosity, and cytoplasm viscosity, RBC can undergo tumbling, tank-treading, or oscillatory motion. We investigate the dynamic state diagram of RBC in shear and pressure-driven flow using a combined immersed boundary-lattice Boltzmann method with a multi-scale RBC model that accurately captures the experimentally established RBC force-deformation relation. It is found that the tumbling (TU) to tank-treading (TT) transition occurs as shear rate increases for cytoplasm/outer fluid viscosity ratio smaller than 0.67. The TU frequency is found to be half of the TT frequency, in agreement with experiment observations. Larger viscosity ratios lead to the disappearance of stable TT phase and unstable complex dynamics, including the oscillation of the symmetry axis of the bi-concave shape perpendicular to the flow direction. The dependence on RBC bending rigidity, shear modulus, the order of membrane spectrin network and fluid field in the unstable region will also be discussed.

  19. Modeling reproductive decisions with simple heuristics

    Directory of Open Access Journals (Sweden)

    Peter Todd

    2013-10-01

    Full Text Available BACKGROUND Many of the reproductive decisions that humans make happen without much planning or forethought, arising instead through the use of simple choice rules or heuristics that involve relatively little information and processing. Nonetheless, these heuristic-guided decisions are typically beneficial, owing to humans' ecological rationality - the evolved fit between our constrained decision mechanisms and the adaptive problems we face. OBJECTIVE This paper reviews research on the ecological rationality of human decision making in the domain of reproduction, showing how fertility-related decisions are commonly made using various simple heuristics matched to the structure of the environment in which they are applied, rather than being made with information-hungry mechanisms based on optimization or rational economic choice. METHODS First, heuristics for sequential mate search are covered; these heuristics determine when to stop the process of mate search by deciding that a good-enough mate who is also mutually interested has been found, using a process of aspiration-level setting and assessing. These models are tested via computer simulation and comparison to demographic age-at-first-marriage data. Next, a heuristic process of feature-based mate comparison and choice is discussed, in which mate choices are determined by a simple process of feature-matching with relaxing standards over time. Parental investment heuristics used to divide resources among offspring are summarized. Finally, methods for testing the use of such mate choice heuristics in a specific population over time are then described.

  20. Chaos from simple models to complex systems

    CERN Document Server

    Cencini, Massimo; Vulpiani, Angelo

    2010-01-01

    Chaos: from simple models to complex systems aims to guide science and engineering students through chaos and nonlinear dynamics from classical examples to the most recent fields of research. The first part, intended for undergraduate and graduate students, is a gentle and self-contained introduction to the concepts and main tools for the characterization of deterministic chaotic systems, with emphasis to statistical approaches. The second part can be used as a reference by researchers as it focuses on more advanced topics including the characterization of chaos with tools of information theor

  1. A simple model of bank bankruptcies

    Science.gov (United States)

    Aleksiejuk, Agata; Hołyst, Janusz A.

    2001-10-01

    Interbank deposits (loans and credits) are quite common in banking system all over the world. Such interbank co-operation is profitable for banks but it can also lead to collective financial failures. In this paper, we introduce a new model of directed percolation as a simple representation for contagion process and mass bankruptcies in banking systems. Directed connections that are randomly distributed between junctions of bank lattice simulate flows of money in our model. Critical values of a mean density of interbank connections as well as static and dynamic scaling laws for the statistics of avalanche bankruptcies are found. Results of computer simulations for the universal profile of bankruptcies spreading are in a qualitative agreement with the third wave of bank suspensions during The Great Depression in USA.

  2. A simple model to understand the role of membrane shear elasticity and stress-free shape on the motion of red blood cells in shear flow

    Science.gov (United States)

    Viallat, Annie; Abkarian, Manouk; Dupire, Jules

    2015-11-01

    The analytical model presented by Keller and Skalak on the dynamics of red blood cells in shear flow described the cell as a fluid ellipsoid of fixed shape. It was extended to introduce shear elasticity of the cell membrane. We further extend the model when the cell discoid physiological shape is not a stress-free shape. We show that spheroid stress-free shapes enables fitting experimental data with values of shear elasticity typical to that found with micropipettes and optical tweezers. For moderate shear rates (when RBCs keep their discoid shape) this model enables to quantitatively determine an effective cell viscosity, that combines membrane and hemoglobin viscosities and an effective shear modulus of the membrane that combines shear modulus and stress-free shape. This model allows determining RBC mechanical parameters both in the tanktreading regime for cells suspended in a high viscosity medium, and in the tumbling regime for cells suspended in a low viscosity medium. In this regime,a transition is predicted between a rigid-like tumbling motion and a fluid-like tumbling motion above a critical shear rate, which is directly related to the mechanical parameters of the cell. A*MIDEX (n ANR-11-IDEX-0001-02) funded by the ''Investissements d'Avenir'', Region Languedoc-Roussillon, Labex NUMEV (ANR-10-LABX-20), BPI France project DataDiag.

  3. Trophic dynamics of a simple model ecosystem.

    Science.gov (United States)

    Bell, Graham; Fortier-Dubois, Étienne

    2017-09-13

    We have constructed a model of community dynamics that is simple enough to enumerate all possible food webs, yet complex enough to represent a wide range of ecological processes. We use the transition matrix to predict the outcome of succession and then investigate how the transition probabilities are governed by resource supply and immigration. Low-input regimes lead to simple communities whereas trophically complex communities develop when there is an adequate supply of both resources and immigrants. Our interpretation of trophic dynamics in complex communities hinges on a new principle of mutual replenishment, defined as the reciprocal alternation of state in a pair of communities linked by the invasion and extinction of a shared species. Such neutral couples are the outcome of succession under local dispersal and imply that food webs will often be made up of suites of trophically equivalent species. When immigrants arrive from an external pool of fixed composition a similar principle predicts a dynamic core of webs constituting a neutral interchange network, although communities may express an extensive range of other webs whose membership is only in part predictable. The food web is not in general predictable from whole-community properties such as productivity or stability, although it may profoundly influence these properties. © 2017 The Author(s).

  4. A simple mathematical model that describes the growth of the area and the number of total and viable cells in yeast colonies.

    Science.gov (United States)

    Rivas, E-M; Gil de Prado, E; Wrent, P; de Silóniz, M-I; Barreiro, P; Correa, E C; Conejero, F; Murciano, A; Peinado, J M

    2014-12-01

    We propose a model, based on the Gompertz equation, to describe the growth of yeasts colonies on agar medium. This model presents several advantages: (i) one equation describes the colony growth, which previously needed two separate ones (linear increase of radius and of the squared radius); (ii) a similar equation can be applied to total and viable cells, colony area or colony radius, because the number of total cells in mature colonies is proportional to their area; and (iii) its parameters estimate the cell yield, the cell concentration that triggers growth limitation and the effect of this limitation on the specific growth rate. To elaborate the model, area, total and viable cells of 600 colonies of Saccharomyces cerevisiae, Debaryomyces fabryi, Zygosaccharomyces rouxii and Rhodotorula glutinis have been measured. With low inocula, viable cells showed an initial short exponential phase when colonies were not visible. This phase was shortened with higher inocula. In visible or mature colonies, cell growth displayed Gompertz-type kinetics. It was concluded that the cells growth in colonies is similar to liquid cultures only during the first hours, the rest of the time they grow, with near-zero specific growth rates, at least for 3 weeks. Mathematical models used to predict microbial growth are based on liquid cultures data. Models describing growth on solid surfaces, highlighting the differences with liquids cultures, are scarce. In this work, we have demonstrated that a single Gompertz equation describes accurately the increase of the yeast colonies, up to the point where they reach their maximum size. The model can be used to quantify the differences in growth kinetics between solid and liquid media. Moreover, as all its parameters have biological meaning, it could be used to build secondary models predicting yeast growth on solid surfaces under several environmental conditions. © 2014 The Society for Applied Microbiology.

  5. Swarming behavior of simple model squirmers

    Energy Technology Data Exchange (ETDEWEB)

    Thutupalli, Shashi; Seemann, Ralf; Herminghaus, Stephan, E-mail: shashi.thutupalli@ds.mpg.de, E-mail: stephan.herminghaus@ds.mpg.de [Max Planck Institute for Dynamics and Self-Organization, Bunsenstrasse 10, 37073 Goettingen (Germany)

    2011-07-15

    We have studied experimentally the collective behavior of self-propelling liquid droplets, which closely mimic the locomotion of some protozoal organisms, the so-called squirmers. For the sake of simplicity, we concentrate on quasi-two-dimensional (2D) settings, although our swimmers provide a fully 3D propulsion scheme. At an areal density of 0.46, we find strong polar correlation of the locomotion velocities of neighboring droplets, which decays over less than one droplet diameter. When the areal density is increased to 0.78, distinct peaks show up in the angular correlation function, which point to the formation of ordered rafts. This shows that pronounced textures, beyond what has been seen in simulations so far, may show up in crowds of simple model squirmers, despite the simplicity of their (purely physical) mutual interaction.

  6. Rotational modes of a simple Earth model

    Science.gov (United States)

    Seyed-Mahmoud, B.; Rochester, M. G.; Rogister, Y. J. G.

    2017-12-01

    We study the tilt-over mode (TOM), the spin-over mode (SOM), the free core nutation (FCN), and their relationships to each other using a simple Earth model with a homogeneous and incompressible liquid core and a rigid mantle. Analytical solutions for the periods of these modes as well as that of the Chandler wobble is found for the Earth model. We show that the FCN is the same mode as the SOM of a wobbling Earth. The reduced pressure, in terms of which the vector momentum equation is known to reduce to a scalar second order differential equation (the so called Poincaŕe equation), is used as the independent variable. Analytical solutions are then found for the displacement eigenfucntions in a meridional plane of the liquid core for the aforementioned modes. We show that the magnitude of motion in the mantle during the FCN is comparable to that in the liquid core, hence very small. The displacement eigenfunctions for these aforementioned modes as well as those for the free inner core nutation (FICN), computed numerically, are also given for a three layer Earth model which also includes a rigid but capable of wobbling inner core. We will discuss the slow convergence of the period of the FICN in terms of the characteristic surfaces of the Poincare equation.

  7. Exact Fit of Simple Finite Mixture Models

    Directory of Open Access Journals (Sweden)

    Dirk Tasche

    2014-11-01

    Full Text Available How to forecast next year’s portfolio-wide credit default rate based on last year’s default observations and the current score distribution? A classical approach to this problem consists of fitting a mixture of the conditional score distributions observed last year to the current score distribution. This is a special (simple case of a finite mixture model where the mixture components are fixed and only the weights of the components are estimated. The optimum weights provide a forecast of next year’s portfolio-wide default rate. We point out that the maximum-likelihood (ML approach to fitting the mixture distribution not only gives an optimum but even an exact fit if we allow the mixture components to vary but keep their density ratio fixed. From this observation we can conclude that the standard default rate forecast based on last year’s conditional default rates will always be located between last year’s portfolio-wide default rate and the ML forecast for next year. As an application example, cost quantification is then discussed. We also discuss how the mixture model based estimation methods can be used to forecast total loss. This involves the reinterpretation of an individual classification problem as a collective quantification problem.

  8. Simple mathematical models of gene regulatory dynamics

    CERN Document Server

    Mackey, Michael C; Tyran-Kamińska, Marta; Zeron, Eduardo S

    2016-01-01

    This is a short and self-contained introduction to the field of mathematical modeling of gene-networks in bacteria. As an entry point to the field, we focus on the analysis of simple gene-network dynamics. The notes commence with an introduction to the deterministic modeling of gene-networks, with extensive reference to applicable results coming from dynamical systems theory. The second part of the notes treats extensively several approaches to the study of gene-network dynamics in the presence of noise—either arising from low numbers of molecules involved, or due to noise external to the regulatory process. The third and final part of the notes gives a detailed treatment of three well studied and concrete examples of gene-network dynamics by considering the lactose operon, the tryptophan operon, and the lysis-lysogeny switch. The notes contain an index for easy location of particular topics as well as an extensive bibliography of the current literature. The target audience of these notes are mainly graduat...

  9. A simple model for studying interacting networks

    Science.gov (United States)

    Liu, Wenjia; Jolad, Shivakumar; Schmittmann, Beate; Zia, R. K. P.

    2011-03-01

    Many specific physical networks (e.g., internet, power grid, interstates), have been characterized in considerable detail, but in isolation from each other. Yet, each of these networks supports the functions of the others, and so far, little is known about how their interactions affect their structure and functionality. To address this issue, we consider two coupled model networks. Each network is relatively simple, with a fixed set of nodes, but dynamically generated set of links which has a preferred degree, κ . In the stationary state, the degree distribution has exponential tails (far from κ), an attribute which we can explain. Next, we consider two such networks with different κ 's, reminiscent of two social groups, e.g., extroverts and introverts. Finally, we let these networks interact by establishing a controllable fraction of cross links. The resulting distribution of links, both within and across the two model networks, is investigated and discussed, along with some potential consequences for real networks. Supported in part by NSF-DMR-0705152 and 1005417.

  10. Simple Model for Detonation Energy and Rate

    Science.gov (United States)

    Lauderbach, Lisa M.; Souers, P. Clark

    2017-06-01

    A simple model is used to derive the Eyring equation for the size effect and detonation rate, which depends on a constant energy density. The rate derived from detonation velocities is then converted into a rate constant to be used in a reactive flow model. The rate might be constant if the size effect curve is straight, but the rate constant will change with the radius of the sample and cannot be a constant. This is based on many careful cylinder tests have been run recently on LX-17 with inner copper diameters ranging from 12.7 to 101.6 mm. Copper wall velocities at scaled displacements of 6, 12.5 and 19 mm equate to values at relative volumes of 2.4, 4.4 and 7.0. At each point, the velocities from 25.4 to 101.6 mm are constant within error whereas the 12.7 mm velocities are lower. Using the updated Gurney model, the energy densities at the three larger sizes are also constant. Similar behavior has been seen in LX-14, LX-04, and an 83% RDX mix. A rough saturation has also been in old ANFO data for diameters of 101.6 mm and larger. Although the energy densities saturate, the detonation velocities continue to increase with size. These observations suggest that maximum energy density is a constant for a given explosive of a given density. The correlation of energy density with detonation velocity is not good because the latter depends on the total energy of the sample. This work performed under the auspices of the U. S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  11. Simple micromechanical model of protein crystals for their mechanical characterizations

    Directory of Open Access Journals (Sweden)

    Na S.

    2010-06-01

    Full Text Available Proteins have been known to perform the excellent mechanical functions and exhibit the remarkable mechanical properties such as high fracture toughness in spider silk protein [1]. This indicates that the mechanical characterization of protein molecules and/or crystals is very essential to understand such remarkable mechanical function of protein molecules. In this study, for gaining insight into mechanical behavior of protein crystals, we developed the micromechanical model by using the empirical potential field prescribed to alpha carbon atoms of a protein crystal in a unit cell. We consider the simple protein crystals for their mechanical behavior under tensile loading to be compared with full atomic models

  12. Simple electrolytic cell for production of elemental fluorine

    International Nuclear Information System (INIS)

    Dides F, M.; Padilla S, U.

    1990-01-01

    It was constructed and tested a simple electrolytic cell for the production of elemental fluorine. The fluorine production is essential in the obtainment of uranium hexafluoride, a compound for the nuclear fuel cycle. (A.C.A.S.)

  13. Simple model of the slingshot effect

    Directory of Open Access Journals (Sweden)

    Gaetano Fiore

    2016-07-01

    Full Text Available We present a detailed quantitative description of the recently proposed “slingshot effect.” Namely, we determine a broad range of conditions under which the impact of a very short and intense laser pulse normally onto a low-density plasma (or matter locally completely ionized into a plasma by the pulse causes the expulsion of a bunch of surface electrons in the direction opposite to the one of propagation of the pulse, and the detailed, ready-for-experiments features of the expelled electrons (energy spectrum, collimation, etc. The effect is due to the combined actions of the ponderomotive force and the huge longitudinal field arising from charge separation. Our predictions are based on estimating 3D corrections to a simple, yet powerful plane 2-fluid magnetohydrodynamic (MHD model where the equations to be solved are reduced to a system of Hamilton equations in one dimension (or a collection of which become autonomous after the pulse has overcome the electrons. Experimental tests seem to be at hand. If confirmed by the latter, the effect would provide a new extraction and acceleration mechanism for electrons, alternative to traditional radio-frequency-based or Laser-Wake-Field ones.

  14. Simple models of the hydrofracture process

    KAUST Repository

    Marder, M.

    2015-12-29

    Hydrofracturing to recover natural gas and oil relies on the creation of a fracture network with pressurized water. We analyze the creation of the network in two ways. First, we assemble a collection of analytical estimates for pressure-driven crack motion in simple geometries, including crack speed as a function of length, energy dissipated by fluid viscosity and used to break rock, and the conditions under which a second crack will initiate while a first is running. We develop a pseudo-three-dimensional numerical model that couples fluid motion with solid mechanics and can generate branching crack structures not specified in advance. One of our main conclusions is that the typical spacing between fractures must be on the order of a meter, and this conclusion arises in two separate ways. First, it arises from analysis of gas production rates, given the diffusion constants for gas in the rock. Second, it arises from the number of fractures that should be generated given the scale of the affected region and the amounts of water pumped into the rock.

  15. Simple queueing approach to segregation dynamics in Schelling model

    OpenAIRE

    Sobkowicz, Pawel

    2007-01-01

    A simple queueing approach for segregation of agents in modified one dimensional Schelling segregation model is presented. The goal is to arrive at simple formula for the number of unhappy agents remaining after the segregation.

  16. Development and Validation of a Simple Analytical Model of the Proton Exchange Membrane Fuel Cell (Pemfc) in a Fork-Lift Truck Power System

    DEFF Research Database (Denmark)

    Hosseinzadeh, Elham; Rokni, Masoud

    2013-01-01

    In this study, a general proton exchange membrane fuel cell (PEMFC) model has been developed in order to investigate the balance of plant of a fork-lift truck thermodynamically. The model takes into account the effects of pressure losses, water crossovers, humidity aspects, and voltage...... management, system sensitivity to coolant inlet temperature, air and fuel stoichiometry, anode inlet pressure, stack operating conditions, etc. System efficiency and electrical power at different operating conditions are also discussed. The results show that 12–30% of stack power is allocated...

  17. Simple Model for Identifying Critical Regions in Atrial Fibrillation

    Science.gov (United States)

    Christensen, Kim; Manani, Kishan A.; Peters, Nicholas S.

    2015-01-01

    Atrial fibrillation (AF) is the most common abnormal heart rhythm and the single biggest cause of stroke. Ablation, destroying regions of the atria, is applied largely empirically and can be curative but with a disappointing clinical success rate. We design a simple model of activation wave front propagation on an anisotropic structure mimicking the branching network of heart muscle cells. This integration of phenomenological dynamics and pertinent structure shows how AF emerges spontaneously when the transverse cell-to-cell coupling decreases, as occurs with age, beyond a threshold value. We identify critical regions responsible for the initiation and maintenance of AF, the ablation of which terminates AF. The simplicity of the model allows us to calculate analytically the risk of arrhythmia and express the threshold value of transversal cell-to-cell coupling as a function of the model parameters. This threshold value decreases with increasing refractory period by reducing the number of critical regions which can initiate and sustain microreentrant circuits. These biologically testable predictions might inform ablation therapies and arrhythmic risk assessment.

  18. Simple Models for the Dynamic Modeling of Rotating Tires

    Directory of Open Access Journals (Sweden)

    J.C. Delamotte

    2008-01-01

    Full Text Available Large Finite Element (FE models of tires are currently used to predict low frequency behavior and to obtain dynamic model coefficients used in multi-body models for riding and comfort. However, to predict higher frequency behavior, which may explain irregular wear, critical rotating speeds and noise radiation, FE models are not practical. Detailed FE models are not adequate for optimization and uncertainty predictions either, as in such applications the dynamic solution must be computed a number of times. Therefore, there is a need for simpler models that can capture the physics of the tire and be used to compute the dynamic response with a low computational cost. In this paper, the spectral (or continuous element approach is used to derive such a model. A circular beam spectral element that takes into account the string effect is derived, and a method to simulate the response to a rotating force is implemented in the frequency domain. The behavior of a circular ring under different internal pressures is investigated using modal and frequency/wavenumber representations. Experimental results obtained with a real untreaded truck tire are presented and qualitatively compared with the simple model predictions with good agreement. No attempt is made to obtain equivalent parameters for the simple model from the real tire results. On the other hand, the simple model fails to represent the correct variation of the quotient of the natural frequency by the number of circumferential wavelengths with the mode count. Nevertheless, some important features of the real tire dynamic behavior, such as the generation of standing waves and part of the frequency/wavenumber behavior, can be investigated using the proposed simplified model.

  19. Modelling of the simple pendulum Experiment

    Directory of Open Access Journals (Sweden)

    Palka L.

    2016-01-01

    Full Text Available Abstract - work focuses on the design of the simulation embedded in remote experiment “Simple pendulum” built on the Internet School Experimental System (ISES. This platform is intended for wide educational purposes at schools and universities in order to provide the suitable measuring environment for students using conventional computing resources Informatics.

  20. tBid and cardiolipin - trying an insight to the interplay of cell apoptosis key players in a simple model system

    DEFF Research Database (Denmark)

    Perry, Mark; Rostovtseva, Tanya; Antonsson, Bruno

    he abundant presence of cardiolipin (CL) in mitochondria membranes has given rise to the suspicion that this lipid play be an essential role in triggering cell apoptosis, possibly by mechanically destabilizing the host membrane and thus enhancing the effect of the tBid apoptosis protein. Therefore...... the mechanical effect of the presence of CL in model bilayer membranes was investigated by a combination of micromechanical deformation studies and differential calorimetry (DSC). The calorimetry data are not easy to interpret due to the continuous chemical decay of the system upon hydrolysis. The induction...... of hexagonal phases was not observed in the low contents regime (CLdiagram could be constructed (CL

  1. Diffraction enhanced imaging: a simple model

    International Nuclear Information System (INIS)

    Zhu Peiping; Yuan Qingxi; Huang Wanxia; Wang Junyue; Shu Hang; Chen Bo; Liu Yijin; Li Enrong; Wu Ziyu

    2006-01-01

    Based on pinhole imaging and conventional x-ray projection imaging, a more general DEI (diffraction enhanced imaging) equation is derived using simple concepts in this paper. Not only can the new DEI equation explain all the same problems as with the DEI equation proposed by Chapman, but also some problems that cannot be explained with the old DEI equation, such as the noise background caused by small angle scattering diffracted by the analyser

  2. Diffraction enhanced imaging: a simple model

    Energy Technology Data Exchange (ETDEWEB)

    Zhu Peiping; Yuan Qingxi; Huang Wanxia; Wang Junyue; Shu Hang; Chen Bo; Liu Yijin; Li Enrong; Wu Ziyu [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2006-10-07

    Based on pinhole imaging and conventional x-ray projection imaging, a more general DEI (diffraction enhanced imaging) equation is derived using simple concepts in this paper. Not only can the new DEI equation explain all the same problems as with the DEI equation proposed by Chapman, but also some problems that cannot be explained with the old DEI equation, such as the noise background caused by small angle scattering diffracted by the analyser.

  3. LBA-ECO LC-31 Simple Tropical Ecosystem Model

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: This model product provides the Fortran source code and input data for the Simple Tropical Ecosystem Model (SITE). SITE is a simplified point model of...

  4. LBA-ECO LC-31 Simple Tropical Ecosystem Model

    Data.gov (United States)

    National Aeronautics and Space Administration — This model product provides the Fortran source code and input data for the Simple Tropical Ecosystem Model (SITE). SITE is a simplified point model of vegetation...

  5. Simple membrane-based model of the Min oscillator

    Science.gov (United States)

    Petrášek, Zdeněk; Schwille, Petra

    2015-04-01

    Min proteins in E. coli bacteria organize into a dynamic pattern oscillating between the two cell poles. This process identifies the middle of the cell and enables symmetric cell division. In an experimental model system consisting of a flat membrane with effectively infinite supply of proteins and energy source, the Min proteins assemble into travelling waves. Here we propose a simple one-dimensional model of the Min dynamics that, unlike the existing models, reproduces the sharp decrease of Min concentration when the majority of protein detaches from the membrane, and even the narrow MinE maximum immediately preceding the detachment. The proposed model thus provides a possible mechanism for the formation of the MinE ring known from cells. The model is restricted to one dimension, with protein interactions described by chemical kinetics allowing at most bimolecular reactions, and explicitly considering only three, membrane-bound, species. The bulk solution above the membrane is approximated as being well-mixed, with constant concentrations of all species. Unlike other models, our proposal does not require autocatalytic binding of MinD to the membrane. Instead, it is assumed that two MinE molecules are necessary to induce the dissociation of the MinD dimer and its subsequent detachment from the membrane. We investigate which reaction schemes lead to unstable homogeneous steady states and limit cycle oscillations, and how diffusion affects their stability. The suggested model qualitatively describes the shape of the Min waves observed on flat membranes, and agrees with the experimental dependence of the wave period on the MinE concentration. These results highlight the importance of MinE presence on the membrane without being bound to MinD, and of the reactions of Min proteins on the membrane.

  6. Simple membrane-based model of the Min oscillator

    International Nuclear Information System (INIS)

    Petrášek, Zdeněk; Schwille, Petra

    2015-01-01

    Min proteins in E. coli bacteria organize into a dynamic pattern oscillating between the two cell poles. This process identifies the middle of the cell and enables symmetric cell division. In an experimental model system consisting of a flat membrane with effectively infinite supply of proteins and energy source, the Min proteins assemble into travelling waves. Here we propose a simple one-dimensional model of the Min dynamics that, unlike the existing models, reproduces the sharp decrease of Min concentration when the majority of protein detaches from the membrane, and even the narrow MinE maximum immediately preceding the detachment. The proposed model thus provides a possible mechanism for the formation of the MinE ring known from cells. The model is restricted to one dimension, with protein interactions described by chemical kinetics allowing at most bimolecular reactions, and explicitly considering only three, membrane-bound, species. The bulk solution above the membrane is approximated as being well-mixed, with constant concentrations of all species. Unlike other models, our proposal does not require autocatalytic binding of MinD to the membrane. Instead, it is assumed that two MinE molecules are necessary to induce the dissociation of the MinD dimer and its subsequent detachment from the membrane. We investigate which reaction schemes lead to unstable homogeneous steady states and limit cycle oscillations, and how diffusion affects their stability. The suggested model qualitatively describes the shape of the Min waves observed on flat membranes, and agrees with the experimental dependence of the wave period on the MinE concentration. These results highlight the importance of MinE presence on the membrane without being bound to MinD, and of the reactions of Min proteins on the membrane. (paper)

  7. A simple non-linear model of immune response

    International Nuclear Information System (INIS)

    Gutnikov, Sergei; Melnikov, Yuri

    2003-01-01

    It is still unknown why the adaptive immune response in the natural immune system based on clonal proliferation of lymphocytes requires interaction of at least two different cell types with the same antigen. We present a simple mathematical model illustrating that the system with separate types of cells for antigen recognition and patogen destruction provides more robust adaptive immunity than the system where just one cell type is responsible for both recognition and destruction. The model is over-simplified as we did not have an intention of describing the natural immune system. However, our model provides a tool for testing the proposed approach through qualitative analysis of the immune system dynamics in order to construct more sophisticated models of the immune systems that exist in the living nature. It also opens a possibility to explore specific features of highly non-linear dynamics in nature-inspired computational paradigms like artificial immune systems and immunocomputing . We expect this paper to be of interest not only for mathematicians but also for biologists; therefore we made effort to explain mathematics in sufficient detail for readers without professional mathematical background

  8. A simple probabilistic model of ideal gases

    Science.gov (United States)

    Sossinsky, A. B.

    2016-01-01

    We describe a discrete 3D model of ideal gas based on the idea that, on the microscopic level, the particles move randomly (as in ASEP models), instead of obeying Newton's laws as prescribed by Boltzmann.

  9. Response of Simple, Model Systems to Extreme Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Ewing, Rodney C. [Univ. of Michigan, Ann Arbor, MI (United States); Lang, Maik [Univ. of Michigan, Ann Arbor, MI (United States)

    2015-07-30

    The focus of the research was on the application of high-pressure/high-temperature techniques, together with intense energetic ion beams, to the study of the behavior of simple oxide systems (e.g., SiO2, GeO2, CeO2, TiO2, HfO2, SnO2, ZnO and ZrO2) under extreme conditions. These simple stoichiometries provide unique model systems for the analysis of structural responses to pressure up to and above 1 Mbar, temperatures of up to several thousands of kelvin, and the extreme energy density generated by energetic heavy ions (tens of keV/atom). The investigations included systematic studies of radiation- and pressure-induced amorphization of high P-T polymorphs. By studying the response of simple stoichiometries that have multiple structural “outcomes”, we have established the basic knowledge required for the prediction of the response of more complex structures to extreme conditions. We especially focused on the amorphous state and characterized the different non-crystalline structure-types that result from the interplay of radiation and pressure. For such experiments, we made use of recent technological developments, such as the perforated diamond-anvil cell and in situ investigation using synchrotron x-ray sources. We have been particularly interested in using extreme pressures to alter the electronic structure of a solid prior to irradiation. We expected that the effects of modified band structure would be evident in the track structure and morphology, information which is much needed to describe theoretically the fundamental physics of track-formation. Finally, we investigated the behavior of different simple-oxide, composite nanomaterials (e.g., uncoated nanoparticles vs. core/shell systems) under coupled, extreme conditions. This provided insight into surface and boundary effects on phase stability under extreme conditions.

  10. Applications: simple models and difficult theorems

    NARCIS (Netherlands)

    Litvak, Nelli; van de Geer, Sara; Wegkamp, Marten

    2012-01-01

    In this short article I will discuss three papers written by Willem van Zwet with three different co-authors: Mathisca de Gunst, Marta Fiocco, and myself. Each of the papers focuses on one particular application: growth of the number of biological cells [3], spreading of an infection [7], and the

  11. The Structured Intuitive Model for Product Line Economics (SIMPLE)

    National Research Council Canada - National Science Library

    Clements, Paul C; McGregor, John D; Cohen, Sholom G

    2005-01-01

    .... This report presents the Structured Intuitive Model of Product Line Economics (SIMPLE), a general-purpose business model that supports the estimation of the costs and benefits in a product line development organization...

  12. Simple opdriftsbaserede modeller for Wave Star

    DEFF Research Database (Denmark)

    Kramer, Morten

    Wave Star modellen er udarbejdet i programmeringssproget Delphi. Modellerne er en videre udarbejdelse af tidligere anvendte Excel-modeller. I forhold til Excelmodellerne udmærker de nye Dephi-modeller sig ved at beregningerne udføres mange gange hurtigere og modellerne kan håndtere lange tidsserier...

  13. Flocking regimes in a simple lattice model.

    Science.gov (United States)

    Raymond, J R; Evans, M R

    2006-03-01

    We study a one-dimensional lattice flocking model incorporating all three of the flocking criteria proposed by Reynolds [Computer Graphics 21, 4 (1987)]: alignment, centering, and separation. The model generalizes that introduced by O. J. O'Loan and M. R. Evans [J. Phys. A. 32, L99 (1999)]. We motivate the dynamical rules by microscopic sampling considerations. The model exhibits various flocking regimes: the alternating flock, the homogeneous flock, and dipole structures. We investigate these regimes numerically and within a continuum mean-field theory.

  14. Simple statistical model for branched aggregates

    DEFF Research Database (Denmark)

    Lemarchand, Claire; Hansen, Jesper Schmidt

    2015-01-01

    We propose a statistical model that can reproduce the size distribution of any branched aggregate, including amylopectin, dendrimers, molecular clusters of monoalcohols, and asphaltene nanoaggregates. It is based on the conditional probability for one molecule to form a new bond with a molecule......, given that it already has bonds with others. The model is applied here to asphaltene nanoaggregates observed in molecular dynamics simulations of Cooee bitumen. The variation with temperature of the probabilities deduced from this model is discussed in terms of statistical mechanics arguments....... The relevance of the statistical model in the case of asphaltene nanoaggregates is checked by comparing the predicted value of the probability for one molecule to have exactly i bonds with the same probability directly measured in the molecular dynamics simulations. The agreement is satisfactory...

  15. Are v1 simple cells optimized for visual occlusions? A comparative study.

    Directory of Open Access Journals (Sweden)

    Jörg Bornschein

    Full Text Available Simple cells in primary visual cortex were famously found to respond to low-level image components such as edges. Sparse coding and independent component analysis (ICA emerged as the standard computational models for simple cell coding because they linked their receptive fields to the statistics of visual stimuli. However, a salient feature of image statistics, occlusions of image components, is not considered by these models. Here we ask if occlusions have an effect on the predicted shapes of simple cell receptive fields. We use a comparative approach to answer this question and investigate two models for simple cells: a standard linear model and an occlusive model. For both models we simultaneously estimate optimal receptive fields, sparsity and stimulus noise. The two models are identical except for their component superposition assumption. We find the image encoding and receptive fields predicted by the models to differ significantly. While both models predict many Gabor-like fields, the occlusive model predicts a much sparser encoding and high percentages of 'globular' receptive fields. This relatively new center-surround type of simple cell response is observed since reverse correlation is used in experimental studies. While high percentages of 'globular' fields can be obtained using specific choices of sparsity and overcompleteness in linear sparse coding, no or only low proportions are reported in the vast majority of studies on linear models (including all ICA models. Likewise, for the here investigated linear model and optimal sparsity, only low proportions of 'globular' fields are observed. In comparison, the occlusive model robustly infers high proportions and can match the experimentally observed high proportions of 'globular' fields well. Our computational study, therefore, suggests that 'globular' fields may be evidence for an optimal encoding of visual occlusions in primary visual cortex.

  16. Are v1 simple cells optimized for visual occlusions? A comparative study.

    Science.gov (United States)

    Bornschein, Jörg; Henniges, Marc; Lücke, Jörg

    2013-01-01

    Simple cells in primary visual cortex were famously found to respond to low-level image components such as edges. Sparse coding and independent component analysis (ICA) emerged as the standard computational models for simple cell coding because they linked their receptive fields to the statistics of visual stimuli. However, a salient feature of image statistics, occlusions of image components, is not considered by these models. Here we ask if occlusions have an effect on the predicted shapes of simple cell receptive fields. We use a comparative approach to answer this question and investigate two models for simple cells: a standard linear model and an occlusive model. For both models we simultaneously estimate optimal receptive fields, sparsity and stimulus noise. The two models are identical except for their component superposition assumption. We find the image encoding and receptive fields predicted by the models to differ significantly. While both models predict many Gabor-like fields, the occlusive model predicts a much sparser encoding and high percentages of 'globular' receptive fields. This relatively new center-surround type of simple cell response is observed since reverse correlation is used in experimental studies. While high percentages of 'globular' fields can be obtained using specific choices of sparsity and overcompleteness in linear sparse coding, no or only low proportions are reported in the vast majority of studies on linear models (including all ICA models). Likewise, for the here investigated linear model and optimal sparsity, only low proportions of 'globular' fields are observed. In comparison, the occlusive model robustly infers high proportions and can match the experimentally observed high proportions of 'globular' fields well. Our computational study, therefore, suggests that 'globular' fields may be evidence for an optimal encoding of visual occlusions in primary visual cortex.

  17. Statistical tests of simple earthquake cycle models

    Science.gov (United States)

    Devries, Phoebe M. R.; Evans, Eileen

    2016-01-01

    A central goal of observing and modeling the earthquake cycle is to forecast when a particular fault may generate an earthquake: a fault late in its earthquake cycle may be more likely to generate an earthquake than a fault early in its earthquake cycle. Models that can explain geodetic observations throughout the entire earthquake cycle may be required to gain a more complete understanding of relevant physics and phenomenology. Previous efforts to develop unified earthquake models for strike-slip faults have largely focused on explaining both preseismic and postseismic geodetic observations available across a few faults in California, Turkey, and Tibet. An alternative approach leverages the global distribution of geodetic and geologic slip rate estimates on strike-slip faults worldwide. Here we use the Kolmogorov-Smirnov test for similarity of distributions to infer, in a statistically rigorous manner, viscoelastic earthquake cycle models that are inconsistent with 15 sets of observations across major strike-slip faults. We reject a large subset of two-layer models incorporating Burgers rheologies at a significance level of α = 0.05 (those with long-term Maxwell viscosities ηM ~ 4.6 × 1020 Pa s) but cannot reject models on the basis of transient Kelvin viscosity ηK. Finally, we examine the implications of these results for the predicted earthquake cycle timing of the 15 faults considered and compare these predictions to the geologic and historical record.

  18. Spatial and Temporal Clustering in a Simple Earthquake Asperity Model

    Science.gov (United States)

    Tiampo, K. F.; Kazemian, J.; Dominguez, R.; Klein, W.

    2016-12-01

    Natural earthquake fault systems are highly heterogeneous in space, the result of inhomogeneities that are a function of the variety of materials of different strengths. However, despite their inhomogeneous nature, real faults are often modeled as spatially homogeneous systems. Here we present a simple earthquake fault model based on the Olami-Feder-Christensen (OFC) and Rundle-Jackson-Brown (RJB) cellular automata models with long-range interactions that incorporates asperities, or stronger sites, into the lattice (Rundle and Jackson, 1977; Olami et al., 1992). These asperity cells are significantly stronger than the surrounding lattice sites but eventually rupture when the applied stress reaches their higher threshold stress. The introduction of these spatial heterogeneities results in spatial and temporal clustering in the model similar to that seen in natural fault systems. We observe sequences of activity that begin with a gradually accelerating number of larger events, or foreshocks, prior to a large event, followed by a tail of decreasing activity, or aftershocks. These recurrent large events occur at regular intervals and the characteristic time between events and their magnitude are a function of the stress dissipation parameter. The relative length of the foreshock to aftershock sequence depends on the amount of stress dissipation in the system. This work provides further evidence that the spatial and temporal patterns observed in natural seismicity are strongly influenced by the underlying physical properties and are not solely the result of a simple cascade mechanism. We find that the scaling depends not only on the amount of damage, but also on the spatial distribution of that damage (Dominguez et al., 2011; Kazemian et al., 2014). Here we compare the modeled sequences to those of natural earthquake sequences from California and around the world in order to investigate the interplay between cascade dynamics and spatial structure.

  19. A Study of Simple Diffraction Models

    DEFF Research Database (Denmark)

    Agerkvist, Finn

    1997-01-01

    Three different models for calculating edge diffraction are examined. The methods of Vanderkooy, Terai and Biot & Tolstoy are compared with measurements. Although a good agreement is obtained, the measurements also show that none of the methods work completely satisfactorily. The desired properties...

  20. Urban drainage models - making uncertainty analysis simple

    DEFF Research Database (Denmark)

    Vezzaro, Luca; Mikkelsen, Peter Steen; Deletic, Ana

    2012-01-01

    There is increasing awareness about uncertainties in modelling of urban drainage systems and, as such, many new methods for uncertainty analyses have been developed. Despite this, all available methods have limitations which restrict their widespread application among practitioners. Here, a modif...

  1. A Simple Macro-Economic Model

    Science.gov (United States)

    Carr, J. L.

    1976-01-01

    A simplified model based on assumed linear realtionships between the main variables is used to show how changes in expenditure, tax rate, etc. affect other parts of the national economy in successive periods. See SO 505 143 for ordering information. (Author/ND)

  2. A simple model of bedform migration

    DEFF Research Database (Denmark)

    Bartholdy, Jesper; Ernstsen, Verner Brandbyge; Flemming, Burg W

    2010-01-01

    A model linking subaqueous dune migration to the effective (grain related) shear stress is calibrated by means of flume data for bedform dimensions and migration rates. The effective shear stress is calculated on the basis of a new method assuming a near-bed layer above the mean bed level in which...... the current velocity accelerates towards the bedform crest. As a consequence, the effective bed shear stress corresponds to the shear stress acting directly on top of the bedform. The model operates with the critical Shields stress as a function of grain size, and predicts the deposition (volume per unit time...... values of qb(crest) correlate with measured values of bedform height multiplied by bedform migration rate with R-2 = 0.83. Copyright (C) 2010 John Wiley & Sons, Ltd...

  3. Superficial tension: experimental model with simple materials

    Directory of Open Access Journals (Sweden)

    Tintori Ferreira, María Alejandra

    2012-09-01

    Full Text Available In this work appears a didactic offer based on an experimental activity using materials of very low cost, orientated to achieving that the student understand and interpret the phenomenon of superficial tension together with the importance of the modeling in sciences. It has as principal aim of education bring the student over to the mechanics of the static fluids and the intermolecular forces, combining scientific contents with questions near to the student what provides an additional motivation to the reflection of the scientific investigation.

  4. Simple Analytic Models of Gravitational Collapse

    Energy Technology Data Exchange (ETDEWEB)

    Adler, R.

    2005-02-09

    Most general relativity textbooks devote considerable space to the simplest example of a black hole containing a singularity, the Schwarzschild geometry. However only a few discuss the dynamical process of gravitational collapse, by which black holes and singularities form. We present here two types of analytic models for this process, which we believe are the simplest available; the first involves collapsing spherical shells of light, analyzed mainly in Eddington-Finkelstein coordinates; the second involves collapsing spheres filled with a perfect fluid, analyzed mainly in Painleve-Gullstrand coordinates. Our main goal is pedagogical simplicity and algebraic completeness, but we also present some results that we believe are new, such as the collapse of a light shell in Kruskal-Szekeres coordinates.

  5. A Simple General Model of Evolutionary Dynamics

    Science.gov (United States)

    Thurner, Stefan

    Evolution is a process in which some variations that emerge within a population (of, e.g., biological species or industrial goods) get selected, survive, and proliferate, whereas others vanish. Survival probability, proliferation, or production rates are associated with the "fitness" of a particular variation. We argue that the notion of fitness is an a posteriori concept in the sense that one can assign higher fitness to species or goods that survive but one can generally not derive or predict fitness per se. Whereas proliferation rates can be measured, fitness landscapes, that is, the inter-dependence of proliferation rates, cannot. For this reason we think that in a physical theory of evolution such notions should be avoided. Here we review a recent quantitative formulation of evolutionary dynamics that provides a framework for the co-evolution of species and their fitness landscapes (Thurner et al., 2010, Physica A 389, 747; Thurner et al., 2010, New J. Phys. 12, 075029; Klimek et al., 2009, Phys. Rev. E 82, 011901 (2010). The corresponding model leads to a generic evolutionary dynamics characterized by phases of relative stability in terms of diversity, followed by phases of massive restructuring. These dynamical modes can be interpreted as punctuated equilibria in biology, or Schumpeterian business cycles (Schumpeter, 1939, Business Cycles, McGraw-Hill, London) in economics. We show that phase transitions that separate phases of high and low diversity can be approximated surprisingly well by mean-field methods. We demonstrate that the mathematical framework is suited to understand systemic properties of evolutionary systems, such as their proneness to collapse, or their potential for diversification. The framework suggests that evolutionary processes are naturally linked to self-organized criticality and to properties of production matrices, such as their eigenvalue spectra. Even though the model is phrased in general terms it is also practical in the sense

  6. Modeling Exposure to Heat Stress with a Simple Urban Model

    Directory of Open Access Journals (Sweden)

    Peter Hoffmann

    2018-01-01

    Full Text Available As a first step in modeling health-related urban well-being (UrbWellth, a mathematical model is constructed that dynamically simulates heat stress exposure of commuters in an idealized city. This is done by coupling the Simple Urban Radiation Model (SURM, which computes the mean radiant temperature ( T m r t , with a newly developed multi-class multi-mode traffic model. Simulation results with parameters chosen for the city of Hamburg for a hot summer day show that commuters are potentially most exposed to heat stress in the early afternoon when T m r t has its maximum. Varying the morphology with respect to street width and building height shows that a more compact city configuration reduces T m r t and therefore the exposure to heat stress. The impact resulting from changes in the city structure on traffic is simulated to determine the time spent outside during the commute. While the time in traffic jams increases for compact cities, the total commuting time decreases due to shorter distances between home and work place. Concerning adaptation measures, it is shown that increases in the albedo of the urban surfaces lead to an increase in daytime heat stress. Dramatic increases in heat stress exposure are found when both, wall and street albedo, are increased.

  7. An accurate and simple large signal model of HEMT

    DEFF Research Database (Denmark)

    Liu, Qing

    1989-01-01

    A large-signal model of discrete HEMTs (high-electron-mobility transistors) has been developed. It is simple and suitable for SPICE simulation of hybrid digital ICs. The model parameters are extracted by using computer programs and data provided by the manufacturer. Based on this model, a hybrid...

  8. Validation of updated neutronic calculation models proposed for Atucha-II PHWR. Part II: Benchmark comparisons of PUMA core parameters with MCNP5 and improvements due to a simple cell heterogeneity correction

    International Nuclear Information System (INIS)

    Grant, C.; Mollerach, R.; Leszczynski, F.; Serra, O.; Marconi, J.; Fink, J.

    2006-01-01

    In 2005 the Argentine Government took the decision to complete the construction of the Atucha-II nuclear power plant, which has been progressing slowly during the last ten years. Atucha-II is a 745 MWe nuclear station moderated and cooled with heavy water, of German (Siemens) design located in Argentina. It has a pressure vessel design with 451 vertical coolant channels and the fuel assemblies (FA) are clusters of 37 natural UO 2 rods with an active length of 530 cm. For the reactor physics area, a revision and update of reactor physics calculation methods and models was recently carried out covering cell, supercell (control rod) and core calculations. This paper presents benchmark comparisons of core parameters of a slightly idealized model of the Atucha-I core obtained with the PUMA reactor code with MCNP5. The Atucha-I core was selected because it is smaller, similar from a neutronic point of view, more symmetric than Atucha-II, and has some experimental data available. To validate the new models benchmark comparisons of k-effective, channel power and axial power distributions obtained with PUMA and MCNP5 have been performed. In addition, a simple cell heterogeneity correction recently introduced in PUMA is presented, which improves significantly the agreement of calculated channel powers with MCNP5. To complete the validation, the calculation of some of the critical configurations of the Atucha-I reactor measured during the experiments performed at first criticality is also presented. (authors)

  9. tBid and cardiolipin - trying an insight to the interplay of cell apoptosis key players in a simple model system

    DEFF Research Database (Denmark)

    Perry, Mark; Rostovtseva, Tanya; Antonsson, Bruno

    he abundant presence of cardiolipin (CL) in mitochondria membranes has given rise to the suspicion that this lipid play be an essential role in triggering cell apoptosis, possibly by mechanically destabilizing the host membrane and thus enhancing the effect of the tBid apoptosis protein. Therefore...... and absence of CL. We interpret this as a formation of patches of protein-lipid clusters that in effect reduce the amount of expandable fluid membrane area. The rupture tension falls significantly as soon as tBid is present on the outer vesicle membrane....

  10. A simple method for stem cell labeling with fluorine 18

    International Nuclear Information System (INIS)

    Ma Bing; Hankenson, Kurt D.; Dennis, James E.; Caplan, Arnold I.; Goldstein, Steven A.; Kilbourn, Michael R.

    2005-01-01

    Hexadecyl-4-[ 18 F]fluorobenzoate ([ 18 F]HFB), a long chain fluorinated benzoic acid ester, was prepared in a one-step synthesis by aromatic nucleophilic substitution of [ 18 F]fluoride ion on hexadecyl-4-(N,N,N-trimethylammonio)benzoate. The radiolabeled ester was obtained in good yields (52% decay corrected) and high purity (97%). [ 18 F]HFB was used to radiolabel rat mesenchymal stem cells (MSCs) by absorption into cell membranes. MicroPET imaging of [ 18 F]HFB-labeled MSCs following intravenous injection into the rat showed the expected high and persistent accumulation of radioactivity in the lungs. [ 18 F]HFB is thus simple to prepare and uses labeling agent for short-term distribution studies of injected stem cells

  11. Application of Simple CFD Models in Smoke Ventilation Design

    DEFF Research Database (Denmark)

    Brohus, Henrik; Nielsen, Peter Vilhelm; la Cour-Harbo, Hans

    2004-01-01

    The paper examines the possibilities of using simple CFD models in practical smoke ventilation design. The aim is to assess if it is possible with a reasonable accuracy to predict the behaviour of smoke transport in case of a fire. A CFD code mainly applicable for “ordinary” ventilation design...... uses a standard k-ε turbulence model. Simulations comprise both steady-state and dynamic approaches. Several boundary conditions are tested. Finally, the paper discusses the prospects of simple CFD models in smoke ventilation design including the inherent limitations....

  12. A simple model of a Slinky walking down stairs

    Science.gov (United States)

    Hu, Ai-Ping

    2010-01-01

    The motion of a Slinky walking down a set of stairs is modeled by a simple dynamical system with two degrees of freedom undergoing inelastic collisions. Numerical integration of the model's equations of motion shows that the model's behavior is similar to observations of the motion of an actual Slinky. In particular, it is found that the model's motion exhibits a periodic gait, although subject to more restrictive launch conditions than an actual Slinky.

  13. A simple mechanical model for the isotropic harmonic oscillator

    International Nuclear Information System (INIS)

    Nita, Gelu M

    2010-01-01

    A constrained elastic pendulum is proposed as a simple mechanical model for the isotropic harmonic oscillator. The conceptual and mathematical simplicity of this model recommends it as an effective pedagogical tool in teaching basic physics concepts at advanced high school and introductory undergraduate course levels.

  14. Simple mathematical models for housing allocation to a homeless ...

    African Journals Online (AJOL)

    We present simple mathematical models for modelling a homeless population and housing allocation. We look at a situation whereby the local authority makes temporary accommodation available for some of the homeless for a while and we examine how this affects the number of families homeless at any given time.

  15. Some simple applications of probability models to birth intervals

    International Nuclear Information System (INIS)

    Shrestha, G.

    1987-07-01

    An attempt has been made in this paper to apply some simple probability models to birth intervals under the assumption of constant fecundability and varying fecundability among women. The parameters of the probability models are estimated by using the method of moments and the method of maximum likelihood. (author). 9 refs, 2 tabs

  16. Timed Automaton Models for Simple Programmable Logic Controllers

    NARCIS (Netherlands)

    Mader, Angelika H.; Wupper, Hanno

    We give timed automaton models for a class of Programmable Logic Controller (PLC) applications, that are programmed in a simple fragment of the language Instruction Lists as defined in the standard IEC 1131-3. Two different approaches for modelling timers are suggested, that lead to two different

  17. Design and Use of the Simple Event Model (SEM)

    NARCIS (Netherlands)

    van Hage, W.R.; Malaisé, V.; Segers, R.H.; Hollink, L.

    2011-01-01

    Events have become central elements in the representation of data from domains such as history, cultural heritage, multimedia and geography. The Simple Event Model (SEM) is created to model events in these various domains, without making assumptions about the domain-specific vocabularies used. SEM

  18. Y-Scaling in a simple quark model

    International Nuclear Information System (INIS)

    Kumano, S.; Moniz, E.J.

    1988-01-01

    A simple quark model is used to define a nuclear pair model, that is, two composite hadrons interacting only through quark interchange and bound in an overall potential. An ''equivalent'' hadron model is developed, displaying an effective hadron-hadron interaction which is strongly repulsive. We compare the effective hadron model results with the exact quark model observables in the kinematic region of large momentum transfer, small energy transfer. The nucleon reponse function in this y-scaling region is, within the traditional frame work sensitive to the nucleon momentum distribution at large momentum. We find a surprizingly small effect of hadron substructure. Furthermore, we find in our model that a simple parametrization of modified hadron size in the bound state, motivated by the bound quark momentum distribution, is not a useful way to correlate different observables

  19. A simple hysteretic constitutive model for unsaturated flow

    OpenAIRE

    Soldi, Mariangeles; Guarracino, Luis; Jougnot, Damien

    2017-01-01

    In this paper we present a constitutive model to describe unsaturated flow that considers the hysteresis phenomena. This constitutive model provides simple mathematical expressions for both saturation and hydraulic conductivity curves, and a relationship between permeability and porosity. The model is based on the assumption that the porous media can be represented by a bundle of capillary tubes with throats or "ink-bottles" and a fractal pore size distribution. Under these hypotheses, hyster...

  20. Simple Flows of Pseudoplastic Fluids Based on Dehaven Model

    Directory of Open Access Journals (Sweden)

    Walicka A.

    2017-12-01

    Full Text Available In this paper three simple flows of visco-plastic fluids of DeHaven type or fluids similar to them are considered. These flows are: Poiseuille flow in a plane channel, Poiseuille flow through a circular pipe and rotating Couette flow between two coaxial cylinders. After presentation DeHaven model it was presented some models of fluids similar to this model. Next it was given the solutions of equations of motion for three flows mentioned above.

  1. Simple Flows of Pseudoplastic Fluids Based on Dehaven Model

    Science.gov (United States)

    Walicka, A.

    2017-12-01

    In this paper three simple flows of visco-plastic fluids of DeHaven type or fluids similar to them are considered. These flows are: Poiseuille flow in a plane channel, Poiseuille flow through a circular pipe and rotating Couette flow between two coaxial cylinders. After presentation DeHaven model it was presented some models of fluids similar to this model. Next it was given the solutions of equations of motion for three flows mentioned above.

  2. Can simple population genetic models reconcile partial match ...

    Indian Academy of Sciences (India)

    A recent study of partial matches in the Arizona offender database of DNA profiles has revealed a large number of nine and ten locus matches. I use simple models that incorporate the product rule, population substructure, and relatedness to predict the expected number of matches in large databases. I find that there is a ...

  3. Simple suggestions for including vertical physics in oil spill models

    International Nuclear Information System (INIS)

    D'Asaro, Eric; University of Washington, Seatle, WA

    2001-01-01

    Current models of oil spills include no vertical physics. They neglect the effect of vertical water motions on the transport and concentration of floating oil. Some simple ways to introduce vertical physics are suggested here. The major suggestion is to routinely measure the density stratification of the upper ocean during oil spills in order to develop a database on the effect of stratification. (Author)

  4. Modelling, Construction, and Testing of a Simple HTS Machine Demonstrator

    DEFF Research Database (Denmark)

    Jensen, Bogi Bech; Abrahamsen, Asger Bech

    2011-01-01

    This paper describes the construction, modeling and experimental testing of a high temperature superconducting (HTS) machine prototype employing second generation (2G) coated conductors in the field winding. The prototype is constructed in a simple way, with the purpose of having an inexpensive way...

  5. Simple model with damping of the mode-coupling instability

    Energy Technology Data Exchange (ETDEWEB)

    Pestrikov, D.V. [AN SSSR, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki

    1996-08-01

    In this paper we use a simple model to study the suppression of the transverse mode-coupling instability. Two possibilities are considered. One is due to the damping of particular synchrobetatron modes, and another - due to Landau damping, caused by the nonlinearity of betatron oscillations. (author)

  6. A simple stochastic weather generator for ecological modeling

    Science.gov (United States)

    A.G. Birt; M.R. Valdez-Vivas; R.M. Feldman; C.W. Lafon; D. Cairns; R.N. Coulson; M. Tchakerian; W. Xi; Jim Guldin

    2010-01-01

    Stochastic weather generators are useful tools for exploring the relationship between organisms and their environment. This paper describes a simple weather generator that can be used in ecological modeling projects. We provide a detailed description of methodology, and links to full C++ source code (http://weathergen.sourceforge.net) required to implement or modify...

  7. A simple statistical signal loss model for deep underground garage

    DEFF Research Database (Denmark)

    Nguyen, Huan Cong; Gimenez, Lucas Chavarria; Kovacs, Istvan

    2016-01-01

    In this paper we address the channel modeling aspects for a deep-indoor scenario with extreme coverage conditions in terms of signal losses, namely underground garage areas. We provide an in-depth analysis in terms of path loss (gain) and large scale signal shadowing, and a propose simple...

  8. A Simple Mathematical Model of Cyclic Circadian Learning

    Directory of Open Access Journals (Sweden)

    J. Šimon

    2014-01-01

    Full Text Available This paper deals with the derivation of a simple mathematical model of cyclic learning with a period of 24 hours. Various requirements are met with an emphasis and approach which relies on simple mathematical operations, the prediction of measurable quantities, and the creation of uncomplicated processes of calibration. The presented model can be used to answer questions such as the following. Will I be able to memorize a given set of information? How long will it take to memorize information? How long will I remember the information that was memorized? The model is based on known memory retention functions that are in good agreement with experimental results. By the use of these functions and by formalism of differential equations, the concurrent processes of learning and forgetting are described mathematically. The usability of this model is limited to scenarios where logical bonds (connections to prior learning are not created and mnemonic devices cannot be utilized during the learning process.

  9. Simple is beautiful ? Building a simple climate model for modelling archaeological issues

    OpenAIRE

    Saqalli , Mehdi

    2015-01-01

    International audience; Archaeological and paleo-environmental models do not focus on climatology dynamics but need to integrate climate evolutions within their simulations of Archaeological and paleo-environmental models do not focus on climatology dynamics but need to integrate climate evolutions within their simulations of human-environment issues.

  10. Simple model of surface roughness for binary collision sputtering simulations

    International Nuclear Information System (INIS)

    Lindsey, Sloan J.; Hobler, Gerhard; Maciążek, Dawid; Postawa, Zbigniew

    2017-01-01

    Highlights: • A simple model of surface roughness is proposed. • Its key feature is a linearly varying target density at the surface. • The model can be used in 1D/2D/3D Monte Carlo binary collision simulations. • The model fits well experimental glancing incidence sputtering yield data. - Abstract: It has been shown that surface roughness can strongly influence the sputtering yield – especially at glancing incidence angles where the inclusion of surface roughness leads to an increase in sputtering yields. In this work, we propose a simple one-parameter model (the “density gradient model”) which imitates surface roughness effects. In the model, the target’s atomic density is assumed to vary linearly between the actual material density and zero. The layer width is the sole model parameter. The model has been implemented in the binary collision simulator IMSIL and has been evaluated against various geometric surface models for 5 keV Ga ions impinging an amorphous Si target. To aid the construction of a realistic rough surface topography, we have performed MD simulations of sequential 5 keV Ga impacts on an initially crystalline Si target. We show that our new model effectively reproduces the sputtering yield, with only minor variations in the energy and angular distributions of sputtered particles. The success of the density gradient model is attributed to a reduction of the reflection coefficient – leading to increased sputtering yields, similar in effect to surface roughness.

  11. A simple double-source model for interference of capillaries

    International Nuclear Information System (INIS)

    Hou Zhibo; Zhao Xiaohong; Xiao Jinghua

    2012-01-01

    A simple but physically intuitive double-source model is proposed to explain the interferogram of a laser-capillary system, where two effective virtual sources are used to describe the rays reflected by and transmitted through the capillary. The locations of the two virtual sources are functions of the observing positions on the target screen. An inverse proportionality between the fringes spacing and the capillary radius is derived based on the simple double-source model. This can provide an efficient and precise method to measure a small capillary diameter of micrometre scale. This model could be useful because it presents a fresh perspective on the diffraction of light from a particular geometry (transparent cylinder), which is not straightforward for undergraduates. It also offers an alternative interferometer to perform a different type of measurement, especially for using virtual sources. (paper)

  12. The bumper bundle book of modelling NLP modelling made simple

    CERN Document Server

    Burgess, Fran

    2014-01-01

    A Neurolinguistic Programming textbook which focusses on the core activity of NLP - modelling. It covers the thinking behind NLP modelling, presents an extensive range of modelling methodologies and skills, offers applications of modelling, and provides specific details for model and technique construction.

  13. pyhector: A Python interface for the simple climate model Hector

    Energy Technology Data Exchange (ETDEWEB)

    N Willner, Sven; Hartin, Corinne; Gieseke, Robert

    2017-04-01

    Pyhector is a Python interface for the simple climate model Hector (Hartin et al. 2015) developed in C++. Simple climate models like Hector can, for instance, be used in the analysis of scenarios within integrated assessment models like GCAM1, in the emulation of complex climate models, and in uncertainty analyses. Hector is an open-source, object oriented, simple global climate carbon cycle model. Its carbon cycle consists of a one pool atmosphere, three terrestrial pools which can be broken down into finer biomes or regions, and four carbon pools in the ocean component. The terrestrial carbon cycle includes primary production and respiration fluxes. The ocean carbon cycle circulates carbon via a simplified thermohaline circulation, calculating air-sea fluxes as well as the marine carbonate system (Hartin et al. 2016). The model input is time series of greenhouse gas emissions; as example scenarios for these the Pyhector package contains the Representative Concentration Pathways (RCPs)2. These were developed to cover the range of baseline and mitigation emissions scenarios and are widely used in climate change research and model intercomparison projects. Using DataFrames from the Python library Pandas (McKinney 2010) as a data structure for the scenarios simplifies generating and adapting scenarios. Other parameters of the Hector model can easily be modified when running the model. Pyhector can be installed using pip from the Python Package Index.3 Source code and issue tracker are available in Pyhector's GitHub repository4. Documentation is provided through Readthedocs5. Usage examples are also contained in the repository as a Jupyter Notebook (Pérez and Granger 2007; Kluyver et al. 2016). Courtesy of the Mybinder project6, the example Notebook can also be executed and modified without installing Pyhector locally.

  14. Simple Predictive Models for Saturated Hydraulic Conductivity of Technosands

    DEFF Research Database (Denmark)

    Arthur, Emmanuel; Razzaghi, Fatemeh; Møldrup, Per

    2012-01-01

    Accurate estimation of saturated hydraulic conductivity (Ks) of technosands (gravel-free, coarse sands with negligible organic matter content) is important for irrigation and drainage management of athletic fields and golf courses. In this study, we developed two simple models for predicting Ks...... of technosands based on either (i) the classic Kozeny-Carman (K-C) model modified by considering the content of finer particles (fines) less than 200 [mu]m to estimate an immobile water fraction or (ii) the Revil-Cathles (R-C) model modified by using the characteristic particle diameter from the Rosin...

  15. Complex Behavior in Simple Models of Biological Coevolution

    Science.gov (United States)

    Rikvold, Per Arne

    We explore the complex dynamical behavior of simple predator-prey models of biological coevolution that account for interspecific and intraspecific competition for resources, as well as adaptive foraging behavior. In long kinetic Monte Carlo simulations of these models we find quite robust 1/f-like noise in species diversity and population sizes, as well as power-law distributions for the lifetimes of individual species and the durations of quiet periods of relative evolutionary stasis. In one model, based on the Holling Type II functional response, adaptive foraging produces a metastable low-diversity phase and a stable high-diversity phase.

  16. Simple Model for Describing and Estimating Wind Turbine Dynamic Inflow

    DEFF Research Database (Denmark)

    Knudsen, Torben; Bak, Thomas

    2013-01-01

    a method that can be characterised as the blade element momentum method plus a dynamic equation for the induction factor. This method then needs calculations along the blade for a number of sections including numerical solution of equations. This is numerical demanding. The simplest models amounts...... model suggested here places itself in between the most complex and the most simple both in accuracy, numerical demands and physical appeal. The suggested models behavior is demonstrated by simulation and the usefulness for extended Kalman filtering is assessed both via simulated data and real full scale...

  17. Linking Simple Economic Theory Models and the Cointegrated Vector AutoRegressive Model

    DEFF Research Database (Denmark)

    Møller, Niels Framroze

    This paper attempts to clarify the connection between simple economic theory models and the approach of the Cointegrated Vector-Auto-Regressive model (CVAR). By considering (stylized) examples of simple static equilibrium models, it is illustrated in detail, how the theoretical model and its...

  18. Development of simple kinetic models and parameter estimation for ...

    African Journals Online (AJOL)

    PANCHIGA

    2016-09-28

    Sep 28, 2016 ... by methanol. In this study, the unstructured models based on growth kinetic equation, fed-batch mass balance and constancy of cell and protein yields were developed and constructed following the substrates, glycerol and methanol. The growth model on glycerol is mostly published while the growth model ...

  19. A simple hyperbolic model for communication in parallel processing environments

    Science.gov (United States)

    Stoica, Ion; Sultan, Florin; Keyes, David

    1994-01-01

    We introduce a model for communication costs in parallel processing environments called the 'hyperbolic model,' which generalizes two-parameter dedicated-link models in an analytically simple way. Dedicated interprocessor links parameterized by a latency and a transfer rate that are independent of load are assumed by many existing communication models; such models are unrealistic for workstation networks. The communication system is modeled as a directed communication graph in which terminal nodes represent the application processes that initiate the sending and receiving of the information and in which internal nodes, called communication blocks (CBs), reflect the layered structure of the underlying communication architecture. The direction of graph edges specifies the flow of the information carried through messages. Each CB is characterized by a two-parameter hyperbolic function of the message size that represents the service time needed for processing the message. The parameters are evaluated in the limits of very large and very small messages. Rules are given for reducing a communication graph consisting of many to an equivalent two-parameter form, while maintaining an approximation for the service time that is exact in both large and small limits. The model is validated on a dedicated Ethernet network of workstations by experiments with communication subprograms arising in scientific applications, for which a tight fit of the model predictions with actual measurements of the communication and synchronization time between end processes is demonstrated. The model is then used to evaluate the performance of two simple parallel scientific applications from partial differential equations: domain decomposition and time-parallel multigrid. In an appropriate limit, we also show the compatibility of the hyperbolic model with the recently proposed LogP model.

  20. Climate stability and sensitivity in some simple conceptual models

    Energy Technology Data Exchange (ETDEWEB)

    Bates, J. Ray [University College Dublin, Meteorology and Climate Centre, School of Mathematical Sciences, Dublin (Ireland)

    2012-02-15

    A theoretical investigation of climate stability and sensitivity is carried out using three simple linearized models based on the top-of-the-atmosphere energy budget. The simplest is the zero-dimensional model (ZDM) commonly used as a conceptual basis for climate sensitivity and feedback studies. The others are two-zone models with tropics and extratropics of equal area; in the first of these (Model A), the dynamical heat transport (DHT) between the zones is implicit, in the second (Model B) it is explicitly parameterized. It is found that the stability and sensitivity properties of the ZDM and Model A are very similar, both depending only on the global-mean radiative response coefficient and the global-mean forcing. The corresponding properties of Model B are more complex, depending asymmetrically on the separate tropical and extratropical values of these quantities, as well as on the DHT coefficient. Adopting Model B as a benchmark, conditions are found under which the validity of the ZDM and Model A as climate sensitivity models holds. It is shown that parameter ranges of physical interest exist for which such validity may not hold. The 2 x CO{sub 2} sensitivities of the simple models are studied and compared. Possible implications of the results for sensitivities derived from GCMs and palaeoclimate data are suggested. Sensitivities for more general scenarios that include negative forcing in the tropics (due to aerosols, inadvertent or geoengineered) are also studied. Some unexpected outcomes are found in this case. These include the possibility of a negative global-mean temperature response to a positive global-mean forcing, and vice versa. (orig.)

  1. Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module.

    Science.gov (United States)

    McIlrath, Victoria; Trye, Alice; Aguanno, Ann

    2015-06-18

    Undergraduate biology students are required to learn, understand and apply a variety of cellular and molecular biology concepts and techniques in preparation for biomedical, graduate and professional programs or careers in science. To address this, a simple laboratory module was devised to teach the concepts of cell division, cellular communication and cancer through the application of animal cell culture techniques. Here the mouse mammary tumor (MMT) cell line is used to model for breast cancer. Students learn to grow and characterize these animal cells in culture and test the effects of traditional and non-traditional chemotherapy agents on cell proliferation. Specifically, students determine the optimal cell concentration for plating and growing cells, learn how to prepare and dilute drug solutions, identify the best dosage and treatment time course of the antiproliferative agents, and ascertain the rate of cell death in response to various treatments. The module employs both a standard cell counting technique using a hemocytometer and a novel cell counting method using microscopy software. The experimental procedure lends to open-ended inquiry as students can modify critical steps of the protocol, including testing homeopathic agents and over-the-counter drugs. In short, this lab module requires students to use the scientific process to apply their knowledge of the cell cycle, cellular signaling pathways, cancer and modes of treatment, all while developing an array of laboratory skills including cell culture and analysis of experimental data not routinely taught in the undergraduate classroom.

  2. A simple model for the dynamic analysis of deteriorating structures

    International Nuclear Information System (INIS)

    Andreaus, U.; Ceradini, G.; D'Asdia, P.

    1983-01-01

    A simple model exhibiting a multi-linear constitutive law is presented which describes the behaviour of structural members and subassemblages under severe cyclic loading. The proposed model allows for: 1) pinched form of force-displacement diagrams due to, e.g., cracks in reinforced concrete members and masonry panels; 2) slippage effects due to lack of bond of steel bars in reinforced concrete and clearances in steel bolted connections; 3) post-buckling behaviour of subassemblages with unstable members; 4) cumulative damage affecting strength and/or stiffness at low cycle fatigue. The parameters governing the model behaviour have to be estimated on the basis of experimental results. The model is well suitable for analysis under statically applied cyclic displacements and forces, and under earthquake excitation. An X-type bracing system is then worked out where the member behaviour is schematized according to the proposed model. (orig.)

  3. Simple Numerical Model to Simulate Penetration Testing in Unsaturated Soils

    Directory of Open Access Journals (Sweden)

    Jarast S. Pegah

    2016-01-01

    Full Text Available Cone penetration test in unsaturated sand is modelled numerically using Finite Element Method. Simple elastic-perfectly plastic Mohr-Coulomb constitutive model is modified with an apparent cohesion to incorporate the effect of suction on cone resistance. The Arbitrary Lagrangian-Eulerian (ALE remeshing algorithm is also implemented to avoid mesh distortion problem due to the large deformation in the soil around the cone tip. The simulated models indicate that the cone resistance was increased consistently under higher suction or lower degree of saturation. Sensitivity analysis investigating the effect of input soil parameters on the cone tip resistance shows that unsaturated soil condition can be adequately modelled by incorporating the apparent cohesion concept. However, updating the soil stiffness by including a suction-dependent effective stress formula in Mohr-Coulomb material model does not influence the cone resistance significantly.

  4. A Simple Hybrid Model for Short-Term Load Forecasting

    Directory of Open Access Journals (Sweden)

    Suseelatha Annamareddi

    2013-01-01

    Full Text Available The paper proposes a simple hybrid model to forecast the electrical load data based on the wavelet transform technique and double exponential smoothing. The historical noisy load series data is decomposed into deterministic and fluctuation components using suitable wavelet coefficient thresholds and wavelet reconstruction method. The variation characteristics of the resulting series are analyzed to arrive at reasonable thresholds that yield good denoising results. The constitutive series are then forecasted using appropriate exponential adaptive smoothing models. A case study performed on California energy market data demonstrates that the proposed method can offer high forecasting precision for very short-term forecasts, considering a time horizon of two weeks.

  5. A simple probabilistic model of multibody interactions in proteins

    DEFF Research Database (Denmark)

    Johansson, Kristoffer Enøe; Hamelryck, Thomas

    2013-01-01

    Protein structure prediction methods typically use statistical potentials, which rely on statistics derived from a database of know protein structures. In the vast majority of cases, these potentials involve pairwise distances or contacts between amino acids or atoms. Although some potentials...... arbitrarily limiting the number of contacts. The success of this approach is based on replacing a naive table-based approach with a simple hierarchical model involving suitable probability distributions and conditional independence assumptions. The model captures the joint probability distribution of an amino...

  6. A simple-source model of military jet aircraft noise

    Science.gov (United States)

    Morgan, Jessica; Gee, Kent L.; Neilsen, Tracianne; Wall, Alan T.

    2010-10-01

    The jet plumes produced by military jet aircraft radiate significant amounts of noise. A need to better understand the characteristics of the turbulence-induced aeroacoustic sources has motivated the present study. The purpose of the study is to develop a simple-source model of jet noise that can be compared to the measured data. The study is based off of acoustic data collected near a tied-down F-22 Raptor. The simplest model consisted of adjusting the origin of a monopole above a rigid planar reflector until the locations of the predicted and measured interference nulls matched. The model has developed into an extended Rayleigh distribution of partially correlated monopoles which fits the measured data from the F-22 significantly better. The results and basis for the model match the current prevailing theory that jet noise consists of both correlated and uncorrelated sources. In addition, this simple-source model conforms to the theory that the peak source location moves upstream with increasing frequency and lower engine conditions.

  7. A Simple theoretical model for 63Ni betavoltaic battery

    International Nuclear Information System (INIS)

    ZUO, Guoping; ZHOU, Jianliang; KE, Guotu

    2013-01-01

    A numerical simulation of the energy deposition distribution in semiconductors is performed for 63 Ni beta particles. Results show that the energy deposition distribution exhibits an approximate exponential decay law. A simple theoretical model is developed for 63 Ni betavoltaic battery based on the distribution characteristics. The correctness of the model is validated by two literature experiments. Results show that the theoretical short-circuit current agrees well with the experimental results, and the open-circuit voltage deviates from the experimental results in terms of the influence of the PN junction defects and the simplification of the source. The theoretical model can be applied to 63 Ni and 147 Pm betavoltaic batteries. - Highlights: • The energy deposition distribution is found following an approximate exponential decay law when beta particles emitted from 63 Ni pass through a semiconductor. • A simple theoretical model for 63 Ni betavoltaic battery is constructed based on the exponential decay law. • Theoretical model can be applied to the betavoltaic batteries which radioactive source has a similar energy spectrum with 63 Ni, such as 147 Pm

  8. Computing local edge probability in natural scenes from a population of oriented simple cells.

    Science.gov (United States)

    Ramachandra, Chaithanya A; Mel, Bartlett W

    2013-12-31

    A key computation in visual cortex is the extraction of object contours, where the first stage of processing is commonly attributed to V1 simple cells. The standard model of a simple cell-an oriented linear filter followed by a divisive normalization-fits a wide variety of physiological data, but is a poor performing local edge detector when applied to natural images. The brain's ability to finely discriminate edges from nonedges therefore likely depends on information encoded by local simple cell populations. To gain insight into the corresponding decoding problem, we used Bayes's rule to calculate edge probability at a given location/orientation in an image based on a surrounding filter population. Beginning with a set of ∼ 100 filters, we culled out a subset that were maximally informative about edges, and minimally correlated to allow factorization of the joint on- and off-edge likelihood functions. Key features of our approach include a new, efficient method for ground-truth edge labeling, an emphasis on achieving filter independence, including a focus on filters in the region orthogonal rather than tangential to an edge, and the use of a customized parametric model to represent the individual filter likelihood functions. The resulting population-based edge detector has zero parameters, calculates edge probability based on a sum of surrounding filter influences, is much more sharply tuned than the underlying linear filters, and effectively captures fine-scale edge structure in natural scenes. Our findings predict nonmonotonic interactions between cells in visual cortex, wherein a cell may for certain stimuli excite and for other stimuli inhibit the same neighboring cell, depending on the two cells' relative offsets in position and orientation, and their relative activation levels.

  9. Modelling of damping forces occuring in simple MEMS systems

    Directory of Open Access Journals (Sweden)

    Kamil Urbanowicz

    2015-12-01

    Full Text Available A certain damping force occurs in the micro-mechanical systems referred as MEMS. At the design stage of such systems, these forces must be accurately estimated. As shown in this work, in all systems operating at low frequencies, most important force is the one associated with the flotation of air film from the volume between two parallel operating movable MEMS plates. This force can be accurately estimated by analytical methods known from the literature. The paper presents analytical solutions that are frequently used in practice for simple plates. Also some simple simulations, using all described analytical solutions compared with the results of specialized program called Comsol Multyphysics, are shown. Presented research demonstrate the effectiveness of numerical software.[b]Keywords[/b]: MEMS, damping forces, Reynolds equation, modelling, simulation

  10. A simple model of low-scale direct gauge mediation

    International Nuclear Information System (INIS)

    Csaki, Csaba; Shirman, Yuri; Terning, John

    2007-01-01

    We construct a calculable model of low-energy direct gauge mediation making use of the metastable supersymmetry breaking vacua recently discovered by Intriligator, Seiberg and Shih. The standard model gauge group is a subgroup of the global symmetries of the SUSY breaking sector and messengers play an essential role in dynamical SUSY breaking: they are composites of a confining gauge theory, and the holomorphic scalar messenger mass appears as a consequence of the confining dynamics. The SUSY breaking scale is around 100 TeV nevertheless the model is calculable. The minimal non-renormalizable coupling of the Higgs to the DSB sector leads in a simple way to a μ-term, while the B-term arises at two-loop order resulting in a moderately large tan β. A novel feature of this class of models is that some particles from the dynamical SUSY breaking sector may be accessible at the LHC

  11. A simple generative model of collective online behavior.

    Science.gov (United States)

    Gleeson, James P; Cellai, Davide; Onnela, Jukka-Pekka; Porter, Mason A; Reed-Tsochas, Felix

    2014-07-22

    Human activities increasingly take place in online environments, providing novel opportunities for relating individual behaviors to population-level outcomes. In this paper, we introduce a simple generative model for the collective behavior of millions of social networking site users who are deciding between different software applications. Our model incorporates two distinct mechanisms: one is associated with recent decisions of users, and the other reflects the cumulative popularity of each application. Importantly, although various combinations of the two mechanisms yield long-time behavior that is consistent with data, the only models that reproduce the observed temporal dynamics are those that strongly emphasize the recent popularity of applications over their cumulative popularity. This demonstrates--even when using purely observational data without experimental design--that temporal data-driven modeling can effectively distinguish between competing microscopic mechanisms, allowing us to uncover previously unidentified aspects of collective online behavior.

  12. A simple model for calculating air pollution within street canyons

    Science.gov (United States)

    Venegas, Laura E.; Mazzeo, Nicolás A.; Dezzutti, Mariana C.

    2014-04-01

    This paper introduces the Semi-Empirical Urban Street (SEUS) model. SEUS is a simple mathematical model based on the scaling of air pollution concentration inside street canyons employing the emission rate, the width of the canyon, the dispersive velocity scale and the background concentration. Dispersive velocity scale depends on turbulent motions related to wind and traffic. The parameterisations of these turbulent motions include two dimensionless empirical parameters. Functional forms of these parameters have been obtained from full scale data measured in street canyons at four European cities. The sensitivity of SEUS model is studied analytically. Results show that relative errors in the evaluation of the two dimensionless empirical parameters have less influence on model uncertainties than uncertainties in other input variables. The model estimates NO2 concentrations using a simple photochemistry scheme. SEUS is applied to estimate NOx and NO2 hourly concentrations in an irregular and busy street canyon in the city of Buenos Aires. The statistical evaluation of results shows that there is a good agreement between estimated and observed hourly concentrations (e.g. fractional bias are -10.3% for NOx and +7.8% for NO2). The agreement between the estimated and observed values has also been analysed in terms of its dependence on wind speed and direction. The model shows a better performance for wind speeds >2 m s-1 than for lower wind speeds and for leeward situations than for others. No significant discrepancies have been found between the results of the proposed model and that of a widely used operational dispersion model (OSPM), both using the same input information.

  13. Simple model for fine particle (dust) clouds in plasmas

    International Nuclear Information System (INIS)

    Totsuji, Hiroo

    2016-01-01

    Highlights: • Simple model of fine particle clouds in plasmas is proposed. • The model enables independent control of the size and the density. • The system with cylindrical or spherical symmetry under microgravity is treated. • The model is based on the enhanced charge neutrality in fine particle clouds. - Abstract: In the cloud of fine particles (dusts) in plasmas, the charge neutrality can be much enhanced due to large charge numbers of fine particles. The required condition is not difficult to satisfy even when their charge density is substantially smaller than electrons or ions. Based on this fact, a simple model of fine particle clouds is proposed and the cloud radius is related to the half-width, the radius where the density of surrounding plasmas drops by half, in cylindrically and spherically symmetric cases under microgravity. When fine particles are gradually introduced with parameters of surrounding plasma especially the half-width being fixed, the size of clouds first increases and then saturates at the value determined by the plasma half-width, giving a possibility to control the size and density of clouds independently.

  14. Characteristics and Properties of a Simple Linear Regression Model

    Directory of Open Access Journals (Sweden)

    Kowal Robert

    2016-12-01

    Full Text Available A simple linear regression model is one of the pillars of classic econometrics. Despite the passage of time, it continues to raise interest both from the theoretical side as well as from the application side. One of the many fundamental questions in the model concerns determining derivative characteristics and studying the properties existing in their scope, referring to the first of these aspects. The literature of the subject provides several classic solutions in that regard. In the paper, a completely new design is proposed, based on the direct application of variance and its properties, resulting from the non-correlation of certain estimators with the mean, within the scope of which some fundamental dependencies of the model characteristics are obtained in a much more compact manner. The apparatus allows for a simple and uniform demonstration of multiple dependencies and fundamental properties in the model, and it does it in an intuitive manner. The results were obtained in a classic, traditional area, where everything, as it might seem, has already been thoroughly studied and discovered.

  15. Simple model for fine particle (dust) clouds in plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Totsuji, Hiroo, E-mail: totsuji-09@t.okadai.jp

    2016-04-01

    Highlights: • Simple model of fine particle clouds in plasmas is proposed. • The model enables independent control of the size and the density. • The system with cylindrical or spherical symmetry under microgravity is treated. • The model is based on the enhanced charge neutrality in fine particle clouds. - Abstract: In the cloud of fine particles (dusts) in plasmas, the charge neutrality can be much enhanced due to large charge numbers of fine particles. The required condition is not difficult to satisfy even when their charge density is substantially smaller than electrons or ions. Based on this fact, a simple model of fine particle clouds is proposed and the cloud radius is related to the half-width, the radius where the density of surrounding plasmas drops by half, in cylindrically and spherically symmetric cases under microgravity. When fine particles are gradually introduced with parameters of surrounding plasma especially the half-width being fixed, the size of clouds first increases and then saturates at the value determined by the plasma half-width, giving a possibility to control the size and density of clouds independently.

  16. A simple model for simultaneous methanogenic-denitrification systems

    DEFF Research Database (Denmark)

    Garibay-Orijel, C.; Ahring, Birgitte Kiær; Rinderknecht-Seijas, N.

    2006-01-01

    We describe a useful and simple model for studies of simultaneous methanogenic-denitrification (M-D) systems. One equation predicts an inverse relationship between the percentage of electron donor channeled into dissimilatory denitrification and the loading ratio X given by grams degradable COD per...... gram nitrate-N in the influent. It allows the determination of the extent of use of organic matter by the denitrification and the methanogenic pathways for a given concentration of nitrate salts in the influent. This equation was validated with experimental data from the literature and good agreement...

  17. Simple model for the dynamics towards metastable states

    International Nuclear Information System (INIS)

    Meijer, P.H.E.; Keskin, M.; Bodegom, E.

    1986-01-01

    Circumstances under which a quenched system will freeze in a metastable state are studied in simple systems with long-range order. The model used is the time-dependent pair approximation, based on the most probable path (MPP) method. The time dependence of the solution is shown by means of flow diagrams. The fixed points and other features of the differential equations in time are independent of the choice of the rate constants. It is explained qualitatively how the system behaves under varying descending temperatures: the role of the initial conditions, the dependence on the quenching rate, and the response to precooling

  18. A simple hydrodynamic model of tornado-like vortices

    Science.gov (United States)

    Kurgansky, M. V.

    2015-05-01

    Based on similarity arguments, a simple fluid dynamic model of tornado-like vortices is offered that, with account for "vortex breakdown" at a certain height above the ground, relates the maximal azimuthal velocity in the vortex, reachable near the ground surface, to the convective available potential energy (CAPE) stored in the environmental atmosphere under pre-tornado conditions. The relative proportion of the helicity (kinetic energy) destruction (dissipation) in the "vortex breakdown" zone and, accordingly, within the surface boundary layer beneath the vortex is evaluated. These considerations form the basis of the dynamic-statistical analysis of the relationship between the tornado intensity and the CAPE budget in the surrounding atmosphere.

  19. A simple model for low energy ion-solid interactions

    International Nuclear Information System (INIS)

    Mohajerzadeh, S.; Selvakumar, C.R.

    1997-01-01

    A simple analytical model for ion-solid interactions, suitable for low energy beam depositions, is reported. An approximation for the nuclear stopping power is used to obtain the analytic solution for the deposited energy in the solid. The ratio of the deposited energy in the bulk to the energy deposited in the surface yields a ceiling for the beam energy above which more defects are generated in the bulk resulting in defective films. The numerical evaluations agree with the existing results in the literature. copyright 1997 American Institute of Physics

  20. Simple Models Create Steep Learning Curves in Academic Design Studio

    DEFF Research Database (Denmark)

    Hansen, Peter Lundsgaard; Dam, Torben; Le Goffic, Virginie Corinne

    2014-01-01

    This paper presents an easily adaptable, very learning-efficient and solution-oriented design studio method: ‘the simple model method’. On a practical level it solves well known problems that occur when teaching design studios. On a theoretical level it suggests a ‘third way’ of bridging design...... theory positions normally regarded as mutually incompatible. The method is the result of years of ‘trial and error’ design studio teaching at the University of Copenhagen, triangulated with academic design theory research. Research based design studio teaching poses a fundamental pedagogical challenge...

  1. A Simple Model of the Variability of Soil Depths

    Directory of Open Access Journals (Sweden)

    Fang Yu

    2017-06-01

    Full Text Available Soil depth tends to vary from a few centimeters to several meters, depending on many natural and environmental factors. We hypothesize that the cumulative effect of these factors on soil depth, which is chiefly dependent on the process of biogeochemical weathering, is particularly affected by soil porewater (i.e., solute transport and infiltration from the land surface. Taking into account evidence for a non-Gaussian distribution of rock weathering rates, we propose a simple mathematical model to describe the relationship between soil depth and infiltration flux. The model was tested using several areas in mostly semi-arid climate zones. The application of this model demonstrates the use of fundamental principles of physics to quantify the coupled effects of the five principal soil-forming factors of Dokuchaev.

  2. A simple model for skewed species-lifetime distributions

    KAUST Repository

    Murase, Yohsuke

    2010-06-11

    A simple model of a biological community assembly is studied. Communities are assembled by successive migrations and extinctions of species. In the model, species are interacting with each other. The intensity of the interaction between each pair of species is denoted by an interaction coefficient. At each time step, a new species is introduced to the system with randomly assigned interaction coefficients. If the sum of the coefficients, which we call the fitness of a species, is negative, the species goes extinct. The species-lifetime distribution is found to be well characterized by a stretched exponential function with an exponent close to 1/2. This profile agrees not only with more realistic population dynamics models but also with fossil records. We also find that an age-independent and inversely diversity-dependent mortality, which is confirmed in the simulation, is a key mechanism accounting for the distribution. © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft.

  3. Simple model for phonon dispersion of nonstoichiometric transition metal carbides

    International Nuclear Information System (INIS)

    Splettstoesser, B.

    1977-09-01

    The simple shell model for the acoustic dispersion curves of ideal and nonstoichiometric Niobium Carbide is presented. The main emphasis is put on a qualitative understanding of the rather sharp dips, observed in some of the branches, and, in particular, their extreme sensitivity to C-vacancies. For comparison the 'normal' acoustic dispersion curves of TiC - which can be described with the same model - and their weak stoichiometry dependence are investigated. For both materials the one phonon cross section of the defect crystal is calculated in various approximations. The obtained phonon shifts and broadenings are small for TiC, but large for NbC in the dip regions - in good agreement with experimental results. Both, the dip structure observed for TaC and the 'normal' acoustic dispersion curves of HfC, ZrC can be described with our model as well. (orig.) [de

  4. Simple model for low-frequency guitar function

    DEFF Research Database (Denmark)

    Christensen, Ove; Vistisen, Bo B.

    1980-01-01

    - frequency guitar function. The model predicts frequency responce of sound pressure and top plate mobility which are in close quantitative agreement with experimental responses. The absolute sound pressure level and mobility level are predicted to within a few decibels, and the equivalent piston area......The frequency response of sound pressure and top plate mobility is studied around the two first resonances of the guitar. These resonances are shown to result from a coupling between the fundamental top plate mode and the Helmholtz resonance of the cavity. A simple model is proposed for low...... of the top plate is determined. All parameters of this model can directly be derived from measurements of the frequencies of the two first resonances and of the cavity Helmholtz resonance. The Helmholtz resonance is found as the antiresonance in the spectrum of top plate mobility....

  5. Simple model of surface roughness for binary collision sputtering simulations

    Science.gov (United States)

    Lindsey, Sloan J.; Hobler, Gerhard; Maciążek, Dawid; Postawa, Zbigniew

    2017-02-01

    It has been shown that surface roughness can strongly influence the sputtering yield - especially at glancing incidence angles where the inclusion of surface roughness leads to an increase in sputtering yields. In this work, we propose a simple one-parameter model (the "density gradient model") which imitates surface roughness effects. In the model, the target's atomic density is assumed to vary linearly between the actual material density and zero. The layer width is the sole model parameter. The model has been implemented in the binary collision simulator IMSIL and has been evaluated against various geometric surface models for 5 keV Ga ions impinging an amorphous Si target. To aid the construction of a realistic rough surface topography, we have performed MD simulations of sequential 5 keV Ga impacts on an initially crystalline Si target. We show that our new model effectively reproduces the sputtering yield, with only minor variations in the energy and angular distributions of sputtered particles. The success of the density gradient model is attributed to a reduction of the reflection coefficient - leading to increased sputtering yields, similar in effect to surface roughness.

  6. A simple bipedal model for studying control of gait termination.

    Science.gov (United States)

    Suzuki, Yasuyuki; Geyer, Hartmut

    2018-03-27

    We study the control of human gait termination with a simple bipedal locomotion model. Several control strategies have been proposed for gait termination. However, the relative importance of these strategies has not been evaluated in models of human gait. Here we extend the bipedal spring mass walking model in a least parameter fashion and study three explicit control strategies for gait termination, including the shortening of the final step, braking at the ankle, and extending the knee. Applying the strategies separately, we find that only braking at the ankle reduces the propulsive force enough to transition into quiet standing. In combination with the other two strategies, we observe that the range of control parameters suitable for gait termination increases, especially when the ankle control is applied intermittently by taking advantage of passive stabilizing dynamics. We further show the resulting model behavior is compatible with several experimental observations about the human center of mass dynamics and leg forces during gait termination, and discuss model improvements to correct mismatches. The proposed model may serve as a starting point for more advanced models that can provide a deeper understanding of human control strategies during gait termination.

  7. Oscillations in a simple climate–vegetation model

    Directory of Open Access Journals (Sweden)

    J. Rombouts

    2015-05-01

    Full Text Available We formulate and analyze a simple dynamical systems model for climate–vegetation interaction. The planet we consider consists of a large ocean and a land surface on which vegetation can grow. The temperature affects vegetation growth on land and the amount of sea ice on the ocean. Conversely, vegetation and sea ice change the albedo of the planet, which in turn changes its energy balance and hence the temperature evolution. Our highly idealized, conceptual model is governed by two nonlinear, coupled ordinary differential equations, one for global temperature, the other for vegetation cover. The model exhibits either bistability between a vegetated and a desert state or oscillatory behavior. The oscillations arise through a Hopf bifurcation off the vegetated state, when the death rate of vegetation is low enough. These oscillations are anharmonic and exhibit a sawtooth shape that is characteristic of relaxation oscillations, as well as suggestive of the sharp deglaciations of the Quaternary. Our model's behavior can be compared, on the one hand, with the bistability of even simpler, Daisyworld-style climate–vegetation models. On the other hand, it can be integrated into the hierarchy of models trying to simulate and explain oscillatory behavior in the climate system. Rigorous mathematical results are obtained that link the nature of the feedbacks with the nature and the stability of the solutions. The relevance of model results to climate variability on various timescales is discussed.

  8. Mass and Heat Transfer Analysis of Membrane Humidifier with a Simple Lumped Mass Model

    International Nuclear Information System (INIS)

    Lee, Young Duk; Bae, Ho June; Ahn, Kook Young; Yu, Sang Seok; Hwang, Joon Young

    2009-01-01

    The performance of proton exchange membrane fuel cell (PEMFC) is seriously changed by the humidification condition which is intrinsic characteristics of the PEMFC. Typically, the humidification of fuel cell is carried out with internal or external humidifier. A membrane humidifier is applied to the external humidification of residential power generation fuel cell due to its convenience and high performance. In this study, a simple static model is constructed to understand the physical phenomena of the membrane humidifier in terms of geometric parameters and operating parameters. The model utilizes the concept of shell and tube heat exchanger but the model is also able to estimate the mass transport through the membrane. Model is constructed with FORTRAN under Matlab/Simulink □ environment to keep consistency with other components model which we already developed. Results shows that the humidity of wet gas and membrane thickness are critical parameters to improve the performance of the humidifier

  9. Simple Mathematical Models Do Not Accurately Predict Early SIV Dynamics

    Directory of Open Access Journals (Sweden)

    Cecilia Noecker

    2015-03-01

    Full Text Available Upon infection of a new host, human immunodeficiency virus (HIV replicates in the mucosal tissues and is generally undetectable in circulation for 1–2 weeks post-infection. Several interventions against HIV including vaccines and antiretroviral prophylaxis target virus replication at this earliest stage of infection. Mathematical models have been used to understand how HIV spreads from mucosal tissues systemically and what impact vaccination and/or antiretroviral prophylaxis has on viral eradication. Because predictions of such models have been rarely compared to experimental data, it remains unclear which processes included in these models are critical for predicting early HIV dynamics. Here we modified the “standard” mathematical model of HIV infection to include two populations of infected cells: cells that are actively producing the virus and cells that are transitioning into virus production mode. We evaluated the effects of several poorly known parameters on infection outcomes in this model and compared model predictions to experimental data on infection of non-human primates with variable doses of simian immunodifficiency virus (SIV. First, we found that the mode of virus production by infected cells (budding vs. bursting has a minimal impact on the early virus dynamics for a wide range of model parameters, as long as the parameters are constrained to provide the observed rate of SIV load increase in the blood of infected animals. Interestingly and in contrast with previous results, we found that the bursting mode of virus production generally results in a higher probability of viral extinction than the budding mode of virus production. Second, this mathematical model was not able to accurately describe the change in experimentally determined probability of host infection with increasing viral doses. Third and finally, the model was also unable to accurately explain the decline in the time to virus detection with increasing viral

  10. Simple evaluation method for osteoinductive capacity of cells or scaffolds using ceramic cubes.

    Science.gov (United States)

    Song, In-Hwan; Dennis, James E

    2014-10-01

    Mesenchymal stem cells are good candidates for the clinical application of bone repair because of their osteogenic differentiation potential, but in vivo osteoinduction potential should be verified for culture expanded cells before clinical application. This study analyzed in vivo bone formation by MSCs quantitatively after implantation of MSCs planted porous biphasic ceramic cubes into athymic mice. MSCs were divided into osteogenic differentiation-induced and normal groups and also tested in vitro to evaluate the degree of differentiation into osteoblasts. The osteogenic induced group showed higher alkaline phosphatase and calcium level in vitro and corresponding higher level of bone formation in vivo compared to control group. Whereas there was no bone formation observed in fibroblast-implanted negative control group. In critical sized bone defect models, commonly used for evaluation of bone regeneration ability, it is difficult to distinguish between osteoinduction and osteoconduction, and quantitative analysis is not simple. However, this method for evaluating osteoinduction is both accurate and simple. In conclusion, the analysis of in vivo bone formation using porous ceramic cubes is a powerful and simple method for evaluating the osteoinduction ability of target cells and, furthermore, can be applied for evaluation of scaffolds for their osteoinductive properties. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. A simple model for behaviour change in epidemics

    Directory of Open Access Journals (Sweden)

    Brauer Fred

    2011-02-01

    Full Text Available Abstract Background People change their behaviour during an epidemic. Infectious members of a population may reduce the number of contacts they make with other people because of the physical effects of their illness and possibly because of public health announcements asking them to do so in order to decrease the number of new infections, while susceptible members of the population may reduce the number of contacts they make in order to try to avoid becoming infected. Methods We consider a simple epidemic model in which susceptible and infectious members respond to a disease outbreak by reducing contacts by different fractions and analyze the effect of such contact reductions on the size of the epidemic. We assume constant fractional reductions, without attempting to consider the way in which susceptible members might respond to information about the epidemic. Results We are able to derive upper and lower bounds for the final size of an epidemic, both for simple and staged progression models. Conclusions The responses of uninfected and infected individuals in a disease outbreak are different, and this difference affects estimates of epidemic size.

  12. Stochastic models for cell division

    Science.gov (United States)

    Stukalin, Evgeny; Sun, Sean

    2013-03-01

    The probability of cell division per unit time strongly depends of age of cells, i.e., time elapsed since their birth. The theory of cell populations in the age-time representation is systematically applied for modeling cell division for different spreads in generation times. We use stochastic simulations to address the same issue at the level of individual cells. Our approach unlike deterministic theory enables to analyze the size fluctuations of cell colonies at different growth conditions (in the absence and in the presence of cell death, for initially synchronized and asynchronous cell populations, for conditions of restricted growth). We find the simple quantitative relation between the asymptotic values of relative size fluctuations around mean values for initially synchronized cell populations under growth and the coefficients of variation of generation times. Effect of initial age distribution for asynchronous growth of cell cultures is also studied by simulations. The influence of constant cell death on fluctuations of sizes of cell populations is found to be essential even for small cell death rates, i.e., for realistic growth conditions. The stochastic model is generalized for biologically relevant case that involves both cell reproduction and cell differentiation.

  13. Wealth distribution of simple exchange models coupled with extremal dynamics

    Science.gov (United States)

    Bagatella-Flores, N.; Rodríguez-Achach, M.; Coronel-Brizio, H. F.; Hernández-Montoya, A. R.

    2015-01-01

    Punctuated Equilibrium (PE) states that after long periods of evolutionary quiescence, species evolution can take place in short time intervals, where sudden differentiation makes new species emerge and some species extinct. In this paper, we introduce and study the effect of punctuated equilibrium on two different asset exchange models: the yard sale model (YS, winner gets a random fraction of a poorer player's wealth) and the theft and fraud model (TF, winner gets a random fraction of the loser's wealth). The resulting wealth distribution is characterized using the Gini index. In order to do this, we consider PE as a perturbation with probability ρ of being applied. We compare the resulting values of the Gini index at different increasing values of ρ in both models. We found that in the case of the TF model, the Gini index reduces as the perturbation ρ increases, not showing dependence with the agents number. While for YS we observe a phase transition which happens around ρc = 0.79. For perturbations ρ <ρc the Gini index reaches the value of one as time increases (an extreme wealth condensation state), whereas for perturbations greater than or equal to ρc the Gini index becomes different to one, avoiding the system reaches this extreme state. We show that both simple exchange models coupled with PE dynamics give more realistic results. In particular for YS, we observe a power low decay of wealth distribution.

  14. How to Become a Dictator: a Simple Model from Physics

    Science.gov (United States)

    Galam, Serge

    The dynamics of majority rule voting in hierarchical structures is studied using concepts from collective phenomena in physics. In the case of a two-party competition a very simple model to a democratic dictatorship is presented. For each running group, a critical threshold (in the overall support) is found to ensure full and total power at the hierarchy top. However, the respective value of this threshold may vary a lot from one party to the other. It is this difference which creates the dictatorian nature of the democratic voting system. While climbing up the hierarchy, the initial majority-minority ratio can be reversed at the profit of actual running party. Such a reversal is shown to be driven by the natural inertia of being in power. The model could shed light on last century Eastern European Communist collapse.

  15. A simple stationary semi-analytical wake model

    DEFF Research Database (Denmark)

    Larsen, Gunner Chr.

    We present an idealized simple, but fast, semi-analytical algorithm for computation of stationary wind farm wind fields with a possible potential within a multi-fidelity strategy for wind farm topology optimization. Basically, the model considers wakes as linear perturbations on the ambient non...... rotationally symmetric, and the rotor inflow fields are consistently assumed uniform. Expansion of stationary wake fields is believed to be significantly affected by meandering of wake deficits as e.g. described by the Dynamic Wake Meandering model. In the present context, this effect is approximately...... conditions are imposed), the present formulation of wake expansion is believed to underestimate wake expansion, because the analytical wake formulation dictates the wake expansion to behave as x1/3 with downstream distance, whereas wake expansion as primary controlled by wake meandering develops...

  16. From Innovation to Diversification: A Simple Competitive Model.

    Science.gov (United States)

    Saracco, Fabio; Di Clemente, Riccardo; Gabrielli, Andrea; Pietronero, Luciano

    2015-01-01

    Few attempts have been proposed in order to describe the statistical features and historical evolution of the export bipartite matrix countries/products. An important standpoint is the introduction of a products network, namely a hierarchical forest of products that models the formation and the evolution of commodities. In the present article, we propose a simple dynamical model where countries compete with each other to acquire the ability to produce and export new products. Countries will have two possibilities to expand their export: innovating, i.e. introducing new goods, namely new nodes in the product networks, or copying the productive process of others, i.e. occupying a node already present in the same network. In this way, the topology of the products network and the country-product matrix evolve simultaneously, driven by the countries push toward innovation.

  17. Development of simple kinetic models and parameter estimation for ...

    African Journals Online (AJOL)

    In order to describe and predict the growth and expression of recombinant proteins by using a genetically modified Pichia pastoris, we developed a number of unstructured models based on growth kinetic equation, fed-batch mass balance and the assumptions of constant cell and protein yields. The growth of P. pastoris on ...

  18. Simple Brownian diffusion an introduction to the standard theoretical models

    CERN Document Server

    Gillespie, Daniel T

    2013-01-01

    Brownian diffusion, the motion of large molecules in a sea of very many much smaller molecules, is topical because it is one of the ways in which biologically important molecules move about inside living cells. This book presents the mathematical physics that underlies the four simplest models of Brownian diffusion.

  19. Modelling the transition from simple to complex Ca oscillations in ...

    Indian Academy of Sciences (India)

    2014-04-29

    Apr 29, 2014 ... feedback regulation of degradation and production. In our model, the apical and the basal ... transmitters or hormones, pancreatic acinar cells exhibit intracellular calcium oscillations (Tanimura 2009; ...... Putney JW, Broad LM, Braun FJ, Lievremont JP and Bird GH 2001. Mechanisms of capacitative calcium ...

  20. Fire, ice, water, and dirt: A simple climate model.

    Science.gov (United States)

    Kroll, John

    2017-07-01

    A simple paleoclimate model was developed as a modeling exercise. The model is a lumped parameter system consisting of an ocean (water), land (dirt), glacier, and sea ice (ice) and driven by the sun (fire). In comparison with other such models, its uniqueness lies in its relative simplicity yet yielding good results. For nominal values of parameters, the system is very sensitive to small changes in the parameters, yielding equilibrium, steady oscillations, and catastrophes such as freezing or boiling oceans. However, stable solutions can be found, especially naturally oscillating solutions. For nominally realistic conditions, natural periods of order 100kyrs are obtained, and chaos ensues if the Milankovitch orbital forcing is applied. An analysis of a truncated system shows that the naturally oscillating solution is a limit cycle with the characteristics of a relaxation oscillation in the two major dependent variables, the ocean temperature and the glacier ice extent. The key to getting oscillations is having the effective emissivity decreasing with temperature and, at the same time, the effective ocean albedo decreases with increasing glacier extent. Results of the original model compare favorably to the proxy data for ice mass variation, but not for temperature variation. However, modifications to the effective emissivity and albedo can be made to yield much more realistic results. The primary conclusion is that the opinion of Saltzman [Clim. Dyn. 5, 67-78 (1990)] is plausible that the external Milankovitch orbital forcing is not sufficient to explain the dominant 100kyr period in the data.

  1. Simple model for multiple-choice collective decision making.

    Science.gov (United States)

    Lee, Ching Hua; Lucas, Andrew

    2014-11-01

    We describe a simple model of heterogeneous, interacting agents making decisions between n≥2 discrete choices. For a special class of interactions, our model is the mean field description of random field Potts-like models and is effectively solved by finding the extrema of the average energy E per agent. In these cases, by studying the propagation of decision changes via avalanches, we argue that macroscopic dynamics is well captured by a gradient flow along E. We focus on the permutation symmetric case, where all n choices are (on average) the same, and spontaneous symmetry breaking (SSB) arises purely from cooperative social interactions. As examples, we show that bimodal heterogeneity naturally provides a mechanism for the spontaneous formation of hierarchies between decisions and that SSB is a preferred instability to discontinuous phase transitions between two symmetric points. Beyond the mean field limit, exponentially many stable equilibria emerge when we place this model on a graph of finite mean degree. We conclude with speculation on decision making with persistent collective oscillations. Throughout the paper, we emphasize analogies between methods of solution to our model and common intuition from diverse areas of physics, including statistical physics and electromagnetism.

  2. Fire, ice, water, and dirt: A simple climate model

    Science.gov (United States)

    Kroll, John

    2017-07-01

    A simple paleoclimate model was developed as a modeling exercise. The model is a lumped parameter system consisting of an ocean (water), land (dirt), glacier, and sea ice (ice) and driven by the sun (fire). In comparison with other such models, its uniqueness lies in its relative simplicity yet yielding good results. For nominal values of parameters, the system is very sensitive to small changes in the parameters, yielding equilibrium, steady oscillations, and catastrophes such as freezing or boiling oceans. However, stable solutions can be found, especially naturally oscillating solutions. For nominally realistic conditions, natural periods of order 100kyrs are obtained, and chaos ensues if the Milankovitch orbital forcing is applied. An analysis of a truncated system shows that the naturally oscillating solution is a limit cycle with the characteristics of a relaxation oscillation in the two major dependent variables, the ocean temperature and the glacier ice extent. The key to getting oscillations is having the effective emissivity decreasing with temperature and, at the same time, the effective ocean albedo decreases with increasing glacier extent. Results of the original model compare favorably to the proxy data for ice mass variation, but not for temperature variation. However, modifications to the effective emissivity and albedo can be made to yield much more realistic results. The primary conclusion is that the opinion of Saltzman [Clim. Dyn. 5, 67-78 (1990)] is plausible that the external Milankovitch orbital forcing is not sufficient to explain the dominant 100kyr period in the data.

  3. Glycolysis Is Governed by Growth Regime and Simple Enzyme Regulation in Adherent MDCK Cells

    Science.gov (United States)

    Rehberg, Markus; Ritter, Joachim B.; Reichl, Udo

    2014-01-01

    Due to its vital importance in the supply of cellular pathways with energy and precursors, glycolysis has been studied for several decades regarding its capacity and regulation. For a systems-level understanding of the Madin-Darby canine kidney (MDCK) cell metabolism, we couple a segregated cell growth model published earlier with a structured model of glycolysis, which is based on relatively simple kinetics for enzymatic reactions of glycolysis, to explain the pathway dynamics under various cultivation conditions. The structured model takes into account in vitro enzyme activities, and links glycolysis with pentose phosphate pathway and glycogenesis. Using a single parameterization, metabolite pool dynamics during cell cultivation, glucose limitation and glucose pulse experiments can be consistently reproduced by considering the cultivation history of the cells. Growth phase-dependent glucose uptake together with cell-specific volume changes generate high intracellular metabolite pools and flux rates to satisfy the cellular demand during growth. Under glucose limitation, the coordinated control of glycolytic enzymes re-adjusts the glycolytic flux to prevent the depletion of glycolytic intermediates. Finally, the model's predictive power supports the design of more efficient bioprocesses. PMID:25329309

  4. Simple models for studying complex spatiotemporal patterns of animal behavior

    Science.gov (United States)

    Tyutyunov, Yuri V.; Titova, Lyudmila I.

    2017-06-01

    Minimal mathematical models able to explain complex patterns of animal behavior are essential parts of simulation systems describing large-scale spatiotemporal dynamics of trophic communities, particularly those with wide-ranging species, such as occur in pelagic environments. We present results obtained with three different modelling approaches: (i) an individual-based model of animal spatial behavior; (ii) a continuous taxis-diffusion-reaction system of partial-difference equations; (iii) a 'hybrid' approach combining the individual-based algorithm of organism movements with explicit description of decay and diffusion of the movement stimuli. Though the models are based on extremely simple rules, they all allow description of spatial movements of animals in a predator-prey system within a closed habitat, reproducing some typical patterns of the pursuit-evasion behavior observed in natural populations. In all three models, at each spatial position the animal movements are determined by local conditions only, so the pattern of collective behavior emerges due to self-organization. The movement velocities of animals are proportional to the density gradients of specific cues emitted by individuals of the antagonistic species (pheromones, exometabolites or mechanical waves of the media, e.g., sound). These cues play a role of taxis stimuli: prey attract predators, while predators repel prey. Depending on the nature and the properties of the movement stimulus we propose using either a simplified individual-based model, a continuous taxis pursuit-evasion system, or a little more detailed 'hybrid' approach that combines simulation of the individual movements with the continuous model describing diffusion and decay of the stimuli in an explicit way. These can be used to improve movement models for many species, including large marine predators.

  5. Simple display system of mechanical properties of cells and their dispersion.

    Directory of Open Access Journals (Sweden)

    Yuji Shimizu

    Full Text Available The mechanical properties of cells are unique indicators of their states and functions. Though, it is difficult to recognize the degrees of mechanical properties, due to small size of the cell and broad distribution of the mechanical properties. Here, we developed a simple virtual reality system for presenting the mechanical properties of cells and their dispersion using a haptic device and a PC. This system simulates atomic force microscopy (AFM nanoindentation experiments for floating cells in virtual environments. An operator can virtually position the AFM spherical probe over a round cell with the haptic handle on the PC monitor and feel the force interaction. The Young's modulus of mesenchymal stem cells and HEK293 cells in the floating state was measured by AFM. The distribution of the Young's modulus of these cells was broad, and the distribution complied with a log-normal pattern. To represent the mechanical properties together with the cell variance, we used log-normal distribution-dependent random number determined by the mode and variance values of the Young's modulus of these cells. The represented Young's modulus was determined for each touching event of the probe surface and the cell object, and the haptic device-generating force was calculated using a Hertz model corresponding to the indentation depth and the fixed Young's modulus value. Using this system, we can feel the mechanical properties and their dispersion in each cell type in real time. This system will help us not only recognize the degrees of mechanical properties of diverse cells but also share them with others.

  6. Wind Power Curve Modeling in Simple and Complex Terrain

    Energy Technology Data Exchange (ETDEWEB)

    Bulaevskaya, V. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wharton, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Irons, Z. [Enel Green Power North America, Andover, MA (United States); Qualley, G. [Pentalum, Colleyville, TX (United States)

    2015-02-09

    Our previous work on wind power curve modeling using statistical models focused on a location with a moderately complex terrain in the Altamont Pass region in northern California (CA). The work described here is the follow-up to that work, but at a location with a simple terrain in northern Oklahoma (OK). The goal of the present analysis was to determine the gain in predictive ability afforded by adding information beyond the hub-height wind speed, such as wind speeds at other heights, as well as other atmospheric variables, to the power prediction model at this new location and compare the results to those obtained at the CA site in the previous study. While we reach some of the same conclusions at both sites, many results reported for the CA site do not hold at the OK site. In particular, using the entire vertical profile of wind speeds improves the accuracy of wind power prediction relative to using the hub-height wind speed alone at both sites. However, in contrast to the CA site, the rotor equivalent wind speed (REWS) performs almost as well as the entire profile at the OK site. Another difference is that at the CA site, adding wind veer as a predictor significantly improved the power prediction accuracy. The same was true for that site when air density was added to the model separately instead of using the standard air density adjustment. At the OK site, these additional variables result in no significant benefit for the prediction accuracy.

  7. Analysis of ductile crack growth by a simple damage model

    International Nuclear Information System (INIS)

    Zhang, Ch.; Gross, D.

    1993-01-01

    A strip damage-zone model of the Dugdale-Barenblatt-model type is presented in this paper for analyzing crack growth in ductile materials with damage evolution. In particular, a semi-infinite Mode-1 crack in plane stress or plane strain is considered. The damage is assumed to be present in form of dispersed microvoids, which are localized into a narrow strip direct ahead of a crack-tip. This configuration approximates the real situation naturally arising due to the high stress and strain concentrations in the proximity of the crack-tip. A simple damage model of the Gurson-model type is developed for uniaxial tension to describe the macroscopic properties of the strip damage-zone. Under small-scale yielding and small-scale damage conditions, a system of nonlinear integral equations for the plastic strain and the length of the damage-zone is derived. Numerical results are presented and discussed for the crack opening displacement, the stress and damage distribution within the plastic/damage zone, and the crack resistance curve. Special attention is devoted to reveal the effect of damage evolution on the ductile crack growth

  8. Phase Diagram of a Simple Model for Fractional Topological Insulator

    Science.gov (United States)

    Chen, Hua; Yang, Kun

    2012-02-01

    We study a simple model of two species of (or spin-1/2) fermions with short-range intra-species repulsion in the presence of opposite (effetive) magnetic field, each at filling factor 1/3. In the absence of inter-species interaction, the ground state is simply two copies of the 1/3 Laughlin state, with opposite chirality. Due to the overall time-reversal symmetry, this is a fractional topological insulator. We show this phase is stable against moderate inter-species interactions. However strong enough inter-species repulsion leads to phase separation, while strong enough inter-species attraction drives the system into a superfluid phase. We obtain the phase diagram through exact diagonalization caluclations. Nature of the fractional topological insluator-superfluid phase transition is discussed using an appropriate Chern-Simons-Ginsburg-Landau effective field theory.

  9. Behaviour of ion velocity distributions for a simple collision model

    Science.gov (United States)

    St-Maurice, J.-P.; Schunk, R. W.

    1974-01-01

    Calculation of the ion velocity distributions for a weakly ionized plasma subjected to crossed electric and magnetic fields. An exact solution to Boltzmann's equation has been obtained by replacing the Boltzmann collision integral with a simple relaxation model. At altitudes above about 150 km, where the ion collision frequency is much less than the ion cyclotron frequency, the ion distribution takes the shape of a torus in velocity space for electric fields greater than 40 mV/m. This shape persists for one to two hours after application of the electric field. At altitudes where the ion collision and cyclotron frequencies are approximately equal (about 120 km), the ion velocity distribution is shaped like a bean for large electric field strengths. This bean-shaped distribution persists throughout the lifetime of ionospheric electric fields. These highly non-Maxwellian ion velocity distributions may have an appreciable affect on the interpretation of ion temperature measurements.

  10. Teaching scientific concepts through simple models and social communication techniques

    International Nuclear Information System (INIS)

    Tilakaratne, K.

    2011-01-01

    For science education, it is important to demonstrate to students the relevance of scientific concepts in every-day life experiences. Although there are methods available for achieving this goal, it is more effective if cultural flavor is also added to the teaching techniques and thereby the teacher and students can easily relate the subject matter to their surroundings. Furthermore, this would bridge the gap between science and day-to-day experiences in an effective manner. It could also help students to use science as a tool to solve problems faced by them and consequently they would feel science is a part of their lives. In this paper, it has been described how simple models and cultural communication techniques can be used effectively in demonstrating important scientific concepts to the students of secondary and higher secondary levels by using two consecutive activities carried out at the Institute of Fundamental Studies (IFS), Sri Lanka. (author)

  11. A SIMPLE EXPERIMENTAL MODEL OF HEAT SHOCK RESPONSE IN RATS

    Directory of Open Access Journals (Sweden)

    Tufi Neder Meyer

    1998-10-01

    Full Text Available Objective: To obtain a simple model for the elicitation of the heat shock response in rats. Design: Laboratory study. Setting: University research laboratories. Sample: Seventy-nine adult male albino rats (weight range 200 g to 570 g. Procedures: Exposure to heat stress by heating animals in a warm bath for 5 min after their rectal temperatures reached 107.60 F (420 C. Liver and lung samples were collected for heat-shock protein 70 (HSP70 detection (Western analysis. Results: Western analysis was positive for HSP70 in the liver and in the lungs of heated animals. There was a temporal correlation between heating and HSP70 detection: it was strongest 1 day after heating and reduced afterwards. No heated animals died. Conclusion: These data show that heating rats in a warm (45o C bath, according to parameters set in this model, elicits efficiently the heat shock response.OBJETIVO: Obter um modelo simples para tentar esclarecer a resposta ao choque térmico em ratos. LOCAL: Laboratório de pesquisa da Universidade. MÉTODO: Amostra: 79 ratos albinos, adultos, entre 200g a 570g. Procedimentos: Exposição ao calor, em banho quente, por 5 minutos, após a temperatura retal chegar a 42 graus centigrados. Biópsias de fígado e pulmão foram obtidas para detectar a proteina 70 (HSP 70, pelo "Western blot". RESULTADOS: As análises foram positivas nos animais aquecidos, com uma correlação entre aquecimento e constatação da HSP 70. Foi mais elevada no primeiro dia e não houve óbitos nos animais aquecidos. CONCLUSÃO: Os ratos aquecidos a 45 graus centígrados respondem eficientemente ao choque térmico.

  12. A simple physical model predicts small exon length variations.

    Directory of Open Access Journals (Sweden)

    2006-04-01

    Full Text Available One of the most common splice variations are small exon length variations caused by the use of alternative donor or acceptor splice sites that are in very close proximity on the pre-mRNA. Among these, three-nucleotide variations at so-called NAGNAG tandem acceptor sites have recently attracted considerable attention, and it has been suggested that these variations are regulated and serve to fine-tune protein forms by the addition or removal of a single amino acid. In this paper we first show that in-frame exon length variations are generally overrepresented and that this overrepresentation can be quantitatively explained by the effect of nonsense-mediated decay. Our analysis allows us to estimate that about 50% of frame-shifted coding transcripts are targeted by nonsense-mediated decay. Second, we show that a simple physical model that assumes that the splicing machinery stochastically binds to nearby splice sites in proportion to the affinities of the sites correctly predicts the relative abundances of different small length variations at both boundaries. Finally, using the same simple physical model, we show that for NAGNAG sites, the difference in affinities of the neighboring sites for the splicing machinery accurately predicts whether splicing will occur only at the first site, splicing will occur only at the second site, or three-nucleotide splice variants are likely to occur. Our analysis thus suggests that small exon length variations are the result of stochastic binding of the spliceosome at neighboring splice sites. Small exon length variations occur when there are nearby alternative splice sites that have similar affinity for the splicing machinery.

  13. A NEW SIMPLE DYNAMO MODEL FOR STELLAR ACTIVITY CYCLE

    Energy Technology Data Exchange (ETDEWEB)

    Yokoi, N.; Hamba, F. [Institute of Industrial Science, University of Tokyo, Tokyo 153-8505 (Japan); Schmitt, D. [Max-Planck Institut für Sonnensystemforschung, Göttingen D-37077 (Germany); Pipin, V., E-mail: nobyokoi@iis.u-tokyo.ac.jp [Institute of Solar–Terrestrial Physics, Russian Academy of Science, Irkutsk 664033 (Russian Federation)

    2016-06-20

    A new simple dynamo model for stellar activity cycle is proposed. By considering an inhomogeneous flow effect on turbulence, it is shown that turbulent cross helicity (velocity–magnetic-field correlation) enters the expression of turbulent electromotive force as the coupling coefficient for the mean absolute vorticity. This makes the present model different from the current α –Ω-type models in two main ways. First, in addition to the usual helicity ( α ) and turbulent magnetic diffusivity ( β ) effects, we consider the cross-helicity effect as a key ingredient of the dynamo process. Second, the spatiotemporal evolution of cross helicity is solved simultaneously with the mean magnetic fields. The basic scenario is as follows. In the presence of turbulent cross helicity, the toroidal field is induced by the toroidal rotation. Then, as in usual models, the α effect generates the poloidal field from the toroidal one. This induced poloidal field produces a turbulent cross helicity whose sign is opposite to the original one (negative production). With this cross helicity of the reversed sign, a reversal in field configuration starts. Eigenvalue analyses of the simplest possible model give a butterfly diagram, which confirms the above scenario and the equatorward migrations, the phase relationship between the cross helicity and magnetic fields. These results suggest that the oscillation of the turbulent cross helicity is a key for the activity cycle. The reversal of the cross helicity is not the result of the magnetic-field reversal, but the cause of the latter. This new model is expected to open up the possibility of the mean-field or turbulence closure dynamo approaches.

  14. Simple cosmological model with inflation and late times acceleration

    Science.gov (United States)

    Szydłowski, Marek; Stachowski, Aleksander

    2018-03-01

    In the framework of polynomial Palatini cosmology, we investigate a simple cosmological homogeneous and isotropic model with matter in the Einstein frame. We show that in this model during cosmic evolution, early inflation appears and the accelerating phase of the expansion for the late times. In this frame we obtain the Friedmann equation with matter and dark energy in the form of a scalar field with a potential whose form is determined in a covariant way by the Ricci scalar of the FRW metric. The energy density of matter and dark energy are also parameterized through the Ricci scalar. Early inflation is obtained only for an infinitesimally small fraction of energy density of matter. Between the matter and dark energy, there exists an interaction because the dark energy is decaying. For the characterization of inflation we calculate the slow roll parameters and the constant roll parameter in terms of the Ricci scalar. We have found a characteristic behavior of the time dependence of density of dark energy on the cosmic time following the logistic-like curve which interpolates two almost constant value phases. From the required numbers of N-folds we have found a bound on the model parameter.

  15. Complex Coronary Hemodynamics - Simple Analog Modelling as an Educational Tool.

    Science.gov (United States)

    Parikh, Gaurav R; Peter, Elvis; Kakouros, Nikolaos

    2017-01-01

    Invasive coronary angiography remains the cornerstone for evaluation of coronary stenoses despite there being a poor correlation between luminal loss assessment by coronary luminography and myocardial ischemia. This is especially true for coronary lesions deemed moderate by visual assessment. Coronary pressure-derived fractional flow reserve (FFR) has emerged as the gold standard for the evaluation of hemodynamic significance of coronary artery stenosis, which is cost effective and leads to improved patient outcomes. There are, however, several limitations to the use of FFR including the evaluation of serial stenoses. In this article, we discuss the electronic-hydraulic analogy and the utility of simple electrical modelling to mimic the coronary circulation and coronary stenoses. We exemplify the effect of tandem coronary lesions on the FFR by modelling of a patient with sequential disease segments and complex anatomy. We believe that such computational modelling can serve as a powerful educational tool to help clinicians better understand the complexity of coronary hemodynamics and improve patient care.

  16. Simple Electromagnetic Modeling of Small Airplanes: Neural Network Approach

    Directory of Open Access Journals (Sweden)

    P. Tobola

    2009-04-01

    Full Text Available The paper deals with the development of simple electromagnetic models of small airplanes, which can contain composite materials in their construction. Electromagnetic waves can penetrate through the surface of the aircraft due to the specific electromagnetic properties of the composite materials, which can increase the intensity of fields inside the airplane and can negatively influence the functionality of the sensitive avionics. The airplane is simulated by two parallel dielectric layers (the left-hand side wall and the right-hand side wall of the airplane. The layers are put into a rectangular metallic waveguide terminated by the absorber in order to simulate the illumination of the airplane by the external wave (both of the harmonic nature and pulse one. Thanks to the simplicity of the model, the parametric analysis can be performed, and the results can be used in order to train an artificial neural network. The trained networks excel in further reduction of CPU-time demands of an airplane modeling.

  17. Simple analytical model of evapotranspiration in the presence of roots.

    Science.gov (United States)

    Cejas, Cesare M; Hough, L A; Castaing, Jean-Christophe; Frétigny, Christian; Dreyfus, Rémi

    2014-10-01

    Evaporation of water out of a soil involves complicated and well-debated mechanisms. When plant roots are added into the soil, water transfer between the soil and the outside environment is even more complicated. Indeed, plants provide an additional process of water transfer. Water is pumped by the roots, channeled to the leaf surface, and released into the surrounding air by a process called transpiration. Prediction of the evapotranspiration of water over time in the presence of roots helps keep track of the amount of water that remains in the soil. Using a controlled visual setup of a two-dimensional model soil consisting of monodisperse glass beads, we perform experiments on actual roots grown under different relative humidity conditions. We record the total water mass loss in the medium and the position of the evaporating front that forms within the medium. We then develop a simple analytical model that predicts the position of the evaporating front as a function of time as well as the total amount of water that is lost from the medium due to the combined effects of evaporation and transpiration. The model is based on fundamental principles of evaporation fluxes and includes empirical assumptions on the quantity of open stomata in the leaves, where water transpiration occurs. Comparison between the model and experimental results shows excellent prediction of the position of the evaporating front as well as the total mass loss from evapotranspiration in the presence of roots. The model also provides a way to predict the lifetime of a plant.

  18. A simple method to eliminate mycoplasma from cell cultures.

    Science.gov (United States)

    Coronato, S; Vullo, D; Coto, C E

    1994-01-01

    The efficacy of several antibiotic treatments to eliminate mycoplasma from Vero cells contaminated chronically with Mycoplasma orale II were tested. Minocyclin, Kanamycin, Tylosine and Roxitromycin, at non cytotoxic concentrations, were assayed alone or in different combinations. Mycoplasma contamination was effectively eradicated without recurrence once the following regimen was applied: Incubation of contaminated cells with Tylosine (250 micrograms/ml) for 12 days followed by incubation with Minocycline (5 micrograms/ml) for 10 days. This treatment was not deleterious for cell growth, it was effective after only one application and it was successful to eradicate mycoplasma from other contaminated eukaryotic continuous cell lines.

  19. Simple processing of high efficiency silicon solar cells

    International Nuclear Information System (INIS)

    Hamammu, I.M.; Ibrahim, K.

    2006-01-01

    Cost effective photovoltaic devices have been an area research since the development of the first solar cells, as cost is the major factor in their usage. Silicon solar cells have the biggest share in the photovoltaic market, though silicon os not the optimal material for solar cells. This work introduces a simplified approach for high efficiency silicon solar cell processing, by minimizing the processing steps and thereby reducing cost. The suggested procedure might also allow for the usage of lower quality materials compared to the one used today. The main features of the present work fall into: simplifying the diffusion process, edge shunt isolation and using acidic texturing instead of the standard alkaline processing. Solar cells of 17% efficiency have been produced using this procedure. Investigations on the possibility of improving the efficiency and using less quality material are still underway

  20. A simple model for research interest evolution patterns

    Science.gov (United States)

    Jia, Tao; Wang, Dashun; Szymanski, Boleslaw

    Sir Isaac Newton supposedly remarked that in his scientific career he was like ``...a boy playing on the sea-shore ...finding a smoother pebble or a prettier shell than ordinary''. His remarkable modesty and famous understatement motivate us to seek regularities in how scientists shift their research focus as the career develops. Indeed, despite intensive investigations on how microscopic factors, such as incentives and risks, would influence a scientist's choice of research agenda, little is known on the macroscopic patterns in the research interest change undertaken by individual scientists throughout their careers. Here we make use of over 14,000 authors' publication records in physics. By quantifying statistical characteristics in the interest evolution, we model scientific research as a random walk, which reproduces patterns in individuals' careers observed empirically. Despite myriad of factors that shape and influence individual choices of research subjects, we identified regularities in this dynamical process that are well captured by a simple statistical model. The results advance our understanding of scientists' behaviors during their careers and open up avenues for future studies in the science of science.

  1. Simple Photovoltaic Cells for Exploring Solar Energy Concepts

    Science.gov (United States)

    Appleyard, S. J.

    2006-01-01

    Low-efficiency solar cells for educational purposes can be simply made in school or home environments using wet-chemistry techniques and readily available chemicals of generally low toxicity. Instructions are given for making solar cells based on the heterojunctions Cu/Cu[subscript 2]O, Cu[subscript 2]O/ZnO and Cu[subscript 2]S/ZnO, together with…

  2. Simple integer recourse models : convexity and convex approximations

    NARCIS (Netherlands)

    Klein Haneveld, W.K.; Stougie, L.; van der Vlerk, M.H.

    We consider the objective function of a simple recourse problem with fixed technology matrix and integer second-stage variables. Separability due to the simple recourse structure allows to study a one-dimensional version instead. Based on an explicit formula for the objective function, we derive a

  3. Simple Integer Recourse Models : Convexity and Convex Approximations

    NARCIS (Netherlands)

    Klein Haneveld, Willem K.; Stougie, L; van der Vlerk, Maarten H.

    2004-01-01

    We consider the objective function of a simple recourse problem with fixed technology matrix and integer second-stage variables. Separability due to the simple recourse structure allows to study a one-dimensional version instead. Based on an explicit formula for the objective function, we derive a

  4. Simple models of two-dimensional information sources and codes

    DEFF Research Database (Denmark)

    Justesen, Jørn; Shtarkov, Y. M.

    1998-01-01

    We consider discrete random fields which have simple descriptions of rows and columns. We present constructions which combine high entropy with simple means of generating the fields and analyzing the probability distribution. Hidden state Markov sources are an essential tool in the construction...

  5. Changes in Purkinje Cell Simple Spike Encoding of Reach Kinematics during Adaption to a Mechanical Perturbation

    Science.gov (United States)

    Hewitt, Angela L.; Popa, Laurentiu S.

    2015-01-01

    The cerebellum is essential in motor learning. At the cellular level, changes occur in both the simple spike and complex spike firing of Purkinje cells. Because simple spike discharge reflects the main output of the cerebellar cortex, changes in simple spike firing likely reflect the contribution of the cerebellum to the adapted behavior. Therefore, we investigated in Rhesus monkeys how the representation of arm kinematics in Purkinje cell simple spike discharge changed during adaptation to mechanical perturbations of reach movements. Monkeys rapidly adapted to a novel assistive or resistive perturbation along the direction of the reach. Adaptation consisted of matching the amplitude and timing of the perturbation to minimize its effect on the reach. In a majority of Purkinje cells, simple spike firing recorded before and during adaptation demonstrated significant changes in position, velocity, and acceleration sensitivity. The timing of the simple spike representations change within individual cells, including shifts in predictive versus feedback signals. At the population level, feedback-based encoding of position increases early in learning and velocity decreases. Both timing changes reverse later in learning. The complex spike discharge was only weakly modulated by the perturbations, demonstrating that the changes in simple spike firing can be independent of climbing fiber input. In summary, we observed extensive alterations in individual Purkinje cell encoding of reach kinematics, although the movements were nearly identical in the baseline and adapted states. Therefore, adaption to mechanical perturbation of a reaching movement is accompanied by widespread modifications in the simple spike encoding. PMID:25609626

  6. A simple model to predict soil moisture: Bridging Event and Continuous Hydrological (BEACH) modelling

    NARCIS (Netherlands)

    Sheikh, V.; Visser, S.M.; Stroosnijder, L.

    2009-01-01

    This paper introduces a simple two-layer soil water balance model developed to Bridge Event And Continuous Hydrological (BEACH) modelling. BEACH is a spatially distributed daily basis hydrological model formulated to predict the initial condition of soil moisture for event-based soil erosion and

  7. Modelling the influence of yaw using a simple vortex rotor model

    DEFF Research Database (Denmark)

    Troldborg, Niels; Gaunaa, Mac; Guntur, Srinivas

    2012-01-01

    A simple analytical rotor model based on vortex theory is briefly presented and used to investigate the main mechanisms for wind turbine rotors operating at yaw misalignment. The overall findings of the model is verified by comparing with an existing model as well as with results obtained using...

  8. A simple method for unbiased quantitation of adoptively transferred cells in solid tissues

    DEFF Research Database (Denmark)

    Petersen, Mikkel; Petersen, Charlotte Christie; Agger, Ralf

    2006-01-01

    node at six different time points following adoptive transfer (from 60 s to 1 week), providing a quantitative estimate of the organ distribution of the transferred cells over time. These estimates were obtained by microscopy of uniform samples of thick sections from the respective organs. Importantly......, the samples were chosen and prepared in accordance with the optical fractionator principle. We demonstrate that the method is simple, precise, and well suited for quantitative immunological studies.......In a mouse model, we demonstrate how to obtain a direct, unbiased estimate of the total number of adoptively transferred cells in a variety of organs at different time points. The estimate is obtained by a straightforward method based on the optical fractionator principle. Specifically, non...

  9. Noise-Optimized Speciation in a Simple Evolutionary Model

    Science.gov (United States)

    Dees, Nathan; Bahar, Sonya

    2009-03-01

    A simple computational model for Darwinian evolution is constructed based on three minimal requirements: inheritance, variability, and overpopulation. The fitness of organisms is based on their position in a two-dimensional fitness landscape which is changed periodically either by random fluctuations, or via a feedback mechanism based on the number of organisms in close proximity. The clustering of organisms in a morphospace overlaid on this landscape is considered an analog of speciation and is investigated as a function of the degree of variability, or ``noise'', allowed in the morphology of new (children) organisms with respect to their parents. We find that a maximum number of species are formed at an intermediate value of this noise parameter, suggesting a stochastic resonance-like effect. We also address the spread of inherited traits through the overall population, finding an ``all or none'' effect in which the properties of a traced organism either die out completely or percolate through the entire population, leading to what might be considered as ``homologous'' traits even in species widely separated in morphospace.

  10. A simple model of hose instabilities in rotating electron beams

    International Nuclear Information System (INIS)

    Brandenburg, J.E.

    1983-01-01

    A simple foilless diode with a properly designed transmission line feed can generate an intense, wellcollimated annular electron beam. As part of the AID project at Los Alamos, a 3-MeV annular beam is routinely generated with a radius of 1 cm, a thickness of about 100 μ, a current density of about 1 MA/cm 2 , and a scattering angle of about 30 mrad. The particle-in-cell code CEMIT has been used previously to investigate the properties of foilless diodes. It is found that the beam quality can vary significantly during this transition. The best quality beam is achieved by a configuration that is not foilless or foil, but a combination. Microwave generation within the diode and zero-frequency cyclotron wave growth appear to be the major source of energy spread and angular scatter on the beam. Changes in the cathode shape that do not alter the current density profile greatly can change change the energy spread significantly due to microwave generation. Simulations have typically been carried out using a short rise time on the voltage pulse and then holding the voltage constant to obtain a steady state result. When driven by a real source, however, the voltage is continually changing on a time scale that is slow compared with the transit time of the speed of light across the diode. Simulations in which the voltage changes continually have been carried out for both inner and outer conductor foilless diodes. It is found that energy spread dominates the beam at low voltage while angular scatter dominates at higher voltage. Based upon these simulations, a more complete time history of this class of diode is possible

  11. A simple optical fiber device for quantitative fluorescence microscopy of single living cells

    NARCIS (Netherlands)

    van Graft, M.; van Graft, Marja; Oosterhuis, B.; Oosterhuis, Bernard; van der Werf, Kees; de Grooth, B.G.; Greve, Jan

    1993-01-01

    simple and relatively inexpensive system is described for obtaining quantitative fluorescence measurements on single living cells loaded with a fluorescent probe to study cell physiological processes. The light emitted from the fluorescent cells is captured by and transported through an optical

  12. Statistical behaviour of adaptive multilevel splitting algorithms in simple models

    International Nuclear Information System (INIS)

    Rolland, Joran; Simonnet, Eric

    2015-01-01

    Adaptive multilevel splitting algorithms have been introduced rather recently for estimating tail distributions in a fast and efficient way. In particular, they can be used for computing the so-called reactive trajectories corresponding to direct transitions from one metastable state to another. The algorithm is based on successive selection–mutation steps performed on the system in a controlled way. It has two intrinsic parameters, the number of particles/trajectories and the reaction coordinate used for discriminating good or bad trajectories. We investigate first the convergence in law of the algorithm as a function of the timestep for several simple stochastic models. Second, we consider the average duration of reactive trajectories for which no theoretical predictions exist. The most important aspect of this work concerns some systems with two degrees of freedom. They are studied in detail as a function of the reaction coordinate in the asymptotic regime where the number of trajectories goes to infinity. We show that during phase transitions, the statistics of the algorithm deviate significatively from known theoretical results when using non-optimal reaction coordinates. In this case, the variance of the algorithm is peaking at the transition and the convergence of the algorithm can be much slower than the usual expected central limit behaviour. The duration of trajectories is affected as well. Moreover, reactive trajectories do not correspond to the most probable ones. Such behaviour disappears when using the optimal reaction coordinate called committor as predicted by the theory. We finally investigate a three-state Markov chain which reproduces this phenomenon and show logarithmic convergence of the trajectory durations

  13. A simple model for the nuclear unintegrated gluon distribution

    Energy Technology Data Exchange (ETDEWEB)

    Betemps, Marcos Andre [Universidade Federal de Pelotas (UFPel), RS (Brazil). Conjunto Agrotecnico Visconde da Graca; Machado, Magno Valerio Trindade [UNIPAMPA - Universidade Federal do Pampa, Bage, RS (Brazil). Centro de Ciencias Exatas e Tecnologicas

    2009-07-01

    Full text. The knowledge of the QCD dynamics at high energies is essential in understanding the hadronic interactions studied at current (HERA, Tevatron) and future (LHC) accelerators. In the physics of saturation the relevant observable is the forward scattering amplitude of a quark-antiquark dipole on a target. It enters several processes at high energy like deep inelastic scattering (DIS), photoproduction and hadron-hadron scattering. Its quantum evolution has recently been the object of many studies. The Balitsky-Kovchegov (BK) equation valid in the large N{sub c} limit and in the mean field approximation provides a tool to study the rapidity behavior of the gluon distribution in a large momentum range including the saturation region where the effects of gluon recombination, taken into account in the non-linear term, become important. The main features of analytical solutions of BK have been used to parametrize the unintegrated gluon distribution, {phi}(k; Y ), which is the Fourier-transform of dipole-target amplitude. The knowledge of the corresponding nuclear unintegrated gluon distribution is indeed crucial. It is the basic object required to calculate physical observables in the k{sub T} factorized picture employed by the gluon saturation models. The solution of non-linear evolution equations for dense nuclear gluon density has been suggested as one of the relevant mechanisms of pA and AA collisions at collider energies. Here we study a simple parameterization for the unintegrated gluon distribution using the knowledge of asymptotic solutions of the Balitsky-Kovchegov equation, describing high-energy QCD in the presence of saturation effects. A satisfactory description of nuclear shadowing at small-x is obtained and it allows us to understand the qualitative behavior shown by data. (author)

  14. Maintenance of algal endosymbionts in Paramecium bursaria: a simple model based on population dynamics.

    Science.gov (United States)

    Iwai, Sosuke; Fujiwara, Kenji; Tamura, Takuro

    2016-09-01

    Algal endosymbiosis is widely distributed in eukaryotes including many protists and metazoans, and plays important roles in aquatic ecosystems, combining phagotrophy and phototrophy. To maintain a stable symbiotic relationship, endosymbiont population size in the host must be properly regulated and maintained at a constant level; however, the mechanisms underlying the maintenance of algal endosymbionts are still largely unknown. Here we investigate the population dynamics of the unicellular ciliate Paramecium bursaria and its Chlorella-like algal endosymbiont under various experimental conditions in a simple culture system. Our results suggest that endosymbiont population size in P. bursaria was not regulated by active processes such as cell division coupling between the two organisms, or partitioning of the endosymbionts at host cell division. Regardless, endosymbiont population size was eventually adjusted to a nearly constant level once cells were grown with light and nutrients. To explain this apparent regulation of population size, we propose a simple mechanism based on the different growth properties (specifically the nutrient requirements) of the two organisms, and based from this develop a mathematical model to describe the population dynamics of host and endosymbiont. The proposed mechanism and model may provide a basis for understanding the maintenance of algal endosymbionts. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd.

  15. Spike correlations in a songbird agree with a simple markov population model.

    Directory of Open Access Journals (Sweden)

    Andrea P Weber

    2007-12-01

    Full Text Available The relationships between neural activity at the single-cell and the population levels are of central importance for understanding neural codes. In many sensory systems, collective behaviors in large cell groups can be described by pairwise spike correlations. Here, we test whether in a highly specialized premotor system of songbirds, pairwise spike correlations themselves can be seen as a simple corollary of an underlying random process. We test hypotheses on connectivity and network dynamics in the motor pathway of zebra finches using a high-level population model that is independent of detailed single-neuron properties. We assume that neural population activity evolves along a finite set of states during singing, and that during sleep population activity randomly switches back and forth between song states and a single resting state. Individual spike trains are generated by associating with each of the population states a particular firing mode, such as bursting or tonic firing. With an overall modification of one or two simple control parameters, the Markov model is able to reproduce observed firing statistics and spike correlations in different neuron types and behavioral states. Our results suggest that song- and sleep-related firing patterns are identical on short time scales and result from random sampling of a unique underlying theme. The efficiency of our population model may apply also to other neural systems in which population hypotheses can be tested on recordings from small neuron groups.

  16. Simple models for the simulation of submarine melt for a Greenland glacial system model

    Science.gov (United States)

    Beckmann, Johanna; Perrette, Mahé; Ganopolski, Andrey

    2018-01-01

    Two hundred marine-terminating Greenland outlet glaciers deliver more than half of the annually accumulated ice into the ocean and have played an important role in the Greenland ice sheet mass loss observed since the mid-1990s. Submarine melt may play a crucial role in the mass balance and position of the grounding line of these outlet glaciers. As the ocean warms, it is expected that submarine melt will increase, potentially driving outlet glaciers retreat and contributing to sea level rise. Projections of the future contribution of outlet glaciers to sea level rise are hampered by the necessity to use models with extremely high resolution of the order of a few hundred meters. That requirement in not only demanded when modeling outlet glaciers as a stand alone model but also when coupling them with high-resolution 3-D ocean models. In addition, fjord bathymetry data are mostly missing or inaccurate (errors of several hundreds of meters), which questions the benefit of using computationally expensive 3-D models for future predictions. Here we propose an alternative approach built on the use of a computationally efficient simple model of submarine melt based on turbulent plume theory. We show that such a simple model is in reasonable agreement with several available modeling studies. We performed a suite of experiments to analyze sensitivity of these simple models to model parameters and climate characteristics. We found that the computationally cheap plume model demonstrates qualitatively similar behavior as 3-D general circulation models. To match results of the 3-D models in a quantitative manner, a scaling factor of the order of 1 is needed for the plume models. We applied this approach to model submarine melt for six representative Greenland glaciers and found that the application of a line plume can produce submarine melt compatible with observational data. Our results show that the line plume model is more appropriate than the cone plume model for simulating

  17. using explanatory models to derive simple tools for Avanced Life Support system studies - Crop Modelling

    Science.gov (United States)

    Cavazzoni, J.

    System-level analyses for Advanced Life Support (ALS) require mathematical models for various processes, such as biomass production and waste management, which would ideally be integrated into overall system models. Explanatory models (also referred to as mechanistic or process models) would provide the basis for a more robust system model, as these would be based on an understanding of processes specific to ALS studies. However, integrating such models may not always be practicable because of their complexity, especially for initial system-level analyses where simple sub-models may be satisfactory. One way to address this is to capture important features of explanatory models in simple models that may be readily integrated for system-level analyses. In this paper, explanatory crop models were used to generate parameters and multi-variable polynomial equations for basic models that are suitable for estimating the direction and magnitude of daily changes in canopy gas-exchange, harvest index, and production scheduling due to off- nominal conditions for ALS system studies. The simplest variant of these models consists of only a few equations, and has been integrated into a top-level SIMULINK model for the Bioregenerative Planetary Life Support Systems Test Complex (BIO-Plex), a large-scale human-rated test facility under development at NASA Johnson Space Center. When included in systems studies, the simple crop models may help identify issues that need to be addressed using more detailed modeling studies and specific experiments. Similar modeling simplifications may also prove useful for other ALS sub-systems, as well as for Earth system applications.

  18. Buckling Instabilities and Complex Trajectories in a Simple Model of Uniflagellar Bacteria.

    Science.gov (United States)

    Nguyen, Frank T M; Graham, Michael D

    2017-03-14

    Observations of uniflagellar bacteria show that buckling instabilities of the hook protein connecting the cell body and flagellum play a role in locomotion. To understand this phenomenon, we develop models at varying levels of description with a particular focus on the parameter dependence of the buckling instability. A key dimensionless group called the flexibility number measures the hook flexibility relative to the thrust exerted by the flagellum; this parameter and the geometric parameters of the cell determine the stability of straight swimming. Two very simple models amenable to analytical treatment are developed to examine buckling in stationary (pinned) and moving swimmers. We then consider a more detailed model incorporating a helical flagellum and the rotational degrees of freedom of the cell body and flagellum, and we use numerical simulations to map out the parameter dependence of the buckling instability. In all models, a bifurcation occurs as the flexibility number increases, separating equilibrium configurations into straight or bent, and for the full model, separating trajectories into straight or helical. More specifically for the latter, the critical flexibility marks the transition from periodicity to quasi-periodicity in the behavior of variables determining configuration. We also find that for a given body geometry, there is a specific flagellar geometry that minimizes the critical flexibility number at which buckling occurs. These results highlight the role of flexibility in the biology of real organisms and the engineering of artificial microswimmers. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  19. Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells.

    Science.gov (United States)

    Shimojo, Daisuke; Onodera, Kazunari; Doi-Torii, Yukiko; Ishihara, Yasuharu; Hattori, Chinatsu; Miwa, Yukino; Tanaka, Satoshi; Okada, Rina; Ohyama, Manabu; Shoji, Masanobu; Nakanishi, Atsushi; Doyu, Manabu; Okano, Hideyuki; Okada, Yohei

    2015-12-01

    Human pluripotent stem cells (hPSCs) are being applied in regenerative medicine and for the in vitro modeling of human intractable disorders. In particular, neural cells derived from disease-specific human induced pluripotent stem cells (hiPSCs) established from patients with neurological disorders have been used as in vitro disease models to recapitulate in vivo pathogenesis because neural cells cannot be usually obtained from patients themselves. In this study, we established a rapid, efficient, and simple method for efficiently deriving motor neurons from hPSCs that is useful for pathophysiological analysis and the development of drugs to treat motor neuron diseases. Treatment with GSK3β inhibitors during the initial phase of differentiation in combination with dual SMAD inhibition was sufficient to induce PAX6 (+) and SOX1 (+) neural progenitors within 1 week, and subsequent treatment with retinoic acid (RA) and purmorphamine, which activates sonic hedgehog (SHH) signaling, resulted in the highly efficient induction of HB9(+) and ISL-1(+) motor neurons within 2 weeks. After 4 weeks of monolayer differentiation in motor neuron maturation medium, hPSC-derived motor neurons were shown to mature, displaying larger somas and clearer staining for the mature motor neuron marker choline acetyltransferase (ChAT). Moreover, hPSC-derived motor neurons were able to form neuromuscular junctions with human myotubes in vitro and induced acetylcholine receptor (AChR) clustering, as detected by Alexa 555-conjugated α-Bungarotoxin (α-BTX), suggesting that these hPSC-derived motor neurons formed functional contacts with skeletal muscles. This differentiation system is simple and is reproducible in several hiPSC clones, thereby minimizing clonal variation among hPSC clones. We also established a system for visualizing motor neurons with a lentiviral reporter for HB9 (HB9 (e438) ::Venus). The specificity of this reporter was confirmed through immunocytochemistry and

  20. A modeling paradigm for interdisciplinary water resources modeling: Simple Script Wrappers (SSW)

    Science.gov (United States)

    Steward, David R.; Bulatewicz, Tom; Aistrup, Joseph A.; Andresen, Daniel; Bernard, Eric A.; Kulcsar, Laszlo; Peterson, Jeffrey M.; Staggenborg, Scott A.; Welch, Stephen M.

    2014-05-01

    Holistic understanding of a water resources system requires tools capable of model integration. This team has developed an adaptation of the OpenMI (Open Modelling Interface) that allows easy interactions across the data passed between models. Capabilities have been developed to allow programs written in common languages such as matlab, python and scilab to share their data with other programs and accept other program's data. We call this interface the Simple Script Wrapper (SSW). An implementation of SSW is shown that integrates groundwater, economic, and agricultural models in the High Plains region of Kansas. Output from these models illustrates the interdisciplinary discovery facilitated through use of SSW implemented models. Reference: Bulatewicz, T., A. Allen, J.M. Peterson, S. Staggenborg, S.M. Welch, and D.R. Steward, The Simple Script Wrapper for OpenMI: Enabling interdisciplinary modeling studies, Environmental Modelling & Software, 39, 283-294, 2013. http://dx.doi.org/10.1016/j.envsoft.2012.07.006 http://code.google.com/p/simple-script-wrapper/

  1. Analytic derivation of bacterial growth laws from a simple model of intracellular chemical dynamics.

    Science.gov (United States)

    Pandey, Parth Pratim; Jain, Sanjay

    2016-09-01

    Experiments have found that the growth rate and certain other macroscopic properties of bacterial cells in steady-state cultures depend upon the medium in a surprisingly simple manner; these dependencies are referred to as 'growth laws'. Here we construct a dynamical model of interacting intracellular populations to understand some of the growth laws. The model has only three population variables: an amino acid pool, a pool of enzymes that transport an external nutrient and produce the amino acids, and ribosomes that catalyze their own and the enzymes' production from the amino acids. We assume that the cell allocates its resources between the enzyme sector and the ribosomal sector to maximize its growth rate. We show that the empirical growth laws follow from this assumption and derive analytic expressions for the phenomenological parameters in terms of the more basic model parameters. Interestingly, the maximization of the growth rate of the cell as a whole implies that the cell allocates resources to the enzyme and ribosomal sectors in inverse proportion to their respective 'efficiencies'. The work introduces a mathematical scheme in which the cellular growth rate can be explicitly determined and shows that two large parameters, the number of amino acid residues per enzyme and per ribosome, are useful for making approximations.

  2. Insights: Simple Models for Teaching Equilibrium and Le Chatelier's Principle.

    Science.gov (United States)

    Russell, Joan M.

    1988-01-01

    Presents three models that have been effective for teaching chemical equilibrium and Le Chatelier's principle: (1) the liquid transfer model, (2) the fish model, and (3) the teeter-totter model. Explains each model and its relation to Le Chatelier's principle. (MVL)

  3. Simple down conversion nano-crystal coatings for enhancing Silicon-solar cells efficiency

    Directory of Open Access Journals (Sweden)

    Gur Mittelman

    2016-09-01

    Full Text Available Utilizing self-assembled nano-structured coatings on top of existing solar cells has thepotential to increase the total quantum efficiency of the cell using a simple and cheap process. In ourwork we have exploited the controlled absorption of nano-crystal with different band gaps to realizedown conversion artificial antennas that self-assembled on the device surface. The UV sun light isconverted to the visible light enhancing the solar cell performance in two complementary routes; a.protecting the solar cell and coatings from the UV illumination and therefore reducing the UVradiation damage. b. enhancing the total external quantum efficiency of the cell by one percent. Thisis achieved using a simple cheap process that can be adjusted to many different solar cells.

  4. A simple model for the nuclear unintegrated gluon distribution

    Energy Technology Data Exchange (ETDEWEB)

    Betemps, M.A. [Universidade Federal de Pelotas, Conjunto Agrotecnico Visconde da Graca, CAVG, Pelotas, RS (Brazil); Machado, M.V.T. [Universidade Federal do Pampa, Centro de Ciencias Exatas e Tecnologicas, Bage, RS (Brazil)

    2010-02-15

    The solution of non-linear evolution equations for dense nuclear gluon density has been suggested as one of the relevant mechanisms of pA and AA collisions at collider energies. Here we study a simple parameterization for the unintegrated gluon distribution using the knowledge of asymptotic solutions of the Balitsky-Kovchegov equation, describing high-energy QCD in the presence of saturation effects. A satisfactory description of nuclear shadowing at small x is obtained and it allows us to understand the qualitative behavior shown by the data. (orig.)

  5. The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikes.

    Science.gov (United States)

    Burroughs, Amelia; Wise, Andrew K; Xiao, Jianqiang; Houghton, Conor; Tang, Tianyu; Suh, Colleen Y; Lang, Eric J; Apps, Richard; Cerminara, Nadia L

    2017-01-01

    Purkinje cells are the sole output of the cerebellar cortex and fire two distinct types of action potential: simple spikes and complex spikes. Previous studies have mainly considered complex spikes as unitary events, even though the waveform is composed of varying numbers of spikelets. The extent to which differences in spikelet number affect simple spike activity (and vice versa) remains unclear. We found that complex spikes with greater numbers of spikelets are preceded by higher simple spike firing rates but, following the complex spike, simple spikes are reduced in a manner that is graded with spikelet number. This dynamic interaction has important implications for cerebellar information processing, and suggests that complex spike spikelet number may maintain Purkinje cells within their operational range. Purkinje cells are central to cerebellar function because they form the sole output of the cerebellar cortex. They exhibit two distinct types of action potential: simple spikes and complex spikes. It is widely accepted that interaction between these two types of impulse is central to cerebellar cortical information processing. Previous investigations of the interactions between simple spikes and complex spikes have mainly considered complex spikes as unitary events. However, complex spikes are composed of an initial large spike followed by a number of secondary components, termed spikelets. The number of spikelets within individual complex spikes is highly variable and the extent to which differences in complex spike spikelet number affects simple spike activity (and vice versa) remains poorly understood. In anaesthetized adult rats, we have found that Purkinje cells recorded from the posterior lobe vermis and hemisphere have high simple spike firing frequencies that precede complex spikes with greater numbers of spikelets. This finding was also evident in a small sample of Purkinje cells recorded from the posterior lobe hemisphere in awake cats. In addition

  6. Knock Prediction Using a Simple Model for Ignition Delay

    KAUST Repository

    Kalghatgi, Gautam

    2016-04-05

    An earlier paper has shown the ability to predict the phasing of knock onset in a gasoline PFI engine using a simple ignition delay equation for an appropriate surrogate fuel made up of toluene and PRF (TPRF). The applicability of this approach is confirmed in this paper in a different engine using five different fuels of differing RON, sensitivity, and composition - including ethanol blends. An Arrhenius type equation with a pressure correction for ignition delay can be found from interpolation of previously published data for any gasoline if its RON and sensitivity are known. Then, if the pressure and temperature in the unburned gas can be estimated or measured, the Livengood-Wu integral can be estimated as a function of crank angle to predict the occurrence of knock. Experiments in a single cylinder DISI engine over a wide operating range confirm that this simple approach can predict knock very accurately. The data presented should enable engineers to study knock or other auto-ignition phenomena e.g. in premixed compression ignition (PCI) engines without explicit chemical kinetic calculations. © Copyright 2016 SAE International.

  7. Building Mathematical Models of Simple Harmonic and Damped Motion.

    Science.gov (United States)

    Edwards, Thomas

    1995-01-01

    By developing a sequence of mathematical models of harmonic motion, shows that mathematical models are not right or wrong, but instead are better or poorer representations of the problem situation. (MKR)

  8. A simple numerical model of a geometrically nonlinear Timoshenko beam

    NARCIS (Netherlands)

    Keijdener, C.; Metrikine, A.

    2015-01-01

    In the original problem for which this model was developed, onedimensional flexible objects interact through a non-linear contact model. Due to the non-linear nature of the contact model, a numerical time-domain approach was adopted. One of the goals was to see if the coupling between axial and

  9. Simple mathematical models of symmetry breaking. Application to particle physics

    International Nuclear Information System (INIS)

    Michel, L.

    1976-01-01

    Some mathematical facts relevant to symmetry breaking are presented. A first mathematical model deals with the smooth action of compact Lie groups on real manifolds, a second model considers linear action of any group on real or complex finite dimensional vector spaces. Application of the mathematical models to particle physics is considered. (B.R.H.)

  10. Critical properties of a simple spin glass model

    International Nuclear Information System (INIS)

    Aharony, A.; Imry, Y.

    1976-01-01

    The Mattis spin glass model is described as following from a particular quenched random solid solution picture, and its zero-field properties are discussed. The random field model is reviewed. The application to the spin glass problem is made and the more general scaling theory presented, and the limitations of the model are discussed

  11. Anharmonic effects in simple physical models: introducing undergraduates to nonlinearity

    Science.gov (United States)

    Christian, J. M.

    2017-09-01

    Given the pervasive character of nonlinearity throughout the physical universe, a case is made for introducing undergraduate students to its consequences and signatures earlier rather than later. The dynamics of two well-known systems—a spring and a pendulum—are reviewed when the standard textbook linearising assumptions are relaxed. Some qualitative effects of nonlinearity can be anticipated from symmetry (e.g., inspection of potential energy functions), and further physical insight gained by applying a simple successive-approximation method that might be taught in parallel with courses on classical mechanics, ordinary differential equations, and computational physics. We conclude with a survey of how these ideas have been deployed on programmes at a UK university.

  12. An intercomparison of mesoscale models at simple sites for wind energy applications

    DEFF Research Database (Denmark)

    Olsen, Bjarke Tobias; Hahmann, Andrea N.; Sempreviva, Anna Maria

    2017-01-01

    of the output from 25 NWP models is presented for three sites in northern Europe characterized by simple terrain. The models are evaluated sing a number of statistical properties relevant to wind energy and verified with observations. On average the models have small wind speed biases offshore and aloft ( ... decreases the accuracy of the models, but we found no evidence that using a grid spacing smaller than 3 km is necessary for these simple sites. Applying the models to a simple wind energy offshore wind farm highlights the importance of capturing the correct distributions of wind speed and direction....

  13. A simple mathematical model for Ebola in Africa.

    Science.gov (United States)

    Berge, T; Lubuma, J M-S; Moremedi, G M; Morris, N; Kondera-Shava, R

    2017-12-01

    We deal with the following question: Can the consumption of contaminated bush meat, the funeral practices and the environmental contamination explain the recurrence and persistence of Ebola virus disease outbreaks in Africa? We develop an SIR-type model which, incorporates both the direct and indirect transmissions in such a manner that there is a provision of Ebola viruses. We prove that the full model has one (endemic) equilibrium which is locally asymptotically stable whereas, it is globally asymptotically stable in the absence of the Ebola virus shedding in the environment. For the sub-model without the provision of Ebola viruses, the disease dies out or stabilizes globally at an endemic equilibrium. At the endemic level, the number of infectious is larger for the full model than for the sub-model without provision of Ebola viruses. We design a nonstandard finite difference scheme, which preserves the dynamics of the model. Numerical simulations are provided.

  14. Simple models for the simulation of submarine melt for a Greenland glacial system model

    Directory of Open Access Journals (Sweden)

    J. Beckmann

    2018-01-01

    Full Text Available Two hundred marine-terminating Greenland outlet glaciers deliver more than half of the annually accumulated ice into the ocean and have played an important role in the Greenland ice sheet mass loss observed since the mid-1990s. Submarine melt may play a crucial role in the mass balance and position of the grounding line of these outlet glaciers. As the ocean warms, it is expected that submarine melt will increase, potentially driving outlet glaciers retreat and contributing to sea level rise. Projections of the future contribution of outlet glaciers to sea level rise are hampered by the necessity to use models with extremely high resolution of the order of a few hundred meters. That requirement in not only demanded when modeling outlet glaciers as a stand alone model but also when coupling them with high-resolution 3-D ocean models. In addition, fjord bathymetry data are mostly missing or inaccurate (errors of several hundreds of meters, which questions the benefit of using computationally expensive 3-D models for future predictions. Here we propose an alternative approach built on the use of a computationally efficient simple model of submarine melt based on turbulent plume theory. We show that such a simple model is in reasonable agreement with several available modeling studies. We performed a suite of experiments to analyze sensitivity of these simple models to model parameters and climate characteristics. We found that the computationally cheap plume model demonstrates qualitatively similar behavior as 3-D general circulation models. To match results of the 3-D models in a quantitative manner, a scaling factor of the order of 1 is needed for the plume models. We applied this approach to model submarine melt for six representative Greenland glaciers and found that the application of a line plume can produce submarine melt compatible with observational data. Our results show that the line plume model is more appropriate than the cone plume

  15. A simple but accurate procedure for solving the five-parameter model

    International Nuclear Information System (INIS)

    Mares, Oana; Paulescu, Marius; Badescu, Viorel

    2015-01-01

    Highlights: • A new procedure for extracting the parameters of the one-diode model is proposed. • Only the basic information listed in the datasheet of PV modules are required. • Results demonstrate a simple, robust and accurate procedure. - Abstract: The current–voltage characteristic of a photovoltaic module is typically evaluated by using a model based on the solar cell equivalent circuit. The complexity of the procedure applied for extracting the model parameters depends on data available in manufacture’s datasheet. Since the datasheet is not detailed enough, simplified models have to be used in many cases. This paper proposes a new procedure for extracting the parameters of the one-diode model in standard test conditions, using only the basic data listed by all manufactures in datasheet (short circuit current, open circuit voltage and maximum power point). The procedure is validated by using manufacturers’ data for six commercially crystalline silicon photovoltaic modules. Comparing the computed and measured current–voltage characteristics the determination coefficient is in the range 0.976–0.998. Thus, the proposed procedure represents a feasible tool for solving the five-parameter model applied to crystalline silicon photovoltaic modules. The procedure is described in detail, to guide potential users to derive similar models for other types of photovoltaic modules.

  16. Simple model for crop photosynthesis in terms of weather variables ...

    African Journals Online (AJOL)

    A theoretical mathematical model for describing crop photosynthetic rate in terms of the weather variables and crop characteristics is proposed. The model utilizes a series of efficiency parameters, each of which reflect the fraction of possible photosynthetic rate permitted by the different weather elements or crop architecture.

  17. Generic Graph Grammar: A Simple Grammar for Generic Procedural Modelling

    DEFF Research Database (Denmark)

    Christiansen, Asger Nyman; Bærentzen, Jakob Andreas

    2012-01-01

    Methods for procedural modelling tend to be designed either for organic objects, which are described well by skeletal structures, or for man-made objects, which are described well by surface primitives. Procedural methods, which allow for modelling of both kinds of objects, are few and usually of...

  18. Host extinction dynamics in a simple parasite-host interaction model.

    Science.gov (United States)

    Hwang, Tzy-Wei; Kuang, Yang

    2005-10-01

    This short article carefully formulate a simple SI model for a parasite-host interaction through the basic birth and death processes analysis. This model reveals and corrects an error in similar models studied recently by various authors. Complete mathematical investigation of this simple model shows that the host extinction dynamics can happen and the outcomes may depend on the initial conditions. We also present biological implications of our findings.

  19. Digital clocks: simple Boolean models can quantitatively describe circadian systems.

    Science.gov (United States)

    Akman, Ozgur E; Watterson, Steven; Parton, Andrew; Binns, Nigel; Millar, Andrew J; Ghazal, Peter

    2012-09-07

    The gene networks that comprise the circadian clock modulate biological function across a range of scales, from gene expression to performance and adaptive behaviour. The clock functions by generating endogenous rhythms that can be entrained to the external 24-h day-night cycle, enabling organisms to optimally time biochemical processes relative to dawn and dusk. In recent years, computational models based on differential equations have become useful tools for dissecting and quantifying the complex regulatory relationships underlying the clock's oscillatory dynamics. However, optimizing the large parameter sets characteristic of these models places intense demands on both computational and experimental resources, limiting the scope of in silico studies. Here, we develop an approach based on Boolean logic that dramatically reduces the parametrization, making the state and parameter spaces finite and tractable. We introduce efficient methods for fitting Boolean models to molecular data, successfully demonstrating their application to synthetic time courses generated by a number of established clock models, as well as experimental expression levels measured using luciferase imaging. Our results indicate that despite their relative simplicity, logic models can (i) simulate circadian oscillations with the correct, experimentally observed phase relationships among genes and (ii) flexibly entrain to light stimuli, reproducing the complex responses to variations in daylength generated by more detailed differential equation formulations. Our work also demonstrates that logic models have sufficient predictive power to identify optimal regulatory structures from experimental data. By presenting the first Boolean models of circadian circuits together with general techniques for their optimization, we hope to establish a new framework for the systematic modelling of more complex clocks, as well as other circuits with different qualitative dynamics. In particular, we anticipate

  20. Digital clocks: simple Boolean models can quantitatively describe circadian systems

    Science.gov (United States)

    Akman, Ozgur E.; Watterson, Steven; Parton, Andrew; Binns, Nigel; Millar, Andrew J.; Ghazal, Peter

    2012-01-01

    The gene networks that comprise the circadian clock modulate biological function across a range of scales, from gene expression to performance and adaptive behaviour. The clock functions by generating endogenous rhythms that can be entrained to the external 24-h day–night cycle, enabling organisms to optimally time biochemical processes relative to dawn and dusk. In recent years, computational models based on differential equations have become useful tools for dissecting and quantifying the complex regulatory relationships underlying the clock's oscillatory dynamics. However, optimizing the large parameter sets characteristic of these models places intense demands on both computational and experimental resources, limiting the scope of in silico studies. Here, we develop an approach based on Boolean logic that dramatically reduces the parametrization, making the state and parameter spaces finite and tractable. We introduce efficient methods for fitting Boolean models to molecular data, successfully demonstrating their application to synthetic time courses generated by a number of established clock models, as well as experimental expression levels measured using luciferase imaging. Our results indicate that despite their relative simplicity, logic models can (i) simulate circadian oscillations with the correct, experimentally observed phase relationships among genes and (ii) flexibly entrain to light stimuli, reproducing the complex responses to variations in daylength generated by more detailed differential equation formulations. Our work also demonstrates that logic models have sufficient predictive power to identify optimal regulatory structures from experimental data. By presenting the first Boolean models of circadian circuits together with general techniques for their optimization, we hope to establish a new framework for the systematic modelling of more complex clocks, as well as other circuits with different qualitative dynamics. In particular, we

  1. AT cells are not radiosensitive for simple chromosomal exchanges at low dose

    Energy Technology Data Exchange (ETDEWEB)

    Hada, Megumi; Huff, Janice L.; Patel, Zarana S. [USRA Division of Life Sciences, Houston, TX 77058 (United States); Kawata, Tetsuya [Department of Radiology, School of Medicine, Keio University, Tokyo (Japan); Pluth, Janice M. [Lawrence Berkeley National Laboratory, Life Sciences Division, One Cyclotron Road, Building 74, Berkeley, CA 94720 (United States); George, Kerry A. [Wyle, 1290 Hercules Drive, Houston, TX 77058 (United States); Cucinotta, Francis A., E-mail: Francis.A.Cucinotta@nasa.gov [NASA, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, TX 77058 (United States)

    2011-11-01

    Cells deficient in ATM (product of the gene that is mutated in ataxia telangiectasia patients) or NBS (product of the gene mutated in the Nijmegen breakage syndrome) show increased yields of both simple and complex chromosomal aberrations after high doses (>0.5 Gy) of ionizing radiation (X-rays or {gamma}-rays), however less is known on how these cells respond at low dose. Previously we had shown that the increased chromosome aberrations in ATM and NBS defective lines was due to a significantly larger quadratic dose-response term compared to normal fibroblasts for both simple and complex exchanges. The linear dose-response term for simple exchanges was significantly higher in NBS cells compared to wild type cells, but not for AT cells. However, AT cells have a high background level of exchanges compared to wild type or NBS cells that confounds the understanding of low dose responses. To understand the sensitivity differences for high to low doses, chromosomal aberration analysis was first performed at low dose-rates (0.5 Gy/d), and results provided further evidence for the lack of sensitivity for exchanges in AT cells below doses of 1 Gy. Normal lung fibroblast cells treated with KU-55933, a specific ATM kinase inhibitor, showed increased numbers of exchanges at a dose of 1 Gy and higher, but were similar to wild type cells at 0.5 Gy or below. These results were confirmed using siRNA knockdown of ATM. The present study provides evidence that the increased radiation sensitivity of AT cells for chromosomal exchanges found at high dose does not occur at low dose.

  2. AT cells are not radiosensitive for simple chromosomal exchanges at low dose

    International Nuclear Information System (INIS)

    Hada, Megumi; Huff, Janice L.; Patel, Zarana S.; Kawata, Tetsuya; Pluth, Janice M.; George, Kerry A.; Cucinotta, Francis A.

    2011-01-01

    Cells deficient in ATM (product of the gene that is mutated in ataxia telangiectasia patients) or NBS (product of the gene mutated in the Nijmegen breakage syndrome) show increased yields of both simple and complex chromosomal aberrations after high doses (>0.5 Gy) of ionizing radiation (X-rays or γ-rays), however less is known on how these cells respond at low dose. Previously we had shown that the increased chromosome aberrations in ATM and NBS defective lines was due to a significantly larger quadratic dose-response term compared to normal fibroblasts for both simple and complex exchanges. The linear dose-response term for simple exchanges was significantly higher in NBS cells compared to wild type cells, but not for AT cells. However, AT cells have a high background level of exchanges compared to wild type or NBS cells that confounds the understanding of low dose responses. To understand the sensitivity differences for high to low doses, chromosomal aberration analysis was first performed at low dose-rates (0.5 Gy/d), and results provided further evidence for the lack of sensitivity for exchanges in AT cells below doses of 1 Gy. Normal lung fibroblast cells treated with KU-55933, a specific ATM kinase inhibitor, showed increased numbers of exchanges at a dose of 1 Gy and higher, but were similar to wild type cells at 0.5 Gy or below. These results were confirmed using siRNA knockdown of ATM. The present study provides evidence that the increased radiation sensitivity of AT cells for chromosomal exchanges found at high dose does not occur at low dose.

  3. There Is No Simple Model of the Plasma Membrane Organization

    Science.gov (United States)

    Bernardino de la Serna, Jorge; Schütz, Gerhard J.; Eggeling, Christian; Cebecauer, Marek

    2016-01-01

    Ever since technologies enabled the characterization of eukaryotic plasma membranes, heterogeneities in the distributions of its constituents were observed. Over the years this led to the proposal of various models describing the plasma membrane organization such as lipid shells, picket-and-fences, lipid rafts, or protein islands, as addressed in numerous publications and reviews. Instead of emphasizing on one model we in this review give a brief overview over current models and highlight how current experimental work in one or the other way do not support the existence of a single overarching model. Instead, we highlight the vast variety of membrane properties and components, their influences and impacts. We believe that highlighting such controversial discoveries will stimulate unbiased research on plasma membrane organization and functionality, leading to a better understanding of this essential cellular structure. PMID:27747212

  4. A simple model for assessing utilisable streamflow allocations in the ...

    African Journals Online (AJOL)

    -sized water resource systems (without major storage) and displays the results as flow duration curves so that they can be compared with the standard information available for the Ecological Reserve requirements. The model is designed to ...

  5. Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Vakhrushev, Sergey Y; Vester-Christensen, Malene B

    2011-01-01

    -glycopeptides from total cell lysates using lectin chromatography and nanoflow liquid chromatography-mass spectrometry (nLC-MS/MS) with electron transfer dissociation fragmentation. We identified >100 O-glycoproteins with >350 O-glycan sites (the great majority previously unidentified), including a GalNAc O......-glycan linkage to a tyrosine residue. The SimpleCell method should facilitate analyses of important functions of protein glycosylation. The strategy is also applicable to other O-glycoproteomes....

  6. A simple improvement of the conventional cryopreservation for human ES and iPS cells

    OpenAIRE

    sprotocols

    2014-01-01

    Authors: Midori Ozawa, Yutaka Ozawa, Masashi Iemura, Arihiro Kohara, Kana Yanagihara & Miho K Furue ### Abstract In this study, a simple method for the cryopreservation of human embryonic stem (ES) and induced pluripotent stem (iPS) cells is proposed. It is based on the conventional slow-freezing method with 10% DMSO and modified mainly in a thawing protocol without specific equipment or reagents. Recovery rate of the cells cryopreserved by this method was equally high, which is compa...

  7. Mathematical modeling of the evolution of a simple biological system

    Digital Repository Service at National Institute of Oceanography (India)

    Gonsalves, M.J.B.D.; Neetu, S.; Krishnan, K.P.; Attri, K.; LokaBharathi, P.A.

    Paula, Goa 403 004, India. Phone: +91 0832 2450624, Fax: +91 0832 2450606, e-mail: mjudith@nio.org Introduction In India, classroom education in biology does not generally include an exercise in which the data can be used to develop models.... This has hampered exposure to quantitative tools in biology, much to the disadvantage of students. The purpose of this note is to report an exercise we carried out to expose traditional biologists educated in India to mathematical modelling of biological...

  8. A simple delay model for two-phase flow dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Clausse, A.; Delmastro, D.F.; Juanico`, L.E. [Centro Atomico Bariloche (Argentina)

    1995-09-01

    A model based in delay equations for density-wave oscillations is presented. High Froude numbers and moderate ones were considered. The equations were numerically analyzed and compared with more sophisticated models. The influence of the gravity term was studied. Different kinds of behavior were found, particularly sub-critical and super-critical Hopf bifurcations. Moreover the present approach can be used to better understand the complicated dynamics of boiling flows systems.

  9. Developing and Implementing a Simple, Affordable Hydrogen Fuel Cell Laboratory in Introductory Chemistry

    Science.gov (United States)

    Klara, Kristina; Hou, Ning; Lawman, Allison; Wu, Liheng; Morrill, Drew; Tente, Alfred; Wang, Li-Qiong

    2014-01-01

    A simple, affordable hydrogen proton exchange membrane (PEM) fuel cell laboratory was developed through a collaborative effort between faculty and undergraduate students at Brown University. It has been incorporated into the introductory chemistry curriculum and successfully implemented in a class of over 500 students per academic year for over 3…

  10. Improved Analysis of Earth System Models and Observations using Simple Climate Models

    Science.gov (United States)

    Nadiga, Balasubramanya; Urban, Nathan

    2017-04-01

    First-principles-based Earth System Models (ESMs) are central to both improving our understanding of the climate system and developing climate projections. Nevertheless, given the diversity of climate simulated by the various ESMs and the intense computational burden associated with running such models, simple climate models (SCMs) are key to being able to compare ESMs and the climates they simulate in a dynamically meaningful fashion. We present some preliminary work along these lines. In an application of an SCM to compare different ESMs and observations, we demonstrate a deficiency in the commonly-used upwelling-diffusion (UD) energy balance model (EBM). When we consider the vertical distribution of ocean heat uptake, the lack of representation of processes such as deep water formation and subduction in the UD-EBM precludes a reasonable representation of the vertical distribution of heat uptake in that model. We then demonstrate how the problem can be remedied by introducing a parameterization of such processes in the UD-EBM. With further development, it is anticipated that this approach of ESM inter-comparison using simple physics-based models will lead to further insights into aspects of the climate response such as its stability and sensitivity, uncertainty and predictability, and underlying flow structure and topology.

  11. A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture.

    Science.gov (United States)

    Freund, Nathaniel W; Croughan, Matthew S

    2018-01-28

    Fed-batch animal cell culture is the most common method for commercial production of recombinant proteins. However, higher cell densities in these platforms are still limited due to factors such as excessive ammonium production, lactic acid production, nutrient limitation, and/or hyperosmotic stress related to nutrient feeds and base additions to control pH. To partly overcome these factors, we investigated a simple method to reduce both ammonium and lactic acid production-termed Lactate Supplementation and Adaptation (LSA) technology-through the use of CHO cells adapted to a lactate-supplemented medium. Using this simple method, we achieved a reduction of nearly 100% in lactic acid production with a simultaneous 50% reduction in ammonium production in batch shaker flasks cultures. In subsequent fed-batch bioreactor cultures, lactic acid production and base addition were both reduced eight-fold. Viable cell densities of 35 million cells per mL and integral viable cell days of 273 million cell-days per mL were achieved, both among the highest currently reported for a fed-batch animal cell culture. Investigating the benefits of LSA technology in animal cell culture is worthy of further consideration and may lead to process conditions more favorable for advanced industrial applications.

  12. A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

    Science.gov (United States)

    Freund, Nathaniel W.; Croughan, Matthew S.

    2018-01-01

    Fed-batch animal cell culture is the most common method for commercial production of recombinant proteins. However, higher cell densities in these platforms are still limited due to factors such as excessive ammonium production, lactic acid production, nutrient limitation, and/or hyperosmotic stress related to nutrient feeds and base additions to control pH. To partly overcome these factors, we investigated a simple method to reduce both ammonium and lactic acid production—termed Lactate Supplementation and Adaptation (LSA) technology—through the use of CHO cells adapted to a lactate-supplemented medium. Using this simple method, we achieved a reduction of nearly 100% in lactic acid production with a simultaneous 50% reduction in ammonium production in batch shaker flasks cultures. In subsequent fed-batch bioreactor cultures, lactic acid production and base addition were both reduced eight-fold. Viable cell densities of 35 million cells per mL and integral viable cell days of 273 million cell-days per mL were achieved, both among the highest currently reported for a fed-batch animal cell culture. Investigating the benefits of LSA technology in animal cell culture is worthy of further consideration and may lead to process conditions more favorable for advanced industrial applications. PMID:29382079

  13. Relativistic generalizations of simple pion-nucleon models

    International Nuclear Information System (INIS)

    McLeod, R.J.; Ernst, D.J.

    1981-01-01

    A relativistic, partial wave N/D dispersion theory is developed for low energy pion-nucleon elastic scattering. The theory is simplified by treating crossing symmetry only to lowest order in the inverse nucleon mass. The coupling of elastic scattering to inelastic channels is included by taking the necessary inelasticity from experimental data. Three models are examined: pseudoscalar coupling of pions and nucleons, pseudovector coupling, and a model in which all intermediate antinucleons are projected out of the amplitude. The phase shifts in the dominant P 33 channel are quantitatively reproduced for P/sub lab/ 33 phase shifts. Thus a model of the pion-nucleon interaction which does not include antinucleon degrees of freedom is found to be unphysical

  14. A simple model for fatigue crack growth in concrete applied to a hinge beam model

    DEFF Research Database (Denmark)

    Skar, Asmus; Poulsen, Peter Noe; Olesen, John Forbes

    2017-01-01

    In concrete structures, fatigue is one of the major causes of material deterioration. Repeated loads result in formation of cracks. Propagation of these cracks cause internal progressive damage within the concrete material which ultimately leads to failure. This paper presents a simplified general...... concept for non-linear analysis of concrete subjected to cyclic loading. The model is based on the fracture mechanics concepts of the fictitious crack model, considering a fiber of concrete material, and a simple energy based approach for estimating the bridging stress under cyclic loading. Further...

  15. Problems with a simple-minded cluster model

    International Nuclear Information System (INIS)

    Adhikari, S.K.

    1980-01-01

    Cluster model approximation for the resolvent operator can reduce many-body Lippmann-Schwinger equations to an efective two-body equation. It is shown that such approximation may suppress mathematical mechanisms for rearrangement processes. This leads then to highly reduced wave functions and weak effective intercluster potentials. (L.C.) [pt

  16. A simple model for assessing utilisable streamflow allocations in the ...

    African Journals Online (AJOL)

    2006-07-03

    Jul 3, 2006 ... Ecological Reserve) in South Africa recognises the natural vari- ability of flow regimes and that some of ... using a system yield model in which the Ecological Reserve is treated as a high priority user and ..... metadata within memo type attributes that can be used to store comments about data sources and ...

  17. There Is No Simple Model of the Plasma Membrane Organization

    Czech Academy of Sciences Publication Activity Database

    de la serna, J. B.; Schütz, G.; Eggeling, Ch.; Cebecauer, Marek

    2016-01-01

    Roč. 4, SEP 2016 (2016), 106 ISSN 2296-634X R&D Projects: GA ČR GA15-06989S Institutional support: RVO:61388955 Keywords : plasma membrane * membrane organization models * heterogeneous distribution Subject RIV: CF - Physical ; Theoretical Chemistry

  18. Water and Aqueous Solutions: Simple Non-Speculative Model Approach

    Czech Academy of Sciences Publication Activity Database

    Nezbeda, Ivo; Jirsák, Jan

    2011-01-01

    Roč. 13, č. 44 (2011), s. 19689-19703 ISSN 1463-9076 R&D Projects: GA AV ČR IAA400720802; GA AV ČR IAA200760905 Institutional research plan: CEZ:AV0Z40720504 Keywords : molecular modeling of water * separation * perturbation Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.573, year: 2011

  19. Modeling Windows in Energy Plus with Simple Performance Indices

    Energy Technology Data Exchange (ETDEWEB)

    Arasteh, Dariush; Kohler, Christian; Griffith, Brent

    2009-10-12

    The building energy simulation program, Energy Plus (E+), cannot use standard window performance indices (U, SHGC, VT) to model window energy impacts. Rather, E+ uses more accurate methods which require a physical description of the window. E+ needs to be able to accept U and SHGC indices as window descriptors because, often, these are all that is known about a window and because building codes, standards, and voluntary programs are developed using these terms. This paper outlines a procedure, developed for E+, which will allow it to use standard window performance indices to model window energy impacts. In this 'Block' model, a given U, SHGC, VT are mapped to the properties of a fictitious 'layer' in E+. For thermal conductance calculations, the 'Block' functions as a single solid layer. For solar optical calculations, the model begins by defining a solar transmittance (Ts) at normal incidence based on the SHGC. For properties at non-normal incidence angles, the 'Block' takes on the angular properties of multiple glazing layers; the number and type of layers defined by the U and SHGC. While this procedure is specific to E+, parts of it may have applicability to other window/building simulation programs.

  20. Determining input values for a simple parametric model to estimate ...

    African Journals Online (AJOL)

    Estimating soil evaporation (Es) is an important part of modelling vineyard evapotranspiration for irrigation purposes. Furthermore, quantification of possible soil texture and trellis effects is essential. Daily Es from six topsoils packed into lysimeters was measured under grapevines on slanting and vertical trellises, ...

  1. Development of a Simple Hydraulic Performance Model for ...

    African Journals Online (AJOL)

    ... model prediction is proposed. The procedure for conducting the field flow test in the determination of the Hazen William's friction factor is described by utilizing the set up and data of the field flow test carried out on 11th August 1988 on completion of the swabbing exercise. Journal of Civil Engineering, JKUAT (2001) Vol 6, ...

  2. A Computer Model of Simple Forms of Learning.

    Science.gov (United States)

    Jones, Thomas L.

    A basic unsolved problem in science is that of understanding learning, the process by which people and machines use their experience in a situation to guide future action in similar situations. The ideas of Piaget, Pavlov, Hull, and other learning theorists, as well as previous heuristic programing models of human intelligence, stimulated this…

  3. Production compilation : A simple mechanism to model complex skill acquisition

    NARCIS (Netherlands)

    Taatgen, N.A.; Lee, F.J.

    2003-01-01

    In this article we describe production compilation, a mechanism for modeling skill acquisition. Production compilation has been developed within the ACT-Rational (ACT-R; J. R. Anderson, D. Bothell, M. D. Byrne, & C. Lebiere, 2002) cognitive architecture and consists of combining and specializing

  4. A simple, dynamic, hydrological model of a mesotidal salt marsh

    Science.gov (United States)

    Salt marsh hydrology presents many difficulties from a modeling standpoint: the bi-directional flows of tidal waters, variable water densities due to mixing of fresh and salt water, significant influences from vegetation, and complex stream morphologies. Because of these difficu...

  5. Modelling the transition from simple to complex Ca oscillations in ...

    Indian Academy of Sciences (India)

    2014-04-29

    Apr 29, 2014 ... 2Department of Mathematics, University of Auckland, Private Bag 92019, Auckland, New Zealand. *Corresponding author (Fax, +91-755-2670562; Email, mannumanhas@gmail.com). A mathematical model is proposed which systematically investigates complex calcium oscillations in pancreatic.

  6. A simple model of big-crunch/big-bang transition

    Energy Technology Data Exchange (ETDEWEB)

    Malkiewicz, Przemyslaw; Piechocki, Wlodzimierz [Department of Theoretical Physics, Soltan Institute for Nuclear Studies, Hoza 69, 00-681 Warsaw (Poland)

    2006-05-07

    We present classical and quantum dynamics of a test particle in the compactified Milne space. Background spacetime includes one compact space dimension undergoing contraction to a point followed by expansion. Quantization consists in finding a self-adjoint representation of the algebra of particle observables. Our model offers some insight into the nature of the cosmic singularity.

  7. Simplicity, inference and modelling: keeping it sophisticatedly simple

    National Research Council Canada - National Science Library

    Zellner, Arnold; Keuzenkamp, Hugo A; McAleer, Michael

    2001-01-01

    .... What is meant by simplicity? How is simplicity measured? Is there an optimum trade-off between simplicity and goodness-of-fit? What is the relation between simplicity and empirical modelling? What is the relation between simplicity and prediction? What is the connection between simplicity and convenience? The book concludes with reflect...

  8. A simple tissue model for practicing ultrasound guided vascular ...

    African Journals Online (AJOL)

    Introduction: The use of ultrasound in anaesthetic practice continues to be more established and the use of ultrasound guidance in establishing vascular access is recommended by various groups. We have developed a tissue model for the practice and skills development in ultrasound vascular access. Method: The tissue ...

  9. Overall feature of EAST operation space by using simple Core-SOL-Divertor model

    International Nuclear Information System (INIS)

    Hiwatari, R.; Hatayama, A.; Zhu, S.; Takizuka, T.; Tomita, Y.

    2005-01-01

    We have developed a simple Core-SOL-Divertor (C-S-D) model to investigate qualitatively the overall features of the operational space for the integrated core and edge plasma. To construct the simple C-S-D model, a simple core plasma model of ITER physics guidelines and a two-point SOL-divertor model are used. The simple C-S-D model is applied to the study of the EAST operational space with lower hybrid current drive experiments under various kinds of trade-off for the basic plasma parameters. Effective methods for extending the operation space are also presented. As shown by this study for the EAST operation space, it is evident that the C-S-D model is a useful tool to understand qualitatively the overall features of the plasma operation space. (author)

  10. Lagrangian analysis of explosive models with simple inner structures

    International Nuclear Information System (INIS)

    Daneri, A.; Trombetti, G.

    1983-01-01

    Fast reactor model explosive experiments with inner structures interposed between the explosive energy source and the containment vessel have been analyzed in the paper, with reference to the COVA saries experiments IT/10, IT/11, It/12. Capability and limitations of a Lagrangian fluid dynamics analysis in such expe-rimental conditions have been discussed. The ENEA version of the Lagrangian code ASTARTE-4 has been used in the computations

  11. A simple spatiotemporal evolution model of a transmission power grid

    OpenAIRE

    Rosas Casals, Martí; Valverde, Sergi; Solé, Ricard Vicenç

    2018-01-01

    In this paper, we present a model for the spatial and temporal evolution of a particularly large human-made network: the 400-kV French transmission power grid. This is based on 1) an attachment procedure that diminishes the connection probability between two nodes as the network grows and 2) a coupled cost function characterizing the available budget at every time step. Two differentiated and consecutive processes can be distinguished: a first global space-filling process and a secondary loca...

  12. A Simple Model for Human and Nature Interaction

    Science.gov (United States)

    Motesharrei, S.; Rivas, J.; Kalnay, E.

    2012-12-01

    There are widespread concerns that current trends in population and resource-use are unsustainable, but the possibilities of an overshoot and collapse remain unclear and controversial. Collapses of civilizations have occurred many times in the past 5000 years, often followed by centuries of economic, intellectual, and population decline. Many different natural and social phenomena have been invoked to explain specific collapses, but a general explanation remains elusive. Two important features seem to appear across societies that have collapsed: Ecological Strain and Economic Stratification. Our new model (Human And Nature DYnamics, HANDY) has just four equations that describe the evolution of Elites, Commoners, Nature, and Wealth. Mechanisms leading to collapse are discussed and the measure "Carrying Capacity" is developed and defined. The model shows that societal collapse can happen due to either one of two independent factors: (1) over-consumption of natural resources, and/or (2) deep inequity between Elites and Commoners. The model also portrays two distinct types of collapse: (i) collapse followed by recovery of nature, and (ii) full collapse. The model suggests that the estimation of Carrying Capacity is a practical means for early detection of a collapse. Collapse can be avoided, and population can reach a sustainable equilibrium, if the rate of depletion of nature is reduced to a sustainable level, and if resources are distributed in a reasonably equitable fashion.; A type-ii (full) collapse is shown in this figure. With high inequality and high depletion, societies are doomed to collapse. Wealth starts to decrease when population rises above the carrying capacity. The large gap between carrying capacity and its maximum is a result of depletion factor being much larger than the sustainable limit. ; It is possible to overshoot, oscillate, and eventually converge to an equilibrium, even in an inequitable society. However, it requires policies that control

  13. Understanding the inverse magnetocaloric effect through a simple theoretical model

    Energy Technology Data Exchange (ETDEWEB)

    Ranke, P.J. von, E-mail: von.ranke@uol.com.b [Instituto de Fisica Armando Dias Tavares-Universidade do Estado do Rio de Janeiro, Rua Sao Francisco Xavier, 524, Rio de Janeiro 20550-013 (Brazil); Alho, B.P.; Nobrega, E.P.; Oliveira, N.A. de [Instituto de Fisica Armando Dias Tavares-Universidade do Estado do Rio de Janeiro, Rua Sao Francisco Xavier, 524, Rio de Janeiro 20550-013 (Brazil)

    2009-10-15

    We investigated the inverse magnetocaloric effect using a theoretical magnetic model formed by two coupled magnetic lattices to describe a ferrimagnetic system. The influence of the compensation temperature, and the ferrimagnetic-paramagnetic phase transition on the magnetocaloric effect was analyzed. Also, a relation between the area under the magnetocaloric curve and the net magnetic moment of a ferrimagnetic system was established in this work.

  14. Caenorhabditis elegans: a simple nematode infection model for Penicillium marneffei.

    Directory of Open Access Journals (Sweden)

    Xiaowen Huang

    Full Text Available Penicillium marneffei, one of the most important thermal dimorphic fungi, is a severe threat to the life of immunocompromised patients. However, the pathogenic mechanisms of P. marneffei remain largely unknown. In this work, we developed a model host by using nematode Caenorhabditis elegans to investigate the virulence of P. marneffei. Using two P. marneffei clinical isolate strains 570 and 486, we revealed that in both liquid and solid media, the ingestion of live P. marneffei was lethal to C. elegans (P<0.001. Meanwhile, our results showed that the strain 570, which can produce red pigment, had stronger pathogenicity in C. elegans than the strain 486, which can't produce red pigment (P<0.001. Microscopy showed the formation of red pigment and hyphae within C. elegans after incubation with P. marneffei for 4 h, which are supposed to be two contributors in nematodes killing. In addition, we used C. elegans as an in vivo model to evaluate different antifungal agents against P. marneffei, and found that antifungal agents including amphotericin B, terbinafine, fluconazole, itraconazole and voriconazole successfully prolonged the survival of nematodesinfected by P. marneffei. Overall, this alternative model host can provide us an easy tool to study the virulence of P. marneffei and screen antifungal agents.

  15. Nonperturbative Time Dependent Solution of a Simple Ionization Model

    Science.gov (United States)

    Costin, Ovidiu; Costin, Rodica D.; Lebowitz, Joel L.

    2018-02-01

    We present a non-perturbative solution of the Schrödinger equation {iψ_t(t,x)=-ψ_{xx}(t,x)-2(1 +α sinω t) δ(x)ψ(t,x)} , written in units in which \\hbar=2m=1, describing the ionization of a model atom by a parametric oscillating potential. This model has been studied extensively by many authors, including us. It has surprisingly many features in common with those observed in the ionization of real atoms and emission by solids, subjected to microwave or laser radiation. Here we use new mathematical methods to go beyond previous investigations and to provide a complete and rigorous analysis of this system. We obtain the Borel-resummed transseries (multi-instanton expansion) valid for all values of α, ω, t for the wave function, ionization probability, and energy distribution of the emitted electrons, the latter not studied previously for this model. We show that for large t and small α the energy distribution has sharp peaks at energies which are multiples of ω, corresponding to photon capture. We obtain small α expansions that converge for all t, unlike those of standard perturbation theory. We expect that our analysis will serve as a basis for treating more realistic systems revealing a form of universality in different emission processes.

  16. NEARSOL - a simple program to model actinide speciation and solubility under waste disposal conditions

    International Nuclear Information System (INIS)

    Leach, S.J.; Pryke, D.C.

    1986-05-01

    A simple program, NearSol, has been written in Fortran 77 on the Harwell Central Computer to model the aqueous speciation and solubility of actinides under near-field conditions for disposal using a simple thermodynamic approach. The methodology and running of the program are described together with a worked example. (author)

  17. Simple and inexpensive technique for measuring oxygen consumption rate in adherent cultured cells.

    Science.gov (United States)

    Takahashi, Eiji; Yamaoka, Yoshihisa

    2017-11-01

    Measurement of cellular oxygen consumption rate (OCR) is essential in assessing roles of mitochondria in physiology and pathophysiology. Classical techniques, in which polarographic oxygen electrode measures the extracellular oxygen concentration in a closed measuring vessel, require isolation and suspension of the cell. Because cell functions depend on the extracellular milieu including the extracellular matrix, isolation of cultured cells prior to the measurement may significantly affect the OCR. More recent techniques utilize optical methods in which oxygen-dependent quenching of fluorophores determines oxygen concentration in the medium at a few microns above the surface of the cultured cells. These techniques allow the OCR measurement in cultured cells adhered to the culture dish. However, this technique requires special equipment such as a fluorescence lifetime microplate reader or specialized integrated system, which are usually quite expensive. Here, we introduce a simple and inexpensive technique for measuring OCR in adherent cultured cells that utilizes conventional fluorescence microscopy and a glassware called a gap cover glass.

  18. Calcium Imaging Reveals Coordinated Simple Spike Pauses in Populations of Cerebellar Purkinje Cells

    Directory of Open Access Journals (Sweden)

    Jorge E. Ramirez

    2016-12-01

    Full Text Available The brain’s control of movement is thought to involve coordinated activity between cerebellar Purkinje cells. The results reported here demonstrate that somatic Ca2+ imaging is a faithful reporter of Na+-dependent “simple spike” pauses and enables us to optically record changes in firing rates in populations of Purkinje cells in brain slices and in vivo. This simultaneous calcium imaging of populations of Purkinje cells reveals a striking spatial organization of pauses in Purkinje cell activity between neighboring cells. The source of this organization is shown to be the presynaptic gamma-Aminobutyric acid producing (GABAergic network, and blocking ionotropic gamma-Aminobutyric acid receptor (GABAARs abolishes the synchrony. These data suggest that presynaptic interneurons synchronize (inactivity between neighboring Purkinje cells, and thereby maximize their effect on downstream targets in the deep cerebellar nuclei.

  19. A simple nanostructured polymer/ZnO hybrid solar cell - preparation and operation in air

    DEFF Research Database (Denmark)

    Krebs, Frederik C; Thomann, Yi; Thomann, Ralf

    2008-01-01

    A detailed description is given of the preparation of a polymer solar cell and its characterization. The solar cell can be prepared entirely in the ambient atmosphere by solution processing without the use of vacuum coating steps, and it can be operated in the ambient atmosphere with good......)-oxy-carbonyldithiophene) (P3MHOCT), which through a thermal treatment is converted to the insoluble form poly(3-carboxydithiophene) (P3CT) that generally gives stable polymer solar cells. The devices employed a solution based silver back electrode. One advantage is that preparation of the devices is very simple and can...

  20. Variations within simple models for structure-soil interaction

    DEFF Research Database (Denmark)

    Peplow, Andrew; Andersen, Lars Vabbersgaard; Bucinskas, Paulius

    The dynamic response of blocks sitting on a half-space is considered. Buildings and other structures placed on or within the ground influence the transmission of seismic waves. Hence, the presence of a building will have an impact on the dynamic response of neighbouring buildings. Furthermore......, obstacles such as concrete blocks lead to wave scattering that may be beneficial or unfavourable for the response of a building close to, for example, a railway. To account for this dynamic cross coupling via the soil, a model must be accurate enough to provide the correct overall behaviour of the scattered...

  1. Spatio-temporal patterns in simple models of marine systems

    Science.gov (United States)

    Feudel, U.; Baurmann, M.; Gross, T.

    2009-04-01

    Spatio-temporal patterns in marine systems are a result of the interaction of population dynamics with physical transport processes. These physical transport processes can be either diffusion processes in marine sediments or in the water column. We study the dynamics of one population of bacteria and its nutrient in in a simplified model of a marine sediments, taking into account that the considered bacteria possess an active as well as an inactive state, where activation is processed by signal molecules. Furthermore the nutrients are transported actively by bioirrigation and passively by diffusion. It is shown that under certain conditions Turing patterns can occur which yield heterogeneous spatial patterns of the species. The influence of bioirrigation on Turing patterns leads to the emergence of ''hot spots``, i.e. localized regions of enhanced bacterial activity. All obtained patterns fit quite well to observed patterns in laboratory experiments. Spatio-temporal patterns appear in a predator-prey model, used to describe plankton dynamics. These patterns appear due to the simultaneous emergence of Turing patterns and oscillations in the species abundance in the neighborhood of a Turing-Hopf bifurcation. We observe a large variety of different patterns where i) stationary heterogeneous patterns (e.g. hot and cold spots) compete with spatio-temporal patterns ii) slowly moving patterns are embedded in an oscillatory background iii) moving fronts and spiral waves appear.

  2. Feature extraction through least squares fit to a simple model

    International Nuclear Information System (INIS)

    Demuth, H.B.

    1976-01-01

    The Oak Ridge National Laboratory (ORNL) presented the Los Alamos Scientific Laboratory (LASL) with 18 radiographs of fuel rod test bundles. The problem is to estimate the thickness of the gap between some cylindrical rods and a flat wall surface. The edges of the gaps are poorly defined due to finite source size, x-ray scatter, parallax, film grain noise, and other degrading effects. The radiographs were scanned and the scan-line data were averaged to reduce noise and to convert the problem to one dimension. A model of the ideal gap, convolved with an appropriate point-spread function, was fit to the averaged data with a least squares program; and the gap width was determined from the final fitted-model parameters. The least squares routine did converge and the gaps obtained are of reasonable size. The method is remarkably insensitive to noise. This report describes the problem, the techniques used to solve it, and the results and conclusions. Suggestions for future work are also given

  3. A simple phenomenological model for time evolution of social networks

    Science.gov (United States)

    Jiang, J.; Wang, Q. A.; Li, W.; Cai, X.

    2015-04-01

    Inspired by the maxim ”long union divides and long division unites”, a phenomenological model with the simplification of real social networks is proposed to explore the evolutionary features of these networks composed of the entities whose behaviors are dominated by two events: union and division. The nodes are endowed with some attributes such as identity, ingredient, richness, age and internal diversity, which determine collectively the evolution in a probabilistic way. Through the local interaction of two events, a stationary state of network is reached as a constant amount of nodes survive with no more event happened in the network, like a situation of tripartite confrontation. Besides, the number of survived nodes and the speed of network evolution can be controlled by two parameters.

  4. A constitutive model for simple shear of dense frictional suspensions

    Science.gov (United States)

    Singh, Abhinendra; Mari, Romain; Denn, Morton M.; Morris, Jeffrey F.

    2018-03-01

    Discrete particle simulations are used to study the shear rheology of dense, stabilized, frictional particulate suspensions in a viscous liquid, toward development of a constitutive model for steady shear flows at arbitrary stress. These suspensions undergo increasingly strong continuous shear thickening (CST) as solid volume fraction $\\phi$ increases above a critical volume fraction, and discontinuous shear thickening (DST) is observed for a range of $\\phi$. When studied at controlled stress, the DST behavior is associated with non-monotonic flow curves of the steady-state stress as a function of shear rate. Recent studies have related shear thickening to a transition between mostly lubricated to predominantly frictional contacts with the increase in stress. In this study, the behavior is simulated over a wide range of the dimensionless parameters $(\\phi,\\tilde{\\sigma}$, and $\\mu)$, with $\\tilde{\\sigma} = \\sigma/\\sigma_0$ the dimensionless shear stress and $\\mu$ the coefficient of interparticle friction: the dimensional stress is $\\sigma$, and $\\sigma_0 \\propto F_0/ a^2$, where $F_0$ is the magnitude of repulsive force at contact and $a$ is the particle radius. The data have been used to populate the model of the lubricated-to-frictional rheology of Wyart and Cates [Phys. Rev. Lett.{\\bf 112}, 098302 (2014)], which is based on the concept of two viscosity divergences or \\textquotedblleft jamming\\textquotedblright\\ points at volume fraction $\\phi_{\\rm J}^0 = \\phi_{\\rm rcp}$ (random close packing) for the low-stress lubricated state, and at $\\phi_{\\rm J} (\\mu) < \\phi_{\\rm J}^0$ for any nonzero $\\mu$ in the frictional state; a generalization provides the normal stress response as well as the shear stress. A flow state map of this material is developed based on the simulation results.

  5. Habitat connectivity and ecosystem productivity: implications from a simple model.

    Science.gov (United States)

    Cloern, J.E.

    2007-01-01

    The import of resources (food, nutrients) sustains biological production and food webs in resource-limited habitats. Resource export from donor habitats subsidizes production in recipient habitats, but the ecosystem-scale consequences of resource translocation are generally unknown. Here, I use a nutrient-phytoplankton-zooplankton model to show how dispersive connectivity between a shallow autotrophic habitat and a deep heterotrophic pelagic habitat can amplify overall system production in metazoan food webs. This result derives from the finite capacity of suspension feeders to capture and assimilate food particles: excess primary production in closed autotrophic habitats cannot be assimilated by consumers; however, if excess phytoplankton production is exported to food-limited heterotrophic habitats, it can be assimilated by zooplankton to support additional secondary production. Transport of regenerated nutrients from heterotrophic to autotrophic habitats sustains higher system primary production. These simulation results imply that the ecosystem-scale efficiency of nutrient transformation into metazoan biomass can be constrained by the rate of resource exchange across habitats and that it is optimized when the transport rate matches the growth rate of primary producers. Slower transport (i.e., reduced connectivity) leads to nutrient limitation of primary production in autotrophic habitats and food limitation of secondary production in heterotrophic habitats. Habitat fragmentation can therefore impose energetic constraints on the carrying capacity of aquatic ecosystems. The outcomes of ecosystem restoration through habitat creation will be determined by both functions provided by newly created aquatic habitats and the rates of hydraulic connectivity between them.

  6. A Simple Evacuation Modeling and Simulation Tool for First Responders

    Energy Technology Data Exchange (ETDEWEB)

    Koch, Daniel B [ORNL; Payne, Patricia W [ORNL

    2015-01-01

    Although modeling and simulation of mass evacuations during a natural or man-made disaster is an on-going and vigorous area of study, tool adoption by front-line first responders is uneven. Some of the factors that account for this situation include cost and complexity of the software. For several years, Oak Ridge National Laboratory has been actively developing the free Incident Management Preparedness and Coordination Toolkit (IMPACT) to address these issues. One of the components of IMPACT is a multi-agent simulation module for area-based and path-based evacuations. The user interface is designed so that anyone familiar with typical computer drawing tools can quickly author a geospatially-correct evacuation visualization suitable for table-top exercises. Since IMPACT is designed for use in the field where network communications may not be available, quick on-site evacuation alternatives can be evaluated to keep pace with a fluid threat situation. Realism is enhanced by incorporating collision avoidance into the simulation. Statistics are gathered as the simulation unfolds, including most importantly time-to-evacuate, to help first responders choose the best course of action.

  7. Takeover times for a simple model of network infection

    Science.gov (United States)

    Ottino-Löffler, Bertrand; Scott, Jacob G.; Strogatz, Steven H.

    2017-07-01

    We study a stochastic model of infection spreading on a network. At each time step a node is chosen at random, along with one of its neighbors. If the node is infected and the neighbor is susceptible, the neighbor becomes infected. How many time steps T does it take to completely infect a network of N nodes, starting from a single infected node? An analogy to the classic "coupon collector" problem of probability theory reveals that the takeover time T is dominated by extremal behavior, either when there are only a few infected nodes near the start of the process or a few susceptible nodes near the end. We show that for N ≫1 , the takeover time T is distributed as a Gumbel distribution for the star graph, as the convolution of two Gumbel distributions for a complete graph and an Erdős-Rényi random graph, as a normal for a one-dimensional ring and a two-dimensional lattice, and as a family of intermediate skewed distributions for d -dimensional lattices with d ≥3 (these distributions approach the convolution of two Gumbel distributions as d approaches infinity). Connections to evolutionary dynamics, cancer, incubation periods of infectious diseases, first-passage percolation, and other spreading phenomena in biology and physics are discussed.

  8. Use of Mesothelial Cells and Biological Matrices for Tissue Engineering of Simple Epithelium Surrogates

    Directory of Open Access Journals (Sweden)

    Christian Claude Lachaud

    2015-08-01

    Full Text Available Tissue engineering technologies have progressed rapidly through last decades resulting in the manufacture of quite complex bioartificial tissues with potential use for human organ and tissue regeneration. The manufacture of avascular monolayered tissues such as simple squamous epithelia was initiated a few decades ago and is attracting increasing interest. Their relative morphostructural simplicity makes of their biomimetization a goal, which is currently accessible. The mesothelium is a simple squamous epithelium in nature and is the monolayered tissue lining the walls of large coelomic cavities (peritoneal, pericardial and pleural and internal organs housed inside. Interestedly, mesothelial cells can be harvested in clinically relevant numbers from several anatomical sources and not less important, they also display high transdifferentiation capacities and are low immunogenic, characteristics, which endow these cells with therapeutic interest. Their combination with a suitable scaffold (biocompatible, degradable and non-immunogenic may allow the manufacture of tailored serosal membranes biomimetics with potential spanning a wide range of therapeutic applications, principally for the regeneration of simple squamous-like epithelia such as the visceral and parietal mesothelium vascular endothelium and corneal endothelium among others. Herein, we review recent research progresses in mesothelial cells biology and their clinical sources. We make a particular emphasis on reviewing the different types of biological scaffolds suitable for the manufacture of serosal mesothelial membranes biomimetics. Finally, we also review progresses made in mesothelial cells-based therapeutic applications and propose some possible future directions.

  9. A Simple Probabilistic Model for Estimating the Risk of Standard Air Dives

    National Research Council Canada - National Science Library

    Van Liew, H. D; Flynn, E. T

    2004-01-01

    .... Here we present a simple model, based on premises different from those used previously, to test whether long decompression times are necessary and to enable risk of decompression sickness (UCS...

  10. A rapid and simple procedure for the establishment of human normal and cancer renal primary cell cultures from surgical specimens.

    Directory of Open Access Journals (Sweden)

    Maria João Valente

    Full Text Available The kidney is a target organ for the toxicity of several xenobiotics and is also highly susceptible to the development of malignant tumors. In both cases, in vitro studies provide insight to cellular damage, and represent adequate models to study either the mechanisms underlying the toxic effects of several nephrotoxicants or therapeutic approaches in renal cancer. The development of efficient methods for the establishment of human normal and tumor renal cell models is hence crucial. In this study, a technically simple and rapid protocol for the isolation and culture of human proximal tubular epithelial cells and human renal tumor cells from surgical specimens is presented. Tumor and normal tissues were processed by using the same methodology, based on mechanical disaggregation of tissue followed by enzymatic digestion and cell purification by sequential sieving. The overall procedure takes roughly one hour. The resulting cell preparations have excellent viabilities and yield. Establishment of primary cultures from all specimens was achieved successfully. The origin of primary cultured cells was established through morphological evaluation. Normal cells purity was confirmed by immunofluorescent staining and reverse transcription-polymerase chain reaction analysis for expression of specific markers.

  11. Renal cell carcinoma presenting as a simple renal cyst: A case report.

    Science.gov (United States)

    Yu, Yanlan; Ma, Liang; Wang, Zhenghui; Zhang, Zhigen

    2017-04-01

    Cases of renal cell carcinoma (RCC) presenting as a simple cyst are extremely rare. We herein report the case of a patient with RCC diagnosed as a simple renal cyst preoperatively. A 39-year-old female patient presented with abdominal pain for 3 months. Ultrasonography and contrast-enhanced computed tomography revealed a simple cyst in the left kidney. The patient underwent laparoscopic decortication of the renal cyst. Biochemical analysis of the cystic fluid revealed unusually low levels of potassium, sodium, calcium and glucose, and the histological examination of the floor of the cyst indicated malignancy. Laparoscopic nephrectomy was performed 20 days later and the pathological examination confirmed the diagnosis of RCC of the clear cell type. At the 2-year follow-up, the patient remained well and recurrence-free on imaging. The aim of the present study was to emphasize the importance of recognizing that RCC may occur in what appears to be a simple renal cyst based on imaging results. Biochemical analysis of the cystic fluid may help identify the presence of malignancy.

  12. A Simple BODIPY-Based Viscosity Probe for Imaging of Cellular Viscosity in Live Cells.

    Science.gov (United States)

    Su, Dongdong; Teoh, Chai Lean; Gao, Nengyue; Xu, Qing-Hua; Chang, Young-Tae

    2016-08-31

    Intracellular viscosity is a fundamental physical parameter that indicates the functioning of cells. In this work, we developed a simple boron-dipyrromethene (BODIPY)-based probe, BTV, for cellular mitochondria viscosity imaging by coupling a simple BODIPY rotor with a mitochondria-targeting unit. The BTV exhibited a significant fluorescence intensity enhancement of more than 100-fold as the solvent viscosity increased. Also, the probe showed a direct linear relationship between the fluorescence lifetime and the media viscosity, which makes it possible to trace the change of the medium viscosity. Furthermore, it was demonstrated that BTV could achieve practical applicability in the monitoring of mitochondrial viscosity changes in live cells through fluorescence lifetime imaging microscopy (FLIM).

  13. The Development Study of a Medical Ethics Education Program by Using Simple ISD Model.

    Science.gov (United States)

    Kim, Young Jon; Yoo, Hyoo Hyun; Joo, Chan Uhng

    2011-09-01

    Simple instructional systems design (ISD) model is based on a fast development, usability test, and continuos feedback, which are necessary for educational program development in medical school. This study aims to figure out the usability of Simple ISD model for a medical ethics education program by describing a developmental details of each phase and its evaluation results. Research has been conducted in two steps. First, while researchers participated in the program development by using Simple ISD model, we collected empirical data of each development activities. Second, the developed program was evaluated by students' web-based usability test, a 8-students' focus group interview and 5 faculty members' individual interviews in 4 domains; learning contents, instructional methods and strategies, achievement evaluation, and self-evaluation. Following the circular process of analysis, design, development, and usability test of Simple ISD model, a 10-week medical ethics program covering 9 instructional topics was developed. The average points of response on the developed medical ethics program in 2008 and 2009 are increased from 3.96 to 4.59 and 4.41, respectively. The prospects and limitations of the program are discussed. From a development study of the medical ethics program by using Simple ISD model, we could implement a more usable medical ethics program, and found 4 different usability of the Simple ISD model; the rapid development of educational program, program improvement by continuous feedback, faculty members' engagement in instructional design, and professional development of the faculty members.

  14. Models of growth for system of cities : Back to the simple

    OpenAIRE

    RAIMBAULT , Juste

    2016-01-01

    Understanding growth patterns in complex systems of cities through modeling is an intensive branch of quantitative geography. Complex agent-based models have been recently provided promising results by multi-modeling and intensive computation for pattern discovery and calibration. However simple interaction-based extensions of seminal models of growth (such as the Gibrat model) have not yet been tested and calibrated against real datasets. We propose a spatial model of urban growth extending ...

  15. Improved Analysis of Earth System Models and Observations using Simple Climate Models

    Science.gov (United States)

    Nadiga, B. T.; Urban, N. M.

    2016-12-01

    Earth system models (ESM) are the most comprehensive tools we have to study climate change and develop climate projections. However, the computational infrastructure required and the cost incurred in running such ESMs precludes direct use of such models in conjunction with a wide variety of tools that can further our understanding of climate. Here we are referring to tools that range from dynamical systems tools that give insight into underlying flow structure and topology to tools that come from various applied mathematical and statistical techniques and are central to quantifying stability, sensitivity, uncertainty and predictability to machine learning tools that are now being rapidly developed or improved. Our approach to facilitate the use of such models is to analyze output of ESM experiments (cf. CMIP) using a range of simpler models that consider integral balances of important quantities such as mass and/or energy in a Bayesian framework.We highlight the use of this approach in the context of the uptake of heat by the world oceans in the ongoing global warming. Indeed, since in excess of 90% of the anomalous radiative forcing due greenhouse gas emissions is sequestered in the world oceans, the nature of ocean heat uptake crucially determines the surface warming that is realized (cf. climate sensitivity). Nevertheless, ESMs themselves are never run long enough to directly assess climate sensitivity. So, we consider a range of models based on integral balances--balances that have to be realized in all first-principles based models of the climate system including the most detailed state-of-the art climate simulations. The models range from simple models of energy balance to those that consider dynamically important ocean processes such as the conveyor-belt circulation (Meridional Overturning Circulation, MOC), North Atlantic Deep Water (NADW) formation, Antarctic Circumpolar Current (ACC) and eddy mixing. Results from Bayesian analysis of such models using

  16. A first-approximation simple dynamic growth model for forest teak ...

    African Journals Online (AJOL)

    A biologically consistent whole-stand growth model is presented, which uses the state-space approach for modelling rates of change of dominant height, stand density and stand basal area. A simple model containing few free parameters performed well and is particularly well suited to situations where available data are ...

  17. Simple model for daily evaporation from fallow tilled soil under spring conditions in a temperate climate.

    NARCIS (Netherlands)

    Boesten, J.J.T.I.; Stroosnijder, L.

    1986-01-01

    A simple parametric model is presented to estimate daily evaporation from fallow tilled soil under spring conditions in a temperate climate. In this model, cumulative actual evaporation during a drying cycle is directly proportional to the square root of cumulative potential evaporation. The model

  18. A simple procedure to model water level fluctuations in partially inundated wetlands

    NARCIS (Netherlands)

    Spieksma, JFM; Schouwenaars, JM

    When modelling groundwater behaviour in wetlands, there are specific problems related to the presence of open water in small-sized mosaic patterns. A simple quasi two-dimensional model to predict water level fluctuations in partially inundated wetlands is presented. In this model, the ratio between

  19. A simple model of group selection that cannot be analyzed with inclusive fitness

    NARCIS (Netherlands)

    van Veelen, M.; Luo, S.; Simon, B.

    2014-01-01

    A widespread claim in evolutionary theory is that every group selection model can be recast in terms of inclusive fitness. Although there are interesting classes of group selection models for which this is possible, we show that it is not true in general. With a simple set of group selection models,

  20. Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamics

    Directory of Open Access Journals (Sweden)

    Witten Tarynn M

    2010-06-01

    Full Text Available Abstract Background In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is considered from both the logistic and the Gompertzian case, while normal cell growth of fibroblasts (WI-38 human diploid fibroblasts is considered as logistic only. Results We demonstrate, in a simple approach, how the interdependency of different cell types in a tumor, together with specifications of for treatment, can lead to different evolutionary patterns for normal and tumor cells during a course of therapy. Conclusions These results have significance for understanding appropriate pharmacotherapy for elderly patients who are also undergoing chemotherapy.

  1. Multi-Criteria Decision Making For Determining A Simple Model of Supplier Selection

    Science.gov (United States)

    Harwati

    2017-06-01

    Supplier selection is a decision with many criteria. Supplier selection model usually involves more than five main criteria and more than 10 sub-criteria. In fact many model includes more than 20 criteria. Too many criteria involved in supplier selection models sometimes make it difficult to apply in many companies. This research focuses on designing supplier selection that easy and simple to be applied in the company. Analytical Hierarchy Process (AHP) is used to weighting criteria. The analysis results there are four criteria that are easy and simple can be used to select suppliers: Price (weight 0.4) shipment (weight 0.3), quality (weight 0.2) and services (weight 0.1). A real case simulation shows that simple model provides the same decision with a more complex model.

  2. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture.

    Science.gov (United States)

    DeQuach, Jessica A; Mezzano, Valeria; Miglani, Amar; Lange, Stephan; Keller, Gordon M; Sheikh, Farah; Christman, Karen L

    2010-09-27

    The native extracellular matrix (ECM) consists of a highly complex, tissue-specific network of proteins and polysaccharides, which help regulate many cellular functions. Despite the complex nature of the ECM, in vitro cell-based studies traditionally assess cell behavior on single ECM component substrates, which do not adequately mimic the in vivo extracellular milieu. We present a simple approach for developing naturally derived ECM coatings for cell culture that provide important tissue-specific cues unlike traditional cell culture coatings, thereby enabling the maturation of committed C2C12 skeletal myoblast progenitors and human embryonic stem cells differentiated into cardiomyocytes. Here we show that natural muscle-specific coatings can (i) be derived from decellularized, solubilized adult porcine muscle, (ii) contain a complex mixture of ECM components including polysaccharides, (iii) adsorb onto tissue culture plastic and (iv) promote cell maturation of committed muscle progenitor and stem cells. This versatile method can create tissue-specific ECM coatings, which offer a promising platform for cell culture to more closely mimic the mature in vivo ECM microenvironment.

  3. A Simple Alkaline Method for Decellularizing Human Amniotic Membrane for Cell Culture

    Science.gov (United States)

    Saghizadeh, Mehrnoosh; Winkler, Michael A.; Kramerov, Andrei A.; Hemmati, David M.; Ghiam, Chantelle A.; Dimitrijevich, Slobodan D.; Sareen, Dhruv; Ornelas, Loren; Ghiasi, Homayon; Brunken, William J.; Maguen, Ezra; Rabinowitz, Yaron S.; Svendsen, Clive N.; Jirsova, Katerina; Ljubimov, Alexander V.

    2013-01-01

    Human amniotic membrane is a standard substratum used to culture limbal epithelial stem cells for transplantation to patients with limbal stem cell deficiency. Various methods were developed to decellularize amniotic membrane, because denuded membrane is poorly immunogenic and better supports repopulation by dissociated limbal epithelial cells. Amniotic membrane denuding usually involves treatment with EDTA and/or proteolytic enzymes; in many cases additional mechanical scraping is required. Although ensuring limbal cell proliferation, these methods are not standardized, require relatively long treatment times and can result in membrane damage. We propose to use 0.5 M NaOH to reliably remove amniotic cells from the membrane. This method was used before to lyse cells for DNA isolation and radioactivity counting. Gently rubbing a cotton swab soaked in NaOH over the epithelial side of amniotic membrane leads to nearly complete and easy removal of adherent cells in less than a minute. The denuded membrane is subsequently washed in a neutral buffer. Cell removal was more thorough and uniform than with EDTA, or EDTA plus mechanical scraping with an electric toothbrush, or n-heptanol plus EDTA treatment. NaOH-denuded amniotic membrane did not show any perforations compared with mechanical or thermolysin denuding, and showed excellent preservation of immunoreactivity for major basement membrane components including laminin α2, γ1-γ3 chains, α1/α2 and α6 type IV collagen chains, fibronectin, nidogen-2, and perlecan. Sodium hydroxide treatment was efficient with fresh or cryopreserved (10% dimethyl sulfoxide or 50% glycerol) amniotic membrane. The latter method is a common way of membrane storage for subsequent grafting in the European Union. NaOH-denuded amniotic membrane supported growth of human limbal epithelial cells, immortalized corneal epithelial cells, and induced pluripotent stem cells. This simple, fast and reliable method can be used to standardize

  4. A simple alkaline method for decellularizing human amniotic membrane for cell culture.

    Directory of Open Access Journals (Sweden)

    Mehrnoosh Saghizadeh

    Full Text Available Human amniotic membrane is a standard substratum used to culture limbal epithelial stem cells for transplantation to patients with limbal stem cell deficiency. Various methods were developed to decellularize amniotic membrane, because denuded membrane is poorly immunogenic and better supports repopulation by dissociated limbal epithelial cells. Amniotic membrane denuding usually involves treatment with EDTA and/or proteolytic enzymes; in many cases additional mechanical scraping is required. Although ensuring limbal cell proliferation, these methods are not standardized, require relatively long treatment times and can result in membrane damage. We propose to use 0.5 M NaOH to reliably remove amniotic cells from the membrane. This method was used before to lyse cells for DNA isolation and radioactivity counting. Gently rubbing a cotton swab soaked in NaOH over the epithelial side of amniotic membrane leads to nearly complete and easy removal of adherent cells in less than a minute. The denuded membrane is subsequently washed in a neutral buffer. Cell removal was more thorough and uniform than with EDTA, or EDTA plus mechanical scraping with an electric toothbrush, or n-heptanol plus EDTA treatment. NaOH-denuded amniotic membrane did not show any perforations compared with mechanical or thermolysin denuding, and showed excellent preservation of immunoreactivity for major basement membrane components including laminin α2, γ1-γ3 chains, α1/α2 and α6 type IV collagen chains, fibronectin, nidogen-2, and perlecan. Sodium hydroxide treatment was efficient with fresh or cryopreserved (10% dimethyl sulfoxide or 50% glycerol amniotic membrane. The latter method is a common way of membrane storage for subsequent grafting in the European Union. NaOH-denuded amniotic membrane supported growth of human limbal epithelial cells, immortalized corneal epithelial cells, and induced pluripotent stem cells. This simple, fast and reliable method can be used to

  5. A Simple Mathematical Model for Standard Model of Elementary Particles and Extension Thereof

    Science.gov (United States)

    Sinha, Ashok

    2016-03-01

    An algebraically (and geometrically) simple model representing the masses of the elementary particles in terms of the interaction (strong, weak, electromagnetic) constants is developed, including the Higgs bosons. The predicted Higgs boson mass is identical to that discovered by LHC experimental programs; while possibility of additional Higgs bosons (and their masses) is indicated. The model can be analyzed to explain and resolve many puzzles of particle physics and cosmology including the neutrino masses and mixing; origin of the proton mass and the mass-difference between the proton and the neutron; the big bang and cosmological Inflation; the Hubble expansion; etc. A novel interpretation of the model in terms of quaternion and rotation in the six-dimensional space of the elementary particle interaction-space - or, equivalently, in six-dimensional spacetime - is presented. Interrelations among particle masses are derived theoretically. A new approach for defining the interaction parameters leading to an elegant and symmetrical diagram is delineated. Generalization of the model to include supersymmetry is illustrated without recourse to complex mathematical formulation and free from any ambiguity. This Abstract represents some results of the Author's Independent Theoretical Research in Particle Physics, with possible connection to the Superstring Theory. However, only very elementary mathematics and physics is used in my presentation.

  6. Spectral reflectance of solar light from dirty snow: a simple theoretical model and its validation

    OpenAIRE

    A. Kokhanovsky

    2013-01-01

    A simple analytical equation for the snow albedo as the function of snow grain size, soot concentration, and soot mass absorption coefficient is presented. This simple equation can be used in climate models to assess the influence of snow pollution on snow albedo. It is shown that the squared logarithm of the albedo (in the visible) is directly proportional to the soot concentration. A new method of the determination of the soot mass absorption coefficient in snow is proposed. The equations d...

  7. Modeling Impact of Urbanization in US Cities Using Simple Biosphere Model SiB2

    Science.gov (United States)

    Zhang, Ping; Bounoua, Lahouari; Thome, Kurtis; Wolfe, Robert

    2016-01-01

    We combine Landsat- and the Moderate Resolution Imaging Spectroradiometer (MODIS)-based products, as well as climate drivers from Phase 2 of the North American Land Data Assimilation System (NLDAS-2) in a Simple Biosphere land surface model (SiB2) to assess the impact of urbanization in continental USA (excluding Alaska and Hawaii). More than 300 cities and their surrounding suburban and rural areas are defined in this study to characterize the impact of urbanization on surface climate including surface energy, carbon budget, and water balance. These analyses reveal an uneven impact of urbanization across the continent that should inform upon policy options for improving urban growth including heat mitigation and energy use, carbon sequestration and flood prevention.

  8. On the nuclear energy generation rate in a simple analytic stellar model

    International Nuclear Information System (INIS)

    Haubold, H.J.

    1985-01-01

    For a shperically symmetric star in quasi-static equilibrium a simple analytic stellar model is presented. The common technique of integration theory of special functions for treating a special solution of the equations of stellar structure is described. As an example the sun can be considered as a fluid in hydrostatic equilibrium. The total net rate of nuclear energy generation, which is equal to the luminosity of the star, is evaluated analytically for a linear density distribution assumed for a simple stellar model. For several analytic representations of the nuclear energy generation rate the luminosity function is evaluated for the presented stellar model in closed form

  9. Evaluation of a Centrifuged Double Y-Shape Microfluidic Platform for Simple Continuous Cell Environment Exchange

    Directory of Open Access Journals (Sweden)

    Akihiro Hattori

    2012-01-01

    Full Text Available We have demonstrated the efficacy of a microfluidic medium exchange method for single cells using passive centrifugal force of a rotating microfluidic-chip based platform. At the boundary of two laminar flows at the gathering area of two microfluidic pathways in a Y-shape, the cells were successfully transported from one laminar flow to the other, without mixing the two microfluidic mediums of the two laminar flows during cell transportation, within 5 s with 1 g (150 rpm to 36.3 g (900 rpm acceleration, with 93.5% efficiency. The results indicate that this is one of the most simple and precise tools for exchanging medium in the shortest amount of time.

  10. A Sound Processor for Cochlear Implant Using a Simple Dual Path Nonlinear Model of Basilar Membrane

    OpenAIRE

    Kim, Kyung Hwan; Choi, Sung Jin; Kim, Jin Ho

    2013-01-01

    We propose a new active nonlinear model of the frequency response of the basilar membrane in biological cochlea called the simple dual path nonlinear (SDPN) model and a novel sound processing strategy for cochlear implants (CIs) based upon this model. The SDPN model was developed to utilize the advantages of the level-dependent frequency response characteristics of the basilar membrane for robust formant representation under noisy conditions. In comparison to the dual resonance nonlinear mode...

  11. Surface pressure model for simple delta wings at high angles of attack

    Indian Academy of Sciences (India)

    A new aerodynamic modelling approach is proposed for the longitudinal static characteristics of a simple delta wing. It captures the static variation of normal force and pitching moment characteristics throughout the angle of attack range. The pressure model is based on parametrizing the surface pressure distribution on a ...

  12. A simple model for chiral amplification in the aminoalcohol-catalyzed reaction of aldehydes with dialkylzinc

    Directory of Open Access Journals (Sweden)

    IVAN GUTMAN

    1999-08-01

    Full Text Available A simple explanation is offered for the recently discovered chiral amplification in the alkylation reaction of benzaldehyde by means of dialkylzinc, catalyzed by (dimethylaminoisoborneol. The model presentd is similar to, yet somewhat simpler than, the model put forward by Noyori et al.

  13. Modelling the phonotactic structure of natural language words with simple recurrent networks

    NARCIS (Netherlands)

    Stoianov, [No Value; Nerbonne, J; Bouma, H; Coppen, PA; vanHalteren, H; Teunissen, L

    1998-01-01

    Simple Recurrent Networks (SRN) are Neural Network (connectionist) models able to process natural language. Phonotactics concerns the order of symbols in words. We continued an earlier unsuccessful trial to model the phonotactics of Dutch words with SRNs. In order to overcome the previously reported

  14. A Simple Model to Teach Business Cycle Macroeconomics for Emerging Market and Developing Economies

    Science.gov (United States)

    Duncan, Roberto

    2015-01-01

    The canonical neoclassical model is insufficient to understand business cycle fluctuations in emerging market and developing economies. The author reformulates the model proposed by Aguiar and Gopinath (2007) in a simple setting that can be used to teach business cycle macroeconomics for emerging market and developing economies at the…

  15. A simple model for dynamic small-angle X-ray diffraction in colloidal crystals

    NARCIS (Netherlands)

    de Beer, A.G.F.; Petukhov, A.V.

    2007-01-01

    A simple model is presented that allows calculation of the small-angle X-ray diffraction patterns of perfect colloidal crystals. The model is based on the Wentzel–Kramers–Brillouin approximation and permits a straightforward evaluation of multibeam interactions. Results are illustrated by several

  16. Simple non-Markovian microscopic models for the depolarizing channel of a single qubit

    International Nuclear Information System (INIS)

    Fonseca Romero, K M; Lo Franco, R

    2012-01-01

    The archetypal one-qubit noisy channels - depolarizing, phase-damping and amplitude-damping channels - describe both Markovian and non-Markovian evolution. Simple microscopic models for the depolarizing channel, both classical and quantum, are considered. Microscopic models that describe phase-damping and amplitude-damping channels are briefly reviewed.

  17. A Simple Model for the Vertical Transport of Reactive Species in the Convective Atmospheric Boundary Layer

    DEFF Research Database (Denmark)

    Kristensen, Leif; Lenschow, Donald H.; Gurarie, David

    2010-01-01

    We have developed a simple, steady-state, one-dimensional second-order closure model to obtain continuous profiles of turbulent fluxes and mean concentrations of non-conserved scalars in a convective boundary layer without shear. As a basic tool we first set up a model for conserved species with ...

  18. A simple atmospheric boundary layer model applied to large eddy simulations of wind turbine wakes

    DEFF Research Database (Denmark)

    Troldborg, Niels; Sørensen, Jens Nørkær; Mikkelsen, Robert Flemming

    2014-01-01

    A simple model for including the influence of the atmospheric boundary layer in connection with large eddy simulations of wind turbine wakes is presented and validated by comparing computed results with measurements as well as with direct numerical simulations. The model is based on an immersed...

  19. A simple constitutive model for a polymer flow near a polymer-grafted wall

    NARCIS (Netherlands)

    Stepanyan, R.; Slot, J.J.M.; Molenaar, J.; Tchesnokov, M.A.

    2005-01-01

    A simple constitutive model is proposed to describe a polymer flow near a polymer-grafted wall. The model is based on a generalization of the Rolie-Poly equation [A. E. Likhtman and R. S. Graham, J. Non-Newton. Fluid Mech. 114, 1¿12 (2003)] to a "bulk+wall" system combined with a microscopic picture

  20. How Long is my Toilet Roll?--A Simple Exercise in Mathematical Modelling

    Science.gov (United States)

    Johnston, Peter R.

    2013-01-01

    The simple question of how much paper is left on my toilet roll is studied from a mathematical modelling perspective. As is typical with applied mathematics, models of increasing complexity are introduced and solved. Solutions produced at each step are compared with the solution from the previous step. This process exposes students to the typical…

  1. Simple metal model for predicting uptake and chemical processes in sewage-fed aquaculture ecosystem

    DEFF Research Database (Denmark)

    Azanu, David; Jorgensen, Sven Erik; Darko, Godfred

    2016-01-01

    % was the best, which is also in accordance to the fish growth. The ratio of fish food was also calibrated to be 70% due to a food chain in the water and 30% due to a food chain in the sediment. This gave the lowest uncertainty of the model. The simple metal model was working acceptably well for Pb, Cu and Cd...... regression with an R2 value of 0.9 indicating that a good agreement between the model predictions and the experimental measurements. The finding suggests that the simple metal model is an accurate and useful for predicting uptake and chemical processes in ecosystem.......This paper shows how a model can be used as an experimental tool to assess the processes in aqua chemistry that should be included in the model. The STELLA software was used to study the uptake of Cd, Pb, Cr, Cu and Hg from sewage-fed aquaculture. Model calibration revealed that feeding rate of 15...

  2. A simple model for radial expansion reactivity in LMRs [liquid metal reactors

    International Nuclear Information System (INIS)

    Cheng, H.S.; Van Tuyle, G.J.

    1988-01-01

    Presented in this report is a simple analytical model developed for evaluating the radial expansion reactivity in small modular liquid metal reactors (LMRs). The present model is based on a non-leakage representation of the effective neutron multiplication factor. The resultant analytical expression for the radial expansion reactivity is simple and can be used directly in a system code for safety analyses. Applications of the present model to PRISM and SAFR resulted in a good agreement with the values reported by vendors. This agreement establishes that the large negative reactivity insertion resulting from LMR core radial expansion can be confirmed using a simple analytical approach, and thus is important in the current effort to evaluate the reactor inherent feedbacks for the PRISM and SAFR designs

  3. Female germline stem cell niches of earwigs are structurally simple and different from those of Drosophila melanogaster.

    Science.gov (United States)

    Tworzydlo, Waclaw; Kloc, Malgorzata; Bilinski, Szczepan M

    2010-05-01

    Stem cells function in niches, which consist of somatic cells that control the stem cells' self-renewal, proliferation, and differentiation. Drosophila ovary germline niche consists of the terminal filament (TF) cells, cap cells, and escort stem cells; signaling from the TF cells and the cap cells is essential for maintenance of germline stem cells (GSCs). Here, we show that in the earwig Opisthocosmia silvestris, the female GSC niche is morphologically simple and consist of the TF cells and several structurally uniform escort cells. The most posterior cell of the TF (the basal cell of the TF) differs from remaining TF cells and is separated from the anterior region of the germarium by the processes of the escort cells, and consequently, does not contact the GSCs directly. We also show that between somatic cells of earwig niche argosome-like vesicles and cytoneme-like extensions are present. (c) 2009 Wiley-Liss, Inc.

  4. A phenomenological model for the structure-composition relationship of the high Tc cuprates based on simple chemical principles

    International Nuclear Information System (INIS)

    Alarco, J.A.; Talbot, P.C.

    2012-01-01

    A simple phenomenological model for the relationship between structure and composition of the high Tc cuprates is presented. The model is based on two simple crystal chemistry principles: unit cell doping and charge balance within unit cells. These principles are inspired by key experimental observations of how the materials accommodate large deviations from stoichiometry. Consistent explanations for significant HTSC properties can be explained without any additional assumptions while retaining valuable insight for geometric interpretation. Combining these two chemical principles with a review of Crystal Field Theory (CFT) or Ligand Field Theory (LFT), it becomes clear that the two oxidation states in the conduction planes (typically d 8 and d 9 ) belong to the most strongly divergent d-levels as a function of deformation from regular octahedral coordination. This observation offers a link to a range of coupling effects relating vibrations and spin waves through application of Hund’s rules. An indication of this model’s capacity to predict physical properties for HTSC is provided and will be elaborated in subsequent publications. Simple criteria for the relationship between structure and composition in HTSC systems may guide chemical syntheses within new material systems.

  5. Spin glass model for cell reprogramming

    Science.gov (United States)

    Pusuluri, Sai Teja; Castillo, Horacio E.

    2014-03-01

    Recent experiments show that differentiated cells can be reprogrammed to become pluripotent stem cells. The possible cell fates can be modeled as attractors in a dynamical system, the ``epigenetic landscape.'' Both cellular differentiation and reprogramming can be described in the landscape picture as motion from one attractor state to another attractor state. We use a simple model based on spin glass theory that can construct a simulated epigenetic landscape starting from the experimental genomic data. We modify the model to incorporate experimental reprogramming protocols. Our simulations successfully reproduce several reprogramming experiments. We probe the robustness of the results against random changes in the model, explore the importance of asymmetric interactions between transcription factors and study the importance of histone modification errors in reprogramming.

  6. Modeling Surface Climate in US Cities Using Simple Biosphere Model Sib2

    Science.gov (United States)

    Zhang, Ping; Bounoua, Lahouari; Thome, Kurtis; Wolfe, Robert; Imhoff, Marc

    2015-01-01

    We combine Landsat- and the Moderate Resolution Imaging Spectroradiometer (MODIS)-based products in the Simple Biosphere model (SiB2) to assess the effects of urbanized land on the continental US (CONUS) surface climate. Using National Land Cover Database (NLCD) Impervious Surface Area (ISA), we define more than 300 urban settlements and their surrounding suburban and rural areas over the CONUS. The SiB2 modeled Gross Primary Production (GPP) over the CONUS of 7.10 PgC (1 PgC= 10(exp 15) grams of Carbon) is comparable to the MODIS improved GPP of 6.29 PgC. At state level, SiB2 GPP is highly correlated with MODIS GPP with a correlation coefficient of 0.94. An increasing horizontal GPP gradient is shown from the urban out to the rural area, with, on average, rural areas fixing 30% more GPP than urbans. Cities built in forested biomes have stronger UHI magnitude than those built in short vegetation with low biomass. Mediterranean climate cities have a stronger UHI in wet season than dry season. Our results also show that for urban areas built within forests, 39% of the precipitation is discharged as surface runoff during summer versus 23% in rural areas.

  7. Identification of Super Phenix steam generator by a simple polynomial model

    International Nuclear Information System (INIS)

    Rousseau, I.

    1981-01-01

    This note suggests a method of identification for the steam generator of the Super-Phenix fast neutron power plant for simple polynomial models. This approach is justified in the selection of the adaptive control. The identification algorithms presented will be applied to multivariable input-output behaviours. The results obtained with the representation in self-regressive form and by simple polynomial models will be compared and the effect of perturbations on the output signal will be tested, in order to select a good identification algorithm for multivariable adaptive regulation [fr

  8. A Mathematical Model of a Simple Amplifier Using a Ferroelectric Transistor

    Science.gov (United States)

    Sayyah, Rana; Hunt, Mitchell; MacLeod, Todd C.; Ho, Fat D.

    2009-01-01

    This paper presents a mathematical model characterizing the behavior of a simple amplifier using a FeFET. The model is based on empirical data and incorporates several variables that affect the output, including frequency, load resistance, and gate-to-source voltage. Since the amplifier is the basis of many circuit configurations, a mathematical model that describes the behavior of a FeFET-based amplifier will help in the integration of FeFETs into many other circuits.

  9. A Simple Model for Complex Fabrication of MEMS based Pressure Sensor: A Challenging Approach

    Directory of Open Access Journals (Sweden)

    Himani SHARMA

    2010-08-01

    Full Text Available In this paper we have presented the simple model for complex fabrication of MEMS based absolute micro pressure sensor. This kind of modeling is extremely useful for determining its complexity in fabrication steps and provides complete information about process sequence to be followed during manufacturing. Therefore, the need for test iteration decreases and cost, time can be reduced significantly. By using DevEdit tool (part of SILVACO tool, a behavioral model of pressure sensor have been presented and implemented.

  10. How long is my toilet roll? - a simple exercise in mathematical modelling

    Science.gov (United States)

    Johnston, Peter R.

    2013-09-01

    The simple question of how much paper is left on my toilet roll is studied from a mathematical modelling perspective. As is typical with applied mathematics, models of increasing complexity are introduced and solved. Solutions produced at each step are compared with the solution from the previous step. This process exposes students to the typical stages of mathematical modelling via an example from everyday life. Two activities are suggested for students to complete, as well as several extensions to stimulate class discussion.

  11. A simple model for super critical fluid extraction of bio oils from biomass

    International Nuclear Information System (INIS)

    Patel, Rajesh N.; Bandyopadhyay, Santanu; Ganesh, Anuradda

    2011-01-01

    A simple mathematical model to characterize the supercritical extraction process has been proposed in this paper. This model is primarily based on two mass transfer mechanisms: solubility and diffusion. The model assumes two districts mode of extraction: initial constant rate extraction that is controlled by solubility and falling rate extraction that is controlled by diffusivity. Effects of extraction parameters such as pressure and temperature on the extraction of oil have also been studied. The proposed model, when compared with existing models, shows better agreement with the experimental results. The proposed model developed has been applied for both high initial oil content material (cashew nut shells) and low initial oil content material (black pepper).

  12. WEB-DHM: A distributed biosphere hydrological model developed by coupling a simple biosphere scheme with a hillslope hydrological model

    Science.gov (United States)

    The coupling of land surface models and hydrological models potentially improves the land surface representation, benefiting both the streamflow prediction capabilities as well as providing improved estimates of water and energy fluxes into the atmosphere. In this study, the simple biosphere model 2...

  13. Simple models of district heating systems for load and demand side management and operational optimisation; Simple modeller for fjernvarmesystemer med henblik pae belastningsudjaevning og driftsoptimering

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, B. [Technical Univ. of Denmark, Dept. of Mechanical Engineering, Kgs. Lyngby (Denmark); Larsen, H.V. [Risoe National Lab., System Analysis Dept., Roskilde (DK)

    2004-12-01

    The purpose of this research project has been to further develop and test simple (aggregated) models of district heating (DH) systems for simulation and operational optimization, and to investigate the influence of Load Management and Demand Side Management (DMS) on the total operational costs. The work is based on physical-mathematical modelling and simulation of DH systems, and is a continuation of previous EFP-96 work. In the present EFP-2001 project the goals have been to improve the Danish method of aggregation by addressing the problem of aggregation of pressure losses, and to test the methods on a much larger data set than in the EFP-1996 project. In order to verify the models it is crucial to have good data at disposal. Full information on the heat loads and temperatures not only at the DH plant but also at every consumer (building) is needed, and therefore only a few DH systems in Denmark can supply such data. (BA)

  14. One-Step Facile Synthesis of a Simple Hole Transport Material for Efficient Perovskite Solar Cells

    KAUST Repository

    Chen, Hu

    2016-04-04

    A hole transporting material was designed for use in perovskite solar cells, with a facile one-step synthesis from inexpensive, com-mercially available reagents. The molecule comprises a central fluorinated phenyl core with pendant aryl amines, namely, 3,6-difluoro-N1,N1,N2,N2,N4,N4,N5,N5-octakis(4-methoxyphenyl)benzene-1,2,4,5-tetraamine (DFTAB). A power conversion efficiency of up to 10.4% was achieved in a mesoporous perovskite device architecture. The merits of a simple and potentially low cost syn-thetic route as well as promising performance in perovskite devices, encourages further development of this materials class as new low-cost hole transporting materials for the scale up of perovskite solar cells.

  15. A simple microfluidic dispenser for single-microparticle and cell samples.

    Science.gov (United States)

    Kasukurti, A; Eggleton, C D; Desai, S A; Disharoon, D I; Marr, D W M

    2014-12-21

    Non-destructive isolation of single-cells has become an important need for many biology research laboratories; however, there is a lack of easily employed and inexpensive tools. Here, we present a single-particle sample delivery approach fabricated from simple, economical components that may address this need. In this, we employ unique flow and timing strategies to bridge the significant force and length scale differences inherent in transitioning from single particle isolation to delivery. Demonstrating this approach, we use an optical trap to isolate individual microparticles and red blood cells that are dispensed within separate 50 μl droplets off a microfluidic chip for collection into microscope slides or microtiter plates.

  16. A Simple and Efficient MPPT Method for Low-Power PV Cells

    Directory of Open Access Journals (Sweden)

    Maria Teresa Penella

    2014-01-01

    Full Text Available Small-size PV cells have been used to power sensor nodes. These devices present limited computing resources and so low complexity methods have been used in order to extract the maximum power from the PV cells. Among them, the fractional open circuit voltage (FOCV method has been widely proposed, where the maximum power point of the PV cell is estimated from a fraction of its open circuit voltage. Here, we show a generalization of the FOCV method that keeps its inherent simplicity and improves the tracking efficiency. First, a single-diode model for PV cells was used to compute the tracking efficiency versus irradiance. Computations were carried out for different values of the parameters involved in the PV cell model. The proposed approach clearly outperformed the FOCV method, specially at low irradiance, which is significant for powering sensor nodes. Experimental tests performed with a 500 mW PV panel agreed with these results.

  17. QSAR modelling using combined simple competitive learning networks and RBF neural networks.

    Science.gov (United States)

    Sheikhpour, R; Sarram, M A; Rezaeian, M; Sheikhpour, E

    2018-04-01

    The aim of this study was to propose a QSAR modelling approach based on the combination of simple competitive learning (SCL) networks with radial basis function (RBF) neural networks for predicting the biological activity of chemical compounds. The proposed QSAR method consisted of two phases. In the first phase, an SCL network was applied to determine the centres of an RBF neural network. In the second phase, the RBF neural network was used to predict the biological activity of various phenols and Rho kinase (ROCK) inhibitors. The predictive ability of the proposed QSAR models was evaluated and compared with other QSAR models using external validation. The results of this study showed that the proposed QSAR modelling approach leads to better performances than other models in predicting the biological activity of chemical compounds. This indicated the efficiency of simple competitive learning networks in determining the centres of RBF neural networks.

  18. Comparison of blood biochemics between acute myocardial infarction models with blood stasis and simple acute myocardial infarction models in rats

    International Nuclear Information System (INIS)

    Qu Shaochun; Yu Xiaofeng; Wang Jia; Zhou Jinying; Xie Haolin; Sui Dayun

    2010-01-01

    Objective: To construct the acute myocardial infarction models in rats with blood stasis and study the difference on blood biochemics between the acute myocardial infarction models with blood stasis and the simple acute myocardial infarction models. Methods: Wistar rats were randomly divided into control group, acute blood stasis model group, acute myocardial infarction sham operation group, acute myocardial infarction model group and of acute myocardial infarction model with blood stasis group. The acute myocardial infarction models under the status of the acute blood stasis in rats were set up. The serum malondialdehyde (MDA), nitric oxide (NO), free fatty acid (FFA), tumor necrosis factor-α (TNF-α) levels were detected, the activities of serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the levels of prostacycline (PGI2), thromboxane A 2 (TXA 2 ) and endothelin (ET) in plasma were determined. Results: There were not obvious differences in MDA, SOD, GSH-Px and FFA between the acute myocardial infarction models with blood stasis in rats and the simple acute myocardial infarction models (P 2 and NO, and the increase extents of TXA 2 , ET and TNF-α in the acute myocardial infarction models in rats with blood stasis were higher than those in the simple acute myocardial infarction models (P 2 and NO, are significant when the acute myocardial infarction models in rats with blood stasis and the simple acute myocardial infarction models are compared. The results show that it is defective to evaluate pharmacodynamics of traditional Chinese drug with only simple acute myocardial infarction models. (authors)

  19. Simple computational modeling for human extracorporeal irradiation using the BNCT facility of the RA-3 Reactor

    International Nuclear Information System (INIS)

    Farias, Ruben; Gonzalez, S.J.; Bellino, A.; Sztenjberg, M.; Pinto, J.; Thorp, Silvia I.; Gadan, M.; Pozzi, Emiliano; Schwint, Amanda E.; Heber, Elisa M.; Trivillin, V.A.; Zarza, Leandro G.; Estryk, Guillermo; Miller, M.; Bortolussi, S.; Soto, M.S.; Nigg, D.W.

    2009-01-01

    We present a simple computational model of the reactor RA-3 developed using Monte Carlo transport code MCNP. The model parameters are adjusted in order to reproduce experimental measured points in air and the source validation is performed in an acrylic phantom. Performance analysis is carried out using computational models of animal extracorporeal irradiation in liver and lung. Analysis is also performed inside a neutron shielded receptacle use for the irradiation of rats with a model of hepatic metastases.The computational model reproduces the experimental behavior in all the analyzed cases with a maximum difference of 10 percent. (author)

  20. Reheating via Gravitational Particle Production in Simple Models of Quintessence or ΛCDM Inflation

    Directory of Open Access Journals (Sweden)

    Jaume de Haro

    2017-11-01

    Full Text Available We have tested some simple Λ CDM (the same test is also valid for quintessence inflation models, imposing that they match with the recent observational data provided by the BICEP and Planck’s team and leading to a reheating temperature, which is obtained via gravitational particle production after inflation, supporting the nucleosynthesis success.

  1. Reheating via Gravitational Particle Production in Simple Models of Quintessence or ΛCDM Inflation

    Science.gov (United States)

    de Haro, Jaume; Aresté Saló, Llibert

    2017-11-01

    We have tested some simple $Lambda$CDM (the same test is also valid for quintessence) inflation models, imposing that they match with the recent observational data provided by the BICEP and Planck's team and leading to a reheating temperature, which is obtained via gravitational particle production after inflation, supporting the nucleosynthesis success.

  2. A simple and efficient parallel FFT algorithm using the BSP model

    NARCIS (Netherlands)

    Bisseling, R.H.; Inda, M.A.

    2000-01-01

    In this paper we present a new parallel radix FFT algorithm based on the BSP model Our parallel algorithm uses the groupcyclic distribution family which makes it simple to understand and easy to implement We show how to reduce the com munication cost of the algorithm by a factor of three in the case

  3. Using of Video Modeling in Teaching a Simple Meal Preparation Skill for Pupils of Down Syndrome

    Science.gov (United States)

    AL-Salahat, Mohammad Mousa

    2016-01-01

    The current study aimed to identify the impact of video modeling upon teaching three pupils with Down syndrome the skill of preparing a simple meal (sandwich), where the training was conducted in a separate classroom in schools of normal students. The training consisted of (i) watching the video of an intellectually disabled pupil, who is…

  4. Simple One-Dimensional Quantum-Mechanical Model for a Particle Attached to a Surface

    Science.gov (United States)

    Fernandez, Francisco M.

    2010-01-01

    We present a simple one-dimensional quantum-mechanical model for a particle attached to a surface. It leads to the Schrodinger equation for a harmonic oscillator bounded on one side that we solve in terms of Weber functions and discuss the behaviour of the eigenvalues and eigenfunctions. We derive the virial theorem and other exact relationships…

  5. A simple global Budyko model to partition evaporation into interception and transpiration

    NARCIS (Netherlands)

    Mianabadi, A.; Coenders, Miriam; Shirazi, P.; Ghahraman, B.; Alizadeh, Amin

    2017-01-01

    Evaporation is a very important flux in the hydrological cycle and links the water and energy balance of a catchment. The Budyko framework is often used to provide a first order estimate of evaporation, since it is a simple model where only rainfall and potential evaporation is required as input.

  6. Simple model to study the effect of temperature on the greenhouse ...

    African Journals Online (AJOL)

    Due to high solar intensity, the internal temperature of greenhouses in subtropical regions is so high that it is difficult for crops to survive. There are two types of shading nets that are applied to reduce the solar intensity entering the greenhouse. The purpose of this research is to develop a simple greenhouse model to ...

  7. Examining the Simple View of Reading Model for United States High School Spanish Students

    Science.gov (United States)

    Sparks, Richard; Patton, Jon

    2016-01-01

    The Simple View of Reading (SVR) model, which posits that reading comprehension is the product of word decoding and language comprehension that make independent contributions to reading skill, has been found to explain the acquisition of first language (L1) reading and second language (L2) reading in young English language learners (ELLs).…

  8. Simple Entropic Derivation of a Generalized Black-Scholes Option Pricing Model

    Directory of Open Access Journals (Sweden)

    Michael J. Stutzer

    2000-04-01

    Full Text Available Abstract: A straightforward derivation of the celebrated Black-Scholes Option Pricing model is obtained by solution of a simple constrained minimization of relative entropy. The derivation leads to a natural generalization of it, which is consistent with some evidence from stock index option markets.

  9. Simple heat conduction model with phase change for reactor fuel pin

    International Nuclear Information System (INIS)

    Chen, W.L.; Ishii, M.; Grolmes, M.A.

    1976-01-01

    A simple conduction model with phase change has been developed for the transient analysis of a reactor fuel pin based on average properties and lumped parameter techniques. Using the predetermined average overall heat transfer coefficient across a fuel pin in the steady-state period, the average transient fuel and clad temperatures can be formulated analytically. For loss-of-flow at constant power, the start of melting and complete melting for both the fuel and clad can be estimated with considerable accuracy. The purpose of the analysis is to provide a simple useful tool to obtain the general information about fuel and clad leading into the cooling transients. At present, the formulation is being employed for cladding motion and cladding blockage formation in the subassembly of a reactor core. The solution of the simple conduction model for the incipient melting time and the complete melting time of the clad in both R-5 and L-2 test fuel pins was compared with the numerical solution obtained from the SAS code, and the agreement between both solutions is excellent. For the R-5 test case, the analytical solution of the simple conduction model for the complete melting times for both clad and fuel was further compared with numerical solution calculated from THTB code at various axial position of the fuel pin. The comparison shows good agreement. The present lumped parameter model for a fuel pin has been developed to be used in an analysis of multichannel clad motions in a loss-of-flow accident

  10. A simple model for 2D image upconversion of incoherent light

    DEFF Research Database (Denmark)

    Dam, Jeppe Seidelin; Pedersen, Christian; Tidemand-Lichtenberg, Peter

    2011-01-01

    We present a simple theoretical model for 2 dimensional (2-D) image up-conversion of incoherent light. While image upconversion has been known for more than 40 years, the technology has been hindered by very low conversion quantum efficiency (~10-7). We show that our implementation compared...

  11. Surface pressure model for simple delta wings at high angles of attack

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Understanding this aids in the development of simple model structures in agreement with the changes in the flow behaviour. Second, small amplitude unsteady aerodynamic characteristics are directly related to the static characteristics. Flight mechanics analysis is primarily concerned with the aerodynamic data composed ...

  12. A simple model for atomic layer doped field-effect transistor (ALD-FET) electronic states

    International Nuclear Information System (INIS)

    Mora R, M.E.; Gaggero S, L.M.

    1998-01-01

    We propose a simple potential model based on the Thomas-Fermi approximation to reproduce the main properties of the electronic structure of an atomic layer doped field effect transistor. Preliminary numerical results for a Si-based ALD-FET justify why bound electronic states are not observed in the experiment. (Author)

  13. A simple, inexpensive method for preparing cell lysates suitable for downstream reverse transcription quantitative PCR.

    Science.gov (United States)

    Shatzkes, Kenneth; Teferedegne, Belete; Murata, Haruhiko

    2014-04-11

    Sample nucleic acid purification can often be rate-limiting for conventional quantitative PCR (qPCR) workflows. We recently developed high-throughput virus microneutralization assays using an endpoint assessment approach based on reverse transcription qPCR (RT-qPCR). The need for cumbersome RNA purification is circumvented in our assays by making use of a commercial reagent that can easily generate crude cell lysates amenable to direct analysis by one-step RT-qPCR. In the present study, we demonstrate that a simple buffer containing a non-ionic detergent can serve as an inexpensive alternative to commercially available reagents for the purpose of generating RT-qPCR-ready cell lysates from MDCK cells infected with influenza virus. We have found that addition of exogenous RNase inhibitor as a buffer component is not essential in order to maintain RNA integrity, even following stress at 37 °C incubation for 1-2 hours, in cell-lysate samples either freshly prepared or previously stored frozen at -80 °C.

  14. A simple model of bipartite cooperation for ecological and organizational networks.

    Science.gov (United States)

    Saavedra, Serguei; Reed-Tsochas, Felix; Uzzi, Brian

    2009-01-22

    In theoretical ecology, simple stochastic models that satisfy two basic conditions about the distribution of niche values and feeding ranges have proved successful in reproducing the overall structural properties of real food webs, using species richness and connectance as the only input parameters. Recently, more detailed models have incorporated higher levels of constraint in order to reproduce the actual links observed in real food webs. Here, building on previous stochastic models of consumer-resource interactions between species, we propose a highly parsimonious model that can reproduce the overall bipartite structure of cooperative partner-partner interactions, as exemplified by plant-animal mutualistic networks. Our stochastic model of bipartite cooperation uses simple specialization and interaction rules, and only requires three empirical input parameters. We test the bipartite cooperation model on ten large pollination data sets that have been compiled in the literature, and find that it successfully replicates the degree distribution, nestedness and modularity of the empirical networks. These properties are regarded as key to understanding cooperation in mutualistic networks. We also apply our model to an extensive data set of two classes of company engaged in joint production in the garment industry. Using the same metrics, we find that the network of manufacturer-contractor interactions exhibits similar structural patterns to plant-animal pollination networks. This surprising correspondence between ecological and organizational networks suggests that the simple rules of cooperation that generate bipartite networks may be generic, and could prove relevant in many different domains, ranging from biological systems to human society.

  15. Simple intake and pharmacokinetic modeling to characterize exposure of Americans to perfluoroctanoic acid, PFOA.

    Science.gov (United States)

    Lorber, Matthew; Egeghy, Peter P

    2011-10-01

    Models for assessing intakes of perfluorooctanoic acid, PFOA, are described and applied. One model is based on exposure media concentrations and contact rates. This model is applied to general population exposures for adults and 2-year old children. The other model is a simple one-compartment, first-order pharmacokinetic (PK) model. Parameters for this model include a rate of elimination of PFOA and a blood volume of distribution. The model was applied to data from the National Health and Nutritional Examination Survey, NHANES, to backcalculate intakes. The central tendency intake estimate for adults and children based on exposure media concentrations and contact rates were 70 and 26 ng/day, respectively. The central tendency adult intake derived from NHANES data was 56 and 37 ng/day for males and females, respectively. Variability and uncertainty discussions regarding the intake modeling focus on lack of data on direct exposure to PFOA used in consumer products, precursor compounds, and food. Discussions regarding PK modeling focus on the range of blood measurements in NHANES, the appropriateness of the simple PK model, and the uncertainties associated with model parameters. Using the PK model, the 10th and 95th percentile long-term average adult intakes of PFOA are 15 and 130 ng/day.

  16. Application of a simple analytical model to estimate effectiveness of radiation shielding for neutrons

    International Nuclear Information System (INIS)

    Frankle, S.C.; Fitzgerald, D.H.; Hutson, R.L.; Macek, R.J.; Wilkinson, C.A.

    1993-01-01

    Neutron dose equivalent rates have been measured for 800-MeV proton beam spills at the Los Alamos Meson Physics Facility. Neutron detectors were used to measure the neutron dose levels at a number of locations for each beam-spill test, and neutron energy spectra were measured for several beam-spill tests. Estimates of expected levels for various detector locations were made using a simple analytical model developed for 800-MeV proton beam spills. A comparison of measurements and model estimates indicates that the model is reasonably accurate in estimating the neutron dose equivalent rate for simple shielding geometries. The model fails for more complicated shielding geometries, where indirect contributions to the dose equivalent rate can dominate

  17. Distinguishing Little-Higgs product and simple group models at the LHC and ILC

    International Nuclear Information System (INIS)

    Kilian, W.; Rainwater, D.

    2006-09-01

    We propose a means to discriminate between the two basic variants of Little Higgs models, the Product Group and Simple Group models, at the next generation of colliders. It relies on a special coupling of light pseudoscalar particles present in Little Higgs models, the pseudo-axions, to the Z and the Higgs boson, which is present only in Simple Group models. We discuss the collider phenomenology of the pseudo-axion in the presence of such a coupling at the LHC, where resonant production and decay of either the Higgs or the pseudo-axion induced by that coupling can be observed for much of parameter space. The full allowed range of parameters, including regions where the observability is limited at the LHC, is covered by a future ILC, where double scalar production would be a golden channel to look for. (orig.)

  18. Rank Set Sampling in Improving the Estimates of Simple Regression Model

    Directory of Open Access Journals (Sweden)

    M Iqbal Jeelani

    2015-04-01

    Full Text Available In this paper Rank set sampling (RSS is introduced with a view of increasing the efficiency of estimates of Simple regression model. Regression model is considered with respect to samples taken from sampling techniques like Simple random sampling (SRS, Systematic sampling (SYS and Rank set sampling (RSS. It is found that R2 and Adj R2 obtained from regression model based on Rank set sample is higher than rest of two sampling schemes. Similarly Root mean square error, p-values, coefficient of variation are much lower in Rank set based regression model, also under validation technique (Jackknifing there is consistency in the measure of R2, Adj R2 and RMSE in case of RSS as compared to SRS and SYS. Results are supported with an empirical study involving a real data set generated of Pinus Wallichiana taken from block Langate of district Kupwara. 

  19. A simple method to measure cell viability in proliferation and cytotoxicity assays.

    Science.gov (United States)

    Borra, Ricardo Carneiro; Lotufo, Mônica Andrade; Gagioti, Sonia Maria; Barros, Fabiana de Mesquita; Andrade, Priscila Maria

    2009-01-01

    Resazurin dye has been broadly used as indicator of cell viability in several types of assays for evaluation of the biocompatibility of medical and dental materials. Mitochondrial enzymes, as carriers of diaphorase activities, are probably responsible for the transference of electrons from NADPH + H+ to resazurin, which is reduced to resorufin. The level of reduction can be quantified by spectrophotometers since resazurin exhibits an absorption peak at 600 etam and resorufin at 570 etam wavelengths. However, the requirement of a spectrophotometer and specific filters for the quantification could be a barrier to many laboratories. Digital cameras containing red, green and blue filters, which allow the capture of red (600 to 700 etam) and green (500 to 600 etam) light wavelengths in ranges bordering on resazurin and resorufin absorption bands, could be used as an alternative method for the assessment of resazurin and resorufin concentrations. Thus, our aim was to develop a simple, cheap and precise method based on a digital CCD camera to measure the reduction of resazurin. We compared the capability of the CCD-based method to distinguish different concentrations of L929 and normal Human buccal fibroblast cell lines with that of a conventional microplate reader. The correlation was analyzed through the Pearson coefficient. The results showed a strong association between the measurements of the method developed here and those made with the microplate reader (r(2) = 0.996; p < 0.01) and with the cellular concentrations (r(2) = 0.965; p < 0.01). We concluded that the developed Colorimetric Quantification System based on CCD Images allowed rapid assessment of the cultured cell concentrations with simple equipment at a reduced cost.

  20. Statistical power analysis a simple and general model for traditional and modern hypothesis tests

    CERN Document Server

    Murphy, Kevin R; Wolach, Allen

    2014-01-01

    Noted for its accessible approach, this text applies the latest approaches of power analysis to both null hypothesis and minimum-effect testing using the same basic unified model. Through the use of a few simple procedures and examples, the authors show readers with little expertise in statistical analysis how to obtain the values needed to carry out the power analysis for their research. Illustrations of how these analyses work and how they can be used to choose the appropriate criterion for defining statistically significant outcomes are sprinkled throughout. The book presents a simple and g

  1. Spectral reflectance of solar light from dirty snow: a simple theoretical model and its validation

    Directory of Open Access Journals (Sweden)

    A. Kokhanovsky

    2013-08-01

    Full Text Available A simple analytical equation for the snow albedo as the function of snow grain size, soot concentration, and soot mass absorption coefficient is presented. This simple equation can be used in climate models to assess the influence of snow pollution on snow albedo. It is shown that the squared logarithm of the albedo (in the visible is directly proportional to the soot concentration. A new method of the determination of the soot mass absorption coefficient in snow is proposed. The equations derived are applied to a dusty snow layer as well.

  2. Theoretical Evaluation of the Sediment/Water Exchange Description in Generic Compartment Models (SimpleBox)

    DEFF Research Database (Denmark)

    Sørensen, P. B.; Fauser, P.; Carlsen, L.

    It is shown how diffusion and deposition of solids drive the flux of substance between the water column and the sediment. The generic compartment models (Mackay type) use a one box model for the sediment in order to keep the calculations simple. However, when diffusion needs to be included...... where diffusion or deposition is negligible or where both processes must be included in order to describe the sediment-water substance exchange most appropriately....

  3. A simple spatiotemporal rabies model for skunk and bat interaction in northeast Texas.

    Science.gov (United States)

    Borchering, Rebecca K; Liu, Hao; Steinhaus, Mara C; Gardner, Carl L; Kuang, Yang

    2012-12-07

    We formulate a simple partial differential equation model in an effort to qualitatively reproduce the spread dynamics and spatial pattern of rabies in northeast Texas with overlapping reservoir species (skunks and bats). Most existing models ignore reservoir species or model them with patchy models by ordinary differential equations. In our model, we incorporate interspecies rabies infection in addition to rabid population random movement. We apply this model to the confirmed case data from northeast Texas with most parameter values obtained or computed from the literature. Results of simulations using both our skunk-only model and our skunk and bat model demonstrate that the model with overlapping reservoir species more accurately reproduces the progression of rabies spread in northeast Texas. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. A simple and efficient method for deriving neurospheres from bone marrow stromal cells

    International Nuclear Information System (INIS)

    Yang Qin; Mu Jun; Li Qi; Li Ao; Zeng Zhilei; Yang Jun; Zhang Xiaodong; Tang Jin; Xie Peng

    2008-01-01

    Bone marrow stromal cells (MSCs) can be differentiated into neuronal and glial-like cell types under appropriate experimental conditions. However, previously reported methods are complicated and involve the use of toxic reagents. Here, we present a simplified and nontoxic method for efficient conversion of rat MSCs into neurospheres that express the neuroectodermal marker nestin. These neurospheres can proliferate and differentiate into neuron, astrocyte, and oligodendrocyte phenotypes. We thus propose that MSCs are an emerging model cell for the treatment of a variety of neurological diseases

  5. Simple, fast and accurate two-diode model for photovoltaic modules

    Energy Technology Data Exchange (ETDEWEB)

    Ishaque, Kashif; Salam, Zainal; Taheri, Hamed [Faculty of Electrical Engineering, Universiti Teknologi Malaysia, UTM 81310, Skudai, Johor Bahru (Malaysia)

    2011-02-15

    This paper proposes an improved modeling approach for the two-diode model of photovoltaic (PV) module. The main contribution of this work is the simplification of the current equation, in which only four parameters are required, compared to six or more in the previously developed two-diode models. Furthermore the values of the series and parallel resistances are computed using a simple and fast iterative method. To validate the accuracy of the proposed model, six PV modules of different types (multi-crystalline, mono-crystalline and thin-film) from various manufacturers are tested. The performance of the model is evaluated against the popular single diode models. It is found that the proposed model is superior when subjected to irradiance and temperature variations. In particular the model matches very accurately for all important points of the I-V curves, i.e. the peak power, short-circuit current and open circuit voltage. The modeling method is useful for PV power converter designers and circuit simulator developers who require simple, fast yet accurate model for the PV module. (author)

  6. A simple method for establishing an ostrich model of femoral head osteonecrosis and collapse.

    Science.gov (United States)

    Jiang, Wenxue; Wang, Pengfei; Wan, Yanlin; Xin, Dasen; Fan, Meng

    2015-05-21

    This study aimed to develop a simple method of creating an animal model of non-trauma femoral head osteonecrosis and collapse using African ostriches with weights similar to those of humans. Eighteen African ostriches were subjected to liquid nitrogen cryo-insult in the unilateral femoral head through surgical procedures using homemade cryogenic equipment combined with tract drilling inside the femoral head. Three animals were sacrificed at postoperative weeks 6 and 12, respectively, and the remaining animals were sacrificed at postoperative week 24. Bilateral femoral heads were harvested and subjected to gross observation, histological examination using hematoxylin and eosin staining, and radiographic examination. Micro-computed tomography was performed on a portion of the specimens at postoperative week 24, and angiographic examination of the femoral head was performed before sacrificing the animals. Eight ostriches developed a limp at postoperative week 8, with a mean duration of 16.5 weeks. The postoperative femoral head specimens showed changes in contour and articular cartilage degeneration. Sagittal sectioning of the collapsed femoral head specimens revealed distinct boundaries among the osteonecrotic areas, osteosclerotic areas, and normal trabeculae. Histological examinations revealed active bone resorption in the osteonecrotic area of the subchondral bone, an increased number of fat cells, and active trabecular bone regeneration in the osteosclerotic areas. The postoperative radiographic examinations revealed that the height of the femoral head gradually decreased and progressed to collapse. Micro-computed tomography scans showed the interrupted trabecular bone with an irregular shape in the collapsed femoral head. Compared with the normal samples, angiographic findings revealed interrupted blood supply of the cryo-injured samples in some areas of the femoral heads, blood vessel narrowing, and decreased number of blood vessels in the cryo-injured areas

  7. New, simple theory-based, accurate polarization microscope for birefringence imaging of biological cells

    Science.gov (United States)

    Shin, In Hee; Shin, Sang-Mo; Kim, Dug Young

    2010-01-01

    We propose a new, simple theory-based, accurate polarization microscope for birefringence imaging of cytoskeletal structures of biological cells. The new theory lets us calculate very easily the phase retardation and the orientation of the principal axis of a particular area of a biological living cell in media by simply measuring the intensity variation of a pixel of a CCD camera while rotating a single polarizer. Just from the measured intensity maxima and minima, the amount of phase retardation δ between the fast and the slow axis of the sample area is obtained with an accuracy of 5.010+/-0.798×10-3 rad. The orientation of the principal axis is calculated from the angle of the polarizer for the intensity maximum. We have compared our microscopes with two previously reported polarization microscopes for birefringence imaging of cytoskeletal structures and demonstrated the utility of our microscope with the phase retardation and orientation images of weakly invasive MCF7 and highly invasive MDA MB 231 human breast cancer cells as an example.

  8. A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture.

    Science.gov (United States)

    Valente, Andrew J; Maddalena, Lucas A; Robb, Ellen L; Moradi, Fereshteh; Stuart, Jeffrey A

    2017-04-01

    Mitochondria exist in a dynamic cycle of fusion and fission whose balance directly influences the morphology of the 'mitochondrial network', a term that encompasses the branched, reticular structure of fused mitochondria as well as the separate, punctate individual organelles within a eukaryotic cell. Over the past decade, the significance of the mitochondrial network has been increasingly appreciated, motivating the development of various approaches to analyze it. Here, we describe the Mitochondrial Network Analysis (MiNA) toolset, a relatively simple pair of macros making use of existing ImageJ plug-ins, allowing for semi-automated analysis of mitochondrial networks in cultured mammalian cells. MiNA is freely available at https://github.com/ScienceToolkit/MiNA. The tool incorporates optional preprocessing steps to enhance the quality of images before converting the images to binary and producing a morphological skeleton for calculating nine parameters to quantitatively capture the morphology of the mitochondrial network. The efficacy of the macro toolset is demonstrated using a sample set of images from SH-SY5Y, C2C12, and mouse embryo fibroblast (MEF) cell cultures treated under different conditions and exhibiting hyperfused, fused, and fragmented mitochondrial network morphologies. Copyright © 2017 Elsevier GmbH. All rights reserved.

  9. Application of a simple Ramsauer model for neutron total cross sections

    International Nuclear Information System (INIS)

    Bauer, R.W.; Anderson, J.D.; Grimes, S.M.; Knapp, D.A.; Madsen, V.A.

    1998-01-01

    A companion paper presented arguments that support the applicability of a simple Ramsauer model to describe neutron total cross sections. Such a model yields a simple equation for the energy dependence of the cross section of a given nucleus and also allows extrapolation to nuclei of other A values. Fits of the Ramsauer form to very precise total cross sections recently measured over an extended energy range are presented. Very good fits are obtained for neutron energies between 6 and 60 MeV, suggesting that this approach will be useful for estimating cross sections in cases where experimental data are unavailable. Extension of this model to 120 MeV was only moderately successful

  10. A simple multistage closed-(box+reservoir model of chemical evolution

    Directory of Open Access Journals (Sweden)

    Caimmi R.

    2011-01-01

    Full Text Available Simple closed-box (CB models of chemical evolution are extended on two respects, namely (i simple closed-(box+reservoir (CBR models allowing gas outflow from the box into the reservoir (Hartwick 1976 or gas inflow into the box from the reservoir (Caimmi 2007 with rate proportional to the star formation rate, and (ii simple multistage closed-(box+reservoir (MCBR models allowing different stages of evolution characterized by different inflow or outflow rates. The theoretical differential oxygen abundance distribution (TDOD predicted by the model maintains close to a continuous broken straight line. An application is made where a fictitious sample is built up from two distinct samples of halo stars and taken as representative of the inner Galactic halo. The related empirical differential oxygen abundance distribution (EDOD is represented, to an acceptable extent, as a continuous broken line for two viable [O/H]-[Fe/H] empirical relations. The slopes and the intercepts of the regression lines are determined, and then used as input parameters to MCBR models. Within the errors (-+σ, regression line slopes correspond to a large inflow during the earlier stage of evolution and to low or moderate outflow during the subsequent stages. A possible inner halo - outer (metal-poor bulge connection is also briefly discussed. Quantitative results cannot be considered for applications to the inner Galactic halo, unless selection effects and disk contamination are removed from halo samples, and discrepancies between different oxygen abundance determination methods are explained.

  11. Calibration of a simple and a complex model of global marine biogeochemistry

    Science.gov (United States)

    Kriest, Iris

    2017-11-01

    The assessment of the ocean biota's role in climate change is often carried out with global biogeochemical ocean models that contain many components and involve a high level of parametric uncertainty. Because many data that relate to tracers included in a model are only sparsely observed, assessment of model skill is often restricted to tracers that can be easily measured and assembled. Examination of the models' fit to climatologies of inorganic tracers, after the models have been spun up to steady state, is a common but computationally expensive procedure to assess model performance and reliability. Using new tools that have become available for global model assessment and calibration in steady state, this paper examines two different model types - a complex seven-component model (MOPS) and a very simple four-component model (RetroMOPS) - for their fit to dissolved quantities. Before comparing the models, a subset of their biogeochemical parameters has been optimised against annual-mean nutrients and oxygen. Both model types fit the observations almost equally well. The simple model contains only two nutrients: oxygen and dissolved organic phosphorus (DOP). Its misfit and large-scale tracer distributions are sensitive to the parameterisation of DOP production and decay. The spatio-temporal decoupling of nitrogen and oxygen, and processes involved in their uptake and release, renders oxygen and nitrate valuable tracers for model calibration. In addition, the non-conservative nature of these tracers (with respect to their upper boundary condition) introduces the global bias (fixed nitrogen and oxygen inventory) as a useful additional constraint on model parameters. Dissolved organic phosphorus at the surface behaves antagonistically to phosphate, and suggests that observations of this tracer - although difficult to measure - may be an important asset for model calibration.

  12. Simple solution-processed CuOX as anode buffer layer for efficient organic solar cells

    International Nuclear Information System (INIS)

    Shen, Wenfei; Yang, Chunpeng; Bao, Xichang; Sun, Liang; Wang, Ning; Tang, Jianguo; Chen, Weichao; Yang, Renqiang

    2015-01-01

    Graphical abstract: - Highlights: • Simple solution-processed CuO X hole transport layer for efficient organic solar cell. • Good photovoltaic performances as hole transport layer in OSCs with P3HT and PBDTTT-C as donor materials. • The device with CuO X as hole transport layer shows great improved stability compared with that of device with PEDOT:PSS as hole transport layer. - Abstract: A simple, solution-processed ultrathin CuO X anode buffer layer was fabricated for high performance organic solar cells (OSCs). XPS measurement demonstrated that the CuO X was the composite of CuO and Cu 2 O. The CuO X modified ITO glass exhibit a better surface contact with the active layer. The photovoltaic performance of the devices with CuO X layer was optimized by varying the thickness of CuO X films through changing solution concentration. With P3HT:PC 61 BM as the active layer, we demonstrated an enhanced PCE of 4.14% with CuO X anode buffer layer, compared with that of PEDOT:PSS layer. The CuO X layer also exhibits efficient photovoltaic performance in devices with PBDTTT-C:PC 71 BM as the active layer. The long-term stability of CuO X device is better than that of PEDOT:PSS device. The results indicate that the easy solution-processed CuO X film can act as an efficient anode buffer layer for high-efficiency OSCs

  13. Reducing Hypoxia in the Northern Gulf of Mexico: Lessons from Simple and Complex Models

    Science.gov (United States)

    Justic, D.; Fertitta, D. A.; Wang, L.

    2016-02-01

    Gulf hypoxia has received considerable scientific and policy attention because of its large size (up to 22,000 square km), potential ecological and economic effects, and the need to understand the implications of various nutrient management strategies in the large Mississippi River watershed. Over the past 20 years, a number of different models have been developed to simulate the severity and areal extent of hypoxia in the northern Gulf of Mexico, and to predict the consequences of management actions. The models range from simple statistical models to complex three-dimensional fully coupled hydrodynamic-biogeochemical models. The size and the complexity of these models have been steadily increasing due to developments in computer technology and computational techniques, and also in response to new scientific paradigms that have emerged over time forcing modelers to broaden the scope of their original models. We presentan overview of hypoxia models developed for the Gulf of Mexico hypoxic zone and discuss the lessons learned, and some fundamental differences between simple and complex models in evaluating the effectiveness of nutrient management strategies for reducing hypoxia.

  14. A simple macroscopic root water uptake model based on the hydraulic architecture approach

    Science.gov (United States)

    Couvreur, V.; Vanderborght, J.; Javaux, M.

    2012-12-01

    Many hydrological models including root water uptake (RWU) do not consider the dimension of root system hydraulic architecture (HA) because explicitly solving water flow in such a complex system is too time consuming. However, they might lack process understanding when basing RWU and plant water stress predictions on functions of variables such as the root length density distribution. On the basis of analytical solutions of water flow in a simple HA, we developed a model implicitly accounting for the root system HA, allowing the simulation of both RWU distribution and plant water stress, in three-dimensional soil water flow models. The new model has three macroscopic parameters defined at the soil element scale, or at the plant scale, rather than for each segment of the root system architecture: the standard sink fraction distribution SSF, the root system equivalent conductance Krs and the compensatory RWU conductance Kcomp. It clearly decouples the process of water stress from compensatory RWU, and its structure is appropriate for hydraulic lift simulation. As compared to a model explicitly solving water flow in a complex root system HA, the new model showed to be accurate and fast, in dissimilar water dynamics scenarios, while keeping the same parameter set. With the proposed model, new concepts are brought which open avenues towards simple and mechanistic RWU models and water stress functions operational for field scale water dynamics simulation. A further study focuses on its applicability for simulating one-dimensional water dynamics in wheat cropped fields.

  15. The impact of realistic age structure in simple models of tuberculosis transmission.

    Science.gov (United States)

    Brooks-Pollock, Ellen; Cohen, Ted; Murray, Megan

    2010-01-07

    Mathematical models of tuberculosis (TB) transmission have been used to characterize disease dynamics, investigate the potential effects of public health interventions, and prioritize control measures. While previous work has addressed the mathematical description of TB natural history, the impact of demography on the behaviour of TB models has not been assessed. A simple model of TB transmission, with alternative assumptions about survivorship, is used to explore the effect of age structure on the prevalence of infection, disease, basic reproductive ratio and the projected impact of control interventions. We focus our analytic arguments on the differences between constant and exponentially distributed lifespans and use an individual-based model to investigate the range of behaviour arising from realistic distributions of survivorship. The choice of age structure and natural (non-disease related) mortality strongly affects steady-state dynamics, parameter estimation and predictions about the effectiveness of control interventions. Since most individuals infected with TB develop an asymptomatic latent infection and never progress to active disease, we find that assuming a constant mortality rate results in a larger reproductive ratio and an overestimation of the effort required for disease control in comparison to using more realistic age-specific mortality rates. Demographic modelling assumptions should be considered in the interpretation of models of chronic infectious diseases such as TB. For simple models, we find that assuming constant lifetimes, rather than exponential lifetimes, produces dynamics more representative of models with realistic age structure.

  16. A simple model of gas flow in a porous powder compact

    Energy Technology Data Exchange (ETDEWEB)

    Shugard, Andrew D. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Robinson, David B. [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2014-04-01

    This report describes a simple model for ideal gas flow from a vessel through a bed of porous material into another vessel. It assumes constant temperature and uniform porosity. Transport is treated as a combination of viscous and molecular flow, with no inertial contribution (low Reynolds number). This model can be used to fit data to obtain permeability values, determine flow rates, understand the relative contributions of viscous and molecular flow, and verify volume calibrations. It draws upon the Dusty Gas Model and other detailed studies of gas flow through porous media.

  17. Addressing challenges in single species assessments via a simple state-space assessment model

    DEFF Research Database (Denmark)

    Nielsen, Anders

    Single-species and age-structured fish stock assessments still remains the main tool for managing fish stocks. A simple state-space assessment model is presented as an alternative to (semi) deterministic procedures and the full parametric statistical catch at age models. It offers a solution...... to some of the key challenges of these models. Compared to the deterministic procedures it solves a list of problems originating from falsely assuming that age classified catches are known without errors and allows quantification of uncertainties of estimated quantities of interest. Compared to full...

  18. Characteristics of the FTU scrape-off layer (SOL) determined by a simple 1-D model

    International Nuclear Information System (INIS)

    Ferro, C.

    1994-12-01

    A simple 1-D model analytical model has been developed to determine the SOL characteristics from the parameters of the main plasma. The solutions are compared with FTU experimental data. The solutions fit quite well the experimental data and their trend. Moreover the model suggests the presence of a critical density related to the non isothermal power flux and the corresponding maximum power which can be safely removed by volumetric sinks. Differences between a limiter-like configuration and a divertor-like configuration are described

  19. Simple statistical channel model for weak temperature-induced turbulence in underwater wireless optical communication systems

    KAUST Repository

    Oubei, Hassan M.

    2017-06-16

    In this Letter, we use laser beam intensity fluctuation measurements to model and describe the statistical properties of weak temperature-induced turbulence in underwater wireless optical communication (UWOC) channels. UWOC channels with temperature gradients are modeled by the generalized gamma distribution (GGD) with an excellent goodness of fit to the measured data under all channel conditions. Meanwhile, thermally uniform channels are perfectly described by the simple gamma distribution which is a special case of GGD. To the best of our knowledge, this is the first model that comprehensively describes both thermally uniform and gradient-based UWOC channels.

  20. More scalability, less pain: A simple programming model and its implementation for extreme computing

    International Nuclear Information System (INIS)

    Lusk, E.L.; Pieper, S.C.; Butler, R.M.

    2010-01-01

    This is the story of a simple programming model, its implementation for extreme computing, and a breakthrough in nuclear physics. A critical issue for the future of high-performance computing is the programming model to use on next-generation architectures. Described here is a promising approach: program very large machines by combining a simplified programming model with a scalable library implementation. The presentation takes the form of a case study in nuclear physics. The chosen application addresses fundamental issues in the origins of our Universe, while the library developed to enable this application on the largest computers may have applications beyond this one.

  1. Integrating uncertainty in time series population forecasts: An illustration using a simple projection model

    Directory of Open Access Journals (Sweden)

    Guy J. Abel

    2013-12-01

    Full Text Available Background: Population forecasts are widely used for public policy purposes. Methods to quantify the uncertainty in forecasts tend to ignore model uncertainty and to be based on a single model. Objective: In this paper, we use Bayesian time series models to obtain future population estimates with associated measures of uncertainty. The models are compared based on Bayesian posterior model probabilities, which are then used to provide model-averaged forecasts. Methods: The focus is on a simple projection model with the historical data representing population change in England and Wales from 1841 to 2007. Bayesian forecasts to the year 2032 are obtained based on a range of models, including autoregression models, stochastic volatility models and random variance shift models. The computational steps to fit each of these models using the OpenBUGS software via R are illustrated. Results: We show that the Bayesian approach is adept in capturing multiple sources of uncertainty in population projections, including model uncertainty. The inclusion of non-constant variance improves the fit of the models and provides more realistic predictive uncertainty levels. The forecasting methodology is assessed through fitting the models to various truncated data series.

  2. Simple Model-Free Controller for the Stabilization of Planetary Inverted Pendulum

    Directory of Open Access Journals (Sweden)

    Huanhuan Mai

    2012-01-01

    Full Text Available A simple model-free controller is presented for solving the nonlinear dynamic control problems. As an example of the problem, a planetary gear-type inverted pendulum (PIP is discussed. To control the inherently unstable system which requires real-time control responses, the design of a smart and simple controller is made necessary. The model-free controller proposed includes a swing-up controller part and a stabilization controller part; neither controller has any information about the PIP. Since the input/output scaling parameters of the fuzzy controller are highly sensitive, we use genetic algorithm (GA to obtain the optimal control parameters. The experimental results show the effectiveness and robustness of the present controller.

  3. WORK GROUP DEVELOPMENT MODELS – THE EVOLUTION FROM SIMPLE GROUP TO EFFECTIVE TEAM

    Directory of Open Access Journals (Sweden)

    Raluca ZOLTAN

    2016-02-01

    Full Text Available Currently, work teams are increasingly studied by virtue of the advantages they have compared to the work groups. But a true team does not appear overnight but must complete several steps to overcome the initial stage of its existence as a group. The question that arises is at what point a simple group is turning into an effective team. Even though the development process of group into a team is not a linear process, the models found in the literature provides a rich framework for analyzing and identifying the features which group acquires over time till it become a team in the true sense of word. Thus, in this article we propose an analysis of the main models of group development in order to point out, even in a relative manner, the stage when the simple work group becomes an effective work team.

  4. Simple model to estimate the contribution of atmospheric CO2 to the Earth's greenhouse effect

    Science.gov (United States)

    Wilson, Derrek J.; Gea-Banacloche, Julio

    2012-04-01

    We show how the CO2 contribution to the Earth's greenhouse effect can be estimated from relatively simple physical considerations and readily available spectroscopic data. In particular, we present a calculation of the "climate sensitivity" (that is, the increase in temperature caused by a doubling of the concentration of CO2) in the absence of feedbacks. Our treatment highlights the important role played by the frequency dependence of the CO2 absorption spectrum. For pedagogical purposes, we provide two simple models to visualize different ways in which the atmosphere might return infrared radiation back to the Earth. The more physically realistic model, based on the Schwarzschild radiative transfer equations, uses as input an approximate form of the atmosphere's temperature profile, and thus includes implicitly the effect of heat transfer mechanisms other than radiation.

  5. A Model of Discrete-Continuum Time for a Simple Physical System

    Directory of Open Access Journals (Sweden)

    Karimov A. R.

    2008-04-01

    Full Text Available Proceeding from the assumption that the time flow of an individual object is a real physical value, in the framework of a physical kinetics approach we propose an analogy between time and temperature. The use of such an analogy makes it possible to work out a discrete-continuum model of time for a simple physical system. The possible physical properties of time for the single object and time for the whole system are discussed.

  6. Some simple extensions of the standard model and muon member violation

    International Nuclear Information System (INIS)

    Ng, J.N.

    1994-05-01

    A brief discussion of a systematic study of simple particle extensions to the standard model (SM) is given. The effects of such extensions in lepton number violation processes such as μ → e γ, 3e and μ -e conversion nuclei is given. It is found that μ → e γ and μ -e conversion offer the best opportunities for the discovery of this kind of new physics. (author)

  7. A simple model of the wind turbine induction zone derived from numerical simulations

    DEFF Research Database (Denmark)

    Troldborg, Niels; Meyer Forsting, Alexander Raul

    2017-01-01

    The induction zone in front of different wind turbine rotors is studied by means of steady-state Navier-Stokes simulations combined with an actuator disk approach. It is shown that, for distances beyond 1 rotor radius upstream of the rotors, the induced velocity is self-similar and independent of...... of the rotor geometry. On the basis of these findings, a simple analytical model of the induction zone of wind turbines is proposed....

  8. JSF: JOINT STRIKE FIGHTER OR JUST SIMPLE FAILURE ANALYZING THE F-35S JOINT ACQUISITION MODEL

    Science.gov (United States)

    2016-02-01

    performance. It will analyze the advantages and disadvantages realized by the joint model before recommending a path forward for future fighter...as the AV-8Bs that are also in the Marines. If the F-35 were to not be a joint venture , the Navy and Marines would also be forced to develop their...AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY JSF: Joint Strike Fighter or Just Simple Failure? Analyzing the F-35’s Joint Acquisition

  9. A simple model for 100 K-year oscillations in glaciation

    Science.gov (United States)

    Lindzen, R. S.

    1986-01-01

    A simple climatic model which produces glaciation cycles of 100 K periods in response to forcing by 20 K, 40 K, and 100 K periods is described. The model is based on Milankovitch's (1930) hypothesis that glaciation fluctuations are forced by orbital variation and the associated change in insolation. The sea ice/snow cover line for the model, and the relation between heat variations and the ice/snow line are analyzed. The sea ice/snow cover line for the model is between the pole and 53 deg latitude and the line's position is the forcing for the glaciation cycle. Examples of the model's response to forcing are presented and evaluated. The negative glaciation permitted by the model is studied. The role of CO2 feedback in the glaciation cycle is investigated.

  10. Understanding the Shape of the Land and Watersheds Using Simple Models in the Classroom

    Science.gov (United States)

    Gardiner, L.; Johnson, R.; Russell, R.; Bergman, J.; Genyuk, J.; Lagrave, M.

    2006-12-01

    Middle school students can gain essential understandings of the Earth and its processes in the classroom by making and manipulating simple models. While no substitute for field experiences, simple models made of easily-obtained materials can foster student understanding of natural environments. Through this collection of hands-on activities, students build and manipulate simple models that demonstrate (1) tectonic processes that shape the land, (2) the shape of the land surface, (3) how the shape of the land influences the distribution of waterways and watersheds, and (4) how the human communities within a watershed are interconnected through use of surface water. The classroom activities described in this presentation are available on Windows to the Universe (www.windows.ucar.edu), a project of the University Corporation for Atmospheric Research Office of Education and Outreach. Windows to the Universe, a long-standing Web resource supporting Earth and space science education, provides users with content about the Earth and space sciences at three levels (beginner, intermediate, and advanced) in English and Spanish. Approximately 80 hands-on classroom activities appropriate for K-12 classrooms are available within the teacher resources section of the Windows to the Universe.

  11. Trans and cis influences and effects in cobalamins and in their simple models.

    Science.gov (United States)

    De March, Matteo; Demitri, Nicola; Geremia, Silvano; Hickey, Neal; Randaccio, Lucio

    2012-11-01

    The interligand interactions in coordination compounds have been principally interpreted in terms of cis and trans influences and effects, which can be defined as the ability of a ligand X to affect the bond of another ligand, cis or trans to X, to the metal. This review analyzes these effects/influences in cobalamins (XCbl) and their simple models cobaloximes, LCo(chel)X. Important properties of these complexes, such as geometry, stability, and reactivity, can be rationalized in terms of steric and electronic factors of the ligands. Experimental evidence of normal and inverse trans influence is described in alkylcobaloximes for the first time. The study of simple B(12) models has complemented that on the more complex cobalamins, with particular emphasis on the properties of the axial L-Co-X moiety. Some of the conclusions reached for the axial fragment of simple models have also been qualitatively detected in cobalamins and have furnished new insight into the as yet unestablished mechanism for the homolytic cleavage of the Co - C bond in the AdoCbl-based enzymes. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Potts model for exaggeration of a simple rumor transmitted by recreant rumormongers.

    Science.gov (United States)

    Liu, Z; Luo, J; Shao, C

    2001-10-01

    A simple rumor transmitted by recreant rumormongers is considered quantitatively. The simple message contained in the rumor is represented by a simple proposition that has been universally quantified. The operations to change the proposition by rumormongers are established. To describe the rumor's transmission along different channels mathematically, a spin chain is introduced, in which spins represent the operations. The addition of spins is established according to the laws of operations. The result of a rumor's transmission is given by the chain's spin sum. The model, which is favorable for a social prognostication, can determine quantitatively how the social guide and the competition among various opinions affect the exaggeration of the simple rumor transmitted by recreant rumormongers. It proves that the rumor forms Potts-like spin chains in the case with maximum information entropy. The approximate calculation shows that the rumor may be aggrandized little or aggrandized normally, even sometimes catastrophically. Moreover, the exaggeration is greater when the guide is larger and the competition is lower.

  13. A simple model for predicting solute concentration in agricultural tile lines shortly after application

    Directory of Open Access Journals (Sweden)

    T. S. Steenhuis

    1997-01-01

    Full Text Available Agricultural tile drainage lines have been implicated as a source of pesticide contamination of surface waters. Field experiments were conducted and a simple model was developed to examine preferential transport of applied chemicals to agricultural tile lines. The conceptual model consists of two linear reservoirs, one near the soil surface and one near the tile drain. The connection between the two reservoirs is via preferential flow paths with very little interaction with the soil matrix. The model assumes that only part of the field contributes solutes to the tile drain. The model was evaluated with data from the field experiments in which chloride, 2,4-D, and atrazine concentrations were measured on eight tile-drained plots that were irrigated twice. Atrazine was applied two months prior to the experiment, 2,4-D was sprayed just before the first irrigation, and chloride before the second irrigation. All three chemicals were found in the tile effluent shortly after the rainfall began. Generally, the concentration increased with increased flow rates and decreased exponentially after the rainfall ceased. Although the simple model could simulate the observed chloride concentration patterns in the tile outflow for six of the eight plots, strict validation was not possible because of the difficulty with independent measurement of the data needed for a preferential flow model applied to field conditions. The results show that, to simulate pesticide concentration in tile lines, methods that can measure field averaged preferential flow characteristics need to be developed.

  14. Utilising temperature differences as constraints for estimating parameters in a simple climate model

    International Nuclear Information System (INIS)

    Bodman, Roger W; Karoly, David J; Enting, Ian G

    2010-01-01

    Simple climate models can be used to estimate the global temperature response to increasing greenhouse gases. Changes in the energy balance of the global climate system are represented by equations that necessitate the use of uncertain parameters. The values of these parameters can be estimated from historical observations, model testing, and tuning to more complex models. Efforts have been made at estimating the possible ranges for these parameters. This study continues this process, but demonstrates two new constraints. Previous studies have shown that land-ocean temperature differences are only weakly correlated with global mean temperature for natural internal climate variations. Hence, these temperature differences provide additional information that can be used to help constrain model parameters. In addition, an ocean heat content ratio can also provide a further constraint. A pulse response technique was used to identify relative parameter sensitivity which confirmed the importance of climate sensitivity and ocean vertical diffusivity, but the land-ocean warming ratio and the land-ocean heat exchange coefficient were also found to be important. Experiments demonstrate the utility of the land-ocean temperature difference and ocean heat content ratio for setting parameter values. This work is based on investigations with MAGICC (Model for the Assessment of Greenhouse-gas Induced Climate Change) as the simple climate model.

  15. Simple-II: A new numerical thermal model for predicting thermal performance of Stirling engines

    International Nuclear Information System (INIS)

    Babaelahi, Mojtaba; Sayyaadi, Hoseyn

    2014-01-01

    A new thermal model called Simple-II was presented based on modification of the original Simple analysis. First, the engine was modeled considering adiabatic expansion and compression spaces, in which effect of gas leakage from cylinder to buffer space and shuttle effect of displacer were implemented in the basic differential equations. Moreover, non-ideal thermal operation of the regenerator and the longitudinal heat conduction between heater and cooler through the regenerator wall were considered. Based on the magnitudes of pressure drops in heat exchangers, values of pressure in the expansion and compression spaces were corrected. Furthermore, based on the theory of finite speed thermodynamics (FST), the corresponding power loss due to the piston motion and also the mechanical friction were considered. Simple-II was employed for thermal simulation of a prototype Stirling engine. Finally, result of the new model was evaluated by comprehensive comparison of experimental results with those of the previous models. The output power and thermal efficiency were predicted with +20.7% and +7.1% errors, respectively. Also, the regenerator was demonstrated to be the main source of power and heat losses; nevertheless, other loss mechanisms have reasonable effects on output power and/or thermal efficiency of Stirling engines. - Highlights: • A new thermal model was presented based on various loss mechanisms. • Shuttle effect and mass leakage were integrated into differential equations. • FST, mechanical friction and longitudinal conduction losses were considered. • A methodology was presented for numerical solution and correcting results based on losses. • The new model predicted thermal performance of engine with higher accuracy

  16. Simple analytical model reveals the functional role of embodied sensorimotor interaction in hexapod gaits

    Science.gov (United States)

    Aoi, Shinya; Nachstedt, Timo; Manoonpong, Poramate; Wörgötter, Florentin; Matsuno, Fumitoshi

    2018-01-01

    Insects have various gaits with specific characteristics and can change their gaits smoothly in accordance with their speed. These gaits emerge from the embodied sensorimotor interactions that occur between the insect’s neural control and body dynamic systems through sensory feedback. Sensory feedback plays a critical role in coordinated movements such as locomotion, particularly in stick insects. While many previously developed insect models can generate different insect gaits, the functional role of embodied sensorimotor interactions in the interlimb coordination of insects remains unclear because of their complexity. In this study, we propose a simple physical model that is amenable to mathematical analysis to explain the functional role of these interactions clearly. We focus on a foot contact sensory feedback called phase resetting, which regulates leg retraction timing based on touchdown information. First, we used a hexapod robot to determine whether the distributed decoupled oscillators used for legs with the sensory feedback generate insect-like gaits through embodied sensorimotor interactions. The robot generated two different gaits and one had similar characteristics to insect gaits. Next, we proposed the simple model as a minimal model that allowed us to analyze and explain the gait mechanism through the embodied sensorimotor interactions. The simple model consists of a rigid body with massless springs acting as legs, where the legs are controlled using oscillator phases with phase resetting, and the governed equations are reduced such that they can be explained using only the oscillator phases with some approximations. This simplicity leads to analytical solutions for the hexapod gaits via perturbation analysis, despite the complexity of the embodied sensorimotor interactions. This is the first study to provide an analytical model for insect gaits under these interaction conditions. Our results clarified how this specific foot contact sensory

  17. Rapid and simple purification of elastin-like polypeptides directly from whole cells and cell lysates by organic solvent extraction.

    Science.gov (United States)

    VerHeul, Ross; Sweet, Craig; Thompson, David H

    2018-03-26

    Elastin-like polypeptides (ELP) are a well-known class of proteins that are being increasingly utilized in a variety of biomedical applications, due to their beneficial physicochemical properties. A unifying feature of ELP is their demonstration of a sequence tunable inverse transition temperature (Tt) that enables purification using a simple, straightforward process called inverse transition cycling (ITC). Despite the utility of ITC, the process is inherently limited to ELP with an experimentally accessible Tt. Since the underlying basis for the ELP Tt is related to its high overall hydrophobicity, we anticipated that ELP would be excellent candidates for purification by organic extraction. We report the first method for rapidly purifying ELP directly from whole E. coli cells or clarified lysates using pure organic solvents and solvent mixtures, followed by aqueous back extraction. Our results show that small ELP and a large ELP-fusion protein can be isolated in high yield from whole cells or cell lysates with greater than 95% purity in less than 30 min and with very low levels of LPS and DNA contamination.

  18. A Simple Mathematical Model of the Anaerobic Digestion of Wasted Fruits and Vegetables in Mesophilic Conditions

    Directory of Open Access Journals (Sweden)

    Elena Chorukova

    2015-04-01

    Full Text Available Anaerobic digestion is an effective biotechnological process for treatment of different agricultural, municipal and industrial wastes. Use of mathematical models is a powerful tool for investigations and optimisation of the anaerobic digestion. In this paper a simple mathematical model of the anaerobic digestion of wasted fruits and vegetables was developed and verified experimentally and by computer simulations using Simulink. A three-step mass-balance model was considered including the gas phase. The parameter identification was based on a set of 150 days of dynamical experiments in a laboratory bioreactor. Two step identification procedure to estimate 4 model parameters is presented. The results of 15 days of experiment in a pilot-scale bioreactor were then used to validate the model.

  19. Variation in models for simple dynamic structure–soil–structure interaction problems

    DEFF Research Database (Denmark)

    Andersen, Lars Vabbersgaard; Peplow, Andrew; Bucinskas, Paulius

    2017-01-01

    To account for dynamic cross-coupling of structures via the soil, a computational model must be accurate enough to provide the correct overall behaviour of the scattered wave field. However, simplicity is also important when a model should be used for design purposes, especially in the early design...... stages and feasibility studies. The paper addresses the accuracy of simple models in which an array of structures is simplified into blocks placed on the ground surface or embedded within the soil. Comparisons are made between models that account or do not account, in a proper manner, for the inertia...... and embedment of the structures. Especially, the limitations of simplified models are discussed regarding their capability to quantify the insertion loss accurately. © 2017 The Authors. Published by Elsevier Ltd....

  20. A simple dynamic model and transient simulation of the nuclear power reactor on microcomputers

    Energy Technology Data Exchange (ETDEWEB)

    Han, Yang Gee; Park, Cheol [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-12-31

    A simple dynamic model is developed for the transient simulation of the nuclear power reactor. The dynamic model includes the normalized neutron kinetics model with reactivity feedback effects and the core thermal-hydraulics model. The main objective of this paper demonstrates the capability of the developed dynamic model to simulate various important variables of interest for a nuclear power reactor transient. Some representative results of transient simulations show the expected trends in all cases, even though no available data for comparison. In this work transient simulations are performed on a microcomputer using the DESIRE/N96T continuous system simulation language which is applicable to nuclear power reactor transient analysis. 3 refs., 9 figs. (Author)

  1. Modeling the stylized facts in finance through simple nonlinear adaptive systems

    Science.gov (United States)

    Hommes, Cars H.

    2002-01-01

    Recent work on adaptive systems for modeling financial markets is discussed. Financial markets are viewed as evolutionary systems between different, competing trading strategies. Agents are boundedly rational in the sense that they tend to follow strategies that have performed well, according to realized profits or accumulated wealth, in the recent past. Simple technical trading rules may survive evolutionary competition in a heterogeneous world where prices and beliefs co-evolve over time. Evolutionary models can explain important stylized facts, such as fat tails, clustered volatility, and long memory, of real financial series. PMID:12011401

  2. arXiv A Simple No-Scale Model of Modulus Fixing and Inflation

    CERN Document Server

    Ellis, John; Romano, Antonio Enea; Zapata, Oscar

    We construct a no-scale model of inflation with a single modulus whose real and imaginary parts are fixed by simple power-law corrections to the no-scale K{\\" a}hler potential. Assuming an uplift of the minimum of the effective potential, the model yields a suitable number of e-folds of expansion and values of the tilt in the scalar cosmological density perturbations and of the ratio of tensor and scalar perturbations that are compatible with measurements of the cosmic microwave background radiation.

  3. A simple recipe for modeling reaction-rate in flows with turbulent-combustion

    Science.gov (United States)

    Girimaji, Sharath S.

    1991-01-01

    A computationally viable scheme to account for chemical reaction in turbulent flows is presented. The multivariate beta-pdf model for multiple scalar mixing forms the basis of this scheme. Using the model scalar joint pdf and a general form of the instantaneous reaction-rate, the unclosed chemical reaction terms are expressed as simple functions of scalar means and the turbulent scalar energy. The calculation procedure requires that the mean scalar equations and only one other transport equation - for the turbulent scalar energy - be solved.

  4. Simple Parametric Model for Intensity Calibration of Cassini Composite Infrared Spectrometer Data

    Science.gov (United States)

    Brasunas, J.; Mamoutkine, A.; Gorius, N.

    2016-01-01

    Accurate intensity calibration of a linear Fourier-transform spectrometer typically requires the unknown science target and the two calibration targets to be acquired under identical conditions. We present a simple model suitable for vector calibration that enables accurate calibration via adjustments of measured spectral amplitudes and phases when these three targets are recorded at different detector or optics temperatures. Our model makes calibration more accurate both by minimizing biases due to changing instrument temperatures that are always present at some level and by decreasing estimate variance through incorporating larger averages of science and calibration interferogram scans.

  5. Simple Screened Hydrogen Model of Excitons in Two-Dimensional Materials

    DEFF Research Database (Denmark)

    Olsen, Thomas; Latini, Simone; Rasmussen, Filip Anselm

    2016-01-01

    We present a generalized hydrogen model for the binding energies (EB) and radii of excitons in two-dimensional (2D) materials that sheds light on the fundamental differences between excitons in two and three dimensions. In contrast to the well-known hydrogen model of three-dimensional (3D) excitons......, the description of 2D excitons is complicated by the fact that the screening cannot be assumed to be local. We show that one can consistently define an effective 2D dielectric constant by averaging the screening over the extend of the exciton. For an ideal 2D semiconductor this leads to a simple expression for EB...

  6. On a simple model for self-regulating star formation in the galactic disk

    International Nuclear Information System (INIS)

    Meusinger, H.

    1989-01-01

    Star formation in galaxies is a process with feedback to the interstellar medium (ISM) and possibly it is part of a self-regulating cycle. Dopita (1985) proposed a model in which star formation in spiral and irregular galaxies is self-regulated by the pressure in the ISM. In the present paper it is shown that available data for radial distributions of gas, total mass and the flux of Lyman continuum photons in the disk of our galaxy do not support such a simple model. Several possible causes are discussed. (author)

  7. Can't we just keep it simple? Using thermodynamic limits to formulate simple models and to get robust predictions of the complex Earth system

    Science.gov (United States)

    Kleidon, Axel

    2016-04-01

    The Earth is, undoubtedly, a vastly complex system that is shaped by a range of processes, from solar radiation to planetary motion, geochemical cycling, biotic and human activity, all interacting across a range of time scales to shape the emergent state of the system. The common approach to deal with modelling parts of or the whole Earth system is to build increasingly more comprehensive models, with higher resolutions, a greater range of processes, and a greater number of interactions being represented. Yet, this also yields increasingly incomprehensible models in which the underlying assumptions in the model parameterizations are obscured. I present an alternative approach to model the complex Earth system that focuses on fundamental physical constraints and that allows for insights from simple, back-of-the-envelope calculations. This approach is based on describing the Earth as a thermodynamic system with dynamics that are driven by energy conversions, and in which its complexity is dealt with by the assumption that the dynamics operate at their thermodynamic limit. It requires us to think of Earth system processes in terms of the energy that they convert, the origin of this energy, the interactions that result from the energy conversion, and how these factors shape the resulting thermodynamic limit. The behavior of the complex Earth system then becomes predictable by relatively simple means, not because we deal with a simple system, but because it is so complex that it is ultimately constrained by fundamental thermodynamic limits that can be derived by comparably simple means. I illustrate this approach with three examples, dealing with the hydrologic sensitivity to global warming, the surface energy balance partitioning on land at the diurnal scale, and the limits to wind power as renewable energy. Each example shows that the approach matches observations or complex climate models very well, highlighting that this approach provides a simple alternative to

  8. Comparative Climates of the Trappist-1 Planetary System: Results from a Simple Climate-vegetation Model

    Science.gov (United States)

    Alberti, Tommaso; Carbone, Vincenzo; Lepreti, Fabio; Vecchio, Antonio

    2017-07-01

    The recent discovery of the planetary system hosted by the ultracool dwarf star TRAPPIST-1 could open new paths for investigations of the planetary climates of Earth-sized exoplanets, their atmospheres, and their possible habitability. In this paper, we use a simple climate-vegetation energy-balance model to study the climate of the seven TRAPPIST-1 planets and the climate dependence on various factors: the global albedo, the fraction of vegetation that could cover their surfaces, and the different greenhouse conditions. The model allows us to investigate whether liquid water could be maintained on the planetary surfaces (I.e., by defining a “surface water zone (SWZ)”) in different planetary conditions, with or without the presence of a greenhouse effect. It is shown that planet TRAPPIST-1d seems to be the most stable from an Earth-like perspective, since it resides in the SWZ for a wide range of reasonable values of the model parameters. Moreover, according to the model, outer planets (f, g, and h) cannot host liquid water on their surfaces, even with Earth-like conditions, entering a snowball state. Although very simple, the model allows us to extract the main features of the TRAPPIST-1 planetary climates.

  9. Comparative Climates of the Trappist-1 Planetary System: Results from a Simple Climate-vegetation Model

    Energy Technology Data Exchange (ETDEWEB)

    Alberti, Tommaso; Carbone, Vincenzo; Lepreti, Fabio [Dipartimento di Fisica, Università della Calabria, Ponte P. Bucci, Cubo 31C, I-87036, Rende (CS) (Italy); Vecchio, Antonio, E-mail: tommaso.alberti@unical.it, E-mail: tommasoalberti89@gmail.com [LESIA—Observatoire de Paris, PSL Research University, 5 place Jules Janssen, F-92190, Meudon (France)

    2017-07-20

    The recent discovery of the planetary system hosted by the ultracool dwarf star TRAPPIST-1 could open new paths for investigations of the planetary climates of Earth-sized exoplanets, their atmospheres, and their possible habitability. In this paper, we use a simple climate-vegetation energy-balance model to study the climate of the seven TRAPPIST-1 planets and the climate dependence on various factors: the global albedo, the fraction of vegetation that could cover their surfaces, and the different greenhouse conditions. The model allows us to investigate whether liquid water could be maintained on the planetary surfaces (i.e., by defining a “surface water zone (SWZ)”) in different planetary conditions, with or without the presence of a greenhouse effect. It is shown that planet TRAPPIST-1d seems to be the most stable from an Earth-like perspective, since it resides in the SWZ for a wide range of reasonable values of the model parameters. Moreover, according to the model, outer planets (f, g, and h) cannot host liquid water on their surfaces, even with Earth-like conditions, entering a snowball state. Although very simple, the model allows us to extract the main features of the TRAPPIST-1 planetary climates.

  10. Liquid-liquid critical point in a simple analytical model of water

    Science.gov (United States)

    Urbic, Tomaz

    2016-10-01

    A statistical model for a simple three-dimensional Mercedes-Benz model of water was used to study phase diagrams. This model on a simple level describes the thermal and volumetric properties of waterlike molecules. A molecule is presented as a soft sphere with four directions in which hydrogen bonds can be formed. Two neighboring waters can interact through a van der Waals interaction or an orientation-dependent hydrogen-bonding interaction. For pure water, we explored properties such as molar volume, density, heat capacity, thermal expansion coefficient, and isothermal compressibility and found that the volumetric and thermal properties follow the same trends with temperature as in real water and are in good general agreement with Monte Carlo simulations. The model exhibits also two critical points for liquid-gas transition and transition between low-density and high-density fluid. Coexistence curves and a Widom line for the maximum and minimum in thermal expansion coefficient divides the phase space of the model into three parts: in one part we have gas region, in the second a high-density liquid, and the third region contains low-density liquid.

  11. A simple model to estimate deposition based on a statistical reassessment of global fallout data.

    Science.gov (United States)

    Pálsson, S E; Howard, B J; Bergan, T D; Paatero, J; Isaksson, M; Nielsen, S P

    2013-07-01

    Atmospheric testing of nuclear weapons began in 1945 and largely ceased in 1963. Monitoring of the resulting global fallout was carried out globally by the Environmental Measurements Laboratory and the UK Atomic Energy Research Establishment as well as at national level by some countries. A correlation was identified between fallout deposition and precipitation and an uneven distribution with latitude. In this study, the available data from 1954 to 1976 for (90)Sr and (137)Cs were reanalysed using analysis of covariance (ANCOVA) and logarithmically transformed values of the monthly deposition density as the response variable. Generalized additive models (GAM) were used to explore the relationship of different variables to the response variable and quantify the explanatory power that could be achieved. The explanatory variables which consistently explained most of the variability were precipitation at each site, latitude and change with time and a simple linear model was produced with similar explanatory power as the GAM. The estimates improved as the temporal resolution of the precipitation data increased. A good log-log fit could be obtained if a bias of about 1-6 mm precipitation per month was added, this could be interpreted as dry deposition which is not otherwise accounted for in the model. The deposition rate could then be explained as a simple non-linear power function of the precipitation rate (r(0.2-0.6) depending on latitude band). A similar non-linear power function relationship has been the outcome of some studies linking wash-out and rain-out coefficients with rain intensity. Our results showed that the precipitation rate was an important parameter, not just the total amount. The simple model presented here allows the recreation of the deposition history at a site, allowing comparison with time series of activity concentrations for different environmental compartments, which is important for model validation. Copyright © 2012 Elsevier Ltd. All rights

  12. Simple unification

    International Nuclear Information System (INIS)

    Ponce, W.A.; Zepeda, A.

    1987-08-01

    We present the results obtained from our systematic search of a simple Lie group that unifies weak and electromagnetic interactions in a single truly unified theory. We work with fractionally charged quarks, and allow for particles and antiparticles to belong to the same irreducible representation. We found that models based on SU(6), SU(7), SU(8) and SU(10) are viable candidates for simple unification. (author). 23 refs

  13. Derivation of potential model for LiAlO2 by simple and effective optimization of model parameters

    International Nuclear Information System (INIS)

    Tsuchihira, H.; Oda, T.; Tanaka, S.

    2009-01-01

    Interatomic potentials of LiAlO 2 were constructed by a simple and effective method. In this method, the model function consists of multiple inverse polynomial functions with an exponential truncation function, and parameters in the potential model can be optimized as a solution of simultaneous linear equations. Potential energies obtained by ab initio calculation are used as fitting targets for model parameter optimization. Lattice constants, elastic properties, defect-formation energy, thermal expansions and the melting point were calculated under the constructed potential models. The results showed good agreement with experimental values and ab initio calculation results, which underscores the validity of the presented method.

  14. Quantitative Evaluation of Trapping and Overall Efficiency for Simple Models in One-Degree of Freedom

    CERN Document Server

    Bazzani, A; Giovannozzi, M; Hernalsteens, C

    2013-01-01

    A key ingredient for the Multi-Turn Extraction (MTE) at the CERN Proton Synchrotron is the beam trapping in stable islands of transverse phase space. The control of the trapping process is essential for the quality of the final beam in terms of intensity sharing and emittance. In this paper, a method allowing an analytical estimation of the fraction of beam trapped into resonance islands as a function of the Hamiltonian parameters is presented for a very simple model of the dynamics (pendulum) and is extended to the case of the interpolating Hamiltonian of the H´enon model, the latter being a good 2D model of theMTE dynamics. The analytical results are compared with numerical simulations. Additional numerical simulations are presented for the minimum trapping amplitude and a fitted model is proposed. Results are discussed in detail.

  15. From complex spatial dynamics to simple Markov chain models: do predators and prey leave footprints?

    DEFF Research Database (Denmark)

    Nachman, Gøsta Støger; Borregaard, Michael Krabbe

    2010-01-01

    to another, are then depicted in a state transition diagram, constituting the "footprints" of the underlying population dynamics. We investigate to what extent changes in the population processes modeled in the complex simulation (i.e. the predator's functional response and the dispersal rates of both......In this paper we present a concept for using presence-absence data to recover information on the population dynamics of predator-prey systems. We use a highly complex and spatially explicit simulation model of a predator-prey mite system to generate simple presence-absence data: the number...... of transition probabilities on state variables, and combine this information in a Markov chain transition matrix model. Finally, we use this extended model to predict the long-term dynamics of the system and to reveal its asymptotic steady state properties....

  16. A simple modelling of mass diffusion effects on condensation with noncondensable gases for the CATHARE Code

    Energy Technology Data Exchange (ETDEWEB)

    Coste, P.; Bestion, D. [Commissariat a l Energie Atomique, Grenoble (France)

    1995-09-01

    This paper presents a simple modelling of mass diffusion effects on condensation. In presence of noncondensable gases, the mass diffusion near the interface is modelled using the heat and mass transfer analogy and requires normally an iterative procedure to calculate the interface temperature. Simplifications of the model and of the solution procedure are used without important degradation of the predictions. The model is assessed on experimental data for both film condensation in vertical tubes and direct contact condensation in horizontal tubes, including air-steam, Nitrogen-steam and Helium-steam data. It is implemented in the Cathare code, a french system code for nuclear reactor thermal hydraulics developed by CEA, EDF, and FRAMATOME.

  17. A Simple Physics-Based Model Predicts Oil Production from Thousands of Horizontal Wells in Shales

    KAUST Repository

    Patzek, Tadeusz

    2017-10-18

    Over the last six years, crude oil production from shales and ultra-deep GOM in the United States has accounted for most of the net increase of global oil production. Therefore, it is important to have a good predictive model of oil production and ultimate recovery in shale wells. Here we introduce a simple model of producing oil and solution gas from the horizontal hydrofractured wells. This model is consistent with the basic physics and geometry of the extraction process. We then apply our model thousands of wells in the Eagle Ford shale. Given well geometry, we obtain a one-dimensional nonlinear pressure diffusion equation that governs flow of mostly oil and solution gas. In principle, solutions of this equation depend on many parameters, but in practice and within a given oil shale, all but three can be fixed at typical values, leading to a nonlinear diffusion problem we linearize and solve exactly with a scaling

  18. Morphology modification of perovskite film by a simple post-treatment process in perovskite solar cell

    Energy Technology Data Exchange (ETDEWEB)

    Song, J.; Yang, Y.; Zhao, Y.L., E-mail: sdyulong@cumt.edu.cn; Che, M.; Zhu, L.; Gu, X.Q.; Qiang, Y.H., E-mail: yhqiang@cumt.edu.cn

    2017-03-15

    Highlights: • Perovskite films were post-treated by DMF/CBZ, DMSO/CBZ, or GBL/CBZ blend solvents. • This process could repair pinholes and enhance coverage in perovskite film. • This technique could modify charge transfer process at TiO{sub 2}/perovskite interface. - Abstract: A homogenous perovskite thin film with high coverage is a determining factor for high performance perovskite solar cells. Unlike previous pre-treatments aiming at perovskite precursor, we proposed a simple method to modify the morphology of perovskite films by post-treatment process using mixed solvents of N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), or 1,4-butyrolactone (GBL) with chlorobenzene (CBZ) in this paper. As good solvent of perovskite, DMF, DMSO, and GBL could dissolve the formed perovskite film. Meanwhile, CBZ, anti-solvent of perovskite film, could decrease the dissolving capacity of these good solvents. Therefore, the perovskite film coverage might be improved by the partial dissolution and recrystallization after solvent post-treatment process. Electrochemical impedance spectrometry (EIS) and time-resolved photoluminescence (TRPL) indicated that this post-treatment process could enhance charge transfer at TiO{sub 2}/perovskite interface. Finally, the conversion efficiency increased from 10.10% to 11.82%, 11.68%, and 10.66% using perovskite films post-treated by DMF/CBZ, DMSO/CBZ, and GBL/CBZ blend solvents, respectively.

  19. Seasonal Synchronization of a Simple Stochastic Dynamical Model Capturing El Niño Diversity

    Science.gov (United States)

    Thual, S.; Majda, A.; Chen, N.

    2017-12-01

    The El Niño-Southern Oscillation (ENSO) has significant impact on global climate and seasonal prediction. Recently, a simple ENSO model was developed that automatically captures the ENSO diversity and intermittency in nature, where state-dependent stochastic wind bursts and nonlinear advection of sea surface temperature (SST) are coupled to simple ocean-atmosphere processes that are otherwise deterministic, linear and stable. In the present article, it is further shown that the model can reproduce qualitatively the ENSO synchronization (or phase-locking) to the seasonal cycle in nature. This goal is achieved by incorporating a cloud radiative feedback that is derived naturally from the model's atmosphere dynamics with no ad-hoc assumptions and accounts in simple fashion for the marked seasonal variations of convective activity and cloud cover in the eastern Pacific. In particular, the weak convective response to SSTs in boreal fall favors the eastern Pacific warming that triggers El Niño events while the increased convective activity and cloud cover during the following spring contributes to the shutdown of those events by blocking incoming shortwave solar radiations. In addition to simulating the ENSO diversity with realistic non-Gaussian statistics in different Niño regions, both the eastern Pacific moderate and super El Niño, the central Pacific El Niño as well as La Niña show a realistic chronology with a tendency to peak in boreal winter as well as decreased predictability in spring consistent with the persistence barrier in nature. The incorporation of other possible seasonal feedbacks in the model is also documented for completeness.

  20. Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors

    Directory of Open Access Journals (Sweden)

    Lough John W

    2010-08-01

    Full Text Available Abstract Background The use of lentiviruses to reprogram human somatic cells into induced pluripotent stem (iPS cells could limit their therapeutic usefulness due to the integration of viral DNA sequences into the genome of the recipient cell. Recent work has demonstrated that human iPS cells can be generated using episomal plasmids, excisable transposons, adeno or sendai viruses, mRNA, or recombinant proteins. While these approaches offer an advance, the protocols have some drawbacks. Commonly the procedures require either subcloning to identify human iPS cells that are free of exogenous DNA, a knowledge of virology and safe handling procedures, or a detailed understanding of protein biochemistry. Results Here we report a simple approach that facilitates the reprogramming of human somatic cells using standard techniques to transfect expression plasmids that encode OCT4, NANOG, SOX2, and LIN28 without the need for episomal stability or selection. The resulting human iPS cells are free of DNA integration, express pluripotent markers, and form teratomas in immunodeficient animals. These iPS cells were also able to undergo directed differentiation into hepatocyte-like and cardiac myocyte-like cells in culture. Conclusions Simple transient transfection of plasmid DNA encoding reprogramming factors is sufficient to generate human iPS cells from primary fibroblasts that are free of exogenous DNA integrations. This approach is highly accessible and could expand the use of iPS cells in the study of human disease and development.

  1. Impact of an observational time window on coupled data assimilation: simulation with a simple climate model

    Directory of Open Access Journals (Sweden)

    Y. Zhao

    2017-11-01

    Full Text Available Climate signals are the results of interactions of multiple timescale media such as the atmosphere and ocean in the coupled earth system. Coupled data assimilation (CDA pursues balanced and coherent climate analysis and prediction initialization by incorporating observations from multiple media into a coupled model. In practice, an observational time window (OTW is usually used to collect measured data for an assimilation cycle to increase observational samples that are sequentially assimilated with their original error scales. Given different timescales of characteristic variability in different media, what are the optimal OTWs for the coupled media so that climate signals can be most accurately recovered by CDA? With a simple coupled model that simulates typical scale interactions in the climate system and twin CDA experiments, we address this issue here. Results show that in each coupled medium, an optimal OTW can provide maximal observational information that best fits the characteristic variability of the medium during the data blending process. Maintaining correct scale interactions, the resulting CDA improves the analysis of climate signals greatly. These simple model results provide a guideline for when the real observations are assimilated into a coupled general circulation model for improving climate analysis and prediction initialization by accurately recovering important characteristic variability such as sub-diurnal in the atmosphere and diurnal in the ocean.

  2. Highly sensitive determination of copper in HeLa cell using capillary electrophoresis combined with a simple cell extraction treatment.

    Science.gov (United States)

    Meng, Lingchen; Fang, Ziyuan; Lin, Jian; Li, Meixian; Zhu, Zhiwei

    2014-04-01

    A new separation system of capillary electrophoresis (CE1) for the highly sensitive determination of copper was established by using ethylenediaminetetraacetic acid (EDTA) as a complexing agent and employing cetyltrimethylammonium chloride (CTAC) as a capillary inner wall modifier. Benefitted from the combination of field-enhanced sample injection (FESI) method, a limit of detection (LOD) of 2.7 nM was obtained, which was much lower than that of the conventional methods. This made it possible to determine trace copper in HeLa cell only by a simple cell extraction (CE2) treatment. Two copper-extraction methods-acid-hydrolysis and freeze-thaw-were compared. Limited by the requirement of low ion strength in FESI, only the extract using freeze-thaw could be successfully applied in the determination. The effectiveness assessment of this CE(2)-FESI method was adopted by inductively coupled plasma-atomic emission spectrometry (ICP-AES) as a gold standard. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. Simple Machines Made Simple.

    Science.gov (United States)

    St. Andre, Ralph E.

    Simple machines have become a lost point of study in elementary schools as teachers continue to have more material to cover. This manual provides hands-on, cooperative learning activities for grades three through eight concerning the six simple machines: wheel and axle, inclined plane, screw, pulley, wedge, and lever. Most activities can be…

  4. Chiral and color-superconducting phase transitions with vector interaction in a simple model

    International Nuclear Information System (INIS)

    Kitazawa, Masakiyo; Koide, Tomoi; Kunihiro, Teiji; Nemoto, Yukio

    2002-01-01

    We investigate effects of the vector interaction on chiral and color superconducting (CSC) phase transitions at finite density and temperature in a simple Nambu-Jona-Lasinio model. It is shown that the repulsive density-density interaction coming from the vector term, which is present in the effective chiral models but has been omitted, enhances the competition between the chiral symmetry breaking (χSB) and CSC phase transition, and thereby makes the thermodynamic potential have a shallow minimum over a wide range of values of the correlated chiral and CSC order parameters. We find that when the vector coupling is increased, the first order transition between the χSB and CSC phases becomes weaker, and the coexisting phase in which both the chiral and color-gauge symmetry are dynamically broken comes to exist over a wider range of the density and temperature. We also show that there can exist two endpoints, which are tricritical points in the chiral limit, along the critical line of the first order transition in some range of values of the vector coupling. Although our analysis is based on a simple model, the nontrivial interplay between the χSB and CSC phases induced by the vector interaction is expected to be a universal phenomenon and might give a clue to understanding results obtained with two-color QCD on the lattice. (author)

  5. Influence of pH on Drug Absorption from the Gastrointestinal Tract: A Simple Chemical Model

    Science.gov (United States)

    Hickman, Raymond J. S.; Neill, Jane

    1997-07-01

    A simple model of the gastrointestinal tract is obtained by placing ethyl acetate in contact with water at pH 2 and pH 8 in separate test tubes. The ethyl acetate corresponds to the lipid material lining the tract while the water corresponds to the aqueous contents of the stomach (pH 2) and intestine (pH 8). The compounds aspirin, paracetamol and 3-aminophenol are used as exemplars of acidic, neutral and basic drugs respectively to illustrate the influence which pH has on the distribution of each class of drug between the aqueous and organic phases of the model. The relative concentration of drug in the ethyl acetate is judged by applying microlitre-sized samples of ethyl acetate to a layer of fluorescent silica which, after evaporation of the ethyl acetate, is viewed under an ultraviolet lamp. Each of the three drugs, if present in the ethyl acetate, becomes visible as a dark spot on the silica layer. The observations made in the model system correspond well to the patterns of drug absorption from the gastrointestinal tract described in pharmacology texts and these observations are convincingly explained in terms of simple acid-base chemistry.

  6. Inferring Soil Moisture Memory from Streamflow Observations Using a Simple Water Balance Model

    Science.gov (United States)

    Orth, Rene; Koster, Randal Dean; Seneviratne, Sonia I.

    2013-01-01

    Soil moisture is known for its integrative behavior and resulting memory characteristics. Soil moisture anomalies can persist for weeks or even months into the future, making initial soil moisture a potentially important contributor to skill in weather forecasting. A major difficulty when investigating soil moisture and its memory using observations is the sparse availability of long-term measurements and their limited spatial representativeness. In contrast, there is an abundance of long-term streamflow measurements for catchments of various sizes across the world. We investigate in this study whether such streamflow measurements can be used to infer and characterize soil moisture memory in respective catchments. Our approach uses a simple water balance model in which evapotranspiration and runoff ratios are expressed as simple functions of soil moisture; optimized functions for the model are determined using streamflow observations, and the optimized model in turn provides information on soil moisture memory on the catchment scale. The validity of the approach is demonstrated with data from three heavily monitored catchments. The approach is then applied to streamflow data in several small catchments across Switzerland to obtain a spatially distributed description of soil moisture memory and to show how memory varies, for example, with altitude and topography.

  7. Simple variational ground state and pure-cat-state generation in the quantum Rabi model

    Science.gov (United States)

    Leroux, C.; Govia, L. C. G.; Clerk, A. A.

    2017-10-01

    We introduce a simple, physically motivated variational ground state for the quantum Rabi model and demonstrate that it provides a high-fidelity approximation of the true ground state in all parameter regimes (including intermediate- and strong-coupling regimes). Our variational state is constructed using Gaussian cavity states and nonorthogonal qubit pointer states and contains only three variational parameters. We use our state to develop a heuristic understanding of how the ground state evolves with increasing coupling and find a parameter regime where the ground state corresponds to the cavity being in a nearly pure Schrödinger cat state.

  8. Competition and fragmentation: a simple model generating lognormal-like distributions

    International Nuclear Information System (INIS)

    Schwaemmle, V; Queiros, S M D; Brigatti, E; Tchumatchenko, T

    2009-01-01

    The current distribution of language size in terms of speaker population is generally described using a lognormal distribution. Analyzing the original real data we show how the double-Pareto lognormal distribution can give an alternative fit that indicates the existence of a power law tail. A simple Monte Carlo model is constructed based on the processes of competition and fragmentation. The results reproduce the power law tails of the real distribution well and give better results for a poorly connected topology of interactions.

  9. Kinetic theory model for the flow of a simple gas from a two-dimensional nozzle

    Science.gov (United States)

    Riley, B. R.; Scheller, K. W.

    1989-01-01

    A system of nonlinear integral equations equivalent to the Krook kinetic equation for the steady state is the mathematical basis used to develop a computer code to model the flowfields for low-thrust two-dimensional nozzles. The method of characteristics was used to solve numerically by an iteration process the approximated Boltzmann equation for the number density, temperature, and velocity profiles of a simple gas as it exhausts into a vacuum. Results predict backscatter and show the effect of the inside wall boundary layer on the flowfields external to the nozzle.

  10. Evaluating the performance of simple estimators for probit models with two dummy endogenous regressors

    DEFF Research Database (Denmark)

    Holm, Anders; Nielsen, Jacob Arendt

    2013-01-01

    This study considers the small sample performance of approximate but simple two-stage estimators for probit models with two endogenous binary covariates. Monte Carlo simulations showthat all the considered estimators, including the simulated maximum-likelihood (SML) estimation, of the trivariate...... for testing the exogeneity of binary covariates. The methods are used to estimate the impact of employment-based health insurance and health care (HC) on HC use, where the approximations seem to work at least as well as the SML and in some cases better....

  11. Lower bounds for ν and Q2 values leading to scaling in the simple parton model

    International Nuclear Information System (INIS)

    Nataf, R.S.

    1979-06-01

    The simple parton model leads to the Bjorken scaling law only for rather large values of the transfer. For small values, the scale invariance is broken by a purely kinematical effect which is shown to depend on: (1+(4M 2 x 2 /Q 2 ))sup(1/2)-1, M being the mass of the target nucleon. Thus, one has to consider: ν>=5M (5GeV) and: Q 2 >=10M 2 x (9GeV/c) 2 for the whole x range) if it is demanded that scaling holds within 10% to error

  12. A simple model of liquid-crystalline magnetic suspension of anisometric particles

    Energy Technology Data Exchange (ETDEWEB)

    Zakhlevnykh, A.N., E-mail: anz@psu.ru; Lubnin, M.S.; Petrov, D.A.

    2017-06-01

    On the base of molecular-statistical approach we study the phase transition between the ordered (ferromagnetic) and disordered (paramagnetic) phases in liquid-crystalline suspensions of magnetic nanoparticles in an external magnetic field. The free energy and equations of magnetic and orientational equilibrium are obtained in the framework of spherical approximation. - Highlights: • We propose a simple statistical model of ferronematic liquid crystals. • We use spherical approximation to derive equations of state. • We study magnetic field induced order-disorder transitions.

  13. A simple fibril and lectin model for cyst walls of Entamoeba and perhaps Giardia

    Science.gov (United States)

    Samuelson, John; Robbins, Phillips

    2010-01-01

    Cyst walls of Entamoeba and Giardia protect them from environmental insults, stomach acids, and intestinal proteases. Each cyst wall contains a sugar homopolymer: chitin in Entamoeba and a unique N-acetylgalactosamine (GalNAc) homopolymer in Giardia. Entamoeba cyst wall proteins include Jacob lectins (carbohydrate-binding proteins) that cross-link chitin, chitinases that degrade chitin, and Jessie lectins that make walls impermeable. Giardia cyst wall proteins are also lectins that bind fibrils of the GalNAc homopolymer. While many of the details remain to be determined for the Giardia cyst wall, current data suggests a relatively simple fibril and lectin model for the Entamoeba cyst wall. PMID:20934911

  14. Exploring the role of internal friction in the dynamics of unfolded proteins using simple polymer models

    Science.gov (United States)

    Cheng, Ryan R.; Hawk, Alexander T.; Makarov, Dmitrii E.

    2013-02-01

    Recent experiments showed that the reconfiguration dynamics of unfolded proteins are often adequately described by simple polymer models. In particular, the Rouse model with internal friction (RIF) captures internal friction effects as observed in single-molecule fluorescence correlation spectroscopy (FCS) studies of a number of proteins. Here we use RIF, and its non-free draining analog, Zimm model with internal friction, to explore the effect of internal friction on the rate with which intramolecular contacts can be formed within the unfolded chain. Unlike the reconfiguration times inferred from FCS experiments, which depend linearly on the solvent viscosity, the first passage times to form intramolecular contacts are shown to display a more complex viscosity dependence. We further describe scaling relationships obeyed by contact formation times in the limits of high and low internal friction. Our findings provide experimentally testable predictions that can serve as a framework for the analysis of future studies of contact formation in proteins.

  15. Dynamics and forecast in a simple model of sustainable development for rural populations.

    Science.gov (United States)

    Angulo, David; Angulo, Fabiola; Olivar, Gerard

    2015-02-01

    Society is becoming more conscious on the need to preserve the environment. Sustainable development schemes have grown rapidly as a tool for managing, predicting and improving the growth path in different regions and economy sectors. We introduce a novel and simple mathematical model of ordinary differential equations (ODEs) in order to obtain a dynamical description for each one of the sustainability components (economy, social development and environment conservation), together with their dependence with demographic dynamics. The main part in the modeling task is inspired by the works by Cobb, Douglas, Brander and Taylor. This is completed through some new insights by the authors. A model application is presented for three specific geographical rural regions in Caldas (Colombia).

  16. A simple mathematical model to predict sea surface temperature over the northwest Indian Ocean

    Science.gov (United States)

    Noori, Roohollah; Abbasi, Mahmud Reza; Adamowski, Jan Franklin; Dehghani, Majid

    2017-10-01

    A novel and simple mathematical model was developed in this study to enhance the capacity of a reduced-order model based on eigenvectors (RMEV) to predict sea surface temperature (SST) in the northwest portion of the Indian Ocean, including the Persian and Oman Gulfs and Arabian Sea. Developed using only the first two of 12,416 possible modes, the enhanced RMEV closely matched observed daily optimum interpolation SST (DOISST) values. Spatial distribution of the first mode indicated the greatest variations in DOISST occurred in the Persian Gulf. Also, the slightly increasing trend in the temporal component of the first mode observed in the study area over the last 34 years properly reflected the impact of climate change and rising DOISST. Given its simplicity and high level of accuracy, the enhanced RMEV can be applied to forecast DOISST in oceans, which the poor forecasting performance and large computational-time of other numerical models may not allow.

  17. A Simple Model of Fields Including the Strong or Nuclear Force and a Cosmological Speculation

    Directory of Open Access Journals (Sweden)

    David L. Spencer

    2016-10-01

    Full Text Available Reexamining the assumptions underlying the General Theory of Relativity and calling an object's gravitational field its inertia, and acceleration simply resistance to that inertia, yields a simple field model where the potential (kinetic energy of a particle at rest is its capacity to move itself when its inertial field becomes imbalanced. The model then attributes electromagnetic and strong forces to the effects of changes in basic particle shape. Following up on the model's assumption that the relative intensity of a particle's gravitational field is always inversely related to its perceived volume and assuming that all black holes spin, may create the possibility of a cosmic rebound where a final spinning black hole ends with a new Big Bang.

  18. Mechanochemical pattern formation in simple models of active viscoelastic fluids and solids

    International Nuclear Information System (INIS)

    Alonso, Sergio; Radszuweit, Markus; Engel, Harald; Bär, Markus

    2017-01-01

    The cytoskeleton of the organism Physarum polycephalum is a prominent example of a complex active viscoelastic material wherein stresses induce flows along the organism as a result of the action of molecular motors and their regulation by calcium ions. Experiments in Physarum polycephalum have revealed a rich variety of mechanochemical patterns including standing, traveling and rotating waves that arise from instabilities of spatially homogeneous states without gradients in stresses and resulting flows. Herein, we investigate simple models where an active stress induced by molecular motors is coupled to a model describing the passive viscoelastic properties of the cellular material. Specifically, two models for viscoelastic fluids (Maxwell and Jeffrey model) and two models for viscoelastic solids (Kelvin–Voigt and Standard model) are investigated. Our focus is on the analysis of the conditions that cause destabilization of spatially homogeneous states and the related onset of mechano-chemical waves and patterns. We carry out linear stability analyses and numerical simulations in one spatial dimension for different models. In general, sufficiently strong activity leads to waves and patterns. The primary instability is stationary for all active fluids considered, whereas all active solids have an oscillatory primary instability. All instabilities found are of long-wavelength nature reflecting the conservation of the total calcium concentration in the models studied. (paper)

  19. A simple model for the evolution of melt pond coverage on permeable Arctic sea ice

    Science.gov (United States)

    Popović, Predrag; Abbot, Dorian

    2017-05-01

    As the melt season progresses, sea ice in the Arctic often becomes permeable enough to allow for nearly complete drainage of meltwater that has collected on the ice surface. Melt ponds that remain after drainage are hydraulically connected to the ocean and correspond to regions of sea ice whose surface is below sea level. We present a simple model for the evolution of melt pond coverage on such permeable sea ice floes in which we allow for spatially varying ice melt rates and assume the whole floe is in hydrostatic balance. The model is represented by two simple ordinary differential equations, where the rate of change of pond coverage depends on the pond coverage. All the physical parameters of the system are summarized by four strengths that control the relative importance of the terms in the equations. The model both fits observations and allows us to understand the behavior of melt ponds in a way that is often not possible with more complex models. Examples of insights we can gain from the model are that (1) the pond growth rate is more sensitive to changes in bare sea ice albedo than changes in pond albedo, (2) ponds grow slower on smoother ice, and (3) ponds respond strongest to freeboard sinking on first-year ice and sidewall melting on multiyear ice. We also show that under a global warming scenario, pond coverage would increase, decreasing the overall ice albedo and leading to ice thinning that is likely comparable to thinning due to direct forcing. Since melt pond coverage is one of the key parameters controlling the albedo of sea ice, understanding the mechanisms that control the distribution of pond coverage will help improve large-scale model parameterizations and sea ice forecasts in a warming climate.

  20. Stochastic models of cell motility

    DEFF Research Database (Denmark)

    Gradinaru, Cristian

    2012-01-01

    Cell motility and migration are central to the development and maintenance of multicellular organisms, and errors during this process can lead to major diseases. Consequently, the mechanisms and phenomenology of cell motility are currently under intense study. In recent years, a new...... interdisciplinary field focusing on the study of biological processes at the nanoscale level, with a range of technological applications in medicine and biological research, has emerged. The work presented in this thesis is at the interface of cell biology, image processing, and stochastic modeling. The stochastic...... models introduced here are based on persistent random motion, which I apply to real-life studies of cell motility on flat and nanostructured surfaces. These models aim to predict the time-dependent position of cell centroids in a stochastic manner, and conversely determine directly from experimental...

  1. Gaseous VOCs rapidly modify particulate matter and its biological effects - Part 1: Simple VOCs and model PM

    Science.gov (United States)

    Ebersviller, S.; Lichtveld, K.; Sexton, K. G.; Zavala, J.; Lin, Y.-H.; Jaspers, I.; Jeffries, H. E.

    2012-12-01

    This is the first of a three-part study designed to demonstrate dynamic entanglements among gaseous organic compounds (VOC), particulate matter (PM), and their subsequent potential biological effects. We study these entanglements in increasingly complex VOC and PM mixtures in urban-like conditions in a large outdoor chamber. To the traditional chemical and physical characterizations of gas and PM, we added new measurements of biological effects, using cultured human lung cells as model indicators. These biological effects are assessed here as increases in cellular damage or expressed irritation (i.e., cellular toxic effects) from cells exposed to chamber air relative to cells exposed to clean air. The exposure systems permit virtually gas-only- or PM-only-exposures from the same air stream containing both gases and PM in equilibria, i.e., there are no extractive operations prior to cell exposure. Our simple experiments in this part of the study were designed to eliminate many competing atmospheric processes to reduce ambiguity in our results. Simple volatile and semi-volatile organic gases that have inherent cellular toxic properties were tested individually for biological effect in the dark (at constant humidity). Airborne mixtures were then created with each compound to which we added PM that has no inherent cellular toxic properties for another cellular exposure. Acrolein and p-tolualdehyde were used as model VOCs and mineral oil aerosol (MOA) was selected as a surrogate for organic-containing PM. MOA is appropriately complex in composition to represent ambient PM, and exhibits no inherent cellular toxic effects and thus did not contribute any biological detrimental effects on its own. Chemical measurements, combined with the responses of our biological exposures, clearly demonstrate that gas-phase pollutants can modify the composition of PM (and its resulting detrimental effects on lung cells). We observed that, even if the gas-phase pollutants are not

  2. Simple and reliable procedure for PCR amplification of genomic DNA from yeast cells using short sequencing primers

    DEFF Research Database (Denmark)

    Haaning, J; Oxvig, C; Overgaard, Michael Toft

    1997-01-01

    by means of PCR without any prior DNA purification steps. This method involves a simple boiling step of whole yeast cells in the presence of detergent, and subsequent amplification of genomic DNA using short sequencing primers in a polymerase chain reaction assay with a decreasing annealing temperature...

  3. Simple Models for Model-based Portfolio Load Balancing Controller Synthesis

    DEFF Research Database (Denmark)

    Edlund, Kristian Skjoldborg; Mølbak, Tommy; Bendtsen, Jan Dimon

    2010-01-01

    This paper presents a collection of models of so-called 'effectuators', i.e., subsystems in a power plant portfolio that represent control actions with associated dynamics and actuation costs. These models are derived in order to facilitate higher-level model-based control synthesis of a portfolio...... of generation units existing in an electrical power supply network, for instance in model-based predictive control or declarative control schemes. We focus on the effectuators found in the Danish power system. In particular, the paper presents models for boiler load, district heating, condensate throttling...... and wind turbine effectuators. Each model is validated against actual measurement data. Considering their simplicity, the models fit the observed data very well and are thus suitable for control purposes....

  4. A Sound Processor for Cochlear Implant Using a Simple Dual Path Nonlinear Model of Basilar Membrane

    Directory of Open Access Journals (Sweden)

    Kyung Hwan Kim

    2013-01-01

    Full Text Available We propose a new active nonlinear model of the frequency response of the basilar membrane in biological cochlea called the simple dual path nonlinear (SDPN model and a novel sound processing strategy for cochlear implants (CIs based upon this model. The SDPN model was developed to utilize the advantages of the level-dependent frequency response characteristics of the basilar membrane for robust formant representation under noisy conditions. In comparison to the dual resonance nonlinear model (DRNL which was previously proposed as an active nonlinear model of the basilar membrane, the SDPN model can reproduce similar level-dependent frequency responses with a much simpler structure and is thus better suited for incorporation into CI sound processors. By the analysis of dominant frequency component, it was confirmed that the formants of speech are more robustly represented after frequency decomposition by the nonlinear filterbank using SDPN, compared to a linear bandpass filter array which is used in conventional strategies. Acoustic simulation and hearing experiments in subjects with normal hearing showed that the proposed strategy results in better syllable recognition under speech-shaped noise compared to the conventional strategy based on fixed linear bandpass filters.

  5. A simple model of the effect of ocean ventilation on ocean heat uptake

    Energy Technology Data Exchange (ETDEWEB)

    Nadiga, Balasubramanya T. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Urban, Nathan Mark [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-01-27

    Presentation includes slides on Earth System Models vs. Simple Climate Models; A Popular SCM: Energy Balance Model of Anomalies; On calibrating against one ESM experiment, the SCM correctly captures that ESM's surface warming response with other forcings; Multi-Model Analysis: Multiple ESMs, Single SCM; Posterior Distributions of ECS; However In Excess of 90% of TOA Energy Imbalance is Sequestered in the World Oceans; Heat Storage in the Two Layer Model; Heat Storage in the Two Layer Model; Including TOA Rad. Imbalance and Ocean Heat in Calibration Improves Repr., but Significant Errors Persist; Improved Vertical Resolution Does Not Fix Problem; A Series of Expts. Confirms That Anomaly-Diffusing Models Cannot Properly Represent Ocean Heat Uptake; Physics of the Thermocline; Outcropping Isopycnals and Horizontally-Averaged Layers; Local interactions between outcropping isopycnals leads to non-local interactions between horizontally-averaged layers; Both Surface Warming and Ocean Heat are Well Represented With Just 4 Layers; A Series of Expts. Confirms That When Non-Local Interactions are Allowed, the SCMs Can Represent Both Surface Warming and Ocean Heat Uptake; and Summary and Conclusions.

  6. A simple parametric model observer for quality assurance in computer tomography

    Science.gov (United States)

    Anton, M.; Khanin, A.; Kretz, T.; Reginatto, M.; Elster, C.

    2018-04-01

    Model observers are mathematical classifiers that are used for the quality assessment of imaging systems such as computer tomography. The quality of the imaging system is quantified by means of the performance of a selected model observer. For binary classification tasks, the performance of the model observer is defined by the area under its ROC curve (AUC). Typically, the AUC is estimated by applying the model observer to a large set of training and test data. However, the recording of these large data sets is not always practical for routine quality assurance. In this paper we propose as an alternative a parametric model observer that is based on a simple phantom, and we provide a Bayesian estimation of its AUC. It is shown that a limited number of repeatedly recorded images (10–15) is already sufficient to obtain results suitable for the quality assessment of an imaging system. A MATLAB® function is provided for the calculation of the results. The performance of the proposed model observer is compared to that of the established channelized Hotelling observer and the nonprewhitening matched filter for simulated images as well as for images obtained from a low-contrast phantom on an x-ray tomography scanner. The results suggest that the proposed parametric model observer, along with its Bayesian treatment, can provide an efficient, practical alternative for the quality assessment of CT imaging systems.

  7. A simple parametric model observer for quality assurance in computer tomography.

    Science.gov (United States)

    Anton, Mathias; Khanin, Alexander; Kretz, Tobias; Reginatto, Marcel; Elster, Clemens

    2018-02-26

    Model observers are mathematical classifiers that are used for the quality assessment of imaging systems such as computer tomography. The quality of the imaging system is quantified by means of the performance of a selected model observer. For binary classification tasks, the performance of the model observer is defined by the area under its ROC curve (AUC). Typically, the AUC is estimated by applying the model observer to a large set of training and test data. However, the recording of these large data sets is not always practical for routine quality assurance. In this paper we propose as an alternative a parametric model observer that is based on a simple phantom, and we provide a Bayesian estimation of its AUC. It is shown that a limited number of repeatedly recorded images (10-15) is already sufficient to obtain results suitable for the quality assessment of an imaging system. A MATLAB® function is provided for the calculation of the results. The performance of the proposed model observer is compared to that of the established channelized Hotelling observer (CHO) and the nonprewhitening matched filter (NPW) for simulated images as well as for images obtained from a low-contrast phantom on an x-ray tomography scanner. The results suggest that the proposed parametric model observer, along with its Bayesian treatment, can provide an efficient, practical alternative for the quality assessment of CT imaging systems. © 2018 Institute of Physics and Engineering in Medicine.

  8. Introduction of a simple-model-based land surface dataset for Europe

    Science.gov (United States)

    Orth, Rene; Seneviratne, Sonia I.

    2015-04-01

    Land surface hydrology can play a crucial role during extreme events such as droughts, floods and even heat waves. We introduce in this study a new hydrological dataset for Europe that consists of soil moisture, runoff and evapotranspiration (ET). It is derived with a simple water balance model (SWBM) forced with precipitation, temperature and net radiation. The SWBM dataset extends over the period 1984-2013 with a daily time step and 0.5° × 0.5° resolution. We employ a novel calibration approach, in which we consider 300 random parameter sets chosen from an observation-based range. Using several independent validation datasets representing soil moisture (or terrestrial water content), ET and streamflow, we identify the best performing parameter set and hence the new dataset. To illustrate its usefulness, the SWBM dataset is compared against several state-of-the-art datasets (ERA-Interim/Land, MERRA-Land, GLDAS-2-Noah, simulations of the Community Land Model Version 4), using all validation datasets as reference. For soil moisture dynamics it outperforms the benchmarks. Therefore the SWBM soil moisture dataset constitutes a reasonable alternative to sparse measurements, little validated model results, or proxy data such as precipitation indices. Also in terms of runoff the SWBM dataset performs well, whereas the evaluation of the SWBM ET dataset is overall satisfactory, but the dynamics are less well captured for this variable. This highlights the limitations of the dataset, as it is based on a simple model that uses uniform parameter values. Hence some processes impacting ET dynamics may not be captured, and quality issues may occur in regions with complex terrain. Even though the SWBM is well calibrated, it cannot replace more sophisticated models; but as their calibration is a complex task the present dataset may serve as a benchmark in future. In addition we investigate the sources of skill of the SWBM dataset and find that the parameter set has a similar

  9. HIV Treatment and Prevention: A Simple Model to Determine Optimal Investment.

    Science.gov (United States)

    Juusola, Jessie L; Brandeau, Margaret L

    2016-04-01

    To create a simple model to help public health decision makers determine how to best invest limited resources in HIV treatment scale-up and prevention. A linear model was developed for determining the optimal mix of investment in HIV treatment and prevention, given a fixed budget. The model incorporates estimates of secondary health benefits accruing from HIV treatment and prevention and allows for diseconomies of scale in program costs and subadditive benefits from concurrent program implementation. Data sources were published literature. The target population was individuals infected with HIV or at risk of acquiring it. Illustrative examples of interventions include preexposure prophylaxis (PrEP), community-based education (CBE), and antiretroviral therapy (ART) for men who have sex with men (MSM) in the US. Outcome measures were incremental cost, quality-adjusted life-years gained, and HIV infections averted. Base case analysis indicated that it is optimal to invest in ART before PrEP and to invest in CBE before scaling up ART. Diseconomies of scale reduced the optimal investment level. Subadditivity of benefits did not affect the optimal allocation for relatively low implementation levels. The sensitivity analysis indicated that investment in ART before PrEP was optimal in all scenarios tested. Investment in ART before CBE became optimal when CBE reduced risky behavior by 4% or less. Limitations of the study are that dynamic effects are approximated with a static model. Our model provides a simple yet accurate means of determining optimal investment in HIV prevention and treatment. For MSM in the US, HIV control funds should be prioritized on inexpensive, effective programs like CBE, then on ART scale-up, with only minimal investment in PrEP. © The Author(s) 2015.

  10. A simple iterative method for estimating evapotranspiration with integrated surface/subsurface flow models

    Science.gov (United States)

    Hwang, H.-T.; Park, Y.-J.; Frey, S. K.; Berg, S. J.; Sudicky, E. A.

    2015-12-01

    This work presents an iterative, water balance based approach to estimate actual evapotranspiration (ET) with integrated surface/subsurface flow models. Traditionally, groundwater level fluctuation methods have been widely accepted and used for estimating ET and net groundwater recharge; however, in watersheds where interactions between surface and subsurface flow regimes are highly dynamic, the traditional method may be overly simplistic. Here, an innovative methodology is derived and demonstrated for using the water balance equation in conjunction with a fully-integrated surface and subsurface hydrologic model (HydroGeoSphere) in order to estimate ET at watershed and sub-watershed scales. The method invokes a simple and robust iterative numerical solution. For the proof of concept demonstrations, the method is used to estimate ET for a simple synthetic watershed and then for a real, highly-characterized 7000 km2 watershed in Southern Ontario, Canada (Grand River Watershed). The results for the Grand River Watershed show that with three to five iterations, the solution converges to a result where there is less than 1% relative error in stream flow calibration at 16 stream gauging stations. The spatially-averaged ET estimated using the iterative method shows a high level of agreement (R2 = 0.99) with that from a benchmark case simulated with an ET model embedded directly in HydroGeoSphere. The new approach presented here is applicable to any watershed that is suited for integrated surface water/groundwater flow modelling and where spatially-averaged ET estimates are useful for calibrating modelled stream discharge.

  11. A simple and novel modification of comet assay for determination of bacteriophage mediated bacterial cell lysis.

    Science.gov (United States)

    Khairnar, Krishna; Sanmukh, Swapnil; Chandekar, Rajshree; Paunikar, Waman

    2014-07-01

    The comet assay is the widely used method for in vitro toxicity testing which is also an alternative to the use of animal models for in vivo testing. Since, its inception in 1984 by Ostling and Johansson, it is being modified frequently for a wide range of application. In spite of its wide applicability, unfortunately there is no report of its application in bacteriophages research. In this study, a novel application of comet assay for the detection of bacteriophage mediated bacterial cell lysis was described. The conventional methods in bacteriophage research for studying bacterial lysis by bacteriophages are plaque assay method. It is time consuming, laborious and costly. The lytic activity of bacteriophage devours the bacterial cell which results in the release of bacterial genomic material that gets detected by ethidium bromide staining method by the comet assay protocol. The objective of this study was to compare efficacy of comet assay with different assay used to study phage mediated bacterial lysis. The assay was performed on culture isolates (N=80 studies), modified comet assay appear to have relatively higher sensitivity and specificity than other assay. The results of the study showed that the application of comet assay can be an economical, time saving and less laborious alternative to conventional plaque assay for the detection of bacteriophage mediated bacterial cell lysis. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Uncertainty analysis on simple mass balance model to calculate critical loads for soil acidity

    International Nuclear Information System (INIS)

    Li Harbin; McNulty, Steven G.

    2007-01-01

    Simple mass balance equations (SMBE) of critical acid loads (CAL) in forest soil were developed to assess potential risks of air pollutants to ecosystems. However, to apply SMBE reliably at large scales, SMBE must be tested for adequacy and uncertainty. Our goal was to provide a detailed analysis of uncertainty in SMBE so that sound strategies for scaling up CAL estimates to the national scale could be developed. Specifically, we wanted to quantify CAL uncertainty under natural variability in 17 model parameters, and determine their relative contributions in predicting CAL. Results indicated that uncertainty in CAL came primarily from components of base cation weathering (BC w ; 49%) and acid neutralizing capacity (46%), whereas the most critical parameters were BC w base rate (62%), soil depth (20%), and soil temperature (11%). Thus, improvements in estimates of these factors are crucial to reducing uncertainty and successfully scaling up SMBE for national assessments of CAL. - A comprehensive uncertainty analysis, with advanced techniques and full list and full value ranges of all individual parameters, was used to examine a simple mass balance model and address questions of error partition and uncertainty reduction in critical acid load estimates that were not fully answered by previous studies

  13. The attentional drift-diffusion model extends to simple purchasing decisions.

    Science.gov (United States)

    Krajbich, Ian; Lu, Dingchao; Camerer, Colin; Rangel, Antonio

    2012-01-01

    How do we make simple purchasing decisions (e.g., whether or not to buy a product at a given price)? Previous work has shown that the attentional drift-diffusion model (aDDM) can provide accurate quantitative descriptions of the psychometric data for binary and trinary value-based choices, and of how the choice process is guided by visual attention. Here we extend the aDDM to the case of purchasing decisions, and test it using an eye-tracking experiment. We find that the model also provides a reasonably accurate quantitative description of the relationship between choice, reaction time, and visual fixations using parameters that are very similar to those that best fit the previous data. The only critical difference is that the choice biases induced by the fixations are about half as big in purchasing decisions as in binary choices. This suggests that a similar computational process is used to make binary choices, trinary choices, and simple purchasing decisions.

  14. A Simple Geometrical Model for Calculation of the Effective Emissivity in Blackbody Cylindrical Cavities

    Science.gov (United States)

    De Lucas, Javier

    2015-03-01

    A simple geometrical model for calculating the effective emissivity in blackbody cylindrical cavities has been developed. The back ray tracing technique and the Monte Carlo method have been employed, making use of a suitable set of coordinates and auxiliary planes. In these planes, the trajectories of individual photons in the successive reflections between the cavity points are followed in detail. The theoretical model is implemented by using simple numerical tools, programmed in Microsoft Visual Basic for Application and Excel. The algorithm is applied to isothermal and non-isothermal diffuse cylindrical cavities with a lid; however, the basic geometrical structure can be generalized to a cylindro-conical shape and specular reflection. Additionally, the numerical algorithm and the program source code can be used, with minor changes, for determining the distribution of the cavity points, where photon absorption takes place. This distribution could be applied to the study of the influence of thermal gradients on the effective emissivity profiles, for example. Validation is performed by analyzing the convergence of the Monte Carlo method as a function of the number of trials and by comparison with published results of different authors.

  15. Biophysical models of transcription in cells

    Science.gov (United States)

    Choubey, Sandeep

    Cells constantly face environmental challenges and deal with them by changing their gene expression patterns. They make decisions regarding which genes to express and which genes not to express based on intra-cellular and environmental cues. These decisions are often made by regulating the process of transcription. While the identities of the different molecules that take part in regulating transcription have been determined for a number of different genes, their dynamics inside the cell are still poorly understood. One key feature of these regulatory dynamics is that the numbers of the bio-molecules involved is typically small, resulting in large temporal fluctuations in transcriptional outputs (mRNA and protein). In this thesis I show that measurements of the cell-to-cell variability of the distribution of transcribing RNA polymerases along a gene provide a previously unexplored method for deciphering the mechanism of its transcription in vivo. First, I propose a simple kinetic model of transcription initiation and elongation from which I calculate transcribing RNA polymerase copy-number fluctuations. I test my theory against published data obtained for yeast genes and propose a novel mechanism of transcription. Rather than transcription being initiated through a single rate-limiting step, as was previously proposed, my single-cell analysis reveals the presence of at least two rate limiting steps. Second, I compute the distribution of inter-polymerase distance distribution along a gene and propose a method for analyzing inter-polymerase distance distributions acquired in experiments. By applying this method to images of polymerases transcribing ribosomal genes in E.coli I show that one model of regulation of these genes is consistent with inter-polymerase distance data while a number of other models are not. The analytical framework described in this thesis can be used to extract quantitative information about the dynamics of transcription from single-cell

  16. Simple Scaling of Mulit-Stream Jet Plumes for Aeroacoustic Modeling

    Science.gov (United States)

    Bridges, James

    2016-01-01

    When creating simplified, semi-empirical models for the noise of simple single-stream jets near surfaces it has proven useful to be able to generalize the geometry of the jet plume. Having a model that collapses the mean and turbulent velocity fields for a range of flows allows the problem to become one of relating the normalized jet field and the surface. However, most jet flows of practical interest involve jets of two or more coannular flows for which standard models for the plume geometry do not exist. The present paper describes one attempt to relate the mean and turbulent velocity fields of multi-stream jets to that of an equivalent single-stream jet. The normalization of single-stream jets is briefly reviewed, from the functional form of the flow model to the results of the modeling. Next, PIV data from a number of multi-stream jets is analyzed in a similar fashion. The results of several single-stream approximations of the multi-stream jet plume are demonstrated, with a best approximation determined and the shortcomings of the model highlighted.

  17. Simple Scaling of Multi-Stream Jet Plumes for Aeroacoustic Modeling

    Science.gov (United States)

    Bridges, James

    2015-01-01

    When creating simplified, semi-empirical models for the noise of simple single-stream jets near surfaces it has proven useful to be able to generalize the geometry of the jet plume. Having a model that collapses the mean and turbulent velocity fields for a range of flows allows the problem to become one of relating the normalized jet field and the surface. However, most jet flows of practical interest involve jets of two or more co-annular flows for which standard models for the plume geometry do not exist. The present paper describes one attempt to relate the mean and turbulent velocity fields of multi-stream jets to that of an equivalent single-stream jet. The normalization of single-stream jets is briefly reviewed, from the functional form of the flow model to the results of the modeling. Next, PIV (Particle Image Velocimetry) data from a number of multi-stream jets is analyzed in a similar fashion. The results of several single-stream approximations of the multi-stream jet plume are demonstrated, with a 'best' approximation determined and the shortcomings of the model highlighted.

  18. Crises and Collective Socio-Economic Phenomena: Simple Models and Challenges

    Science.gov (United States)

    Bouchaud, Jean-Philippe

    2013-05-01

    Financial and economic history is strewn with bubbles and crashes, booms and busts, crises and upheavals of all sorts. Understanding the origin of these events is arguably one of the most important problems in economic theory. In this paper, we review recent efforts to include heterogeneities and interactions in models of decision. We argue that the so-called Random Field Ising model ( rfim) provides a unifying framework to account for many collective socio-economic phenomena that lead to sudden ruptures and crises. We discuss different models that can capture potentially destabilizing self-referential feedback loops, induced either by herding, i.e. reference to peers, or trending, i.e. reference to the past, and that account for some of the phenomenology missing in the standard models. We discuss some empirically testable predictions of these models, for example robust signatures of rfim-like herding effects, or the logarithmic decay of spatial correlations of voting patterns. One of the most striking result, inspired by statistical physics methods, is that Adam Smith's invisible hand can fail badly at solving simple coordination problems. We also insist on the issue of time-scales, that can be extremely long in some cases, and prevent socially optimal equilibria from being reached. As a theoretical challenge, the study of so-called "detailed-balance" violating decision rules is needed to decide whether conclusions based on current models (that all assume detailed-balance) are indeed robust and generic.

  19. Evaluation of Turbulence Models Through Predictions of a Simple 3D Boundary Layer.

    Science.gov (United States)

    Jammalamadaka, A.

    2005-11-01

    Although a number of popular turbulence models are now commonly used to predict complex 3D flows, in particular for industrial applications, very limited full evaluation of their performance has been carried out using thoroughly documented experiments. One such experiment is that of Bruns, Fernholz and Monkewitz (JFM, vol. 393; 1999) in a boundary layer on the wall of an S-shaped duct, where the wall shear stress was measured accurately and independently in the original work and more recently with oil-film interferometry by Reudi et al. (Exp Fluids vol. 35; 2003). Results from various models including k-ɛ, Spalart-Alamaras, k-φ, Menter's SST, and RSM are compared with the experimental results to extract better understanding of strengths and limitations of the various models. In addition to the various pressure distributions along the S-duct and the shear stress development on the test surface, the various normal stresses are compared for all the models with some surprising results in reference to the difficulty in predicting even such a simple 3D turbulent flow. Comparisons of other Reynolds stresses with models that predict them directly also reveal interesting results. In general the predictions of models are more in agreement with each other than with the experiment, suggesting that they suffer from common shortcomings. Also, the deviations of the predictions from the experiment grow to significant levels just beyond the development of the cross-over transverse velocity profile.

  20. Do simple models give a correct description of the wind condition in a coastal area ?

    Energy Technology Data Exchange (ETDEWEB)

    Kaellstrand, B. [Uppsala Univ. (Sweden). Dept. of Meteorology

    1996-12-01

    When the surface conditions changes at a coastline, an internal boundary layer evolves, with a wind speed and turbulence intensity influenced by these new conditions. Aircraft measurements across the coastline, performed during near neutral conditions, are compared with a model and thirteen more simple expressions for the growth of an internal boundary layer (IBL). The majority of the expressions overestimate the IBL height, while other underestimate it. Some of the expressions give reasonable result close to the coast. The model gives good agreement, even for larger distances. The vertical potential temperature gradient turned out to be an important parameter for the growth of the IBL, even with this near neutral conditions. 21 refs, 5 figs, 1 tab

  1. A simple 2D SOC model for one of the main sources of geomagnetic disturbances: Flares

    International Nuclear Information System (INIS)

    Meirelles, M.C.; Dias, V.H.A.; Oliva, D.; Papa, A.R.R.

    2010-01-01

    We introduce a simple model for solar flares, one of the main sources of geomagnetic disturbances. We have obtained power-laws for the probability distribution functions of some relevant physical characteristics of flares which could serve as the fingerprint of a critical state at the base of such phenomena and, given that we have not introduced a fine tune mechanism, of self-organized criticality. We compare our results with some recent experimental work on the statistics of flares and analyze the possible connection of these power laws with others already found by our group in geomagnetic disturbances distributions. We also present some limitations of our model as well as possible extensions and corrections to be taken into account in future works.

  2. Simple potential model for interaction of dark particles with massive bodies

    Science.gov (United States)

    Takibayev, Nurgali

    2018-01-01

    A simple model for interaction of dark particles with matter based on resonance behavior in a three-body system is proposed. The model describes resonant amplification of effective interaction between two massive bodies at large distances between them. The phenomenon is explained by catalytic action of dark particles rescattering at a system of two heavy bodies which are understood here as the big stellar objects. Resonant amplification of the effective interaction between the two heavy bodies imitates the increase in their mass while their true gravitational mass remains unchanged. Such increased interaction leads to more pronounced gravitational lensing of bypassing light. It is shown that effective interaction between the heavy bodies is changed at larger distances and can transform into repulsive action.

  3. A Simple Accounting-based Valuation Model for the Debt Tax Shield

    Directory of Open Access Journals (Sweden)

    Andreas Scholze

    2010-05-01

    Full Text Available This paper describes a simple way to integrate the debt tax shield into an accounting-based valuation model. The market value of equity is determined by forecasting residual operating income, which is calculated by charging operating income for the operating assets at a required return that accounts for the tax benefit that comes from borrowing to raise cash for the operations. The model assumes that the firm maintains a deterministic financial leverage ratio, which tends to converge quickly to typical steady-state levels over time. From a practical point of view, this characteristic is of particular help, because it allows a continuing value calculation at the end of a short forecast period.

  4. A simple model for the dispersion of pollutants from a road tunnel portal

    Science.gov (United States)

    Oettl, Dietmar; Sturm, Peter Johann; Bacher, Michael; Pretterhofer, Gerhard; Almbauer, Raimund Alfons

    The dispersion of pollutants from a roadway tunnel portal is mainly determined by the interaction between the ambient wind and the jet stream from the tunnel portal. In principal, Eulerian microscale models by solving the conservation equations for mass, momentum, and energy, are thus able to simulate effects such as buoyancy etc. properly. However, for engineering applications such models need too much CPU time, and are not easy to handle by non-scientific personnel. Only a few dispersion models, applicable for regulatory purposes, have so far appeared in the literature. These models are either empirical models not always applicable for different sites, or they do not capture important physical effects like buoyancy phenomena. Here, a rather simple model is presented, which takes into account most of the important processes considered to govern the dispersion of a jet stream from portals. These are the exit velocity, the buoyancy, the influence of ambient wind direction fluctuations on the position of the jet stream, and traffic induced turbulence. Although the model contains some heuristic elements, it was successfully tested against tracer experiments taken near a motorway tunnel portal in Austria. The model requires relatively little CPU time. Current limitations of the model include the neglect of terrain, building, and vehicle effects on the dispersion, and the neglect of the horizontal dispersion arising from entrainment of ambient air in the jet stream. The latter could lead to an underestimation of plume spreads for higher wind speeds. The validation of the model will be the focus of future research. The experimental data set is also available for the scientific community.

  5. A simple model for predicting soil temperature in snow-covered and seasonally frozen soil: model description and testing

    Directory of Open Access Journals (Sweden)

    K. Rankinen

    2004-01-01

    Full Text Available Microbial processes in soil are moisture, nutrient and temperature dependent and, consequently, accurate calculation of soil temperature is important for modelling nitrogen processes. Microbial activity in soil occurs even at sub-zero temperatures so that, in northern latitudes, a method to calculate soil temperature under snow cover and in frozen soils is required. This paper describes a new and simple model to calculate daily values for soil temperature at various depths in both frozen and unfrozen soils. The model requires four parameters: average soil thermal conductivity, specific heat capacity of soil, specific heat capacity due to freezing and thawing and an empirical snow parameter. Precipitation, air temperature and snow depth (measured or calculated are needed as input variables. The proposed model was applied to five sites in different parts of Finland representing different climates and soil types. Observed soil temperatures at depths of 20 and 50 cm (September 1981–August 1990 were used for model calibration. The calibrated model was then tested using observed soil temperatures from September 1990 to August 2001. R2-values of the calibration period varied between 0.87 and 0.96 at a depth of 20 cm and between 0.78 and 0.97 at 50 cm. R2-values of the testing period were between 0.87 and 0.94 at a depth of 20cm, and between 0.80 and 0.98 at 50cm. Thus, despite the simplifications made, the model was able to simulate soil temperature at these study sites. This simple model simulates soil temperature well in the uppermost soil layers where most of the nitrogen processes occur. The small number of parameters required means that the model is suitable for addition to catchment scale models. Keywords: soil temperature, snow model

  6. Identifying habitats at risk: simple models can reveal complex ecosystem dynamics.

    Science.gov (United States)

    Maxwell, Paul S; Pitt, Kylie A; Olds, Andrew D; Rissik, David; Connolly, Rod M

    2015-03-01

    The relationship between ecological impact and ecosystem structure is often strongly nonlinear, so that small increases in impact levels can cause a disproportionately large response in ecosystem structure. Nonlinear ecosystem responses can be difficult to predict because locally relevant data sets can be difficult or impossible to obtain. Bayesian networks (BN) are an emerging tool that can help managers to define ecosystem relationships using a range of data types from comprehensive quantitative data sets to expert opinion. We show how a simple BN can reveal nonlinear dynamics in seagrass ecosystems using ecological relationships sourced from the literature. We first developed a conceptual diagram by cataloguing the ecological responses of seagrasses to a range of drivers and impacts. We used the conceptual diagram to develop a BN populated with values sourced from published studies. We then applied the BN to show that the amount of initial seagrass biomass has a mitigating effect on the level of impact a meadow can withstand without loss, and that meadow recovery can often require disproportionately large improvements in impact levels. This mitigating effect resulted in the middle ranges of impact levels having a wide likelihood of seagrass presence, a situation known as bistability. Finally, we applied the model in a case study to identify the risk of loss and the likelihood of recovery for the conservation and management of seagrass meadows in Moreton Bay, Queensland, Australia. We used the model to predict the likelihood of bistability in 23 locations in the Bay. The model predicted bistability in seven locations, most of which have experienced seagrass loss at some stage in the past 25 years providing essential information for potential future restoration efforts. Our results demonstrate the capacity of simple, flexible modeling tools to facilitate collation and synthesis of disparate information. This approach can be adopted in the initial stages of

  7. A simple model for the evolution of the dust population in protoplanetary disks

    Science.gov (United States)

    Birnstiel, T.; Klahr, H.; Ercolano, B.

    2012-03-01

    Context. The global size and spatial distribution of dust is an important ingredient in the structure and evolution of protoplanetary disks and in the formation of larger bodies, such as planetesimals. Aims: We aim to derive simple equations that explain the global evolution of the dust surface density profile and the upper limit of the grain size distribution and which can readily be used for further modeling or for interpreting of observational data. Methods: We have developed a simple model that follows the upper end of the dust size distribution and the evolution of the dust surface density profile. This model is calibrated with state-of-the-art simulations of dust evolution, which treat dust growth, fragmentation, and transport in viscously evolving gas disks. Results: We find very good agreement between the full dust-evolution code and the toy model presented in this paper. We derive analytical profiles that describe the dust-to-gas ratios and the dust surface density profiles well in protoplanetary disks, as well as the radial flux by solid material "rain out", which is crucial for triggering any gravity assisted formation of planetesimals. We show that fragmentation is the dominating effect in the inner regions of the disk leading to a dust surface density exponent of -1.5, while the outer regions at later times can become drift-dominated, yielding a dust surface density exponent of -0.75. Our results show that radial drift is not efficient in fragmenting dust grains. This supports the theory that small dust grains are resupplied by fragmentation due to the turbulent state of the disk.

  8. Birth and death of protein domains: A simple model of evolution explains power law behavior

    Directory of Open Access Journals (Sweden)

    Berezovskaya Faina S

    2002-10-01

    Full Text Available Abstract Background Power distributions appear in numerous biological, physical and other contexts, which appear to be fundamentally different. In biology, power laws have been claimed to describe the distributions of the connections of enzymes and metabolites in metabolic networks, the number of interactions partners of a given protein, the number of members in paralogous families, and other quantities. In network analysis, power laws imply evolution of the network with preferential attachment, i.e. a greater likelihood of nodes being added to pre-existing hubs. Exploration of different types of evolutionary models in an attempt to determine which of them lead to power law distributions has the potential of revealing non-trivial aspects of genome evolution. Results A simple model of evolution of the domain composition of proteomes was developed, with the following elementary processes: i domain birth (duplication with divergence, ii death (inactivation and/or deletion, and iii innovation (emergence from non-coding or non-globular sequences or acquisition via horizontal gene transfer. This formalism can be described as a birth, death and innovation model (BDIM. The formulas for equilibrium frequencies of domain families of different size and the total number of families at equilibrium are derived for a general BDIM. All asymptotics of equilibrium frequencies of domain families possible for the given type of models are found and their appearance depending on model parameters is investigated. It is proved that the power law asymptotics appears if, and only if, the model is balanced, i.e. domain duplication and deletion rates are asymptotically equal up to the second order. It is further proved that any power asymptotic with the degree not equal to -1 can appear only if the hypothesis of independence of the duplication/deletion rates on the size of a domain family is rejected. Specific cases of BDIMs, namely simple, linear, polynomial and rational

  9. Model cell membranes

    DEFF Research Database (Denmark)

    Günther-Pomorski, Thomas; Nylander, Tommy; Cardenas Gomez, Marite

    2014-01-01

    The high complexity of biological membranes has motivated the development and application of a wide range of model membrane systems to study biochemical and biophysical aspects of membranes in situ under well defined conditions. The aim is to provide fundamental understanding of processes control...

  10. A simple structure of Cu2ZnSnS4/CdS solar cells prepared by sputtering

    Science.gov (United States)

    Li, Zhishan; Wang, Shurong; Ma, Xun; Yang, Min; Jiang, Zhi; Liu, Tao; Lu, Yilei; Liu, Sijia

    2017-12-01

    In this work, Cu2ZnSnS4 (CZTS) thin films were grown on Mo-coated Soda-lime-glass (SLG) substrates by annealing of sputtered ZnS/Sn/CuS precursors at 580 ℃ for 15 min. As a try, the CZTS solar cells were fabricated using simple structure of Mo-coated SLG/CZTS/CdS/Al and traditional structure of Mo-coated SLG/CZTS/CdS/i-ZnO/In2O3:SnO2 (ITO)/Al, respectively. The results show that the CZTS device with simple structure can achieve same level of the open circuit voltage (Voc) compared with that of traditional structure. In addition, the power conversion efficiency of 2.95% and 3.59% were obtained with simple structure and traditional structure, respectively. The CZTS solar cell with simple structure provides a promising way and an easy process to prepare high-performance CZTS thin film solar cells which is available to large-scale industrial production in the future.

  11. Computing a single cell in the overlay of two simple polygons

    NARCIS (Netherlands)

    Berg, M. de; Devillers, O.; Dobrindt, K.T.G.; Schwarzkopf, O.

    1997-01-01

    This note combines the lazy randomized incremental construction scheme with the technique of \\connectivity acceleration" to obtain an O ( n (log ? n ) 2 ) time randomized algorithm to compute a single face in the overlay oftwo simple polygons in the plane.

  12. Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticles with polyethylenimine coat as simple, safe, and versatile vehicles for cell targeting: population characteristics, cell uptake, and intracellular trafficking.

    Science.gov (United States)

    Wu, Lin-Ping; Wang, Danyang; Parhamifar, Ladan; Hall, Arnaldur; Chen, Guo-Qiang; Moghimi, Seyed M

    2014-06-01

    A simple and highly safe poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticulate delivery system that targets different cell types is developed. A sub-cytotoxic level of polyethylenimine coat mediates universal cell targeting. Internalized nanoparticles traffic along endolysosomal compartments, endoplasmic reticulum and the Golgi complex. Nanoparticles have no detrimental effects on cell morphology and respiration. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Using simple agent-based modeling to inform and enhance neighborhood walkability

    Science.gov (United States)

    2013-01-01

    Background Pedestrian-friendly neighborhoods with proximal destinations and services encourage walking and decrease car dependence, thereby contributing to more active and healthier communities. Proximity to key destinations and services is an important aspect of the urban design decision making process, particularly in areas adopting a transit-oriented development (TOD) approach to urban planning, whereby densification occurs within walking distance of transit nodes. Modeling destination access within neighborhoods has been limited to circular catchment buffers or more sophisticated network-buffers generated using geoprocessing routines within geographical information systems (GIS). Both circular and network-buffer catchment methods are problematic. Circular catchment models do not account for street networks, thus do not allow exploratory ‘what-if’ scenario modeling; and network-buffering functionality typically exists within proprietary GIS software, which can be costly and requires a high level of expertise to operate. Methods This study sought to overcome these limitations by developing an open-source simple agent-based walkable catchment tool that can be used by researchers, urban designers, planners, and policy makers to test scenarios for improving neighborhood walkable catchments. A simplified version of an agent-based model was ported to a vector-based open source GIS web tool using data derived from the Australian Urban Research Infrastructure Network (AURIN). The tool was developed and tested with end-user stakeholder working group input. Results The resulting model has proven to be effective and flexible, allowing stakeholders to assess and optimize the walkability of neighborhood catchments around actual or potential nodes of interest (e.g., schools, public transport stops). Users can derive a range of metrics to compare different scenarios modeled. These include: catchment area versus circular buffer ratios; mean number of streets crossed; and

  14. Mid-range atmospheric dispersion modelling. Intercomparison of simple models in EMRAS-2 project.

    Science.gov (United States)

    Periáñez, Raúl; Thiessen, Kathleen M; Chouhan, Sohan L; Mancini, Francesco; Navarro, Emilie; Sdouz, Gert; Trifunović, Dejan

    2016-10-01

    An intercomparison of atmospheric dispersion models has been carried out for a hypothetical accident occurring in a nuclear power plant in the center of Spain. The accident consisted of a steam generator tube rupture, and two radionuclides have been considered for the exercise: 137-Cs and 131-I. Meteorological conditions and radionuclide release rates were supplied. Models provided deposition maps, timeintegrated concentrations in air and arrival times of the plumes to specific locations. The effect of the meteorological conditions used in the modelling was clear, with different behavior of the plume with neutral stability vs. stable conditions. The predicted arrival times of the plume at specific locations showed much less variability than deposition and air concentrations. This variability in part reflects the uncertainties inherent in atmospheric dispersion modelling and in the selection of parameter values, such as deposition velocities or diffusivities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Physical models of cell motility

    CERN Document Server

    2016-01-01

    This book surveys the most recent advances in physics-inspired cell movement models. This synergetic, cross-disciplinary effort to increase the fidelity of computational algorithms will lead to a better understanding of the complex biomechanics of cell movement, and stimulate progress in research on related active matter systems, from suspensions of bacteria and synthetic swimmers to cell tissues and cytoskeleton.Cell motility and collective motion are among the most important themes in biology and statistical physics of out-of-equilibrium systems, and crucial for morphogenesis, wound healing, and immune response in eukaryotic organisms. It is also relevant for the development of effective treatment strategies for diseases such as cancer, and for the design of bioactive surfaces for cell sorting and manipulation. Substrate-based cell motility is, however, a very complex process as regulatory pathways and physical force generation mechanisms are intertwined. To understand the interplay between adhesion, force ...

  16. Modelling radiation fluxes in simple and complex environments--application of the RayMan model.

    Science.gov (United States)

    Matzarakis, Andreas; Rutz, Frank; Mayer, Helmut

    2007-03-01

    The most important meteorological parameter affecting the human energy balance during sunny weather conditions is the mean radiant temperature T(mrt). It considers the uniform temperature of a surrounding surface giving off blackbody radiation, which results in the same energy gain of a human body given the prevailing radiation fluxes. This energy gain usually varies considerably in open space conditions. In this paper, the model 'RayMan', used for the calculation of short- and long-wave radiation fluxes on the human body, is presented. The model, which takes complex urban structures into account, is suitable for several applications in urban areas such as urban planning and street design. The final output of the model is, however, the calculated T(mrt), which is required in the human energy balance model, and thus also for the assessment of the urban bioclimate, with the use of thermal indices such as predicted mean vote (PMV), physiologically equivalent temperature (PET) and standard effective temperature (SET*). The model has been developed based on the German VDI-Guidelines 3789, Part II (environmental meteorology, interactions between atmosphere and surfaces; calculation of short- and long-wave radiation) and VDI-3787 (environmental meteorology, methods for the human-biometeorological evaluation of climate and air quality for urban and regional planning. Part I: climate). The validation of the results of the RayMan model agrees with similar results obtained from experimental studies.

  17. Co-digestion of solid waste: Towards a simple model to predict methane production.

    Science.gov (United States)

    Kouas, Mokhles; Torrijos, Michel; Schmitz, Sabine; Sousbie, Philippe; Sayadi, Sami; Harmand, Jérôme

    2018-04-01

    Modeling methane production is a key issue for solid waste co-digestion. Here, the effect of a step-wise increase in the organic loading rate (OLR) on reactor performance was investigated, and four new models were evaluated to predict methane yields using data acquired in batch mode. Four co-digestion experiments of mixtures of 2 solid substrates were conducted in semi-continuous mode. Experimental methane yields were always higher than the BMP values of mixtures calculated from the BMP of each substrate, highlighting the importance of endogenous production (methane produced from auto-degradation of microbial community and generated solids). The experimental methane productions under increasing OLRs corresponded well to the modeled data using the model with constant endogenous production and kinetics identified at 80% from total batch time. This model provides a simple and useful tool for technical design consultancies and plant operators to optimize the co-digestion and the choice of the OLRs. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. Practical and Simple Wireless Channel Models for Use in Multipolarized Antenna Systems

    Directory of Open Access Journals (Sweden)

    KwangHyun Jeon

    2014-01-01

    Full Text Available The next-generation wireless systems are expected to support data rates of more than 100 Mbps in outdoor environments. In order to support such large payloads, a polarized antenna may be employed as one of the candidate technologies. Recently, the third generation partnership standards bodies (3GPP/3GPP2 have defined a cross-polarized channel model in SCM-E for MIMO systems; however, this model is quite complex since it considers a great many channel-related parameters. Furthermore, the SCM-E channel model combines the channel coefficients of all the polarization links into one complex output, making it impossible to exploit the MIMO spatial multiplexing or diversity gains in the case of employing polarized antenna at transmitter and receiver side. In this paper, we present practical and simple 2D and 3D multipolarized multipath channel models, which take into account both the cross-polarization discrimination (XPD and the Rician factor. After verifying the proposed channel models, the BER and PER performances and throughput using the EGC and MRC combining techniques are evaluated in multipolarized antenna systems.

  19. A simple model of HIV epidemic in Italy: The role of the antiretroviral treatment.

    Science.gov (United States)

    Papa, Federico; Binda, Francesca; Felici, Giovanni; Franzetti, Marco; Gandolfi, Alberto; Sinisgalli, Carmela; Balotta, Claudia

    2018-02-01

    In the present paper we propose a simple time-varying ODE model to describe the evolution of HIV epidemic in Italy. The model considers a single population of susceptibles, without distinction of high-risk groups within the general population, and accounts for the presence of immigration and emigration, modelling their effects on both the general demography and the dynamics of the infected subpopulations. To represent the intra-host disease progression, the untreated infected population is distributed over four compartments in cascade according to the CD4 counts. A further compartment is added to represent infected people under antiretroviral therapy. The per capita exit rate from treatment, due to voluntary interruption or failure of therapy, is assumed variable with time. The values of the model parameters not reported in the literature are assessed by fitting available epidemiological data over the decade 2003÷2012. Predictions until year 2025 are computed, enlightening the impact on the public health of the early initiation of the antiretroviral therapy. The benefits of this change in the treatment eligibility consist in reducing the HIV incidence rate, the rate of new AIDS cases, and the rate of death from AIDS. Analytical results about properties of the model in its time-invariant form are provided, in particular the global stability of the equilibrium points is established either in the absence and in the presence of infected among immigrants.

  20. A Simple Model for the Evolution of Multi-Stranded Coronal Loops

    Science.gov (United States)

    Fuentes, M. C. Lopez; Klimchuk, J. A.

    2010-01-01

    We develop and analyze a simple cellular automaton (CA) model that reproduces the main properties of the evolution of soft X-ray coronal loops. We are motivated by the observation that these loops evolve in three distinguishable phases that suggest the development, maintainance, and decay of a self-organized system. The model is based on the idea that loops are made of elemental strands that are heated by the relaxation of magnetic stress in the form of nanoflares. In this vision, usually called "the Parker conjecture" (Parker 1988), the origin of stress is the displacement of the strand footpoints due to photospheric convective motions. Modeling the response and evolution of the plasma we obtain synthetic light curves that have the same characteristic properties (intensity, fluctuations, and timescales) as the observed cases. We study the dependence of these properties on the model parameters and find scaling laws that can be used as observational predictions of the model. We discuss the implications of our results for the interpretation of recent loop observations in different wavelengths. Subject headings: Sun: corona - Sun: flares - Sun: magnetic topology - Sun: X-rays, gamma rays

  1. A simple model of the effect of ocean ventilation on ocean heat uptake

    Science.gov (United States)

    Nadiga, Balu; Urban, Nathan

    2017-11-01

    Transport of water from the surface mixed layer into the ocean interior is achieved, in large part, by the process of ventilation-a process associated with outcropping isopycnals. Starting from such a configuration of outcropping isopycnals, we derive a simple model of the effect of ventilation on ocean uptake of anomalous radiative forcing. This model can be seen as an improvement of the popular anomaly-diffusing class of energy balance models (AD-EBM) that are routinely employed to analyze and emulate the warming response of both observed and simulated Earth system. We demonstrate that neither multi-layer, nor continuous-diffusion AD-EBM variants can properly represent both surface-warming and the vertical distribution of ocean heat uptake. The new model overcomes this deficiency. The simplicity of the models notwithstanding, the analysis presented and the necessity of the modification is indicative of the role played by processes related to the down-welling branch of global ocean circulation in shaping the vertical distribution of ocean heat uptake.

  2. A simple and complete model for wind turbine wakes over complex terrain

    Science.gov (United States)

    Rommelfanger, Nick; Rajborirug, Mai; Luzzatto-Fegiz, Paolo

    2017-11-01

    Simple models for turbine wakes have been used extensively in the wind energy community, both as independent tools, as well as to complement more refined and computationally-intensive techniques. These models typically prescribe empirical relations for how the wake radius grows with downstream distance x and obtain the wake velocity at each x through the application of either mass conservation, or of both mass and momentum conservation (e.g. Katić et al. 1986; Frandsen et al. 2006; Bastankhah & Porté-Agel 2014). Since these models assume a global behavior of the wake (for example, linear spreading with x) they cannot respond to local changes in background flow, as may occur over complex terrain. Instead of assuming a global wake shape, we develop a model by relying on a local assumption for the growth of the turbulent interface. To this end, we introduce to wind turbine wakes the use of the entrainment hypothesis, which has been used extensively in other areas of geophysical fluid dynamics. We obtain two coupled ordinary differential equations for mass and momentum conservation, which can be readily solved with a prescribed background pressure gradient. Our model is in good agreement with published data for the development of wakes over complex terrain.

  3. A simple parameterization of sub-grid scale open water for climate models

    Science.gov (United States)

    Pitman, Aj

    1991-09-01

    The effects of small fractions ( water covering a grid element are currently neglected even in atmospheric general circulation models (AGCMs) which incorporate complex land surface parameterization schemes. Here, a method for simulating sub-grid scale open water is proposed which permits any existing land surface model to be modified to account for open water. This new parameterization is tested as an addition to an advanced land surface scheme and, as expected, is shown to produce general increases in the surface latent heat flux at the expense of the surface sensible heat flux. Small changes in temperature are associated with this change in the partitioning of available energy which is driven by an increase in the wetness of the grid element. The sensitivity of the land surface to increasing amounts of open water is dependent upon the type of vegetation represented. Dense vegetation (with a high leaf area index) is shown to complicate the apparently simple model sensitivity and indicates that more advanced methods of incorporating open water into AGCMs need to be considered and compared against the parameterization suggested here. However, the sensitivity of one land surface model to incorporating open water is large enough to warrant consideration of its incorporation into climate models.

  4. Simple canine model of arterial thrombosis with endothelial injury suitable for investigation of thrombolytic agents

    International Nuclear Information System (INIS)

    Badylak, S.F.; Poehlman, E.; Williams, C.; Klabunde, R.E.; Turek, J.; Schoenlein, W.

    1988-01-01

    Three separate studies were done to evaluate a new canine model of arterial thrombosis with endothelial injury. Endothelial injury was produced by exposing the luminal surface of a 2-cm segment of femoral artery to 100 degrees C saline for 5 min. There was no disruption of proximal or distal blood flow with this model, and thrombolysis was continuously monitored by measuring 125 I-labelled fibrin gamma emissions from the thrombus. Study No. 1 showed that complete endothelial denudation was achieved with this model. Study No. 2 demonstrated 1) adherence of the experimentally induced thrombus to subendothelial connective tissue, and 2) endogenous thrombolysis of approximately 9% during the initial 2 h after thrombus formation. Study No. 3 tested the usefulness of the model for evaluating the thrombolytic efficacy of urokinase. Urokinase (30,000 U/Kg, bolus IV injection) caused 38 +/- 5.4% thrombolysis within 90 min of drug administration versus 5.9 +/- 2.4% for a saline-treated control group. We conclude that this model provides a technically simple and reproducible method for the laboratory investigation of thrombosis and thrombolysis in arteries with endothelial injury

  5. On the thermoluminescent interactive multiple-trap system (IMTS) model: is it a simple model?

    International Nuclear Information System (INIS)

    Gil T, M. I.; Perez C, L.; Cruz Z, E.; Furetta, C.; Roman L, J.

    2016-10-01

    In the thermally stimulated luminescence phenomenon, named thermoluminescence (Tl), the electrons and holes generated by the radiation-matter interaction can be trapped by the metastable levels in the band gap of the solid. Following, the electron can be thermally releases into the conduction band and a radiatively recombination with hole close to the recombination center occurred and the glow curve is emitted. However, the complex mechanism of trapping and thermally releases occurred in the band gap of solid. Some models, such as; first, second and general-order kinetics, have been well established to explain the behaviour of the glow curves and their defects recombination mechanism. In this work, expressions for and Interactive Multiple-Trap System model (IMTS) was obtained assuming: a set of discrete electron traps (active traps At), another set of thermally disconnected trap (TDT) and a recombination center (Rc) too. A numerical analysis based on the Levenberg-Marquardt method in conjunction with an implicit Rosenbrock method was taken into account to simulate the glow curve. The numerical method was tested through synthetic Tl glow curves for a wide range of trap parameters. The activation energy and kinetics order were determined using values from the General Order Kinetics (GOK) model as entry data to IMTS model. This model was tested using the experimental glow curves obtained from Ce or Eu-doped MgF 2 (LiF) polycrystals samples. Results shown that the IMTS model can predict more accurately the behavior of the Tl glow curves that those obtained by the GOK modified by Rasheedy and by the Mixed Order Kinetics model. (Author)

  6. On the thermoluminescent interactive multiple-trap system (IMTS) model: is it a simple model?

    Energy Technology Data Exchange (ETDEWEB)

    Gil T, M. I.; Perez C, L. [UNAM, Facultad de Quimica, Ciudad Universitaria, 04510 Ciudad de Mexico (Mexico); Cruz Z, E.; Furetta, C.; Roman L, J., E-mail: ecruz@nucleares.unam.mx [UNAM, Instituto de Ciencias Nucleares, Ciudad Universitaria, 04510 Ciudad de Mexico (Mexico)

    2016-10-15

    In the thermally stimulated luminescence phenomenon, named thermoluminescence (Tl), the electrons and holes generated by the radiation-matter interaction can be trapped by the metastable levels in the band gap of the solid. Following, the electron can be thermally releases into the conduction band and a radiatively recombination with hole close to the recombination center occurred and the glow curve is emitted. However, the complex mechanism of trapping and thermally releases occurred in the band gap of solid. Some models, such as; first, second and general-order kinetics, have been well established to explain the behaviour of the glow curves and their defects recombination mechanism. In this work, expressions for and Interactive Multiple-Trap System model (IMTS) was obtained assuming: a set of discrete electron traps (active traps At), another set of thermally disconnected trap (TDT) and a recombination center (Rc) too. A numerical analysis based on the Levenberg-Marquardt method in conjunction with an implicit Rosenbrock method was taken into account to simulate the glow curve. The numerical method was tested through synthetic Tl glow curves for a wide range of trap parameters. The activation energy and kinetics order were determined using values from the General Order Kinetics (GOK) model as entry data to IMTS model. This model was tested using the experimental glow curves obtained from Ce or Eu-doped MgF{sub 2}(LiF) polycrystals samples. Results shown that the IMTS model can predict more accurately the behavior of the Tl glow curves that those obtained by the GOK modified by Rasheedy and by the Mixed Order Kinetics model. (Author)

  7. Simple, Validated Vaginal Birth After Cesarean Delivery Prediction Model for Use at the Time of Admission

    Science.gov (United States)

    Metz, Torri D.; Stoddard, Gregory J.; Henry, Erick; Jackson, Marc; Holmgren, Calla; Esplin, Sean

    2017-01-01

    OBJECTIVE To create a simple tool for predicting the likelihood of successful trial of labor after cesarean delivery (TOLAC) during the pregnancy after a primary cesarean delivery using variables available at the time of admission. METHODS Data for all deliveries at 14 regional hospitals over an 8-year period were reviewed. Women with one cesarean delivery and one subsequent delivery were included. Variables associated with successful VBAC were identified using multivariable logistic regression. Points were assigned to these characteristics, with weighting based on the coefficients in the regression model to calculate an integer VBAC score. The VBAC score was correlated with TOLAC success rate and was externally validated in an independent cohort using a logistic regression model. RESULTS A total of 5,445 women met inclusion criteria. Of those women, 1,170 (21.5%) underwent TOLAC. Of the women who underwent trial of labor, 938 (80%) had a successful VBAC. AVBAC score was generated based on the Bishop score (cervical examination) at the time of admission, with points added for history of vaginal birth, age younger than 35 years, absence of recurrent indication, and body mass index less than 30. Women with a VBAC score less than 10 had a likelihood of TOLAC success less than 50%. Women with a VBAC score more than 16 had a TOLAC success rate more than 85%. The model performed well in an independent cohort with an area under the curve of 0.80 (95% confidence interval 0.76–0.84). CONCLUSIONS Prediction of TOLAC success at the time of admission is highly dependent on the initial cervical examination. This simple VBAC score can be utilized when counseling women considering TOLAC. PMID:23921867

  8. Scenario Analysis With Economic-Energy Systems Models Coupled to Simple Climate Models

    Science.gov (United States)

    Hanson, D. A.; Kotamarthi, V. R.; Foster, I. T.; Franklin, M.; Zhu, E.; Patel, D. M.

    2008-12-01

    Here, we compare two scenarios based on Stanford University's Energy Modeling Forum Study 22 on global cooperative and non-cooperative climate policies. In the former, efficient transition paths are implemented including technology Research and Development effort, energy conservation programs, and price signals for greenhouse gas (GHG) emissions. In the non-cooperative case, some countries try to relax their regulations and be free riders. Total emissions and costs are higher in the non-cooperative scenario. The simulations, including climate impacts, run to the year 2100. We use the Argonne AMIGA-MARS economic-energy systems model, the Texas AM University's Forest and Agricultural Sector Optimization Model (FASOM), and the University of Illinois's Integrated Science Assessment Model (ISAM), with offline coupling between the FASOM and AMIGA-MARS and an online coupling between AMIGA-MARS and ISAM. This set of models captures the interaction of terrestrial systems, land use, crops and forests, climate change, human activity, and energy systems. Our scenario simulations represent dynamic paths over which all the climate, terrestrial, economic, and energy technology equations are solved simultaneously Special attention is paid to biofuels and how they interact with conventional gasoline/diesel fuel markets. Possible low-carbon penetration paths are based on estimated costs for new technologies, including cellulosic biomass, coal-to-liquids, plug-in electric vehicles, solar and nuclear energy. We explicitly explore key uncertainties that affect mitigation and adaptation scenarios.

  9. A Simple and Accurate Model to Predict Responses to Multi-electrode Stimulation in the Retina.

    Science.gov (United States)

    Maturana, Matias I; Apollo, Nicholas V; Hadjinicolaou, Alex E; Garrett, David J; Cloherty, Shaun L; Kameneva, Tatiana; Grayden, David B; Ibbotson, Michael R; Meffin, Hamish

    2016-04-01

    Implantable electrode arrays are widely used in therapeutic stimulation of the nervous system (e.g. cochlear, retinal, and cortical implants). Currently, most neural prostheses use serial stimulation (i.e. one electrode at a time) despite this severely limiting the repertoire of stimuli that can be applied. Methods to reliably predict the outcome of multi-electrode stimulation have not been available. Here, we demonstrate that a linear-nonlinear model accurately predicts neural responses to arbitrary patterns of stimulation using in vitro recordings from single retinal ganglion cells (RGCs) stimulated with a subretinal multi-electrode array. In the model, the stimulus is projected onto a low-dimensional subspace and then undergoes a nonlinear transformation to produce an estimate of spiking probability. The low-dimensional subspace is estimated using principal components analysis, which gives the neuron's electrical receptive field (ERF), i.e. the electrodes to which the neuron is most sensitive. Our model suggests that stimulation proportional to the ERF yields a higher efficacy given a fixed amount of power when compared to equal amplitude stimulation on up to three electrodes. We find that the model captures the responses of all the cells recorded in the study, suggesting that it will generalize to most cell types in the retina. The model is computationally efficient to evaluate and, therefore, appropriate for future real-time applications including stimulation strategies that make use of recorded neural activity to improve the stimulation strategy.

  10. A Simple and Accurate Model to Predict Responses to Multi-electrode Stimulation in the Retina.

    Directory of Open Access Journals (Sweden)

    Matias I Maturana

    2016-04-01

    Full Text Available Implantable electrode arrays are widely used in therapeutic stimulation of the nervous system (e.g. cochlear, retinal, and cortical implants. Currently, most neural prostheses use serial stimulation (i.e. one electrode at a time despite this severely limiting the repertoire of stimuli that can be applied. Methods to reliably predict the outcome of multi-electrode stimulation have not been available. Here, we demonstrate that a linear-nonlinear model accurately predicts neural responses to arbitrary patterns of stimulation using in vitro recordings from single retinal ganglion cells (RGCs stimulated with a subretinal multi-electrode array. In the model, the stimulus is projected onto a low-dimensional subspace and then undergoes a nonlinear transformation to produce an estimate of spiking probability. The low-dimensional subspace is estimated using principal components analysis, which gives the neuron's electrical receptive field (ERF, i.e. the electrodes to which the neuron is most sensitive. Our model suggests that stimulation proportional to the ERF yields a higher efficacy given a fixed amount of power when compared to equal amplitude stimulation on up to three electrodes. We find that the model captures the responses of all the cells recorded in the study, suggesting that it will generalize to most cell types in the retina. The model is computationally efficient to evaluate and, therefore, appropriate for future real-time applications including stimulation strategies that make use of recorded neural activity to improve the stimulation strategy.

  11. Simple physics-based models of compensatory plant water uptake: concepts and eco-hydrological consequences

    Directory of Open Access Journals (Sweden)

    N. J. Jarvis

    2011-11-01

    Full Text Available Many land surface schemes and simulation models of plant growth designed for practical use employ simple empirical sub-models of root water uptake that cannot adequately reflect the critical role water uptake from sparsely rooted deep subsoil plays in meeting atmospheric transpiration demand in water-limited environments, especially in the presence of shallow groundwater. A failure to account for this so-called "compensatory" water uptake may have serious consequences for both local and global modeling of water and energy fluxes, carbon balances and climate. Some purely empirical compensatory root water uptake models have been proposed, but they are of limited use in global modeling exercises since their parameters cannot be related to measurable soil and vegetation properties. A parsimonious physics-based model of uptake compensation has been developed that requires no more parameters than empirical approaches. This model is described and some aspects of its behavior are illustrated with the help of example simulations. These analyses demonstrate that hydraulic lift can be considered as an extreme form of compensation and that the degree of compensation is principally a function of soil capillarity and the ratio of total effective root length to potential transpiration. Thus, uptake compensation increases as root to leaf area ratios increase, since potential transpiration depends on leaf area. Results of "scenario" simulations for two case studies, one at the local scale (riparian vegetation growing above shallow water tables in seasonally dry or arid climates and one at a global scale (water balances across an aridity gradient in the continental USA, are presented to illustrate biases in model predictions that arise when water uptake compensation is neglected. In the first case, it is shown that only a compensated model can match the strong relationships between water table depth and leaf area and transpiration observed in riparian forest

  12. Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the "inside and outside" pattern of cell sorting

    Directory of Open Access Journals (Sweden)

    Ajioka Itsuki

    2007-09-01

    Full Text Available Abstract Background Development of multicellular organisms proceeds from a single fertilized egg as the combined effect of countless numbers of cellular interactions among highly dynamic cells. Since at least a reminiscent pattern of morphogenesis can be recapitulated in a reproducible manner in reaggregation cultures of dissociated embryonic cells, which is known as cell sorting, the cells themselves must possess some autonomous cell behaviors that assure specific and reproducible self-organization. Understanding of this self-organized dynamics of heterogeneous cell population seems to require some novel approaches so that the approaches bridge a gap between molecular events and morphogenesis in developmental and cell biology. A conceptual cell model in a computer may answer that purpose. We constructed a dynamical cell model based on autonomous cell behaviors, including cell shape, growth, division, adhesion, transformation, and motility as well as cell-cell signaling. The model gives some insights about what cellular behaviors make an appropriate global pattern of the cell population. Results We applied the model to "inside and outside" pattern of cell-sorting, in which two different embryonic cell types within a randomly mixed aggregate are sorted so that one cell type tends to gather in the central region of the aggregate and the other cell type surrounds the first cell type. Our model can modify the above cell behaviors by varying parameters related to them. We explored various parameter sets with which the "inside and outside" pattern could be achieved. The simulation results suggested that direction of cell movement responding to its neighborhood and the cell's mobility are important for this specific rearrangement. Conclusion We constructed an in silico cell model that mimics autonomous cell behaviors and applied it to cell sorting, which is a simple and appropriate phenomenon exhibiting self-organization of cell population. The model

  13. Simple enzymatic procedure for l‐carnosine synthesis: whole‐cell biocatalysis and efficient biocatalyst recycling

    Science.gov (United States)

    Heyland, Jan; Antweiler, Nicolai; Lutz, Jochen; Heck, Tobias; Geueke, Birgit; Kohler, Hans‐Peter E.; Blank, Lars M.; Schmid, Andreas

    2010-01-01

    Summary β‐Peptides and their derivates are usually stable to proteolysis and have an increased half‐life compared with α‐peptides. Recently, β‐aminopeptidases were described as a new enzyme class that enabled the enzymatic degradation and formation of β‐peptides. As an alternative to the existing chemical synthesis routes, the aim of the present work was to develop a whole‐cell biocatalyst for the synthesis and production of β‐peptides using this enzymatic activity. For the optimization of the reaction system we chose the commercially relevant β,α‐dipeptide l‐carnosine (β‐alanine‐l‐histidine) as model product. We were able to show that different recombinant yeast and bacteria strains, which overexpress a β‐peptidase, could be used directly as whole‐cell biocatalysts for the synthesis of l‐carnosine. By optimizing relevant reaction conditions for the best‐performing recombinant Escherichia coli strain, such as pH and substrate concentrations, we obtained high l‐carnosine yields of up to 71%. Long‐time as well as biocatalyst recycling experiments indicated a high stability of the developed biocatalyst for at least five repeated batches. Application of the recombinant E. coli in a fed‐batch process enabled the accumulation of l‐carnosine to a concentration of 3.7 g l−1. PMID:21255308

  14. Modeling Behavior in Different Delay Match to Sample Tasksin One Simple Network

    Directory of Open Access Journals (Sweden)

    Yali eAmit

    2013-07-01

    Full Text Available Delay match to sample (DMS experiments provide an important link between the theory of recurrent network models and behavior and neural recordings. We define a simple recurrent network of binary neurons with stochastic neural dynamics and Hebbian synaptic learning. Most DMS experiments involve heavily learned images, and in this setting we propose a readout mechanism for match occurrence based on a smaller increment in overall network activity when the matched pattern is already in working memory, and a reset mechanism to clear memory from stimuli of previous trials using random network activity. Simulations show that this model accounts for a wide range of variations on the original DMS tasks, including ABBA tasks with distractors, and more general repetition detection tasks with both learned and novel images. The differences in network settings required for different tasks derive from easily defined changes in the levels of noise and inhibition. The same models can also explain experiments involving repetition detection with novel images, although in this case the readout mechanism for match is based on higher overall network activity. The models give rise to interesting predictions that may be tested in neural recordings.

  15. Multi-agent modeling for the simulation of a simple smart microgrid

    International Nuclear Information System (INIS)

    Kremers, Enrique; Gonzalez de Durana, Jose; Barambones, Oscar

    2013-01-01

    Highlights: • We created a systemic modular model for a microgrid with a load flow calculation. • The model is modular and besides the power devices includes also a communication layer. • An agent-based approach allows to include intelligent strategies on every node of the system. • First feasibility simulations were run to show the possible outcomes of generator and load management strategies. - Abstract: The smart grid is a highly complex system that is being formed from the traditional power grid, adding new and sophisticated communication and control devices. This will enable integrating new elements for distributed power generation and also achieving an increasingly automated operation so for actions of the utilities as for customers. In order to model such systems, a bottom-up method is followed, using only a few basic elements which are structured into two layers: a physical layer for the electrical power transmission and one logical layer for element communication. A simple case study is presented to analyze the possibilities of simulation. It shows a microgrid model with dynamic load management and an integrated approach that can process both electrical and communication flows

  16. A simple estimation model of aerosol optical thickness based on meteorological station observed atmospheric visibility

    Science.gov (United States)

    Li, Zhu; Chen, Jianyu; Gong, Shaoqi; Mao, Zhihua; Hao, Zengzhou

    2013-09-01

    Aerosol optical thickness (AOT) and atmospheric visibility are two important weather parameters. AOT reflects the state of the atmosphere,-and atmospheric visibility is widely used in various aspects of social life. Generally, it is reported in literatures that both of them are affected by Air Pollutants and other meteorological factors, such as surface pressure, ground temperature, wind speed, precipitation. In this paper, a statistic relationship expression is established between AOT and atmospheric visibility on the basis of the point-to-point meteorological observations. In the national region, the correlation between atmospheric visibility and weather factors indicates that the surface pressure has great influence on atmospheric visibility all the year round. And the influence based on precipitation is more obvious in spring and summer, mean-while wind speed and temperature play important roles in autumn and winter. A significant positive correlation was found between AOT and API. To express the relationship between atmospheric visibility and AOT, some computable models were utilized. According to the accuracy analysis, the cubic curve model and the power function model are more accurate. And both RMSE (root-mean-square error) of them is higher than 0.47. But the coefficient of cubic curve is more complex in practice. Finally, a simple estimation model of aerosol optical thickness based on meteorological station observed atmospheric visibility was conducted using power function. The Pearson coefficient between calculation of power function and observation is 0.73.

  17. Electrostatics of cysteine residues in proteins: Parameterization and validation of a simple model

    Science.gov (United States)

    Salsbury, Freddie R.; Poole, Leslie B.; Fetrow, Jacquelyn S.

    2013-01-01

    One of the most popular and simple models for the calculation of pKas from a protein structure is the semi-macroscopic electrostatic model MEAD. This model requires empirical parameters for each residue to calculate pKas. Analysis of current, widely used empirical parameters for cysteine residues showed that they did not reproduce expected cysteine pKas; thus, we set out to identify parameters consistent with the CHARMM27 force field that capture both the behavior of typical cysteines in proteins and the behavior of cysteines which have perturbed pKas. The new parameters were validated in three ways: (1) calculation across a large set of typical cysteines in proteins (where the calculations are expected to reproduce expected ensemble behavior); (2) calculation across a set of perturbed cysteines in proteins (where the calculations are expected to reproduce the shifted ensemble behavior); and (3) comparison to experimentally determined pKa values (where the calculation should reproduce the pKa within experimental error). Both the general behavior of cysteines in proteins and the perturbed pKa in some proteins can be predicted reasonably well using the newly determined empirical parameters within the MEAD model for protein electrostatics. This study provides the first general analysis of the electrostatics of cysteines in proteins, with specific attention paid to capturing both the behavior of typical cysteines in a protein and the behavior of cysteines whose pKa should be shifted, and validation of force field parameters for cysteine residues. PMID:22777874

  18. Symmetrization of excess Gibbs free energy: A simple model for binary liquid mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Castellanos-Suarez, Aly J., E-mail: acastell@ivic.gob.v [Centro de Estudios Interdisciplinarios de la Fisica (CEIF), Instituto Venezolano de Investigaciones Cientificas (IVIC), Apartado 21827, Caracas 1020A (Venezuela, Bolivarian Republic of); Garcia-Sucre, Maximo, E-mail: mgs@ivic.gob.v [Centro de Estudios Interdisciplinarios de la Fisica (CEIF), Instituto Venezolano de Investigaciones Cientificas (IVIC), Apartado 21827, Caracas 1020A (Venezuela, Bolivarian Republic of)

    2011-03-15

    A symmetric expression for the excess Gibbs free energy of liquid binary mixtures is obtained using an appropriate definition for the effective contact fraction. We have identified a mechanism of local segregation as the main cause of the contact fraction variation with the concentration. Starting from this mechanism we develop a simple model for describing binary liquid mixtures. In this model two parameters appear: one adjustable, and the other parameter depending on the first one. Following this procedure we reproduce the experimental data of (liquid + vapor) equilibrium with a degree of accuracy comparable to well-known more elaborated models. The way in which we take into account the effective contacts between molecules allows identifying the compound which may be considered to induce one of the following processes: segregation, anti-segregation and dispersion of the components in the liquid mixture. Finally, the simplicity of the model allows one to obtain only one resulting interaction energy parameter, which makes easier the physical interpretation of the results.

  19. A Lagrange-based generalised formulation for the equations of motion of simple walking models.

    Science.gov (United States)

    McGrath, Michael; Howard, David; Baker, Richard

    2017-04-11

    Simple 2D models of walking often approximate the human body to multi-link dynamic systems, where body segments are represented by rigid links connected by frictionless hinge joints. Performing forward dynamics on the equations of motion (EOM) of these systems can be used to simulate their movement. However, deriving these equations can be time consuming. Using Lagrangian mechanics, a generalised formulation for the EOM of n-link open-loop chains is derived. This can be used for single support walking models. This has an advantage over Newton-Euler mechanics in that it is independent of coordinate system and prior knowledge of the ground reaction force (GRF) is not required. Alternative strategies, such as optimisation algorithms, can be used to estimate joint activation and simulate motion. The application of Lagrange multipliers, to enforce motion constraints, is used to adapt this general formulation for application to closed-loop chains. This can be used for double support walking models. Finally, inverse dynamics are used to calculate the GRF for these general n-link chains. The necessary constraint forces to maintain a closed-loop chain, calculated from the Lagrange multipliers, are one solution to the indeterminate problem of GRF distribution in double support models. An example of this method's application is given, whereby an optimiser estimates the joint moments by tracking kinematic data. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. On forced oscillations of a simple model for a novel wave energy converter

    KAUST Repository

    Orazov, Bayram

    2011-05-11

    The dynamics of a simple model for an ocean wave energy converter is discussed. The model for the converter is a hybrid system consisting of a pair of harmonically excited mass-spring-dashpot systems and a set of four state-dependent switching rules. Of particular interest is the response of the model to a wide spectrum of harmonic excitations. Partially because of the piecewise-smooth dynamics of the system, the response is far more interesting than the linear components of the model would suggest. As expected with hybrid systems of this type, it is difficult to establish analytical results, and hence, with the assistance of an extensive series of numerical integrations, an atlas of qualitative results on the limit cycles and other forms of bounded oscillations exhibited by the system is presented. In addition, the presence of unstable limit cycles, the stabilization of the unforced system using low-frequency excitation, the peculiar nature of the response of the system to high-frequency excitation, and the implications of these results on the energy harvesting capabilities of the wave energy converter are discussed. © 2011 Springer Science+Business Media B.V.

  1. An investigation of the effect of hysteresis in a simple rainfall-runoff model

    Science.gov (United States)

    Flynn, D. P.; O'Kane, J. P.

    2009-04-01

    Multiphase porous media such as soils are known to exhibit hysteresis, e.g. in soils there is a strong hysteretic relationship between the moisture content and the matric potential and to date the Preisach model has been successful in modelling this relationship. Subsequently ODEs with Preisach hysteresis have been developed, such as a hysteretic version of Darcy's law and a hysteretic version of the linear reservoir known as the Preisach reservoir. In this paper we combine the above Hysteretic Differential Equations (HDEs) with three linear reservoirs so as to develop a simple rainfall runoff model. The model can be represented by a block diagram: Rainfall q(t) enters the soil component and either infiltrates and/or runs off when it exceeds the maximum rate of infiltration. The runoff part is fed into two linear reservoirs in series. Next, the drainage from the soil to groundwater is represented by a single linear reservoir, where the output from the soil becomes the input to the ground reservoir and vice-versa for capillary rise. Finally the groundwater and surface runoff are combined at some point and contribute to the total outflow from the catchment. Finally we investigate the effects of hysteresis in this system and compare it to the non-hysteretic case.

  2. Understanding the Ecoydrology of Mangroves: A Simple SPAC Model for Avicennia Marina

    Science.gov (United States)

    Perri, Saverio; Viola, Francesco; Valerio Noto, Leonardo; Molini, Annalisa

    2015-04-01

    Mangroves represent one of the most carbon-rich ecosystems in the Tropics, noticeably impacting ecosystem services and the economy of these regions. Whether the ability of mangroves to exclude and tolerate salt has been extensively investigated in the literature - both from the structural and functional point of view - their eco-hydrological characteristics remains largely understudied, despite the crucial link with productivity, efficient carbon storage and fluxes. In this contribution we develop a "first-order" Soil Plant Atmosphere Continuum model for Avicennia Marina, a mangrove able to adapt to hyper-arid intertidal zones and characterized by complex morphological and eco-physiological traits. Among mangroves, Avicennia marina is one of the most tolerant to salinity and arid climatic conditions. Our model, based on a simple macroscopic approach, takes into account the specific characteristics of the mangrove ecosystem and in particular, the salinity of the water in the soil and the levels of salt stress to which the plant may be subjected. Mangrove transpiration is hence obtained by solving the plant and leaf water balance and the leaf energy balance, taking explicitly into account the role of osmotic water potential and salinity in governing plant resistance to water fluxes. The SPAC model of Avicennia is hence tested against experimental data obtained from the literature, showing the reliability and effectiveness of this minimalist model in reproducing observed transpiration fluxes. Finally, sensitivity analysis is used to assess whether uncertainty on the adopted parameters could lead to significant errors in the transpiration assessment.

  3. A simple rule based model for scheduling farm management operations in SWAT

    Science.gov (United States)

    Schürz, Christoph; Mehdi, Bano; Schulz, Karsten

    2016-04-01

    For many interdisciplinary questions at the watershed scale, the Soil and Water Assessment Tool (SWAT; Arnold et al., 1998) has become an accepted and widely used tool. Despite its flexibility, the model is highly demanding when it comes to input data. At SWAT's core the water balance and the modeled nutrient cycles are plant growth driven (implemented with the EPIC crop growth model). Therefore, land use and crop data with high spatial and thematic resolution, as well as detailed information on cultivation and farm management practices are required. For many applications of the model however, these data are unavailable. In order to meet these requirements, SWAT offers the option to trigger scheduled farm management operations by applying the Potential Heat Unit (PHU) concept. The PHU concept solely takes into account the accumulation of daily mean temperature for management scheduling. Hence, it contradicts several farming strategies that take place in reality; such as: i) Planting and harvesting dates are set much too early or too late, as the PHU concept is strongly sensitivity to inter-annual temperature fluctuations; ii) The timing of fertilizer application, in SWAT this often occurs simultaneously on the same date in in each field; iii) and can also coincide with precipitation events. Particularly, the latter two can lead to strong peaks in modeled nutrient loads. To cope with these shortcomings we propose a simple rule based model (RBM) to schedule management operations according to realistic farmer management practices in SWAT. The RBM involves simple strategies requiring only data that are input into the SWAT model initially, such as temperature and precipitation data. The user provides boundaries of time periods for operation schedules to take place for all crops in the model. These data are readily available from the literature or from crop variety trials. The RBM applies the dates by complying with the following rules: i) Operations scheduled in the

  4. A simple approach to power and sample size calculations in logistic regression and Cox regression models.

    Science.gov (United States)

    Vaeth, Michael; Skovlund, Eva

    2004-06-15

    For a given regression problem it is possible to identify a suitably defined equivalent two-sample problem such that the power or sample size obtained for the two-sample problem also applies to the regression problem. For a standard linear regression model the equivalent two-sample problem is easily identified, but for generalized linear models and for Cox regression models the situation is more complicated. An approximately equivalent two-sample problem may, however, also be identified here. In particular, we show that for logistic regression and Cox regression models the equivalent two-sample problem is obtained by selecting two equally sized samples for which the parameters differ by a value equal to the slope times twice the standard deviation of the independent variable and further requiring that the overall expected number of events is unchanged. In a simulation study we examine the validity of this approach to power calculations in logistic regression and Cox regression models. Several different covariate distributions are considered for selected values of the overall response probability and a range of alternatives. For the Cox regression model we consider both constant and non-constant hazard rates. The results show that in general the approach is remarkably accurate even in relatively small samples. Some discrepancies are, however, found in small samples with few events and a highly skewed covariate distribution. Comparison with results based on alternative methods for logistic regression models with a single continuous covariate indicates that the proposed method is at least as good as its competitors. The method is easy to implement and therefore provides a simple way to extend the range of problems that can be covered by the usual formulas for power and sample size determination. Copyright 2004 John Wiley & Sons, Ltd.

  5. Simple Prediction of Type 2 Diabetes Mellitus via Decision Tree Modeling

    Directory of Open Access Journals (Sweden)

    Mehrab Sayadi

    2017-06-01

    Full Text Available Background: Type 2 Diabetes Mellitus (T2DM is one of the most important risk factors in cardiovascular disorders considered as a common clinical and public health problem. Early diagnosis can reduce the burden of the disease. Decision tree, as an advanced data mining method, can be used as a reliable tool to predict T2DM. Objectives: This study aimed to present a simple model for predicting T2DM using decision tree modeling. Materials and Methods: This analytical model-based study used a part of the cohort data obtained from a database in Healthy Heart House of Shiraz, Iran. The data included routine information, such as age, gender, Body Mass Index (BMI, family history of diabetes, and systolic and diastolic blood pressure, which were obtained from the individuals referred for gathering baseline data in Shiraz cohort study from 2014 to 2015. Diabetes diagnosis was used as binary datum. Decision tree technique and J48 algorithm were applied using the WEKA software (version 3.7.5, New Zealand. Additionally, Receiver Operator Characteristic (ROC curve and Area Under Curve (AUC were used for checking the goodness of fit. Results: The age of the 11302 cases obtained after data preparation ranged from 18 to 89 years with the mean age of 48.1 ± 11.4 years. Additionally, 51.1% of the cases were male. In the tree structure, blood pressure and age were placed where most information was gained. In our model, however, gender was not important and was placed on the final branch of the tree. Total precision and AUC were 87% and 89%, respectively. This indicated that the model had good accuracy for distinguishing patients from normal individuals. Conclusions: The results showed that T2DM could be predicted via decision tree model without laboratory tests. Thus, this model can be used in pre-clinical and public health screening programs.

  6. Simple Stellar Population Modeling of Quasar Host Galaxies with Diffusion K-Means Test Results

    Science.gov (United States)

    Mosby, Gregory; Moravec, E. A.; Tremonti, C. A.; Wolf, M. J.

    2013-01-01

    In the last decade, the correlation of the masses of supermassive black holes (SMBHs) and their host galaxy stellar spheroid velocity dispersions (the M-sigma relation) was greeted as clear evidence for the co-evolution of host galaxies and their SMBHs. However, studies in the last five years have posited that this relation could arise from central-limit properties of hierarchical formation alone. To address the question of whether and how often the SMBHs evolve with their host galaxies, it is necessary to look at galaxies whose SMBHs are actively growing—quasars—and determine the host galaxy properties. The central nuclei of quasar host galaxies complicate this type of study because their high luminosity tends to wash out their host galaxies. But, by using 3-D spectroscopy with the integral field unit (IFU) Sparsepak on the WIYN telescope, we have shown that the quasar light can be mostly isolated to one fiber in order to obtain the spectra of the quasar and the host galaxy concurrently. We can then model simultaneously the scattered quasar light and the stellar populations in the host galaxy fiber using a new simple stellar population (SSP) modeling method called diffusion k-means (DFK). The objectives of the research presented in this poster are to model synthetic quasar host galaxies using a DFK basis and a more traditional basis, compare the accuracy of both modeling methods, and test the affects of various prescriptions for masking the quasar lines in the host galaxy fiber. We present results from our SSP modeling and Markov Chain Monte Carlo (MCMC) results for DFK and traditional modeling schemes using synthetic data. By determining and then using the more robust stellar population modeling method, we can more confidently study quasar host galaxies to answer remaining questions in galaxy evolution. This work was partially supported by a National Science Foundation Graduate Fellowship (NSF Grant DGE-0718123) and through the NSF's REU program (NSF Award

  7. Recent Advances in Enzymatic Fuel Cells: Experiments and Modeling

    Directory of Open Access Journals (Sweden)

    Ivan Ivanov

    2010-04-01

    Full Text Available Enzymatic fuel cells convert the chemical energy of biofuels into electrical energy. Unlike traditional fuel cell types, which are mainly based on metal catalysts, the enzymatic fuel cells employ enzymes as catalysts. This fuel cell type can be used as an implantable power source for a variety of medical devices used in modern medicine to administer drugs, treat ailments and monitor bodily functions. Some advantages in comparison to conventional fuel cells include a simple fuel cell design and lower cost of the main fuel cell components, however they suffer from severe kinetic limitations mainly due to inefficiency in electron transfer between the enzyme and the electrode surface. In this review article, the major research activities concerned with the enzymatic fuel cells (anode and cathode development, system design, modeling by highlighting the current problems (low cell voltage, low current density, stability will be presented.

  8. BRICK v0.2, a simple, accessible, and transparent model framework for climate and regional sea-level projections

    Science.gov (United States)

    Wong, Tony E.; Bakker, Alexander M. R.; Ruckert, Kelsey; Applegate, Patrick; Slangen, Aimée B. A.; Keller, Klaus

    2017-07-01

    Simple models can play pivotal roles in the quantification and framing of uncertainties surrounding climate change and sea-level rise. They are computationally efficient, transparent, and easy to reproduce. These qualities also make simple models useful for the characterization of risk. Simple model codes are increasingly distributed as open source, as well as actively shared and guided. Alas, computer codes used in the geosciences can often be hard to access, run, modify (e.g., with regards to assumptions and model components), and review. Here, we describe the simple model framework BRICK (Building blocks for Relevant Ice and Climate Knowledge) v0.2 and its underlying design principles. The paper adds detail to an earlier published model setup and discusses the inclusion of a land water storage component. The framework largely builds on existing models and allows for projections of global mean temperature as well as regional sea levels and coastal flood risk. BRICK is written in R and Fortran. BRICK gives special attention to the model values of transparency, accessibility, and flexibility in order to mitigate the above-mentioned issues while maintaining a high degree of computational efficiency. We demonstrate the flexibility of this framework through simple model intercomparison experiments. Furthermore, we demonstrate that BRICK is suitable for risk assessment applications by using a didactic example in local flood risk management.

  9. Simple Theory for the Dynamics of Mean-Field-Like Models of Glass-Forming Fluids.

    Science.gov (United States)

    Szamel, Grzegorz

    2017-10-13

    We propose a simple theory for the dynamics of model glass-forming fluids, which should be solvable using a mean-field-like approach. The theory is based on transparent physical assumptions, which can be tested in computer simulations. The theory predicts an ergodicity-breaking transition that is identical to the so-called dynamic transition predicted within the replica approach. Thus, it can provide the missing dynamic component of the random first order transition framework. In the large-dimensional limit the theory reproduces the result of a recent exact calculation of Maimbourg et al. [Phys. Rev. Lett. 116, 015902 (2016)PRLTAO0031-900710.1103/PhysRevLett.116.015902]. Our approach provides an alternative, physically motivated derivation of this result.

  10. Diffusion of a new intermediate product in a simple ‘classical‐Schumpeterian’ model

    Science.gov (United States)

    2017-01-01

    Abstract This paper deals with the problem of new intermediate products within a simple model, where production is circular and goods enter into the production of other goods. It studies the process by which the new good is absorbed into the economy and the structural transformation that goes with it. By means of a long‐period method the forces of structural transformation are examined, in particular the shift of existing means of production towards the innovation and the mechanism of differential growth in terms of alternative techniques and their associated systems of production. We treat two important Schumpeterian topics: the question of technological unemployment and the problem of ‘forced saving’ and the related problem of an involuntary reduction of real consumption per capita. It is shown that both phenomena are potential by‐products of the transformation process. PMID:29695874

  11. Simple Theory for the Dynamics of Mean-Field-Like Models of Glass-Forming Fluids

    Science.gov (United States)

    Szamel, Grzegorz

    2017-10-01

    We propose a simple theory for the dynamics of model glass-forming fluids, which should be solvable using a mean-field-like approach. The theory is based on transparent physical assumptions, which can be tested in computer simulations. The theory predicts an ergodicity-breaking transition that is identical to the so-called dynamic transition predicted within the replica approach. Thus, it can provide the missing dynamic component of the random first order transition framework. In the large-dimensional limit the theory reproduces the result of a recent exact calculation of Maimbourg et al. [Phys. Rev. Lett. 116, 015902 (2016), 10.1103/PhysRevLett.116.015902]. Our approach provides an alternative, physically motivated derivation of this result.

  12. Bifurcation and chaos in the simple passive dynamic walking model with upper body

    Energy Technology Data Exchange (ETDEWEB)

    Li, Qingdu; Guo, Jianli [Key Laboratory of Industrial Internet of Things and Networked Control, Ministry of Education, Chongqing University of Posts and Telecommunications, Chongqing 400065 (China); Yang, Xiao-Song, E-mail: yangxs@hust.edu.cn [Department of Mathematics, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2014-09-01

    We present some rich new complex gaits in the simple walking model with upper body by Wisse et al. in [Robotica 22, 681 (2004)]. We first show that the stable gait found by Wisse et al. may become chaotic via period-doubling bifurcations. Such period-doubling routes to chaos exist for all parameters, such as foot mass, upper body mass, body length, hip spring stiffness, and slope angle. Then, we report three new gaits with period 3, 4, and 6; for each gait, there is also a period-doubling route to chaos. Finally, we show a practical method for finding a topological horseshoe in 3D Poincaré map, and present a rigorous verification of chaos from these gaits.

  13. Spike train statistics for consonant and dissonant musical accords in a simple auditory sensory model

    Science.gov (United States)

    Ushakov, Yuriy V.; Dubkov, Alexander A.; Spagnolo, Bernardo

    2010-04-01

    The phenomena of dissonance and consonance in a simple auditory sensory model composed of three neurons are considered. Two of them, here so-called sensory neurons, are driven by noise and subthreshold periodic signals with different ratio of frequencies, and its outputs plus noise are applied synaptically to a third neuron, so-called interneuron. We present a theoretical analysis with a probabilistic approach to investigate the interspike intervals statistics of the spike train generated by the interneuron. We find that tones with frequency ratios that are considered consonant by musicians produce at the third neuron inter-firing intervals statistics densities that are very distinctive from densities obtained using tones with ratios that are known to be dissonant. In other words, at the output of the interneuron, inharmonious signals give rise to blurry spike trains, while the harmonious signals produce more regular, less noisy, spike trains. Theoretical results are compared with numerical simulations.

  14. Secular Orbit Evolution in Systems with a Strong External Perturber—A Simple and Accurate Model

    Energy Technology Data Exchange (ETDEWEB)

    Andrade-Ines, Eduardo [Institute de Mécanique Céleste et des Calcul des Éphémérides—Observatoire de Paris, 77 Avenue Denfert Rochereau, F-75014 Paris (France); Eggl, Siegfried, E-mail: eandrade.ines@gmail.com, E-mail: siegfried.eggl@jpl.nasa.gov [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, 91109 Pasadena, CA (United States)

    2017-04-01

    We present a semi-analytical correction to the seminal solution for the secular motion of a planet’s orbit under gravitational influence of an external perturber derived by Heppenheimer. A comparison between analytical predictions and numerical simulations allows us to determine corrective factors for the secular frequency and forced eccentricity in the coplanar restricted three-body problem. The correction is given in the form of a polynomial function of the system’s parameters that can be applied to first-order forced eccentricity and secular frequency estimates. The resulting secular equations are simple, straight forward to use, and improve the fidelity of Heppenheimers solution well beyond higher-order models. The quality and convergence of the corrected secular equations are tested for a wide range of parameters and limits of its applicability are given.

  15. Building simple multiscale visualizations of outcrop geology using virtual reality modeling language (VRML)

    Science.gov (United States)

    Thurmond, John B.; Drzewiecki, Peter A.; Xu, Xueming

    2005-08-01

    Geological data collected from outcrop are inherently three-dimensional (3D) and span a variety of scales, from the megascopic to the microscopic. This presents challenges in both interpreting and communicating observations. The Virtual Reality Modeling Language provides an easy way for geoscientists to construct complex visualizations that can be viewed with free software. Field data in tabular form can be used to generate hierarchical multi-scale visualizations of outcrops, which can convey the complex relationships between a variety of data types simultaneously. An example from carbonate mud-mounds in southeastern New Mexico illustrates the embedding of three orders of magnitude of observation into a single visualization, for the purpose of interpreting depositional facies relationships in three dimensions. This type of raw data visualization can be built without software tools, yet is incredibly useful for interpreting and communicating data. Even simple visualizations can aid in the interpretation of complex 3D relationships that are frequently encountered in the geosciences.

  16. Simple protocols for oblivious transfer and secure identification in the noisy-quantum-storage model

    Science.gov (United States)

    Schaffner, Christian

    2010-09-01

    We present simple protocols for oblivious transfer and password-based identification which are secure against general attacks in the noisy-quantum-storage model as defined in R. König, S. Wehner, and J. Wullschleger [e-print arXiv:0906.1030]. We argue that a technical tool from König suffices to prove security of the known protocols. Whereas the more involved protocol for oblivious transfer from König requires less noise in storage to achieve security, our “canonical” protocols have the advantage of being simpler to implement and the security error is easier control. Therefore, our protocols yield higher OT rates for many realistic noise parameters. Furthermore, a proof of security of a direct protocol for password-based identification against general noisy-quantum-storage attacks is given.

  17. Simple protocols for oblivious transfer and secure identification in the noisy-quantum-storage model

    International Nuclear Information System (INIS)

    Schaffner, Christian

    2010-01-01

    We present simple protocols for oblivious transfer and password-based identification which are secure against general attacks in the noisy-quantum-storage model as defined in R. Koenig, S. Wehner, and J. Wullschleger [e-print arXiv:0906.1030]. We argue that a technical tool from Koenig et al. suffices to prove security of the known protocols. Whereas the more involved protocol for oblivious transfer from Koenig et al. requires less noise in storage to achieve security, our ''canonical'' protocols have the advantage of being simpler to implement and the security error is easier control. Therefore, our protocols yield higher OT rates for many realistic noise parameters. Furthermore, a proof of security of a direct protocol for password-based identification against general noisy-quantum-storage attacks is given.

  18. Bifurcation and chaos in the simple passive dynamic walking model with upper body

    International Nuclear Information System (INIS)

    Li, Qingdu; Guo, Jianli; Yang, Xiao-Song

    2014-01-01

    We present some rich new complex gaits in the simple walking model with upper body by Wisse et al. in [Robotica 22, 681 (2004)]. We first show that the stable gait found by Wisse et al. may become chaotic via period-doubling bifurcations. Such period-doubling routes to chaos exist for all parameters, such as foot mass, upper body mass, body length, hip spring stiffness, and slope angle. Then, we report three new gaits with period 3, 4, and 6; for each gait, there is also a period-doubling route to chaos. Finally, we show a practical method for finding a topological horseshoe in 3D Poincaré map, and present a rigorous verification of chaos from these gaits

  19. A simple heat transfer model for a heat flux plate under transient conditions

    International Nuclear Information System (INIS)

    Ryan, L.; Dale, J.D.

    1985-01-01

    Heat flux plates are used for measuring rates of heat transfer through surfaces under steady state and transient conditions. Their usual construction is to have a resistive layer bounded by thermopiles and an exterior layer for protection. If properly designed and constructed a linear relationship between the thermopile generated voltage and heat flux results and calibration under steady state conditions is straight forward. Under transient conditions however the voltage output from a heat flux plate cannot instantaneously follow the heat flux because of the thermal capacitance of the plate and the resulting time lag. In order to properly interpret the output of a heat flux plate used under transient conditions a simple heat transfer model was constructed and tested. (author)

  20. A simple analytical thermo-mechanical model for liquid crystal elastomer bilayer structures

    Directory of Open Access Journals (Sweden)

    Yun Cui

    2018-02-01

    Full Text Available The bilayer structure consisting of thermal-responsive liquid crystal elastomers (LCEs and other polymer materials with stretchable heaters has attracted much attention in applications of soft actuators and soft robots due to its ability to generate large deformations when subjected to heat stimuli. A simple analytical thermo-mechanical model, accounting for the non-uniform feature of the temperature/strain distribution along the thickness direction, is established for this type of bilayer structure. The analytical predictions of the temperature and bending curvature radius agree well with finite element analysis and experiments. The influences of the LCE thickness and the heat generation power on the bending deformation of the bilayer structure are fully investigated. It is shown that a thinner LCE layer and a higher heat generation power could yield more bending deformation. These results may help the design of soft actuators and soft robots involving thermal responsive LCEs.