WorldWideScience

Sample records for model results exhibit

  1. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Sintropie Flavio Pellegrini From 13 to 24 March 2017 CERN Meyrin, Main Building Energia imprigionata - Flavio Pellegrini. The exhibition is composed by eleven wood artworks with the expression of movement as theme. The artworks are the result of harmonics math applied to sculpture. The powerful black colour is dominated by the light source, generating reflexes and modulations. The result is a continuous variation of perspective visions. The works generate, at a first approach, an emotion of mystery and incomprehension, only a deeper contemplation lets one discover entangling and mutative details, evidencing the elegance of the lines and letting the meaning emerge. For more information : staff.association@cern.ch | Tél: 022 766 37 38

  2. Short and long term measures of anxiety exhibit opposite results.

    Directory of Open Access Journals (Sweden)

    Ehud Fonio

    Full Text Available Animal models of human diseases of the central nervous system, generalized anxiety disorder included, are essential for the study of the brain-behavior interface and obligatory for drug development; yet, these models fail to yield new insights and efficacious drugs. By increasing testing duration hundredfold and arena size tenfold, and comparing the behavior of the common animal model to that of wild mice, we raise concerns that chronic anxiety might have been measured at the wrong time, for the wrong duration, and in the wrong animal. Furthermore, the mice start the experimental session with a short period of transient adaptation to the novel environment (habituation period and a long period reflecting the respective trait of the mice. Using common measures of anxiety reveals that mice exhibit opposite results during these periods suggesting that chronic anxiety should be measured during the post-habituation period. We recommend tools for measuring the transient period, and provide suggestions for characterizing the post habituation period.

  3. Exhibition

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    China[Guangzheu] International Trade Fair for Home Textiles Date:March 18th- March 21st,2011 Venue:China Import and Export Fair Complex(Guangzhou,China) Organizers:China National Textile&Apparel Council China Foreign Trade Center(Group) China Home Textile Association China Foreign Trade Guangzhou Exhibition Corp.

  4. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    A Look of Hope Islam Mahmoud Sweity From 19 to 30 June 2017 CERN Meyrin, Main Building Islam Mahmoud Sweity Islam Mahmoud Sweity was born in 1997 at Beit Awwa, Palestine. She is currently following a course to get an Art diploma of Painting at the college of Fine Arts at An-Najah National University under the supervision of Esmat Al As'aad. Her portraits, landscapes and still life paintings are full of life and shining colours. Charged of emotional empathy they catch the attention of the viewer and are reminding us that life is beautiful and worth living in spite of all difficulties we have to go through. She participated in many exhibitions and has exposed her drawings in 2015 at CERN and in France in the framework of the exhibition "The Origin“, and in 2017 in the Former Yugoslav Republic of Macedonia, Palestina and Jordan. In this exhibition the oil paintings made in the past year will be presented. For more information : staff.association@cern.ch | T&eacu...

  5. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    Encounters Hanne Blitz From February 1st to 12th 2016 CERN Meyrin, Main Building What is our reaction to a first encounter with a tourist attraction? Contemporary Dutch painter Hanne Blitz captures visitors' responses to art and architecture, sweeping vistas and symbolic memorials. Encounters, a series of oil paintings curated specially for this CERN exhibition, depicts tourists visiting cultural highlights around the world. A thought-provoking journey not to be missed, and a tip of the hat to CERN's large Hadron Collider.

  6. A content-oriented model for science exhibit engineering

    DEFF Research Database (Denmark)

    Achiam, Marianne

    2013-01-01

    : as a means to operationalize the link between exhibit features and visitor activities; and as a template to transform scientists’ practices in the research context into visitors’ activities in the exhibit context. The resulting model of science exhibit engineering is presented and exemplified, and its...... in prompting visitors to carry out intended actions, exhibits do not necessarily promote the intended interpretations of these actions among visitors. Here, the notion of praxeology from didactics research is suggested as a model to remedy this shortcoming. The suggested role of praxeology is twofold......Recently, science museums have begun to review their educational purposes and redesign their pedagogies. At the most basic level, this entails accounting for the performance of individual exhibits, and indeed, in some cases, research indicates shortcomings in exhibit design: While often successful...

  7. Exhibit Engineering

    DEFF Research Database (Denmark)

    Mortensen, Marianne Foss

    ) a synthesis of the findings from the first two studies with findings from the literature to generate two types of results: a coherent series of suggestions for a design iteration of the studied exhibit as well as a more general normative model for exhibit engineering. Finally, another perspective...

  8. A Social Network Model Exhibiting Tunable Overlapping Community Structure

    NARCIS (Netherlands)

    Liu, D.; Blenn, N.; Van Mieghem, P.F.A.

    2012-01-01

    Social networks, as well as many other real-world networks, exhibit overlapping community structure. In this paper, we present formulas which facilitate the computation for characterizing the overlapping community structure of networks. A hypergraph representation of networks with overlapping

  9. Magnetization direction in the Heisenberg model exhibiting fractional Brownian motion

    DEFF Research Database (Denmark)

    Zhang, Zhengping; Mouritsen, Ole G.; Zuckermann, Martin J.

    1993-01-01

    The temporal magnetization-direction fluctuations in the three-dimensional classical ferromagnetic Heisenberg model have been generated by Monte Carlo simulation and analyzed by the rescaled-range method to yield the Hurst exponent H. A value of H congruent-to 1 has been found to apply...

  10. On the modelling of strength differential and anisotropy exhibited by titanium

    Science.gov (United States)

    Manopulo, Niko; Raemy, Christian; Hora, Pavel

    2016-08-01

    Modelling the response of titanium alloys under plastic deformation is challenging. In addition to strong anisotropy, these materials exhibit tension-compression asymmetry as well as anisotropic hardening even under monotonous loading conditions. The present contribution aims to propose a new modelling approach for titanium materials, by a homogeneous introduction of asymmetry into existing symmetric yield functions. Furthermore, anisotropic hardening effects are tracked describing the strain dependant yield surface evolution. The results are validated using the earing profile of deep drawn cups.

  11. Modeling Information for Three-Dimensional Space: Lessons Learned from Museum Exhibit Design.

    Science.gov (United States)

    Carliner, Saul

    2001-01-01

    Reports results of an observational study of museum exhibit design. Suggests eight communication practices from successful museum exhibit design that could be transferred to information design for the Web. (SR)

  12. Puerto Rico Experimental Model Dental Auxiliary Training Program. The Comprehensive Report, Exhibits A to F.

    Science.gov (United States)

    Puerto Rico Univ., San Juan. School of Dentistry.

    This annex supplements the Puerto Rico Experimental Model Dental Training Program Comprehensive Report (CE 028 213) and is comprised of exhibits A through F. Among the information included in the exhibits is the experimental model schedule, the schematic representation, the content display, and the course outlines for all courses in the program.…

  13. Modelling the equilibrium bed topography of submarine meanders that exhibit reversed secondary flows

    Science.gov (United States)

    Darby, Stephen E.; Peakall, Jeff

    2012-08-01

    Submarine meandering channels formed by turbidity currents are common; however, their location on the ocean floor and their inactive status make it difficult to measure process dynamics and bed morphology. Conceptual models have, therefore, instead been developed by analogy with the well understood mechanics of fluvial bends. However, unlike fluvial currents, in turbidity currents the downstream velocity maximum typically occurs near the bed and recent experimental and theoretical studies suggest that, under certain hydraulic and morphological conditions, this forces the secondary flow to exhibit the reverse sense to that encountered in fluvial bends. Herein the possible morphological implications of a reversal of secondary flow are explored by modelling the force balance on sediment grains moving through either (i) field and laboratory submarine meander bends that are known to exhibit ‘reversed' secondary flows, or (ii) inactive submarine meander bends where the nature of the secondary flow in the formative turbidity currents can be inferred to be reversed. Exploratory simulations are undertaken for a single hypothetical submarine bend with morphological properties based on nine relic meanders observed on the floor of the Gulf of Alaska. Reconstructions of secondary flow properties within the Gulf of Alaska bends indicate that they likely exhibited reversed secondary flows. Results of the exploratory simulations indicate that, unlike typical fluvial meanders, the transverse bed profile gradient of the hypothetical bend is very low and the point bar is located downstream of the bend apex.

  14. Puerto Rico Experimental Model Dental Auxiliary Training Program. The Comprehensive Report, Exhibits G to L.

    Science.gov (United States)

    Puerto Rico Univ., San Juan. School of Dentistry.

    This annex supplements the Puerto Rico Experimental Model Dental Training Program Comprehensive Report (CE 028 213) and is comprised of exhibits G through L. Among the information included in the exhibits is the evaluation reports of the commission on accreditation, the detailed curriculum, and the accredited program's scope, sequence, and course…

  15. Point Processes Modeling of Time Series Exhibiting Power-Law Statistics

    CERN Document Server

    Kaulakys, B; Gontis, V

    2010-01-01

    We consider stochastic point processes generating time series exhibiting power laws of spectrum and distribution density (Phys. Rev. E 71, 051105 (2005)) and apply them for modeling the trading activity in the financial markets and for the frequencies of word occurrences in the language.

  16. Design and creating model and interactive presentation of GEM for Microcosm Exhibition

    CERN Document Server

    Lakdee, Natthaphop

    2017-01-01

    GEM or Gas Electron Multiplier is the newer and easier way to amplify electron signal than conventional CSS. It was first created by Fabio Sauli at CERN in 1997 and was developed to get better efficiency over time. Right now, it was brought to use in many detector stations at CERN. To make GEM more publicly known, one of the ways is show in Microcosm Exhibition which is always visited by people from around the world everyday, so my main project as summer student is to design and create the model and interactive presentation which make GEM interesting and easy to understand by ordinary people.

  17. Stochastic Model of Gap Junctions Exhibiting Rectification and Multiple Closed States of Slow Gates.

    Science.gov (United States)

    Snipas, Mindaugas; Kraujalis, Tadas; Paulauskas, Nerijus; Maciunas, Kestutis; Bukauskas, Feliksas F

    2016-03-29

    Gap-junction (GJ) channels formed from connexin (Cx) proteins provide direct pathways for electrical and metabolic cell-cell communication. Earlier, we developed a stochastic 16-state model (S16SM) of voltage gating of the GJ channel containing two pairs of fast and slow gates, each operating between open (o) and closed (c) states. However, experimental data suggest that gates may in fact contain two or more closed states. We developed a model in which the slow gate operates according to a linear reaction scheme, o↔c1↔c2, where c1 and c2 are initial-closed and deep-closed states that both close the channel fully, whereas the fast gate operates between the open state and the closed state and exhibits a residual conductance. Thus, we developed a stochastic 36-state model (S36SM) of GJ channel gating that is sensitive to transjunctional voltage (Vj). To accelerate simulation and eliminate noise in simulated junctional conductance (gj) records, we transformed an S36SM into a Markov chain 36-state model (MC36SM) of GJ channel gating. This model provides an explanation for well-established experimental data, such as delayed gj recovery after Vj gating, hysteresis of gj-Vj dependence, and the low ratio of functional channels to the total number of GJ channels clustered in junctional plaques, and it has the potential to describe chemically mediated gating, which cannot be reflected using an S16SM. The MC36SM, when combined with global optimization algorithms, can be used for automated estimation of gating parameters including probabilities of c1↔c2 transitions from experimental gj-time and gj-Vj dependencies.

  18. Pseudomonas aeruginosa Aggregate Formation in an Alginate Bead Model System Exhibits In Vivo-Like Characteristics.

    Science.gov (United States)

    Sønderholm, Majken; Kragh, Kasper Nørskov; Koren, Klaus; Jakobsen, Tim Holm; Darch, Sophie E; Alhede, Maria; Jensen, Peter Østrup; Whiteley, Marvin; Kühl, Michael; Bjarnsholt, Thomas

    2017-05-01

    Alginate beads represent a simple and highly reproducible in vitro model system for diffusion-limited bacterial growth. In this study, alginate beads were inoculated with Pseudomonas aeruginosa and followed for up to 72 h. Confocal microscopy revealed that P. aeruginosa formed dense clusters similar in size to in vivo aggregates observed ex vivo in cystic fibrosis lungs and chronic wounds. Bacterial aggregates primarily grew in the bead periphery and decreased in size and abundance toward the center of the bead. Microsensor measurements showed that the O2 concentration decreased rapidly and reached anoxia ∼100 μm below the alginate bead surface. This gradient was relieved in beads supplemented with NO3(-) as an alternative electron acceptor allowing for deeper growth into the beads. A comparison of gene expression profiles between planktonic and alginate-encapsulated P. aeruginosa confirmed that the bacteria experienced hypoxic and anoxic growth conditions. Furthermore, alginate-encapsulated P. aeruginosa exhibited a lower respiration rate than the planktonic counterpart and showed a high tolerance toward antibiotics. The inoculation and growth of P. aeruginosa in alginate beads represent a simple and flexible in vivo-like biofilm model system, wherein bacterial growth exhibits central features of in vivo biofilms. This was observed by the formation of small cell aggregates in a secondary matrix with O2-limited growth, which was alleviated by the addition of NO3(-) as an alternative electron acceptor, and by reduced respiration rates, as well as an enhanced tolerance to antibiotic treatment.IMPORTANCEPseudomonas aeruginosa has been studied intensively for decades due to its involvement in chronic infections, such as cystic fibrosis and chronic wounds, where it forms biofilms. Much research has been dedicated to biofilm formation on surfaces; however, in chronic infections, most biofilms form small aggregates of cells not attached to a surface, but embedded in

  19. Towards a model for research-based exhibition development using design-based research as a framework

    DEFF Research Database (Denmark)

    Zachariassen, Maria; Magnussen, Rikke; Thiel Sandholdt, Cathrina

    2016-01-01

    practices. A research-based approach can expand understanding of exhibitions as a media, encouraging a more systematised, theory-based and documented practice. This premise forms the basis for creating a model for collaboration between research and exhibition development in a science centre context......This paper argues that a higher level of research activity is necessary at all levels in the creation of science centre exhibitions. Science centres focus greatly on their role as an informal learning space but rarely integrate learning theories or develop documented knowledge in their exhibition...... that facilitates an iterative research-based development process and that emphasises focusing on learning elements. We present a new model for developing research-based exhibitions and provide an accompanying analysis based on PULSE, a four-year project involving the development of a health promotion exhibition...

  20. Preclinical computational models: predictors of tibial insert damage patterns in total knee arthroplasty: AAOS exhibit selection.

    Science.gov (United States)

    Morra, Edward A; Heim, Christine S; Greenwald, A Seth

    2012-09-19

    Computational models that predict clinical surface damage of the tibial insert during activities of daily living are emerging as powerful tools to assess the safety and efficacy of contemporary total knee arthroplasty designs. These models have the advantage of quickly determining the performance of new designs at low cost, and they allow direct comparison with the performance of classic, clinically successful designs. This study validated finite element and kinematic modeling predictions through comparison with preclinical physical testing results, damage patterns on retrieved tibial inserts, and clinically measured knee motion. There is a mounting body of evidence to support the role of computational modeling as a preclinical tool that enables the optimization of total knee arthroplasty designs and the auditing of component quality control before large-scale manufacturing is undertaken.

  1. A Bounding Surface Plasticity Model for Intact Rock Exhibiting Size-Dependent Behaviour

    Science.gov (United States)

    Masoumi, Hossein; Douglas, Kurt J.; Russell, Adrian R.

    2016-01-01

    A new constitutive model for intact rock is presented recognising that rock strength, stiffness and stress-strain behaviour are affected by the size of the rock being subjected to loading. The model is formulated using bounding surface plasticity theory. It is validated against a new and extensive set of unconfined compression and triaxial compression test results for Gosford sandstone. The samples tested had diameters ranging from 19 to 145 mm and length-to-diameter ratios of 2. The model captures the continuous nonlinear stress-strain behaviour from initial loading, through peak strength to large shear strains, including transition from brittle to ductile behaviour. The size dependency was accounted for through a unified size effect law applied to the unconfined compressive strength—a key model input parameter. The unconfined compressive strength increases with sample size before peaking and then decreasing with further increasing sample size. Inside the constitutive model two hardening laws act simultaneously, each driven by plastic shear strains. The elasticity is stress level dependent. Simple linear loading and bounding surfaces are adopted, defined using the Mohr-Coulomb criterion, along with a non-associated flow rule. The model simulates well the stress-strain behaviour of Gosford sandstone at confining pressures ranging from 0 to 30 MPa for the variety of sample sizes considered.

  2. Model-Based Fatigue Prognosis of Fiber-Reinforced Laminates Exhibiting Concurrent Damage Mechanisms

    Science.gov (United States)

    Corbetta, M.; Sbarufatti, C.; Saxena, A.; Giglio, M.; Goebel, K.

    2016-01-01

    Prognostics of large composite structures is a topic of increasing interest in the field of structural health monitoring for aerospace, civil, and mechanical systems. Along with recent advancements in real-time structural health data acquisition and processing for damage detection and characterization, model-based stochastic methods for life prediction are showing promising results in the literature. Among various model-based approaches, particle-filtering algorithms are particularly capable in coping with uncertainties associated with the process. These include uncertainties about information on the damage extent and the inherent uncertainties of the damage propagation process. Some efforts have shown successful applications of particle filtering-based frameworks for predicting the matrix crack evolution and structural stiffness degradation caused by repetitive fatigue loads. Effects of other damage modes such as delamination, however, are not incorporated in these works. It is well established that delamination and matrix cracks not only co-exist in most laminate structures during the fatigue degradation process but also affect each other's progression. Furthermore, delamination significantly alters the stress-state in the laminates and accelerates the material degradation leading to catastrophic failure. Therefore, the work presented herein proposes a particle filtering-based framework for predicting a structure's remaining useful life with consideration of multiple co-existing damage-mechanisms. The framework uses an energy-based model from the composite modeling literature. The multiple damage-mode model has been shown to suitably estimate the energy release rate of cross-ply laminates as affected by matrix cracks and delamination modes. The model is also able to estimate the reduction in stiffness of the damaged laminate. This information is then used in the algorithms for life prediction capabilities. First, a brief summary of the energy-based damage model

  3. Dolichos biflorus exhibits anti-inflammatory and antioxidant properties in an acute inflammatory model

    Directory of Open Access Journals (Sweden)

    Limi Elizabeth Mathew

    2014-12-01

    Full Text Available Dolichos biflorus (Muthira is a branched, suberect, and downing herb, native to most parts of India, and found at altitudes of up to 1000 m, whose seeds can be cooked and eaten. Nutrition plays a key role in building immunity and preventing noncommunicable diseases to a certain extent. The purpose of this study was to evaluate the anti-inflammatory and antioxidant effects of 70% methanolic extract of seeds of D. biflorus (DME in carrageenan-induced inflammation. DME exhibited maximum percentage of oedema inhibition at a dose of 50 mg/kg at the 3rd hour of carrageenan induction. The effect was higher than that of the standard drug Voveran. The activities of cyclooxygenase, lipoxygenase, nitric oxide synthase, myeloperoxidase, and malondialdehyde showed significant (p < 0.05 reduction whereas the activities of antioxidant enzymes, vitamins C, and reduced glutathione level were increased significantly (p < 0.05 on treatment with DME. Also levels of the acute phase protein, ceruloplasmin, were brought to their normal range in DME-treated rats. Phytochemical analysis showed that the extract contains alkaloids, flavonoids, carbohydrates, proteins, and tannins, which may contribute to its anti-inflammatory and antioxidant activity. Thus the results demonstrate the potential beneficiary effect of DME on carrageenan-induced inflammation in rats.

  4. An expanded Notch-Delta model exhibiting long-range patterning and incorporating MicroRNA regulation.

    Directory of Open Access Journals (Sweden)

    Jerry S Chen

    2014-06-01

    Full Text Available Notch-Delta signaling is a fundamental cell-cell communication mechanism that governs the differentiation of many cell types. Most existing mathematical models of Notch-Delta signaling are based on a feedback loop between Notch and Delta leading to lateral inhibition of neighboring cells. These models result in a checkerboard spatial pattern whereby adjacent cells express opposing levels of Notch and Delta, leading to alternate cell fates. However, a growing body of biological evidence suggests that Notch-Delta signaling produces other patterns that are not checkerboard, and therefore a new model is needed. Here, we present an expanded Notch-Delta model that builds upon previous models, adding a local Notch activity gradient, which affects long-range patterning, and the activity of a regulatory microRNA. This model is motivated by our experiments in the ascidian Ciona intestinalis showing that the peripheral sensory neurons, whose specification is in part regulated by the coordinate activity of Notch-Delta signaling and the microRNA miR-124, exhibit a sparse spatial pattern whereby consecutive neurons may be spaced over a dozen cells apart. We perform rigorous stability and bifurcation analyses, and demonstrate that our model is able to accurately explain and reproduce the neuronal pattern in Ciona. Using Monte Carlo simulations of our model along with miR-124 transgene over-expression assays, we demonstrate that the activity of miR-124 can be incorporated into the Notch decay rate parameter of our model. Finally, we motivate the general applicability of our model to Notch-Delta signaling in other animals by providing evidence that microRNAs regulate Notch-Delta signaling in analogous cell types in other organisms, and by discussing evidence in other organisms of sparse spatial patterns in tissues where Notch-Delta signaling is active.

  5. Human Exhibitions

    DEFF Research Database (Denmark)

    Andreassen, Rikke

    From 1870s to 1910s, more than 50 exhibitions of so-called exotic people took place in Denmark. Here large numbers of people of Asian and African origin were exhibited for the entertainment and ‘education’ of a mass audience. Several of these exhibitions took place in Copenhagen Zoo. Here different...... light on the staging of exhibitions, the daily life of the exhibitees, the wider connections between shows across Europe and the thinking of the time on matters of race, science, gender and sexuality. A window onto contemporary racial understandings, the book presents interviews with the descendants...... of displayed people, connecting the attitudes and science of the past with both our (continued) modern fascination with ‘the exotic’, and contemporary language and popular culture. As such, it will be of interest to scholars of sociology, anthropology and history working in the areas of gender and sexuality...

  6. Ex vivo human skin and SZ95 sebocytes exhibit a homoeostatic interaction in a novel coculture contact model.

    Science.gov (United States)

    Nikolakis, Georgios; Seltmann, Holger; Hossini, Amir M; Makrantonaki, Evgenia; Knolle, Jürgen; Zouboulis, Christos C

    2015-07-01

    The sebaceous gland displays key functions of the human skin, such as hormone synthesis in situ, antimicrobial activity and participation to inflammatory responses. Consequently, there is an emerging need of advanced in vitro models to study complex interactions between the sebaceous gland and the other skin compartments. Despite the evolution of both full-skin organ culture and reconstructed three-dimensional skin models, no satisfactory solutions have been provided for the integration of sebaceous glands and/or sebaceous gland cells in those models, probably due to their problematic maintenance both in vitro and ex vivo. We have developed a coculture model of explant skin in direct contact with immortalized SZ95 sebocytes, which resulted in overall improved structural integrity of the epidermis, higher percentage of proliferating basal epidermal cells and reduced apoptosis of differentiating keratinocytes after 6 days, as detected by Ki67 and TUNEL staining, respectively. Furthermore SZ95 sebocytes exhibited morphological and biochemical signs of normal differentiation and lipid accumulation, while interleukin-6 expression in the supernatant of the cocultures was decreased in comparison with the control. The data provide evidence of a beneficial interaction between sebocytes and skin explants and provide the rationale for their integration in future three-dimensional skin models.

  7. Fit model between participation statement of exhibitors and visitors to improve the exhibition performance

    Directory of Open Access Journals (Sweden)

    Cristina García Magro

    2015-06-01

    Full Text Available Purpose: The aims of the paper is offers a model of analysis which allows to measure the impact on the performance of fairs, as well as the knowledge or not of the motives of participation of the visitors on the part of the exhibitors. Design/methodology: A review of the literature is established concerning two of the principal interested agents, exhibitors and visitors, focusing. The study is focused on the line of investigation referred to the motives of participation or not in a trade show. According to the information thrown by each perspectives of study, a comparative analysis is carried out in order to determine the degree of existing understanding between both. Findings: The trade shows allow to be studied from an integrated strategic marketing approach. The fit model between the reasons for participation of exhibitors and visitors offer information on the lack of an understanding between exhibitors and visitors, leading to dissatisfaction with the participation, a fact that is reflected in the fair success. The model identified shows that a strategic plan must be designed in which the reason for participation of visitor was incorporated as moderating variable of the reason for participation of exhibitors. The article concludes with the contribution of a series of proposals for the improvement of fairground results. Social implications: The fit model that improve the performance of trade shows, implicitly leads to successful achievement of targets for multiple stakeholders beyond the consideration of visitors and exhibitors. Originality/value: The integrated perspective of stakeholders allows the study of the existing relationships between the principal groups of interest, in such a way that, having knowledge on the condition of the question of the trade shows facilitates the task of the investigator in future academic works and allows that the interested groups obtain a better performance to the participation in fairs, as visitor or as

  8. Carbamate nerve agent prophylatics exhibit distinct toxicological effects in the zebrafish embryo model.

    Science.gov (United States)

    Fischer, Audrey; Wolman, Marc; Granato, Michael; Parsons, Michael; McCallion, Andrew S; Proescher, Jody; English, Emily

    2015-01-01

    Pyridostigmine bromide (PB) is an FDA-approved drug for the treatment of myasthenia gravis and a prophylactic pre-treatment for organophosphate nerve agent poisoning. Current methods for evaluating nerve agent treatments include enzymatic studies and mammalian models. Rapid whole animal screening tools for assessing the effects of nerve agent pre-treatment and post-exposure drugs represent an underdeveloped area of research. We used zebrafish as a model for acute and chronic developmental exposure to PB and two related carbamate acetylcholinesterase (AChE) inhibitors, neostigmine bromide (NB) and physostigmine (PS). Lethal doses and gross morphological phenotypes resulting from exposure to sub-lethal doses of these compounds were determined. Quantitative analyses of motility impairment and AChE enzyme inhibition were used to determine optimal dosing conditions for evaluation of the effects of carbamate exposures on neuronal development; ~50% impairment of response to startle stimuli and >50% inhibition of AChE activity were observed at 80 mMPB, 20 mM NB and 0.1 mM PS. PB induced stunted somite length, but no other phenotypic effects were observed. In contrast, NB and PS induced more severe phenotypic morphological defects than PB as well as neurite outgrowth mislocalization. Additionally, NB induced mislocalization of nicotinic acetylcholine receptors, resulting in impaired synapse formation. Taken together, these data suggest that altered patterns of neuronal connectivity contribute to the developmental neurotoxicity of carbamates and demonstrate the utility of the zebrafish model for distinguishing subtle structure-based differential effects of AChE inhibitors, which include nerve agents, pesticides and drugs. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current.

    Science.gov (United States)

    Best, Tyler K; Siarey, Richard J; Galdzicki, Zygmunt

    2007-01-01

    Down syndrome (DS) is the most common nonheritable cause of mental retardation. DS is the result of the presence of an extra chromosome 21 and its phenotype may be a consequence of overexpressed genes from that chromosome. One such gene is Kcnj6/Girk2, which encodes the G-protein-coupled inward rectifying potassium channel subunit 2 (GIRK2). We have recently shown that the DS mouse model, Ts65Dn, overexpresses GIRK2 throughout the brain and in particular the hippocampus. Here we report that this overexpression leads to a significant increase ( approximately 2-fold) in GABA(B)-mediated GIRK current in primary cultured hippocampal neurons. The dose response curves for peak and steady-state GIRK current density is significantly shifted left toward lower concentrations of baclofen in Ts65Dn neurons compared with diploid controls, consistent with increased functional expression of GIRK channels. Stationary fluctuation analysis of baclofen-induced GIRK current from Ts65Dn neurons indicated no significant change in single-channel conductance compared with diploid. However, significant increases in GIRK channel density was found in Ts65Dn neurons. In normalized baclofen-induced GIRK current and GIRK current kinetics no difference was found between diploid and Ts65Dn neurons, which suggests unimpaired mechanisms of interaction between GIRK channel and GABA(B) receptor. These results indicate that increased expression of GIRK2 containing channels have functional consequences that likely affect the balance between excitatory and inhibitory neuronal transmission.

  10. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation.

    Science.gov (United States)

    Reilly, Patrick; Winston, Charisse N; Baron, Kelsey R; Trejo, Margarita; Rockenstein, Edward M; Akers, Johnny C; Kfoury, Najla; Diamond, Marc; Masliah, Eliezer; Rissman, Robert A; Yuan, Shauna H

    2017-10-01

    Tauopathies are a class of neurodegenerative diseases, including Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, which are associated with the pathological aggregation of tau protein into neurofibrillary tangles (NFT). Studies have characterized tau as a "prion-like" protein given its ability to form distinct, stable amyloid conformations capable of transcellular and multigenerational propagation in clonal fashion. It has been proposed that progression of tauopathy could be due to the prion-like propagation of tau, suggesting the possibility that end-stage pathologies, like NFT formation, may require an instigating event such as tau seeding. To investigate this, we applied a novel human induced pluripotent stem cell (hiPSC) system we have developed to serve as a human neuronal model. We introduced the tau repeat domain (tau-RD) with P301L and V337M (tau-RD-LM) mutations into hiPSC-derived neurons and observed expression of tau-RD at levels similar to total tau in postmortem AD brains. Tau aggregation occurred without the addition of recombinant tau fibrils. The conditioned media from tau-RD cultures contained tau-RD seeds, which were capable of inducing aggregate formation in homotypic mode in non-transduced recipient neuronal cultures. The resultant NFTs were thioflavin-positive, silver stain-positive, and assumed fibrillary appearance on transmission electron microscopy (TEM) with immunogold, which revealed paired helical filament 1 (PHF1)-positive NFTs, representing possible recruitment of endogenous tau in the aggregates. Functionally, expression of tau-RD caused neurotoxicity that manifested as axon retraction, synaptic density reduction, and enlargement of lysosomes. The results of our hiPSC study were reinforced by the observation that Tau-RD-LM is excreted in exosomes, which mediated the transfer of human tau to wild-type mouse neurons in vivo. Our hiPSC human neuronal system provides a model for further studies of tau

  11. Exhibit Engineering

    DEFF Research Database (Denmark)

    Mortensen, Marianne Foss

    of tools and processes to guide the design of educational science exhibits. The guiding paradigm for this development is design-based research, which is characterised by an iterative cycle of design, enactment, and analysis. In the design phase, an educational intervention is planned and carried out based...... on a hypothesised learning process and the means of supporting it. In the enactment phase, the educational intervention is implemented (i.e. the planned lesson is taught, or the museum exhibit is opened to the public). Finally, the analysis phase establishes causality between emergent characteristics...... of the learning outcomes and the design characteristics of the intervention. The analysis process can yield two types of outcomes: Suggestions for the refinement of the specific design in question, and “humble” theory, which is theory that can guide the design of a category of educational interventions...

  12. Canine parvovirus NS1 protein exhibits anti-tumor activity in a mouse mammary tumor model.

    Science.gov (United States)

    Gupta, Shishir Kumar; Yadav, Pavan Kumar; Gandham, Ravi Kumar; Sahoo, A P; Harish, D R; Singh, Arvind Kumar; Tiwari, A K

    2016-02-02

    Many viral proteins have the ability to kill tumor cells specifically without harming the normal cells. These proteins, on ectopic expression, cause lysis or induction of apoptosis in the target tumor cells. Parvovirus NS1 is one of such proteins, which is known to kill high proliferating tumor cells. In the present study, we assessed the apoptosis inducing ability of canine parvovirus type 2 NS1 protein (CPV2.NS1) in vitro in 4T1 cells, and found it to cause significant cell death due to induction of apoptosis through intrinsic or mitochondrial pathway. Further, we also evaluated the oncolytic activity of CPV2.NS1 protein in a mouse mammary tumor model. The results suggested that CPV2.NS1 was able to inhibit the growth of 4T1 induced mouse mammary tumor as indicated by significantly reduced tumor volume, mitotic, AgNOR and PCNA indices. Further, inhibition of tumor growth was found to be because of induction of apoptosis in the tumor cells, which was evident by a significant increase in the number of TUNEL positive cells. Further, CPV2.NS1 was also able to stimulate the immune cells against the tumor antigens as indicated by the increased CD4+ and CD8+ counts in the blood of CVP2.NS1 treated mice. Further optimization of the delivery of NS1 protein and use of an adjuvant may further enhance its anti-tumor activity. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. A PVC-foam material model based on a thermodynamically elasto-plastic-damage framework exhibiting failure and crushing

    NARCIS (Netherlands)

    Gielen, A.W.J.

    2008-01-01

    A well known foam for naval sandwiches is PVC (polyvinyl chloride) foam. This foam exhibits elasto-damage behavior under tension and elasto-plastic behavior under compression. A proper material model is required for the prediction of the failure and post-failure behavior of these sandwiches during (

  14. A spiking network model of cerebellar Purkinje cells and molecular layer interneurons exhibiting irregular firing

    Directory of Open Access Journals (Sweden)

    William eLennon

    2014-12-01

    Full Text Available While the anatomy of the cerebellar microcircuit is well studied, how it implements cerebellar function is not understood. A number of models have been proposed to describe this mechanism but few emphasize the role of the vast network Purkinje cells (PKJs form with the molecular layer interneurons (MLIs – the stellate and basket cells. We propose a model of the MLI-PKJ network composed of simple spiking neurons incorporating the major anatomical and physiological features. In computer simulations, the model reproduces the irregular firing patterns observed in PKJs and MLIs in vitro and a shift toward faster, more regular firing patterns when inhibitory synaptic currents are blocked. In the model, the time between PKJ spikes is shown to be proportional to the amount of feedforward inhibition from an MLI on average. The two key elements of the model are: (1 spontaneously active PKJs and MLIs due to an endogenous depolarizing current, and (2 adherence to known anatomical connectivity along a parasagittal strip of cerebellar cortex. We propose this model to extend previous spiking network models of the cerebellum and for further computational investigation into the role of irregular firing and MLIs in cerebellar learning and function.

  15. A Stochastic model for two-station hydraulics exhibiting transient impact

    DEFF Research Database (Denmark)

    Jacobsen, Judith L.; Madsen, Henrik; Harremoës, Poul

    1997-01-01

    The objective of the paper is to interpret data on water level variation in a river affected by overflow from a sewer system during rain. The simplest possible, hydraulic description is combined with stochastic methods for data analysis and model parameter estimation. This combination of determin......The objective of the paper is to interpret data on water level variation in a river affected by overflow from a sewer system during rain. The simplest possible, hydraulic description is combined with stochastic methods for data analysis and model parameter estimation. This combination...

  16. Parallel plate model for trabecular bone exhibits volume fraction-dependant bias

    DEFF Research Database (Denmark)

    Day, J; Ding, Ming; Odgaard, A;

    2000-01-01

    Unbiased stereological methods were used in conjunction with microcomputed tomographic (micro-CT) scans of human and animal bone to investigate errors created when the parallel plate model was used to calculate morphometric parameters. Bone samples were obtained from the human proximal tibia......, canine distal femur, rat tail, and pig spine and scanned in a micro-CT scanner. Trabecular thickness, trabecular spacing, and trabecular number were calculated using the parallel plate model. Direct thickness, and spacing and connectivity density were calculated using unbiased three-dimensional methods...

  17. Modeling cavities exhibiting strong lateral confinement using open geometry Fourier modal method

    DEFF Research Database (Denmark)

    Häyrynen, Teppo; Gregersen, Niels

    2016-01-01

    We have developed a computationally efficient Fourier-Bessel expansion based open geometry formalism for modeling the optical properties of rotationally symmetric photonic nanostructures. The lateral computation domain is assumed infinite so that no artificial boundary conditions are needed. Instead...

  18. Parallel plate model for trabecular bone exhibits volume fraction-dependent bias

    NARCIS (Netherlands)

    J.S. Day (Judd); M. Ding; A. Odgaard; D.R. Sumner (Dale); I. Hvid (Ivan); H.H. Weinans (Harrie)

    2000-01-01

    textabstractUnbiased stereological methods were used in conjunction with microcomputed tomographic (micro-CT) scans of human and animal bone to investigate errors created when the parallel plate model was used to calculate morphometric parameters. Bone samples were obtained from the human proximal t

  19. A mathematical model of muscle containing heterogeneous half-sarcomeres exhibits residual force enhancement.

    Science.gov (United States)

    Campbell, Stuart G; Hatfield, P Chris; Campbell, Kenneth S

    2011-09-01

    A skeletal muscle fiber that is stimulated to contract and then stretched from L₁ to L₂ produces more force after the initial transient decays than if it is stimulated at L₂. This behavior has been well studied experimentally, and is known as residual force enhancement. The underlying mechanism remains controversial. We hypothesized that residual force enhancement could reflect mechanical interactions between heterogeneous half-sarcomeres. To test this hypothesis, we subjected a computational model of interacting heterogeneous half-sarcomeres to the same activation and stretch protocols that produce residual force enhancement in real preparations. Following a transient period of elevated force associated with active stretching, the model predicted a slowly decaying force enhancement lasting >30 seconds after stretch. Enhancement was on the order of 13% above isometric tension at the post-stretch muscle length, which agrees well with experimental measurements. Force enhancement in the model was proportional to stretch magnitude but did not depend strongly on the velocity of stretch, also in agreement with experiments. Even small variability in the strength of half-sarcomeres (2.1% standard deviation, normally distributed) was sufficient to produce a 5% force enhancement over isometric tension. Analysis of the model suggests that heterogeneity in half-sarcomeres leads to residual force enhancement by storing strain energy introduced during active stretch in distributions of bound cross-bridges. Complex interactions between the heterogeneous half-sarcomeres then dissipate this stored energy at a rate much slower than isolated cross-bridges would cycle. Given the variations in half-sarcomere length that have been observed in real muscle preparations and the stochastic variability inherent in all biological systems, half-sarcomere heterogeneity cannot be excluded as a contributing source of residual force enhancement.

  20. The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models

    Science.gov (United States)

    Pajtler, Kristian W; Sadowski, Natalie; Ackermann, Sandra; Althoff, Kristina; Schönbeck, Kerstin; Batzke, Katharina; Sch, Simonäfers; Odersky, Andrea; Heukamp, Lukas; Astrahantseff, Kathy; Künkele, Annette; Deubzer, Hedwig E; Schramm, Alexander; Spr, Annikaüssel; Thor, Theresa; Lindner, Sven; Eggert, Angelika; Fischer, Matthias; Schulte, Johannes H

    2017-01-01

    Polo-like kinase 1 (PLK1) is a serine/threonine kinase that promotes G2/M-phase transition, is expressed in elevated levels in high-risk neuroblastomas and correlates with unfavorable patient outcome. Recently, we and others have presented PLK1 as a potential drug target for neuroblastoma, and reported that the BI2536 PLK1 inhibitor showed antitumoral actvity in preclinical neuroblastoma models. Here we analyzed the effects of GSK461364, a competitive inhibitor for ATP binding to PLK1, on typical tumorigenic properties of preclinical in vitro and in vivo neuroblastoma models. GSK461364 treatment of neuroblastoma cell lines reduced cell viability and proliferative capacity, caused cell cycle arrest and massively induced apoptosis. These phenotypic consequences were induced by treatment in the low-dose nanomolar range, and were independent of MYCN copy number status. GSK461364 treatment strongly delayed established xenograft tumor growth in nude mice, and significantly increased survival time in the treatment group. These preclinical findings indicate PLK1 inhibitors may be effective for patients with high-risk or relapsed neuroblastomas with upregulated PLK1 and might be considered for entry into early phase clinical trials in pediatric patients. PMID:28036269

  1. Engineering Glass Passivation Layers -Model Results

    Energy Technology Data Exchange (ETDEWEB)

    Skorski, Daniel C.; Ryan, Joseph V.; Strachan, Denis M.; Lepry, William C.

    2011-08-08

    The immobilization of radioactive waste into glass waste forms is a baseline process of nuclear waste management not only in the United States, but worldwide. The rate of radionuclide release from these glasses is a critical measure of the quality of the waste form. Over long-term tests and using extrapolations of ancient analogues, it has been shown that well designed glasses exhibit a dissolution rate that quickly decreases to a slow residual rate for the lifetime of the glass. The mechanistic cause of this decreased corrosion rate is a subject of debate, with one of the major theories suggesting that the decrease is caused by the formation of corrosion products in such a manner as to present a diffusion barrier on the surface of the glass. Although there is much evidence of this type of mechanism, there has been no attempt to engineer the effect to maximize the passivating qualities of the corrosion products. This study represents the first attempt to engineer the creation of passivating phases on the surface of glasses. Our approach utilizes interactions between the dissolving glass and elements from the disposal environment to create impermeable capping layers. By drawing from other corrosion studies in areas where passivation layers have been successfully engineered to protect the bulk material, we present here a report on mineral phases that are likely have a morphological tendency to encrust the surface of the glass. Our modeling has focused on using the AFCI glass system in a carbonate, sulfate, and phosphate rich environment. We evaluate the minerals predicted to form to determine the likelihood of the formation of a protective layer on the surface of the glass. We have also modeled individual ions in solutions vs. pH and the addition of aluminum and silicon. These results allow us to understand the pH and ion concentration dependence of mineral formation. We have determined that iron minerals are likely to form a complete incrustation layer and we plan

  2. Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and in Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells

    Directory of Open Access Journals (Sweden)

    Laura Zambonin

    2012-01-01

    Full Text Available Caffeic, syringic, and protocatechuic acids are phenolic acids derived directly from food intake or come from the gut metabolism of polyphenols. In this study, the antioxidant activity of these compounds was at first evaluated in membrane models, where caffeic acid behaved as a very effective chain-breaking antioxidant, whereas syringic and protocatechuic acids were only retardants of lipid peroxidation. However, all three compounds acted as good scavengers of reactive species in cultured cells subjected to exogenous oxidative stress produced by low level of H2O2. Many tumour cells are characterised by increased ROS levels compared with their noncancerous counterparts. Therefore, we investigated whether phenolic acids, at low concentrations, comparable to those present in human plasma, were able to decrease basal reactive species. Results show that phenolic acids reduced ROS in a leukaemia cell line (HEL, whereas no effect was observed in normal cells, such as HUVEC. The compounds exhibited no toxicity to normal cells while they decreased proliferation in leukaemia cells, inducing apoptosis. In the debate on optimal ROS-manipulating strategies in cancer therapy, our work in leukaemia cells supports the antioxidant ROS-depleting approach.

  3. Interpreting Results from the Multinomial Logit Model

    DEFF Research Database (Denmark)

    Wulff, Jesper

    2015-01-01

    This article provides guidelines and illustrates practical steps necessary for an analysis of results from the multinomial logit model (MLM). The MLM is a popular model in the strategy literature because it allows researchers to examine strategic choices with multiple outcomes. However, there see...

  4. A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.

    Science.gov (United States)

    Maclean, Kenneth N; Sikora, Jakub; Kožich, Viktor; Jiang, Hua; Greiner, Lori S; Kraus, Eva; Krijt, Jakub; Overdier, Katherine H; Collard, Renata; Brodsky, Gary L; Meltesen, Lynne; Crnic, Linda S; Allen, Robert H; Stabler, Sally P; Elleder, Milan; Rozen, Rima; Patterson, David; Kraus, Jan P

    2010-01-01

    Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase. Inactivation of CBS results in CBS-deficient homocystinuria more commonly referred to as classical homocystinuria, which, if untreated, results in mental retardation, thromboembolic complications, and a range of connective tissue disorders. The molecular mechanisms that underlie the pathology of this disease are poorly understood. We report here the generation of a new mouse model of classical homocystinuria in which the mouse cbs gene is inactivated and that exhibits low-level expression of the human CBS transgene under the control of the human CBS promoter. This mouse model, designated "human only" (HO), exhibits severe elevations in both plasma and tissue levels of Hcy, methionine, S-adenosylmethionine, and S-adenosylhomocysteine and a concomitant decrease in plasma and hepatic levels of cysteine. HO mice exhibit mild hepatopathy but, in contrast to previous models of classical homocystinuria, do not incur hepatic steatosis, fibrosis, or neonatal death with approximately 90% of HO mice living for at least 6months. Tail bleeding determinations indicate that HO mice are in a hypercoagulative state that is significantly ameliorated by betaine treatment in a manner that recapitulates the disease as it occurs in humans. Our findings indicate that this mouse model will be a valuable tool in the study of pathogenesis in classical homocystinuria and the rational design of novel treatments. Copyright © 2010 Elsevier Inc. All rights reserved.

  5. Hydraulic fracture model comparison study: Complete results

    Energy Technology Data Exchange (ETDEWEB)

    Warpinski, N.R. [Sandia National Labs., Albuquerque, NM (United States); Abou-Sayed, I.S. [Mobil Exploration and Production Services (United States); Moschovidis, Z. [Amoco Production Co. (US); Parker, C. [CONOCO (US)

    1993-02-01

    Large quantities of natural gas exist in low permeability reservoirs throughout the US. Characteristics of these reservoirs, however, make production difficult and often economic and stimulation is required. Because of the diversity of application, hydraulic fracture design models must be able to account for widely varying rock properties, reservoir properties, in situ stresses, fracturing fluids, and proppant loads. As a result, fracture simulation has emerged as a highly complex endeavor that must be able to describe many different physical processes. The objective of this study was to develop a comparative study of hydraulic-fracture simulators in order to provide stimulation engineers with the necessary information to make rational decisions on the type of models most suited for their needs. This report compares the fracture modeling results of twelve different simulators, some of them run in different modes for eight separate design cases. Comparisons of length, width, height, net pressure, maximum width at the wellbore, average width at the wellbore, and average width in the fracture have been made, both for the final geometry and as a function of time. For the models in this study, differences in fracture length, height and width are often greater than a factor of two. In addition, several comparisons of the same model with different options show a large variability in model output depending upon the options chosen. Two comparisons were made of the same model run by different companies; in both cases the agreement was good. 41 refs., 54 figs., 83 tabs.

  6. Performance results of HESP physical model

    Science.gov (United States)

    Chanumolu, Anantha; Thirupathi, Sivarani; Jones, Damien; Giridhar, Sunetra; Grobler, Deon; Jakobsson, Robert

    2017-02-01

    As a continuation to the published work on model based calibration technique with HESP(Hanle Echelle Spectrograph) as a case study, in this paper we present the performance results of the technique. We also describe how the open parameters were chosen in the model for optimization, the glass data accuracy and handling the discrepancies. It is observed through simulations that the discrepancies in glass data can be identified but not quantifiable. So having an accurate glass data is important which is possible to obtain from the glass manufacturers. The model's performance in various aspects is presented using the ThAr calibration frames from HESP during its pre-shipment tests. Accuracy of model predictions and its wave length calibration comparison with conventional empirical fitting, the behaviour of open parameters in optimization, model's ability to track instrumental drifts in the spectrum and the double fibres performance were discussed. It is observed that the optimized model is able to predict to a high accuracy the drifts in the spectrum from environmental fluctuations. It is also observed that the pattern in the spectral drifts across the 2D spectrum which vary from image to image is predictable with the optimized model. We will also discuss the possible science cases where the model can contribute.

  7. Modeling Malaysia's Energy System: Some Preliminary Results

    Directory of Open Access Journals (Sweden)

    Ahmad M. Yusof

    2011-01-01

    Full Text Available Problem statement: The current dynamic and fragile world energy environment necessitates the development of new energy model that solely caters to analyze Malaysia’s energy scenarios. Approach: The model is a network flow model that traces the flow of energy carriers from its sources (import and mining through some conversion and transformation processes for the production of energy products to final destinations (energy demand sectors. The integration to the economic sectors is done exogeneously by specifying the annual sectoral energy demand levels. The model in turn optimizes the energy variables for a specified objective function to meet those demands. Results: By minimizing the inter temporal petroleum product imports for the crude oil system the annual extraction level of Tapis blend is projected at 579600 barrels per day. The aggregate demand for petroleum products is projected to grow at 2.1% year-1 while motor gasoline and diesel constitute 42 and 38% of the petroleum products demands mix respectively over the 5 year planning period. Petroleum products import is expected to grow at 6.0% year-1. Conclusion: The preliminary results indicate that the model performs as expected. Thus other types of energy carriers such as natural gas, coal and biomass will be added to the energy system for the overall development of Malaysia energy model.

  8. A physiological production model for cacao : results of model simulations

    NARCIS (Netherlands)

    Zuidema, P.A.; Leffelaar, P.A.

    2002-01-01

    CASE2 is a physiological model for cocoa (Theobroma cacao L.) growth and yield. This report introduces the CAcao Simulation Engine for water-limited production in a non-technical way and presents simulation results obtained with the model.

  9. A physiological production model for cacao : results of model simulations

    NARCIS (Netherlands)

    Zuidema, P.A.; Leffelaar, P.A.

    2002-01-01

    CASE2 is a physiological model for cocoa (Theobroma cacao L.) growth and yield. This report introduces the CAcao Simulation Engine for water-limited production in a non-technical way and presents simulation results obtained with the model.

  10. Modelling rainfall erosion resulting from climate change

    Science.gov (United States)

    Kinnell, Peter

    2016-04-01

    It is well known that soil erosion leads to agricultural productivity decline and contributes to water quality decline. The current widely used models for determining soil erosion for management purposes in agriculture focus on long term (~20 years) average annual soil loss and are not well suited to determining variations that occur over short timespans and as a result of climate change. Soil loss resulting from rainfall erosion is directly dependent on the product of runoff and sediment concentration both of which are likely to be influenced by climate change. This presentation demonstrates the capacity of models like the USLE, USLE-M and WEPP to predict variations in runoff and erosion associated with rainfall events eroding bare fallow plots in the USA with a view to modelling rainfall erosion in areas subject to climate change.

  11. Simulation Modeling of Radio Direction Finding Results

    Directory of Open Access Journals (Sweden)

    K. Pelikan

    1994-12-01

    Full Text Available It is sometimes difficult to determine analytically error probabilities of direction finding results for evaluating algorithms of practical interest. Probalistic simulation models are described in this paper that can be to study error performance of new direction finding systems or to geographical modifications of existing configurations.

  12. Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits In Vivo-like characteristics

    DEFF Research Database (Denmark)

    Sønderholm, Majken; Kragh, Kasper Nørskov; Koren, Klaus

    2017-01-01

    Alginate beads represent a simple and highly reproducible in vitro model system for diffusion-limited bacterial growth. In this study, alginate beads were inoculated with Pseudomonas aeruginosa and followed for up to 72 h. Confocal microscopy revealed that P. aeruginosa formed dense clusters...... and reached anoxia ∼100 μm below the alginate bead surface. This gradient was relieved in beads supplemented with NO3− as an alternative electron acceptor allowing for deeper growth into the beads. A comparison of gene expression profiles between planktonic and alginate-encapsulated P. aeruginosa confirmed...... that the bacteria experienced hypoxic and anoxic growth conditions. Furthermore, alginate-encapsulated P. aeruginosa exhibited a lower respiration rate than the planktonic counterpart and showed a high tolerance toward antibiotics. The inoculation and growth of P. aeruginosa in alginate beads represent a simple...

  13. Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis

    Science.gov (United States)

    Estes, Patricia S.; Daniel, Scott G.; Mccallum, Abigail P.; Boehringer, Ashley V.; Sukhina, Alona S.; Zwick, Rebecca A.; Zarnescu, Daniela C.

    2013-01-01

    SUMMARY Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by complex neuronal and glial phenotypes. Recently, RNA-based mechanisms have been linked to ALS via RNA-binding proteins such as TDP-43, which has been studied in vivo using models ranging from yeast to rodents. We have developed a Drosophila model of ALS based on TDP-43 that recapitulates several aspects of pathology, including motor neuron loss, locomotor dysfunction and reduced survival. Here we report the phenotypic consequences of expressing wild-type and four different ALS-linked TDP-43 mutations in neurons and glia. We show that TDP-43-driven neurodegeneration phenotypes are dose- and age-dependent. In motor neurons, TDP-43 appears restricted to nuclei, which are significantly misshapen due to mutant but not wild-type protein expression. In glia and in the developing neuroepithelium, TDP-43 associates with cytoplasmic puncta. TDP-43-containing RNA granules are motile in cultured motor neurons, although wild-type and mutant variants exhibit different kinetic properties. At the neuromuscular junction, the expression of TDP-43 in motor neurons versus glia leads to seemingly opposite synaptic phenotypes that, surprisingly, translate into comparable locomotor defects. Finally, we explore sleep as a behavioral readout of TDP-43 expression and find evidence of sleep fragmentation consistent with hyperexcitability, a suggested mechanism in ALS. These findings support the notion that although motor neurons and glia are both involved in ALS pathology, at the cellular level they can exhibit different responses to TDP-43. In addition, our data suggest that individual TDP-43 alleles utilize distinct molecular mechanisms, which will be important for developing therapeutic strategies. PMID:23471911

  14. Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis

    Directory of Open Access Journals (Sweden)

    Patricia S. Estes

    2013-05-01

    Amyotrophic lateral sclerosis (ALS is a fatal disease characterized by complex neuronal and glial phenotypes. Recently, RNA-based mechanisms have been linked to ALS via RNA-binding proteins such as TDP-43, which has been studied in vivo using models ranging from yeast to rodents. We have developed a Drosophila model of ALS based on TDP-43 that recapitulates several aspects of pathology, including motor neuron loss, locomotor dysfunction and reduced survival. Here we report the phenotypic consequences of expressing wild-type and four different ALS-linked TDP-43 mutations in neurons and glia. We show that TDP-43-driven neurodegeneration phenotypes are dose- and age-dependent. In motor neurons, TDP-43 appears restricted to nuclei, which are significantly misshapen due to mutant but not wild-type protein expression. In glia and in the developing neuroepithelium, TDP-43 associates with cytoplasmic puncta. TDP-43-containing RNA granules are motile in cultured motor neurons, although wild-type and mutant variants exhibit different kinetic properties. At the neuromuscular junction, the expression of TDP-43 in motor neurons versus glia leads to seemingly opposite synaptic phenotypes that, surprisingly, translate into comparable locomotor defects. Finally, we explore sleep as a behavioral readout of TDP-43 expression and find evidence of sleep fragmentation consistent with hyperexcitability, a suggested mechanism in ALS. These findings support the notion that although motor neurons and glia are both involved in ALS pathology, at the cellular level they can exhibit different responses to TDP-43. In addition, our data suggest that individual TDP-43 alleles utilize distinct molecular mechanisms, which will be important for developing therapeutic strategies.

  15. An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.

    NARCIS (Netherlands)

    Andressoo, Jaan-Olle; Mitchell, James R; Wit, Jan de; Hoogstraten, Deborah; Volker, Marcel; Toussaint, Wendy; Speksnijder, Ewoud; Beems, Rudolf B; Steeg, Harry van; Jans, Judith; Zeeuw, Chris I de; Jaspers, Nicolaas G J; Raams, Anja; Lehmann, Alan R; Vermeulen, Wim; Hoeijmakers, Jan H J; Horst, Gijsbertus T J van der

    2006-01-01

    Inborn defects in nucleotide excision DNA repair (NER) can paradoxically result in elevated cancer incidence (xeroderma pigmentosum [XP]) or segmental progeria without cancer predisposition (Cockayne syndrome [CS] and trichothiodystrophy [TTD]). We report generation of a knockin mouse model for the

  16. An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.

    NARCIS (Netherlands)

    Andressoo, Jaan-Olle; Mitchell, James R; Wit, Jan de; Hoogstraten, Deborah; Volker, Marcel; Toussaint, Wendy; Speksnijder, Ewoud; Beems, Rudolf B; Steeg, Harry van; Jans, Judith; Zeeuw, Chris I de; Jaspers, Nicolaas G J; Raams, Anja; Lehmann, Alan R; Vermeulen, Wim; Hoeijmakers, Jan H J; Horst, Gijsbertus T J van der

    2006-01-01

    Inborn defects in nucleotide excision DNA repair (NER) can paradoxically result in elevated cancer incidence (xeroderma pigmentosum [XP]) or segmental progeria without cancer predisposition (Cockayne syndrome [CS] and trichothiodystrophy [TTD]). We report generation of a knockin mouse model for the

  17. Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.

    Science.gov (United States)

    Osaki, Yoshinori; Nakagawa, Yoshimi; Miyahara, Shoko; Iwasaki, Hitoshi; Ishii, Akiko; Matsuzaka, Takashi; Kobayashi, Kazuto; Yatoh, Shigeru; Takahashi, Akimitsu; Yahagi, Naoya; Suzuki, Hiroaki; Sone, Hirohito; Ohashi, Ken; Ishibashi, Shun; Yamada, Nobuhiro; Shimano, Hitoshi

    2015-10-23

    HMG-CoA reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonic acid (MVA); this is the rate-limiting enzyme of the mevalonate pathway that synthesizes cholesterol. Statins, HMGCR inhibitors, are widely used as cholesterol-reducing drugs. However, statin-induced myopathy is the most adverse side effect of statins. To eludicate the mechanisms underlying statin the myotoxicity and HMGCR function in the skeletal muscle, we developed the skeletal muscle-specific HMGCR knockout mice. Knockout mice exhibited postnatal myopathy with elevated serum creatine kinase levels and necrosis. Myopathy in knockout mice was completely rescued by the oral administration of MVA. These results suggest that skeletal muscle toxicity caused by statins is dependent on the deficiencies of HMGCR enzyme activity and downstream metabolites of the mevalonate pathway in skeletal muscles rather than the liver or other organs. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. New DNS and modeling results for turbulent pipe flow

    Science.gov (United States)

    Johansson, Arne; El Khoury, George; Grundestam, Olof; Schlatter, Philipp; Brethouwer, Geert; Linne Flow Centre Team

    2013-11-01

    The near-wall region of turbulent pipe and channel flows (as well as zero-pressure gradient boundary layers) have been shown to exhibit a very high degree of similarity in terms of all statistical moments and many other features, while even the mean velocity profile in the two cases exhibits significant differences between in the outer region. The wake part of the profile, i.e. the deviation from the log-law, in the outer region is of substantially larger amplitude in pipe flow as compared to channel flow (although weaker than in boundary layer flow). This intriguing feature has been well known but has no simple explanation. Model predictions typically give identical results for the two flows. We have analyzed a new set of DNS for pipe and channel flows (el Khoury et al. 2013, Flow, Turbulence and Combustion) for friction Reynolds numbers up to 1000 and made comparing calculations with differential Reynolds stress models (DRSM). We have strong indications that the key factor behind the difference in mean velocity in the outer region can be coupled to differences in the turbulent diffusion in this region. This is also supported by DRSM results, where interesting differences are seen depending on the sophistication of modeling the turbulent diffusion coefficient.

  19. Yoga Meditation Practitioners Exhibit Greater Gray Matter Volume and Fewer Reported Cognitive Failures: Results of a Preliminary Voxel-Based Morphometric Analysis

    Directory of Open Access Journals (Sweden)

    Brett Froeliger

    2012-01-01

    Full Text Available Hatha yoga techniques, including physical postures (asanas, breathing exercises (pranayama, and meditation, involve the practice of mindfulness. In turn, yoga meditation practices may induce the state of mindfulness, which, when evoked recurrently through repeated practice, may accrue into trait or dispositional mindfulness. Putatively, these changes may be mediated by experience-dependent neuroplastic changes. Though prior studies have identified differences in gray matter volume (GMV between long-term mindfulness practitioners and controls, no studies to date have reported on whether yoga meditation is associated with GMV differences. The present study investigated GMV differences between yoga meditation practitioners (YMP and a matched control group (CG. The YMP group exhibited greater GM volume in frontal, limbic, temporal, occipital, and cerebellar regions; whereas the CG had no greater regional greater GMV. In addition, the YMP group reported significantly fewer cognitive failures on the Cognitive Failures Questionnaire (CFQ, the magnitude of which was positively correlated with GMV in numerous regions identified in the primary analysis. Lastly, GMV was positively correlated with the duration of yoga practice. Results from this preliminary study suggest that hatha yoga practice may be associated with the promotion of neuroplastic changes in executive brain systems, which may confer therapeutic benefits that accrue with repeated practice.

  20. Distinct transformation tropism exhibited by human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 is the result of postinfection T cell clonal expansion.

    Science.gov (United States)

    Kannian, Priya; Yin, Han; Doueiri, Rami; Lairmore, Michael D; Fernandez, Soledad; Green, Patrick L

    2012-04-01

    Human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 are related but pathogenically distinct viruses. HTLV-1 mainly causes adult T cell leukemia, while HTLV-2 is not associated with leukemia. In vitro, HTLV-1 and HTLV-2 predominantly transform CD4(+) and CD8(+) T cells, respectively: the genetic determinant maps to the viral envelope. Herein, we investigate whether this transformation tropism occurs during initial infection or subsequently during the cellular transformation process. Since most individuals are chronically infected at the time of detection, we utilized an established rabbit model to longitudinally measure the early HTLV-1 and HTLV-2 infection and replication kinetics in purified CD4(+) and CD8(+) T cells. HTLV-1 and HTLV-2 were detected in both CD4(+) and CD8(+) T cells within 1 week postinoculation. In HTLV-1-infected rabbit CD4(+) T cells, proviral burden and tax/rex mRNA expression peaked early, and expression levels were directly proportional to each other. The late expression of the antisense transcript (Hbz or Aph-2) correlated directly with a late proviral burden peak in HTLV-1- or HTLV-2-infected rabbit CD8(+) T cells, respectively. This study provides the first in vivo evidence that these viruses do not exhibit cellular preference during initial infection. We further evaluated the transformation tropism of HTLV-1 and HTLV-2 over a 9-week period using in vitro cell growth/immortalization assays. At the early weeks, both HTLV-1 and HTLV-2 showed proportionate growth of CD4(+) and CD8(+) T cells. However, beyond week 5, the predominance of one particular T cell type emerged, supporting the conclusion that transformation tropism is a postinfection event due to selective clonal expansion over time.

  1. The Danish national passenger modelModel specification and results

    DEFF Research Database (Denmark)

    Rich, Jeppe; Hansen, Christian Overgaard

    2016-01-01

    The paper describes the structure of the new Danish National Passenger model and provides on this basis a general discussion of large-scale model design, cost-damping and model validation. The paper aims at providing three main contributions to the existing literature. Firstly, at the general level......, the paper provides a description of a large-scale forecast model with a discussion of the linkage between population synthesis, demand and assignment. Secondly, the paper gives specific attention to model specification and in particular choice of functional form and cost-damping. Specifically we suggest...... a family of logarithmic spline functions and illustrate how it is applied in the model. Thirdly and finally, we evaluate model sensitivity and performance by evaluating the distance distribution and elasticities. In the paper we present results where the spline-function is compared with more traditional...

  2. CMS standard model Higgs boson results

    Directory of Open Access Journals (Sweden)

    Garcia-Abia Pablo

    2013-11-01

    Full Text Available In July 2012 CMS announced the discovery of a new boson with properties resembling those of the long-sought Higgs boson. The analysis of the proton-proton collision data recorded by the CMS detector at the LHC, corresponding to integrated luminosities of 5.1 fb−1 at √s = 7 TeV and 19.6 fb−1 at √s = 8 TeV, confirm the Higgs-like nature of the new boson, with a signal strength associated with vector bosons and fermions consistent with the expectations for a standard model (SM Higgs boson, and spin-parity clearly favouring the scalar nature of the new boson. In this note I review the updated results of the CMS experiment.

  3. Revisiting Runoff Model Calibration: Airborne Snow Observatory Results Allow Improved Modeling Results

    Science.gov (United States)

    McGurk, B. J.; Painter, T. H.

    2014-12-01

    Deterministic snow accumulation and ablation simulation models are widely used by runoff managers throughout the world to predict runoff quantities and timing. Model fitting is typically based on matching modeled runoff volumes and timing with observed flow time series at a few points in the basin. In recent decades, sparse networks of point measurements of the mountain snowpacks have been available to compare with modeled snowpack, but the comparability of results from a snow sensor or course to model polygons of 5 to 50 sq. km is suspect. However, snowpack extent, depth, and derived snow water equivalent have been produced by the NASA/JPL Airborne Snow Observatory (ASO) mission for spring of 20013 and 2014 in the Tuolumne River basin above Hetch Hetchy Reservoir. These high-resolution snowpack data have exposed the weakness in a model calibration based on runoff alone. The U.S. Geological Survey's Precipitation Runoff Modeling System (PRMS) calibration that was based on 30-years of inflow to Hetch Hetchy produces reasonable inflow results, but modeled spatial snowpack location and water quantity diverged significantly from the weekly measurements made by ASO during the two ablation seasons. The reason is that the PRMS model has many flow paths, storages, and water transfer equations, and a calibrated outflow time series can be right for many wrong reasons. The addition of a detailed knowledge of snow extent and water content constrains the model so that it is a better representation of the actual watershed hydrology. The mechanics of recalibrating PRMS to the ASO measurements will be described, and comparisons in observed versus modeled flow for both a small subbasin and the entire Hetch Hetchy basin will be shown. The recalibrated model provided a bitter fit to the snowmelt recession, a key factor for water managers as they balance declining inflows with demand for power generation and ecosystem releases during the final months of snow melt runoff.

  4. Human umbilical cord mesenchymal stem cells and derived hepatocyte-like cells exhibit similar therapeutic effects on an acute liver failure mouse model.

    Directory of Open Access Journals (Sweden)

    Ruiping Zhou

    Full Text Available Mesenchymal stem cells (MSCs have exhibited therapeutic effects in multiple animal models so that are promising liver substitute for transplantation treatment of end-stage liver diseases. However, it has been shown that over-manipulation of these cells increased their tumorigenic potential, and that reducing the in vitro culture time could minimize the risk. In this study, we used a D-galactosamine plus lipopolysaccharide (Gal/LPS-induced acute liver failure mouse model, which caused death of about 50% of the mice with necrosis of more than 50% hepatocytes, to compare the therapeutic effects of human umbilical cord MSCs (hUCMSCs before and after induction of differentiation into hepatocyte (i-Heps. Induction of hUCMSCs to become i-Heps was achieved by treatment of the cells with a group of growth factors within 4 weeks. The resulted i-Heps exhibited a panel of human hepatocyte biomarkers including cytokeratin (hCK-18, α-fetoprotein (hAFP, albumin (hALB, and hepatocyte-specific functions glycogen storage and urea metabolism. We demonstrated that transplantation of both cell types through tail vein injection rescued almost all of the Gal/LPS-intoxicated mice. Although both cell types exhibited similar ability in homing at the mouse livers, the populations of the hUCMSCs-derived cells, as judged by expressing hAFP, hCK-18 and human hepatocyte growth factor (hHGF, were small. These observations let us to conclude that the hUCMSCs was as effective as the i-Heps in treatment of the mouse acute liver failure, and that the therapeutic effects of hUCMSCs were mediated largely via stimulation of host hepatocyte regeneration, and that delivery of the cells through intravenous injection was effective.

  5. Modeling Malaysia's Energy System: Some Preliminary Results

    OpenAIRE

    Ahmad M. Yusof

    2011-01-01

    Problem statement: The current dynamic and fragile world energy environment necessitates the development of new energy model that solely caters to analyze Malaysias energy scenarios. Approach: The model is a network flow model that traces the flow of energy carriers from its sources (import and mining) through some conversion and transformation processes for the production of energy products to final destinations (energy demand sectors). The integration to the economic sectors is done exogene...

  6. In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models.

    Science.gov (United States)

    Yao, B B; Hsieh, G C; Frost, J M; Fan, Y; Garrison, T R; Daza, A V; Grayson, G K; Zhu, C Z; Pai, M; Chandran, P; Salyers, A K; Wensink, E J; Honore, P; Sullivan, J P; Dart, M J; Meyer, M D

    2008-01-01

    Selective cannabinoid CB2 receptor agonists have demonstrated analgesic activity across multiple preclinical pain models. AM1241 is an indole derivative that exhibits high affinity and selectivity for the CB2 binding site and broad spectrum analgesic activity in rodent models, but is not an antagonist of CB2 in vitro functional assays. Additionally, its analgesic effects are mu-opioid receptor-dependent. Herein, we describe the in vitro and in vivo pharmacological properties of A-796260, a novel CB2 agonist. A-796260 was characterized in radioligand binding and in vitro functional assays at rat and human CB1 and CB2 receptors. The behavioural profile of A-796260 was assessed in models of inflammatory, post-operative, neuropathic, and osteoarthritic (OA) pain, as well as its effects on motor activity. The receptor specificity was confirmed using selective CB1, CB2 and mu-opioid receptor antagonists. A-796260 exhibited high affinity and agonist efficacy at human and rat CB2 receptors, and was selective for the CB2 vs CB1 subtype. Efficacy in models of inflammatory, post-operative, neuropathic and OA pain was demonstrated, and these activities were selectively blocked by CB2, but not CB1 or mu-opioid receptor-selective antagonists. Efficacy was achieved at doses that had no significant effects on motor activity. These results further confirm the therapeutic potential of CB2 receptor-selective agonists for the treatment of pain. In addition, they demonstrate that A-796260 may be a useful new pharmacological compound for further studying CB2 receptor pharmacology and for evaluating its role in the modulation of pain.

  7. Quantitative magnetospheric models: results and perspectives.

    Science.gov (United States)

    Kuznetsova, M.; Hesse, M.; Gombosi, T.; Csem Team

    Global magnetospheric models are indispensable tool that allow multi-point measurements to be put into global context Significant progress is achieved in global MHD modeling of magnetosphere structure and dynamics Medium resolution simulations confirm general topological pictures suggested by Dungey State of the art global models with adaptive grids allow performing simulations with highly resolved magnetopause and magnetotail current sheet Advanced high-resolution models are capable to reproduced transient phenomena such as FTEs associated with formation of flux ropes or plasma bubbles embedded into magnetopause and demonstrate generation of vortices at magnetospheric flanks On the other hand there is still controversy about the global state of the magnetosphere predicted by MHD models to the point of questioning the length of the magnetotail and the location of the reconnection sites within it For example for steady southwards IMF driving condition resistive MHD simulations produce steady configuration with almost stationary near-earth neutral line While there are plenty of observational evidences of periodic loading unloading cycle during long periods of southward IMF Successes and challenges in global modeling of magnetispheric dynamics will be addessed One of the major challenges is to quantify the interaction between large-scale global magnetospheric dynamics and microphysical processes in diffusion regions near reconnection sites Possible solutions to controversies will be discussed

  8. Droplet Lamp Design exhibition

    OpenAIRE

    Unver, Ertu; Dean, Lionel Theodore

    2011-01-01

    This paper describes experiments in the use of digital fluid simulation techniques within a\\ud product design context. It discusses the adoption and adaptation of virtual modelling tools in\\ud 3D creative practice. This work is exhibited at EuroMold, the world-wide fair in Germany for\\ud mold making, tooling, design and application development with around 60.000 visitors and lasts\\ud 4 days. The fair brings together professionals from design, prototyping and manufacturing.

  9. Novel BAC mouse model of Huntington’s disease with 225 CAG repeats exhibits an early widespread and stable degenerative phenotype

    Science.gov (United States)

    Wegrzynowicz, Michal; Bichell, Terry Jo; Soares, Barbara D.; Loth, Meredith K.; McGlothan, Jennifer L.; Alikhan, Fatima S.; Hua, Kegang; Coughlin, Jennifer M.; Holt, Hunter K.; Jetter, Christopher S.; Mori, Susumu; Pomper, Martin G.; Osmand, Alexander P.; Guilarte, Tomás R.; Bowman, Aaron B.

    2015-01-01

    BACKGROUND Unusually large CAG repeat expansions (>60) in exon one of Huntingtin (HTT) are invariably associated with a juvenile-onset form of Huntington’s disease (HD), characterized by a more extensive and rapidly progressing neuropathology than the more prevalent adult-onset form. However, existing mouse models of HD that express the full-length Htt gene with CAG repeat lengths associated with juvenile HD (ranging between ~75 to ~150 repeats in published models) exhibit selective neurodegenerative phenotypes more consistent with adult-onset HD. OBJECTIVE To determine if a very large CAG repeat (>200) in full-length Htt elicits neurodegenerative phenotypes consistent with juvenile HD. METHODS Using a bacterial artificial chromosome (BAC) system, we generated mice expressing full-length mouse Htt with ~225 CAG repeats under control of the mouse Htt promoter. Mice were characterized using behavioral, neuropathological, biochemical and brain imaging methods. RESULTS BAC-225Q mice exhibit phenotypes consistent with a subset of features seen in juvenile-onset HD: very early motor behavior abnormalities, reduced body weight, widespread and progressive increase in Htt aggregates, gliosis, and neurodegeneration. Early striatal pathology was observed, including reactive gliosis and loss of dopamine receptors, prior to detectable volume loss. HD-related blood markers of impaired energy metabolism and systemic inflammation were also increased. Aside from an age-dependent progression of diffuse nuclear aggregates at 6 months of age to abundant neuropil aggregates at 12 months of age, other pathological and motor phenotypes showed little to no progression. CONCLUSIONS The HD phenotypes present in animals 3 to 12 months of age make the BAC-225Q mice a unique and stable model of full-length mutant Htt associated phenotypes, including body weight loss, behavioral impairment and HD-like neurodegenerative phenotypes characteristic of juvenile-onset HD and/or late-stage adult

  10. An in vitro model for dengue virus infection that exhibits human monocyte infection, multiple cytokine production and dexamethasone immunomodulation

    Directory of Open Access Journals (Sweden)

    Sônia Regina Nogueira Ignácio Reis

    2007-12-01

    Full Text Available An important cytokine role in dengue fever pathogenesis has been described. These molecules can be associated with haemorrhagic manifestations, coagulation disorders, hypotension and shock, all symptoms implicated in vascular permeability and disease worsening conditions. Several immunological diseases have been treated by cytokine modulation and dexamethasone is utilized clinically to treat pathologies with inflammatory and autoimmune ethiologies. We established an in vitro model with human monocytes infected by dengue virus-2 for evaluating immunomodulatory and antiviral activities of potential pharmaceutical products. Flow cytometry analysis demonstrated significant dengue antigen detection in target cells two days after infection. TNF-alpha, IFN-alpha, IL-6 and IL-10 are produced by in vitro infected monocytes and are significantly detected in cell culture supernatants by multiplex microbead immunoassay. Dexamethasone action was tested for the first time for its modulation in dengue infection, presenting optimistic results in both decreasing cell infection rates and inhibiting TNF-alpha, IFN-alpha and IL-10 production. This model is proposed for novel drug trials yet to be applyed for dengue fever.

  11. An in vitro model for dengue virus infection that exhibits human monocyte infection, multiple cytokine production and dexamethasone immunomodulation.

    Science.gov (United States)

    Reis, Sônia Regina Nogueira Ignácio; Sampaio, André Luiz Franco; Henriques, Maria das Graças Muller; Gandini, Mariana; Azeredo, Elzinandes Leal; Kubelka, Claire Fernandes

    2007-12-01

    An important cytokine role in dengue fever pathogenesis has been described. These molecules can be associated with haemorrhagic manifestations, coagulation disorders, hypotension and shock, all symptoms implicated in vascular permeability and disease worsening conditions. Several immunological diseases have been treated by cytokine modulation and dexamethasone is utilized clinically to treat pathologies with inflammatory and autoimmune etiologies. We established an in vitro model with human monocytes infected by dengue virus-2 for evaluating immunomodulatory and antiviral activities of potential pharmaceutical products. Flow cytometry analysis demonstrated significant dengue antigen detection in target cells two days after infection. TNF-alpha, IFN-alpha, IL-6 and IL-10 are produced by in vitro infected monocytes and are significantly detected in cell culture supernatants by multiplex microbead immunoassay. Dexamethasone action was tested for the first time for its modulation in dengue infection, presenting optimistic results in both decreasing cell infection rates and inhibiting TNF-alpha, IFN-alpha and IL-10 production. This model is proposed for novel drug trials yet to be applied for dengue fever.

  12. Lingonberry (Vaccinium vitis-idaea L. Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity

    Directory of Open Access Journals (Sweden)

    Hoda M. Eid

    2014-01-01

    Full Text Available Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes. In a previous study, the ethanol extract of berries of V. vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK pathway. The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes. C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO were used. Treatment began by adding V. vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg for a subsequent period of 8 weeks (total HFD, 16 weeks. The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model. This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle. V. vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways. The results of the present study confirm that V. vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies.

  13. Modeling clicks beyond the first result page

    NARCIS (Netherlands)

    Chuklin, A.; Serdyukov, P.; de Rijke, M.

    2013-01-01

    Most modern web search engines yield a list of documents of a fixed length (usually 10) in response to a user query. The next ten search results are usually available in one click. These documents either replace the current result page or are appended to the end. Hence, in order to examine more

  14. Modeling clicks beyond the first result page

    NARCIS (Netherlands)

    Chuklin, A.; Serdyukov, P.; de Rijke, M.

    2013-01-01

    Most modern web search engines yield a list of documents of a fixed length (usually 10) in response to a user query. The next ten search results are usually available in one click. These documents either replace the current result page or are appended to the end. Hence, in order to examine more docu

  15. Engineering model development and test results

    Science.gov (United States)

    Wellman, John A.

    1993-08-01

    The correctability of the primary mirror spherical error in the Wide Field/Planetary Camera (WF/PC) is sensitive to the precise alignment of the incoming aberrated beam onto the corrective elements. Articulating fold mirrors that provide +/- 1 milliradian of tilt in 2 axes are required to allow for alignment corrections in orbit as part of the fix for the Hubble space telescope. An engineering study was made by Itek Optical Systems and the Jet Propulsion Laboratory (JPL) to investigate replacement of fixed fold mirrors within the existing WF/PC optical bench with articulating mirrors. The study contract developed the base line requirements, established the suitability of lead magnesium niobate (PMN) actuators and evaluated several tilt mechanism concepts. Two engineering model articulating mirrors were produced to demonstrate the function of the tilt mechanism to provide +/- 1 milliradian of tilt, packaging within the space constraints and manufacturing techniques including the machining of the invar tilt mechanism and lightweight glass mirrors. The success of the engineering models led to the follow on design and fabrication of 3 flight mirrors that have been incorporated into the WF/PC to be placed into the Hubble Space Telescope as part of the servicing mission scheduled for late 1993.

  16. Parallel Exhibits: Combining Physical and Virtual Exhibits

    NARCIS (Netherlands)

    L. Lischke; T. Dingler; S. Schneegaß; A. Schmidt; M. van der Vaart; P. Wozniak

    2014-01-01

    People have a special fascination for original physical objects, their texture, and visible history. However, the digitization of exhibits and the use of these data is a current challenge for museums. We believe that museums need to capitalize on the affordances of physical exhibits to help users na

  17. Microplasticity of MMC. Experimental results and modelling

    Energy Technology Data Exchange (ETDEWEB)

    Maire, E. (Groupe d' Etude de Metallurgie Physique et de Physique des Materiaux, INSA, 69 Villeurbanne (France)); Lormand, G. (Groupe d' Etude de Metallurgie Physique et de Physique des Materiaux, INSA, 69 Villeurbanne (France)); Gobin, P.F. (Groupe d' Etude de Metallurgie Physique et de Physique des Materiaux, INSA, 69 Villeurbanne (France)); Fougeres, R. (Groupe d' Etude de Metallurgie Physique et de Physique des Materiaux, INSA, 69 Villeurbanne (France))

    1993-11-01

    The microplastic behavior of several MMC is investigated by means of tension and compression tests. This behavior is assymetric : the proportional limit is higher in tension than in compression but the work hardening rate is higher in compression. These differences are analysed in terms of maxium of the Tresca's shear stress at the interface (proportional limit) and of the emission of dislocation loops during the cooling (work hardening rate). On another hand, a model is proposed to calculate the value of the yield stress, describing the composite as a material composed of three phases : inclusion, unaffected matrix and matrix surrounding the inclusion having a gradient in the density of the thermally induced dilocations. (orig.).

  18. Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer

    Directory of Open Access Journals (Sweden)

    McDougall Gordon

    2007-01-01

    Full Text Available Abstract Background There is a probable association between consumption of fruit and vegetables and reduced risk of cancer, particularly cancer of the digestive tract. This anti-cancer activity has been attributed in part to anti-oxidants present in these foods. Raspberries in particular are a rich source of the anti-oxidant compounds, such as polyphenols, anthocyanins and ellagitannins. Methods A "colon-available" raspberry extract (CARE was prepared that contained phytochemicals surviving a digestion procedure that mimicked the physiochemical conditions of the upper gastrointestinal tract. The polyphenolic-rich extract was assessed for anti-cancer properties in a series of in vitro systems that model important stages of colon carcinogenesis, initiation, promotion and invasion. Results The phytochemical composition of CARE was monitored using liquid chromatography mass spectrometry. The colon-available raspberry extract was reduced in anthocyanins and ellagitannins compared to the original raspberry juice but enriched in other polyphenols and polyphenol breakdown products that were more stable to gastrointestinal digestion. Initiation – CARE caused significant protective effects against DNA damage induced by hydrogen peroxide in HT29 colon cancer cells measured using single cell microgelelectrophoresis. Promotion – CARE significantly decreased the population of HT29 cells in the G1 phase of the cell cycle, effectively reducing the number of cells entering the cell cycle. However, CARE had no effect on epithelial integrity (barrier function assessed by recording the trans-epithelial resistance (TER of CACO-2 cell monolayers. Invasion – CARE caused significant inhibition of HT115 colon cancer cell invasion using the matrigel invasion assay. Conclusion The results indicate that raspberry phytochemicals likely to reach the colon are capable of inhibiting several important stages in colon carcinogenesis in vitro.

  19. Pseudouridine synthase 1 deficient mice, a model for Mitochondrial Myopathy with Sideroblastic Anemia, exhibit muscle morphology and physiology alterations

    Science.gov (United States)

    Mangum, Joshua E.; Hardee, Justin P.; Fix, Dennis K.; Puppa, Melissa J.; Elkes, Johnathon; Altomare, Diego; Bykhovskaya, Yelena; Campagna, Dean R.; Schmidt, Paul J.; Sendamarai, Anoop K.; Lidov, Hart G. W.; Barlow, Shayne C.; Fischel-Ghodsian, Nathan; Fleming, Mark D.; Carson, James A.; Patton, Jeffrey R.

    2016-01-01

    Mitochondrial myopathy with lactic acidosis and sideroblastic anemia (MLASA) is an oxidative phosphorylation disorder, with primary clinical manifestations of myopathic exercise intolerance and a macrocytic sideroblastic anemia. One cause of MLASA is recessive mutations in PUS1, which encodes pseudouridine (Ψ) synthase 1 (Pus1p). Here we describe a mouse model of MLASA due to mutations in PUS1. As expected, certain Ψ modifications were missing in cytoplasmic and mitochondrial tRNAs from Pus1−/− animals. Pus1−/− mice were born at the expected Mendelian frequency and were non-dysmorphic. At 14 weeks the mutants displayed reduced exercise capacity. Examination of tibialis anterior (TA) muscle morphology and histochemistry demonstrated an increase in the cross sectional area and proportion of myosin heavy chain (MHC) IIB and low succinate dehydrogenase (SDH) expressing myofibers, without a change in the size of MHC IIA positive or high SDH myofibers. Cytochrome c oxidase activity was significantly reduced in extracts from red gastrocnemius muscle from Pus1−/− mice. Transmission electron microscopy on red gastrocnemius muscle demonstrated that Pus1−/− mice also had lower intermyofibrillar mitochondrial density and smaller mitochondria. Collectively, these results suggest that alterations in muscle metabolism related to mitochondrial content and oxidative capacity may account for the reduced exercise capacity in Pus1−/− mice. PMID:27197761

  20. Britain exhibition at CERN

    CERN Multimedia

    Bertin; CERN PhotoLab

    1969-01-01

    The United Kingdom inaugurated the Industrial Exhibitions in 1968, and it wasn't till 1971 that other countries staged exhibitions at CERN. This photo was taken in 1969, at the second British exhibition, where 16 companies were present.

  1. MODELING RESULTS FROM CESIUM ION EXCHANGE PROCESSING WITH SPHERICAL RESINS

    Energy Technology Data Exchange (ETDEWEB)

    Nash, C.; Hang, T.; Aleman, S.

    2011-01-03

    Ion exchange modeling was conducted at the Savannah River National Laboratory to compare the performance of two organic resins in support of Small Column Ion Exchange (SCIX). In-tank ion exchange (IX) columns are being considered for cesium removal at Hanford and the Savannah River Site (SRS). The spherical forms of resorcinol formaldehyde ion exchange resin (sRF) as well as a hypothetical spherical SuperLig{reg_sign} 644 (SL644) are evaluated for decontamination of dissolved saltcake wastes (supernates). Both SuperLig{reg_sign} and resorcinol formaldehyde resin beds can exhibit hydraulic problems in their granular (nonspherical) forms. SRS waste is generally lower in potassium and organic components than Hanford waste. Using VERSE-LC Version 7.8 along with the cesium Freundlich/Langmuir isotherms to simulate the waste decontamination in ion exchange columns, spherical SL644 was found to reduce column cycling by 50% for high-potassium supernates, but sRF performed equally well for the lowest-potassium feeds. Reduced cycling results in reduction of nitric acid (resin elution) and sodium addition (resin regeneration), therefore, significantly reducing life-cycle operational costs. These findings motivate the development of a spherical form of SL644. This work demonstrates the versatility of the ion exchange modeling to study the effects of resin characteristics on processing cycles, rates, and cold chemical consumption. The value of a resin with increased selectivity for cesium over potassium can be assessed for further development.

  2. The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans.

    Science.gov (United States)

    Marks, Wendie N; Cavanagh, Mary E; Greba, Quentin; Cain, Stuart M; Snutch, Terrance P; Howland, John G

    2016-01-01

    Behavioural, neurological, and genetic similarities exist in epilepsies, their psychiatric comorbidities, and various psychiatric illnesses, suggesting common aetiological factors. Rodent models of epilepsy are used to characterize the comorbid symptoms apparent in epilepsy and their neurobiological mechanisms. The present study was designed to assess Pavlovian fear conditioning and latent inhibition in a polygenetic rat model of absence epilepsy, i.e. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and the non-epileptic control (NEC) strain. Electrophysiological recordings confirmed the presence of spike-wave discharges in young adult GAERS but not NEC rats. A series of behavioural tests designed to assess anxiety-like behaviour (elevated plus maze, open field, acoustic startle response) and cognition (Pavlovian conditioning and latent inhibition) was subsequently conducted on male and female offspring. Results showed that GAERS exhibited significantly higher anxiety-like behaviour, a characteristic reported previously. In addition, using two protocols that differed in shock intensity, we found that both sexes of GAERS displayed exaggerated cued and contextual Pavlovian fear conditioning and impaired fear extinction. Fear reinstatement to the conditioned stimuli following unsignalled footshocks did not differ between the strains. Male GAERS also showed impaired latent inhibition in a paradigm using Pavlovian fear conditioning, suggesting that they may have altered attention, particularly related to previously irrelevant stimuli in the environment. Neither the female GAERS nor NEC rats showed evidence of latent inhibition in our paradigm. Together, the results suggest that GAERS may be a particularly useful model for assessing therapeutics designed to improve the emotional and cognitive disturbances associated with absence epilepsy.

  3. A model for the scattering of high-frequency electromagnetic fields from dielectrics exhibiting thermally-activated electrical losses

    Science.gov (United States)

    Hann, Raiford E.

    1991-01-01

    An equivalent circuit model (ECM) approach is used to predict the scattering behavior of temperature-activated, electrically lossy dielectric layers. The total electrical response of the dielectric (relaxation + conductive) is given by the ECM and used in combination with transmission line theory to compute reflectance spectra for a Dallenbach layer configuration. The effects of thermally-activated relaxation processes on the scattering properties is discussed. Also, the effect of relaxation and conduction activation energy on the electrical properties of the dielectric is described.

  4. Online Exhibits & Concept Maps

    Science.gov (United States)

    Douma, M.

    2009-12-01

    , teachers, artists, and web designers, a smaller scale collaborative effort can result in an effective mini-exhibit. Online concept maps can present a large quantity of information in bite-size chunks, demonstrating interrelationships between pieces of information without inundating visitors. SpicyNodes uses radial mapping technology to enable visitors to learn about a topic or search for information in intuitive and organic ways. This online concept mapping tool can be used as a portal to invite exploration into topics, or as a means of displaying hierarchies of information. With nodes that contain text, audio, video, and links, interactive online concept maps especially engage visual, kinesthetic, and nonlinear learners. SpicyNodes is also useful for scientists who wish to complement papers, chapters, and books with an online interface that is especially appealing to nonlinear learners. Essentially, SpicyNodes shifts the burden of discovery from the reader to the author. For example, the author may create a nodemap on climate change with hundreds of nodes, but as visitors drill through the nodemap for information (e.g. from climate change to atmospheric gases to carbon dioxide), they see only a few nodes at a time and are not overwhelmed.

  5. Quantifying Stress Using mDFA: Heartbeats Exhibit Stress/Fear/Anxiety in Animal Model and Humans

    Directory of Open Access Journals (Sweden)

    Toru Yazawa

    2015-08-01

    Full Text Available Stress has not been fully defined in terms of neuroscience. But, it might be possible to quantify it, like body temperature. The aim of this study was to develop a method to quantify stress, fear and anxiety that has not been accomplished. In the present study, we present a method to quantify them using the biomedical vital information, i.e., the timing of heartbeat. Here electrocardiograms of both animal models and humans were analyzed by modified detrended fluctuation analysis (mDFA, which calculates a scaling exponent (SI from the heartbeat interval time series. The SI was able to numerically distinguish between normal and abnormal hearts. SI values varied with heart conditions, i.e., healthy basal or stressful conditions. This study suggests that mDFA has potential as a practical method for the construction of a device for health management.

  6. Chiral mercaptoacetamides display enantioselective inhibition of histone deacetylase 6 and exhibit neuroprotection in cortical neuron models of oxidative stress.

    Science.gov (United States)

    Kalin, Jay H; Zhang, Hankun; Gaudrel-Grosay, Sophie; Vistoli, Giulio; Kozikowski, Alan P

    2012-03-05

    Mercaptoacetamide-based ligands have been designed as a new class of histone deacetylase (HDAC) inhibitors for possible use in the treatment of neurodegenerative diseases. The thiol group of these compounds provides a key binding element for interaction with the catalytic zinc ion, and thus differs from the more typically employed hydroxamic acid based zinc binding groups. Herein we disclose the chemistry and biology of some substituted mercaptoacetamides with the intention of increasing HDAC6 isoform selectivity while maintaining potency similar to their hydroxamic acid analogues. The introduction of a stereocenter α to the thiol group was found to have a considerable impact on HDAC inhibitor potency. These new compounds were also profiled for their therapeutic potential in an in vitro model of stress-induced neuronal injury and were found to act as nontoxic neuroprotective agents. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Photonics of a conjugated organometallic Pt-Ir polymer and its model compounds exhibiting hybrid CT excited states.

    Science.gov (United States)

    Soliman, Ahmed M; Fortin, Daniel; Zysman-Colman, Eli; Harvey, Pierre D

    2012-04-13

    Trans- dichlorobis(tri-n-butylphosphine)platinum(II) reacts with bis(2- phenylpyridinato)-(5,5'-diethynyl-2,2'-bipyridine)iridium(III) hexafluorophosphate to form the luminescent conjugated polymer poly[trans-[(5,5'-ethynyl-2,2'-bipyridine)bis(2- phenylpyridinato)-iridium(III)]bis(tri-n-butylphosphine)platinum(II)] hexafluorophosphate ([Pt]-[Ir])n. Gel permeation chromatography indicates a degree of polymerization of 9 inferring the presence of an oligomer. Comparison of the absorption and emission band positions and their temperature dependence, emission quantum yields, and lifetimes with those for models containing only the [Pt] or the [Ir] units indicates hybrid excited states including features from both chromophores.

  8. The antineoplastic antibiotic taurolidine promotes lung and liver metastasis in two syngeneic osteosarcoma mouse models and exhibits severe liver toxicity.

    Science.gov (United States)

    Arlt, Matthias J E; Walters, Denise K; Banke, Ingo J; Steinmann, Patrick; Puskas, Gabor J; Bertz, Josefine; Rentsch, Katharina M; Ehrensperger, Felix; Born, Walter; Fuchs, Bruno

    2012-09-01

    Osteosarcoma (OS) is the most frequent primary bone tumor. Despite multiagent neoadjuvant chemotherapy, patients with metastatic disease have a poor prognosis. Moreover, currently used chemotherapeutics have severe toxic side effects. Thus, novel agents with improved antimetastatic activity and reduced toxicity are needed. Taurolidine, a broad-spectrum antimicrobial, has recently been shown to have antineoplastic properties against a variety of tumors and low systemic toxicity. Consequently, we investigated in our study the antineoplastic potential of taurolidine against OS in two different mouse models. Although both OS cell lines, K7M2 and LM8, were sensitive for the compound in vitro, intraperitoneal application of taurolidine failed to inhibit primary tumor growth. Moreover, it enhanced the metastatic load in both models 1.7- to 20-fold and caused severe liver deformations and up to 40% mortality. Thus, systemic toxicity was further investigated in tumor-free mice histologically, by electron microscopy and by measurements of representative liver enzymes. Taurolidine dose-dependent fibrous thickening of the liver capsule and adhesions and atrophies of the liver lobes were comparable in healthy and tumor-bearing mice. Liver toxicity was further indicated by up to eightfold elevated levels of the liver enzymes alanine transaminase, aspartate transaminase and GLDH in the circulation. Ultrastructural analysis of affected liver tissue showed swollen mitochondria with cristolysis and numerous lipid vacuoles in the cytoplasm of hepatocytes. The findings of our study question the applicability of taurolidine for OS treatment and may suggest the need for caution regarding the widespread clinical use of taurolidine as an antineoplastic agent.

  9. Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model

    Science.gov (United States)

    Tobío, Araceli; Alfonso, Amparo; Madera-Salcedo, Iris; Botana, Luis M.

    2016-01-01

    Yessotoxins (YTXs) are a group of marine toxins produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. They may have medical interest due to their potential role as anti-allergic but also anti-cancer compounds. However, their biological activities remain poorly characterized. Here, we show that the small molecular compound YTX causes a slight but significant reduction of the ability of mast cells to degranulate. Strikingly, further examination revealed that YTX had a marked and selective cytotoxicity for the RBL-2H3 mast cell line inducing apoptosis, while primary bone marrow derived mast cells were highly resistant. In addition, YTX exhibited strong cytotoxicity against the human B-chronic lymphocytic leukaemia cell line MEC1 and the murine melanoma cell line B16F10. To analyse the potential role of YTX as an anti-cancer drug in vivo we used the well-established B16F10 melanoma preclinical mouse model. Our results demonstrate that a few local application of YTX around established tumours dramatically diminished tumour growth in the absence of any significant toxicity as determined by the absence of weight loss and haematological alterations. Our data support that YTX may have a minor role as an anti-allergic drug, but reveals an important potential for its use as an anti-cancer drug. PMID:27973568

  10. Digital collections and exhibits

    CERN Document Server

    Denzer, Juan

    2015-01-01

    Today's libraries are taking advantage of cutting-edge technologies such as flat panel displays using touch, sound, and hands-free motions to design amazing exhibits using everything from simple computer hardware to advanced technologies such as the Microsoft Kinect. Libraries of all types are striving to add new interactive experiences for their patrons through exciting digital exhibits, both online and off. Digital Collections and Exhibits takes away the mystery of designing stunning digital exhibits to spotlight library trea

  11. A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs exhibits similar aggressive phenotype to the human disease

    Directory of Open Access Journals (Sweden)

    Kau Punit

    2012-03-01

    Full Text Available Abstract Background Triple-negative breast cancer (TNBC exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of breast cancer, without tumor-specific treatment options and accounts for 15% of all types of breast cancer with higher percentages in premenopausal African-American and Hispanic women. The reason for this aggressive phenotype is currently the focus of intensive research. However, progress is hampered by the lack of suitable TNBC cell model systems. Methods To understand the mechanistic basis for the aggressiveness of TNBC, we produced a stable TNBC cell line by sorting for 4T1 cells that do not express the estrogen receptor (ER, progesterone receptor (PgR or the gene for human epidermal growth factor receptor 2 (HER2. As a control, we produced a stable triple-positive breast cancer (TPBC cell line by transfecting 4T1 cells with rat HER2, ER and PgR genes and sorted for cells with high expression of ER and PgR by flow cytometry and high expression of the HER2 gene by Western blot analysis. Results We isolated tumor-initiating cells (TICs by sorting for CD24+/CD44high/ALDH1+ cells from TNBC (TNBC-TICs and TPBC (TPBC-TICs stable cell lines. Limiting dilution transplantation experiments revealed that CD24+/CD44high/ALDH1+ cells derived from TNBC (TNBC-TICs and TPBC (TPBC-TICs were significantly more effective at repopulating the mammary glands of naïve female BALB/c mice than CD24-/CD44-/ALDH1- cells. Implantation of the TNBC-TICs resulted in significantly larger tumors, which metastasized to the lungs to a significantly greater extent than TNBC, TPBC-TICs, TPBC or parental 4T1 cells. We further demonstrated that the increased aggressiveness of TNBC-TICs correlates with the presence of high levels of mouse twenty-five kDa heat shock protein (Hsp25/mouse HspB1 and seventy-two kDa heat shock protein (Hsp72/HspA1A. Conclusions

  12. Etruscan Culture Exhibition

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    EARLY this year an exhibition on the ancient civilization of Etruria was held at the Beijing-based China Millennium Monument.The theme of the exhibition was Etruscan Culture and on show were the most representative cultural and historical relics of this ancient civilization unearthed in the past 20 years. The 349 exhibits from various

  13. Ethics on Exhibit

    Science.gov (United States)

    Vick, Randy M.

    2011-01-01

    This article discusses ethical questions raised by an exhibition of work by an artist with a history of mental illness and the exhibition's relevance to art therapy and “outsider art” discourse on the subject. Considerations for how such an exhibit could be handled had the circumstances included an art therapist and art therapy client are…

  14. Muscle spindles exhibit core lesions and extensive degeneration of intrafusal fibers in the Ryr1{sup I4895T/wt} mouse model of core myopathy

    Energy Technology Data Exchange (ETDEWEB)

    Zvaritch, Elena; MacLennan, David H., E-mail: david.maclennan@utoronto.ca

    2015-04-24

    Muscle spindles from the hind limb muscles of adult Ryr1{sup I4895T/wt} (IT/+) mice exhibit severe structural abnormalities. Up to 85% of the spindles are separated from skeletal muscle fascicles by a thick layer of connective tissue. Many intrafusal fibers exhibit degeneration, with Z-line streaming, compaction and collapse of myofibrillar bundles, mitochondrial clumping, nuclear shrinkage and pyknosis. The lesions resemble cores observed in the extrafusal myofibers of this animal model and of core myopathy patients. Spindle abnormalities precede those in extrafusal fibers, indicating that they are a primary pathological feature in this murine Ryr1-related core myopathy. Muscle spindle involvement, if confirmed for human core myopathy patients, would provide an explanation for an array of devastating clinical features characteristic of these diseases and provide novel insights into the pathology of RYR1-related myopathies. - Highlights: • Muscle spindles exhibit structural abnormalities in a mouse model of core myopathy. • Myofibrillar collapse and mitochondrial clumping is observed in intrafusal fibers. • Myofibrillar degeneration follows a pattern similar to core formation in extrafusal myofibers. • Muscle spindle abnormalities are a part of the pathological phenotype in the mouse model of core myopathy. • Direct involvement of muscle spindles in the pathology of human RYR1-related myopathies is proposed.

  15. Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection

    Science.gov (United States)

    Ronca, Shannon E.; Smith, Jeanon; Koma, Takaaki; Miller, Magda M.; Yun, Nadezhda; Dineley, Kelly T.; Paessler, Slobodan

    2017-01-01

    Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic-like syndrome. In the present study, we aimed to adapt an animal model of alphavirus infection survival to study the development of these long-term neurological complications. Upon low-dose infection of wild-type C57B/6 mice, asymptomatic and symptomatic groups were established and compared to mock-infected mice to measure general health and baseline neurological function, including the acoustic startle response and prepulse inhibition paradigm. Prepulse inhibition is a robust operational measure of sensorimotor gating, a fundamental form of information processing. Deficits in prepulse inhibition manifest as the inability to filter out extraneous sensory stimuli. Sensory gating is disrupted in schizophrenia and other mental disorders, as well as neurodegenerative diseases. Symptomatic mice developed deficits in prepulse inhibition that lasted through 6 months post infection; these deficits were absent in asymptomatic or mock-infected groups. Accompanying prepulse inhibition deficits, symptomatic animals exhibited thalamus damage as visualized with H&E staining, as well as increased GFAP expression in the posterior complex of the thalamus and dentate gyrus of the hippocampus. These histological changes and increased GFAP expression were absent in the asymptomatic and mock-infected animals, indicating that glial scarring could have contributed to the prepulse inhibition phenotype observed in the symptomatic animals. This model provides a tool to test mechanisms of and treatments for the neurological sequelae of viral encephalitis and begins to delineate potential explanations for the development of such sequelae post infection.

  16. RESULTS OF INTERBANK EXCHANGE RATES FORECASTING USING STATE SPACE MODEL

    Directory of Open Access Journals (Sweden)

    Muhammad Kashif

    2008-07-01

    Full Text Available This study evaluates the performance of three alternative models for forecasting daily interbank exchange rate of U.S. dollar measured in Pak rupees. The simple ARIMA models and complex models such as GARCH-type models and a state space model are discussed and compared. Four different measures are used to evaluate the forecasting accuracy. The main result is the state space model provides the best performance among all the models.

  17. Muscle spindles exhibit core lesions and extensive degeneration of intrafusal fibers in the Ryr1(I4895T/wt) mouse model of core myopathy.

    Science.gov (United States)

    Zvaritch, Elena; MacLennan, David H

    2015-04-24

    Muscle spindles from the hind limb muscles of adult Ryr1(I4895T/wt) (IT/+) mice exhibit severe structural abnormalities. Up to 85% of the spindles are separated from skeletal muscle fascicles by a thick layer of connective tissue. Many intrafusal fibers exhibit degeneration, with Z-line streaming, compaction and collapse of myofibrillar bundles, mitochondrial clumping, nuclear shrinkage and pyknosis. The lesions resemble cores observed in the extrafusal myofibers of this animal model and of core myopathy patients. Spindle abnormalities precede those in extrafusal fibers, indicating that they are a primary pathological feature in this murine Ryr1-related core myopathy. Muscle spindle involvement, if confirmed for human core myopathy patients, would provide an explanation for an array of devastating clinical features characteristic of these diseases and provide novel insights into the pathology of RYR1-related myopathies.

  18. Exhibiting Mozart: Rethinking Biography

    OpenAIRE

    Spring, Ulrike

    2010-01-01

    Abstract: The article analyses the new permanent exhibition in the composer Wolfgang A. Mozart’s apartment in Vienna, opened in 2006, from the curator’s perspective. The exhibition presents an approach to biographical display in which the exhibited person becomes part of a multifaceted web of contexts, and the article argues for the active deployment of the polysemic character of objects as a means of grasping the complexity of a person’s biography. Presenting a concept for the...

  19. Some results regarding the comparison of the Earth's atmospheric models

    Directory of Open Access Journals (Sweden)

    Šegan S.

    2005-01-01

    Full Text Available In this paper we examine air densities derived from our realization of aeronomic atmosphere models based on accelerometer measurements from satellites in a low Earth's orbit (LEO. Using the adapted algorithms we derive comparison parameters. The first results concerning the adjustment of the aeronomic models to the total-density model are given.

  20. Test Control Center exhibit

    Science.gov (United States)

    2000-01-01

    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  1. The Effect of Bathymetric Filtering on Nearshore Process Model Results

    Science.gov (United States)

    2009-01-01

    Filtering on Nearshore Process Model Results 6. AUTHOR(S) Nathaniel Plant, Kacey L. Edwards, James M. Kaihatu, Jayaram Veeramony, Yuan-Huang L. Hsu...filtering on nearshore process model results Nathaniel G. Plant **, Kacey L Edwardsb, James M. Kaihatuc, Jayaram Veeramony b, Larry Hsu’’, K. Todd Holland...assimilation efforts that require this information. Published by Elsevier B.V. 1. Introduction Nearshore process models are capable of predicting

  2. Steel Containment Vessel Model Test: Results and Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Costello, J.F.; Hashimote, T.; Hessheimer, M.F.; Luk, V.K.

    1999-03-01

    A high pressure test of the steel containment vessel (SCV) model was conducted on December 11-12, 1996 at Sandia National Laboratories, Albuquerque, NM, USA. The test model is a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of an improved Mark II boiling water reactor (BWR) containment. A concentric steel contact structure (CS), installed over the SCV model and separated at a nominally uniform distance from it, provided a simplified representation of a reactor shield building in the actual plant. The SCV model and contact structure were instrumented with strain gages and displacement transducers to record the deformation behavior of the SCV model during the high pressure test. This paper summarizes the conduct and the results of the high pressure test and discusses the posttest metallurgical evaluation results on specimens removed from the SCV model.

  3. EXHIBITION: Accelerated Particles

    CERN Multimedia

    2004-01-01

    An exhibition of plastic arts and two evenings of performances by sound and visual artists as part of CERN's 50th anniversary celebrations. Fifty candles for CERN, an international laboratory renowned for fundamental research, is a cause for celebration. Since March this year, Geneva and neighbouring parts of France have been the venues for a wealth of small and large-scale events, which will continue until November. Given CERN's location in the commune of Meyrin, the ForuMeyrin is hosting exhibitions of plastic arts and performances entitled: Accelerated Particles. Several works will be exhibited and performed in two 'salons'. Salon des matières: An exhibition of plastic arts From Tues 12 October to Wed 3 November 2004 Tuesdays to Fridays: 16:00 to 19:00 Saturdays: 14:00 to 18:00 Exhibition open late on performance nights, entrance free Salon des particules: Musical and visual performances Tues 12 and Mon 25 October from 20:00 to 23:00 Preview evening for both events: Tues 12 October from 18:...

  4. Council Chamber exhibition

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    To complete the revamp of CERN’s Council Chamber, a new exhibition is being installed just in time for the June Council meetings.   Panels will showcase highlights of CERN’s history, using some of the content prepared for the exhibitions marking 50 years of the PS, which were displayed in the main building last November. The previous photo exhibition in the Council Chamber stopped at the 1970s. To avoid the new panels becoming quickly out of date, photos are grouped together around specific infrastructures, rather than following a classic time-line. “We have put the focus on the accelerators – the world-class facilities that CERN has been offering researchers over the years, from the well-known large colliders to the lesser-known smaller facilities,” says Emma Sanders, who worked on the content. The new exhibition will be featured in a future issue of the Bulletin with photos and an interview with Fabienne Marcastel, designer of the exhibit...

  5. Results from a new Cocks-Ashby style porosity model

    Science.gov (United States)

    Barton, Nathan

    2017-01-01

    A new porosity evolution model is described, along with preliminary results. The formulation makes use of a Cocks-Ashby style treatment of porosity kinetics that includes rate dependent flow in the mechanics of porosity growth. The porosity model is implemented in a framework that allows for a variety of strength models to be used for the matrix material, including ones with significant changes in rate sensitivity as a function of strain rate. Results of the effect of changing strain rate sensitivity on porosity evolution are shown. The overall constitutive model update involves the coupled solution of a system of nonlinear equations.

  6. Results of the Marine Ice Sheet Model Intercomparison Project, MISMIP

    Directory of Open Access Journals (Sweden)

    F. Pattyn

    2012-05-01

    Full Text Available Predictions of marine ice-sheet behaviour require models that are able to robustly simulate grounding line migration. We present results of an intercomparison exercise for marine ice-sheet models. Verification is effected by comparison with approximate analytical solutions for flux across the grounding line using simplified geometrical configurations (no lateral variations, no effects of lateral buttressing. Unique steady state grounding line positions exist for ice sheets on a downward sloping bed, while hysteresis occurs across an overdeepened bed, and stable steady state grounding line positions only occur on the downward-sloping sections. Models based on the shallow ice approximation, which does not resolve extensional stresses, do not reproduce the approximate analytical results unless appropriate parameterizations for ice flux are imposed at the grounding line. For extensional-stress resolving "shelfy stream" models, differences between model results were mainly due to the choice of spatial discretization. Moving grid methods were found to be the most accurate at capturing grounding line evolution, since they track the grounding line explicitly. Adaptive mesh refinement can further improve accuracy, including fixed grid models that generally perform poorly at coarse resolution. Fixed grid models, with nested grid representations of the grounding line, are able to generate accurate steady state positions, but can be inaccurate over transients. Only one full-Stokes model was included in the intercomparison, and consequently the accuracy of shelfy stream models as approximations of full-Stokes models remains to be determined in detail, especially during transients.

  7. The Animal Model Determines the Results of Aeromonas Virulence Factors

    Science.gov (United States)

    Romero, Alejandro; Saraceni, Paolo R.; Merino, Susana; Figueras, Antonio; Tomás, Juan M.; Novoa, Beatriz

    2016-01-01

    The selection of an experimental animal model is of great importance in the study of bacterial virulence factors. Here, a bath infection of zebrafish larvae is proposed as an alternative model to study the virulence factors of Aeromonas hydrophila. Intraperitoneal infections in mice and trout were compared with bath infections in zebrafish larvae using specific mutants. The great advantage of this model is that bath immersion mimics the natural route of infection, and injury to the tail also provides a natural portal of entry for the bacteria. The implication of T3SS in the virulence of A. hydrophila was analyzed using the AH-1::aopB mutant. This mutant was less virulent than the wild-type strain when inoculated into zebrafish larvae, as described in other vertebrates. However, the zebrafish model exhibited slight differences in mortality kinetics only observed using invertebrate models. Infections using the mutant AH-1ΔvapA lacking the gene coding for the surface S-layer suggested that this protein was not totally necessary to the bacteria once it was inside the host, but it contributed to the inflammatory response. Only when healthy zebrafish larvae were infected did the mutant produce less mortality than the wild-type. Variations between models were evidenced using the AH-1ΔrmlB, which lacks the O-antigen lipopolysaccharide (LPS), and the AH-1ΔwahD, which lacks the O-antigen LPS and part of the LPS outer-core. Both mutants showed decreased mortality in all of the animal models, but the differences between them were only observed in injured zebrafish larvae, suggesting that residues from the LPS outer core must be important for virulence. The greatest differences were observed using the AH-1ΔFlaB-J (lacking polar flagella and unable to swim) and the AH-1::motX (non-motile but producing flagella). They were as pathogenic as the wild-type strain when injected into mice and trout, but no mortalities were registered in zebrafish larvae. This study demonstrates

  8. Updated Results for the Wake Vortex Inverse Model

    Science.gov (United States)

    Robins, Robert E.; Lai, David Y.; Delisi, Donald P.; Mellman, George R.

    2008-01-01

    NorthWest Research Associates (NWRA) has developed an Inverse Model for inverting aircraft wake vortex data. The objective of the inverse modeling is to obtain estimates of the vortex circulation decay and crosswind vertical profiles, using time history measurements of the lateral and vertical position of aircraft vortices. The Inverse Model performs iterative forward model runs using estimates of vortex parameters, vertical crosswind profiles, and vortex circulation as a function of wake age. Iterations are performed until a user-defined criterion is satisfied. Outputs from an Inverse Model run are the best estimates of the time history of the vortex circulation derived from the observed data, the vertical crosswind profile, and several vortex parameters. The forward model, named SHRAPA, used in this inverse modeling is a modified version of the Shear-APA model, and it is described in Section 2 of this document. Details of the Inverse Model are presented in Section 3. The Inverse Model was applied to lidar-observed vortex data at three airports: FAA acquired data from San Francisco International Airport (SFO) and Denver International Airport (DEN), and NASA acquired data from Memphis International Airport (MEM). The results are compared with observed data. This Inverse Model validation is documented in Section 4. A summary is given in Section 5. A user's guide for the inverse wake vortex model is presented in a separate NorthWest Research Associates technical report (Lai and Delisi, 2007a).

  9. Exhibition in Sight

    Science.gov (United States)

    Wasserman, Burton

    1978-01-01

    Ludwig Mies van der Rohe is known primarily as an architect. However, he also designed chairs and tables. Discusses an exhibit held in New York City a few months ago which showed how well the famous architect achieved his goals in the area of furniture design. (Author/RK)

  10. Exhibitions in Sight

    Science.gov (United States)

    Wasserman, Burton

    1977-01-01

    Today, few artists make serving vessels on a monumental scale. Here artists compete in this unique area of specialization prompted by the Campbell Museum in Camden, New Jersey, which is dedicated to collecting and exhibiting the very best in soup tureens. (Author/RK)

  11. EXHIBITION: Accelerated Particles

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ An exhibition of plastic arts and two evenings of performances by sound and visual artists as part of CERN's fiftieth anniversary celebrations. The fiftieth anniversary of a world famous organization like CERN, an international laboratory specializing in fundamental research, is a cause for celebration. Since March this year, Geneva and neighbouring parts of France have been the venues for a wealth of small and large-scale events, which will continue until November. Given CERN's location in the commune of Meyrin, the ForuMeyrin is hosting two "salons" consisting of an exhibition of plastic arts and evenings of music and visual arts performances with the collective title of "Accelerated Particles". Several works will be exhibited and performed. Salon des matières: An exhibition of plastic arts Until Wednesday 3 November 2004. Tuesdays to Fridays: 4.00 p.m. to 7.00 p.m. Saturdays: 2.00 p.m. to 6.00 p.m. Doors open late on the evening of the performances. Salon des ...

  12. Towards more accurate isoscapes encouraging results from wine, water and marijuana data/model and model/model comparisons.

    Science.gov (United States)

    West, J. B.; Ehleringer, J. R.; Cerling, T.

    2006-12-01

    Understanding how the biosphere responds to change it at the heart of biogeochemistry, ecology, and other Earth sciences. The dramatic increase in human population and technological capacity over the past 200 years or so has resulted in numerous, simultaneous changes to biosphere structure and function. This, then, has lead to increased urgency in the scientific community to try to understand how systems have already responded to these changes, and how they might do so in the future. Since all biospheric processes exhibit some patchiness or patterns over space, as well as time, we believe that understanding the dynamic interactions between natural systems and human technological manipulations can be improved if these systems are studied in an explicitly spatial context. We present here results of some of our efforts to model the spatial variation in the stable isotope ratios (δ2H and δ18O) of plants over large spatial extents, and how these spatial model predictions compare to spatially explicit data. Stable isotopes trace and record ecological processes and as such, if modeled correctly over Earth's surface allow us insights into changes in biosphere states and processes across spatial scales. The data-model comparisons show good agreement, in spite of the remaining uncertainties (e.g., plant source water isotopic composition). For example, inter-annual changes in climate are recorded in wine stable isotope ratios. Also, a much simpler model of leaf water enrichment driven with spatially continuous global rasters of precipitation and climate normals largely agrees with complex GCM modeling that includes leaf water δ18O. Our results suggest that modeling plant stable isotope ratios across large spatial extents may be done with reasonable accuracy, including over time. These spatial maps, or isoscapes, can now be utilized to help understand spatially distributed data, as well as to help guide future studies designed to understand ecological change across

  13. Generalised Chou-Yang model and recent results

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem [International Centre for Theoretical Physics, Trieste (Italy); Rashid, H. [Punjab Univ., Lahore (Pakistan). Centre for High Energy Physics

    1996-12-31

    It is shown that most recent results of E710 and UA4/2 collaboration for the total cross section and {rho} together with earlier measurements give good agreement with measurements for the differential cross section at 546 and 1800 GeV within the framework of Generalised Chou-Yang model. These results are also compared with the predictions of other models. (author) 16 refs.

  14. Life cycle Prognostic Model Development and Initial Application Results

    Energy Technology Data Exchange (ETDEWEB)

    Jeffries, Brien; Hines, Wesley; Nam, Alan; Sharp, Michael; Upadhyaya, Belle [The University of Tennessee, Knoxville (United States)

    2014-08-15

    In order to obtain more accurate Remaining Useful Life (RUL) estimates based on empirical modeling, a Lifecycle Prognostics algorithm was developed that integrates various prognostic models. These models can be categorized into three types based on the type of data they process. The application of multiple models takes advantage of the most useful information available as the system or component operates through its lifecycle. The Lifecycle Prognostics is applied to an impeller test bed, and the initial results serve as a proof of concept.

  15. Conceptual Incoherence as a Result of the use of Multiple Historical Models in School Textbooks

    Science.gov (United States)

    Gericke, Niklas M.; Hagberg, Mariana

    2010-08-01

    This paper explores the occurrence of conceptual incoherence in upper secondary school textbooks resulting from the use of multiple historical models. Swedish biology and chemistry textbooks, as well as a selection of books from English speaking countries, were examined. The purpose of the study was to identify which models are used to represent the phenomenon of gene function in textbooks and to investigate how these models relate to historical scientific models and subject matter contexts. Models constructed for specific use in textbooks were identified using concept mapping. The data were further analyzed by content analysis. The study shows that several different historical models are used in parallel in textbooks to describe gene function. Certain historical models were used more often then others and the most recent scientific views were rarely referred to in the textbooks. Hybrid models were used frequently, i.e. most of the models in the textbooks consisted of a number of components of several historical models. Since the various historical models were developed as part of different scientific frameworks, hybrid models exhibit conceptual incoherence, which may be a source of confusion for students. Furthermore, the use of different historical models was linked to particular subject contexts in the textbooks studied. The results from Swedish and international textbooks were similar, indicating the general applicability of our conclusions.

  16. CERN permanent exhibitions

    CERN Multimedia

    2016-01-01

    Explore by yourself the issues CERN's physicists are trying to solve: given that the entire universe is made of particles, where do they come from? Why do they behave in the way they do? Discover the massive apparatus used by physicists at CERN, like the LHC, and see how each part works. And if you have more time on site, follow the LHC circuit at ground level to understand in situ this giant machine. Enter our exhibitions. Welcome!

  17. Upcycling CERN Exhibitions

    CERN Multimedia

    Katarina Anthony

    2015-01-01

    Summer is coming - and with it, a new Microcosm exhibition showcasing CERN (see here). But while the new exhibit is preparing to enchant visitors, many have been asking about the site's former content. Will it simply be out with the old and in with the new? Not as such!   The plasma ball from Microcosm is now on display at the LHCb site. As Microcosm's new content is moving in, its old content is moving up. From LHCb to IdeaSquare, former Microcosm displays and objects are being installed across the CERN site. "Microcosm featured many elements that were well suited to life outside of the exhibition," says Emma Sanders, Microcosm project leader in the EDU group. "We didn't want this popular content to go to waste, and so set out to find them new homes across CERN." The LHCb experiment has received a number of Microcosm favourites, including the Rutherford experiment, the cosmic ray display and the Thomson experiment. "We&...

  18. 会展管理专业培养模式探索%An Inquiry into the Cultivation Model of Exhibition Management Major

    Institute of Scientific and Technical Information of China (English)

    张乐

    2011-01-01

    China's exhibition industry is now in its rapid development period,but it is in a serious shortage of talent supply.Exhibition teaching is in its exploration period,how to accurately position the personnel and to set a reasonable course system is a crucial problem to be solved.Faith to the guiding ideology of "based on practical situation,business-oriented,school-enterprise cooperation,practical leadership," this paper hopes to form a set of new cultivation model that is able to cultivate hightech applied talents able to meet the needs of the society and realize the cohesion of actual situation with enterprises.%我国会展业目前正处在飞速发展时期,而会展人才的供应却严重匮乏。会展专业教学正处于探索期,如何准确地进行人才定位,设置合理的课程体系,培养出会展企业可以"拿来就用"的人才,是目前会展教育亟待解决的问题。秉着"立足实际、面向企业、校企共建、实用领先"的指导思想,希望通过探索,在课程体系设置、实训基地建设、师资队伍建设、毕业生就业引导等方面,形成一套能够培养出符合社会需求的、能实现与企业零距离对接的高技能应用型人才的会展专业培养新模式。

  19. The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H mouse model exhibits accelerated human VCP-associated disease pathology.

    Directory of Open Access Journals (Sweden)

    Angèle Nalbandian

    Full Text Available Valosin containing protein (VCP mutations are the cause of hereditary inclusion body myopathy, Paget's disease of bone, frontotemporal dementia (IBMPFD. VCP gene mutations have also been linked to 2% of isolated familial amyotrophic lateral sclerosis (ALS. VCP is at the intersection of disrupted ubiquitin proteasome and autophagy pathways, mechanisms responsible for the intracellular protein degradation and abnormal pathology seen in muscle, brain and spinal cord. We have developed the homozygous knock-in VCP mouse (VCP(R155H/R155H model carrying the common R155H mutations, which develops many clinical features typical of the VCP-associated human diseases. Homozygote VCP(R155H/R155H mice typically survive less than 21 days, exhibit weakness and myopathic changes on EMG. MicroCT imaging of the bones reveal non-symmetrical radiolucencies of the proximal tibiae and bone, highly suggestive of PDB. The VCP(R155H/R155H mice manifest prominent muscle, heart, brain and spinal cord pathology, including striking mitochondrial abnormalities, in addition to disrupted autophagy and ubiquitin pathologies. The VCP(R155H/R155H homozygous mouse thus represents an accelerated model of VCP disease and can be utilized to elucidate the intricate molecular mechanisms involved in the pathogenesis of VCP-associated neurodegenerative diseases and for the development of novel therapeutic strategies.

  20. Meteorological Uncertainty of atmospheric Dispersion model results (MUD)

    DEFF Research Database (Denmark)

    Havskov Sørensen, Jens; Amstrup, Bjarne; Feddersen, Henrik

    The MUD project addresses assessment of uncertainties of atmospheric dispersion model predictions, as well as optimum presentation to decision makers. Previously, it has not been possible to estimate such uncertainties quantitatively, but merely to calculate the 'most likely' dispersion scenario...... of the meteorological model results. These uncertainties stem from e.g. limits in meteorological obser-vations used to initialise meteorological forecast series. By perturbing the initial state of an NWP model run in agreement with the available observa-tional data, an ensemble of meteorological forecasts is produced....... However, recent developments in numerical weather prediction (NWP) include probabilistic forecasting techniques, which can be utilised also for atmospheric dispersion models. The ensemble statistical methods developed and applied to NWP models aim at describing the inherent uncertainties...

  1. Meteorological Uncertainty of atmospheric Dispersion model results (MUD)

    DEFF Research Database (Denmark)

    Havskov Sørensen, Jens; Amstrup, Bjarne; Feddersen, Henrik

    The MUD project addresses assessment of uncertainties of atmospheric dispersion model predictions, as well as possibilities for optimum presentation to decision makers. Previously, it has not been possible to estimate such uncertainties quantitatively, but merely to calculate the ‘most likely...... uncertainties of the meteorological model results. These uncertainties stem from e.g. limits in meteorological observations used to initialise meteorological forecast series. By perturbing e.g. the initial state of an NWP model run in agreement with the available observational data, an ensemble......’ dispersion scenario. However, recent developments in numerical weather prediction (NWP) include probabilistic forecasting techniques, which can be utilised also for long-range atmospheric dispersion models. The ensemble statistical methods developed and applied to NWP models aim at describing the inherent...

  2. Mathematical Existence Results for the Doi-Edwards Polymer Model

    Science.gov (United States)

    Chupin, Laurent

    2017-01-01

    In this paper, we present some mathematical results on the Doi-Edwards model describing the dynamics of flexible polymers in melts and concentrated solutions. This model, developed in the late 1970s, has been used and extensively tested in modeling and simulation of polymer flows. From a mathematical point of view, the Doi-Edwards model consists in a strong coupling between the Navier-Stokes equations and a highly nonlinear constitutive law. The aim of this article is to provide a rigorous proof of the well-posedness of the Doi-Edwards model, namely that it has a unique regular solution. We also prove, which is generally much more difficult for flows of viscoelastic type, that the solution is global in time in the two dimensional case, without any restriction on the smallness of the data.

  3. Modeling Results for the ITER Cryogenic Fore Pump

    Science.gov (United States)

    Zhang, Dongsheng

    The work presented here is the analysis and modeling of the ITER-Cryogenic Fore Pump (CFP), also called Cryogenic Viscous Compressor (CVC). Unlike common cryopumps that are usually used to create and maintain vacuum, the cryogenic fore pump is designed for ITER to collect and compress hydrogen isotopes during the regeneration process of the torus cryopumps. Different from common cryopumps, the ITER-CFP works in the viscous flow regime. As a result, both adsorption boundary conditions and transport phenomena contribute unique features to the pump performance. In this report, the physical mechanisms of cryopumping are studied, especially the diffusion-adsorption process and these are coupled with the standard equations of species, momentum and energy balance, as well as the equation of state. Numerical models are developed, which include highly coupled non-linear conservation equations of species, momentum, and energy and equation of state. Thermal and kinetic properties are treated as functions of temperature, pressure, and composition of the gas fluid mixture. To solve such a set of equations, a novel numerical technique, identified as the Group-Member numerical technique is proposed. This document presents three numerical models: a transient model, a steady state model, and a hemisphere (or molecular flow) model. The first two models are developed based on analysis of the raw experimental data while the third model is developed as a preliminary study. The modeling results are compared with available experiment data for verification. The models can be used for cryopump design, and can also benefit problems, such as loss of vacuum in a cryomodule or cryogenic desublimation. The scientific and engineering investigation being done here builds connections between Mechanical Engineering and other disciplines, such as Chemical Engineering, Physics, and Chemistry.

  4. Comparison of NASCAP modelling results with lumped circuit analysis

    Science.gov (United States)

    Stang, D. B.; Purvis, C. K.

    1980-01-01

    Engineering design tools that can be used to predict the development of absolute and differential potentials by realistic spacecraft under geomagnetic substorm conditions are described. Two types of analyses are in use: (1) the NASCAP code, which computes quasistatic charging of geometrically complex objects with multiple surface materials in three dimensions; (2) lumped element equivalent circuit models that are used for analyses of particular spacecraft. The equivalent circuit models require very little computation time, however, they cannot account for effects, such as the formation of potential barriers, that are inherently multidimensional. Steady state potentials of structure and insulation are compared with those resulting from the equivalent circuit model.

  5. The East model: recent results and new progresses

    CERN Document Server

    Faggionato, Alessandra; Roberto, Cyril; Toninelli, Cristina

    2012-01-01

    The East model is a particular one dimensional interacting particle system in which certain transitions are forbidden according to some constraints depending on the configuration of the system. As such it has received particular attention in the physics literature as a special case of a more general class of systems referred to as kinetically constrained models, which play a key role in explaining some features of the dynamics of glasses. In this paper we give an extensive overview of recent rigorous results concerning the equilibrium and non-equilibrium dynamics of the East model together with some new improvements.

  6. Constraining hybrid inflation models with WMAP three-year results

    CERN Document Server

    Cardoso, A

    2006-01-01

    We reconsider the original model of quadratic hybrid inflation in light of the WMAP three-year results and study the possibility of obtaining a spectral index of primordial density perturbations, $n_s$, smaller than one from this model. The original hybrid inflation model naturally predicts $n_s\\geq1$ in the false vacuum dominated regime but it is also possible to have $n_s<1$ when the quadratic term dominates. We therefore investigate whether there is also an intermediate regime compatible with the latest constraints, where the scalar field value during the last 50 e-folds of inflation is less than the Planck scale.

  7. Recent MEG Results and Predictive SO(10) Models

    CERN Document Server

    Fukuyama, Takeshi

    2011-01-01

    Recent MEG results of a search for the lepton flavor violating (LFV) muon decay, $\\mu \\to e \\gamma$, show 3 events as the best value for the number of signals in the maximally likelihood fit. Although this result is still far from the evidence/discovery in statistical point of view, it might be a sign of a certain new physics beyond the Standard Model. As has been well-known, supersymmetric (SUSY) models can generate the $\\mu \\to e \\gamma$ decay rate within the search reach of the MEG experiment. A certain class of SUSY grand unified theory (GUT) models such as the minimal SUSY SO(10) model (we call this class of models "predictive SO(10) models") can unambiguously determine fermion Yukawa coupling matrices, in particular, the neutrino Dirac Yukawa matrix. Based on the universal boundary conditions for soft SUSY breaking parameters at the GUT scale, we calculate the rate of the $\\mu \\to e \\gamma$ process by using the completely determined Dirac Yukawa matrix in two examples of predictive SO(10) models. If we ...

  8. Space Shuttle Cockpit exhibit

    Science.gov (United States)

    2000-01-01

    Want to sit in the cockpit of the Space Shuttle and watch astronauts work in outer space? At StenniSphere, you can do that and much more. StenniSphere, the visitor center at John C. Stennis Space Center in Hancock County, Miss., presents 14,000-square-feet of interactive exhibits that depict America's race for space as well as a glimpse of the future. StenniSphere is open free of charge from 9 a.m. to 5 p.m. daily.

  9. Summary of FY15 results of benchmark modeling activities

    Energy Technology Data Exchange (ETDEWEB)

    Arguello, J. Guadalupe [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    Sandia is participating in the third phase of an is a contributing partner to a U.S.-German "Joint Project" entitled "Comparison of current constitutive models and simulation procedures on the basis of model calculations of the thermo-mechanical behavior and healing of rock salt." The first goal of the project is to check the ability of numerical modeling tools to correctly describe the relevant deformation phenomena in rock salt under various influences. Achieving this goal will lead to increased confidence in the results of numerical simulations related to the secure storage of radioactive wastes in rock salt, thereby enhancing the acceptance of the results. These results may ultimately be used to make various assertions regarding both the stability analysis of an underground repository in salt, during the operating phase, and the long-term integrity of the geological barrier against the release of harmful substances into the biosphere, in the post-operating phase.

  10. Standard Model physics results from ATLAS and CMS

    CERN Document Server

    Dordevic, Milos

    2015-01-01

    The most recent results of Standard Model physics studies in proton-proton collisions at 7 TeV and 8 TeV center-of-mass energy based on data recorded by ATLAS and CMS detectors during the LHC Run I are reviewed. This overview includes studies of vector boson production cross section and properties, results on V+jets production with light and heavy flavours, latest VBS and VBF results, measurement of diboson production with an emphasis on ATGC and QTGC searches, as well as results on inclusive jet cross sections with strong coupling constant measurement and PDF constraints. The outlined results are compared to the prediction of the Standard Model.

  11. The Optimization Model of the Supply Chain Structure of Exhibition%会展供应链结构优化模型构建与系统优化

    Institute of Scientific and Technical Information of China (English)

    申强; 杨为民; 刘笑冰

    2014-01-01

    Considering the rapid development of the convention and exhibition industry in China and characteristics of supply chain management,this paper defines supply chain of the convention and exhibition industry based on principles of manufacturing supply chain and service supply chain management,combining with characteristics of the convention and exhibition industry.Morever,it constructs the optimization model of the supply chain structure and proposes the optimization concrete content and measures for the optimization model.The result shows that the supply chain of exhibition integrates the content and the characteristics of the manufacturing and service supply chain,and the key to improve its performance is optimizing the structure of its organization,implementation of information sharing and restriction of the behaviors of the participates.%考虑到中国会展产业的迅速发展和供应链管理特点,本文基于制造供应链和服务供应链管理理论,结合会展产业自身特征,在对会展供应链进行定义的基础上,构建会展供应链结构优化模型,并针对该优化模型提出具体的优化内容和措施。研究表明,会展供应链融合了制造供应链和服务供应链的特性和内容,其绩效提高的关键在于优化自身组织结构、实现参与主体的信息共享并约束参与主体的行为。

  12. Relationship Marketing results: proposition of a cognitive mapping model

    Directory of Open Access Journals (Sweden)

    Iná Futino Barreto

    2015-12-01

    Full Text Available Objective - This research sought to develop a cognitive model that expresses how marketing professionals understand the relationship between the constructs that define relationship marketing (RM. It also tried to understand, using the obtained model, how objectives in this field are achieved. Design/methodology/approach – Through cognitive mapping, we traced 35 individual mental maps, highlighting how each respondent understands the interactions between RM elements. Based on the views of these individuals, we established an aggregate mental map. Theoretical foundation – The topic is based on a literature review that explores the RM concept and its main elements. Based on this review, we listed eleven main constructs. Findings – We established an aggregate mental map that represents the RM structural model. Model analysis identified that CLV is understood as the final result of RM. We also observed that the impact of most of the RM elements on CLV is brokered by loyalty. Personalization and quality, on the other hand, proved to be process input elements, and are the ones that most strongly impact others. Finally, we highlight that elements that punish customers are much less effective than elements that benefit them. Contributions - The model was able to insert core elements of RM, but absent from most formal models: CLV and customization. The analysis allowed us to understand the interactions between the RM elements and how the end result of RM (CLV is formed. This understanding improves knowledge on the subject and helps guide, assess and correct actions.

  13. Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.

    Science.gov (United States)

    Shimohata, Atsushi; Ishihara, Keiichi; Hattori, Satoko; Miyamoto, Hiroyuki; Morishita, Hiromasa; Ornthanalai, Guy; Raveau, Matthieu; Ebrahim, Abdul Shukkur; Amano, Kenji; Yamada, Kazuyuki; Sago, Haruhiko; Akiba, Satoshi; Mataga, Nobuko; Murphy, Niall P; Miyakawa, Tsuyoshi; Yamakawa, Kazuhiro

    2017-07-01

    Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice. Ts1Cje mice showed enhanced locomotor activity in novel environments and increased social contact with unfamiliar partners when compared with wild-type littermates, but a significantly lower activity in familiar environments. Ts1Cje mice also exhibited some signs of decreased depression like-behavior. Furthermore, Ts1Cje mice showed monoamine abnormalities, including increased extracellular dopamine and serotonin, and enhanced catabolism in the striatum and ventral forebrain. This study constitutes the first report of deviated monoamine metabolism that may help explain the basis for abnormal behaviors, including the environmental stimuli-triggered hyperactivity, increased sociability and decreased depression-like behavior in Ts1Cje mice. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Anniversary Exhibition. Nechvolodov.

    Directory of Open Access Journals (Sweden)

    - -

    2006-03-01

    Full Text Available On the 10th of August, 2005 in Tartu (the second biggest educational and cultural city in Estonia Stanislav Nechvolodov's exhibition was opened to show the 5-year cycle of his work, traditional for the author and his admirers. At the opening ceremony Nechvolodov said that the exhibition was the last one and appointed on his 70th anniversary.The architectural and building society in Irkutsk remembers Stanislav Nechvolodov as an architect working on dwelling and civil buildings in 1960-70s. Below are some extracts from the Estonian press.«Postimees» newspaper, December 1993. The interview «Expressionistic naturalist, conservative Nechvolodov» by journalist Eric Linnumyagi. He asks about all the details and describes the troubles experienced by Nechvolodov during the perestroika period in Estonia, for example: the Tartu University refused to install the sculpture of Socrat, the art school refused to engage him as an instructor, the sculpture of Socrat moved to Vrotzlav, Poland, and Nechvolodov moved to Poland to read lectures there.«Tartu» newspaper, November 2000. Mats Oun, artist, says in the article «Nechvolodov: a man of Renaissance»: «Nechvolodov works in Estonia, his works are placed in many local and foreign museums. Regardless some insignificant faults, he deserves a high estimation, and his manysided open exhibition can be an example for other artists. He is a man of Renaissance».

  15. Value of the distant future: Model-independent results

    Science.gov (United States)

    Katz, Yuri A.

    2017-01-01

    This paper shows that the model-independent account of correlations in an interest rate process or a log-consumption growth process leads to declining long-term tails of discount curves. Under the assumption of an exponentially decaying memory in fluctuations of risk-free real interest rates, I derive the analytical expression for an apt value of the long run discount factor and provide a detailed comparison of the obtained result with the outcome of the benchmark risk-free interest rate models. Utilizing the standard consumption-based model with an isoelastic power utility of the representative economic agent, I derive the non-Markovian generalization of the Ramsey discounting formula. Obtained analytical results allowing simple calibration, may augment the rigorous cost-benefit and regulatory impact analysis of long-term environmental and infrastructure projects.

  16. Marginal production in the Gulf of Mexico - II. Model results

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, Mark J.; Yu, Yunke [Center for Energy Studies, Louisiana State University, Baton Rouge, LA 70803 (United States)

    2010-08-15

    In the second part of this two-part article on marginal production in the Gulf of Mexico, we estimate the number of committed assets in water depth less than 1000 ft that are expected to be marginal over a 60-year time horizon. We compute the expected quantity and value of the production and gross revenue streams of the gulf's committed asset inventory circa. January 2007 using a probabilistic model framework. Cumulative hydrocarbon production from the producing inventory is estimated to be 1056 MMbbl oil and 13.3 Tcf gas. Marginal production from the committed asset inventory is expected to contribute 4.1% of total oil production and 5.4% of gas production. A meta-evaluation procedure is adapted to present the results of sensitivity analysis. Model results are discussed along with a description of the model framework and limitations of the analysis. (author)

  17. Exact results for car accidents in a traffic model

    Science.gov (United States)

    Huang, Ding-wei

    1998-07-01

    Within the framework of a recent model for car accidents on single-lane highway traffic, we study analytically the probability of the occurrence of car accidents. Exact results are obtained. Various scaling behaviours are observed. The linear dependence of the occurrence of car accidents on density is understood as the dominance of a single velocity in the distribution.

  18. Modeling Results For the ITER Cryogenic Fore Pump. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Pfotenhauer, John M. [University of Wisconsin, Madison, WI (United States); Zhang, Dongsheng [University of Wisconsin, Madison, WI (United States)

    2014-03-31

    A numerical model characterizing the operation of a cryogenic fore-pump (CFP) for ITER has been developed at the University of Wisconsin – Madison during the period from March 15, 2011 through June 30, 2014. The purpose of the ITER-CFP is to separate hydrogen isotopes from helium gas, both making up the exhaust components from the ITER reactor. The model explicitly determines the amount of hydrogen that is captured by the supercritical-helium-cooled pump as a function of the inlet temperature of the supercritical helium, its flow rate, and the inlet conditions of the hydrogen gas flow. Furthermore the model computes the location and amount of hydrogen captured in the pump as a function of time. Throughout the model’s development, and as a calibration check for its results, it has been extensively compared with the measurements of a CFP prototype tested at Oak Ridge National Lab. The results of the model demonstrate that the quantity of captured hydrogen is very sensitive to the inlet temperature of the helium coolant on the outside of the cryopump. Furthermore, the model can be utilized to refine those tests, and suggests methods that could be incorporated in the testing to enhance the usefulness of the measured data.

  19. Assessment of Galileo modal test results for mathematical model verification

    Science.gov (United States)

    Trubert, M.

    1984-01-01

    The modal test program for the Galileo Spacecraft was completed at the Jet Propulsion Laboratory in the summer of 1983. The multiple sine dwell method was used for the baseline test. The Galileo Spacecraft is a rather complex 2433 kg structure made of a central core on which seven major appendages representing 30 percent of the total mass are attached, resulting in a high modal density structure. The test revealed a strong nonlinearity in several major modes. This nonlinearity discovered in the course of the test necessitated running additional tests at the unusually high response levels of up to about 21 g. The high levels of response were required to obtain a model verification valid at the level of loads for which the spacecraft was designed. Because of the high modal density and the nonlinearity, correlation between the dynamic mathematical model and the test results becomes a difficult task. Significant changes in the pre-test analytical model are necessary to establish confidence in the upgraded analytical model used for the final load verification. This verification, using a test verified model, is required by NASA to fly the Galileo Spacecraft on the Shuttle/Centaur launch vehicle in 1986.

  20. VNU Exhibitions Asia: Two factors are crucial

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Reporter: How to appraises the Chinese exhibition industry market? Jime Essink :The Chinese exhibition market will experience a fast growth in the coming years. This will mainly be the result of an increase of international visitors who

  1. Modeling vertical loads in pools resulting from fluid injection. [BWR

    Energy Technology Data Exchange (ETDEWEB)

    Lai, W.; McCauley, E.W.

    1978-06-15

    Table-top model experiments were performed to investigate pressure suppression pool dynamics effects due to a postulated loss-of-coolant accident (LOCA) for the Peachbottom Mark I boiling water reactor containment system. The results guided subsequent conduct of experiments in the /sup 1///sub 5/-scale facility and provided new insight into the vertical load function (VLF). Model experiments show an oscillatory VLF with the download typically double-spiked followed by a more gradual sinusoidal upload. The load function contains a high frequency oscillation superimposed on a low frequency one; evidence from measurements indicates that the oscillations are initiated by fluid dynamics phenomena.

  2. Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models.

    Science.gov (United States)

    O'Neill, Jessica; Sikandar, Shafaq; McMahon, Stephen B; Dickenson, Anthony H

    2015-09-01

    Translational research is key to bridging the gaps between preclinical findings and the patients, and a translational model of inflammatory pain will ideally induce both peripheral and central sensitisation, more effectively mimicking clinical pathophysiology in some chronic inflammatory conditions. We conducted a parallel investigation of two models of inflammatory pain, using ultraviolet B (UVB) irradiation alone and UVB irradiation with heat rekindling. We used rodent electrophysiology and human quantitative sensory testing to characterise nociceptive processing in the peripheral and central nervous systems in both models. In both species, UVB irradiation produces peripheral sensitisation measured as augmented evoked activity of rat dorsal horn neurones and increased perceptual responses of human subjects to mechanical and thermal stimuli. In both species, UVB with heat rekindling produces central sensitisation. UVB irradiation alone and UVB with heat rekindling are translational models of inflammation that produce peripheral and central sensitisation, respectively. The predictive value of laboratory models for human pain processing is crucial for improving translational research. The discrepancy between peripheral and central mechanisms of pain is an important consideration for drug targets, and here we describe two models of inflammatory pain that involve ultraviolet B (UVB) irradiation, which can employ peripheral and central sensitisation to produce mechanical and thermal hyperalgesia in rats and humans. We use electrophysiology in rats to measure the mechanically- and thermally-evoked activity of rat spinal neurones and quantitative sensory testing to assess human psychophysical responses to mechanical and thermal stimulation in a model of UVB irradiation and in a model of UVB irradiation with heat rekindling. Our results demonstrate peripheral sensitisation in both species driven by UVB irradiation, with a clear mechanical and thermal hypersensitivity of

  3. Initial CGE Model Results Summary Exogenous and Endogenous Variables Tests

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Brian Keith [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Boero, Riccardo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rivera, Michael Kelly [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-07

    The following discussion presents initial results of tests of the most recent version of the National Infrastructure Simulation and Analysis Center Dynamic Computable General Equilibrium (CGE) model developed by Los Alamos National Laboratory (LANL). The intent of this is to test and assess the model’s behavioral properties. The test evaluated whether the predicted impacts are reasonable from a qualitative perspective. This issue is whether the predicted change, be it an increase or decrease in other model variables, is consistent with prior economic intuition and expectations about the predicted change. One of the purposes of this effort is to determine whether model changes are needed in order to improve its behavior qualitatively and quantitatively.

  4. Simulating lightning into the RAMS model: implementation and preliminary results

    Directory of Open Access Journals (Sweden)

    S. Federico

    2014-05-01

    Full Text Available This paper shows the results of a tailored version of a previously published methodology, designed to simulate lightning activity, implemented into the Regional Atmospheric Modeling System (RAMS. The method gives the flash density at the resolution of the RAMS grid-scale allowing for a detailed analysis of the evolution of simulated lightning activity. The system is applied in detail to two case studies occurred over the Lazio Region, in Central Italy. Simulations are compared with the lightning activity detected by the LINET network. The cases refer to two thunderstorms of different intensity. Results show that the model predicts reasonably well both cases and that the lightning activity is well reproduced especially for the most intense case. However, there are errors in timing and positioning of the convection, whose magnitude depends on the case study, which mirrors in timing and positioning errors of the lightning distribution. To assess objectively the performance of the methodology, standard scores are presented for four additional case studies. Scores show the ability of the methodology to simulate the daily lightning activity for different spatial scales and for two different minimum thresholds of flash number density. The performance decreases at finer spatial scales and for higher thresholds. The comparison of simulated and observed lighting activity is an immediate and powerful tool to assess the model ability to reproduce the intensity and the evolution of the convection. This shows the importance of the use of computationally efficient lightning schemes, such as the one described in this paper, in forecast models.

  5. Modeling air quality over China: Results from the Panda project

    Science.gov (United States)

    Katinka Petersen, Anna; Bouarar, Idir; Brasseur, Guy; Granier, Claire; Xie, Ying; Wang, Lili; Wang, Xuemei

    2015-04-01

    China faces strong air pollution problems related to rapid economic development in the past decade and increasing demand for energy. Air quality monitoring stations often report high levels of particle matter and ozone all over the country. Knowing its long-term health impacts, air pollution became then a pressing problem not only in China but also in other Asian countries. The PANDA project is a result of cooperation between scientists from Europe and China who joined their efforts for a better understanding of the processes controlling air pollution in China, improve methods for monitoring air quality and elaborate indicators in support of European and Chinese policies. A modeling system of air pollution is being setup within the PANDA project and include advanced global (MACC, EMEP) and regional (WRF-Chem, EMEP) meteorological and chemical models to analyze and monitor air quality in China. The poster describes the accomplishments obtained within the first year of the project. Model simulations for January and July 2010 are evaluated with satellite measurements (SCIAMACHY NO2 and MOPITT CO) and in-situ data (O3, CO, NOx, PM10 and PM2.5) observed at several surface stations in China. Using the WRF-Chem model, we investigate the sensitivity of the model performance to emissions (MACCity, HTAPv2), horizontal resolution (60km, 20km) and choice of initial and boundary conditions.

  6. Exact results for the one dimensional asymmetric exclusion model

    Science.gov (United States)

    Derrida, B.; Evans, M. R.; Hakim, V.; Pasquier, V.

    1993-11-01

    The asymmetric exclusion model describes a system of particles hopping in a preferred direction with hard core repulsion. These particles can be thought of as charged particles in a field, as steps of an interface, as cars in a queue. Several exact results concerning the steady state of this system have been obtained recently. The solution consists of representing the weights of the configurations in the steady state as products of non-commuting matrices.

  7. Exact results for the one dimensional asymmetric exclusion model

    Energy Technology Data Exchange (ETDEWEB)

    Derrida, B.; Evans, M.R.; Pasquier, V. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Service de Physique Theorique; Hakim, V. [Ecole Normale Superieure, 75 - Paris (France)

    1993-12-31

    The asymmetric exclusion model describes a system of particles hopping in a preferred direction with hard core repulsion. These particles can be thought of as charged particles in a field, as steps of an interface, as cars in a queue. Several exact results concerning the steady state of this system have been obtained recently. The solution consists of representing the weights of the configurations in the steady state as products of non-commuting matrices. (author).

  8. APPLYING LOGISTIC REGRESSION MODEL TO THE EXAMINATION RESULTS DATA

    Directory of Open Access Journals (Sweden)

    Goutam Saha

    2011-01-01

    Full Text Available The binary logistic regression model is used to analyze the school examination results(scores of 1002 students. The analysis is performed on the basis of the independent variables viz.gender, medium of instruction, type of schools, category of schools, board of examinations andlocation of schools, where scores or marks are assumed to be dependent variables. The odds ratioanalysis compares the scores obtained in two examinations viz. matriculation and highersecondary.

  9. Analytical results for a three-phase traffic model.

    Science.gov (United States)

    Huang, Ding-wei

    2003-10-01

    We study analytically a cellular automaton model, which is able to present three different traffic phases on a homogeneous highway. The characteristics displayed in the fundamental diagram can be well discerned by analyzing the evolution of density configurations. Analytical expressions for the traffic flow and shock speed are obtained. The synchronized flow in the intermediate-density region is the result of aggressive driving scheme and determined mainly by the stochastic noise.

  10. Challenges in validating model results for first year ice

    Science.gov (United States)

    Melsom, Arne; Eastwood, Steinar; Xie, Jiping; Aaboe, Signe; Bertino, Laurent

    2017-04-01

    In order to assess the quality of model results for the distribution of first year ice, a comparison with a product based on observations from satellite-borne instruments has been performed. Such a comparison is not straightforward due to the contrasting algorithms that are used in the model product and the remote sensing product. The implementation of the validation is discussed in light of the differences between this set of products, and validation results are presented. The model product is the daily updated 10-day forecast from the Arctic Monitoring and Forecasting Centre in CMEMS. The forecasts are produced with the assimilative ocean prediction system TOPAZ. Presently, observations of sea ice concentration and sea ice drift are introduced in the assimilation step, but data for sea ice thickness and ice age (or roughness) are not included. The model computes the age of the ice by recording and updating the time passed after ice formation as sea ice grows and deteriorates as it is advected inside the model domain. Ice that is younger than 365 days is classified as first year ice. The fraction of first-year ice is recorded as a tracer in each grid cell. The Ocean and Sea Ice Thematic Assembly Centre in CMEMS redistributes a daily product from the EUMETSAT OSI SAF of gridded sea ice conditions which include "ice type", a representation of the separation of regions between those infested by first year ice, and those infested by multi-year ice. The ice type is parameterized based on data for the gradient ratio GR(19,37) from SSMIS observations, and from the ASCAT backscatter parameter. This product also includes information on ambiguity in the processing of the remote sensing data, and the product's confidence level, which have a strong seasonal dependency.

  11. Superposition model analysis of nickel(II) ions in trigonal bipyramidal complexes exhibiting huge zero field splitting (aka 'giant magnetic anisotropy')

    Science.gov (United States)

    Rudowicz, Czesław; Açıkgöz, Muhammed; Gnutek, Paweł

    2017-07-01

    Potential single-ion magnet Ni2+ systems: [Ni(Me6tren)Cl](ClO4) and [Ni(Me6tren)Br](Br) reveal unusually high zero field splitting (ZFS). The ZFS parameter (ZFSP) Dexpt = -120 to -180 cm-1 was determined indirectly by high-magnetic field, high-frequency electron magnetic resonance (HMF-EMR). Modeling ZFSPs using the density functional theory (DFT) codes predicts D values: -100 to -200 cm-1. Such ZFSP values may seem controversial in view of the D values usually not exceeding several tens of cm-1 for Ni2+ ions. To corroborate or otherwise these results and elucidate the origin of the huge ZFS (named inappropriately as 'giant uniaxial magnetic anisotropy') and respective wavefunctions, we have undertaken semiempirical modeling based on the crystal field (CF) and spin Hamiltonians (SH) theory. In this paper, a feasibility study is carried out to ascertain if superposition model (SPM) calculations may yield such huge D values for these Ni2+ systems. Using crystal structure data for [Ni(Me6tren)Cl](ClO4) and [Ni(Me6tren)Br](Br) as well as taking into account the Jahn-Teller distortions of five-fold coordinated Ni-complexes revealed by DFT geometry optimization, the ZFSPs are predicted for several structural models and wide ranges of model parameters. The results indicate that in the presence of the Jahn-Teller distortions, the SPM-predicted ZFSP D may achieve the observed magnitudes, whereas the positive as well as negative D-signs are obtainable. Further studies based on SPM calculations of CF parameters and diagonalization of the Hamiltonian (Hfree ion + HCF) will allow considering the wavefunctions compositions and thus actual origin of the splitting between the ground and first excited state.

  12. Results of Satellite Brightness Modeling Using Kringing Optimized Interpolation

    Science.gov (United States)

    Weeden, C.; Hejduk, M.

    At the 2005 AMOS conference, Kriging Optimized Interpolation (KOI) was presented as a tool to model satellite brightness as a function of phase angle and solar declination angle (J.M Okada and M.D. Hejduk). Since November 2005, this method has been used to support the tasking algorithm for all optical sensors in the Space Surveillance Network (SSN). The satellite brightness maps generated by the KOI program are compared to each sensor's ability to detect an object as a function of the brightness of the background sky and angular rate of the object. This will determine if the sensor can technically detect an object based on an explicit calculation of the object's probability of detection. In addition, recent upgrades at Ground-Based Electro Optical Deep Space Surveillance Sites (GEODSS) sites have increased the amount and quality of brightness data collected and therefore available for analysis. This in turn has provided enough data to study the modeling process in more detail in order to obtain the most accurate brightness prediction of satellites. Analysis of two years of brightness data gathered from optical sensors and modeled via KOI solutions are outlined in this paper. By comparison, geo-stationary objects (GEO) were tracked less than non-GEO objects but had higher density tracking in phase angle due to artifices of scheduling. A statistically-significant fit to a deterministic model was possible less than half the time in both GEO and non-GEO tracks, showing that a stochastic model must often be used alone to produce brightness results, but such results are nonetheless serviceable. Within the Kriging solution, the exponential variogram model was the most frequently employed in both GEO and non-GEO tracks, indicating that monotonic brightness variation with both phase and solar declination angle is common and testifying to the suitability to the application of regionalized variable theory to this particular problem. Finally, the average nugget value, or

  13. Titan Chemistry: Results From A Global Climate Model

    Science.gov (United States)

    Wilson, Eric; West, R. A.; Friedson, A. J.; Oyafuso, F.

    2008-09-01

    We present results from a 3-dimesional global climate model of Titan's atmosphere and surface. This model, a modified version of NCAR's CAM-3 (Community Atmosphere Model), has been optimized for analysis of Titan's lower atmosphere and surface. With the inclusion of forcing from Saturn's gravitational tides, interaction from the surface, transfer of longwave and shortwave radiation, and parameterization of haze properties, constrained by Cassini observations, a dynamical field is generated, which serves to advect 14 long-lived species. The concentrations of these chemical tracers are also affected by 82 chemical reactions and the photolysis of 21 species, based on the Wilson and Atreya (2004) model, that provide sources and sinks for the advected species along with 23 additional non-advected radicals. In addition, the chemical contribution to haze conversion is parameterized along with the microphysical processes that serve to distribute haze opacity throughout the atmosphere. References Wilson, E.H. and S.K. Atreya, J. Geophys. Res., 109, E06002, 2004.

  14. Why Does a Kronecker Model Result in Misleading Capacity Estimates?

    CERN Document Server

    Raghavan, Vasanthan; Sayeed, Akbar M

    2008-01-01

    Many recent works that study the performance of multi-input multi-output (MIMO) systems in practice assume a Kronecker model where the variances of the channel entries, upon decomposition on to the transmit and the receive eigen-bases, admit a separable form. Measurement campaigns, however, show that the Kronecker model results in poor estimates for capacity. Motivated by these observations, a channel model that does not impose a separable structure has been recently proposed and shown to fit the capacity of measured channels better. In this work, we show that this recently proposed modeling framework can be viewed as a natural consequence of channel decomposition on to its canonical coordinates, the transmit and/or the receive eigen-bases. Using tools from random matrix theory, we then establish the theoretical basis behind the Kronecker mismatch at the low- and the high-SNR extremes: 1) Sparsity of the dominant statistical degrees of freedom (DoF) in the true channel at the low-SNR extreme, and 2) Non-regul...

  15. Some Results on Optimal Dividend Problem in Two Risk Models

    Directory of Open Access Journals (Sweden)

    Shuaiqi Zhang

    2010-12-01

    Full Text Available The compound Poisson risk model and the compound Poisson risk model perturbed by diffusion are considered in the presence of a dividend barrier with solvency constraints. Moreover, it extends the known result due to [1]. Ref. [1] finds the optimal dividend policy is of a barrier type for a jump-diffusion model with exponentially distributed jumps. In this paper, it turns out that there can be two different solutions depending on the model’s parameters. Furthermore, an interesting result is given: the proportional transaction cost has no effect on the dividend barrier. The objective of the corporation is to maximize the cumulative expected discounted dividends payout with solvency constraints before the time of ruin. It is well known that under some reasonable assumptions, optimal dividend strategy is a barrier strategy, i.e., there is a level b_{1}(b_{2} so that whenever surplus goes above the level b_{1}(b_{2}, the excess is paid out as dividends. However, the optimal level b_{1}(b_{2} may be unacceptably low from a solvency point of view. Therefore, some constraints should imposed on an insurance company such as to pay out dividends unless the surplus has reached a level b^{1}_{c}>b_{1}(b^2_{c}>b_{2} . We show that in this case a barrier strategy at b^{1}_{c}(b^2_{c} is optimal.

  16. Modeling results for the ITER cryogenic fore pump

    Science.gov (United States)

    Zhang, D. S.; Miller, F. K.; Pfotenhauer, J. M.

    2014-01-01

    The cryogenic fore pump (CFP) is designed for ITER to collect and compress hydrogen isotopes during the regeneration process of torus cryopumps. Different from common cryopumps, the ITER-CFP works in the viscous flow regime. As a result, both adsorption boundary conditions and transport phenomena contribute unique features to the pump performance. In this report, the physical mechanisms of cryopumping are studied, especially the diffusion-adsorption process and these are coupled with standard equations of species, momentum and energy balance, as well as the equation of state. Numerical models are developed, which include highly coupled non-linear conservation equations of species, momentum and energy and equation of state. Thermal and kinetic properties are treated as functions of temperature, pressure, and composition. To solve such a set of equations, a novel numerical technique, identified as the Group-Member numerical technique is proposed. It is presented here a 1D numerical model. The results include comparison with the experimental data of pure hydrogen flow and a prediction for hydrogen flow with trace helium. An advanced 2D model and detailed explanation of the Group-Member technique are to be presented in following papers.

  17. 2007Fairs & Exhibitions in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 6th China (Guangzhou) International Seasoning Exhibition Date: May 11-13 Founded in: 2003.05 Venues: Guangzhou Int'l Convention &Exhibition Center (Pazhou) Exhibits: Seasonings, food additives, relevant material,equipment, service and publications

  18. 2005 Fairs & Exhibitions in China

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Harbin China International Winter Goods Exhibition DATE: Jan. 5-9 FREQUENCY: Annual FOUNDED TIME: Dec. 2001 VENUE: Harbin China International Conference & Exhibition Center EXHIBITS: winter sports goods and outdoor devices

  19. SR-Site groundwater flow modelling methodology, setup and results

    Energy Technology Data Exchange (ETDEWEB)

    Selroos, Jan-Olof (Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)); Follin, Sven (SF GeoLogic AB, Taeby (Sweden))

    2010-12-15

    As a part of the license application for a final repository for spent nuclear fuel at Forsmark, the Swedish Nuclear Fuel and Waste Management Company (SKB) has undertaken three groundwater flow modelling studies. These are performed within the SR-Site project and represent time periods with different climate conditions. The simulations carried out contribute to the overall evaluation of the repository design and long-term radiological safety. Three time periods are addressed; the Excavation and operational phases, the Initial period of temperate climate after closure, and the Remaining part of the reference glacial cycle. The present report is a synthesis of the background reports describing the modelling methodology, setup, and results. It is the primary reference for the conclusions drawn in a SR-Site specific context concerning groundwater flow during the three climate periods. These conclusions are not necessarily provided explicitly in the background reports, but are based on the results provided in these reports. The main results and comparisons presented in the present report are summarised in the SR-Site Main report.

  20. Geochemical controls on shale groundwaters: Results of reaction path modeling

    Energy Technology Data Exchange (ETDEWEB)

    Von Damm, K.L.; VandenBrook, A.J.

    1989-03-01

    The EQ3NR/EQ6 geochemical modeling code was used to simulate the reaction of several shale mineralogies with different groundwater compositions in order to elucidate changes that may occur in both the groundwater compositions, and rock mineralogies and compositions under conditions which may be encountered in a high-level radioactive waste repository. Shales with primarily illitic or smectitic compositions were the focus of this study. The reactions were run at the ambient temperatures of the groundwaters and to temperatures as high as 250/degree/C, the approximate temperature maximum expected in a repository. All modeling assumed that equilibrium was achieved and treated the rock and water assemblage as a closed system. Graphite was used as a proxy mineral for organic matter in the shales. The results show that the presence of even a very small amount of reducing mineral has a large influence on the redox state of the groundwaters, and that either pyrite or graphite provides essentially the same results, with slight differences in dissolved C, Fe and S concentrations. The thermodynamic data base is inadequate at the present time to fully evaluate the speciation of dissolved carbon, due to the paucity of thermodynamic data for organic compounds. In the illitic cases the groundwaters resulting from interaction at elevated temperatures are acid, while the smectitic cases remain alkaline, although the final equilibrium mineral assemblages are quite similar. 10 refs., 8 figs., 15 tabs.

  1. Multi-Model Combination techniques for Hydrological Forecasting: Application to Distributed Model Intercomparison Project Results

    Energy Technology Data Exchange (ETDEWEB)

    Ajami, N K; Duan, Q; Gao, X; Sorooshian, S

    2005-04-11

    This paper examines several multi-model combination techniques: the Simple Multi-model Average (SMA), the Multi-Model Super Ensemble (MMSE), Modified Multi-Model Super Ensemble (M3SE) and the Weighted Average Method (WAM). These model combination techniques were evaluated using the results from the Distributed Model Intercomparison Project (DMIP), an international project sponsored by the National Weather Service (NWS) Office of Hydrologic Development (OHD). All of the multi-model combination results were obtained using uncalibrated DMIP model outputs and were compared against the best uncalibrated as well as the best calibrated individual model results. The purpose of this study is to understand how different combination techniques affect the skill levels of the multi-model predictions. This study revealed that the multi-model predictions obtained from uncalibrated single model predictions are generally better than any single member model predictions, even the best calibrated single model predictions. Furthermore, more sophisticated multi-model combination techniques that incorporated bias correction steps work better than simple multi-model average predictions or multi-model predictions without bias correction.

  2. VNIR spectral modeling of Mars analogue rocks: first results

    Science.gov (United States)

    Pompilio, L.; Roush, T.; Pedrazzi, G.; Sgavetti, M.

    Knowledge regarding the surface composition of Mars and other bodies of the inner solar system is fundamental to understanding of their origin, evolution, and internal structures. Technological improvements of remote sensors and associated implications for planetary studies have encouraged increased laboratory and field spectroscopy research to model the spectral behavior of terrestrial analogues for planetary surfaces. This approach has proven useful during Martian surface and orbital missions, and petrologic studies of Martian SNC meteorites. Thermal emission data were used to suggest two lithologies occurring on Mars surface: basalt with abundant plagioclase and clinopyroxene and andesite, dominated by plagioclase and volcanic glass [1,2]. Weathered basalt has been suggested as an alternative to the andesite interpretation [3,4]. Orbital VNIR spectral imaging data also suggest the crust is dominantly basaltic, chiefly feldspar and pyroxene [5,6]. A few outcrops of ancient crust have higher concentrations of olivine and low-Ca pyroxene, and have been interpreted as cumulates [6]. Based upon these orbital observations future lander/rover missions can be expected to encounter particulate soils, rocks, and rock outcrops. Approaches to qualitative and quantitative analysis of remotely-acquired spectra have been successfully used to infer the presence and abundance of minerals and to discover compositionally associated spectral trends [7-9]. Both empirical [10] and mathematical [e.g. 11-13] methods have been applied, typically with full compositional knowledge, to chiefly particulate samples and as a result cannot be considered as objective techniques for predicting the compositional information, especially for understanding the spectral behavior of rocks. Extending the compositional modeling efforts to include more rocks and developing objective criteria in the modeling are the next required steps. This is the focus of the present investigation. We present results of

  3. ITER CS Model Coil and CS Insert Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N; Michael, P; Minervina, J; Radovinsky, A; Takayasu, M; Thome, R; Ando, T; Isono, T; Kato, T; Nakajima, H; Nishijima, G; Nunoya, Y; Sugimoto, M; Takahashi, Y; Tsuji, H; Bessette, D; Okuno, K; Ricci, M

    2000-09-07

    The Inner and Outer modules of the Central Solenoid Model Coil (CSMC) were built by US and Japanese home teams in collaboration with European and Russian teams to demonstrate the feasibility of a superconducting Central Solenoid for ITER and other large tokamak reactors. The CSMC mass is about 120 t, OD is about 3.6 m and the stored energy is 640 MJ at 46 kA and peak field of 13 T. Testing of the CSMC and the CS Insert took place at Japan Atomic Energy Research Institute (JAERI) from mid March until mid August 2000. This paper presents the main results of the tests performed.

  4. Results of the benchmark for blade structural models, part A

    DEFF Research Database (Denmark)

    Lekou, D.J.; Chortis, D.; Belen Fariñas, A.;

    2013-01-01

    Task 2.2 of the InnWind.Eu project. The benchmark is based on the reference wind turbine and the reference blade provided by DTU [1]. "Structural Concept developers/modelers" of WP2 were provided with the necessary input for a comparison numerical simulation run, upon definition of the reference blade......A benchmark on structural design methods for blades was performed within the InnWind.Eu project under WP2 “Lightweight Rotor” Task 2.2 “Lightweight structural design”. The present document is describes the results of the comparison simulation runs that were performed by the partners involved within...

  5. Model independent analysis of dark energy I: Supernova fitting result

    CERN Document Server

    Gong, Y

    2004-01-01

    The nature of dark energy is a mystery to us. This paper uses the supernova data to explore the property of dark energy by some model independent methods. We first Talyor expanded the scale factor $a(t)$ to find out the deceleration parameter $q_0<0$. This result just invokes the Robertson-Walker metric. Then we discuss several different parameterizations used in the literature. We find that $\\Omega_{\\rm DE0}$ is almost less than -1 at $1\\sigma$ level. We also find that the transition redshift from deceleration phase to acceleration phase is $z_{\\rm T}\\sim 0.3$.

  6. Preliminary results of steel containment vessel model test

    Energy Technology Data Exchange (ETDEWEB)

    Luk, V.K.; Hessheimer, M.F. [Sandia National Labs., Albuquerque, NM (United States); Matsumoto, T.; Komine, K.; Arai, S. [Nuclear Power Engineering Corp., Tokyo (Japan); Costello, J.F. [Nuclear Regulatory Commission, Washington, DC (United States)

    1998-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11--12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  7. Multi-Model Combination Techniques for Hydrological Forecasting: Application to Distributed Model Intercomparison Project Results

    Energy Technology Data Exchange (ETDEWEB)

    Ajami, N; Duan, Q; Gao, X; Sorooshian, S

    2006-05-08

    This paper examines several multi-model combination techniques: the Simple Multimodel Average (SMA), the Multi-Model Super Ensemble (MMSE), Modified Multi-Model Super Ensemble (M3SE) and the Weighted Average Method (WAM). These model combination techniques were evaluated using the results from the Distributed Model Intercomparison Project (DMIP), an international project sponsored by the National Weather Service (NWS) Office of Hydrologic Development (OHD). All of the multi-model combination results were obtained using uncalibrated DMIP model outputs and were compared against the best uncalibrated as well as the best calibrated individual model results. The purpose of this study is to understand how different combination techniques affect the skill levels of the multi-model predictions. This study revealed that the multi-model predictions obtained from uncalibrated single model predictions are generally better than any single member model predictions, even the best calibrated single model predictions. Furthermore, more sophisticated multi-model combination techniques that incorporated bias correction steps work better than simple multi-model average predictions or multi-model predictions without bias correction.

  8. Designing an exhibition

    DEFF Research Database (Denmark)

    Ingemann, Bruno

    2010-01-01

    by following the design-thinking processes in detail. The fundamental concept is an introverted analysis completed by giving one person two roles, that of designer and researcher. The result is a dialogue concerning the processual experience as a reflection-in-action. The contribution to a general core...

  9. Impact Flash Physics: Modeling and Comparisons With Experimental Results

    Science.gov (United States)

    Rainey, E.; Stickle, A. M.; Ernst, C. M.; Schultz, P. H.; Mehta, N. L.; Brown, R. C.; Swaminathan, P. K.; Michaelis, C. H.; Erlandson, R. E.

    2015-12-01

    horizontal. High-speed radiometer measurements were made of the time-dependent impact flash at wavelengths of 350-1100 nm. We will present comparisons between these measurements and the output of APL's model. The results of this validation allow us to determine basic relationships between observed optical signatures and impact conditions.

  10. Subsea Permafrost Climate Modeling - Challenges and First Results

    Science.gov (United States)

    Rodehacke, C. B.; Stendel, M.; Marchenko, S. S.; Christensen, J. H.; Romanovsky, V. E.; Nicolsky, D.

    2015-12-01

    Recent observations indicate that the East Siberian Arctic Shelf (ESAS) releases methane, which stems from shallow hydrate seabed reservoirs. The total amount of carbon within the ESAS is so large that release of only a small fraction, for example via taliks, which are columns of unfrozen sediment within the permafrost, could impact distinctly the global climate. Therefore it is crucial to simulate the future fate of ESAS' subsea permafrost with regard to changing atmospheric and oceanic conditions. However only very few attempts to address the vulnerability of subsea permafrost have been made, instead most studies have focused on the evolution of permafrost since the Late Pleistocene ocean transgression, approximately 14000 years ago.In contrast to land permafrost modeling, any attempt to model the future fate of subsea permafrost needs to consider several additional factors, in particular the dependence of freezing temperature on water depth and salt content and the differences in ground heat flux depending on the seabed properties. Also the amount of unfrozen water in the sediment needs to be taken into account. Using a system of coupled ocean, atmosphere and permafrost models will allow us to capture the complexity of the different parts of the system and evaluate the relative importance of different processes. Here we present the first results of a novel approach by means of dedicated permafrost model simulations. These have been driven by conditions of the Laptev Sea region in East Siberia. By exploiting the ensemble approach, we will show how uncertainties in boundary conditions and applied forcing scenarios control the future fate of the sub sea permafrost.

  11. DARK STARS: IMPROVED MODELS AND FIRST PULSATION RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Rindler-Daller, T.; Freese, K. [Department of Physics and Michigan Center for Theoretical Physics, University of Michigan, Ann Arbor, MI 48109 (United States); Montgomery, M. H.; Winget, D. E. [Department of Astronomy, McDonald Observatory and Texas Cosmology Center, University of Texas, Austin, TX 78712 (United States); Paxton, B. [Kavli Insitute for Theoretical Physics, University of California, Santa Barbara, CA 93106 (United States)

    2015-02-01

    We use the stellar evolution code MESA to study dark stars (DSs). DSs, which are powered by dark matter (DM) self-annihilation rather than by nuclear fusion, may be the first stars to form in the universe. We compute stellar models for accreting DSs with masses up to 10{sup 6} M {sub ☉}. The heating due to DM annihilation is self-consistently included, assuming extended adiabatic contraction of DM within the minihalos in which DSs form. We find remarkably good overall agreement with previous models, which assumed polytropic interiors. There are some differences in the details, with positive implications for observability. We found that, in the mass range of 10{sup 4}-10{sup 5} M {sub ☉}, our DSs are hotter by a factor of 1.5 than those in Freese et al., are smaller in radius by a factor of 0.6, denser by a factor of three to four, and more luminous by a factor of two. Our models also confirm previous results, according to which supermassive DSs are very well approximated by (n = 3)-polytropes. We also perform a first study of DS pulsations. Our DS models have pulsation modes with timescales ranging from less than a day to more than two years in their rest frames, at z ∼ 15, depending on DM particle mass and overtone number. Such pulsations may someday be used to identify bright, cool objects uniquely as DSs; if properly calibrated, they might, in principle, also supply novel standard candles for cosmological studies.

  12. Convergence results for a coarsening model using global linearization

    CERN Document Server

    Gallay, T; Gallay, Th.

    2002-01-01

    We study a coarsening model describing the dynamics of interfaces in the one-dimensional Allen-Cahn equation. Given a partition of the real line into intervals of length greater than one, the model consists in constantly eliminating the shortest interval of the partition by merging it with its two neighbors. We show that the mean-field equation for the time-dependent distribution of interval lengths can be explicitly solved using a global linearization transformation. This allows us to derive rigorous results on the long-time asymptotics of the solutions. If the average length of the intervals is finite, we prove that all distributions approach a uniquely determined self-similar solution. We also obtain global stability results for the family of self-similar profiles which correspond to distributions with infinite expectation. eliminating the shortest interval of the partition by merging it with its two neighbors. We show that the mean-field equation for the time-dependent distribution of interval lengths can...

  13. Compressible Turbulent Channel Flows: DNS Results and Modeling

    Science.gov (United States)

    Huang, P. G.; Coleman, G. N.; Bradshaw, P.; Rai, Man Mohan (Technical Monitor)

    1994-01-01

    The present paper addresses some topical issues in modeling compressible turbulent shear flows. The work is based on direct numerical simulation of two supersonic fully developed channel flows between very cold isothermal walls. Detailed decomposition and analysis of terms appearing in the momentum and energy equations are presented. The simulation results are used to provide insights into differences between conventional time-and Favre-averaging of the mean-flow and turbulent quantities. Study of the turbulence energy budget for the two cases shows that the compressibility effects due to turbulent density and pressure fluctuations are insignificant. In particular, the dilatational dissipation and the mean product of the pressure and dilatation fluctuations are very small, contrary to the results of simulations for sheared homogeneous compressible turbulence and to recent proposals for models for general compressible turbulent flows. This provides a possible explanation of why the Van Driest density-weighted transformation is so successful in correlating compressible boundary layer data. Finally, it is found that the DNS data do not support the strong Reynolds analogy. A more general representation of the analogy is analysed and shown to match the DNS data very well.

  14. Mobile Technologies in Museum Exhibitions

    Directory of Open Access Journals (Sweden)

    Sandra Medić

    2014-10-01

    Full Text Available In order to be up–to–date and give visitors a memorable and unique experience, museums are including usage of digital technologies in their exhibitions. Even though museums in Serbia are very important part of tourism offer, they still have traditional settings that are poorly interpreted. The majority of them have a scientific and historical review which is unattractive for various target groups of visitors and for museums it’s important to continually try out new ways in interpretation of their settings. Because technology continues to rapidly change the way we communicate, cultural institutions should adapt to new ways of communication with their visitors. This paper examines mobile technologies that can be used in museums to give visitors a different experience and transfer the knowledge innovatively. In that way it will be presented the modern concept of presentation of museum exhibitions, focusing on usage of mobile devices through mobile applications and QR codes. The paper provides the broad understanding of usage mobile technologies in museum exhibitions with its advantages and limitations. The research results can help the museums management to improve interpretation and communication with visitors and enrich the visitor experience.

  15. Numerical Results of 3-D Modeling of Moon Accumulation

    Science.gov (United States)

    Khachay, Yurie; Anfilogov, Vsevolod; Antipin, Alexandr

    2014-05-01

    For the last time for the model of the Moon usually had been used the model of mega impact in which the forming of the Earth and its sputnik had been the consequence of the Earth's collision with the body of Mercurial mass. But all dynamical models of the Earth's accumulation and the estimations after the Pb-Pb system, lead to the conclusion that the duration of the planet accumulation was about 1 milliard years. But isotopic results after the W-Hf system testify about a very early (5-10) million years, dividing of the geochemical reservoirs of the core and mantle. In [1,2] it is shown, that the account of energy dissipating by the decay of short living radioactive elements and first of all Al26,it is sufficient for heating even small bodies with dimensions about (50-100) km up to the iron melting temperature and can be realized a principal new differentiation mechanism. The inner parts of the melted preplanets can join and they are mainly of iron content, but the cold silicate fragments return to the supply zone and additionally change the content of Moon forming to silicates. Only after the increasing of the gravitational radius of the Earth, the growing area of the future Earth's core can save also the silicate envelope fragments [3]. For understanding the further system Earth-Moon evolution it is significant to trace the origin and evolution of heterogeneities, which occur on its accumulation stage.In that paper we are modeling the changing of temperature,pressure,velocity of matter flowing in a block of 3d spherical body with a growing radius. The boundary problem is solved by the finite-difference method for the system of equations, which include equations which describe the process of accumulation, the Safronov equation, the equation of impulse balance, equation Navier-Stocks, equation for above litho static pressure and heat conductivity in velocity-pressure variables using the Businesque approach.The numerical algorithm of the problem solution in velocity

  16. Ballroom Music Spillover into a Beluga Whale Aquarium Exhibit

    Directory of Open Access Journals (Sweden)

    Peter M. Scheifele

    2012-01-01

    Full Text Available It is not uncommon for modern aquaria to be built with special entertainment areas. There are no known measurements of sound spillover from such entertainment areas into underwater animal exhibits. Entertainment organizations typically prefer to play music for events at 95 and 100 dBA in a ballroom at Georgia Aquarium. Concern over the potential effects of the music and noise on animals in adjacent exhibits inspired an initial project to monitor and compare sound levels in the adjacent underwater exhibits against the typical in-air sound levels of the ballroom. Measured underwater noise levels were compared to modeled levels based on finite element analysis and plane wave transmission loss calculations through the acrylic viewing window. Results were compared with the model to determine how, if at all, the ambient noise level in the Cold Water Quest exhibit changed as a result of music played in the ballroom.

  17. Comparison of blade-strike modeling results with empirical data

    Energy Technology Data Exchange (ETDEWEB)

    Ploskey, Gene R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carlson, Thomas J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2004-03-01

    This study is the initial stage of further investigation into the dynamics of injury to fish during passage through a turbine runner. As part of the study, Pacific Northwest National Laboratory (PNNL) estimated the probability of blade strike, and associated injury, as a function of fish length and turbine operating geometry at two adjacent turbines in Powerhouse 1 of Bonneville Dam. Units 5 and 6 had identical intakes, stay vanes, wicket gates, and draft tubes, but Unit 6 had a new runner and curved discharge ring to minimize gaps between the runner hub and blades and between the blade tips and discharge ring. We used a mathematical model to predict blade strike associated with two Kaplan turbines and compared results with empirical data from biological tests conducted in 1999 and 2000. Blade-strike models take into consideration the geometry of the turbine blades and discharges as well as fish length, orientation, and distribution along the runner. The first phase of this study included a sensitivity analysis to consider the effects of difference in geometry and operations between families of turbines on the strike probability response surface. The analysis revealed that the orientation of fish relative to the leading edge of a runner blade and the location that fish pass along the blade between the hub and blade tip are critical uncertainties in blade-strike models. Over a range of discharges, the average prediction of injury from blade strike was two to five times higher than average empirical estimates of visible injury from shear and mechanical devices. Empirical estimates of mortality may be better metrics for comparison to predicted injury rates than other injury measures for fish passing at mid-blade and blade-tip locations.

  18. Position-sensitive transition edge sensor modeling and results

    Energy Technology Data Exchange (ETDEWEB)

    Hammock, Christina E-mail: chammock@milkyway.gsfc.nasa.gov; Figueroa-Feliciano, Enectali; Apodaca, Emmanuel; Bandler, Simon; Boyce, Kevin; Chervenak, Jay; Finkbeiner, Fred; Kelley, Richard; Lindeman, Mark; Porter, Scott; Saab, Tarek; Stahle, Caroline

    2004-03-11

    We report the latest design and experimental results for a Position-Sensitive Transition-Edge Sensor (PoST). The PoST is motivated by the desire to achieve a larger field-of-view without increasing the number of readout channels. A PoST consists of a one-dimensional array of X-ray absorbers connected on each end to a Transition Edge Sensor (TES). Position differentiation is achieved through a comparison of pulses between the two TESs and X-ray energy is inferred from a sum of the two signals. Optimizing such a device involves studying the available parameter space which includes device properties such as heat capacity and thermal conductivity as well as TES read-out circuitry parameters. We present results for different regimes of operation and the effects on energy resolution, throughput, and position differentiation. Results and implications from a non-linear model developed to study the saturation effects unique to PoSTs are also presented.

  19. Dark Stars: Improved Models and First Pulsation Results

    CERN Document Server

    Rindler-Daller, Tanja; Freese, Katherine; Winget, Donald E; Paxton, Bill

    2014-01-01

    (Abridged) We use the stellar evolution code MESA to study dark stars. Dark stars (DSs), which are powered by dark matter (DM) self-annihilation rather than by nuclear fusion, may be the first stars to form in the Universe. We compute stellar models for accreting DSs with masses up to 10^6 M_sun. While previous calculations were limited to polytropic interiors, our current calculations use MESA, a modern stellar evolution code to solve the equations of stellar structure. The heating due to DM annihilation is self-consistently included, assuming extended adiabatic contraction of DM within the minihalos in which DSs form. We find remarkably good overall agreement with the basic results of previous models. There are some differences, however, in the details, with positive implications for observability of DSs. We found that, in the mass range of 10^4 - 10^5 M_sun, using MESA, our DSs are hotter by a factor of 1.5 than those in Freese et al.(2010), are smaller in radius by a factor of 0.6, denser by a factor of 3...

  20. Dipole model test with one superconducting coil; results analysed

    CERN Document Server

    Durante, M; Ferracin, P; Fessia, P; Gauthier, R; Giloux, C; Guinchard, M; Kircher, F; Manil, P; Milanese, A; Millot, J-F; Muñoz Garcia, J-E; Oberli, L; Perez, J-C; Pietrowicz, S; Rifflet, J-M; de Rijk, G; Rondeaux, F; Todesco, E; Viret, P; Ziemianski, D

    2013-01-01

    This report is the deliverable report 7.3.1 “Dipole model test with one superconducting coil; results analysed “. The report has four parts: “Design report for the dipole magnet”, “Dipole magnet structure tested in LN2”, “Nb3Sn strand procured for one dipole magnet” and “One test double pancake copper coil made”. The 4 report parts show that, although the magnet construction will be only completed by end 2014, all elements are present for a successful completion. Due to the importance of the project for the future of the participants and given the significant investments done by the participants, there is a full commitment to finish the project.

  1. Dipole model test with one superconducting coil: results analysed

    CERN Document Server

    Bajas, H; Benda, V; Berriaud, C; Bajko, M; Bottura, L; Caspi, S; Charrondiere, M; Clément, S; Datskov, V; Devaux, M; Durante, M; Fazilleau, P; Ferracin, P; Fessia, P; Gauthier, R; Giloux, C; Guinchard, M; Kircher, F; Manil, P; Milanese, A; Millot, J-F; Muñoz Garcia, J-E; Oberli, L; Perez, J-C; Pietrowicz, S; Rifflet, J-M; de Rijk, G; Rondeaux, F; Todesco, E; Viret, P; Ziemianski, D

    2013-01-01

    This report is the deliverable report 7.3.1 “Dipole model test with one superconducting coil; results analysed “. The report has four parts: “Design report for the dipole magnet”, “Dipole magnet structure tested in LN2”, “Nb3Sn strand procured for one dipole magnet” and “One test double pancake copper coil made”. The 4 report parts show that, although the magnet construction will be only completed by end 2014, all elements are present for a successful completion. Due to the importance of the project for the future of the participants and given the significant investments done by the participants, there is a full commitment to finish the project.

  2. Further Results on Dynamic Additive Hazard Rate Model

    Directory of Open Access Journals (Sweden)

    Zhengcheng Zhang

    2014-01-01

    Full Text Available In the past, the proportional and additive hazard rate models have been investigated in the works. Nanda and Das (2011 introduced and studied the dynamic proportional (reversed hazard rate model. In this paper we study the dynamic additive hazard rate model, and investigate its aging properties for different aging classes. The closure of the model under some stochastic orders has also been investigated. Some examples are also given to illustrate different aging properties and stochastic comparisons of the model.

  3. SKLB-287, a novel oral multikinase inhibitor of EGFR and VEGFR2, exhibits potent antitumor activity in LoVo colorectal tumor model.

    Science.gov (United States)

    Chen, X; Liu, Y; Yang, H-W; Zhou, S; Cheng, C; Zheng, M-W; Zhong, L; Fu, X-Y; Pan, Y-L; Ma, S; Tang, Y; Chen, Y-Z; Li, L-L; Yang, S-Y

    2014-01-01

    Colorectal cancer (CRC) is the third common cancer and most of the chemotherapies of CRC currently used often suffer limited efficacy and large side effects. Targeted small-molecule by anti-tumor drugs are thought a promising strategy for improving the efficacy and reducing the side effects. In this investigation, we report a novel multikinase inhibitor, termed SKLB-287, which was discovered by us recently. SKLB-287 could efficiently inhibit the activation of endothelial growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2). It displayed very good anti-proliferative activity against LoVo CRC cells and considerable antiangiogenic potency in transgenic zebrafish embryos. Oral administration of SKLB-287 resulted in dose-dependent suppression of tumor growth in LoVo xenograft mouse model. Immunohistochemistry was adopted to examine the in vivo anti-tumor mechanism of action of SKLB-287.

  4. The fruit cuticles of wild tomato species exhibit architectural and chemical diversity, providing a new model for studying the evolution of cuticle function.

    Science.gov (United States)

    Yeats, Trevor H; Buda, Gregory J; Wang, Zhonghua; Chehanovsky, Noam; Moyle, Leonie C; Jetter, Reinhard; Schaffer, Arthur A; Rose, Jocelyn K C

    2012-02-01

    The cuticle covers the aerial epidermis of land plants and plays a primary role in water regulation and protection from external stresses. Remarkable species diversity in the structure and composition of its components, cutin and wax, have been catalogued, but few functional or genetic correlations have emerged. Tomato (Solanum lycopersicum) is part of a complex of closely related wild species endemic to the northern Andes and the Galapagos Islands (Solanum Sect. Lycopersicon). Although sharing an ancestor wild species exceeding that of S. lycopersicum by up to seven fold. Wax composition varied in the occurrence of wax esters and triterpenoid isomers. Using a Solanum habrochaites introgression line population, we mapped triterpenoid differences to a genomic region that includes two S. lycopersicum triterpene synthases. Based on known metabolic pathways for acyl wax compounds, hypotheses are discussed to explain the appearance of wax esters with atypical chain lengths. These results establish a model system for understanding the ecological and evolutionary functional genomics of plant cuticles.

  5. A Duality Result for the Generalized Erlang Risk Model

    Directory of Open Access Journals (Sweden)

    Lanpeng Ji

    2014-11-01

    Full Text Available In this article, we consider the generalized Erlang risk model and its dual model. By using a conditional measure-preserving correspondence between the two models, we derive an identity for two interesting conditional probabilities. Applications to the discounted joint density of the surplus prior to ruin and the deficit at ruin are also discussed.

  6. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Gaïa Manuella Cany Du 10 au 28 avril 2017 CERN Meyrin, Bâtiment principal Oiseau - Manuella Cany. Tableaux abstraits inspirés de vues satellites ou photos prises du ciel. Certains sont à la frontière du figuratif alors que d'autres permettent de laisser libre cours à son imagination. Aux détails infinis, ces tableaux sont faits pour être vus de loin et de près grâce à une attention toute particulière apportée aux effets de matières et aux couleurs le long de volutes tantôt nuancées tantôt contrastées.   Pour plus d’informations : staff.association@cern.ch | Tél: 022 766 37 38

  7. Exhibition

    CERN Multimedia

    Staff Association

    2014-01-01

      Parallels vision Astronomical subjects which evoke extrasensory kinetic visions Alberto Di Fabio From 8 to 10 October, CERN Meyrin, Main Building In the framework of Italy@cern, the Staff Association presents Alberto Di Fabio. Di Fabio’s work is inspired by the fundamental laws of the physical world, as well as organic elements and their interrelation. His paintings and works on paper merge the worlds of art and science, depicting natural forms and biological structures in vivid colour and imaginative detail. For all additional information: staff.association@cern.ch | Tel: 022 767 28 19

  8. Exhibition

    CERN Multimedia

    Staff Association

    2011-01-01

    Jan Hladky, physicien de l'Institut de Physique de l'Académie des Sciences de la République tchèque, et membre de la collaboration Alice, expose ses œuvres au Bâtiment principal du 20 avril au 6 mai. Son exposition est dédiée aux victimes du séisme de Sendai. Des copies de ses œuvres seront mises en vente et les sommes récoltées seront versées au profit des victimes.

  9. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    The Elementary Particles of Painting Alfonso Fratteggiani Bianchi and Ermanno Imbergamo From September 26 to October 7, 2016 CERN Meyrin, Main Building With intentions similar to those of CERN physicists, the artist Alfonso Fratteggiani Bianchi investigates the color pigment, studying its interaction with light and with the support on which it is deposited. He creates monochrome paintings by spreading the color pigment in the pure state on stones, without using glue or any other type of adhesive. With intentions similar to artists, the physicist Ermanno Imbergamo investigates the use of luminescent wavelength shifters, materials commonly used in Particle Physics, for art. He creates other monochrome artworks, which disclose further aspects of interaction among light, color pigments and support. For more information: staff.association@cern.ch | Tel: 022 767 28 19

  10. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    La mosaïque ou quand détruire permet de construire Lauren Decamps Du 28 novembre au 9 décembre 2016 CERN Meyrin, Bâtiment principal Paysage d'Amsterdam - Lauren Decamps On ne doit jamais rien détruire qu'on ne soit sûr de pouvoir remplacer aussi avantageusement " écrivait Plutarque dans ses Œuvres morales du 1er siècle après JC. L'artiste mosaïste Lauren Decamps adhère à cette idée et tente à sa manière de donner une nouvelle vie à ses matériaux en les taillant puis les réassemblant, créant ainsi des œuvres abstraites et figuratives.

  11. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Le Point Isabelle Gailland Du 20 février au 3 mars 2017 CERN Meyrin, Bâtiment principal La Diagonale - Isabelle Gailland. Au départ, un toujours même point minuscule posé au centre de ce que la toile est un espace. Une réplique d'autres points, condensés, alignés, isolés, disséminés construiront dans leur extension, la ligne. Ces lignes, croisées, courbées, déviées, prolongées, seront la structure contenant et séparant la matière des couleurs. La rotation de chaque toile en cours d'exécution va offrir un accès illimité à la non-forme et à la forme. Le point final sera l'ouverture sur différents points de vue de ce que le point et la ligne sont devenus une représentation pour l'œil et l'im...

  12. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    COLORATION Sandra Duchêne From September 5 to 16, 2016 CERN Meyrin, Main Building La recherche de l’Universel. Après tout ! C’est de l’Amour ! What else to say ? …La couleur, l’ENERGIE de la vie…

  13. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Œuvres recentes Fabienne Wyler Du 6 au 17 février 2017 CERN Meyrin, Bâtiment principal L'escalier du diable B - aquarelle, encre de Chine XLV - Fabienne Wyler. En relation avec certains procédés d’écriture contemporaine (par ex. Webern ou certaines musiques conçues par ordinateur), les compositions picturales de Fabienne Wyler s’élaborent à partir de « modules » (groupes de quadrangles) qu’elle reproduit en leur faisant subir toutes sortes de transformations et de déplacements : étirements, renversements, rotations, effet miroir, transpositions, déphasages, superpositions, etc., et ceci à toutes les échelles. Au fil des œuvres sont apparues des séries intitulées, Bifurcations, Intermittences, Attracteurs étranges, Polyrythmies. Ces titres ont un lien &e...

  14. Exhibition

    CERN Multimedia

    Staff Association

    2014-01-01

    Energie sombre, matière noire J.-J. Dalmais - J. Maréchal Du 11 au 27 novembre 2014, CERN Meyrin, Bâtiment principal A l’image des particules atomiques qui ont tissé des liens pour créer la matière, deux artistes haut bugistes croisent leurs regards et conjuguent leurs expressions singulières pour faire naître une vision commune de l’univers, produit des forces primordiales. Les sculptures de Jean-Jacques Dalmais et les peintures de Jacki Maréchal se rencontrent pour la première fois et se racontent par un enrichissement mutuel la belle histoire de la Vie. Dialogue magique des œuvres en mouvement qui questionnent en écho l’énergie sombre et la matière noire. Cette harmonieuse confluence de jeux de miroir et de résonnance illumine de poésie et de sobriété l’espace expos&...

  15. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Harmonie Nathalie Lenoir Du 4 au 15 septembre 2017 CERN Meyrin, Bâtiment principal Peindre est un langage. Le tracé du pinceau sur le lin en est l'expression. A qui appartient un tableau en définitive ? A celui qui l'a peint ? A celui qui le regarde ? A celui qui l'emporte ? La peinture est une émotion partagée... Laissez-vous projeter de l'autre côté de la toile, prenez un moment pour rêver, en harmonie avec les éléments, parce-que la peinture parle à votre âme… Pour plus d’informations et demandes d’accès : staff.association@cern.ch | Tél : 022 766 37 38

  16. Exhibition

    CERN Document Server

    Staff Association

    2017-01-01

    Firmament des toiles Joëlle Lalagüe Du 6 au 16 juin 2017 CERN Meyrin, Bâtiment principal Phylaë Voyage - Joëlle Lalagüe. Each picture is an invitation for a cosmic trip. This is a whispering of soul, which comes from origins. A symphony of the world, some notes of love, a harmony for us to fly to infinity. Pour plus d’informations et demandes d'accès : staff.association@cern.ch | Tél: 022 766 37 38

  17. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    La couleur des jours oriSio Du 2 au 12 mai 2017 CERN Meyrin, Bâtiment principal oriSio - Motus Suite à un fort intérêt pour la Chine et une curiosité pour un médium très ancien, la laque ! Je réinterprète cet art à travers un style abstrait. Je présente ici des laques sur aluminium, travaillés au plasma et ensuite colorés à l’aide de pigments pour l’essentiel. Mes œuvres je les veux brutes, déchirées, évanescentes, gondolées, voire trouées mais avec une belle approche de profondeur de la couleur.   Pour plus d’informations : staff.association@cern.ch | Tél: 022 766 37 38

  18. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    La mosaïque ou quand détruire permet de construire Lauren Decamps Du 28 novembre au 9 décembre 2016 CERN Meyrin, Bâtiment principal Paysage d'Amsterdam - Lauren Decamps On ne doit jamais rien détruire qu'on ne soit sûr de pouvoir remplacer aussi avantageusement " écrivait Plutarque dans ses Œuvres morales du 1er siècle après JC. L'artiste mosaïste Lauren Decamps adhère à cette idée et tente à sa manière de donner une nouvelle vie à ses matériaux en les taillant puis les réassemblant, créant ainsi des œuvres abstraites et figuratives.

  19. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Still Life Jérémy Bajulaz Du 25 septembre au 6 octobre 2017 CERN Meyrin, Main Building (Aubergine - Jérémy Bajulaz) Né en 1991 en Haute-Savoie, France. Diplômé de l'Ecole Emile Cohl à Lyon, Jérémy Bajulaz intègre en 2014 le programme d'artiste en résidence au Centre Genevois de Gravure Contemporaine. C'est là que son travail prendra corps, autour de la lumière et de ses vibrations aux travers de sujets comme le portrait et la nature morte, dans le souci de l'observation; le regard prenant une place importante dans le processus créatif. Lauréat 2017 du VII Premio AAAC, son travail a été présenté dans de nombreuses expositions collectives, en 2015 au Bâtiment d’Art Contemporain de Genève, en 2016 au 89e Salon de Lyon et du S...

  20. An aluminum-based rat model for Alzheimer's disease exhibits oxidative damage, inhibition of PP2A activity, hyperphosphorylated tau, and granulovacuolar degeneration.

    Science.gov (United States)

    Walton, J R

    2007-09-01

    In Alzheimer's disease (AD), oxidative damage leads to the formation of amyloid plaques while low PP2A activity results in hyperphosphorylated tau that polymerizes to form neurofibrillary tangles. We probed these early events, using brain tissue from a rat model for AD that develops memory deterioration and AD-like behaviors in old age after chronically ingesting 1.6 mg aluminum/kg bodyweight/day, equivalent to the high end of the human dietary aluminum range. A control group consumed 0.4 mg aluminum/kg/day. We stained brain sections from the cognitively-damaged rats for evidence of amyloid plaques, neurofibrillary tangles, aluminum, oxidative damage, and hyperphosphorylated tau. PP2A activity levels measured 238.71+/-17.56 pmol P(i)/microg protein and 580.67+/-111.70 pmol P(i)/microg protein (paluminum-loading occurs in some aged rat neurons as in some aged human neurons; (2) aluminum-loading in rat neurons is accompanied by oxidative damage, hyperphosphorylated tau, neuropil threads, and granulovacuolar degeneration; and (3) amyloid plaques and neurofibrillary tangles were absent from all rat brain sections examined. Known species difference can reasonably explain why plaques and tangles are unable to form in brains of genetically-normal rats despite developing the same pathological changes that lead to their formation in human brain. As neuronal aluminum can account for early stages of plaque and tangle formation in an animal model for AD, neuronal aluminum could also initiate plaque and tangle formation in humans with AD.

  1. On the evaluation of box model results: the case of BOXURB model.

    Science.gov (United States)

    Paschalidou, A K; Kassomenos, P A

    2009-08-01

    In the present paper, the BOXURB model results, as they occurred in the Greater Area of Athens after model application on an hourly basis for the 10-year period 1995-2004, are evaluated both in time and space in the light of observed pollutant concentrations time series from 17 monitoring stations. The evaluation is performed at a total, monthly, daily and hourly scale. The analysis also includes evaluation of the model performance with regard to the meteorological parameters. Finally, the model is evaluated as an air quality forecasting and urban planning tool. Given the simplicity of the model and the complexity of the area topography, the model results are found to be in good agreement with the measured pollutant concentrations, especially in the heavy traffic stations. Therefore, the model can be used for regulatory purposes by authorities for time-efficient, simple and reliable estimation of air pollution levels within city boundaries.

  2. Final model independent result of DAMA/LIBRA-phase1

    Energy Technology Data Exchange (ETDEWEB)

    Bernabei, R.; D' Angelo, S.; Di Marco, A. [Universita di Roma ' ' Tor Vergata' ' , Dipartimento di Fisica, Rome (Italy); INFN, sez. Roma ' ' Tor Vergata' ' , Rome (Italy); Belli, P. [INFN, sez. Roma ' ' Tor Vergata' ' , Rome (Italy); Cappella, F.; D' Angelo, A.; Prosperi, D. [Universita di Roma ' ' La Sapienza' ' , Dipartimento di Fisica, Rome (Italy); INFN, sez. Roma, Rome (Italy); Caracciolo, V.; Castellano, S.; Cerulli, R. [INFN, Laboratori Nazionali del Gran Sasso, Assergi (Italy); Dai, C.J.; He, H.L.; Kuang, H.H.; Ma, X.H.; Sheng, X.D.; Wang, R.G. [Chinese Academy, IHEP, Beijing (China); Incicchitti, A. [INFN, sez. Roma, Rome (Italy); Montecchia, F. [INFN, sez. Roma ' ' Tor Vergata' ' , Rome (Italy); Universita di Roma ' ' Tor Vergata' ' , Dipartimento di Ingegneria Civile e Ingegneria Informatica, Rome (Italy); Ye, Z.P. [Chinese Academy, IHEP, Beijing (China); University of Jing Gangshan, Jiangxi (China)

    2013-12-15

    The results obtained with the total exposure of 1.04 ton x yr collected by DAMA/LIBRA-phase1 deep underground at the Gran Sasso National Laboratory (LNGS) of the I.N.F.N. during 7 annual cycles (i.e. adding a further 0.17 ton x yr exposure) are presented. The DAMA/LIBRA-phase1 data give evidence for the presence of Dark Matter (DM) particles in the galactic halo, on the basis of the exploited model independent DM annual modulation signature by using highly radio-pure NaI(Tl) target, at 7.5{sigma} C.L. Including also the first generation DAMA/NaI experiment (cumulative exposure 1.33 ton x yr, corresponding to 14 annual cycles), the C.L. is 9.3{sigma} and the modulation amplitude of the single-hit events in the (2-6) keV energy interval is: (0.0112{+-}0.0012) cpd/kg/keV; the measured phase is (144{+-}7) days and the measured period is (0.998{+-}0.002) yr, values well in agreement with those expected for DM particles. No systematic or side reaction able to mimic the exploited DM signature has been found or suggested by anyone over more than a decade. (orig.)

  3. Infrared thermography for CFRP inspection: computational model and experimental results

    Science.gov (United States)

    Fernandes, Henrique C.; Zhang, Hai; Morioka, Karen; Ibarra-Castanedo, Clemente; López, Fernando; Maldague, Xavier P. V.; Tarpani, José R.

    2016-05-01

    Infrared Thermography (IRT) is a well-known Non-destructive Testing (NDT) technique. In the last decades, it has been widely applied in several fields including inspection of composite materials (CM), specially the fiber-reinforced polymer matrix ones. Consequently, it is important to develop and improve efficient NDT techniques to inspect and assess the quality of CM parts in order to warranty airworthiness and, at the same time, reduce costs of airline companies. In this paper, active IRT is used to inspect carbon fiber-reinforced polymer (CFRP) at laminate with artificial inserts (built-in sample) placed on different layers prior to the manufacture. Two optical active IRT are used. The first is pulsed thermography (PT) which is the most widely utilized IRT technique. The second is a line-scan thermography (LST) technique: a dynamic technique, which can be employed for the inspection of materials by heating a component, line-by-line, while acquiring a series of thermograms with an infrared camera. It is especially suitable for inspection of large parts as well as complex shaped parts. A computational model developed using COMSOL Multiphysics® was used in order to simulate the inspections. Sequences obtained from PT and LST were processed using principal component thermography (PCT) for comparison. Results showed that it is possible to detect insertions of different sizes at different depths using both PT and LST IRT techniques.

  4. An improved Graves' disease model established by using in vivo electroporation exhibited long-term immunity to hyperthyroidism in BALB/c mice.

    Science.gov (United States)

    Kaneda, Toshio; Honda, Asako; Hakozaki, Atsushi; Fuse, Tetsuya; Muto, Akihiro; Yoshida, Tadashi

    2007-05-01

    In Graves' disease, the overstimulation of the thyroid gland and hyperthyroidism are caused by autoantibodies directed against the TSH receptor (TSHR) that mimics the action of TSH. The establishment of an animal model is an important step to study the pathophysiology of autoimmune hyperthyroidism and for immunological analysis. In this study, we adopted the technique of electroporation (EP) for genetic immunization to achieve considerable enhancement of in vivo human TSHR (hTSHR) expression and efficient induction of hyperthyroidism in mice. In a preliminary study using beta-galactosidase (beta-gal) expression vectors, beta-gal introduced into the muscle by EP showed over 40-fold higher enzymatic activity than that introduced via previous direct gene transfer methods. The sustained hTSHR mRNA expression derived from cDNA transferred by EP was detectable in muscle tissue for at least 2 wk by RT-PCR. Based on these results, we induced hyperthyroidism via two expression vectors inserted with hTSHR or hTSHR289His cDNA. Consequently, 12.0-31.8% BALB/c mice immunized with hTSHR and 79.2-95.7% immunized with hTSHR289His showed high total T(4) levels due to the TSHR-stimulating antibody after three to four times repeated immunization by EP, and thyroid follicles of which were hyperplastic and had highly irregular epithelium. Moreover, TSHR-stimulating antibody surprisingly persisted more than 8 months after the last immunization. These results demonstrate that genetic immunization by in vivo EP is more efficient than previous procedures, and that it is useful for delineating the pathophysiology of Graves' disease.

  5. Spin-1 Ising model on tetrahedron recursive lattices: Exact results

    Science.gov (United States)

    Jurčišinová, E.; Jurčišin, M.

    2016-11-01

    We investigate the ferromagnetic spin-1 Ising model on the tetrahedron recursive lattices. An exact solution of the model is found in the framework of which it is shown that the critical temperatures of the second order phase transitions of the model are driven by a single equation simultaneously on all such lattices. It is also shown that this general equation for the critical temperatures is equivalent to the corresponding polynomial equation for the model on the tetrahedron recursive lattice with arbitrary given value of the coordination number. The explicit form of these polynomial equations is shown for the lattices with the coordination numbers z = 6, 9, and 12. In addition, it is shown that the thermodynamic properties of all possible physical phases of the model are also completely driven by the corresponding single equations simultaneously on all tetrahedron recursive lattices. In this respect, the spontaneous magnetization, the free energy, the entropy, and the specific heat of the model are studied in detail.

  6. Droplet Reaction and Evaporation of Agents Model (DREAM). Glass model results; Sand model plans

    NARCIS (Netherlands)

    Hin, A.R.T.

    2006-01-01

    The Agent Fate Program is generating an extensive set of quality agent fate data which is being used to develop highly accurate secondary evaporation predictive models. Models are being developed that cover a wide range of traditional chemical warfare agents deposited onto surfaces routinely found o

  7. Effect of geometry of rice kernels on drying modeling results

    Science.gov (United States)

    Geometry of rice grain is commonly represented by sphere, spheroid or ellipsoid shapes in the drying models. Models using simpler shapes are easy to solve mathematically, however, deviation from the true grain shape might lead to large errors in predictions of drying characteristics such as, moistur...

  8. Urban traffic noise assessment by combining measurement and model results

    NARCIS (Netherlands)

    Eerden, F.J.M. van der; Graafland, F.; Wessels, P.W.; Basten, T.G.H.

    2013-01-01

    A model based monitoring system is applied on a local scale in an urban area to obtain a better understanding of the traffic noise situation. The system consists of a scalable sensor network and an engineering model. A better understanding is needed to take appropriate and cost efficient measures,

  9. Periodic Integration: Further Results on Model Selection and Forecasting

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

    1996-01-01

    textabstractThis paper considers model selection and forecasting issues in two closely related models for nonstationary periodic autoregressive time series [PAR]. Periodically integrated seasonal time series [PIAR] need a periodic differencing filter to remove the stochastic trend. On the other

  10. Results from modeling and simulation of chemical downstream etch systems

    Energy Technology Data Exchange (ETDEWEB)

    Meeks, E.; Vosen, S.R.; Shon, J.W.; Larson, R.S.; Fox, C.A.; Buchenauer

    1996-05-01

    This report summarizes modeling work performed at Sandia in support of Chemical Downstream Etch (CDE) benchmark and tool development programs under a Cooperative Research and Development Agreement (CRADA) with SEMATECH. The Chemical Downstream Etch (CDE) Modeling Project supports SEMATECH Joint Development Projects (JDPs) with Matrix Integrated Systems, Applied Materials, and Astex Corporation in the development of new CDE reactors for wafer cleaning and stripping processes. These dry-etch reactors replace wet-etch steps in microelectronics fabrication, enabling compatibility with other process steps and reducing the use of hazardous chemicals. Models were developed at Sandia to simulate the gas flow, chemistry and transport in CDE reactors. These models address the essential components of the CDE system: a microwave source, a transport tube, a showerhead/gas inlet, and a downstream etch chamber. The models have been used in tandem to determine the evolution of reactive species throughout the system, and to make recommendations for process and tool optimization. A significant part of this task has been in the assembly of a reasonable set of chemical rate constants and species data necessary for successful use of the models. Often the kinetic parameters were uncertain or unknown. For this reason, a significant effort was placed on model validation to obtain industry confidence in the model predictions. Data for model validation were obtained from the Sandia Molecular Beam Mass Spectrometry (MBMS) experiments, from the literature, from the CDE Benchmark Project (also part of the Sandia/SEMATECH CRADA), and from the JDP partners. The validated models were used to evaluate process behavior as a function of microwave-source operating parameters, transport-tube geometry, system pressure, and downstream chamber geometry. In addition, quantitative correlations were developed between CDE tool performance and operation set points.

  11. Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.

    Science.gov (United States)

    Chang, Nai Wen; Tsai, Ming-Hsui; Lin, Chingju; Hsu, Hui Ting; Chu, Pei-Yi; Yeh, Chung-Min; Chiu, Chang-Fang; Yeh, Kun-Tu

    2011-04-01

    The excessive use of areca nut and/or tobacco may induce the production of free radicals and reactive oxygen species, which affect the lipid contents of the cell membrane and are possibly involved in tumorigenic processes in the oral cavity. The aim of this study was to investigate the therapeutic efficacy of fenofibrate (0.1% or 0.3%, w/w), a ligand of the peroxisome proliferator-activated receptor alpha (PPARα), in a 4-nitroquinoline 1-oxide (4-NQO)/arecoline-induced oral cancer mouse model. The carcinogen, 4-NQO/arecoline, was administrated to C57BL/6JNarl mice for 8weeks followed by fenofibrate treatment for 12 or 20weeks. After 28weeks, changes in serum lipids, the multiplicity of tumor lesions, and tumor sizes were determined together with changes in the immunohistochemical expressions of PPARα, acetyl-coenzyme A carboxylase (ACC), the epidermal growth factor receptor (EGFR), and cyclooxygenase-2 (COX2). The results showed that when compared to the 4-NQO/arecoline only group, 0.3% fenofibrate treatment increased serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels. 0.3% fenofibrate treatment suppressed the incidence rate of tongue lesions, reduced the multiplicity of squamous cell carcinoma (SCC), decreased the tumor size, and increased the immunoreactivity of EGFR and COX2 in oral dysplasia but decreased EGFR and COX2 expressions in SCC. These findings indicated that fenofibrate reduced the tumor incidence rate and suppressed the tumor progression into SCC and that these molecular events might be linked to the EGFR and COX2 regulatory pathways. We suggest that fenofibrate provides a new strategy for preventing oral tumor progression. Copyright © 2010 Elsevier B.V. All rights reserved.

  12. Wave-current interactions: model development and preliminary results

    Science.gov (United States)

    Mayet, Clement; Lyard, Florent; Ardhuin, Fabrice

    2013-04-01

    The coastal area concentrates many uses that require integrated management based on diagnostic and predictive tools to understand and anticipate the future of pollution from land or sea, and learn more about natural hazards at sea or activity on the coast. The realistic modelling of coastal hydrodynamics needs to take into account various processes which interact, including tides, surges, and sea state (Wolf [2008]). These processes act at different spatial scales. Unstructured-grid models have shown the ability to satisfy these needs, given that a good mesh resolution criterion is used. We worked on adding a sea state forcing in a hydrodynamic circulation model. The sea state model is the unstructured version of WAVEWATCH III c (Tolman [2008]) (which version is developed at IFREMER, Brest (Ardhuin et al. [2010]) ), and the hydrodynamic model is the 2D barotropic module of the unstructured-grid finite element model T-UGOm (Le Bars et al. [2010]). We chose to use the radiation stress approach (Longuet-Higgins and Stewart [1964]) to represent the effect of surface waves (wind waves and swell) in the barotropic model, as previously done by Mastenbroek et al. [1993]and others. We present here some validation of the model against academic cases : a 2D plane beach (Haas and Warner [2009]) and a simple bathymetric step with analytic solution for waves (Ardhuin et al. [2008]). In a second part we present realistic application in the Ushant Sea during extreme event. References Ardhuin, F., N. Rascle, and K. Belibassakis, Explicit wave-averaged primitive equations using a generalized Lagrangian mean, Ocean Modelling, 20 (1), 35-60, doi:10.1016/j.ocemod.2007.07.001, 2008. Ardhuin, F., et al., Semiempirical Dissipation Source Functions for Ocean Waves. Part I: Definition, Calibration, and Validation, J. Phys. Oceanogr., 40 (9), 1917-1941, doi:10.1175/2010JPO4324.1, 2010. Haas, K. A., and J. C. Warner, Comparing a quasi-3D to a full 3D nearshore circulation model: SHORECIRC and

  13. Box photosynthesis modeling results for WRF/CMAQ LSM

    Data.gov (United States)

    U.S. Environmental Protection Agency — Box Photosynthesis model simulations for latent heat and ozone at 6 different FLUXNET sites. This dataset is associated with the following publication: Ran, L., J....

  14. Review of the dWind Model Conceptual Results

    Energy Technology Data Exchange (ETDEWEB)

    Baring-Gould, Ian; Gleason, Michael; Preus, Robert; Sigrin, Ben

    2015-09-16

    This presentation provides an overview of the dWind model, including its purpose, background, and current status. Baring-Gould presented this material as part of the September 2015 WINDExchange webinar.

  15. Some Econometric Results for the Blanchard-Watson Bubble Model

    DEFF Research Database (Denmark)

    Johansen, Soren; Lange, Theis

    The purpose of the present paper is to analyse a simple bubble model suggested by Blanchard and Watson. The model is defined by y(t) =s(t)¿y(t-1)+e(t), t=1,…,n, where s(t) is an i.i.d. binary variable with p=P(s(t)=1), independent of e(t) i.i.d. with mean zero and finite variance. We take ¿>1 so...

  16. Ex vivo model exhibits protective effects of sesamin against destruction of cartilage induced with a combination of tumor necrosis factor-alpha and oncostatin M.

    Science.gov (United States)

    Khansai, Manatsanan; Boonmaleerat, Kanchanit; Pothacharoen, Peraphan; Phitak, Thanyaluck; Kongtawelert, Prachya

    2016-07-11

    Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammatory arthritis. TNF-α and OSM are pro-inflammatory cytokines that play a key role in RA progression. Thus, reducing the effects of both cytokines is practical in order to relieve the progression of the disease. This current study is interested in sesamin, an active compound in sesame seeds. Sesamin has been shown to be a chondroprotective agent in osteoarthritis models. Here, we have evaluated a porcine cartilage explant as a cartilage degradation model related to RA induced by TNF-α and/or OSM in order to investigate the effects of sesamin on TNF-α and OSM in the cartilage degradation model. A porcine cartilage explant was induced with a combination of TNF-α and OSM (test group) or IL-1β and OSM (control group) followed by a co-treatment of sesamin over a long-term period (35 days). After which, the tested explants were analyzed for indications of both the remaining and the degradation aspects using glycosaminoglycan and collagen as an indicator. The combination of TNF-α and OSM promoted cartilage degradation more than either TNF-α or OSM alone and was comparable with the combination of IL-1β and OSM. Sesamin could be offering protection against cartilage degradation by reducing GAGs and collagen turnover in the generated model. Sesamin might be a promising agent as an alternative treatment for RA patients. Furthermore, the generated model revealed itself to be an impressive test model for the analysis of phytochemical substances against the cartilage degradation model for RA. The model could be used to test for the prevention of cartilage degradation in other biological agents induced with TNF-α and OSM as well.

  17. Results of the 2013 UT modeling benchmark obtained with models implemented in CIVA

    Energy Technology Data Exchange (ETDEWEB)

    Toullelan, Gwénaël; Raillon, Raphaële; Chatillon, Sylvain [CEA, LIST, 91191Gif-sur-Yvette (France); Lonne, Sébastien [EXTENDE, Le Bergson, 15 Avenue Emile Baudot, 91300 MASSY (France)

    2014-02-18

    The 2013 Ultrasonic Testing (UT) modeling benchmark concerns direct echoes from side drilled holes (SDH), flat bottom holes (FBH) and corner echoes from backwall breaking artificial notches inspected with a matrix phased array probe. This communication presents the results obtained with the models implemented in the CIVA software: the pencilmodel is used to compute the field radiated by the probe, the Kirchhoff approximation is applied to predict the response of FBH and notches and the SOV (Separation Of Variables) model is used for the SDH responses. The comparison between simulated and experimental results are presented and discussed.

  18. Preliminary results of a three-dimensional radiative transfer model

    Energy Technology Data Exchange (ETDEWEB)

    O`Hirok, W. [Univ. of California, Santa Barbara, CA (United States)

    1995-09-01

    Clouds act as the primary modulator of the Earth`s radiation at the top of the atmosphere, within the atmospheric column, and at the Earth`s surface. They interact with both shortwave and longwave radiation, but it is primarily in the case of shortwave where most of the uncertainty lies because of the difficulties in treating scattered solar radiation. To understand cloud-radiative interactions, radiative transfer models portray clouds as plane-parallel homogeneous entities to ease the computational physics. Unfortunately, clouds are far from being homogeneous, and large differences between measurement and theory point to a stronger need to understand and model cloud macrophysical properties. In an attempt to better comprehend the role of cloud morphology on the 3-dimensional radiation field, a Monte Carlo model has been developed. This model can simulate broadband shortwave radiation fluxes while incorporating all of the major atmospheric constituents. The model is used to investigate the cloud absorption anomaly where cloud absorption measurements exceed theoretical estimates and to examine the efficacy of ERBE measurements and cloud field experiments. 3 figs.

  19. Reply: New results justify open discussion of alternative models

    Science.gov (United States)

    Newman, Andrew; Stein, Seth; Weber, John; Engeln, Joseph; Mao, Aitlin; Dixon, Timothy

    A millennium ago, Jewish sages wrote that “the rivalry of scholars increases wisdom.” In contrast, Schweig et al. (Eos, this issue) demand that “great caution” be exercised in discussing alternatives to their model of high seismic hazard in the New Madrid seismic zone (NMSZ). We find this view surprising; we have no objection to their and their coworkers' extensive efforts promoting their model in a wide variety of public media, but see no reason not to explore a lower-hazard alternative based on both new data and reanalysis of data previously used to justify their model. In our view, the very purpose of collecting new data and reassessing existing data is to promote spirited testing and improvement of existing hypotheses. For New Madrid, such open reexamination seems scientifically appropriate, given the challenge of understanding intraplate earthquakes, and socially desirable because of the public policy implications.

  20. Some Econometric Results for the Blanchard-Watson Bubble Model

    DEFF Research Database (Denmark)

    Johansen, Soren; Lange, Theis

    The purpose of the present paper is to analyse a simple bubble model suggested by Blanchard and Watson. The model is defined by y(t) =s(t)¿y(t-1)+e(t), t=1,…,n, where s(t) is an i.i.d. binary variable with p=P(s(t)=1), independent of e(t) i.i.d. with mean zero and finite variance. We take ¿>1 so...... is whether a bubble model with infinite variance can create the long swings, or persistence, which are observed in many macro variables. We say that a variable is persistent if its autoregressive coefficient ¿(n) of y(t) on y(t-1), is close to one. We show that the estimator of ¿(n) converges to ¿p...

  1. Transmission resonance Raman spectroscopy: experimental results versus theoretical model calculations.

    Science.gov (United States)

    Gonzálvez, Alicia G; González Ureña, Ángel

    2012-10-01

    A laser spectroscopic technique is described that combines transmission and resonance-enhanced Raman inelastic scattering together with low laser power (view, a model for the Raman signal dependence on the sample thickness is also presented. Essentially, the model considers the sample to be homogeneous and describes the underlying physics using only three parameters: the Raman cross-section, the laser-radiation attenuation cross-section, and the Raman signal attenuation cross-section. The model was applied successfully to describe the sample-size dependence of the Raman signal in both β-carotene standards and carrot roots. The present technique could be useful for direct, fast, and nondestructive investigations in food quality control and analytical or physiological studies of animal and human tissues.

  2. Results on a Binding Neuron Model and Their Implications for Modified Hourglass Model for Neuronal Network

    Directory of Open Access Journals (Sweden)

    Viswanathan Arunachalam

    2013-01-01

    Full Text Available The classical models of single neuron like Hodgkin-Huxley point neuron or leaky integrate and fire neuron assume the influence of postsynaptic potentials to last till the neuron fires. Vidybida (2008 in a refreshing departure has proposed models for binding neurons in which the trace of an input is remembered only for a finite fixed period of time after which it is forgotten. The binding neurons conform to the behaviour of real neurons and are applicable in constructing fast recurrent networks for computer modeling. This paper develops explicitly several useful results for a binding neuron like the firing time distribution and other statistical characteristics. We also discuss the applicability of the developed results in constructing a modified hourglass network model in which there are interconnected neurons with excitatory as well as inhibitory inputs. Limited simulation results of the hourglass network are presented.

  3. Some vaccination strategies for the SEIR epidemic model. Preliminary results

    CERN Document Server

    De la Sen, M; Alonso-Quesada, S

    2011-01-01

    This paper presents a vaccination-based control strategy for a SEIR (susceptible plus infected plus infectious plus removed populations) propagation disease model. The model takes into account the total population amounts as a refrain for the illness transmission since its increase makes more difficult contacts among susceptible and infected. The control objective is the asymptotically tracking of the removed-by-immunity population to the total population while achieving simultaneously the remaining population (i.e. susceptible plus infected plus infectious) to asymptotically tend to zero.

  4. Results from Development of Model Specifications for Multifamily Energy Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Brozyna, K.

    2012-08-01

    Specifications, modeled after CSI MasterFormat, provide the trade contractors and builders with requirements and recommendations on specific building materials, components and industry practices that comply with the expectations and intent of the requirements within the various funding programs associated with a project. The goal is to create a greater level of consistency in execution of energy efficiency retrofits measures across the multiple regions a developer may work. IBACOS and Mercy Housing developed sample model specifications based on a common building construction type that Mercy Housing encounters.

  5. Results From Development of Model Specifications for Multifamily Energy Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Brozyna, Kevin [IBACOS, Inc., Pittsburgh, PA (United States)

    2012-08-01

    Specifications, modeled after CSI MasterFormat, provide the trade contractors and builders with requirements and recommendations on specific building materials, components and industry practices that comply with the expectations and intent of the requirements within the various funding programs associated with a project. The goal is to create a greater level of consistency in execution of energy efficiency retrofits measures across the multiple regions a developer may work. IBACOS and Mercy Housing developed sample model specifications based on a common building construction type that Mercy Housing encounters.

  6. Some Results On The Modelling Of TSS Manufacturing Lines

    Directory of Open Access Journals (Sweden)

    Viorel MÎNZU

    2000-12-01

    Full Text Available This paper deals with the modelling of a particular class of manufacturing lines, governed by a decentralised control strategy so that they balance themselves. Such lines are known as “bucket brigades” and also as “TSS lines”, after their first implementation, at Toyota, in the 70’s. A first study of their behaviour was based upon modelling as stochastic dynamic systems, which emphasised, in the frame of the so-called “Normative Model”, a sufficient condition for self-balancing, that means for autonomous functioning at a steady production rate (stationary behaviour. Under some particular conditions, a simulation analysis of TSS lines could be made on non-linear block diagrams, showing that the state trajectories are piecewise continuous in between occurrences of certain discrete events, which determine their discontinuity. TSS lines may therefore be modelled as hybrid dynamic systems, more specific, with autonomous switching and autonomous impulses (jumps. A stability analysis of such manufacturing lines is allowed by modelling them as hybrid dynamic systems with discontinuous motions.

  7. How modeling can reconcile apparently discrepant experimental results: the case of pacemaking in dopaminergic neurons.

    Directory of Open Access Journals (Sweden)

    Guillaume Drion

    2011-05-01

    Full Text Available Midbrain dopaminergic neurons are endowed with endogenous slow pacemaking properties. In recent years, many different groups have studied the basis for this phenomenon, often with conflicting conclusions. In particular, the role of a slowly-inactivating L-type calcium channel in the depolarizing phase between spikes is controversial, and the analysis of slow oscillatory potential (SOP recordings during the blockade of sodium channels has led to conflicting conclusions. Based on a minimal model of a dopaminergic neuron, our analysis suggests that the same experimental protocol may lead to drastically different observations in almost identical neurons. For example, complete L-type calcium channel blockade eliminates spontaneous firing or has almost no effect in two neurons differing by less than 1% in their maximal sodium conductance. The same prediction can be reproduced in a state of the art detailed model of a dopaminergic neuron. Some of these predictions are confirmed experimentally using single-cell recordings in brain slices. Our minimal model exhibits SOPs when sodium channels are blocked, these SOPs being uncorrelated with the spiking activity, as has been shown experimentally. We also show that block of a specific conductance (in this case, the SK conductance can have a different effect on these two oscillatory behaviors (pacemaking and SOPs, despite the fact that they have the same initiating mechanism. These results highlight the fact that computational approaches, besides their well known confirmatory and predictive interests in neurophysiology, may also be useful to resolve apparent discrepancies between experimental results.

  8. 基于web的汽车弹簧三维模型的展示与交互%Exhibition and Interaction of Three-dimensional Lightweight Automobile Spring Model Based on Web

    Institute of Scientific and Technical Information of China (English)

    王天鹏; 朱文华; 张梦之

    2011-01-01

    The exhibition and interaction of the three-dimensional model can always build a vivid atmosphere for the viewers, it can improve the efficiency of the products designing, However, when the product owns a large sums of parts, the size of the data for the simulation expands greatly, which will make it inconvenient for the sharing and publishing and can only be viewed locally. In view of this situation, the exhibition and interaction of the three-dimensional lightweight model was proposed based on the internet, and the three dimensional lightweight files were used which was produced by Mockup. Through this way, it is very easy for the engineers and customers to view it, also they can immediately modify the model by the feedback of the customers and broaden the distribution channel. This kind of technology has been applied to the automobile spring, and the results prove to be effective.%三维模型的展示和交互往往能给人一种逼真的效果,能够提高产品设计的效率。然而当产品的零部件个数很多时,模型文件将十分巨大,不便于网络共享与发布,而仅限于本地浏览。鉴于这种情况,提出基于网络的三维轻量化模型的展示与交互,岁产应用Mockup软件生成三雏轻量化JT仿真文件,这样便于工程师与客户的查看,同时能够根据客户的反馈,进行即时的更改,同时也扩展了产品的销售渠道。把这种技术应用于汽车弹簧,取得了预期的效果。

  9. Regionalization of climate model results for the North Sea

    Energy Technology Data Exchange (ETDEWEB)

    Kauker, F. [Alfred-Wegener-Institut fuer Polar- und Meeresforschung, Bremerhaven (Germany); Storch, H. von [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Hydrophysik

    2000-07-01

    A dynamical downscaling for the North Sea is presented. The numerical model used for the study is the coupled ice-ocean model OPYC. In a hindcast of the years 1979 to 1993 it was forced with atmospheric forcing of the ECMWF reanalysis. The models capability in simulating the observed mean state and variability in the North Sea is demonstrated by the hindcast. Two time scale ranges, from weekly to seasonal and the longer-than-seasonal time scales are investigated. Shorter time scales, for storm surges, are not captured by the model formulation. The main modes of variability of sea level, sea-surface circulation, sea-surface temperature, and sea-surface salinity are described and connections to atmospheric phenomena, like the NAO, are discussed. T106 ''time-slice'' simulations with a ''2 x CO{sub 2}'' horizon are used to estimate the effects of a changing climate on the shelf sea ''North Sea''. The ''2 x CO{sub 2}'' changes in the surface forcing are accompanied by changes in the lateral oceanic boundary conditions taken from a global coupled climate model. For ''2 x CO{sub 2}'' the time mean sea level increases up to 25 cm in the German Bight in the winter, where 15 cm are due to the surface forcing and 10 cm due to thermal expansion. This change is compared to the ''natural'' variability as simulated in the ECMWF integration and found to be not outside the range spanned by it. The variability of sea level on the weekly-to-seasonal time-scales is significantly reduced in the scenario integration. The variability on the longer-than-seasonal time-scales in the control and scenario runs is much smaller then in the ECMWF integration. This is traced back to the use of ''time-slice'' experiments. Discriminating between locally forced changes and changes induced at the lateral oceanic boundaries of the model in the circulation and

  10. Science Fiction Exhibits as STEM Gateways

    Science.gov (United States)

    Robie, Samantha

    Women continue to hold less than a quarter of all STEM jobs in the United States, prompting many museums to develop programs and exhibits with the express goal of interesting young girls in scientific fields. At the same time, a number of recent museum exhibits have harnessed the popularity of pop culture and science fiction in order to interest general audiences in STEM subject matter, as well as using the exhibits as springboards to expand or shift mission goals and focus. Because science fiction appears to be successful at raising interest in STEM fields, it may be an effective way to garner the interest of young girls in STEM in particular. This research seeks to describe the ways in which museums are currently using science fiction exhibits to interest young girls in STEM fields and careers. Research focused on four institutions across the country hosting three separate exhibits, and included staff interviews and content analysis of exhibit descriptions, promotional materials, a summative evaluation and supplementary exhibit productions. In some ways, science fiction exhibits do serve young girls, primarily through the inclusion of female role models, staff awareness, and prototype testing to ensure interactives are attractive to girls as well as to boys. However, STEM appears to be underutilized, which may be partly due to a concern within the field that the outcome of targeting a specific gender could be construed as "stereotyping".

  11. The World of Virtual Exhibitions

    Directory of Open Access Journals (Sweden)

    Irena Eiselt

    2013-09-01

    Full Text Available EXTENDED ABSTRACTSpecial collections of the National and University Library (NUK hide a lot of items of precious value. The Slovenian cultural heritage is stored on paper or on other media as a part of the library’s Manuscripts, Incunabula and Rare Books Collection, Old Prints Collection, Maps and Pictorial Collection, Music Collection, Ephemera Collection, Serials Collection, and Slovenian Diaspora Publications Collection. Only a small part of the treasures is temporary revealed to the public on special exhibitions. The idea of virtual exhibitions of library treasures was born in 2005. The library aimed to exhibit precious items of special collections of high historical or artistic value. In 2008 the first two virtual exhibitions were created in-house offering access to the rich collections of old postcards of Ljubljana at the beginning of 20th century kept in the Maps and Pictorial Collection of NUK. They were soon followed by other virtual exhibitions. At the beginning they were organised in the same way as physical exhibitions, afterwards different programs were used for creation of special effects (for ex. 3D wall. About two years ago it was decided that the creation of virtual exhibitions will be simplified. Files of digitised and borndigital library materials in jpg format are imported to MS PowerPoint 2010. Each jpg file is now formatted by adding a frame, a description … to the slides which are saved as jpg files. The last step is the import of jpg files into Cooliris application used for NUK web exhibitions. In the paper the virtual exhibition design and creation, the technical point of view and criteria for the selection of exhibition content are explained following the example of the virtual exhibitions the Old Postcards of Ljubljana, Photo Ateliers in Slovenia, a collection of photographs Four Seasons by Fran Krašovec and photos of Post-Earthquake Ljubljana in 1895.

  12. A Dissipative Model for Hydrogen Storage: Existence and Regularity Results

    CERN Document Server

    Chiodaroli, Elisabetta

    2010-01-01

    We prove global existence of a solution to an initial and boundary value problem for a highly nonlinear PDE system. The problem arises from a termomechanical dissipative model describing hydrogen storage by use of metal hydrides. In order to treat the model from an analytical point of view, we formulate it as a phase transition phenomenon thanks to the introduction of a suitable phase variable. Continuum mechanics laws lead to an evolutionary problem involving three state variables: the temperature, the phase parameter and the pressure. The problem thus consists of three coupled partial differential equations combined with initial and boundary conditions. Existence and regularity of the solutions are here investigated by means of a time discretization-a priori estimate-passage to the limit procedure joined with compactness and monotonicity arguments.

  13. Vaccination strategies for SEIR models using feedback linearization. Preliminary results

    CERN Document Server

    De la Sen, M; Alonso-Quesada, S

    2011-01-01

    A linearization-based feedback-control strategy for a SEIR epidemic model is discussed. The vaccination objective is the asymptotically tracking of the removed-by-immunity population to the total population while achieving simultaneously the remaining population (i.e. susceptible plus infected plus infectious) to asymptotically tend to zero. The disease controlpolicy is designed based on a feedback linearization technique which provides a general method to generate families of vaccination policies with sound technical background.

  14. Recent results in the NJL model with heavy quarks

    CERN Document Server

    Feldmann, T

    1996-01-01

    We investigate the interplay of chiral and heavy quark symmetries by using the NJL quark model. Heavy quarks with finite masses m(Q) as well as the limit m(Q) to infinity are studied. We found large corrections to the heavy mass scaling law for the pseudoscalar decay constant. The influence of external momenta on the shape parameters of the Isgur-Wise form factor is discussed.

  15. Blade element momentum modeling of inflow with shear in comparison with advanced model results

    DEFF Research Database (Denmark)

    Aagaard Madsen, Helge; Riziotis, V.; Zahle, Frederik

    2012-01-01

    There seems to be a significant uncertainty in aerodynamic and aeroelastic simulations on megawatt turbines operating in inflow with considerable shear, in particular with the engineering blade element momentum (BEM) model, commonly implemented in the aeroelastic design codes used by industry....... Computations with advanced vortex and computational fluid dynamics models are used to provide improved insight into the complex flow phenomena and rotor aerodynamics caused by the sheared inflow. One consistent result from the advanced models is the variation of induced velocity as a function of azimuth when...... a higher power than in uniform flow. On the basis of the consistent azimuthal induction variations seen in the advanced model results, three different BEM implementation methods are discussed and tested in the same aeroelastic code. A full local BEM implementation on an elemental stream tube in both...

  16. The physical model of a terraced plot: first results

    Science.gov (United States)

    Perlotto, Chiara; D'Agostino, Vincenzo; Buzzanca, Giacomo

    2017-04-01

    Terrace building have been expanded in the 19th century because of the increased demographic pressure and the need to crop additional areas at steeper slopes. Terraces are also important to regulate the hydrological behavior of the hillslope. Few studies are available in literature on rainfall-runoff processes and flood risk mitigation in terraced areas. Bench terraces, reducing the terrain slope and the length of the overland flow, quantitatively control the runoff flow velocity, facilitating the drainage and thus leading to a reduction of soil erosion. The study of the hydrologic-hydraulic function of terraced slopes is essential in order to evaluate their possible use to cooperate for flood-risk mitigation also preserving the landscape value. This research aims to better focus the times of the hydrological response, which are determined by a hillslope plot bounded by a dry-stone wall, considering both the overland flow and the groundwater. A physical model, characterized by a quasi-real scale, has been built to reproduce the behavior of a 3% outward sloped terrace at bare soil condition. The model consists of a steel metal box (1 m large, 3.3 m long, 2 m high) containing the hillslope terrain. The terrain is equipped with two piezometers, 9 TDR sensors measuring the volumetric water content, a surface spillway at the head releasing the steady discharge under test, a scale at the wall base to measure the outflowing discharge. The experiments deal with different initial moisture condition (non-saturated and saturated), and discharges of 19.5, 12.0 and 5.0 l/min. Each experiment has been replicated, conducting a total number of 12 tests. The volumetric water content analysis produced by the 9 TDR sensors was able to provide a quite satisfactory representation of the soil moisture during the runs. Then, different lag times at the outlet since the inflow initiation were measured both for runoff and groundwater. Moreover, the time of depletion and the piezometer

  17. Experimentally constrained CA1 fast-firing parvalbumin-positive interneuron network models exhibit sharp transitions into coherent high frequency rhythms

    Directory of Open Access Journals (Sweden)

    Katie A Ferguson

    2013-10-01

    Full Text Available The coupling of high frequency oscillations (HFOs; >100 Hz and theta oscillations (3-12 Hz in the CA1 region of rats increases during REM sleep, indicating that it may play a role in memory processing. However, it is unclear whether the CA1 region itself is capable of providing major contributions to the generation of HFOs, or if they are strictly driven through input projections. Parvalbumin-positive (PV+ interneurons may play an essential role in these oscillations due to their extensive connections with neighbouring pyramidal cells, and their characteristic fast-spiking. Thus, we created mathematical network models to investigate the conditions under which networks of CA1 fast-spiking PV+ interneurons are capable of producing high frequency population rhythms.We used whole-cell patch clamp recordings of fast-spiking, PV+ cells in the CA1 region of an intact hippocampal preparation in vitro to derive cellular properties, from which we constrained an Izhikevich-type model. Novel, biologically constrained network models were constructed with these individual cell models, and we investigated networks across a range of experimentally determined excitatory inputs and inhibitory synaptic strengths. For each network, we determined network frequency and coherence.Network simulations produce coherent firing at high frequencies (> 90 Hz for parameter ranges in which PV-PV inhibitory synaptic conductances are necessarily small and external excitatory inputs are relatively large. Interestingly, our networks produce sharp transitions between random and coherent firing, and this sharpness is lost when connectivity is increased beyond biological estimates. Our work suggests that CA1 networks may be designed with mechanisms for quickly gating in and out of high frequency coherent population rhythms, which may be essential in the generation of nested theta/high frequency rhythms.

  18. Reaction and Diffusion of Cementitious Water in Bentonite: Results of `Blind' Modelling

    Science.gov (United States)

    Watson, C.; Hane, K.; Savage, D.; Benbow, S.; Cuevas, J.; Fernandez, R.

    2009-04-01

    The potential deleterious geochemical interactions of clay with cement/concrete may provide a constraint on the use of the latter material in deep geological disposal facilities for radioactive wastes. Consequently, it is important to have a fundamental understanding of these interactions to be able to assess their likely impact over the long timescales appropriate to the isolation of radioactive wastes from the human environment. Here, a laboratory experiment investigating the effects of cementitious water diffusing through bentonite has been simulated using a coupled reactive-transport geochemical modelling code. The modelling study was carried out before the results of the experiments were available, as an exercise in ‘blind' modelling. A sensitivity study was carried out to investigate uncertainties associated with a number of input parameters, such as the precise nature of kinetic and ion-exchange reactions, diffusion coefficients, pore water composition, and montmorillonite dissolution models. The experiments used two types of fluid; one saturated with calcium hydroxide showed little mineralogical alteration, which was predicted by the computer simulations. A high pH K-Na-OH-based water however, caused alteration (pore blocking by hydrotalcite, gibbsite and brucite growth) to a depth of 2 mm in the bentonite after a period of 1 year. Experimental evidence showed that ion exchange of Mg-montmorillonite to K-montmorillonite was not confined to this thin region however, and was found to extend throughout the whole of the bentonite sample. The pore blocking by mineral precipitation and movement of ion exchange fronts through the bentonite were accurately simulated by the model. The choice of dissolution model for montmorillonite played an important role in the outcome of the simulations. Of the cases considered in the sensitivity study, that employing the so-called ‘Yamaguchi model' was clearly the best match, exhibiting all the main characteristics of the

  19. Modelling nitrogen and phosphorus cycles and dissolved oxygen in the Zhujiang Estuary Ⅱ. Model results

    Institute of Scientific and Technical Information of China (English)

    Guan Weibing; Wong Lai-Ah; Xu Dongfeng

    2001-01-01

    In the present study, the ecosystem-based water quality model was applied to the Pearl River (Zhujiang) Estuary. The model results successfully represent the distribution trend of nutrients and dissolved oxygen both in the horizontal and vertical planes during the flood season, and it shows that the model has taken into consideration the key part of the dynamical, chemical and biological processes existing in the Zhujiang Estuary. The further studies illustrate that nitrogen is in plenty while phosphorus and light limit the phytoplankton biomass in the Zhujiang Estuary during the flood season.

  20. Exact results in modeling planetary atmospheres-III

    Energy Technology Data Exchange (ETDEWEB)

    Pelkowski, J. [Institut fuer Atmosphaere und Umwelt, J.W. Goethe Universitaet Frankfurt, Campus Riedberg, Altenhoferallee 1, D-60438 Frankfurt a.M. (Germany)], E-mail: Pelkowski@meteor.uni-frankfurt.de; Chevallier, L. [Observatoire de Paris-Meudon, Laboratoire LUTH, 5 Place Jules Janssen, 92195 Meudon cedex (France); Rutily, B. [Universite de Lyon, F-69003 Lyon (France); Universite Lyon 1, Observatoire de Lyon, 9 avenue Charles Andre, F-69230 Saint-Genis-Laval (France); CNRS, UMR 5574, Centre de Recherche Astrophysique de Lyon (France); Ecole Normale Superieure de Lyon, F-69007 Lyon (France); Titaud, O. [Centro de Modelamiento Matematico, UMI 2807 CNRS-UChile, Blanco Encalada 2120 - 7 Piso, Casilla 170 - Correo 3, Santiago (Chile)

    2008-01-15

    We apply the semi-gray model of our previous paper to the particular case of the Earth's atmosphere, in order to illustrate quantitatively the inverse problem associated with the direct problem we dealt with before. From given climatological values of the atmosphere's spherical albedo and transmittance for visible radiation, the single-scattering albedo and the optical thickness in the visible are inferred, while the infrared optical thickness is deduced for given global average surface temperature. Eventually, temperature distributions in terms of the infrared optical depth will be shown for a terrestrial atmosphere assumed to be semi-gray and, locally, in radiative and thermodynamic equilibrium.

  1. Exact results in modeling planetary atmospheres-I. Gray atmospheres

    Energy Technology Data Exchange (ETDEWEB)

    Chevallier, L. [Observatoire de Paris-Meudon, Laboratoire LUTH, 5 Place Jules Janssen, 92195 Meudon cedex (France)]. E-mail: loic.chevallier@obspm.fr; Pelkowski, J. [Institut fuer Meteorologie und Geophysik, J.W. Goethe Universitaet Frankfurt, Robert Mayer Strasse 1, D-60325 Frankfurt (Germany); Rutily, B. [Universite de Lyon, Lyon, F-69000 (France) and Universite Lyon 1, Villeurbanne, F-69622 (France) and Centre de Recherche Astronomique de Lyon, Observatoire de Lyon, 9 avenue Charles Andre, Saint-Genis Laval cedex, F-69561 (France) and CNRS, UMR 5574; Ecole Normale Superieure de Lyon, Lyon (France)

    2007-04-15

    An exact model is proposed for a gray, isotropically scattering planetary atmosphere in radiative equilibrium. The slab is illuminated on one side by a collimated beam and is bounded on the other side by an emitting and partially reflecting ground. We provide expressions for the incident and reflected fluxes on both boundary surfaces, as well as the temperature of the ground and the temperature distribution in the atmosphere, assuming the latter to be in local thermodynamic equilibrium. Tables and curves of the temperature distribution are included for various values of the optical thickness. Finally, semi-infinite atmospheres illuminated from the outside or by sources at infinity is dealt with.

  2. Delta-tilde interpretation of standard linear mixed model results

    DEFF Research Database (Denmark)

    Brockhoff, Per Bruun; Amorim, Isabel de Sousa; Kuznetsova, Alexandra

    2016-01-01

    effects relative to the residual error and to choose the proper effect size measure. For multi-attribute bar plots of F-statistics this amounts, in balanced settings, to a simple transformation of the bar heights to get them transformed into depicting what can be seen as approximately the average pairwise...... for factors with differences in number of levels. For mixed models, where in general the relevant error terms for the fixed effects are not the pure residual error, it is suggested to base the d-prime-like interpretation on the residual error. The methods are illustrated on a multifactorial sensory profile...... inherently challenging effect size measure estimates in ANOVA settings....

  3. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr.

    Science.gov (United States)

    Lloyd, David J; McCormick, Jocelyn; Helmering, Joan; Kim, Ki Won; Wang, Minghan; Fordstrom, Preston; Kaufman, Stephen A; Lindberg, Richard A; Véniant, Murielle M

    2008-03-01

    The metabolic syndrome is a group of disorders including obesity, insulin resistance, atherogenic dyslipidemia, hyperglycemia, and hypertension. To date, few animal models have been described to recapitulate the phenotypes of the syndrome. In this study, we generated and characterized two lines of triple-knockout mice that are deficient in either apolipoprotein E (Apoe(-/-)) or low-density lipoprotein receptor (Ldlr(-/-)) and express no leptin (Lep(ob/ob)) or apolipoprotein B-48 but exclusively apolipoprotein B-100 (Apob(100/100)). These two lines are referred to as Apoe triple-knockout-Apoe 3KO (Apoe(-/-)Apob(100/100)Lep(ob/ob)) and Ldlr triple-knockout-Ldlr 3KO (Ldlr(-/-)Apob(100/100)Lep(ob/ob)) mice. Both lines develop obesity, hyperinsulinemia, hyperlipidemia, hypertension, and atherosclerosis. However, only Apoe 3KO mice are hyperglycemic and glucose intolerant and are more obese than Ldlr 3KO mice. To evaluate the utility of these lines as pharmacological models, we treated both with leptin and found that leptin therapy ameliorated most metabolic derangements. Leptin was more effective in improving glucose tolerance in Ldlr 3KO than Apoe 3KO animals. The reduction of plasma cholesterol by leptin in Ldlr 3KO mice can be accounted for by its suppressive effect on food intake. However, in Apoe 3KO mice, leptin further reduced plasma cholesterol independently of its effect on food intake, and this improvement correlated with a smaller plaque lesion area. These effects suggest a direct role of leptin in modulating VLDL levels and, likewise, the lesion areas in VLDL-enriched animals. These two lines of mice represent new models with features of the metabolic syndrome and will be useful in testing therapies targeted for combating the human condition.

  4. VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease.

    Directory of Open Access Journals (Sweden)

    Mallikarjun Badadani

    Full Text Available Dominant mutations in the valosin containing protein (VCP gene cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD. We have generated a knock-in mouse model with the common R155H mutation. Mice demonstrate progressive muscle weakness starting approximately at the age of 6 months. Histology of mutant muscle showed progressive vacuolization of myofibrils and centrally located nuclei, and immunostaining shows progressive cytoplasmic accumulation of TDP-43 and ubiquitin-positive inclusion bodies in quadriceps myofibrils and brain. Increased LC3-II staining of muscle sections representing increased number of autophagosomes suggested impaired autophagy. Increased apoptosis was demonstrated by elevated caspase-3 activity and increased TUNEL-positive nuclei. X-ray microtomography (uCT images show radiolucency of distal femurs and proximal tibiae in knock-in mice and uCT morphometrics shows decreased trabecular pattern and increased cortical wall thickness. Bone histology and bone marrow derived macrophage cultures in these mice revealed increased osteoclastogenesis observed by TRAP staining suggestive of Paget bone disease. The VCP(R155H/+ knock-in mice replicate the muscle, bone and brain pathology of inclusion body myopathy, thus representing a useful model for preclinical studies.

  5. The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space.

    Science.gov (United States)

    Ahmadi, Mahboubeh; Dufour, Jean-Philippe; Seifritz, Erich; Mirnajafi-Zadeh, Javad; Saab, Bechara J

    2017-07-14

    Recurrent seizures that define epilepsy are often accompanied by psychosocial problems and cognitive deficits with incompletely understood aetiology. We therefore used the pentylenetetrazol (PTZ) kindling model of epilepsy in mice to examine potential seizure-associated neuropathologies, focusing on motivation, memory and novel-environment-induced activation of midbrain dopaminergic neurons. In addition to recurrent seizures, we found that PTZ kindling led to a strong suppression of novelty-driven exploration while largely sparing fear-driven exploration. The deficits in exploratory drive may be relevant for other cognitive impairments since reduced unassisted rearing in a learning arena correlated with poorer spatial memory of object location. Using c-Fos immunofluorescence as a marker of neuronal activity, we observed that dopamine neurons within the ventral tegmental area (VTA) of PTZ kindled mice demonstrate hyperactivity at baseline and hypoactivity in response to a novel environment compared to saline-injected cagemate controls. These data extend previous findings of PTZ kindling-mediated disruptions of hippocampal processes important for novel environment recognition and learning by demonstrating PTZ kindling also induces motivational deficits that are associated with reduced stimulus-evoked activation of VTA dopamine neurons. More broadly, these data help understand the aetiology of complex behavioural changes in the PTZ kindling model, and may assist in the development of superior diagnoses and treatments for epilepsy. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Large Deviation Results for Generalized Compound Negative Binomial Risk Models

    Institute of Scientific and Technical Information of China (English)

    Fan-chao Kong; Chen Shen

    2009-01-01

    In this paper we extend and improve some results of the large deviation for random sums of random variables.Let {Xn;n≥1} be a sequence of non-negative,independent and identically distributed random variables with common heavy-tailed distribution function F and finite mean μ∈R+,{N(n);n≥0} be a sequence of negative binomial distributed random variables with a parameter p ∈(0,1),n≥0,let {M(n);n≥0} be a Poisson process with intensity λ0.Suppose {N(n);n≥0},{Xn;n≥1} and {M(n);n≥0} are mutually results.These results can be applied to certain problems in insurance and finance.

  7. Theoretical Modeling of ISO Results on Planetary Nebula NGC 7027

    Science.gov (United States)

    Yan, M.; Federman, S. R.; Dalgarno, A.; Bjorkman, J. E.

    1999-04-01

    We present a thermal and chemical model of the neutral envelope of planetary nebula NGC 7027. In our model, the neutral envelope is composed of a thin dense shell of constant density and an outer stellar wind region with the usual inverse-square law density profile. The thermal and chemical structure is calculated with the assumption that the incident radiation field on the inner surface equals 0.5×105 times Draine's fit to the average interstellar far-ultraviolet field. The rate coefficient for H2 formation on grains is assumed to be 1/5 the usual value to take into account the lower dust-gas mass ratio in the neutral envelope of NGC 7027. The calculated temperature in the dense shell decreases from 3000 to under 200 K. Once the temperature drops to 200 K, we assume that it remains at 200 K until the outer edge of the dense shell is reached, so that the observed intensities of CO J=16-15, 15-14, and 14-13 lines can be reproduced. The 200 K temperature can be interpreted as the average temperature of the shocked gas just behind the forward shock front in the framework of the interacting stellar wind theory. We calculate the intensities of the molecular far-infrared rotational lines by using a revised version of the escape probability formalism. The theoretical intensities for rotational lines of CO (from J=29-28 to J=14-13), CH+, OH, and CH are shown to be in good agreement with ISO observations. The H2 rovibrational line intensities are also calculated and are in agreement with available observations.

  8. Combining forming results via weld models to powerful numerical assemblies

    NARCIS (Netherlands)

    Kose, K.; Rietman, Bert

    2004-01-01

    Forming simulations generally give satisfying results with respect to thinning, stresses, changed material properties and, with a proper springback calculation, the geometric form. The joining of parts by means of welding yields an extra change of the material properties and the residual stresses.

  9. Combining forming results via weld models to powerful numerical assemblies

    NARCIS (Netherlands)

    Kose, K.; Rietman, B.

    2004-01-01

    Forming simulations generally give satisfying results with respect to thinning, stresses, changed material properties and, with a proper springback calculation, the geometric form. The joining of parts by means of welding yields an extra change of the material properties and the residual stresses. W

  10. A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

    Science.gov (United States)

    Wasan, Ellen K; Gershkovich, Pavel; Zhao, Jinying; Zhu, Xiaohua; Werbovetz, Karl; Tidwell, Richard R; Clement, John G; Thornton, Sheila J; Wasan, Kishor M

    2010-12-07

    To develop an oral formulation of amphotericin B (AmB) that is stable at the temperatures of WHO Climatic Zones 3 and 4 (30-43 °C) and to evaluate its efficacy in a murine model of visceral leishmaniasis (VL). The stability testing of four novel oral lipid AmB formulations composed of mono- and di-glycerides and pegylated esters (iCo-010 to iCo-013) was performed over 60 d and analyzed by HPLC-UV. In addition, the four formulations were incubated 4 h in fasted-state simulated intestinal fluid. AmB concentration was measured spectrophotometrically and emulsion droplet diameter was assessed by dynamic light scattering. Antileishmanial activity of iCo-010 was evaluated at increasing oral doses (2.5 to 10 mg/kg) in a murine model of VL. AmB stability in the lipid formulation (iCo-010) was >75% over 60 days. After 4 h in fasted-state simulated intestinal fluid, AmB concentration was >95%. iCo-010 demonstrated significant efficacy when orally administered to VL-infected mice bid for five days (inhibition of 99%, 98%, and 83% at 10, 5 and 2.5 mg/kg compared to the vehicle control). In addition, the qd dose of 20 mg/kg provided 96% inhibition compared to the vehicle control. The oral AmB formulation iCo-010 is stable at the temperatures of WHO Climatic Zones 3 and 4 (30-43 °C). iCo-010 showed excellent antileishmanial activity at both 10 mg/kg po bid for 5 days (<99% reduction in parasitic infection) and 20 mg/kg po qd for 5 days (95% inhibition when compared to control).

  11. ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety.

    Science.gov (United States)

    Partyka, Anna; Wasik, Anna; Jastrzębska-Więsek, Magdalena; Mierzejewski, Paweł; Bieńkowski, Przemysław; Kołaczkowski, Marcin; Wesołowska, Anna

    2016-06-01

    Behavioral and psychological symptoms of dementia (BPSD) include apathy, sleep problems, irritability, wandering, elation, agitation/aggression, and mood disorders such as depression and/or anxiety. Elderly patients are usually treated with second-generation antipsychotics; however, they present not enough efficacy against all symptoms observed. Hence, there still is an unmet need for novel pharmacotherapeutic agents targeted BPSD. A novel arylsulfonamide derivative ADN-1184 has been developed that possesses a preclinical profile of activity corresponding to criteria required for treatment of both psychosis and depressive symptoms of BPSD without exacerbating cognitive impairment or inducing motor disturbances. To broaden its pharmacological efficacy toward anxiety symptoms, its anxiolytic properties have been examined in common animal preclinical models in rats and mice. ADN-1184 significantly increased the number of entries into open arms measured in the elevated plus-maze test; however, it simultaneously increased parameters of exploratory activity. In the Vogel conflict drinking test, ADN-1184 dose-dependently and significantly increased the number of shocks accepted and the number of licks. Moreover, in mice, it also had specific anxiolytic-like activity in the four-plate test, and only negligible one at a specific mid-range dose measured in the spontaneous marble burying test. The obtained findings reveal that ADN-1184 displays anxiolytic-like activity in animal models of anxiety which employed punished stimuli. In its unusual combination of some anxiolytic action with already proven antipsychotic and antidepressant properties, and lack of any disruptive impact on learning and memory processes and motor coordination, ADN-1184 displays a profile that would be desired for a novel therapeutic for BPSD.

  12. Ionospheric Poynting Flux and Joule Heating Modeling Challenge: Latest Results and New Models.

    Science.gov (United States)

    Shim, J. S.; Rastaetter, L.; Kuznetsova, M. M.; Knipp, D. J.; Zheng, Y.; Cosgrove, R. B.; Newell, P. T.; Weimer, D. R.; Fuller-Rowell, T. J.; Wang, W.

    2014-12-01

    Poynting Flux and Joule Heating in the ionosphere - latest results from the challenge and updates at the CCMC. With the addition of satellite tracking and display features in the online analysis tool and at the Community Coordinated Modeling Center (CCMC), we are now able to obtain Poynting flux and Joule heating values from a wide variety of ionospheric models. In addition to Poynting fluxes derived from electric and magnetic field measurements from the Defense Meteorological Satellite Program (DMSP) satellites for a recent modeling challenge, we can now use a Poynting Flux model derived from FAST satellite observations for comparison. Poynting Fluxes are also correlated using Ovation Prime maps of precipitation patterns during the same time periods to assess how "typical" the events in the challenge are.

  13. Modeling Framework and Results to Inform Charging Infrastructure Investments

    Energy Technology Data Exchange (ETDEWEB)

    Melaina, Marc W [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Wood, Eric W [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-01

    The plug-in electric vehicle (PEV) market is experiencing rapid growth with dozens of battery electric (BEV) and plug-in hybrid electric (PHEV) models already available and billions of dollars being invested by automotive manufacturers in the PEV space. Electric range is increasing thanks to larger and more advanced batteries and significant infrastructure investments are being made to enable higher power fast charging. Costs are falling and PEVs are becoming more competitive with conventional vehicles. Moreover, new technologies such as connectivity and automation hold the promise of enhancing the value proposition of PEVs. This presentation outlines a suite of projects funded by the U.S. Department of Energy's Vehicle Technology Office to conduct assessments of the economic value and charging infrastructure requirements of the evolving PEV market. Individual assessments include national evaluations of PEV economic value (assuming 73M PEVs on the road in 2035), national analysis of charging infrastructure requirements (with community and corridor level resolution), and case studies of PEV ownership in Columbus, OH and Massachusetts.

  14. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model.

    Science.gov (United States)

    Yoo, Ki Hyun; Park, Jong-Hwa; Lee, Dae Young; Hwang-Bo, Jeon; Baek, Nam In; Chung, In Sik

    2015-05-01

    We describe the anti-angiogenic and anti-lymphangiogenic effects of corosolic acid, a pentacyclic triterpenoid isolated from Cornus kousa Burg. A mouse colon carcinoma CT-26 animal model was employed to determine the in vivo anti-angiogenic and anti-lymphangiogenic effects of corosolic acid. Corosolic acid induced apoptosis in CT-26 cells, mediated by the activation of caspase-3. In addition, it reduced the final tumor volume and the blood and lymphatic vessel densities of tumors, indicating that it suppresses in vivo angiogenesis and lymphangiogenesis. Corosolic acid inhibited the proliferation and tube formation of human umbilical vein endothelial cells and human dermal lymphatic microvascular endothelial cells. In addition, corosolic acid decreased the proliferation and migration of human umbilical vein endothelial cells stimulated by angiopoietin-1. Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1.

  15. Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model

    Science.gov (United States)

    Karunanidhi, Arunkumar; Jeevajothi Nathan, Jayakayatri; van Belkum, Alex

    2017-01-01

    The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice burn model infected with methicillin-resistant Staphylococcus aureus (MRSA). Hexane (ASHE) and dichloromethane (ASDE) extracts were tested. Female BALB/c mice were inflicted with third-degree thermal injury followed by infection with MRSA. ASHE and ASDE formulated with simple ointment base (SOB) at concentrations of 1%, 2%, and 5% (w/w) were topically applied to burn wounds twice a day for 20 days. Silver sulfadiazine (1%) served as drug positive control. Microbiological analysis was carried out on 1, 2, 3, 4, and 5 days postwounding (dpw) and histopathological analysis at the end of the experiment (20 dpw). Both ointments demonstrated strong antibacterial activity with complete elimination of MRSA at 48–72 h after infection. The rate of wound contraction was higher (95–100%) in mice groups treated with ASHE and ASDE ointments after 15 dpw. Histological analysis revealed significant increase (p antibacterial as well as promising alternatives in managing thermal injuries. PMID:28321262

  16. Standard Model Higgs results from ATLAS and CMS experiments

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00221190; The ATLAS collaboration

    2016-01-01

    The properties of the Higgs boson particle were measured with the ATLAS and CMS experiments at the LHC at the centre-of-mass energies 7 TeV and 8 TeV. The combined data samples of the ATLAS and CMS experiments were used for the measurements of the Higgs boson mass and couplings. Furthermore, the CP and spin analysis done separately with the CMS and ATLAS experiments are described. Moreover, first results of the Higgs boson cross section at the centre-of-mass energy 13 TeV in the channels H->ZZ->4leptons and H->gamma+gamma with the ATLAS detector are presented.

  17. Auto Technology Exhibition in Tianjing

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ The 4th International Automotive Technology Exhibition Tianjing2009,jointly hosted by the Society of Automotive Engineers of China(SAE-China),China Automotive Technology and Research Center(CATRC)and Tianjin Economic-Technological Development Area(TETD),is to be held in Tianjin Binhai International Convention and Exhibition Center from August 27 to August 30 this year.In line with China's national 11th Five-year Plan,The Automobile Industry Revitalization and Adjustments Planning and The Equipment Manufacturing Revitalization and Adjustments Planning,this Exhibition,centered on the theme of automobile and equipment manufacturing,arranges the exhibition halls respectively for private autos,commercial autos and equipment manufacturing etc.

  18. Photowalk Exhibition opens at Microcosm

    CERN Document Server

    Katarina Anthony

    2011-01-01

    The winning photographs from the 2010 Global Particle Physics Photowalk competition will go on display at Microcosm from 11 February to 2 April. The exhibition is part of a global photography event taking place over three continents, with Photowalk exhibitions opening simultaneously at Fermilab in the US, KEK in Japan and here at CERN.   DESY wire chamber - First place people's choice; second place global jury competition. Photographer: Hans-Peter Hildebrandt  If you were one of the 1,300 photography lovers who voted in last year’s Photowalk competition, this exhibition is your chance to see the winning entries in print. The exhibition will take place in the downstairs gallery of Microcosm, overlooking the garden. 15 photographs will be on display, with each of the laboratories that participated in Photowalk represented by their 3 winning entries. Among them will be the “people’s choice” sunburst photo of a particle detector at DESY (Photo 1), and...

  19. High Quality Virtual Reality for Architectural Exhibitions

    DEFF Research Database (Denmark)

    Kreutzberg, Anette

    2016-01-01

    This paper will summarise the findings from creating and implementing a visually high quality Virtual Reality (VR) experiment as part of an international architecture exhibition. It was the aim to represent the architectural spatial qualities as well as the atmosphere created from combining natural...... and artificial lighting in a prominent not yet built project. The outcome is twofold: Findings concerning the integration of VR in an exhibition space and findings concerning the experience of the virtual space itself. In the exhibition, an important aspect was the unmanned exhibition space, requiring the VR...... experience to be self-explanatory. Observations of different visitor reactions to the unmanned VR experience compared with visitor reactions at guided tours with personal instructions are evaluated. Data on perception of realism, spatial quality and light in the VR model were collected with qualitative...

  20. A δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity.

    Directory of Open Access Journals (Sweden)

    Stefan Schneider

    Full Text Available Besides transketolase (TKT, a thiamin-dependent enzyme of the pentose phosphate pathway, the human genome encodes for two closely related transketolase-like proteins, which share a high sequence identity with TKT. Transketolase-like protein 1 (TKTL1 has been implicated in cancerogenesis as its cellular expression levels were reported to directly correlate with invasion efficiency of cancer cells and patient mortality. It has been proposed that TKTL1 exerts its function by catalyzing an unusual enzymatic reaction, a hypothesis that has been the subject of recent controversy. The most striking difference between TKTL1 and TKT is a deletion of 38 consecutive amino acids in the N-terminal domain of the former, which constitute part of the active site in authentic TKT. Our structural and sequence analysis suggested that TKTL1 might not possess transketolase activity. In order to test this hypothesis in the absence of a recombinant expression system for TKTL1 and resilient data on its biochemical properties, we have engineered and biochemically characterized a "pseudo-TKTL1" Δ38 deletion variant of human TKT (TKTΔ38 as a viable model of TKTL1. Although the isolated protein is properly folded under in vitro conditions, both thermal stability as well as stability of the TKT-specific homodimeric assembly are markedly reduced. Circular dichroism and NMR spectroscopic analysis further indicates that TKTΔ38 is unable to bind the thiamin cofactor in a specific manner, even at superphysiological concentrations. No transketolase activity of TKTΔ38 can be detected for conversion of physiological sugar substrates thus arguing against an intrinsically encoded enzymatic function of TKTL1 in tumor cell metabolism.

  1. Collagen Extracted from Persian Gulf Squid Exhibits Anti-Cytotoxic Properties on Apple Pectic Treated Cells: Assessment in an In Vitro Bioassay Model

    Directory of Open Access Journals (Sweden)

    Ladan DELPHI

    2016-10-01

    Full Text Available Background: Collagen-based three-dimensional (3D in vitro systems have been introduced to study the physiological states of cells. As a biomolecule, collagen is usually extracted from terrestrial animals whilst aquatic animals like squid contain large amounts of collagen.Methods: In order to make effective use of marine organisms, we selected Persian Gulf squid in 2015 to extract the required collagen. Then, a 3D culture system based on the extracted collagen was applied to investigate cellular mechanisms in a native microenvironment. The formed collagen gel was used to investigate the growth of MDA-MB-231 breast cancer cells as well as responses to pectic acid.Results: The results revealed that the extracted collagen contained α, ß and γ components with high water holding capacity. This collagen formed a gel-like structure, which could promote the proliferation of MDA-MB-231 breast cancer cells. The MDA-MB-231 cells’ viability in presence of pectic acid, demonstrating the cells’ behavior in a 3D culture system. Conclusion: It seems that the collagen extracted from squid skin has type I collagen properties. It might be used as a substrate in 3D cell culture systems. Keywords: Cell culture, Collagen, Pectic acid, Squid, 3D culture system 

  2. Stress Resultant Based Elasto-Viscoplastic Thick Shell Model

    Directory of Open Access Journals (Sweden)

    Pawel Woelke

    2012-01-01

    Full Text Available The current paper presents enhancement introduced to the elasto-viscoplastic shell formulation, which serves as a theoretical base for the finite element code EPSA (Elasto-Plastic Shell Analysis [1–3]. The shell equations used in EPSA are modified to account for transverse shear deformation, which is important in the analysis of thick plates and shells, as well as composite laminates. Transverse shear forces calculated from transverse shear strains are introduced into a rate-dependent yield function, which is similar to Iliushin's yield surface expressed in terms of stress resultants and stress couples [12]. The hardening rule defined by Bieniek and Funaro [4], which allows for representation of the Bauschinger effect on a moment-curvature plane, was previously adopted in EPSA and is used here in the same form. Viscoplastic strain rates are calculated, taking into account the transverse shears. Only non-layered shells are considered in this work.

  3. High-energy radiation damage in zirconia: modeling results

    Energy Technology Data Exchange (ETDEWEB)

    Zarkadoula, Eva; Devanathan, Ram; Weber, William J.; Seaton, Michael; Todorov, Ilian; Nordlund, Kai; Dove, Martin T.; Trachenko, Kostya

    2014-02-28

    Zirconia has been viewed as a material of exceptional resistance to amorphization by radiation damage, and was consequently proposed as a candidate to immobilize nuclear waste and serve as a nuclear fuel matrix. Here, we perform molecular dynamics simulations of radiation damage in zirconia in the range of 0.1-0.5 MeV energies with the account of electronic energy losses. We find that the lack of amorphizability co-exists with a large number of point defects and their clusters. These, importantly, are largely disjoint from each other and therefore represent a dilute damage that does not result in the loss of long-range structural coherence and amorphization. We document the nature of these defects in detail, including their sizes, distribution and morphology, and discuss practical implications of using zirconia in intense radiation environments.

  4. High-energy radiation damage in zirconia: modeling results

    Energy Technology Data Exchange (ETDEWEB)

    Zarkadoula, Evangelia [Queen Mary, University of London; Devanathan, Ram [Pacific Northwest National Laboratory (PNNL); Weber, William J [ORNL; Seaton, M [Daresbury Laboratory, UK; Todorov, I T [Daresbury Laboratory, UK; Nordlund, Kai [University of Helsinki; Dove, Martin T [Queen Mary, University of London; Trachenko, Kostya [Queen Mary, University of London

    2014-01-01

    Zirconia is viewed as a material of exceptional resistance to amorphization by radiation damage, and consequently proposed as a candidate to immobilize nuclear waste and serve as an inert nuclear fuel matrix. Here, we perform molecular dynamics simulations of radiation damage in zirconia in the range of 0.1-0.5 MeV energies with account of electronic energy losses. We nd that the lack of amorphizability co-exists with a large number of point defects and their clusters. These, importantly, are largely isolated from each other and therefore represent a dilute damage that does not result in the loss of long-range structural coherence and amorphization. We document the nature of these defects in detail, including their sizes, distribution and morphology, and discuss practical implications of using zirconia in intense radiation environments.

  5. High-energy radiation damage in zirconia: Modeling results

    Energy Technology Data Exchange (ETDEWEB)

    Zarkadoula, E., E-mail: zarkadoulae@ornl.gov [School of Physics and Astronomy, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); SEPnet, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 (United States); Devanathan, R. [Nuclear Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352 (United States); Weber, W. J. [Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 (United States); Department of Materials Science and Engineering, University of Tennessee, Knoxville, Tennessee 37996 (United States); Seaton, M. A.; Todorov, I. T. [STFC Daresbury Laboratory, Scientific Computing Department, Keckwick Lane, Daresbury, Warrington, Cheshire WA4 4AD (United Kingdom); Nordlund, K. [University of Helsinki, P.O. Box 43, FIN-00014 Helsinki (Finland); Dove, M. T. [School of Physics and Astronomy, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); Trachenko, K. [School of Physics and Astronomy, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); SEPnet, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom)

    2014-02-28

    Zirconia is viewed as a material of exceptional resistance to amorphization by radiation damage, and consequently proposed as a candidate to immobilize nuclear waste and serve as an inert nuclear fuel matrix. Here, we perform molecular dynamics simulations of radiation damage in zirconia in the range of 0.1–0.5 MeV energies with account of electronic energy losses. We find that the lack of amorphizability co-exists with a large number of point defects and their clusters. These, importantly, are largely isolated from each other and therefore represent a dilute damage that does not result in the loss of long-range structural coherence and amorphization. We document the nature of these defects in detail, including their sizes, distribution, and morphology, and discuss practical implications of using zirconia in intense radiation environments.

  6. Globe exhibit wins international acclaim

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    The Globe’s “Universe of Particles” exhibition has recently received four prestigious awards for its avant-garde design. This external praise is great encouragement for the CERN exhibitions currently on the drawing board.   The Universe of Particles exhibition has won 4 awards for its avant-garde design. Back in 2008, the design company Atelier Brückner was presented with a challenge: to design the layout of a new permanent exhibition for CERN, one that would epitomize both the Organization and its research. The brief was concise but complex: the exhibit had to be symbolic of the Organization, use modern technology, engage and immerse visitors, and, preferably, use touch-screen technology. With the help of IArt, an interactive technology firm, and based on the content provided by CERN’s Education Group, Atelier Brückner developed the “Universe of Particles” exhibit as it is today. Its principal concept centred on the s...

  7. Greenhouse Earth: A Traveling Exhibition

    Energy Technology Data Exchange (ETDEWEB)

    Booth, W.H.; Caesar, S.

    1992-09-01

    The Franklin Institute Science Museum provided an exhibit entitled the Greenhouse Earth: A Traveling Exhibition. This 3500 square-foot exhibit on global climate change was developed in collaboration with the Association of Science-Technology Centers. The exhibit opened at The Franklin Institute on February 14, 1992, welcoming 291,000 visitors over its three-month stay. During its three-year tour, Greenhouse Earth will travel to ten US cities, reaching two million visitors. Greenhouse Earth aims to deepen public understanding of the scientific issues of global warming and the conservation measures that can be taken to slow its effects. The exhibit features hands-on exhibitry, interactive computer programs and videos, a theater production, a demonstration cart,'' guided tours, and lectures. supplemental educational programs at the Institute included a teachers preview, a symposium on climate change, and a satellite field trip.'' The development of Greenhouse Earth included front-end and formative evaluation procedures. Evaluation includes interviews with visitors, prototypes, and summative surveys for participating museums. During its stay in Philadelphia, Greenhouse Earth was covered by the local and national press, with reviews in print and broadcast media. Greenhouse Earth is the first large-scale museum exhibit to address global climate change.

  8. First results from the International Urban Energy Balance Model Comparison: Model Complexity

    Science.gov (United States)

    Blackett, M.; Grimmond, S.; Best, M.

    2009-04-01

    A great variety of urban energy balance models has been developed. These vary in complexity from simple schemes that represent the city as a slab, through those which model various facets (i.e. road, walls and roof) to more complex urban forms (including street canyons with intersections) and features (such as vegetation cover and anthropogenic heat fluxes). Some schemes also incorporate detailed representations of momentum and energy fluxes distributed throughout various layers of the urban canopy layer. The models each differ in the parameters they require to describe the site and the in demands they make on computational processing power. Many of these models have been evaluated using observational datasets but to date, no controlled comparisons have been conducted. Urban surface energy balance models provide a means to predict the energy exchange processes which influence factors such as urban temperature, humidity, atmospheric stability and winds. These all need to be modelled accurately to capture features such as the urban heat island effect and to provide key information for dispersion and air quality modelling. A comparison of the various models available will assist in improving current and future models and will assist in formulating research priorities for future observational campaigns within urban areas. In this presentation we will summarise the initial results of this international urban energy balance model comparison. In particular, the relative performance of the models involved will be compared based on their degree of complexity. These results will inform us on ways in which we can improve the modelling of air quality within, and climate impacts of, global megacities. The methodology employed in conducting this comparison followed that used in PILPS (the Project for Intercomparison of Land-Surface Parameterization Schemes) which is also endorsed by the GEWEX Global Land Atmosphere System Study (GLASS) panel. In all cases, models were run

  9. PICASSO VISION instrument design, engineering model test results, and flight model development status

    Science.gov (United States)

    Näsilä, Antti; Holmlund, Christer; Mannila, Rami; Näkki, Ismo; Ojanen, Harri J.; Akujärvi, Altti; Saari, Heikki; Fussen, Didier; Pieroux, Didier; Demoulin, Philippe

    2016-10-01

    PICASSO - A PICo-satellite for Atmospheric and Space Science Observations is an ESA project led by the Belgian Institute for Space Aeronomy, in collaboration with VTT Technical Research Centre of Finland Ltd, Clyde Space Ltd. (UK) and Centre Spatial de Liège (BE). The test campaign for the engineering model of the PICASSO VISION instrument, a miniaturized nanosatellite spectral imager, has been successfully completed. The test results look very promising. The proto-flight model of VISION has also been successfully integrated and it is waiting for the final integration to the satellite platform.

  10. Modelling combustion reactions for gas flaring and its resulting emissions

    Directory of Open Access Journals (Sweden)

    O. Saheed Ismail

    2016-07-01

    Full Text Available Flaring of associated petroleum gas is an age long environmental concern which remains unabated. Flaring of gas maybe a very efficient combustion process especially steam/air assisted flare and more economical than utilization in some oil fields. However, it has serious implications for the environment. This study considered different reaction types and operating conditions for gas flaring. Six combustion equations were generated using the mass balance concept with varying air and combustion efficiency. These equations were coded with a computer program using 12 natural gas samples of different chemical composition and origin to predict the pattern of emission species from gas flaring. The effect of key parameters on the emission output is also shown. CO2, CO, NO, NO2 and SO2 are the anticipated non-hydrocarbon emissions of environmental concern. Results show that the quantity and pattern of these chemical species depended on percentage excess/deficiency of stoichiometric air, natural gas type, reaction type, carbon mass content, impurities, combustion efficiency of the flare system etc. These emissions degrade the environment and human life, so knowing the emission types, pattern and flaring conditions that this study predicts is of paramount importance to governments, environmental agencies and the oil and gas industry.

  11. Modelling of a water plasma flow: I. Basic results

    Energy Technology Data Exchange (ETDEWEB)

    KotalIk, Pavel [INP Greifswald, Friedrich-Ludwig-Jahn-Strasse 19, 17489 Greifswald (Germany)

    2006-06-21

    One-fluid MHD equations are numerically solved for an axisymmetric flow of thermal water plasma inside and outside a discharge chamber of a plasma torch with water vortex stabilization of electric arc. Comparisons with experimental data and previous calculations are given. For arc currents of 300-600 A, the respective temperatures and velocities in the range 16 700-26 400 K and 2300-6900 m s{sup -1} are obtained at the centre of the nozzle exit. The flow velocity on axis increases by 1-2 km s{sup -1} in the 5 mm long nozzle. Ohmic heating and radiative losses are two competitive processes influencing most the plasma temperature and velocity. The radiative losses represent 39% to 46% of the torch power of 69-174 kW when optical thickness of 3 mm is assumed for the plasma column. In front of the cathode, inside the discharge chamber, a recirculation zone is predicted and discussed. Effects of the temperature dependence of the plasma viscosity and sound velocity and of the optical thickness are examined. It is shown that the results such as waviness of the Mach number isolines are direct consequences of these dependences. Different lengths of 55 and 60 mm of the water vortex stabilized part of the electric arc do not substantially influence the plasma temperature and velocity at the nozzle exit.

  12. Interannual sedimentary effluxes of alkalinity in the southern North Sea: Model results compared with summer observations.

    Science.gov (United States)

    Paetsch, Johannes; Kuehn, Wilfried; Six, Katharina

    2016-04-01

    Alkalinity generation in the sediment of the southern North Sea is the focus of several recent studies. One motivation for these efforts is the potentially enhanced buffering capacity of anthropogenic CO2 invasion into the corresponding pelagic system. An adaptation of a global multilayer sediment model (Heinze et al., 1999) in combination with a pelagic ecosystem model for shelf sea dynamics was used to study the benthic reactions on very different annual cycles (2001 - 2009) including the River Elbe summer flooding in 2002. The focus of this study is the efflux of alkalinity, their different contributors (aerobic respiration, denitrification, net sulfate reduction, calcite dissolution, nitrification) and their seasonal and interannual cycles. Similar to the observations covering the southern North Sea (Brenner et al., 2015) the model results show large horizontal gradients from the near-shore high productive areas with benthic remineralization up to Rmin = 10.6 mol C m-2 yr-1 and TA generation RTA = 2 mol C m-2 yr-1 to off-shore moderate productive areas with mean Rmin = 2.5 mol C m-2 yr-1 and mean TA generation RTA = 0.4 mol C m-2 yr-1. Beside calcite dissolution, aerobic respiration (producing ammonium) and denitrification are the largest contributors to alkalinity generation. Nitrification is reducing alkalinity in the sediment. Due to low regenerated primary production in summer, the year 2001 exhibits the lowest input of particulate organic matter into the sediment (POCexp=2.3 mol C m-2 yr-1), while the year 2003 exhibits the highest export production (POCexp=2.6 mol C m-2 yr-1). The biogeochemical reactions and the effluxes from the sediment follow these pelagic amplitudes with a time lag of about one year with damped amplitudes. References Brenner, H., Braeckman, U., Le Guitton, M., Meysman, F.J.R., 2015. The impact of sedimentary alkalinity release on the water column CO2 system in the North Sea. Biogeosiences Discussion, 12(15): 12395-12453. Heinze, C

  13. Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets.

    Science.gov (United States)

    Sun, Honglei; Pu, Juan; Wei, Yandi; Sun, Yipeng; Hu, Jiao; Liu, Litao; Xu, Guanlong; Gao, Weihua; Li, Chong; Zhang, Xuxiao; Huang, Yinhua; Chang, Kin-Chow; Liu, Xiufan; Liu, Jinhua

    2016-07-15

    Since May 2014, highly pathogenic avian influenza H5N6 virus has been reported to cause six severe human infections three of which were fatal. The biological properties of this subtype, in particular its relative pathogenicity and transmissibility in mammals, are not known. We characterized the virus receptor-binding affinity, pathogenicity, and transmissibility in mice and ferrets of four H5N6 isolates derived from waterfowl in China from 2013-2014. All four H5N6 viruses have acquired a binding affinity for human-like SAα2,6Gal-linked receptor to be able to attach to human tracheal epithelial and alveolar cells. The emergent H5N6 viruses, which share high sequence similarity with the human isolate A/Guangzhou/39715/2014 (H5N6), were fully infective and highly transmissible by direct contact in ferrets but showed less-severe pathogenicity than the parental H5N1 virus. The present results highlight the threat of emergent H5N6 viruses to poultry and human health and the need to closely track their continual adaptation in humans. Extended epizootics and panzootics of H5N1 viruses have led to the emergence of the novel 2.3.4.4 clade of H5 virus subtypes, including H5N2, H5N6, and H5N8 reassortants. Avian H5N6 viruses from this clade have caused three fatalities out of six severe human infections in China since the first case in 2014. However, the biological properties of this subtype, especially the pathogenicity and transmission in mammals, are not known. Here, we found that natural avian H5N6 viruses have acquired a high affinity for human-type virus receptor. Compared to the parental clade 2.3.4 H5N1 virus, emergent H5N6 isolates showed less severe pathogenicity in mice and ferrets but acquired efficient in-contact transmission in ferrets. These findings suggest that the threat of avian H5N6 viruses to humans should not be ignored. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  14. Error statistics of hidden Markov model and hidden Boltzmann model results

    Directory of Open Access Journals (Sweden)

    Newberg Lee A

    2009-07-01

    Full Text Available Abstract Background Hidden Markov models and hidden Boltzmann models are employed in computational biology and a variety of other scientific fields for a variety of analyses of sequential data. Whether the associated algorithms are used to compute an actual probability or, more generally, an odds ratio or some other score, a frequent requirement is that the error statistics of a given score be known. What is the chance that random data would achieve that score or better? What is the chance that a real signal would achieve a given score threshold? Results Here we present a novel general approach to estimating these false positive and true positive rates that is significantly more efficient than are existing general approaches. We validate the technique via an implementation within the HMMER 3.0 package, which scans DNA or protein sequence databases for patterns of interest, using a profile-HMM. Conclusion The new approach is faster than general naïve sampling approaches, and more general than other current approaches. It provides an efficient mechanism by which to estimate error statistics for hidden Markov model and hidden Boltzmann model results.

  15. Error statistics of hidden Markov model and hidden Boltzmann model results

    Science.gov (United States)

    Newberg, Lee A

    2009-01-01

    Background Hidden Markov models and hidden Boltzmann models are employed in computational biology and a variety of other scientific fields for a variety of analyses of sequential data. Whether the associated algorithms are used to compute an actual probability or, more generally, an odds ratio or some other score, a frequent requirement is that the error statistics of a given score be known. What is the chance that random data would achieve that score or better? What is the chance that a real signal would achieve a given score threshold? Results Here we present a novel general approach to estimating these false positive and true positive rates that is significantly more efficient than are existing general approaches. We validate the technique via an implementation within the HMMER 3.0 package, which scans DNA or protein sequence databases for patterns of interest, using a profile-HMM. Conclusion The new approach is faster than general naïve sampling approaches, and more general than other current approaches. It provides an efficient mechanism by which to estimate error statistics for hidden Markov model and hidden Boltzmann model results. PMID:19589158

  16. Implementing the Simple Biosphere Model (SiB) in a general circulation model: Methodologies and results

    Science.gov (United States)

    Sato, N.; Sellers, P. J.; Randall, D. A.; Schneider, E. K.; Shukla, J.; Kinter, J. L., III; Hou, Y.-T.; Albertazzi, E.

    1989-01-01

    The Simple Biosphere MOdel (SiB) of Sellers et al., (1986) was designed to simulate the interactions between the Earth's land surface and the atmosphere by treating the vegetation explicitly and relistically, thereby incorporating biophysical controls on the exchanges of radiation, momentum, sensible and latent heat between the two systems. The steps taken to implement SiB in a modified version of the National Meteorological Center's spectral GCM are described. The coupled model (SiB-GCM) was used with a conventional hydrological model (Ctl-GCM) to produce summer and winter simulations. The same GCM was used with a conventional hydrological model (Ctl-GCM) to produce comparable 'control' summer and winter variations. It was found that SiB-GCM produced a more realistic partitioning of energy at the land surface than Ctl-GCM. Generally, SiB-GCM produced more sensible heat flux and less latent heat flux over vegetated land than did Ctl-GCM and this resulted in the development of a much deeper daytime planetary boundary and reduced precipitation rates over the continents in SiB-GCM. In the summer simulation, the 200 mb jet stream and the wind speed at 850 mb were slightly weakened in the SiB-GCM relative to the Ctl-GCM results and equivalent analyses from observations.

  17. Dental pulp-derived stromal cells exhibit a higher osteogenic potency than bone marrow-derived stromal cells in vitro and in a porcine critical-size bone defect model

    Directory of Open Access Journals (Sweden)

    Jensen Jonas

    2016-01-01

    Full Text Available Introduction: The osteogenic differentiation of bone marrow-derived mesenchymal stromal cells (BMSCs was compared with that of dental pulp-derived stromal cells (DPSCs in vitro and in a pig calvaria critical-size bone defect model. Methods: BMSCs and DPSCs were extracted from the tibia bone marrow and the molar teeth of each pig, respectively. BMSCs and DPSCs were cultured in monolayer and on a three-dimensional (3D polycaprolactone (PCL – hyaluronic acid – tricalcium phosphate (HT-PCL scaffold. Population doubling (PD, alkaline phosphatase (ALP activity, and calcium deposition were measured in monolayer. In the 3D culture ALP activity, DNA content, and calcium deposition were evaluated. Six non-penetrating critical-size defects were made in each calvarium of 14 pigs. Three paired sub-studies were conducted: (1 empty defects vs. HT-PCL scaffolds; (2 PCL scaffolds vs. HT-PCL scaffolds; and (3 autologous BMSCs on HT-PCL scaffolds vs. autologous DPSCs on HT-PCL scaffolds. The observation time was five weeks. Bone volume fractions (BV/TV were assessed with micro-computed tomography (μCT and histomorphometry. Results and discussion: The results from the in vitro study revealed a higher ALP activity and calcium deposition of the DPSC cultures compared with BMSC cultures. Significantly more bone was present in the HT-PCL group than in both the pure PCL scaffold group and the empty defect group in vivo. DPSCs generated more bone than BMSCs when seeded on HT-PCL. In conclusion, DPSCs exhibited a higher osteogenic potential compared with BMSCs both in vitro and in vivo, making it a potential cell source for future bone tissue engineering.

  18. Exhibition - Mathematics, A Beautiful Elsewhere

    CERN Multimedia

    2011-01-01

    From 21 October 2011 to 18 March 2012, the Fondation Cartier pour l’art contemporain will present the exhibition Mathematics: A Beautiful Elsewhere, an exhibition developed in association with the Institut des Hautes Études Scientifiques (IHÉS) and under the patronage of UNESCO. For this unprecedented event, the foundation invited mathematicians to work with artists with whom it has previously worked to create an exhibition that allows visitors to see, hear, do, interpret and think about mathematics. By bringing mathematics into its premises, the Fondation Cartier is itself undergoing the “sudden change of scenery” described by mathematician Alexandre Grothendieck. More information is available here. Fondation Cartier pour l’art contemporain 261, boulevard Raspail 75014 Paris http://fondation.cartier.com Private Visit For professors, researchers and all the staff of Mathematics departments...

  19. The response of an equatorial ocean to simple wind stress patterns. I - Model formulation and analytic results. II - Numerical results

    Science.gov (United States)

    Cane, M. A.

    1979-01-01

    A time-dependent, primitive equation, beta plane model that is two-dimensional in the horizontal has been developed to model wind-driven equatorial ocean circulation. A simple vertical structure consisting of two layers above the thermocline with the same constant density permits a steady-state undercurrent in the model. An analytical study of the linear dynamics of the model suggests that the addition of inertial effects is needed to simulate the undercurrent properly. Also, both linear and nonlinear dynamics of the model are investigated numerically. Such nonlinear response to wind stress as a strong eastward equatorial undercurrent and an intense eastward 'countercurrent' at three deg N are noted in the numerical results.

  20. 18 CFR 50.7 - Applications: exhibits.

    Science.gov (United States)

    2010-04-01

    ... data that represent system operating conditions. (i) Exhibit I—Project Cost and Financing. (1) A statement of estimated costs of any new construction or modification. (2) The estimated capital cost and...) Provide all files to model normal, single contingency, multiple contingency, and special...

  1. Reaching the Public through Traveling Exhibitions

    Science.gov (United States)

    Dusenbery, P. B.; Harold, J. B.; Morrow, C. A.

    2004-11-01

    The Space Science Institute (SSI) of Boulder, Colorado has recently developed two museum exhibits called Alien Earths and MarsQuest. It has just started to develop another exhibit called Giant Planets. These exhibitions provide research scientists the opportunity to engage in a number of activities that are vital to the success of these major outreach programs. Alien Earths was developed in partnership with various research missions. The focus of the presentation will be on MarsQuest and Giant Planets. MarsQuest is a 5000 square-foot, \\$3M, traveling exhibition that is now touring the country. The exhibit's second 3-year tour will enable millions of Americans to share in the excitement of the scientific exploration of Mars and learn more about their own planet in the process. The associated planetarium show and education program will also be described, with particular emphasis on workshops to orient museum staff (e.g. museum educators and docents) and workshops for master educators near host museums and science centers. The workshops make innovative connections between the exhibition's interactive experiences and lesson plans aligned with the National Science Education Standards. These exhibit programs are good models for actively involving scientists and their discoveries to help improve informal science education in the museum community and for forging a stronger connection between formal and informal education. The presentation will also discuss how Giant Planets, a proposed 3500 square-foot traveling exhibition on the mysteries and discoveries of the outer planets, will be able to take advantage of the connections and resources that have been developed by the MarsQuest project.

  2. Discrete Element Modeling Results of Proppant Rearrangement in the Cooke Conductivity Cell

    Energy Technology Data Exchange (ETDEWEB)

    Earl Mattson; Hai Huang; Michael Conway; Lisa O' Connell

    2014-02-01

    mechanical interactions subjected to an applied stress, where the experimental cell is represented as a cohesive body composed of a large number of discrete elements, and proppants can be modeled as the individual discrete particles with various sizes (following the proppant size distribution-density function used in the test) that exhibit no cohesive strength between the particles. Initial 2-D DEM modeling results suggest that proppant rearrangement and non-uniform stress distribution across the proppant pack results in significant non-uniform porosity distribution across the Cooke cell. Larger porosities develop along the edge of the proppant pack beneath the square ring seal and would result in a disproportionate higher flow field along these edges as compared to the middle of the proppant pack. These results suggest that reported conductivity values determined by the Cooke cell may be biased to overestimate the actual conductivity of the proppant at high stresses and that modifications to the standard Cooke cell will affect the magnitude of this bias.

  3. Higher plant modelling for life support applications: first results of a simple mechanistic model

    Science.gov (United States)

    Hezard, Pauline; Dussap, Claude-Gilles; Sasidharan L, Swathy

    2012-07-01

    In the case of closed ecological life support systems, the air and water regeneration and food production are performed using microorganisms and higher plants. Wheat, rice, soybean, lettuce, tomato or other types of eatable annual plants produce fresh food while recycling CO2 into breathable oxygen. Additionally, they evaporate a large quantity of water, which can be condensed and used as potable water. This shows that recycling functions of air revitalization and food production are completely linked. Consequently, the control of a growth chamber for higher plant production has to be performed with efficient mechanistic models, in order to ensure a realistic prediction of plant behaviour, water and gas recycling whatever the environmental conditions. Purely mechanistic models of plant production in controlled environments are not available yet. This is the reason why new models must be developed and validated. This work concerns the design and test of a simplified version of a mathematical model coupling plant architecture and mass balance purposes in order to compare its results with available data of lettuce grown in closed and controlled chambers. The carbon exchange rate, water absorption and evaporation rate, biomass fresh weight as well as leaf surface are modelled and compared with available data. The model consists of four modules. The first one evaluates plant architecture, like total leaf surface, leaf area index and stem length data. The second one calculates the rate of matter and energy exchange depending on architectural and environmental data: light absorption in the canopy, CO2 uptake or release, water uptake and evapotranspiration. The third module evaluates which of the previous rates is limiting overall biomass growth; and the last one calculates biomass growth rate depending on matter exchange rates, using a global stoichiometric equation. All these rates are a set of differential equations, which are integrated with time in order to provide

  4. PV Performance Modeling Methods and Practices: Results from the 4th PV Performance Modeling Collaborative Workshop.

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Joshua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-03-01

    In 2014, the IEA PVPS Task 13 added the PVPMC as a formal activity to its technical work plan for 2014-2017. The goal of this activity is to expand the reach of the PVPMC to a broader international audience and help to reduce PV performance modeling uncertainties worldwide. One of the main deliverables of this activity is to host one or more PVPMC workshops outside the US to foster more international participation within this collaborative group. This report reviews the results of the first in a series of these joint IEA PVPS Task 13/PVPMC workshops. The 4th PV Performance Modeling Collaborative Workshop was held in Cologne, Germany at the headquarters of TÜV Rheinland on October 22-23, 2015.

  5. Green Revolution for Exhibition Industry

    Institute of Scientific and Technical Information of China (English)

    Yan Manman

    2010-01-01

    @@ Shanghai World Expo is widely regarded as another grand international pageant, so many people thought that the opening ceremony must be as much magnificent and brilliant as the opening ceremony for Beijing Olympics.However, it was revealed by Wan Jifei, Executive Director of the ExecutiveCommittee of the Shanghai World Expo that the opening ceremony of the Expo was not that luxurious and extravagant as that for the Beijing Olympics, but would have its own characteristics under the elaborate design and thorough arrangement conducted by the host. The veto against that luxurious opening ceremony was actually a practice echoing for the concept of Green World Expo, which would be applied for every corner from the beginning to the end of the Expo, including the construction of exhibition hall, building of exhibition stand and advertisement etc.

  6. Communicating Complex Sciences by Means of Exhibitions

    Science.gov (United States)

    Schneider, S.

    2011-12-01

    Earth Sciences will have to take over the leading role in global sustainable policy and in discussions about climate change. Efforts to raise attention within the politically responsible communities as well as in the public are getting more and more support by executive and advisory boards all over the world. But how can you successfully communicate complex sciences? For example, to start communication about climate change, the first step is to encourage people to be concerned about climate change. After that, one has to start thinking about how to present data and how to include the presented data into an unprejudiced context. Therefore, the communication toolbox offers various methods to reach diverse audiences. The R&D programme GEOTECHNOLOGIEN conducts roving exhibitions as one of its most successful communication tools. With roving exhibitions GEOTECHNOLOGIEN is able to get in touch with different audiences at once. The main purpose and theme of these exhibitions is to convey the everyday means of climate change to the visitors. It is within the responsibility of science to communicate the effects of a phenomenon like climate change as well as the impact of research results to the everyday life of people. Currently, a GEOTECHNOLOGIEN roving exhibition on remote sensing with satellites deals with various issues of environmental research, including a chapter on climate change. By following the 3M-concept (Meaning - Memorable - Moving), exhibitions allow to connect the visitors daily environment and personal experiences with the presented issues and objects. Therefore, hands-on exhibits, exciting multimedia effects and high-tech artefacts have to be combined with interpretive text elements to highlight the daily significance of the scientific topics and the exhibition theme respectively. To create such an exhibition, strong conceptual planning has to be conducted. This includes the specification of stern financial as well as time wise milestones. In addition

  7. World Expo and Exhibition Industry

    Institute of Scientific and Technical Information of China (English)

    Guo Liqin

    2010-01-01

    @@ February 8 witnessed the construction of 2010 World Expo's China Pavilion completed after two years' work. The pavilion, in the shape of an oriental crown,showcases the spirit of traditional Chinese culture. It is significant since all other nation's pavilion constructed only for temporary exhibition, but China's Pavilion will be lasting architecture as the symbol of world civilization. Another similar famous case is Eiffel Tower which was built as the entrance of the world expo held in. 1889.

  8. A New Exhibition in Microcosm

    CERN Multimedia

    2000-01-01

    Sebastien Pelletier explains states of matter to an enthusiastic group of youngsters during the opening of a new exhibition in Microcosm last week. The Fun with Physics workshop will be offered to all 13-14 year olds in school groups visiting CERN this year. The new Microcosm contents have been developed in collaboration with the local teaching community, and cover particles and the forces that act between them.

  9. "Big Science" exhibition at Balexert

    CERN Multimedia

    2008-01-01

    CERN is going out to meet those members of the general public who were unable to attend the recent Open Day. The Laboratory will be taking its "Big Science" exhibition from the Globe of Science and Innovation to the Balexert shopping centre from 19 to 31 May 2008. The exhibition, which shows the LHC and its experiments through the eyes of a photographer, features around thirty spectacular photographs measuring 4.5 metres high and 2.5 metres wide. Welcomed and guided around the exhibition by CERN volunteers, shoppers at Balexert will also have the opportunity to discover LHC components on display and watch films. "Fun with Physics" workshops will be held at certain times of the day. Main hall of the Balexert shopping centre, ground floor, from 9.00 a.m. to 7.00 p.m. Monday to Friday and from 10 a.m. to 6 p.m. on the two Saturdays. Call for volunteers All members of the CERN personnel are invited to enrol as volunteers to help welcom...

  10. Contribution to modeling of the reflooding of a severely damaged reactor core using PRELUDE experimental results

    Energy Technology Data Exchange (ETDEWEB)

    Bachrata, A.; Fichot, F.; Repetto, G. [Institut de Radioprotection et de Surete Nucleaire IRSN, Cadarache (France); Quintard, M. [Universite de Toulouse, INPT, UPS, IMFT Institut de Mecanique des Fluides de Toulouse, Allee Camille Soula, F-31400 Toulouse (France); CNRS, IMFT, F-31400 Toulouse (France); Fleurot, J. [Institut de Radioprotection et de Surete Nucleaire IRSN, Cadarache (France)

    2012-07-01

    In case of accident at a nuclear power plant, water sources may not be available for a long period of time and the core heats up due to the residual power. The reflooding (injection of water into core) may be applied if the availability of safety injection is recovered during accident. If the injection becomes available only in the late phase of accident, water will enter a core configuration that will differ significantly from original rod-bundle geometry. Any attempt to inject water after significant core degradation can lead to further fragmentation of core material. The fragmentation of fuel rods may result in the formation of a 'debris bed'. The typical particle size in a debris bed might reach few millimeters (characteristic length-scale: 1 to 5 mm), i.e., a high permeability porous medium. The French 'Institut de Radioprotection et de Surete Nucleaire' is developing experimental programs (PEARL and PRELUDE) and simulation tools (ICARE-CATHARE and ASTEC) to study and optimize the severe accident management strategy and to assess the probabilities to stop the progress of in-vessel core degradation. It is shown that the quench front exhibits either a ID behaviour or a 2D one, depending on injection rate or bed characteristics. The PRELUDE experiment covers a rather large range of variation of parameters, for which the developed model appears to be quite predictive. (authors)

  11. Gas cooling in semi-analytic models and smoothed particle hydrodynamics simulations: are results consistent?

    Science.gov (United States)

    Saro, A.; De Lucia, G.; Borgani, S.; Dolag, K.

    2010-08-01

    We present a detailed comparison between the galaxy populations within a massive cluster, as predicted by hydrodynamical smoothed particle hydrodynamics (SPH) simulations and by a semi-analytic model (SAM) of galaxy formation. Both models include gas cooling and a simple prescription of star formation, which consists in transforming instantaneously any cold gas available into stars, while neglecting any source of energy feedback. This simplified comparison is thus not meant to be compared with observational data, but is aimed at understanding the level of agreement, at the stripped-down level considered, between two techniques that are widely used to model galaxy formation in a cosmological framework and which present complementary advantages and disadvantages. We find that, in general, galaxy populations from SAMs and SPH have similar statistical properties, in agreement with previous studies. However, when comparing galaxies on an object-by-object basis, we find a number of interesting differences: (i) the star formation histories of the brightest cluster galaxies (BCGs) from SAM and SPH models differ significantly, with the SPH BCG exhibiting a lower level of star formation activity at low redshift, and a more intense and shorter initial burst of star formation with respect to its SAM counterpart; (ii) while all stars associated with the BCG were formed in its progenitors in the SAM used here, this holds true only for half of the final BCG stellar mass in the SPH simulation, the remaining half being contributed by tidal stripping of stars from the diffuse stellar component associated with galaxies accreted on the cluster halo; (iii) SPH satellites can lose up to 90 per cent of their stellar mass at the time of accretion, due to tidal stripping, a process not included in the SAM used in this paper; (iv) in the SPH simulation, significant cooling occurs on the most massive satellite galaxies and this lasts for up to 1 Gyr after accretion. This physical process is

  12. Borneo 2007. Three European Exhibitions

    Directory of Open Access Journals (Sweden)

    Bernard Sellato

    2013-01-01

    Full Text Available The year 2007 appears to have been an exceptionally good one for Borneo in Europe. Two exhibitions were held in France, and one in Switzerland, which prominently featured the big island, its forests, its peoples, its cultures, and its arts. Here a brief review of these three events. Bornéo... Dayak et Punan. Peuples de la forêt tropicale humide, Musée d’Art et d’Archéologie, Laon, France, 25 November 2006 – 11 March 2007 The beautiful city of Laon, only a short distance by train or by car fro...

  13. CERN Permanent exhibitions short version

    CERN Multimedia

    2016-01-01

    Visits Explore by yourself the issues CERN's physicists are trying to solve: given that the entire universe is made of particles, where do they come from? Why do they behave in the way they do? Discover the massive apparatus used by physicists at CERN, like the LHC, and see how each part works. CERN invites the public to discover the mysteries of the Universe and the work of the world's biggest physics laboratory through free of charge guided tours and permanent exhibitions. As a group, with friends, individually, on foot, on your bike, come and discover CERN or explore it virtually. Welcome!

  14. Exhibits in libraries a practical guide

    CERN Document Server

    Brown, Mary E

    2005-01-01

    "Ccomprehensive...detailed"--Booklist; "thoroughly reseached...highly recommended"--Journal of Access Services. Library exhibits are more than entertainment for patrons. They can inspire and educate, stimulate an interest that can be explored in a book, or attract visitors who otherwise wouldn't stop by. Displays are also an opportunity for a library to put its creative foot forward or help patrons navigate the facility itself. This comprehensive "how-to" includes everything a librarian or staff member needs to know to put on an exhibit, from hatching ideas to evaluating the end result. Illustrations and photographs show practical methods of planning, labeling and displaying.

  15. Testing of Subgrid—Scale Stress Models by Using Results from Direct Numerical SImulations

    Institute of Scientific and Technical Information of China (English)

    HongruiGONG

    1998-01-01

    The most commonly used dynamic subgrid models,Germano's model and dynamic kinetic energy model,and their base models-the Smagorinsky model and the kinetic energy model,were tested using results from direct numerical simulations of various turbulent flows.In germano's dynamic model,the model coefficient was treated as a constant within the test filter,This treatment is conceptually inconsistent.An iteration procedure was proposed to calculate the model coefficient and an improved correlation coefficient was found.

  16. Multi-step cure kinetic model of ultra-thin glass fiber epoxy prepreg exhibiting both autocatalytic and diffusion-controlled regimes under isothermal and dynamic-heating conditions

    Science.gov (United States)

    Kim, Ye Chan; Min, Hyunsung; Hong, Sungyong; Wang, Mei; Sun, Hanna; Park, In-Kyung; Choi, Hyouk Ryeol; Koo, Ja Choon; Moon, Hyungpil; Kim, Kwang J.; Suhr, Jonghwan; Nam, Jae-Do

    2017-08-01

    As packaging technologies are demanded that reduce the assembly area of substrate, thin composite laminate substrates require the utmost high performance in such material properties as the coefficient of thermal expansion (CTE), and stiffness. Accordingly, thermosetting resin systems, which consist of multiple fillers, monomers and/or catalysts in thermoset-based glass fiber prepregs, are extremely complicated and closely associated with rheological properties, which depend on the temperature cycles for cure. For the process control of these complex systems, it is usually required to obtain a reliable kinetic model that could be used for the complex thermal cycles, which usually includes both the isothermal and dynamic-heating segments. In this study, an ultra-thin prepreg with highly loaded silica beads and glass fibers in the epoxy/amine resin system was investigated as a model system by isothermal/dynamic heating experiments. The maximum degree of cure was obtained as a function of temperature. The curing kinetics of the model prepreg system exhibited a multi-step reaction and a limited conversion as a function of isothermal curing temperatures, which are often observed in epoxy cure system because of the rate-determining diffusion of polymer chain growth. The modified kinetic equation accurately described the isothermal behavior and the beginning of the dynamic-heating behavior by integrating the obtained maximum degree of cure into the kinetic model development.

  17. Enrico Fermi exhibition at CERN

    CERN Document Server

    2002-01-01

    A touring exhibition celebrating the centenary of Enrico Fermi's birth in 1901 will be on display at CERN (Main Building, Mezzanine) from 12-27 September. You are cordially invited to the opening celebration on Thursday 12 September at 16:00 (Main Building, Council Chamber), which will include speechs from: Luciano Maiani Welcome and Introduction Arnaldo Stefanini Celebrating Fermi's Centenary in Documents and Pictures Antonino Zichichi The New 'Centro Enrico Fermi' at Via Panisperna Ugo Amaldi Fermi at Via Panisperna and the birth of Nuclear Medicine Jack Steinberger Fermi in Chicago Valentin Telegdi A Close-up of Fermi and the screening of a documentary video about Fermi: Scienziati a Pisa: Enrico Fermi (Scientists at Pisa: Enrico Fermi) created by Francesco Andreotti for La Limonaia from early film, photographs and sound recordings (In Italian, with English subtitles - c. 30 mins). This will be followed by an aperitif on the Mezz...

  18. Constraining performance assessment models with tracer test results: a comparison between two conceptual models

    Science.gov (United States)

    McKenna, Sean A.; Selroos, Jan-Olof

    Tracer tests are conducted to ascertain solute transport parameters of a single rock feature over a 5-m transport pathway. Two different conceptualizations of double-porosity solute transport provide estimates of the tracer breakthrough curves. One of the conceptualizations (single-rate) employs a single effective diffusion coefficient in a matrix with infinite penetration depth. However, the tracer retention between different flow paths can vary as the ratio of flow-wetted surface to flow rate differs between the path lines. The other conceptualization (multirate) employs a continuous distribution of multiple diffusion rate coefficients in a matrix with variable, yet finite, capacity. Application of these two models with the parameters estimated on the tracer test breakthrough curves produces transport results that differ by orders of magnitude in peak concentration and time to peak concentration at the performance assessment (PA) time and length scales (100,000 years and 1,000 m). These differences are examined by calculating the time limits for the diffusive capacity to act as an infinite medium. These limits are compared across both conceptual models and also against characteristic times for diffusion at both the tracer test and PA scales. Additionally, the differences between the models are examined by re-estimating parameters for the multirate model from the traditional double-porosity model results at the PA scale. Results indicate that for each model the amount of the diffusive capacity that acts as an infinite medium over the specified time scale explains the differences between the model results and that tracer tests alone cannot provide reliable estimates of transport parameters for the PA scale. Results of Monte Carlo runs of the transport models with varying travel times and path lengths show consistent results between models and suggest that the variation in flow-wetted surface to flow rate along path lines is insignificant relative to variability in

  19. Crows spontaneously exhibit analogical reasoning.

    Science.gov (United States)

    Smirnova, Anna; Zorina, Zoya; Obozova, Tanya; Wasserman, Edward

    2015-01-19

    Analogical reasoning is vital to advanced cognition and behavioral adaptation. Many theorists deem analogical thinking to be uniquely human and to be foundational to categorization, creative problem solving, and scientific discovery. Comparative psychologists have long been interested in the species generality of analogical reasoning, but they initially found it difficult to obtain empirical support for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]). Researchers have since mustered considerable evidence and argument that relational matching-to-sample (RMTS) effectively captures the essence of analogy, in which the relevant logical arguments are presented visually. In RMTS, choice of test pair BB would be correct if the sample pair were AA, whereas choice of test pair EF would be correct if the sample pair were CD. Critically, no items in the correct test pair physically match items in the sample pair, thus demanding that only relational sameness or differentness is available to support accurate choice responding. Initial evidence suggested that only humans and apes can successfully learn RMTS with pairs of sample and test items; however, monkeys have subsequently done so. Here, we report that crows too exhibit relational matching behavior. Even more importantly, crows spontaneously display relational responding without ever having been trained on RMTS; they had only been trained on identity matching-to-sample (IMTS). Such robust and uninstructed relational matching behavior represents the most convincing evidence yet of analogical reasoning in a nonprimate species, as apes alone have spontaneously exhibited RMTS behavior after only IMTS training. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Model validation: Issues regarding comparisons of point measurements and high-resolution modeling results

    Science.gov (United States)

    Sandvik, Anne D.; Skagseth, Øystein; Skogen, Morten D.

    2016-10-01

    In this study we compare a high resolution model of waters on the Norwegian Shelf with hydrographic observations obtained during 2009 at Ingøy, a fixed coastal station off northwestern Norway operated by the Institute of Marine Research. The observations comprise snapshots from Ingøy every two weeks, whereas the model represents an average over a certain volume and is continuous in time. We suggest that bias is the best way to compare the modeled and observed times series, while acknowledging the short-term variability (within a day) it is recommended to use the modeled range to estimate an acceptable deviation between single points in the series. Using the suggested method we conclude that an acceptable deviation between the modeled and observed surface temperatures at Ingøy is 0.6 °C. With such an acceptance level the model is correct in 27 out of 33 points for the time series considered.

  1. Comparison of Statistical Multifragmentation Model simulations with Canonical Thermodynamical Model results: a few representative cases

    CERN Document Server

    Botvina, A; Gupta, S Das; Mishustin, I

    2008-01-01

    The statistical multifragmentation model (SMM) has been widely used to explain experimental data of intermediate energy heavy ion collisions. A later entrant in the field is the canonical thermodynamic model (CTM) which is also being used to fit experimental data. The basic physics of both the models is the same, namely that fragments are produced according to their statistical weights in the available phase space. However, they are based on different statistical ensembles, and the methods of calculation are different: while the SMM uses Monte-Carlo simulations, the CTM solves recursion relations. In this paper we compare the predictions of the two models for a few representative cases.

  2. Synchronization in multicell systems exhibiting dynamic plasticity

    Indian Academy of Sciences (India)

    C Suguna; Somdatta Sinha

    2008-08-01

    Collective behaviour in multicell systems arises from exchange of chemicals/signals between cells and may be different from their intrinsic behaviour. These chemicals are products of regulated networks of biochemical pathways that underlie cellular functions, and can exhibit a variety of dynamics arising from the non-linearity of the reaction processes. We have addressed the emergent synchronization properties of a ring of cells, diffusively coupled by the end product of an intracellular model biochemical pathway exhibiting non-robust birhythmic behaviour. The aim is to examine the role of intercellular interaction in stabilizing the non-robust dynamics in the emergent collective behaviour in the ring of cells. We show that, irrespective of the inherent frequencies of individual cells, depending on the coupling strength, the collective behaviour does synchronize to only one type of oscillations above a threshold number of cells. Using two perturbation analyses, we also show that this emergent synchronized dynamical state is fairly robust under external perturbations. Thus, the inherent plasticity in the oscillatory phenotypes in these model cells may get suppressed to exhibit collective dynamics of a single type in a multicell system, but environmental influences can sometimes expose this underlying plasticity in its collective dynamics.

  3. Regression mixture models : Does modeling the covariance between independent variables and latent classes improve the results?

    NARCIS (Netherlands)

    Lamont, A.E.; Vermunt, J.K.; Van Horn, M.L.

    2016-01-01

    Regression mixture models are increasingly used as an exploratory approach to identify heterogeneity in the effects of a predictor on an outcome. In this simulation study, we tested the effects of violating an implicit assumption often made in these models; that is, independent variables in the

  4. Modeling drifting snow in Antarctica with a regional climate model: 2. Results

    NARCIS (Netherlands)

    Lenaerts, J.T.M.; van den Broeke, M.R.

    2012-01-01

    This paper presents a model study of the impact of drifting snow on the lower atmosphere, surface snow characteristics, and surface mass balance of Antarctica. We use the regional atmospheric climate model RACMO2.1/ANT with a high horizontal resolution (27 km), equipped with a drifting snow routine

  5. Modeling drifting snow in Antarctica with a regional climate model: 2. Results

    NARCIS (Netherlands)

    Lenaerts, J.T.M.|info:eu-repo/dai/nl/314850163; van den Broeke, M.R.|info:eu-repo/dai/nl/073765643

    2012-01-01

    This paper presents a model study of the impact of drifting snow on the lower atmosphere, surface snow characteristics, and surface mass balance of Antarctica. We use the regional atmospheric climate model RACMO2.1/ANT with a high horizontal resolution (27 km), equipped with a drifting snow routine

  6. In Silico Model for Developmental Toxicity: How to Use QSAR Models and Interpret Their Results.

    Science.gov (United States)

    Marzo, Marco; Roncaglioni, Alessandra; Kulkarni, Sunil; Barton-Maclaren, Tara S; Benfenati, Emilio

    2016-01-01

    Modeling developmental toxicity has been a challenge for (Q)SAR model developers due to the complexity of the endpoint. Recently, some new in silico methods have been developed introducing the possibility to evaluate the integration of existing methods by taking advantage of various modeling perspectives. It is important that the model user is aware of the underlying basis of the different models in general, as well as the considerations and assumptions relative to the specific predictions that are obtained from these different models for the same chemical. The evaluation on the predictions needs to be done on a case-by-case basis, checking the analogs (possibly using structural, physicochemical, and toxicological information); for this purpose, the assessment of the applicability domain of the models provides further confidence in the model prediction. In this chapter, we present some examples illustrating an approach to combine human-based rules and statistical methods to support the prediction of developmental toxicity; we also discuss assumptions and uncertainties of the methodology.

  7. Gas cooling in semi-analytic models and SPH simulations: are results consistent?

    CERN Document Server

    Saro, A; Borgani, S; Dolag, K

    2010-01-01

    We present a detailed comparison between the galaxy populations within a massive cluster, as predicted by hydrodynamical SPH simulations and by a semi-analytic model (SAM) of galaxy formation. Both models include gas cooling and a simple prescription of star formation, which consists in transforming instantaneously any cold gas available into stars, while neglecting any source of energy feedback. We find that, in general, galaxy populations from SAMs and SPH have similar statistical properties, in agreement with previous studies. However, when comparing galaxies on an object-by-object basis, we find a number of interesting differences: a) the star formation histories of the brightest cluster galaxies (BCGs) from SAM and SPH models differ significantly, with the SPH BCG exhibiting a lower level of star formation activity at low redshift, and a more intense and shorter initial burst of star formation with respect to its SAM counterpart; b) while all stars associated with the BCG were formed in its progenitors i...

  8. Cystamine preparations exhibit anticoagulant activity.

    Science.gov (United States)

    Aleman, Maria M; Holle, Lori A; Stember, Katherine G; Devette, Christa I; Monroe, Dougald M; Wolberg, Alisa S

    2015-01-01

    Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl)-lysyl crosslinks between proteins. Cystamine blocks transglutaminase activity and is used in vitro in human samples and in vivo in mice and rats in studies of coagulation, immune dysfunction, and inflammatory disease. These studies have suggested cystamine blocks fibrin crosslinking and has anti-inflammatory effects, implicating transglutaminase activity in the pathogenesis of several diseases. We measured the effects of cystamine on fibrin crosslinking, tissue factor-triggered plasma clot formation and thrombin generation, and coagulation factor enzymatic activity. At concentrations that blocked fibrin crosslinking, cystamine also inhibited plasma clot formation and reduced thrombin generation. Cystamine inhibited the amidolytic activity of coagulation factor XI and thrombin towards chromogenic substrates. These findings demonstrate that cystamine exhibits anticoagulant activity during coagulation. Given the close relationship between coagulation and inflammation, these findings suggest prior studies that used cystamine to implicate transglutaminase activity in disease pathogenesis warrant re-examination.

  9. Cystamine preparations exhibit anticoagulant activity.

    Directory of Open Access Journals (Sweden)

    Maria M Aleman

    Full Text Available Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl-lysyl crosslinks between proteins. Cystamine blocks transglutaminase activity and is used in vitro in human samples and in vivo in mice and rats in studies of coagulation, immune dysfunction, and inflammatory disease. These studies have suggested cystamine blocks fibrin crosslinking and has anti-inflammatory effects, implicating transglutaminase activity in the pathogenesis of several diseases. We measured the effects of cystamine on fibrin crosslinking, tissue factor-triggered plasma clot formation and thrombin generation, and coagulation factor enzymatic activity. At concentrations that blocked fibrin crosslinking, cystamine also inhibited plasma clot formation and reduced thrombin generation. Cystamine inhibited the amidolytic activity of coagulation factor XI and thrombin towards chromogenic substrates. These findings demonstrate that cystamine exhibits anticoagulant activity during coagulation. Given the close relationship between coagulation and inflammation, these findings suggest prior studies that used cystamine to implicate transglutaminase activity in disease pathogenesis warrant re-examination.

  10. EU Climate Change Exhibition Held

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>On April 25, the CPAFFC, the China-EU Association (CEUA) and the Delegation of the European Commission to China jointly held the opening ceremony for the EU Exhibition on Climate Change in the CPAFFC. He Luli, former vice chairperson of the NPC Standing Committee and honorary president of the CEUA, Jose Manuel Barroso, president of the European Commission, and Li Jianping, vice president of the CPAFFC, attended the opening ceremony and made speeches. Honorary President He Luli highly praised the achievements made by China and the EU in their longtime cooperation of mutual benefits in various fields including environmental protection. She said, for many years China and EU have both committed to the development of all-round strategic partnership and establishment of a multi-level mechanism of political dialogue. She expressed, with increasing enthusiasm the CEUA would continue to actively carry out nongovernmental exchanges between China and the EU, and promote cooperation between the two sides in the fields of economy, society, environmental protection, science and technology, culture, etc.

  11. Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome.

    Science.gov (United States)

    Feng, Xiaomei; Degos, Vincent; Koch, Lauren G; Britton, Steven L; Zhu, Yinggang; Vacas, Susana; Terrando, Niccolò; Nelson, Jeffrey; Su, Xiao; Maze, Mervyn

    2013-05-01

    Postoperative cognitive decline can be reproduced in animal models. In a well-validated rat model of the Metabolic Syndrome, we sought to investigate whether surgery induced a more severe and persistent form of cognitive decline similar to that noted in preliminary clinical studies. In rats that had been selectively bred for low and high exercise endurance, the low capacity runners (LCR) exhibited features of Metabolic Syndrome (obesity, dyslipidemia, insulin resistance, and hypertension). Tibial fracture surgery was performed under isoflurane anesthesia in LCR and high capacity runner (HCR) rats and cognitive function was assessed postoperatively in a trace-fear conditioning paradigm and Morris Water Maze; non-operated rats were exposed to anesthesia and analgesia (sham). Group sizes were n = 6. On postoperative D7, LCR rats had shorter freezing times than postoperative HCR rats. Five months postoperatively, LCR rats had a flatter learning trajectory and took longer to locate the submerged platform than postoperative HCR rats; dwell-time in the target quadrant in a probe trial was shorter in the postoperative LCR compared to HCR rats. LCR and HCR sham rats did not differ in any test. Postoperatively, LCR rats diverged from HCR rats exhibiting a greater decline in memory, acutely, with persistent learning and memory decline, remotely; this could not be attributed to changes in locomotor or swimming performance. This Metabolic Syndrome animal model of surgery-induced cognitive decline corroborates, with high fidelity, preliminary findings of postoperative cognitive dysfunction in Metabolic Syndrome patients.

  12. Recent results of searches for beyond Standard Model physics in ATLAS

    CERN Document Server

    Serkin, Leonid; The ATLAS collaboration

    2017-01-01

    Recent results of searches for beyond Standard Model physics in ATLAS are presented, with particular focus on searches for new phenomena in high jet multiplicity final states. No significant excess are observed and limits are set on several signal models.

  13. The MARINA model (Model to Assess River Inputs of Nutrients to seAs): Model description and results for China.

    Science.gov (United States)

    Strokal, Maryna; Kroeze, Carolien; Wang, Mengru; Bai, Zhaohai; Ma, Lin

    2016-08-15

    Chinese agriculture has been developing fast towards industrial food production systems that discharge nutrient-rich wastewater into rivers. As a result, nutrient export by rivers has been increasing, resulting in coastal water pollution. We developed a Model to Assess River Inputs of Nutrients to seAs (MARINA) for China. The MARINA Nutrient Model quantifies river export of nutrients by source at the sub-basin scale as a function of human activities on land. MARINA is a downscaled version for China of the Global NEWS-2 (Nutrient Export from WaterSheds) model with an improved approach for nutrient losses from animal production and population. We use the model to quantify dissolved inorganic and organic nitrogen (N) and phosphorus (P) export by six large rivers draining into the Bohai Gulf (Yellow, Hai, Liao), Yellow Sea (Yangtze, Huai) and South China Sea (Pearl) in 1970, 2000 and 2050. We addressed uncertainties in the MARINA Nutrient model. Between 1970 and 2000 river export of dissolved N and P increased by a factor of 2-8 depending on sea and nutrient form. Thus, the risk for coastal eutrophication increased. Direct losses of manure to rivers contribute to 60-78% of nutrient inputs to the Bohai Gulf and 20-74% of nutrient inputs to the other seas in 2000. Sewage is an important source of dissolved inorganic P, and synthetic fertilizers of dissolved inorganic N. Over half of the nutrients exported by the Yangtze and Pearl rivers originated from human activities in downstream and middlestream sub-basins. The Yellow River exported up to 70% of dissolved inorganic N and P from downstream sub-basins and of dissolved organic N and P from middlestream sub-basins. Rivers draining into the Bohai Gulf are drier, and thus transport fewer nutrients. For the future we calculate further increases in river export of nutrients. The MARINA Nutrient model quantifies the main sources of coastal water pollution for sub-basins. This information can contribute to formulation of

  14. The Evaluation Model About the Result of Enterprise Technological Innovation Based on DAGF Algorithm

    Institute of Scientific and Technical Information of China (English)

    LikeMao; ZigangZhang

    2004-01-01

    Based on DAGF Algorithm, an evaluation model about the result of enterprise's technological innovation is proposed. Furthermore, establishment of its system of evaluation indicators and DAGF Algorithm are discussed in detail. Besides, the result of the case shows that the model is fit for evaluation of the result of enterprise's technological innovation.

  15. Evaluation model for the implementation results of mine law based on neural network

    Science.gov (United States)

    Gu, Tao; Li, Xu

    2010-04-01

    To evaluate the implementation results of mine safety production law, the evaluation model based on neural network is presented. In this model, 63 indicators which can describe the mine law effectively are proposed. The evaluation system is developed by using the model and the 63 indicators. The evaluation results show that the proposed method has high accuracy. We can effectively estimate the score of one mine for its carrying out the safety law. The estimate results are of scientific credibility and impartiality.

  16. Modeling chemistry in and above snow at Summit, Greenland – Part 1: Model description and results

    Directory of Open Access Journals (Sweden)

    J. L. Thomas

    2010-12-01

    Full Text Available Sun-lit snow is increasingly recognized as a chemical reactor that plays an active role in uptake, transformation, and release of atmospheric trace gases. Snow is known to influence boundary layer air on a local scale, and given the large global surface coverage of snow may also be significant on regional and global scales.

    We present a new detailed one-dimensional snow chemistry module that has been coupled to the 1-D atmospheric boundary layer model MISTRA, we refer to the coupled model as MISTRA-SNOW. The new 1-D snow module, which is dynamically coupled to the overlaying atmospheric model, includes heat transport in the snowpack, molecular diffusion, and wind pumping of gases in the interstitial air. The model includes gas phase photochemistry and chemical reactions both in the interstitial air and the atmosphere. Heterogeneous and multiphase chemistry on atmospheric aerosol is considered explicitly. The chemical interaction of interstitial air with snow grains is simulated assuming chemistry in a liquid (aqueous layer on the grain surface. The model was used to investigate snow as the source of nitrogen oxides (NOx and gas phase reactive bromine in the atmospheric boundary layer in the remote snow covered Arctic (over the Greenland ice sheet as well as to investigate the link between halogen cycling and ozone depletion that has been observed in interstitial air. The model is validated using data taken 10 June–13 June, 2008 as part of the Greenland Summit Halogen-HOx experiment (GSHOX. The model predicts that reactions involving bromide and nitrate impurities in the surface snow at Summit can sustain atmospheric NO and BrO mixing ratios measured at Summit during this period.

  17. Annual Report On China's Exhibition Industry 2009(II)

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Section II Features of China's Exhibition Market To better reflect the features of China's exhibition market,based on the research results from 2005 t0 2008,the research team in 2009 continued to make a thorough survey of the exhibition market in Beijing,Shanghai and Guangzhou.

  18. Global net land carbon sink: Results from the Multi-scale Synthesis and Terrestrial Model Intercomparison Project (MsTMIP)

    Science.gov (United States)

    Huntzinger, D. N.; Schwalm, C. R.; Michalak, A. M.; Cook, R. B.; Jacobson, A. R.; Schaefer, K. M.; Dasgupta, A.; Poco, J.

    2013-12-01

    The Multi-scale Synthesis and Model Intercomparison Project (MsTMIP) is a formal model intercomparison effort focused on improving the diagnosis and attribution of carbon exchange at regional and global scales. Here we present results from the terrestrial biospheric models participating in the MsTMIP effort, focusing on global and regional model estimates of the net land carbon sink. When compared to estimates of the residual net land sink inferred from atmospheric CO2 observations (i.e., fossil fuel emission + land use land cover change - atmospheric increase - ocean uptake), MsTMIP models predict, on average, a weaker global net land uptake of carbon. There is a large spread in MsTMIP estimates of the net land sink (e.g., -2.5 to 5.0 Pg C/yr in 2010, where a negative flux represents a net release to the atmosphere). Some models consistently show the land surface as a net source of carbon to the atmosphere, which is inconsistent with the atmospheric record. In addition, we examine how model estimates of the cumulative global net sink diverge over the period 1900 to 2010, and the degree to which model sensitivity to forcing factors and fundamental differences in model formulation contribute to this divergence. We link differences in estimates of the cumulative land sink back to each model's sensitivity to key forcing factors including climate variability, CO2 fertilization, nitrogen limitation, and land cover / land-use change. For example, the strength of carbon uptake in most models appears to be strongly coupled with atmospheric CO2 concentrations (CO2 fertilization effect). The strength of this relationship, however, varies across models with some models exhibiting a very strong CO2 fertilization effect (e.g., ORCHIDEE), while others not so (e.g., CLM). To inform the comparison across models, structural differences (i.e., which processes are included and how those processes are parameterized) among the participating models are evaluated using hierarchical

  19. Exhibition of Design, Development and Manufacturing of Scalp Cooling Cap

    OpenAIRE

    2016-01-01

    Exhibition Narrative:\\ud University of Huddersfield and Paxman Coolers Limited showcased the output of a collaborative project that resulted in an innovative scalp-cooling cap at Arab Health 2016 Exhibition Dubai, UEA. In collaboration with Medilink Yorkshire & Humber at the Stand No: Z1G57. The Arab Health 2016 exhibition showcased more than 4,000 companies exhibiting their latest innovations to more than 130,000 healthcare professionals attending from 163 countries.

  20. Exact results for the behavior of the thermodynamic Casimir force in a model with a strong adsorption

    Science.gov (United States)

    Dantchev, Daniel M.; Vassilev, Vassil M.; Djondjorov, Peter A.

    2016-09-01

    When massless excitations are limited or modified by the presence of material bodies one observes a force acting between them generally called Casimir force. Such excitations are present in any fluid system close to its true bulk critical point. We derive exact analytical results for both the temperature and external ordering field behavior of the thermodynamic Casimir force within the mean-field Ginzburg-Landau Ising type model of a simple fluid or binary liquid mixture. We investigate the case when under a film geometry the boundaries of the system exhibit strong adsorption onto one of the phases (components) of the system. We present analytical and numerical results for the (temperature-field) relief map of the force in both the critical region of the film close to its finite-size or bulk critical points as well as in the capillary condensation regime below but close to the finite-size critical point.

  1. THE CORRELATION OF EXPERIMENTAL RESULTS OF THE COMPOSITE MATERIALS HARDNESS WITH THEORETICAL RESULTS OF A MATHEMATICAL MODEL

    Directory of Open Access Journals (Sweden)

    Minodora Maria PASARE

    2014-05-01

    Full Text Available In this paper is about of the Hays-Kendall theoretical model of testing the microhardness of the composites materials of NiP/SiC type. We used an indenter to establish the microhardness of the composite and different types of loads. The microhardness can be interpreted using a theoretical model Hays-Kendall and the Kick model.

  2. LHC INAUGURATION, LHC Fest highlights: exhibition time!

    CERN Multimedia

    2008-01-01

    David Gross, one of the twenty-one Nobel Laureates who have participated in the project.Tuesday 21 October 2008 Accelerating Nobels Colliding Charm, Atomic Cuisine, The Good Anomaly, A Quark Somewhere on the White Paper, Wire Proliferation, A Tale of Two Liquids … these are just some of the titles given to artworks by Physics Nobel Laureates who agreed to make drawings of their prize-winning discoveries (more or less reluctantly) during a special photo session. Science photographer Volker Steger made portraits of Physics Nobel Laureates and before the photo sessions he asked them to make a drawing of their most important discovery. The result is "Accelerating Nobels", an exhibition that combines unusual portraits of and original drawings by twenty-one Nobel laureates in physics whose work is closely related to CERN and the LHC. This exhibition will be one of the highlights of the LHC celebrations on 21 October in the SM18 hall b...

  3. Photovoltaic Grid-Connected Modeling and Characterization Based on Experimental Results

    Science.gov (United States)

    Humada, Ali M.; Hojabri, Mojgan; Sulaiman, Mohd Herwan Bin; Hamada, Hussein M.; Ahmed, Mushtaq N.

    2016-01-01

    A grid-connected photovoltaic (PV) system operates under fluctuated weather condition has been modeled and characterized based on specific test bed. A mathematical model of a small-scale PV system has been developed mainly for residential usage, and the potential results have been simulated. The proposed PV model based on three PV parameters, which are the photocurrent, IL, the reverse diode saturation current, Io, the ideality factor of diode, n. Accuracy of the proposed model and its parameters evaluated based on different benchmarks. The results showed that the proposed model fitting the experimental results with high accuracy compare to the other models, as well as the I-V characteristic curve. The results of this study can be considered valuable in terms of the installation of a grid-connected PV system in fluctuated climatic conditions. PMID:27035575

  4. Extension of Some Classical Results on Ruin Probability to Delayed Renewal Model

    Institute of Scientific and Technical Information of China (English)

    Chun Su; Tao Jiang; Qi-he Tang

    2002-01-01

    Embrechts and Veraverbeke[2] investigated the renewal risk model and gave a tail equivalence relationship of the ruin probabilities ψ(x) under the assumption that the claim size is heavy-tailed, which is regarded as a classical result in the context of extremal value theory. In this note we extend this result to the delayed renewal risk model.

  5. Behavioral Change as a Result of Videotaped Playback: An Examination of Two Models.

    Science.gov (United States)

    Ronchi, Don; Ripple, Richard E.

    The literature on the behavior effects of videotaped playback reveals that little theoretical formulation has been offered to explain the positive results which have been reported. Two theoretical models are considered in regard to these results. The first, a reinforcement model, suggests that some behaviors are reinforced positively and some…

  6. Review on optical constants of Titan aerosols: Experimental results and modeling/observational data

    Science.gov (United States)

    Brassé, Coralie; Muñoz, Olga; Coll, Patrice; Raulin, François

    2014-05-01

    During the last years many studies have been performed to improve the experimental database of optical constants of Titan aerosols. Indeed, the determination of the optical constants of these particles is essential to quantify their capacity to absorb and to scatter solar radiation, and thus to evaluate their role on Titan's radiative balance and climate. The study of optical properties is also crucial to analyze and to better interpret many of Titan's observational data, in particular those acquired during the Cassini-Huygens mission. One way to determine Titan aerosols optical constant is to measure the optical constants of analogues of Titan complex organic material synthesized in the laboratory, usually named Titan's tholins (Sagan and Khare, 1979). But the optical constants depend on the chemical composition, the size and the shape of particles (Raulin et al., 2012). Those three parameters result from the experimental conditions such as energy source, gas mixing ratio, gas pressure, flow rate and irradiation time (Cable et al., 2012). Besides the determination of the refractive index in the laboratory, there are others methods using theoretical models or observational data. Nevertheless, theoretical models are based on laboratory data or/and observational data. The visible - near infrared spectral region of optical constants has been widely studied with laboratory analogues. Comparison of the obtained results suggest that tholins synthesized by Tran et al. (2003) and Majhoub et al. (2012) are the best representative of Titan aerosols with regards to their refractive indexes in this spectral region. The mid-infrared spectral range has been studied only by Imanaka et al. (2012) and slightly by Tran et al. (2003). In that spectral range, Titan tholins do not exhibit the features displayed by Kim and Courtin (2013) from Titan's observations. For spectral region of wavelengths smaller than 0.20µm or higher than 25µm, only the data from Khare et al. (1984) are

  7. Recent results on the spatiotemporal modelling and comparative analysis of Black Death and bubonic plague epidemics

    Science.gov (United States)

    Christakos, G.; Olea, R.A.; Yu, H.-L.

    2007-01-01

    Background: This work demonstrates the importance of spatiotemporal stochastic modelling in constructing maps of major epidemics from fragmentary information, assessing population impacts, searching for possible etiologies, and performing comparative analysis of epidemics. Methods: Based on the theory previously published by the authors and incorporating new knowledge bases, informative maps of the composite space-time distributions were generated for important characteristics of two major epidemics: Black Death (14th century Western Europe) and bubonic plague (19th-20th century Indian subcontinent). Results: The comparative spatiotemporal analysis of the epidemics led to a number of interesting findings: (1) the two epidemics exhibited certain differences in their spatiotemporal characteristics (correlation structures, trends, occurrence patterns and propagation speeds) that need to be explained by means of an interdisciplinary effort; (2) geographical epidemic indicators confirmed in a rigorous quantitative manner the partial findings of isolated reports and time series that Black Death mortality was two orders of magnitude higher than that of bubonic plague; (3) modern bubonic plague is a rural disease hitting harder the small villages in the countryside whereas Black Death was a devastating epidemic that indiscriminately attacked large urban centres and the countryside, and while the epidemic in India lasted uninterruptedly for five decades, in Western Europe it lasted three and a half years; (4) the epidemics had reverse areal extension features in response to annual seasonal variations. Temperature increase at the end of winter led to an expansion of infected geographical area for Black Death and a reduction for bubonic plague, reaching a climax at the end of spring when the infected area in Western Europe was always larger than in India. Conversely, without exception, the infected area during winter was larger for the Indian bubonic plague; (5) during the

  8. COMPUTATIONAL FLUID DYNAMICS MODELING OF SCALED HANFORD DOUBLE SHELL TANK MIXING - CFD MODELING SENSITIVITY STUDY RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    JACKSON VL

    2011-08-31

    The primary purpose of the tank mixing and sampling demonstration program is to mitigate the technical risks associated with the ability of the Hanford tank farm delivery and celtification systems to measure and deliver a uniformly mixed high-level waste (HLW) feed to the Waste Treatment and Immobilization Plant (WTP) Uniform feed to the WTP is a requirement of 24590-WTP-ICD-MG-01-019, ICD-19 - Interface Control Document for Waste Feed, although the exact definition of uniform is evolving in this context. Computational Fluid Dynamics (CFD) modeling has been used to assist in evaluating scaleup issues, study operational parameters, and predict mixing performance at full-scale.

  9. Seeking for the rational basis of the Median Model: the optimal combination of multi-model ensemble results

    Directory of Open Access Journals (Sweden)

    A. Riccio

    2007-12-01

    Full Text Available In this paper we present an approach for the statistical analysis of multi-model ensemble results. The models considered here are operational long-range transport and dispersion models, also used for the real-time simulation of pollutant dispersion or the accidental release of radioactive nuclides.

    We first introduce the theoretical basis (with its roots sinking into the Bayes theorem and then apply this approach to the analysis of model results obtained during the ETEX-1 exercise. We recover some interesting results, supporting the heuristic approach called "median model", originally introduced in Galmarini et al. (2004a, b.

    This approach also provides a way to systematically reduce (and quantify model uncertainties, thus supporting the decision-making process and/or regulatory-purpose activities in a very effective manner.

  10. Seeking for the rational basis of the median model: the optimal combination of multi-model ensemble results

    Directory of Open Access Journals (Sweden)

    A. Riccio

    2007-04-01

    Full Text Available In this paper we present an approach for the statistical analysis of multi-model ensemble results. The models considered here are operational long-range transport and dispersion models, also used for the real-time simulation of pollutant dispersion or the accidental release of radioactive nuclides.

    We first introduce the theoretical basis (with its roots sinking into the Bayes theorem and then apply this approach to the analysis of model results obtained during the ETEX-1 exercise. We recover some interesting results, supporting the heuristic approach called "median model", originally introduced in Galmarini et al. (2004a, b.

    This approach also provides a way to systematically reduce (and quantify model uncertainties, thus supporting the decision-making process and/or regulatory-purpose activities in a very effective manner.

  11. Preliminary Results of the first European Source Apportionment intercomparison for Receptor and Chemical Transport Models

    Science.gov (United States)

    Belis, Claudio A.; Pernigotti, Denise; Pirovano, Guido

    2017-04-01

    Source Apportionment (SA) is the identification of ambient air pollution sources and the quantification of their contribution to pollution levels. This task can be accomplished using different approaches: chemical transport models and receptor models. Receptor models are derived from measurements and therefore are considered as a reference for primary sources urban background levels. Chemical transport model have better estimation of the secondary pollutants (inorganic) and are capable to provide gridded results with high time resolution. Assessing the performance of SA model results is essential to guarantee reliable information on source contributions to be used for the reporting to the Commission and in the development of pollution abatement strategies. This is the first intercomparison ever designed to test both receptor oriented models (or receptor models) and chemical transport models (or source oriented models) using a comprehensive method based on model quality indicators and pre-established criteria. The target pollutant of this exercise, organised in the frame of FAIRMODE WG 3, is PM10. Both receptor models and chemical transport models present good performances when evaluated against their respective references. Both types of models demonstrate quite satisfactory capabilities to estimate the yearly source contributions while the estimation of the source contributions at the daily level (time series) is more critical. Chemical transport models showed a tendency to underestimate the contribution of some single sources when compared to receptor models. For receptor models the most critical source category is industry. This is probably due to the variety of single sources with different characteristics that belong to this category. Dust is the most problematic source for Chemical Transport Models, likely due to the poor information about this kind of source in the emission inventories, particularly concerning road dust re-suspension, and consequently the

  12. Numerical modelling of radon-222 entry into houses: An outline of techniques and results

    DEFF Research Database (Denmark)

    Andersen, C.E.

    2001-01-01

    Numerical modelling is a powerful tool for studies of soil gas and radon-222 entry into houses. It is the purpose of this paper to review some main techniques and results. In the past, modelling has focused on Darcy flow of soil gas (driven by indoor–outdoor pressure differences) and combined...... diffusive and advective transport of radon. Models of different complexity have been used. The simpler ones are finite-difference models with one or two spatial dimensions. The more complex models allow for full three-dimensional and time dependency. Advanced features include: soil heterogeneity, anisotropy......, fractures, moisture, non-uniform soil temperature, non-Darcy flow of gas, and flow caused by changes in the atmospheric pressure. Numerical models can be used to estimate the importance of specific factors for radon entry. Models are also helpful when results obtained in special laboratory or test structure...

  13. Parallel Path Magnet Motor: Development of the Theoretical Model and Analysis of Experimental Results

    Science.gov (United States)

    Dirba, I.; Kleperis, J.

    2011-01-01

    Analytical and numerical modelling is performed for the linear actuator of a parallel path magnet motor. In the model based on finite-element analysis, the 3D problem is reduced to a 2D problem, which is sufficiently precise in a design aspect and allows modelling the principle of a parallel path motor. The paper also describes a relevant numerical model and gives comparison with experimental results. The numerical model includes all geometrical and physical characteristics of the motor components. The magnetic flux density and magnetic force are simulated using FEMM 4.2 software. An experimental model has also been developed and verified for the core of switchable magnetic flux linear actuator and motor. The results of experiments are compared with those of theoretical/analytical and numerical modelling.

  14. Liu Hong: no trivial on exhibitions

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    To Work for Tomorrow Liu Hong, General Manager of TUTTI Exhibition Service (Xiamen) Co., Ltd, has set up TUTTI Exhibition Service (Xiamen) Co., Ltd in 2001, when exhibition industry firstly appear in Xiamen. Furthermore, the company has developed rapidly in recent years. As Liu Hong regards, exhibition industry, as well as advertisement industry, is an industry filled with challenges and followed

  15. Comparison of fully coupled hydroelastic computation and segmented model test results for slamming and whipping loads

    Directory of Open Access Journals (Sweden)

    Jung-Hyun Kim

    2014-12-01

    Full Text Available This paper presents a numerical analysis of slamming and whipping using a fully coupled hydroelastic model. The coupled model uses a 3-D Rankine panel method, a 1-D or 3-D finite element method, and a 2-D Generalized Wagner Model (GWM, which are strongly coupled in time domain. First, the GWM is validated against results of a free drop test of wedges. Second, the fully coupled method is validated against model test results for a 10,000 twenty-foot equivalent unit (TEU containership. Slamming pressures and whipping responses to regular waves are compared. A spatial distribution of local slamming forces is measured using 14 force sensors in the model test, and it is compared with the integration of the pressure distribution by the computation. Furthermore, the pressure is decomposed into the added mass, impact, and hydrostatic components, in the computational results. The validity and characteristics of the numerical model are discussed.

  16. Comparison between InfoWorks hydraulic results and a physical model of an urban drainage system.

    Science.gov (United States)

    Rubinato, Matteo; Shucksmith, James; Saul, Adrian J; Shepherd, Will

    2013-01-01

    Urban drainage systems are frequently analysed using hydraulic modelling software packages such as InfoWorks CS or MIKE-Urban. The use of such modelling tools allows the evaluation of sewer capacity and the likelihood and impact of pluvial flood events. Models can also be used to plan major investments such as increasing storage capacity or the implementation of sustainable urban drainage systems. In spite of their widespread use, when applied to flooding the results of hydraulic models are rarely compared with field or laboratory (i.e. physical modelling) data. This is largely due to the time and expense required to collect reliable empirical data sets. This paper describes a laboratory facility which will enable an urban flood model to be verified and generic approaches to be built. Results are presented from the first phase of testing, which compares the sub-surface hydraulic performance of a physical scale model of a sewer network in Yorkshire, UK, with downscaled results from a calibrated 1D InfoWorks hydraulic model of the site. A variety of real rainfall events measured in the catchment over a period of 15 months (April 2008-June 2009) have been both hydraulically modelled and reproduced in the physical model. In most cases a comparison of flow hydrographs generated in both hydraulic and physical models shows good agreement in terms of velocities which pass through the system.

  17. The Twitter-thing (exhibition)

    DEFF Research Database (Denmark)

    Birkbak, Andreas; Bornakke, Tobias; Papazu, Irina Maria Clara Hansen

    is created between that hashtag and the parliamentarian. The tool then generates a network visualization showing how parliamentarians group around topics and issues. The resulting ‘issue publics’ – or things in the sense of a collective aroused by an issue – are also ‘data publics’ because...... they are not necessarily aware of themselves as publics. At the same time, it is possible to self-select membership of these publics by using a specific hashtag. This raises the question of what feedback loops are at work between visualizations and those being visualized. How might a tool like the Twitter-thing change...

  18. Empirical Evaluation of the Proposed eXSCRUM Model-Results of a Case Study

    Directory of Open Access Journals (Sweden)

    M Rizwan Jameel Qureshi

    2011-05-01

    Full Text Available Agile models promote fast development. XP and Scrum are the most widely used agile models. This paper investigates the phases of XP and Scrum models in order to identify their potentials and drawbacks. XP model has certain drawbacks, such as not suitable for maintenance projects and poor performance for medium and large-scale development projects. Scrum model has certain limitations, such as lacked in engineering practices. Since, both XP and Scrum models contain good features and strengths but still there are improvement possibilities in these models. Majority of the software development companies are reluctant to switch from traditional methodologies to agile methodologies for development of industrial projects. A fine integration, of software management of the Scrum model and engineering practices of XP model, is very much required to accumulate the strengths and remove the limitations of both models. This is achieved by proposing an eXScrum model. The proposed model is validated by conducting a controlled case study. The results of case study show that the proposed integrated eXScrum model enriches the potentials of both XP and Scrum models and eliminates their drawbacks.

  19. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    DEFF Research Database (Denmark)

    Luczak, Marcin; Manzato, Simone; Peeters, Bart;

    2014-01-01

    of model parameters was selected for the model updating process. Design of experiment and response surface method was implemented to find values of model parameters yielding results closest to the experimental. The updated finite element model is producing results more consistent with the measurement...... is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations...... were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set...

  20. Global high resolution versus Limited Area Model climate change projections over Europe: quantifying confidence level from PRUDENCE results

    Energy Technology Data Exchange (ETDEWEB)

    Deque, M. [Centre National de Recherches Meteorologiques, Meteo-France, Toulouse Cedex 01 (France); Jones, R.G.; Hassell, D.C. [Hadley Centre for Climate Prediction and Research, Met Office, Devon (United Kingdom); Wild, M.; Vidale, P.L. [Swiss Federal Institute of Technology, Institute for Atmospheric and Climate Science, ETH, Zurich (Switzerland); Giorgi, F.; Kucharski, F. [Abdus Salam International Centre for Theoretical Physics, Trieste (Italy); Christensen, J.H. [Danish Meteorological Institute, Copenhagen (Denmark); Rockel, B. [Institute of Coastal Research, GKSS Forschungszentrum Geesthacht GmbH, Geesthacht (Germany); Jacob, D. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany); Kjellstroem, E. [Swedish Meteorological and Hydrological Institute, Norrkoeping (Sweden); Castro, M. de. [Universidad de Castilla La Mancha, Dept. de Ciencias Ambientales, Toledo (Spain); Hurk, B. van den [KNMI, Postbus 201, AE De Bilt (Netherlands)

    2005-11-01

    Four high resolution atmospheric general circulation models (GCMs) have been integrated with the standard forcings of the PRUDENCE experiment: IPCC-SRES A2 radiative forcing and Hadley Centre sea surface temperature and sea-ice extent. The response over Europe, calculated as the difference between the 2071-2100 and the 1961-1990 means is compared with the same diagnostic obtained with nine Regional Climate Models (RCM) all driven by the Hadley Centre atmospheric GCM. The seasonal mean response for 2m temperature and precipitation is investigated. For temperature, GCMs and RCMs behave similarly, except that GCMs exhibit a larger spread. However, during summer, the spread of the RCMs - in particular in terms of precipitation - is larger than that of the GCMs. This indicates that the European summer climate is strongly controlled by parameterized physics and/or high-resolution processes. The temperature response is larger than the systematic error. The situation is different for precipitation. The model bias is twice as large as the climate response. The confidence in PRUDENCE results comes from the fact that the models have a similar response to the IPCC-SRES A2 forcing, whereas their systematic errors are more spread. In addition, GCM precipitation response is slightly but significantly different from that of the RCMs. (orig.)

  1. A new procedure to built a model covariance matrix: first results

    Science.gov (United States)

    Barzaghi, R.; Marotta, A. M.; Splendore, R.; Borghi, A.

    2012-04-01

    In order to validate the results of geophysical models a common procedure is to compare model predictions with observations by means of statistical tests. A limit of this approach is the lack of a covariance matrix associated to model results, that may frustrate the achievement of a confident statistical significance of the results. Trying to overcome this limit, we have implemented a new procedure to build a model covariance matrix that could allow a more reliable statistical analysis. This procedure has been developed in the frame of the thermo-mechanical model described in Splendore et al. (2010), that predicts the present-day crustal velocity field in the Tyrrhenian due to Africa-Eurasia convergence and to lateral rheological heterogeneities of the lithosphere. Modelled tectonic velocity field has been compared to the available surface velocity field based on GPS observation, determining the best fit model and the degree of fitting, through the use of a χ2 test. Once we have identified the key models parameters and defined their appropriate ranges of variability, we have run 100 different models for 100 sets of randomly values of the parameters extracted within the corresponding interval, obtaining a stack of 100 velocity fields. Then, we calculated variance and empirical covariance for the stack of results, taking into account also cross-correlation, obtaining a positive defined, diagonal matrix that represents the covariance matrix of the model. This empirical approach allows us to define a more robust statistical analysis with respect the classic approach. Reference Splendore, Marotta, Barzaghi, Borghi and Cannizzaro, 2010. Block model versus thermomechanical model: new insights on the present-day regional deformation in the surroundings of the Calabrian Arc. In: Spalla, Marotta and Gosso (Eds) Advances in Interpretation of Geological Processes: Refinement of Multi scale Data and Integration in Numerical Modelling. Geological Society, London, Special

  2. Evaluating Direct Radiative Effects of Absorbing Aerosols on Atmospheric Dynamics with Aquaplanet and Regional Model Results

    Science.gov (United States)

    Can, Ö.; Tegen, I.; Quaas, J.

    2015-12-01

    Effects of absorbing aerosol on atmospheric dynamics are usually investigated with help of general circulation models or also regional models that represent the atmospheric system as realistic as possible. Reducing the complexity of models used to study the effects of absorbing aerosol on atmospheric dynamics helps to understand underlying mechanisms. In this study, by using ECHAM6 General Circulation Model (GCM) in an Aquaplanet setting and using simplified aerosol climatology, an initial idealization step has been taken. The analysis only considers direct radiative effects, furthering the reduction of complex model results. The simulations include cases including aerosol radiative forcing, no aerosol forcing, coarse mode aerosol forcing only (as approximation for mineral dust forcing) and forcing with increased aerosol absorption. The results showed that increased absorption affects cloud cover mainly in subtropics. Hadley circulation is found to be weakened in the increased absorption case. To compare the results of the idealized model with a more realistic model setting, the results of the regional model COSMO-MUSCAT that includes interactive mineral dust aerosol and considers the effects of dust radiative forcing are also analyzed. The regional model computes the atmospheric circulation for the year 2007 twice, including the feedback of dust and excluding the dust aerosol forcing. It is investigated to which extent the atmospheric response to the dust forcing agrees with the simplified Aquaplanet results. As expected, in the regional model mineral dust causes an increase in the temperature right above the dust layer while reducing the temperature close to the surface. In both models the presence of aerosol forcing leads to increased specific humidity, close to ITCZ. Notwithstanding the difference magnitudes, comparisons of the global aquaplanet and the regional model showed similar patterns. Further detailed comparisons will be presented.

  3. Weight lifting can facilitate appreciative comprehension for museum exhibits

    Directory of Open Access Journals (Sweden)

    Yuki eYamada

    2014-04-01

    Full Text Available Appreciation of exhibits in a museum can be equated to a virtual experience of lives in the contexts originally surrounding the exhibits. Here we focus on the importance of weight information, and hence tested whether experiencing a weight during museum exhibit appreciation affects the beholders’ satisfaction and recognition memory for the exhibits. An experiment was performed at a museum exhibiting skeletal preparations of animals. We used nine preparations and prepared four weight stimuli as weight cues in accordance with the actual weight of four of the preparations: Remaining five preparations was displayed without weight stimuli. In the cued condition, participants were asked to lift up the weight stimuli during their observation of the four exhibits. In the uncued condition, participants observed the exhibits without touching the weight stimuli. After observation of the exhibits, the participants responded to a questionnaire that measured their impressions of the exhibits and the museum, and performed a recognition test on the exhibits. Results showed that memory performance was better and viewing duration was longer with weight lifting instruction than without instruction. A factor analysis on the questionnaires revealed four factors (likeability, contentment, value, and quality. A path analysis showed indirect effects of viewing duration on memory performance and willingness-to-pay for the museum appreciation through the impression factors. Our findings provide insight into a new interactive exhibition that enables long appreciation producing positive effects on visitors’ impression, memory, and value estimation for exhibits.

  4. Models of convection-driven tectonic plates - A comparison of methods and results

    Science.gov (United States)

    King, Scott D.; Gable, Carl W.; Weinstein, Stuart A.

    1992-01-01

    Recent numerical studies of convection in the earth's mantle have included various features of plate tectonics. This paper describes three methods of modeling plates: through material properties, through force balance, and through a thin power-law sheet approximation. The results obtained are compared using each method on a series of simple calculations. From these results, scaling relations between the different parameterizations are developed. While each method produces different degrees of deformation within the surface plate, the surface heat flux and average plate velocity agree to within a few percent. The main results are not dependent upon the plate modeling method and herefore are representative of the physical system modeled.

  5. Binary logistic regression-Instrument for assessing museum indoor air impact on exhibits.

    Science.gov (United States)

    Bucur, Elena; Danet, Andrei Florin; Lehr, Carol Blaziu; Lehr, Elena; Nita-Lazar, Mihai

    2017-04-01

    This paper presents a new way to assess the environmental impact on historical artifacts using binary logistic regression. The prediction of the impact on the exhibits during certain pollution scenarios (environmental impact) was calculated by a mathematical model based on the binary logistic regression; it allows the identification of those environmental parameters from a multitude of possible parameters with a significant impact on exhibitions and ranks them according to their severity effect. Air quality (NO2, SO2, O3 and PM2.5) and microclimate parameters (temperature, humidity) monitoring data from a case study conducted within exhibition and storage spaces of the Romanian National Aviation Museum Bucharest have been used for developing and validating the binary logistic regression method and the mathematical model. The logistic regression analysis was used on 794 data combinations (715 to develop of the model and 79 to validate it) by a Statistical Package for Social Sciences (SPSS 20.0). The results from the binary logistic regression analysis demonstrated that from six parameters taken into consideration, four of them present a significant effect upon exhibits in the following order: O3>PM2.5>NO2>humidity followed at a significant distance by the effects of SO2 and temperature. The mathematical model, developed in this study, correctly predicted 95.1 % of the cumulated effect of the environmental parameters upon the exhibits. Moreover, this model could also be used in the decisional process regarding the preventive preservation measures that should be implemented within the exhibition space.

  6. Dermal uptake of phthalates from clothing: comparison of model to human participant results

    DEFF Research Database (Denmark)

    Morrison, Glenn; Weschler, Charles J.; Bekö, Gabriel

    2016-01-01

    In this research, we extend a model of transdermal uptake of phthalates to include a layer of clothing. When compared with experimental results, this model better estimates dermal uptake of diethylphthalate (DEP) and di-n-butylphthalate (DnBP) than a previous model. It also demonstrates that upta...... the cotton-phthalate system will be challenging until data on partition coefficients are quantified for other combinations of SVOCs, fabric materials and environmental conditions....

  7. A Three-Dimensional Babcock-Leighton Solar Dynamo Model: Initial Results with Axisymmetric Flows

    CERN Document Server

    Miesch, Mark S

    2015-01-01

    The main objective of this paper is to introduce the STABLE (Surface flux Transport And Babcock-LEighton) solar dynamo model. STABLE is a 3D Babcock-Leighton/Flux Transport dynamo model in which the source of poloidal field is the explicit emergence, distortion, and dispersal of bipolar magnetic regions (BMRs). Here we describe the STABLE model in more detail than we have previously and we verify it by reproducing a 2D mean-field benchmark. We also present some representative dynamo simulations, focusing on the special case of kinematic magnetic induction and axisymmetric flow fields. Not all solutions are supercritical; it can be a challenge for the BL mechanism to sustain the dynamo when the turbulent diffusion near the surface is $\\geq 10^{12}$ cm$^2$ s$^{-1}$. However, if BMRs are sufficiently large, deep, and numerous, then sustained, cyclic, dynamo solutions can be found that exhibit solar-like features. Furthermore, we find that the shearing of radial magnetic flux by the surface differential rotation ...

  8. A three-dimensional Babcock-Leighton solar dynamo model: Initial results with axisymmetric flows

    Science.gov (United States)

    Miesch, Mark S.; Teweldebirhan, Kinfe

    2016-10-01

    The main objective of this paper is to introduce the STABLE (Surface flux Transport And Babcock-LEighton) solar dynamo model. STABLE is a 3D Babcock-Leighton/Flux Transport dynamo model in which the source of poloidal field is the explicit emergence, distortion, and dispersal of bipolar magnetic regions (BMRs). Here we describe the STABLE model in more detail than we have previously and we verify it by reproducing a 2D mean-field benchmark. We also present some representative dynamo simulations, focusing on the special case of kinematic magnetic induction and axisymmetric flow fields. Not all solutions are supercritical; it can be a challenge for the BL mechanism to sustain the dynamo when the turbulent diffusion near the surface is ⩾ 1012 cm2 s-1. However, if BMRs are sufficiently large, deep, and numerous, then sustained, cyclic, dynamo solutions can be found that exhibit solar-like features. Furthermore, we find that the shearing of radial magnetic flux by the surface differential rotation can account for most of the net toroidal flux generation in each hemisphere, as has been recently argued for the Sun by Cameron and Schüssler (2015).

  9. Planck intermediate results XXIX. All-sky dust modelling with Planck, IRAS, and WISE observations

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Alves, M. I. R.

    2016-01-01

    . The present work extends the DL dust modelling carried out on nearby galaxies using Herschel and Spitzer data to Galactic dust emission. We employ the DL dust model to generate maps of the dust mass surface density Sigma(Md), the dust optical extinction A(V), and the starlight intensity heating the bulk......We present all-sky modelling of the high resolution Planck, IRAS, andWISE infrared (IR) observations using the physical dust model presented by Draine & Li in 2007 (DL, ApJ, 657, 810). We study the performance and results of this model, and discuss implications for future dust modelling...... of the dust, parametrized by U-min. The DL model reproduces the observed spectral energy distribution (SED) satisfactorily over most of the sky, with small deviations in the inner Galactic disk and in low ecliptic latitude areas, presumably due to zodiacal light contamination. In the Andromeda galaxy (M31...

  10. Admission Laboratory Results to Enhance Prediction Models of Postdischarge Outcomes in Cardiac Care.

    Science.gov (United States)

    Pine, Michael; Fry, Donald E; Hannan, Edward L; Naessens, James M; Whitman, Kay; Reband, Agnes; Qian, Feng; Schindler, Joseph; Sonneborn, Mark; Roland, Jaclyn; Hyde, Linda; Dennison, Barbara A

    Predictive modeling for postdischarge outcomes of inpatient care has been suboptimal. This study evaluated whether admission numerical laboratory data added to administrative models from New York and Minnesota hospitals would enhance the prediction accuracy for 90-day postdischarge deaths without readmission (PD-90) and 90-day readmissions (RA-90) following inpatient care for cardiac patients. Risk-adjustment models for the prediction of PD-90 and RA-90 were designed for acute myocardial infarction, percutaneous cardiac intervention, coronary artery bypass grafting, and congestive heart failure. Models were derived from hospital claims data and were then enhanced with admission laboratory predictive results. Case-level discrimination, goodness of fit, and calibration were used to compare administrative models (ADM) and laboratory predictive models (LAB). LAB models for the prediction of PD-90 were modestly enhanced over ADM, but negligible benefit was seen for RA-90. A consistent predictor of PD-90 and RA-90 was prolonged length of stay outliers from the index hospitalization.

  11. GENERAL APROACH TO MODELING NONLINEAR AMPLITUDE AND FREQUENCY DEPENDENT HYSTERESIS EFFECTS BASED ON EXPERIMENTAL RESULTS

    Directory of Open Access Journals (Sweden)

    Christopher Heine

    2014-08-01

    Full Text Available A detailed description of the rubber parts’ properties is gaining in importance in the current simulation models of multi-body simulation. One application example is a multi-body simulation of the washing machine movement. Inside the washing machine, there are different force transmission elements, which consist completely or partly of rubber. Rubber parts or, generally, elastomers usually have amplitude-dependant and frequency-dependent force transmission properties. Rheological models are used to describe these properties. A method for characterization of the amplitude and frequency dependence of such a rheological model is presented within this paper. Within this method, the used rheological model can be reduced or expanded in order to illustrate various non-linear effects. An original result is given with the automated parameter identification. It is fully implemented in Matlab. Such identified rheological models are intended for subsequent implementation in a multi-body model. This allows a significant enhancement of the overall model quality.

  12. Results and Comparison from the SAM Linear Fresnel Technology Performance Model: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, M. J.

    2012-04-01

    This paper presents the new Linear Fresnel technology performance model in NREL's System Advisor Model. The model predicts the financial and technical performance of direct-steam-generation Linear Fresnel power plants, and can be used to analyze a range of system configurations. This paper presents a brief discussion of the model formulation and motivation, and provides extensive discussion of the model performance and financial results. The Linear Fresnel technology is also compared to other concentrating solar power technologies in both qualitative and quantitative measures. The Linear Fresnel model - developed in conjunction with the Electric Power Research Institute - provides users with the ability to model a variety of solar field layouts, fossil backup configurations, thermal receiver designs, and steam generation conditions. This flexibility aims to encompass current market solutions for the DSG Linear Fresnel technology, which is seeing increasing exposure in fossil plant augmentation and stand-alone power generation applications.

  13. Integrating Domain Knowledge Differences into Modeling User Clicks on Search Result Pages

    NARCIS (Netherlands)

    Karanam, S.; van Oostendorp, H.

    2016-01-01

    Computational cognitive models developed so far do not incorporate any effect of individual differences in domain knowledge of users in predicting user clicks on search result pages. We address this problem using a cognitive model of information search which enables us to use two semantic spaces

  14. Modelling of water potential and water uptake rate of tomato plants in the greenhouse: preliminary results.

    NARCIS (Netherlands)

    Bruggink, G.T.; Schouwink, H.E.; Gieling, Th.H.

    1988-01-01

    A dynamic model is presented which predicts water potential and water uptake rate of greenhouse tomato plants using transpiration rate as input. The model assumes that water uptake is the resultant of water potential and hydraulic resistance, and that water potential is linearly related to water con

  15. The European Integrated Tokamak Modelling (ITM) effort: achievements and first physics results

    NARCIS (Netherlands)

    G.L. Falchetto,; Coster, D.; Coelho, R.; Scott, B. D.; Figini, L.; Kalupin, D.; Nardon, E.; Nowak, S.; L.L. Alves,; Artaud, J. F.; Basiuk, V.; João P.S. Bizarro,; C. Boulbe,; Dinklage, A.; Farina, D.; B. Faugeras,; Ferreira, J.; Figueiredo, A.; Huynh, P.; Imbeaux, F.; Ivanova-Stanik, I.; Jonsson, T.; H.-J. Klingshirn,; Konz, C.; Kus, A.; Marushchenko, N. B.; Pereverzev, G.; M. Owsiak,; Poli, E.; Peysson, Y.; R. Reimer,; Signoret, J.; Sauter, O.; Stankiewicz, R.; Strand, P.; Voitsekhovitch, I.; Westerhof, E.; T. Zok,; Zwingmann, W.; ITM-TF contributors,; ASDEX Upgrade team,; JET-EFDA Contributors,

    2014-01-01

    A selection of achievements and first physics results are presented of the European Integrated Tokamak Modelling Task Force (EFDA ITM-TF) simulation framework, which aims to provide a standardized platform and an integrated modelling suite of validated numerical codes for the simulation and

  16. Conceptual Incoherence as a Result of the Use of Multiple Historical Models in School Textbooks

    Science.gov (United States)

    Gericke, Niklas M.; Hagberg, Mariana

    2010-01-01

    This paper explores the occurrence of conceptual incoherence in upper secondary school textbooks resulting from the use of multiple historical models. Swedish biology and chemistry textbooks, as well as a selection of books from English speaking countries, were examined. The purpose of the study was to identify which models are used to represent…

  17. AFSC/RACE/GAP/Laman: Model Results of Aleutian Island POP distributions

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data supporting the "Model Results of Aleutian Island POP distributions" manuscript are distribution and abundance of Pacific ocean perch from RACEBase,...

  18. Results of a modeling workshop concerning development of the Beluga coal resource in Alaska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the results of a modeling workshop concerning development of the Beluga coal resource in Alaska. The workshop was facilitated by the AEA Group...

  19. Removal of arsenic from wastewaters by cryptocrystalline magnesite: complimenting experimental results with modelling

    CSIR Research Space (South Africa)

    Masindi, Vhahangwele

    2016-02-01

    Full Text Available -1 Journal of Cleaner Production Removal of arsenic from wastewaters by cryptocrystalline magnesite: complimenting experimental results with modelling Vhahangwele Masindi W. Mugera Gitari Keywords: Arsenic Mine leachates Cryptocrystalline...

  20. Experimental and modelling results of a parallel-plate based active magnetic regenerator

    DEFF Research Database (Denmark)

    Tura, A.; Nielsen, Kaspar Kirstein; Rowe, A.

    2012-01-01

    The performance of a permanent magnet magnetic refrigerator (PMMR) using gadolinium parallel plates is described. The configuration and operating parameters are described in detail. Experimental results are compared to simulations using an established twodimensional model of an active magnetic...

  1. Mars in their eyes - a cartoon exhibition

    Science.gov (United States)

    Pillinger, Pi.

    Recently a collection of 120 cartoons which tell the story of Mars exploration and scientific discovery, past, present and future, was held in London. We discuss the aims of the exhibition, to what extent we believe the original aims were met and report on additional outreach opportunities resulting from the project. The overriding aim was to capitalise on the popular appeal of accessible art - most people admit to enjoying cartoons. This was strengthened by hanging the originals of cartoons which had, mostly, been published in newspapers and magazines in a wide selection of countries. The provenances served to indicate the attraction of Mars to a wide public. We were fortunate to work with the Cartoon Art Trust of the UK who was in the process of relocating to new premises and opening as The Cartoon Museum, in the tourist area of Bloomsbury, central London, very close to the British Museum. "Mars in their Eyes" ran for 10 weeks during April to July 2006; immediately following which a selection of the cartoons was displayed at the week-long Royal Society Summer Exhibition. We explore the differences between the two exhibitions and comment on the various audience responses. We use this comparison to discuss whether a project which is primarily art can be extended to explain science. Does the coupling merely result in dumbing-down of both cultures or is there a true synergy? The experience has led us to coin the phrase "extreme outreach". Projects which are as ambitious as "Mars in their Eyes", without the security of a safe, captive audience, for example at a Science Centre, must be judged by different criteria. Indeed if the project does not meet comparable targets like large visitor numbers, then the honest evaluation of such details can only inform future activities and must not be reflected in the future funding of only "safe" outreach activities.

  2. Digital Natives: Creating Emergent Exhibitions through Digital Technologies

    DEFF Research Database (Denmark)

    Smith, Rachel Charlotte; Iversen, Ole Sejer; Dindler, Christian

    2011-01-01

    Digital Technology can support the creation of dialogical spaces in the museum, both playful and reflective, that allow audiences to engage in the ongoing construction and reproduction of cultural heritage creating novel connections between self and others and between past, present and future....... In this way, digital technology can contribute to the creation of emergent exhibitions in which the exhibition is created in dialogue between audiences and the museum. We present experiences from a current research project, the Digital Natives exhibition, in which digital technology was designed...... as an integral part of the exhibition to encourage dialogue between audiences and the exhibition materials and thereby investigate how the exhibition emerge as a result of this dialogic co-construction inside the exhibition space. In short, the opportunities offered by digital technologies prompts us to consider...

  3. Study the Effect of Sources of Manufacturing Companies on the Achievement of the Objectives of the Trade Exhibition: Case Study at the International Exhibition of Bushehr City

    Directory of Open Access Journals (Sweden)

    Majid Esmaeilpour

    2016-01-01

    Full Text Available Background: With increasing competition and reducing the possibility of exposure to commodities, the possibility of participating in trade exhibition is important hundredfold. Exhibiting a great opportunity for companies provide the goods. The exhibition will present a pre-determined targets and long-term planning to achieve these goals, the recognition of its resources in setting goals as a fundamental principle of the company, is participating in the exhibition. Objectives: The purpose of this study was to assess the importance sources of participating in trade exhibition and the impact that it will have sources of to achieve the objectives of the exhibition. Methodology: The study in term of purpose is applied and in term of data collection is descriptive - and the correlation. The research includes companies participating in international exhibition Bushehr over 180 companies. This study used a sample of 120 companies was Morgan. Data derived from the survey questionnaire. Validity through the content validity and reliability through Cronbach's alpha was approved. Data Analysis is a method of structural equation modeling. Results and findings: The results obtained suggest that the booth personnel sources of, sources of exhibition have a significant impact on sales targets and management capabilities. The booth personnel sources of and the ability to communicate with customers also have a significant impact on sales purposes. The findings of this study it can be concluded that except for the purposes of sale and non-sale capabilities partnership that does not, improvement of existing resources and capabilities of each model achieves sales targets and other participants will sell.

  4. User's guide to Model Viewer, a program for three-dimensional visualization of ground-water model results

    Science.gov (United States)

    Hsieh, Paul A.; Winston, Richard B.

    2002-01-01

    Model Viewer is a computer program that displays the results of three-dimensional groundwater models. Scalar data (such as hydraulic head or solute concentration) may be displayed as a solid or a set of isosurfaces, using a red-to-blue color spectrum to represent a range of scalar values. Vector data (such as velocity or specific discharge) are represented by lines oriented to the vector direction and scaled to the vector magnitude. Model Viewer can also display pathlines, cells or nodes that represent model features such as streams and wells, and auxiliary graphic objects such as grid lines and coordinate axes. Users may crop the model grid in different orientations to examine the interior structure of the data. For transient simulations, Model Viewer can animate the time evolution of the simulated quantities. The current version (1.0) of Model Viewer runs on Microsoft Windows 95, 98, NT and 2000 operating systems, and supports the following models: MODFLOW-2000, MODFLOW-2000 with the Ground-Water Transport Process, MODFLOW-96, MOC3D (Version 3.5), MODPATH, MT3DMS, and SUTRA (Version 2D3D.1). Model Viewer is designed to directly read input and output files from these models, thus minimizing the need for additional postprocessing. This report provides an overview of Model Viewer. Complete instructions on how to use the software are provided in the on-line help pages.

  5. Updating the CHAOS series of field models using Swarm data and resulting candidate models for IGRF-12

    DEFF Research Database (Denmark)

    Finlay, Chris; Olsen, Nils; Tøffner-Clausen, Lars

    th order spline representation with knot points spaced at 0.5 year intervals. The resulting field model is able to consistently fit data from six independent low Earth orbit satellites: Oersted, CHAMP, SAC-C and the three Swarm satellites. As an example, we present comparisons of the excellent model......Ten months of data from ESA's Swarm mission, together with recent ground observatory monthly means, are used to update the CHAOS series of geomagnetic field models with a focus on time-changes of the core field. As for previous CHAOS field models quiet-time, night-side, data selection criteria...

  6. The comparison of measured impedance of the bladder tissue with the computational modeling results

    Directory of Open Access Journals (Sweden)

    ahmad keshtkar

    2015-11-01

    Full Text Available Introduction: The electrical impedance spectroscopy technique can be used to measure the electrical impedance of the human bladder tissue, for differentiating pathological changes in the urothelium. Methods: In this study, the electrical impedance spectroscopy technique and then, a numerical technique, finite element analysis (FEA were used to model the electrical properties of this tissue to predict the impedance spectrum of the normal and malignant areas of this organ. Results: After determining and comparing the modeled data with the experimental results, it is believed that there are some factors that may affect the measurement results. Thus, the effect of inflammation, edema, changes in the applied pressure over the probe and the distensible property of the bladder tissue were considered. Furthermore, the current distribution inside the human bladder tissue was modeled in normal and malignant cases using the FEA. This model results showed that very little of the current actually flows through the urothelium and much of the injected current flows through the connective tissue beneath the urothelium. Conclusion: The results of the models do not explain the measurements results. In conclusion, there are many factors, which may account for discrepancies between the measured and modeled data.

  7. New Results on Robust Model Predictive Control for Time-Delay Systems with Input Constraints

    Directory of Open Access Journals (Sweden)

    Qing Lu

    2014-01-01

    Full Text Available This paper investigates the problem of model predictive control for a class of nonlinear systems subject to state delays and input constraints. The time-varying delay is considered with both upper and lower bounds. A new model is proposed to approximate the delay. And the uncertainty is polytopic type. For the state-feedback MPC design objective, we formulate an optimization problem. Under model transformation, a new model predictive controller is designed such that the robust asymptotical stability of the closed-loop system can be guaranteed. Finally, the applicability of the presented results are demonstrated by a practical example.

  8. The Exhibition Performance Appraisal Index System Based on Stakeholder Theory

    Institute of Scientific and Technical Information of China (English)

    YAN Shu-min; HAO Qi-hui

    2009-01-01

    Exhibition performance should be evaluated from different perspectives of stakeholders. The benefits of each stakeholder can not be satisfied when evaluating the exhibition performance from a single perspective or. only evaluating the economic performance of the exhibition. In this paper, the stakeholders are defined on the basis of questionnaire investigation and classified by mathematical statistical method. According to the requirements of the stakeholders, the exhibition performance appraisal indicators are extracted and, simplified by factor analysis, which leads to the formation of a set of performance appraisal index system. It is an instructive attempt to work out the exhibition performance appraisal model from the perspective of stakeholders, which may provide theoretical foundation and practice instruction for exhibition performance appraisal in our country.

  9. Effects of Subscale Size and Shape on Global Energy Dissipation in a Multiscale Model of a Fiber-Reinforced Composite Exhibiting Post-Peak Strain Softening Using Abaqus and FEAMAC

    Science.gov (United States)

    Pineda, Evan, J.; Bednarcyk, Brett, A.; Arnold, Steven, M.

    2012-01-01

    A mesh objective crack band model is implemented in the generalized method of cells (GMC) micromechanics model to predict failure of a composite repeating unit cell (RUC). The micromechanics calculations are achieved using the MAC/GMC core engine within the ImMAC suite of micromechanics codes, developed at the NASA Glenn Research Center. The microscale RUC is linked to a macroscale Abaqus/Standard finite element model using the FEAMAC multiscale framework (included in the ImMAC suite). The effects of the relationship between the characteristic length of the finite element and the size of the microscale RUC on the total energy dissipation of the multiscale model are investigated. A simple 2-D composite square subjected to uniaxial tension is used to demonstrate the effects of scaling the dimensions of the RUC such that the length of the sides of the RUC are equal to the characteristic length of the finite element. These results are compared to simulations where the size of the RUC is fixed, independent of the element size. Simulations are carried out for a variety of mesh densities and element shapes, including square and triangular. Results indicate that a consistent size and shape must be used to yield preserve energy dissipation across the scales.

  10. Ketogenic diet exhibits anti-inflammatory properties.

    Science.gov (United States)

    Dupuis, Nina; Curatolo, Niccolo; Benoist, Jean-François; Auvin, Stéphane

    2015-07-01

    The ketogenic diet (KD) is an established treatment for refractory epilepsy, including some inflammation-induced epileptic encephalopathies. In a lipopolysaccharide (LPS)-induced fever model in rats, we found that animals given the KD for 14 days showed less fever and lower proinflammatory cytokine levels than control animals. However, KD rats exhibited a decrease in circulating levels of arachidonic acid and long-chain n-3 polyunsaturated fatty acids (PUFAs), suggesting that the anti-inflammatory effect of KD was probably not due to an increase in anti-inflammatory n-3 PUFA derivatives. These properties might be of interest in some conditions such as fever-induced refractory epileptic encephalopathy in school-aged children.

  11. Theoretical results on the tandem junction solar cell based on its Ebers-Moll transistor model

    Science.gov (United States)

    Goradia, C.; Vaughn, J.; Baraona, C. R.

    1980-01-01

    A one-dimensional theoretical model of the tandem junction solar cell (TJC) with base resistivity greater than about 1 ohm-cm and under low level injection has been derived. This model extends a previously published conceptual model which treats the TJC as an npn transistor. The model gives theoretical expressions for each of the Ebers-Moll type currents of the illuminated TJC and allows for the calculation of the spectral response, I(sc), V(oc), FF and eta under variation of one or more of the geometrical and material parameters and 1MeV electron fluence. Results of computer calculations based on this model are presented and discussed. These results indicate that for space applications, both a high beginning of life efficiency, greater than 15% AM0, and a high radiation tolerance can be achieved only with thin (less than 50 microns) TJC's with high base resistivity (greater than 10 ohm-cm).

  12. RELATIONSHIP BETWEEN ISO 9001 CERTIFICATION MATURITY AND EFQM BUSINESS EXCELLENCE MODEL RESULTS

    Directory of Open Access Journals (Sweden)

    Luis Miguel Fonseca

    2015-07-01

    Full Text Available Purpose: This exploratory research evaluates if there a relationship between the number of years since an organization has achieved ISO 9001 certification and the highest level of recognition received by the same organization with the EFQM Business Excellence Model.Methodology/Approach: After state of the art review a detailed comparison between both models was made. Fifty two Portuguese organizations were considered and Correlation coefficient Spearman Rho was used to investigate the possible relationships.Findings: Conclusion is that there is indeed a moderate positive correlation between these two variables, the higher the number of years of ISO 9001 certification, the higher the results of the organization EFQM model evaluation and recognition. This supports the assumption that ISO 9001 International Standard by incorporating many of the principles present in the EFQM Business Excellence Model is consistent with this model and can be considered as a step towards that direction.Research Limitation/implication: Due to the dynamic nature of these models that might change over time and the possible time delays between implementation and results, more in-depth studies like experimental design or a longitudinal quasi-experimental design could be used to confirm the results of this investigation.Originality/Value of paper: This research gives additional insights on conjunct studies of both models. The use of external evaluation results carried out by the independent EFQM assessors minimizes the possible bias of previous studies accessing the value of ISO 9001 certification.

  13. Report on Exhibition Industry in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ 1. General Characteristics of Shanghai Exhibitions As the leader of economic development in the Yangtze River Delta,Shanghai has basically formed a certain scale and strength in the aspects of urban transportation, exhibition venues, supporting facilities, service levels, etc.

  14. Early Results from a Multi-Thermal Model for the Cooling of Post-Flare Loops

    Science.gov (United States)

    Reeves, K. K.; Warren, H. P.

    2002-01-01

    We have developed a multi-thermal model for the cooling of post-flare loops. The model consists of an arcade of many nested loops that reconnect and begin cooling at slightly different times, and have different cooling profiles because of the different loop lengths across the arcade. Cooling due to both conductive and radiative processes is taken into account. The free parameters in the model include initial temperature and density in the loop, loop width and the initial loop length. The results from the model are then compared to TRACE and SXT observations. Our many-loop model does a much better job of predicting the SXT and TRACE light curves than a similar model with only one loop.

  15. NACA 0012 benchmark model experimental flutter results with unsteady pressure distributions

    Science.gov (United States)

    Rivera, Jose A., Jr.; Dansberry, Bryan E.; Bennett, Robert M.; Durham, Michael H.; Silva, Walter A.

    1992-01-01

    The Structural Dynamics Division at NASA Langley Research Center has started a wind tunnel activity referred to as the Benchmark Models Program. The primary objective of the program is to acquire measured dynamic instability and corresponding pressure data that will be useful for developing and evaluating aeroelastic type CFD codes currently in use or under development. The program is a multi-year activity that will involve testing of several different models to investigate various aeroelastic phenomena. This paper describes results obtained from a second wind tunnel test of the first model in the Benchmark Models Program. This first model consisted of a rigid semispan wing having a rectangular planform and a NACA 0012 airfoil shape which was mounted on a flexible two degree-of-freedom mount system. Experimental flutter boundaries and corresponding unsteady pressure distribution data acquired over two model chords located at the 60 and 95 percent span stations are presented.

  16. Environmental Model Interoperability Enabled by Open Geospatial Standards - Results of a Feasibility Study (Invited)

    Science.gov (United States)

    Benedict, K. K.; Yang, C.; Huang, Q.

    2010-12-01

    The availability of high-speed research networks such as the US National Lambda Rail and the GÉANT network, scalable on-demand commodity computing resources provided by public and private "cloud" computing systems, and increasing demand for rapid access to the products of environmental models for both research and public policy development contribute to a growing need for the evaluation and development of environmental modeling systems that distribute processing, storage, and data delivery capabilities between network connected systems. In an effort to address the feasibility of developing a standards-based distributed modeling system in which model execution systems are physically separate from data storage and delivery systems, the research project presented in this paper developed a distributed dust forecasting system in which two nested atmospheric dust models are executed at George Mason University (GMU, in Fairfax, VA) while data and model output processing services are hosted at the University of New Mexico (UNM, in Albuquerque, NM). Exchange of model initialization and boundary condition parameters between the servers at UNM and the model execution systems at GMU is accomplished through Open Geospatial Consortium (OGC) Web Coverage Services (WCS) and Web Feature Services (WFS) while model outputs are pushed from GMU systems back to UNM using a REST web service interface. In addition to OGC and non-OGC web services for exchange between UNM and GMU, the servers at UNM also provide access to the input meteorological model products, intermediate and final dust model outputs, and other products derived from model outputs through OGC WCS, WFS, and OGC Web Map Services (WMS). The performance of the nested versus non-nested models is assessed in this research, with the results of the performance analysis providing the core content of the produced feasibility study. System integration diagram illustrating the storage and service platforms hosted at the Earth Data

  17. A Nuclear Interaction Model for Understanding Results of Single Event Testing with High Energy Protons

    Science.gov (United States)

    Culpepper, William X.; ONeill, Pat; Nicholson, Leonard L.

    2000-01-01

    An internuclear cascade and evaporation model has been adapted to estimate the LET spectrum generated during testing with 200 MeV protons. The model-generated heavy ion LET spectrum is compared to the heavy ion LET spectrum seen on orbit. This comparison is the basis for predicting single event failure rates from heavy ions using results from a single proton test. Of equal importance, this spectra comparison also establishes an estimate of the risk of encountering a failure mode on orbit that was not detected during proton testing. Verification of the general results of the model is presented based on experiments, individual part test results, and flight data. Acceptance of this model and its estimate of remaining risk opens the hardware verification philosophy to the consideration of radiation testing with high energy protons at the board and box level instead of the more standard method of individual part testing with low energy heavy ions.

  18. A Tower Model for Lightning Overvoltage Studies Based on the Result of an FDTD Simulation

    Science.gov (United States)

    Noda, Taku

    This paper describes a method for deriving a transmission tower model for EMTP lightning overvoltage studies from a numerical electromagnetic simulation result obtained by the FDTD (Finite Difference Time Domain) method. The FDTD simulation carried out in this paper takes into account the following items which have been ignored or over-simplified in previously-presented simulations: (i) resistivity of the ground soil; (ii) arms, major slant elements, and foundations of the tower; (iii) development speed of the lightning return stroke. For validation purpose a pulse test of a 500-kV transmission tower is simulated, and a comparison with the measured result shows that the present FDTD simulation gives a sufficiently accurate result. Using this validated FDTD-based simulation method the insulator-string voltages of a tower for a lightning stroke are calculated, and based on the simulation result the parameter values of the proposed tower model for EMTP studies are determined in a systematic way. Since previously-presented models include trial-and-error process in the parameter determination, it can be said that the proposed model is more general in this regard. As an illustrative example, the 500-kV transmission tower mentioned above is modeled, and it is shown that the derived model closely reproduces the FDTD simulation result.

  19. Construction of an extended library of adult male 3D models: rationale and results

    Science.gov (United States)

    Broggio, D.; Beurrier, J.; Bremaud, M.; Desbrée, A.; Farah, J.; Huet, C.; Franck, D.

    2011-12-01

    In order to best cover the possible extent of heights and weights of male adults the construction of 25 whole body 3D models has been undertaken. Such a library is thought to be useful to specify the uncertainties and relevance of dosimetry calculations carried out with models representing individuals of average body heights and weights. Representative 3D models of Caucasian body types are selected in a commercial database according to their height and weight, and 3D models of the skeleton and internal organs are designed using another commercial dataset. A review of the literature enabled one to fix volume or mass target values for the skeleton, soft organs, skin and fat content of the selected individuals. The composition of the remainder tissue is fixed so that the weight of the voxel models equals the weight of the selected individuals. After mesh and NURBS modelling, volume adjustment of the selected body shapes and additional voxel-based work, 25 voxel models with 109 identified organs or tissue are obtained. Radiation transport calculations are carried out with some of the developed models to illustrate potential uses. The following points are discussed throughout this paper: justification of the fixed or obtained models' features regarding available and relevant literature data; workflow and strategy for major modelling steps; advantages and drawbacks of the obtained library as compared with other works. The construction hypotheses are explained and justified in detail since future calculation results obtained with this library will depend on them.

  20. Development Report on Exhibition Industry in Guangzhou

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Ⅰ. Generat Features of Guangzhou Exhibitions (Ⅰ) Quantity of Exhibitions and Industry Features. Overall, after suf-fering from global financial crisis in 2008 as well as the interference of Beijing Olympic Games and other major events, the exhibition industry in Guangzhou has still not encountered an easy condition in 2009.

  1. Beijing Lack of "Carrier"Exhibition Center

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    An Interview towards Mr. Chu Xiangyin, Vice Chairman of Beijing Subcouncil, CCPIT Reporter: Would you please tell us development of exhibition industry in Beijing? Chu Xiangyin: Beijing Statistical Bureau and us have been designing and analyzing statistical system for exhibition industry from 2003. As the largest exhibition center in Beijing,

  2. Study on the Competitiveness of Pudong Exhibition Industry Cluster in Shanghai Based on GEM Model%基于GEM模型的上海浦东会展产业集群竞争力研究

    Institute of Scientific and Technical Information of China (English)

    王尚君

    2014-01-01

    产业集群是一种新的区域发展趋势。浦东会展产业已经形成了相对完整的产业集群。在此背景下,基于GEM理论模型,依据上海浦东会展产业调查数据的分析结果,构建了上海浦东会展产业集群竞争力的指标体系,得出了各指标的权重分布;通过对各指标数值的定量分析,得出其会展产业竞争力指数,从而找到了上海浦东会展产业集群的薄弱环节,并提出了对策,以期提高竞争优势,推动上海浦东会展产业集群的进一步发展。%Industry cluster is new regional developments trends. Pudong exhibition industry has formed a relatively complete indus-trial cluster. Under the situdation, it aims to establish an index system and weight distribution of Pudong exhibition industry cluster competition accoding to GEM theory and under the analysis of the corresponding data of Pudong exhibition industry cluster competi-tion qustionare. The exhibition industry cluster competitiveness index is got in order to facilitate the understanding of the weak links of Pudong in Shanghai exhibition industry cluster through the quantitative analysis of the competitiveness level. Pudong exhibition industry cluster inadequate analysis and countermeasure is proposed in order to increase its competitive advantage, and promote the development of the exhibition industry cluster in Shanghai Pudong.

  3. Environmental enrichment for a mixed-species nocturnal mammal exhibit.

    Science.gov (United States)

    Clark, Fay E; Melfi, Vicky A

    2012-01-01

    Environmental enrichment (EE) is an integral aspect of modern zoo animal management but, empirical evaluation of it is biased toward species housed in single-species groups. Nocturnal houses, where several nocturnal species are housed together, are particularly overlooked. This study investigated whether three species (nine-banded armadillos, Dasypus novemcinctus; Senegal bush babies, Galago senegalensis; two-toed sloths, Choloepus didactylus) in the nocturnal house at Paignton Zoo Environmental Park, UK could be enriched using food-based and sensory EE. Subjects were an adult male and female of each species. EE was deemed effective if it promoted target species-typical behaviors, behavioral diversity, and increased use of enriched exhibit zones. Results from generalized linear mixed models demonstrated that food-based EE elicited the most positive behavioral effects across species. One set of food-based EEs (Kong®, termite mound and hanging food) presented together was associated with a significant increase in species-typical behaviors, increased behavioral diversity, and increased use of enriched exhibit zones in armadillos and bush babies. Although one type of sensory EE (scented pine cones) increased overall exhibit use in all species, the other (rainforest sounds) was linked to a significant decrease in species-typical behavior in bush babies and sloths. There were no intra or interspecies conflicts over EE, and commensalism occurred between armadillos and bush babies. Our data demonstrate that simple food-based and sensory EE can promote positive behavioral changes in a mixed-species nocturnal mammal exhibit. We suggest that both food and sensory EE presented concurrently will maximize opportunities for naturalistic activity in all species.

  4. DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results

    Directory of Open Access Journals (Sweden)

    Gizzatkulov Nail M

    2010-08-01

    Full Text Available Abstract Background Systems biology research and applications require creation, validation, extensive usage of mathematical models and visualization of simulation results by end-users. Our goal is to develop novel method for visualization of simulation results and implement it in simulation software package equipped with the sophisticated mathematical and computational techniques for model development, verification and parameter fitting. Results We present mathematical simulation workbench DBSolve Optimum which is significantly improved and extended successor of well known simulation software DBSolve5. Concept of "dynamic visualization" of simulation results has been developed and implemented in DBSolve Optimum. In framework of the concept graphical objects representing metabolite concentrations and reactions change their volume and shape in accordance to simulation results. This technique is applied to visualize both kinetic response of the model and dependence of its steady state on parameter. The use of the dynamic visualization is illustrated with kinetic model of the Krebs cycle. Conclusion DBSolve Optimum is a user friendly simulation software package that enables to simplify the construction, verification, analysis and visualization of kinetic models. Dynamic visualization tool implemented in the software allows user to animate simulation results and, thereby, present them in more comprehensible mode. DBSolve Optimum and built-in dynamic visualization module is free for both academic and commercial use. It can be downloaded directly from http://www.insysbio.ru.

  5. Assessing the agricultural costs of climate change: Combining results from crop and economic models

    Science.gov (United States)

    Howitt, R. E.

    2016-12-01

    simultaneously. The paper will briefly discuss some examples of the direct embedding of results from plant growth models in economic models.

  6. Exact results for spin dynamics and fractionalization in the Kitaev Model.

    Science.gov (United States)

    Baskaran, G; Mandal, Saptarshi; Shankar, R

    2007-06-15

    We present certain exact analytical results for dynamical spin correlation functions in the Kitaev Model. It is the first result of its kind in nontrivial quantum spin models. The result is also novel: in spite of the presence of gapless propagating Majorana fermion excitations, dynamical two spin correlation functions are identically zero beyond nearest neighbor separation. This shows existence of a gapless but short range spin liquid. An unusual, all energy scale fractionalization of a spin-flip quanta, into two infinitely massive pi fluxes and a dynamical Majorana fermion, is shown to occur. As the Kitaev Model exemplifies topological quantum computation, our result presents new insights into qubit dynamics and generation of topological excitations.

  7. Empirical Results of Modeling EUR/RON Exchange Rate using ARCH, GARCH, EGARCH, TARCH and PARCH models

    Directory of Open Access Journals (Sweden)

    Andreea – Cristina PETRICĂ

    2017-03-01

    Full Text Available The aim of this study consists in examining the changes in the volatility of daily returns of EUR/RON exchange rate using on the one hand symmetric GARCH models (ARCH and GARCH and on the other hand the asymmetric GARCH models (EGARCH, TARCH and PARCH, since the conditional variance is time-varying. The analysis takes into account daily quotations of EUR/RON exchange rate over the period of 04th January 1999 to 13th June 2016. Thus, we are modeling heteroscedasticity by applying different specifications of GARCH models followed by looking for significant parameters and low information criteria (minimum Akaike Information Criterion. All models are estimated using the maximum likelihood method under the assumption of several distributions of the innovation terms such as: Normal (Gaussian distribution, Student’s t distribution, Generalized Error distribution (GED, Student’s with fixed df. Distribution, and GED with fixed parameter distribution. The predominant models turned out to be EGARCH and PARCH models, and the empirical results point out that the best model for estimating daily returns of EUR/RON exchange rate is EGARCH(2,1 with Asymmetric order 2 under the assumption of Student’s t distributed innovation terms. This can be explained by the fact that in case of EGARCH model, the restriction regarding the positivity of the conditional variance is automatically satisfied.

  8. Affordances and distributed cognition in museum exhibitions

    DEFF Research Database (Denmark)

    Achiam, Marianne; May, Michael; Marandino, Martha

    2014-01-01

    consistent framework. Here, we invoke the notions of affordance and distributed cognition to explain in a coherent way how visitors interact with exhibits and exhibit spaces and make meaning from those interactions, and we exemplify our points using observations of twelve visitors to exhibits at a natural...... history museum. We show how differences in exhibit characteristics give rise to differences in the interpretive strategies used by visitors in their meaning-making process, and conclude by discussing how the notions of affordance and distributed cognition can be used in an exhibit design perspective....

  9. Satellite data for systematic validation of wave model results in the Black Sea

    Science.gov (United States)

    Behrens, Arno; Staneva, Joanna

    2017-04-01

    The Black Sea is with regard to the availability of traditional in situ wave measurements recorded by usual waverider buoys a data sparse semi-enclosed sea. The only possibility for systematic validations of wave model results in such a regional area is the use of satellite data. In the frame of the COPERNICUS Marine Evolution System for the Black Sea that requires wave predictions, the third-generation spectral wave model WAM is used. The operational system is demonstrated based on four years' systematic comparisons with satellite data. The aim of this investigation was to answer two questions. Is the wave model able to provide a reliable description of the wave conditions in the Black Sea and are the satellite measurements suitable for validation purposes on such a regional scale ? Detailed comparisons between measured data and computed model results for the Black Sea including yearly statistics have been done for about 300 satellite overflights per year. The results discussed the different verification schemes needed to review the forecasting skills of the operational system. The good agreement between measured and modeled data supports the expectation that the wave model provides reasonable results and that the satellite data is of good quality and offer an appropriate validation alternative to buoy measurements. This is the required step towards further use of those satellite data for assimilation into the wave fields to improve the wave predictions. Additional support for the good quality of the wave predictions is provided by comparisons between ADCP measurements that are available for a short time period in February 2012 and the corresponding model results at a location near the Bulgarian coast in the western Black Sea. Sensitivity tests with different wave model options and different driving wind fields have been done which identify the appropriate model configuration that provides the best wave predictions. In addition to the comparisons between measured

  10. A computer model to forecast wetland vegetation changes resulting from restoration and protection in coastal Louisiana

    Science.gov (United States)

    Visser, Jenneke M.; Duke-Sylvester, Scott M.; Carter, Jacoby; Broussard, Whitney P.

    2013-01-01

    The coastal wetlands of Louisiana are a unique ecosystem that supports a diversity of wildlife as well as a diverse community of commercial interests of both local and national importance. The state of Louisiana has established a 5-year cycle of scientific investigation to provide up-to-date information to guide future legislation and regulation aimed at preserving this critical ecosystem. Here we report on a model that projects changes in plant community distribution and composition in response to environmental conditions. This model is linked to a suite of other models and requires input from those that simulate the hydrology and morphology of coastal Louisiana. Collectively, these models are used to assess how alternative management plans may affect the wetland ecosystem through explicit spatial modeling of the physical and biological processes affected by proposed modifications to the ecosystem. We have also taken the opportunity to advance the state-of-the-art in wetland plant community modeling by using a model that is more species-based in its description of plant communities instead of one based on aggregated community types such as brackish marsh and saline marsh. The resulting model provides an increased level of ecological detail about how wetland communities are expected to respond. In addition, the output from this model provides critical inputs for estimating the effects of management on higher trophic level species though a more complete description of the shifts in habitat.

  11. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    Directory of Open Access Journals (Sweden)

    Marcin Luczak

    2014-01-01

    Full Text Available This paper presents selected results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study of the structural dynamics of a bend-twist coupled full scale section of a wind turbine blade structure. The main goal of the conducted research is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set of model parameters was selected for the model updating process. Design of experiment and response surface method was implemented to find values of model parameters yielding results closest to the experimental. The updated finite element model is producing results more consistent with the measurement outcomes.

  12. SModelS: A Tool for Making Systematic Use of Simplified Models Results

    Science.gov (United States)

    Waltenberger, Wolfgang; SModelS Group.

    2016-10-01

    We present an automated software tool ”SModelS” to systematically confront theories Beyond the Standard Model (BSM) with experimental data. The tool consists of a general procedure to decompose such BSM theories into their Simplified Models Spectra (SMS). In addition, SModelS features a database containing the majority of the published SMS results of CMS and ATLAS. These results consist of the 95% confidence level upper limits on signal production cross sections. The two components together allow us to quickly confront any BSM model with LHC results. As a show-case example we will briefly discuss an application of our procedure to a specific supersymmetric model. It is one of our ongoing efforts to extend the framework to include also efficiency maps produced either by the experimental collaborations, by efforts performed within the phenomenological groups, or possibly also by ourselves. While the current implementation can handle null results only, it is our ultimate goal to build the Next Standard Model in a bottom-up fashion from both negative and positive results of several experiments. The implementation is open source, written in python, and available from http://smodels.hephy.at.

  13. Gearbox Reliability Collaborative Phase 1 and 2: Testing and Modeling Results; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Keller, J.; Guo, Y.; LaCava, W.; Link, H.; McNiff, B.

    2012-05-01

    The Gearbox Reliability Collaborative (GRC) investigates root causes of wind turbine gearbox premature failures and validates design assumptions that affect gearbox reliability using a combined testing and modeling approach. Knowledge gained from the testing and modeling of the GRC gearboxes builds an understanding of how the selected loads and events translate into internal responses of three-point mounted gearboxes. This paper presents some testing and modeling results of the GRC research during Phase 1 and 2. Non-torque loads from the rotor including shaft bending and thrust, traditionally assumed to be uncoupled with gearbox, affect gear and bearing loads and resulting gearbox responses. Bearing clearance increases bearing loads and causes cyclic loading, which could contribute to a reduced bearing life. Including flexibilities of key drivetrain subcomponents is important in order to reproduce the measured gearbox response during the tests using modeling approaches.

  14. Results of recent Pacific-Arctic ice-ocean modeling studies at the Naval Postgraduate School

    Institute of Scientific and Technical Information of China (English)

    Jaclyn Clement Kinney; Wieslaw Maslowski

    2008-01-01

    Summary of results from a high - resolution pan - Arctic ice -'ocean model are presented for the northern North Pacific, Bering, Chukchi, and Beaufort seas.The main focus is on the mean circulation, communication from the Gulf of Alaska across the Bering Sea into the western Arctic Ocean and on mesoscale eddy activity within several important ecosystems. Model results from 1979 -2004 are compared to observations whenever possible. The high spatial model resolution at 1/12o (or~9 -km) in the horizontal and 45 levels in the vertical direction allows for representation of eddies with diameters as small as 36 km. However, we believe that upcoming new model integrations at even higher resolution will allow us to resolve even smaller eddies. This is especially important at the highest latitudes where the Rossby radius of deformation is as small as 10 km or less.

  15. Soil gas and radon entry into a simple test structure: Comparison of experimental and modelling results

    DEFF Research Database (Denmark)

    Andersen, C.E.; Søgaard-Hansen, J.; Majborn, B.

    1994-01-01

    A radon test structure has been established at a field site at Riso National Laboratory. Measurements have been made of soil gas entry rates, pressure couplings and radon depletion. The experimental results have been compared with results obtained from measured soil parameters and a two......-dimensional steady-state numerical model of Darcy flow and combined diffusive and advective transport of radon. For most probe locations, the calculated values of the pressure couplings and the radon depletion agree well with the measured values, thus verifying important elements of the Darcy flow approximation......, and the ability of the model to treat combined diffusive and advective transport of radon. However, the model gives an underestimation of the soil gas entry rate. Even if it is assumed that the soil has a permeability equal to the highest of the measured values, the model underestimates the soil gas entry rate...

  16. A Calibration of the Wierzbicki-Xue Damage Model Using Charpy Test Results

    Directory of Open Access Journals (Sweden)

    Kim Jong-Bong

    2015-01-01

    Full Text Available Damage models are frequently used to predict fractures in large deformation problems such as penetration of a projectile into a target. Though many damage models have been proposed so far, coefficients of each model have been provided for only a few materials. In this study, the coefficients of the Wierzbicki-Xue (2005 damage model for tungsten heavy alloy (DX2HCMF are determined using the Charpy impact test. The Wierzbicki-Xue fracture criterion is implemented into NET3D code in which a node-split algorithm is built in. By comparing the energy absorbed in the Charpy test with the results of finite element analysis, the fracture model coefficients are determined.

  17. Quantifying Uncertainty in Model Predictions for the Pliocene (Plio-QUMP): Initial results

    Science.gov (United States)

    Pope, J.O.; Collins, M.; Haywood, A.M.; Dowsett, H.J.; Hunter, S.J.; Lunt, D.J.; Pickering, S.J.; Pound, M.J.

    2011-01-01

    Examination of the mid-Pliocene Warm Period (mPWP; ~. 3.3 to 3.0. Ma BP) provides an excellent opportunity to test the ability of climate models to reproduce warm climate states, thereby assessing our confidence in model predictions. To do this it is necessary to relate the uncertainty in model simulations of mPWP climate to uncertainties in projections of future climate change. The uncertainties introduced by the model can be estimated through the use of a Perturbed Physics Ensemble (PPE). Developing on the UK Met Office Quantifying Uncertainty in Model Predictions (QUMP) Project, this paper presents the results from an initial investigation using the end members of a PPE in a fully coupled atmosphere-ocean model (HadCM3) running with appropriate mPWP boundary conditions. Prior work has shown that the unperturbed version of HadCM3 may underestimate mPWP sea surface temperatures at higher latitudes. Initial results indicate that neither the low sensitivity nor the high sensitivity simulations produce unequivocally improved mPWP climatology relative to the standard. Whilst the high sensitivity simulation was able to reconcile up to 6 ??C of the data/model mismatch in sea surface temperatures in the high latitudes of the Northern Hemisphere (relative to the standard simulation), it did not produce a better prediction of global vegetation than the standard simulation. Overall the low sensitivity simulation was degraded compared to the standard and high sensitivity simulations in all aspects of the data/model comparison. The results have shown that a PPE has the potential to explore weaknesses in mPWP modelling simulations which have been identified by geological proxies, but that a 'best fit' simulation will more likely come from a full ensemble in which simulations that contain the strengths of the two end member simulations shown here are combined. ?? 2011 Elsevier B.V.

  18. Coupling Landform Evolution and Soil Pedogenesis - Initial Results From the SSSPAM5D Model

    Science.gov (United States)

    Willgoose, G. R.; Welivitiya, W. D. D. P.; Hancock, G. R.; Cohen, S.

    2015-12-01

    Evolution of soil on a dynamic landform is a crucial next step in landscape evolution modelling. Some attempts have been taken such as MILESD by Vanwalleghem et al. to develop a first model which is capable of simultaneously evolving both the soil profile and the landform. In previous work we have presented physically based models for soil pedogenesis, mARM and SSSPAM. In this study we present the results of coupling a landform evolution model with our SSSPAM5D soil pedogenesis model. In previous work the SSSPAM5D soil evolution model was used to identify trends of the soil profile evolution on a static landform. Two pedogenetic processes, namely (1) armouring due to erosion, and (2) physical and chemical weathering were used in those simulations to evolve the soil profile. By incorporating elevation changes (due to erosion and deposition) we have advanced the SSSPAM5D modelling framework into the realm of landscape evolution. Simulations have been run using elevation and soil grading data of the engineered landform (spoil heap) at the Ranger Uranium Mine, Northern Territory, Australia. The results obtained for the coupled landform-soil evolution simulations predict the erosion of high slope areas, development of rudimentary channel networks in the landform and deposition of sediments in lowland areas, and qualitatively consistent with landform evolution models on their own. Examination of the soil profile characteristics revealed that hill crests are weathering dominated and tend to develop a thick soil layer. The steeper hillslopes at the edge of the landform are erosion dominated with shallow soils while the foot slopes are deposition dominated with thick soil layers. The simulation results of our coupled landform and soil evolution model provide qualitatively correct and timely characterization of the soil evolution on a dynamic landscape. Finally we will compare the characteristics of erosion and deposition predicted by the coupled landform-soil SSSPAM

  19. Ares I Scale Model Acoustic Test Above Deck Water Sound Suppression Results

    Science.gov (United States)

    Counter, Douglas D.; Houston, Janice D.

    2011-01-01

    The Ares I Scale Model Acoustic Test (ASMAT) program test matrix was designed to determine the acoustic reduction for the Liftoff acoustics (LOA) environment with an above deck water sound suppression system. The scale model test can be used to quantify the effectiveness of the water suppression system as well as optimize the systems necessary for the LOA noise reduction. Several water flow rates were tested to determine which rate provides the greatest acoustic reductions. Preliminary results are presented.

  20. Modelling global freshwater resources using WaterGAP 2.2 - model overview, selected results and applications

    Science.gov (United States)

    Müller Schmied, Hannes; Adam, Linda; Döll, Petra; Eisner, Stephanie; Flörke, Martina; Güntner, Andreas; Kynast, Ellen; Portmann, Felix T.; Riedel, Claudia; Schneider, Christoph; Song, Qi; Wattenbach, Martin; Zhang, Jing

    2014-05-01

    The estimation of global freshwater flows and storages and their dynamics is essential for the assessment of historical and future water availability both for mankind and ecosystems. WaterGAP 2 is a state-of-the-art water model covering the entire global land area (except Antarctica) on a 0.5° by 0.5° grid. WaterGAP consists of a set of water use models and a hydrological model. Five global water use models representing the sectors irrigation, domestic water demand, manufacturing industries, livestock farming and cooling of thermal power plants inform the sub-model GWSWUSE which calculates net water abstractions distinguishing surface water and groundwater sources. Water flows and storages are simulated by the WaterGAP Global Hydrology Model (WGHM). WGHM is calibrated against measured discharge for basins covering around 50 % of global land area. Since the original development of WaterGAP in the late 1990s, new input data and refined process algorithms have led to a significant improvement of the results. We present the current version WaterGAP 2.2 including selected results (e.g. discharge seasonality, water storage) and the global water balance for the time period 1971-2000. In addition, some examples of the application of WaterGAP output, e.g. within the GRACE community and for global environmental assessments are shown, reflecting the importance of global hydrology modeling in our globalized world.

  1. The use of the k - {epsilon} turbulence model within the Rossby Centre regional ocean climate model: parameterization development and results

    Energy Technology Data Exchange (ETDEWEB)

    Markus Meier, H.E. [Swedish Meteorological and Hydrological Inst., Norrkoeping (Sweden). Rossby Centre

    2000-09-01

    As mixing plays a dominant role for the physics of an estuary like the Baltic Sea (seasonal heat storage, mixing in channels, deep water mixing), different mixing parameterizations for use in 3D Baltic Sea models are discussed and compared. For this purpose two different OGCMs of the Baltic Sea are utilized. Within the Swedish regional climate modeling program, SWECLIM, a 3D coupled ice-ocean model for the Baltic Sea has been coupled with an improved version of the two-equation k - {epsilon} turbulence model with corrected dissipation term, flux boundary conditions to include the effect of a turbulence enhanced layer due to breaking surface gravity waves and a parameterization for breaking internal waves. Results of multi-year simulations are compared with observations. The seasonal thermocline is simulated satisfactory and erosion of the halocline is avoided. Unsolved problems are discussed. To replace the controversial equation for dissipation the performance of a hierarchy of k-models has been tested and compared with the k - {epsilon} model. In addition, it is shown that the results of the mixing parameterization depend very much on the choice of the ocean model. Finally, the impact of two mixing parameterizations on Baltic Sea climate is investigated. In this case the sensitivity of mean SST, vertical temperature and salinity profiles, ice season and seasonal cycle of heat fluxes is quite large.

  2. A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results.

    Science.gov (United States)

    Ampatzoglou, Pantelis; Dassios, George; Hadjinicolaou, Maria; Kourea, Helen P; Vrahatis, Michael N

    2015-01-01

    In the present manuscript we propose a lattice free multiscale model for avascular tumor growth that takes into account the biochemical environment, mitosis, necrosis, cellular signaling and cellular mechanics. This model extends analogous approaches by assuming a function that incorporates the biochemical energy level of the tumor cells and a mechanism that simulates the behavior of cancer stem cells. Numerical simulations of the model are used to investigate the morphology of the tumor at the avascular phase. The obtained results show similar characteristics with those observed in clinical data in the case of the Ductal Carcinoma In Situ (DCIS) of the breast.

  3. [DESCRIPTION AND PRESENTATION OF THE RESULTS OF ELECTROENCEPHALOGRAM PROCESSING USING AN INFORMATION MODEL].

    Science.gov (United States)

    Myznikov, I L; Nabokov, N L; Rogovanov, D Yu; Khankevich, Yu R

    2016-01-01

    The paper proposes to apply the informational modeling of correlation matrix developed by I.L. Myznikov in early 1990s in neurophysiological investigations, such as electroencephalogram recording and analysis, coherence description of signals from electrodes on the head surface. The authors demonstrate information models built using the data from studies of inert gas inhalation by healthy human subjects. In the opinion of the authors, information models provide an opportunity to describe physiological processes with a high level of generalization. The procedure of presenting the EEG results holds great promise for the broad application.

  4. An Enhanced Box-Wing Solar Radiation pressure model for BDS and initial results

    Science.gov (United States)

    Zhao, Qunhe; Wang, Xiaoya; Hu, Xiaogong; Guo, Rui; Shang, Lin; Tang, Chengpan; Shao, Fan

    2016-04-01

    Solar radiation pressure forces are the largest non-gravitational perturbations acting on GNSS satellites, which is difficult to be accurately modeled due to the complicated and changing satellite attitude and unknown surface material characteristics. By the end of 2015, there are more than 50 stations of the Multi-GNSS Experiment(MGEX) set-up by the IGS. The simple box-plate model relies on coarse assumptions about the dimensions and optical properties of the satellite due to lack of more detailed information. So, a physical model based on BOX-WING model is developed, which is more sophisticated and more detailed physical structure has been taken into account, then calculating pressure forces according to the geometric relations between light rays and surfaces. All the MGEX stations and IGS core stations had been processed for precise orbit determination tests with GPS and BDS observations. Calculation range covers all the two kinds of Eclipsing and non-eclipsing periods in 2015, and we adopted the un-differential observation mode and more accurate values of satellite phase centers. At first, we tried nine parameters model, and then eliminated the parameters with strong correlation between them, came into being five parameters of the model. Five parameters were estimated, such as solar scale, y-bias, three material coefficients of solar panel, x-axis and z-axis panels. Initial results showed that, in the period of yaw-steering mode, use of Enhanced ADBOXW model results in small improvement for IGSO and MEO satellites, and the Root-Mean-Square(RMS) error value of one-day arc orbit decreased by about 10%~30% except for C08 and C14. The new model mainly improved the along track acceleration, up to 30% while in the radial track was not obvious. The Satellite Laser Ranging(SLR) validation showed, however, that this model had higher prediction accuracy in the period of orbit-normal mode, compared to GFZ multi-GNSS orbit products, as well with relative post

  5. Comparison of multi-ħω shell-model results with MCAS

    Directory of Open Access Journals (Sweden)

    Svenne J. P.

    2014-03-01

    Full Text Available A multi-channel algebraic scattering (MCAS method has been used to obtain spectra of a number of light-mass nuclei, which are treated as a two-cluster system, here specifically a nucleon plus nucleus. To date, collective models have been used to specify the interactions between the nucleon and low-lying states of the nucleus that form the compound. For the case of the carbon isotopes, these studies have been complemented by sufficiently complex and complete shell-model calculations. Comparisons with the multi-ħω shell-model results provide new insights into the validity of those from MCAS.

  6. Spatial resolution effect on the simulated results of watershed scale models

    Science.gov (United States)

    Epelde, Ane; Antiguedad, Iñaki; Brito, David; Jauch, Eduardo; Neves, Ramiro; Sauvage, Sabine; Sánchez-Pérez, José Miguel

    2016-04-01

    Numerical models are useful tools for water resources planning, development and management. Currently, their use is being spread and more complex modeling systems are being employed for these purposes. The adding of complexity allows the simulation of water quality related processes. Nevertheless, this implies a considerable increase on the computational requirements, which usually is compensated on the models by a decrease on their spatial resolution. The spatial resolution of the models is known to affect the simulation of hydrological processes and therefore, also the nutrient exportation and cycling processes. However, the implication of the spatial resolution on the simulated results is rarely assessed. In this study, we examine the effect of the change in the grid size on the integrated and distributed results of the Alegria River watershed model (Basque Country, Northern Spain). Variables such as discharge, water table level, relative water content of soils, nitrogen exportation and denitrification are analyzed in order to quantify the uncertainty involved in the spatial discretization of the watershed scale models. This is an aspect that needs to be carefully considered when numerical models are employed in watershed management studies or quality programs.

  7. A mathematical model and simulation results of plasma enhanced chemical vapor deposition of silicon nitride films

    Science.gov (United States)

    Konakov, S. A.; Krzhizhanovskaya, V. V.

    2015-01-01

    We developed a mathematical model of Plasma Enhanced Chemical Vapor Deposition (PECVD) of silicon nitride thin films from SiH4-NH3-N2-Ar mixture, an important application in modern materials science. Our multiphysics model describes gas dynamics, chemical physics, plasma physics and electrodynamics. The PECVD technology is inherently multiscale, from macroscale processes in the chemical reactor to atomic-scale surface chemistry. Our macroscale model is based on Navier-Stokes equations for a transient laminar flow of a compressible chemically reacting gas mixture, together with the mass transfer and energy balance equations, Poisson equation for electric potential, electrons and ions balance equations. The chemical kinetics model includes 24 species and 58 reactions: 37 in the gas phase and 21 on the surface. A deposition model consists of three stages: adsorption to the surface, diffusion along the surface and embedding of products into the substrate. A new model has been validated on experimental results obtained with the "Plasmalab System 100" reactor. We present the mathematical model and simulation results investigating the influence of flow rate and source gas proportion on silicon nitride film growth rate and chemical composition.

  8. Method for evaluating prediction models that apply the results of randomized trials to individual patients

    Directory of Open Access Journals (Sweden)

    Kattan Michael W

    2007-06-01

    Full Text Available Abstract Introduction The clinical significance of a treatment effect demonstrated in a randomized trial is typically assessed by reference to differences in event rates at the group level. An alternative is to make individualized predictions for each patient based on a prediction model. This approach is growing in popularity, particularly for cancer. Despite its intuitive advantages, it remains plausible that some prediction models may do more harm than good. Here we present a novel method for determining whether predictions from a model should be used to apply the results of a randomized trial to individual patients, as opposed to using group level results. Methods We propose applying the prediction model to a data set from a randomized trial and examining the results of patients for whom the treatment arm recommended by a prediction model is congruent with allocation. These results are compared with the strategy of treating all patients through use of a net benefit function that incorporates both the number of patients treated and the outcome. We examined models developed using data sets regarding adjuvant chemotherapy for colorectal cancer and Dutasteride for benign prostatic hypertrophy. Results For adjuvant chemotherapy, we found that patients who would opt for chemotherapy even for small risk reductions, and, conversely, those who would require a very large risk reduction, would on average be harmed by using a prediction model; those with intermediate preferences would on average benefit by allowing such information to help their decision making. Use of prediction could, at worst, lead to the equivalent of an additional death or recurrence per 143 patients; at best it could lead to the equivalent of a reduction in the number of treatments of 25% without an increase in event rates. In the Dutasteride case, where the average benefit of treatment is more modest, there is a small benefit of prediction modelling, equivalent to a reduction of

  9. Exploring the uncertainties of early detection results: model-based interpretation of mayo lung project

    Directory of Open Access Journals (Sweden)

    Berman Barbara

    2011-03-01

    Full Text Available Abstract Background The Mayo Lung Project (MLP, a randomized controlled clinical trial of lung cancer screening conducted between 1971 and 1986 among male smokers aged 45 or above, demonstrated an increase in lung cancer survival since the time of diagnosis, but no reduction in lung cancer mortality. Whether this result necessarily indicates a lack of mortality benefit for screening remains controversial. A number of hypotheses have been proposed to explain the observed outcome, including over-diagnosis, screening sensitivity, and population heterogeneity (initial difference in lung cancer risks between the two trial arms. This study is intended to provide model-based testing for some of these important arguments. Method Using a micro-simulation model, the MISCAN-lung model, we explore the possible influence of screening sensitivity, systematic error, over-diagnosis and population heterogeneity. Results Calibrating screening sensitivity, systematic error, or over-diagnosis does not noticeably improve the fit of the model, whereas calibrating population heterogeneity helps the model predict lung cancer incidence better. Conclusions Our conclusion is that the hypothesized imperfection in screening sensitivity, systematic error, and over-diagnosis do not in themselves explain the observed trial results. Model fit improvement achieved by accounting for population heterogeneity suggests a higher risk of cancer incidence in the intervention group as compared with the control group.

  10. Proposed Schematics and Modeling Results for a Lunar Portable Life Support System

    Science.gov (United States)

    Conger, Bruce; Chullen, Cinda

    2009-01-01

    The Constellation Space Suit Element (CSSE) is an integrated assembly made up of primarily a Pressure Garment System (PGS) and a Portable Life Support System (PLSS). The PLSS is further composed of an oxygen (O2) subsystem, a ventilation subsystem, and a thermal subsystem. This paper baselines a detailed schematic of the CSSE PLSS to provide a basis for current and future CSSE PLSS development efforts. Both context diagrams and detailed schematics describe the hardware components and overall functions for all three of the PLSS subsystems. Additionally, PLSS functions are presented for multiple operational scenarios as follows: 1) Nominal Extravehicular Activity (EVA) Mode; 2) Umbilical Modes; a) No Recharge, b) With Recharge; 3) Decompression Sickness (DCS) Treatment Mode; 4) Buddy Mode; 5) Secondary O2 Modes; a) Helmet Purge; b) Suit Purge; c) Operational; and 5) PLSS Removed Umbilical Mode. A performance modeling effort is being performed to provide a preliminary confirmation of this layout and the current state of the thermal hydraulic modeling efforts being conducted for the PLSS is presented. The goal of these efforts is to provide realistic simulations of the PLSS under various modes of operation. Modeling approaches and assumptions are discussed as well as component model descriptions. Results from the models are included that show PLSS operations at steady-state and transient conditions. Finally, conclusions and recommendations are offered that summarize results, identify PLSS design weaknesses uncovered during review of the analysis results, and propose areas for improvement to increase model fidelity and accuracy.

  11. Modelled and Observed Diurnal SST Signals: "SSTDV:R.EX.-IM.A.M." Project Preliminary Results

    DEFF Research Database (Denmark)

    Karagali, Ioanna; Høyer, Jacob; LeBorgne, Pierre

    2013-01-01

    This study presents some of the preliminary results from the ESA Support To Science Element (STSE) funded project on the Diurnal Variability of the Sea Surface Temperature, regarding its Regional Extend and Implications in Atmospheric Modelling (SSTDV:R.EX.–IM.A.M.). During this phase...... of the project, the focus is on the regional extend of diurnal variability. Particularly, extensive sensitivity tests regarding the definition of SSTfound fields show that using only quality 5 SEVIRI data results in warmer foundation fields SSTfound while there is an added ∼0.2 K variability when using multi...... Ocean Turbulence Model (GOTM) is applied. Preliminary results show that the initial temperature profiles may give a warmer start-up in the model while the light extinction scheme is a controlling factor for the amplitude and vertical extend of the daily signal....

  12. Robustness of life cycle assessment results : influence of data variation and modelling choices on results for beverage packaging materials

    NARCIS (Netherlands)

    Harst-Wintraecken, van der E.J.M.

    2015-01-01

    Life cycle assessment (LCA) is a well-established method to evaluate the potential environmental impacts of product and service systems throughout their life cycles. However, it can happen that LCAs for the same product have different and even conflicting outcomes. LCA results need to be robust and

  13. Action versus result-oriented schemes in a grassland agroecosystem: a dynamic modelling approach.

    Science.gov (United States)

    Sabatier, Rodolphe; Doyen, Luc; Tichit, Muriel

    2012-01-01

    Effects of agri-environment schemes (AES) on biodiversity remain controversial. While most AES are action-oriented, result-oriented and habitat-oriented schemes have recently been proposed as a solution to improve AES efficiency. The objective of this study was to compare action-oriented, habitat-oriented and result-oriented schemes in terms of ecological and productive performance as well as in terms of management flexibility. We developed a dynamic modelling approach based on the viable control framework to carry out a long term assessment of the three schemes in a grassland agroecosystem. The model explicitly links grazed grassland dynamics to bird population dynamics. It is applied to lapwing conservation in wet grasslands in France. We ran the model to assess the three AES scenarios. The model revealed the grazing strategies respecting ecological and productive constraints specific to each scheme. Grazing strategies were assessed by both their ecological and productive performance. The viable control approach made it possible to obtain the whole set of viable grazing strategies and therefore to quantify the management flexibility of the grassland agroecosystem. Our results showed that habitat and result-oriented scenarios led to much higher ecological performance than the action-oriented one. Differences in both ecological and productive performance between the habitat and result-oriented scenarios were limited. Flexibility of the grassland agroecosystem in the result-oriented scenario was much higher than in that of habitat-oriented scenario. Our model confirms the higher flexibility as well as the better ecological and productive performance of result-oriented schemes. A larger use of result-oriented schemes in conservation may also allow farmers to adapt their management to local conditions and to climatic variations.

  14. Action versus result-oriented schemes in a grassland agroecosystem: a dynamic modelling approach.

    Directory of Open Access Journals (Sweden)

    Rodolphe Sabatier

    Full Text Available Effects of agri-environment schemes (AES on biodiversity remain controversial. While most AES are action-oriented, result-oriented and habitat-oriented schemes have recently been proposed as a solution to improve AES efficiency. The objective of this study was to compare action-oriented, habitat-oriented and result-oriented schemes in terms of ecological and productive performance as well as in terms of management flexibility. We developed a dynamic modelling approach based on the viable control framework to carry out a long term assessment of the three schemes in a grassland agroecosystem. The model explicitly links grazed grassland dynamics to bird population dynamics. It is applied to lapwing conservation in wet grasslands in France. We ran the model to assess the three AES scenarios. The model revealed the grazing strategies respecting ecological and productive constraints specific to each scheme. Grazing strategies were assessed by both their ecological and productive performance. The viable control approach made it possible to obtain the whole set of viable grazing strategies and therefore to quantify the management flexibility of the grassland agroecosystem. Our results showed that habitat and result-oriented scenarios led to much higher ecological performance than the action-oriented one. Differences in both ecological and productive performance between the habitat and result-oriented scenarios were limited. Flexibility of the grassland agroecosystem in the result-oriented scenario was much higher than in that of habitat-oriented scenario. Our model confirms the higher flexibility as well as the better ecological and productive performance of result-oriented schemes. A larger use of result-oriented schemes in conservation may also allow farmers to adapt their management to local conditions and to climatic variations.

  15. The comparison of the results of numerical modeling and physical model experiment on laser polarization sensing of droplet clouds

    Science.gov (United States)

    Doroshkevich, A. A.; Bryukhanova, V. V.; Samokhvalov, I. V.; Stykon, A. P.

    2014-11-01

    The task of laser sensing of droplet clouds by coaxial lidar is considered. Lidar return due to single scattering is formed in the volume bounded by the radiation pattern of the transmitter, while the double-scattering is determined by a receiving system field of view. The volume of the scattering medium exceeding a receiving system field of view forms the signal higher scattering orders ( < 2). The results of the numerical modeling of the distribution (in the recording plane) polarization characteristics of lidar signal from droplet clouds in the double scattering approximation in comparison with the results of the physical model experiment simulating sounding of a droplet cloud are discussed in this paper.

  16. Lattice Hamiltonian approach to the Schwinger model. Further results from the strong coupling expansion

    Energy Technology Data Exchange (ETDEWEB)

    Szyniszewski, Marcin [Lancaster Univ. (United Kingdom). Dept. of Physics; Manchester Univ. (United Kingdom). NoWNano DTC; Cichy, Krzysztof [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Poznan Univ. (Poland). Faculty of Physics; Kujawa-Cichy, Agnieszka [Frankfurt Univ., Frankfurt am Main (Germany). Inst. fuer Theortische Physik

    2014-10-15

    We employ exact diagonalization with strong coupling expansion to the massless and massive Schwinger model. New results are presented for the ground state energy and scalar mass gap in the massless model, which improve the precision to nearly 10{sup -9}%. We also investigate the chiral condensate and compare our calculations to previous results available in the literature. Oscillations of the chiral condensate which are present while increasing the expansion order are also studied and are shown to be directly linked to the presence of flux loops in the system.

  17. Development of in vitro models for investigating spatially fractionated irradiation: physics and biological results

    Science.gov (United States)

    Blockhuys, S; Vanhoecke, B; Paelinck, L; Bracke, M; DeWagter, C

    2009-03-01

    We present different in vitro experimental models which allow us to evaluate the effect of spatially fractionated dose distributions on metabolic activity. We irradiated a monolayer of MCF-7/6 human breast cancer cells with a steep and a smooth 6 MV x-ray dose gradient. In the steep gradient model, we irradiated the cells with three separate small fields. We also developed two smooth gradient models. In the first model, the cells are cultured in a T25 flask and irradiated with a smooth dose gradient over the length of the flask, while in the second one, the cells are cultured in a 96-well plate and also irradiated over the length of the plate. In an attempt to correlate the spatially fractionated dose distributions with metabolic activity, the effect of irradiation was evaluated by means of the MTT assay. This assay is used to determine the metabolic activity by measuring the amount of formazan formed after the conversion of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) by cellular dehydrogenases. The results obtained with our different models suggest a dose-specific effect on metabolic activity, characterized by an increased formazan optical density occurring in the dose range 1.0-4.0 Gy in the steep dose gradient model and in the dose ranges 4.2-6.5 Gy and 2.3-5.1 Gy in the two smooth dose gradient models. The corresponding times for maximal formazan accumulation were 5-7 days in the steep dose gradient model and day 9-13 and day 9-11 in the smooth dose gradient models. Altogether, our results suggest that the MTT assay may be used as a biological dose-response meter to monitor the radiotherapeutic effectiveness.

  18. Development of in vitro models for investigating spatially fractionated irradiation: physics and biological results

    Energy Technology Data Exchange (ETDEWEB)

    Blockhuys, S; Vanhoecke, B; Bracke, M [Laboratory Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, B-9000 Gent (Belgium); Paelinck, L; De Wagter, C [Department of Radiotherapy, Ghent University Hospital, De Pintelaan 185, B-9000 Gent (Belgium)], E-mail: Stephanie.Blockhuys@ugent.be

    2009-03-21

    We present different in vitro experimental models which allow us to evaluate the effect of spatially fractionated dose distributions on metabolic activity. We irradiated a monolayer of MCF-7/6 human breast cancer cells with a steep and a smooth 6 MV x-ray dose gradient. In the steep gradient model, we irradiated the cells with three separate small fields. We also developed two smooth gradient models. In the first model, the cells are cultured in a T25 flask and irradiated with a smooth dose gradient over the length of the flask, while in the second one, the cells are cultured in a 96-well plate and also irradiated over the length of the plate. In an attempt to correlate the spatially fractionated dose distributions with metabolic activity, the effect of irradiation was evaluated by means of the MTT assay. This assay is used to determine the metabolic activity by measuring the amount of formazan formed after the conversion of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) by cellular dehydrogenases. The results obtained with our different models suggest a dose-specific effect on metabolic activity, characterized by an increased formazan optical density occurring in the dose range 1.0-4.0 Gy in the steep dose gradient model and in the dose ranges 4.2-6.5 Gy and 2.3-5.1 Gy in the two smooth dose gradient models. The corresponding times for maximal formazan accumulation were 5-7 days in the steep dose gradient model and day 9-13 and day 9-11 in the smooth dose gradient models. Altogether, our results suggest that the MTT assay may be used as a biological dose-response meter to monitor the radiotherapeutic effectiveness.

  19. Application of a computationally efficient method to approximate gap model results with a probabilistic approach

    Science.gov (United States)

    Scherstjanoi, M.; Kaplan, J. O.; Lischke, H.

    2014-07-01

    To be able to simulate climate change effects on forest dynamics over the whole of Switzerland, we adapted the second-generation DGVM (dynamic global vegetation model) LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) to the Alpine environment. We modified model functions, tuned model parameters, and implemented new tree species to represent the potential natural vegetation of Alpine landscapes. Furthermore, we increased the computational efficiency of the model to enable area-covering simulations in a fine resolution (1 km) sufficient for the complex topography of the Alps, which resulted in more than 32 000 simulation grid cells. To this aim, we applied the recently developed method GAPPARD (approximating GAP model results with a Probabilistic Approach to account for stand Replacing Disturbances) (Scherstjanoi et al., 2013) to LPJ-GUESS. GAPPARD derives mean output values from a combination of simulation runs without disturbances and a patch age distribution defined by the disturbance frequency. With this computationally efficient method, which increased the model's speed by approximately the factor 8, we were able to faster detect the shortcomings of LPJ-GUESS functions and parameters. We used the adapted LPJ-GUESS together with GAPPARD to assess the influence of one climate change scenario on dynamics of tree species composition and biomass throughout the 21st century in Switzerland. To allow for comparison with the original model, we additionally simulated forest dynamics along a north-south transect through Switzerland. The results from this transect confirmed the high value of the GAPPARD method despite some limitations towards extreme climatic events. It allowed for the first time to obtain area-wide, detailed high-resolution LPJ-GUESS simulation results for a large part of the Alpine region.

  20. Preliminary results of Physiological plant growth modelling for human life support in space

    Science.gov (United States)

    Sasidharan L, Swathy; Dussap, Claude-Gilles; Hezard, Pauline

    2012-07-01

    physiological plant model, in the case of lettuce (since the leaf metabolic model predominates), the developed model was verified with the carbon consumption of plant, as input. The model predicts the biomass production (as output) with respect to the quantum of light absorbed by the plant. The obtained result was found satisfying for the first initiation in the physiological plant modelling.

  1. Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease

    Directory of Open Access Journals (Sweden)

    Timo Friedrich

    2012-03-01

    Analysis of zebrafish mutants that demonstrate abnormal locomotive behavior can elucidate the molecular requirements for neural network function and provide new models of human disease. Here, we show that zebrafish quetschkommode (que mutant larvae exhibit a progressive locomotor defect that culminates in unusual nose-to-tail compressions and an inability to swim. Correspondingly, extracellular peripheral nerve recordings show that que mutants demonstrate abnormal locomotor output to the axial muscles used for swimming. Using positional cloning and candidate gene analysis, we reveal that a point mutation disrupts the gene encoding dihydrolipoamide branched-chain transacylase E2 (Dbt, a component of a mitochondrial enzyme complex, to generate the que phenotype. In humans, mutation of the DBT gene causes maple syrup urine disease (MSUD, a disorder of branched-chain amino acid metabolism that can result in mental retardation, severe dystonia, profound neurological damage and death. que mutants harbor abnormal amino acid levels, similar to MSUD patients and consistent with an error in branched-chain amino acid metabolism. que mutants also contain markedly reduced levels of the neurotransmitter glutamate within the brain and spinal cord, which probably contributes to their abnormal spinal cord locomotor output and aberrant motility behavior, a trait that probably represents severe dystonia in larval zebrafish. Taken together, these data illustrate how defects in branched-chain amino acid metabolism can disrupt nervous system development and/or function, and establish zebrafish que mutants as a model to better understand MSUD.

  2. RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis.

    Science.gov (United States)

    Noto, Michael J; Becker, Kyle W; Boyd, Kelli L; Schmidt, Ann Marie; Skaar, Eric P

    2017-03-01

    The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor capable of recognizing multiple pathogen-associated and danger-associated molecular patterns that contributes to the initiation and potentiation of inflammation in many disease processes. During infection, RAGE functions to either exacerbate disease severity or enhance pathogen clearance depending on the pathogen studied. Acinetobacter baumannii is an opportunistic human pathogen capable of causing severe infections, including pneumonia and sepsis, in impaired hosts. The role of RAGE signaling in response to opportunistic bacterial infections is largely unknown. In murine models of A. baumannii pneumonia, RAGE signaling alters neither inflammation nor bacterial clearance. In contrast, RAGE(-/-) mice systemically infected with A. baumannii exhibit increased survival and reduced bacterial burdens in the liver and spleen. The increased survival of RAGE(-/-) mice is associated with increased circulating levels of the anti-inflammatory cytokine interleukin-10 (IL-10). Neutralization of IL-10 in RAGE(-/-) mice results in decreased survival during systemic A. baumannii infection that mirrors that of wild-type (WT) mice, and exogenous IL-10 administration to WT mice enhances survival in this model. These findings demonstrate the role for RAGE-dependent IL-10 suppression as a key modulator of mortality from Gram-negative sepsis. Copyright © 2017 American Society for Microbiology.

  3. Accessible integration of agriculture, groundwater, and economic models using the Open Modeling Interface (OpenMI: methodology and initial results

    Directory of Open Access Journals (Sweden)

    T. Bulatewicz

    2010-03-01

    Full Text Available Policy for water resources impacts not only hydrological processes, but the closely intertwined economic and social processes dependent on them. Understanding these process interactions across domains is an important step in establishing effective and sustainable policy. Multidisciplinary integrated models can provide insight to inform this understanding, though the extent of software development necessary is often prohibitive, particularly for small teams of researchers. Thus there is a need for practical methods for building interdisciplinary integrated models that do not incur a substantial development effort. In this work we adopt the strategy of linking individual domain models together to build a multidisciplinary integrated model. The software development effort is minimized through the reuse of existing models and existing model-linking tools without requiring any changes to the model source codes, and linking these components through the use of the Open Modeling Interface (OpenMI. This was found to be an effective approach to building an agricultural-groundwater-economic integrated model for studying the effects of water policy in irrigated agricultural systems. The construction of the integrated model provided a means to evaluate the impacts of two alternative water-use policies aimed at reducing irrigated water use to sustainable levels in the semi-arid grasslands overlying the Ogallala Aquifer of the Central US. The results show how both the economic impact in terms of yield and revenue and the environmental impact in terms of groundwater level vary spatially throughout the study region for each policy. Accessible integration strategies are necessary if the practice of interdisciplinary integrated simulation is to become widely adopted.

  4. Modeling of Na airglow emission and first results on the nocturnal variation at midlatitude

    Science.gov (United States)

    Bag, T.; Sunil Krishna, M. V.; Singh, Vir

    2015-12-01

    A model for sodium airglow emission is developed by incorporating all the known reaction mechanisms. The neutral, ionic, and photochemical mechanisms are successfully implemented into this model. The values of reaction rate coefficients are based upon the theoretical calculations as well as from experimental observations. The densities of major species are calculated using the continuity equations, whereas for the minor, intermediating, and short-lived species steady state approximation method is used. The modeled results are validated with the rocket, lidar, and photometer observations for a branching ratio of 0.04 for the production of Na(2P) in the reaction NaO + O → Na(2P, 2S). The inputs have been obtained from other physics-based models and ground- and satellite-based observations to give the combined volume emission rate (VER) of Na airglow between 80 and 110 km altitude. In the present study, the model is used to understand the nocturnal variation of Na VER during the solstice conditions. The model results suggest a variation of peak emission layer between 85 and 90 km during summer solstice condition, indicating a lower value of peak emission rate during summer solstice. The emission rates bear a strong correlation with the O3 density during summer solstice, whereas the magnitude of VER follows the Na density during winter solstice. The altitude of peak VER shows an upward shift of 5 km during winter solstice.

  5. Comparison of TS and ANN Models with the Results of Emission Scenarios in Rainfall Prediction

    Directory of Open Access Journals (Sweden)

    S. Babaei Hessar

    2016-02-01

    Full Text Available Introduction: Precipitation is one of the most important and sensitive parameters of the tropical climate that influence the catchments hydrological regime. The prediction of rainfall is vital for strategic planning and water resources management. Despite its importance, statistical rainfall forecasting, especially for long-term, has been proven to be a great challenge due to the dynamic nature of climate phenomena and random fluctuations involved in the process. Various methods, such as time series and artificial neural network models, have been proposed to predict the level of rainfall. But there is not enough attention to global warming and climate change issues. The main aim of this study is to investigate the conformity of artificial neural network and time series models with climate scenarios. Materials and Methods: For this study, 50 years of daily rainfall data (1961 to 2010 of the synoptic station of Urmia, Tabriz and Khoy was investigated. Data was obtained from Meteorological Organization of Iran. In the present study, the results of two Artificial Neural Network (ANN and Time Seri (TS methods were compared with the result of the Emission Scenarios (A2 & B1. HadCM3 model in LARS-WG software was used to generate rainfall for the next 18 years (2011-2029. The results of models were compared with climate scenarios over the next 18 years in the three synoptic stations located in the basin of the Lake Urmia. At the first stage, the best model of time series method was selected. The precipitation was estimated for the next 18 years using these models. For the same period, precipitation was forecast using artificial neural networks. Finally, the results of two models were compared with data generated under two scenarios (B1 and A2 in LARS-WG. Results and Discussion: Different order of AR, MA and ARMA was examined to select the best model of TS The results show that AR(1 was suitable for Tabriz and Khoy stations .In the Urmia station MA(1 was

  6.  Functional Results-Oriented Healthcare Leadership: A Novel Leadership Model

    Directory of Open Access Journals (Sweden)

    Salem Said Al-Touby

    2012-03-01

    Full Text Available  This article modifies the traditional functional leadership model to accommodate contemporary needs in healthcare leadership based on two findings. First, the article argues that it is important that the ideal healthcare leadership emphasizes the outcomes of the patient care more than processes and structures used to deliver such care; and secondly, that the leadership must strive to attain effectiveness of their care provision and not merely targeting the attractive option of efficient operations. Based on these premises, the paper reviews the traditional Functional Leadership Model and the three elements that define the type of leadership an organization has namely, the tasks, the individuals, and the team. The article argues that concentrating on any one of these elements is not ideal and proposes adding a new element to the model to construct a novel Functional Result-Oriented healthcare leadership model. The recommended Functional-Results Oriented leadership model embosses the results element on top of the other three elements so that every effort on healthcare leadership is directed towards attaining excellent patient outcomes.

  7. Investigating Design Research Landscapes through Exhibition

    DEFF Research Database (Denmark)

    Jönsson, Li; Hansen, Flemming Tvede; Mäkelä, Maarit;

    2013-01-01

    What characterizes a design research exhibition compared to a traditional design and art exhibition? How do you show the very materialities of the design experiments as a means for communicating knowledge of research and of practice? How do you present, review and utilize such an exhibition......? With those questions in mind, the intention and challenge for the Nordes 2013 Design Research Exhibition was to expand on current notions of staging research enquires in design research conference contexts. Artefacts, installations, performances, and other materialities that relate to the theme...... of the conference - Experiments in Design Research – were displayed as tools to express and communicate different design research enquires. Through this paper we will describe the Nordes exhibition as a specific case that renders questions visible in relation to how to utilize a design research exhibition...

  8. Conversion of IVA Human Computer Model to EVA Use and Evaluation and Comparison of the Result to Existing EVA Models

    Science.gov (United States)

    Hamilton, George S.; Williams, Jermaine C.

    1998-01-01

    This paper describes the methods, rationale, and comparative results of the conversion of an intravehicular (IVA) 3D human computer model (HCM) to extravehicular (EVA) use and compares the converted model to an existing model on another computer platform. The task of accurately modeling a spacesuited human figure in software is daunting: the suit restricts the human's joint range of motion (ROM) and does not have joints collocated with human joints. The modeling of the variety of materials needed to construct a space suit (e. g. metal bearings, rigid fiberglass torso, flexible cloth limbs and rubber coated gloves) attached to a human figure is currently out of reach of desktop computer hardware and software. Therefore a simplified approach was taken. The HCM's body parts were enlarged and the joint ROM was restricted to match the existing spacesuit model. This basic approach could be used to model other restrictive environments in industry such as chemical or fire protective clothing. In summary, the approach provides a moderate fidelity, usable tool which will run on current notebook computers.

  9. Latest results from the EU project AVATAR: Aerodynamic modelling of 10 MW wind turbines

    DEFF Research Database (Denmark)

    Schepers O. Ceyhan, J. G.; Boorsma, K.; Gonzalez, A.;

    2016-01-01

    This paper presents the most recent results from the EU project AVATAR in which aerodynamic models are improved and validated for wind turbines on a scale of 10 MW and more. Measurements on a DU 00-W-212 airfoil are presented which have been taken in the pressurized DNW-HDG wind tunnel up to a Re...... results from 3D rotor models where a comparison is made between results from vortex wake methods and BEM methods at yawed conditions....... showed an unexpected large scatter which eventually was reduced by paying even more attention to grid independency and domain size in relation to grid topology. Moreover calculations are presented on flow devices (leading and trailing edge flaps and vortex generators). Finally results are shown between...

  10. A Comparison of Results From NASA's Meteoroid Engineering Model to the LDEF Cratering Record

    Science.gov (United States)

    Ehlert, S.; Moorhead, A.; Cooke, W. J.

    2017-01-01

    NASA's Long Duration Exposure Facility (LDEF) has provided an extensive record of the meteoroid environment in Low Earth Orbit. LDEF's combination of fixed orientation, large collecting area, and long lifetime imposes constraints on the absolute flux of potentially hazardous meteoroids. The relative impact rate on each of LDEF's fourteen surfaces arises from the underlying velocity distribution and directionality of the meteoroid environment. For the first time, we model the meteoroid environment encountered by LDEF over its operational lifetime using NASA's Meteoroid Engineering Model Release 2 (MEMR2) and compare the model results with the observed craters of potentially hazardous meteoroids (i.e. crater diameters larger than approximately 0.6 mm). We discuss the extent to which the observations and model agree and how the impact rates across all of the LDEF surfaces may suggest improvements to the underlying assumptions that go into future versions of MEM.

  11. Evidence for Symplectic Symmetry in Ab Initio No-Core Shell Model Results for Light Nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Dytrych, Tomas; Sviratcheva, Kristina D.; Bahri, Chairul; Draayer, Jerry P.; /Louisiana State U.; Vary, James P.; /Iowa State U. /LLNL, Livermore /SLAC

    2007-04-24

    Clear evidence for symplectic symmetry in low-lying states of {sup 12}C and {sup 16}O is reported. Eigenstates of {sup 12}C and {sup 16}O, determined within the framework of the no-core shell model using the JISP16 NN realistic interaction, typically project at the 85-90% level onto a few of the most deformed symplectic basis states that span only a small fraction of the full model space. The results are nearly independent of whether the bare or renormalized effective interactions are used in the analysis. The outcome confirms Elliott's SU(3) model which underpins the symplectic scheme, and above all, points to the relevance of a symplectic no-core shell model that can reproduce experimental B(E2) values without effective charges as well as deformed spatial modes associated with clustering phenomena in nuclei.

  12. Model unspecific search in CMS. Results at 8 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Andreas; Duchardt, Deborah; Hebbeker, Thomas; Knutzen, Simon; Lieb, Jonas; Meyer, Arnd; Pook, Tobias; Roemer, Jonas [III. Physikalisches Institut A, RWTH Aachen University (Germany)

    2016-07-01

    In the year 2012, CMS collected a total data set of approximately 20 fb{sup -1} in proton-proton collisions at √(s)=8 TeV. Dedicated searches for physics beyond the standard model are commonly designed with the signatures of a given theoretical model in mind. While this approach allows for an optimised sensitivity to the sought-after signal, it may cause unexpected phenomena to be overlooked. In a complementary approach, the Model Unspecific Search in CMS (MUSiC) analyses CMS data in a general way. Depending on the reconstructed final state objects (e.g. electrons), collision events are sorted into classes. In each of the classes, the distributions of selected kinematic variables are compared to standard model simulation. An automated statistical analysis is performed to quantify the agreement between data and prediction. In this talk, the analysis concept is introduced and selected results of the analysis of the 2012 CMS data set are presented.

  13. Comparison of measurements and model results for airborne sulphur and nitrogen components with kriging

    Energy Technology Data Exchange (ETDEWEB)

    Schaug, J.; Iversen, T.; Pedersen, U. (Norwegian Institute for Air Research, Lillestroem (Norway). Chemical Coordinating Centre of EMEP)

    1993-04-01

    Comparisons have been made between calculations from the Lagrangian model for acid deposition at Meteorological Synthesizing Centre-West (MSC-W) of EMEP and measurements at EMEP sites. Annual averages of aerosol sulphate, sulphate in precipitation and nitrate in precipitation were calculated and compared for selected sites. Site selection was based on data completeness and on results from EMEP interlaboratory exercises. The comparison for sulphates in precipitation and air led to a model underestimation in the north and model overestimation in a belt through the major source regions in central Europe. The comparisons also indicate irregularities at some sites which may be due to influence from local sources, or the data quality, although this is not substantiated. The model estimates of nitrate in precipitation compare well with the measurements, although some characteristic differences occur also for this component. 21 refs., 11 figs., 2 tabs.

  14. Model On DROID Response With Imperfect Trapping Tested On Experimental Results

    Science.gov (United States)

    Hijmering, R. A.; Kozorezov, A. G.; Verhoeve, P.; Martin, D. D. E.; Wigmore, J. K.; Venn, R.

    2009-12-01

    The DROID (Distributed Read-Out Imaging Detector) is being developed to overcome the limitation in sensitive area with the use of single STJ's (Superconducting Tunnel Junctions). The DROID configuration allows the reconstruction of the position of the photon absorption and therefore it can replace a number of single STJ's in a detector array. We present a 2D model which describes the response of DROIDs with partial trapping in the STJs. The model describes diffusion of quasiparticles (qps) and imperfect confinement via exchange of qps between the absorber and STJ. It incorporates possible diffusion mismatch between absorber and STJ, possible asymmetry between the STJs as well as between the base and top electrodes of the STJs, and photon absorption in the absorber or base or top film of the STJ. Dedicated experiments have been conducted to test the different aspects of the model. We find a good agreement between the model and experimental results.

  15. Preliminary mixed-layer model results for FIRE marine stratocumulus IFO conditions

    Science.gov (United States)

    Barlow, R.; Nicholls, S.

    1990-01-01

    Some preliminary results from the Turton and Nicholls mixed layer model using typical FIRE boundary conditions are presented. The model includes entrainment and drizzle parametrizations as well as interactive long and shortwave radiation schemes. A constraint on the integrated turbulent kinetic energy balance ensures that the model remains energetically consistent at all times. The preliminary runs were used to identify the potentially important terms in the heat and moisture budgets of the cloud layer, and to assess the anticipated diurnal variability. These are compared with typical observations from the C130. Sensitivity studies also revealed the remarkable stability of these cloud sheets: a number of negative feedback mechanisms appear to operate to maintain the cloud over an extended time period. These are also discussed. The degree to which such a modelling approach can be used to explain observed features, the specification of boundary conditions and problems of interpretation in non-horizontally uniform conditions is also raised.

  16. Global Monthly CO2 Flux Inversion Based on Results of Terrestrial Ecosystem Modeling

    Science.gov (United States)

    Deng, F.; Chen, J.; Peters, W.; Krol, M.

    2008-12-01

    Most of our understanding of the sources and sinks of atmospheric CO2 has come from inverse studies of atmospheric CO2 concentration measurements. However, the number of currently available observation stations and our ability to simulate the diurnal planetary boundary layer evolution over continental regions essentially limit the number of regions that can be reliably inverted globally, especially over continental areas. In order to overcome these restrictions, a nested inverse modeling system was developed based on the Bayesian principle for estimating carbon fluxes of 30 regions in North America and 20 regions for the rest of the globe. Inverse modeling was conducted in monthly steps using CO2 concentration measurements of 5 years (2000 - 2005) with the following two models: (a) An atmospheric transport model (TM5) is used to generate the transport matrix where the diurnal variation n of atmospheric CO2 concentration is considered to enhance the use of the afternoon-hour average CO2 concentration measurements over the continental sites. (b) A process-based terrestrial ecosystem model (BEPS) is used to produce hourly step carbon fluxes, which could minimize the limitation due to our inability to solve the inverse problem in a high resolution, as the background of our inversion. We will present our recent results achieved through a combination of the bottom-up modeling with BEPS and the top-down modeling based on TM5 driven by offline meteorological fields generated by the European Centre for Medium Range Weather Forecast (ECMFW).

  17. The interface free energy: Comparison of accurate Monte Carlo results for the 3D Ising model with effective interface models

    CERN Document Server

    Caselle, Michele; Panero, Marco

    2007-01-01

    We provide accurate Monte Carlo results for the free energy of interfaces with periodic boundary conditions in the 3D Ising model. We study a large range of inverse temperatures, allowing to control corrections to scaling. In addition to square interfaces, we study rectangular interfaces for a large range of aspect ratios u=L_1/L_2. Our numerical results are compared with predictions of effective interface models. This comparison verifies clearly the effective Nambu-Goto model up to two-loop order. Our data also allow us to obtain the estimates T_c sigma^-1/2=1.235(2), m_0++ sigma^-1/2=3.037(16) and R_+=f_+ sigma_0^2 =0.387(2), which are more precise than previous ones.

  18. Comparison of results of experimental research with numerical calculations of a model one-sided seal

    Directory of Open Access Journals (Sweden)

    Joachimiak Damian

    2015-06-01

    Full Text Available Paper presents the results of experimental and numerical research of a model segment of a labyrinth seal for a different wear level. The analysis covers the extent of leakage and distribution of static pressure in the seal chambers and the planes upstream and downstream of the segment. The measurement data have been compared with the results of numerical calculations obtained using commercial software. Based on the flow conditions occurring in the area subjected to calculations, the size of the mesh defined by parameter y+ has been analyzed and the selection of the turbulence model has been described. The numerical calculations were based on the measurable thermodynamic parameters in the seal segments of steam turbines. The work contains a comparison of the mass flow and distribution of static pressure in the seal chambers obtained during the measurement and calculated numerically in a model segment of the seal of different level of wear.

  19. Comparative Results on 3D Navigation of Quadrotor using two Nonlinear Model based Controllers

    Science.gov (United States)

    Bouzid, Y.; Siguerdidjane, H.; Bestaoui, Y.

    2017-01-01

    Recently the quadrotors are being increasingly employed in both military and civilian areas where a broad range of nonlinear flight control techniques are successfully implemented. With this advancement, it has become necessary to investigate the efficiency of these flight controllers by studying theirs features and compare their performance. In this paper, the control of Unmanned Aerial Vehicle (UAV) quadrotor, using two different approaches, is presented. The first controller is Nonlinear PID (NLPID) whilst the second one is Nonlinear Internal Model Control (NLIMC) that are used for the stabilization as well as for the 3D trajectory tracking. The numerical simulations have shown satisfactory results using nominal system model or disturbed model for both of them. The obtained results are analyzed with respect to several criteria for the sake of comparison.

  20. The Witten-Sakai-Sugimoto model: A brief review and some recent results

    Directory of Open Access Journals (Sweden)

    Rebhan Anton

    2015-01-01

    Full Text Available A brief review of the Witten-Sakai-Sugimoto model is given, which is a top-down holographic model of low-energy QCD with chiral quarks derived from type-IIA superstring theory. The main predictions of the model, in particular concerning meson spectra, the gluon condensate, the QCD string tension, the mass of the η′ and of baryons are discussed and compared quantitatively with available experimental and/or lattice results. Then some recent results of potential interest to the physics program at the future FAIR facility are presented: The spectrum of glueballs and their decay rates into pions, and the phase diagram of QCD at finite temperature, density, and magnetic field strength.

  1. Extending positive C-LASS results across multiple instructors and multiple classes of Modeling Instruction

    CERN Document Server

    Brewe, Eric; de la Garza, Jorge; Kramer, Laird H

    2013-01-01

    We report on a multi year study of student attitudes measured with the Colorado Learning Attitudes about Science Survey (C-LASS) in calculus-based introductory physics taught with the Modeling Instruction curriculum. We find that five of six instructors and eight of nine sections using Modeling Instruction showed improved attitudes from pre to post course. Cohen's d effect sizes range from 0.08 to 0.95 for individual instructors. The average effect was d = 0.45, with a 95% confidence interval of (0.26 to 0.64). These results build on previously published results showing positive shifts in attitudes from Modeling Instruction classes. We interpret these data in light of other published positive attitudinal shifts and explore mechanistic explanations for similarities and differences with other published positive shifts.

  2. Influence of Different Modeling Strategies for CFRP on Finite Element Simulation Results

    Directory of Open Access Journals (Sweden)

    Liu Xueshu

    2016-01-01

    Full Text Available Numerical simulation is used to predict the behavior and response of carbon fiber reinforced plastic (CFRP. Sometimes zero thickness of interface layer is introduced into the numerical model to investigate the inter-layer behavior like delamination. To investigate the influence of critical volume-type defect like void, usually appeared in matrix rich region at the interface between layers, on mechanical properties of CFRP, numerical models with different interface thickness were created and tensile property and three-point bending simulation results were compared to experimental ones. It is found that accurate result is obtained with increasing of the interface thickness and up to 20% that of layer thickness is recommended to model the matrix rich region.

  3. Model Parameter Estimation Experiment (MOPEX): Overview and Summary of the Second and Third Workshop Results

    Energy Technology Data Exchange (ETDEWEB)

    Duan, Q; Schaake, J; Andreassian, V; Franks, S; Gupta, H V; Gusev, Y M; Habets, F; Hall, A; Hay, L; Hogue, T; Huang, M; Leavesley, G; Liang, X; Nasonova, O N; Noilhan, J; Oudin, L; Sorooshian, S; Wagener, T; Wood, E F

    2005-02-10

    Model Parameter Estimation Experiment (MOPEX) is an international project aimed to develop enhanced techniques for the a priori estimation of parameters in hydrologic models and in land surface parameterization schemes of atmospheric models. MOPEX science strategy involves three major steps: data preparation, a priori parameter estimation methodology development, and demonstration of parameter transferability. A comprehensive MOPEX database has been developed that contains historical hydrometeorological data and land surface characteristics data for many hydrologic basins in the United States and in other countries. This database is continuing to be expanded to include more basins in all parts of the world. A number of international MOPEX workshops have been convened to bring together interested hydrologists and land surface modelers from all over world to exchange knowledge and experience in developing a priori parameter estimation techniques. This paper describes the results from the second and third MOPEX workshops. The specific objective of those workshops is to examine the state of a priori parameter estimation techniques and how they can be potentially improved with observations from well-monitored hydrologic basins. Participants of these MOPEX workshops were given data for 12 basins in the Southeastern United States and were asked to carry out a series of numerical experiments using a priori parameters as well as calibrated parameters developed for their respective hydrologic models. Eight different models have carried all out the required numerical experiments and the results from those models have been assembled for analysis in this paper. This paper presents an overview of the MOPEX experiment design. The experimental results are analyzed and the important lessons from the two workshops are discussed. Finally, a discussion of further work and future strategy is given.

  4. Results of an interactively coupled atmospheric chemistry - general circulation model. Comparison with observations

    Energy Technology Data Exchange (ETDEWEB)

    Hein, R.; Dameris, M.; Schnadt, C. [and others

    2000-01-01

    An interactively coupled climate-chemistry model which enables a simultaneous treatment of meteorology and atmospheric chemistry and their feedbacks is presented. This is the first model, which interactively combines a general circulation model based on primitive equations with a rather complex model of stratospheric and tropospheric chemistry, and which is computational efficient enough to allow long-term integrations with currently available computer resources. The applied model version extends from the Earth's surface up to 10 hPa with a relatively high number (39) of vertical levels. We present the results of a present-day (1990) simulation and compare it to available observations. We focus on stratospheric dynamics and chemistry relevant to describe the stratospheric ozone layer. The current model version ECHAM4.L39(DLR)/CHEM can realistically reproduce stratospheric dynamics in the Arctic vortex region, including stratospheric warming events. This constitutes a major improvement compared to formerly applied model versions. However, apparent shortcomings in Antarctic circulation and temperatures persist. The seasonal and interannual variability of the ozone layer is simulated in accordance with observations. Activation and deactivation of chlorine in the polar stratospheric vortices and their interhemispheric differences are reproduced. The consideration of the chemistry feedback on dynamics results in an improved representation of the spatial distribution of stratospheric water vapor concentrations, i.e., the simulated meriodional water vapor gradient in the stratosphere is realistic. The present model version constitutes a powerful tool to investigate, for instance, the combined direct and indirect effects of anthropogenic trace gas emissions, and the future evolution of the ozone layer. (orig.)

  5. Results of an interactively coupled atmospheric chemistry - general circulation model. Comparison with observations

    Energy Technology Data Exchange (ETDEWEB)

    Hein, R.; Dameris, M.; Schnadt, C. [and others

    2000-01-01

    An interactively coupled climate-chemistry model which enables a simultaneous treatment of meteorology and atmospheric chemistry and their feedbacks is presented. This is the first model, which interactively combines a general circulation model based on primitive equations with a rather complex model of stratospheric and tropospheric chemistry, and which is computational efficient enough to allow long-term integrations with currently available computer resources. The applied model version extends from the Earth's surface up to 10 hPa with a relatively high number (39) of vertical levels. We present the results of a present-day (1990) simulation and compare it to available observations. We focus on stratospheric dynamics and chemistry relevant to describe the stratospheric ozone layer. The current model version ECHAM4.L39(DLR)/CHEM can realistically reproduce stratospheric dynamics in the Arctic vortex region, including stratospheric warming events. This constitutes a major improvement compared to formerly applied model versions. However, apparent shortcomings in Antarctic circulation and temperatures persist. The seasonal and interannual variability of the ozone layer is simulated in accordance with observations. Activation and deactivation of chlorine in the polar stratospheric vortices and their interhemispheric differences are reproduced. The consideration of the chemistry feedback on dynamics results in an improved representation of the spatial distribution of stratospheric water vapor concentrations, i.e., the simulated meriodional water vapor gradient in the stratosphere is realistic. The present model version constitutes a powerful tool to investigate, for instance, the combined direct and indirect effects of anthropogenic trace gas emissions, and the future evolution of the ozone layer. (orig.)

  6. Optimal Geoid Modelling to determine the Mean Ocean Circulation - Project Overview and early Results

    Science.gov (United States)

    Fecher, Thomas; Knudsen, Per; Bettadpur, Srinivas; Gruber, Thomas; Maximenko, Nikolai; Pie, Nadege; Siegismund, Frank; Stammer, Detlef

    2017-04-01

    The ESA project GOCE-OGMOC (Optimal Geoid Modelling based on GOCE and GRACE third-party mission data and merging with altimetric sea surface data to optimally determine Ocean Circulation) examines the influence of the satellite missions GRACE and in particular GOCE in ocean modelling applications. The project goal is an improved processing of satellite and ground data for the preparation and combination of gravity and altimetry data on the way to an optimal MDT solution. Explicitly, the two main objectives are (i) to enhance the GRACE error modelling and optimally combine GOCE and GRACE [and optionally terrestrial/altimetric data] and (ii) to integrate the optimal Earth gravity field model with MSS and drifter information to derive a state-of-the art MDT including an error assessment. The main work packages referring to (i) are the characterization of geoid model errors, the identification of GRACE error sources, the revision of GRACE error models, the optimization of weighting schemes for the participating data sets and finally the estimation of an optimally combined gravity field model. In this context, also the leakage of terrestrial data into coastal regions shall be investigated, as leakage is not only a problem for the gravity field model itself, but is also mirrored in a derived MDT solution. Related to (ii) the tasks are the revision of MSS error covariances, the assessment of the mean circulation using drifter data sets and the computation of an optimal geodetic MDT as well as a so called state-of-the-art MDT, which combines the geodetic MDT with drifter mean circulation data. This paper presents an overview over the project results with focus on the geodetic results part.

  7. Polarized antiquark distributions from chiral quark-soliton model summary of the results

    CERN Document Server

    Göke, K; Polyakov, M V; Urbano, D

    2000-01-01

    In these short notes we present a parametrization of the results obtained in the chiral quark-soliton model for polarized antiquark distributions $\\Delta\\bar u$, $\\Delta\\bar d$ and $\\Delta\\bar s$ at a low normalization point around mu=0.6 GeV.

  8. Social approval of the community assessment model for odor dispersal: results from a citizen survey.

    Science.gov (United States)

    Tyndall, John C; Grudens-Schuck, Nancy; Harmon, Jay D; Hoff, Steve J

    2012-08-01

    Odors emitted from US Midwest hog production facilities present farmers, residents, and state regulatory agencies with a set of complex challenges. To predict odor exposure from multiple swine production sources simultaneously, and to determine siting recommendations for proposed new or enlarged hog facilities, researchers at Iowa State University designed the community assessment model for odor dispersion (CAM). A three-county citizen survey conducted in Iowa examined the level of hypothetical social acceptance of the modeling process, and level of trust in CAM results. While 69 % of respondents approved of modeling as a way to determine the most socially appropriate location for production sites, only 35 % would trust the results if potential odor exposure from a new facility were proposed to be built near their home. We analyzed approval of the CAM model, and level of trust, across a number of demographic, attitudinal, and belief factors regarding environmental quality and the hog industry. Overall, trust in CAM was uneven and varied across respondents. Those residents who would not trust CAM tended to be more concerned with environmental quality and less inclined to believe that the hog industry is critically important economically. Those who would not trust CAM results also had significantly more direct experience with odors. Findings point to predominantly positive, yet equivocal acceptance of CAM results among the citizenry, which is not unexpected given conflict typical of siting decisions in industry and waste disposal arenas. Recommendations are offered regarding the interaction of trust, beliefs and attitudes and the utility of CAM.

  9. Modeling of contact mechanics and friction limit surfaces for soft fingers in robotics, with experimental results

    Energy Technology Data Exchange (ETDEWEB)

    Xydas, N.; Kao, I.

    1999-09-01

    A new theory in contact mechanics for modeling of soft fingers is proposed to define the relationship between the normal force and the radius of contact for soft fingers by considering general soft-finger materials, including linearly and nonlinearly elastic materials. The results show that the radius of contact is proportional to the normal force raised to the power of {gamma}, which ranges from 0 to 1/3. This new theory subsumes the Hertzian contact model for linear elastic materials, where {gamma} = 1/3. Experiments are conducted to validate the theory using artificial soft fingers made of various materials such as rubber and silicone. Results for human fingers are also compared. This theory provides a basis for numerically constructing friction limit surfaces. The numerical friction limit surface can be approximated by an ellipse, with the major and minor axes as the maximum friction force and the maximum moment with respect to the normal axis of contact, respectively. Combining the results of the contact-mechanics model with the contact-pressure distribution, the normalized friction limit surface can be derived for anthropomorphic soft fingers. The results of the contact-mechanics model and the pressure distribution for soft fingers facilitate the construction of numerical friction limit surfaces, and will enable us to analyze and simulate contact behaviors of grasping and manipulation in robotics.

  10. From sub-source to source: Interpreting results of biological trace investigations using probabilistic models

    NARCIS (Netherlands)

    Oosterman, W.T.; Kokshoorn, B.; Maaskant-van Wijk, P.A.; de Zoete, J.

    2015-01-01

    The current method of reporting a putative cell type is based on a non-probabilistic assessment of test results by the forensic practitioner. Additionally, the association between donor and cell type in mixed DNA profiles can be exceedingly complex. We present a probabilistic model for interpretatio

  11. Results from the beam test of the engineering model of the GLAST large area telescope

    Energy Technology Data Exchange (ETDEWEB)

    Couto e Silva, E. do E-mail: eduardo@slac.stanford.edu; Anthony, P.; Arnold, R.; Arrighi, H.; Bloom, E.; Baughman, B.; Bogart, J.; Bosted, P.; Bumala, B.; Chekhtman, A.; Cotton, N.; Crider, A.; Dobbs-Dixon, I.; Djannati-Atai, A.; Dubois, R.; Engovatov, D.; Espigat, P.; Evans, J.L.; Fieguth, T.; Flath, D.; Frigaard, M.; Giebels, B.; Gillespie, S.; Godfrey, G.; Grove, J.E.; Handa, T.; Hansl-Kozanecka, T.; Hernando, J.; Hicks, M.; Hirayama, M.; Johnson, W.N.; Johnson, R.; Kamae, T.; Kroeger, W.; Lauben, D.; Lin, Y.C.; Lindner, T.; Michelson, P.; Moiseev, A.; Nikolaou, M.; Nolan, P.; Odian, A.; Ohsugi, T.; Ormes, J.; Paliaga, G.; Parkinson, P. Saz; Phlips, B.; Ritz, S.; Rock, S.; Russel, J.J.; Sadrozinski, H.; Schalk, T.; Silvis, J.; Szalata, Z.; Terrier, R.; Thompson, D.J.; Tournear, D.M.; Waite, A.P.; Wallace, J.; Williams, S.; Williamson, R.; Winker, G

    2001-11-21

    This paper describes the results of a beam test using the Engineering Model of the GLAST Large Area Telescope, which was installed in a beam of positrons, hadrons and tagged photons at SLAC. The performance of the four subsystems, Anti Coincidence Detector, Silicon Tracker, Calorimeter and Data Acquisition will be described.

  12. An example of model result correction to study the impact of climate change on electricity consumption

    Science.gov (United States)

    Parey, S.; Galloy, G.; Nogaj, M.

    2012-04-01

    Climate is changing and temperature evolutions are thought to impact electricity consumption in the future. In order to estimate these possible shifts, climate model results for two future periods: 2050 and 2100 are considered. However, the use of the electricity consumption forecast model with climate model outputs for the current period give unrealistic results compared to forecasts made with observations. As a matter of fact, consumption is forecasted using a taylor-designed mean of French temperatures. Therefore, it is necessary for the model results to be as close as possible to this observed mean. The first studies had been made using the so-called "delta method", which consists in adding future changes to the observations. This however supposes that there is no variance change, which is not necessarily valid. Thus, in a second step, the percentile correction method has been used, firstly considering the whole annual distribution. This is however not satisfactory, as the seasonal distributions remain too much biased. Thus, the correction had to be applied on a monthly basis. The method and results of the correction will be presented for this example of France.

  13. V-SUIT Model Validation Using PLSS 1.0 Test Results

    Science.gov (United States)

    Olthoff, Claas

    2015-01-01

    The dynamic portable life support system (PLSS) simulation software Virtual Space Suit (V-SUIT) has been under development at the Technische Universitat Munchen since 2011 as a spin-off from the Virtual Habitat (V-HAB) project. The MATLAB(trademark)-based V-SUIT simulates space suit portable life support systems and their interaction with a detailed and also dynamic human model, as well as the dynamic external environment of a space suit moving on a planetary surface. To demonstrate the feasibility of a large, system level simulation like V-SUIT, a model of NASA's PLSS 1.0 prototype was created. This prototype was run through an extensive series of tests in 2011. Since the test setup was heavily instrumented, it produced a wealth of data making it ideal for model validation. The implemented model includes all components of the PLSS in both the ventilation and thermal loops. The major components are modeled in greater detail, while smaller and ancillary components are low fidelity black box models. The major components include the Rapid Cycle Amine (RCA) CO2 removal system, the Primary and Secondary Oxygen Assembly (POS/SOA), the Pressure Garment System Volume Simulator (PGSVS), the Human Metabolic Simulator (HMS), the heat exchanger between the ventilation and thermal loops, the Space Suit Water Membrane Evaporator (SWME) and finally the Liquid Cooling Garment Simulator (LCGS). Using the created model, dynamic simulations were performed using same test points also used during PLSS 1.0 testing. The results of the simulation were then compared to the test data with special focus on absolute values during the steady state phases and dynamic behavior during the transition between test points. Quantified simulation results are presented that demonstrate which areas of the V-SUIT model are in need of further refinement and those that are sufficiently close to the test results. Finally, lessons learned from the modelling and validation process are given in combination

  14. Extract from Ceratonia siliqua Exhibits Depigmentation Properties.

    Science.gov (United States)

    Lall, Namrita; Kishore, Navneet; Momtaz, Saeideh; Hussein, Ahmed; Naidoo, Sanushka; Nqephe, Mabatho; Crampton, Bridget

    2015-11-01

    Skin hyper-pigmentation is a condition initiated by the overproduction of melanin existing in the melanocytes. Melanin pigment is responsible for the colour of skin in humans. It is formed through a series of oxidative reactions involving the amino acid tyrosine in the presence of the key enzyme tyrosinase. In continuation with our efforts to identify tyrosinase inhibitors from plants sources, the methanol extract from leaf, bark and fruit of Ceratonia siliqua were screened for tyrosinase inhibition and diphenolase activity. The bark extract exhibited significant inhibition on mushroom tyrosinase using L-tyrosine as a substrate and showed diphenolase activity. The extract further significantly lowered tyrosinase mRNA levels in B16-F10 mouse melanocytes. Bioassay-guided fractionation led to the isolation of six compounds. Compounds (-)-epicatechin-3-O-gallate, 1,2,3,6-tetra-O-galloyl-ß-D-glucose and gallocatechin-3-O-gallate showed tyrosinase inhibitions with the IC50 values of 27.52, 83.30 and 28.30 µg/mL, respectively. These compounds also exhibited L-DOPA activities with IC50 values of >200, 150 and 200 µg/mL, respectively. A clinical study was conducted using 20 volunteers in a patch testing trial for irritancy potential and skin depigmentation. The clinical results showed the sample to be non-irritant with irritancy potential of -34.21 and depigmentation trial showed an improvement in the even skin tone of UV induced pigmentation at 3% after 28 days of application.

  15. Comparing Simulation Results with Traditional PRA Model on a Boiling Water Reactor Station Blackout Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Zhegang Ma; Diego Mandelli; Curtis Smith

    2011-07-01

    A previous study used RELAP and RAVEN to conduct a boiling water reactor station black-out (SBO) case study in a simulation based environment to show the capabilities of the risk-informed safety margin characterization methodology. This report compares the RELAP/RAVEN simulation results with traditional PRA model results. The RELAP/RAVEN simulation run results were reviewed for their input parameters and output results. The input parameters for each simulation run include various timing information such as diesel generator or offsite power recovery time, Safety Relief Valve stuck open time, High Pressure Core Injection or Reactor Core Isolation Cooling fail to run time, extended core cooling operation time, depressurization delay time, and firewater injection time. The output results include the maximum fuel clad temperature, the outcome, and the simulation end time. A traditional SBO PRA model in this report contains four event trees that are linked together with the transferring feature in SAPHIRE software. Unlike the usual Level 1 PRA quantification process in which only core damage sequences are quantified, this report quantifies all SBO sequences, whether they are core damage sequences or success (i.e., non core damage) sequences, in order to provide a full comparison with the simulation results. Three different approaches were used to solve event tree top events and quantify the SBO sequences: “W” process flag, default process flag without proper adjustment, and default process flag with adjustment to account for the success branch probabilities. Without post-processing, the first two approaches yield incorrect results with a total conditional probability greater than 1.0. The last approach accounts for the success branch probabilities and provides correct conditional sequence probabilities that are to be used for comparison. To better compare the results from the PRA model and the simulation runs, a simplified SBO event tree was developed with only four

  16. Implementing a continuum of care model for older people - results from a Swedish case study

    Directory of Open Access Journals (Sweden)

    Anna Duner

    2011-11-01

    Full Text Available Introduction: There is a need for integrated care and smooth collaboration between care-providing organisations and professions to create a continuum of care for frail older people. However, collaboration between organisations and professions is often problematic. The aim of this study was to examine the process of implementing a new continuum of care model in a complex organisational context, and illuminate some of the challenges involved. The introduced model strived to connect three organisations responsible for delivering health and social care to older people: the regional hospital, primary health care and municipal eldercare.Methods: The actions of the actors involved in the process of implementing the model were understood to be shaped by the actors' understanding, commitment and ability. This article is based on 44 qualitative interviews performed on four occasions with 26 key actors at three organisational levels within these three organisations.Results and conclusions: The results point to the importance of paying regard to the different cultures of the organisations when implementing a new model. The role of upper management emerged as very important. Furthermore, to be accepted, the model has to be experienced as effectively dealing with real problems in the everyday practice of the actors in the organisations, from the bottom to the top.

  17. Implementing a continuum of care model for older people - results from a Swedish case study

    Directory of Open Access Journals (Sweden)

    Anna Duner

    2011-11-01

    Full Text Available Introduction: There is a need for integrated care and smooth collaboration between care-providing organisations and professions to create a continuum of care for frail older people. However, collaboration between organisations and professions is often problematic. The aim of this study was to examine the process of implementing a new continuum of care model in a complex organisational context, and illuminate some of the challenges involved. The introduced model strived to connect three organisations responsible for delivering health and social care to older people: the regional hospital, primary health care and municipal eldercare. Methods: The actions of the actors involved in the process of implementing the model were understood to be shaped by the actors' understanding, commitment and ability. This article is based on 44 qualitative interviews performed on four occasions with 26 key actors at three organisational levels within these three organisations. Results and conclusions: The results point to the importance of paying regard to the different cultures of the organisations when implementing a new model. The role of upper management emerged as very important. Furthermore, to be accepted, the model has to be experienced as effectively dealing with real problems in the everyday practice of the actors in the organisations, from the bottom to the top.

  18. Europa's surface composition from near-infrared observations: A comparison of results from linear mixture modeling and radiative transfer modeling

    Science.gov (United States)

    Shirley, James H.; Jamieson, Corey S.; Dalton, J. Bradley

    2016-08-01

    Quantitative estimates of the abundance of surface materials and of water ice particle grain sizes at five widely separated locations on the surface of Europa have been obtained by two independent methods in order to search for possible discrepancies that may be attributed to differences in the methods employed. Results of radiative transfer (RT) compositional modeling (also known as intimate mixture modeling) from two prior studies are here employed without modification. Areal (or "checkerboard") mixture modeling, also known as linear mixture (LM) modeling, was performed to allow direct comparisons. The failure to model scattering processes (whose effects may be strongly nonlinear) in the LM approach is recognized as a potential source of errors. RT modeling accounts for nonlinear spectral responses due to scattering but is subject to other uncertainties. By comparing abundance estimates for H2SO4 · nH2O and water ice, obtained through both methods as applied to identical spectra, we may gain some insight into the importance of "volume scattering" effects for investigations of Europa's surface composition. We find that both methods return similar abundances for each location analyzed; linear correlation coefficients of ≥ 0.98 are found between the derived H2SO4 · nH2O and water ice abundances returned by both methods. We thus find no evidence of a significant influence of volume scattering on the compositional solutions obtained by LM modeling for these locations. Some differences in the results obtained for water ice grain sizes are attributed to the limited selection of candidate materials allowed in the RT investigations.

  19. Determination of mechanical properties from depth-sensing indentation data and results of finite element modeling

    Science.gov (United States)

    Isaenkova, M. G.; Perlovich, Yu A.; Krymskaya, O. A.; Zhuk, D. I.

    2016-04-01

    3D finite element model of indentation process with Berkovich tip was created. Using this model with different type of test materials, several series of calculations were made. These calculations lead to determination of material behavior features during indentation. Relations between material properties and its behavior during instrumented indentation were used for construction of dimensionless functions required for development the calculation algorithm, suitable to determine mechanical properties of materials by results of the depth-sensing indentation. Results of mechanical properties determination using elaborated algorithm for AISI 1020 steel grade were compared to properties obtained with standard compression tests. These two results differ by less than 10% for yield stress that evidence of a good accuracy of the proposed technique.

  20. MESSOC capabilities and results. [Model for Estimating Space Station Opertions Costs

    Science.gov (United States)

    Shishko, Robert

    1990-01-01

    MESSOC (Model for Estimating Space Station Operations Costs) is the result of a multi-year effort by NASA to understand and model the mature operations cost of Space Station Freedom. This paper focuses on MESSOC's ability to contribute to life-cycle cost analyses through its logistics equations and databases. Together, these afford MESSOC the capability to project not only annual logistics costs for a variety of Space Station scenarios, but critical non-cost logistics results such as annual Station maintenance crewhours, upweight/downweight, and on-orbit sparing availability as well. MESSOC results using current logistics databases and baseline scenario have already shown important implications for on-orbit maintenance approaches, space transportation systems, and international operations cost sharing.

  1. Solar Deployment System (SolarDS) Model: Documentation and Sample Results

    Energy Technology Data Exchange (ETDEWEB)

    Denholm, P.; Drury, E.; Margolis, R.

    2009-09-01

    The Solar Deployment System (SolarDS) model is a bottom-up, market penetration model that simulates the potential adoption of photovoltaics (PV) on residential and commercial rooftops in the continental United States through 2030. NREL developed SolarDS to examine the market competitiveness of PV based on regional solar resources, capital costs, electricity prices, utility rate structures, and federal and local incentives. The model uses the projected financial performance of PV systems to simulate PV adoption for building types and regions then aggregates adoption to state and national levels. The main components of SolarDS include a PV performance simulator, a PV annual revenue calculator, a PV financial performance calculator, a PV market share calculator, and a regional aggregator. The model simulates a variety of installed PV capacity for a range of user-specified input parameters. PV market penetration levels from 15 to 193 GW by 2030 were simulated in preliminary model runs. SolarDS results are primarily driven by three model assumptions: (1) future PV cost reductions, (2) the maximum PV market share assumed for systems with given financial performance, and (3) PV financing parameters and policy-driven assumptions, such as the possible future cost of carbon emissions.

  2. Ross ice shelf cavity circulation, residence time, and melting: Results from a model of oceanic chlorofluorocarbons

    Science.gov (United States)

    Reddy, Tasha E.; Holland, David M.; Arrigo, Kevin R.

    2010-04-01

    Despite their harmful effects in the upper atmosphere, anthropogenic chlorofluorocarbons dissolved in seawater are extremely useful for studying ocean circulation and ventilation, particularly in remote locations. Because they behave as a passive tracer in seawater, and their atmospheric concentrations are well-mixed, well-known, and have changed over time, they are ideal for gaining insight into the oceanographic characteristics of the isolated cavities found under Antarctic ice shelves, where direct observations are difficult to obtain. Here we present results from a modeling study of air-sea chlorofluorocarbon exchange and ocean circulation in the Ross Sea, Antarctica. We compare our model estimates of oceanic CFC-12 concentrations along an ice shelf edge transect to field data collected during three cruises spanning 16 yr. Our model produces chlorofluorocarbon concentrations that are quite similar to those measured in the field, both in magnitude and distribution, showing high values near the surface, decreasing with depth, and increasing over time. After validating modeled circulation and air-sea gas exchange through comparison of modeled temperature, salinity, and chlorofluorocarbons with field data, we estimate that the residence time of water in the Ross Ice Shelf cavity is approximately 2.2 yr and that basal melt rates for the ice shelf average 10 cm yr -1. The model predicts a seasonal signature to basal melting, with highest melt rates in the spring and also the fall.

  3. Assessment of Energy Removal Impacts on Physical Systems: Hydrodynamic Model Domain Expansion and Refinement, and Online Dissemination of Model Results

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zhaoqing; Khangaonkar, Tarang; Wang, Taiping

    2010-08-01

    In this report we describe the 1) the expansion of the PNNL hydrodynamic model domain to include the continental shelf along the coasts of Washington, Oregon, and Vancouver Island; and 2) the approach and progress in developing the online/Internet disseminations of model results and outreach efforts in support of the Puget Sound Operational Forecast System (PS-OPF). Submittal of this report completes the work on Task 2.1.2, Effects of Physical Systems, Subtask 2.1.2.1, Hydrodynamics, for fiscal year 2010 of the Environmental Effects of Marine and Hydrokinetic Energy project.

  4. Energy consumption and economic growth in New Zealand. Results of trivariate and multivariate models

    Energy Technology Data Exchange (ETDEWEB)

    Bartleet, Matthew; Gounder, Rukmani [Department of Economics and Finance, Massey University, Palmerston North (New Zealand)

    2010-07-15

    This study examines the energy consumption-growth nexus in New Zealand. Causal linkages between energy and macroeconomic variables are investigated using trivariate demand-side and multivariate production models. Long run and short run relationships are estimated for the period 1960-2004. The estimated results of demand model reveal a long run relationship between energy consumption, real GDP and energy prices. The short run results indicate that real GDP Granger-causes energy consumption without feedback, consistent with the proposition that energy demand is a derived demand. Energy prices are found to be significant for energy consumption outcomes. Production model results indicate a long run relationship between real GDP, energy consumption and employment. The Granger-causality is found from real GDP to energy consumption, providing additional evidence to support the neoclassical proposition that energy consumption in New Zealand is fundamentally driven by economic activities. Inclusion of capital in the multivariate production model shows short run causality from capital to energy consumption. Also, changes in real GDP and employment have significant predictive power for changes in real capital. (author)

  5. Energy consumption and economic growth in New Zealand: Results of trivariate and multivariate models

    Energy Technology Data Exchange (ETDEWEB)

    Bartleet, Matthew [Department of Economics and Finance, Massey University, Palmerston North (New Zealand); Gounder, Rukmani, E-mail: R.Gounder@massey.ac.n [Department of Economics and Finance, Massey University, Palmerston North (New Zealand)

    2010-07-15

    This study examines the energy consumption-growth nexus in New Zealand. Causal linkages between energy and macroeconomic variables are investigated using trivariate demand-side and multivariate production models. Long run and short run relationships are estimated for the period 1960-2004. The estimated results of demand model reveal a long run relationship between energy consumption, real GDP and energy prices. The short run results indicate that real GDP Granger-causes energy consumption without feedback, consistent with the proposition that energy demand is a derived demand. Energy prices are found to be significant for energy consumption outcomes. Production model results indicate a long run relationship between real GDP, energy consumption and employment. The Granger-causality is found from real GDP to energy consumption, providing additional evidence to support the neoclassical proposition that energy consumption in New Zealand is fundamentally driven by economic activities. Inclusion of capital in the multivariate production model shows short run causality from capital to energy consumption. Also, changes in real GDP and employment have significant predictive power for changes in real capital.

  6. Results comparison and model validation for flood loss functions in Australian geographical conditions

    Science.gov (United States)

    Hasanzadeh Nafari, R.; Ngo, T.; Lehman, W.

    2015-06-01

    Rapid urbanisation, climate change and unsustainable developments are increasing the risk of floods, namely flood frequency and intensity. Flood is a frequent natural hazard that has significant financial consequences for Australia. The emergency response system in Australia is very successful and has saved many lives over the years. However, the preparedness for natural disaster impacts in terms of loss reduction and damage mitigation has been less successful. This study aims to quantify the direct physical damage to residential structures that are prone to flood phenomena in Australia. In this paper, the physical consequences of two floods from Queensland have been simulated, and the results have been compared with the performance of two selected methodologies and one newly derived model. Based on this analysis, the adaptability and applicability of the selected methodologies will be assessed in terms of Australian geographical conditions. Results obtained from the new empirically-based function and non-adapted methodologies indicate that it is apparent that the precision of flood damage models are strongly dependent on selected stage damage curves, and flood damage estimation without model validation results in inaccurate prediction of losses. Therefore, it is very important to be aware of the associated uncertainties in flood risk assessment, especially if models have not been adapted with real damage data.

  7. A Module for Graphical Display of Model Results with the CBP Toolbox

    Energy Technology Data Exchange (ETDEWEB)

    Smith, F. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-04-21

    This report describes work performed by the Savannah River National Laboratory (SRNL) in fiscal year 2014 to add enhanced graphical capabilities to display model results in the Cementitious Barriers Project (CBP) Toolbox. Because Version 2.0 of the CBP Toolbox has just been released, the graphing enhancements described in this report have not yet been integrated into a new version of the Toolbox. Instead they have been tested using a standalone GoldSim model and, while they are substantially complete, may undergo further refinement before full implementation. Nevertheless, this report is issued to document the FY14 development efforts which will provide a basis for further development of the CBP Toolbox.

  8. MHD Model Results of Solar Wind Plasma Interaction with Mars and Comparison with MAVEN Observations

    Science.gov (United States)

    Ma, Y. J.; Russell, C. T.; Nagy, A. F.; Toth, G.; Halekas, J. S.; Connerney, J. E. P.; Espley, J. R.; Mahaffy, P. R.

    2015-01-01

    The crustal remnant field on Mars rotates constantly with the planet, varying the magnetic field configuration interacting with the solar wind. It has been found that ion loss rates slowly vary with the subsolar longitude, anticorrelating with the intensity of the dayside crustal field source, with some time delay, using a time-dependent multispecies MHD model. In this study, we investigate in detail how plasma properties are influenced locally by the crustal field and its rotation. Model results will be compared in detail with plasma observations from MAVEN.

  9. Warm (λ/4)ϕ{sup 4} inflationary universe model in light of Planck 2015 results

    Energy Technology Data Exchange (ETDEWEB)

    Panotopoulos, Grigorios, E-mail: gpanotop@ing.uchile.cl; Videla, Nelson, E-mail: nelson.videlamenares@gmail.com [Departamento de Física, FCFM, Universidad de Chile, Blanco Encalada 2008, Santiago (Chile)

    2015-11-04

    In the present work we show that warm chaotic inflation characterized by a simple (λ/4)ϕ{sup 4} self-interaction potential for the inflaton, excluded by current data in standard cold inflation, and by an inflaton decay rate proportional to the temperature, is in agreement with the latest Planck data. The parameters of the model are constrained, and our results show that the model predicts a negligible tensor-to-scalar ratio in the strong dissipative regime, while in the weak dissipative regime the tensor-to-scalar ratio can be large enough to be observed.

  10. Warm (λ)/(4)φ{sup 4} inflationary universe model in light of Planck 2015 results

    Energy Technology Data Exchange (ETDEWEB)

    Panotopoulos, Grigorios; Videla, Nelson [Universidad de Chile, Departamento de Fisica, FCFM, Santiago (Chile)

    2015-11-15

    In the present work we show that warm chaotic inflation characterized by a simple (λ)/(4)φ{sup 4} self-interaction potential for the inflaton, excluded by current data in standard cold inflation, and by an inflaton decay rate proportional to the temperature, is in agreement with the latest Planck data. The parameters of the model are constrained, and our results show that the model predicts a negligible tensor-to-scalar ratio in the strong dissipative regime, while in the weak dissipative regime the tensor-to-scalar ratio can be large enough to be observed. (orig.)

  11. First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G. [Fermilab; Chlachidze, G. [Fermilab; Wanderer, P. [Brookhaven; Ferracin, P. [CERN; Sabbi, G. [LBNL, Berkeley

    2016-10-06

    The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb3Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to address them are also presented and discussed.

  12. Some exact results on the Potts model partition function in a magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S-C [Department of Physics, National Cheng Kung University, Tainan 70101, Taiwan (China); Shrock, Robert [C N Yang Institute for Theoretical Physics, Stony Brook University, Stony Brook, NY 11794 (United States)], E-mail: scchang@mail.ncku.edu.tw, E-mail: robert.shrock@stonybrook.edu

    2009-09-25

    We consider the Potts model in a magnetic field on an arbitrary graph G. Using a formula by F Y Wu for the partition function Z of this model as a sum over spanning subgraphs of G, we prove some properties of Z concerning factorization, monotonicity and zeros. A generalization of the Tutte polynomial is presented that corresponds to this partition function. In this context, we formulate and discuss two weighted graph-coloring problems. We also give a general structural result for Z for cyclic strip graphs.

  13. Some exact results on the Potts model partition function in a magnetic field

    Science.gov (United States)

    Chang, Shu-Chiuan; Shrock, Robert

    2009-09-01

    We consider the Potts model in a magnetic field on an arbitrary graph G. Using a formula by F Y Wu for the partition function Z of this model as a sum over spanning subgraphs of G, we prove some properties of Z concerning factorization, monotonicity and zeros. A generalization of the Tutte polynomial is presented that corresponds to this partition function. In this context, we formulate and discuss two weighted graph-coloring problems. We also give a general structural result for Z for cyclic strip graphs.

  14. Modeling the Fracturing of Rock by Fluid Injection - Comparison of Numerical and Experimental Results

    Science.gov (United States)

    Heinze, Thomas; Galvan, Boris; Miller, Stephen

    2013-04-01

    Fluid-rock interactions are mechanically fundamental to many earth processes, including fault zones and hydrothermal/volcanic systems, and to future green energy solutions such as enhanced geothermal systems and carbon capture and storage (CCS). Modeling these processes is challenging because of the strong coupling between rock fracture evolution and the consequent large changes in the hydraulic properties of the system. In this talk, we present results of a numerical model that includes poro-elastic plastic rheology (with hardening, softening, and damage), and coupled to a non-linear diffusion model for fluid pressure propagation and two-phase fluid flow. Our plane strain model is based on the poro- elastic plastic behavior of porous rock and is advanced with hardening, softening and damage using the Mohr- Coulomb failure criteria. The effective stress model of Biot (1944) is used for coupling the pore pressure and the rock behavior. Frictional hardening and cohesion softening are introduced following Vermeer and de Borst (1984) with the angle of internal friction and the cohesion as functions of the principal strain rates. The scalar damage coefficient is assumed to be a linear function of the hardening parameter. Fluid injection is modeled as a two phase mixture of water and air using the Richards equation. The theoretical model is solved using finite differences on a staggered grid. The model is benchmarked with experiments on the laboratory scale in which fluid is injected from below in a critically-stressed, dry sandstone (Stanchits et al. 2011). We simulate three experiments, a) the failure a dry specimen due to biaxial compressive loading, b) the propagation a of low pressure fluid front induced from the bottom in a critically stressed specimen, and c) the failure of a critically stressed specimen due to a high pressure fluid intrusion. Comparison of model results with the fluid injection experiments shows that the model captures most of the experimental

  15. Preliminary Results from Electric Arc Furnace Off-Gas Enthalpy Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Nimbalkar, Sachin U [ORNL; Thekdi, Arvind [E3M Inc; Keiser, James R [ORNL; Storey, John Morse [ORNL

    2015-01-01

    This article describes electric arc furnace (EAF) off-gas enthalpy models developed at Oak Ridge National Laboratory (ORNL) to calculate overall heat availability (sensible and chemical enthalpy) and recoverable heat values (steam or power generation potential) for existing EAF operations and to test ORNL s new EAF waste heat recovery (WHR) concepts. ORNL s new EAF WHR concepts are: Regenerative Drop-out Box System and Fluidized Bed System. The two EAF off-gas enthalpy models described in this paper are: 1.Overall Waste Heat Recovery Model that calculates total heat availability in off-gases of existing EAF operations 2.Regenerative Drop-out Box System Model in which hot EAF off-gases alternately pass through one of two refractory heat sinks that store heat and then transfer it to another gaseous medium These models calculate the sensible and chemical enthalpy of EAF off-gases based on the off-gas chemical composition, temperature, and mass flow rate during tap to tap time, and variations in those parameters in terms of actual values over time. The models provide heat transfer analysis for the aforementioned concepts to confirm the overall system and major component sizing (preliminary) to assess the practicality of the systems. Real-time EAF off-gas composition (e.g., CO, CO2, H2, and H2O), volume flow, and temperature data from one EAF operation was used to test the validity and accuracy of the modeling work. The EAF off-gas data was used to calculate the sensible and chemical enthalpy of the EAF off-gases to generate steam and power. The article provides detailed results from the modeling work that are important to the success of ORNL s EAF WHR project. The EAF WHR project aims to develop and test new concepts and materials that allow cost-effective recovery of sensible and chemical heat from high-temperature gases discharged from EAFs.

  16. Artefacts and the performance of an exhibition

    DEFF Research Database (Denmark)

    Svabo, Connie

    2008-01-01

    The article explores the role of mediating artefacts in children's encounters with a museum of natural history. Using actor network theory it explores how a specific artefact shapes the way users relate to exhibited objects and how the artefact guides users' movements in the exhibition. The media...

  17. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  18. Exhibition Economy Set to Boost City Development

    Institute of Scientific and Technical Information of China (English)

    Li Zhen

    2010-01-01

    @@ Awell-developed exhibition industry is usually regarded as an important cri terion in measuring a city's economic and social development level. In recent years, much attention has been paid to exhibition economy for its positive effect on dining, transportation, tourism, advertising, and shopping.

  19. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  20. Full waveform tomography for lithospheric imaging: results from a blind test in a realistic crustal model

    Science.gov (United States)

    Brenders, A. J.; Pratt, R. G.

    2007-01-01

    A comprehensive validation of 2-D, frequency-domain, acoustic wave-equation tomography was undertaken in a `blind test', using third-party, realistic, elastic wave-equation data. The synthetic 2-D, wide-angle seismic data were provided prior to a recent workshop on the methods of controlled source seismology; the true model was not revealed to the authors until after the presentation of our waveform tomography results. The original model was specified on a detailed grid with variable P-wave velocity, S-wave velocity, density and viscoelastic Q-factor structure, designed to simulate a section of continental crust 250 km long and 40 km deep. Synthetic vertical and horizontal component data were available for 51 shot locations (spaced every 5 km), recorded at 2779 receivers (spaced every 90 m), evenly spread along the surface of the model. The data contained energy from 0.2 to 15 Hz. Waveform tomography, a combination of traveltime tomography and 2-D waveform inversion of the early arrivals of the seismic waveforms, was used to recover crustal P-velocity structure from the vertical component data, using data from 51 sources, 1390 receivers and frequencies between 0.8 and 7.0 Hz. The waveform tomography result contained apparent structure at wavelength-scale resolution that was not evident on the traveltime tomography result. The predicted (acoustic) waveforms in the final result matched the original elastic data to a high degree of accuracy. During the workshop, the exact model was revealed; over much of the model the waveform tomography results provided a good correspondence with the true model, from large- to intermediate-(wavelength) scales, with a resolution limit on the order of 1 km. A significant, near-surface low-velocity zone, invisible to traveltime methods, was correctly recovered; the results also provided a high-resolution image of the complex structure of the entire crust, and the depth and nature of the crust-mantle transition. Some inaccuracies were

  1. Exhibition-based Immersive Performance Environments

    DEFF Research Database (Denmark)

    Svabo, Connie

    2017-01-01

    Art”. This exhibition concept has been awarded the prize “Bikubens Udstillings Visionspris” 2016 for its innovative take on exhibitions. In the Sister’s Academy Boarding School visitors ‘move into’ and inhabit an exhibition for a longer period of time, for example 24 or 48 hours. This radically breaks...... with the conventional 1½ hour duration of museum visits and creates new possibilities of and challenges for presence in museums. The paper analyzes exhibition experience as an engagement, which with its immersive and emergent qualities, radically breaks with visual modes of appreciation. The visitor does not ‘stand...... to the everyday and to conventional modes of being, interaction and communication. The exhibition thus becomes a space of potential; a critical and utopian space for trying out new forms of being and new modes of engagement. Theoretically the paper focuses on Berleant’s environmental aesthetics and the notion...

  2. The Culture of Exhibitions and Conservation

    Directory of Open Access Journals (Sweden)

    Dimitrios Doumas

    2013-11-01

    Full Text Available The article reflects on temporary exhibitions from a theoretical as well as practical perspective. Regarded as a particularly effective mass-communication medium, exhibitions have a dual nature: they are scholarly undertakings, bringing off a curator’s vision and, simultaneously, they are projects with economic implications that need to be well managed and administered. The role of conservation in the making of temporary exhibitions, either in-house or touring, is here discussed in relation to how work is planned and prioritized as well as how time is managed and staff is allocated. Reference to weaknesses that lessen the crucial input of conservation in the decision-making process is also made. Much of the debate, which focuses on art exhibitions, concerns practicalities encountered in a private museum that extend from the very early stages of selecting objects for display to the mounting of an exhibition.

  3. High Quality Virtual Reality for Architectural Exhibitions

    DEFF Research Database (Denmark)

    Kreutzberg, Anette

    2016-01-01

    This paper will summarise the findings from creating and implementing a visually high quality Virtual Reality (VR) experiment as part of an international architecture exhibition. It was the aim to represent the architectural spatial qualities as well as the atmosphere created from combining natural...... and artificial lighting in a prominent not yet built project. The outcome is twofold: Findings concerning the integration of VR in an exhibition space and findings concerning the experience of the virtual space itself. In the exhibition, an important aspect was the unmanned exhibition space, requiring the VR...... and quantitative methods at two different occasions and setups after the exhibition, both showing a high degree of immersion and experience of reality....

  4. Holland at CERN – Industrial exhibition

    CERN Multimedia

    GS Department

    2010-01-01

    Sponsored by EVD, an agency of the Dutch Ministry of the Economy From 8 to 11 November 2010 Industrial Exhibition Administration Building Bldg. 61 9-00 - 17-30 Twenty seven companies will present their latest technology at the industrial exhibition "Holland at CERN". Dutch industry will exhibit products and technologies which are related to the field of particle physics. Individual interviews will take place directly at the stands in the Main Building. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details which are available from each departmental secretariat or at the following URL: http://gs-dep.web.cern.ch/gs-dep/groups/sem/ls/Industrial_Exhibitions.htm#Industrial_exhibitions You will find the list of exhibitors below. LIST OF EXHIBITORS: Schelde Exotech Vernooy BV Triumph Group INCAA Computers DeMaCo Holland bv TNO Science & Industry Janssen Precision Engi...

  5. A Comparison of TWP-ICE Observational Data with Cloud-Resolving Model Results

    Energy Technology Data Exchange (ETDEWEB)

    Fridlind, A. M.; Ackerman, Andrew; Chaboureau, Jean-Pierre; Fan, Jiwen; Grabowski, Wojciech W.; Hill, A.; Jones, T. R.; Khaiyer, M. M.; Liu, G.; Minnis, Patrick; Morrison, H.; Nguyen, L.; Park, S.; Petch, Jon C.; Pinty, Jean-Pierre; Schumacher, Courtney; Shipway, Ben; Varble, A. C.; Wu, Xiaoqing; Xie, Shaocheng; Zhang, Minghua

    2012-03-13

    Observations made during the TWP-ICE campaign are used to drive and evaluate thirteen cloud-resolving model simulations with periodic lateral boundary conditions. The simulations employ 2D and 3D dynamics, one- and two-moment microphysics, several variations on large-scale forcing, and the use of observationally derived aerosol properties to prognose droplet numbers. When domain means are averaged over a 6-day active monsoon period, all simulations reproduce observed surface precipitation rate but not its structural distribution. Simulated fractional areas covered by convective and stratiform rain are uncorrelated with one another, and are both variably overpredicted by up to a factor of {approx}2. Stratiform area fractions are strongly anticorrelated with outgoing longwave radiation (OLR) but are negligibly correlated with ice water path (IWP), indicating that ice spatial distribution controls OLR more than mean IWP. Overpredictions of OLR tend to be accompanied by underpredictions of reflected shortwave radiation (RSR). When there are two simulations differing only in microphysics scheme or large-scale forcing, the one with smaller stratiform area tends to exhibit greater OLR and lesser RSR by similar amounts. After {approx}10 days, simulations reach a suppressed monsoon period with a wide range of mean precipitable water vapor, attributable in part to varying overprediction of cloud-modulated radiative flux divergence compared with observationally derived values. Differences across the simulation ensemble arise from multiple sources, including dynamics, microphysics, and radiation treatments. Close agreement of spatial and temporal averages with observations may not be expected, but the wide spreads of predicted stratiform fraction and anticorrelated OLR indicate a need for more rigorous observation-based evaluation of the underlying micro- and macrophysical properties of convective and stratiform structures.

  6. The impact of air traffic in the NAFC. Model results and measurements

    Energy Technology Data Exchange (ETDEWEB)

    Wauben, W.M.F.; Velthoven, P.F.J. van; Kelder, H.M. [Koninklijk Nederlands Meteorologisch Inst., De Bilt (Netherlands)

    1997-12-31

    The impact of aircraft emissions on the atmospheric composition has been investigated with a global chemistry transport model. The model calculations show that aircraft emissions of nitrogen oxides contribute to about 40-80% of the background values of nitrogen oxides in the North Atlantic Flight Corridor (NAFC), and lead to an increase of the background ozone concentrations by about 3-4% in winter and 5-7% in summer. The three-dimensional distributions of ozone, nitrogen oxides and nitric acid, calculated by using analysed meteorological data, have been compared with airborne measurements performed in the North Atlantic Flight Corridor as part of the EC POLINAT project. The agreement between modelled results and observations is reasonably good for ozone, but worse for nitrogen oxides and nitric acid. (author) 12 refs.

  7. Models of adopting the convicted to the imprisonment conditions – the results of my own research

    Directory of Open Access Journals (Sweden)

    Dorota Kanarek-Lizik

    2013-06-01

    Full Text Available Convicted who are sent to penitentiary, units in order to serve a sentence of imprisonment, are obliged to choose a proper technique (model of coping with the imprisonment discomfort and the way of minimizing discrepancy between the restricted and the outer world at the same time. In order to know these techniques, there has been a special questionnaire written which applies to a model of adopting the convicted to the imprisonment conditions. This questionnaire is based on the types of adaptations enumerated by E. Goffman and these are withdrawal, rebellion, settling down, cold calculation and conversion. In this article I introduced the results of my own research that concern the models of adopting the convicted to the imprisonment conditions. The survey included recidivists and the adults who serve a sentence of imprisonment for the first time.

  8. ORIGEN2 model and results for the Clinch River Breeder Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Croff, A G; Bjerke, M A

    1982-06-01

    Reactor physics calculations and literature information acquisition have led to the development of a Clinch River Breeder Reactor (CRBR) model for the ORIGEN2 computer code. The model is based on cross sections taken directly from physics codes. Details are presented concerning the physical description of the fuel assemblies, the fuel management scheme, irradiation parameters, and initial material compositions. The ORIGEN2 model for the CRBR has been implemented, resulting in the production of graphical and tabular characteristics (radioactivity, thermal power, and toxicity) of CRBR spent fuel, high-level waste, and fuel-assembly structural material waste as a function of decay time. Characteristics for pressurized water reactors (PWRs), commercial liquid-metal fast breeder reactors (LMFBRs), and the Fast Flux Test Facility (FFTF) have also been included in this report for comparison with the CRBR data.

  9. Computer Model of the Empirical Knowledge of Physics Formation: Coordination with Testing Results

    Directory of Open Access Journals (Sweden)

    Robert V. Mayer

    2016-06-01

    Full Text Available The use of method of imitational modeling to study forming the empirical knowledge in pupil’s consciousness is discussed. The offered model is based on division of the physical facts into three categories: 1 the facts established in everyday life; 2 the facts, which the pupil can experimentally establish at a physics lesson; 3 the facts which are studied only on the theoretical level (speculative or ideally. The determination of the forgetting coefficients of the facts of the first, second and third categories and coordination of imitating model with distribution of empirical information in the school physics course and testing results is carried out. The graphs of dependence of empirical knowledge for various physics sections and facts categories on time are given.

  10. Investigations about Starting Cracks in DC-Casting of 6063-Type Billets Part II: Modelling Results

    Science.gov (United States)

    Jensen, E. K.; Schneider, W.

    Influence on starting crack tendency of varying a number of casting parameters has been studied by experiments, Part I (1), and by model calculations, Part II. Both studies point to starting block shape as a most important single factor in controlling starting cracks. By using the thermal model ALSIM-2 in analysing initial experimental results, the variable heat transfer towards the starting block was determined. This made possible a satisfactory model analysis of the starting phase and likewise the formulation of a useful cracking concept. Thus by using calculated and measured liquid pool depth curve in the starting phase of casting as a basis, an effective starting block shape was found. This new shape practically eliminates the starting crack problems in extrusion billets of the AA6063 type alloys.

  11. Role of numerical scheme choice on the results of mathematical modeling of combustion and detonation

    Science.gov (United States)

    Yakovenko, I. S.; Kiverin, A. D.; Pinevich, S. G.; Ivanov, M. F.

    2016-11-01

    The present study discusses capabilities of dissipation-free CABARET numerical method application to unsteady reactive gasdynamic flows modeling. In framework of present research the method was adopted for reactive flows governed by real gas equation of state and applied for several typical problems of unsteady gas dynamics and combustion modeling such as ignition and detonation initiation by localized energy sources. Solutions were thoroughly analyzed and compared with that derived by using of the modified Euler-Lagrange method of “coarse” particles. Obtained results allowed us to distinguish range of phenomena where artificial effects of numerical approach may counterfeit their physical nature and to develop guidelines for numerical approach selection appropriate for unsteady reactive gasdynamic flows numerical modeling.

  12. Understanding the subsurface thermal structure of deep sedimentary basins in Denmark - measurements and modelling results

    DEFF Research Database (Denmark)

    Balling, N.; Poulsen, Søren Erbs; Bording, Thue Sylvester

    2015-01-01

    equilibrium temperature logging has been carried out in a number of accessible deep boreholes. A regional distribution of subsurface temperatures is obtained by combining measurements and 3D numerical modelling in which the heat equation is solved. Modelling results are constrained by observations in terms....... Information of subsurface temperature distribution originates from direct measurements in boreholes and from indirect theoretical modelling. "Point observations" of varying quality are available as industrially measured "Bottom Hole Temperatures" from deep exploration boreholes and accurate continuous...... of available measured temperatures and observed surface heat flow. Information on subsurface thermal conductivity, which is a critical parameter, is obtained from core measurements and well-log analyses. Interval temperature gradients are found to vary by a factor of three to four across lithologies...

  13. Evaluation of observation-fused regional air quality model results for population air pollution exposure estimation.

    Science.gov (United States)

    Chen, Gang; Li, Jingyi; Ying, Qi; Sherman, Seth; Perkins, Neil; Rajeshwari, Sundaram; Mendola, Pauline

    2014-07-01

    In this study, Community Multiscale Air Quality (CMAQ) model was applied to predict ambient gaseous and particulate concentrations during 2001 to 2010 in 15 hospital referral regions (HRRs) using a 36-km horizontal resolution domain. An inverse distance weighting based method was applied to produce exposure estimates based on observation-fused regional pollutant concentration fields using the differences between observations and predictions at grid cells where air quality monitors were located. Although the raw CMAQ model is capable of producing satisfying results for O3 and PM2.5 based on EPA guidelines, using the observation data fusing technique to correct CMAQ predictions leads to significant improvement of model performance for all gaseous and particulate pollutants. Regional average concentrations were calculated using five different methods: 1) inverse distance weighting of observation data alone, 2) raw CMAQ results, 3) observation-fused CMAQ results, 4) population-averaged raw CMAQ results and 5) population-averaged fused CMAQ results. It shows that while O3 (as well as NOx) monitoring networks in the HRRs are dense enough to provide consistent regional average exposure estimation based on monitoring data alone, PM2.5 observation sites (as well as monitors for CO, SO2, PM10 and PM2.5 components) are usually sparse and the difference between the average concentrations estimated by the inverse distance interpolated observations, raw CMAQ and fused CMAQ results can be significantly different. Population-weighted average should be used to account for spatial variation in pollutant concentration and population density. Using raw CMAQ results or observations alone might lead to significant biases in health outcome analyses.

  14. Evaluation of Observation-Fused Regional Air Quality Model Results for Population Air Pollution Exposure Estimation

    Science.gov (United States)

    Chen, Gang; Li, Jingyi; Ying, Qi; Sherman, Seth; Perkins, Neil; Rajeshwari, Sundaram; Mendola, Pauline

    2014-01-01

    In this study, Community Multiscale Air Quality (CMAQ) model was applied to predict ambient gaseous and particulate concentrations during 2001 to 2010 in 15 hospital referral regions (HRRs) using a 36-km horizontal resolution domain. An inverse distance weighting based method was applied to produce exposure estimates based on observation-fused regional pollutant concentration fields using the differences between observations and predictions at grid cells where air quality monitors were located. Although the raw CMAQ model is capable of producing satisfying results for O3 and PM2.5 based on EPA guidelines, using the observation data fusing technique to correct CMAQ predictions leads to significant improvement of model performance for all gaseous and particulate pollutants. Regional average concentrations were calculated using five different methods: 1) inverse distance weighting of observation data alone, 2) raw CMAQ results, 3) observation-fused CMAQ results, 4) population-averaged raw CMAQ results and 5) population-averaged fused CMAQ results. It shows that while O3 (as well as NOx) monitoring networks in the HRR regions are dense enough to provide consistent regional average exposure estimation based on monitoring data alone, PM2.5 observation sites (as well as monitors for CO, SO2, PM10 and PM2.5 components) are usually sparse and the difference between the average concentrations estimated by the inverse distance interpolated observations, raw CMAQ and fused CMAQ results can be significantly different. Population-weighted average should be used to account spatial variation in pollutant concentration and population density. Using raw CMAQ results or observations alone might lead to significant biases in health outcome analyses. PMID:24747248

  15. Sea ice thermohaline dynamics and biogeochemistry in the Arctic Ocean: Empirical and model results

    Science.gov (United States)

    Duarte, Pedro; Meyer, Amelie; Olsen, Lasse M.; Kauko, Hanna M.; Assmy, Philipp; Rösel, Anja; Itkin, Polona; Hudson, Stephen R.; Granskog, Mats A.; Gerland, Sebastian; Sundfjord, Arild; Steen, Harald; Hop, Haakon; Cohen, Lana; Peterson, Algot K.; Jeffery, Nicole; Elliott, Scott M.; Hunke, Elizabeth C.; Turner, Adrian K.

    2017-07-01

    Large changes in the sea ice regime of the Arctic Ocean have occurred over the last decades justifying the development of models to forecast sea ice physics and biogeochemistry. The main goal of this study is to evaluate the performance of the Los Alamos Sea Ice Model (CICE) to simulate physical and biogeochemical properties at time scales of a few weeks and to use the model to analyze ice algal bloom dynamics in different types of ice. Ocean and atmospheric forcing data and observations of the evolution of the sea ice properties collected from 18 April to 4 June 2015, during the Norwegian young sea ICE expedition, were used to test the CICE model. Our results show the following: (i) model performance is reasonable for sea ice thickness and bulk salinity; good for vertically resolved temperature, vertically averaged Chl a concentrations, and standing stocks; and poor for vertically resolved Chl a concentrations. (ii) Improving current knowledge about nutrient exchanges, ice algal recruitment, and motion is critical to improve sea ice biogeochemical modeling. (iii) Ice algae may bloom despite some degree of basal melting. (iv) Ice algal motility driven by gradients in limiting factors is a plausible mechanism to explain their vertical distribution. (v) Different ice algal bloom and net primary production (NPP) patterns were identified in the ice types studied, suggesting that ice algal maximal growth rates will increase, while sea ice vertically integrated NPP and biomass will decrease as a result of the predictable increase in the area covered by refrozen leads in the Arctic Ocean.

  16. Latest results from the EU project AVATAR: Aerodynamic modelling of 10 MW wind turbines

    Science.gov (United States)

    Ceyhan, J. G. Schepers O.; Boorsma, K.; Gonzalez, A.; Munduate, X.; Pires, O.; Sørensen, N..; Ferreira, C.; Sieros, G.; Madsen, J.; Voutsinas, S.; Lutz, T.; Barakos, G.; Colonia, S.; Heißelmann, H.; Meng, F.; Croce, A.

    2016-09-01

    This paper presents the most recent results from the EU project AVATAR in which aerodynamic models are improved and validated for wind turbines on a scale of 10 MW and more. Measurements on a DU 00-W-212 airfoil are presented which have been taken in the pressurized DNW-HDG wind tunnel up to a Reynolds number of 15 Million. These measurements are compared with measurements in the LM wind tunnel for Reynolds numbers of 3 and 6 Million and with calculational results. In the analysis of results special attention is paid to high Reynolds numbers effects. CFD calculations on airfoil performance showed an unexpected large scatter which eventually was reduced by paying even more attention to grid independency and domain size in relation to grid topology. Moreover calculations are presented on flow devices (leading and trailing edge flaps and vortex generators). Finally results are shown between results from 3D rotor models where a comparison is made between results from vortex wake methods and BEM methods at yawed conditions.

  17. Exhibition of Stochastic Resonance in Vestibular Perception

    Science.gov (United States)

    Galvan-Garza, R. C.; Clark, T. K.; Merfeld, D. M.; Bloomberg, J. J.; Oman, C. M.; Mulavara, A. P.

    2016-01-01

    (OTO) with SVS up to 700 µA. A sinusoidal galvanic vestibular stimulation (GVS) perceptual threshold was also measured on each test day and used to normalize the SVS levels across subjects. In roll-tilt thresholds with SVS, the characteristic SR curve was qualitatively exhibited in 10 of 12 subjects, and the improvement in motion threshold was significant in 6 subjects, indicating that optimal SVS improved passive body motion perception in a way that is consistent with classical SR theory. A probabilistic comparison to numeric simulations further validated these experimental results. On the second test session, 4 out of the 10 SR exhibitors showed repeated improvement with SVS compared to the no SVS condition. Data collection is ongoing for the last two test sessions in which SCC and OTO only perceptual motion recognition thresholds are being measured with SVS. The final results of these test sessions will give insight into whether vestibular perceptual SR can occur when only one type of vestibular sensor is sensing motion or if it is more evident when sensory integration between the SCC and OTO is occurring during the motion. The overall purpose of this research is to further quantify the effects of SVS on various sensorimotor tasks and to gain a more fundamental understanding of how SVS causes SR in the vestibular system. In the context of human space flight, results from this research will help in understanding how SVS may be practically implemented in the future as a component of a comprehensive countermeasure plan for G-transition adaptation.

  18. Cosmological model dependence of the galaxy luminosity function: far-infrared results in the Lemaitre-Tolman-Bondi model

    CERN Document Server

    Iribarrem, A; Gruppioni, C; February, S; Ribeiro, M B; Berta, S; Floc'h, E Le; Magnelli, B; Nordon, R; Popesso, P; Pozzi, F; Riguccini, L

    2013-01-01

    This is the first paper of a series aiming at investigating galaxy formation and evolution in the giant-void class of the Lemaitre-Tolman-Bondi (LTB) models that best fits current cosmological observations. Here we investigate the Luminosity Function (LF) methodology, and how its estimates would be affected by a change on the cosmological model assumed in its computation. Are the current observational constraints on the allowed Cosmology enough to yield robust LF results? We use the far-infrared source catalogues built on the observations performed with the Herschel/PACS instrument, and selected as part of the PACS evolutionary probe (PEP) survey. Schechter profiles are obtained in redshift bins up to z approximately 4, assuming comoving volumes in both the standard model, that is, Friedmann-Lemaitre-Robertson-Walker metric with a perfect fluid energy-momentum tensor, and non-homogeneous LTB dust models, parametrized to fit the current combination of results stemming from the observations of supernovae Ia, th...

  19. A Two-Moment Bulk Microphysics Coupled with a Mesoscale Model WRF: Model Description and First Results

    Institute of Scientific and Technical Information of China (English)

    GAO Wenhua; ZHAO Fengsheng; HU Zhijin; FENG Xua

    2011-01-01

    The Chinese Academy of Meteorological Sciences (CAMS) two-moment bulk microphysics scheme was adopted in this study to investigate the representation of cloud and precipitation processes under different environmental conditions.The scheme predicts the mixing ratio of water vapor as well as the mixing ratios and nnmber concentrations of cloud droplets,rain,ice,snow,and graupel.A new parameterization approach to simulate heterogeneous droplet activation was developed in this scheme.Furthermore,the improved CAMS scheme was coupled with the Weather Research and Forecasting model (WRF v3.1),which made it possible to simulate the microphysics of clouds and precipitation as well as the cloud-aerosol interactions in selected atmospheric condition.The rain event occurring on 27 28 December 2008 in eastern China was simulated using the CAMS scheme and three sophisticated microphysics schemes in the WRF model.Results showed that the simulated 36-h accumulated precipitations were generally agreed with observation data,and the CAMS scheme performed well in the southern area of the nested donain.The radar reflectivity,the averaged precipitation intensity,and the hydrometeor mixing ratios simulated by the CAMS scheme were generally consistent with those from other microphysics schemes.The hydrometeor number concentrations simulated by the CAMS scheme were also close to the experiential values in stratus clouds.The model results suggest that the CAMS scheme performs reasonably well in describing the microphysics of clouds and precipitation in the mesoscale WRF model.

  20. Comparison of Global Model Results from the Carbon-Land Model Intercomparison Project (C-LAMP) with Free-Air Carbon Dioxide Enrichment (FACE) Manipulation Experiments

    Science.gov (United States)

    Hoffman, F. M.; Randerson, J. T.; Fung, I.; Thornton, P.; Covey, C.; Bonan, G.; Running, S.; Norby, R.

    2008-12-01

    Free-Air CO2 Enrichment (FACE) manipulation experiments have been carried out at a handful of sites to gauge the response of the biosphere to significant increases in atmospheric [CO2]. Early synthesis results from four temperate forest sites suggest that the response of net primary productivity (NPP) is conserved across a broad range of productivity with a stimulation at the median of 23±2% when the surrounding air [CO2] was raised to 550~ppm. As a part of the Carbon-Land Model Intercomparison Project (C-LAMP), a community-based model-data comparison activity, the authors have performed a global FACE modeling experiment using two terrestrial biogeochemistry modules, CLM3-CASA' and CLM3-CN, coupled to the National Center for Atmospheric Research (NCAR) Community Climate System Model (CCSM). The two models were forced with an improved NCEP/NCAR reanalysis data set and reconstructed atmospheric [CO2] and N deposition data through 1997. At the beginning of 1997 in the transient simulations, global atmospheric [CO2] was abruptly raised to 550~ppm, the target value used at the FACE sites. In the control runs, [CO2] continued to rise following observations until 2004, after which it was held constant out to year 2100. In both simulations, the last 25 years of reanalysis forcing and a constant N deposition were applied after year 2004. Across all forest biomes, the NPP responses from both models are weaker than those reported for the four FACE sites. Moreover, model responses vary widely geographically with a decreasing trend of NPP increases from 40°N to 70°N. For CLM3- CASA', the largest responses occur in arid regions of western North America and central Asia, suggesting that responses are most strongly influenced by increased water use efficiency for this model. CLM3-CN exhibits consistently weaker responses than CLM3-CASA' with the strongest responses in central Asia, but significantly constrained by N limitation. C-LAMP is a sub-project of the Computational