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  1. Ordinal models of audiovisual speech perception

    DEFF Research Database (Denmark)

    Andersen, Tobias

    2011-01-01

    Audiovisual information is integrated in speech perception. One manifestation of this is the McGurk illusion in which watching the articulating face alters the auditory phonetic percept. Understanding this phenomenon fully requires a computational model with predictive power. Here, we describe...... ordinal models that can account for the McGurk illusion. We compare this type of models to the Fuzzy Logical Model of Perception (FLMP) in which the response categories are not ordered. While the FLMP generally fit the data better than the ordinal model it also employs more free parameters in complex...... experiments when the number of response categories are high as it is for speech perception in general. Testing the predictive power of the models using a form of cross-validation we found that ordinal models perform better than the FLMP. Based on these findings we suggest that ordinal models generally have...

  2. Model county ordinance for wind projects

    Energy Technology Data Exchange (ETDEWEB)

    Bain, D.A. [Oregon Office of Energy, Portland, OR (United States)

    1997-12-31

    Permitting is a crucial step in the development cycle of a wind project and permits affect the timing, cost, location, feasibility, layout, and impacts of wind projects. Counties often have the lead responsibility for permitting yet few have appropriate siting regulations for wind projects. A model ordinance allows a county to quickly adopt appropriate permitting procedures. The model county wind ordinance developed for use by northwest states is generally applicable across the country and counties seeking to adopt siting or zoning regulations for wind will find it a good starting place. The model includes permitting procedures for wind measurement devices and two types of wind systems. Both discretionary and nondiscretionary standards apply to wind systems and a conditional use permit would be issued. The standards, criteria, conditions for approval, and process procedures are defined for each. Adaptation examples for the four northwest states are provided along with a model Wind Resource Overlay Zone.

  3. An ordinal model of the McGurk illusion

    DEFF Research Database (Denmark)

    Andersen, Tobias

    2011-01-01

    an ordinal model, in which the response categories are ordered cyclically, that can account for the McGurk illusion. We compare this model to the Fuzzy Logical Model of Perception (FLMP), which is not an ordinal model, based on an original data set. While the FLMP fitted the data better than the ordinal...

  4. An ordinal model of the McGurk illusion

    DEFF Research Database (Denmark)

    Andersen, Tobias

    2011-01-01

    Audiovisual information is integrated in speech perception. One manifestation of this is the McGurk illusion in which watching the articulating face alters the auditory phonetic percept. Understanding this phenomenon fully requires a computational model with predictive power. Here, we describe...... model it also employed 30 free parameters where the ordinal model needed only 14. Testing the predictive power of the models using a form of cross-validation we found that, although both models performed rather poorly, the ordinal model performed better than the FLMP. Based on these findings we suggest...

  5. Parameters Estimation of Geographically Weighted Ordinal Logistic Regression (GWOLR) Model

    Science.gov (United States)

    Zuhdi, Shaifudin; Retno Sari Saputro, Dewi; Widyaningsih, Purnami

    2017-06-01

    A regression model is the representation of relationship between independent variable and dependent variable. The dependent variable has categories used in the logistic regression model to calculate odds on. The logistic regression model for dependent variable has levels in the logistics regression model is ordinal. GWOLR model is an ordinal logistic regression model influenced the geographical location of the observation site. Parameters estimation in the model needed to determine the value of a population based on sample. The purpose of this research is to parameters estimation of GWOLR model using R software. Parameter estimation uses the data amount of dengue fever patients in Semarang City. Observation units used are 144 villages in Semarang City. The results of research get GWOLR model locally for each village and to know probability of number dengue fever patient categories.

  6. Modeling and evaluating repeatability and reproducibility of ordinal classifications

    NARCIS (Netherlands)

    J. de Mast; W.N. van Wieringen

    2010-01-01

    This paper argues that currently available methods for the assessment of the repeatability and reproducibility of ordinal classifications are not satisfactory. The paper aims to study whether we can modify a class of models from Item Response Theory, well established for the study of the reliability

  7. A hierarchical model for ordinal matrix factorization

    DEFF Research Database (Denmark)

    Paquet, Ulrich; Thomson, Blaise; Winther, Ole

    2012-01-01

    their ratings for other movies. The Netflix data set is used for evaluation, which consists of around 100 million ratings. Using root mean-squared error (RMSE) as an evaluation metric, results show that the suggested model outperforms alternative factorization techniques. Results also show how Gibbs sampling...

  8. Comparing interval estimates for small sample ordinal CFA models.

    Science.gov (United States)

    Natesan, Prathiba

    2015-01-01

    Robust maximum likelihood (RML) and asymptotically generalized least squares (AGLS) methods have been recommended for fitting ordinal structural equation models. Studies show that some of these methods underestimate standard errors. However, these studies have not investigated the coverage and bias of interval estimates. An estimate with a reasonable standard error could still be severely biased. This can only be known by systematically investigating the interval estimates. The present study compares Bayesian, RML, and AGLS interval estimates of factor correlations in ordinal confirmatory factor analysis models (CFA) for small sample data. Six sample sizes, 3 factor correlations, and 2 factor score distributions (multivariate normal and multivariate mildly skewed) were studied. Two Bayesian prior specifications, informative and relatively less informative were studied. Undercoverage of confidence intervals and underestimation of standard errors was common in non-Bayesian methods. Underestimated standard errors may lead to inflated Type-I error rates. Non-Bayesian intervals were more positive biased than negatively biased, that is, most intervals that did not contain the true value were greater than the true value. Some non-Bayesian methods had non-converging and inadmissible solutions for small samples and non-normal data. Bayesian empirical standard error estimates for informative and relatively less informative priors were closer to the average standard errors of the estimates. The coverage of Bayesian credibility intervals was closer to what was expected with overcoverage in a few cases. Although some Bayesian credibility intervals were wider, they reflected the nature of statistical uncertainty that comes with the data (e.g., small sample). Bayesian point estimates were also more accurate than non-Bayesian estimates. The results illustrate the importance of analyzing coverage and bias of interval estimates, and how ignoring interval estimates can be misleading

  9. Fitting Multilevel Models with Ordinal Outcomes: Performance of Alternative Specifications and Methods of Estimation

    Science.gov (United States)

    Bauer, Daniel J.; Sterba, Sonya K.

    2011-01-01

    Previous research has compared methods of estimation for fitting multilevel models to binary data, but there are reasons to believe that the results will not always generalize to the ordinal case. This article thus evaluates (a) whether and when fitting multilevel linear models to ordinal outcome data is justified and (b) which estimator to employ…

  10. Sufficient Sample Size and Power in Multilevel Ordinal Logistic Regression Models

    Directory of Open Access Journals (Sweden)

    Sabz Ali

    2016-01-01

    Full Text Available For most of the time, biomedical researchers have been dealing with ordinal outcome variable in multilevel models where patients are nested in doctors. We can justifiably apply multilevel cumulative logit model, where the outcome variable represents the mild, severe, and extremely severe intensity of diseases like malaria and typhoid in the form of ordered categories. Based on our simulation conditions, Maximum Likelihood (ML method is better than Penalized Quasilikelihood (PQL method in three-category ordinal outcome variable. PQL method, however, performs equally well as ML method where five-category ordinal outcome variable is used. Further, to achieve power more than 0.80, at least 50 groups are required for both ML and PQL methods of estimation. It may be pointed out that, for five-category ordinal response variable model, the power of PQL method is slightly higher than the power of ML method.

  11. Sufficient Sample Size and Power in Multilevel Ordinal Logistic Regression Models

    Science.gov (United States)

    Ali, Amjad; Khan, Sajjad Ahmad; Hussain, Sundas

    2016-01-01

    For most of the time, biomedical researchers have been dealing with ordinal outcome variable in multilevel models where patients are nested in doctors. We can justifiably apply multilevel cumulative logit model, where the outcome variable represents the mild, severe, and extremely severe intensity of diseases like malaria and typhoid in the form of ordered categories. Based on our simulation conditions, Maximum Likelihood (ML) method is better than Penalized Quasilikelihood (PQL) method in three-category ordinal outcome variable. PQL method, however, performs equally well as ML method where five-category ordinal outcome variable is used. Further, to achieve power more than 0.80, at least 50 groups are required for both ML and PQL methods of estimation. It may be pointed out that, for five-category ordinal response variable model, the power of PQL method is slightly higher than the power of ML method.

  12. Bayesian inference for joint modelling of longitudinal continuous, binary and ordinal events.

    Science.gov (United States)

    Li, Qiuju; Pan, Jianxin; Belcher, John

    2016-12-01

    In medical studies, repeated measurements of continuous, binary and ordinal outcomes are routinely collected from the same patient. Instead of modelling each outcome separately, in this study we propose to jointly model the trivariate longitudinal responses, so as to take account of the inherent association between the different outcomes and thus improve statistical inferences. This work is motivated by a large cohort study in the North West of England, involving trivariate responses from each patient: Body Mass Index, Depression (Yes/No) ascertained with cut-off score not less than 8 at the Hospital Anxiety and Depression Scale, and Pain Interference generated from the Medical Outcomes Study 36-item short-form health survey with values returned on an ordinal scale 1-5. There are some well-established methods for combined continuous and binary, or even continuous and ordinal responses, but little work was done on the joint analysis of continuous, binary and ordinal responses. We propose conditional joint random-effects models, which take into account the inherent association between the continuous, binary and ordinal outcomes. Bayesian analysis methods are used to make statistical inferences. Simulation studies show that, by jointly modelling the trivariate outcomes, standard deviations of the estimates of parameters in the models are smaller and much more stable, leading to more efficient parameter estimates and reliable statistical inferences. In the real data analysis, the proposed joint analysis yields a much smaller deviance information criterion value than the separate analysis, and shows other good statistical properties too.

  13. Fitting Proportional Odds Models to Educational Data in Ordinal Logistic Regression Using Stata, SAS and SPSS

    Science.gov (United States)

    Liu, Xing

    2008-01-01

    The proportional odds (PO) model, which is also called cumulative odds model (Agresti, 1996, 2002 ; Armstrong & Sloan, 1989; Long, 1997, Long & Freese, 2006; McCullagh, 1980; McCullagh & Nelder, 1989; Powers & Xie, 2000; O'Connell, 2006), is one of the most commonly used models for the analysis of ordinal categorical data and comes from the class…

  14. Ordinal regression models to describe tourist satisfaction with Sintra's world heritage

    Science.gov (United States)

    Mouriño, Helena

    2013-10-01

    In Tourism Research, ordinal regression models are becoming a very powerful tool in modelling the relationship between an ordinal response variable and a set of explanatory variables. In August and September 2010, we conducted a pioneering Tourist Survey in Sintra, Portugal. The data were obtained by face-to-face interviews at the entrances of the Palaces and Parks of Sintra. The work developed in this paper focus on two main points: tourists' perception of the entrance fees; overall level of satisfaction with this heritage site. For attaining these goals, ordinal regression models were developed. We concluded that tourist's nationality was the only significant variable to describe the perception of the admission fees. Also, Sintra's image among tourists depends not only on their nationality, but also on previous knowledge about Sintra's World Heritage status.

  15. Finite Mixture Multilevel Multidimensional Ordinal IRT Models for Large Scale Cross-Cultural Research

    NARCIS (Netherlands)

    M.G. de Jong (Martijn); J-B.E.M. Steenkamp (Jan-Benedict)

    2009-01-01

    textabstractWe present a class of finite mixture multilevel multidimensional ordinal IRT models for large scale cross-cultural research. Our model is proposed for confirmatory research settings. Our prior for item parameters is a mixture distribution to accommodate situations where different groups

  16. A Composite Likelihood Inference in Latent Variable Models for Ordinal Longitudinal Responses

    Science.gov (United States)

    Vasdekis, Vassilis G. S.; Cagnone, Silvia; Moustaki, Irini

    2012-01-01

    The paper proposes a composite likelihood estimation approach that uses bivariate instead of multivariate marginal probabilities for ordinal longitudinal responses using a latent variable model. The model considers time-dependent latent variables and item-specific random effects to be accountable for the interdependencies of the multivariate…

  17. A Composite Likelihood Inference in Latent Variable Models for Ordinal Longitudinal Responses

    Science.gov (United States)

    Vasdekis, Vassilis G. S.; Cagnone, Silvia; Moustaki, Irini

    2012-01-01

    The paper proposes a composite likelihood estimation approach that uses bivariate instead of multivariate marginal probabilities for ordinal longitudinal responses using a latent variable model. The model considers time-dependent latent variables and item-specific random effects to be accountable for the interdependencies of the multivariate…

  18. Temperature Modelling of the Biomass Pretreatment Process

    DEFF Research Database (Denmark)

    2012-01-01

    In a second generation biorefinery, the biomass pretreatment stage has an important contribution to the efficiency of the downstream processing units involved in biofuel production. Most of the pretreatment process occurs in a large pressurized thermal reactor that presents an irregular temperature...... distribution. Therefore, an accurate temperature model is critical for observing the biomass pretreatment. More than that, the biomass is also pushed with a constant horizontal speed along the reactor in order to ensure a continuous throughput. The goal of this paper is to derive a temperature model...

  19. Modeling thermal sensation in a Mediterranean climate—a comparison of linear and ordinal models

    Science.gov (United States)

    Pantavou, Katerina; Lykoudis, Spyridon

    2014-08-01

    A simple thermo-physiological model of outdoor thermal sensation adjusted with psychological factors is developed aiming to predict thermal sensation in Mediterranean climates. Microclimatic measurements simultaneously with interviews on personal and psychological conditions were carried out in a square, a street canyon and a coastal location of the greater urban area of Athens, Greece. Multiple linear and ordinal regression were applied in order to estimate thermal sensation making allowance for all the recorded parameters or specific, empirically selected, subsets producing so-called extensive and empirical models, respectively. Meteorological, thermo-physiological and overall models - considering psychological factors as well - were developed. Predictions were improved when personal and psychological factors were taken into account as compared to meteorological models. The model based on ordinal regression reproduced extreme values of thermal sensation vote more adequately than the linear regression one, while the empirical model produced satisfactory results in relation to the extensive model. The effects of adaptation and expectation on thermal sensation vote were introduced in the models by means of the exposure time, season and preference related to air temperature and irradiation. The assessment of thermal sensation could be a useful criterion in decision making regarding public health, outdoor spaces planning and tourism.

  20. A New Statistic for Evaluating Item Response Theory Models for Ordinal Data. CRESST Report 839

    Science.gov (United States)

    Cai, Li; Monroe, Scott

    2014-01-01

    We propose a new limited-information goodness of fit test statistic C[subscript 2] for ordinal IRT models. The construction of the new statistic lies formally between the M[subscript 2] statistic of Maydeu-Olivares and Joe (2006), which utilizes first and second order marginal probabilities, and the M*[subscript 2] statistic of Cai and Hansen…

  1. A comparison of ordinal regression models in an analysis of factors associated with periodontal disease

    Directory of Open Access Journals (Sweden)

    Javali Shivalingappa

    2010-01-01

    Full Text Available Aim: The study aimed to determine the factors associated with periodontal disease (different levels of severity by using different regression models for ordinal data. Design: A cross-sectional design was employed using clinical examination and ′questionnaire with interview′ method. Materials and Methods: The study was conducted during June 2008 to October 2008 in Dharwad, Karnataka, India. It involved a systematic random sample of 1760 individuals aged 18-40 years. The periodontal disease examination was conducted by using Community Periodontal Index for Treatment Needs (CPITN. Statistical Analysis Used: Regression models for ordinal data with different built-in link functions were used in determination of factors associated with periodontal disease. Results: The study findings indicated that, the ordinal regression models with four built-in link functions (logit, probit, Clog-log and nlog-log displayed similar results with negligible differences in significant factors associated with periodontal disease. The factors such as religion, caste, sources of drinking water, Timings for sweet consumption, Timings for cleaning or brushing the teeth and materials used for brushing teeth were significantly associated with periodontal disease in all ordinal models. Conclusions: The ordinal regression model with Clog-log is a better fit in determination of significant factors associated with periodontal disease as compared to models with logit, probit and nlog-log built-in link functions. The factors such as caste and time for sweet consumption are negatively associated with periodontal disease. But religion, sources of drinking water, Timings for cleaning or brushing the teeth and materials used for brushing teeth are significantly and positively associated with periodontal disease.

  2. A comparison of ordinal regression models in an analysis of factors associated with periodontal disease

    OpenAIRE

    Javali Shivalingappa; Pandit Parameshwar

    2010-01-01

    Aim: The study aimed to determine the factors associated with periodontal disease (different levels of severity) by using different regression models for ordinal data. Design: A cross-sectional design was employed using clinical examination and ′questionnaire with interview′ method. Materials and Methods: The study was conducted during June 2008 to October 2008 in Dharwad, Karnataka, India. It involved a systematic random sample of 1760 individuals aged 18-40 years. The periodon...

  3. Assessing Heterogeneity for Factor Analysis Model with Continuous and Ordinal Outcomes

    Directory of Open Access Journals (Sweden)

    Ye-Mao Xia

    2016-01-01

    Full Text Available Factor analysis models with continuous and ordinal responses are a useful tool for assessing relations between the latent variables and mixed observed responses. These models have been successfully applied to many different fields, including behavioral, educational, and social-psychological sciences. However, within the Bayesian analysis framework, most developments are constrained within parametric families, of which the particular distributions are specified for the parameters of interest. This leads to difficulty in dealing with outliers and/or distribution deviations. In this paper, we propose a Bayesian semiparametric modeling for factor analysis model with continuous and ordinal variables. A truncated stick-breaking prior is used to model the distributions of the intercept and/or covariance structural parameters. Bayesian posterior analysis is carried out through the simulation-based method. Blocked Gibbs sampler is implemented to draw observations from the complicated posterior. For model selection, the logarithm of pseudomarginal likelihood is developed to compare the competing models. Empirical results are presented to illustrate the application of the methodology.

  4. Autoregressive transitional ordinal model to test for treatment effect in neurological trials with complex endpoints

    Directory of Open Access Journals (Sweden)

    Lorenzo G. Tanadini

    2016-11-01

    Full Text Available Abstract Background A number of potential therapeutic approaches for neurological disorders have failed to provide convincing evidence of efficacy, prompting pharmaceutical and health companies to discontinue their involvement in drug development. Limitations in the statistical analysis of complex endpoints have very likely had a negative impact on the translational process. Methods We propose a transitional ordinal model with an autoregressive component to overcome previous limitations in the analysis of Upper Extremity Motor Scores, a relevant endpoint in the field of Spinal Cord Injury. Statistical power and clinical interpretation of estimated treatment effects of the proposed model were compared to routinely employed approaches in a large simulation study of two-arm randomized clinical trials. A revisitation of a key historical trial provides further comparison between the different analysis approaches. Results The proposed model outperformed all other approaches in virtually all simulation settings, achieving on average 14 % higher statistical power than the respective second-best performing approach (range: -1 %, +34 %. Only the transitional model allows treatment effect estimates to be interpreted as conditional odds ratios, providing clear interpretation and visualization. Conclusion The proposed model takes into account the complex ordinal nature of the endpoint under investigation and explicitly accounts for relevant prognostic factors such as lesion level and baseline information. Superior statistical power, combined with clear clinical interpretation of estimated treatment effects and widespread availability in commercial software, are strong arguments for clinicians and trial scientists to adopt, and further extend, the proposed approach.

  5. Logistic random effects regression models: a comparison of statistical packages for binary and ordinal outcomes

    Directory of Open Access Journals (Sweden)

    Steyerberg Ewout W

    2011-05-01

    Full Text Available Abstract Background Logistic random effects models are a popular tool to analyze multilevel also called hierarchical data with a binary or ordinal outcome. Here, we aim to compare different statistical software implementations of these models. Methods We used individual patient data from 8509 patients in 231 centers with moderate and severe Traumatic Brain Injury (TBI enrolled in eight Randomized Controlled Trials (RCTs and three observational studies. We fitted logistic random effects regression models with the 5-point Glasgow Outcome Scale (GOS as outcome, both dichotomized as well as ordinal, with center and/or trial as random effects, and as covariates age, motor score, pupil reactivity or trial. We then compared the implementations of frequentist and Bayesian methods to estimate the fixed and random effects. Frequentist approaches included R (lme4, Stata (GLLAMM, SAS (GLIMMIX and NLMIXED, MLwiN ([R]IGLS and MIXOR, Bayesian approaches included WinBUGS, MLwiN (MCMC, R package MCMCglmm and SAS experimental procedure MCMC. Three data sets (the full data set and two sub-datasets were analysed using basically two logistic random effects models with either one random effect for the center or two random effects for center and trial. For the ordinal outcome in the full data set also a proportional odds model with a random center effect was fitted. Results The packages gave similar parameter estimates for both the fixed and random effects and for the binary (and ordinal models for the main study and when based on a relatively large number of level-1 (patient level data compared to the number of level-2 (hospital level data. However, when based on relatively sparse data set, i.e. when the numbers of level-1 and level-2 data units were about the same, the frequentist and Bayesian approaches showed somewhat different results. The software implementations differ considerably in flexibility, computation time, and usability. There are also differences in

  6. A Multinomial Ordinal Probit Model with Singular Value Decomposition Method for a Multinomial Trait

    Directory of Open Access Journals (Sweden)

    Soonil Kwon

    2012-01-01

    Full Text Available We developed a multinomial ordinal probit model with singular value decomposition for testing a large number of single nucleotide polymorphisms (SNPs simultaneously for association with multidisease status when sample size is much smaller than the number of SNPs. The validity and performance of the method was evaluated via simulation. We applied the method to our real study sample recruited through the Mexican-American Coronary Artery Disease study. We found 3 genes (SORCS1, AMPD1, and PPARα to be associated with the development of both IGT and IFG, while 5 genes (AMPD2, PRKAA2, C5, TCF7L2, and ITR with the IGT mechanism only and 6 genes (CAPN10, IL4, NOS3, CD14, GCG, and SORT1 with the IFG mechanism only. These data suggest that IGT and IFG may indicate different physiological mechanism to prediabetes, via different genetic determinants.

  7. Fisher Scoring Method for Parameter Estimation of Geographically Weighted Ordinal Logistic Regression (GWOLR) Model

    Science.gov (United States)

    Widyaningsih, Purnami; Retno Sari Saputro, Dewi; Nugrahani Putri, Aulia

    2017-06-01

    GWOLR model combines geographically weighted regression (GWR) and (ordinal logistic reression) OLR models. Its parameter estimation employs maximum likelihood estimation. Such parameter estimation, however, yields difficult-to-solve system of nonlinear equations, and therefore numerical approximation approach is required. The iterative approximation approach, in general, uses Newton-Raphson (NR) method. The NR method has a disadvantage—its Hessian matrix is always the second derivatives of each iteration so it does not always produce converging results. With regard to this matter, NR model is modified by substituting its Hessian matrix into Fisher information matrix, which is termed Fisher scoring (FS). The present research seeks to determine GWOLR model parameter estimation using Fisher scoring method and apply the estimation on data of the level of vulnerability to Dengue Hemorrhagic Fever (DHF) in Semarang. The research concludes that health facilities give the greatest contribution to the probability of the number of DHF sufferers in both villages. Based on the number of the sufferers, IR category of DHF in both villages can be determined.

  8. Evaluation of reflection and refraction in simulations of ultraviolet disinfection using the discrete ordinates radiation model.

    Science.gov (United States)

    Ho, C K

    2009-01-01

    Simulations of UV disinfection systems require accurate models of UV radiation within the reactor. Processes such as reflection and refraction at surfaces within the reactor can impact the intensity of the simulated radiation field, which in turn impacts the simulated dose and performance of the UV reactor. This paper describes a detailed discrete ordinates radiation model and comparisons to a test that recorded the UV radiation distribution around a low pressure UV lamp in a water-filled chamber with a UV transmittance of 88%. The effects of reflection and refraction at the quartz sleeve were investigated, along with the impact of wall reflection from the interior surfaces of the chamber. Results showed that the inclusion of wall reflection improved matches between predicted and measured values of incident radiation throughout the chamber. The difference between simulations with and without reflection ranged from several percent near the lamp to nearly 40% further away from the lamp. Neglecting reflection and refraction at the quartz sleeve increased the simulated radiation near the lamp and reduced the simulated radiation further away from the lamp. However, the distribution and trends in the simulated radiation field both with and without the effects of reflection and refraction at the quartz sleeve were consistent with the measured data distributions.

  9. Patterns of Dupuytren disease in fingers: studying correlations with a multivariate ordinal logit model.

    Science.gov (United States)

    Lanting, Rosanne; Nooraee, Nazanin; Werker, Paul M N; van den Heuvel, Edwin R

    2014-09-01

    Dupuytren disease affects fingers in a variable fashion. Knowledge about specific disease patterns (phenotype) based on location and severity of the disease is lacking. In this cross-sectional study, 344 primary affected hands with Dupuytren disease were physically examined. The Pearson correlation coefficient between the coexistence of Dupuytren disease in pairs of fingers was calculated, and agglomerative hierarchical clustering was applied to identify possible clusters of affected fingers. With a multivariate ordinal logit model, the authors studied the correlation on severity, taking into account age and sex, and tested hypotheses on independence between groups of fingers. The ring finger was most frequently affected by Dupuytren disease, and contractures were seen in 15.1 percent of affected rays. The severity of thumb and index finger, middle and ring fingers, and middle and little fingers was significantly correlated. Occurrences in pairs of fingers were highest in the middle and ring fingers and lowest in the thumb and index finger. Correlation between the ring and little fingers and a correlation between fingers from the ulnar and radial sides could not be demonstrated. Rays on the ulnar side of the hand are predominantly affected. The middle finger is substantially correlated with other fingers on the ulnar side, and the thumb and index finger are correlated; however, there was no evidence that the ulnar side and the radial side were correlated in any way, which suggests that occurrence on one side of the hand does not predict Dupuytren disease on the other side of the hand. Risk, III.

  10. Global Volcano Model: progress towards an international co-ordinated network for volcanic hazard and risk

    Science.gov (United States)

    Loughlin, Susan

    2013-04-01

    GVM is a growing international collaboration that aims to create a sustainable, accessible information platform on volcanic hazard and risk. GVM is a network that aims to co-ordinate and integrate the efforts of the international volcanology community. Major international initiatives and partners such as the Smithsonian Institution - Global Volcanism Program, State University of New York at Buffalo - VHub, Earth Observatory of Singapore - WOVOdat and many others underpin GVM. Activities currently include: design and development of databases of volcano data, volcanic hazards, vulnerability and exposure with internationally agreed metadata standards; establishment of methodologies for analysis of the data (e.g. hazard and exposure indices) to inform risk assessment; development of complementary hazards models and create relevant hazards and risk assessment tools. GVM acts through establishing task forces to deliver explicit deliverables in finite periods of time. GVM has a task force to deliver a global assessment of volcanic risk for UN ISDR, a task force for indices, and a task force for volcano deformation from satellite observations. GVM is organising a Volcano Best Practices workshop in 2013. A recent product of GVM is a global database on large magnitude explosive eruptions. There is ongoing work to develop databases on debris avalanches, lava dome hazards and ash hazard. GVM aims to develop the capability to anticipate future volcanism and its consequences.

  11. Ordinal Bivariate Inequality

    DEFF Research Database (Denmark)

    Sonne-Schmidt, Christoffer Scavenius; Tarp, Finn; Østerdal, Lars Peter Raahave

    2016-01-01

    This paper introduces a concept of inequality comparisons with ordinal bivariate categorical data. In our model, one population is more unequal than another when they have common arithmetic median outcomes and the first can be obtained from the second by correlation-increasing switches and...

  12. The Theory of Sets of Ordinals

    OpenAIRE

    Koepke, Peter; Koerwien, Martin

    2005-01-01

    We propose a natural theory SO axiomatizing the class of sets of ordinals in a model of ZFC set theory. Both theories possess equal logical strength. Constructibility theory in SO corresponds to a natural recursion theory on ordinals.

  13. Reconsidering the use of rankings in the valuation of health states: a model for estimating cardinal values from ordinal data

    Directory of Open Access Journals (Sweden)

    Salomon Joshua A

    2003-12-01

    Full Text Available Abstract Background In survey studies on health-state valuations, ordinal ranking exercises often are used as precursors to other elicitation methods such as the time trade-off (TTO or standard gamble, but the ranking data have not been used in deriving cardinal valuations. This study reconsiders the role of ordinal ranks in valuing health and introduces a new approach to estimate interval-scaled valuations based on aggregate ranking data. Methods Analyses were undertaken on data from a previously published general population survey study in the United Kingdom that included rankings and TTO values for hypothetical states described using the EQ-5D classification system. The EQ-5D includes five domains (mobility, self-care, usual activities, pain/discomfort and anxiety/depression with three possible levels on each. Rank data were analysed using a random utility model, operationalized through conditional logit regression. In the statistical model, probabilities of observed rankings were related to the latent utilities of different health states, modeled as a linear function of EQ-5D domain scores, as in previously reported EQ-5D valuation functions. Predicted valuations based on the conditional logit model were compared to observed TTO values for the 42 states in the study and to predictions based on a model estimated directly from the TTO values. Models were evaluated using the intraclass correlation coefficient (ICC between predictions and mean observations, and the root mean squared error of predictions at the individual level. Results Agreement between predicted valuations from the rank model and observed TTO values was very high, with an ICC of 0.97, only marginally lower than for predictions based on the model estimated directly from TTO values (ICC = 0.99. Individual-level errors were also comparable in the two models, with root mean squared errors of 0.503 and 0.496 for the rank-based and TTO-based predictions, respectively. Conclusions

  14. Reconsidering the use of rankings in the valuation of health states: a model for estimating cardinal values from ordinal data.

    Science.gov (United States)

    Salomon, Joshua A

    2003-12-19

    BACKGROUND: In survey studies on health-state valuations, ordinal ranking exercises often are used as precursors to other elicitation methods such as the time trade-off (TTO) or standard gamble, but the ranking data have not been used in deriving cardinal valuations. This study reconsiders the role of ordinal ranks in valuing health and introduces a new approach to estimate interval-scaled valuations based on aggregate ranking data. METHODS: Analyses were undertaken on data from a previously published general population survey study in the United Kingdom that included rankings and TTO values for hypothetical states described using the EQ-5D classification system. The EQ-5D includes five domains (mobility, self-care, usual activities, pain/discomfort and anxiety/depression) with three possible levels on each. Rank data were analysed using a random utility model, operationalized through conditional logit regression. In the statistical model, probabilities of observed rankings were related to the latent utilities of different health states, modeled as a linear function of EQ-5D domain scores, as in previously reported EQ-5D valuation functions. Predicted valuations based on the conditional logit model were compared to observed TTO values for the 42 states in the study and to predictions based on a model estimated directly from the TTO values. Models were evaluated using the intraclass correlation coefficient (ICC) between predictions and mean observations, and the root mean squared error of predictions at the individual level. RESULTS: Agreement between predicted valuations from the rank model and observed TTO values was very high, with an ICC of 0.97, only marginally lower than for predictions based on the model estimated directly from TTO values (ICC = 0.99). Individual-level errors were also comparable in the two models, with root mean squared errors of 0.503 and 0.496 for the rank-based and TTO-based predictions, respectively. CONCLUSIONS: Modeling health

  15. ORDINAL REGRESSION FOR INFORMATION RETRIEVAL

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    This letter presents a new discriminative model for Information Retrieval (IR), referred to as Ordinal Regression Model (ORM). ORM is different from most existing models in that it views IR as ordinal regression problem (i.e. ranking problem) instead of binary classification. It is noted that the task of IR is to rank documents according to the user information needed, so IR can be viewed as ordinal regression problem. Two parameter learning algorithms for ORM are presented. One is a perceptron-based algorithm. The other is the ranking Support Vector Machine (SVM). The effectiveness of the proposed approach has been evaluated on the task of ad hoc retrieval using three English Text REtrieval Conference (TREC) sets and two Chinese TREC sets. Results show that ORM significantly outperforms the state-of-the-art language model approaches and OKAPI system in all test sets; and it is more appropriate to view IR as ordinal regression other than binary classification.

  16. Ordinal logistic regression models: application in quality of life studies Modelos de regressão logística ordinal: aplicação em estudo sobre qualidade de vida

    Directory of Open Access Journals (Sweden)

    Mery Natali Silva Abreu

    2008-01-01

    Full Text Available Quality of life has been increasingly emphasized in public health research in recent years. Typically, the results of quality of life are measured by means of ordinal scales. In these situations, specific statistical methods are necessary because procedures such as either dichotomization or misinformation on the distribution of the outcome variable may complicate the inferential process. Ordinal logistic regression models are appropriate in many of these situations. This article presents a review of the proportional odds model, partial proportional odds model, continuation ratio model, and stereotype model. The fit, statistical inference, and comparisons between models are illustrated with data from a study on quality of life in 273 patients with schizophrenia. All tested models showed good fit, but the proportional odds or partial proportional odds models proved to be the best choice due to the nature of the data and ease of interpretation of the results. Ordinal logistic models perform differently depending on categorization of outcome, adequacy in relation to assumptions, goodness-of-fit, and parsimony.O tema qualidade de vida tem ganhado ênfase nos últimos anos. Tipicamente os resultados da qualidade de vida são mensurados por meio de escalas ordinais. Procedimentos como dicotomizar a variável resposta e desconsiderar a ordenação geram perda de informação e podem ocasionar inferências incorretas. Para análise de dados ordinais, métodos estatísticos específicos são necessários, como modelos de regressão logística ordinal. A proposta deste trabalho é apresentar uma revisão dos modelos de chances proporcionais, de razão contínua, estereótipo e de chances proporcionais parciais. O ajuste, inferência estatística e comparação dos modelos são ilustrados com dados de um estudo sobre qualidade de vida realizado com 273 pacientes com esquizofrenia. Todos os modelos testados mostraram bom ajuste, mas o de chances

  17. Regression modeling strategies with applications to linear models, logistic and ordinal regression, and survival analysis

    CERN Document Server

    Harrell , Jr , Frank E

    2015-01-01

    This highly anticipated second edition features new chapters and sections, 225 new references, and comprehensive R software. In keeping with the previous edition, this book is about the art and science of data analysis and predictive modeling, which entails choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for fitting nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap.  The reader will gain a keen understanding of predictive accuracy, and the harm of categorizing continuous predictors or outcomes.  This text realistically...

  18. Food security and vulnerability modeling of East Java Province based on Geographically Weighted Ordinal Logistic Regression Semiparametric (GWOLRS model

    Directory of Open Access Journals (Sweden)

    N.W. Surya Wardhani

    2014-10-01

    Full Text Available Modeling of food security based on the characteristics of the area will be affected by the geographical location which means that geographical location will affect the region’s potential. Therefore, we need a method of statistical modeling that takes into account the geographical location or the location factor observations. In this case, the research variables could be global means that the location affects the response variables significantly; when some of the predictor variables are global and the other variables are local, then Geographically Weighted Ordinal Logistic Regression Semiparametric (GWOLRS could be used to analyze the data. The data used is the resilience and food insecurity data in 2011 in East Java Province. The result showed that three predictor variables that influenced by the location are the percentage of poor (%, rice production per district (tons and life expectancy (%. Those three predictor variables are local because they have significant influence in some districts/cities but had no significant effect in other districts/cities, while other two variables that are clean water and good quality road length (km are assumed global because it is not a significant factor for the whole districts/towns in East Java .

  19. Bayesian structural equations modeling for ordinal response data with missing responses and missing covariates

    CSIR Research Space (South Africa)

    Kim, S

    2009-01-01

    Full Text Available 6.01 Difierent background 8.86 Pay satisfaction 1.25 Supervisor support 7.27 Employee development 1.86 Customer satisfaction 6.83 Innovation 2.94 Employee satisfaction 1.43 Manager goals 5.28 Quality 1.38 Respect 1.48 Retention 0.83 Con ict... for by the facility efiect variability, in the latter the variability is accounted for by the structural dependency as well as the facility efiect. The structural part of the ordinal response SEM is given by ·ij = ¡·ij + »ij; (3.7) where »ij » N (0; diag( 2·1...

  20. The impact of tourists on Antarctic tardigrades: an ordination-based model

    Directory of Open Access Journals (Sweden)

    Sandra J. McInnes

    2013-05-01

    Full Text Available Tardigrades are important members of the Antarctic biota yet little is known about their role in the soil fauna or whether they are affected by anthropogenic factors. The German Federal Environment Agency commissioned research to assess the impact of human activities on soil meiofauna at 14 localities along the Antarctic peninsula during the 2009/2010 and 2010/2011 austral summers. We used ordination techniques to re-assess the block-sampling design used to compare areas of high and low human impact, to identify which of the sampled variables were biologically relevant and/or demonstrated an anthropogenic significance. We found the most significant differences between locations, reflecting local habitat and vegetation factor, rather than within-location anthropogenic impact. We noted no evidence of exotic imports but report on new maritime Antarctic sample sites and habitats.

  1. The importance of isomorphism for conclusions about homology: A Bayesian multilevel structural equation modeling approach with ordinal indicators

    Directory of Open Access Journals (Sweden)

    Nigel eGuenole

    2016-03-01

    Full Text Available We describe a Monte Carlo study examining the impact of assuming item isomorphism (i.e., equivalent construct meaning across levels of analysis on conclusions about homology (i.e., equivalent structural relations across levels of analysis under varying degrees of non-isomorphism in the context of ordinal indicator multilevel structural equation models (MSEMs. We focus on the condition where one or more loadings are higher on the between level than on the within level to show that while much past research on homology has ignored the issue of psychometric isomorphism, psychometric isomorphism is in fact critical to valid conclusions about homology. More specifically, when a measurement model with non-isomorphic items occupies an exogenous position in a multilevel structural model and the non-isomorphism of these items is not modeled, the within level exogenous latent variance is under-estimated leading to over-estimation of the within level structural coefficient, while the between level exogenous latent variance is overestimated leading to underestimation of the between structural coefficient. When a measurement model with non-isomorphic items occupies an endogenous position in a multilevel structural model and the non-isomorphism of these items is not modeled, the endogenous within level latent variance is under-estimated leading to under-estimation of the within level structural coefficient while the endogenous between level latent variance is over-estimated leading to over-estimation of the between level structural coefficient. The innovative aspect of this article is demonstrating that even minor violations of psychometric isomorphism render claims of homology untenable. We also show that posterior predictive p-values for ordinal indicator Bayesian MSEMs are insensitive to violations of isomorphism even when they lead to severely biased within and between level structural parameters. We highlight conditions where poor estimation of even

  2. The Importance of Isomorphism for Conclusions about Homology: A Bayesian Multilevel Structural Equation Modeling Approach with Ordinal Indicators.

    Science.gov (United States)

    Guenole, Nigel

    2016-01-01

    We describe a Monte Carlo study examining the impact of assuming item isomorphism (i.e., equivalent construct meaning across levels of analysis) on conclusions about homology (i.e., equivalent structural relations across levels of analysis) under varying degrees of non-isomorphism in the context of ordinal indicator multilevel structural equation models (MSEMs). We focus on the condition where one or more loadings are higher on the between level than on the within level to show that while much past research on homology has ignored the issue of psychometric isomorphism, psychometric isomorphism is in fact critical to valid conclusions about homology. More specifically, when a measurement model with non-isomorphic items occupies an exogenous position in a multilevel structural model and the non-isomorphism of these items is not modeled, the within level exogenous latent variance is under-estimated leading to over-estimation of the within level structural coefficient, while the between level exogenous latent variance is overestimated leading to underestimation of the between structural coefficient. When a measurement model with non-isomorphic items occupies an endogenous position in a multilevel structural model and the non-isomorphism of these items is not modeled, the endogenous within level latent variance is under-estimated leading to under-estimation of the within level structural coefficient while the endogenous between level latent variance is over-estimated leading to over-estimation of the between level structural coefficient. The innovative aspect of this article is demonstrating that even minor violations of psychometric isomorphism render claims of homology untenable. We also show that posterior predictive p-values for ordinal indicator Bayesian MSEMs are insensitive to violations of isomorphism even when they lead to severely biased within and between level structural parameters. We highlight conditions where poor estimation of even correctly specified

  3. Transductive Ordinal Regression

    CERN Document Server

    Seah, Chun-Wei; Ong, Yew-Soon

    2011-01-01

    Ordinal regression is commonly formulated as a multi-class problem with ordinal constraints. The challenge of designing accurate classifiers for ordinal regression generally increases with the number of classes involved, due to the large number of labeled patterns that are needed. The availability of ordinal class labels, however, are often costly to calibrate or difficult to obtain. Unlabeled patterns, on the other hand, often exist in much greater abundance and are freely available. To take benefits from the abundance of unlabeled patterns, we present a novel transductive learning paradigm for ordinal regression in this paper, namely Transductive Ordinal Regression (TOR). The key challenge of the present study lies in the precise estimation of both the ordinal class label of the unlabeled data and the decision functions of the ordinal classes, simultaneously. The core elements of the proposed TOR include an objective function that caters to several commonly used loss functions casted in transductive setting...

  4. Nested generalized linear mixed model with ordinal response: Simulation and application on poverty data in Java Island

    Science.gov (United States)

    Widyaningsih, Yekti; Saefuddin, Asep; Notodiputro, Khairil A.; Wigena, Aji H.

    2012-05-01

    The objective of this research is to build a nested generalized linear mixed model using an ordinal response variable with some covariates. There are three main jobs in this paper, i.e. parameters estimation procedure, simulation, and implementation of the model for the real data. At the part of parameters estimation procedure, concepts of threshold, nested random effect, and computational algorithm are described. The simulations data are built for 3 conditions to know the effect of different parameter values of random effect distributions. The last job is the implementation of the model for the data about poverty in 9 districts of Java Island. The districts are Kuningan, Karawang, and Majalengka chose randomly in West Java; Temanggung, Boyolali, and Cilacap from Central Java; and Blitar, Ngawi, and Jember from East Java. The covariates in this model are province, number of bad nutrition cases, number of farmer families, and number of health personnel. In this modeling, all covariates are grouped as ordinal scale. Unit observation in this research is sub-district (kecamatan) nested in district, and districts (kabupaten) are nested in province. For the result of simulation, ARB (Absolute Relative Bias) and RRMSE (Relative Root of mean square errors) scale is used. They show that prov parameters have the highest bias, but more stable RRMSE in all conditions. The simulation design needs to be improved by adding other condition, such as higher correlation between covariates. Furthermore, as the result of the model implementation for the data, only number of farmer family and number of medical personnel have significant contributions to the level of poverty in Central Java and East Java province, and only district 2 (Karawang) of province 1 (West Java) has different random effect from the others. The source of the data is PODES (Potensi Desa) 2008 from BPS (Badan Pusat Statistik).

  5. Bayesian hierarchical joint modeling of repeatedly measured continuous and ordinal markers of disease severity: Application to Ugandan diabetes data.

    Science.gov (United States)

    Buhule, O D; Wahed, A S; Youk, A O

    2017-08-22

    Modeling of correlated biomarkers jointly has been shown to improve the efficiency of parameter estimates, leading to better clinical decisions. In this paper, we employ a joint modeling approach to a unique diabetes dataset, where blood glucose (continuous) and urine glucose (ordinal) measures of disease severity for diabetes are known to be correlated. The postulated joint model assumes that the outcomes are from distributions that are in the exponential family and hence modeled as multivariate generalized linear mixed effects model associated through correlated and/or shared random effects. The Markov chain Monte Carlo Bayesian approach is used to approximate posterior distribution and draw inference on the parameters. This proposed methodology provides a flexible framework to account for the hierarchical structure of the highly unbalanced data as well as the association between the 2 outcomes. The results indicate improved efficiency of parameter estimates when blood glucose and urine glucose are modeled jointly. Moreover, the simulation studies show that estimates obtained from the joint model are consistently less biased and more efficient than those in the separate models. Copyright © 2017 John Wiley & Sons, Ltd.

  6. Description of waste pretreatment and interfacing systems dynamic simulation model

    Energy Technology Data Exchange (ETDEWEB)

    Garbrick, D.J.; Zimmerman, B.D.

    1995-05-01

    The Waste Pretreatment and Interfacing Systems Dynamic Simulation Model was created to investigate the required pretreatment facility processing rates for both high level and low level waste so that the vitrification of tank waste can be completed according to the milestones defined in the Tri-Party Agreement (TPA). In order to achieve this objective, the processes upstream and downstream of the pretreatment facilities must also be included. The simulation model starts with retrieval of tank waste and ends with vitrification for both low level and high level wastes. This report describes the results of three simulation cases: one based on suggested average facility processing rates, one with facility rates determined so that approximately 6 new DSTs are required, and one with facility rates determined so that approximately no new DSTs are required. It appears, based on the simulation results, that reasonable facility processing rates can be selected so that no new DSTs are required by the TWRS program. However, this conclusion must be viewed with respect to the modeling assumptions, described in detail in the report. Also included in the report, in an appendix, are results of two sensitivity cases: one with glass plant water recycle steams recycled versus not recycled, and one employing the TPA SST retrieval schedule versus a more uniform SST retrieval schedule. Both recycling and retrieval schedule appear to have a significant impact on overall tank usage.

  7. Modeling the proportion of cut slopes rock on forest roads using artificial neural network and ordinal linear regression.

    Science.gov (United States)

    Babapour, R; Naghdi, R; Ghajar, I; Ghodsi, R

    2015-07-01

    Rock proportion of subsoil directly influences the cost of embankment in forest road construction. Therefore, developing a reliable framework for rock ratio estimation prior to the road planning could lead to more light excavation and less cost operations. Prediction of rock proportion was subjected to statistical analyses using the application of Artificial Neural Network (ANN) in MATLAB and five link functions of ordinal logistic regression (OLR) according to the rock type and terrain slope properties. In addition to bed rock and slope maps, more than 100 sample data of rock proportion were collected, observed by geologists, from any available bed rock of every slope class. Four predictive models were developed for rock proportion, employing independent variables and applying both the selected probit link function of OLR and Layer Recurrent and Feed forward back propagation networks of Neural Networks. In ANN, different numbers of neurons are considered for the hidden layer(s). Goodness of the fit measures distinguished that ANN models produced better results than OLR with R (2) = 0.72 and Root Mean Square Error = 0.42. Furthermore, in order to show the applicability of the proposed approach, and to illustrate the variability of rock proportion resulted from the model application, the optimum models were applied to a mountainous forest in where forest road network had been constructed in the past.

  8. Thermochemical pretreatment of lignocellulose to enhance methane fermentation: II. Evaluation and application of pretreatment model.

    Science.gov (United States)

    Baugh, K D; Levy, J A; McCarty, P L

    1988-01-01

    A model was developed and evaluated as a tool for predicting the formation of soluble products from staged thermochemical treatment of lignocellulosic materials under acidic conditions typical of autohydrolysis. The model was used to predict the general trend of hemi-cellulose and cellulose hydrolysis between pH 2 and 4 and temperatures of 170-230 degrees C, and results were compared with experimental data. When the model was evaluated for this range of temperatures and pH values, results indicated: (1) a relatively low temperature (175 degrees C) during the first stage allows hydrolysis of the hemi-cellulose polysaccharides without significant mono-saccharide decomposition, (2) subsequent stages at higher temperatures (equal or greater than 200 degrees C) are needed for significant cellulose hydrolysis, but glucose decomposition will also occur, and, (3) a pH in the range of 2-2.5 will enhance polysaccharide hydrolysis while limiting monosaccharide decomposition. The model's predictions, indicating that the formation of biodegradable products could be optimized using Pretreatments at pH 2-2.5 for the pH range evaluated, were confirmed in experiments with white fir as a representative lig nocellulose.

  9. ISA-MIP: A co-ordinated intercomparison of Interactive Stratospheric Aerosol models

    Science.gov (United States)

    Timmreck, Claudia; Mann, Graham; Aquila, Valentina; Bruehl, Christoph; Chin, Mian; Dohmse, Sandip; English, Jason; Lee, Lindsay; Mills, Michael; Hommel, Rene; Neely, Ryan; Schmidt, Anja; Sheng, Jianxiong; Toohey, Matthew; Weisenstein, Debra

    2016-04-01

    The SPARC activity, "Stratospheric Sulfur and its Role in Climate" (SSiRC) was initiated to coordinate international research activities on modelling and observation of stratospheric sulphate aerosols (and precursor gases) in order to assess its climate forcing and feedback. With several international activities to extend and improve observational stratospheric aerosol capabilities and data sets, and a growing number of global models treating stratospheric aerosol interactively, a new model intercomparison activity "ISA-MIP" has been established in the frame of SSIRC. ISA-MIP will compare interactive stratospheric aerosol (ISA) models using a range of observations to constrain and improve the models and to provide a sound scientific basis for future work. Four ISA-MIP experiments have been designed to assess different periods of the obervational stratospheric aerosol record, and to explore key processes which influence the formation and temporal development of stratospheric aerosol. The "Background" experiment will focus on the role of microphysical and transport processes under volcanically quiescent conditions, where the stratospheric aerosol size distribution is only modulated by seasonal circulations. The "Model intercomparison of Transient Aerosol Record" (MiTAR) experiment will focus on addressing the role of small- to moderate-magnitude volcanic eruptions and transport processes in the upper troposphere - lower stratosphere (UTLS) aerosols loading over the period 1998-2011. Background and MiTAR simulations will be compared to recent in-situ and satellite observations to evaluate the performances of the model and understand their strengths and weaknesses. Two further experiments investigate the radiative forcing from historical major eruptions. The Historical Eruptions SO2 Emission Assessment (HErSEA) will involve models carrying out mini-ensembles of the stratospheric aerosol perturbations from each of the 1963 Agung, 1982 El Chichon and 1991 Pinatubo

  10. Radiative Transfer Modeling of a Large Pool Fire by Discrete Ordinates, Discrete Transfer, Ray Tracing, Monte Carlo and Moment Methods

    Science.gov (United States)

    Jensen, K. A.; Ripoll, J.-F.; Wray, A. A.; Joseph, D.; ElHafi, M.

    2004-01-01

    Five computational methods for solution of the radiative transfer equation in an absorbing-emitting and non-scattering gray medium were compared on a 2 m JP-8 pool fire. The temperature and absorption coefficient fields were taken from a synthetic fire due to the lack of a complete set of experimental data for fires of this size. These quantities were generated by a code that has been shown to agree well with the limited quantity of relevant data in the literature. Reference solutions to the governing equation were determined using the Monte Carlo method and a ray tracing scheme with high angular resolution. Solutions using the discrete transfer method, the discrete ordinate method (DOM) with both S(sub 4) and LC(sub 11) quadratures, and moment model using the M(sub 1) closure were compared to the reference solutions in both isotropic and anisotropic regions of the computational domain. DOM LC(sub 11) is shown to be the more accurate than the commonly used S(sub 4) quadrature technique, especially in anisotropic regions of the fire domain. This represents the first study where the M(sub 1) method was applied to a combustion problem occurring in a complex three-dimensional geometry. The M(sub 1) results agree well with other solution techniques, which is encouraging for future applications to similar problems since it is computationally the least expensive solution technique. Moreover, M(sub 1) results are comparable to DOM S(sub 4).

  11. Modelización de Competencias Ordinales en Escolares de 3 a 6 Años (Modelization of Ordinal Competences in 3 to 6 Years Old Students

    Directory of Open Access Journals (Sweden)

    Catalina Fernández

    2009-06-01

    Full Text Available En este artículo se presenta un modelo evolutivo de competencias ordinales que consta de 6 estados de conocimiento empíricamente validados. Se describe un estudio empírico exploratorio que constó de entrevistas clínicas individuales y cuyo objetivo era analizar el conocimiento de los niños sobre la relación lógica ordinal de siguiente inmediato. Los resultados obtenidos sirvieron para determinar los estados evolutivos de los que consta el modelo. Dicho modelo se validó mediante una prueba de 6 tareas, cada una de las cuales presentaba las características lógicas matemáticas propias de uno de los estados del modelo. In this paper we present a developmental model of ordinal competence which consists of 6 empirically validated states of knowledge. An exploratory empirical study was carried out with individual clinical interviews. The aim was to analyze children’s knowledge about the logical-ordinal relationship of the immediately next term. The results obtained served to determine the developmental stages of the model. The model was validated through a test comprising 6 tasks, each of which presented the mathematical and logical characteristics of a given state of the model.

  12. Ordinal Comparison of Multidimensional Deprivation

    DEFF Research Database (Denmark)

    Sonne-Schmidt, Christoffer Scavenius; Tarp, Finn; Østerdal, Lars Peter

    This paper develops an ordinal method of comparison of multidimensional inequality. In our model, population distribution g is more unequal than f when the distributions have common median and can be obtained from f  by one or more shifts in population density that increase inequality. For our be...... benchmark 2x2 case (i.e. the case of two binary outcome variables), we derive an empirical method for making inequality comparisons. As an illustration, we apply the model to childhood poverty in Mozambique.......This paper develops an ordinal method of comparison of multidimensional inequality. In our model, population distribution g is more unequal than f when the distributions have common median and can be obtained from f  by one or more shifts in population density that increase inequality. For our...

  13. Finite Element Modelling of Infinite Euler Beams on Kelvin Foundations Exposed to Moving Loads in Convected Co-ordinates

    DEFF Research Database (Denmark)

    Andersen, Lars; Nielsen, Søren R.K.; Kirkegaard, Poul Henning

    2001-01-01

    The paper deals with the finite element method (FEM) solution of the problem with loads moving uniformly along an infinite Euler beam supported by a linear elastic Kelvin foundation with linear viscous damping. Initially, the problem is formulatedin a moving co-ordinate system following the load...

  14. Evaluation of a weighted test in the analysis of ordinal gait scores in an additivity model for five OP pesticides.

    Science.gov (United States)

    Appropriate statistical analyses are critical for evaluating interactions of mixtures with a common mode of action, as is often the case for cumulative risk assessments. Our objective is to develop analyses for use when a response variable is ordinal, and to test for interaction...

  15. A bio-inspired, computational model suggests velocity gradients of optic flow locally encode ordinal depth at surface borders and globally they encode self-motion.

    Science.gov (United States)

    Raudies, Florian; Ringbauer, Stefan; Neumann, Heiko

    2013-09-01

    Visual navigation requires the estimation of self-motion as well as the segmentation of objects from the background. We suggest a definition of local velocity gradients to compute types of self-motion, segment objects, and compute local properties of optical flow fields, such as divergence, curl, and shear. Such velocity gradients are computed as velocity differences measured locally tangent and normal to the direction of flow. Then these differences are rotated according to the local direction of flow to achieve independence of that direction. We propose a bio-inspired model for the computation of these velocity gradients for video sequences. Simulation results show that local gradients encode ordinal surface depth, assuming self-motion in a rigid scene or object motions in a nonrigid scene. For translational self-motion velocity, gradients can be used to distinguish between static and moving objects. The information about ordinal surface depth and self-motion can help steering control for visual navigation.

  16. Waste pretreatment and interfacing system dynamic simulation model (ITHINK model) FY-96 year-end report

    Energy Technology Data Exchange (ETDEWEB)

    Harmsen, R.W.

    1996-09-30

    The Waste Pretreatment and Interfacing Systems Dynamic Simulation (ITHINK) Model (see WHC-SD-WM-DR-013) was originally created to investigate the required pretreatment facility processing rates required to meet the Tri-Party Agreement (TPA) waste vitrification milestones. The TPA milestones are satisfied by retrieving the TX tank farm (salt cake) single-shell tanks (SSTs)first and by utilizing a relatively constant retrieval rate to the year 2018 when retrieval is completed.

  17. Ordinals in Frobenius Monads

    CERN Document Server

    Dosen, K

    2008-01-01

    This paper provides geometrical descriptions of the Frobenius monad freely generated by a single object. These descriptions are related to results connecting Frobenius algebras and topological quantum field theories. In these descriptions, which are based on coherence results for self-adjunctions (adjunctions where an endofunctor is adjoint to itself), ordinals in $\\epsilon_0$ play a prominent role. The paper ends by considering how the notion of Frobenius algebra induces the collapse of the hierarchy of ordinals in $\\epsilon_0$, and by raising the question of the exact categorial abstraction of the notion of Frobenius algebra.

  18. Revision without ordinals

    NARCIS (Netherlands)

    Rivello, Edoardo

    2013-01-01

    We show that Herzberger’s and Gupta’s revision theories of truth can be recast in purely inductive terms, without any appeal neither to the transfinite ordinal numbers nor to the axiom of Choice. The result is presented in an abstract and general setting, emphasising both its validity for a wide ran

  19. An analytical discrete ordinates solution for a nodal model of a two-dimensional neutron transport problem

    Energy Technology Data Exchange (ETDEWEB)

    Filho, J. F. P. [Institute de Matematica, Estatistica e Fisica, Universidade Federal do Rio Grande, Av. Italia, s/n, 96203-900 Rio Grande, RS (Brazil); Barichello, L. B. [Institute de Matematica, Universidade Federal do Rio Grande do Sul, Av. Bento Goncalves, 9500, 91509-900 Porto Alegre, RS (Brazil)

    2013-07-01

    In this work, an analytical discrete ordinates method is used to solve a nodal formulation of a neutron transport problem in x, y-geometry. The proposed approach leads to an important reduction in the order of the associated eigenvalue systems, when combined with the classical level symmetric quadrature scheme. Auxiliary equations are proposed, as usually required for nodal methods, to express the unknown fluxes at the boundary introduced as additional unknowns in the integrated equations. Numerical results, for the problem defined by a two-dimensional region with a spatially constant and isotropically emitting source, are presented and compared with those available in the literature. (authors)

  20. Ordinal Comparison of Multidimensional Deprivation

    DEFF Research Database (Denmark)

    Sonne-Schmidt, Christoffer Scavenius; Tarp, Finn; Østerdal, Lars Peter

    This paper develops an ordinal method of comparison of multidimensional inequality. In our model, population distribution g is more unequal than f when the distributions have common median and can be obtained from f  by one or more shifts in population density that increase inequality. For our be...... benchmark 2x2 case (i.e. the case of two binary outcome variables), we derive an empirical method for making inequality comparisons. As an illustration, we apply the model to childhood poverty in Mozambique....

  1. Modelling of pretreatment and saccharification with different feedstocks and kinetic modeling of sorghum saccharification.

    Science.gov (United States)

    Prathyusha, N; Kamesh, Reddi; Rani, K Yamuna; Sumana, C; Sridhar, S; Prakasham, R S; Yashwanth, V V N; Sheelu, G; Kumar, M Pradeep

    2016-12-01

    Experiments have been performed for pretreatment of sorghum, wheat straw and bamboo through high temperature alkali pretreatment with different alkaline loading and temperatures, and the data on extent of delignification in terms of the final compositions of cellulose, hemicellulose and lignin have been generated. Further, enzymatic saccharification has been carried out in all the cases to find the extent of conversion possible after 72h. The effect of different operating parameters on the extent of delignification and cellulose conversion are evaluated. This data is employed to develop a generalized multi-feedstock and individual feedstock based models which can be used to determine the extent of delignification and cellulose conversion for any and specific biomass respectively with alkaline pretreatment and similar enzyme conditions as considered in the present study. Also, a kinetic model is developed and validated for sorghum for cellulosic conversion.

  2. Calculations of non-gray gas radiative heat transfer by coupling the discrete ordinates method with the Leckner model in 3D rectangular enclosures

    Science.gov (United States)

    Fathi Azarkhavarani, M. E.; Hosseini Abardeh, R.; Rahmani, M.

    2015-12-01

    In this study a new approach for radiation heat flux calculations by coupling the discrete ordinates method with the Leckner global model is introduced. The aim is to analyze the radiative heat transfer problem within a three-dimensional enclosure filled with non-gray gas mixture of H2O and CO2 . A computer code developed by this approach is applied to radiative calculations in three groups of well-known test cases published previously; considering homogeneous and inhomogeneous isothermal and non-isothermal participating media. All results are compared with well-known calculations based on statistical narrow band model. Also a new series of predictions for a medium with non-black walls and various mixture of H2O and CO2 is performed to demonstrate the applicability of the Leckner model. The effect of different compositions of H2O and CO2 on the radiative transfer within modern combustors is also examined. Based on the results obtained, it is believed that the discrete ordinates method coupled with the Leckner global model despite of its inherent simplicity and low computational cost is sufficiently accurate. For its convenient use, this method is suitable for a wide range of engineering calculations of participating media as well as for its link to previously written computational fluid dynamics codes.

  3. Low dose of lipopolysaccharide pretreatment can alleviate the inflammatory response in wound infection mouse model

    Institute of Scientific and Technical Information of China (English)

    Dong Wang; Yang Liu; Yan-Rui Zhao; Jun-Lin Zhou

    2016-01-01

    Purpose:To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo.Methods:Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial longitudinal incision was made and infected with different bacteria.Results:It is showed that 0.5 mg/kg/time of LPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus,methicillin-sensitive S.aureus,Pseudomonas aeruginosa,or Escherichia coli compared with doses of 0.25 mg/kg/time,1 mg/kg/time,and 1.5 mg/kg/time.Conclusions:LP5 pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time,and meanwhile it does not damage organs' function.

  4. Regenerating time series from ordinal networks

    Science.gov (United States)

    McCullough, Michael; Sakellariou, Konstantinos; Stemler, Thomas; Small, Michael

    2017-03-01

    Recently proposed ordinal networks not only afford novel methods of nonlinear time series analysis but also constitute stochastic approximations of the deterministic flow time series from which the network models are constructed. In this paper, we construct ordinal networks from discrete sampled continuous chaotic time series and then regenerate new time series by taking random walks on the ordinal network. We then investigate the extent to which the dynamics of the original time series are encoded in the ordinal networks and retained through the process of regenerating new time series by using several distinct quantitative approaches. First, we use recurrence quantification analysis on traditional recurrence plots and order recurrence plots to compare the temporal structure of the original time series with random walk surrogate time series. Second, we estimate the largest Lyapunov exponent from the original time series and investigate the extent to which this invariant measure can be estimated from the surrogate time series. Finally, estimates of correlation dimension are computed to compare the topological properties of the original and surrogate time series dynamics. Our findings show that ordinal networks constructed from univariate time series data constitute stochastic models which approximate important dynamical properties of the original systems.

  5. Regenerating time series from ordinal networks.

    Science.gov (United States)

    McCullough, Michael; Sakellariou, Konstantinos; Stemler, Thomas; Small, Michael

    2017-03-01

    Recently proposed ordinal networks not only afford novel methods of nonlinear time series analysis but also constitute stochastic approximations of the deterministic flow time series from which the network models are constructed. In this paper, we construct ordinal networks from discrete sampled continuous chaotic time series and then regenerate new time series by taking random walks on the ordinal network. We then investigate the extent to which the dynamics of the original time series are encoded in the ordinal networks and retained through the process of regenerating new time series by using several distinct quantitative approaches. First, we use recurrence quantification analysis on traditional recurrence plots and order recurrence plots to compare the temporal structure of the original time series with random walk surrogate time series. Second, we estimate the largest Lyapunov exponent from the original time series and investigate the extent to which this invariant measure can be estimated from the surrogate time series. Finally, estimates of correlation dimension are computed to compare the topological properties of the original and surrogate time series dynamics. Our findings show that ordinal networks constructed from univariate time series data constitute stochastic models which approximate important dynamical properties of the original systems.

  6. Proposed Ordinance for the Regulation of Cable Television. Working Draft.

    Science.gov (United States)

    Chicago City Council, IL.

    A model ordinance is proposed for the regulation of cable television in the city of Chicago. It defines the language of the ordinance, sets forth the method of granting franchises, and describes the terms of the franchises. The duties of a commission to regulate cable television are listed and the method of selecting commission members is…

  7. 定序变量回归模型在心理数据分析中的应用%A Regression Analysis Model of Ordinal Variable to Psychological Data

    Institute of Scientific and Technical Information of China (English)

    徐芃; 祁禄; 熊健; 叶浩生

    2015-01-01

    定序变量在心理现象和心理数据中随处可见, 采用综合的定序变量回归分析模型可以对"镜像模式"和"漏斗模型"的心理现象做出合理的解释和预测.首先通过非参数检验对影响因素进行初步降维, 其次用 Probit 定序回归对降维后的影响因素贡献率进行判别, 从而进一步筛选具有显著性判断水平的有效指标,最后用Logistic回归模型对某种特定的心理现象发生与否进行信息量足够大的解释和预测.大学毕业生工作生活质量满意度的预测对这种综合定序变量回归分析模型的实例拟合, 证实了综合定序变量回归分析模型在心理现象和心理数据分析中的应用价值.%Ordinal variables are the common form of categorical variables in random phenomenon. Ordinal data which is formed from the level of ordinal variables by sequencing scale measurement has been widely used in psychological research. Psychological data is a kind of data from randomized hidden variable, which seems to be noticeable but could not be touched such as degree of satisfaction, preference degree, cognition degree, sentiment perceptibility, behavioral level and so on. The mental impression is hard to be calculated. To be exposed for calculated ordinal data is a kind of judgment standard or decision threshold criteria of an individual psychological activity in implicit psychological data. When a certain degree of psychological feeling happens to be just between two adjacent thresholds, the individual would be given a numerical value like a scale to project this "Mirror mode" of the psychological decision threshold criteria. Meanwhile, people are always concerned about what factors or conditions decide the high-low of threshold value of these ordinal variables based on cognitive instinct. This sort of "Hopper model" which is used to study the factors affecting to the psychological decision threshold criteria is a typical regression model. The paper

  8. A Rational Decision Maker with Ordinal Utility under Uncertainty: Optimism and Pessimism

    CERN Document Server

    Han, Ji

    2009-01-01

    In game theory and artificial intelligence, decision making models often involve maximizing expected utility, which does not respect ordinal invariance. In this paper, the author discusses the possibility of preserving ordinal invariance and still making a rational decision under uncertainty.

  9. Modeling of a continuous pretreatment reactor using computational fluid dynamics.

    Science.gov (United States)

    Berson, R Eric; Dasari, Rajesh K; Hanley, Thomas R

    2006-01-01

    Computational fluid dynamic simulations are employed to predict flow characteristics in a continuous auger driven reactor designed for the dilute acid pretreatment of biomass. Slurry containing a high concentration of biomass solids exhibits a high viscosity, which poses unique mixing issues within the reactor. The viscosity increases significantly with a small increase in solids concentration and also varies with temperature. A well-mixed slurry is desirable to evenly distribute acid on biomass, prevent buildup on the walls of the reactor, and provides an uniform final product. Simulations provide flow patterns obtained over a wide range of viscosities and pressure distributions, which may affect reaction rates. Results provide a tool for analyzing sources of inconsistencies in product quality and insight into future design and operating parameters.

  10. Modeling changes in biomass composition during microwave-based alkali pretreatment of switchgrass.

    Science.gov (United States)

    Keshwani, Deepak R; Cheng, Jay J

    2010-01-01

    This study used two different approaches to model changes in biomass composition during microwave-based pretreatment of switchgrass: kinetic modeling using a time-dependent rate coefficient, and a Mamdani-type fuzzy inference system. In both modeling approaches, the dielectric loss tangent of the alkali reagent and pretreatment time were used as predictors for changes in amounts of lignin, cellulose, and xylan during the pretreatment. Training and testing data sets for development and validation of the models were obtained from pretreatment experiments conducted using 1-3% w/v NaOH (sodium hydroxide) and pretreatment times ranging from 5 to 20 min. The kinetic modeling approach for lignin and xylan gave comparable results for training and testing data sets, and the differences between the predictions and experimental values were within 2%. The kinetic modeling approach for cellulose was not as effective, and the differences were within 5-7%. The time-dependent rate coefficients of the kinetic models estimated from experimental data were consistent with the heterogeneity of individual biomass components. The Mamdani-type fuzzy inference was shown to be an effective approach to model the pretreatment process and yielded predictions with less than 2% deviation from the experimental values for lignin and with less than 3% deviation from the experimental values for cellulose and xylan. The entropies of the fuzzy outputs from the Mamdani-type fuzzy inference system were calculated to quantify the uncertainty associated with the predictions. Results indicate that there is no significant difference between the entropies associated with the predictions for lignin, cellulose, and xylan. It is anticipated that these models could be used in process simulations of bioethanol production from lignocellulosic materials.

  11. Evaluation of high-level waste pretreatment processes with an approximate reasoning model

    Energy Technology Data Exchange (ETDEWEB)

    Bott, T.F.; Eisenhawer, S.W.; Agnew, S.F.

    1999-04-01

    The development of an approximate-reasoning (AR)-based model to analyze pretreatment options for high-level waste is presented. AR methods are used to emulate the processes used by experts in arriving at a judgment. In this paper, the authors first consider two specific issues in applying AR to the analysis of pretreatment options. They examine how to combine quantitative and qualitative evidence to infer the acceptability of a process result using the example of cesium content in low-level waste. They then demonstrate the use of simple physical models to structure expert elicitation and to produce inferences consistent with a problem involving waste particle size effects.

  12. Dynamic Modeling and Validation of a Biomass Hydrothermal Pretreatment Process - A Demonstration Scale Study

    DEFF Research Database (Denmark)

    Prunescu, Remus Mihail; Blanke, Mogens; Jakobsen, Jon Geest

    2015-01-01

    Hydrothermal pretreatment of lignocellulosic biomass is a cost effective technology for second generation biorefineries. The process occurs in large horizontal and pressurized thermal reactors where the biomatrix is opened under the action of steam pressure and temperature to expose cellulose...... for the enzymatic hydrolysis process. Several by-products are also formed, which disturb and act as inhibitors downstream. The objective of this study is to formulate and validate a large scale hydrothermal pretreatment dynamic model based on mass and energy balances, together with a complex conversion mechanism...... of the process, outlining the value of the model for simulation, control design, and optimization for full-scale applications....

  13. The determinants of the growth expectations of the early-stage entrepreneurs (TEA using the ordinal logistic model (OLM: the case of Turkey

    Directory of Open Access Journals (Sweden)

    Ahmet Özçam

    2010-01-01

    Full Text Available This study uses the Ordinal Logistic Model (OLM to analyze the determinants of the growth expectations of total early-stage entrepreneurship activity (TEA expressed in terms of new jobs to be created within their firms in four categories. Specifically, given the increasing importance of entrepreneurship in job creation, innovation and economic growth, we try to inquire into the question of why some of the new entrepreneurs and not the others expect a rapid development of their ventures. The data from the Global Entrepreneurship Monitor (GEM for the years 2006-2008 for Turkey were employed. Our findings indicate that the personal characteristics of the early-stage Turkish entrepreneurs such as gender, education and household income, in addition to their motivation and current size of their businesses are important factors in resolving the prevalence of high-expectation new firms. Moreover, some scenarios particular to some sub-groups or population cells of Turkish developing entrepreneurs which may create the bulk of high-expectation entrepreneurial pursuit were conducted using OLM. As far as the policy implications are concerned, the availability and access of capital funding to early-stage entrepreneurs and an education system more relevant to today’s competitive world might both contribute better to Turkish economy’s prosperity, and seems to be very important for policy considerations.

  14. A single cell model for pretreatment of wood by microwave explosion

    Science.gov (United States)

    Xianjun Li; Yongdong Zhou; Yonglin Yan; Zhiyong Cai; Fu Feng

    2010-01-01

    A theoretical model was developed to better understand the process of microwave explosion treatment of wood cells. The cell expansion and critical conditions concerning pressure and temperature of ray parenchyma cells in Eucalyptus urophylla were simulated during microwave pretreatment. The results indicate that longitudinal and circumferential stresses were generated...

  15. Semi-supervised learning for ordinal Kernel Discriminant Analysis.

    Science.gov (United States)

    Pérez-Ortiz, M; Gutiérrez, P A; Carbonero-Ruz, M; Hervás-Martínez, C

    2016-12-01

    Ordinal classification considers those classification problems where the labels of the variable to predict follow a given order. Naturally, labelled data is scarce or difficult to obtain in this type of problems because, in many cases, ordinal labels are given by a user or expert (e.g. in recommendation systems). Firstly, this paper develops a new strategy for ordinal classification where both labelled and unlabelled data are used in the model construction step (a scheme which is referred to as semi-supervised learning). More specifically, the ordinal version of kernel discriminant learning is extended for this setting considering the neighbourhood information of unlabelled data, which is proposed to be computed in the feature space induced by the kernel function. Secondly, a new method for semi-supervised kernel learning is devised in the context of ordinal classification, which is combined with our developed classification strategy to optimise the kernel parameters. The experiments conducted compare 6 different approaches for semi-supervised learning in the context of ordinal classification in a battery of 30 datasets, showing (1) the good synergy of the ordinal version of discriminant analysis and the use of unlabelled data and (2) the advantage of computing distances in the feature space induced by the kernel function.

  16. Scoring ordinal variables for constructing composite indicators

    Directory of Open Access Journals (Sweden)

    Marica Manisera

    2013-05-01

    Full Text Available In order to provide composite indicators of latent variables, for example of customer satisfaction, it is opportune to identify the structure of the latent variable, in terms of the assignment of items to the subscales defining the latent variable. Adopting the reflective model, the impact of four different methods of scoring ordinal variables on the identification of the true structure of latent variables is investigated. A simulation study composed of 5 steps is conducted: (1 simulation of population data with continuous variables measuring a two-dimensional latent variable with known structure; (2 draw of a number of random samples; (3 discretization of the continuous variables according to different distributional forms; (4 quantification of the ordinal variables obtained in step (3 according to different methods; (5 construction of composite indicators and verification of the correct assignment of variables to subscales by the multiple group method and the factor analysis. Results show that the considered scoring methods have similar performances in assigning items to subscales, and that, when the latent variable is multinormal, the distributional form of the observed ordinal variables is not determinant in suggesting the best scoring method to use.

  17. Modelling and L1 Adaptive Control of Temperature in Biomass Pretreatment

    DEFF Research Database (Denmark)

    Prunescu, Remus Mihail; Blanke, Mogens; Sin, Gürkan

    2013-01-01

    Biomass steam pretreatment is a key process in converting agricultural wastes to bioethanol. The pretreatment occurs in a large pressurized tank called a thermal reactor. Two key parameters influence the successfulness of the process: the reactor temperature, and the retention time. A particle pump...... pressurizes untreated biomass from atmospheric to reactor pressure with recycled steam from the reactor. This paper formulates a steam mathematical model both for the thermal reactor and the particle pump, which is then used to design an L1 adaptive output feedback controller for the reactor temperature....... As steam is recycled from the reactor to pressurize the particle pump, pressure drops and the reactor temperature is disturbed. The main control challenge is to reject these disturbances and keep a steady temperature. The nonlinear process model embeds mass and energy balances, valve characteristics...

  18. Dynamic Modeling and Validation of a Biomass Hydrothermal Pretreatment Process - A Demonstration Scale Study

    DEFF Research Database (Denmark)

    Prunescu, Remus Mihail; Blanke, Mogens; Jakobsen, Jon Geest;

    2015-01-01

    Hydrothermal pretreatment of lignocellulosic biomass is a cost effective technology for second generation biorefineries. The process occurs in large horizontal and pressurized thermal reactors where the biomatrix is opened under the action of steam pressure and temperature to expose cellulose for...... of the process, outlining the value of the model for simulation, control design, and optimization for full-scale applications. This article is protected by copyright. All rights reserved....

  19. Genetic analysis of the twenty-one-day pregnancy rate in US Holsteins using an ordinal censored threshold model with unknown voluntary waiting period.

    Science.gov (United States)

    Chang, Y M; González-Recio, O; Weigel, K A; Fricke, P M

    2007-04-01

    Genetic variation in the number of 21-d opportunity periods required to achieve pregnancy after the voluntary waiting period (VWP) had passed was examined using 44,901 lactation records of 29,422 lactating Holstein cows on 61 large commercial dairy farms in the United States. Cows were allowed a maximum of 8 opportunity periods, and the cumulative percentages of cows that became pregnant by the end of the first, second, third, fourth, and fifth opportunity periods were 19, 29, 37, 43, and 47%, respectively. In addition, 38% of records were censored because of culling or failure to achieve pregnancy after 8 opportunity periods. Mean days open was 128 d for complete records, whereas mean days to last service was 148 d for censored records. An ordinal censored threshold model was developed, in which duration of the VWP was estimated simultaneously with prediction of sire breeding values. The posterior mean of intraherd-year heritability for the number of 21-d opportunity periods required to achieve pregnancy was 0.06, with a posterior standard deviation of 0.01. Posterior means for duration of the VWP ranged from 28 to 74 d postpartum among the 116 herd-parity classes represented in the study, whereas farmer-reported survey values for duration of the VWP ranged from 30 to 78 d postpartum. Sires' predicted transmitting abilities were computed, assuming an unknown VWP (i.e., estimated from the data), a VWP fixed at 60 d postpartum, or a VWP fixed at farmer survey values. Correlations among sire predicted transmitting abilities from different models were > or = 0.98, although some reranking occurred among top sires. In summary, the proposed model for genetic evaluation of female fertility can accommodate heterogeneity in duration of the VWP between herds, as well as heterogeneity that may arise within herds owing to management practices such as intentional delay of first insemination in high-producing cows or cows with poor body condition, and it can also accommodate

  20. Coupling of a discrete ordinate 3-D radiant heat transfer model with the PHOENICS fluid mechanics software; Couplage d`un modele radiatif tridimensionnel aux ordonnees discretes au logiciel de mecanique des fluides phoenics

    Energy Technology Data Exchange (ETDEWEB)

    Muller, J. [IRSID, Institut de Recherches Siderurgie, 57 - Maizieres-les-Metz (France)

    1996-12-31

    Radiant heat transfer is the main solution retained in many iron and steel metallurgy installations (re-heating and annealing furnaces etc..). Today, it has become important to dispose of performing radiant heat transfer models in heat transfer and fluid mechanics simulation softwares, and well adapted to multidimensional industrial problems. This work presents the discrete ordinate radiant heat transfer model developed at the IRSID (the French institute of research in iron and steel metallurgy) and coupled with the PHOENICS heat transfer-fluid mechanics software. Three modeling approaches are presented concerning the radiative properties of gases (H{sub 2}O-CO{sub 2}). A ``weighted grey gases sum`` model gives satisfactory results for several 1-D validation cases. (J.S.) 20 refs.

  1. Isoforskolin pretreatment attenuates lipopolysaccharide-induced acute lung injury in animal models.

    Science.gov (United States)

    Yang, Weimin; Qiang, Dongjin; Zhang, Min; Ma, Limei; Zhang, Yonghui; Qing, Chen; Xu, Yunlong; Zhen, Chunlan; Liu, Jikai; Chen, Yan-Hua

    2011-06-01

    Isoforskolin was isolated from Coleus forskohlii native to Yunnan in China. We hypothesize that isoforskolin pretreatment attenuates acute lung injury induced by lipopolysaccharide (endotoxin). Three acute lung injury models were used: situ perfused rat lung, rat and mouse models of endotoxic shock. Additionally, lipopolysaccharide stimulated proinflammatory cytokine production was evaluated in human mononuclear leukocyte. In situ perfused rat lungs, pre-perfusion with isoforskolin (100, and 200 μM) and dexamethasone (65 μM, positive control) inhibited lipopolysaccharide (10 mg/L) induced increases in lung neutrophil adhesion rate, myeloperoxidase activity, lung weight Wet/Dry ratio, permeability-surface area product value, and tumor necrosis factor (TNF)-α levels. In rats, pretreatments with isoforskolin (5, 10, and 20 mg/kg, i.p.) and dexamethasone (5mg/kg, i.p.) markedly reduced lipopolysaccharide (6 mg/kg i.v.) induced increases of karyocyte, neutrophil counts and protein content in bronchoalveolar lavage fluid, and plasma myeloperoxidase activity. Lung histopathology showed that morphologic changes induced by lipopolysaccharide were less pronounced in the isoforskolin and dexamethasone pretreated rats. In mice, 5 mg/kg isoforskolin and dexamethasone caused 100% and 80% survival, respectively, after administration of lipopolysaccharide (62.5mg/kg, i.v., 40% survival if untreated). In human mononuclear leukocyte, isoforskolin (50, 100, and 200 μM) and dexamethasone (10 μM) pre-incubation lowered lipopolysaccharide (2 μg/mL) induced secretion of the cytokine TNF-α, and interleukins (IL)-1β, IL-6, and IL-8. In conclusion, pretreatment with isoforskolin attenuates lipopolysaccharide-induced acute lung injury in several models, and it is involved in down-regulation of inflammatory responses and proinflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8.

  2. 40 CFR 403.9 - POTW pretreatment programs and/or authorization to revise pretreatment standards: Submission for...

    Science.gov (United States)

    2010-07-01

    ...-MENT REGULATIONS FOR EXIST-ING AND NEW SOURCES OF POLLUTION § 403.9 POTW pretreatment programs and/or... applied to individual Industrial Users (e.g., by order, permit, ordinance, etc.); and, (iii) Identify how... them in the event of noncompliance by Industrial Users; (2) A copy of any statutes, ordinances...

  3. Measure and integral with purely ordinal scales

    CERN Document Server

    Denneberg, Dieter

    2008-01-01

    We develop a purely ordinal model for aggregation functionals for lattice valued functions, comprising as special cases quantiles, the Ky Fan metric and the Sugeno integral. For modeling findings of psychological experiments like the reflection effect in decision behaviour under risk or uncertainty, we introduce reflection lattices. These are complete linear lattices endowed with an order reversing bijection like the reflection at 0 on the real interval $[-1,1]$. Mathematically we investigate the lattice of non-void intervals in a complete linear lattice, then the class of monotone interval-valued functions and their inner product.

  4. Ozonation of tannic acid to model biomass pretreatment for bioethanol production.

    Science.gov (United States)

    Peretz, Roi; Gerchman, Yoram; Mamane, Hadas

    2017-10-01

    Lignocellulosic biomass is a promising feedstock for ethanol production, but lignin, a polyphenol, hampers the use of enzymes for its saccharification; pretreatment is thus key to preparing such feedstock. Ozonation was previously demonstrated as an effective pretreatment, but claimed to be uneconomical due to the assumed need for lignin mineralization. We analyzed, for the first time, ozonation of highly concentrated tannic acid (TA) solution (60g/L) as a lignin model. Most of the TA disappeared within 3.5h, following triple-phase kinetics with two transition points: at 7min and 60min of ozonation for 0.4L ozone reactor. Maximal enzymatic activity was found at the first transition point, demonstrating that very short ozonation that results in partial decomposition of TA, is enough to remediate TA's negative effect on cellulase activity. Short ozonation could decrease energy input by up to 97%, making ethanol production more economically competitive. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Analysis of Ordinal Categorical Data

    CERN Document Server

    Agresti, Alan

    2012-01-01

    Statistical science's first coordinated manual of methods for analyzing ordered categorical data, now fully revised and updated, continues to present applications and case studies in fields as diverse as sociology, public health, ecology, marketing, and pharmacy. Analysis of Ordinal Categorical Data, Second Edition provides an introduction to basic descriptive and inferential methods for categorical data, giving thorough coverage of new developments and recent methods. Special emphasis is placed on interpretation and application of methods including an integrated comparison of the available st

  6. A fault diagnosis methodology for rolling element bearings based on advanced signal pretreatment and autoregressive modelling

    Science.gov (United States)

    Al-Bugharbee, Hussein; Trendafilova, Irina

    2016-05-01

    This study proposes a methodology for rolling element bearings fault diagnosis which gives a complete and highly accurate identification of the faults present. It has two main stages: signals pretreatment, which is based on several signal analysis procedures, and diagnosis, which uses a pattern-recognition process. The first stage is principally based on linear time invariant autoregressive modelling. One of the main contributions of this investigation is the development of a pretreatment signal analysis procedure which subjects the signal to noise cleaning by singular spectrum analysis and then stationarisation by differencing. So the signal is transformed to bring it close to a stationary one, rather than complicating the model to bring it closer to the signal. This type of pretreatment allows the use of a linear time invariant autoregressive model and improves its performance when the original signals are non-stationary. This contribution is at the heart of the proposed method, and the high accuracy of the diagnosis is a result of this procedure. The methodology emphasises the importance of preliminary noise cleaning and stationarisation. And it demonstrates that the information needed for fault identification is contained in the stationary part of the measured signal. The methodology is further validated using three different experimental setups, demonstrating very high accuracy for all of the applications. It is able to correctly classify nearly 100 percent of the faults with regard to their type and size. This high accuracy is the other important contribution of this methodology. Thus, this research suggests a highly accurate methodology for rolling element bearing fault diagnosis which is based on relatively simple procedures. This is also an advantage, as the simplicity of the individual processes ensures easy application and the possibility for automation of the entire process.

  7. Empirical Modeling on Hot Air Drying of Fresh and Pre-treated Pineapples

    Directory of Open Access Journals (Sweden)

    Tanongkankit Yardfon

    2016-01-01

    Full Text Available This research was aimed to study drying kinetics and determine empirical model of fresh pineapple and pre-treated pineapple with sucrose solution at different concentrations during drying. 3 mm thick samples were immersed into 30, 40 and 50 Brix of sucrose solution before hot air drying at temperatures of 60, 70 and 80°C. The empirical models to predict the drying kinetics were investigated. The results showed that the moisture content decreased when increasing the drying temperatures and times. Increase in sucrose concentration led to longer drying time. According to the statistical values of the highest coefficients (R2, the lowest least of chi-square (χ2 and root mean square error (RMSE, Logarithmic model was the best models for describing the drying behavior of soaked samples into 30, 40 and 50 Brix of sucrose solution.

  8. A novel kinetic model for polysaccharide dissolution during atmospheric acetic acid pretreatment of sugarcane bagasse.

    Science.gov (United States)

    Zhao, Xuebing; Morikawa, Yuichi; Qi, Feng; Zeng, Jing; Liu, Dehua

    2014-01-01

    Acetic acid (AcH) pretreatment of sugarcane bagasse with the catalysis of sulfuric acid (SA) could greatly enhance the enzymatic digestibility of cellulose. However, polysaccharide dissolution happened inevitably during the pretreatment. It was found that the simplest model, which assumes that the total polysaccharides were reactive to be dissolved, could not well describe the kinetic behavior of polysaccharide dissolution. A novel pseudo-homogenous kinetic model was thus developed by introducing a parameter termed as "potential dissolution degree" (δ(d)) based on the multilayered structure of cell wall. It was found that solid xylan and glucan dissolutions were a first-order reaction with respect to the dissolvable fraction. Due to the delignification action of AcH, polysaccharide dissolutions were enhanced in AcH media compared with those in aqueous system. Acetylizations of cellulose and sugars were also observed, and AcH concentration showed a significant influence on the degree of acetylization. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Preference score of units in the presence of ordinal data

    Energy Technology Data Exchange (ETDEWEB)

    Jahanshahloo, G.R.; Soleimani-damaneh, M. [Department of Mathematics, Teacher Training University, Tehran (Iran, Islamic Republic of); Mostafaee, A. [Department of Mathematics, North-Tehran Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of)], E-mail: mostafaee_m@yahoo.com

    2009-01-15

    This study deals with the ordinal data in the performance analysis framework and provides a weight-restricted DEA model to obtain the preference score of each unit under assessment. The obtained scores are used to rank DMUs. Furthermore, to decrease the complexity of the provided model, the number of the constraints is decreased by some linear transformations.

  10. Three-Dimensional Radiation in Absorbing -Emitting-Scattering Medium Using the Discrete-Ordinates Approximation

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    The discrete-ordinates method is a simple,accurate and of little computational time solution to predict the radiactive heat transfer in the combustion chambers,In this paper,three-dimension radiative problems for absorbing-emitting-scattering medium are modeled using this method in the rectangular enclosure.And in addition,new discrete-ordinates are developed to study the absorbing-emitting-scattering radiation processes for complex phase function.The reasonable results can be obtained though these new ordinates,yet the deviated results are only obtained through conventional Sn ordinates.

  11. Rectal Adenocarcinoma: Proposal for a Model Based on Pretreatment Prognostic Factors

    Science.gov (United States)

    Cabanillas, Fernando; Freire, Viviana; Nieves-Plaza, Mariely; Quevedo, Gerardo; Echenique, Ignacio A.

    2012-01-01

    Objective Currently the choice of chemotherapy regimen in rectal cancer is made prior to surgery in contrast to colon cancer where it is made postoperatively after the pathological stage has been determined. If we could identify which are the important pretreatment prognostic factors in rectal cancer, we could then target those patients with unfavorable features to investigate potentially more effective preoperative chemotherapy regimens aimed at those with unfavorable features. The present study aims to determine pre-treatment prognostic factors that are associated with an unfavorable outcome. Methods A retrospective review of 99 rectal cancer patients operated at the Hospital Auxilio Mutuo and Hospital San Pablo was done. Sociodemographic characteristics, clinical and treatment data was collected. Results 54% were males. The mean ± sd age was 62.2 ± 10.4. In age-adjusted Cox model, male gender [HR (95%CI): 3.32 (1.09–10.13)], mucinous carcinoma [HR (95%CI): 3.67 (1.25–10.77)], and clinical stages II & III [HR (95%CI): 8.19 (1.08–62.08)] were predictors of poor prognosis. In multivariate age-adjusted analysis, a tendency towards a poorer prognosis was observed for male patients [HR: 2.60] CEA level ≥ 5ng/ml [HR: 2.55], mucinous carcinoma [HR:2.96], and clinical stages II & III [HR:4.96], although results were not statistically significant (p>0.05), Conclusion Although current therapeutic results are relatively favorable with preoperative 5-Fluorouracil (5FU) and radiotherapy, future clinical trials should address the management of those cases with adverse pretreatment prognostic factors so that they can be treated with potentially more effective albeit more toxic chemotherapy regimens. PMID:22783696

  12. Pretreatment of Cisplatin in Recipients Attenuates Post-Transplantation Pancreatitis in Murine Model

    Directory of Open Access Journals (Sweden)

    Sheng Yan, Yuan Ding, Fei Sun, Zhongjie Lu, Liang Xue, Xiangyan Liu, Mingqi Shuai, Chen Fang, Yan Wang, Hui Cheng, Lin Zhou, Ming H Zheng, Shusen Zheng

    2012-01-01

    Full Text Available Pancreas transplantation is the definite treatment for type 1 diabetes that enables the achievement of long-term normoglycemia and insulin independence. However Post-Transplantation Pancreatitis (PTP due to ischemia reperfusion (IR injury and preservation is a major complication in pancreas transplantation. Owning the potential anti-inflammatory effect of Cisplatin (Cis in liver IR injury, we have examined if Cis could attenuate PTP using a murine model. We found that Cis is able to prevent inflammatory response in PTP. Pretreatment of Cis in recipient mice reduce the impairments of the grafts and hyperamylasimea in the recipients. We documented that the protective mechanism of Cis in PTP involves improvement of microcirculation, reduction of the mononuclear cellular infiltration and apoptosis, suppression of inflammatory cytokine-cascade and inhibition of translocation of high-motility group box protein-1 (HMGB-1 from nucleus to cytoplasm. In short, our study demonstrated that pretreatment of Cis in recipients may reduce the onset of PTP in pancreas transplantation.

  13. Kinetic modeling of enzymatic hydrolysis of pretreated kitchen wastes for enhancing bioethanol production.

    Science.gov (United States)

    Cekmecelioglu, Deniz; Uncu, Oya N

    2013-03-01

    It is well known that use of low cost and abundant waste materials in microbial fermentations can reduce product costs. Kitchen wastes disposed of in large amounts from cafeterias, restaurants, dining halls, food processing plants, and household kitchens contain high amounts of carbohydrate components such as glucose, starch, and cellulose. Efficient utilization of these sugars is another opportunity to reduce ethanol costs. In this study, the effect of pretreatment methods (hot water, acid solutions, and a control) on enzymatic hydrolysis of kitchen wastes was evaluated using a kinetic modeling approach. Fermentation experiments conducted with and without traditional fermentation nutrients were assessed at constant conditions of pH 4.5 and temperature of 30°C for 48h using commercial dry baker's yeast, Saccharomyces cerevisiae. The control, which involved no treatment, and hot water treated samples gave close glucose concentrations after 6h. The highest and lowest rates of glucose production were found as 0.644 and 0.128 (h(-1)) for the control (or no-pretreated (NPT)) and 1% acid solutions, respectively. The fermentation results indicated that final ethanol concentrations are not significantly improved by adding nutrients (17.2-23.3g/L). Thus, it was concluded that product cost can be lowered to a large extent if (1) kitchen wastes are used as a substrate, (2) no fermentation nutrient is used, and (3) hydrolysis time is applied for about 6h. Further optimization study is needed to increase the yield to higher levels.

  14. Modeling the improvement of ultrafiltration membrane mass transfer when using biofiltration pretreatment in surface water applications.

    Science.gov (United States)

    Netcher, Andrea C; Duranceau, Steven J

    2016-03-01

    In surface water treatment, ultrafiltration (UF) membranes are widely used because of their ability to supply safe drinking water. Although UF membranes produce high-quality water, their efficiency is limited by fouling. Improving UF filtrate productivity is economically desirable and has been attempted by incorporating sustainable biofiltration processes as pretreatment to UF with varying success. The availability of models that can be applied to describe the effectiveness of biofiltration on membrane mass transfer are lacking. In this work, UF water productivity was empirically modeled as a function of biofilter feed water quality using either a quadratic or Gaussian relationship. UF membrane mass transfer variability was found to be governed by the dimensionless mass ratio between the alkalinity (ALK) and dissolved organic carbon (DOC). UF membrane productivity was optimized when the biofilter feed water ALK to DOC ratio fell between 10 and 14. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Ordinal Boltzmann Machines for Collaborative Filtering

    CERN Document Server

    Truyen, Tran The; Venkatesh, Svetha

    2012-01-01

    Collaborative filtering is an effective recommendation technique wherein the preference of an individual can potentially be predicted based on preferences of other members. Early algorithms often relied on the strong locality in the preference data, that is, it is enough to predict preference of a user on a particular item based on a small subset of other users with similar tastes or of other items with similar properties. More recently, dimensionality reduction techniques have proved to be equally competitive, and these are based on the co-occurrence patterns rather than locality. This paper explores and extends a probabilistic model known as Boltzmann Machine for collaborative filtering tasks. It seamlessly integrates both the similarity and co-occurrence in a principled manner. In particular, we study parameterisation options to deal with the ordinal nature of the preferences, and propose a joint modelling of both the user-based and item-based processes. Experiments on moderate and large-scale movie recomm...

  16. Radiative transfer modelling in combusting systems using discrete ordinates method on three-dimensional unstructured grids; Modelisation des transferts radiatifs en combustion par methode aux ordonnees discretes sur des maillages non structures tridimensionnels

    Energy Technology Data Exchange (ETDEWEB)

    Joseph, D.

    2004-04-01

    The prediction of pollutant species such as soots and NO{sub x} emissions and lifetime of the walls in a combustion chamber is strongly dependant on heat transfer by radiation at high temperatures. This work deals with the development of a code based on the Discrete Ordinates Method (DOM) aiming at providing radiative source terms and wall fluxes with a good compromise between cpu time and accuracy. Radiative heat transfers are calculated using the unstructured grids defined by the Computational Fluid Dynamics (CFD) codes. The spectral properties of the combustion gases are taken into account by a statistical narrow bands correlated-k model (SNB-ck). Various types of angular quadrature are tested and three different spatial differencing schemes were integrated and compared. The validation tests show the limit at strong optical thicknesses of the finite volume approximation used the Discrete Ordinates Method. The first calculations performed on LES solutions are presented, it provides instantaneous radiative source terms and wall heat fluxes. Those results represent a first step towards radiation/combustion coupling. (author)

  17. Biomass pretreatment

    Science.gov (United States)

    Hennessey, Susan Marie; Friend, Julie; Elander, Richard T; Tucker, III, Melvin P

    2013-05-21

    A method is provided for producing an improved pretreated biomass product for use in saccharification followed by fermentation to produce a target chemical that includes removal of saccharification and or fermentation inhibitors from the pretreated biomass product. Specifically, the pretreated biomass product derived from using the present method has fewer inhibitors of saccharification and/or fermentation without a loss in sugar content.

  18. Cable Television Report and Suggested Ordinance.

    Science.gov (United States)

    League of California Cities, Sacramento.

    Guidelines and suggested ordinances for cable television regulation by local governments are comprehensively discussed in this report. The emphasis is placed on franchising the cable operator. Seventeen legal aspects of franchising are reviewed, and an exemplary ordinance is presented. In addition, current statistics about cable franchising in…

  19. Economic Analysis of a Living Wage Ordinance.

    Science.gov (United States)

    Tolley, George; Bernstein, Peter

    A study estimated the costs of the "Chicago Jobs and Living Wage Ordinance" that would require firms that receive assistance from the city of Chicago to pay their workers an hourly wage of at least $7.60. An estimate of the additional labor cost that would result from the proposed Ordinance was calculated. Results of a survey of…

  20. Pretreatment with intraluminal rapamycin nanoparticle perfusion inhibits neointimal hyperplasia in a rabbit vein graft model

    Directory of Open Access Journals (Sweden)

    Kai Liu

    2010-10-01

    Full Text Available Kai Liu1*, Guangqing Cao1*, Xiquan Zhang1, Ruifang Liu2, Weiwei Zou3, Shuming Wu11Departments of Cardiovascular Surgery, 2Anesthesia, Qilu Hospital of Shandong University, Jinan; 3The School of Pharmaceutical Science, Shandong University, Jinan, Shandong, People’s Republic of China; *Kai Liu and Guangqing Cao contributed equally to this work.Purpose: Poly lactic-co-glycolic acid nanoparticles (PLGA-NP are widely used as a biodegradable biomaterial in medicine. Rapamycin-eluting stents have been used for prevention of restenosis during surgery. This study investigated the effect of pretreatment with intraluminal perfusion of carbopol-encapsulated rapamycin-loaded PLGA nanoparticles (RAP-PLGA-NP on neointimal hyperplasia in a rabbit vein graft model.Methods: A segment of common carotid artery was replaced with a segment of external jugular vein in 60 rabbits which were then separated into four treatment groups, ie, Group 1, in which vein grafts were pretreated with intraluminal RAP-PLGA-NP perfusion, Group 2 in which vein grafts underwent equivalent empty vehicle (PLGA-NP perfusion, Group 3, in which vein grafts received no treatment, and Group 4, which served as a sham operation group receiving normal vein contrast. On postoperative day 28, the grafts and normal veins were harvested for histologic examination, flow cytometry analysis, and high-performance liquid chromatography measurement.Results: Compared with Group 1, the intima of the grafts were thickened, the ratio of intimal area to vessel area increased, and the collagen volume index of the vein grafts increased significantly in Groups 2 and 3. The cell proliferation index in Group 1 (21.11 ± 3.15% was much lower than that in Group 2 (30.35 ± 2.69% and in Group 3 (33.86 ± 8.72%. By high-performance liquid chromatography measurement, retention of rapamycin was detected in Group 1 (11.2 ± 0.37 µg/10 mg 28 days after single drug perfusion.Conclusion: Pretreatment with intraluminal RAP

  1. Ordinality and the nature of symbolic numbers.

    Science.gov (United States)

    Lyons, Ian M; Beilock, Sian L

    2013-10-23

    The view that representations of symbolic and nonsymbolic numbers are closely tied to one another is widespread. However, the link between symbolic and nonsymbolic numbers is almost always inferred from cardinal processing tasks. In the current work, we show that considering ordinality instead points to striking differences between symbolic and nonsymbolic numbers. Human behavioral and neural data show that ordinal processing of symbolic numbers (Are three Indo-Arabic numerals in numerical order?) is distinct from symbolic cardinal processing (Which of two numerals represents the greater quantity?) and nonsymbolic number processing (ordinal and cardinal judgments of dot-arrays). Behaviorally, distance-effects were reversed when assessing ordinality in symbolic numbers, but canonical distance-effects were observed for cardinal judgments of symbolic numbers and all nonsymbolic judgments. At the neural level, symbolic number-ordering was the only numerical task that did not show number-specific activity (greater than control) in the intraparietal sulcus. Only activity in left premotor cortex was specifically associated with symbolic number-ordering. For nonsymbolic numbers, activation in cognitive-control areas during ordinal processing and a high degree of overlap between ordinal and cardinal processing networks indicate that nonsymbolic ordinality is assessed via iterative cardinality judgments. This contrasts with a striking lack of neural overlap between ordinal and cardinal judgments anywhere in the brain for symbolic numbers, suggesting that symbolic number processing varies substantially with computational context. Ordinal processing sheds light on key differences between symbolic and nonsymbolic number processing both behaviorally and in the brain. Ordinality may prove important for understanding the power of representing numbers symbolically.

  2. 78 FR 49283 - Chicken Ranch Rancheria-Chicken Ranch Liquor Licensing Ordinance, Ordinance No. 12-10-03

    Science.gov (United States)

    2013-08-13

    ... Bureau of Indian Affairs Chicken Ranch Rancheria--Chicken Ranch Liquor Licensing Ordinance, Ordinance No... the Chicken Ranch Liquor Licensing Ordinance, Ordinance No. 12-10-03. The Ordinance regulates and controls the possession, sale and consumption of liquor within the Indian Country of the Chicken Ranch...

  3. Lime Pretreatment

    Science.gov (United States)

    Sierra, Rocio; Granda, Cesar Benigno; Holtzapple, Mark T.

    Lime pretreatment has proven to be a useful method for selectively reducing the lignin content of lignocellulosic biomass without significant loss in carbohydrates, thus realizing an important increase in biodigestibility. In lime pretreatment, the biomass is pretreated with calcium hydroxide and water under different conditions of temperature and pressure. It can be accomplished in one of three fashions: (1) short-term pretreatment that lasts up to 6 h, requires temperatures of 100-160°C, and can be applied with or without oxygen (pressure ~200 psig); (2) long-term pretreatment taking up to 8 weeks, requiring only 55-65°C, and capable of running with or without air (atmospheric pressure); and (3) simple pretreatment requiring 1 h in boiling water, without air or oxygen. Nonoxidative conditions are effective at low lignin contents (below ~18% lignin), whereas oxidative conditions are required for high lignin contents (above ~18% lignin).

  4. Fuzzy-logic modeling of Fenton's oxidation of anaerobically pretreated poultry manure wastewater.

    Science.gov (United States)

    Yetilmezsoy, Kaan

    2012-07-01

    A multiple inputs and multiple outputs (MIMO) fuzzy-logic-based model was proposed to estimate color and chemical oxygen demand (COD) removal efficiencies in the post-treatment of anaerobically pretreated poultry manure wastewater effluent using Fenton's oxidation process. Three main input variables including initial pH, Fe+2, and H2O2 dosages were fuzzified in a new numerical modeling scheme by the use of an artificial intelligence-based approach. Trapezoidal membership functions with eight levels were conducted for the fuzzy subsets, and a Mamdani-type fuzzy inference system was used to implement a total of 70 rules in the IF-THEN format. The product (prod) and the center of gravity (centroid) methods were applied as the inference operator and defuzzification methods, respectively. Fuzzy-logic predicted results were compared with the outputs of two first-order polynomial regression models derived in the scope of this study. Estimated results were also compared to the multiple regression approach by means of various descriptive statistical indicators, such as root mean-squared error, index of agreement, fractional variance, proportion of systematic error, etc. Results of the statistical analysis clearly revealed that, compared to conventional regression models, the proposed MIMO fuzzy-logic model produced very smaller deviations and demonstrated a superior predictive performance on forecasting of color and COD removal efficiencies with satisfactory determination coefficients over 0.98. Due to high capability of the fuzzy-logic methodology in capturing the non-linear interactions, it was demonstrated that a complex dynamic system, such as Fenton's oxidation, could be easily modeled.

  5. Application of Ordinal Set Pair Analysis in Annual Rainfall Prediction of Liao River Basin

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    [Objective] The research aimed to study the application of ordinal set pair analysis in the annual precipitation prediction of Liao River basin.[Method] The ordinal theory was introduced into the set pair analysis modeling,and the prediction model of set pair analysis was improved.A kind of rainfall prediction model based on the ordinal set pair analysis (OSPA) was put forward.The time sequence of annual rainfall in the hydrological rainfall station of Liao River basin during 1956-2006 was the research obje...

  6. Model‐based approaches to unconstrained ordination

    National Research Council Canada - National Science Library

    Hui, Francis K.C; Taskinen, Sara; Pledger, Shirley; Foster, Scott D; Warton, David I; O'Hara, Robert B

    2015-01-01

    Unconstrained ordination is commonly used in ecology to visualize multivariate data, in particular, to visualize the main trends between different sites in terms of their species composition or relative abundance...

  7. Overview of Existing Wind Energy Ordinances

    Energy Technology Data Exchange (ETDEWEB)

    Oteri, F.

    2008-12-01

    Due to increased energy demand in the United States, rural communities with limited or no experience with wind energy now have the opportunity to become involved in this industry. Communities with good wind resources may be approached by entities with plans to develop the resource. Although these opportunities can create new revenue in the form of construction jobs and land lease payments, they also create a new responsibility on the part of local governments to ensure that ordinances will be established to aid the development of safe facilities that will be embraced by the community. The purpose of this report is to educate and engage state and local governments, as well as policymakers, about existing large wind energy ordinances. These groups will have a collection of examples to utilize when they attempt to draft a new large wind energy ordinance in a town or county without existing ordinances.

  8. Allegheny County Municipal Land Use Ordinances

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Many municipalities have their own land use ordinances and establish standards and requirements for land use and development in that municipality. This dataset is...

  9. GREET Pretreatment Module

    Energy Technology Data Exchange (ETDEWEB)

    Adom, Felix K.; Dunn, Jennifer B.; Han, Jeongwoo

    2014-09-01

    A wide range of biofuels and biochemicals can be produced from biomass via different pretreatment technologies that yield sugars. This report documents the material and energy flows that occur when fermentable sugars from four lignocellulosic feedstocks (corn stover, miscanthus, switchgrass, and poplar) are produced via dilute acid pretreatment and ammonia fiber expansion. These flows are documented for inclusion in the pretreatment module of the Greenhouses Gases, Regulated Emissions, and Energy Use in Transportation (GREET) model. Process simulations of each pretreatment technology were developed in Aspen Plus. Material and energy consumption data from Aspen Plus were then compiled in the GREET pretreatment module. The module estimates the cradle-to-gate fossil energy consumption (FEC) and greenhouse gas (GHG) emissions associated with producing fermentable sugars. This report documents the data and methodology used to develop this module and the cradle-to-gate FEC and GHG emissions that result from producing fermentable sugars.

  10. Biosorption of diazinon by a pre-treated alimentary industrial waste: equilibrium and kinetic modeling

    Science.gov (United States)

    Yeddou Mezenner, N.; Lagha, H.; Kais, H.; Trari, M.

    2017-04-01

    This study explores the feasibility of pre-treated coffee waste (PCW) as biosorbent for the removal of diazinon. The effect of the pesticide concentration (6-20 mg L-1), contact time, adsorbent dose (0.2-1.2 g L-1), solution pH (3-11.5), temperature (15-40 °C) and co-existing inorganic ions (H2PO4 -, NO3 -) on the diazinon biosorption over PCW is investigated. The experimental results indicate an optimal pH of 7.3 for the diazinon elimination on PCW (1 g L-1). The Langmuir model describes well the isotherm data with a high regression coefficient (R 2 > 0.990) and a maximum monolayer biosorption capacity of 18.52 mg g-1 at 15 °C. It is also observed that the intra-particle diffusion is not the rate-controlling step. A comparison is evaluated between the pseudo-second-order and intra-particle diffusion kinetic models; the experimental data are well fitted by the pseudo-second-order kinetic model. The biosorption capacity decreases with increasing temperature for a diazinon concentration of 10 mg L-1. The negative enthalpy ΔH° (-63.57 kJ/mol) indicates that the diazinon biosorption onto PCW is exothermic. Under optimal conditions, the biosorption reaches 95% after 90 min. The removal efficiency decreases from 95 to 65.67 and 48.9% for the diazinon alone and in the presence of NO3 - and H2PO4 - (100 mg L-1), respectively.

  11. Pretreatment with Fish Oil-Based Lipid Emulsion Modulates Muscle Leukocyte Chemotaxis in Murine Model of Sublethal Lower Limb Ischemia

    Science.gov (United States)

    Shih, Yao-Ming; Shih, Juey-Ming; Yeh, Chiu-Li; Li, Cheng-Che

    2017-01-01

    This study investigated the effects of a fish oil- (FO-) based lipid emulsion on muscle leukocyte chemotaxis and inflammatory responses in a murine model of limb ischemia-reperfusion (IR) injury. Mice were assigned randomly to 1 sham (sham) group, 2 ischemic groups, and 2 IR groups. The sham group did not undergo the ischemic procedure. The mice assigned to the ischemic or IR groups were pretreated intraperitoneally with either saline or FO-based lipid emulsion for 3 consecutive days. The IR procedure was induced by applying a 4.5 oz orthodontic rubber band to the left thigh above the greater trochanter for 120 min and then cutting the band to allow reperfusion. The ischemic groups were sacrificed immediately while the IR groups were sacrificed 24 h after reperfusion. Blood, IR-injured gastrocnemius, and lung tissues were collected for analysis. The results showed that FO pretreatment suppressed the local and systemic expression of several IR-induced proinflammatory mediators. Also, the FO-pretreated group had lower blood Ly6ChiCCR2hi monocyte percentage and muscle M1/M2 ratio than the saline group at 24 h after reperfusion. These findings suggest that FO pretreatment may have a protective role in limb IR injury by modulating the expression of proinflammatory mediators and regulating the polarization of macrophage. PMID:28182087

  12. A novel diffusion-biphasic hydrolysis coupled kinetic model for dilute sulfuric acid pretreatment of corn stover.

    Science.gov (United States)

    Chen, Longjian; Zhang, Haiyan; Li, Junbao; Lu, Minsheng; Guo, Xiaomiao; Han, Lujia

    2015-02-01

    Kinetic experiments on the dilute sulfuric acid pretreatment of corn stover were performed. A high xylan removal and a low inhibitor concentration were achieved by acid pretreatment. A novel diffusion-hydrolysis coupled kinetic model was proposed. The contribution to the xylose yield was analyzed by the kinetic model. Compared with the inhibitor furfural negatively affecting xylose yield, the fast and slow-hydrolyzing xylan significantly contributed to the xylose yield, however, their dominant roles were dependent on reaction temperature and time. The impact of particle size and acid concentration on the xylose yield were also investigated. The diffusion process may significantly influence the hydrolysis of large particles. Increasing the acid concentration from 0.15 M to 0.30 M significantly improved the xylose yield, whereas the extent of improvement decreased to near-quantitative when further increasing acid loading. These findings shed some light on the mechanism for dilute sulfuric acid hydrolysis of corn stover.

  13. Regularization for Continuously Observed Ordinal Response Variables with Piecewise-Constant Functional Predictors

    Science.gov (United States)

    2016-01-01

    response variable taking on ordinal values 1 to C and a 1x vector of explanatory variables , , the proportional odds model is given by...I N S T I T U T E F O R D E F E N S E A N A L Y S E S Regularization for Continuously Observed Ordinal Response Variables with Piecewise...response variable , quality of video provided by the Shadow to friendly ground units, was measured on an ordinal scale continuously over time. Functional

  14. Caustic-Side Solvent-Extraction Modeling for Hanford Interim Pretreatment System

    Energy Technology Data Exchange (ETDEWEB)

    Moyer, B.A.; Birdwell, J.F.; Delmau, L. H.; McFarlane, J.

    2008-06-01

    The purpose of this work is to examine the applicability of the Caustic-Side Solvent Extraction (CSSX) process for the removal of cesium from Hanford tank-waste supernatant solutions in support of the Hanford Interim Pretreatment System (IPS). The Hanford waste types are more challenging than those at the Savannah River Site (SRS) in that they contain significantly higher levels of potassium, the chief competing ion in the extraction of cesium. It was confirmed by use of the CSSX model that the higher levels of potassium depress the cesium distribution ratio (DCs), as validated by measurement of DCs values for four of eight specified Hanford waste-simulant compositions. The model predictions were good to an apparent standard error of ±11%. It is concluded from batch distribution experiments, physical-property measurements, equilibrium modeling, flowsheet calculations, and contactor sizing that the CSSX process as currently employed for cesium removal from alkaline salt waste at the SRS is capable of treating similar Hanford tank feeds. For the most challenging waste composition, 41 stages would be required to provide a cesium decontamination factor (DF) of 5000 and a concentration factor (CF) of 5. Commercial contacting equipment with rotor diameters of 10 in. for extraction and 5 in. for stripping should have the capacity to meet throughput requirements, but testing will be required to confirm that the needed efficiency and hydraulic performance are actually obtainable. Markedly improved flowsheet performance was calculated for a new solvent formulation employing the more soluble cesium extractant BEHBCalixC6 used with alternative scrub and strip solutions, respectively 0.1 M NaOH and 10 mM boric acid. The improved system can meet minimum requirements (DF = 5000 and CF = 5) with 17 stages or more ambitious goals (DF = 40,000 and CF = 15) with 19 stages. Potential benefits of further research and development are identified that would lead to reduced costs, greater

  15. Pinatubo Emulation in Multiple Models (POEMs): planned co-ordinated experiments for the SPARC Stratospheric Sulphur and it's Role in Climate initiative (SSiRC)

    Science.gov (United States)

    Mann, Graham; Lee, Lindsay A.; Carslaw, Ken S.; Toohey, Matthew; Aquila, Valentina; Timmreck, Claudia; English, Jason M.; Neely, Ryan R., III

    2014-05-01

    The World Climate Research Program's SPARC initiative has a new international activity "Stratospheric Sulphur and its Role in Climate" (SSiRC) to better understand changes in stratospheric aerosol and precursor gaseous sulphur species. A powerful new technique to quantify and attribute sources of uncertainty in complex global models is described by Lee et al. (2011). This involves "conditioning" a Gaussian emulator to replicate (gridbox by gridbox) the results from an ensemble of runs with the full complex 3D model. Once trained on the ensemble, a Monte Carlo simulation with the fast emulator can be carried out for a full variance-based sensitivity analysis. For example, Carslaw et al., (2013, Nature) used the approach to quantify the uncertainty in indirect aerosol forcing from a 3D global chemistry-aerosol-microphysics model, decomposing the variance attributed to 28 uncertain emissions-types/processes-parameters/model-structures. One component of SSiRC involves an intercomparison of a new generation of Earth System Models that simulate the stratospheric aerosol layer interactively. Following the kick-off meeting for SSiRC in October 2013, one component of the SSiRC activity will be for each model to run "perturbed physics ensembles" (PPEs) of the Pinatubo eruption across several uncertain parameters. The Gaussian emulation approach will the be carried out on each model to characterise and intercompare the magnitude and uncertainty of simulated climate effects. In this poster presentation we will present the overall plan for this "POEMS" analysis including the outcome of an expert elicitation to finalise which uncertain parameters are to be varied and their uncertainty ranges.

  16. Distinguishing Ordinal and Disordinal Interactions

    Science.gov (United States)

    Widaman, Keith F.; Helm, Jonathan L.; Castro-Schilo, Laura; Pluess, Michael; Stallings, Michael C.; Belsky, Jay

    2012-01-01

    Re-parameterized regression models may enable tests of crucial theoretical predictions involving interactive effects of predictors that cannot be tested directly using standard approaches. First, we present a re-parameterized regression model for the Linear x Linear interaction of 2 quantitative predictors that yields point and interval estimates…

  17. Ordinal ultrafilters versus P-hierarchy

    CERN Document Server

    Starosolski, Andrzej

    2012-01-01

    An earlier paper, entitled "P-hierarchy on $\\beta\\omega$", investigated the relations between ordinal ultrafilters and the so-called P-hierarchy. This study is continued in the present paper and focuses on the aspects of characterization of classes of finite index, existence, generic existence and the Rudin-Keisler-order.

  18. Limited memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) method for the parameter estimation on geographically weighted ordinal logistic regression model (GWOLR)

    Science.gov (United States)

    Saputro, Dewi Retno Sari; Widyaningsih, Purnami

    2017-08-01

    In general, the parameter estimation of GWOLR model uses maximum likelihood method, but it constructs a system of nonlinear equations, making it difficult to find the solution. Therefore, an approximate solution is needed. There are two popular numerical methods: the methods of Newton and Quasi-Newton (QN). Newton's method requires large-scale time in executing the computation program since it contains Jacobian matrix (derivative). QN method overcomes the drawback of Newton's method by substituting derivative computation into a function of direct computation. The QN method uses Hessian matrix approach which contains Davidon-Fletcher-Powell (DFP) formula. The Broyden-Fletcher-Goldfarb-Shanno (BFGS) method is categorized as the QN method which has the DFP formula attribute of having positive definite Hessian matrix. The BFGS method requires large memory in executing the program so another algorithm to decrease memory usage is needed, namely Low Memory BFGS (LBFGS). The purpose of this research is to compute the efficiency of the LBFGS method in the iterative and recursive computation of Hessian matrix and its inverse for the GWOLR parameter estimation. In reference to the research findings, we found out that the BFGS and LBFGS methods have arithmetic operation schemes, including O(n2) and O(nm).

  19. Multiple dimensions of health locus of control in a representative population sample: ordinal factor analysis and cross-validation of an existing three and a new four factor model

    Directory of Open Access Journals (Sweden)

    Hapke Ulfert

    2011-08-01

    Full Text Available Abstract Background Based on the general approach of locus of control, health locus of control (HLOC concerns control-beliefs due to illness, sickness and health. HLOC research results provide an improved understanding of health related behaviour and patients' compliance in medical care. HLOC research distinguishes between beliefs due to Internality, Externality powerful Others (POs and Externality Chance. However, evidences for differentiating the POs dimension were found. Previous factor analyses used selected and predominantly clinical samples, while non-clinical studies are rare. The present study is the first analysis of the HLOC structure based on a large representative general population sample providing important information for non-clinical research and public health care. Methods The standardised German questionnaire which assesses HLOC was used in a representative adult general population sample for a region in Northern Germany (N = 4,075. Data analyses used ordinal factor analyses in LISREL and Mplus. Alternative theory-driven models with one to four latent variables were compared using confirmatory factor analysis. Fit indices, chi-square difference tests, residuals and factor loadings were considered for model comparison. Exploratory factor analysis was used for further model development. Results were cross-validated splitting the total sample randomly and using the cross-validation index. Results A model with four latent variables (Internality, Formal Help, Informal Help and Chance best represented the HLOC construct (three-dimensional model: normed chi-square = 9.55; RMSEA = 0.066; CFI = 0.931; SRMR = 0.075; four-dimensional model: normed chi-square = 8.65; RMSEA = 0.062; CFI = 0.940; SRMR = 0.071; chi-square difference test: p Conclusions Future non-clinical HLOC studies in western cultures should consider four dimensions of HLOC: Internality, Formal Help, Informal Help and Chance. However, the standardised German instrument

  20. Processing ordinality and quantity: the case of developmental dyscalculia.

    Science.gov (United States)

    Rubinsten, Orly; Sury, Dana

    2011-01-01

    In contrast to quantity processing, up to date, the nature of ordinality has received little attention from researchers despite the fact that both quantity and ordinality are embodied in numerical information. Here we ask if there are two separate core systems that lie at the foundations of numerical cognition: (1) the traditionally and well accepted numerical magnitude system but also (2) core system for representing ordinal information. We report two novel experiments of ordinal processing that explored the relation between ordinal and numerical information processing in typically developing adults and adults with developmental dyscalculia (DD). Participants made "ordered" or "non-ordered" judgments about 3 groups of dots (non-symbolic numerical stimuli; in Experiment 1) and 3 numbers (symbolic task: Experiment 2). In contrast to previous findings and arguments about quantity deficit in DD participants, when quantity and ordinality are dissociated (as in the current tasks), DD participants exhibited a normal ratio effect in the non-symbolic ordinal task. They did not show, however, the ordinality effect. Ordinality effect in DD appeared only when area and density were randomized, but only in the descending direction. In the symbolic task, the ordinality effect was modulated by ratio and direction in both groups. These findings suggest that there might be two separate cognitive representations of ordinal and quantity information and that linguistic knowledge may facilitate estimation of ordinal information.

  1. Processing ordinality and quantity: the case of developmental dyscalculia.

    Directory of Open Access Journals (Sweden)

    Orly Rubinsten

    Full Text Available In contrast to quantity processing, up to date, the nature of ordinality has received little attention from researchers despite the fact that both quantity and ordinality are embodied in numerical information. Here we ask if there are two separate core systems that lie at the foundations of numerical cognition: (1 the traditionally and well accepted numerical magnitude system but also (2 core system for representing ordinal information. We report two novel experiments of ordinal processing that explored the relation between ordinal and numerical information processing in typically developing adults and adults with developmental dyscalculia (DD. Participants made "ordered" or "non-ordered" judgments about 3 groups of dots (non-symbolic numerical stimuli; in Experiment 1 and 3 numbers (symbolic task: Experiment 2. In contrast to previous findings and arguments about quantity deficit in DD participants, when quantity and ordinality are dissociated (as in the current tasks, DD participants exhibited a normal ratio effect in the non-symbolic ordinal task. They did not show, however, the ordinality effect. Ordinality effect in DD appeared only when area and density were randomized, but only in the descending direction. In the symbolic task, the ordinality effect was modulated by ratio and direction in both groups. These findings suggest that there might be two separate cognitive representations of ordinal and quantity information and that linguistic knowledge may facilitate estimation of ordinal information.

  2. 36 CFR 28.15 - Approval of local zoning ordinances.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Approval of local zoning... INTERIOR FIRE ISLAND NATIONAL SEASHORE: ZONING STANDARDS Federal Standards and Approval of Local Ordinances § 28.15 Approval of local zoning ordinances. (a) The Secretary shall approve local ordinances...

  3. DOS: the discrete-ordinates system. [LMFBR

    Energy Technology Data Exchange (ETDEWEB)

    Rhoades, W. A.; Emmett, M. B.

    1982-09-01

    The Discrete Ordinates System determines the flux of neutrons or photons due either to fixed sources specified by the user or to sources generated by particle interaction with the problem materials. It also determines numerous secondary results which depend upon flux. Criticality searches can be performed. Numerous input, output, and file manipulation facilities are provided. The DOS driver program reads the problem specification from an input file and calls various program modules into execution as specified by the input file.

  4. Projected health impact of the Los Angeles City living wage ordinance.

    Science.gov (United States)

    Cole, Brian L; Shimkhada, Riti; Morgenstern, Hal; Kominski, Gerald; Fielding, Jonathan E; Wu, Sheng

    2005-08-01

    To estimate the relative health effects of the income and health insurance provisions of the Los Angeles City living wage ordinance. About 10 000 employees of city contractors are subject to the Los Angeles City living wage ordinance, which establishes an annually adjusted minimum wage (7.99 US dollars per hour in July 2002) and requires employers to contribute 1.25 US dollars per hour worked towards employees' health insurance, or, if health insurance is not provided, to add this amount to wages. As part of a comprehensive health impact assessment (HIA), we used estimates of the effects of health insurance and income on mortality from the published literature to construct a model to estimate and compare potential reductions in mortality attributable to the increases in wage and changes in health insurance status among workers covered by the Los Angeles City living wage ordinance. The model predicts that the ordinance currently reduces mortality by 1.4 deaths per year per 10,000 workers at a cost of 27.5 million US dollars per death prevented. If the ordinance were modified so that all uninsured workers received health insurance, mortality would be reduced by eight deaths per year per 10,000 workers at a cost of 3.4 million US dollars per death prevented. The health insurance provisions of the ordinance have the potential to benefit the health of covered workers far more cost effectively than the wage provisions of the ordinance. This analytical model can be adapted and used in other health impact assessments of related policy actions that might affect either income or access to health insurance in the affected population.

  5. Efeito do plano amostral em modelo logístico ordinal: uma análise do estado de saúde autorreferido de adultos no Brasil usando a Pesquisa Nacional por Amostra de Domicílios de 2008 Effect of sampling plan on ordinal logistic models: an analysis of self-rated health status among Brazilian adults based on the National Household Sample Survey (PNAD 2008

    Directory of Open Access Journals (Sweden)

    José Rodrigo de Moraes

    2012-05-01

    Full Text Available Estudos que consideram variáveis individuais e ambientais para explicar as diferenças no estado de saúde autorreferido de indivíduos vêm paulatinamente crescendo no Brasil, mas ainda são escassos. Por razões de tempo e custo, muitas pesquisas utilizam planos amostrais complexos que envolvem aspectos (estratificação, conglomeração e pesos amostrais distintos que quando ignorados podem influenciar as medidas de razões de chance e as medidas de precisão das estimativas dos parâmetros de modelos estatísticos. Usando a Pesquisa Nacional por Amostra de Domicílios (PNAD 2008, este artigo avalia o impacto nessas medidas quando não se consideram alguns ou todos os aspectos ao ajustar um modelo logístico ordinal para estabelecer a associação entre o estado de saúde autorreferido de adultos e um conjunto de fatores individuais e ambientais. Observou-se que quando não se considera os três aspectos simultaneamente, ocorrem alterações nas magnitudes das medidas de razões de chance do adulto autorreferir melhor estado de saúde associadas à maioria dos fatores, além de grande subestimação dos erros padrões.Studies that draw on individual and environmental variables to explain differences in self-rated health status have increased gradually in Brazil, but are still limited in number. Due to time and cost issues, many studies use a complex sample design involving features (stratification, clustering, and different sample weights that, when ignored, can influence odds ratios and standard errors in the statistical models. Using the National Household Sample Survey (PNAD 2008, this paper assesses the impact on these measurements when some or all of these features are not taken into account in fitting ordinal logistic models to establish associations between adults' self-rated health and various individual and environmental factors. According to this study, failure to take these three features into account simultaneously led to changes

  6. Effects of salidroside pretreatment on expression of tumor necrosis factor-alpha and permeability of blood brain barrier in rat model of focal cerebralischemia-reperfusion injury.

    Science.gov (United States)

    Han, Tian

    2013-02-01

    To observe changes in expression of tumor necrosis factor (TNF)-alpha and permeability of blood brain barrier after salidroside pretreatment in rats with injury induced by focal cerebralischemia-reperfusion. Forty-five male SD rats were randomly divided into three groups (n=15): control group, ischemia-reperfusion (IR) model group, and salidroside pretreatment group. Before the IR model establishment, the rats in the salidroside pretreatment group were intraperitoneally administered with salidroside at a dose of 24 mg/(kg·d) for 7 d. After 30 min post the last administration, the IR model was induced by occlusion of middle cerebral artery with a filament. After 24 h post the operation, the water content and Evens blue content in the ischemia cerebral hemisphere were determined, and the level of TNF-alpha mRNA was detected by the semi-quantitative RT-PCR. Compared with the IR model group, the salidroside pretreatment group had significantly lower (Psalidroside pretreatment alleviated the focal cerebralischemia-reperfusion injury in the rat model, possibly by decreasing the permeability of blood brain barrier, attenuating brain edema and reducing TNF-alpha expression. Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  7. Effects of salidroside pretreatment on expression of tumor necrosis factor-alpha and permeability of blood brain barrier in rat model of focal cerebralischemia-reperfusion injury

    Institute of Scientific and Technical Information of China (English)

    Tian Han

    2013-01-01

    Objective:To observe changes in expression of tumor necrosis factor(TNF)-alpha and permeability of blood brain barrier after salidroside pretreatment in rats with injury induced by focal cerebralischemia-reperfusion.Methods:Forty-five maleSD rats were randomly divided into three groups(n=15): control group, ischemia-reperfusion(IR) model group, and salidroside pretreatment group.Before theIR model establishment, the rats in the salidroside pretreatment group were intraperitoneally administered with salidroside at a dose of24 mg/(kg•d) for7 d.After30 min post the last administration, theIR model was induced by occlusion of middle cerebral artery with a filament.After24 h post the operation, the water content andEvens blue content in the ischemia cerebral hemisphere were determined, and the level of TNF-alpha mRNA was detected by the semi-quantitativeRT-PCR.Results:Compared with theIR model group, the salidroside pretreatment group had significantly lower(P<0.05) water content andEvens blue content in the ischemia cerebral hemisphere and also had significantly lower(P<0.05) level of TNF-alpha in the ischemic cerebral cortex tissue.Conclusions:The salidroside pretreatment alleviated the focal cerebralischemia-reperfusion injury in the rat model, possibly by decreasing the permeability of blood brain barrier, attenuating brain edema and reducingTNF-alpha expression.

  8. Changes in polyphenol profiles and color composition of freshly fermented model wine due to pulsed electric field, enzymes and thermovinification pretreatments.

    Science.gov (United States)

    El Darra, Nada; Turk, Mohammad F; Ducasse, Marie-Agnès; Grimi, Nabil; Maroun, Richard G; Louka, Nicolas; Vorobiev, Eugène

    2016-03-01

    This work compares the effects of three pretreatments techniques: pulsed electric fields (PEFs), enzymes treatment (ET) and thermovinification (TV) on the improving of extraction of main phenolic compounds, color characteristics (L(∗)a(∗)b(∗)), and composition (copigmentation, non-discolored pigments) of freshly fermented model wine from Cabernet Sauvignon variety. The pretreatments produced differences in the wines, with the color of the freshly fermented model wine obtained from PEF and TV pretreated musts being the most different with an increase of 56% and 62%, respectively, compared to the control, while the color only increased by 22% for ET. At the end of the alcoholic fermentation, the contents of anthocyanins for all the pretreatments were not statistically different. However, for the content of total phenolics and total flavonols, PEF and TV were statistically different, but ET was not statistically different. The contents of flavonols in musts pretreated by PEF and TV were significantly higher comparing to the control. An increase of 48% and 97% was noted respectively, and only 4% for ET. A similar result was observed for the total phenolics with an increase by 18% and 32% respectively for PEF and TV, and only 3% for ET comparing to the control. The results suggest that the higher intensity and the difference of color composition between the control and pretreated freshly fermented model wines were not related only to a higher content of residual native polyphenols in these freshly fermented model wines. Other phenomena such as copigmentation and formation of derived pigments may be favored by these pretreatments.

  9. A case study of co-ordinative decision-making in disaster management.

    Science.gov (United States)

    Smith, W; Dowell, J

    2000-08-01

    A persistent problem in the management of response to disasters is the lack of co-ordination between the various agencies involved. This paper reports a case study of inter-agency co-ordination during the response to a railway accident in the UK. The case study examined two potential sources of difficulty for co-ordination: first, poorly shared mental models; and, second, a possible conflict between the requirements of distributed decision-making and the nature of individual decision-making. Interviews were conducted with six individuals from three response agencies. Analysis of reported events suggested that inter-agency co-ordination suffered through a widespread difficulty in constructing a reflexive shared mental model; that is, a shared mental representation of the distributed decision-making process itself, and its participants. This difficulty may be an inherent problem in the flexible development of temporary multi-agency organizations. The analysis focused on a distributed decision over how to transport casualties from an isolated location to hospital. This decision invoked a technique identified here as the progression of multiple options, which contrasts with both recognition-primed and analytical models of individual decision-making. The progression of multiple options appeared to be an effective technique for dealing with uncertainty, but was a further source of difficulty for inter-agency co-ordination.

  10. Pre-treatment with capsaicin in a rat osteoarthritis model reduces the symptoms of pain and bone damage induced by monosodium iodoacetate.

    NARCIS (Netherlands)

    Kalff, K.M.; ElMouedden, M.; Egmond, J. van; Veening, J.G.; Joosten, L.A.B.; Scheffer, G.J.; Meert, T.F.; Vissers, K.C.P.

    2010-01-01

    A rat model of osteoarthritis was used to investigate the effect of pre-treatment with capsaicin on the symptoms of osteoarthritis induced by the injection of monosodium iodoacetate. This model mimics both histopathology and symptoms associated of human osteoarthritis. Injection of monosodium iodoac

  11. 1,25-Dihydroxyvitamin D3 pretreatment enhances the efficacy of allergen immunotherapy in a mouse allergic asthma model

    Institute of Scientific and Technical Information of China (English)

    MA Jian-xin; XIA Jun-bo; CHENG Xiao-ming; WANG Chang-zheng

    2010-01-01

    Background Allergen-specific immunotherapy can induce immune tolerance to specific allergens by regulating immune status of individuals. However, its clinical application is limited due to individual differences in efficacy among patients and un-confirmed safety. 1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) has been shown to be involved in a variety of physiological processes, including immune response regulation. In the present study we explored the role of 1,25(OH)2D3 pretreatment for immunotherapy.Methods Seventy-five BALB/c mice were randomly divided into five groups (15 mice per group). The mouse allergic asthma model was established by intra-peritoneal injection of ovalbumin (OVA, 10 μg) and aluminium hydroxide (2 mg)as an adjuvant. Intra-peritoneal injection of 50 ng of 1,25(OH)2D3 served as a pretreatment, subcutaneous injection of OVA (100 μg) as an immunotherapy, and 1% OVA inhalation as a challenge. Histopathological analysis was performed on four mice per group. The number of cells and their classification in bronchoalvolar lavage (BAL) fluid were assayed.Levels of serum OVA-specific immunoglobulin E (slgE) and IFN-Y, IL-4, IL-5 and IL-10 in BAL fluid were measured by ELISA.Results After 1,25(OH)2D3 pretreatment, immunotherapy could significantly inhibit the infiltration of inflammatory cells into lung tissues and BAL fluid of mice with allergic asthma when compared with un-treated animals (eosinophils:(7.46±1.34)×104/ml vs. (13.41±1.67)×104/ml, P <0.05). In addition, levels of IL-4 ((36.g1±7.87) pg/ml vs. (43.70±6.42)pg/ml, P >0.05) and IL-5 ((41.97±7.93) pg/ml vs. (60.14±8.35) pg/ml, P <0.05) in BAL fluid and serum slgE ((0.42±0.05)vs. (0.75±0.06) OD units, P <0.05) were profoundly reduced. However, the IL-10 level in BAL fluid was significantly increased ((67.74±6.57) pg/ml vs. (44.62±8.81) pg/ml, P <0.05).Conclusions These results indicated that 1,25(OH)2D3 pretreatment enhanced the inhibitory effects of immunotherapy on allergic

  12. Calculating reliability measures for ordinal data.

    Science.gov (United States)

    Gamsu, C V

    1986-11-01

    Establishing the reliability of measures taken by judges is important in both clinical and research work. Calculating the statistic of choice, the kappa coefficient, unfortunately is not a particularly quick and simple procedure. Two much-needed practical tools have been developed to overcome these difficulties: a comprehensive and easily understood guide to the manual calculation of the most complex form of the kappa coefficient, weighted kappa for ordinal data, has been written; and a computer program to run under CP/M, PC-DOS and MS-DOS has been developed. With simple modification the program will also run on a Sinclair Spectrum home computer.

  13. Ordinal-Measure Based Shape Correspondence

    Directory of Open Access Journals (Sweden)

    Faouzi Alaya Cheikh

    2002-04-01

    Full Text Available We present a novel approach to shape similarity estimation based on distance transformation and ordinal correlation. The proposed method operates in three steps: object alignment, contour to multilevel image transformation, and similarity evaluation. This approach is suitable for use in shape classification, content-based image retrieval and performance evaluation of segmentation algorithms. The two latter applications are addressed in this papers. Simulation results show that in both applications our proposed measure performs quite well in quantifying shape similarity. The scores obtained using this technique reflect well the correspondence between object contours as humans perceive it.

  14. Ordinal Welfare Comparisons with Multiple Discrete Indicators

    DEFF Research Database (Denmark)

    Arndt, Channing; Distante, Roberta; Hussain, M. Azhar;

    We develop an ordinal method for making welfare comparisons between populations with multidimensional discrete well-being indicators observed at the micro level. The approach assumes that, for each well-being indicator, the levels can be ranked from worse to better; however, no assumptions are ma...... another on the basis of available binary indicators by drawing upon linear programming theory. These approaches are applied to household survey data from Vietnam and Mozambique with a focus on child poverty comparisons over time and between regions....

  15. Detecting DIF in Polytomous Items Using MACS, IRT and Ordinal Logistic Regression

    Science.gov (United States)

    Elosua, Paula; Wells, Craig

    2013-01-01

    The purpose of the present study was to compare the Type I error rate and power of two model-based procedures, the mean and covariance structure model (MACS) and the item response theory (IRT), and an observed-score based procedure, ordinal logistic regression, for detecting differential item functioning (DIF) in polytomous items. A simulation…

  16. Kernel conditional ordinal random fields for temporal segmentation of facial action units

    NARCIS (Netherlands)

    Rudovic, Ognjen; Pavlovic, Vladimir; Pantic, Maja

    2012-01-01

    We consider the problem of automated recognition of temporal segments (neutral, onset, apex and offset) of Facial Action Units. To this end, we propose the Laplacian-regularized Kernel Conditional Ordinal Random Field model. In contrast to standard modeling approaches to recognition of AUs’ temporal

  17. Sustained radiosensitization of hypoxic glioma cells after oxygen pretreatment in an animal model of glioblastoma and in vitro models of tumor hypoxia.

    Science.gov (United States)

    Clarke, Ryon H; Moosa, Shayan; Anzivino, Matthew; Wang, Yi; Floyd, Desiree Hunt; Purow, Benjamin W; Lee, Kevin S

    2014-01-01

    Glioblastoma multiforme (GBM) is the most common and lethal form of brain cancer and these tumors are highly resistant to chemo- and radiotherapy. Radioresistance is thought to result from a paucity of molecular oxygen in hypoxic tumor regions, resulting in reduced DNA damage and enhanced cellular defense mechanisms. Efforts to counteract tumor hypoxia during radiotherapy are limited by an attendant increase in the sensitivity of healthy brain tissue to radiation. However, the presence of heightened levels of molecular oxygen during radiotherapy, while conventionally deemed critical for adjuvant oxygen therapy to sensitize hypoxic tumor tissue, might not actually be necessary. We evaluated the concept that pre-treating tumor tissue by transiently elevating tissue oxygenation prior to radiation exposure could increase the efficacy of radiotherapy, even when radiotherapy is administered after the return of tumor tissue oxygen to hypoxic baseline levels. Using nude mice bearing intracranial U87-luciferase xenografts, and in vitro models of tumor hypoxia, the efficacy of oxygen pretreatment for producing radiosensitization was tested. Oxygen-induced radiosensitization of tumor tissue was observed in GBM xenografts, as seen by suppression of tumor growth and increased survival. Additionally, rodent and human glioma cells, and human glioma stem cells, exhibited prolonged enhanced vulnerability to radiation after oxygen pretreatment in vitro, even when radiation was delivered under hypoxic conditions. Over-expression of HIF-1α reduced this radiosensitization, indicating that this effect is mediated, in part, via a change in HIF-1-dependent mechanisms. Importantly, an identical duration of transient hyperoxic exposure does not sensitize normal human astrocytes to radiation in vitro. Taken together, these results indicate that briefly pre-treating tumors with elevated levels of oxygen prior to radiotherapy may represent a means for selectively targeting radiation

  18. Resin Versus Glass Microspheres for (90)Y Transarterial Radioembolization: Comparing Survival in Unresectable Hepatocellular Carcinoma Using Pretreatment Partition Model Dosimetry.

    Science.gov (United States)

    Van Der Gucht, Axel; Jreige, Mario; Denys, Alban; Blanc-Durand, Paul; Boubaker, Ariane; Pomoni, Anastasia; Mitsakis, Periklis; Silva-Monteiro, Marina; Gnesin, Silvano; Lalonde, Marie Nicod; Duran, Rafael; Prior, John O; Schaefer, Niklaus

    2017-08-01

    The aim of this study was to compare survival of patients treated for unresectable hepatocellular carcinoma (uHCC) with (90)Y transarterial radioembolization (TARE) using pretreatment partition model dosimetry (PMD). Methods: We performed a retrospective analysis of prospectively collected data on 77 patients consecutively treated (mean age ± SD, 66.4 ± 12.2 y) for uHCC (36 uninodular, 5 multinodular, 36 diffuse) with (90)Y TARE (41 resin, 36 glass) using pretreatment PMD. Study endpoints were progression-free survival (PFS) and overall survival (OS) assessed by Kaplan-Meier estimates. Several variables including Barcelona Clinic Liver Cancer (BCLC) staging system, tumor size, and serum α-fetoprotein (AFP) level were investigated using Cox proportional hazards regression. Results: The characteristics of 2 groups were comparable with regard to demographic data, comorbidities, Child-Pugh score, BCLC, serum AFP level, and (90)Y global administered activity. The median follow-up time was 7.7 mo (range, 0.4-50.1 mo). Relapse occurred in 44 patients (57%) at a median of 6 mo (range, 0.4-27.9 mo) after (90)Y TARE, and 41 patients (53%) died from tumor progression. Comparison between resin and glass microspheres revealed higher but not statistically significantly PFS and OS rates in the (90)Y resin group than the (90)Y glass group (resin PFS 6.1 mo [95% confidence interval CI, 4.7-7.4] and glass PFS 5 mo [95% CI, 0.9-9.2], P = 0.53; resin OS 7.7 mo [95% CI, 7.2-8.2] and glass OS 7 mo [95% CI 1.6-12.4], P = 0.77). No significant survival difference between both types of (90)Y microspheres was observed in any subgroups of patients with early/intermediate or advanced BCLC stages. Among the variables investigated, Cox analyses showed that only in the glass group, the BCLC staging system and the serum AFP level were associated with PFS (P = 0.04) and OS (P = 0.04). Tumor size was a prognostic factor without significant influence on PFS and OS after (90)Y TARE. Conclusion

  19. Using ordinal partition transition networks to analyze ECG data

    Science.gov (United States)

    Kulp, Christopher W.; Chobot, Jeremy M.; Freitas, Helena R.; Sprechini, Gene D.

    2016-07-01

    Electrocardiogram (ECG) data from patients with a variety of heart conditions are studied using ordinal pattern partition networks. The ordinal pattern partition networks are formed from the ECG time series by symbolizing the data into ordinal patterns. The ordinal patterns form the nodes of the network and edges are defined through the time ordering of the ordinal patterns in the symbolized time series. A network measure, called the mean degree, is computed from each time series-generated network. In addition, the entropy and number of non-occurring ordinal patterns (NFP) is computed for each series. The distribution of mean degrees, entropies, and NFPs for each heart condition studied is compared. A statistically significant difference between healthy patients and several groups of unhealthy patients with varying heart conditions is found for the distributions of the mean degrees, unlike for any of the distributions of the entropies or NFPs.

  20. Incremental Support Vector Learning for Ordinal Regression.

    Science.gov (United States)

    Gu, Bin; Sheng, Victor S; Tay, Keng Yeow; Romano, Walter; Li, Shuo

    2015-07-01

    Support vector ordinal regression (SVOR) is a popular method to tackle ordinal regression problems. However, until now there were no effective algorithms proposed to address incremental SVOR learning due to the complicated formulations of SVOR. Recently, an interesting accurate on-line algorithm was proposed for training ν -support vector classification (ν-SVC), which can handle a quadratic formulation with a pair of equality constraints. In this paper, we first present a modified SVOR formulation based on a sum-of-margins strategy. The formulation has multiple constraints, and each constraint includes a mixture of an equality and an inequality. Then, we extend the accurate on-line ν-SVC algorithm to the modified formulation, and propose an effective incremental SVOR algorithm. The algorithm can handle a quadratic formulation with multiple constraints, where each constraint is constituted of an equality and an inequality. More importantly, it tackles the conflicts between the equality and inequality constraints. We also provide the finite convergence analysis for the algorithm. Numerical experiments on the several benchmark and real-world data sets show that the incremental algorithm can converge to the optimal solution in a finite number of steps, and is faster than the existing batch and incremental SVOR algorithms. Meanwhile, the modified formulation has better accuracy than the existing incremental SVOR algorithm, and is as accurate as the sum-of-margins based formulation of Shashua and Levin.

  1. Butyrate pretreatment attenuates heart depression in a mice model of endotoxin-induced sepsis via anti-inflammation and anti-oxidation.

    Science.gov (United States)

    Wang, Fangyan; Jin, Zengyou; Shen, Kaiyi; Weng, Tingting; Chen, Zhisong; Feng, Jiahui; Zhang, Zhengzheng; Liu, Jiaming; Zhang, Xiaolong; Chu, Maoping

    2017-03-01

    The depressed heart function is the main complication to cause death of septic patients in clinic. It is urgent to find effective interventions for this intractable disease. In this study, we investigated whether butyrate could be protective for heart against sepsis and the underlying mechanism. Mice were randomly divided into three groups. Model group challenged with LPS (30 mg/kg, i.p.) only. Butyrate group received butyrate (200 mg/kg·d) for 3days prior to LPS administration (30 mg/kg). Normal group received saline only. 6h and 12h after LPS administration were chosen for detection the parameters to estimate the effects or mechanism of butyrate pretreatment on heart of sepsis. The data showed that septic heart depression was attenuated by butyrate pretreatment through improvement of heart function depression (Psepsis was significantly alleviated by butyrate pretreatment (P<0.01). As oxidative stress indicators, SOD and CAT activity, and MDA content in heart were deteriorated by LPS challenge, which was noticeably ameliorated by butyrate pretreatment (P<0.01 or P<0.05). In conclusion, pretreatment with butyrate attenuated septic heart depression via anti-inflammation and anti-oxidation. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Conversation, co-ordination and convention: an empirical investigation of how groups establish linguistic conventions.

    Science.gov (United States)

    Garrod, S; Doherty, G

    1994-12-01

    Two experiments are reported which demonstrate the development of co-ordinated description languages in two groups of communicators playing Garrod and Anderson's (1987) maze game. The experiments contrast language co-ordination between speakers who always interact with the same partner (isolated pairs) as compared with speakers who interact with different partners drawn from the same community. Whereas the isolated pairs show higher degrees of inter-speaker convergence than the community pairs at the start of the experiment, the situation reverses by the time they have all played six or more games. The results are discussed at two levels: (1) in terms of Lewis's formal theory of conventions, and (2) in relation to a language processing model which abides by the "output/input co-ordination" principle proposed in Garrod and Anderson (1987).

  3. Non-rigid registration of medical images based on ordinal feature and manifold learning

    Science.gov (United States)

    Li, Qi; Liu, Jin; Zang, Bo

    2015-12-01

    With the rapid development of medical imaging technology, medical image research and application has become a research hotspot. This paper offers a solution to non-rigid registration of medical images based on ordinal feature (OF) and manifold learning. The structural features of medical images are extracted by combining ordinal features with local linear embedding (LLE) to improve the precision and speed of the registration algorithm. A physical model based on manifold learning and optimization search is constructed according to the complicated characteristics of non-rigid registration. The experimental results demonstrate the robustness and applicability of the proposed registration scheme.

  4. Modeling microbial spoilage and quality of gilthead seabream fillets: combined effect of osmotic pretreatment, modified atmosphere packaging, and nisin on shelf life.

    Science.gov (United States)

    Tsironi, Theofania N; Taoukis, Petros S

    2010-05-01

    The objective of the study was the kinetic modeling of the effect of storage temperature on the quality and shelf life of chilled fish, modified atmosphere-packed (MAP), and osmotically pretreated with the addition of nisin as antimicrobial agent. Fresh gilthead seabream (Sparus aurata) fillets were osmotically treated with 50% high dextrose equivalent maltodextrin (DE 47) plus 5% NaCl. Water loss, solid gain, salt content, and water activity were monitored throughout treatment and treatment conditions were selected for the shelf life study. Untreated and osmotically pretreated slices with and without nisin (2 x 10(4) IU/100 g osmotic solution), packed in air or modified atmosphere (50% CO(2)-50% air), and stored at controlled isothermal conditions (0, 5, 10, and 15 degrees C) were studied. Quality assessment and modeling were based on growth of several microbial indices, total volatile nitrogen, trimethylamine nitrogen, lipid oxidation (TBARS), and sensory scoring. Temperature dependence of quality loss rates was modeled by the Arrhenius equation, validated under dynamic conditions. Pretreated samples showed improved quality stability during subsequent refrigerated storage, in terms of microbial growth, chemical changes, and organoleptic degradation. Osmotic pretreatment with the addition of nisin in combination with MAP was the most effective treatment resulting in significant shelf life extension of gilthead seabream fillets (48 days compared to 10 days for the control at 0 degrees C).

  5. Energy-pointwise discrete ordinates transport methods

    Energy Technology Data Exchange (ETDEWEB)

    Williams, M.L.; Asgari, M.; Tashakorri, R.

    1997-06-01

    A very brief description is given of a one-dimensional code, CENTRM, which computes a detailed, space-dependent flux spectrum in a pointwise-energy representation within the resolved resonance range. The code will become a component in the SCALE system to improve computation of self-shielded cross sections, thereby enhancing the accuracy of codes such as KENO. CENTRM uses discrete-ordinates transport theory with an arbitrary angular quadrature order and a Legendre expansion of scattering anisotropy for moderator materials and heavy nuclides. The CENTRM program provides capability to deterministically compute full energy range, space-dependent angular flux spectra, rigorously accounting for resonance fine-structure and scattering anisotropy effects.

  6. An SPSSR -Menu for Ordinal Factor Analysis

    Directory of Open Access Journals (Sweden)

    Mario Basto

    2012-01-01

    Full Text Available Exploratory factor analysis is a widely used statistical technique in the social sciences. It attempts to identify underlying factors that explain the pattern of correlations within a set of observed variables. A statistical software package is needed to perform the calculations. However, there are some limitations with popular statistical software packages, like SPSS. The R programming language is a free software package for statistical and graphical computing. It offers many packages written by contributors from all over the world and programming resources that allow it to overcome the dialog limitations of SPSS. This paper offers an SPSS dialog written in theR programming language with the help of some packages, so that researchers with little or no knowledge in programming, or those who are accustomed to making their calculations based on statistical dialogs, have more options when applying factor analysis to their data and hence can adopt a better approach when dealing with ordinal, Likert-type data.

  7. The possible order L'ordine possibile

    Directory of Open Access Journals (Sweden)

    Francesco Saverio Chesi

    2011-10-01

    Full Text Available

    La questione dell’ordine sembra porsi in termini ineludibili per una riflessione che, muovendo dalla kantiana logica della relazione, sappia cogliere - nel gioco tra Analitica e Dialettica - la portata metafisica del metodo analogico. Nondimeno, la tensione dell’intero arco categoriale verso la modalità porta poi a rifocalizzare la questione stessa come domanda sul nesso tempo, spazio, possibilità.

    The question of order inevitably proposes a reflection aiming at comprehending, from the play between Analytic and Dialectic, the metaphysical significance of the analogical method, the start point being Kant’s logic of relationship. Nevertheless, the tension of the entire categorical arc toward modality leads to refocus the question on the connection among time, space, and possibility.

  8. Biosorption of uranium(VI) from aqueous solutions by Ca-pretreated Cystoseira indica alga: breakthrough curves studies and modeling.

    Science.gov (United States)

    Ghasemi, Morteza; Keshtkar, Ali Reza; Dabbagh, Reza; Jaber Safdari, S

    2011-05-15

    Uranium(VI) biosorption from aqueous solutions containing 60 mg l(-1) metal concentration by Ca-pretreated Cystoseira indica alga was studied in a packed bed column with 1.5 cm internal diameter. The effect of bed height and flow rate on biosorption process was investigated and the experimental breakthrough curves were obtained. Results showed that by increasing the bed height, the breakthrough and exhaustion times increased and the slope of breakthrough curves decreased. Also, it was observed that the controlled-rate step shifted from external to internal mass transfer limitations, as the flow rate increased. The maximum uptake capacity, 318.15 mg g(-1), and total metal removal, 59.32%, were obtained at flow rate of 2.3 ml min(-1) and bed height of 6 cm. The column was regenerated using 0.1M HCl solution and sorption-desorption studies were carried out for three cycles. The obtained results confirmed that reusability of this biosorbent is possible. The results obtained agreed well with the bed depth service time model. In addition, for estimations of the parameters necessary for the design of a large-scale packed bed column, the experimental data were also fitted to the Thomas, Yan and Belter models and were found to agree with the experimental data fairly well.

  9. Biosorption of uranium(VI) from aqueous solutions by Ca-pretreated Cystoseira indica alga: Breakthrough curves studies and modeling

    Energy Technology Data Exchange (ETDEWEB)

    Ghasemi, Morteza [Faculty of Nuclear Engineering, Shahid Beheshti University, Tehran (Iran, Islamic Republic of); Keshtkar, Ali Reza, E-mail: akeshtkar@aeoi.org.ir [Nuclear Fuel Cycle School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of); Dabbagh, Reza [Nuclear Science Research School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of); Jaber Safdari, S. [Nuclear Fuel Cycle School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of)

    2011-05-15

    Uranium(VI) biosorption from aqueous solutions containing 60 mg l{sup -1} metal concentration by Ca-pretreated Cystoseira indica alga was studied in a packed bed column with 1.5 cm internal diameter. The effect of bed height and flow rate on biosorption process was investigated and the experimental breakthrough curves were obtained. Results showed that by increasing the bed height, the breakthrough and exhaustion times increased and the slope of breakthrough curves decreased. Also, it was observed that the controlled-rate step shifted from external to internal mass transfer limitations, as the flow rate increased. The maximum uptake capacity, 318.15 mg g{sup -1}, and total metal removal, 59.32%, were obtained at flow rate of 2.3 ml min{sup -1} and bed height of 6 cm. The column was regenerated using 0.1 M HCl solution and sorption-desorption studies were carried out for three cycles. The obtained results confirmed that reusability of this biosorbent is possible. The results obtained agreed well with the bed depth service time model. In addition, for estimations of the parameters necessary for the design of a large-scale packed bed column, the experimental data were also fitted to the Thomas, Yan and Belter models and were found to agree with the experimental data fairly well.

  10. Un enfoque ordinal para medir la pobreza Poverty: an ordinal approach to measurement

    Directory of Open Access Journals (Sweden)

    Sen Amartya

    1998-12-01

    Full Text Available Este articulo se propone un nuevo indicador de pobreza que evita algunas deficiencias de los indicadores que hoy utilizan. Para deducir el indicador se utiliza un enfoque axiomático. La concepción de bienestar usada para establecer el conjunto de axiomas es ordinal. La información requerida para el nuevo indicador es bastante limitada, lo que permite su utilización practica.The primary aim of this paper is to propose a new measure of poverty, which should avoid some of the shortcomings of the mea sures currently in use. An axiomatic approach is used to derive the measure. The conception of welfare in the axiom set is ordinal. The information required for the new measure is quite limited, permitting practical use.

  11. Enzymatic saccharification of acid pretreated corn stover: Empirical and fractal kinetic modelling.

    Science.gov (United States)

    Wojtusik, Mateusz; Zurita, Mauricio; Villar, Juan C; Ladero, Miguel; Garcia-Ochoa, Felix

    2016-11-01

    Enzymatic hydrolysis of corn stover was studied at agitation speeds from 50 to 500rpm in a stirred tank bioreactor, at high solid concentrations (20% w/w dry solid/suspension), 50°C and 15.5mgprotein·gglucane(-1). Two empirical kinetic models have been fitted to empirical data, namely: a potential model and a fractal one. For the former case, the global order dramatically decreases from 13 to 2 as agitation speed increases, suggesting an increment in the access of enzymes to cellulose in terms of chemisorption followed by hydrolysis. For its part, the fractal kinetic model fits better to data, showing its kinetic constant a constant augmentation with increasing agitation speed up to a constant value at 250rpm and above, when mass transfer limitations are overcome. In contrast, the fractal exponent decreases with rising agitation speed till circa 0.19, suggesting higher accessibility of enzymes to the substrate.

  12. Statistical Optimality in Multipartite Ranking and Ordinal Regression.

    Science.gov (United States)

    Uematsu, Kazuki; Lee, Yoonkyung

    2015-05-01

    Statistical optimality in multipartite ranking is investigated as an extension of bipartite ranking. We consider the optimality of ranking algorithms through minimization of the theoretical risk which combines pairwise ranking errors of ordinal categories with differential ranking costs. The extension shows that for a certain class of convex loss functions including exponential loss, the optimal ranking function can be represented as a ratio of weighted conditional probability of upper categories to lower categories, where the weights are given by the misranking costs. This result also bridges traditional ranking methods such as proportional odds model in statistics with various ranking algorithms in machine learning. Further, the analysis of multipartite ranking with different costs provides a new perspective on non-smooth list-wise ranking measures such as the discounted cumulative gain and preference learning. We illustrate our findings with simulation study and real data analysis.

  13. Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model.

    Science.gov (United States)

    Aumeier, C; Kasdorf, B; Gruber, M; Busse, H; Wiese, C H; Zink, W; Graf, B M; Zausig, Y A

    2014-04-01

    The use of lipid emulsions to reduce cardiac toxicity of local anaesthetics (LAs) has shown success in experimental studies and some clinical cases, and thus has been implemented in clinical practice. However, lipid treatment is usually given after the occurrence of neurological or cardiovascular symptoms of systemic intoxication. The aim of this study was to determine if pretreatment with lipid emulsion reduces cardiac toxicity produced by bupivacaine or mepivacaine. Isolated rat hearts were perfused with or without lipid emulsion (0.25 ml kg(-1) min(-1)) before administration of equipotent doses of bupivacaine (250 µM) or mepivacaine (1000 µM). Haemodynamic parameters and times from start of perfusion LA to a 1 min period of asystole and recovery were determined. Pretreatment with lipid emulsion extended the time until occurrence of asystole and decreased times to recovery in bupivacaine-induced cardiac toxicity but not in mepivacaine-induced cardiac toxicity compared with control. Lipid pretreatment impaired rate-pressure product recovery in mepivacaine-intoxicated hearts. This study confirms that pretreatment with a lipid emulsion reduces cardiac toxicity of LAs. The efficacy of pretreatment with lipid emulsion was LA-dependent, so pharmacokinetic properties, such as lipophilicity, might influence the effects of lipid emulsion pretreatment.

  14. Pretreatment modeling. A technique for reducing children's fear in the dental operatory.

    Science.gov (United States)

    Greenbaum, P E; Melamed, B G

    1988-10-01

    Research on modeling indicates that this technique offers dentists a means of reducing fear in child patients of all ages. As a preventive measure used with children who have had no prior exposure to dental treatment, it can be particularly efficacious. Based on the assumption that much of adult dental avoidance is based on dental fears acquired in childhood treatment, the reduction of children's dental fear would have a positive effect on the individual's tendency to seek out dental health care throughout his or her lifespan. For the dentist, there are also short- and long-term benefits. Dental management of the child is prerequisite to providing good dental care. Pedodontics as a specialty recognizes behavioral management of the child cannot be separated from the quality of the dentist's work. Fear has been identified as an important factor in disruptive behavior of school age children in the dental office. Practicing dentists consider the fearful, disruptive child to be among the most troublesome of problems in their clinical work. The child must cooperate or at least passively comply with the dentist's procedures in order to have the technical work completed. By reducing disruptive patient behavior (crying, screaming children whose peripheral and gross motor movements often make direct contact with the dentist or his equipment) the most unpalatable aspect of pediatric dentistry is minimized. Further, the actual time for treatment becomes shorter rather than longer. Although modeling is not restricted to videotape media, the emergence of current videotape technology provides the practitioner with the means for incorporating patient viewing of prerecorded modeling tapes as part of the usual waiting period. Such a procedure would mean that in the long run, the dentist will spend more time doing dentistry and less in behavioral management tasks.

  15. Leaching Pretreatments for Improving Biomass Quality: Feedstocks, Solvents, and Extraction Modeling

    Science.gov (United States)

    Yu, Chao Wei

    characterized. Among these solvents, 1M HCl improved the corn stover feedstock quality better than other solvents investigated while water worked better for wheat straw. The results show that 1M HCl increased the ash fusion temperature of corn stover from 900 to 1300°C and above 1550°C for water-treated wheat straw. Leachability of each ion extracted from corn stover and wheat straw with different solvents was determined, and the results may be useful in studying the solubility of different elements in a complex ionic solution like leachate. A parallel diffusion model was developed from Fick's second law of diffusion to describe the mass transfer of compounds extracted from biomass to the bulk liquid phase. The model describes two leaching steps with two effective diffusion coefficients, the first step being an initial washing and fast diffusion ( Dfast) followed by a second slower intraparticle diffusion (Dslow). Mass concentration profiles of anions, cations, and sugars leached from wheat straw with water were developed and were used to estimate parameters in the model and for model validation. Results show that Dfast increased as leaching temperature increased while the effects of leaching ratio on Dfast and Dslow were inconclusive. The calculated Dfast and Dslow for leaching ions and sugars from wheat straw did not follow an Arrhenius behavior, suggesting that the effective diffusion coefficients were different depending on batch leaching conditions. In general, the model was able to predict the concentrations of selected anions, cations and total sugars leached from wheat straw with R2 between 0.85 and 0.99 from linear regression analysis of the experimental data versus predicted data. However, the predictability of the model significantly decreased when employing as low a leaching ratio as 15 L/kg due to the high solids concentration of the slurry and resulting inability to apply sufficient agitation. The model tended to overestimate the concentrations of ions in

  16. Antioxidant Pre-Treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis

    Directory of Open Access Journals (Sweden)

    Tomislav Kizivat

    2017-01-01

    Full Text Available Urolithiasis is characterized by the formation and retention of solid crystals within the urinary tract. Kidney stones are mostly composed of calcium oxalate, which predominantly generates free radicals that are toxic to renal tubular cells. The aim of the study is to explore possible effects of antioxidant pre-treatment on inhibition of oxidative stress. Three cell lines were used as in vitro model of urolithiasis: MDCK I, MDCK II and LLC-PK1. Oxidative stress was induced by exposure of cells to sodium oxalate in concentration of 8 mM. In order to prevent oxidative stress, cells were pre-treated with three different concentrations of l-arginine and vitamin E. Oxidative stress was evaluated by determining the expression of superoxide dismutase (SOD, osteopontin (OPN, and by the concentration of glutathione (GSH. In all three cell lines, pre-treatment of antioxidants increased cell survival. Positive correlation of SOD and OPN expression as well as GSH concentration was observed in all groups of cells. Our results indicate that an antioxidant pre-treatment with l-arginine and vitamin E is able to hamper oxalate-induced oxidative stress in kidney epithelial cells and as such could play a role in prevention of urolithiasis.

  17. Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy.

    Science.gov (United States)

    Brouwers, Bas; Pruniau, Vincent P E G; Cauwelier, Elisa J G; Schuit, Frans; Lerut, Evelyne; Ectors, Nadine; Declercq, Jeroen; Creemers, John W M

    2013-09-20

    Streptozotocin (STZ) is widely used as diabetogenic agent in animal models for diabetic nephropathy (DN). However, it is also directly cytotoxic to kidneys, making it difficult to distinguish between DN-related and STZ-induced nephropathy. Therefore, an improved protocol to generate mice for DN studies, with a quick and robust achievement of the diabetic state, without direct kidney toxicity is required. To investigate the mechanism leading to STZ-induced nephropathy, kidney damage was induced with a high dose of STZ. This resulted in delayed gastric emptying, at least partially caused by impaired desacyl ghrelin clearance. STZ uptake in the kidneys is to a large extent mediated by the sodium/glucose cotransporters (Sglts) because the Sglt inhibitor phlorizin could reduce STZ uptake in the kidneys. Consequently, the direct toxic effects in the kidney and the gastric dilatation were resolved without interfering with the β-cell toxicity. Furthermore, pancreatic STZ uptake was increased, hereby decreasing the threshold for β-cell toxicity, allowing for single low non-nephrotoxic STZ doses (70 mg/kg). In conclusion, this study provides novel insights into the mechanism of STZ toxicity in kidneys and suggests a more efficient regime to induce DN with little or no toxic side effects.

  18. Modeling of radiant heat transfers in non-grey gases using the discrete ordinate method in association with a narrow bands statistical model; Modelisation des transferts radiatifs dans des gaz non gris par la methode des ordonnees discretes associee a un modele statistique a bandes etroites

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, A.B. de; Delmas, A.; Sacadura, J.F. [Institut National des Sciences Appliquees (INSA), 69 - Villeurbanne (France)

    1996-12-31

    A formulation based on the use of the discrete ordinate method applied to the integral form of the radiant heat transfer equation is proposed for non-grey gases. The correlations between transmittances are neglected and no explicit wall reflexion is considered. The configuration analyzed consists in a flat layer of non-isothermal steam-nitrogen mixture. Cavity walls are grey with diffuse reflexion and emission. A narrow band statistical model is used to represent the radiative properties of the gas. The distribution of the radiative source term inside the cavity is calculated along two temperature profiles in a uniform steam concentration. Results obtained using this simplified approach are in good agreement with those found in the literature for the same temperature and concentration distributions. This preliminary study seems to indicate that the algorithm based on the integration of radiant heat transfer along the luminance path is less sensitive to de-correlation effects than formulations based on the differential form the the radiant heat transfer. Thus, a more systematic study of the influence of the neglecting of correlations on the integral approach is analyzed in this work. (J.S.) 16 refs.

  19. Steam pretreatment for coal liquefaction

    Science.gov (United States)

    Ivanenko, Olga

    The objectives of this work are to test the application of steam pretreatment to direct coal liquefaction, to investigate the reaction of model compounds with water, and to explore the use of zeolites in these processes. Previous work demonstrated the effectiveness of steam pretreatment in a subsequent flash pyrolysis. Apparently, subcritical steam ruptures nearly all of the ether cross links, leaving a partially depolymerized structure. It was postulated that very rapid heating of the pretreated coal to liquefaction conditions would be required to preserve the effects of such treatment. Accordingly, a method was adopted in which coal slurry is injected into a hot autoclave containing solvent. Since oxygen is capable of destroying the pretreatment effect, precautions were taken for its rigorous exclusion. Tests were conducted with Illinois No. 6 coal steam treated at 340sp°C, 750 psia for 15 minutes. Both raw and pretreated samples were liquified in deoxygenated tetralin at high severity (400sp°C, 30 min.) and low severity (a: 350sp°C, 30 min., and b: 385sp°C, 15 min.) conditions under 1500 psia hydrogen. Substantial improvement in liquid product quality was obtained and the need for rapid heating and oxygen exclusion demonstrated. Under low severity conditions, the oil yield was more than doubled, going from 12.5 to 29 wt%. Also chemistry of the pretreatment process was studied using aromatic ethers as model compounds. alpha-Benzylnaphthyl ether (alpha-BNE), alpha-naphthylmethyl phenyl (alpha-NMPE), and 9-phenoxyphenanthrene were exposed to steam and inert gas at pretreatment conditions and in some cases to liquid water at 315sp°C. alpha-BNE and alpha-NMPE showed little difference in conversion in inert gas and in steam. Hence, these compounds are poor models for coal in steam pretreatment. Thermally stable 9-phenoxyphenanthrene, however, was completely converted in one hour by liquid water at 315sp°C. At pretreatment conditions mostly rearranged starting

  20. Emission model for landfills with mechanically-biologically pretreated waste, with the emphasis on modelling the gas balance; Emissionsprognosemodell fuer Deponien mit mechanisch-biologisch vorbehandelten Abfaellen - Schwerpunkt: Modellierung des Gashaushaltes

    Energy Technology Data Exchange (ETDEWEB)

    Danhamer, H.

    2001-07-01

    The objective of this work was to determine influence factors on processes going on in landfills with mechanically-biologically pretreated waste (MBP-landfills) in order to predict emissions. For this purpose a computer based model has been developed. The model allows to simulate the gas, water and heat balance as well as settlement processes and was called DESIM2005 (version MB). It is based on theoretical modeling approaches as well as data from lab and reactor experiments. The main focus of model application was to determine factors influencing the gas phase and the emissions of landfill gas and methane during operation and aftercare of MBP-landfills. By performing simulations the effects of changing parameters for the processes gas transport and biological degradation as well as the effects of different qualities in waste pretreatment and of varying landfill operation techniques were investigated. Possibilities for increasing the environmental sustainability of landfills containing mechanically-biologically pretreated waste were shown. (orig.)

  1. A new prognostic model for cancer-specific survival after radical cystectomy including pretreatment thrombocytosis and standard pathological risk factors.

    Science.gov (United States)

    Todenhöfer, Tilman; Renninger, Markus; Schwentner, Christian; Stenzl, Arnulf; Gakis, Georgios

    2012-12-01

    -5 (high risk) was 81.0%, 54.8% and 8.2%, respectively (P thrombocytosis at radical cystectomy portends unfavourable prognosis. •  We constructed a simple weighted prognostic model for cancer-specific outcomes after radical cystectomy based on pretreatment platelet count and established pathological risk factors. •  These data warrant external validation and may allow for tailored monitoring and selection of appropriate patients for neoadjuvant and adjuvant trials. © 2012 BJU INTERNATIONAL.

  2. A model-based 3D patient-specific pre-treatment QA method for VMAT using the EPID

    Science.gov (United States)

    McCowan, P. M.; Asuni, G.; van Beek, T.; van Uytven, E.; Kujanpaa, K.; McCurdy, B. M. C.

    2017-02-01

    This study reports the development and validation of a model-based, 3D patient dose reconstruction method for pre-treatment quality assurance using EPID images. The method is also investigated for sensitivity to potential MLC delivery errors. Each cine-mode EPID image acquired during plan delivery was processed using a previously developed back-projection dose reconstruction model providing a 3D dose estimate on the CT simulation data. Validation was carried out using 24 SBRT-VMAT patient plans by comparing: (1) ion chamber point dose measurements in a solid water phantom, (2) the treatment planning system (TPS) predicted 3D dose to the EPID reconstructed 3D dose in a solid water phantom, and (3) the TPS predicted 3D dose to the EPID and our forward predicted reconstructed 3D dose in the patient (CT data). AAA and AcurosXB were used for TPS predictions. Dose distributions were compared using 3%/3 mm (95% tolerance) and 2%/2 mm (90% tolerance) γ-tests in the planning target volume (PTV) and 20% dose volumes. The average percentage point dose differences between the ion chamber and the EPID, AcurosXB, and AAA were 0.73  ±  1.25%, 0.38  ±  0.96% and 1.06  ±  1.34% respectively. For the patient (CT) dose comparisons, seven (3%/3 mm) and nine (2%/2 mm) plans failed the EPID versus AAA. All plans passed the EPID versus Acuros XB and the EPID versus forward model γ-comparisons. Four types of MLC sensitive errors (opening, shifting, stuck, and retracting), of varying magnitude (0.2, 0.5, 1.0, 2.0 mm), were introduced into six different SBRT-VMAT plans. γ-comparisons of the erroneous EPID dose and original predicted dose were carried out using the same criteria as above. For all plans, the sensitivity testing using a 3%/3 mm γ-test in the PTV successfully determined MLC errors on the order of 1.0 mm, except for the single leaf retraction-type error. A 2%/2 mm criteria produced similar results with two more additional detected

  3. Application of ordinal logistic regression analysis in determining risk factors of child malnutrition in Bangladesh

    OpenAIRE

    Das Sumonkanti; Rahman Rajwanur M

    2011-01-01

    Abstract Background The study attempts to develop an ordinal logistic regression (OLR) model to identify the determinants of child malnutrition instead of developing traditional binary logistic regression (BLR) model using the data of Bangladesh Demographic and Health Survey 2004. Methods Based on weight-for-age anthropometric index (Z-score) child nutrition status is categorized into three groups-severely undernourished (< -3.0), moderately undernourished (-3.0 to -2.01) and nourished (≥-2.0...

  4. Implementation of Palm Print Biometric Identification System Using Ordinal Measures

    Directory of Open Access Journals (Sweden)

    V.K. Narendira Kumar

    2013-11-01

    Full Text Available Personal identification is one of the most important requirements in all e-commerce and criminal detection applications. In this framework, a novel palm print representation method, namely orthogonal line ordinal features, is proposed. The palm print registration, feature extraction, palm print verification and palm print recognition modules are designed to manage the palm prints and the palm print database module is designed to store their palm prints and the person details in the database. The feature extraction module is proposed to extract the ordinal measurements for the palm prints. The verification module is designed to verify the palm print with the personal identification record. The recognition module is proposed to find out the relevant person associated with the palm print image. The proposed palm print recognition scheme uses the intensity and brightness to measure the ordinal measurement. The ordinal measures are estimated for the 4 x 4 regions of the palm print images.

  5. Overstatement in happiness reporting with ordinal, bounded scale.

    Science.gov (United States)

    Tanaka, Saori C; Yamada, Katsunori; Kitada, Ryo; Tanaka, Satoshi; Sugawara, Sho K; Ohtake, Fumio; Sadato, Norihiro

    2016-02-18

    There are various methods by which people can express subjective evaluations quantitatively. For example, happiness can be measured on a scale from 1 to 10, and has been suggested as a measure of economic policy. However, there is resistance to these types of measurement from economists, who often regard welfare to be a cardinal, unbounded quantity. It is unclear whether there are differences between subjective evaluation reported on ordinal, bounded scales and on cardinal, unbounded scales. To answer this question, we developed functional magnetic resonance imaging experimental tasks for reporting happiness from monetary gain and the perception of visual stimulus. Subjects tended to report higher values when they used ordinal scales instead of cardinal scales. There were differences in neural activation between ordinal and cardinal reporting scales. The posterior parietal area showed greater activation when subjects used an ordinal scale instead of a cardinal scale. Importantly, the striatum exhibited greater activation when asked to report happiness on an ordinal scale than when asked to report on a cardinal scale. The finding that ordinal (bounded) scales are associated with higher reported happiness and greater activation in the reward system shows that overstatement bias in happiness data must be considered.

  6. Pinatubo Emulation in Multiple Models (POEMs): co-ordinated experiments in the ISA-MIP model intercomparison activity component of the SPARC Stratospheric Sulphur and it's Role in Climate initiative (SSiRC)

    Science.gov (United States)

    Lee, Lindsay; Mann, Graham; Carslaw, Ken; Toohey, Matthew; Aquila, Valentina

    2016-04-01

    The World Climate Research Program's SPARC initiative has a new international activity "Stratospheric Sulphur and its Role in Climate" (SSiRC) to better understand changes in stratospheric aerosol and precursor gaseous sulphur species. One component of SSiRC involves an intercomparison "ISA-MIP" of composition-climate models that simulate the stratospheric aerosol layer interactively. Within PoEMS each modelling group will run a "perturbed physics ensemble" (PPE) of interactive stratospheric aerosol (ISA) simulations of the Pinatubo eruption, varying several uncertain parameters associated with the eruption's SO2 emissions and model processes. A powerful new technique to quantify and attribute sources of uncertainty in complex global models is described by Lee et al. (2011, ACP). The analysis uses Gaussian emulation to derive a probability density function (pdf) of predicted quantities, essentially interpolating the PPE results in multi-dimensional parameter space. Once trained on the ensemble, a Monte Carlo simulation with the fast Gaussian emulator enabling a full variance-based sensitivity analysis. The approach has already been used effectively by Carslaw et al., (2013, Nature) to quantify the uncertainty in the cloud albedo effect forcing from a 3D global aerosol-microphysics model allowing to compare the sensitivy of different predicted quantities to uncertainties in natural and anthropogenic emissions types, and structural parameters in the models. Within ISA-MIP, each group will carry out a PPE of runs, with the subsequent analysis with the emulator assessing the uncertainty in the volcanic forcings predicted by each model. In this poster presentation we will give an outline of the "PoEMS" analysis, describing the uncertain parameters to be varied and the relevance to further understanding differences identified in previous international stratospheric aerosol assessments.

  7. Satellite Constellation Configuration Design with Rapid Performance Calculation and Ordinal Optimization

    Institute of Scientific and Technical Information of China (English)

    CUI Hongzheng; HAN Chao

    2011-01-01

    Satellite constellation configuration design is a complicated and time-consuming simulation optimization problem.In this paper,a new method called the rapid method for satellite constellation performance calculation is developed by the Hermite interpolation technique to reduce the computing complication and time.The constellation configuration optimization model is established on the basis of the rapid performance calculation.To reduce the search space and enhance the optimization efficiency,this paper presents a new constellation optimization strategy based on the ordinal optimization(00)theory and expands the algorithm realization for constellation optimization including precise and crude models,ordered performance curves,selection rules and selected subsets.Two experiments about navigation constellation and space based surveillance system(SBSS)are carried out and the analysis of simulation results indicates that the ordinal optimization for satellite constellation configuration design is effective.

  8. Constrained Ordination Analysis with Enrichment of Bell-Shaped Response Functions.

    Science.gov (United States)

    Zhang, Yingjie; Thas, Olivier

    2016-01-01

    Constrained ordination methods aims at finding an environmental gradient along which the species abundances are maximally separated. The species response functions, which describe the expected abundance as a function of the environmental score, are according to the ecological fundamental niche theory only meaningful if they are bell-shaped. Many classical model-based ordination methods, however, use quadratic regression models without imposing the bell-shape and thus allowing for meaningless U-shaped response functions. The analysis output (e.g. a biplot) may therefore be potentially misleading and the conclusions are prone to errors. In this paper we present a log-likelihood ratio criterion with a penalisation term to enforce more bell-shaped response shapes. We report the results of a simulation study and apply our method to metagenomics data from microbial ecology.

  9. 25 CFR 522.8 - Publication of class III ordinance and approval.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Publication of class III ordinance and approval. 522.8... AND CLASS III ORDINANCES AND RESOLUTIONS SUBMISSION OF GAMING ORDINANCE OR RESOLUTION § 522.8 Publication of class III ordinance and approval. The Chairman shall publish a class III tribal...

  10. 25 CFR 522.6 - Approval requirements for class III ordinances.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Approval requirements for class III ordinances. 522.6... AND CLASS III ORDINANCES AND RESOLUTIONS SUBMISSION OF GAMING ORDINANCE OR RESOLUTION § 522.6 Approval requirements for class III ordinances. No later than 90 days after the submission to the Chairman under §...

  11. Estimation of health benefits from a local living wage ordinance.

    Science.gov (United States)

    Bhatia, R; Katz, M

    2001-09-01

    This study estimated the magnitude of health improvements resulting from a proposed living wage ordinance in San Francisco. Published observational models of the relationship of income to health were applied to predict improvements in health outcomes associated with proposed wage increases in San Francisco. With adoption of a living wage of $11.00 per hour, we predict decreases in premature death from all causes for adults aged 24 to 44 years working full-time in families whose current annual income is $20,000 (for men, relative hazard [RH] = 0.94, 95% confidence interval [CI] = 0.92, 0.97; for women, RH = 0.96, 95% CI = 0.95, 0.98). Improvements in subjectively rated health and reductions in the number of days sick in bed, in limitations of work and activities of daily living, and in depressive symptoms were also predicted, as were increases in daily alcohol consumption. For the offspring of full-time workers currently earning $20,000, a living wage predicts an increase of 0.25 years (95% CI = 0.20, 0.30) of completed education, increased odds of completing high school (odds ratio = 1.34, 95% CI = 1.20, 1.49), and a reduced risk of early childbirth (RH = 0.78, 95% CI = 0.69, 0.86). A living wage in San Francisco is associated with substantial health improvement.

  12. Using missing ordinal patterns to detect nonlinearity in time series data

    Science.gov (United States)

    Kulp, Christopher W.; Zunino, Luciano; Osborne, Thomas; Zawadzki, Brianna

    2017-08-01

    The number of missing ordinal patterns (NMP) is the number of ordinal patterns that do not appear in a series after it has been symbolized using the Bandt and Pompe methodology. In this paper, the NMP is demonstrated as a test for nonlinearity using a surrogate framework in order to see if the NMP for a series is statistically different from the NMP of iterative amplitude adjusted Fourier transform (IAAFT) surrogates. It is found that the NMP works well as a test statistic for nonlinearity, even in the cases of very short time series. Both model and experimental time series are used to demonstrate the efficacy of the NMP as a test for nonlinearity.

  13. Insulation co-ordination and the enlargement law for the GM counter tube

    Directory of Open Access Journals (Sweden)

    Dolićanin Edin Ć.

    2016-01-01

    Full Text Available In this paper we analyze application of contemporary methods of insulation co-ordination and the enlargement law in designing a GM counting tube. It has been shown that by applying insulation co-ordination methods the counting tube can be optimally dimensioned. The application of the enlargement law was demonstrated in generalizing the results of test obtained by the GM tube to those obtained by the counting tube with m-times greater dimensions. The investigations were conducted both theoretically and by experiment. Using theoretical analysis, we derived the expressions that may be applied if a performance function of a random variable breakdown voltage is known. The experiments were conducted on a GM counter model under well controlled laboratory conditions.

  14. Node ordinal encoded genetic algorithm for the optimal allocation of water resources

    Institute of Scientific and Technical Information of China (English)

    YANG Xiaohua; YANG Zhifeng; SHEN Zhenyao; LI Jianqiang

    2005-01-01

    A new method, node ordinal encoded genetic algorithm (NOEGA), is proposed for solving water resources optimal allocation problems, in which the capacity of water resources is split into a number of smaller parts so that successive operations can be overlapped. Our objective is to maximize the whole benefit function. To overcome the "dimensionality and algorithm complexity curse" while searching for solutions and looking for an optimal solution, the operations of one-point crossover operator, gene exchange operator, gene random operator, gene shift operator and node ordinal strings are established. It is proved to be an effective optimal method in searching for global solutions. The NOEGA does not need a diversity of initial population, and it does not have the problem of immature convergence. The results of two cases show that using NOEGA to solve the optimal allocation model is very efficient and robust. In addition, the algorithm complexity of NOEGA is discussed.

  15. Continuous anaerobic digestion of swine manure: ADM1-based modelling and effect of addition of swine manure fibers pretreated with aqueous ammonia soaking

    DEFF Research Database (Denmark)

    Jurado, E.; Antonopoulou, G.; Lyberatos, G.

    2016-01-01

    (ADM1) was fitted to a manure-fed, CSTR-type digester and validated by simulating the performance of a second reactor digesting manure. It was shown that disintegration and hydrolysis of the solid matter of manure was such a slow process that the organic particulate matter did not significantly...... contribute to the methane production. In the second place, ADM1 was used to describe biogas production from the codigestion of manure and AAS pretreated manure fibers. The model predictions regarding biogas production and methane content were in good agreement with the experimental data. It was shown that...

  16. Co-ordination Action on Ocean Energy (CA-OE)

    DEFF Research Database (Denmark)

    Tedd, James; Frigaard, Peter

    In October 2004, the Co-ordination Action on Ocean Energy (CA-OE) was launched, co-financed by the European Commission, under the Renewable Energy Technologies priority within the 6th Framework programme, contract number 502701, chaired by Kim Nielsen, Rambøll, Denmark. The project involves 41...... partners. In general the public is not aware of the development of ocean energy and its exploitation. There is a need to make a united effort from the developers and research community to present the various principles and results in a coordinated manner with public appeal. The main objectives of the Co......-ordination Action on Ocean Energy are: To develop a common knowledge base necessary for coherent research and development policiesTo bring a co-ordinated approach within key areas of ocean energy research and development.To provide a forum for the longer term marketing of promising research developments...

  17. Co-ordination Action on Ocean Energy (CA-OE)

    DEFF Research Database (Denmark)

    Tedd, James; Frigaard, Peter

    In October 2004, the Co-ordination Action on Ocean Energy (CA-OE) was launched, co-financed by the European Commission, under the Renewable Energy Technologies priority within the 6th Framework programme, contract number 502701, chaired by Kim Nielsen, Rambøll, Denmark. The project involves 41...... partners. In general the public is not aware of the development of ocean energy and its exploitation. There is a need to make a united effort from the developers and research community to present the various principles and results in a coordinated manner with public appeal. The main objectives of the Co......-ordination Action on Ocean Energy are: To develop a common knowledge base necessary for coherent research and development policiesTo bring a co-ordinated approach within key areas of ocean energy research and development.To provide a forum for the longer term marketing of promising research developments...

  18. An Ordination of the Vegetation of Ntshongweni, Natal*

    Directory of Open Access Journals (Sweden)

    J. W. Morris

    1969-12-01

    Full Text Available The physiography, soils, climate and dense woody vegetation are briefly described for Ntshongweni, a cone-shaped hill in Natal, South Africa (29° 51' S and 30° 43' E. A primary ordination of the woody plants, based on Bray & Curtis’s (1957 method, was carried out using 60 quadrats. Four stand noda were delimited and another four noda within a secondary ordination of a cluster of quadrats which could not be interpreted within the primary ordination. Edaphic and atmospheric moisture conditions and slope aspect were proposed as the main site factors correlated with species performance. Tables of density, local frequency and constancy for species occurring in each nodum were drawn up.

  19. Methods for pretreating biomass

    Science.gov (United States)

    Balan, Venkatesh; Dale, Bruce E; Chundawat, Shishir; Sousa, Leonardo

    2017-05-09

    A method for pretreating biomass is provided, which includes, in a reactor, allowing gaseous ammonia to condense on the biomass and react with water present in the biomass to produce pretreated biomass, wherein reactivity of polysaccharides in the biomass is increased during subsequent biological conversion as compared to the reactivity of polysaccharides in biomass which has not been pretreated. A method for pretreating biomass with a liquid ammonia and recovering the liquid ammonia is also provided. Related systems which include a biochemical or biofuel production facility are also disclosed.

  20. In vivo pretreatment of Eudrilus eugeniae powder attenuates β-adrenoceptor toxicity mediated by isoproterenol in rat model

    Directory of Open Access Journals (Sweden)

    Jaganathan Anitha

    2016-08-01

    Full Text Available The present study was designed to discover the potential cardioprotective function of earthworm powder (EWP extracted from Eudrilus eugeniae on isoproterenol (ISO-induced myocardial infarction in male Wistar rats. The rats were divided into four groups, with six rats in each group. Certain rats were pretreated with EWP (200 mg/kg bwt (Group III, and a myocardial infarction was then induced by subcutaneous injection of ISO (85 mg/kg bwt (Group II. Oral pretreatment of 200 mg/kg bwt of EWP for 28 days significantly (p > 0.05 improved the blood profile levels, including (a the lipid profile of total cholesterol (TC, free fatty acids (FFA, and triglycerides (TG; (b low-density lipoprotein (LDL, very low-density lipoprotein (VLDL, high-density lipoprotein (HDL, and protein; and (c A/G ratio, glucose and uric acid levels. The electrophoretic pattern of elevated lactose dehydrogenase (LDH levels was recovered by EWP treatment as evidenced by comparison with ISO-induced rats with cardiac damage. The above results indicate that EWP (200 mg/kg bwt provides a cardioprotective effect by attenuating the blood profile, lipid profile, biochemical levels, and LDH patterns in rats that experienced an ISO-induced myocardial infarction.

  1. Ordinal pattern statistics for the assessment of heart rate variability

    Science.gov (United States)

    Graff, G.; Graff, B.; Kaczkowska, A.; Makowiec, D.; Amigó, J. M.; Piskorski, J.; Narkiewicz, K.; Guzik, P.

    2013-06-01

    The recognition of all main features of a healthy heart rhythm (the so-called sinus rhythm) is still one of the biggest challenges in contemporary cardiology. Recently the interesting physiological phenomenon of heart rate asymmetry has been observed. This phenomenon is related to unbalanced contributions of heart rate decelerations and accelerations to heart rate variability. In this paper we apply methods based on the concept of ordinal pattern to the analysis of electrocardiograms (inter-peak intervals) of healthy subjects in the supine position. This way we observe new regularities of the heart rhythm related to the distribution of ordinal patterns of lengths 3 and 4.

  2. Open Method of Co-Ordination for Demoi-Cracy?

    DEFF Research Database (Denmark)

    Borrás, Susana; Radaelli, Claudio

    2014-01-01

    Under which conditions does the open method of co-ordination match the standards for demoi-cracy? To answer this question, we need some explicit standards about demoi-cracy. In fact, open co-ordination serves three different but interrelated purposes in European Union policy: to facilitate...... considering the empirical evidence on how normative principles hit the road of implementation. In the final part of this paper, we look into the demoi-cratic effects of the Eurozone's economic and financial crisis on our findings....

  3. Projected discrete ordinates methods for numerical transport problems

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, E.W.

    1985-01-01

    A class of Projected Discrete-Ordinates (PDO) methods is described for obtaining iterative solutions of discrete-ordinates problems with convergence rates comparable to those observed using Diffusion Synthetic Acceleration (DSA). The spatially discretized PDO solutions are generally not equal to the DSA solutions, but unlike DSA, which requires great care in the use of spatial discretizations to preserve stability, the PDO solutions remain stable and rapidly convergent with essentially arbitrary spatial discretizations. Numerical results are presented which illustrate the rapid convergence and the accuracy of solutions obtained using PDO methods with commonplace differencing methods.

  4. Water model experimental of dephosphorization pretreatment in converter%转炉铁水脱磷预处理水模试验

    Institute of Scientific and Technical Information of China (English)

    杨文远; 李林; 彭小艳; 王明林; 高飞; 吴鸿祚

    2015-01-01

    利用1/9有机玻璃模型测定了脱磷预处理转炉在不同喷吹条件下的熔池混匀时间、顶吹射流对熔池的穿透深度,渣-钢之间的乳化率。研究了废钢在脱磷预处理转炉熔池中的运动状况,测量了不同单重的废钢在熔池中的悬浮能量。为深入了解转炉脱磷预处理的工艺特点,和转炉正常炼钢的相应数值进行了对比。根据水模测定结果,对A炉、B炉2个脱磷预处理情况进行了比较。从总体情况看,A炉的操作比较合理,预处理后的铁水中磷质量分数可降低到0.010%~0.015%,相当于日本和歌山钢厂的水平。%Mixing time in bath,top blowing jet penetrating depth and emulsification rate between slag and molten steel were measured under different blowing conditions in 1/9 plexiglass model. Scrap movement status in dephosphorization pretreatment bath was studied. Suspension energy of different weight scrap in the bath was measured. To better understand the characteristics of dephosphorization pretreatment process,all the values were compared with normal steelmaking con-verter correspondingly. A and B two kinds of dephosphorization pretreatment conditions were compared according to the measurement results of water model. From the overall situation,the operation of A convert is more reasonable,phospho-rus content after pretreatment in hot metal can be reduced to 0.010%-0.015%,be equivalent to the level of Japan's Wakayama Steel Plant.

  5. Roadside Judgments in Children with Developmental Co-ordination Disorder

    Science.gov (United States)

    Purcell, Catherine; Wann, John P.; Wilmut, Kate; Poulter, Damian

    2011-01-01

    As pedestrians, the perceptual ability to accurately judge the relative rate of approaching vehicles and select a suitable crossing gap requires sensitivity to looming. It also requires that crossing judgments are synchronized with motoric capabilities. Previous research has suggested that children with Developmental Co-ordination Disorder (DCD)…

  6. Analog Magnitudes Support Large Number Ordinal Judgments in Infancy.

    Science.gov (United States)

    vanMarle, Kristy; Mou, Yi; Seok, Jin H

    2016-01-01

    Few studies have explored the source of infants' ordinal knowledge, and those that have are equivocal regarding the underlying representational system. The present study sought clear evidence that the approximate number system, which underlies children's cardinal knowledge, may also support ordinal knowledge in infancy; 10 - to 12-month-old infants' were tested with large sets (>3) in an ordinal choice task in which they were asked to choose between two hidden sets of food items. The difficulty of the comparison varied as a function of the ratio between the sets. Infants reliably chose the greater quantity when the sets differed by a 2:3 ratio (4v6 and 6v9), but not when they differed by a 3:4 ratio (6v8) or a 7:8 ratio (7v8). This discrimination function is consistent with previous studies testing the precision of number and time representations in infants of roughly this same age, thus providing evidence that the approximate number system can support ordinal judgments in infancy. The findings are discussed in light of recent proposals that different mechanisms underlie infants' reasoning about small and large numbers.

  7. 32 CFR 510.1 - Private ministrations, sacraments, and ordinances.

    Science.gov (United States)

    2010-07-01

    ... ordinances. Chaplains will conduct or arrange for appropriate burial services at the interment of members of... may perform the marriage rite, provided he complies with the civil law of the place where the marriage.... Chaplains will administer or arrange for rites and sacraments for military personnel and civilians...

  8. When Can Information from Ordinal Scale Variables Be Integrated?

    Science.gov (United States)

    Kemp, Simon; Grace, Randolph C.

    2010-01-01

    Many theoretical constructs of interest to psychologists are multidimensional and derive from the integration of several input variables. We show that input variables that are measured on ordinal scales cannot be combined to produce a stable weakly ordered output variable that allows trading off the input variables. Instead a partial order is…

  9. Indoor smoking ordinances in workplaces and public places in Kansas.

    Science.gov (United States)

    Neuberger, John S; Davis, Ken; Nazir, Niaman; Dunton, Nancy; Winn, Kimberly; Jacquot, Sandy; Moler, Don

    2010-08-01

    The purpose of this study was to investigate the preferences of elected city officials regarding the need for a statewide clean indoor air law and to analyze the content of local smoking ordinances. A survey of elected officials in 57 larger Kansas cities obtained information on the perceived need for statewide legislation, venues to be covered, and motivating factors. Clean indoor air ordinances from all Kansas cities were analyzed by venue. The survey response rate was 190 out of 377 (50.4%) for elected officials. Over 70% of the respondents favored or strongly favored greater restrictions on indoor smoking. Sixty percent favored statewide legislation. Among these, over 80% favored restrictions in health care facilities, theaters, indoor sports arenas (including bowling alleys), restaurants, shopping malls, lobbies, enclosed spaces in outdoor arenas, and hotel/motel rooms. Officials who had never smoked favored a more restrictive approach. Employee and public health concerns were cited as influential by 76%-79% of respondents. Thirty-eight ordinances, covering over half of the state's population, were examined. They varied considerably in their exemptions. Official's attitudes toward smoking regulations were associated with their smoking status. The examination of existing ordinances revealed a piecemeal approach to smoking regulations.

  10. Exploiting Monotonicity Constraints in Active Learning for Ordinal Classification

    NARCIS (Netherlands)

    Soons, Pieter; Feelders, Adrianus

    2014-01-01

    We consider ordinal classication and instance ranking problems where each attribute is known to have an increasing or decreasing relation with the class label or rank. For example, it stands to reason that the number of query terms occurring in a document has a positive in uence on its relevance to

  11. The anti-Manichaean theodicy of Augustine's De ordine

    African Journals Online (AJOL)

    2013-04-10

    Apr 10, 2013 ... Therese Fuhrer. Email: therese.fuhrer@fu-berlin.de. Postal address: Institut für ... Milan, I have selected De ordine for my study for two reasons. Firstly, in this ..... reflections and to perceive the rule-governed character of the.

  12. Carbonic Acid Pretreatment of Biomass

    Energy Technology Data Exchange (ETDEWEB)

    G. Peter van Walsum; Kemantha Jayawardhana; Damon Yourchisin; Robert McWilliams; Vanessa Castleberry

    2003-05-31

    acid compared to water alone. 6) Determine optimal conditions for carbonic acid pretreatment of aspen wood. Optimal severities appeared to be in the mid range tested. ASPEN-Plus modeling and economic analysis of the process indicate that the process could be cost competitive with sulfuric acid if the concentration of solids in the pretreatment is maintained very high (~50%). Lower solids concentrations result in larger reactors that become expensive to construct for high pressure applications.

  13. Comparison of multidimensional fuzzy set ordination with CCA and DB-RDA.

    Science.gov (United States)

    Roberts, David W

    2009-09-01

    Multidimensional fuzzy set ordination (MFSO) is an ordination algorithm based on the principles of fuzzy set theory that employs a dissimilarity matrix and environmental or experimental variables directly in the calculation of ordination coordinates. The objective is similar to constrained ordinations such as canonical correspondence analysis (CCA) and distance-based redundancy analysis (DB-RDA), although MFSO employs a different conceptual and algorithmic basis. Results from MFSO, CCA, and DB-RDA are compared on four data sets to determine the relative ability of the methods to identify and quantify environmental variable effect sizes on community variability. Models were fit by best all-subsets solutions and tested for significance by permutation tests. Methods were compared on the basis of variables selected and dimensionality of results and were evaluated on the basis of the correlation of the pair-wise distances of the derived ordination solutions to a Bray-Curtis dissimilarity matrix of the taxon data, and by cross-comparisons of the inertia explained by the fitted or derived values substituted into DB-RDA and CCA analyses. MFSO and DB-RDA achieved the highest correlation with the Bray-Curtis dissimilarity matrix on one data set each, and they tied for highest correlation on the two other data sets (differences set, tied for second on another, and achieved the lowest correlation on two data sets. When substituting MFSO- and DB-RDA-derived values into CCA, MFSO results achieved higher inertia explained on two of the four data sets; MFSO and DB-RDA achieved equivalent results on the other two. Substituting MFSO- or CCA-derived or fitted values into DB-RDA, MFSO results achieved higher inertia explained on all four data sets. While goodness-of-fit statistics were often similar across methods, the methods sometimes chose solutions of different dimensionality or employed different variables. In general, all algorithms performed well, finding relatively low

  14. Effect of Shen-Fu Injection Pretreatment to Myocardial Metabolism During Untreated Ventricular Fibrillation in a Porcine Model

    Institute of Scientific and Technical Information of China (English)

    Wei Yuan; Jun-Yuan Wu; Guo-Xing Wang; Qian Zhang; Chun-Sheng Li

    2015-01-01

    Background: Shen-Fu injection (SFI) can attenuate ischemia-reperfusion injury, protect cardiac function, and improve microcirculation during cardiopulmonary resuscitation.We hypothesized that SFI may also have an influence on myocardial metabolism during ventricular fibrillation (VF).In this study, we used SFI pretreatment prior to VF to discuss the changes of myocardial metabolism and catecholamine (CA) levels during untreated VF, trying to provide new evidence to the protection of SFI to myocardium.Methods: Twenty-four pigs were divided into three groups: Saline group (SA group), SFI group, and SHAM operation group (SHAM group).Thirty minutes prior to the induction of VF, the SFI group received 0.24 mg/ml SFI through an intravenous injection;the SA group received an equal amount of sodium chloride solution.The interstitial fluid from the left ventricle (LV) wall was collected through the microdialysis tubes during VF.Adenosine diphosphate (ADP), adenosine triphosphate (ATP), and Na+-K+-ATPase and Ca2+-ATPase enzyme activities were measured after untreated VF.Peak-to-trough VF amplitude and median frequency were analyzed for each of these 5-s intervals.Results: The levels of glucose and glutamate were lower after VF in both the SA and SFI groups, compared with baseline, and the levels in the SFI group were higher than those in the SA group.Compared with baseline, the levels of lactate and the lactate/pyruvate ratio increased after VF in both SA and SFI groups, and the levels in the SFI group were lower than those in the SA group.In both the SA and SFI groups, the levels of dopamine, norepinephrine, and epinephrine increased significantly.There were no statistical differences between the two groups.The content ofATP, ADP, and phosphocreatine in the SFI group was higher than those in the SA group.The activity of LV Na+-K+-ATPase was significantly higher in the SFI group than in the SA group.Amplitude mean spectrum area (AMSA) was significantly lower in the SA and

  15. Lime pretreatment of lignocellulosic biomass

    Science.gov (United States)

    Chang, Shushien

    Lignocellulose is a valuable alternative energy source. The susceptibility of lignocellulosic biomass to enzymatic hydrolysis is constrained due to its structural features, so pretreatment is essential to enhance enzymatic digestibility. Of the chemicals used as pretreatment agents, it has been reported that alkalis improve biomass digestibility significantly. In comparison with other alkalis such as NaOH and ammonia, lime (calcium hydroxide) has many advantages; it is very inexpensive, is safe, and can be recovered by carbonating wash water. The effects of lime pretreatment were explored on switchgrass and poplar wood, representing herbaceous and woody biomass, respectively. The effects of pretreatment conditions (time, temperature, lime loading, water loading, particle size, and oxygen pressure) have been systematically studies. Lime alone enhances the digestibility of switchgrass significantly; under the recommended conditions, the 3-d total sugar (glucose + xylose) yields of lime-treated switchgrass were 7 times that of untreated sample. When treating poplar wood, lime must be combined with oxygen to achieve high digestibility; oxidative lime pretreatment increased the 3-d total sugar yield of poplar wood to 12 times that of untreated sample. In a fundamental study, to determine why lime pretreatment is effective, the effects of three structural features on enzymatic digestibility were studied: lignin content, acetyl content, and crystallinity index (CrI). Poplar wood was treated with peracetic acid, potassium hydroxide, and ball milling to produce model lignocelluloses with a broad spectrum of lignin contents, acetyl contents, and CrI, respectively. Enzymatic hydrolysis was performed on the model lignocelluloses to determine the digestibility. Correlations between lignin/carbohydrate ratio, acetyl/carbohydrate ratio, CrI and digestibility were developed. The 95% prediction intervals show that the correlations predict the 1-h and 3-d total sugar conversions of

  16. A Comparison of Imputation Strategies for Ordinal Missing Data on Likert Scale Variables.

    Science.gov (United States)

    Wu, Wei; Jia, Fan; Enders, Craig

    2015-01-01

    This article compares a variety of imputation strategies for ordinal missing data on Likert scale variables (number of categories = 2, 3, 5, or 7) in recovering reliability coefficients, mean scale scores, and regression coefficients of predicting one scale score from another. The examined strategies include imputing using normal data models with naïve rounding/without rounding, using latent variable models, and using categorical data models such as discriminant analysis and binary logistic regression (for dichotomous data only), multinomial and proportional odds logistic regression (for polytomous data only). The result suggests that both the normal model approach without rounding and the latent variable model approach perform well for either dichotomous or polytomous data regardless of sample size, missing data proportion, and asymmetry of item distributions. The discriminant analysis approach also performs well for dichotomous data. Naïvely rounding normal imputations or using logistic regression models to impute ordinal data are not recommended as they can potentially lead to substantial bias in all or some of the parameters.

  17. 77 FR 10547 - Kickapoo Traditional Tribe of Texas-First Amended Beer and Liquor Tax Ordinance

    Science.gov (United States)

    2012-02-22

    ... among other things, beer, ale, stout, lager beer, porter and other malt or brewed liquors. (8) ``Liquor... Bureau of Indian Affairs Kickapoo Traditional Tribe of Texas--First Amended Beer and Liquor Tax Ordinance... to the Kickapoo Traditional Tribe of Texas' Beer and Liquor Tax Ordinance. The Ordinance regulates...

  18. 25 CFR 522.7 - Disapproval of a class III ordinance.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Disapproval of a class III ordinance. 522.7 Section 522.7 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR APPROVAL OF CLASS II AND CLASS III ORDINANCES AND RESOLUTIONS SUBMISSION OF GAMING ORDINANCE OR RESOLUTION § 522.7 Disapproval of a class...

  19. Canoco reference manual and user's guide: software for ordination, version 5.0

    NARCIS (Netherlands)

    Braak, ter C.J.F.; Smilauer, P.

    2012-01-01

    Canoco is a software package for multivariate data analysis, with an emphasis on dimesional reduction (ordination), regression analysis, and the combination of the two, constrained ordination. Canoco makes effective and powerful ordination methods easilyt accessible for scientists wanting to infer a

  20. An Ordinal Index on the Space of Strictly Singular Operators

    CERN Document Server

    Beanland, Kevin

    2009-01-01

    Using the notion of $S_\\xi$-strictly singular operator introduced by Androulakis, Dodos, Sirotkin and Troitsky, we define an ordinal index on the subspace of strictly singular operators between two separable Banach spaces. In our main result, we provide a sufficient condition implying that this index is bounded by $\\omega_1$. In particular, we apply this result to study operators on totally incomparable spaces, hereditarily indecomposable spaces and spaces with few operators.

  1. Co-ordination in the autonomous software agents’ systems

    Directory of Open Access Journals (Sweden)

    J. Madejski

    2012-11-01

    Full Text Available Purpose: Agents are designed to behave individually rational, which means that they should maximize their personal utility which is the way to make them less vulnerable to mean actions of others, yet they have to co-ordinate their actions to reach common goals, which is the purpose of this work.Design/methodology/approach: Agents can create and pursue their individual goals, behaving in a ‘selfish’ way to acquire the desired state of their world. To achieve that they may choose to adopt goals of other agents too, should this co-ordination be assessed as beneficial for them. Moreover, there is also a possibility to define the desired states of the agents in a way which will induce them to work together rather than try to operate individually. This may include their specialization, which forces in most cases sharing of their potential. This may be achieved by specialised design of agents being able to carry out elementary tasks. Such approach calls however, for design of a layer of supervisory agents which will be capable of realising what is the multi-agent overall system goal, setting up their teams from simple agents and committing to common sub-goals. All such systems may be efficiently developed only after careful study of the successfully operating systems in which humans are the agents, whose tasks may now be assigned to the software ones. These agents have to be coupled, as it also happens in their human counterparts.Findings: Development of the software agents’ co-operation framework based on review of publications covering both the fundamental considerations, as well as the latest developments.Research limitations/implications: Approach presented still needs careful testing and refinement of theco-ordination / negotiation rules.Originality/value: Co-ordination of agents to reach their common goal, satisfying also their individual utility

  2. Human Age Estimation Based on Locality and Ordinal Information.

    Science.gov (United States)

    Li, Changsheng; Liu, Qingshan; Dong, Weishan; Zhu, Xiaobin; Liu, Jing; Lu, Hanqing

    2015-11-01

    In this paper, we propose a novel feature selection-based method for facial age estimation. The face aging is a typical temporal process, and facial images should have certain ordinal patterns in the aging feature space. From the geometrical perspective, a facial image can be usually seen as sampled from a low-dimensional manifold embedded in the original high-dimensional feature space. Thus, we first measure the energy of each feature in preserving the underlying local structure information and the ordinal information of the facial images, respectively, and then we intend to learn a low-dimensional aging representation that can maximally preserve both kinds of information. To further improve the performance, we try to eliminate the redundant local information and ordinal information as much as possible by minimizing nonlinear correlation and rank correlation among features. Finally, we formulate all these issues into a unified optimization problem, which is similar to linear discriminant analysis in format. Since it is expensive to collect the labeled facial aging images in practice, we extend the proposed supervised method to a semi-supervised learning mode including the semi-supervised feature selection method and the semi-supervised age prediction algorithm. Extensive experiments are conducted on the FACES dataset, the Images of Groups dataset, and the FG-NET aging dataset to show the power of the proposed algorithms, compared to the state-of-the-arts.

  3. Exploring Local and Overall Ordinal Information for Robust Feature Description.

    Science.gov (United States)

    Wang, Zhenhua; Fan, Bin; Wang, Gang; Wu, Fuchao

    2016-11-01

    This paper aims to build robust feature descriptors by exploring intensity order information in a patch. To this end, the local intensity order pattern (LIOP) and the overall intensity order pattern (OIOP) are proposed to effectively encode intensity order information of each pixel in different aspects. Specifically, LIOP captures the local ordinal information by using the intensity relationships among all the neighbouring sampling points around a pixel, while OIOP exploits the coarsely quantized overall intensity order of these sampling points. These two kinds of patterns are then separately aggregated into different ordinal bins, leading to two kinds of feature descriptors. Furthermore, as these two kinds of descriptors could encode complementary ordinal information, they are combined together to obtain a discriminative and compact mixed intensity order pattern descriptor. All these descriptors are constructed on the basis of relative relationships of intensities in a rotationally invariant way, making them be inherently invariant to image rotation and any monotonic intensity changes. Experimental results on image matching and object recognition are encouraging, demonstrating the superiorities of our descriptors over the state of the art.

  4. On analyzing ordinal data when responses and covariates are both missing at random.

    Science.gov (United States)

    Rana, Subrata; Roy, Surupa; Das, Kalyan

    2016-08-01

    In many occasions, particularly in biomedical studies, data are unavailable for some responses and covariates. This leads to biased inference in the analysis when a substantial proportion of responses or a covariate or both are missing. Except a few situations, methods for missing data have earlier been considered either for missing response or for missing covariates, but comparatively little attention has been directed to account for both missing responses and missing covariates, which is partly attributable to complexity in modeling and computation. This seems to be important as the precise impact of substantial missing data depends on the association between two missing data processes as well. The real difficulty arises when the responses are ordinal by nature. We develop a joint model to take into account simultaneously the association between the ordinal response variable and covariates and also that between the missing data indicators. Such a complex model has been analyzed here by using the Markov chain Monte Carlo approach and also by the Monte Carlo relative likelihood approach. Their performance on estimating the model parameters in finite samples have been looked into. We illustrate the application of these two methods using data from an orthodontic study. Analysis of such data provides some interesting information on human habit.

  5. Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model.

    Science.gov (United States)

    Zellinger, Christina; Salvamoser, Josephine D; Soerensen, Jonna; van Vliet, Erwin A; Aronica, Eleonora; Gorter, Jan; Potschka, Heidrun

    2014-05-01

    The glycine co-agonist binding site of the N-methyl-D-aspartat (NMDA) receptor is discussed as an interesting target for different central nervous system diseases. Antagonism at this co-agonist site has been suggested as an alternative to the use of non-competitive or competitive NMDA receptor antagonists, which are associated with a pronounced adverse effect profile in chronic epilepsy models and epilepsy patients. In the present study, we addressed the hypothesis that sub-chronic administration of the glycine-binding site antagonist L-701,324 might exert disease-modifying effects in fully kindled mice during a period with frequent seizure elicitation (massive kindling). Moreover, we analyzed whether L-701,324 exposure during this phase affects the subsequent response to an antiepileptic drug. L-701,324 treatment during the massive kindling phase did not affect ictogenesis. Mean seizure severity and cumulative seizure duration proved to be comparable between vehicle- and L-701,324-treated mice. Following withdrawal of L-701,324 seizure thresholds did not differ in a significant manner from those in animals that received vehicle injections. A low dosage of phenobarbital caused a significant increase of the generalized seizure threshold in the L-701,324 pre-treated group, whereas it did not exert a comparable effect in animals that received vehicle during the massive kindling phase. Analysis of P-glycoprotein in the hilus of the hippocampus revealed lower expression rates in L-701,324 pre-treated kindled mice. In conclusion, the data indicate that targeting of the NMDA receptor glycine-binding site does not result in anticonvulsant or disease-modifying effects. However, it might improve antiepileptic drug responses. The findings might be linked to an impact on P-glycoprotein expression. However, future studies are necessary to further evaluate the mechanisms and assess the potential of respective add-on approaches.

  6. Developing a User Reported Measure of Care Co-ordination

    Directory of Open Access Journals (Sweden)

    Helen Crump

    2017-03-01

    Full Text Available Introduction: Older people with chronic conditions often receive poor care because of the fragmented way in which their services are delivered from multiple sources. Providers have limited tools to directly capture the views of older people about their experiences of care co-ordination. The study aim was to design and test a survey tool to capture the experiences of older people with chronic conditions regarding how well their health and (where applicable social care was co-ordinated. Method: To inform the questionnaire development, we reviewed the literature on existing surveys and care co-ordination theory, and on the health status of our target audience (people aged 65 or over with one or more chronic conditions and not in hospital or residential institutions. We also consulted stakeholders including those working in health and social care services and those with expertise in the subject area. We grouped questions around experiences of care in three dimensions: care in the home environment, planned transitions in care and unplanned situations. We also designed the questions so they could be mapped onto three recognised dimensions of continuity of care – management continuity, information continuity and relational continuity – as articulated in the international literature. The questionnaire was tested using focus groups and cognitive interviews and piloted with people aged 65 and over with at least one chronic condition, using a postal survey. We used service user records in 32 general practices located in four areas and a population database held by one local authority in England as the sampling frame. Results: The pilot achieved an overall response rate of 27.6% (n = 562 responses. Ninety five percent of respondents answered 30 or more of the 46 questions and three respondents answered fewer than 10 questions. Twenty four items achieved one or more positive correlations greater than 0.5 with other survey items and four instances of

  7. Application of ordinal logistic regression analysis in determining risk factors of child malnutrition in Bangladesh

    Directory of Open Access Journals (Sweden)

    Das Sumonkanti

    2011-11-01

    Full Text Available Abstract Background The study attempts to develop an ordinal logistic regression (OLR model to identify the determinants of child malnutrition instead of developing traditional binary logistic regression (BLR model using the data of Bangladesh Demographic and Health Survey 2004. Methods Based on weight-for-age anthropometric index (Z-score child nutrition status is categorized into three groups-severely undernourished ( Results All the models determine that age of child, birth interval, mothers' education, maternal nutrition, household wealth status, child feeding index, and incidence of fever, ARI & diarrhoea were the significant predictors of child malnutrition; however, results of PPOM were more precise than those of other models. Conclusion These findings clearly justify that OLR models (POM and PPOM are appropriate to find predictors of malnutrition instead of BLR models.

  8. A coupled ordinates method for solution acceleration of rarefied gas dynamics simulations

    Science.gov (United States)

    Das, Shankhadeep; Mathur, Sanjay R.; Alexeenko, Alina; Murthy, Jayathi Y.

    2015-05-01

    Non-equilibrium rarefied flows are frequently encountered in a wide range of applications, including atmospheric re-entry vehicles, vacuum technology, and microscale devices. Rarefied flows at the microscale can be effectively modeled using the ellipsoidal statistical Bhatnagar-Gross-Krook (ESBGK) form of the Boltzmann kinetic equation. Numerical solutions of these equations are often based on the finite volume method (FVM) in physical space and the discrete ordinates method in velocity space. However, existing solvers use a sequential solution procedure wherein the velocity distribution functions are implicitly coupled in physical space, but are solved sequentially in velocity space. This leads to explicit coupling of the distribution function values in velocity space and slows down convergence in systems with low Knudsen numbers. Furthermore, this also makes it difficult to solve multiscale problems or problems in which there is a large range of Knudsen numbers. In this paper, we extend the coupled ordinates method (COMET), previously developed to study participating radiative heat transfer, to solve the ESBGK equations. In this method, at each cell in the physical domain, distribution function values for all velocity ordinates are solved simultaneously. This coupled solution is used as a relaxation sweep in a geometric multigrid method in the spatial domain. Enhancements to COMET to account for the non-linearity of the ESBGK equations, as well as the coupled implementation of boundary conditions, are presented. The methodology works well with arbitrary convex polyhedral meshes, and is shown to give significantly faster solutions than the conventional sequential solution procedure. Acceleration factors of 5-9 are obtained for low to moderate Knudsen numbers on single processor platforms.

  9. GREET Pretreatment Module

    Energy Technology Data Exchange (ETDEWEB)

    Adom, Felix K. [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division; Dunn, Jennifer B. [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division; Han, Jeongwoo [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division

    2014-09-01

    A wide range of biofuels and biochemicals can be produced from cellulosic biomass via different pretreatment technologies that yield sugars. Process simulations of dilute acid and ammonia fiber expansion pretreatment processes and subsequent hydrolysis were developed in Aspen Plus for four lignocellulosic feedstocks (corn stover, miscanthus, switchgrass, and poplar). This processing yields sugars that can be subsequently converted to biofuels or biochemical. Material and energy consumption data from Aspen Plus were then compiled in a new Greenhouses Gases, Regulated Emissions, and Energy Use in Transportation (GREETTM) pretreatment module. The module estimates the cradle-to-gate fossil energy consumption (FEC) and greenhouse gas (GHG) emissions associated with producing fermentable sugars. This report documents the data and methodology used to develop this module and the cradle-to-gate FEC and GHG emissions that result from producing fermentable sugars.

  10. Establishment of Neural Network Prediction Model for Terminative Temperature Based on Grey Theory in Hot Metal Pretreatment

    Institute of Scientific and Technical Information of China (English)

    ZHANGHui—ning; XUAn-jun; CUIJian; HEDong—feng; TIANNai——yuan

    2012-01-01

    In order to improve the accuracy of model for terminative temperature in steelmaking, it is necessary to predict and control before decarburization. Thus, an optimization neural network model of terminative temperature in the process of dephosphorization by laying correlative degree weights to all input factors related was used. Then sim- ulation experiment of model newly established is conducted utilizing 210 data from a domestic steel plant. The results show that hit rate arrives at 56.45~~ when error is within plus or minus 5%, and the value is 100% when within ~10%. Comparing to the traditional neural network prediction model, the accuracy almost increases by 6. 839o//oo. Thus, the simulation prediction fits the real perfectly, which accounts for that neural network model for terminative tempera- ture based on grey theory can reflect accurately the practice in dephosphorization. Naturally, this method is effective and nraeticahle.

  11. Pretreatment methods for bioethanol production.

    Science.gov (United States)

    Xu, Zhaoyang; Huang, Fang

    2014-09-01

    Lignocellulosic biomass, such as wood, grass, agricultural, and forest residues, are potential resources for the production of bioethanol. The current biochemical process of converting biomass to bioethanol typically consists of three main steps: pretreatment, enzymatic hydrolysis, and fermentation. For this process, pretreatment is probably the most crucial step since it has a large impact on the efficiency of the overall bioconversion. The aim of pretreatment is to disrupt recalcitrant structures of cellulosic biomass to make cellulose more accessible to the enzymes that convert carbohydrate polymers into fermentable sugars. This paper reviews several leading acidic, neutral, and alkaline pretreatments technologies. Different pretreatment methods, including dilute acid pretreatment (DAP), steam explosion pretreatment (SEP), organosolv, liquid hot water (LHW), ammonia fiber expansion (AFEX), soaking in aqueous ammonia (SAA), sodium hydroxide/lime pretreatments, and ozonolysis are intensively introduced and discussed. In this minireview, the key points are focused on the structural changes primarily in cellulose, hemicellulose, and lignin during the above leading pretreatment technologies.

  12. PRETREATING THORIUM FOR ELECTROPLATING

    Science.gov (United States)

    Beach, J.G.; Schaer, G.R.

    1959-07-28

    A method is presented for pretreating a thorium surface prior to electroplating the surface. The pretreatment steps of the invention comprise cleaning by vapor blasting the surface, anodically pickling in a 5 to 15% by volume aqueous hydrochloric acid bath with a current of 125 to 250 amp/sq ft for 3 to 5 min at room temperature, chemically pickling the surface in a 5 to 15% by volume of aqueous sulfuric acid for 3 to 5 min at room temperature, and rinsing the surface with water.

  13. Improvements of the Vis-NIRS Model in the Prediction of Soil Organic Matter Content Using Spectral Pretreatments, Sample Selection, and Wavelength Optimization

    Science.gov (United States)

    Lin, Z. D.; Wang, Y. B.; Wang, R. J.; Wang, L. S.; Lu, C. P.; Zhang, Z. Y.; Song, L. T.; Liu, Y.

    2017-07-01

    A total of 130 topsoil samples collected from Guoyang County, Anhui Province, China, were used to establish a Vis-NIR model for the prediction of organic matter content (OMC) in lime concretion black soils. Different spectral pretreatments were applied for minimizing the irrelevant and useless information of the spectra and increasing the spectra correlation with the measured values. Subsequently, the Kennard-Stone (KS) method and sample set partitioning based on joint x-y distances (SPXY) were used to select the training set. Successive projection algorithm (SPA) and genetic algorithm (GA) were then applied for wavelength optimization. Finally, the principal component regression (PCR) model was constructed, in which the optimal number of principal components was determined using the leave-one-out cross validation technique. The results show that the combination of the Savitzky-Golay (SG) filter for smoothing and multiplicative scatter correction (MSC) can eliminate the effect of noise and baseline drift; the SPXY method is preferable to KS in the sample selection; both the SPA and the GA can significantly reduce the number of wavelength variables and favorably increase the accuracy, especially GA, which greatly improved the prediction accuracy of soil OMC with Rcc, RMSEP, and RPD up to 0.9316, 0.2142, and 2.3195, respectively.

  14. Microwave pretreatment of switchgrass for bioethanol production

    Science.gov (United States)

    Keshwani, Deepak Radhakrishin

    conditions, 82% glucose and 63% xylose yields were achieved for switchgrass, and 87% glucose and 59% xylose yields were achieved for coastal bermudagrass following enzymatic hydrolysis of the pretreated biomass. The optimum enzyme loadings were 15 FPU/g and 20 CBU/g for switchgrass and 10 FPU/g and 20 CBU/g for coastal bermudagrass. Dielectric properties for dilute sodium hydroxide solutions were measured and compared to solid loss, lignin reduction and reducing sugar levels in hydrolyzates. Results indicate that the dielectric loss tangent of alkali solutions is a potential indicator of the severity of microwave-based pretreatments. Modeling of pretreatment processes can be a valuable tool in process simulations of bioethanol production from lignocellulosic biomass. Chapter 4 discusses three different approaches that were used to model delignification and carbohydrate loss during microwave-based pretreatment of switchgrass: statistical linear regression modeling, kinetic modeling using a time-dependent rate coefficient, and a Mamdani-type fuzzy inference system. The dielectric loss tangent of the alkali reagent and pretreatment time were used as predictors in all models. The statistical linear regression model for delignification gave comparable root mean square error (RMSE) values for training and testing data and predictions were approximately within 1% of experimental values. The kinetic model for delignification and xylan loss gave comparable RMSE values for training and testing data sets and predictions were approximately within 2% of experimental values. The kinetic model for cellulose loss was not as effective and predictions were only within 5-7% of experimental values. The time-dependent rate coefficients of the kinetic models calculated from experimental data were consistent with the heterogeneity (or lack thereof) of individual biomass components. The Mamdani-type fuzzy inference system was shown to be an effective means to model pretreatment processes and gave

  15. Phase-domain power flows in the rectangular co-ordinates frame of reference including VSC-based FACTS controllers

    Energy Technology Data Exchange (ETDEWEB)

    Angeles-Camacho, C. [Universidad Nacional Autonoma de Mexico, Instituto de Ingenieria, Edif. Bernardo Quintana, Circuito Exterior Ciudad Universitaria, 04510 Mexico, D.F. (Mexico); Acha, E. [Electronics and Electrical Engineering, The University of Glasgow (United Kingdom)

    2008-03-15

    This paper presents a method for systematic modelling of VSC-based FACTS controllers within three-phase power flows in rectangular co-ordinates. Among the FACTS controllers modelled are the STATCOM, SSSC, UPFC and HVDC-VSC. The approach taken is to represent the fundamental frequency operation of each power converter as a three-phase voltage source behind a leakage reactance, where one or two of them may be connected in either series or parallel depending on the FACTS controller being modelled. Active and reactive power flow equations are developed for each voltage source circuit together with constraint equations to account for co-ordinated operation of two converters, such as in modelling of UPFC and HVDC-VSC. The power flow equations representing the VSC-based FACTS controllers are combined with the nodal power equations of the power network for a combined iterative solution using a Newton-Raphson three-phase power flow algorithm in rectangular co-ordinates enabling robust and efficient solutions of three-phase power networks with any number and kind of VSC-based controllers. (author)

  16. Why Overlearned Sequences are Special: Distinct Neural Networks for Ordinal Sequences

    Directory of Open Access Journals (Sweden)

    Vani ePariyadath

    2012-12-01

    Full Text Available Several observations suggest that overlearned ordinal categories (e.g., letters, numbers, weekdays, months are processed differently than non-ordinal categories in the brain. In synesthesia, for example, anomalous perceptual experiences are most often triggered by members of ordinal categories (Rich et al., 2005; Eagleman, 2009. In semantic dementia, the processing of ordinal stimuli appears to be preserved relative to non-ordinal ones (Cappelletti et al., 2001. Moreover, ordinal stimuli often map onto unconscious spatial representations, as observed in the SNARC effect (Dehaene et al, 1993; Fias, 1996. At present, little is known about the neural representation of ordinal categories. Using functional neuroimaging, we show that words in ordinal categories are processed in a fronto-temporo-parietal network biased toward the right hemisphere. This differs from words in non-ordinal categories (such as names of furniture, animals, cars and fruit, which show an expected bias toward the left hemisphere. Further, we find that increased predictability of stimulus order correlates with smaller regions of BOLD activation, a phenomenon we term prediction suppression. Our results provide new insights into the processing of ordinal stimuli, and suggest a new anatomical framework for understanding the patterns seen in synesthesia, unconscious spatial representation, and semantic dementia.

  17. Pre-treatment with bone marrow-derived mesenchymal stem cells inhibits systemic intravascular coagulation and attenuates organ dysfunction in lipopolysaccharide-induced disseminated intravascular coagulation rat model

    Institute of Scientific and Technical Information of China (English)

    WANG Biao; WU Shu-ming; WANG Tao; LIU Kai; ZHANG Gong; ZHANG Xi-quan; YU Jian-hua; LIU Chuan-zhen; FANG Chang-cun

    2012-01-01

    Background Bacterial lipopolysaccharide (LPS) can activate immunological cells to secrete various proinflammatory cytokines involved in the pathophysiological process of disseminated intravascular coagulation (DIC) during infection.In recent years,it has been found that bone marrow-derived mesenchymal stem cells (BMSCs) can affect the activity of these immune cells and regulate the secretion of proinflammatory cytokines.Here,we report the possible protective effect of BMSCs pre-treatment in LPS-induced DIC rat model and the mechanism.Methods Forty-eight adult male rats were divided into five experimental groups and one control group with eight animals in each group.In the treatment groups,0,1×106,2×106,3×106,and 5×106 of BMSCs were injected intravenously for 3 days before LPS injection,while the control group was treated with pure cell culture medium injection.Then,the LPS (3 mg/kg) was injected via the tail vein in the treatment groups,while the control group received 0.9% NaCl.Blood was withdrawn before and 4 and 8 hours after LPS administration.The following parameters were monitored:platelets (PLT),fibrinogen (Fib),D-dimer (D-D),activated partial thromboplastin time (APTT),prothrombin time (PT),tumor necrosis factor-o (TNF-α),interferon-γ (IFN-γ),interleukin-1β (IL-1β),creatinine (Cr),alanine aminotransferase (ALT),creatinine kinase-MB (CK-MB),and endothelin (ET).Results Compared with the control group,a significant change of coagulation parameters were found in the experimental groups.The plasma level of the inflammatory mediator (TNF-α,IFN-γ,IL-1β),organ indicator (Cr,ALT,and CK-MB),and ET in the experimental groups were much lower (P <0.05) than that in the control group.Furthermore,some of these effects were dose-dependent; the statistical comparison of the plasma levels between the groups (from group 2 to group 5) showed a significant difference (P<0.05),except the ALT and CK-MB levels (P>0.05).Conclusion Pre-treatment with BMSCs can

  18. SU-E-T-265: Development of Dose-To-Water Conversion Models for Pre-Treatment Verification with the New AS1200 Imager

    Energy Technology Data Exchange (ETDEWEB)

    Miri, N [University of Newcastle, Newcastle, NSW (Australia); Baltes, C; Keller, P [Varian Medical Systems Imaging, Baden-Dättwil (Switzerland); Greer, P [Newcastle Mater Hospital, Newcastle, NSW (Australia)

    2015-06-15

    Purpose: To develop and evaluate models for dose verification of flattened (FF) and flattening filter free (FFF) beams for the new Varian aS1200 backscatter-shielded electronic portal imaging device (EPID). Methods: The model converts EPID images to incident energy fluence using deconvolution of EPID scatter kernels and fluence to dose in water using convolution with dose-to-water kernels. Model parameters were optimized using non-transmission EPID images of varying jaw defined field sizes for energies of 6 and 10 MV FF and FFF beams. Energy fluence was obtained from the Acuros planning system and reference dose profiles and output factors were measured at depths of 5, 10, 15 and 20 cm in a water phantom. Images for 34 IMRT fields acquired at 6 and 10 MV FF energy were converted to dose at 10 cm depth in water and compared to treatment planning system dose plane calculations using gamma criteria. Results: Gamma evaluations for the IMRT fields had mean (1 standard deviation) pass rates of 99.4% (0.8%) and mean gamma scores of 0.32 (0.06) with 2%, 2 mm criteria and 10% of maximum dose threshold. Conclusion: The developed model has been shown to be highly accurate for pre-treatment verification with the new aS1200 imager which does not display support-arm backscatter artefact and has improved dosimetric properties. Further investigation of FFF modes is in progress. The model is currently being evaluated at sites for potential clinical release.

  19. A Nuclear Reactor Transient Methodology Based on Discrete Ordinates Method

    Directory of Open Access Journals (Sweden)

    Shun Zhang

    2014-01-01

    Full Text Available With the rapid development of nuclear power industry, simulating and analyzing the reactor transient are of great significance for the nuclear safety. The traditional diffusion theory is not suitable for small volume or strong absorption problem. In this paper, we have studied the application of discrete ordinates method in the numerical solution of space-time kinetics equation. The fully implicit time integration was applied and the precursor equations were solved by analytical method. In order to improve efficiency of the transport theory, we also adopted some advanced acceleration methods. Numerical results of the TWIGL benchmark problem presented demonstrate the accuracy and efficiency of this methodology.

  20. Implementing the Open Method of Co-ordination in Pensions

    Directory of Open Access Journals (Sweden)

    Jarosław POTERAJ

    2009-01-01

    Full Text Available The article presents an insight into the European Union Open Methodof Co-ordination (OMC in area of pension. The author’s goal was to presentthe development and the effects of implementation the OMC. The introductionis followed by three topic paragraphs: 1. the OMC – step by step, 2. theevaluation of the OMC, and 3. the effects of OMC implementation. In thesummary, the author highlights as except of advantages there are alsodisadvantages of the implementation of the OMC, and there are many doubtsexist in the context of efficiency of performing that method in the future.

  1. Women's Ordination in Denmark: The Humanization of the Ordained Ministry

    DEFF Research Database (Denmark)

    Pedersen, Else Marie Wiberg

    2009-01-01

    of women was legislatively made possible on June 4 1947, the drama was played out within a church-state-complex, and some of the players tried to discern between the ministry, to which women i special functions could be admitted (for example pastors in a women's prison), and the ordination, which...... of this, and corresponding to the democratization of the church was the humanization of ministry. Therefore the focus and significance of ministry is not its "who" (person and sexuality) but its "what" (the authenticity and function). The article states that it is a myth when some claim that the majority...

  2. Effect and Modeling of Glucose Inhibition and In Situ Glucose Removal During Enzymatic Hydrolysis of Pretreated Wheat Straw

    DEFF Research Database (Denmark)

    Andric, Pavle; Meyer, Anne S.; Jensen, Peter Arendt

    2010-01-01

    , during 96 h of reaction. When glucose was removed by dialysis during the enzymatic hydrolysis, the cellulose conversion rates and glucose yields increased. In fact, with dialytic in situ glucose removal, the rate of enzyme-catalyzed glucose release during 48-72 h of reaction recovered from 20......-40% to become approximate to 70% of the rate recorded during 6-24 h of reaction. Although Michaelis-Menten kinetics do not suffice to model the kinetics of the complex multi-enzymatic degradation of cellulose, the data for the glucose inhibition were surprisingly well described by simple Michaelis......-Menten inhibition models without great significance of the inhibition mechanism. Moreover, the experimental in situ removal of glucose could be simulated by a Michaelis-Menten inhibition model. The data provide an important base for design of novel reactors and operating regimes which include continuous product...

  3. A Fuzzy Group Decision Making Model for Ordinal Peer Assessment

    Science.gov (United States)

    Capuano, Nicola; Loia, Vincenzo; Orciuoli, Francesco

    2017-01-01

    Massive Open Online Courses (MOOCs) are becoming an increasingly popular choice for education but, to reach their full extent, they require the resolution of new issues like assessing students at scale. A feasible approach to tackle this problem is peer assessment, in which students also play the role of assessor for assignments submitted by…

  4. Donor pretreatment with carbamylated erythropoietin in a brain death model reduces inflammation more effectively than erythropoietin while preserving renal function

    NARCIS (Netherlands)

    Nijboer, Willemijn N.; Ottens, Petra J.; van Dijk, Antony; van Goor, Harry; Ploeg, Rutger J.; Leuvenink, Henri G. D.

    2010-01-01

    Objective: We hypothesized that donor treatment of deceased brain dead donors would lead to a decrease in inflammatory responses seen in brain death and lead to a restoration of kidney function. Design: A standardized slow-induction rat brain death model followed by evaluation of kidney function in

  5. Donor pretreatment with carbamylated erythropoietin in a brain death model reduces inflammation more effectively than erythropoietin while preserving renal function.

    NARCIS (Netherlands)

    Nijboer, W.N.; Ottens, P.J.; Dijk, A.P.J. van; Goor, H. van; Ploeg, R.J.; Leuvenink, H.G.

    2010-01-01

    OBJECTIVE: We hypothesized that donor treatment of deceased brain dead donors would lead to a decrease in inflammatory responses seen in brain death and lead to a restoration of kidney function. DESIGN: A standardized slow-induction rat brain death model followed by evaluation of kidney function in

  6. Advances in aluminum pretreatment

    Energy Technology Data Exchange (ETDEWEB)

    Sudour, Michel; Maintier, Philippe [PPG Industries France, 3 Z.A.E. Les Dix Muids, B.P. 89, F-59583 Marly (France); Simpson, Mark [PPG Industries Inc., 1200 Piedmont Troy, Michigan 48083 (United States); Quaglia, Paolo [PPG Industries Italia, Via Garavelli 21, I-15028 Quattordio (Italy)

    2004-07-01

    As automotive manufacturers continue to look for ways to reduce vehicle weight, aluminum is finding more utility as a body panel component. The substitution of cold-rolled steel and zinc-coated substrates with aluminum has led to new challenges in vehicle pretreatment. As a result, changes to traditional pretreatment chemistries and operating practices are necessary in order to produce an acceptable coating on aluminum body panels. These changes result in increased sludging and other undesirable characteristics. In addition to the chemistry changes, there are also process-related problems to consider. Many existing automotive pretreatment lines simply were not designed to handle aluminum and its increased demands on filtration and circulation equipment. To retrofit such a system is capital intensive and in addition to requiring a significant amount of downtime, may not be totally effective. Thus, the complexities of pre-treating aluminum body panels have actually had a negative effect on efforts to introduce more aluminum into new vehicle design programs. Recent research into ways of reducing the negative effects has led to a new understanding of the nature of zinc phosphate bath -aluminum interactions. Many of the issues associated with the pretreatment of aluminum have been identified and can be mitigated with only minor changes to the zinc phosphate bath chemistry. The use of low levels of soluble Fe ions, together with free fluoride, has been shown to dramatically improve the efficiency of a zinc phosphate system processing aluminum. Appearance of zinc phosphate coatings, coating weights and sludge are all benefited by this chemistry change. (authors)

  7. Co-ordinated voltage control of DFIG wind turbines in uninterrupted operation during grid faults

    DEFF Research Database (Denmark)

    Hansen, Anca Daniela; Michalke, G.; Sørensen, Poul Ejnar

    2007-01-01

    is implemented in the power system simulation toolbox PowerFactory DIgSILENT. The DFIG wind farm ride-through capability and contribution to voltage control in the power system are assessed and discussed by means of simulations with the use of a transmission power system generic model developed and delivered......-side converter as long as it is not blocked by the protection system, otherwise the grid-side converter takes over the voltage control. Moreover, the article presents a DFIG wind farm model equipped with a grid fault protection system and the described co-ordinated voltage control. The whole DFIG wind farm model...... by the Danish Transmission System Operator Energinet.dk. The simulation results show how a DFIG wind farm equipped with voltage control can help a nearby active stall wind farm to ride through a grid fault, without implementation of any additional ride-through control strategy in the active stall wind farm....

  8. Surfactant coupled sonic pretreatment of waste activated sludge for energetically positive biogas generation.

    Science.gov (United States)

    Ushani, U; Rajesh Banu, J; Tamilarasan, K; Kavitha, S; Tae Yeom, Ick

    2017-10-01

    The objective of this study was to evaluate the effect of dioctyl sodium sulphosuccinate (DOSS, a surfactant) on lysis rate of sludge and specific energy required for sonic pretreatment of waste activated sludge (WAS). Different ultrasonic power levels, WAS concentrations, DOSS dosages, and specific energy levels were used to compare pretreatment efficiencies. At an optimum time of 10min with ultrasonic power level of 160W, DOSS coupled sonic pretreatment resulted in better lysis rate (24.7%) of sludge than sonic pretreatment (17.6%). Biodegradability estimation through non-linear regression modeling revealed that DOSS coupled ultrasound pretreatment of sludge showed better biodegradability with higher hydrolysis constant (about 0.25d(-1)) than sonic pretreatment (0.19d(-1)). Nearly six times less energy was required for DOSS coupled ultrasound pretreatment compared to that required for sonic pretreatment. Therefore, DOSS coupled ultrasound pretreatment makes the pretreatment process energetically positive. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Hyperations, Veblen progressions and transfinite iterations of ordinal functions

    CERN Document Server

    Fernández-Duque, David

    2012-01-01

    In this paper we introduce hyperations and cohyperations, which are forms of transfinite iteration of ordinal functions. Hyperations are iterations of normal functions. Unlike iteration by pointwise convergence, hyperation preserves normality. The hyperation of a normal function f is a sequence of normal functions so that f^0= id, f^1 = f and for all ordinals \\alpha, \\beta we have that f^(\\alpha + \\beta) = f^\\alpha f^\\beta. These conditions do not determine f^\\alpha uniquely; in addition, we require that the functions be minimal in an appropriate sense. We study hyperations systematically and show that they are a natural refinement of Veblen progressions. Next, we define cohyperations, very similar to hyperations except that they are left-additive: given \\alpha, \\beta, f^(\\alpha + \\beta)= f^\\beta f^\\alpha. Cohyperations iterate initial functions which are functions that map initial segments to initial segments. We systematically study cohyperations and see how they can be employed to define left inverses to h...

  10. An ordinal metrical scale built on a fuzzy nominal scale

    Science.gov (United States)

    Benoit, E.

    2010-07-01

    The Measurement theory defines a measurement as a mapping from a set of empirical property manifestations to a set of abstract property values called symbols. The ordinal metrical scales were introduced within the context of Psychophysics as a way to solve the problem of multidimensional scaling. Usually the distances used to define such scales are based on the hypothesis that symbols are vectors of numbers and that each component is expressed on an interval scale or a ratio scale. In a recent paper was introduced a distance-based scale that represents manifestations from an empirical world with fuzzy subsets of lexical terms. This approach supposes only the existence of a fuzzy nominal scale and allows a choice into a wider set of distances to build the ordinal metrical scales. This paper focuses on the knowledge source used to choose a scale definition and takes metrical scales built on fuzzy nominal scale as example. Then it opens a discussion on the reality of some distances in the empirical world.

  11. Ordinal time series analysis for Air Quality Index (AQI) in San Bernardino County

    Science.gov (United States)

    Chitakasempornkul, Kessinee

    Ambient pollutant, especially ground level ozone that causes respiratory diseases, has been a great concern in Southern California. U.S. Environmental Protection Agency provides the Air Quality Index (AQI) as a tool to assist the public of health warnings. AQI for ozone is currently divided into six states depending on the level of public health concern. In statistical point of view AQI can be characterized as nonstationary ordinal-valued time series. The purpose of this study is to implement statistical models for short-term forecasting of AQI. This thesis presents a generalized linear type modeling to handle the autocorrelated ordinal time series. The model is applied with four different link functions: identity, logit, probit, and complementary log-log and their forecast performance are compared. Random time-varying covariates include past AQI state, various meteorological processes, and periodic component. Data used in this study are AQI for ozone from five monitoring stations in San Bernardino County, CA for 2004 to 2006. For the purpose of evaluating the performance of one-day-ahead forecast, the 2007 data from the same place are used. The meteorological data are from the nearby Barstow city in San Bernardino County. The portmanteau test is used to test error autocorrelations. The partial likelihood ratio test, Akaike information criterion (AIC), and Bayesian information criterion (BIC) are used to measure the goodness of fit and compare the models. The results show the model well captures the nonstationarity in ozone process and remove the nonstationarity in residuals. Both logit and probit models correctly forecast about 85% of the observed AQI.

  12. The added value of ordinal analysis in clinical trials: An example in traumatic brain injury

    OpenAIRE

    Roozenbeek, Bob; Perel, Pablo; Edwards, Phil; Roberts, Ian; Murray, Gordon; Maas, Andrew; Steyerberg, Ewout

    2011-01-01

    textabstractIntroduction: In clinical trials, ordinal outcome measures are often dichotomized into two categories. In traumatic brain injury (TBI) the 5-point Glasgow outcome scale (GOS) is collapsed into unfavourable versus favourable outcome. Simulation studies have shown that exploiting the ordinal nature of the GOS increases chances of detecting treatment effects. The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial.Me...

  13. Nonhazardous Urine Pretreatment Method

    Science.gov (United States)

    Akse, James R.; Holtsnider, John T.

    2012-01-01

    A method combines solid phase acidification with two non-toxic biocides to prevent ammonia volatilization and microbial proliferation. The safe, non-oxidizing biocide combination consists of a quaternary amine and a food preservative. This combination has exhibited excellent stabilization of both acidified and unacidified urine. During pretreatment tests, composite urine collected from donors was challenged with a microorganism known to proliferate in urine, and then was processed using the nonhazardous urine pre-treatment method. The challenge microorganisms included Escherichia coli, a common gram-negative bacteria; Enterococcus faecalis, a ureolytic gram-positive bacteria; Candida albicans, a yeast commonly found in urine; and Aspergillus niger, a problematic mold that resists urine pre-treatment. Urine processed in this manner remained microbially stable for over 57 days. Such effective urine stabilization was achieved using non-toxic, non-oxidizing biocides at higher pH (3.6 to 5.8) than previous methods in use or projected for use aboard the International Space Station (ISS). ISS urine pretreatment methods employ strong oxidants including ozone and hexavalent chromium (Cr(VI)), a carcinogenic material, under very acidic conditions (pH = 1.8 to 2.4). The method described here offers a much more benign chemical environment than previous pretreatment methods, and will lower equivalent system mass (ESM) by reducing containment volume and mass, system complexity, and crew time needed to handle pre-treatment chemicals. The biocides, being non-oxidizing, minimize the potential for chemical reactions with urine constituents to produce volatile, airborne contaminants such as cyanogen chloride. Additionally, the biocides are active under significantly less acidic conditions than those used in the current system, thereby reducing the degree of required acidification. A simple flow-through solid phase acidification (SPA) bed is employed to overcome the natural buffering

  14. Ordinal scheduling problem and its asymptotically optimal algorithms on parallel machine system

    Institute of Scientific and Technical Information of China (English)

    TAN Zhiyi; HE Yong

    2004-01-01

    Focusing on the ordinal scheduling problem on a parallel machine system, we discuss the background of ordinal scheduling and the motivation of ordinal algorithms. In addition, for the ordinal scheduling problem on identical parallel machines with the objective to maximize the minimum machine load, we then give two asymptotically optimal algorithm classes which have worst-case ratios very close to the upper bound of the problem for any given m. These results greatly improve the results proposed by He Yong and Tan Zhiyi in 2002.

  15. Assessing Pretreatment Reactor Scaling Through Empirical Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lischeske, James J.; Crawford, Nathan C.; Kuhn, Erik; Nagle, Nicholas J.; Schell, Daniel J.; Tucker, Melvin P.; McMillan, James D.; Wolfrum, Edward J.

    2016-12-01

    Pretreatment is a critical step in the biochemical conversion of lignocellulosic biomass to fuels and chemicals. Due to the complexity of the physicochemical transformations involved, predictively scaling up technology from bench- to pilot-scale is difficult. This study examines how pretreatment effectiveness under nominally similar reaction conditions is influenced by pretreatment reactor design and scale using four different pretreatment reaction systems ranging from a 3 g batch reactor to a 10 dry-ton/d continuous reactor. The reactor systems examined were an Automated Solvent Extractor (ASE), Steam Explosion Reactor (SER), ZipperClave(R) reactor (ZCR), and Large Continuous Horizontal-Screw Reactor (LHR). To our knowledge, this is the first such study performed on pretreatment reactors across a range of reaction conditions (time and temperature) and at different reactor scales. The comparative pretreatment performance results obtained for each reactor system were used to develop response surface models for total xylose yield after pretreatment and total sugar yield after pretreatment followed by enzymatic hydrolysis. Near- and very-near-optimal regions were defined as the set of conditions that the model identified as producing yields within one and two standard deviations of the optimum yield. Optimal conditions identified in the smallest-scale system (the ASE) were within the near-optimal region of the largest scale reactor system evaluated. A reaction severity factor modeling approach was shown to inadequately describe the optimal conditions in the ASE, incorrectly identifying a large set of sub-optimal conditions (as defined by the RSM) as optimal. The maximum total sugar yields for the ASE and LHR were 95%, while 89% was the optimum observed in the ZipperClave. The optimum condition identified using the automated and less costly to operate ASE system was within the very-near-optimal space for the total xylose yield of both the ZCR and the LHR, and was

  16. Biomass shock pretreatment

    Science.gov (United States)

    Holtzapple, Mark T.; Madison, Maxine Jones; Ramirez, Rocio Sierra; Deimund, Mark A.; Falls, Matthew; Dunkelman, John J.

    2014-07-01

    Methods and apparatus for treating biomass that may include introducing a biomass to a chamber; exposing the biomass in the chamber to a shock event to produce a shocked biomass; and transferring the shocked biomass from the chamber. In some aspects, the method may include pretreating the biomass with a chemical before introducing the biomass to the chamber and/or after transferring shocked biomass from the chamber.

  17. Low temperature lignocellulose pretreatment: effects and interactions of pretreatment pH are critical for maximizing enzymatic monosaccharide yields from wheat straw

    DEFF Research Database (Denmark)

    Pedersen, Mads; Johansen, Katja S.; Meyer, Anne S.

    2011-01-01

    C for 10 min. The maximal enzymatic glucose and xylose yields from the solid, pretreated wheat straw fraction were obtained after pretreatments at the most extreme pH values (pH 1 or pH 13) at the maximum pretreatment temperature of 140 degrees C. Surface response models revealed significantly...

  18. ACS Algorithm in Discrete Ordinates for Pressure Vessel Dosimetry

    Directory of Open Access Journals (Sweden)

    Walters William

    2016-01-01

    Full Text Available The Adaptive Collision Source (ACS method can solve the Linear Boltzmann Equation (LBE more efficiently by adaptation of the angular quadrature order. This is similar to, and essentially an extension of, the first collision source method. Previously, the ACS methodology has been implemented into the TITAN discrete ordinates code, and has shown speedups of 2–4 on a simple test problem, with very little loss of accuracy (within a provided adaptive tolerance. This work examines the use of the ACS method for a more realistic problem: pressure vessel dosimetry with the VENUS-2 MOX-fuelled reactor dosimetry benchmark. The ACS method proved to be able to obtain accurate results while being approximately twice as efficient as using a constant quadrature in a standard source iteration scheme.

  19. Excimer laser pretreatment and metallization of polymers

    Science.gov (United States)

    Horn, H.; Beil, S.; Wesner, D. A.; Weichenhain, R.; Kreutz, E. W.

    1999-05-01

    Metal/polymer adhesion is a crucial factor of many applications in microelectronic or microsystem technologies. It depends on chemical and structural properties of the interface, often involving just a few atomic layers. Adhesion can be influenced by various pretreatments prior to metal deposition, e.g. thermal treatment, chemical etching or exposure to reactive plasmas. Irradiation with pulsed UV-laser radiation and or UV-excimer lamps can also affect adhesion and offers several technical advantages, among them area selective pretreatment and subsequent metallization. The pretreatment of polymer surfaces by UV-radiation is investigated as an alternative technique to common wet chemical, plasma or other pretreatment methods. Chemical and morphological changes in the polymer surface are investigated with poly(butylene terephthalate) (PBT) as a model substance, containing UV-absorbing (aromatic) chromophoric groups. Chemical changes in the surface are investigated via X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared spectroscopy (FTIR). Analysis of the morphological changes in the polymer surface is done via optical microscopy and scanning electron microscopy (SEM). The metallization of polymers pretreated by excimer laser radiation is performed via electroless plating of nickel followed by electrolytically deposited copper. The influence of excimer laser irradiation of the polymer on the adhesion of the metal overlayers is measured by tape and peel tests.

  20. Case of cholera preparedness, response and prevention in the SADC region: A need for proactive and multi-level communication and co-ordination

    CSIR Research Space (South Africa)

    Said, MD

    2011-10-01

    Full Text Available In this paper the authors seek to identify the most appropriate model for a regional co-ordination mechanism for cholera preparedness, response and prevention. The qualitative mixed-method data collection approach that was followed revealed the need...

  1. 78 FR 15037 - Bishop Paiute Tribe-Liquor Control Ordinance No. 2012-07

    Science.gov (United States)

    2013-03-08

    ... sovereignty and a government to government relationship with the United States of America, has all the rights..., 1961. This Ordinance (2012-07) does not change or affect any provisions of the General Council... liquor/alcohol beverages under this ordinance. .02 ``Liquor/Alcohol Beverage'' includes all...

  2. Dominant supply chain co-ordination strategies in the Dutch aerospace industry

    NARCIS (Netherlands)

    Voordijk, Johannes T.; Meijboom, Bert

    2005-01-01

    Purpose – Firms in the aerospace industry face considerable pressure to improve co-ordination in their supply chains. The major question of the present study is what supply chain co-ordination strategies are dominant in the Dutch aerospace industry given the market environment of this industry?

  3. Dominant supply chain co-ordination strategies in the Dutch aerospace industry

    NARCIS (Netherlands)

    Voordijk, Hans; Meijboom, Bert

    2005-01-01

    Purpose – Firms in the aerospace industry face considerable pressure to improve co-ordination in their supply chains. The major question of the present study is what supply chain co-ordination strategies are dominant in the Dutch aerospace industry given the market environment of this industry? De

  4. Increasing Magnitude "Counts" More: Asymmetrical Processing of Ordinality in 4-Month-Old Infants

    Science.gov (United States)

    Cassia, Viola Macchi; Picozzi, Marta; Girelli, Luisa; de Hevia, Maria Dolores

    2012-01-01

    While infants' ability to discriminate quantities has been extensively studied, showing that this competence is present even in neonates, the ability to compute ordinal relations between magnitudes has received much less attention. Here we show that the ability to represent ordinal information embedded in size-based sequences is apparent at 4…

  5. 40 CFR 35.935-16 - Sewer use ordinance and evaluation/rehabilitation program.

    Science.gov (United States)

    2010-07-01

    .../rehabilitation program. 35.935-16 Section 35.935-16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...-Clean Water Act § 35.935-16 Sewer use ordinance and evaluation/rehabilitation program. (a) The grantee... sewer use ordinance, and the grantee is complying with the sewer system evaluation and...

  6. Introducing Students to Plant Geography: Polar Ordination Applied to Hanging Gardens.

    Science.gov (United States)

    Malanson, George P.; And Others

    1993-01-01

    Reports on a research study in which college students used a statistical ordination method to reveal relationships among plant community structures and physical, disturbance, and spatial variables. Concludes that polar ordination helps students understand the methodology of plant geography and encourages further student research. (CFR)

  7. The Development and Standardization of the Adult Developmental Co-Ordination Disorders/Dyspraxia Checklist (ADC)

    Science.gov (United States)

    Kirby, Amanda; Edwards, Lisa; Sugden, David; Rosenblum, Sara

    2010-01-01

    Developmental Co-ordination Disorder (DCD), also known as Dyspraxia in the United Kingdom (U.K.), is a developmental disorder affecting motor co-ordination. In the past this was regarded as a childhood disorder, however there is increasing evidence that a significant number of children will continue to have persistent difficulties into adulthood.…

  8. Application of ordinal logistic regression analysis in determining risk factors of child malnutrition in Bangladesh.

    Science.gov (United States)

    Das, Sumonkanti; Rahman, Rajwanur M

    2011-11-14

    The study attempts to develop an ordinal logistic regression (OLR) model to identify the determinants of child malnutrition instead of developing traditional binary logistic regression (BLR) model using the data of Bangladesh Demographic and Health Survey 2004. Based on weight-for-age anthropometric index (Z-score) child nutrition status is categorized into three groups-severely undernourished (malnutrition and severe malnutrition if the proportional odds assumption satisfies. The assumption is satisfied with low p-value (0.144) due to violation of the assumption for one co-variate. So partial proportional odds model (PPOM) and two BLR models have also been developed to check the applicability of the OLR model. Graphical test has also been adopted for checking the proportional odds assumption. All the models determine that age of child, birth interval, mothers' education, maternal nutrition, household wealth status, child feeding index, and incidence of fever, ARI & diarrhoea were the significant predictors of child malnutrition; however, results of PPOM were more precise than those of other models. These findings clearly justify that OLR models (POM and PPOM) are appropriate to find predictors of malnutrition instead of BLR models.

  9. No toy for you! The healthy food incentives ordinance: paternalism or consumer protection?

    Science.gov (United States)

    Etow, Alexis M

    2012-01-01

    The newest approach to discouraging children's unhealthy eating habits, amidst increasing rates of childhood obesity and other diet-related diseases, seeks to ban something that is not even edible. In 2010, San Francisco enacted the Healthy Food Incentives Ordinance, which prohibits toys in kids' meals if the meals do not meet certain nutritional requirements. Notwithstanding the Ordinance's impact on interstate commerce or potential infringement on companies' commercial speech rights and on parents' rights to determine what their children eat, this Comment argues that the Ordinance does not violate the dormant Commerce Clause, the First Amendment, or substantive due process. The irony is that although the Ordinance likely avoids the constitutional hurdles that hindered earlier measures aimed at childhood obesity, it intrudes on civil liberties more than its predecessors. This Comment analyzes the legality of the Healthy Food Incentives Ordinance to understand its implications on subsequent legislation aimed at combating childhood obesity and on the progression of public health law.

  10. Lignocellulosic Biomass Pretreatment Using AFEX

    Science.gov (United States)

    Balan, Venkatesh; Bals, Bryan; Chundawat, Shishir P. S.; Marshall, Derek; Dale, Bruce E.

    Although cellulose is the most abundant organic molecule, its susceptibility to hydrolysis is restricted due to the rigid lignin and hemicellulose protection surrounding the cellulose micro fibrils. Therefore, an effective pretreatment is necessary to liberate the cellulose from the lignin-hemicellulose seal and also reduce cellulosic crystallinity. Some of the available pretreatment techniques include acid hydrolysis, steam explosion, ammonia fiber expansion (AFEX), alkaline wet oxidation, and hot water pretreatment. Besides reducing lignocellulosic recalcitrance, an ideal pretreatment must also minimize formation of degradation products that inhibit subsequent hydrolysis and fermentation. AFEX is an important pretreatment technology that utilizes both physical (high temperature and pressure) and chemical (ammonia) processes to achieve effective pretreatment. Besides increasing the surface accessibility for hydrolysis, AFEX promotes cellulose decrystallization and partial hemicellulose depolymerization and reduces the lignin recalcitrance in the treated biomass. Theoretical glucose yield upon optimal enzymatic hydrolysis on AFEX-treated corn stover is approximately 98%. Furthermore, AFEX offers several unique advantages over other pretreatments, which include near complete recovery of the pretreatment chemical (ammonia), nutrient addition for microbial growth through the remaining ammonia on pretreated biomass, and not requiring a washing step during the process which facilitates high solid loading hydrolysis. This chapter provides a detailed practical procedure to perform AFEX, design the reactor, determine the mass balances, and conduct the process safely.

  11. Lignocellulosic biomass pretreatment using AFEX.

    Science.gov (United States)

    Balan, Venkatesh; Bals, Bryan; Chundawat, Shishir P S; Marshall, Derek; Dale, Bruce E

    2009-01-01

    Although cellulose is the most abundant organic molecule, its susceptibility to hydrolysis is restricted due to the rigid lignin and hemicellulose protection surrounding the cellulose micro fibrils. Therefore, an effective pretreatment is necessary to liberate the cellulose from the lignin-hemicellulose seal and also reduce cellulosic crystallinity. Some of the available pretreatment techniques include acid hydrolysis, steam explosion, ammonia fiber expansion (AFEX), alkaline wet oxidation, and hot water pretreatment. Besides reducing lignocellulosic recalcitrance, an ideal pretreatment must also minimize formation of degradation products that inhibit subsequent hydrolysis and fermentation. AFEX is an important pretreatment technology that utilizes both physical (high temperature and pressure) and chemical (ammonia) processes to achieve effective pretreatment. Besides increasing the surface accessibility for hydrolysis, AFEX promotes cellulose decrystallization and partial hemicellulose depolymerization and reduces the lignin recalcitrance in the treated biomass. Theoretical glucose yield upon optimal enzymatic hydrolysis on AFEX-treated corn stover is approximately 98%. Furthermore, AFEX offers several unique advantages over other pretreatments, which include near complete recovery of the pretreatment chemical (ammonia), nutrient addition for microbial growth through the remaining ammonia on pretreated biomass, and not requiring a washing step during the process which facilitates high solid loading hydrolysis. This chapter provides a detailed practical procedure to perform AFEX, design the reactor, determine the mass balances, and conduct the process safely.

  12. Human Action Recognition Using Ordinal Measure of Accumulated Motion

    Directory of Open Access Journals (Sweden)

    Kim Wonjun

    2010-01-01

    Full Text Available This paper presents a method for recognizing human actions from a single query action video. We propose an action recognition scheme based on the ordinal measure of accumulated motion, which is robust to variations of appearances. To this end, we first define the accumulated motion image (AMI using image differences. Then the AMI of the query action video is resized to a subimage by intensity averaging and a rank matrix is generated by ordering the sample values in the sub-image. By computing the distances from the rank matrix of the query action video to the rank matrices of all local windows in the target video, local windows close to the query action are detected as candidates. To find the best match among the candidates, their energy histograms, which are obtained by projecting AMI values in horizontal and vertical directions, respectively, are compared with those of the query action video. The proposed method does not require any preprocessing task such as learning and segmentation. To justify the efficiency and robustness of our approach, the experiments are conducted on various datasets.

  13. Eurotrac: a co-ordinated project for applied tropospheric research

    Energy Technology Data Exchange (ETDEWEB)

    Borrell, P. [EUROTRAC International Scientific Secretariat, Garmisch-Partenkirchen (Germany)

    1995-12-31

    It was with the realisation that the scientific problems associated with regional air pollution could only be solved within the framework of an international interdisciplinary approach that in 1985 EUROTRAC, the European co-ordinated research project, was formed. Such an approach provides the scientific consensus necessary for the acceptance of regional air-pollution abatement measures by the countries affected. EUROTRAC is a EUREKA environmental project, studying the transport and chemical transformation of trace substances and pollutants in the troposphere. Three goals were specified the outset: (1) to increase the basic knowledge in atmospheric science, (2) to promote the technological development of sensitive, specific and fast response instruments for environmental research and development, and (3) to improve the scientific basis for taking future political decisions on environmental management in the European countries. Thus EUROTRAC was founded as a scientific project but had the specific intention that its results should be utilised in the formulation of policy. This presentation reviews the progress made towards each of the three goals and also indicates the proposed direction which a follow-on project is likely to take when EUROTRAC finishes at the end of 1995. (author)

  14. Metal selective co-ordinative self-assembly of -donors

    Indian Academy of Sciences (India)

    Ankit Jain; K Venkata Rao; Ankita Goswami; Subi J George

    2011-11-01

    Metal selective co-ordinative nanostructures were constructed by the supramolecular co-assembly of pyridine appended TTF (TTF-Py) and pyrene (PYR-Py) derivatives in appropriate solvent composition mixtures with metal ions.Microscopic analyses show that TTF-Py shows distinctive morphology with either of these metal ions, forming I-D tapes with 1:1 Pb2+ complex and 2-D sheets with 1:2 Zn2+ complex. A rationale has been provided from molecular level packing for such hierarchical changes. In case of Cu2+, we have observed an anomalous binding of metal ion to the core sulphur groups causing redox changes in the TTF core. PYR-Py on the other hand is shown to be a fluorescent sensor for Pb2+, Zn2+, Hg2+ and Ag+. With different fluorescent response for metal complexes, we essentially obtained similar 1-D assemblies suggesting similar binding modes for all of them. Supramolecular approach through which morphology of an electron donor moiety can be engineered by metal ions can be a new tool in nanoelectronics.

  15. Asymptotically Optimal Assignments In Ordinal Evaluations of Proposals

    CERN Document Server

    Oruc, A Yavuz

    2009-01-01

    In ordinal evaluations of proposals in peer review systems, a set of proposals is assigned to a fixed set of referees so as to maximize the number of pairwise comparisons of proposals under certain referee capacity and proposal subject constraints. In this paper, the following two related problems are considered: (1) Assuming that each referee has a capacity to review k out of n proposals, 2 < k < n, determine the minimum number of referees needed to ensure that each pair of proposals is reviewed by at least one referee, (2) Find an assignment that meets the lower bound determined in (1). It is easy to see that one referee is both necessary and sufficient when k = n, and n(n-1)/2 referees are both necessary and sufficient when k = 2. We show that 6 referees are both necessary and sufficient when k = n/2. We further show that 11 referees are necessary and 12 are sufficient when k = n/3, and 18 referees are necessary and 20 referees are sufficient when k = n/4. A more general lower bound of n(n-1)/k(k-1) ...

  16. Liturgical Ecclesiology of the Sacrament of Ordination in the Eastern Rite

    Directory of Open Access Journals (Sweden)

    Przemysław Nowakowski

    2010-06-01

    Full Text Available The subject matter of the above paper is the role and position of the Church community in the rite of ordination to the priesthood in the byzantine tradition. It has been considered the split of the orthodox ministers into the church ministers (lower ordination and ordained ministers (higher ordination. The influence of the local community upon the election of the candidates to priesthood has been weakened with time and nowadays within the Orthodox Church only the local bishop decides about the appointment of the new ministers and only the imposition of hands is regarded as the sacramental rite. The contemporary liturgy of ordination, however, has preserved some significant elements reminding us about the former equal importance of the community influence, who used to elect by offering to God and at the same time to accept their shepherds. This role of the Church is expressed by three main parts of the rites: 1 the election of a candidate, 2 the imposition of hands of the bishop and prayer, 3 the reception of ordination and of the newly ordained. Out of the presented liturgy of ordination one can draw the outline of the eastern ecclesiology of the sacrament of ordination, already elaborated by Prof. N. Afanasiev. This kind of liturgical ecclesiology may be of some help to the contemporary Church in regaining her more active role in electing and apointing her ministers and shepherds.

  17. Awareness on the Implementation of Anti-Smoking Ordinance No. 1S. 2012

    Directory of Open Access Journals (Sweden)

    Rowena E. Mojares

    2014-10-01

    Full Text Available This study aimed to identify the respondent’s profile variable such as gender, age, educational attainment, occupation, and frequency of smoking; to identify the level of awareness of the public on Anti-Smoking Ordinance and to determine the significant difference on the level of awareness in the implementation when grouped according to profile variables. The researchers used the descriptive method of research and utilized two hundred-four (204 respondents. The result showed that the respondents are dominated by male, college graduate and under graduate and most of them are private employees. They agreed that they are aware on the implementation of anti-smoking ordinance no. 1S 2012 because the ordinance was clearly stated, well disseminated, there are authorities prohibiting it and there is a usage of signage. But they agree also that they are less aware about the specific boundary that the ordinance covered, that there is regular monitoring and there is enough number of personnel implementing the ordinance. The researchers recommended that the Pamahalaang Panglunsod may continue to maintain the strict implementation of the Anti-Smoking Ordinance; authorities should specify the boundary covered by the Ordinance and should have enough personnel to implement it,

  18. CANOCO Reference Manual and CanoDraw for Windows User's Guide: Software for Canonical Community Ordination (version 4.5)

    NARCIS (Netherlands)

    Braak, ter C.J.F.; Smilauer, P.

    2002-01-01

    Canoco is a software package for multivariate data analysis, with an emphasis on dimesional reduction (ordination), regression analysis, and the combination of the two, constrained ordination. Canoco makes effective and powerful ordination methods easilyt accessible for scientists wanting to infer a

  19. Tourism and hotel revenues before and after passage of smoke-free restaurant ordinances.

    Science.gov (United States)

    Glantz, S A; Charlesworth, A

    1999-05-26

    Claims that ordinances requiring smoke-free restaurants will adversely affect tourism have been used to argue against passing such ordinances. Data exist regarding the validity of these claims. To determine the changes in hotel revenues and international tourism after passage of smoke-free restaurant ordinances in locales where the effect has been debated. Comparison of hotel revenues and tourism rates before and after passage of 100% smoke-free restaurant ordinances and comparison with US hotel revenue overall. Three states (California, Utah, and Vermont) and 6 cities (Boulder, Colo; Flagstaff, Ariz; Los Angeles, Calif; Mesa, Ariz; New York, NY; and San Francisco, Calif) in which the effect on tourism of smoke-free restaurant ordinances had been debated. Hotel room revenues and hotel revenues as a fraction of total retail sales compared with preordinance revenues and overall US revenues. In constant 1997 dollars, passage of the smoke-free restaurant ordinance was associated with a statistically significant increase in the rate of change of hotel revenues in 4 localities, no significant change in 4 localities, and a significant slowing in the rate of increase (but not a decrease) in 1 locality. There was no significant change in the rate of change of hotel revenues as a fraction of total retail sales (P=.16) or total US hotel revenues associated with the ordinances when pooled across all localities (P = .93). International tourism was either unaffected or increased following implementation of the smoke-free ordinances. Smoke-free ordinances do not appear to adversely affect, and may increase, tourist business.

  20. Analysis of co-ordination between breathing and exercise rhythms in man.

    Science.gov (United States)

    Bernasconi, P; Kohl, J

    1993-11-01

    1. The purpose of the present study was to analyse the incidence and type of coordination between breathing rhythm and leg movements during running and to assess the effect of co-ordination on the running efficiency, as well as to compare the results with those found during cycling. 2. The experiments were carried out on thirty-four untrained volunteers exercising at two work loads (60 and 80% of subject's physical work capacity 170) on a treadmill. In addition nineteen of the subjects exercised at the same two work loads on a bicycle ergometer. The subjects were running at both work loads in three different modes in randomized order: with normal arm movements, without arm movements and with breathing paced by an acoustic signal which was triggered by the leg movement. 3. Respiratory variables, oxygen uptake and leg movements were continuously recorded and evaluated on-line. The degree of co-ordination was expressed as a percentage of inspirations and/or expirations starting in the same phase of the step or pedalling cycle. 4. The average degree of co-ordination was higher during running (up to 40%) than during cycling (about 20%) during both work loads. The difference in the degree of co-ordination between running and cycling is probably not due to the lack of arm movements during cycling since the degree of co-ordination during running with and without arm movements was the same. 5. The degree of co-ordination during running increased slightly but not significantly with increasing work load and could be increased significantly by paced breathing. 6. The co-ordination between breathing and running rhythms occurred in three different patterns: (a) breathing was co-ordinated all the time with the same phase of step, (b) co-ordination switched suddenly from one phase of step to another and (c) co-ordination ensued alternatively once on the right and once on the left leg movement. During cycling the pattern described in (a) occurred almost exclusively. 7. During

  1. Dissolved organic nitrogen measurement using dialysis pretreatment.

    Science.gov (United States)

    Lee, Wontae; Westerhoff, Paul

    2005-02-01

    Dissolved organic nitrogen (DON) is important for ecological and engineering researches. Quantification of low DON concentrations in waters with elevated dissolved inorganic nitrogen (DIN) using existing methods is inaccurate. In this study, a dialysis-based pretreatment technique was optimized and adopted to reduce the interference from DIN to the quantification of DON in natural water. A cellulose ester dialysis tube (nominal molecular weight cutoff = 100 Da) was used in batch and continuous-flow dialysis steps with model compounds, natural organic matter isolates, and bulk waters to develop a dialysis pretreatment approach that selectively reduces DIN from solutions containing DON. By reducing DIN concentrations, propagation of analytical variance in total dissolved nitrogen (TDN) and DIN species concentrations allows more accurate determination of DON (DON = TDN - NO3 - NO2- - NH3/NH4+). Dialysis for 24 h against continuously flowing distilled water reduced DIN species by 70%. With dialysis pretreatment, DON recoveries of more than 95% were obtained for surface water and finished drinking water, but wastewater experienced a slight loss (approximately 10%) of DON possibly due to the adsorption of organics onto the dialysis membrane, permeation of low molecular weight fractions, or biodegradation. Dialysis experiments using surface water spiked with different DIN/TDN ratios concluded that dialysis pretreatment leads to more accurate DON determination than no dialysis when DIN/TDN ratios exceed 0.6 mg of N/mg of N.

  2. Effect of moisture on pretreatment efficiency for anaerobic digestion of lignocellulosic substrates.

    Science.gov (United States)

    Peces, M; Astals, S; Mata-Alvarez, J

    2015-12-01

    The present study evaluates the effect of moisture in low-temperature and ultrasound pretreatment on lignocellulosic substrates anaerobic biodegradability, where brewer's spent grain was used as model substrate. Besides moisture content, low-temperature pretreatment was also evaluated in terms of temperature (60-80°C) and exposure time (12-72 h). Likewise, ultrasonication was also evaluated in terms of specific energy (1000-50,000 kJ kg TS(-1)). In addition, the effect of substrate particle size reduction by milling pretreatment was also considered. The results clearly demonstrated that substrate moisture (total solid concentration) is a significant parameter for pretreatment performance, although it has been rarely considered in pretreatment optimisation. Specifically, moisture optimisation increased the methane yield of brewer's spent grain by 6% for low-temperature pretreatment (60°C), and by 14% for ultrasound pretreatment (1000 kJ kg TS(-1)) towards the control (without pretreatment). In both pretreatments, the experimental optimum total solid concentration was 100 gTS kg(-1). Thus, lowering substrate moisture, a strategy suggested attaining energetic pretreatment feasibility, needs to be analysed as another pretreatment variable since it might have limited correlation. Finally, a preliminary energetic balance of the pretreatments under study showed that the extra methane production could not cover the energetic pretreatment expenses. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Discrete-ordinate radiative transfer in a stratified medium with first-order rotational Raman scattering

    Energy Technology Data Exchange (ETDEWEB)

    Spurr, Robert [RT Solutions Inc., 9 Channing Street, Cambridge, MA 02138 (United States)], E-mail: rtsolutions@verizon.net; Haan, Johan de; Oss, Roeland van [KNMI, de Bilt (Netherlands); Vasilkov, Alexander [SSAI, Lanham, MD (United States)

    2008-02-15

    Rotational Raman scattering (RRS) by air molecules in the Earth's atmosphere is predominantly responsible for the Ring effect: Fraunhofer and absorption-feature filling-in observed in UV/visible backscatter spectra. Accurate determination of RRS effects requires detailed radiative transfer (RT) treatment. In this paper, we demonstrate that the discrete-ordinate RT equations may be solved analytically in a multi-layer multiple scattering atmosphere in the presence of RRS treated as a first-order perturbation. Based on this solution, we develop a generic pseudo-spherical RT model LIDORT-RRS for the determination of backscatter radiances with RRS included; the model will generate output at arbitrary viewing geometry and optical thickness. Model comparisons with measured RRS filling-in effects from OMI observations show very good agreement. We examine telluric RRS filling-in effects for satellite-view backscatter radiances in a spectral range covering the ozone Huggins absorption bands. The model is also used to investigate calcium H and K Fraunhofer filling-in through cloud layers in the atmosphere.

  4. The Outlier Detection for Ordinal Data Using Scalling Technique of Regression Coefficients

    Science.gov (United States)

    Adnan, Arisman; Sugiarto, Sigit

    2017-06-01

    The aims of this study is to detect the outliers by using coefficients of Ordinal Logistic Regression (OLR) for the case of k category responses where the score from 1 (the best) to 8 (the worst). We detect them by using the sum of moduli of the ordinal regression coefficients calculated by jackknife technique. This technique is improved by scalling the regression coefficients to their means. R language has been used on a set of ordinal data from reference distribution. Furthermore, we compare this approach by using studentised residual plots of jackknife technique for ANOVA (Analysis of Variance) and OLR. This study shows that the jackknifing technique along with the proper scaling may lead us to reveal outliers in ordinal regression reasonably well.

  5. Testing the results of municipal mixed-use zoning ordinances: a novel methodological approach.

    Science.gov (United States)

    Cannon, Carol L; Thomas, Sue; Treffers, Ryan D; Paschall, Mallie J; Heumann, Lauren; Mann, Gregory W; Dunkell, Dashiell O; Nauenberg, Saskia

    2013-08-01

    Municipal mixed-use zoning (MUZ) is one public health strategy to create more walkable neighborhoods by reducing the separation of daily activities. This study uses a novel data-gathering methodology to evaluate municipal zoning ordinances in twenty-two California cities in conjunction with the walkability potential of resulting mixed-use zones, to explore the extent to which variations in uses mandated by MUZ ordinances are correlated with variations in walking opportunities. We find that, after controlling for population, socioeconomic status, and zone size, significant relationships exist between the range and precision of uses mandated by MUZ ordinances and the mixture and breadth of walking destinations in these zones. The study also demonstrates that analysis of municipal zoning codes and a novel data-gathering methodology yield valid data. The analysis of MUZ ordinances is a significant complement to other approaches to measuring walkability and can be used across cities.

  6. Breakdown of hierarchical architecture in cellulose during dilute acid pretreatments

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yan [Northeastern Univ., Boston, MA (United States); Inouye, Hideyo [Northeastern Univ., Boston, MA (United States); Yang, Lin [Brookhaven National Lab. (BNL), Upton, NY (United States); Himmel, Michael E. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tucker, Melvin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Makowski, Lee [Northeastern Univ., Boston, MA (United States)

    2015-02-28

    Cellulose can work as a feedstock for sustainable bioenergy because of its global abundance. Pretreatment of biomass has significant influence on the chemical availability of cellulose locked in recalcitrant microfibrils. Optimizing pretreatment depends on an understanding of its impact on the microscale and nanoscale molecular architecture. X-ray scattering experiments have been performed on native and pre-treated maize stover and models of cellulose architecture have been derived from these data. Ultra small-angle, very small-angle and small-angle X-ray scattering (USAXS, VSAXS and SAXS) probe three different levels of architectural scale. USAXS and SAXS have been used to study cellulose at two distinct length scales, modeling the fibrils as ~30 Å diameter rods packed into ~0.14 μm diameter bundles. VSAXS is sensitive to structural features at length scales between these two extremes. Detailed analysis of diffraction patterns from untreated and pretreated maize using cylindrical Guinier plots and the derivatives of these plots reveals the presence of substructures within the ~0.14 μm diameter bundles that correspond to grouping of cellulose approximately 30 nm in diameter. These sub-structures are resilient to dilute acid pretreatments but are sensitive to pretreatment when iron sulfate is added. Our results provide evidence of the hierarchical arrangement of cellulose at three length scales and the evolution of these arrangements during pre-treatments.

  7. Impact of San Francisco's toy ordinance on restaurants and children's food purchases, 2011-2012.

    Science.gov (United States)

    Otten, Jennifer J; Saelens, Brian E; Kapphahn, Kristopher I; Hekler, Eric B; Buman, Matthew P; Goldstein, Benjamin A; Krukowski, Rebecca A; O'Donohue, Laura S; Gardner, Christopher D; King, Abby C

    2014-07-17

    In 2011, San Francisco passed the first citywide ordinance to improve the nutritional standards of children's meals sold at restaurants by preventing the giving away of free toys or other incentives with meals unless nutritional criteria were met. This study examined the impact of the Healthy Food Incentives Ordinance at ordinance-affected restaurants on restaurant response (eg, toy-distribution practices, change in children's menus), and the energy and nutrient content of all orders and children's-meal-only orders purchased for children aged 0 through 12 years. Restaurant responses were examined from January 2010 through March 2012. Parent-caregiver/child dyads (n = 762) who were restaurant customers were surveyed at 2 points before and 1 seasonally matched point after ordinance enactment at Chain A and B restaurants (n = 30) in 2011 and 2012. Both restaurant chains responded to the ordinance by selling toys separately from children's meals, but neither changed their menus to meet ordinance-specified nutrition criteria. Among children for whom children's meals were purchased, significant decreases in kilocalories, sodium, and fat per order were likely due to changes in children's side dishes and beverages at Chain A. Although the changes at Chain A did not appear to be directly in response to the ordinance, the transition to a more healthful beverage and default side dish was consistent with the intent of the ordinance. Study results underscore the importance of policy wording, support the concept that more healthful defaults may be a powerful approach for improving dietary intake, and suggest that public policies may contribute to positive restaurant changes.

  8. Effectiveness of Occluded Object Representations at Displaying Ordinal Depth Information in Augmented Reality

    Science.gov (United States)

    2013-03-01

    Displaying Ordinal Depth Information in Augmented Reality 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...Effectiveness of Occluded Object Representations at Displaying Ordinal Depth Information in Augmented Reality Mark A. Livingston∗ Naval Research Laboratory...effectively impossible with all icon styles, whereas in the case of partial overlap, the Ground Plane had a clear advantage. Keywords: Augmented reality , human

  9. Reduction from cost-sensitive ordinal ranking to weighted binary classification.

    Science.gov (United States)

    Lin, Hsuan-Tien; Li, Ling

    2012-05-01

    We present a reduction framework from ordinal ranking to binary classification. The framework consists of three steps: extracting extended examples from the original examples, learning a binary classifier on the extended examples with any binary classification algorithm, and constructing a ranker from the binary classifier. Based on the framework, we show that a weighted 0/1 loss of the binary classifier upper-bounds the mislabeling cost of the ranker, both error-wise and regret-wise. Our framework allows not only the design of good ordinal ranking algorithms based on well-tuned binary classification approaches, but also the derivation of new generalization bounds for ordinal ranking from known bounds for binary classification. In addition, our framework unifies many existing ordinal ranking algorithms, such as perceptron ranking and support vector ordinal regression. When compared empirically on benchmark data sets, some of our newly designed algorithms enjoy advantages in terms of both training speed and generalization performance over existing algorithms. In addition, the newly designed algorithms lead to better cost-sensitive ordinal ranking performance, as well as improved listwise ranking performance.

  10. Biomass pretreatment: fundamentals toward application.

    Science.gov (United States)

    Agbor, Valery B; Cicek, Nazim; Sparling, Richard; Berlin, Alex; Levin, David B

    2011-01-01

    Development of sustainable energy systems based on renewable biomass feedstocks is now a global effort. Lignocellulosic biomass contains polymers of cellulose, hemicellulose, and lignin, bound together in a complex structure. Liquid biofuels, such as ethanol, can be made from biomass via fermentation of sugars derived from the cellulose and hemicellulose within lignocellulosic materials, but the biomass must be subjected to pretreatment processes to liberate the sugars needed for fermentation. Production of value-added co-products along-side biofuels through integrated biorefinery processes creates the need for selectivity during pretreatment. This paper presents a survey of biomass pretreatment technologies with emphasis on concepts, mechanism of action and practicability. The advantages and disadvantages, and the potential for industrial applications of different pretreatment technologies are the highlights of this paper. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. Experiences in the parallelization of the discrete ordinates method using OpenMP and MPI

    Energy Technology Data Exchange (ETDEWEB)

    Pautz, A. [TUV Hannover/Sachsen-Anhalt e.V. (Germany); Langenbuch, S. [Gesellschaft fur Anlagen- und Reaktorsicherheit (GRS) mbH (Germany)

    2003-07-01

    The method of Discrete Ordinates is in principle parallelizable to a high degree, since the transport 'mesh sweeps' are mutually independent for all angular directions. However, in the well-known production code Dort such a type of angular domain decomposition has to be done on a spatial line-byline basis, causing the parallelism in the code to be very fine-grained. The construction of scalar fluxes and moments requires a large effort for inter-thread or inter-process communication. We have implemented two different parallelization approaches in Dort: firstly, we have used a shared-memory model suitable for SMP (Symmetric Multiprocessor) machines based on the standard OpenMP. The second approach uses the well-known Message Passing Interface (MPI) to establish communication between parallel processes running in a distributed-memory environment. We investigate the benefits and drawbacks of both models and show first results on performance and scaling behaviour of the parallel Dort code. (authors)

  12. Biorefining of wheat straw: accounting for the distribution of mineral elements in pretreated biomass by an extended pretreatment – severity equation

    DEFF Research Database (Denmark)

    Le, Duy Michael; Sørensen, Hanne Risbjerg; Knudsen, Niels Ole

    2014-01-01

    Background: Mineral elements present in lignocellulosic biomass feedstocks may accumulate in biorefinery process streams and cause technological problems, or alternatively can be reaped for value addition. A better understanding of the distribution of minerals in biomass in response to pretreatment......, and treatment time), and to assess whether it is possible to model mineral levels in the pretreated fiber fraction. Results: Principal component analysis of the wheat straw biomass constituents, including mineral elements, showed that the recovered levels of wheat straw constituents after different hydrothermal...... fiber fractions. A new expanded pretreatment-severity equation is proposed to model and predict mineral composition in pretreated wheat straw biomass...

  13. Processes for pretreating lignocellulosic biomass: A review

    Energy Technology Data Exchange (ETDEWEB)

    McMillan, J D

    1992-11-01

    This paper reviews existing and proposed pretreatment processes for biomass. The focus is on the mechanisms by which the various pretreatments act and the influence of biomass structure and composition on the efficacy of particular pretreatment techniques. This analysis is used to identify pretreatment technologies and issues that warrant further research.

  14. Processes for pretreating lignocellulosic biomass: A review

    Energy Technology Data Exchange (ETDEWEB)

    McMillan, J.D.

    1992-11-01

    This paper reviews existing and proposed pretreatment processes for biomass. The focus is on the mechanisms by which the various pretreatments act and the influence of biomass structure and composition on the efficacy of particular pretreatment techniques. This analysis is used to identify pretreatment technologies and issues that warrant further research.

  15. Care co-ordination for older people in the third sector: scoping the evidence.

    Science.gov (United States)

    Abendstern, Michele; Hughes, Jane; Jasper, Rowan; Sutcliffe, Caroline; Challis, David

    2017-01-24

    The third sector has played a significant role internationally in the delivery of adult social care services for many years. Its contribution to care co-ordination activities for older people, however, in England and elsewhere, is relatively unknown. A scoping review was therefore conducted to ascertain the character of the literature, the nature and extent of third sector care co-ordination activity, and to identify evidence gaps. It was undertaken between autumn 2013 and summer 2014 and updated with additional searches in 2016. Electronic and manual searches of international literature using distinct terms for different approaches to care co-ordination were undertaken. From a total of 835 papers, 26 met inclusion criteria. Data were organised in relation to care co-ordination approaches, types of third sector organisation and care recipients. Papers were predominantly from the UK and published this century. Key findings included that: a minority of literature focused specifically on older people and that those doing so described only one care co-ordination approach; third sector services tended to be associated with independence and person-centred practice; and working with the statutory sector, a prerequisite of care co-ordination, was challenging and required a range of features to be in place to support effective partnerships. Strengths and weaknesses of care co-ordination practice in the third sector according to key stakeholder groups were also highlighted. Areas for future research included the need for: a specific focus on older people's experiences; an investigation of workforce issues; detailed examination of third sector practices, outcomes and costs; interactions with the statutory sector; and an examination of quality assurance systems and their appropriateness to third sector practice. The main implication of the findings is a need to nurture variety within the third sector in order to provide older people and other adults with the range of service

  16. Levels of disability in the older population of England: Comparing binary and ordinal classifications.

    Science.gov (United States)

    Pongiglione, Benedetta; Ploubidis, George B; De Stavola, Bianca L

    2017-10-01

    Recent studies suggest the importance of distinguishing severity levels of disability. Nevertheless, there is not yet a consensus with regards to an optimal classification. Our study seeks to advance the existing binary definitions towards categorical/ordinal manifestations of disability. We define disability according to the WHO's International Classification of Functioning, Disability and Health (ICF) using data collected at the baseline wave of the English Longitudinal Study of Aging, a longitudinal study of the non-institutionalized population, living in England. First, we identify cut-off points in the continuous disability score derived from ICF to distinguish disabled from no-disabled participants. Then, we fit latent class models to the same data to find the optimal number of disability classes according to: (i) model fit indicators; (ii) estimated probabilities of each disability item; (iii) association of the predicted disability classes with observed health and mortality. According to the binary classification criteria, about 32% of both men and women are classified disabled. No optimal number of classes emerged from the latent class models according to model fit indicators. However, the other two criteria suggest that the best-fitting model of disability severity has four classes. Our findings contribute to the debate on the usefulness and relevance of adopting a finer categorization of disability, by showing that binary indicators of disability averaged the burden of disability and masked the very strong effect experienced by individuals having severe disability, and were not informative for low levels of disability. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  17. A Novel Method for Detection of Epilepsy in Short and Noisy EEG Signals Using Ordinal Pattern Analysis

    Directory of Open Access Journals (Sweden)

    Iman Veisi

    2010-03-01

    Full Text Available Introduction: In this paper, a novel complexity measure is proposed to detect dynamical changes in nonlinear systems using ordinal pattern analysis of time series data taken from the system. Epilepsy is considered as a dynamical change in nonlinear and complex brain system. The ability of the proposed measure for characterizing the normal and epileptic EEG signals when the signal is short or is contaminated with noise is investigated and compared with some traditional chaos-based measures. Materials and Methods: In the proposed method, the phase space of the time series is reconstructed and then partitioned using ordinal patterns. The partitions can be labeled using a set of symbols. Therefore, the state trajectory is converted to a symbol sequence. A finite state machine is then constructed to model the sequence. A new complexity measure is proposed to detect dynamical changes using the state transition matrix of the state machine. The proposed complexity measure was applied to detect epilepsy in short and noisy EEG signals and the results were compared with some chaotic measures. Results: The results indicate that this complexity measure can distinguish normal and epileptic EEG signals with an accuracy of more than 97% for clean EEG and more than 75% for highly noised EEG signals. Discussion and Conclusion: The complexity measure can be computed in a very fast and easy way and, unlike traditional chaotic measures, is robust with respect to noise corrupting the data. This measure is also capable of dynamical change detection in short time series data.

  18. Co-ordination of spark-gap protection with zinc-oxide surge arresters

    Energy Technology Data Exchange (ETDEWEB)

    Haddad, A.; German, D.M.; Waters, R.T. [Cardiff Univ., School of Engineering, Cardiff (United Kingdom); Abdul-Malek, Z. [University of Technology (Malaysia)

    2001-01-01

    Zinc-oxide (ZnO) surge arresters are now well established as a very efficient and reliable form of overvoltage protection against both fast surges, such as those generated by lightning and gas-insulated switchgear, and high-energy surges generated by switching operations and temporary faults on the network. The addition of ZnO surge arresters to existing protection schemes reinforces the system's reliability and the security of supply. The protection characteristics of the parallel configuration formed by arresters and existing spark gaps at distribution voltages are studied. Tests on various spark-gap geometries, with and without surge arresters in parallel, have been carried out to determine breakdown characteristics, probability curves and voltage-time characteristics for different impulse shapes. It is found that the introduction of the arrester in the circuit modifies the prospective impulse which results in the shift of the breakdown characteristics towards higher voltages. A proposed circuit model, based on laboratory test data, is used to simulate such parallel configurations. Good agreement between test and simulated results is obtained. As a result of these tests, it is recommended that gap-sparkover characteristics based on short-tail (about 5{mu}s) impulses are used for insulation co-ordination. The role of parallel airgaps in preserving the arrester energy-rating limits is also discussed. (Author)

  19. C5 Benchmark Problem with Discrete Ordinate Radiation Transport Code DENOVO

    Energy Technology Data Exchange (ETDEWEB)

    Yesilyurt, Gokhan [ORNL; Clarno, Kevin T [ORNL; Evans, Thomas M [ORNL; Davidson, Gregory G [ORNL; Fox, Patricia B [ORNL

    2011-01-01

    The C5 benchmark problem proposed by the Organisation for Economic Co-operation and Development/Nuclear Energy Agency was modeled to examine the capabilities of Denovo, a three-dimensional (3-D) parallel discrete ordinates (S{sub N}) radiation transport code, for problems with no spatial homogenization. Denovo uses state-of-the-art numerical methods to obtain accurate solutions to the Boltzmann transport equation. Problems were run in parallel on Jaguar, a high-performance supercomputer located at Oak Ridge National Laboratory. Both the two-dimensional (2-D) and 3-D configurations were analyzed, and the results were compared with the reference MCNP Monte Carlo calculations. For an additional comparison, SCALE/KENO-V.a Monte Carlo solutions were also included. In addition, a sensitivity analysis was performed for the optimal angular quadrature and mesh resolution for both the 2-D and 3-D infinite lattices of UO{sub 2} fuel pin cells. Denovo was verified with the C5 problem. The effective multiplication factors, pin powers, and assembly powers were found to be in good agreement with the reference MCNP and SCALE/KENO-V.a Monte Carlo calculations.

  20. Discrete ordinates transport methods for problems with highly forward-peaked scattering

    Energy Technology Data Exchange (ETDEWEB)

    Pautz, S.D.

    1998-04-01

    The author examines the solutions of the discrete ordinates (S{sub N}) method for problems with highly forward-peaked scattering kernels. He derives conditions necessary to obtain reasonable solutions in a certain forward-peaked limit, the Fokker-Planck (FP) limit. He also analyzes the acceleration of the iterative solution of such problems and offer improvements to it. He extends the analytic Fokker-Planck limit analysis to the S{sub N} equations. This analysis shows that in this asymptotic limit the S{sub N} solution satisfies a pseudospectral discretization of the FP equation, provided that the scattering term is handled in a certain way (which he describes) and that the analytic transport solution satisfies an analytic FP equation. Similar analyses of various spatially discretized S{sub N} equations reveal that they too produce solutions that satisfy discrete FP equations, given the same provisions. Numerical results agree with these theoretical predictions. He defines a multidimensional angular multigrid (ANMG) method to accelerate the iterative solution of highly forward-peaked problems. The analyses show that a straightforward application of this scheme is subject to high-frequency instabilities. However, by applying a diffusive filter to the ANMG corrections he is able to stabilize this method. Fourier analyses of model problems show that the resulting method is effective at accelerating the convergence rate when the scattering is forward-peaked. The numerical results demonstrate that these analyses are good predictors of the actual performance of the ANMG method.

  1. OPTIMIZATION OF LIME PRETREATMENT FOR ENZYMATIC SACCHARIFICATION OF WHEAT STRAW

    Directory of Open Access Journals (Sweden)

    Miroslav Ondrejovič

    2014-02-01

    Full Text Available The aim of this work was optimization of lime pretreatment parameters such as temperature, time and reaction ratio to maximization of reducing saccharide yields occurred by enzyme hydrolysis of pretreated plant material (wheat straw. Pretreatment conditions were optimized using response surface methodology. The optimal conditions were chosen to promote reducing saccharide yields following enzymatic digestion and they were temperature 91.5 °C, time 2.4 hours and reaction ratio 19.7 mL to 1 g of treated wheat straw. The experimental values agreed with predicted within a 95 % confidence interval. The computed model of wheat straw pretreatment by lime can be used for the effective utilization of secondary products obtained in agriculture sector.

  2. Spatial coding of ordinal information in short- and long-term memory

    Directory of Open Access Journals (Sweden)

    Veronique eGinsburg

    2015-01-01

    Full Text Available The processing of numerical information induces a spatial response bias: Faster responses to small numbers with the left hand and faster responses to large numbers with the right hand. Most theories agree that long-term representations underlie this so called SNARC effect (Spatial Numerical Association of Response Codes; Dehaene, Bossini, & Giraux, 1993. However, a spatial response bias was also observed with the activation of temporary position-space associations in working memory (ordinal position effect; van Dijck & Fias, 2011. Items belonging to the beginning of a memorized sequence are responded to faster with the left hand side while items at the end of the sequence are responded to faster with the right hand side. The theoretical possibility was put forward that the SNARC effect is an instance of the ordinal position effect, with the empirical consequence that the SNARC effect and the ordinal position effect cannot be observed simultaneously. In two experiments we falsify this claim by demonstrating that the SNARC effect and the ordinal position effect are not mutually exclusive. Consequently, this suggests that the SNARC effect and the ordinal position effect result from the activation of different representations. We conclude that spatial response biases can result from the activation of both pre-existing positions in long-term memory and from temporary space associations in working memory at the same time.

  3. Spatial coding of ordinal information in short- and long-term memory.

    Science.gov (United States)

    Ginsburg, Véronique; Gevers, Wim

    2015-01-01

    The processing of numerical information induces a spatial response bias: Faster responses to small numbers with the left hand and faster responses to large numbers with the right hand. Most theories agree that long-term representations underlie this so called SNARC effect (Spatial Numerical Association of Response Codes; Dehaene et al., 1993). However, a spatial response bias was also observed with the activation of temporary position-space associations in working memory (ordinal position effect; van Dijck and Fias, 2011). Items belonging to the beginning of a memorized sequence are responded to faster with the left hand side while items at the end of the sequence are responded to faster with the right hand side. The theoretical possibility was put forward that the SNARC effect is an instance of the ordinal position effect, with the empirical consequence that the SNARC effect and the ordinal position effect cannot be observed simultaneously. In two experiments we falsify this claim by demonstrating that the SNARC effect and the ordinal position effect are not mutually exclusive. Consequently, this suggests that the SNARC effect and the ordinal position effect result from the activation of different representations. We conclude that spatial response biases can result from the activation of both pre-existing positions in long-term memory and from temporary space associations in working memory at the same time.

  4. The Impact of the 2002 Delaware Smoking Ordinance on Heart Attack and Asthma

    Directory of Open Access Journals (Sweden)

    Luis H. Solis

    2010-12-01

    Full Text Available In the United States, smoking is the leading cause of death - having a mortality rate of approximately 435,000 people in 2000—accounting for 8.1% of all US deaths recorded that year. Consequently, we analyzed the Delaware Hospital Discharge Database, and identified state and non-state residents discharged with AMI or asthma for the years 1999 to 2004. Statistical data analysis compared the incidence of AMI or asthma for each group before (1999–2002 and after (2003–2004 the amendment. As a result, we found that pre-ordinance and post-ordinance quarterly rates of AMI for Delaware residents were 451 (se = 21 and 430 (se = 21 respectively, representing a 4.7% reduction. Over the same time period, there was negligible change in the incidence of AMI for non-Delaware residents. After adjusting for population growth, the Risk Ratio (RR for asthma in Delaware residents post-ordinance was 0.95 (95% CI, 0.90 to 0.999, which represented a significant reduction (P = 0.046. By comparison, non-Delaware residents had an increased RR for asthma post-ordinance of 1.62 (95% CI, 1.46 to 1.86; P < 0.0001.The results suggest that Delaware’s comprehensive non-smoking ordinance effectively was associated with a statistically significant decrease in the incidence of AMI and asthma in Delaware residents when compared to non-Delaware residents.

  5. Infants' development of object permanence: a refined methodology and new evidence of Piaget's hypothesized ordinality.

    Science.gov (United States)

    Kramer, J A; Hill, K T; Cohen, L B

    1975-03-01

    To investigate Piaget's theory of object concept development, a series of 6 tasks was administered in a combined longitudinal/cross-sectional design incorporating a number of methodological controls. The tasks spanned the entire sensorimotor period and included single versus sequential displacements combined with visible or invisible hidings. 36 infants from 5 to 32 months of age at initial testing were drawn equally from day-care and home settings. All infants received the 6 tasks during each of 3 testing sessions over a 6-month period. Clear evidence was obtained for task ordinality as proposed by Piaget, with ordinality coefficients ranging from .71 to .82 for the 3 testing sessions. Performance changes across the 3 sessions were also ordinal in 80% of the cases. Expected age, task, and session effects and accompanying interactions were also obtained.

  6. The validity of the pretreated, unilaterally MPTP-treated monkeys as a model of Parkinson's disease: a detailed behavioural analysis of the therapeutic and undesired effects of the D2 agonist quinpirole and the D1 agonist SKF 81297.

    Science.gov (United States)

    Andringa, G; Vermeulen, R J; Drukarch, B; Renier, W O; Stoof, J C; Cools, A R

    1999-03-01

    The goal of this study was to evaluate the validity of the pretreated, unilaterally MPTP-treated monkey as an animal model of Parkinson's disease (PD). For that purpose, a detailed ethogram was developed and assessed in four male rhesus monkeys that had received MPTP (2.5 mg) in the carotid artery contralateral to the dominant limb. Subsequently, the behavioural effects of the dopamine D2 agonist quinpirole and the dopamine D1 agonist SKF 81297 were studied. The ethogram was found to allow a clear-cut and objective separation of drug-induced behaviours into therapeutic and undesired effects in the MPTP-treated monkeys. Saline-treated monkeys predominantly displayed ipsilateral goal-directed fore-limb movements, and distinct types of ipsilaterally directed rotations. Although quinpirole and SKF 81297 increased motor behaviours, such as body displacement, contralateral fore-limb movements and contralateral rotational behaviours, assessment of the new detailed ethogram revealed that this increase was completely due to the activation of abnormal, non-goal-directed behaviours, such as dyskinetic fore-limb movements, pivoting and shuffling. Moreover, the new ethogram made clear that the drug treatments induced not only dyskinesia and dystonia, but also epileptoid behaviour, which was confirmed by EEG analysis. In summary, the detailed behavioural analysis showed that this model does not adequately predict the clinical effects of the D2 agonist. It is concluded that the pretreated, unilaterally MPTP-treated monkey is not a valid model to predict the therapeutic and undesired effects of dopaminergic drugs in humans.

  7. Introducing the Ordinance on energy efficiency labelling of household appliances on Croatian market

    Energy Technology Data Exchange (ETDEWEB)

    Kolega, Vesna [Energy institute Hrvoje Pozar, Zagreb (Croatia)

    2007-07-01

    The legal basis for the transposition of EU appliances labelling legislation in Croatia is the Energy law which Article 13 says: 'All electricity appliances have to be labelled by energy efficiency labels. The contents and design of energy efficiency labels have to be regulated by sub-law document called the Ordinance on Energy Efficiency Labelling of Households Appliances'. On 17th November 2005 the Ordinance on Energy Efficiency Labelling of Household Appliances entered into force. It is based on the Framework Directive 92/75/EEC and implementing Directives 94/2/EC, 95/12/EC, etc for the following appliances: refrigerators and freezers; washing machines; tumble driers; washing/drying machines; dishwashers; electrical ovens; electrical lamps; air-conditioners. Before 1st May 2006, in the majority of larger retail stores in Croatia, the energy efficiency labels were present on strictly voluntary basis. Such labels could be found mainly on refrigerators and freezers, washing machines, dryers and dishwashers. Recently, air-conditioners were also very often equipped with labels. These labels were correctly translated in Croatian, although text does not completely match the label defined in the Ordinance on Energy Efficiency Labelling of Household Appliances. Although such labels are not recognized as the appropriate labelling according the Ordinance, they do provide some practical basis for the implementation itself. Since 1st May 2006, although the Ordinance has been fully adopted, there are no valid Croatian labels attached on all displayed appliances in a number of HA stores. Aiming at household appliances market transformation in Croatia, it is very important at the moment to find the best ways for the Ordinance verification and enforcement.

  8. Biologically Pre-Treated Habitation Waste Water as a Sustainable Green Urine Pre-Treat Solution

    Science.gov (United States)

    Jackson, W. Andrew; Thompson, Bret; Sevanthi, Ritesh; Morse, Audra; Meyer, Caitlin; Callahan, Michael

    2017-01-01

    The ability to recover water from urine and flush water is a critical process to allow long term sustainable human habitation in space or bases on the moon or mars. Organic N present as urea or similar compounds can hydrolyze producing free ammonia. This reaction results in an increase in the pH converting ammonium to ammonia which is volatile and not removed by distillation. The increase in pH will also cause precipitation reactions to occur. In order to prevent this, urine on ISS is combined with a pretreat solution. While use of a pretreatment solution has been successful, there are numerous draw backs including: storage and use of highly hazardous solutions, limitations on water recovery (less than 85%), and production of brine with pore dewatering characteristics. We evaluated the use of biologically treated habitation wastewaters (ISS and early planetary base) to replace the current pretreat solution. We evaluated both amended and un-amended bioreactor effluent. For the amended effluent, we evaluated "green" pretreat chemicals including citric acid and citric acid amended with benzoic acid. We used a mock urine/air separator modeled after the urine collection assembly on ISS. The urine/air separator was challenged continually for >6 months. Depending on the test point, the separator was challenged daily with donated urine and flushed with amended or un-amended reactor effluent. We monitored the pH of the urine, flush solution and residual pH in the urine/air separator after each urine event. We also evaluated solids production and biological growth. Our results support the use of both un-amended and amended bioreactor effluent to maintain the operability of the urine /air separator. The ability to use bioreactor effluent could decrease consumable cost, reduce hazards associated with current pre-treat chemicals, allow other membrane based desalination processes to be utilized, and improve brine characteristics.

  9. Asymptotically Optimal Simulation Budget Allocation under Fixed Confidence Level by Ordinal Optimization

    Institute of Scientific and Technical Information of China (English)

    WANGJian-feng; SUNChun-Lin; CHENYong-qing

    2004-01-01

    Ordinal optimization concentrates on isolating a subset of good designs with high probability and reduces the required simulation time dramatically for discrete event simulation. To obtain the same probability level,we may optimally allocate our computing budget among different designs,instead of equally simulating all different designs. In this paper we present an effective approach to optimally allocate computing budget for discrete-event system simulation. While ordinal optimization can dramatically reduce the computation cost, our approach can further reduce the already-low cost.

  10. Pretreatment With Inactivated Bacillus Calmette-Guerin Increases CD4+CD25+ Regulatory T Cell Function and Decreases Functional and Structural Effects of Asthma Induction in a Rat Asthma Model.

    Science.gov (United States)

    Gong, Ping; Li, Yun; Tan, Yu-Pin; Li, Hong

    2016-04-01

    Bacillus Calmette-Guerin (BCG) has been shown to have therapeutic effects on asthma through CD4+CD25+ regulatory T cells (Tregs). We sought to assess pretreatment with inactivated BCG on CD4+CD25+ Tregs and its functional and structural effects in rat asthma model. The rat asthma model was established using ovalbumin (OVA) sensitization and challenge. Ten rats were pretreated with BCG prior to OVA and received continued BCG injections during OVA challenge (BCG+OVA group), 10 rats were treated with OVA alone (OVA group), and 10 rats were treated with saline (control group). After 9 weeks, histamine dihydrochloride effect on airway resistance was measured. Number of CD4+CD25+ Tregs was measured by flow cytometry, expression of Foxp3 and CTLA-4 mRNA was measured, and serum TGF-β levels were determined. Differential cell count in bronchoalveolar lavage fluid (BALF) was determined, and lung tissue was processed and stained with hematoxylin and eosin, Masson's trichrome, and alcine blue and periodic acid Schiff's reaction to evaluate inflammatory cell infiltration, collagen deposition, and presence of goblet cells, respectively. BCG treatment led to an increase in CD4+CD25+ Tregs, as well as an increase in Foxp3 and CTLA-4 expression and serum TGF-β levels. In addition, we observed a decrease in histamine dihydrochloride-induced airway resistance, a decrease in inflammatory leukocytes in BALF, and a decrease in airway remodeling indicators in BCG+OVA-treated rats compared with OVA-treated rats. Intradermally injected inactivated BCG has the potential to improve airway inflammation, airway resistance, and airway remodeling through a mechanism that may involve CD4+CD25+ Tregs. Copyright © 2015 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

  11. Thermochemical behavior of pretreated biomass

    Energy Technology Data Exchange (ETDEWEB)

    Biswas, Amit Kumar

    2011-07-01

    Mankind has to provide a sustainable alternative to its energy related problems. Bioenergy is considered as one of the potential renewable energy resources and as a result bioenergy market is also expected to grow dramatically in future. However, logistic issues are of serious concern while considering biomass as an alternative to fossil fuel. It can be improved by introducing pretreated wood pellet. The main objective of this thesis is to address thermochemical behaviour of steam exploded pretreated biomass. Additionally, process aspects of torrefaction were also considered in this thesis. Steam explosion (SE) was performed in a laboratory scale reactor using Salix wood chips. Afterwards, fuel and thermochemical aspects of SE residue were investigated. It was found that Steam explosion pretreatment improved both fuel and pellet quality. Pyrolysis of SE residue reveals that alerted biomass composition significantly affects its pyrolysis behaviour. Contribution from depolymerized components (hemicellulose, cellulose and lignin) of biomass was observed explicitly during pyrolysis. When devolatilization experiment was performed on pellet produced from SE residue, effect of those altered components was observed. In summary, pretreated biomass fuel characteristics is significantly different in comparison with untreated biomass. On the other hand, Process efficiency of torrefaction was found to be governed by the choice of appropriate operating conditions and the type of biomass.

  12. Numerical and Non-Numerical Ordinality Processing in Children with and without Developmental Dyscalculia: Evidence from fMRI

    Science.gov (United States)

    Kaufmann, L.; Vogel, S. E.; Starke, M.; Kremser, C.; Schocke, M.

    2009-01-01

    Ordinality is--beyond numerical magnitude (i.e., quantity)--an important characteristic of the number system. There is converging empirical evidence that (intra)parietal brain regions mediate number magnitude processing. Furthermore, recent findings suggest that the human intraparietal sulcus (IPS) supports magnitude and ordinality in a…

  13. Amendment of the Ordinance on Hazardous Substances (GefStoffV); Novellierung der Gefahrstoffverordnung (GefStoffV)

    Energy Technology Data Exchange (ETDEWEB)

    Henrici, R.; Boehrer, R. [Bundesfachschule Kaelte-Klima-Technik, Maintal (Germany)

    2005-08-01

    The new Ordinance on Hazardous Materials (GefStoffV)came into force on 1 January 2005. The amendment was necessary for implementing European law (98/24/EG) into German law. The Ordinance states goals and specifies requirements on safety and health protection when handling hazardous materials. (orig.)

  14. Errata to the Werts-Linn Comments on Boyle's "Path Analysis and Ordinal Data."

    Science.gov (United States)

    Werts, Charles E.; Linn, Robert L.

    The Werts-Linn procedure for dealing with categorical errors of measurement in "Comments on Boyle's 'Path Analysis and Ordinal Data'" in The American Journal of Sociology, volume 76, number 6, May 1971, is shown to be inappropriate to the problem of ordered categories. (For related document, see TM 002 301.) (DB)

  15. 75 FR 23289 - Ponca Tribe of Indians of Oklahoma Liquor Control Ordinance

    Science.gov (United States)

    2010-05-03

    ... brewed liquor or of wine by any Person to any Person and also includes giving away Liquor, Wine, Beer, or... ``Liquor'' as herein defined in this Ordinance. (b) ``Beer'' means any beverage obtained by the alcoholic... percent of Alcohol by weight shall be referred to as ``strong Beer.'' (c) ``Gaming Facility'' means a...

  16. Educating Leaders for Social Justice: The Case of Special Educational Needs Co-Ordinators

    Science.gov (United States)

    Liasidou, Anastasia; Svensson, Cathy

    2014-01-01

    In the light of policy imperatives to initiate and maintain inclusive education reforms, the role of special educational needs co-ordinators (SENCOs) in England and Wales should be reconceptualised with a view to their leading school reforms commensurate with the principles of an inclusive discourse. The article concentrates on the social justice…

  17. Pelvic organ prolapse symptoms in relation to POPQ, ordinal stages and ultrasound prolapse assessment.

    NARCIS (Netherlands)

    Kluivers, K.B.; Hendriks, J.C.M.; Shek, C.; Dietz, H.P.

    2008-01-01

    Adequate staging of pelvic organ prolapse is important in clinical practice and research. The ability of the POPQ, ordinal stages and ultrasound prolapse assessment were evaluated for their ability to discriminate between women with and without prolapse symptoms. The leading edge of the predominant

  18. The Standards Agenda: Reflections of a Special Educational Needs Co-ordinator

    Science.gov (United States)

    Glazzard, Jonathan

    2014-01-01

    This study is a life history account of Bev, a special educational needs co-ordinator who works in a primary school in England. The research examines how, within Bev's experiences, the discourses of integration and inclusion have affected learners with special educational needs. Additionally, the study examines the impact of the…

  19. Emerging Adulthood in Developmental Co-Ordination Disorder: Parent and Young Adult Perspectives

    Science.gov (United States)

    Kirby, A.; Edwards, L.; Sugden, D.

    2011-01-01

    Recent research widely acknowledges that developmental co-ordination disorder (DCD) is a pervasive and enduring disorder, which persists into adolescence and adulthood ([Cousins and Smyth, 2003] and [Kirby et al., 2008]). However, few studies have given detailed consideration to the range and level of functioning difficulties in emerging adults…

  20. Developmental Co-Ordination Disorder (DCD) in Adolescents and Adults in Further and Higher Education

    Science.gov (United States)

    Kirby, Amanda; Sugden, David; Beveridge, Sally; Edwards, Lisa

    2008-01-01

    Few studies have looked at the strengths and weaknesses and needs of students with developmental co-ordination disorder (DCD). This paper describes a cohort of 93 UK students currently studying at further or higher education and who have reported motor difficulties present since childhood. The study group consisted of 21 reporting to have DCD…

  1. 78 FR 14352 - Notice of Approved Class III Tribal Gaming Ordinances

    Science.gov (United States)

    2013-03-05

    ... Indians of California 59. Crow Creek Sioux Tribe 60. Crow Indian Tribe of Montana 61. Delaware Tribe of... National Indian Gaming Commission Notice of Approved Class III Tribal Gaming Ordinances AGENCY: National Indian Gaming Commission. ACTION: Notice. SUMMARY: The purpose of this notice is to inform the public of...

  2. 75 FR 62853 - Reno-Sparks Indian Colony Liquor Control Ordinance

    Science.gov (United States)

    2010-10-13

    ...-Mart Superstore to sell liquor on tribal lands, which will general millions of dollars in sales revenue and increase funding for essential government services provided by the Reno-Sparks Indian Colony. The ordinance will increase the ability of the tribal government to control the distribution and possession of...

  3. A psicose ordinária e os fenômenos de corpo

    Directory of Open Access Journals (Sweden)

    Márcia Rosa

    2009-03-01

    Full Text Available Este artigo retoma as formulações lacanianas dos anos 50 sobre a psicose, psicose freudiana à la Schreber, e aquelas outras dos anos 1970, propostas a partir do sinthoma joyciano, de modo a discutir uma nova denominação surgida contemporaneamente, a psicose ordinária, e o modo como ela trata o corpo.

  4. Supply Chain Co-ordination and Industry Clockspeed: an Exploratory Study

    NARCIS (Netherlands)

    Voordijk, Hans; Akkermans, Henk; Meijboom, Bert

    2003-01-01

    The increasing velocity of change, or clockspeed, in the business environment is a key challenge for firms and industries nowadays. In this study, the impact of industry and organisation clockspeed on specific mechanisms used for supply chain co-ordination is investigated from an information-process

  5. The Design Co-ordination Framework: key elements for effective product development

    DEFF Research Database (Denmark)

    Andreasen, Mogens Myrup; Bowen, J.; Storm, T.

    1997-01-01

    , organisation, allocations, tasks etc. during the design process, has been identified. Each frame is explained and the co-ordination, i.e. the management of the links between these frames, is presented, based upon characteristic DC situations in Industry. It is concluded that while the DCF provides a basis...

  6. The midwives ordinance of Palestine, 1929: historical perspectives and current lessons.

    Science.gov (United States)

    Katvan, Eyal; Bartal, Nira

    2010-06-01

    Until 1929, midwifery in Palestine was relatively open to anyone and only partially regulated by the 1918 Public Health Ordinance, legislated shortly after the beginning of British rule. This article describes the factors that guided the shaping of midwifery and suggests possible sources of inspiration for the British legislator in crafting the Midwives Ordinance in 1929, including American, local (Jews and Arabs), and British ones. The Midwives Ordinance reflects the adjustment of midwifery to changes in the society that evolved under the British Mandate. The ordinance shows how the modern midwife's role contracted relative to the traditional one, in the context of social processes in other countries, east and west. This historical research project is based on interviews, archive documents and research literature. It analyzes the British interests in regulating midwifery, including the rationale of preserving public health and reducing infant mortality, against a background of political power struggles as well as cultural, social and professional diversity in Palestine (the tensions between the powers of doctors, nurses, and pharmacists).

  7. Using two-level factor analysis to test for cluster bias in ordinal data.

    NARCIS (Netherlands)

    Jak, Suzanne; Oort, F.J .; Dolan, Conor V.

    2014-01-01

    The test for cluster bias is a test of measurement invariance across clusters in 2-level data. This article examines the true positive rates (empirical power) and false positive rates of the test for cluster bias using the likelihood ratio test (LRT) and the Wald test with ordinal data. A simulation

  8. 75 FR 22419 - Liquor Control Ordinance of the Prairie Band Potawatomi Nation

    Science.gov (United States)

    2010-04-28

    ... establishments, public buildings, public meeting halls, lobbies, halls and dining room of hotels, restaurants... and attorneys fees and take any other actions reasonably necessary to carry out this ordinance... from time to time by the Tribal Council for this purpose. Said application must be filled...

  9. The Standards Agenda: Reflections of a Special Educational Needs Co-ordinator

    Science.gov (United States)

    Glazzard, Jonathan

    2014-01-01

    This study is a life history account of Bev, a special educational needs co-ordinator who works in a primary school in England. The research examines how, within Bev's experiences, the discourses of integration and inclusion have affected learners with special educational needs. Additionally, the study examines the impact of the…

  10. Pretreatment on Anaerobic Sludge for Enhancement of Biohydrogen Production from Cassava Processing Wastewater

    Directory of Open Access Journals (Sweden)

    Franciele do Carmo Lamaison

    2014-02-01

    Full Text Available Methods for the enrichment of an anaerobic sludge with H2-producing bacteria have been compared by using cassava processing wastewater as substrate.The sludge was submitted to three different pretreatments: 1 heat pretreatment by boiling at 98 °C for 15 min., 2 heat pretreatment followed by sludge washout in a Continuous Stirring Tank Reactor (CSTR operated at a dilution rate (D of 0.021 h-1, and 3 sludge washout as the sole enrichment method. The pretreated sludge and the sludge without pretreatment (control were employed in the seeding of 4 batch bioreactors, in order to verify the volume and composition of the generated biogas. Maximum H2 production rates (Rm from the pretreated sludges, were estimated by the modified Gompertz model. Compared to the control, H2 production was ca. 4 times higher for the sludge submitted to the heat pretreatment only and for the sludge subjected to heat pretreatment combined with washout, and 10 times higher for washout. These findings demonstrated that the use of sludge washout as the sole sludge pretreatment method was the most effective in terms of H2 production, as compared to the heat and to the combined heat and washout pretreatments.

  11. Biorefining of wheat straw: accounting for the distribution of mineral elements in pretreated biomass by an extended pretreatment – severity equation

    DEFF Research Database (Denmark)

    Le, Duy Michael; Sørensen, Hanne Risbjerg; Knudsen, Niels Ole;

    2014-01-01

    Background: Mineral elements present in lignocellulosic biomass feedstocks may accumulate in biorefinery process streams and cause technological problems, or alternatively can be reaped for value addition. A better understanding of the distribution of minerals in biomass in response to pretreatme...... fiber fractions. A new expanded pretreatment-severity equation is proposed to model and predict mineral composition in pretreated wheat straw biomass...... factors is therefore important in relation to development of new biorefinery processes. The objective of the present study was to examine the levels of mineral elements in pretreated wheat straw in response to systematic variations in the hydrothermal pretreatment parameters (pH, temperature......, and treatment time), and to assess whether it is possible to model mineral levels in the pretreated fiber fraction. Results: Principal component analysis of the wheat straw biomass constituents, including mineral elements, showed that the recovered levels of wheat straw constituents after different hydrothermal...

  12. Rheological evaluation of pretreated cladding removal waste

    Energy Technology Data Exchange (ETDEWEB)

    McCarthy, D.; Chan, M.K.C.; Lokken, R.O.

    1986-01-01

    Cladding removal waste (CRW) contains concentrations of transuranic (TRU) elements in the 80 to 350 nCi/g range. This waste will require pretreatment before it can be disposed of as glass or grout at Hanford. The CRW will be pretreated with a rare earth strike and solids removal by centrifugation to segregate the TRU fraction from the non-TRU fraction of the waste. The centrifuge centrate will be neutralized with sodium hydroxide. This neutralized cladding removal waste (NCRW) is expected to be suitable for grouting. The TRU solids removed by centrifugation will be vitrified. The goal of the Rheological Evaluation of Pretreated Cladding Removal Waste Program was to evaluate those rheological and transport properties critical to assuring successful handling of the NCRW and TRU solids streams and to demonstrate transfers in a semi-prototypic pumping environment. This goal was achieved by a combination of laboratory and pilot-scale evaluations. The results obtained during these evaluations were correlated with classical rheological models and scaled-up to predict the performance that is likely to occur in the full-scale system. The Program used simulated NCRW and TRU solid slurries. Rockwell Hanford Operations (Rockwell) provided 150 gallons of simulated CRW and 5 gallons of simulated TRU solid slurry. The simulated CRW was neutralized by Pacific Northwest Laboratory (PNL). The physical and rheological properties of the NCRW and TRU solid slurries were evaluated in the laboratory. The properties displayed by NCRW allowed it to be classified as a pseudoplastic or yield-pseudoplastic non-Newtonian fluid. The TRU solids slurry contained very few solids. This slurry exhibited the properties associated with a pseudoplastic non-Newtonian fluid.

  13. Comparison of different pretreatments for the production of bioethanol and biomethane from corn stover and switchgrass.

    Science.gov (United States)

    Papa, G; Rodriguez, S; George, A; Schievano, A; Orzi, V; Sale, K L; Singh, S; Adani, F; Simmons, B A

    2015-05-01

    In this study the efficiency of mild ionic liquid (IL) pretreatment and pressurized hot water (PHW) is evaluated and compared in terms of bioethanol and biomethane yields, with corn stover (CS) and switchgrass (SG) as model bioenergy crops. Both feedstocks pretreated with the IL 1-ethyl-3-methylimidazolium acetate [C2C1Im][OAc] at 100°C for 3h exhibited lower glucose yield that those treated with harsher pretreatment conditions previously used. Compared to PHW, IL pretreatment demonstrated higher bioethanol yields; moreover IL pretreatment enhanced biomethane production. Taking into consideration both bioethanol and biomethane productions, results indicated that when using IL pretreatment, the total energy produced per kg of total solids was higher compared to untreated biomasses. Specifically energy produced from CS and SG was +18.6% and +34.5% respectively, as compared to those obtained by hot water treatment, i.e. +2.3% and +23.4% for CS and SG, respectively.

  14. Solids Control in Sludge Pretreatment

    Energy Technology Data Exchange (ETDEWEB)

    Beahm, E.C., Weber, C.F., Hunt, R.D., Dillow, T.A.

    1997-12-31

    Sludge pretreatment will likely involve washing, followed by caustic or acidic leaching and washing of sludge residues after leaching. The principal goal of pretreatment is to obtain a low-volume high-activity waste stream and a high-volume low-activity waste stream. Also, some waste constituents such as chromium and phosphate can be included in glass formulations only at very low concentrations; therefore, it is desirable to remove them from high-level waste streams. Two aspects of sludge treatment and subsequent separations should be well delineated and predictable: (1) the distribution of chemical species between aqueous solutions and solids and (2) potential problems due to chemical interactions that could result in process difficulties or safety concerns.Before any treatment technology is adopted, it must be demonstrated that the process can be carried out as planned. Three pretreatment methods were considered in the Tri-Party (Washington State Ecology, U.S. Environmental Protection Agency, and U.S. Department of Energy) negotiations: (1) sludge washing with corrosion- inhibiting water, (2) Enhanced Sludge Washing, and (3)acidic dissolution with separations processes. Enhanced Sludge Washing is the baseline process. In Enhanced Sludge Washing, sludge is first washed with corrosion-inhibiting water; it is then leached with caustic (sodium hydroxide solution) and washed again with corrosion- inhibiting water. The initial concern is whether a pretreatment technique is effective in separating sludge components. This can be evaluated by bench-scale tests with sludge specimens from underground storage tanks. The results give data on the distribution of important species such as aluminum, phosphate, and radionuclides between wash and leach solutions and solid sludge residues.

  15. Effect of propofol pretreatment on apoptosis in rat brain cortex after focal cerebral ischemia and reperfusion

    Institute of Scientific and Technical Information of China (English)

    Haiyan Xu; Chengwei Zhang; Chunxiao Zhang

    2011-01-01

    The present study aimed to observe cortical expression of Bcl-2 and Bax, cysteine-dependent aspartate directed proteases-3 activity and apoptotic cell death in a rat model of middle cerebral artery occlusion pretreated with propofol. Results showed that, propofol pretreatment significantly reduced oxidative stress levels and attenuated neuronal apoptosis in the cortex of rats. Propofol pretreatment upregulated Bcl-2 expression, and downregulated Bax expression and cysteine-dependent aspartate directed proteases-3 activity. These findings indicate that propofol pretreatment inhibits cell apoptosis during focal cerebral ischemia/reperfusion injury. This neuroprotective effect is most likely achieved through the Bcl-2/Bax/cysteine-dependent aspartate directed proteases-3 pathway.

  16. Dilute Acid and Autohydrolysis Pretreatment

    Science.gov (United States)

    Yang, Bin; Wyman, Charles E.

    Exposure of cellulosic biomass to temperatures of about 120-210°C can remove most of the hemicellulose and produce cellulose-rich solids from which high glucose yields are possible with cellulase enzymes. Furthermore, the use of dilute sulfuric acid in this pretreatment operation can increase recovery of hemicellulose sugars substantially to about 85-95% of the maximum possible versus only about 65% if no acid is employed. The use of small-diameter tubes makes it possible to employ high solids concentrations similar to those preferred for commercial operations, with rapid heat-up, good temperature control, and accurate closure of material balances. Mixed reactors can be employed to pretreat larger amounts of biomass than possible in such small-diameter tubes, but solids concentrations are limited to about 15% or less to provide uniform temperatures. Pretreatment of large amounts of biomass at high solids concentrations is best carried out using direct steam injection and rapid pressure release, but closure of material balances in such “steam gun” devices is more difficult. Although flow of water alone or containing dilute acid is not practical commercially, such flow-through configurations provide valuable insight into biomass deconstruction kinetics not possible in the batch tubes, mixed reactors, or steam gun systems.

  17. Multiple treatment comparisons in a series of anti-malarial trials with an ordinal primary outcome and repeated treatment evaluations

    Directory of Open Access Journals (Sweden)

    Youdom Solange

    2012-05-01

    Full Text Available Abstract Background Artemisinin-based combination therapies (ACT are widely used in African countries, including Cameroon. Between 2005 and 2007, five randomized studies comparing different treatment arms among artesunate-amodiaquine and other ACT were conducted in Cameroonian children aged two to 60 months who had uncomplicated Plasmodium falciparum malaria. In these studies, the categorical criterion proposed by the World Health Organization (WHO to assess the relative effectiveness of anti-malarial drugs was repeatedly evaluated on Days 14, 21 and 28 after treatment initiation. The aim of the present study was to compare the effects of different treatments on this repeated ordinal outcome, hence using the fully available information. Methods The quantitative synthesis was based on individual patient data. Due to the incomplete block design concerning treatment arms between different trials, a mixed treatment comparison (MTC meta-analysis approach was adopted. The repeated ordinal outcome was modelled through a latent variable, as a proportional odds mixed model with trial, period and treatment arms as covariates. The model was further complexified to account for the variance heterogeneity, and the individual log-residual variance was modelled as a linear mixed model, as well. The effects of individual covariates at inclusion, such as parasitaemia, fever, gender and weight, were also tested. Model parameters were estimated using a Bayesian approach via the WinBUGS software. After selecting the best model using Deviance Information Criterion (DIC, mixed treatment comparisons were based on the estimated treatment effects. Results Modeling the residual variance improved the model ability to adjust the data. The results showed that, compared to artesunate-amodiaquine (ASAQ, dihydroartemisinin-piperaquine (DHPP was significantly more efficacious. Artesunate-chlorproguanil-dapsone (ASCD was less efficacious than artesunate

  18. Pretreatment of moso bamboo with dilute phosphoric acid

    Directory of Open Access Journals (Sweden)

    Bo Hong

    2012-11-01

    Full Text Available Dilute phosphoric acid pretreatment of moso bamboo materials was studied for producing high quality dissolving pulp for textile applications. The dynamics of dilute acid pretreatment were considered. The Saeman model was found to describe well the acid hydrolysis of moso bamboo hemicelluloses to their monomers under different temperatures and different dilute phosphoric acid concentrations. The initial degradation rate of hemicelluloses was much higher than its subsequent degradation rate, and the xylose generation rate increased with increasing temperature. The change rule of the pentose extraction rate was considered along with the pretreatment factor (P factor. Optimum dilute acid pretreatment conditions were 170 °C and 45 minutes. Based on the optimum conditions and a mass balance of sugars, a weight loss of 26.5% of the solid and liquid fractions combined was observed after the pretreatment. SEM results revealed that the moso bamboo fibers surfaces and cell wall were damaged. With the surface area increasing, the accessible pore areas also increased. At the same time, the crystallinity of the cellulose was reduced, which created a favorable environment for chemical penetration in the subsequent treatment.

  19. Identification of a cis-regulatory element by transient analysis of co-ordinately regulated genes

    Directory of Open Access Journals (Sweden)

    Allan Andrew C

    2008-07-01

    Full Text Available Abstract Background Transcription factors (TFs co-ordinately regulate target genes that are dispersed throughout the genome. This co-ordinate regulation is achieved, in part, through the interaction of transcription factors with conserved cis-regulatory motifs that are in close proximity to the target genes. While much is known about the families of transcription factors that regulate gene expression in plants, there are few well characterised cis-regulatory motifs. In Arabidopsis, over-expression of the MYB transcription factor PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT 1 leads to transgenic plants with elevated anthocyanin levels due to the co-ordinated up-regulation of genes in the anthocyanin biosynthetic pathway. In addition to the anthocyanin biosynthetic genes, there are a number of un-associated genes that also change in expression level. This may be a direct or indirect consequence of the over-expression of PAP1. Results Oligo array analysis of PAP1 over-expression Arabidopsis plants identified genes co-ordinately up-regulated in response to the elevated expression of this transcription factor. Transient assays on the promoter regions of 33 of these up-regulated genes identified eight promoter fragments that were transactivated by PAP1. Bioinformatic analysis on these promoters revealed a common cis-regulatory motif that we showed is required for PAP1 dependent transactivation. Conclusion Co-ordinated gene regulation by individual transcription factors is a complex collection of both direct and indirect effects. Transient transactivation assays provide a rapid method to identify direct target genes from indirect target genes. Bioinformatic analysis of the promoters of these direct target genes is able to locate motifs that are common to this sub-set of promoters, which is impossible to identify with the larger set of direct and indirect target genes. While this type of analysis does not prove a direct interaction between protein and DNA

  20. Assessment of Shock Pretreatment of Corn Stover Using the Carboxylate Platform.

    Science.gov (United States)

    Darvekar, Pratik; Holtzapple, Mark T

    2016-03-01

    Corn stover was pretreated with lime and shock, a mechanical process that uses a shockwave to alter the biomass structure. Two pretreatments (lime-only and lime + shock) were evaluated using enzymatic hydrolysis, batch mixed-culture fermentations, and continuous countercurrent mixed-culture fermentation. In a 120-h enzymatic hydrolysis, shock pretreatment increased the glucan digestibility of submerged lime pretreatment (SLP) corn stover by 3.5 % and oxidative lime pretreatment (OLP) corn stover by 2.5 %. The continuum particle distribution model (CPDM) was used to simulate a four-stage continuous countercurrent mixed-culture fermentation using empirical rate models obtained from simple batch experiments. The CPDM model determined that lime + shock pretreatment increased the total carboxylic acids yield by 28.5 % over lime-only pretreatment in a countercurrent fermentation with a volatile solids loading rate (VSLR) of 12 g/(L/day) and liquid retention time (LRT) of 30 days. In a semi-continuous countercurrent fermentation performed in the laboratory for 112 days with a VSLR of 1.875 g/(L day) and LRT of 16 days, lime + shock pretreatment increased the total carboxylic acid yield by 14.8 %. The experimental results matched closely with CPDM model predictions (4.05 % error).

  1. Quantification of errors in ordinal outcome scales using shannon entropy: effect on sample size calculations.

    Directory of Open Access Journals (Sweden)

    Pitchaiah Mandava

    Full Text Available OBJECTIVE: Clinical trial outcomes often involve an ordinal scale of subjective functional assessments but the optimal way to quantify results is not clear. In stroke, the most commonly used scale, the modified Rankin Score (mRS, a range of scores ("Shift" is proposed as superior to dichotomization because of greater information transfer. The influence of known uncertainties in mRS assessment has not been quantified. We hypothesized that errors caused by uncertainties could be quantified by applying information theory. Using Shannon's model, we quantified errors of the "Shift" compared to dichotomized outcomes using published distributions of mRS uncertainties and applied this model to clinical trials. METHODS: We identified 35 randomized stroke trials that met inclusion criteria. Each trial's mRS distribution was multiplied with the noise distribution from published mRS inter-rater variability to generate an error percentage for "shift" and dichotomized cut-points. For the SAINT I neuroprotectant trial, considered positive by "shift" mRS while the larger follow-up SAINT II trial was negative, we recalculated sample size required if classification uncertainty was taken into account. RESULTS: Considering the full mRS range, error rate was 26.1%±5.31 (Mean±SD. Error rates were lower for all dichotomizations tested using cut-points (e.g. mRS 1; 6.8%±2.89; overall p<0.001. Taking errors into account, SAINT I would have required 24% more subjects than were randomized. CONCLUSION: We show when uncertainty in assessments is considered, the lowest error rates are with dichotomization. While using the full range of mRS is conceptually appealing, a gain of information is counter-balanced by a decrease in reliability. The resultant errors need to be considered since sample size may otherwise be underestimated. In principle, we have outlined an approach to error estimation for any condition in which there are uncertainties in outcome assessment. We

  2. The immune response of rainbow trout to Flavobacterium psychrophilum following immersion-challenge model with and without hydrogen peroxide pre-treatment

    DEFF Research Database (Denmark)

    Henriksen, Maya Maria Mihályi; Madsen, Lone; Kania, P. W.;

    2013-01-01

    , no commercial vaccine is currently available and the disease is treated with antibiotics. Injection-based challenges with F. psychrophilum are standardized but the route of infection does not reflect a natural situation. Therefore, we established an immersion-based model investigating if hydrogen peroxide (H2O2...

  3. Parametric Dose Standardization for Optimizing Two-Agent Combinations in a Phase I-II Trial with Ordinal Outcomes.

    Science.gov (United States)

    Thall, Peter F; Nguyen, Hoang Q; Zinner, Ralph G

    2017-01-01

    A Bayesian model and design are described for a phase I-II trial to jointly optimise the doses of a targeted agent and a chemotherapy agent for solid tumors. A challenge in designing the trial was that both the efficacy and toxicity outcomes were defined as four-level ordinal variables. To reflect possibly complex joint effects of the two doses on each of the two outcomes, for each marginal distribution a generalised continuation ratio model was assumed, with each agent's dose parametrically standardised in the linear term. A copula was assumed to obtain a bivariate distribution. Elicited outcome probabilities were used to construct a prior, with variances calibrated to obtain small prior effective sample size. Elicited numerical utilities of the 16 elementary outcomes were used to compute posterior mean utilities as criteria for selecting dose pairs, with adaptive randomisation to reduce the risk of getting stuck at a suboptimal pair. A simulation study showed that parametric dose standardisation with additive dose effects provides a robust, reliable model for dose pair optimisation in this setting, and it compares favourably with designs based on alternative models that include dose-dose interaction terms. The proposed model and method are applicable generally to other clinical trial settings with similar dose and outcome structures.

  4. Use and Misuse of the Likert Item Responses and Other Ordinal Measures.

    Science.gov (United States)

    Bishop, Phillip A; Herron, Robert L

    Likert, Likert-type, and ordinal-scale responses are very popular psychometric item scoring schemes for attempting to quantify people's opinions, interests, or perceived efficacy of an intervention and are used extensively in Physical Education and Exercise Science research. However, these numbered measures are generally considered ordinal and violate some statistical assumptions needed to evaluate them as normally distributed, parametric data. This is an issue because parametric statistics are generally perceived as being more statistically powerful than non-parametric statistics. To avoid possible misinterpretation, care must be taken in analyzing these types of data. The use of visual analog scales may be equally efficacious and provide somewhat better data for analysis with parametric statistics.

  5. Measuring information interactions on the ordinal pattern of stock time series.

    Science.gov (United States)

    Zhao, Xiaojun; Shang, Pengjian; Wang, Jing

    2013-02-01

    The interactions among time series as individual components of complex systems can be quantified by measuring to what extent they exchange information among each other. In many applications, one focuses not on the original series but on its ordinal pattern. In such cases, trivial noises appear more likely to be filtered and the abrupt influence of extreme values can be weakened. Cross-sample entropy and inner composition alignment have been introduced as prominent methods to estimate the information interactions of complex systems. In this paper, we modify both methods to detect the interactions among the ordinal pattern of stock return and volatility series, and we try to uncover the information exchanges across sectors in Chinese stock markets.

  6. Optimization of prostate cancer treatment plans using the adjoint transport method and discrete ordinates codes

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, S.; Henderson, D.L. [Dept. of Medical Physics, Madison, WI (United States); Thomadsen, B.R. [Dept. of Medical Physics and Dept. of Human Oncology, Madison (United States)

    2001-07-01

    Interstitial brachytherapy is a type of radiation in which radioactive sources are implanted directly into cancerous tissue. Determination of dose delivered to tissue by photons emitted from implanted seeds is an important step in the treatment plan process. In this paper we will investigate the use of the discrete ordinates method and the adjoint method to calculate absorbed dose in the regions of interest. MIP (mixed-integer programming) is used to determine the optimal seed distribution that conforms the prescribed dose to the tumor and delivers minimal dose to the sensitive structures. The patient treatment procedure consists of three steps: (1) image acquisition with the transrectal ultrasound (TRUS) and assessing the region of interest, (2) adjoint flux computation with discrete ordinate code for inverse dose calculation, and (3) optimization with the MIP branch-and-bound method.

  7. Co-ordinating innate and adaptive immunity to viral infection: mobility is the key

    DEFF Research Database (Denmark)

    Wern, Jeanette Erbo; Thomsen, Allan Randrup

    2009-01-01

    The host counters a viral infection through a complex response made up of components belonging to both the innate and the adaptive immune system. In this report, we review the mechanisms underlying this response, how it is induced and how it is co-ordinated. As cell-cell communication represents...... in mounting an efficient host response and co-ordinating innate and adaptive immunity during a primary viral infection....... the very essence of immune system physiology, a key to a rapid, efficient and optimally regulated immune response is the ability of the involved cells to rapidly shift between a stationary and a mobile state, combined with stringent regulation of cell migration during the mobile state. Through the co...

  8. Method for pretreating lignocellulosic biomass

    Science.gov (United States)

    Kuzhiyil, Najeeb M.; Brown, Robert C.; Dalluge, Dustin Lee

    2015-08-18

    The present invention relates to a method for pretreating lignocellulosic biomass containing alkali and/or alkaline earth metal (AAEM). The method comprises providing a lignocellulosic biomass containing AAEM; determining the amount of the AAEM present in the lignocellulosic biomass; identifying, based on said determining, the amount of a mineral acid sufficient to completely convert the AAEM in the lignocellulosic biomass to thermally-stable, catalytically-inert salts; and treating the lignocellulosic biomass with the identified amount of the mineral acid, wherein the treated lignocellulosic biomass contains thermally-stable, catalytically inert AAEM salts.

  9. Inferring long memory processes in the climate network via ordinal pattern analysis

    CERN Document Server

    Barreiro, Marcelo; Masoller, Cristina

    2010-01-01

    We use ordinal patterns and symbolic analysis to construct global climate networks and uncover long and short term memory processes. The data analyzed is the monthly averaged surface air temperature (SAT field) and the results suggest that the time variability of the SAT field is determined by patterns of oscillatory behavior that repeat from time to time, with a periodicity related to intraseasonal oscillations and to El Ni\\~{n}o on seasonal-to-interannual time scales.

  10. Human responses to Florida red tides: policy awareness and adherence to local fertilizer ordinances.

    Science.gov (United States)

    Kirkpatrick, Barbara; Kohler, Kate; Byrne, Margaret; Fleming, Lora E; Scheller, Karen; Reich, Andrew; Hitchcock, Gary; Kirkpatrick, Gary; Ullmann, Steven; Hoagland, Porter

    2014-09-15

    To mitigate the damages of natural hazards, policy responses can be beneficial only if they are effective. Using a self-administered survey approach, this paper focuses on the adherence to local fertilizer ordinances (i.e., county or municipal rules regulating the application of fertilizer to private lawns or facilities such as golf courses) implemented in jurisdictions along the Southwest Florida coast in response to hazardous blooms of Florida red tides (Karenia brevis). These ordinances play a role in the context of evolving programs of water pollution control at federal, state, water basin, and local levels. With respect to policy effectiveness, while the strength of physical linkages is of critical importance, the extent to which humans affected are aware of and adhere to the relevant rules, is equally critical. We sought to understand the public's depth of understanding about the rationales for local fertilizer ordinances. Respondents in Sarasota, Florida, were asked about their fertilizer practices in an area that has experienced several major blooms of Florida red tides over the past two decades. A highly educated, older population of 305 residents and "snowbirds" reported relatively little knowledge about a local fertilizer ordinance, its purpose, or whether it would change the frequency, size, or duration of red tides. This finding held true even among subpopulations that were expected to have more interest in or to be more knowledgeable about harmful algal blooms. In the face of uncertain science and environmental outcomes, and with individual motivations at odds with evolving public policies, the effectiveness of local community efforts to decrease the impacts of red tides may be compromised. Targeted social-science research on human perceptions about the risks of Florida red tides and education about the rationales for potential policy responses are warranted.

  11. Discrete Ordinates Approximations to the First- and Second-Order Radiation Transport Equations

    CERN Document Server

    Fan, W C; Powell, J L

    2002-01-01

    The conventional discrete ordinates approximation to the Boltzmann transport equation can be described in a matrix form. Specifically, the within-group scattering integral can be represented by three components: a moment-to-discrete matrix, a scattering cross-section matrix and a discrete-to-moment matrix. Using and extending these entities, we derive and summarize the matrix representations of the second-order transport equations.

  12. School-teachers awareness of developmental co-ordination delay (DCD) in children

    OpenAIRE

    2011-01-01

    non-peer-reviewed Background: Developmental Co-ordination Delay (DCD) is estimated to affect 5-6% of school children (1). School-teachers play an integral role in noting delayed signs of motor development in children (2). Limited research has been carried out investigating the awareness that Irish school-teachers demonstrate of DCD. Objectives: To determine the awareness that Irish primary school-teachers have of DCD, in children. Methods: Qualitative methodology involving three focus grou...

  13. Using the Analytic Hierarchy Process to Derive Health State Utilities from Ordinal Preference Data.

    Science.gov (United States)

    Reddy, Brian P; Adams, Roisin; Walsh, Cathal; Barry, Michael; Kind, Paul

    2015-09-01

    The EuroQol five-dimensional questionnaire is a standardized instrument used in the economic evaluation of health care to measure health state preferences across disease groups. A time trade-off (TTO) approach is commonly used to elicit preferences from the public. However, there are issues regarding how best to measure worse-than-dead states; at present, extreme valuations are rounded up to more acceptable values. TTO elicitation is also cognitively demanding for respondents and is therefore expensive to investigate. To describe how the analytic hierarchy process approach could be used to generate utilities from the ordinal relationships between the health states instead of the ordinal relationships between health states, allowing potentially useful preference data to be incorporated rather than excluded as they are at present. It was applied to the Measurement and Valuation of Health study data set, measuring health state preferences for the United Kingdom. The analytic hierarchy process approach was explained. Five approaches to structure pairwise comparisons of health state preference were described (two concave, two convex, and one linear). All approaches described predicted the rankings of health states well. However, utilities derived followed an unconventional, bunched shape compared with the original Measurement and Valuation of Health TTO study. An approach was identified by optimizing the parameters, minimizing the sum of squared errors between the ordinal "health state ranking" approach and the original TTO-derived utilities. This approach outlined offers the potential to convert ordinal preference data into cardinal utilities. It is simpler than TTO studies to carry out and removes the need to directly alter results of the preference ranking exercise. Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  14. Recovery of lactic acid from the pretreated fermentation broth based on a novel hyper-cross-linked meso-micropore resin: Modeling.

    Science.gov (United States)

    Song, Mingkai; Jiao, Pengfei; Qin, Taotao; Jiang, Kangkang; Zhou, Jingwei; Zhuang, Wei; Chen, Yong; Liu, Dong; Zhu, Chenjie; Chen, Xiaochun; Ying, Hanjie; Wu, Jinglan

    2017-10-01

    An innovative benign process for recovery lactic acid from its fermentation broth is proposed using a novel hyper-cross-linked meso-micropore resin and water as eluent. This work focuses on modeling the competitive adsorption behaviors of glucose, lactic acid and acetic acid ternary mixture and explosion of the adsorption mechanism. The characterization results showed the resin had a large BET surface area and specific pore structure with hydrophobic properties. By analysis of the physicochemical properties of the solutes and the resin, the mechanism of the separation is proposed as hydrophobic effect and size-exclusion. Subsequently three chromatographic models were applied to predict the competitive breakthrough curves of the ternary mixture under different operating conditions. The pore diffusion was the major limiting factor for the adsorption process, which was consistent with the BET results. The novel HD-06 resin can be a good potential adsorbent for the future SMB continuous separation process. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Fermi co-ordinates and relativistic effects in non-inertial frames

    CERN Document Server

    Nikolic, H

    2000-01-01

    Fermi co-ordinates are proper co-ordinates of a local observer determined by his trajectory in space-time. Two observers at different positions belong to different Fermi frames even if there is no relative motion between them. Use of Fermi co-ordinates leads to several physical conclusions related to relativistic effects seen by observers in arbitrary motion. In flat space-time, the relativistic length seen by an observer depends only on his instantaneous velocity, not on his acceleration or rotation. In arbitrary space-time, for any observer the velocity of light is isotropic and equal to $c$, provided that it is measured by propagating a light beam in a small neighbourhood of the observer. The value of a covariant field measured at the position of the observer depends only on his instantaneous position and velocity, not on his acceleration. The notion of radiation is observer independent. A "freely" falling charge in curved space-time does not move along a geodesic and therefore radiates.

  16. Serial learning with wild card items by monkeys (Cebus apella): implications for knowledge of ordinal position.

    Science.gov (United States)

    D'Amato, M R; Colombo, M

    1989-09-01

    We investigated monkeys' knowledge of the ordinal positions of stimuli that formed a 5-item serial list, ABCDE, by means of wild card items (W) that could substitute for items in the original series. In Experiment 1, training with wild cards was given on 3-, 4-, and 5-item series. In the last of these series, the wild card substitutions created five wild card sequences, WBCDE through ABCDW. During the final 10 sessions of training with each of two different wild cards (Items x and Y), the 3 subjects were able to successfully complete almost 60% of the wild card sequences. In Experiment 2, the two wild cards were presented on the same trial in 10 different double wild card sequences (e.g., AXCDY). The 2 monkey subjects correctly completed about 59% of the double wild card sequences during the final two training sessions. The performance levels achieved on single and on double wild card sequences, although well below that observed on the baseline sequence ABCDE (90% or better), support the view that the monkeys possessed some knowledge regarding the ordinal position of each baseline item. Consequently, an associative chain interpretation, which does not provide for knowledge of ordinal position, falls short as a complete account of the monkey's capacity for serial learning.

  17. UNQUESTIONED GENDER LENS IN CONTEMPORARY INDONESIAN SHARI‘A ORDINANCES (PERDA SYARI’AH

    Directory of Open Access Journals (Sweden)

    Dewi Candraningrum

    2007-08-01

    Full Text Available Indonesian Muslim participation in the democratic arena is now contested with the arrival of the decentralization process in 423 districts since 1992. The most notable movement is the quest for Islamic identity in the rejuvenation of Shari‘ah Ordinances which is interpreted symbolically and transcripturally. These ordinances have unrecognized the importance of gender lens in its practice. Until the end of 2007 no less than 63 districts have ratified Perda Syari’ah. In general, these ordinances designed to govern three aspects of public life, namely (1 to eradicate social crimes especially prostitutions and gambling; (2 to enforce ritual observances among Muslims such as reading the Qur’an, Friday congregations and fasting during Ramadhan; and (3 to govern the way people dress up in public sphere—especially the head-veiling for women. Although Islam is the religion of the majority there are also non-Muslim among Indonesian and institutionally Indonesia is not an Islamic state, therefore the ratification of Perda Syari’ah betrayed national consensus agreed upon by the founding fathers of the republic.

  18. A HISTORICAL REVIEW OF HIGHWAY PLANNING AND DESIGN POLICY IN "COMMENTARY ON JAPANESE ROAD STRUCTURE ORDINANCE"

    Science.gov (United States)

    Morita, Hirohisa

    The "Commentary on Japanese Road Structure Ordinance" is a book which narrates the "Japanese Road Structure Ordinance" and was revised three times from the original version published in 1960. This paper puts together and formulates the progress and interpretation of hitory of each revision. The main results derived are as below; the thought of road design is changed from the intent of national uniformity of road structures at the beginning to the flexible application of the ordinance regulations for suitable road design for the regional condition recently; hierarchy in road classification is not clear so that the target level of service and the methodology in design are not fully established yet; the contradiction caused in the treatment of demand and capacity as daily volume should be dissolved; and it is needed that the establishment of new proper standards of lane width, design speed, and so on in road design or traffic operation through confirmation of the course and conotation of the such standards setting.

  19. Process and technoeconomic analysis of leading pretreatment technologies for lignocellulosic ethanol production using switchgrass.

    Science.gov (United States)

    Tao, Ling; Aden, Andy; Elander, Richard T; Pallapolu, Venkata Ramesh; Lee, Y Y; Garlock, Rebecca J; Balan, Venkatesh; Dale, Bruce E; Kim, Youngmi; Mosier, Nathan S; Ladisch, Michael R; Falls, Matthew; Holtzapple, Mark T; Sierra, Rocio; Shi, Jian; Ebrik, Mirvat A; Redmond, Tim; Yang, Bin; Wyman, Charles E; Hames, Bonnie; Thomas, Steve; Warner, Ryan E

    2011-12-01

    Six biomass pretreatment processes to convert switchgrass to fermentable sugars and ultimately to cellulosic ethanol are compared on a consistent basis in this technoeconomic analysis. The six pretreatment processes are ammonia fiber expansion (AFEX), dilute acid (DA), lime, liquid hot water (LHW), soaking in aqueous ammonia (SAA), and sulfur dioxide-impregnated steam explosion (SO(2)). Each pretreatment process is modeled in the framework of an existing biochemical design model so that systematic variations of process-related changes are consistently captured. The pretreatment area process design and simulation are based on the research data generated within the Biomass Refining Consortium for Applied Fundamentals and Innovation (CAFI) 3 project. Overall ethanol production, total capital investment, and minimum ethanol selling price (MESP) are reported along with selected sensitivity analysis. The results show limited differentiation between the projected economic performances of the pretreatment options, except for processes that exhibit significantly lower monomer sugar and resulting ethanol yields.

  20. Cell expansion not cell differentiation predominantly co-ordinates veins and stomata within and among herbs and woody angiosperms grown under sun and shade.

    Science.gov (United States)

    Carins Murphy, Madeline R; Jordan, Gregory J; Brodribb, Timothy J

    2016-11-01

    It has been proposed that modification of leaf size, driven by epidermal cell size, balances leaf water supply (determined by veins) with transpirational demand (generated by stomata) during acclimation to local irradiance. We aimed to determine whether this is a general pattern among plant species with contrasting growth habits. We compared observed relationships between leaf minor vein density, stomatal density, epidermal cell size and leaf size in four pairs of herbs and woody species from the same families grown under sun and shade conditions with modelled relationships assuming vein and stomatal densities respond passively to epidermal cell expansion. Leaf lignin content was also quantified to assess whether construction costs of herbaceous leaf veins differ from those of woody plants and the leaf mass fraction invested in veins. Modelled relationships accurately described observed relationships, indicating that in all species, co-ordinated changes to the density of minor veins and stomata were mediated by a common relationship between epidermal cell size, vein density and stomatal density, with little or no impact from stomatal index. This co-ordination was independent of changes in leaf size and is likely to be an adaptive process driven by the significant proportion of biomass invested in veins (13·1 % of sun leaf dry weight and 21·7 % of shade leaf dry weight). Relative costs of venation increased in the shade, intensifying selective pressure towards economizing investment in vein density. Modulation of epidermal cell size appears to be a general mechanism among our experimental species to maintain a constant ratio between leaf anatomical traits that control leaf water fluxes independently of habit. We propose that this process may co-ordinate plasticity in hydraulic supply and demand in the majority of eudicot angiosperms. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For

  1. New Drugs for Pretreatment of Organophosphonate Intoxication

    Science.gov (United States)

    1990-02-20

    COPY A D L£> SRI PROJECT PYU-4681 NEW DRUGS FOR PRETREATMENT OF ORGANOPHOSPHONATE INTOXICATION FINAL REPORT AD-B145 250 Daniel W. Parish, Allen...BB WORK UNIT ACCESSION NO. 099 11. TITLE (indud* Security Oaofficattofl) New Drugs for Pretreatment of Organophosphonate Intoxication...undertaken for the U.S. Army Medical Research and Development Command (MRDC) under Contract DAMD17-88-C-8001, " New Drugs for Pretreatment of

  2. Variable discrete ordinates method for radiation transfer in plane-parallel semi-transparent media with variable refractive index

    Science.gov (United States)

    Sarvari, S. M. Hosseini

    2017-09-01

    The traditional form of discrete ordinates method is applied to solve the radiative transfer equation in plane-parallel semi-transparent media with variable refractive index through using the variable discrete ordinate directions and the concept of refracted radiative intensity. The refractive index are taken as constant in each control volume, such that the direction cosines of radiative rays remain non-variant through each control volume, and then, the directions of discrete ordinates are changed locally by passing each control volume, according to the Snell's law of refraction. The results are compared by the previous studies in this field. Despite simplicity, the results show that the variable discrete ordinate method has a good accuracy in solving the radiative transfer equation in the semi-transparent media with arbitrary distribution of refractive index.

  3. GA Based Clustering of Mixed Data Type of Attributes (Numeric, Categorical, Ordinal, Binary and Ratio-Scaled)

    National Research Council Canada - National Science Library

    Rohit Rastogi; Pinki Mondal; Kritika Agarwal; Rachit Gupta;

    2015-01-01

    .... Data mining and data clustering, the prominent field of today it is a highly desirable task to apply unsupervised classification analysis on high volume of data sets with combined ordinal, ratio...

  4. Tax revenue in Mississippi communities following implementation of smoke-free ordinances: an examination of tourism and economic development tax revenues.

    Science.gov (United States)

    McMillen, Robert; Shackelford, Signe

    2012-10-01

    There is no safe level of exposure to tobacco smoke. More than 60 Mississippi communities have passed smoke-free ordinances in the past six years. Opponents claim that these ordinances harm local businesses. Mississippi law allows municipalities to place a tourism and economic development (TED) tax on local restaurants and hotels/motels. The objective of this study is to examine the impact of these ordinances on TED tax revenues. This study applies a pre/post quasi-experimental design to compare TED tax revenue before and after implementing ordinances. Descriptive analyses indicated that inflation-adjusted tax revenues increased during the 12 months following implementation of smoke-free ordinances while there was no change in aggregated control communities. Multivariate fixed-effects analyses found no statistically significant effect of smoke-free ordinances on hospitality tax revenue. No evidence was found that smoke-free ordinances have an adverse effect on the local hospitality industry.

  5. Influence of Limitations on Possible Graph Ordinate Values of Electrical Load on Rated Values of Load Peaks and Troughs

    Directory of Open Access Journals (Sweden)

    I. V. Zhezhelenko

    2006-01-01

    Full Text Available The influence of limitations on possible theta-ordinate values of group non-uniform electrical load graphs on the rated values of theta peaks and theta troughs and, particularly, on the rated heating load value is considered in the paper. It is shown that neglect of limitations on graph theta- ordinates of an electrical load leads in some cases to errors in evaluation of load theta peaks and theta troughs that exceed the tolerable values by ±10 %.

  6. Methodology to resolve the transport equation with the discrete ordinates code TORT into the IPEN/MB-01 reactor

    OpenAIRE

    Bernal García, Álvaro; Abarca Giménez, Agustín; Barrachina Celda, Teresa María; Miró Herrero, Rafael

    2014-01-01

    This is an Accepted Manuscript of an article published by Taylor & Francis in International Journal of Computer Mathematics in 2014, available online: http://www.tandfonline.com/10.1080/00207160.2013.799668 Resolution of the steady-state Neutron Transport Equation in a nuclear pool reactor is usually achieved by means of two different numerical methods: Monte Carlo (stochastic) and Discrete Ordinates (deterministic). The Discrete Ordinates method solves the Neutron Transport Equation for a...

  7. Impact of San Francisco’s Toy Ordinance on Restaurants and Children’s Food Purchases, 2011–2012

    Science.gov (United States)

    Saelens, Brian E.; Kapphahn, Kristopher I.; Hekler, Eric B.; Buman, Matthew P.; Goldstein, Benjamin A.; Krukowski, Rebecca A.; O’Donohue, Laura S.; Gardner, Christopher D.; King, Abby C.

    2014-01-01

    Introduction In 2011, San Francisco passed the first citywide ordinance to improve the nutritional standards of children’s meals sold at restaurants by preventing the giving away of free toys or other incentives with meals unless nutritional criteria were met. This study examined the impact of the Healthy Food Incentives Ordinance at ordinance-affected restaurants on restaurant response (eg, toy-distribution practices, change in children’s menus), and the energy and nutrient content of all orders and children’s-meal–only orders purchased for children aged 0 through 12 years. Methods Restaurant responses were examined from January 2010 through March 2012. Parent–caregiver/child dyads (n = 762) who were restaurant customers were surveyed at 2 points before and 1 seasonally matched point after ordinance enactment at Chain A and B restaurants (n = 30) in 2011 and 2012. Results Both restaurant chains responded to the ordinance by selling toys separately from children’s meals, but neither changed their menus to meet ordinance-specified nutrition criteria. Among children for whom children’s meals were purchased, significant decreases in kilocalories, sodium, and fat per order were likely due to changes in children’s side dishes and beverages at Chain A. Conclusion Although the changes at Chain A did not appear to be directly in response to the ordinance, the transition to a more healthful beverage and default side dish was consistent with the intent of the ordinance. Study results underscore the importance of policy wording, support the concept that more healthful defaults may be a powerful approach for improving dietary intake, and suggest that public policies may contribute to positive restaurant changes. PMID:25032837

  8. Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model.

    Science.gov (United States)

    Gremonprez, Félix; Descamps, Benedicte; Izmer, Andrei; Vanhove, Christian; Vanhaecke, Frank; De Wever, Olivier; Ceelen, Wim

    2015-10-06

    Cytoreductive surgery combined with intraperitoneal chemotherapy (IPC) is currently the standard treatment for selected patients with peritoneal carcinomatosis of colorectal cancer. However, especially after incomplete cytoreduction, disease progression is common and this is likely due to limited tissue penetration and efficacy of intraperitoneal cytotoxic drugs. Tumor microenvironment-targeting drugs, such as VEGF(R) and PDGFR inhibitors, can lower the heightened interstitial fluid pressure in tumors, a barrier to drug delivery. Here, we investigated whether tumor microenvironment-targeting drugs enhance the effectiveness of intraperitoneal chemotherapy. A mouse xenograft model with two large peritoneal implants of colorectal cancer cells was developed to study drug distribution and tumor physiology during intraperitoneal Oxaliplatin perfusion. Mice were treated for six days with either Placebo, Imatinib (anti-PDGFR, daily), Bevacizumab (anti-VEGF, twice) or Pazopanib (anti-PDGFR, -VEGFR; daily) followed by intraperitoneal oxaliplatin chemotherapy. Bevacizumab and Pazopanib significantly lowered interstitial fluid pressure, increased Oxaliplatin penetration (assessed by laser ablation inductively coupled plasma mass spectrometry) and delayed tumor growth of peritoneal implants (assessed by MRI). Our findings suggest that VEGF(R)-inhibition may improve the efficacy of IPC, particularly for patients for whom a complete cytoreduction might not be feasible.

  9. Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury.

    Science.gov (United States)

    Xu, Shen; Chen, Yuan-Hua; Tan, Zhu-Xia; Xie, Dong-Dong; Zhang, Cheng; Xia, Mi-Zhen; Wang, Hua; Zhao, Hui; Xu, De-Xiang; Yu, De-Xin

    2015-08-01

    Increasing evidence demonstrates that reactive oxygen species plays important roles in sepsis-induced acute kidney injury. This study investigated the effects of VitD3 pretreatment on renal oxidative stress in sepsis-induced acute kidney injury. Mice were intraperitoneally injected with lipopolysaccharide (LPS, 2.0mg/kg) to establish an animal model of sepsis-induced acute kidney injury. In VitD3+LPS group, mice were orally pretreated with three doses of VitD3 (25 μg/kg) at 1, 24 and 48 h before LPS injection. As expected, oral pretreatment with three daily recommended doses of VitD3 markedly elevated serum 25(OH)D concentration and efficiently activated renal VDR signaling. Interestingly, LPS-induced renal GSH depletion and lipid peroxidation were markedly alleviated in VitD3-pretreated mice. LPS-induced serum and renal nitric oxide (NO) production was obviously suppressed by VitD3 pretreatment. In addition, LPS-induced renal protein nitration, as determined by 3-nitrotyrosine residue, was obviously attenuated by VitD3 pretreatment. Further analysis showed that LPS-induced up-regulation of renal inducible nitric oxide synthase (inos) was repressed in VitD3-pretreated mice. LPS-induced up-regulation of renal p47phox and gp91phox, two NADPH oxidase subunits, were normalized by VitD3 pretreatment. In addition, LPS-induced down-regulation of renal superoxide dismutase (sod) 1 and sod2, two antioxidant enzyme genes, was reversed in VitD3-pretreated mice. Finally, LPS-induced tubular epithelial cell apoptosis, as determined by TUNEL, was alleviated by VitD3 pretreatment. Taken together, these results suggest that VitD3 pretreatment alleviates LPS-induced renal oxidative stress through regulating oxidant and antioxidant enzyme genes.

  10. Wash water waste pretreatment system

    Science.gov (United States)

    1977-01-01

    Investigations were completed on wash waters based on each candidate personal cleansing agent. Evaluations of coagulants, antifoam agents, and the effect of promising antifoams on the chemical precipitation were included. Based on these evaluations two candidate soaps as well as their companion antifoam agents were selected for further work. Operating parameters included the effect of soap concentration, ferric chloride concentration, duration of mixing, and pore size of depth filters on the degree of soap removal. The effect of pressure on water flow through filter cartridges and on the rate of decline of water flow was also investigated. The culmination of the program was the recommendation of a pretreatment concept based on chemical precipitation followed by pressure filtration.

  11. The Lueneburg model - experience from a one-year operating period of the mechanic-biological waste pre-treatment plant; Modell Lueneburg - Erfahrungen aus einem Jahr Betrieb der MBV-Anlage

    Energy Technology Data Exchange (ETDEWEB)

    Tegtmeyer, E. [Gesellschaft fuer Abfallwirtschaft Lueneburg mbH, Bardowick (Germany)

    1997-12-31

    The Lueneburg plant is one of three demonstration plants for mechanic-biological pre-treatment of residual waste which receive considerable grants from the state of Niedersachsen. Whereas the other two plants, the one at Bassum (district of Diepholz) and the one at Wiefels (district of Friesland), are currently under construction, the Lueneburg plant has been officially inaugurated already in December 1995 and has since been in operation. (orig./SR) [Deutsch] Die Lueneburger Anlage ist eine von drei Demonstrationsanlagen zur mechanisch-biologischen Vorbehandlung von Restabfaellen, die durch das Land Niedersachsen in erheblichem Umfang anteilig gefoerdert werden. Waehrend die beiden anderen Anlagen in Bassum (Landkreis Diepholz) und Wiefels (Landkreis Friesland) sich zur Zeit in der Errichtungsphase befinden, ist die MBV-Anlage Lueneburg bereits im Dezember 1995 offiziell eingeweiht worden und verfuegt damit mittlerweile ueber eine etwa einjaehrige Betriebserfahrung. (orig./SR)

  12. pH catalyzed pretreatment of corn bran for enhanced enzymatic arabinoxylan degradation

    DEFF Research Database (Denmark)

    Agger, Jane; Johansen, Katja Salomon; Meyer, Anne S.

    2011-01-01

    Corn bran is mainly made up of the pericarp of corn kernels and is a byproduct stream resulting from the wet milling step in corn starch processing. Through statistic modeling this study examined the optimization of pretreatment of corn bran for enzymatic hydrolysis. A low pH pretreatment (pH 2......, 150°C, 65min) boosted the enzymatic release of xylose and glucose and maximized biomass solubilization. With more acidic pretreatment followed by enzymatic hydrolysis the total xylose release was maximized (at pH 1.3) reaching ∼50% by weight of the original amount present in destarched corn bran......, but the enzyme catalyzed xylose release was maximal after pretreatment at approx. pH 2. The total glucose release peaked after pretreatment of approx. pH 1.5 with an enzymatic release of approx. 68% by weight of the original amounts present in destarched corn bran. For arabinose the enzymatic release...

  13. Microwave Pretreatment For Hydrolysis Of Cellulose

    Science.gov (United States)

    Cullingford, Hatice S.; George, Clifford E.; Lightsey, George R.

    1993-01-01

    Microwave pretreatment enhances enzymatic hydrolysis of cellulosic wastes into soluble saccharides used as feedstocks for foods, fuels, and other products. Low consumption of energy, high yield, and low risk of proposed hydrolysis process incorporating microwave pretreatment makes process viable alternative to composting.

  14. Impact analysis of different chemical pre-treatments on colour of apple discs during drying process

    OpenAIRE

    D. Magdić; Lukinac, Jasmina; Jokić, Stela; Čačić-Kenjerić, F.; Bilić, M.; Velić, D.

    2009-01-01

    The main purpose of this study was to compare colour changes of chemically pre-treated dried apple discs. Changes were observed by chromameter in L*a*b* colour model by using Minolta chromameter CR-400 and by image analysis system in RGB colour model. Apple discs variety "Gold Rush" were pre-treated and dried in laboratory tray drier at drying temperature 70 °C and at airflow velocity of 1.5 ms-1. Different chemical pre-treatments were applied on apple discs (dipping in 0.5% ascorbic acid sol...

  15. The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis.

    Science.gov (United States)

    Zhang, Ting; Gao, Wenjing; Cao, Weihua; Zhan, Siyan; Lv, Jun; Pang, Zengchang; Wang, Shaojie; Chen, Rongfu; Hu, Yonghua; Li, Liming

    2012-08-01

    Though multiple policies have been implemented, the cigarette control in China is still facing a great challenge. At the same time, alcohol drinking has increasingly become a public health problem. Considering cigarette smoking and alcohol drinking often co-occur, a few studies tested the covariance of these phenotypes. However, the genetic and environmental correlation between them among Chinese population has not been determined. The main aim of this study is to fill this gap. From the Chinese National Twin Registry, we obtained the data on cigarette smoking and alcohol drinking behaviors. The ordinal bivariate genetic analysis was performed to fit the categorical variables. After identifying the best decomposition among the Cholesky, common, and independent pathway model, we established the most parsimonious submodel. The correlation between current tobacco and alcohol use could be explained by Cholesky model. The shared environmental variances for both phenotypes were dropped to construct the most parsimonious submodel. Furthermore, the most parsimonious submodel showed a moderate correlation (0.32, 95%CI=0.17-0.46) between the genetic components and a negligible non-shared environmental correlation. As the first bivariate genetic analysis on current tobacco smoking and current alcohol drinking in China, this study suggested a common genetic vulnerability to tobacco and alcohol use in male twins. Further studies should be carried out to track the pertinent genes that are related to the comorbidity of smoking and drinking in Chinese population. Another urgent need is to recognize the behavior-specific environmental risk factors.

  16. Kinetics of lime pretreatment of sugarcane bagasse to enhance enzymatic hydrolysis.

    Science.gov (United States)

    Fuentes, Laura L G; Rabelo, Sarita C; Filho, Rubens Maciel; Costa, Aline C

    2011-03-01

    The objective of this work was to determine the optimum conditions of sugarcane bagasse pretreatment with lime to increase the enzymatic hydrolysis of the polysaccharide component and to study the delignification kinetics. The first stage was an evaluation of the influence of temperature, reaction time, and lime concentration in the pretreatment performance measured as glucose release after hydrolysis using a 2(3) central composite design and response surface methodology. The maximum glucose yield was 228.45 mg/g raw biomass, corresponding to 409.9 mg/g raw biomass of total reducing sugars, with the pretreatment performed at 90°C, for 90 h, and with a lime loading of 0.4 g/g dry biomass. The enzymes loading was 5.0 FPU/dry pretreated biomass of cellulase and 1.0 CBU/dry pretreated biomass of β-glucosidase. Kinetic data of the pretreatment were evaluated at different temperatures (60°C, 70°C, 80°C, and 90°C), and a kinetic model for bagasse delignification with lime as a function of temperature was determined. Bagasse composition (cellulose, hemicellulose, and lignin) was measured, and the study has shown that 50% of the original material was solubilized, lignin and hemicellulose were selectively removed, but cellulose was not affected by lime pretreatment in mild temperatures (60-90°C). The delignification was highly dependent on temperature and duration of pretreatment.

  17. Reuse of microalgae grown in full-scale wastewater treatment ponds: Thermochemical pretreatment and biogas production.

    Science.gov (United States)

    Passos, Fabiana; Felix, Leonardo; Rocha, Hemyle; Pereira, Jackson de Oliveira; de Aquino, Sérgio

    2016-06-01

    This study assessed thermochemical pretreatment of microalgae harvested from a full-scale wastewater treatment pond prior to its anaerobic digestion using acid and alkaline chemical doses combined with thermal pretreatment at 80°C. Results indicated that alkaline and thermal pretreatment contributed mostly to glycoprotein and pectin solubilisation; whilst acid pretreatment solubilised mostly hemicellulose, with lower effectiveness for proteins. Regarding the anaerobic biodegradability, biochemical methane potential (BMP) tests showed that final methane yield was enhanced after almost all pretreatment conditions when compared to non-pretreated microalgae, with the highest increase for thermochemical pretreatment at the lowest dose (0.5%), i.e. 82% and 86% increase for alkaline and acid, respectively. At higher doses, salt toxicity was revealed by K(+) concentrations over 5000mg/L. All BMP data from pretreated biomass was successfully described by the modified Gompertz model and optimal condition (thermochemical 0.5% HCl) showed an increase in final methane yield and the process kinetics. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. A real explosion: the requirement of steam explosion pretreatment.

    Science.gov (United States)

    Yu, Zhengdao; Zhang, Bailiang; Yu, Fuqiang; Xu, Guizhuan; Song, Andong

    2012-10-01

    The severity factor is a common term used in steam explosion (SE) pretreatment that describes the combined effects of the temperature and duration of the pretreatment. However, it ignores the duration of the explosion process. This paper describes a new parameter, the explosion power density (EPD), which is independent of the severity factor. Furthermore, we present the adoption of a 5m(3) SE model for a catapult explosion mode, which completes the explosion within 0.0875 s. The explosion duration ratio of this model to a conventional model of the same volume is 1:123. The comparison between the two modes revealed a qualitative change by explosion speed, demonstrating that this real explosion satisfied the two requirements of consistency, and suggested a guiding mechanism for the design of SE devices.

  19. Innovative pretreatment strategies for biogas production.

    Science.gov (United States)

    Patinvoh, Regina J; Osadolor, Osagie A; Chandolias, Konstantinos; Sárvári Horváth, Ilona; Taherzadeh, Mohammad J

    2017-01-01

    Biogas or biomethane is traditionally produced via anaerobic digestion, or recently by thermochemical or a combination of thermochemical and biological processes via syngas (CO and H2) fermentation. However, many of the feedstocks have recalcitrant structure and are difficult to digest (e.g., lignocelluloses or keratins), or they have toxic compounds (such as fruit flavors or high ammonia content), or not digestible at all (e.g., plastics). To overcome these challenges, innovative strategies for enhanced and economically favorable biogas production were proposed in this review. The strategies considered are commonly known physical pretreatment, rapid decompression, autohydrolysis, acid- or alkali pretreatments, solvents (e.g. for lignin or cellulose) pretreatments or leaching, supercritical, oxidative or biological pretreatments, as well as combined gasification and fermentation, integrated biogas production and pretreatment, innovative biogas digester design, co-digestion, and bio-augmentation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Aqueous ionic liquid pretreatment of straw.

    Science.gov (United States)

    Fu, Dongbao; Mazza, Giuseppe

    2011-07-01

    Pretreatment is the key to unlock the recalcitrance of lignocellulose for cellulosic biofuels production. Increasing attention has been drawn to ionic liquids (ILs) for pretreatment of lignocellulosic biomass, because this approach has several advantages over conventional methods. However, cost and energy-intensive recycling of the solvents are major constraints preventing ILs from commercial viability. In this work, a mixture of ionic liquid 1-ethyl-3-methylimidazolium acetate and water was demonstrated to be effective for pretreatment of lignocellulosic biomass, evidenced by the removal of lignin and a reduction in cellulose crystallinity. A higher fermentable sugar yield (81%) was obtained than for pure ionic liquid pretreatment under the same conditions (67%). Aqueous ionic liquid pretreatment has the advantages of less usage and easier recycling of ILs, and reduced viscosity. Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

  1. Gadolinium chloride pretreatment ameliorates acute cadmium-induced hepatotoxicity.

    Science.gov (United States)

    Kyriakou, Loukas G; Tzirogiannis, Konstantinos N; Demonakou, Maria D; Kourentzi, Kalliopi T; Mykoniatis, Michael G; Panoutsopoulos, Georgios I

    2013-08-01

    Cadmium is a known industrial and environmental pollutant. It causes hepatotoxicity upon acute administration. Features of cadmium-induced acute hepatoxicity encompass necrosis, apoptosis, peliosis and inflammatory infiltration. Gadolinium chloride (GdCl3) may prevent cadmium-induced hepatotoxicity by suppressing Kupffer cells. The effect of GdCl3 pretreatment on a model of acute cadmium-induced liver injury was investigated. Male Wistar rats 4-5 months old were injected intraperitoneally with normal saline followed by cadmium chloride (CdCl2; 6.5 mg/kg) or GdCl3 (10 mg/kg) followed by CdCl2 (6.5 mg/kg; groups I and II, respectively). Rats of both the groups were killed at 9, 12, 16, 24, 48 and 60 h after cadmium intoxication. Liver sections were analyzed for necrosis, apoptosis, peliosis and mitoses. Liver regeneration was also evaluated by tritiated thymidine incorporation into hepatic DNA. Serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were also determined. Hepatic necrosis, hepatocyte and nonparenchymal cell apoptosis and macroscopic and microscopic types of peliosis hepatis were minimized by gadolinium pretreatment. Serum levels of AST and ALT were also greatly diminished in rats of group II. Tritiated thymidine incorporation into hepatic DNA was increased in gadolinium pretreatment rats. Kupffer cell activation was minimal in both the groups of rats. Gadolinium pretreatment attenuates acute cadmium-induced liver injury in young Wistar rats, with mechanisms other than Kupffer cell elimination.

  2. Thermochemical Pretreatment for Anaerobic Digestion of Sorted Waste

    Science.gov (United States)

    Hao, W.; Hongtao, W.

    2008-02-01

    The effect of alkaline hydrothermal pre-treatment for anaerobic digestion of mechanically-sorted municipal solid waste (MSW) and source-sorted waste was studied. Waste was hydrothermally pre-treated in dilute alkali solution. Hydrolysis product was incubated in 500 ml saline bottle to determine methane potential (MP) under mesospheric anaerobic conditions. Optimum reaction condition obtained in the study is 170 °C at the dose of 4 g NaOH/100 g solid for one hour. Soluble COD was 13936 mg/L and methane yield was 164 ml/g VS for 6 days incubation at optimum conditions. More than 50% biogas increase was achieved over the control, and methane conversion ratio on carbon basis was enhanced to 30.6%. The digestion period was less than 6 days when pre-treatment temperature was above 130 °C. The organic part of sorted waste is mainly constituted of kitchen garbage and leaf. Model kitchen garbage was completely liquidized at 130 °C for one hour and the methane yield was 276 ml/g VS. Addition of alkali enhance hydroxylation rate and methane yield slightly. The biogas potential of leaf could be observed by pre-treatment above 150 °C under alkaline condition.

  3. Case study of attempts to enact self service tobacco display ordinances: a tale of three communities

    Science.gov (United States)

    Bidell, M.; Furlong, M.; Dunn, D.; Koegler, J.

    2000-01-01

    OBJECTIVE—To examine self service tobacco displays (SSTDs) and youth retail tobacco access by comparing longitudinal illegal tobacco sales rates in three communities in Santa Barbara County, California, that considered or implemented ordinances banning SSTDs. A confirmatory survey was also conducted to substantiate the longitudinal data.
DESIGN—A longitudinal case study design was utilised. Five undercover tobacco buys were conducted between 1994 and 1997 (n = 332). In addition, one confirmatory survey was conducted in a geographically separated area, which had no ordinances banning SSTDs (n = 57).
RESULTS—Decreases in youth buy rates were reported in all three communities. Most notably, the first city to enact a SSTD ban, Carpinteria, achieved a 0% sales rate, which was maintained throughout the study period. In contrast, Santa Barbara and Goleta experienced considerable drops in their illegal sales rates, but neither community obtained results as dramatic as those found in Carpinteria. The confirmatory survey showed that 32.1% of stores with SSTDs sold cigarettes to minors; this compares to a sales rate of 3.4% in stores without SSTDs (χ2 (1) = 8.11, p = 0.004).
CONCLUSIONS—Efforts to enact self service bans are likely to meet with retail and tobacco industry opposition, as was the case in this study's three communities. The process of community debate, resultant publicity surrounding the issue, and enactment of SSTD ordinances may serve to not only increase merchant awareness of youth tobacco laws and their penalties but also may contribute to reduced youth cigarette sales rates. Implications and limitations of the findings are discussed.


Keywords: self service tobacco displays; youth tobacco access; community tobacco control efforts PMID:10691760

  4. Pretreatment of the macroalgae Chaetomorpha linum for the production of bioethanol - Comparison of five pretreatment technologies

    DEFF Research Database (Denmark)

    Schultz-Jensen, Nadja; Thygesen, Anders; Thomsen, Sune Tjalfe

    2013-01-01

    A qualified estimate for pretreatment of the macroalgae Chaetomorpha linum for ethanol production was given, based on the experience of pretreatment of land-based biomass. C. linum was subjected to hydrothermal pretreatment (HTT), wet oxidation (WO), steam explosion (STEX), plasma......-assisted pretreatment (PAP) and ball milling (BM), to determine effects of the pretreatment methods on the conversion of C. linum into ethanol by simultaneous saccharification and fermentation (SSF). WO and BM showed the highest ethanol yield of 44. g ethanol/100. g glucan, which was close to the theoretical ethanol...... yield of 57. g ethanol/100. g glucan. A 64% higher ethanol yield, based on raw material, was reached after pretreatment with WO and BM compared with unpretreated C. linum, however 50% of the biomass was lost during WO. Results indicated that the right combination of pretreatment and marine macroalgae...

  5. Exponential Monte Carlo Convergence of a Three-Dimensional Discrete Ordinates Solution

    Energy Technology Data Exchange (ETDEWEB)

    Favorite, J.A.; Lichtenstein, H.

    1999-11-14

    Recent work on obtaining exponential convergence for three-dimensional solutions to the spatially and angularly continuous monoenergetic transport equation with isotropic scattering using the reduced source method was promising. The method, however, used two separate estimates of the scalar flux, a Legendre expansion (in the spatial variables) and a quadrature of the angular flux. This introduced an inconsistency that may have lead to some convergence problems. To remove this inconsistency and provide a fairer test of the combined reduced source/Monte Carlo method, the method was applied to estimate the coefficients of a Legendre expansion of the solution of the discrete ordinates equations. In this case, no supplementary approximations were required.

  6. Insulation co-ordination in high-voltage electric power systems

    CERN Document Server

    Diesendorf, W

    2015-01-01

    Insulation Co-ordination in High-Voltage Electric Power Systems deals with the methods of insulation needed in different circumstances. The book covers topics such as overvoltages and lightning surges; disruptive discharge and withstand voltages; self-restoring and non-self-restoring insulation; lightning overvoltages on transmission lines; and the attenuation and distortion of lightning surges. Also covered in the book are topics such as the switching surge designs of transmission lines, as well as the insulation coordination of high-voltage stations. The text is recommended for electrical en

  7. A Polar Discrete Ordinate Radiation Transport Method for 2D ALE Meshes in HYDRA

    Science.gov (United States)

    Chang, Britton; Marinak, Marty; Weber, Chris; Peterson, Luc

    2016-10-01

    The Polar Discrete Ordinate Radiation Transport Method in HYDRA has been extended to handle general 2D r-z meshes. Previously the method was only for orthogonal 2D meshes. The new method can be employed with the ALE methodology for managing mesh motion that is used to simulate Rayleigh-Taylor and Richtmyer-Meshkov instabilities on NIF capsule implosions. The results of an examination of this kind will be compared to those obtained by the corresponding diffusion method. This work was performed under the auspices of the Lawrence Livermore National Security, LLC, (LLNS) under Contract No. DE-AC52-07NA27344.

  8. An estimation approach for dividable multiattribute utility of housing via questionnaires of consumers' ordinal multicriteria preferences

    Institute of Scientific and Technical Information of China (English)

    翟凤勇; 王要武

    2004-01-01

    multi-function characteristic. How to evaluate the multi-functional nature of housing is very useful in both theory and in application, yet it is often ignored in China. This paper introduces an approach to estimate the muhicriteria function of housing using multiattribute utility theory (MAUT) based on consumers' ordinal multicriteria peferences as determined via questionnaires. When compared with the classic framework in which MAUT is applied, this approach needs less prior information and subjective comparisons and thus can allay many of the operational difficulties involved in assessment. Some potential applications to the China housing market are also discussed.

  9. Evaluation of Boulder, CO,SmartRegs Ordinance and Better Buildings Program

    Energy Technology Data Exchange (ETDEWEB)

    Arena, L. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States); Vijayakumar, G. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States)

    2012-04-01

    Under the SmartRegs ordinance in the city of Boulder, Colorado, all rental properties in the city must achieve an energy efficiency level comparable to a HERS Index of approximately 120 points or lower by the year 2019. The City of Boulder received a $12 million grant from the DOE’s Better Buildings initiative to create and incentivize their EnergySmart Program. In this report, the Consortium for Advanced Residential Buildings (CARB) describes its work with the program, including energy audits of rental properties, developing training programs for insulators and inspectors, and conducting interviews with property owners.

  10. Evaluation of Boulder, CO, SmartRegs Ordinance and Better Buildings Program

    Energy Technology Data Exchange (ETDEWEB)

    Arena, L.; Vijayakumar, G.

    2012-04-01

    Under the SmartRegs ordinance in the city of Boulder, Colorado, all rental properties in the city must achieve an energy efficiency level comparable to a HERS Index of approximately 120 points or lower by the year 2019. The City of Boulder received a $12 million grant from the DOE's Better Buildings initiative to create and incentivize their EnergySmart Program. In this report, the Consortium for Advanced Residential Buildings (CARB) describes its work with the program, including energy audits of rental properties, developing training programs for insulators and inspectors, and conducting interviews with property owners.

  11. Ordinal preference elicitation methods in health economics and health services research: using discrete choice experiments and ranking methods.

    Science.gov (United States)

    Ali, Shehzad; Ronaldson, Sarah

    2012-09-01

    The predominant method of economic evaluation is cost-utility analysis, which uses cardinal preference elicitation methods, including the standard gamble and time trade-off. However, such approach is not suitable for understanding trade-offs between process attributes, non-health outcomes and health outcomes to evaluate current practices, develop new programmes and predict demand for services and products. Ordinal preference elicitation methods including discrete choice experiments and ranking methods are therefore commonly used in health economics and health service research. Cardinal methods have been criticized on the grounds of cognitive complexity, difficulty of administration, contamination by risk and preference attitudes, and potential violation of underlying assumptions. Ordinal methods have gained popularity because of reduced cognitive burden, lower degree of abstract reasoning, reduced measurement error, ease of administration and ability to use both health and non-health outcomes. The underlying assumptions of ordinal methods may be violated when respondents use cognitive shortcuts, or cannot comprehend the ordinal task or interpret attributes and levels, or use 'irrational' choice behaviour or refuse to trade-off certain attributes. CURRENT USE AND GROWING AREAS: Ordinal methods are commonly used to evaluate preference for attributes of health services, products, practices, interventions, policies and, more recently, to estimate utility weights. AREAS FOR ON-GOING RESEARCH: There is growing research on developing optimal designs, evaluating the rationalization process, using qualitative tools for developing ordinal methods, evaluating consistency with utility theory, appropriate statistical methods for analysis, generalizability of results and comparing ordinal methods against each other and with cardinal measures.

  12. Microscale modelling of ambient air concentrations resulting from the increased combustion of biomass firing systems within the 1{sup st} Ordinance for the Implementation of the Federal Immission Control Act (1. BImSchV); Modellrechnungen zu den Immissionsbelastungen bei einer verstaerkten Verfeuerung von Biomasse in Feuerungsanlagen der 1. BImSchV

    Energy Technology Data Exchange (ETDEWEB)

    Baumbach, Guenter; Struschka, Michael; Juschka, Winfried; Carrasco, Maria; Ang, Keng Been; Hu, Lupin [Stuttgart Univ. (DE). Inst. fuer Verfahrenstechnik und Dampfkesselwesen (IVD); Baechlin, Wolfgang; Soergel, Christine [Ingenieurbuero Lohmeyer GmbH und Co. KG, Karlsruhe (Germany)

    2010-06-15

    By means of a detailed emissions modelling with subsequent highly resolved ambient air pollutant dispersion modelling an assessment method has been developed. This method is a tool for city planners to assess the effects of an increased usage of biomass in heating firings on the air quality situation in different residential areas. Emission simulations have been carried out for the combustion of wood pellets, log wood, wood chips and grain residues as well as for natural gas and heating oil. The emissions depend on the ambient temperature, the building and user specific heat demand and on the operation conditions of the firing. For the operation conditions different emission factors have been set for nominal and partial load as well as for unsteady conditions like boiler start or for shutdown of the firing. The following firings have been considered for burning the above mentioned fuels: Central heating boilers, decentralised heating networks with pellet and wood chip boilers, single stoves for additional heating and grain residue furnaces. Dependent on the ambient temperature for different regions of Germany and for a reference year of the Deutsche Wetterdienst annual emission time series with 1h resolution have been calculated for the different firing fuel combinations. Using these modelled emission data dispersion modelling was carried out for different meteorological and building specific frame conditions. A rural and an urban model area have been investigated. The emissions time series which were calculated for the individual buildings with 1h time resolution were spatially allocated and each single chimney was simulated as point source. For modelling the flow field coined by the building structure the flow model MISKAM has been applied. For dispersion simulation the model AUSTAL2000 has been used. Simulations have been carried out with three different wind and dispersion class distributions typical for many regions of Germany. A further parameter variation

  13. Biorefining of wheat straw: accounting for the distribution of mineral elements in pretreated biomass by an extended pretreatment – severity equation

    DEFF Research Database (Denmark)

    Le, Duy Michael; Sørensen, Hanne Risbjerg; Knudsen, Niels Ole;

    2014-01-01

    Background: Mineral elements present in lignocellulosic biomass feedstocks may accumulate in biorefinery process streams and cause technological problems, or alternatively can be reaped for value addition. A better understanding of the distribution of minerals in biomass in response to pretreatment...... factors is therefore important in relation to development of new biorefinery processes. The objective of the present study was to examine the levels of mineral elements in pretreated wheat straw in response to systematic variations in the hydrothermal pretreatment parameters (pH, temperature......, and treatment time), and to assess whether it is possible to model mineral levels in the pretreated fiber fraction. Results: Principal component analysis of the wheat straw biomass constituents, including mineral elements, showed that the recovered levels of wheat straw constituents after different hydrothermal...

  14. Pretreatment of sugar cane bagasse for enhanced ruminal digestion.

    Science.gov (United States)

    Deschamps, F C; Ramos, L P; Fontana, J D

    1996-01-01

    Crop residues, such as sugar cane bagasse (SCB), have been largely used for cattle feeding. However, the close association that exists among the three major plant cell-wall components, cellulose, hemicellulose, and lignin, limits the efficiency by which ruminants can degrade these materials. Previously, we have shown that pretreatment with 3% (w/w) phosphoric acid, under relatively mild conditions, increased considerably the nutritional value for SCB. However, in this preliminary study, pretreated residues were not washed prior to in situ degradability assays because we wanted to explore the high initial solvability of lowmol-wt substances that were produced during pretreatment. We have now studied the suitability of water-and/or alkali-washed residues to in situ ruminal digestion. Alkali washing increased substrate cellulose content by removing most of the lignin and other residual soluble substances. As a result the ruminal degradability of these cleaner materials had first-order rate constants five times higher than those substrates with higher lignin content (e.g., stem-exploded bagasse). However, alkali washing also increased the time of ruminal lag phase of the cellulosic residue, probably because of hemicellulose and/or lignin removal and to the development of substrates with higher degree of crystallinity. Therefore, longer lag phases appear to be related to low microbial adherence after extensive water and alkali extraction, as Novell as to the slower process of cellulase induction during ruminal growth. The kinetic data on ruminal digestion were shown to be very well adjusted by a nonlinear model. Although pretreatment enhances substrate accessibility, the occurrence of an exceedingly high amount of lignin byproducts within the pretreated material reduces considerably its potential degradability.

  15. Human olfactory mesenchymal stromal cell transplants promote remyelination and earlier improvement in gait co‐ordination after spinal cord injury

    Science.gov (United States)

    Lindsay, Susan L.; Toft, Andrew; Griffin, Jacob; M. M. Emraja, Ahmed

    2017-01-01

    Autologous cell transplantation is a promising strategy for repair of the injured spinal cord. Here we have studied the repair potential of mesenchymal stromal cells isolated from the human olfactory mucosa after transplantation into a rodent model of incomplete spinal cord injury. Investigation of peripheral type remyelination at the injury site using immunocytochemistry for P0, showed a more extensive distribution in transplanted compared with control animals. In addition to the typical distribution in the dorsal columns (common to all animals), in transplanted animals only, P0 immunolabelling was consistently detected in white matter lateral and ventral to the injury site. Transplanted animals also showed reduced cavitation. Several functional outcome measures including end‐point electrophysiological testing of dorsal column conduction and weekly behavioural testing of BBB, weight bearing and pain, showed no difference between transplanted and control animals. However, gait analysis revealed an earlier recovery of co‐ordination between forelimb and hindlimb stepping in transplanted animals. This improvement in gait may be associated with the enhanced myelination in ventral and lateral white matter, where fibre tracts important for locomotion reside. Autologous transplantation of mesenchymal stromal cells from the olfactory mucosa may therefore be therapeutically beneficial in the treatment of spinal cord injury. GLIA 2017 GLIA 2017;65:639–656 PMID:28144983

  16. Steroids pretreatment in assisted reproduction cycles.

    Science.gov (United States)

    Sobotka, V; Streda, R; Mardesic, T; Tosner, J; Heracek, J

    2014-01-01

    The objective is to present an overview of trials and appreciate the relevant data on the effect of steroids pretreatment (oral contraceptives, 17β-estradiol and estradiol valerate) in assisted reproduction cycles. The subject of the study is to evaluate the clinical characteristics during steroids pretreatment cycles focused on the prevention of ovarian cysts, the positive contraceptive effect on the onset of regular period during long gonadotropin releasing hormone agonist protocol. In gonadotropin releasing hormone antagonist protocol the review is interested in supporting ovarian stimulation in low responders, the idea of cycle scheduling and improving treatment outcomes. The method is a review from MEDLINE/Pubmed database between 1994 and July 2012. We identified 15 randomised controlled trials (n=3069 patients). One trail (n=83 patients) assessed GnRH agonist protocol with or without steroids pretreatment, 8 trials (n=1884 patients) assessed GnRH antagonist protocols with or without steroids pretreatment and 6 trials (n=1102 patients) assessed GnRH antagonist protocols versus agonist ones with steroid pretreatment. Data demonstrates that oral contraceptives offer the effective prevention of functional ovarian cysts, the predictable onset of period during desensitisation. Existing data suggest that pretreatment with oral contraceptive pills or estradiol valerate give no advantage concerning number of oocytes or pregnancy rate. Pretreatment with oral contraceptive pills aiming to avoid weekend oocytes retrievals has to be more elucidated. In low responders oral contraceptive pill pretreatment may be beneficial in improving ovarian responses by reducing the amount of gonadotropins and the number of days required for ovarian stimulation. Current research indicates that also 17β-estradiol may be encouraging pretreatment in low responders and in cycle scheduling. This article is part of a Special Issue entitled 'Pregnancy and Steroids'.

  17. Enhancement of drying and rehydration characteristics of okra by ultrasound pre-treatment application

    Science.gov (United States)

    Tüfekçi, Senem; Özkal, Sami Gökhan

    2017-02-01

    Effect of ultrasound application prior to hot air drying on drying and rehydration kinetics, rehydration ratio and microstructure of okra slices were investigated. For this purpose, the selected parameters are ultrasound pre-treatment time (10, 20 and 30 min), ultrasound amplitude (55 and 100%) and the temperature of drying air (60 and 70 °C). 5 mm thick cylindrical shaped okra slices were used in the experiments. The samples were immersed in water and ultrasonic pre-treatments were done in water with ultrasonic probe connected to an ultrasonic generator with 20 kHz frequency. Pre-treated samples were dried in a tray drier with a 0.3 m/s air velocity. Ultrasound pre-treatment affected the drying rate of the okra slices significantly. Drying time of okra slices was decreased by the application of ultrasound pre-treatment. Modified Page model found to be the most suitable model for describing the drying characteristics of okra slices. Improvements in rehydration properties of the dried samples were observed due to the ultrasound pre-treatment. The influence of the ultrasound pre-treatment on microstructure was clearly observed through scanning electron microscopy images of the dried samples. As the amplitude of ultrasound increased the changes in structure of the okra tissue increased.

  18. Integrated analysis of hydrothermal flow through pretreatment

    Directory of Open Access Journals (Sweden)

    Archambault-Leger Veronique

    2012-07-01

    Full Text Available Abstract Background The impact of hydrothermal flowthrough (FT pretreatment severity on pretreatment and solubilization performance metrics was evaluated for three milled feedstocks (corn stover, bagasse, and poplar and two conversion systems (simultaneous saccharification and fermentation using yeast and fungal cellulase, and fermentation by Clostridium thermocellum. Results Compared to batch pretreatment, FT pretreatment consistently resulted in higher XMG recovery, higher removal of non-carbohydrate carbon and higher glucan solubilization by simultaneous saccharification and fermentation (SSF. XMG recovery was above 90% for FT pretreatment below 4.1 severity but decreased at higher severities, particularly for bagasse. Removal of non-carbohydrate carbon during FT pretreatment increased from 65% at low severity to 80% at high severity for corn stover, and from 40% to 70% for bagasse and poplar. Solids obtained by FT pretreatment were amenable to high conversion for all of the feedstocks and conversion systems examined. The optimal time and temperature for FT pretreatment on poplar were found to be 16 min and 210°C. At these conditions, SSF glucan conversion was about 85%, 94% of the XMG was removed, and 62% of the non carbohydrate mass was solubilized. Solubilization of FT-pretreated poplar was compared for C. thermocellum fermentation (10% inoculum, and for yeast-fungal cellulase SSF (5% inoculum, cellulase loading of 5 and 10 FPU/g glucan supplemented with β-glucosidase at 15 and 30 U/g glucan. Under the conditions tested, which featured low solids concentration, C. thermocellum fermentation achieved faster rates and more complete conversion of FT-pretreated poplar than did SSF. Compared to SSF, solubilization by C. thermocellum was 30% higher after 4 days, and was over twice as fast on ball-milled FT-pretreated poplar. Conclusions XMG removal trends were similar between feedstocks whereas glucan conversion trends were significantly

  19. GPU accelerated simulations of 3D deterministic particle transport using discrete ordinates method

    Science.gov (United States)

    Gong, Chunye; Liu, Jie; Chi, Lihua; Huang, Haowei; Fang, Jingyue; Gong, Zhenghu

    2011-07-01

    Graphics Processing Unit (GPU), originally developed for real-time, high-definition 3D graphics in computer games, now provides great faculty in solving scientific applications. The basis of particle transport simulation is the time-dependent, multi-group, inhomogeneous Boltzmann transport equation. The numerical solution to the Boltzmann equation involves the discrete ordinates ( Sn) method and the procedure of source iteration. In this paper, we present a GPU accelerated simulation of one energy group time-independent deterministic discrete ordinates particle transport in 3D Cartesian geometry (Sweep3D). The performance of the GPU simulations are reported with the simulations of vacuum boundary condition. The discussion of the relative advantages and disadvantages of the GPU implementation, the simulation on multi GPUs, the programming effort and code portability are also reported. The results show that the overall performance speedup of one NVIDIA Tesla M2050 GPU ranges from 2.56 compared with one Intel Xeon X5670 chip to 8.14 compared with one Intel Core Q6600 chip for no flux fixup. The simulation with flux fixup on one M2050 is 1.23 times faster than on one X5670.

  20. An experimental test of CSR theory using a globally calibrated ordination method.

    Science.gov (United States)

    Li, Yuanzhi; Shipley, Bill

    2017-01-01

    Can CSR theory, in conjunction with a recently proposed globally calibrated CSR ordination ("StrateFy"), using only three easily measured leaf traits (leaf area, specific leaf area and leaf dry matter content) predict the functional signature of herbaceous vegetation along experimentally manipulated gradients of soil fertility and disturbance? To determine this, we grew 37 herbaceous species in mixture for five years in 24 experimental mesocosms differing in factorial levels of soil resources (stress) and density-independent mortality (disturbance). We measured 16 different functional traits and then ordinated the resulting vegetation within the CSR triangle using StrateFy. We then calculated community-weighted mean (CWM) values of the competitor (CCWM), stress-tolerator (SCWM) and ruderal (RCWM) scores for each mesocosm. We found a significant increase in SCWM from low to high stress mesocosms, and an increase in RCWM from lowly to highly disturbed mesocosms. However, CCWM did not decline significantly as intensity of stress or disturbance increased, as predicted by CSR theory. This last result likely arose because our herbaceous species were relatively poor competitors in global comparisons and thus no strong competitors in our species pool were selectively favoured in low stress and low disturbed mesocosms. Variation in the 13 other traits, not used by StrateFy, largely argeed with the predictions of CSR theory. StrateFy worked surprisingly well in our experimental study except for the C-dimension. Despite loss of some precision, it has great potential applicability in future studies due to its simplicity and generality.

  1. A voice from the margins: Investigating the African Adventist rationale on the quest for female ordination

    Directory of Open Access Journals (Sweden)

    Rebecca J. Lagat

    2016-03-01

    Full Text Available Discussions surrounding women�s ordination reached a peak with the 60th General Conference Session (GCS 2015 of the Seventh-day Adventist (SDA Church. A report compiled by a section of delegates from the East-Central Africa Division � Biblical Research Committee indicated that this continent was not yet ready to ordain women as pastors. In light of the report, this article aims to investigate the rationale of such a stark decision. Firstly, the report shows that African Adventist women theologians were omitted from the discussions � a lack of good will from the church leadership towards the females as the majority of the membership. Secondly, the decision against ordination of women is suspect and biblically inconclusive. Through an overview of literature on a biblical missional design, the article postulates: Contextualisation and theologising are necessary for Africa, but the SDA Church must remember that globally both theology and culture are subject to the biblical guidelines, and thus to God�s missio Dei as well.Intradisciplinary and/or interdisciplinary implications: This article balances cultural contextualism and gender relations � challenging a cultural bias through a missional hermeneutic. This can lead to fairer representation of African women in Adventist church structures and reroute the equality discourse in light of the missio Dei. The study intersects with cultural theory, social analysis and biblical hermeneutics.�

  2. Night and days in Cassiciacum: The anti-Manichaean theodicy of Augustine’s De ordine

    Directory of Open Access Journals (Sweden)

    Therese Fuhrer

    2013-04-01

    Full Text Available In his early dialogue ‘On order’ (De ordine Augustine dramatises a discussion of theodicy in which the Manichaean solution is clearly rejected, even though the debate ends in aporia. It is argued in this paper that the dialogue’s dramatic setting at the villa in Cassiciacum is strongly reminiscent of Manichaean imagery and the stock motifs of the Manichaean mythological system. It is proposed in the dialogue itself, that the scenic elements (Augustine’s ill health, night and darkness, the dawning day, dirt and ugliness, fighting cocks have the character of signs which illustrate the significance of the not-beautiful and the negative in the divine order. The dialogue setting thus presents an ontological scale that leads from the levels of reduced being up to the highest being, linking night or darkness to light or day, dirt to purity, sickness to health, defeat to victory, the ugly to the beautiful. The dialogue setting becomes a semiotic system in which even the ontologically deficient forms of phenomenon always also refer to something at the highest level, namely the omnipotent divine creator. The scenic design of De ordine can thus be read as an extension of the Manichaean system of codes, and hence as a message also addressed to a Manichaean readership.

  3. Explosive ordinance disposal technology demonstration using the telerobotic small emplacement excavator

    Energy Technology Data Exchange (ETDEWEB)

    Burks, B.L.; Killough, S.M.; Thompson, D.H.; Dinkins, M.A. [Oak Ridge National Lab., TN (United States). Robotics & Process Systems Div.

    1994-06-01

    The small emplacement excavator (SEE) is a ruggedized military vehicle with backhoe and front loader used by the US Army for explosive ordinance disposal (EOD), combat engineer, and general utility excavation activities. In order to evaluate the feasibility of removing personnel from the vehicle during the high risk EOD excavation tasks a development and demonstration project was initiated to evaluate performance capabilities of the SEE under telerobotic control. This feasibility study was performed at the request of the Ordinance Missile and Munitions Center and School (OMMCS) at the Redstone Arsenal to help define requirements for further joint service development activities. Development of a telerobotic SEE (TSEE) was performed by the Oak Ridge National Laboratory (ORNL) in a project funded jointly by the US Army Project Manager for Ammunition Logistics (PM-AMMOLOG) and the Department of Energy (DOE) Office of Technology Development (OTD) Robotics Technology Development Program (RTDP). A technology demonstration of the TSEE was conducted at McKinley Range, Redstone Arsenal, Huntsville, Alabama, on September 13--17, 1993. The primary objective of the demonstration was to evaluate and demonstrate the feasibility of remote EOD. During the demonstration, approximately 40 EOD specialists were instructed on telerobotic operation of the TSEE and then were asked to complete a series of simulated EOD tasks. Upon completion of the tasks, participants completed an evaluation of the system including human factors performance data.

  4. Hypothesis testing and estimation in ordinal data under a simple crossover design.

    Science.gov (United States)

    Lui, Kung-Jong; Chang, Kuang-Chao

    2012-01-01

    Since each patient serves as his/her own control, the crossover design can be of use to improve power as compared with the parallel-groups design in studying noncurative treatments to certain chronic diseases. Although the research studies on the crossover design have been quite intensive, the discussions on analyzing ordinal data under such a design are truly limited. We propose using the generalized odds ratio (GOR) for paired sample data to measure the relative effect on patient responses for both treatment and period in ordinal data under a simple crossover trial. Assuming the treatment and period effects are multiplicative, we note that one can easily derive the maximum likelihood estimator (LE) in closed forms for the GOR of treatment and period effects. We develop asymptotic and exact procedures for testing treatment and period effects. We further derive asymptotic and exact interval estimators for the GOR of treatment and period effects. We use the data taken from a crossover trial to assess the clarity of leaflet instructions between two devices among asthma patients to illustrate the use of these test procedures and estimators developed here.

  5. Natural join construction of graded posets versus ordinal sum and discrete hyper boxes

    CERN Document Server

    Kwasniewski, A K

    2009-01-01

    One introduces here the natural join $P \\os Q$ of graded posets $$ and $$ with correspondingly maximal and minimal sets being identical as expressed by ordinal sum $P\\oplus Q$ apart from other definition and due to that one arrives at a simple proof of the $M{\\"{o}}bius $ function formula for cobweb posets. We also quote the other authors explicit formulas for the zeta matrix and its inverse for any graded posets with the finite set of minimal elements from earlier works of the author. These formulas are based on the formulas for cobweb posets and their $Hasse$ diagrams or graphs named $KoDAGs$ which are interpreted as chains of binary complete or universal relations joined by the natural join operation. Natural join of two independent sets is therefore the ordinal sum of this trivially ordered posets represented also by directed biclique named dibiclique and correspondingly by their $Hasse $ diagrams or graphs named $KoDAGs$. Such cobweb posets and equivalently their Hasse diagrams or graphs named $KoDAGs$ a...

  6. Industrial Pretreatment Program for New England

    Science.gov (United States)

    The Industrial Pretreatment Program prevents the discharge of pollutants to Publicly-Owned Treatment Works (POTWs) which will interfere with the operations of the POTW or its use and disposal of municipal biosolids.

  7. Understanding Ionic Liquid Pretreatment of Lignocellulosic Biomasses

    Science.gov (United States)

    Pretreatment of biomass is essential for breaking apart highly ordered and crystalline plant cell walls and loosening the lignin and hemicellulose conjugation to cellulose microfibrills, thereby facilitating enzyme accessibility and adsorption and reducing costs of downstream saccharification proces...

  8. Extrusion Pretreatment of Lignocellulosic Biomass: A Review

    Directory of Open Access Journals (Sweden)

    Jun Zheng

    2014-10-01

    Full Text Available Bioconversion of lignocellulosic biomass to bioethanol has shown environmental, economic and energetic advantages in comparison to bioethanol produced from sugar or starch. However, the pretreatment process for increasing the enzymatic accessibility and improving the digestibility of cellulose is hindered by many physical-chemical, structural and compositional factors, which make these materials difficult to be used as feedstocks for ethanol production. A wide range of pretreatment methods has been developed to alter or remove structural and compositional impediments to (enzymatic hydrolysis over the last few decades; however, only a few of them can be used at commercial scale due to economic feasibility. This paper will give an overview of extrusion pretreatment for bioethanol production with a special focus on twin-screw extruders. An economic assessment of this pretreatment is also discussed to determine its feasibility for future industrial cellulosic ethanol plant designs.

  9. 应用结构异质性阈值模型定位阈值性状基因位点:Ⅱ仿真研究%Mapping Quantitative Trait Loci of Ordinal Traits Using a Structural HeteroskedasticThreshold Model: Ⅱ Numerical Application

    Institute of Scientific and Technical Information of China (English)

    饶绍奇; 张庆普; 李霞; 郭政

    2001-01-01

    蒙特卡罗仿真研究表明:对处理在基因定位阈值性状中出现的超离中趋势现象(结构异质性),我们提出的结构异质性模型是一个高效的统计方法.它表现在高效率的统计检验、准确的参数估计和基因定位等方面.病态或奇异费歇信息矩阵是在基因连锁定位分析中的一个突出的算法问题,仿真数据显示它们的发生率可以达到28%.我们提出的应用奇异根分解方法可以有效地解决这一算法问题.对比常规阈值模型,结构异质性阈值模型有较高的算法稳定性.%Monte Carlo simulation studies indicate that the newly developed structuralheteroskedastic threshold model, with an aim at handling overdispersion problem in QTL mapping ofordinal traits, is an efficient statistical method in terms of power and genetic parameter estimationunder various designs. The incidence of ill-condition or singularity of the Fisher information matrix ina genome scan of linkage is high (up to 28%), suggesting that a more robust numerical algorithm(e. g. , singular value decomposition used in this study) is required to handle numerical problems inthe implement of a generalized linear model in genetic mapping.

  10. A survey of the information on co-ordination compound features which can be gained from electroanalytical methods.

    Science.gov (United States)

    Bontempelli, G; Andreuzzi-Sedea, M; Fiorani, M

    1982-12-01

    The information provided by modern electroanalytical techniques on co-ordination compounds is surveyed. The problem of the interaction between the electrode and intermediates or products is also briefly considered; it is pointed out that the electroanalytical approach can be successfully employed to provide new insight into chemical properties of metal complexes only when weakly interacting species are involved. The information obtainable is considered under the following headings: (i) mechanistic studies on metal complexes and electroanalytical evidence for their reactivity and stability; (ii) structural features of co-ordination compounds in solution; (iii) feasibility of electrochemical syntheses; and (iv) stability of intermediate oxidation states with reference to the nature of the ligands co-ordinated to the metal.

  11. Distinct representations of symbolic ordinality and quantity: evidence from neuropsychological investigations in a Chinese patient with Gerstmann's syndrome.

    Science.gov (United States)

    Chen, Zhongqin; Xu, Mingwei; Shang, Desheng; Peng, Guoping; Luo, Benyan

    2014-07-01

    A number of recent studies have shown conflicting evidence as to common or distinct representations between symbolic ordinality and quantity. We investigated this issue through a series of neuropsychological tests in a unique Chinese patient with the left angular gyrus and left supramarginal gyrus lesions. Behavioral experiments revealed that (1) the patient showed Gerstmann syndrome, with minimal anomia and alexia and (2) the patient showed the dissociation among number semantic representations with relatively preserved symbolic quantity knowledge and impaired processing of symbolic order meaning. Together with existing evidence in the literature, results of the current study suggest that there might be two separate cognitive representations of symbolic ordinality and quantity in logographic language according to this dissociation. Most importantly, another merit of this study is that the left angular gyrus and left supramarginal gyrus might be necessary to symbolic ordinality representation.

  12. Pretreatment techniques for biofuels and biorefineries

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Zhen (ed.) [Chinese Academy of Sciences, Kunming, YN (China). Xishuangbanna Tropical Botonical Garden

    2013-02-01

    The first book focused on pretreatment techniques for biofuels contributed by the world's leading experts. Extensively covers the different types of biomass, various pretreatment approaches and methods that show the subsequent production of biofuels and chemicals. In addition to traditional pretreatment methods, novel techniques are also introduced and discussed. An accessible reference work for students, researchers, academicians and industrialists in biorefineries. This book includes 19 chapters contributed by the world's leading experts on pretreatment methods for biomass. It extensively covers the different types of biomass (e.g. molasses, sugar beet pulp, cheese whey, sugarcane residues, palm waste, vegetable oil, straws, stalks and wood), various pretreatment approaches (e.g. physical, thermal, chemical, physicochemical and biological) and methods that show the subsequent production of biofuels and chemicals such as sugars, ethanol, extracellular polysaccharides, biodiesel, gas and oil. In addition to traditional methods such as steam, hot-water, hydrothermal, diluted-acid, organosolv, ozonolysis, sulfite, milling, fungal and bacterial, microwave, ultrasonic, plasma, torrefaction, pelletization, gasification (including biogas) and liquefaction pretreatments, it also introduces and discusses novel techniques such as nano and solid catalysts, organic electrolyte solutions and ionic liquids. This book offers a review of state-of-the-art research and provides guidance for the future paths of developing pretreatment techniques of biomass for biofuels, especially in the fields of biotechnology, microbiology, chemistry, materials science and engineering. It intends to provide a systematic introduction of pretreatment techniques. It is an accessible reference work for students, researchers, academicians and industrialists in biorefineries.

  13. Beta-mapping and beta-regression for changes of ordinal-rating measurements on Likert scales: a comparison of the change scores among multiple treatment groups.

    Science.gov (United States)

    Zou, Kelly H; Carlsson, Martin O; Quinn, Sheila A

    2010-10-30

    Patient reported outcome and observer evaluative studies in clinical trials and post-hoc analyses often use instruments that measure responses on ordinal-rating or Likert scales. We propose a flexible distributional approach by modeling the change scores from the baseline to the end of the study using independent beta distributions. The two shape parameters of the fitted beta distributions are estimated by matching-moments. Covariates and the interaction terms are included in multivariate beta-regression analyses under generalized linear mixed models. These methods are illustrated on the treatment satisfaction data in an overactive bladder drug study with four treatment arms. Monte-Carlo simulations were conducted to compare the Type 1 errors and statistical powers using a beta likelihood ratio test of the proposed method against its fully nonparametric or parametric alternatives. Copyright © 2010 John Wiley & Sons, Ltd.

  14. Effect of pretreatment on the enzymatic hydrolysis of kitchen waste for xanthan production.

    Science.gov (United States)

    Li, Panyu; Zeng, Yu; Xie, Yi; Li, Xiang; Kang, Yan; Wang, Yabo; Xie, Tonghui; Zhang, Yongkui

    2017-01-01

    The study was carried out to gain insight into the effect of pretreatment on enzymatic hydrolysis of kitchen waste (KW) for xanthan fermentation. Herein, various pretreatments were applied and it was found that chemical pretreatment had positive effect on the following enzymatic or overall hydrolysis process. The highest reducing sugar concentration was obtained as 51.87g/L from 2% HCl (90°C) pretreated sample, while the Kjeldahl nitrogen (KDN) concentration was 7.79g/L. Kinetic study showed that first order kinetic model was suitable to describe the enzymatic hydrolysis process. The obtained kitchen waste hydrolysate (KWH) was successfully applied for xanthan fermentation. Xanthan concentration reached 4.09-6.46g/L when KWH with 2% HCl (90°C) pretreatment was applied as medium. In comparison, a xanthan concentration of 3.25-5.57g/L was obtained from KWH without pretreatment. Therefore, pretreatment of KW using diluted acid is favorable for the overall hydrolysis process and effective for xanthan fermentation.

  15. Comparative AMS radiocarbon dating of pretreated versus non-pretreated tropical wood samples

    Energy Technology Data Exchange (ETDEWEB)

    Patrut, Adrian [Department of Chemistry, Babes-Bolyai University, 400028 Cluj-Napoca (Romania); Reden, Karl F. von, E-mail: kvonreden@whoi.ed [NOSAMS Facility, Department of Geology and Geophysics, Woods Hole Oceanographic Institution, Woods Hole, MA 02543 (United States); Lowy, Daniel A. [Nova Research Inc., Alexandria, VA 22308 (United States); Mayne, Diana H. [Baobab Trust, P.O. Box 1566, Parklands 2121, Johannesburg (South Africa); Elder, Kathryn E.; Roberts, Mark L.; McNichol, Ann P. [NOSAMS Facility, Department of Geology and Geophysics, Woods Hole Oceanographic Institution, Woods Hole, MA 02543 (United States)

    2010-04-15

    Several wood samples collected from Dorslandboom, a large iconic African baobab (Adansonia digitata L.) from Namibia, were investigated by AMS radiocarbon dating subsequent to pretreatment and, alternatively, without pretreatment. The comparative statistical evaluation of results showed that there were no significant differences between fraction modern values and radiocarbon dates of the samples analyzed after pretreatment and without pretreatment, respectively. The radiocarbon date of the oldest sample was 993 +- 20 BP. Dating results also revealed that Dorslandboom is a multi-generation tree, with several stems showing different ages.

  16. Comparative AMS radiocarbon dating of pretreated versus non-pretreated tropical wood samples

    Science.gov (United States)

    Patrut, Adrian; von Reden, Karl F.; Lowy, Daniel A.; Mayne, Diana H.; Elder, Kathryn E.; Roberts, Mark L.; McNichol, Ann P.

    2010-04-01

    Several wood samples collected from Dorslandboom, a large iconic African baobab ( Adansonia digitata L.) from Namibia, were investigated by AMS radiocarbon dating subsequent to pretreatment and, alternatively, without pretreatment. The comparative statistical evaluation of results showed that there were no significant differences between fraction modern values and radiocarbon dates of the samples analyzed after pretreatment and without pretreatment, respectively. The radiocarbon date of the oldest sample was 993 ± 20 BP. Dating results also revealed that Dorslandboom is a multi-generation tree, with several stems showing different ages.

  17. Computation of 2-D pinhole image-formation process of large-scale furnaces using the discrete ordinates method

    CERN Document Server

    Li Hong; Lu Ji Dong; Zheng Chu Guan

    2003-01-01

    In most of the discrete ordinate schemes (DOS) reported in the literature, the discrete directions are fixed, and unable to be arbitrarily adjusted; therefore, it is difficult to employ these schemes to calculate the radiative energy image-formation of pulverized-coal furnaces. On the basis of a new DOS, named the discrete ordinate scheme with (an) infinitely small weight(s), which was recently proposed by the authors, a novel algorithm for computing the pinhole image-formation process is developed in this work. The performance of this algorithm is tested, and is found to be also suitable for parallel computation.

  18. Mechanical pre-treatment for enzymatically enhanced energy efficient TMP; Mekanisk foerbehandling av flis foer effektiv enzymatisk paaverkan vid energieffektiv TMP tillverkning

    Energy Technology Data Exchange (ETDEWEB)

    Viforr, Silvia

    2008-11-15

    Thermomechanical pulp (TMP) processes are high energy demanding. This together with the high energy prices of nowadays results in significant costs, why less energy demanding processes are wished. This project has evaluated the potential for energy reductions in a TMP process by a mechanical pre-treatment of the wood chips combined with an enzymatic modification based on a cellulase mixture. The structure of the wood was opened up by the mechanical pre-treatment making it easier for the enzymes to penetrate into the pre-treated wood material. The enzymatic treatment was then run at optimum standard conditions. The EU project - Ecotarget 2004-2008 (www.ecotarget.com) have studied different types of enzymes that could be used for pre-treatment of wood chips in order to save energy during TMP processes. Based on these studies cellulose enzyme was recommended to be used at pre-treatment experiment performed by the Vaermeforsk project. Due to the fact that the Ecotarget-project has also been run during 2008 with activities involving enzymes, the steering board of the Vaermeforsk project took the decision to co-ordinate the experiments from both of the projects. This co-operation increased the funds and also the number of experiments for both of the projects. The experimental results from this project showed that energy reductions at a given tensile index could be achieved if gently mechanical pre-treated wood chips were enzymatically treated. An intensive mechanical pre-treatment gave negative effects on both fibre length and tear index while the light scattering coefficient was promoted, probably due to the fibre shortening. Enzymatic modification of mechanically pre-treated chips showed a favourable modification of the fibres, even regarding the fibre shortening, if compared to mechanical pre-treated chips only. The effects of cellulases was however not as expected, why a high amount of cellulases was used. Other types of enzymes which could attack the primary wall of

  19. Enzymatic Pre-Treatment Increases the Protein Bioaccessibility and Extractability in Dulse (Palmaria palmata

    Directory of Open Access Journals (Sweden)

    Hanne K. Mæhre

    2016-10-01

    Full Text Available Several common protein extraction protocols have been applied on seaweeds, but extraction yields have been limited. The aims of this study were to further develop and optimize existing extraction protocols and to examine the effect of enzymatic pre-treatment on bioaccessibility and extractability of seaweed proteins. Enzymatic pre-treatment of seaweed samples resulted in a three-fold increase in amino acids available for extraction. Combining enzymatic pre-treatment with alkaline extraction resulted in a 1.6-fold increase in the protein extraction yield compared to a standard alkaline extraction protocol. A simulated in vitro gastrointestinal digestion model showed that enzymatic pre-treatment of seaweed increased the amount of amino acids available for intestinal absorption 3.2-fold. In conclusion, enzymatic pre-treatment of seaweeds is effective for increasing the amount of amino acids available for utilization and may thus be an effective means for increasing the utilization potential of seaweed proteins. However, both the enzymatic pre-treatment protocol and the protein extraction protocol need further optimization in order to obtain optimal cost-benefit and results from the in vitro gastrointestinal digestion model need to be confirmed in clinical models.

  20. High-order solution methods for grey discrete ordinates thermal radiative transfer

    Science.gov (United States)

    Maginot, Peter G.; Ragusa, Jean C.; Morel, Jim E.

    2016-12-01

    This work presents a solution methodology for solving the grey radiative transfer equations that is both spatially and temporally more accurate than the canonical radiative transfer solution technique of linear discontinuous finite element discretization in space with implicit Euler integration in time. We solve the grey radiative transfer equations by fully converging the nonlinear temperature dependence of the material specific heat, material opacities, and Planck function. The grey radiative transfer equations are discretized in space using arbitrary-order self-lumping discontinuous finite elements and integrated in time with arbitrary-order diagonally implicit Runge-Kutta time integration techniques. Iterative convergence of the radiation equation is accelerated using a modified interior penalty diffusion operator to precondition the full discrete ordinates transport operator.

  1. Evaluating the implementation of the energy consumption labelling ordinance. Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    Schlomann, B.; Eichhammer, W.; Gruber, E.; Kling, N.; Mannsbart, W.; Stoeckle, F.

    2001-03-01

    The main objective of the study was to examine the present degree of compliance with the Energy Consumption Labelling Ordinance for large household appliances in Germany in an empirical inventory. Concrete proposals to improve the degree of compliance with Directive among manufacturers and retailers were to be elaborated based on this inventory and the analysis of possible deficiencies in implementation and and their causes. A further objective of the study was to examine whether there was an increase in the share of appliance sales in the highest efficiency classes, so as to be able to judge the success of the measures provided in the Directive in accordance with the underlying energy and environmental objective of further reducing energy consumption in households. Furthermore, experience of other European countries in implementing the EU Directive was to be considered. (orig./CB)

  2. Posição ordinal dos filhos, sexo e esquizofrenia

    Directory of Open Access Journals (Sweden)

    Antonios I. Térzis

    1986-06-01

    Full Text Available O presente estudo investigou a hipótese de associação entre a posição ordinal dos filhos dentro de sua prole e a prevalência da esquizofrenia. Para examinar o objetivo acima proposto, foram observados 404 pacientes esquizofrênicos (201 do sexo masculino e 203 do sexo feminino que estavam internados em 5 hospitais da área metropolitana de São Paulo. O método estatístico utilizado, que permitiu a análise dos efeitos da ordem de nascimento sobre a prevalência de esquizofrenia, foi o de Greenwood-Yule. Verificou-se que existe associação entre ordem de nascimento e esquizofrenia e que esta relação pode ser descrita em termos de um excesso de primogênitos esquizofrênicos, tanto masculinos como femininos.

  3. Analysis of ontogenetic spectra of populations of plants and lichens via ordinal regression

    Science.gov (United States)

    Sofronov, G. Yu.; Glotov, N. V.; Ivanov, S. M.

    2015-03-01

    Ontogenetic spectra of plants and lichens tend to vary across the populations. This means that if several subsamples within a sample (or a population) were collected, then the subsamples would not be homogeneous. Consequently, the statistical analysis of the aggregated data would not be correct, which could potentially lead to false biological conclusions. In order to take into account the heterogeneity of the subsamples, we propose to use ordinal regression, which is a type of generalized linear regression. In this paper, we study the populations of cowberry Vaccinium vitis-idaea L. and epiphytic lichens Hypogymnia physodes (L.) Nyl. and Pseudevernia furfuracea (L.) Zopf. We obtain estimates for the proportions of between-sample variability in the total variability of the ontogenetic spectra of the populations.

  4. Note sull'ordine degli elementi in coppie di verbi antonimi

    Directory of Open Access Journals (Sweden)

    Federico Vicario

    2003-12-01

    Full Text Available La riflessione sulle categorie e le proprieta legate al fenomeno dell'antonimia ri­ guarda, in semantica, una serie di fatti senza dubbio interessanti e di notevole com­ plessita. La definizione comune, tradizionale, di antonimia - in una certa misura anche generica - designa, in buona sostanza, l'antitesi tra elementi della lingua, tra parole, che hanno un "significato contrario"1. A partire da tale definizione, che ri­ chiama per altro il principio binario di opposizione che costituisce uno dei fonda­ menti strutturali delle lingue, vd. Lyons (1980: 294 sgg., numerosi sono i modelli di analisi, le tassonomie e le tipologie elaborate per una migliore descrizione del feno­meno  o di casi particolari  del medesimo 2 . Si proporranno  qui, in particolare, alcune brevi osservazioni sull'ordine in cui si presentano i termini che formano  coppie di verbi  antonimi (reciproci.

  5. Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature.

    Science.gov (United States)

    Zhao, Liqing; Wang, Ke; Ferrara, Napoleone; Vu, Thiennu H

    2005-07-01

    The vasculature forms an intrinsic functional component of the lung and its development must be tightly regulated and coordinated with lung epithelial morphogenesis. Vascular endothelial growth factor (VEGF) and its receptors are highly expressed in a complementary pattern in the lungs during embryonic development. VEGF is expressed by epithelium and the receptors in the surrounding mesenchyme. To determine the function of VEGF in lung formation, we inhibited its activity using a soluble receptor in lung renal capsule grafts. Inhibition of VEGF results in inhibition of vascular development and significant alteration in epithelial development. Epithelial proliferation is inhibited, sacculation is impaired, and the epithelium undergoes apoptosis. Interestingly, when VEGF is attenuated, epithelial differentiation still proceeds, as shown by acquisition of both proximal and distal markers. These data show that VEGF co-ordinates epithelial and vascular development. It is required for the development of the lung vasculature and the vasculature is necessary for epithelial proliferation and morphogenesis, but not for cell differentiation.

  6. Characteristics, classification and ordination of riparian plant communities in the Three-Gorges areas

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Sixteen different vegetation types of grassland and shrubland were selected to study the component and diversity of plant species of riparian plant communities along main channel in the Three-Gorges areas. Species richness (s), Simpson index (D), and Shannon-Weiner index (H) were used to study the biodiversity and the hierarchical classification was carried out by the methods of TWINSPAN and DCA ordination. The results showed that the components of flora were complex and dominated by the temperate type in the riparian plant communities. Species diversity was not different between the communities, but Shannon-Weiner indexes of different layers in some grassland were significantly different. TWINSPAN and DCA indicated that riparian plant communities distributed along the gradient of moisture.

  7. High-order solution methods for grey discrete ordinates thermal radiative transfer

    Energy Technology Data Exchange (ETDEWEB)

    Maginot, Peter G., E-mail: maginot1@llnl.gov [Lawrence Livermore National Laboratory, Livermore, CA 94551 (United States); Ragusa, Jean C., E-mail: jean.ragusa@tamu.edu [Department of Nuclear Engineering, Texas A& M University, College Station, TX 77843 (United States); Morel, Jim E., E-mail: morel@tamu.edu [Department of Nuclear Engineering, Texas A& M University, College Station, TX 77843 (United States)

    2016-12-15

    This work presents a solution methodology for solving the grey radiative transfer equations that is both spatially and temporally more accurate than the canonical radiative transfer solution technique of linear discontinuous finite element discretization in space with implicit Euler integration in time. We solve the grey radiative transfer equations by fully converging the nonlinear temperature dependence of the material specific heat, material opacities, and Planck function. The grey radiative transfer equations are discretized in space using arbitrary-order self-lumping discontinuous finite elements and integrated in time with arbitrary-order diagonally implicit Runge–Kutta time integration techniques. Iterative convergence of the radiation equation is accelerated using a modified interior penalty diffusion operator to precondition the full discrete ordinates transport operator.

  8. Municipalities' Priority Problems and Prospect of Establishing Ordinance to Measures for Marginal Hamlets

    Science.gov (United States)

    Nakanishi, Mayumi; Hoshino, Satoshi; Hashimoto, Shizuka; Kuki, Yasuaki

    The problems of Marginal Hamlets are getting worse, in which more than half of the population is over 65 and community-based life is difficult. To contribute to effective policy making, we conducted a questionnaire survey to members of the National Liaison Council of ‘Suigen no Sato’ constituted to share information about problems and effective counter measures for marginal hamlets. Our study clarified that first, most of respondents had common problems such as lack of job-opportunities and animal damage on farm, and second, though most of respondents recognized the effectiveness of selecting target communities in policy implementations, it is difficult for municipal governments to establish such ordinance provided that councilors and those who were not living in areas of policy target wouldn't agree with it. Finally, we pointed out the roles of national and prefectural governments to help municipal governments effectively cope with such entangled situations.

  9. Using Two-Level Factor Analysis to Test for Cluster Bias in Ordinal Data.

    Science.gov (United States)

    Jak, Suzanne; Oort, Frans J; Dolan, Conor V

    2014-01-01

    The test for cluster bias is a test of measurement invariance across clusters in 2-level data. This article examines the true positive rates (empirical power) and false positive rates of the test for cluster bias using the likelihood ratio test (LRT) and the Wald test with ordinal data. A simulation study indicates that the scaled version of the LRT that accounts for nonnormality of the data gives untrustworthy results, whereas the unscaled LRT and the Wald test have acceptable false positive rates and perform well in terms of empirical power rate if the amount of cluster bias is large. The test for cluster bias is illustrated with data from research on teacher-student relations.

  10. Test Statistics and Confidence Intervals to Establish Noninferiority between Treatments with Ordinal Categorical Data.

    Science.gov (United States)

    Zhang, Fanghong; Miyaoka, Etsuo; Huang, Fuping; Tanaka, Yutaka

    2015-01-01

    The problem for establishing noninferiority is discussed between a new treatment and a standard (control) treatment with ordinal categorical data. A measure of treatment effect is used and a method of specifying noninferiority margin for the measure is provided. Two Z-type test statistics are proposed where the estimation of variance is constructed under the shifted null hypothesis using U-statistics. Furthermore, the confidence interval and the sample size formula are given based on the proposed test statistics. The proposed procedure is applied to a dataset from a clinical trial. A simulation study is conducted to compare the performance of the proposed test statistics with that of the existing ones, and the results show that the proposed test statistics are better in terms of the deviation from nominal level and the power.

  11. Medical equipment ordinance and lack of personnel: two contrary factors influencing anesthesia patient safety.

    Science.gov (United States)

    Peter, K; Dieterich, H J

    1991-01-01

    In January 1986, West German legislators enacted the Medical Equipment Ordinance (MedGV) to define specific regulations for both manufacturers and operators of medical equipment and to offer a measure of safety to patients. We describe the history of MedGV, its regulations, and the mechanisms developed to enforce those regulations. We also evaluate its impact on clinical practice in light of the current staff shortages in anesthesia practice and research in Germany. Finally, we focus our discussion on the distinction between improved equipment as a minor factor in critical-incidents and the inadequate manpower as a major factor in anesthesia mishaps. It is unclear what will develop after 1993, when the national states in Europe form a common market.

  12. Intersegmental co-ordination of undulatory movements--a "trailing oscillator" hypothesis.

    Science.gov (United States)

    Matsushima, T; Grillner, S

    1990-10-01

    Intersegmental co-ordination in undulatory locomotion was investigated in the lamprey spinal cord in vitro. It is characterized by a constant phase lag between the activation of consecutive segments. By increasing the excitability (NMDA level) locally, a "travelling wave" could be induced to start in any segment and to be conducted in both rostral and caudal directions. This leading segment, the one with the highest excitability, determined the frequency of all other segments, and the ascending and descending couplings were functionally symmetric. The intersegmental phase lag can be explained by a simple neural mechanism in which a leading oscillator will entrain the adjacent "trailing" segments, which in turn entrain their neighbours and so forth.

  13. Evaluating the implementation of the energy consumption labelling ordinance. Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    Schlomann, B.; Eichhammer, W.; Gruber, E.; Kling, N.; Mannsbart, W.; Stoeckle, F.

    2001-03-01

    The main objective of the study was to examine the present degree of compliance with the Energy Consumption Labelling Ordinance for large household appliances in Germany in an empirical inventory. Concrete proposals to improve the degree of compliance with Directive among manufacturers and retailers were to be elaborated based on this inventory and the analysis of possible deficiencies in implementation and and their causes. A further objective of the study was to examine whether there was an increase in the share of appliance sales in the highest efficiency classes, so as to be able to judge the success of the measures provided in the Directive in accordance with the underlying energy and environmental objective of further reducing energy consumption in households. Furthermore, experience of other European countries in implementing the EU Directive was to be considered. (orig./CB)

  14. Discrete ordinates method for three-dimensional neutron transport equation based on unstructured-meshes

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A discrete ordinates method for a threedimensional first-order neutron transport equation based on unstructured-meshes that avoids the singularity of the second-order neutron transport equation in void regions was derived.The finite element variation equation was obtained using the least-squares method.A three-dimensional transport calculation code was developed.Both the triangular-z and the tetrahedron elements were included.The numerical results of some benchmark problems demonstrated that this method can solve neutron transport problems in unstructuredmeshes very well.For most problems,the error of the eigenvalue and the angular flux is less than 0.3% and 3.0% respectively.

  15. Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis.

    Science.gov (United States)

    Ohazama, A; Courtney, J-M; Sharpe, P T

    2004-03-01

    Osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) are mediators of various cellular interactions, including bone metabolism. We analyzed expression of these three genes during murine odontogenesis from epithelial thickening to cytodifferentiation stages. Opg showed expression in the thickening and bud epithelium. Expression of Opg and Rank was observed in both the internal and the external enamel epithelium as well as in the dental papilla mesenchyme. Although Rankl expression was not detected in tooth epithelium or mesenchyme, it was expressed in pre-osteogenic mesenchymal cells close to developing tooth germs. All three genes were detected in developing dentary bone at P0. The addition of exogenous OPG to explant cultures of tooth primordia produced a delay in tooth development that resulted in reduced mineralization. We propose that the spatiotemporal expression of these molecules in early tooth and bone primordia cells has a role in co-ordinating bone and tooth development.

  16. Study on the Mechanism of mTOR-Mediated Autophagy during Electroacupuncture Pretreatment against Cerebral Ischemic Injury

    Science.gov (United States)

    Wu, Zhou-Quan; Cui, Su-yang; Zhu, Liang

    2016-01-01

    This study is aimed at investigating the association between the electroacupuncture (EA) pretreatment-induced protective effect against early cerebral ischemic injury and autophagy. EA pretreatment can protect cerebral ischemic and reperfusion injuries, but whether the attenuation of early cerebral ischemic injury by EA pretreatment was associated with autophagy is not yet clear. This study used the middle cerebral artery occlusion model to monitor the process of ischemic injury. For rats in the EA pretreatment group, EA pretreatment was conducted at Baihui acupoint before ischemia for 30 min for 5 consecutive days. The results suggested that EA pretreatment significantly increased the expression of autophagy in the cerebral cortical area on the ischemic side of rats. But the EA pretreatment-induced protective effects on the brain could be reversed by the specific inhibitor 3-methyladenine of autophagy. Additionally, the Pearson correlation analysis indicated that the impact of EA pretreatment on p-mTOR (2481) was negatively correlated with its impact on autophagy. In conclusion, the mechanism of EA pretreatment at Baihui acupoint against cerebral ischemic injury is mainly associated with the upregulation of autophagy expression, and its regulation of autophagy may depend on mTOR-mediated signaling pathways. PMID:27547233

  17. Development of a new adaptive ordinal approach to continuous-variable probabilistic optimization.

    Energy Technology Data Exchange (ETDEWEB)

    Romero, Vicente JosÔe; Chen, Chun-Hung (George Mason University, Fairfax, VA)

    2006-11-01

    A very general and robust approach to solving continuous-variable optimization problems involving uncertainty in the objective function is through the use of ordinal optimization. At each step in the optimization problem, improvement is based only on a relative ranking of the uncertainty effects on local design alternatives, rather than on precise quantification of the effects. One simply asks ''Is that alternative better or worse than this one?'' -not ''HOW MUCH better or worse is that alternative to this one?'' The answer to the latter question requires precise characterization of the uncertainty--with the corresponding sampling/integration expense for precise resolution. However, in this report we demonstrate correct decision-making in a continuous-variable probabilistic optimization problem despite extreme vagueness in the statistical characterization of the design options. We present a new adaptive ordinal method for probabilistic optimization in which the trade-off between computational expense and vagueness in the uncertainty characterization can be conveniently managed in various phases of the optimization problem to make cost-effective stepping decisions in the design space. Spatial correlation of uncertainty in the continuous-variable design space is exploited to dramatically increase method efficiency. Under many circumstances the method appears to have favorable robustness and cost-scaling properties relative to other probabilistic optimization methods, and uniquely has mechanisms for quantifying and controlling error likelihood in design-space stepping decisions. The method is asymptotically convergent to the true probabilistic optimum, so could be useful as a reference standard against which the efficiency and robustness of other methods can be compared--analogous to the role that Monte Carlo simulation plays in uncertainty propagation.

  18. Meta-Analysis of Ordinal Data and Its Solution by SAS%有序数据的Meta分析方法及SAS实现

    Institute of Scientific and Technical Information of China (English)

    张天嵩; 熊茜

    2012-01-01

    目的 介绍有序数据的Meta分析方法及其在SAS软件的实现.方法 以实例说明,采用两步法:第一步,基于累积比数模型,采用SAS中的GENMOD过程计算产生每个研究的效应量及其标准误;第二步,采用固定效应模型和随机效应模型以SAS中的MIXED过程进行经典Meta分析.结果 固定效应和随机效应模型Meta分析结果显示,汇总比值比及95%可信区间均为2.853 9(2.106 4,3.864 8).结论 对于有序数据,可以应用SAS中的GENMOD过程和MIXED过程进行Meta分析.%Objective To introduce methodology for undertaking a meta-analysis on ordinal data and its realization in SAS. Methods It was illustrated on an example data by using two-step method. In the first step, it was calculated treatment effect and its standard error for an individual study by using PROC GENMOD in SAS based on cumulative odds models; in the second step, a classical meta-analysis was proposed for fixed and random effect model by using PROC MIXED in SAS. Results Results from the traditional meta-analysis of summary odds ratio and its 95% CI were same 2.853 9(2.106 4,3.864 8) for fixed and random effect model. Conclusions The procedure SAS PROC GENMOD and MIXED were utilized to undertake a meta-analysis on ordinal data.

  19. Digestibility Improvement of Sorted Waste with Alkaline Hydrothermai Pretreatment

    Institute of Scientific and Technical Information of China (English)

    WANG Hao; WANG Hongtao; LU Wenjing; ZHAO Yan

    2009-01-01

    The digestibility of sorted municipal solid waste (MSW) is often limited by the high content of structured green waste. The objectives of this study are to investigate the effect of alkaline hydrothermal pretreatment on the anaerobic digestion of sorted waste and to analyze the biogas production of different parts of the waste. The waste was hydrothermally pretreated in a dilute alkali solution. The hydrolysis product was then incubated in a 500 mL saline bottle to determine the biochemical methane potential (BMP) under mesophilic anaerobic conditions. The optimum hydrothermal condition was 170℃ at 4 g NaOH/100 g solid for one hour. The concentration of chemical oxygen demand (COD) was 13 936 mg/L and the methane yield was 164 mL/g volatile solid (VS) for 6 days incubation at the optimum conditions. The biogas production was increased more than 50% over the control, with the methane conversion ratio on a carbon basis enhanced to 30.6%. The organic part of the sorted waste was mainly kitchen garbage and leaves. Model kitchen garbage completely liquified at 130℃ for one hour had a methane yield of 276 mL/g VS. The alkali addition slightly enhanced the hydrolyzation rate and methane yield. The biogas potential of leaves was improved by pre-treatment at above 150℃ under alkaline conditions.

  20. Patterns of dupuytren disease in fingers : studying correlations with a multivariate ordinal logit model

    NARCIS (Netherlands)

    Lanting, Rosanne M.D.; Nooraee, Nazanin; Werker, Paul M.N.; van den Heuvel, Edwin R.

    BACKGROUND: Dupuytren disease affects fingers in a variable fashion. Knowledge about specific disease patterns (phenotype) based on location and severity of the disease is lacking. METHODS: In this cross-sectional study, 344 primary affected hands with Dupuytren disease were physically examined. The

  1. An ordinal approach to computing with words and the preference-aversion model

    DEFF Research Database (Denmark)

    Franco de los Rios, Camilo Andres; Rodríguez, J. Tinguaro; Montero, Javier

    2014-01-01

    Computing with words (CWW) explores the brain’s ability to handle and evaluate perceptions through language, i.e., by means of the linguistic representation of information and knowledge. On the other hand, standard preference structures examine decision problems through the decomposition of the p...

  2. Patterns of dupuytren disease in fingers : studying correlations with a multivariate ordinal logit model

    NARCIS (Netherlands)

    Lanting, Rosanne M.D.; Nooraee, Nazanin; Werker, Paul M.N.; van den Heuvel, Edwin R.

    2014-01-01

    BACKGROUND: Dupuytren disease affects fingers in a variable fashion. Knowledge about specific disease patterns (phenotype) based on location and severity of the disease is lacking. METHODS: In this cross-sectional study, 344 primary affected hands with Dupuytren disease were physically examined. The

  3. 41 CFR 102-74.351 - If a state or local government has a smoke-free ordinance that is more strict than the smoking...

    Science.gov (United States)

    2010-07-01

    ... government has a smoke-free ordinance that is more strict than the smoking policy for Federal facilities... REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Smoking § 102-74.351 If a state or local government has a smoke-free ordinance that is more strict than the smoking policy for Federal...

  4. Dyslexia and Developmental Co-Ordination Disorder in Further and Higher Education--Similarities and Differences. Does the "Label" Influence the Support Given?

    Science.gov (United States)

    Kirby, Amanda; Sugden, David; Beveridge, Sally; Edwards, Lisa; Edwards, Rachel

    2008-01-01

    Developmental co-ordination disorder (DCD) is a developmental disorder affecting motor co-ordination. The "Diagnostics Statistics Manual"--IV classification for DCD describes difficulties across a range of activities of daily living, impacting on everyday skills and academic performance in school. Recent evidence has shown that…

  5. Oxidative lime pretreatment of Alamo switchgrass.

    Science.gov (United States)

    Falls, Matthew; Holtzapple, Mark T

    2011-09-01

    Previous studies have shown that oxidative lime pretreatment is an effective delignification method that improves the enzymatic digestibility of many biomass feedstocks. The purpose of this work is to determine the recommended oxidative lime pretreatment conditions (reaction temperature, time, pressure, and lime loading) for Alamo switchgrass (Panicum virgatum). Enzymatic hydrolysis of glucan and xylan was used to determine the performance of the 52 studied pretreatment conditions. The recommended condition (110°C, 6.89 bar O(2), 240 min, 0.248 g Ca(OH)(2)/g biomass) achieved glucan and xylan overall yields (grams of sugar hydrolyzed/100 g sugar in raw biomass, 15 filter paper units (FPU)/g raw glucan) of 85.9 and 52.2, respectively. In addition, some glucan oligomers (2.6 g glucan recovered/100 g glucan in raw biomass) and significant levels of xylan oligomers (26.0 g xylan recovered/100 g xylan in raw biomass) were recovered from the pretreatment liquor. Combining a decrystallization technique (ball milling) with oxidative lime pretreatment further improved the overall glucan yield to 90.0 (7 FPU/g raw glucan).

  6. Oxidative lime pretreatment of Dacotah switchgrass.

    Science.gov (United States)

    Falls, Matthew; Sierra-Ramirez, Rocio; Holtzapple, Mark T

    2011-09-01

    Oxidative lime pretreatment increases the enzymatic digestibility of lignocellulosic biomass primarily by removing lignin. In this study, recommended pretreatment conditions (reaction temperature, oxygen pressure, lime loading, and time) were determined for Dacotah switchgrass. Glucan and xylan overall hydrolysis yields (72 h, 15 FPU/g raw glucan) were measured for 105 different reaction conditions involving three different reactor configurations (very short term, short term, and long term). The short-term reactor was the most productive. At the recommended pretreatment condition (120 °C, 6.89 bar O(2), 240 min), it achieved an overall glucan hydrolysis yield of 85.2 g glucan hydrolyzed/100 g raw glucan and an overall xylan yield of 50.1 g xylan hydrolyzed/100 g raw xylan. At this condition, glucan oligomers (1.80 g glucan recovered/100 g glucan in raw biomass) and xylan oligomers (25.20 g xylan recovered/100 g xylan in raw biomass) were recovered from the pretreatment liquor, which compensate for low pretreatment yields.

  7. Genetic effects of some platinum co-ordination complexes on E.coli DNA as revealed by transformation studies

    NARCIS (Netherlands)

    Hoekstra, W.P.M.; Daemen, Toos

    1982-01-01

    E. coli chromosomal DNA was treated with various Pt co-ordination compounds and then used as donor DNA in E. coli transformation. Genetic analysis of transformants obtained with Pt-treated DNA showed effects of cis-diamminedichloroplatinum(II) (cis-Pt(II)) and cis-Pt-dimethyl-1,3-diaminopropane Cl4

  8. The Impact of Outliers on Cronbach's Coefficient Alpha Estimate of Reliability: Ordinal/Rating Scale Item Responses

    Science.gov (United States)

    Liu, Yan; Wu, Amery D.; Zumbo, Bruno D.

    2010-01-01

    In a recent Monte Carlo simulation study, Liu and Zumbo showed that outliers can severely inflate the estimates of Cronbach's coefficient alpha for continuous item response data--visual analogue response format. Little, however, is known about the effect of outliers for ordinal item response data--also commonly referred to as Likert, Likert-type,…

  9. Application of Multimedia Technology to Study the Ordinal Competences of Children from 3 to 7 Years Old

    Science.gov (United States)

    Hernandez, Pedro; Gonzalez, Jose Luis

    2011-01-01

    The main purpose of this paper is to present an ongoing research study on the evolution of pre-numerical and pre-inductive levels of ordinal thought in students from three to seven years old. Our methodology is based on multimedia technology, an automatic and objective record of the data and minimal interaction between students and researcher. A…

  10. The Impact of Outliers on Cronbach's Coefficient Alpha Estimate of Reliability: Ordinal/Rating Scale Item Responses

    Science.gov (United States)

    Liu, Yan; Wu, Amery D.; Zumbo, Bruno D.

    2010-01-01

    In a recent Monte Carlo simulation study, Liu and Zumbo showed that outliers can severely inflate the estimates of Cronbach's coefficient alpha for continuous item response data--visual analogue response format. Little, however, is known about the effect of outliers for ordinal item response data--also commonly referred to as Likert, Likert-type,…

  11. A social simulation-game to explore future co-ordination in knowledge networks at the Amsterdam Police Force

    NARCIS (Netherlands)

    Van Laere, J.; De Vreede, G. J.; Sol, H. G.

    2006-01-01

    The 32 autonomous neighbourhood teams of the Amsterdam Police Force need to utilise each other's knowledge and expertise to deal with the variety and complexity of their daily work assignments. However, despite the creation of organisation wide knowledge networks, communication, co-ordination and kn

  12. Fractal kinetic analysis of the enzymatic saccharification of CO2 laser pretreated corn stover.

    Science.gov (United States)

    Tian, Shuang-Qi; Ma, Sen; Wang, Xin-Wei; Zhang, Zheng-Nan

    2013-10-15

    The enzymatic hydrolyses of laser pretreated corn stover as a novel pretreatment method were examined to establish a simplified kinetic model for the complicated hydrolysis process. The time dependence of the total reducing sugars amount was closely related to the amounts of cellulosic materials and amounts of cellulase. The evaluated model fitted very well with the experimental data of enzymatic hydrolysis of laser pretreated corn stover under different conditions, including cellulase loading, nature of substrate, substrate loading in the reaction medium. The results indicated that the complex kinetics of cellulase enzymatic saccharification could be assessed with the fractal kinetic model. The cellulase enzymatic reaction process was effectively predicted and controlled with the kinetic model. The result showed that the model could effectively reflect dynamic process of enzyme hydrolysis.

  13. Effects of various pretreatments on biohydrogen production from sewage sludge

    Institute of Scientific and Technical Information of China (English)

    XIAO BenYi; LIU JunXin

    2009-01-01

    The sewage sludge of wastewater treatment plant is a kind of biomass which contains many organics,mainly carbohydrates and proteins. Four pretreatments, acid pretreatment, alkaline pretreatment,thermal pretreatment and ultrasonic pretreatment, were used to enhance biohydrogen production from sewage sludge. The experimental results showed that the four pretreatments could all increase the soluble chemical oxygen demand (SCOD) of sludge and decrease the dry solid (DS) and volatile solid(VS) because the pretreatments could disrupt the floc structure and even the microbial cells of sludge.The results of batch anaerobic fermentation experiments demonstrated that all of the four pretreat-ments could select hydrogen-producing microorganisms from the microflora of sludge and enhance the hydrogen production. The hydrogen yield of the alkaline pretreated sludge at initial pH of 11.5 was the maximal (11.68 mL H2/g VS) and that of the thermal pretreated sludge was the next (8.62 mL H2/g VS).The result showed that the hydrogen yield of pretreated sludge was correlative with its SCOD. The hydrogen yields of acid pretreated sludge and alkaline pretreated sludge were also influenced by their initial pH. No methane could be detected in the anaerobic fermentation of alkaline pretreated sludge and thermal pretreated sludge, which suggested that these pretreatments could fully inhibit the activity of methanogens. The volatile fatty acids (VFA) production in anaerobic fermentation of alkaline pretreated sludge was the maximum and the next is that of thermal pretreated sludge.

  14. Generalized linear models for categorical and continuous limited dependent variables

    CERN Document Server

    Smithson, Michael

    2013-01-01

    Introduction and OverviewThe Nature of Limited Dependent VariablesOverview of GLMsEstimation Methods and Model EvaluationOrganization of This BookDiscrete VariablesBinary VariablesLogistic RegressionThe Binomial GLMEstimation Methods and IssuesAnalyses in R and StataExercisesNominal Polytomous VariablesMultinomial Logit ModelConditional Logit and Choice ModelsMultinomial Processing Tree ModelsEstimation Methods and Model EvaluationAnalyses in R and StataExercisesOrdinal Categorical VariablesModeling Ordinal Variables: Common Practice versus Best PracticeOrdinal Model AlternativesCumulative Mod

  15. Impact of co-pretreatment of calcium hydroxide and steam explosion on anaerobic digestion efficiency with corn stover.

    Science.gov (United States)

    Ji, Jinli; Zhang, Jiyu; Yang, Liutianyi; He, Yanfeng; Zhang, Ruihong; Liu, Guangqing; Chen, Chang

    2016-09-29

    Anaerobic digestion (AD) is an effective way to utilize the abundant resource of corn stover (CS). In this light, Ca(OH)2 pretreatment alone, steam explosion (SE) pretreatment alone, and co-pretreatment of Ca(OH)2 and SE were applied to improve the digestion efficiency of CS. Results showed that AD of co-pretreated CS with 1.0% Ca(OH)2 and SE at 1.5 MPa achieved the highest cumulative methane yield of [Formula: see text], which was 61.54% significantly higher (p pretreatment enhanced from 43.03% to 69.52%. Methane yield could be well fitted by the first-order model and the modified Gompertz model. In addition, composition and structural changes of CS after pretreatment were analyzed by a fiber analyzer, scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. The validated results indicated that co-pretreatment of Ca(OH)2 and SE was efficient to improve the digestion performance of CS and might be a suitable method for agricultural waste pretreatment in the future AD industry.

  16. Pretreatment of Corn Stalk by Steam Explosion

    Institute of Scientific and Technical Information of China (English)

    邵自强; 田永生; 谭惠民

    2003-01-01

    A steam explosion pretreatment, which is one of the best ways of pretreating plant stalk, is applied at various severities to corn stalk. It could effectively modify the super-molecular structure of corn stalk and defibrating corn stalk into individual components. The relationship between yield of reducing sugar and the operating conditions, including temperature, pressure of steam explosion pretreatment and acidity, is also established. Experimental results prove that the steam explosion substantially increases the yield of reducing sugar, and the optimal condition for steam explosion is as follows: the pressure is 2.0 MPa, the pressure-retaining time 300 s, the initial acid concentration 1% and the acid treatment time 24 h.

  17. Pretreatment imaging of peripheral vascular malformations

    Directory of Open Access Journals (Sweden)

    Johnson JB

    2014-10-01

    Full Text Available Joshua B Johnson, Petrice M Cogswell, Michael A McKusick, Larry A Binkovitz, Stephen J Riederer, Phillip M Young Department of Radiology, Mayo Clinic, Rochester, MN, USA Abstract: Peripheral vascular malformations (VMs are complex and diverse vascular lesions which require individualized pretreatment planning. Pretreatment imaging using various modalities, especially magnetic resonance imaging and time-resolved magnetic resonance angiography, is a valuable tool for classifying peripheral VMs to allow proper diagnosis, demonstrate complete extent, identify the nidus, and distinguish between low-flow and high-flow dynamics that determines the treatment approach. We discuss pretreatment imaging findings in four patients with peripheral VMs and how diagnostic imaging helped guide management. Keywords: time-resolved MRA, cartesian acquisition with projection-like reconstruction, endovascular treatment, magnetic resonance angiography

  18. El aprendizaje del número natural en un contexto ordinal en la Educación Infantil

    Directory of Open Access Journals (Sweden)

    Elisa Hernández Gutiérrez

    2013-07-01

    Full Text Available Con el objetivo de que los alumnos empleen los números naturales en su aspecto ordinal, realizamos la actividad “El tren” con niños de 5-6 años. En ella, un alumno debe comunicar por escrito la posición de un objeto escondido en uno de los vagones de un tren a un compañero que no ha visto dónde ha sido introducido dicho objeto. La estrategia necesaria para ganar el juego es el conteo y el uso del número natural en su sentido ordinal, tanto en la elaboración del mensaje como en su interpretación. Analizamos la puesta en marcha de esta estrategia por parte de los niños, los resultados obtenidos y cómo se puede llevar a cabo el proceso de comunicación con las familias cuando se desarrollan este tipo de actividades en el aula.Palabras clave: Educación Infantil, Matemáticas, Números naturales, Números ordinales, Teoría de Situaciones Didácticas, Rincones, Comunicación con familias.Learning of natural numbers in an ordinal context in Early Childhood Education. In order for students to use the natural numbers in ordinal aspect, we do the activity "The Train" with 5-6 year old children. The activity consists of a student who must communicate by writing the position of an object. The object is hidden in one of the carriages of a train. The classmate has not seen where that object has been introduced. The strategy for winning the game is counting and using of ordinal numbers, in the creation of the message and in its interpretation. We analyze the implementation of this strategy by the children, the results and how to carry out the process of communication with families when developing these activities in the classroom.

  19. A Thermodynamic Model for Predicting Phosphorus Partition between CaO-based Slags and Hot Metal during Hot Metal Dephosphorization Pretreatment Process Based on the Ion and Molecule Coexistence Theory

    Science.gov (United States)

    Yang, Xue-min; Li, Jin-yan; Chai, Guo-ming; Duan, Dong-ping; Zhang, Jian

    2016-08-01

    A thermodynamic model for predicting phosphorus partition L P between a CaO-based slags and hot metal during hot metal dephosphorization pretreatment process has been developed based on the ion and molecule coexistence theory (IMCT), i.e., the IMCT- L P model. The reaction abilities of structural units or ion couples in the CaO-based slags have been represented by the calculated mass action concentrations N i through the developed IMCT- N i model based on the IMCT. The developed IMCT- L P model has been verified to be valid through comparing with the measured L P as well as the predicted L P by two reported L P models from the literature. Besides the total phosphorus partition L P between the CaO-based slag and hot metal, the respective phosphorus partitions L P, i of nine dephosphorization products as P2O5, 3FeO·P2O5, 4FeO·P2O5, 2CaO·P2O5, 3CaO·P2O5, 4CaO·P2O5, 2MgO·P2O5, 3MgO·P2O5, and 3MnO·P2O5 can also be accurately predicted by the developed IMCT- L P model. The formed 3CaO·P2O5 accounts for 99.20 pct of dephosphorization products comparing with the generated 4CaO·P2O5 for 0.08 pct. The comprehensive effect of CaO+Fe t O, which can be described by the mass percentage ratio (pct Fe t O)/(pct CaO) or the mass action concentration ratio N_{Fe}t O/N_{Fe}t O N_{CaO}. N_{CaO}} as well as the mass percentage product (pct Fe t O) × (pct CaO) or the mass action concentration product N_{{{{Fe}}t {{O}}}}5 × N_{{CaO}}3 , controls dephosphorization ability of the CaO-based slags. A linear relationship of L P against (pct Fe t O)/(pct CaO) can be correlated compared with a parabolic relationship of L P against N_{Fe}t O/N_{Fe}t O N_{CaO}. N_{CaO}, while the linear relationship of L P against (pct Fe t O) × (pct CaO) or N_{Fe}t O5 × N_{CaO}3 can be established. Thus, the mass percentage product (pct Fe t O) × (pct CaO) and the mass action concentration product N_{Fe}t O5 × N_{CaO}3 are recommended to represent the comprehensive effect of CaO+Fe t O on

  20. Possibilities and evaluation of straw pretreatment

    DEFF Research Database (Denmark)

    Knudsen, Niels Ole; Jensen, Peter Arendt; Sander, Bo

    1998-01-01

    Biomass utilisation by cofiring of straw in a pulverised coal fire boiler is economically attractive compared to dedicated straw fired plants. However, the high content of potassium and chloride impedes utilisation of the fly ash, deactivates the de NOx catalysts in the flue gas cleaning system...... and may also lead to increased deposit formation. A pretreatment process is required to solve the problems. In this paper two pretreatment processes are considred, one based on straw wash and another based on pyrolysis and char wash. To evaluate and compare the processes, laboratory and technical...

  1. Pretreatment Capabilities and Benefits of Electrocoagulation

    Science.gov (United States)

    2004-12-01

    PRETREATMENT CAPABILITIES AND BENEFITS OF ELECTROCOAGULATION Michael Mickley Mickley & Associates Boulder, Colorado...DATES COVERED - 4. TITLE AND SUBTITLE Pretreatment Capabilities and Benefits of Electrocoagulation 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...4 2.1 Background for Electrocoagulation Technology ………………………. 4 2.1.1 Applications ……………………………………………………. 4 2.1.2

  2. Microbial pretreatment of cotton stalks by Phanerochaete chrysosporium for bioethanol production

    Science.gov (United States)

    Shi, Jian

    .04% for SmC and SSC pretreated samples, respectively) compared with untreated cotton stalk samples (17.93%). Washing of pretreated cotton stalks alone caused no significant increase in cellulose conversion. However, a heat treatment (autoclaving) followed by washing remarkably improved (Penzyme production, and oxygen uptake associated with the growth of P. chrysosporium during 14 days fungal pretreatment were developed. For SmC pretreatment, model parameters were estimated by nonlinear regression and validated using an independent set of experimental data. Models yielded sufficiently accurate predictions for holocellulose consumption (R2=0.9772 and 0.9837, 1d and 3d oxygen flushing, respectively), lignin degradation (R2=0.9879 and 0.8682) and ligninolytic enzyme production (R2=0.8135 and 0.9693) under both 1 and 3d oxygen flushing conditions. However, the prediction capabilities for fungal growth (1d and 3d), cellulase production (3d) and oxygen uptake (3d) were limited. For SSC, the models were established in three phases (I: day 0-4, II: day 4-7, III: day 7-14). After validation it was shown that the developed models can yield sufficiently accurate predictions for fungal growth (R 2=0.9724), holocellulose consumption (R2=0.9686), lignin degradation (R2=0.9309) and ligninolytic enzyme production (R2=0.9203); however predictions of cellulase production were fair (R2=0.6133). Although significant delignification occurred during fungal pretreatment indicating the presence of ligninolytic enzymes, common spectrophotometric enzyme assays failed to detect lignin peroxidase (LiP) and manganese peroxidase (MnP) activities in fungal pretreatment cultures. Efforts were made to overcome the drawbacks of standardized assays by performing protein gel electrophoresis and crude enzyme delignification studies. Results from this research are expected to be beneficial in the development of pretreatment technologies that are environment friendly and utilize naturally occurring

  3. Using ordinal logistic regression to evaluate the performance of laser-Doppler predictions of burn-healing time

    Directory of Open Access Journals (Sweden)

    Pape Sarah A

    2009-02-01

    Full Text Available Abstract Background Laser-Doppler imaging (LDI of cutaneous blood flow is beginning to be used by burn surgeons to predict the healing time of burn wounds; predicted healing time is used to determine wound treatment as either dressings or surgery. In this paper, we do a statistical analysis of the performance of the technique. Methods We used data from a study carried out by five burn centers: LDI was done once between days 2 to 5 post burn, and healing was assessed at both 14 days and 21 days post burn. Random-effects ordinal logistic regression and other models such as the continuation ratio model were used to model healing-time as a function of the LDI data, and of demographic and wound history variables. Statistical methods were also used to study the false-color palette, which enables the laser-Doppler imager to be used by clinicians as a decision-support tool. Results Overall performance is that diagnoses are over 90% correct. Related questions addressed were what was the best blood flow summary statistic and whether, given the blood flow measurements, demographic and observational variables had any additional predictive power (age, sex, race, % total body surface area burned (%TBSA, site and cause of burn, day of LDI scan, burn center. It was found that mean laser-Doppler flux over a wound area was the best statistic, and that, given the same mean flux, women recover slightly more slowly than men. Further, the likely degradation in predictive performance on moving to a patient group with larger %TBSA than those in the data sample was studied, and shown to be small. Conclusion Modeling healing time is a complex statistical problem, with random effects due to multiple burn areas per individual, and censoring caused by patients missing hospital visits and undergoing surgery. This analysis applies state-of-the art statistical methods such as the bootstrap and permutation tests to a medical problem of topical interest. New medical findings are

  4. Enhancement of biogas production from microalgal biomass through cellulolytic bacterial pretreatment.

    Science.gov (United States)

    Kavitha, S; Subbulakshmi, P; Rajesh Banu, J; Gobi, Muthukaruppan; Tae Yeom, Ick

    2017-06-01

    Generation of bioenergy from microalgal biomass has been a focus of interest in recent years. The recalcitrant nature of microalgal biomass owing to its high cellulose content limits methane generation. Thus, the present study investigates the effect of bacterial-based biological pretreatment on liquefaction of the microalga Chlorella vulgaris prior to anaerobic biodegradation to gain insights into energy efficient biomethanation. Liquefaction of microalgae resulted in a higher biomass stress index of about 18% in the experimental (pretreated with cellulose-secreting bacteria) vs. 11.8% in the control (non-pretreated) group. Mathematical modelling of the biomethanation studies implied that bacterial pretreatment had a greater influence on sustainable methane recovery, with a methane yield of about 0.08 (g Chemical Oxygen Demand/g Chemical Oxygen Demand), than did control pretreatment, with a yield of 0.04 (g Chemical Oxygen Demand/g Chemical Oxygen Demand). Energetic analysis of the proposed method of pretreatment showed a positive energy ratio of 1.04. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Improvement of methane production from waste paper by pretreatment with rumen fluid.

    Science.gov (United States)

    Baba, Yasunori; Tada, Chika; Fukuda, Yasuhiro; Nakai, Yutaka

    2013-01-01

    Cellulose hydrolysis is the rate-limiting step in anaerobic digestion. In the present study, waste paper was used as a model of cellulosic biomass and was pretreated with rumen fluid prior to methane production. To achieve a high methane yield, the reaction time of the pretreatment was examined. Waste paper was soaked with rumen fluid for 6 and 24h at 37 °C. Various volatile fatty acids, especially acetate, were produced by the pretreatment. Semicontinuous methane production was carried out over a 20-day period. The best daily methane yield was obtained by the 6-h pretreatment. The amount was 2.6 times higher than that of untreated paper, which resulted in 73.4% of the theoretical methane yield. During methane production, the cellulose, hemicellulose and lignin degradabilities were improved by the pretreatment. Pretreatment by rumen fluid is therefore a powerful method to accelerate the methane yield from a cellulosic biomass. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. A study on alkali pretreatment conditions of sorghum stem for maximum sugar recovery using statistical approach

    Directory of Open Access Journals (Sweden)

    Nikzad Maryam

    2014-01-01

    Full Text Available Bioethanol production from lignocellulosic biomass provides an alternative energy-production system. Sorghum bicolor stem is a cheap agro-waste for bioethanol production. In this study, response surface methodology (RSM was used to optimize alkali pretreatment conditions for sorghum bicolor stem with respect to substrate concentration, NaOH concentration and pretreatment time based on a central composite rotary design. The main goal was to achieve the highest glucose and xylose yields after enzymatic hydrolysis. Under optimum conditions of pretreatment i.e. time 60.4 min, solid loading 4.2%, and NaOH concentration 1.7%, yields of 98.94% g glucose/g cellulose and 65.14% g xylose/g hemicelluloses were obtained. The results of a confirmation experiment under the optimal conditions agreed well with model predictions. Pretreatment of sorghum bicolor stem at the optimum condition increased the glucose and xylose yields by 7.14 and 3.02 fold, respectively. Alkali pretreatment showed to be a great choice for the pretreatment of sorghum bicolor stem.

  7. Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis.

    Science.gov (United States)

    Wu, Xue-Ming; Todo, Hiroaki; Sugibayashi, Kenji

    2007-04-02

    A combination of microneedle pretreatment and iontophoresis was evaluated for the potential to increase skin permeation of drugs. Two model compounds with low and high molecular D(2)O and fluorescein isothiocyanate (FITC)-dextrans (FD-4, FD-10, FD-40, FD-70 and FD-2000; average molecular weight of 3.8, 10.1, 39.0, 71.2 and 200.0 kDa), respectively, were used and the effect of microneedle pretreatment and iontophoresis on their in vitro permeability was evaluated using excised hairless rat skin with a 2-chamber diffusion cell. Convective solvent flow through the skin was measured using a set of calibrated capillaries attached to the diffusion cell. The following results were obtained: (1) convective solvent flow (electroosmosis) during iontophoresis through microneedle-pretreated skin, 2.62+/-0.32 microL/cm(2)/h, was almost the same as through intact skin, 2.71+/-0.25 microL/cm(2)/h, and (2) the combination of microneedle pretreatment and subsequent iontophoresis significantly enhanced FD flux compared with microneedle pretreatment alone or iontophoresis alone, whereas no synergistic effect was found on the flux of D(2)O. These results suggest that the combination of iontophoresis with microneedle pretreatment may be a useful means to increase skin permeation of high molecular compounds.

  8. Co-ordination of satellite and data programs: The committee on earth observation satellites' approach

    Science.gov (United States)

    Embleton, B. J. J.; Kingwell, J.

    1997-01-01

    Every year, an average of eight new civilian remote sensing satellite missions are launched. Cumulatively, over 250 such missions, each with a cost equivalent in current value to between US 100 million to US 1000 million, have been sponsored by space agencies in perhaps two dozen countries. These missions produce data and information products which are vital for informed decision making all over the world, on matters relating to natural resource exploitation, health and safety, sustainable national development, infrastructure planning, and a host of other applications. By contributing to better scientific understanding of global changes in the atmosphere, land surface, oceans and ice caps, these silently orbiting sentinels in the sky make it possible for governments and industries to make wiser environmental policy decisions and support the economic development needs of humanity. The international Committee on Earth Observation Satellites (CEOS) is the premier world body for co-ordinating and planning civilian satellite missions for Earth observation. Through its technical working groups and special task teams, it endeavours to: • maximise the international benefits from Earth observation satellites; and • harmonise practice in calibration, validation, data management and information systems for Earth observation. CEOS encompasses not only space agencies (data providers), but also the great international scientific and operational programs which rely on Earth science data from space. The user organisations affiliated with CEOS, together with the mission operators, attempt to reconcile user needs with the complex set of considerations — including national interests, cost, schedule — which affect the undertaking of space missions. Without such an internationally co-ordinated consensual approach, there is a much greater risk of waste through duplication, and of missed opportunity, or through the absence of measurements of some vital physical or biological

  9. Pretreatment on Corn Stover with Low Concentration of Formic Acid

    DEFF Research Database (Denmark)

    Xu, Jian; Thomsen, Mette Hedegaard; Thomsen, Anne Belinda

    2009-01-01

    the cellulose easily degraded into sugars and further fermented to ethanol. In this work, hydrothermal pretreatment on corn stover at 195 degrees for 15 min with and without lower concentration of formic acid was compared in terms of sugar recoveries and ethanol fermentation. For pretreatment with formic acid...... pretreatment without formic acid. Toxicity tests of liquor parts showed that there were no inhibitions found for both pretreatment conditions. After simultaneous saccharification and fermentation (SSF) of the pretreated corn stover with Baker's yeast, the highest ethanol yield of 76.5% of the theoretical...... was observed from corn stover pretreated at 195 degrees for 15min with formic acid....

  10. Pre-treatment step with Leuconostoc mesenteroides or L. pseudomesenteroides strains removes furfural from Zymomonas mobilis ethanolic fermentation broth.

    Science.gov (United States)

    Hunter, William J; Manter, Daniel K

    2014-10-01

    Furfural is an inhibitor of growth and ethanol production by Zymomonas mobilis. This study used a naturally occurring (not GMO) biological pre-treatment to reduce that amount of furfural in a model fermentation broth. Pre-treatment involved inoculating and incubating the fermentation broth with strains of Leuconostoc mesenteroides or Leuconostoc pseudomesenteroides. The Leuconostoc strains converted furfural to furfuryl alcohol without consuming large amounts of dextrose in the process. Coupling this pre-treatment to ethanolic fermentation reduced furfural in the broth and improved growth, dextrose uptake and ethanol formation. Pre-treatment permitted ethanol formation in the presence of 5.2 g L(-1) furfural, which was otherwise inhibitive. The pre-treatment and presence of the Leuconostoc strains in the fermentation broth did not interfere with Z. mobilis ethanolic fermentation or the amounts of ethanol produced. The method suggests a possible technique for reducing the effect that furfural has on the production of ethanol for use as a biofuel.

  11. Sugarcane bagasse pretreatment using three imidazolium-based ionic liquids; mass balances and enzyme kinetics

    Directory of Open Access Journals (Sweden)

    Karatzos Sergios

    2012-08-01

    Full Text Available Abstract Background Effective pretreatment is key to achieving high enzymatic saccharification efficiency in processing lignocellulosic biomass to fermentable sugars, biofuels and value-added products. Ionic liquids (ILs, still relatively new class of solvents, are attractive for biomass pretreatment because some demonstrate the rare ability to dissolve all components of lignocellulosic biomass including highly ordered (crystalline cellulose. In the present study, three ILs, 1-butyl-3-methylimidazolium chloride ([C4mim]Cl, 1-ethyl-3-methylimidazolium chloride ([C2mim]Cl, 1-ethyl-3-methylimidazolium acetate ([C2mim]OAc are used to dissolve/pretreat and fractionate sugarcane bagasse. In these IL-based pretreatments the biomass is completely or partially dissolved in ILs at temperatures greater than 130°C and then precipitated by the addition of an antisolvent to the IL biomass mixture. For the first time mass balances of IL-based pretreatments are reported. Such mass balances, along with kinetics data, can be used in process modelling and design. Results Lignin removals of 10% mass of lignin in bagasse with [C4mim]Cl, 50% mass with [C2mim]Cl and 60% mass with [C2mim]OAc, are achieved by limiting the amount of water added as antisolvent to 0.5 water:IL mass ratio thus minimising lignin precipitation. Enzyme saccharification (24 h, 15FPU yields (% cellulose mass in starting bagasse from the recovered solids rank as: [C2mim]OAc(83% > >[C2mim]Cl(53% = [C4mim]Cl(53%. Composition of [C2mim]OAc-treated solids such as low lignin, low acetyl group content and preservation of arabinosyl groups are characteristic of aqueous alkali pretreatments while those of chloride IL-treated solids resemble aqueous acid pretreatments. All ILs are fully recovered after use (100% mass as determined by ion chromatography. Conclusions In all three ILs regulated addition of water as an antisolvent effected a polysaccharide enriched precipitate since some of the lignin

  12. Simulation of the ozone pretreatment of wheat straw.

    Science.gov (United States)

    Bhattarai, Sujala; Bottenus, Danny; Ivory, Cornelius F; Gao, Allan Haiming; Bule, Mahesh; Garcia-Perez, Manuel; Chen, Shulin

    2015-11-01

    Wheat straw is a potential feedstock in biorefinery for sugar production. However, the cellulose, which is the major source of sugar, is protected by lignin. Ozonolysis deconstructs the lignin and makes cellulose accessible to enzymatic digestion. In this study, the change in lignin concentration with different ozonolysis times (0, 1, 2, 3, 5, 7, 10, 15, 20, 30, 60min) was fit to two different kinetic models: one using the model developed by Garcia-Cubero et al. (2012) and another including an outer mass transfer barrier or "cuticle" region where ozone mass transport is reduced in proportion to the mass of unreacted insoluble lignin in the cuticle. The kinetic parameters of two mathematical models for predicting the soluble and insoluble lignin at different pretreatment time were determined. The results showed that parameters derived from the cuticle-based model provided a better fit to experimental results compared to a model without a cuticle layer.

  13. Specular reflection treatment for the 3D radiative transfer equation solved with the discrete ordinates method

    Energy Technology Data Exchange (ETDEWEB)

    Le Hardy, D. [Université de Nantes, LTN UMR CNRS 6607 (France); Favennec, Y., E-mail: yann.favennec@univ-nantes.fr [Université de Nantes, LTN UMR CNRS 6607 (France); Rousseau, B. [Université de Nantes, LTN UMR CNRS 6607 (France); Hecht, F. [Sorbonne Universités, UPMC Université Paris 06, UMR 7598, inria de Paris, Laboratoire Jacques-Louis Lions, F-75005, Paris (France)

    2017-04-01

    The contribution of this paper relies in the development of numerical algorithms for the mathematical treatment of specular reflection on borders when dealing with the numerical solution of radiative transfer problems. The radiative transfer equation being integro-differential, the discrete ordinates method allows to write down a set of semi-discrete equations in which weights are to be calculated. The calculation of these weights is well known to be based on either a quadrature or on angular discretization, making the use of such method straightforward for the state equation. Also, the diffuse contribution of reflection on borders is usually well taken into account. However, the calculation of accurate partition ratio coefficients is much more tricky for the specular condition applied on arbitrary geometrical borders. This paper presents algorithms that calculate analytically partition ratio coefficients needed in numerical treatments. The developed algorithms, combined with a decentered finite element scheme, are validated with the help of comparisons with analytical solutions before being applied on complex geometries.

  14. Improving Your Exploratory Factor Analysis for Ordinal Data: A Demonstration Using FACTOR

    Directory of Open Access Journals (Sweden)

    James Baglin

    2014-06-01

    Full Text Available Exploratory factor analysis (EFA methods are used extensively in the field of assessment and evaluation. Due to EFA's widespread use, common methods and practices have come under close scrutiny. A substantial body of literature has been compiled highlighting problems with many of the methods and practices used in EFA, and, in response, many guidelines have been proposed with the aim to improve application. Unfortunately, implementing recommended EFA practices has been restricted by the range of options available in commercial statistical packages and, perhaps, due to an absence of clear, practical - how-to' demonstrations. Consequently, this article describes the application of methods recommended to get the most out of your EFA. The article focuses on dealing with the common situation of analysing ordinal data as derived from Likert-type scales. These methods are demonstrated using the free, stand-alone, easy-to-use and powerful EFA package FACTOR (http://psico.fcep.urv.es/utilitats/factor/, Lorenzo-Seva & Ferrando, 2006. The demonstration applies the recommended techniques using an accompanying dataset, based on the Big 5 personality test. The outcomes obtained by the EFA using the recommended procedures through FACTOR are compared to the default techniques currently available in SPSS.

  15. Performance of the Adaptive Collision Source (ACS) Method for Discrete Ordinates in Parallel Environments

    Science.gov (United States)

    Walters, William J.; Haghighat, Alireza

    2014-06-01

    A new collision source method has been developed to solve the Linear Boltzmann Equation (LBE) more efficiently by adaptation of the angular quadrature order. The angular adaptation method is unique in that the flux from each scattering source iteration is obtained separately, with potentially a different quadrature order. This allows for an optimal use of processing power, by using a high order quadrature for the first few iterations that need it, before shifting to lower order quadratures for the remaining iterations. This is essentially an extension of the first collision source method, and we call it the adaptive collision source method (ACS). The ACS methodolog y has been implemented in the TITAN discrete ordinates code, and has shown a speedup of 2-3 on a test problem, with very little loss of accuracy (within a provided adaptive tolerance). Further, the code has been extended to work in parallel environments by angular decomposition. Although the method requires increased parallel communication, tests have shown excellent scalability, with parallel fractions of up to 99%.

  16. Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling.

    Science.gov (United States)

    Kurosaka, Hiroshi; Trainor, Paul A; Leroux-Berger, Margot; Iulianella, Angelo

    2015-01-01

    Cranial nerves govern sensory and motor information exchange between the brain and tissues of the head and neck. The cranial nerves are derived from two specialized populations of cells, cranial neural crest cells and ectodermal placode cells. Defects in either cell type can result in cranial nerve developmental defects. Although several signaling pathways are known to regulate cranial nerve formation our understanding of how intercellular signaling between neural crest cells and placode cells is coordinated during cranial ganglia morphogenesis is poorly understood. Sonic Hedgehog (Shh) signaling is one key pathway that regulates multiple aspects of craniofacial development, but whether it co-ordinates cranial neural crest cell and placodal cell interactions during cranial ganglia formation remains unclear. In this study we examined a new Patched1 (Ptch1) loss-of-function mouse mutant and characterized the role of Ptch1 in regulating Shh signaling during cranial ganglia development. Ptch1(Wig/ Wig) mutants exhibit elevated Shh signaling in concert with disorganization of the trigeminal and facial nerves. Importantly, we discovered that enhanced Shh signaling suppressed canonical Wnt signaling in the cranial nerve region. This critically affected the survival and migration of cranial neural crest cells and the development of placodal cells as well as the integration between neural crest and placodes. Collectively, our findings highlight a novel and critical role for Shh signaling in cranial nerve development via the cross regulation of canonical Wnt signaling.

  17. Bonegilla Heritage Park: Contesting and Co-ordinating a Public History Site

    Directory of Open Access Journals (Sweden)

    Alexandra Dellios

    2012-10-01

    Full Text Available Since the 1980s, efforts to publically commemorate the former migrant training and reception centre of Bonegilla, while intermittent, have increased. I am referring to: reunions and anniversaries, state and national heritage listings, the erection of museum displays, temporary and touring exhibitions, the on-site Heritage Park, and forms of popular culture. For the national audience, as well as several ethnic communities, Bonegilla now plays a role in the collective imagination of the post-war period and the migrant journey. Furthermore, the nature of Bonegilla’s public representation has evolved since the late 1980s. Bonegilla has become much more than a place of personal migrant memory, and its previous negative connotations in the public arena have been erased. This public evolution is linked to much wider processes in our national history. This article thus explores the contestation and co-ordination of collective memories—that is, multiple narratives of Bonegilla’s past, which, while in constant dialogue with each other, are framed and sanctioned by the limits of Australian multiculturalism and heritage discourses. While the earliest efforts to commemorate Bonegilla might be typified as ‘participatory’ and vernacular, they might now be described in reference to ‘retrospective commemoration’, in which Bonegilla’s public history is framed by state-sanctioned narratives and other attendant discursive frameworks.

  18. c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production.

    Science.gov (United States)

    Dunn, Sianadh; Lombardi, Olivia; Cowling, Victoria H

    2017-02-01

    The mRNA cap is a structure added to RNA pol II transcripts in eukaryotes, which recruits factors involved in RNA processing, nuclear export and translation initiation. RNA guanine-7 methyltransferase (RNMT)-RNA-activating miniprotein (RAM), the mRNA cap methyltransferase complex, completes the basic functional mRNA cap structure, cap 0, by methylating the cap guanosine. Here, we report that RNMT-RAM co-ordinates mRNA processing with ribosome production. Suppression of RNMT-RAM reduces synthesis of the 45S ribosomal RNA (rRNA) precursor. RNMT-RAM is required for c-Myc expression, a major regulator of RNA pol I, which synthesises 45S rRNA. Constitutive expression of c-Myc restores rRNA synthesis when RNMT-RAM is suppressed, indicating that RNMT-RAM controls rRNA production predominantly by controlling c-Myc expression. We report that RNMT-RAM is recruited to the ribosomal DNA locus, which may contribute to rRNA synthesis in certain contexts. © 2017 The Author(s).

  19. L'ordine del mondo le simmetrie in fisica da Aristotele a Higgs

    CERN Document Server

    Barone, Vincenzo

    2013-01-01

    Il mondo ci appare come una lunga serie di contingenze locali: ogni fatto accade per ragioni sue e quindi ogni previsione relativa al fatto successivo sembra azzardata. C'è però un altro modo di guardare il mondo, ed è quello fondato sulle regolarità intrinseche, sulle trame ordinate della sua tessitura sottile. In fisica il discorso sulla struttura del mondo giunge a noi addirittura da Anassimandro, ma è con Einstein che si fa strada prepotentemente l'idea di necessità, o di inevitabilità, nel mondo fisico. È con la relatività ristretta, nel 1905, che per la prima volta entra a far parte della fisica il concetto di simmetria come elemento fondamentale della spiegazione del mondo. Da Einstein in poi, il mondo apparirà dotato di una sua struttura intrinseca, che permette lo sviluppo di certe regolarità, mentre ne nega altre, proprio come avviene nel "Castello dei destini incrociati" di Italo Calvino, dove il gioco di incroci tra le storie raccontate dai tarocchi permette alcuni sviluppi narrativi e ...

  20. Compliance with an Ordinance Requiring the Use of Personal Flotation Devices by Children in Public Waterways

    Directory of Open Access Journals (Sweden)

    Garen J. Wintemute

    2013-03-01

    Full Text Available Introduction: For children ages 1-14, 21.6% of drowning cases involve swimming, wading, orplaying in natural bodies of water, such as rivers and lakes. Personal flotation devices (PFDs arebelieved to be an effective prevention measure. We measure compliance with city and countyordinances, publicized but not actively enforced, requiring that PFDs be worn by children accessingpublic bodies of water in Sacramento County, California.Methods: During June-August 2010, volunteers conducted 79 observation sessions at threepopular local river beaches where PFDs were available for use at no cost. They recorded personalcharacteristics and PFD use for 1,727 children in or very near the water and believed to be 0-13years of age (the age covered by the ordinances. We used logistic regression to quantify differencesin use by subject characteristics and study site.Results: The prevalence of PFD use was 29.9% overall, with large and significant differencesby age: < 1, 55.6%; 1-4, 37.6%; 5-10, 29.4%; 10-13, 14.6%; P < 0.0001. Usage did not varysignificantly by sex or race/ethnicity, and was somewhat higher at one study site (33.1% than at theothers (25.9% and 27.3%, P = 0.009.Conclusion: The combination of a statutory requirement and a cost-elimination strategy wasassociated with moderate rates of PFD use that were highest among young children.

  1. Lagrange Discrete Ordinates: a new angular discretization for the three dimensional linear Boltzmann equation

    CERN Document Server

    Ahrens, Cory D

    2014-01-01

    The classical $S_n$ equations of Carlson and Lee have been a mainstay in multi-dimensional radiation transport calculations. In this paper, an alternative to the $S_n$ equations, the "Lagrange Discrete Ordinate" (LDO) equations are derived. These equations are based on an interpolatory framework for functions on the unit sphere in three dimensions. While the LDO equations retain the formal structure of the classical $S_n$ equations, they have a number of important differences. The LDO equations naturally allow the angular flux to be evaluated in directions other than those found in the quadrature set. To calculate the scattering source in the LDO equations, no spherical harmonic moments are needed--only values of the angular flux. Moreover, the LDO scattering source preserves the eigenstructure of the continuous scattering operator. The formal similarity of the LDO equations with the $S_n$ equations should allow easy modification of mature 3D $S_n$ codes such as PARTISN or PENTRAN to solve the LDO equations. ...

  2. The TORT three-dimensional discrete ordinates neutron/photon transport code (TORT version 3)

    Energy Technology Data Exchange (ETDEWEB)

    Rhoades, W.A.; Simpson, D.B.

    1997-10-01

    TORT calculates the flux or fluence of neutrons and/or photons throughout three-dimensional systems due to particles incident upon the system`s external boundaries, due to fixed internal sources, or due to sources generated by interaction with the system materials. The transport process is represented by the Boltzman transport equation. The method of discrete ordinates is used to treat the directional variable, and a multigroup formulation treats the energy dependence. Anisotropic scattering is treated using a Legendre expansion. Various methods are used to treat spatial dependence, including nodal and characteristic procedures that have been especially adapted to resist numerical distortion. A method of body overlay assists in material zone specification, or the specification can be generated by an external code supplied by the user. Several special features are designed to concentrate machine resources where they are most needed. The directional quadrature and Legendre expansion can vary with energy group. A discontinuous mesh capability has been shown to reduce the size of large problems by a factor of roughly three in some cases. The emphasis in this code is a robust, adaptable application of time-tested methods, together with a few well-tested extensions.

  3. Wormhole Detection Based on Ordinal MDS Using RTT in Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Saswati Mukherjee

    2016-01-01

    Full Text Available In wireless communication, wormhole attack is a crucial threat that deteriorates the normal functionality of the network. Invasion of wormholes destroys the network topology completely. However, most of the existing solutions require special hardware or synchronized clock or long processing time to defend against long path wormhole attacks. In this work, we propose a wormhole detection method using range-based topology comparison that exploits the local neighbourhood subgraph. The Round Trip Time (RTT for each node pair is gathered to generate neighbour information. Then, the network is reconstructed by ordinal Multidimensional Scaling (MDS followed by a suspicion phase that enlists the suspected wormholes based on the spatial reconstruction. Iterative computation of MDS helps to visualize the topology changes and can localize the potential wormholes. Finally, a verification phase is used to remove falsely accused nodes and identify real adversaries. The novelty of our algorithm is that it can detect both short path and long path wormhole links. Extensive simulations are executed to demonstrate the efficacy of our approach compared to existing ones.

  4. Specular reflection treatment for the 3D radiative transfer equation solved with the discrete ordinates method

    Science.gov (United States)

    Le Hardy, D.; Favennec, Y.; Rousseau, B.; Hecht, F.

    2017-04-01

    The contribution of this paper relies in the development of numerical algorithms for the mathematical treatment of specular reflection on borders when dealing with the numerical solution of radiative transfer problems. The radiative transfer equation being integro-differential, the discrete ordinates method allows to write down a set of semi-discrete equations in which weights are to be calculated. The calculation of these weights is well known to be based on either a quadrature or on angular discretization, making the use of such method straightforward for the state equation. Also, the diffuse contribution of reflection on borders is usually well taken into account. However, the calculation of accurate partition ratio coefficients is much more tricky for the specular condition applied on arbitrary geometrical borders. This paper presents algorithms that calculate analytically partition ratio coefficients needed in numerical treatments. The developed algorithms, combined with a decentered finite element scheme, are validated with the help of comparisons with analytical solutions before being applied on complex geometries.

  5. Optimal Computing Budget Allocation for Ordinal Optimization in Solving Stochastic Job Shop Scheduling Problems

    Directory of Open Access Journals (Sweden)

    Hong-an Yang

    2014-01-01

    Full Text Available We focus on solving Stochastic Job Shop Scheduling Problem (SJSSP with random processing time to minimize the expected sum of earliness and tardiness costs of all jobs. To further enhance the efficiency of the simulation optimization technique of embedding Evolutionary Strategy in Ordinal Optimization (ESOO which is based on Monte Carlo simulation, we embed Optimal Computing Budget Allocation (OCBA technique into the exploration stage of ESOO to optimize the performance evaluation process by controlling the allocation of simulation times. However, while pursuing a good set of schedules, “super individuals,” which can absorb most of the given computation while others hardly get any simulation budget, may emerge according to the allocating equation of OCBA. Consequently, the schedules cannot be evaluated exactly, and thus the probability of correct selection (PCS tends to be low. Therefore, we modify OCBA to balance the computation allocation: (1 set a threshold of simulation times to detect “super individuals” and (2 follow an exclusion mechanism to marginalize them. Finally, the proposed approach is applied to an SJSSP comprising 8 jobs on 8 machines with random processing time in truncated normal, uniform, and exponential distributions, respectively. The results demonstrate that our method outperforms the ESOO method by achieving better solutions.

  6. Time lagged ordinal partition networks for capturing dynamics of continuous dynamical systems

    Energy Technology Data Exchange (ETDEWEB)

    McCullough, Michael; Iu, Herbert Ho-Ching [School of Electrical and Electronic Engineering, The University of Western Australia, Crawley WA 6009 (Australia); Small, Michael; Stemler, Thomas [School of Mathematics and Statistics, The University of Western Australia, Crawley WA 6009 (Australia)

    2015-05-15

    We investigate a generalised version of the recently proposed ordinal partition time series to network transformation algorithm. First, we introduce a fixed time lag for the elements of each partition that is selected using techniques from traditional time delay embedding. The resulting partitions define regions in the embedding phase space that are mapped to nodes in the network space. Edges are allocated between nodes based on temporal succession thus creating a Markov chain representation of the time series. We then apply this new transformation algorithm to time series generated by the Rössler system and find that periodic dynamics translate to ring structures whereas chaotic time series translate to band or tube-like structures—thereby indicating that our algorithm generates networks whose structure is sensitive to system dynamics. Furthermore, we demonstrate that simple network measures including the mean out degree and variance of out degrees can track changes in the dynamical behaviour in a manner comparable to the largest Lyapunov exponent. We also apply the same analysis to experimental time series generated by a diode resonator circuit and show that the network size, mean shortest path length, and network diameter are highly sensitive to the interior crisis captured in this particular data set.

  7. Developing a Patient Care Co-ordination Centre in Trafford, England: lessons from the International Foundation for Integrated Care (IFIC/Advancing Quality Alliance integrated care fellowship experience

    Directory of Open Access Journals (Sweden)

    Michael Gregory

    2015-05-01

    Full Text Available The NHS and Social Care in England are facing one of the biggest financial challenges for a generation. Commissioners and providers need to work on collaborative schemes to manage the increasing demand on health and social care within a period of financial constraint. Different forms of care co-ordination have been developed at different levels across the world.In the north-west of England, the Trafford health and social care economy have been working through a competitive dialogue process with industry to develop an innovative and dynamic solution to deliver seamless co-ordination for all patients and service users. The strategy is to develop a new Patient Care Co-ordination Centre, which will be responsible for the delivery of co-ordinated, quality care. The Patient Care Co-ordination Centre will work at clinical, service, functional and community levels across multiple providers covering risk stratification, preventative, elective and unscheduled care.I am the clinical lead for the Patient Care Co-ordination Centre and during my year as an Advancing Quality Alliance Integrated Care Fellow, I have had the opportunity to study examples of care coordination from UK and international sites. The learning from these visits has been assimilated into the design process of the Patient Care Co-ordination Centre.

  8. Developing a Patient Care Co-ordination Centre in Trafford, England: lessons from the International Foundation for Integrated Care (IFIC/Advancing Quality Alliance integrated care fellowship experience

    Directory of Open Access Journals (Sweden)

    Michael Gregory

    2015-05-01

    Full Text Available The NHS and Social Care in England are facing one of the biggest financial challenges for a generation. Commissioners and providers need to work on collaborative schemes to manage the increasing demand on health and social care within a period of financial constraint. Different forms of care co-ordination have been developed at different levels across the world. In the north-west of England, the Trafford health and social care economy have been working through a competitive dialogue process with industry to develop an innovative and dynamic solution to deliver seamless co-ordination for all patients and service users. The strategy is to develop a new Patient Care Co-ordination Centre, which will be responsible for the delivery of co-ordinated, quality care. The Patient Care Co-ordination Centre will work at clinical, service, functional and community levels across multiple providers covering risk stratification, preventative, elective and unscheduled care. I am the clinical lead for the Patient Care Co-ordination Centre and during my year as an Advancing Quality Alliance Integrated Care Fellow, I have had the opportunity to study examples of care coordination from UK and international sites. The learning from these visits has been assimilated into the design process of the Patient Care Co-ordination Centre.

  9. Added resolution among ordinal level relationships of tapeworms (Platyhelminthes: Cestoda) with complete small and large subunit nuclear ribosomal RNA genes.

    Science.gov (United States)

    Waeschenbach, Andrea; Webster, Bonnie L; Bray, Rodney A; Littlewood, D T J

    2007-10-01

    The addition of large subunit ribosomal DNA (lsrDNA) to small subunit ribosomal DNA (ssrDNA) has been shown to add resolution to phylogenies at various taxonomic levels for a diversity of phyla. We added nearly complete lsrDNA (4057-4593bp) sequences to ssrDNA (1940-2228bp) for 26 ingroup and 3 outgroup taxa in an attempt to provide an improved ordinal phylogeny for the Cestoda. Ten lsrDNA and seven ssrDNA sequences were generated from new taxa and 13 existing partial lsrDNA sequences were sequenced to completion. The majority of phylogenetic signal in the combined analysis came from lsrDNA (69.6% of parsimonious informative sites, as opposed to 30.4% obtained from ssrDNA), resulting in almost identical topologies for lsrDNA and lsr+ssrDNA (pairwise symmetric distance=6) in model-based analyses. Topology testing found trees based on partial lsrDNA (domains D1-D3)+ssrDNA and complete lsr+ssrDNA to differ significantly; the addition of lsrDNA domains D4-D12 had a significant effect on topology. Overall nodal support was greatest in the combined analysis and weakest for ssrDNA only. Our molecular phylogenies differed significantly from those based on morphology alone. Acetabulate lineages form a monophyletic group, with the Tetraphyllidea being paraphyletic. Support for the combined data was high for the following topology: (Litobothriidea (Lecanicephalidea (Rhinebothrium/Rhodobothrium (Clistobothrium (Pachybothrium(Acanthobothrium Proteocephalidea) (Mesocestoididae, Nippotaeniidea, Cyclophyllidea, Tetrabothriidea)))))); all genus names refer to tetraphyllidean lineages. Although the interrelationships among the four most derived taxa remain uncertain, overall ambiguity of the acetabulate interrelationships was reduced. The Pseudophyllidea were recovered as polyphyletic, with support for a sister-group relationship between Diphyllobothriidae and Haplobothriidea. The monophyly of the Trypanorhyncha was recovered for the first time based on molecular data. The positions

  10. GLOBALIZATION AND BUILDING OF IDENTITIES IN MODERN CITIES: A DISCOURSE ANALYSIS AT BARCELONA’S NEW CIVIC ORDINANCE

    Directory of Open Access Journals (Sweden)

    LILIANA VARGAS MONROY

    2007-11-01

    Full Text Available This paper makes a discourse analysis of the Civic Ordinance of Barcelona, adopted by the City Hall of Barcelona-Spain in January of 2006, in order to typify and manage behaviour in the public spaces of the city. The textual corpuswe used for this analysis is the Ordinance project in its two versions. The Discourse Analysis methodology used in thisstudy has been proposed by different authors in this field (Martín Rojo, 2001; Parker, 1992; Potter & Wetherell, 1987;Van Dijk, 2003; Wetherell, 2001. Results point to the emergence of two kinds of discourses inside the text, as well as the strategies from which both discourses allow the construction of citizens’ identities as a new way of governability in the spaces of contemporary European cities.

  11. How can the co-ordinate transformation method of beam matching be extended to include separately labelled collimators?

    Science.gov (United States)

    Morgan-Fletcher, S; McKenzie, A L

    1996-03-01

    The problem of matching radiation beams was tackled by Siddon in 1980 using co-ordinate transformations. Since then, the need to distinguish between individual collimators in prescriptions of treatment set-up, brought about by the widespread use of 3-D treatment planning systems and asymmetric fields, as well as a reversal of the rotation sense in the turntable co-ordinate system proposed by the International Electrotechnical Commission, have made it necessary to revisit this particular problem. This paper builds upon Siddon's general equations for the particular case of matching beams, and derives expressions for calculating treatment-unit settings which may be used in a computer program without the need to perform matrix manipulation. The expression treat the individual collimator jaws separately.

  12. Co-ordination of a new bis-terpyridine ligand with cupric perchlorate yielding a dinuclear M 2L species

    Science.gov (United States)

    Knight, James C.; Prabaharan, Ravi; Edwards, Peter G.; Amoroso, Angelo J.

    2011-03-01

    We report the synthesis of a new bis-terpyridine ligand which could potentially yield a variety of polynuclear complexes. An investigation of the co-ordination chemistry of this ligand with Cu(II) ions in a 1:1 ratio yielded a complex with a 2:1 ratio of Cu to ligand. The crystal structure of the dinuclear copper(II) complex shows the two equivalent copper cations are co-ordinated via five donor atoms in a highly distorted square pyramidal arrangement. The structure was solved in a monoclinic space group C2/c with cell parameters, a = 21.340(5), b = 14.004(5), c = 18.368(5) Å, α = 90°, β = 106.575(5)°, γ = 90°, volume = 5261(3) Å 3, Z = 4.

  13. Time-dependent Multi-group Multidimensional Relativistic Radiative Transfer Code Based On Spherical Harmonic Discrete Ordinate Method

    CERN Document Server

    Tominaga, Nozomu; Blinnikov, Sergei I

    2015-01-01

    We develop a time-dependent multi-group multidimensional relativistic radiative transfer code, which is required to numerically investigate radiation from relativistic fluids involved in, e.g., gamma-ray bursts and active galactic nuclei. The code is based on the spherical harmonic discrete ordinate method (SHDOM) that evaluates a source function including anisotropic scattering in spherical harmonics and implicitly solves the static radiative transfer equation with a ray tracing in discrete ordinates. We implement treatments of time dependence, multi-frequency bins, Lorentz transformation, and elastic Thomson and inelastic Compton scattering to the publicly available SHDOM code. Our code adopts a mixed frame approach; the source function is evaluated in the comoving frame whereas the radiative transfer equation is solved in the laboratory frame. This implementation is validated with various test problems and comparisons with results of a relativistic Monte Carlo code. These validations confirm that the code ...

  14. The impacts of pretreatment on the fermentability of pretreated lignocellulosic biomass: a comparative evaluation between ammonia fiber expansion and dilute acid pretreatment

    Directory of Open Access Journals (Sweden)

    Dale Bruce E

    2009-12-01

    Full Text Available Abstract Background Pretreatment chemistry is of central importance due to its impacts on cellulosic biomass processing and biofuels conversion. Ammonia fiber expansion (AFEX and dilute acid are two promising pretreatments using alkaline and acidic pH that have distinctive differences in pretreatment chemistries. Results Comparative evaluation on these two pretreatments reveal that (i AFEX-pretreated corn stover is significantly more fermentable with respect to cell growth and sugar consumption, (ii both pretreatments can achieve more than 80% of total sugar yield in the enzymatic hydrolysis of washed pretreated solids, and (iii while AFEX completely preserves plant carbohydrates, dilute acid pretreatment at 5% solids loading degrades 13% of xylose to byproducts. Conclusion The selection of pretreatment will determine the biomass-processing configuration, requirements for hydrolysate conditioning (if any and fermentation strategy. Through dilute acid pretreatment, the need for hemicellulase in biomass processing is negligible. AFEX-centered cellulosic technology can alleviate fermentation costs through reducing inoculum size and practically eliminating nutrient costs during bioconversion. However, AFEX requires supplemental xylanases as well as cellulase activity. As for long-term sustainability, AFEX has greater potential to diversify products from a cellulosic biorefinery due to lower levels of inhibitor generation and lignin loss.

  15. An analytical representation for the solution of neutron kinetic transport equation in slab-geometry multigroup discrete ordinates formulation

    Energy Technology Data Exchange (ETDEWEB)

    Tomaschewski, Fernanda K.; Segatto, Cynthia F., E-mail: fernandasls_89@hotmail.com, E-mail: cynthia.segatto@ufrgs.br [Universidade Federal do Rio Grande do Sul (UFRS), Porto Alegre, RS (Brazil). Programa de Pos-Graduacao em Matematica Aplicada; Barros, Ricardo C., E-mail: rcbarros@pq.cnpq.br [Universidade do Estado do Rio de Janeiro (UERJ), Nova Friburgo, RJ (Brazil). Departamento de Modelagem Computacional

    2015-07-01

    Presented here is a decomposition method based on series representation of the group angular fluxes and delayed neutron precursors in smoothly continuous functions for energy multigroups, slab-geometry discrete ordinates kinetics equations supplemented with a prescribed number of delayed neutron precursors. Numerical results to a non-reflected sub-critical slab stabilized by steady-state sources are given to illustrate the accuracy and efficiency of the o offered method. (author)

  16. Characteristics of Community Newspaper Coverage of Tobacco Control and Its Relationship to the Passage of Tobacco Ordinances.

    Science.gov (United States)

    Eckler, Petya; Rodgers, Shelly; Everett, Kevin

    2016-10-01

    To answer the call for more systematic surveillance, analysis and evaluation of tobacco news coverage, a 6-year content analysis of newspaper stories from Missouri was conducted to evaluate the presence of public health facts and characteristics of stories framed for or against tobacco control. The method was a content analysis of all Missouri newspapers (N = 381) from September 2006 to November 2011 for a total sample of 4711. Results were connected to the larger, societal context within which newspaper stories reside, i.e., towns that passed or did not pass a smoke-free ordinance during the project intervention. Results showed the majority of news stories were about tobacco control, which were mostly written at the local level, were episodic, and carried a positive slant toward tobacco control. However, there were more negative than positive headlines, and more negative editorials than non-editorials. Tobacco control stories used fewer public health facts than non-tobacco control stories. Towns with existing smoke-free ordinances had more tobacco control stories, and towns without smoke-free ordinances had fewer tobacco control stories and more non-tobacco control stories, suggesting a connection between news media coverage and the passage of smoke-free policies. We conclude that the tobacco industry may have had success in impacting news stories in no-ordinance cities by diverting attention from tobacco control to secondary topics, such as youth smoking, which meant stories had fewer public health facts and fewer positive health benefits in towns that may have needed these details most.

  17. Report of the Regional Co-ordination Meeting for the North Sea and Eastern Arctic (RCM NS&EA) 2014

    OpenAIRE

    Armstrong, M.; van Beek, F; DALSKOV J.; Elliott, M; Elson, J.; Griuniene, V. (Vilda); M. Hansson; Janakakis, M. (Marta); Kjems-Nilsen, H. (Henrik); Knapp, A. (Amelie); Kunzlik, P. (Phil); Lorenzo-González, J. (José); Mahe, K (Kelig); Morgado, C.; Nimmegeers, S.

    2014-01-01

    Report of the Regional Co-ordination Meeting for the North Sea and Eastern Arctic (RCM NS&EA) 2014 Swedish University of Agriculture Sciences (SLU Aqua) Lysekil, Sweden 08-12 September 2014 The RCM NS&EA met in Lysekil (Sweden) between 8-12 September 2014. The main purpose of the RCM is coordinate the National Programmes (NP) of the Member States (MS) in the North Sea region for 2015.

  18. CONSIDERAȚII RELATIVE LA CONCEPTUL DE ORDINE PUBLICĂ ÎN DREPTUL INTERNAȚIONAL PRIVAT

    Directory of Open Access Journals (Sweden)

    Victor VOLCINSCHI

    2017-07-01

    Full Text Available Articolul este consacrat analizei aspectelor definirii conceptului de ordine publică în dreptul internațional, corelației dintre conceptele de ordine publică de drept intern și de drept internațional privat și a funcțiilor sociale pe care le în­dep­linește fiecare din ele. Prin analiza reglementărilor legale, a practicii și a fondului doctrinar din domeniu sunt analizate condițiile invocării excepției de ordine publică în dreptul internațional privat, demonstrându-se în mod separat specificul invocării excepției de ordine publică în procedura de refuz al hotărârilor judecătorești străine și în procedura de refuz al sentințelor arbitrale străine.CONSIDERATIONS REGARDING THE PUBLIC ORDER IN THE INTERNATIONAL PRIVATE LAWDedicated to the analysis of the issues of defining the concept of public order in the international law, the correlation between the concepts of public order of national law and private international law and of the social functions performed by each of them. By analyzing the legal regulations, the practice and the doctrine in the field, are being analyzed the conditions of invocation of public order exception in private international law, and demonstrated separately the specifics of invocation of the public order exception in the procedure of refusal of foreign judgments and in the procedure of refusal of foreign arbitral awards.

  19. La enseñanza del número cardinal y ordinal en educación infantil

    Directory of Open Access Journals (Sweden)

    Laura Collado Arroyo

    2014-12-01

    Full Text Available En el marco de la Teoría de las Situaciones Didácticas, hemos diseñado, implementado y evaluado, en el aula de segundo de Educación Infantil, dos situaciones de enseñanza: el juego del tren y el juego de las invitaciones y los sobres. En ambos casos, la estrategia óptima para resolver la situación es el recuento y la utilización del número natural en su significado ordinal o cardinal, contenidos que queremos trabajar de una manera funcional y significativa, características que están ausentes en las propuestas de las editoriales de los libros de texto que más se utilizan en las aulas, tras haber realizado un análisis de las mismas. The teaching of cardinal and ordinal numbers in Infant Education. Within the framework of Theory of Didactical Situations in Mathematics, we have designed, implemented and assessed two situations for a four year old classroom. These situations were ‘Train Game’ and ‘Invitations and Envelopes Game’. In both cases, counting and the use of natural numbers as ordinals or cardinals is the ideal strategy in order to solve the situation. These are the contents which we want the students to work in a functional and meaningful way due to these characteristics don’t exist in the proposals of textbooks publishers which prevail in most classrooms.

  20. The co-ordination of a RTD project at European level: difficulties and traps by the different steps.

    Science.gov (United States)

    Doddoli, Roberto

    2002-08-01

    When a scientist wants to set up and co-ordinate a Research and Technical Development (RTD) project for the first time, he is confronted with a certain number of factors, which, generally, are completely unknown. To co-ordinate a research project, it is not sufficient to have, as starting point, a set of interesting and innovative scientific themes. In fact, after the first preparatory steps, he is confronted with a number of difficulties such as the sinking of the project before it is put forward for financing. The different visions from the scientific and industrial partners are sometimes completely opposite (4): so it is necessary to understand and to assess the requirements of every participant. The industrial partner approach is, for example, linked to this assessment, bearing in mind that his involvement is indispensable for the viability of the project. First of all, this work aims to warn scientists who wish to start up in such an adventure, and secondly serve as a 'vademecum for the co-ordinator' in order to achieve successful completion of work that requires big investments in energy and time.

  1. Co-ordinated synthesis of phytoalexin biosynthetic enzymes in biologically-stressed cells of bean (Phaseolus vulgaris L.).

    Science.gov (United States)

    Cramer, C L; Bell, J N; Ryder, T B; Bailey, J A; Schuch, W; Bolwell, G P; Robbins, M P; Dixon, R A; Lamb, C J

    1985-02-01

    Changes in the rates of synthesis of three enzymes of phenyl-propanoid biosynthesis in Phaseolus vulgaris L. (dwarf French bean) have been investigated by immunoprecipitation of [S]methionine-labeled enzyme subunits with mono-specific antisera. Elicitor causes marked, rapid but transient co-ordinated increases in the rate of synthesis of phenyl-alanine ammonia-lyase, chalcone synthase and chalcone isomerase concomitant with the phase of rapid increase in enzyme activity at the onset of accumulation of phenyl-propanoid-derived phytoalexin antibiotics in suspension cultures of P. vulgaris. Co-ordinate induction of enzyme synthesis is also observed in hypocotyl tissue during race:cultivar-specific interactions with Colletotrichum lindemuthianum, causal agent of anthracnose. In an incompatible interaction (host resistant) there are early increases apparently localized to the initial site of infection prior to the onset of phytoalexin accumulation and expression of hypersensitive resistance. In contrast, in a compatible interaction (host susceptible) there is no induction of synthesis in the early stages of infection, but a delayed widespread response at the onset of lesion formation associated with attempted lesion limitation. It is concluded that expression of the phytoalexin defense response in biologically stressed cells of P. vulgaris characteristically involves co-ordinate induction of synthesis of phytoalexin biosynthetic enzymes.

  2. Comparative techno-economic analysis of steam explosion, dilute sulfuric acid, ammonia fiber explosion and biological pretreatments of corn stover.

    Science.gov (United States)

    Baral, Nawa Raj; Shah, Ajay

    2017-05-01

    Pretreatment is required to destroy recalcitrant structure of lignocelluloses and then transform into fermentable sugars. This study assessed techno-economics of steam explosion, dilute sulfuric acid, ammonia fiber explosion and biological pretreatments, and identified bottlenecks and operational targets for process improvement. Techno-economic models of these pretreatment processes for a cellulosic biorefinery of 113.5 million liters butanol per year excluding fermentation and wastewater treatment sections were developed using a modelling software-SuperPro Designer. Experimental data of the selected pretreatment processes based on corn stover were gathered from recent publications, and used for this analysis. Estimated sugar production costs ($/kg) via steam explosion, dilute sulfuric acid, ammonia fiber explosion and biological methods were 0.43, 0.42, 0.65 and 1.41, respectively. The results suggest steam explosion and sulfuric acid pretreatment methods might be good alternatives at present state of technology and other pretreatment methods require research and development efforts to be competitive with these pretreatment methods. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Rapid near infrared spectroscopy for prediction of enzymatic hydrolysis of corn bran after various pretreatments

    DEFF Research Database (Denmark)

    Baum, Andreas; Agger, Jane; Meyer, Anne S.

    2012-01-01

    step is to increase the responsivity of the substrate to enzymatic attack and the type of pretreatment affects the enzymatic conversion efficiency. Destarched corn bran is a fibrous, heteroxylan-rich side-stream from the starch industry which may be used as a feedstock for bioethanol production...... or as a source of xylose for other purposes. In the present study we demonstrate the use of diffuse reflectance near infrared spectroscopy (NIR) as a rapid and non-destructive analytical tool for evaluation of pretreatment effects on destarched corn bran. NIR was used to achieve classification between 43...... differently pretreated corn bran samples using principal component analysis (PCA) and hierarchal clustering algorithms. Quantification of the enzymatically released monosaccharides by HPLC was used to design multivariate calibration models (biPLS) on the NIR spectra. The models could predict the enzymatic...

  4. Effect of thermal pretreatment on equilibrium moisture content of lignocellulosic biomass.

    Science.gov (United States)

    Acharjee, Tapas C; Coronella, Charles J; Vasquez, Victor R

    2011-04-01

    The equilibrium moisture content (EMC) of raw lignocellulosic biomass, along with four samples subjected to thermal pretreatment, was measured at relative humidities ranging from 11% to 97% at a constant temperature of 30 °C. Three samples were prepared by treatment in hot compressed water by a process known as wet torrefaction, at temperatures of 200, 230, and 260 °C. An additional sample was prepared by dry torrefaction at 300 °C. Pretreated biomass shows EMC below that of raw biomass. This indicates that pretreated biomass, both dry and wet torrefied, is more hydrophobic than raw biomass. The EMC results were correlated with a recent model that takes into account additional non-adsorption interactions of water, such as mixing and swelling. The model offers physical insight into the water activity in lignocellulosic biomass.

  5. Heat-pretreatment and enzymolysis behavior of the lotus seed protein.

    Science.gov (United States)

    Pan, A-Dan; Zeng, Hong-Yan; Alain, Gohi Bi Foua Claude; Feng, Bo

    2016-06-15

    Lotus seed protein (LSP) was heat-pretreated before enzymolysis in order to seek a greater degree of hydrolysis (DH) during enzymatic hydrolysis. The parameters including substrate concentration, temperature, pH, and papain concentration were optimized by response surface methodology in the enzymolysis of the heat-pretreated LSP. The influence of substrate concentration on the non-pretreated LSP enzymolysis was assessed, and the enzymolysis was found to obey the Haldane model with inhibition by LSP substrate. The initial concentration of non-pretreated LSP was inferred theoretically to be 11.07 g/L in order to avoid substrate inhibition. On the other hand, Chrastil model was fitted and the diffusion resistance constant values were in the range of 0.5-0.6 for the diffusion-controlled encounter of enzyme and substrate, implying that diffusion was a rate-limiting step. The heat-pretreatment at 60 °C for 60 min could increase the DH of the LSP, which enhanced the efficiency of the enzymolysis by papain.

  6. Evaluating the impact of ammonia fiber expansion (AFEX) pretreatment conditions on the cost of ethanol production.

    Science.gov (United States)

    Bals, Bryan; Wedding, Chris; Balan, Venkatesh; Sendich, Elizabeth; Dale, Bruce

    2011-01-01

    Ammonia fiber expansion (AFEX) pretreatment is an ammonia-based process for improving the susceptibility of lignocellulosic biomass to enzymatic attack. Four parameters--ammonia loading, water loading, reaction temperature, and residence time--can be varied in order to optimize AFEX pretreatment. The effect of these parameters on process economics of ethanol production was studied using a leading biorefinery model. Ammonia loading and residence time had the greatest impact on the economics of ethanol production, primarily due to processing costs for the chilled water condenser and the capital cost of the AFEX reactor. Water loading and reaction temperature had only modest impact on process economics. In addition, the impact of pretreatment conditions on makeup ammonia requirements was explored experimentally, which ranged from 15 to 25 g ammonia/kg biomass. Overall, pretreatment conditions can change the costs of ethanol production by up to 35 cents per gallon ethanol in an 850 ton/day refinery. By linking the results obtained from this Aspen model to experimental results for ethanol production and makeup ammonia recovery, this study can be used to create an economic optimum for AFEX pretreatment in contrast with simply maximizing fermentable sugar production. Copyright © 2010 Elsevier Ltd. All rights reserved.

  7. Key factors governing alkaline pretreatment of waste activated sludge

    Institute of Scientific and Technical Information of China (English)

    Xianli Shi; Li Deng; Fangfang Sun; Jieyu Liang; Xu Deng

    2015-01-01

    Alkaline pretreatment is an effective technology to disintegrate sewage sludge, where alkali dosage and sludge concentration are two important factors. pH value or alkali concentration is usually adjusted in order to deter-mine a proper dosage of alkali. Our work has found that this is not a good strategy. A new parameter, the ratio of alkali to sludge (Ra/s), is more sensitive in controlling the alkali dosage. The sludge concentration Cs and reten-tion time t are two other important factors to consider. The validity of these arguments is confirmed with model-ing and experiments. The individual effect of Ra/s, Cs and t was studied separately. Then the combined effect of these three factors was evaluated. The sludge disintegration degree of 44.7%was achieved with the optimized factors. Furthermore, an alkaline-microwave combined pretreatment process was carried out under these optimized conditions. A high disintegration degree of 62.3%was achieved while the energy consumption of microwave was much lower than previously reported.

  8. Biological pretreatment of Yellow River water

    Institute of Scientific and Technical Information of China (English)

    XIE Shu-guang; TANG Xiao-yan; WU Wei-zhong; WEN Dong-hui; WANG Zhan-sheng

    2005-01-01

    Bio-ceramic filter(BF) and moving-bed biofilm reactor(MBBR) were used for biological pretreatment of Yellow River water in this study. The BF only had slight advantage over MBBR for TOC and ammonia removal. However, like UV254, the average removal rate of THMFP in the BF was much higher than that in the MBBR. UV254 removal did not show obvious correlation with trihalomethane formation potential(THMFP) removal. Hexachlorocyclohexane could be effectively removed in both BF and MBBR. As for diatom and cyanobateria removal the MBBR had better performance than the BF, which was contrary to the average chlorophyll-a (Chi-a) removal rate. The proposal was made in this study that biological flocculation and sedimentation of sloughed biofilm should play a more important role on algae removal in the MBBR than in the BF. The BF and MBBR could effectively remove microcystins. Moreover, MBBR could be a promising technology for biological pretreatment.

  9. Radiation pretreatment of cellulose for energy production

    Science.gov (United States)

    Dela Rosa, A. M.; Dela Mines, A. S.; Banzon, R. B.; Simbul-Nuguid, Z. F.

    The effect of radiation pretreatment of agricultural cellulosic wastes was investigated through hydrolytic reactions of cellulose. Gamma irradiation significantly increased the acid hydrolysis of rice straw, rice hull and corn husk. The yields of reducing sugar were higher with increasing radiation dose in these materials. The observed radiation effect varied with the cellulosic material but it correlated with neither the cellulose content nor the lignin content. Likewise, the radiation pretreatment accelerated the subsequent enzymatic hydrolysis of rice straw and rice hull by cellulase. The irradiated rice straw appeared to be a better growth medium for the cellulolytic microorganism, Myrothecium verrucaria, than the non-irradiated material. This was attributed to increased digestibility of the cellulose by the microorganism.

  10. Pretreatment of Dioscorea zingiberensis for Microbial Transformation

    Directory of Open Access Journals (Sweden)

    Tianxiang Zheng

    2014-09-01

    Full Text Available The influences of five pretreatments on fungal growth and enzyme production during microbial transformation of Dioscorea zingiberensis (DZW were studied. The biomass, α-rhamnase and β-glucosidase activities in the fermentation system were employed in the study to determine how each method affected the efficiency of microbial transformation. The fungal strain grew better on the substrate which contained easily utilized carbon source. While lack of carbon source induced the strain produce more glucosidase. Among five pretreatment methods, complex enzymatic hydrolyzation can remove 84.3% starch and 76.5% fibre from DZW in form of sugar, which resulted in high α-rhamnase activity of 2.89 IU/mL and β-glucosidase activity of 8.17 IU/mL in fermentation broth.

  11. Pretreatment of Latent Prints for Laser Development.

    Science.gov (United States)

    Menzel, E R

    1989-06-01

    The pretreatment procedures for laser detection of latent fingerprints is reviewed. The general features of laser detection and the operational aspects of the examination of physical evidence for laser fingerprint detection are enumerated in the initial sections. The literature review is divided into various pretreatment approaches. Cited studies prior to 1981 are primarily concerned with the demonstration of the viability of laser fingerprint detection, whereas work post-1981 addresses issues of compatibility with the traditional methods of fingerprint development, examination of difficult surfaces, and the routine implementation of laser detection by law enforcement agencies. Related topics of research, review articles, conference reports, case examinations, the research support climate, and future trends are also briefly addressed.

  12. DiagTest3Grp: An R Package for Analyzing Diagnostic Tests with Three Ordinal Groups

    Directory of Open Access Journals (Sweden)

    Jingqin Luo

    2012-10-01

    Full Text Available Medical researchers endeavor to identify potentially useful biomarkers to develop marker-based screening assays for disease diagnosis and prevention. Useful summary measures which properly evaluate the discriminative ability of diagnostic markers are critical for this purpose. Literature and existing software, for example, R packages nicely cover summary measures for diagnostic markers used for the binary case (e.g., healthy vs. diseased. An intermediate population at an early disease stage usually exists between the healthy and the fully diseased population in many disease processes. Supporting utilities for three-group diagnostic tests are highly desired and important for identifying patients at the early disease stage for timely treatments. However, application packages which provide summary measures for three ordinal groups are currently lacking. This paper focuses on two summary measures of diagnostic accuracy—volume under the receiver operating characteristic surface and the extended Youden index, with three diagnostic groups. We provide the R package DiagTest3Grp to estimate, under both parametric and nonparametric assumptions, the two summary measures and the associated variances, as well as the optimal cut-points for disease diagnosis. An omnibus test for multiple markers and a Wald test for two markers, on independent or paired samples, are incorporated to compare diagnostic accuracy across biomarkers. Sample size calculation under the normality assumption can be performed in the R package to design future diagnostic studies. A real world application evaluating the diagnostic accuracy of neuropsychological markers for Alzheimer’s disease is used to guide readers through step-by-step implementation of DiagTest3Grp to demonstrate its utility.

  13. Waste Separations and Pretreatment Workshop report

    Energy Technology Data Exchange (ETDEWEB)

    Cruse, J.M. [Westinghouse Hanford Co., Richland, WA (United States); Harrington, R.A. [Kaiser Engineers Hanford Co., Richland, WA (United States); Quadrel, M.J. [Battelle Pacific Northwest Lab., Richland, WA (United States)

    1994-01-01

    This document provides the minutes from the Waste Separations and Pretreatment Workshop sponsored by the Underground Storage Tank-Integrated Demonstration in Salt Lake City, Utah, February 3--5, 1993. The Efficient Separations and Processing-Integrated Program and the Hanford Site Tank Waste Remediation System were joint participants. This document provides the detailed minutes, including responses to questions asked, an attendance list, reproductions of the workshop presentations, and a revised chart showing technology development activities.

  14. I concetti di "materia", "forma" e "ordine" nel pensiero teorico musicale medievale e contemporaneo

    Directory of Open Access Journals (Sweden)

    Cecilia Panti

    2011-01-01

    Full Text Available La dimensione teorica della musica occidentale, nella sua evoluzione storica, ha inevitabilmente fatto uso di concetti essenziali alla definizione di come il suono è musicalmente organizzato o organizzabile. Fra questi, risultano imprescindibili le nozioni di materia, forma e ordine, che implicano rispettivamente, nei pur diversi ambiti linguistici e contesti storico-filosofici di riferimento, ciò di cui è fatta la musica, ciò a cui la materia sonora tende, e come tale tensione è realizzata. Scopo di questo contributo è una valutazione d’insieme sulla valenza filosofica e l’uso di tali concetti nel pensiero musicale occidentale altomedievale e in quello del Novecento, che nonostante la distanza cronologica presentano convergenze significative. Nel Medioevo, un lungo processo di elaborazione teorico-pratica permise la matematizzazione dello spazio (e, più tardi, anche del tempo musicale, attraverso l’adattamento di moduli melodici, trasmessi oralmente, alle strutture scalari desunte dalla teoria greco-boeziana. La forma e l’ordo musicali furono quindi riferiti ai criteri fisico-matematici atti a distinguere nella materia sonora, in sé disorganica e indefinita, ciò che è musicale da ciò che non lo è. Tale concezione sparisce con l’affermarsi del sistema tonale, ove il suono fisico è concepito come “pre-formato” e “pre-ordinato” nella gamma scalare e nei vincoli attrattivi “naturali” degli armonici. In conseguenza, i concetti di forma e ordine abbandonano il contesto acustico, andando a definire i criteri teorici della composizione artistica, in linea con l’idea filosofica del loro esprimere la coerenza logico-sintattica dell’“insieme organico” (la Formenlehre teorizzata da Widmann. Nell’ambito del pensiero musicale del Novecento, la crisi del sistema tonale e la messa a punto di nuove modalità e tecniche di produzione del suono hanno riorientato la valenza significante e l’uso di questi tre concetti

  15. Importance of food waste pre-treatment efficiency for global warming potential in life cycle assessment of anaerobic digestion systems

    DEFF Research Database (Denmark)

    Carlsson, My; Naroznova, Irina; Møller, Jacob

    2015-01-01

    A need for improvement of food waste (FIAT) pre-treatment methods has been recognized, but few life cycle assessments (LCA) of FIN management systems have considered the pre-treatment with respect to input energy, loss of organic material and nutrients for anaerobic digestion (AD) and/or further...... treatment of the refuse. The objective of this study was to investigate how FW pre-treatment efficiency impacts the environmental performance of waste management, with respect to global warming potential (GWP). The modeling tool EASETECH was used to perform consequential LCA focusing on the impact...

  16. Fuel ethanol production from corn stover under optimized dilute phosphoric acid pretreatment and enzymatic hydrolysis

    Science.gov (United States)

    Ethanol is a renewable oxygenated fuel. Dilute acid pretreatment is a promising pretreatment technology for conversion of lignocellulosic biomass to fuel ethanol. Generation of fermentable sugars from corn stover involves pretreatment and enzymatic saccharification. Pretreatment is crucial as nat...

  17. Optimizing cellulase usage for improved mixing and rheological properties of acid-pretreated sugarcane bagasse.

    Science.gov (United States)

    Geddes, Claudia C; Peterson, James J; Mullinnix, Michael T; Svoronos, Spyros A; Shanmugam, K T; Ingram, Lonnie O

    2010-12-01

    Consolidation of bioprocessing steps with lignocellulose is limited by hydrolysate toxicity, the fibrous nature of suspensions, and low activity of cellulase enzymes. Combinations of enzyme dose and treatment conditions improved the flow properties and pumping of acid-pretreated sugarcane bagasse slurries (10% dry weight). Low levels of cellulase enzyme (0.1 and 0.5 FPU/g dry weight acid-pretreated bagasse) were found to reduce viscosities by 77-95% after 6 h, solubilizing 3.5% of the bagasse dry weight. Flow of slurries through small funnels was a useful predictor of success with centrifugal and diaphragm pumps. Equations were derived that describe viscosity and solubilized carbohydrates as a function of time and cellulase dosage. Blending of acid-pretreated bagasse (10% dry weight) with suspensions of acid-pretreated bagasse (10% dry weight) that had been previously digested with cellulase enzymes (low viscosity) did not increase viscosity in a linear fashion. Viscosity of these mixtures remained relatively constant until a threshold level of new fiber was reached, followed by a rapid increase with further additions. Up to 35% fresh acid-pretreated bagasse could be blended with enzyme-digested fiber (5.0 FPU/g dry weight acid-pretreated fiber; 6 h) with only a modest increase in viscosity. The smooth surfaces of enzyme-treated fiber are proposed to hinder the frequency and extent of interactions between fibrils of fresh fiber particles (acid-pretreated) until a threshold concentration is achieved, after which fiber interactions and viscosity increase dramatically. These results were used to model the viscosity in an ideal continuous stirred tank reactor (liquefaction) as a function of residence time and enzyme dosage.

  18. A novel free ammonia based pretreatment technology to enhance anaerobic methane production from primary sludge.

    Science.gov (United States)

    Wei, Wei; Zhou, Xu; Xie, Guo-Jun; Duan, Haoran; Wang, Qilin

    2017-10-01

    This study proposed a novel free ammonia (FA, i.e., NH3 ) pretreatment technology to enhance anaerobic methane production from primary sludge for the first time. The solubilization of primary sludge was substantially enhanced following 24 h FA pretreatment (250-680 mg NH3 -N/L), by which the release of soluble chemical oxygen demand (SCOD) (i.e., 0.4 mg SCOD/mg VS added; VS: volatile solids) was approximately 10 times as much as that without pretreatment (i.e., 0.03 mg SCOD/mg VS added). Then, biochemical methane potential (BMP) tests demonstrated that FA pretreatment of 250-680 mg NH3 -N/L was capable of enhancing anaerobic methane production while the digestion time was more than 7 days. Model based analysis indicated that the improved anaerobic methane production was due to an increased biochemical methane potential (B0 ) of 8-17% (i.e., from 331 to 357-387 L CH4 /kg VS added), with the highest B0 achieved at 420 mg NH3 -N/L pretreatment. However, FA pretreatment of 250-680 mg NH3 -N/L decreased hydrolysis rate (k) by 24-38% compared with control (i.e., from 0.29 d(-1) to 0.18-0.22 d(-1) ), which explained the lower methane production over the first 7 days' digestion period. Economic analysis and environmental evaluation demonstrated that FA pretreatment technology was environmentally friendly and economically favorable. Biotechnol. Bioeng. 2017;114: 2245-2252. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  19. Evaluation of high solids alkaline pretreatment of rice straw.

    Science.gov (United States)

    Cheng, Yu-Shen; Zheng, Yi; Yu, Chao Wei; Dooley, Todd M; Jenkins, Bryan M; VanderGheynst, Jean S

    2010-11-01

    Fresh-harvested, air-dried rice straw was pretreated at a water content of 5 g H(2)O/g straw using sodium hydroxide (NaOH) and compared to pretreatment at 10 g H(2)O/g straw by hydrated lime (Ca(OH)(2)). Full factorial experiments including parallel wash-only treatments were completed with both sources of alkali. The experiments were designed to measure the effects of alkaline loading and pretreatment time on delignification and sugar yield upon enzymatic hydrolysis. Reaction temperature was held constant at 95 degrees C for lime pretreatment and 55 degrees C for NaOH pretreatment. The range of delignification was 13.1% to 27.0% for lime pretreatments and was 8.6% to 23.1% for NaOH pretreatments. Both alkaline loading and reaction time had significant positive effects (p pretreatment at 95 degrees C, but there was little effect observed at 55 degrees C. Post-pretreatment washing of biomass was not necessary for subsequent enzymatic hydrolysis. Maximum glucose yields were 176.3 mg/g dried biomass (48.5% conversion efficiency of total glucose) in lime-pretreated and unwashed biomass and were 142.3 mg/g dried biomass (39.2% conversion efficiency of total glucose) in NaOH-pretreated and unwashed biomass.

  20. Prognotic significance of pretreatment proliferative activity in adult acute leukemia.

    Science.gov (United States)

    Hart, J S; George, S L; Frei, E; Bodey, G P; Nickerson, R C; Freireich, E J

    1977-04-01

    A statistical analysis of the prognostic significance of eight pretreatment variables was undertaken for 71 previously untreated adult patients with acute leukemia seen at M.D. Anderson Hospital over a 5 1/2-year period. None of the patients had received any prior therapy. Nearly all of the patients (68 of the 71) were treated with 4- or 5-day courses of arabinosyl-cytosine alone or in combination with cyclophosphamide, vincristine (oncovin) and prednisone (COAP). The pretreatment variables studied were age at diagnosis, the percent labeling index of the bone marrow leukemic cells, diagnosis, the highest temperature prior to start of treatment, the marrow clot section cellularity and smear differential percent of blasts, percent absolute marrow leukemic cell infiltrate and absolute number of blasts X 10(3)/mm3 in the peripheral blood. Fifty-one patients had acute myeloblastic leukemia (AML) and 20 patients had acute lymphoblastic leukemia (ALL). Using a statistical regression model approach, the only variables found to be of significant prognostic importance with respect to the probability of complete remission for AML patients were the pretreatment percent labeling index, the age of the patient and the highest temperature prior to start of treatment. Unlike AML, the initial percent labeling index did not appear to be of prognostic significance for ALL patients. AML patients with high labeling indices (larger than or equal to 9%) and young patients in general (especially those less than 40 years old) had the best remission rates. With respect to the length of complete remission and survival for all patients, the only important variables were the pretreatment percent labeling index and the age of the patient, respectively. Once in complete remission, an initially high labeling index was an unfavorable sign with respect to length of remission, regardless of the patient's diagnosis. The results of this study are supportive of studies in experimental systems