Current-voltage relation for thin tunnel barriers: Parabolic barrier model
Hansen, Kim; Brandbyge, Mads
2004-01-01
We derive a simple analytic result for the current-voltage curve for tunneling of electrons through a thin uniform insulating layer modeled by a parabolic barrier. Our model, which goes beyond the Wentzel–Kramers–Brillouin approximation, is applicable also in the limit of highly transparant barri...
Graphene Nanoribbon Conductance Model in Parabolic Band Structure
Mohammad Taghi Ahmadi
2010-01-01
Full Text Available Many experimental measurements have been done on GNR conductance. In this paper, analytical model of GNR conductance is presented. Moreover, comparison with published data which illustrates good agreement between them is studied. Conductance of GNR as a one-dimensional device channel with parabolic band structures near the charge neutrality point is improved. Based on quantum confinement effect, the conductance of GNR in parabolic part of the band structure, also the temperature-dependent conductance which displays minimum conductance near the charge neutrality point are calculated. Graphene nanoribbon (GNR with parabolic band structure near the minimum band energy terminates Fermi-Dirac integral base method on band structure study. While band structure is parabola, semiconducting GNRs conductance is a function of Fermi-Dirac integral which is based on Maxwell approximation in nondegenerate limit especially for a long channel.
Nonlinear Hyperbolic-Parabolic System Modeling Some Biological Phenomena
WU Shaohua; CHEN Hua
2011-01-01
In this paper, we study a nonlinear hyperbolic-parabolic system modeling some biological phenomena. By semigroup theory and Leray-Schauder fixed point argument, the local existence and uniqueness of the weak solutions for this system are proved. For the spatial dimension N = 1, the global existence of the weak solution will be established by the bootstrap argument.
Shubina, Maria
2016-09-01
In this paper, we investigate the one-dimensional parabolic-parabolic Patlak-Keller-Segel model of chemotaxis. For the case when the diffusion coefficient of chemical substance is equal to two, in terms of travelling wave variables the reduced system appears integrable and allows the analytical solution. We obtain the exact soliton solutions, one of which is exactly the one-soliton solution of the Korteweg-de Vries equation.
Tropospheric Refraction Modeling Using Ray-Tracing and Parabolic Equation
P. Pechac
2005-12-01
Full Text Available Refraction phenomena that occur in the lower atmospheresignificantly influence the performance of wireless communicationsystems. This paper provides an overview of corresponding computationalmethods. Basic properties of the lower atmosphere are mentioned.Practical guidelines for radiowave propagation modeling in the loweratmosphere using ray-tracing and parabolic equation methods are given.In addition, a calculation of angle-of-arrival spectra is introducedfor multipath propagation simulations.
Abacus models for parabolic quotients of affine Weyl groups
Hanusa, Christopher R H
2011-01-01
We introduce abacus diagrams that describe minimal length coset representatives in affine Weyl groups of types B, C, and D. These abacus diagrams use a realization of the affine Weyl group of type C due to Eriksson to generalize a construction of James for the symmetric group. We also describe several combinatorial models for these parabolic quotients that generalize classical results in affine type A related to core partitions.
Reverberation Modelling Using a Parabolic Equation Method
2012-10-01
et possiblement des échos de cibles. L’objet du présent contrat est une étude du recours à un modèle à équation parabolique, en particulier le...obtained by the ‘PE method’ were primarily compared to results obtained from a proprietary ray-based model provided by Brooke Numerical Services (BNS... Services . Target echo estimates are also compared to the BNS ray model result. In all cases but one the reference data is plotted as a solid red line
On purpose simulation model for molten salt CSP parabolic trough
Caranese, Carlo; Matino, Francesca; Maccari, Augusto
2017-06-01
The utilization of computer codes and simulation software is one of the fundamental aspects for the development of any kind of technology and, in particular, in CSP sector for researchers, energy institutions, EPC and others stakeholders. In that extent, several models for the simulation of CSP plant have been developed with different main objectives (dynamic simulation, productivity analysis, techno economic optimization, etc.), each of which has shown its own validity and suitability. Some of those models have been designed to study several plant configurations taking into account different CSP plant technologies (Parabolic trough, Linear Fresnel, Solar Tower or Dish) and different settings for the heat transfer fluid, the thermal storage systems and for the overall plant operating logic. Due to a lack of direct experience of Molten Salt Parabolic Trough (MSPT) commercial plant operation, most of the simulation tools do not foresee a suitable management of the thermal energy storage logic and of the solar field freeze protection system, but follow standard schemes. ASSALT, Ase Software for SALT csp plants, has been developed to improve MSPT plant's simulations, by exploiting the most correct operational strategies in order to provide more accurate technical and economical results. In particular, ASSALT applies MSPT specific control logics for the electric energy production and delivery strategy as well as the operation modes of the Solar Field in off-normal sunshine condition. With this approach, the estimated plant efficiency is increased and the electricity consumptions required for the plant operation and management is drastically reduced. Here we present a first comparative study on a real case 55 MWe Molten Salt Parabolic Trough CSP plant placed in the Tibetan highlands, using ASSALT and SAM (System Advisor Model), which is a commercially available simulation tool.
Bilinear reduced order approximate model of parabolic distributed solar collectors
Elmetennani, Shahrazed
2015-07-01
This paper proposes a novel, low dimensional and accurate approximate model for the distributed parabolic solar collector, by means of a modified gaussian interpolation along the spatial domain. The proposed reduced model, taking the form of a low dimensional bilinear state representation, enables the reproduction of the heat transfer dynamics along the collector tube for system analysis. Moreover, presented as a reduced order bilinear state space model, the well established control theory for this class of systems can be applied. The approximation efficiency has been proven by several simulation tests, which have been performed considering parameters of the Acurex field with real external working conditions. Model accuracy has been evaluated by comparison to the analytical solution of the hyperbolic distributed model and its semi discretized approximation highlighting the benefits of using the proposed numerical scheme. Furthermore, model sensitivity to the different parameters of the gaussian interpolation has been studied.
The parabolic Anderson model random walk in random potential
König, Wolfgang
2016-01-01
This is a comprehensive survey on the research on the parabolic Anderson model – the heat equation with random potential or the random walk in random potential – of the years 1990 – 2015. The investigation of this model requires a combination of tools from probability (large deviations, extreme-value theory, e.g.) and analysis (spectral theory for the Laplace operator with potential, variational analysis, e.g.). We explain the background, the applications, the questions and the connections with other models and formulate the most relevant results on the long-time behavior of the solution, like quenched and annealed asymptotics for the total mass, intermittency, confinement and concentration properties and mass flow. Furthermore, we explain the most successful proof methods and give a list of open research problems. Proofs are not detailed, but concisely outlined and commented; the formulations of some theorems are slightly simplified for better comprehension.
2015-06-01
HIGHER-ORDER TREATMENTS OF BOUNDARY CONDITIONS IN SPLIT-STEP FOURIER PARABOLIC EQUATION MODELS by Savas Erdim June 2015 Thesis Advisor...CONDITIONS IN SPLIT-STEP FOURIER PARABOLIC EQUATION MODELS 5. FUNDING NUMBERS 6. AUTHOR(S) Savas Erdim 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES... Parabolic equation models solved using the split-step Fourier (SSF) algorithm, such as the Monterey Miami Parabolic Equation model, are commonly used
Large mass self-similar solutions of the parabolic-parabolic Keller-Segel model of chemotaxis.
Biler, Piotr; Corrias, Lucilla; Dolbeault, Jean
2011-07-01
In two space dimensions, the parabolic-parabolic Keller-Segel system shares many properties with the parabolic-elliptic Keller-Segel system. In particular, solutions globally exist in both cases as long as their mass is less than a critical threshold M(c). However, this threshold is not as clear in the parabolic-parabolic case as it is in the parabolic-elliptic case, in which solutions with mass above M(c) always blow up. Here we study forward self-similar solutions of the parabolic-parabolic Keller-Segel system and prove that, in some cases, such solutions globally exist even if their total mass is above M(c), which is forbidden in the parabolic-elliptic case.
Parabolic Trough Photovoltaic/Thermal Collectors: Design and Simulation Model
Laura Vanoli
2012-10-01
Full Text Available This paper presents a design procedure and a simulation model of a novel concentrating PVT collector. The layout of the PVT system under investigation was derived from a prototype recently presented in literature and commercially available. The prototype consisted in a parabolic trough concentrator and a linear triangular receiver. In that prototype, the bottom surfaces of the receiver are equipped with mono-crystalline silicon cells whereas the top surface is covered by an absorbing surface. The aperture area of the parabola was covered by a glass in order to improve the thermal efficiency of the system. In the modified version of the collector considered in this paper, two changes are implemented: the cover glass was eliminated and the mono-crystalline silicon cells were replaced by triple-junction cells. In order to analyze PVT performance, a detailed mathematical model was implemented. This model is based on zero-dimensional energy balances. The simulation model calculates the temperatures of the main components of the system and the main energy flows Results showed that the performance of the system is excellent even when the fluid temperature is very high (>100 °C. Conversely, both electrical and thermal efficiencies dramatically decrease when the incident beam radiation decreases.
Linearization models for parabolic dynamical systems via Abel's functional equation
Elin, Mark; Reich, Simeon; Shoikhet, David
2009-01-01
We study linearization models for continuous one-parameter semigroups of parabolic type. In particular, we introduce new limit schemes to obtain solutions of Abel's functional equation and to study asymptotic behavior of such semigroups. The crucial point is that these solutions are univalent functions convex in one direction. In a parallel direction, we find analytic conditions which determine certain geometric properties of those functions, such as the location of their images in either a half-plane or a strip, and their containing either a half-plane or a strip. In the context of semigroup theory these geometric questions may be interpreted as follows: is a given one-parameter continuous semigroup either an outer or an inner conjugate of a group of automorphisms? In other words, the problem is finding a fractional linear model of the semigroup which is defined by a group of automorphisms of the open unit disk. Our results enable us to establish some new important analytic and geometric characteristics of t...
A Parabolic Equation Approach to Modeling Acousto-Gravity Waves for Local Helioseismology
Del Bene, Kevin; Lingevitch, Joseph; Doschek, George
2016-08-01
A wide-angle parabolic-wave-equation algorithm is developed and validated for local-helioseismic wave propagation. The parabolic equation is derived from a factorization of the linearized acousto-gravity wave equation. We apply the parabolic-wave equation to modeling acoustic propagation in a plane-parallel waveguide with physical properties derived from helioseismic data. The wavenumber power spectrum and wave-packet arrival-time structure for receivers in the photosphere with separation up to 30° is computed, and good agreement is demonstrated with measured values and a reference spectral model.
Parabolic Anderson model with a finite number of moving catalysts
Castell, Fabienne; Maillard, Grégory
2010-01-01
We consider the parabolic Anderson model (PAM) which is given by the equation $\\partial u/\\partial t = \\kappa\\Delta u + \\xi u$ with $u\\colon\\, \\Z^d\\times [0,\\infty)\\to \\R$, where $\\kappa \\in [0,\\infty)$ is the diffusion constant, $\\Delta$ is the discrete Laplacian, and $\\xi\\colon\\,\\Z^d\\times [0,\\infty)\\to\\R$ is a space-time random environment that drives the equation. The solution of this equation describes the evolution of a ``reactant'' $u$ under the influence of a ``catalyst'' $\\xi$. In the present paper we focus on the case where $\\xi$ is a system of $n$ independent simple random walks each with step rate $2d\\rho$ and starting from the origin. We study the \\emph{annealed} Lyapunov exponents, i.e., the exponential growth rates of the successive moments of $u$ w.r.t.\\ $\\xi$ and show that these exponents, as a function of the diffusion constant $\\kappa$ and the rate constant $\\rho$, behave differently depending on the dimension $d$. In particular, we give a description of the intermittent behavior of the sys...
Three-dimensional parabolic equation modeling of mesoscale eddy deflection.
Heaney, Kevin D; Campbell, Richard L
2016-02-01
The impact of mesoscale oceanography, including ocean fronts and eddies, on global scale low-frequency acoustics is examined using a fully three-dimensional parabolic equation model. The narrowband acoustic signal, for frequencies from 2 to 16 Hz, is simulated from a seismic event on the Kerguellen Plateau in the South Indian Ocean to an array of receivers south of Ascension Island in the South Atlantic, a distance of 9100 km. The path was chosen for its relevance to seismic detections from the HA10 Ascension Island station of the International Monitoring System, for its lack of bathymetric interaction, and for the dynamic oceanography encountered as the sound passes the Cape of Good Hope. The acoustic field was propagated through two years (1992 and 1993) of the eddy-permitting ocean state estimation ECCO2 (Estimating the Circulation and Climate of the Ocean, Phase II) system. The range of deflection of the back-azimuth was 1.8° with a root-mean-square of 0.34°. The refraction due to mesoscale oceanography could therefore have significant impacts upon localization of distant low-frequency sources, such as seismic or nuclear test events.
Study on Clutter Model and Characteristics of Airborne Radar with Parabolic Conformal Phased Array
Hao Jiang; Nini Rao; Xingbo Chen; Jiabin Zhou; Chaoyang Qiu; Wen Zhai; Zhimei Hao
2016-01-01
The studies on clutter modeling and suppression of airborne radar with a parabolic conformal array are uncommon due to the complexity of this type of antenna array configuration. The correct understanding of clutter characteristics for airborne radar with a parabolic conformal antenna array is the prerequisite and foundation of optimal suppression of this type of clutter. This paper establishes the model of clutter echo of airborne parabolic conformal phased array radar and analyzes the structure characteristics and the distribution features of this type of clutter. The simulation results show that this type of clutter has the following characteristics: 1) The main lobe on the azimuth is seriously broadened, 2) the power spectrum presents strong heterogeneity, and 3) the freedom degrees are high. Based on the existing related clutter suppression methods, we verified the correctness of the constructed clutter model. This work has an important guidance to further study on clutter suppression methods in airborne parabolic conformal array radar.
Parabolic Anderson Model in a Dynamic Random Environment: Random Conductances
Erhard, D.; den Hollander, F.; Maillard, G.
2016-06-01
The parabolic Anderson model is defined as the partial differential equation ∂ u( x, t)/ ∂ t = κ Δ u( x, t) + ξ( x, t) u( x, t), x ∈ ℤ d , t ≥ 0, where κ ∈ [0, ∞) is the diffusion constant, Δ is the discrete Laplacian, and ξ is a dynamic random environment that drives the equation. The initial condition u( x, 0) = u 0( x), x ∈ ℤ d , is typically taken to be non-negative and bounded. The solution of the parabolic Anderson equation describes the evolution of a field of particles performing independent simple random walks with binary branching: particles jump at rate 2 d κ, split into two at rate ξ ∨ 0, and die at rate (- ξ) ∨ 0. In earlier work we looked at the Lyapunov exponents λ p(κ ) = limlimits _{tto ∞} 1/t log {E} ([u(0,t)]p)^{1/p}, quad p in {N} , qquad λ 0(κ ) = limlimits _{tto ∞} 1/2 log u(0,t). For the former we derived quantitative results on the κ-dependence for four choices of ξ : space-time white noise, independent simple random walks, the exclusion process and the voter model. For the latter we obtained qualitative results under certain space-time mixing conditions on ξ. In the present paper we investigate what happens when κΔ is replaced by Δ𝓚, where 𝓚 = {𝓚( x, y) : x, y ∈ ℤ d , x ˜ y} is a collection of random conductances between neighbouring sites replacing the constant conductances κ in the homogeneous model. We show that the associated annealed Lyapunov exponents λ p (𝓚), p ∈ ℕ, are given by the formula λ p({K} ) = {sup} {λ p(κ ) : κ in {Supp} ({K} )}, where, for a fixed realisation of 𝓚, Supp(𝓚) is the set of values taken by the 𝓚-field. We also show that for the associated quenched Lyapunov exponent λ 0(𝓚) this formula only provides a lower bound, and we conjecture that an upper bound holds when Supp(𝓚) is replaced by its convex hull. Our proof is valid for three classes of reversible ξ, and for all 𝓚
Soneson, Joshua E
2017-04-01
Wide-angle parabolic models are commonly used in geophysics and underwater acoustics but have seen little application in medical ultrasound. Here, a wide-angle model for continuous-wave high-intensity ultrasound beams is derived, which approximates the diffraction process more accurately than the commonly used Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation without increasing implementation complexity or computing time. A method for preventing the high spatial frequencies often present in source boundary conditions from corrupting the solution is presented. Simulations of shallowly focused axisymmetric beams using both the wide-angle and standard parabolic models are compared to assess the accuracy with which they model diffraction effects. The wide-angle model proposed here offers improved focusing accuracy and less error throughout the computational domain than the standard parabolic model, offering a facile method for extending the utility of existing KZK codes.
ON A PARABOLIC FREE BOUNDARY EQUATION MODELING PRICE FORMATION
MARKOWICH, P. A.
2009-10-01
We discuss existence and uniqueness of solutions for a one-dimensional parabolic evolution equation with a free boundary. This problem was introduced by Lasry and Lions as description of the dynamical formation of the price of a trading good. Short time existence and uniqueness is established by a contraction argument. Then we discuss the issue of global-in-time-extension of the local solution which is closely related to the regularity of the free boundary. We also present numerical results. © 2009 World Scientific Publishing Company.
Brownian motion and parabolic Anderson model in a renormalized Poisson potential
Chen, Xia; Kulik, Alexey M.
2012-01-01
A method known as renormalization is proposed for constructing some more physically realistic random potentials in a Poisson cloud. The Brownian motion in the renormalized random potential and related parabolic Anderson models are modeled. With the renormalization, for example, the models consistent to Newton’s law of universal attraction can be rigorously constructed.
Tunneling of an energy eigenstate through a parabolic barrier viewed from Wigner phase space
Heim, D.M.; Schleich, W.P.; Alsing, P.M.
2013-01-01
We analyze the tunneling of a particle through a repulsive potential resulting from an inverted harmonic oscillator in the quantum mechanical phase space described by the Wigner function. In particular, we solve the partial differential equations in phase space determining the Wigner function...... of an energy eigenstate of the inverted oscillator. The reflection or transmission coefficients R or T are then given by the total weight of all classical phase-space trajectories corresponding to energies below, or above the top of the barrier given by the Wigner function....
Global Existence for a Parabolic-hyperbolic Free Boundary Problem Modelling Tumor Growth
Shang-bin Cui; Xue-mei Wei
2005-01-01
In this paper we study a free boundary problem modelling tumor growth, proposed by A. Friedman in 2004. This free boundary problem involves a nonlinear second-order parabolic equation describing the diffusion of nutrient in the tumor, and three nonlinear first-order hyperbolic equations describing the evolution of proliferative cells, quiescent cells and dead cells, respectively. By applying Lp theory of parabolic equations, the characteristic theory of hyperbolic equations, and the Banach fixed point theorem, we prove that this problem has a unique global classical solution.
A parabolic model of drag coefficient for storm surge simulation in the South China Sea.
Peng, Shiqiu; Li, Yineng
2015-10-26
Drag coefficient (Cd) is an essential metric in the calculation of momentum exchange over the air-sea interface and thus has large impacts on the simulation or forecast of the upper ocean state associated with sea surface winds such as storm surges. Generally, Cd is a function of wind speed. However, the exact relationship between Cd and wind speed is still in dispute, and the widely-used formula that is a linear function of wind speed in an ocean model could lead to large bias at high wind speed. Here we establish a parabolic model of Cd based on storm surge observations and simulation in the South China Sea (SCS) through a number of tropical cyclone cases. Simulation of storm surges for independent Tropical cyclones (TCs) cases indicates that the new parabolic model of Cd outperforms traditional linear models.
Modeling of concentration polarization in a reverse osmosis channel with parabolic crossflow.
Liu, Cui; Morse, Audra; Rainwater, Ken; Song, Lianfa
2014-01-01
Concentration polarization in narrow reverse osmosis channels with parabolic crossflow was numerically simulated with finite different equations related to permeate velocity, crossflow velocity, average salt concentration, and wall salt concentration. A significant new theoretical development was the determination of two correction functions, F2 and F3, in the governing equation for average salt concentration. Simulations of concentration polarization under various conditions were then presented to describe the features of the new model as well as discussions about the differences of concentration polarizations of the more realistic parabolic flow with those when plug flow or shear flow was assumed. The situations in which the simpler models based on shear or plug flow can be used were indicated. Concentration polarization was also simulated for various conditions to show the applicability of the model and general features of concentration polarization in a narrow, long reverse osmosis channel.
Parabolic Trough Reference Plant for Cost Modeling with the Solar Advisor Model (SAM)
Turchi, C.
2010-07-01
This report describes a component-based cost model developed for parabolic trough solar power plants. The cost model was developed by the National Renewable Energy Laboratory (NREL), assisted by WorleyParsons Group Inc., for use with NREL's Solar Advisor Model (SAM). This report includes an overview and explanation of the model, two summary contract reports from WorleyParsons, and an Excel spreadsheet for use with SAM. The cost study uses a reference plant with a 100-MWe capacity and six hours of thermal energy storage. Wet-cooling and dry-cooling configurations are considered. The spreadsheet includes capital and operating cost by component to allow users to estimate the impact of changes in component costs.
A parabolic model to control quantum interference in T-shaped molecular junctions
Nozaki, Daijiro; Sevincli, Haldun; Avdoshenko, Stanislav M.;
2013-01-01
Quantum interference (QI) effects in molecular devices have drawn increasing attention over the past years due to their unique features observed in the conductance spectrum. For the further development of single molecular devices exploiting QI effects, it is of great theoretical and practical int...... and the main conduction channel from measurements in the case of orthogonal basis. The results obtained within the parabolic model are validated using density-functional based quantum transport calculations in realistic T-shaped molecular junctions....
A parabolic model to control quantum interference in T-shaped molecular junctions.
Nozaki, Daijiro; Sevinçli, Hâldun; Avdoshenko, Stanislav M; Gutierrez, Rafael; Cuniberti, Gianaurelio
2013-09-07
Quantum interference (QI) effects in molecular devices have drawn increasing attention over the past years due to their unique features observed in the conductance spectrum. For the further development of single molecular devices exploiting QI effects, it is of great theoretical and practical interest to develop simple methods controlling the emergence and the positions of QI effects like anti-resonances or Fano line shapes in conductance spectra. In this work, starting from a well-known generic molecular junction with a side group (T-shaped molecule), we propose a simple graphical method to visualize the conditions for the appearance of quantum interference, Fano resonances or anti-resonances, in the conductance spectrum. By introducing a simple graphical representation (parabolic diagram), we can easily visualize the relation between the electronic parameters and the positions of normal resonant peaks and anti-resonant peaks induced by quantum interference in the conductance spectrum. This parabolic model not only can predict the emergence and energetic position of quantum interference from a few electronic parameters but also can enable one to know the coupling between the side group and the main conduction channel from measurements in the case of orthogonal basis. The results obtained within the parabolic model are validated using density-functional based quantum transport calculations in realistic T-shaped molecular junctions.
Wang, Jun-Wei; Wu, Huai-Ning; Li, Han-Xiong
2012-06-01
In this paper, a distributed fuzzy control design based on Proportional-spatial Derivative (P-sD) is proposed for the exponential stabilization of a class of nonlinear spatially distributed systems described by parabolic partial differential equations (PDEs). Initially, a Takagi-Sugeno (T-S) fuzzy parabolic PDE model is proposed to accurately represent the nonlinear parabolic PDE system. Then, based on the T-S fuzzy PDE model, a novel distributed fuzzy P-sD state feedback controller is developed by combining the PDE theory and the Lyapunov technique, such that the closed-loop PDE system is exponentially stable with a given decay rate. The sufficient condition on the existence of an exponentially stabilizing fuzzy controller is given in terms of a set of spatial differential linear matrix inequalities (SDLMIs). A recursive algorithm based on the finite-difference approximation and the linear matrix inequality (LMI) techniques is also provided to solve these SDLMIs. Finally, the developed design methodology is successfully applied to the feedback control of the Fitz-Hugh-Nagumo equation.
Parabolic Free Boundary Price Formation Models Under Market Size Fluctuations
Markowich, Peter A.
2016-10-04
In this paper we propose an extension of the Lasry-Lions price formation model which includes uctuations of the numbers of buyers and vendors. We analyze the model in the case of deterministic and stochastic market size uctuations and present results on the long time asymptotic behavior and numerical evidence and conjectures on periodic, almost periodic, and stochastic uctuations. The numerical simulations extend the theoretical statements and give further insights into price formation dynamics.
Parabolic problems with parameters arising in evolution model for phytromediation
Sahmurova, Aida; Shakhmurov, Veli
2012-12-01
The past few decades, efforts have been made to clean sites polluted by heavy metals as chromium. One of the new innovative methods of eradicating metals from soil is phytoremediation. This uses plants to pull metals from the soil through the roots. This work develops a system of differential equations with parameters to model the plant metal interaction of phytoremediation (see [1]).
A new elliptic-parabolic yield surface model revised by an adaptive criterion for granular soils
无
2010-01-01
An adaptive criterion for shear yielding as well as shear failure of soils is proposed in this paper to address the fact that most criteria,including the Mohr-Coulomb criterion,the Lade criterion and the Matsuoka-Nakai criterion,cannot agree well with the experimental results when the value of the intermediate principal stress parameter is too big.The new criterion can adjust an adaptive parameter based on the experimental results in order to make the theoretical calculations fit the test results more accurately.The original elliptic-parabolic yield surface model can capture both soil contraction and dilation behaviors.However,it normally over-predicts the soil strength due to its application of the Extended Mises criterion.A new elliptic-parabolic yield surface mode is presented in this paper,which introduces the adaptive criterion in three-dimensional principal stress space.The new model can well model the stress-strain behavior of soils under general stress conditions.Compared to the original model which can only simulate soil behavior under triaxial compression conditions,the new model can simulate soil behaviors under both triaxial compression conditions and general stress conditions.
Coupling and noise induced spiking-bursting transition in a parabolic bursting model.
Ji, Lin; Zhang, Jia; Lang, Xiufeng; Zhang, Xiuhui
2013-03-01
The transition from tonic spiking to bursting is an important dynamic process that carry physiologically relevant information. In this work, coupling and noise induced spiking-bursting transition is investigated in a parabolic bursting model with specific discussion on their cooperation effects. Fast/slow analysis shows that weak coupling may help to induce the bursting by changing the geometric property of the fast subsystem so that the original unstable periodical solution are stabilized. It turned out that noise can play the similar stabilization role and induce bursting at appropriate moderate intensity. However, their cooperation may either strengthen or weaken the overall effect depending on the choice of noise level.
Development of a finite element model for the simulation of parabolic impact of sandwich panels
Ram Ramakrishnan, Karthik; Guérard, Sandra; Mahéo, Laurent; Shankar, Krishna; Viot, Philippe
2015-09-01
Sandwich panels are lightweight structures of two thin high strength facesheets bonded to either side of a thick low density core such as foams and honeycombs. It is necessary to study the impact response of sandwich structures in order to ensure the reliability and safety of these structures. The response of sandwich panels to impact loading is usually studied for impact at normal angle of incidence. In real engineering situations, the structures are more frequently loaded at some oblique angle or with a complex trajectory. It is easy to carry out normal impact tests using devices like the drop tower, but impacts at oblique angles are difficult to characterise experimentally. A tri-dimensional impact device called Hexapod has been developed to experimentally study the impact loading of sandwich plates with a parabolic trajectory. The Hexapod is a modified Gough-Stewart platform that can be moved independently in the six degrees of freedom, corresponding to three translation axes and three rotation axes. In this paper, an approach for modelling the parabolic impact of sandwich structures with thin metallic facesheets and polymer foam core using commercial finite element code LS-DYNA software is presented. The results of the FE model of sandwich panels are compared with experimental data in terms of the time history of vertical and horizontal components of force. A comparison of the strain history obtained from Digital Image Correlation and LS-Dyna model are also presented.
Development of a finite element model for the simulation of parabolic impact of sandwich panels
Ramakrishnan Karthik Ram
2015-01-01
Full Text Available Sandwich panels are lightweight structures of two thin high strength facesheets bonded to either side of a thick low density core such as foams and honeycombs. It is necessary to study the impact response of sandwich structures in order to ensure the reliability and safety of these structures. The response of sandwich panels to impact loading is usually studied for impact at normal angle of incidence. In real engineering situations, the structures are more frequently loaded at some oblique angle or with a complex trajectory. It is easy to carry out normal impact tests using devices like the drop tower, but impacts at oblique angles are difficult to characterise experimentally. A tri-dimensional impact device called Hexapod has been developed to experimentally study the impact loading of sandwich plates with a parabolic trajectory. The Hexapod is a modified Gough-Stewart platform that can be moved independently in the six degrees of freedom, corresponding to three translation axes and three rotation axes. In this paper, an approach for modelling the parabolic impact of sandwich structures with thin metallic facesheets and polymer foam core using commercial finite element code LS-DYNA software is presented. The results of the FE model of sandwich panels are compared with experimental data in terms of the time history of vertical and horizontal components of force. A comparison of the strain history obtained from Digital Image Correlation and LS-Dyna model are also presented.
Perfectly matched layer for an elastic parabolic equation model in ocean acoustics
Xu, Chuanxiu; Zhang, Haigang; Piao, Shengchun; Yang, Shi'e.; Sun, Sipeng; Tang, Jun
2017-02-01
The perfectly matched layer (PML) is an effective technique for truncating unbounded domains with minimal spurious reflections. A fluid parabolic equation (PE) model applying PML technique was previously used to analyze the sound propagation problem in a range-dependent waveguide (Lu and Zhu, 2007). However, Lu and Zhu only considered a standard fluid PE to demonstrate the capability of the PML and did not take improved one-way models into consideration. They applied a [1/1] Padé approximant to the parabolic equation. The higher-order PEs are more accurate than standard ones when a very large angle propagation is considered. As for range-dependent problems, the techniques to handle the vertical interface between adjacent regions are mainly energy conserving and single-scattering. In this paper, the PML technique is generalized to the higher order elastic PE, as is to the higher order fluid PE. The correction of energy conserving is used in range-dependent waveguides. Simulation is made in both acoustic cases and seismo-acoustic cases. Range-independent and range-dependent waveguides are both adopted to test the accuracy and efficiency of this method. The numerical results illustrate that a PML is much more effective than an artificial absorbing layer (ABL) both in acoustic and seismo-acoustic sound propagation modeling.
A Fovea Localization Scheme Using Vessel Origin-Based Parabolic Model
Chun-Yuan Yu
2014-09-01
Full Text Available At the center of the macula, fovea plays an important role in computer-aided diagnosis. To locate the fovea, this paper proposes a vessel origin (VO-based parabolic model, which takes the VO as the vertex of the parabola-like vasculature. Image processing steps are applied to accurately locate the fovea on retinal images. Firstly, morphological gradient and the circular Hough transform are used to find the optic disc. The structure of the vessel is then segmented with the line detector. Based on the characteristics of the VO, four features of VO are extracted, following the Bayesian classification procedure. Once the VO is identified, the VO-based parabolic model will locate the fovea. To find the fittest parabola and the symmetry axis of the retinal vessel, an Shift and Rotation (SR-Hough transform that combines the Hough transform with the shift and rotation of coordinates is presented. Two public databases of retinal images, DRIVE and STARE, are used to evaluate the proposed method. The experiment results show that the average Euclidean distances between the located fovea and the fovea marked by experts in two databases are 9.8 pixels and 30.7 pixels, respectively. The results are stronger than other methods and thus provide a better macular detection for further disease discovery.
Zhai Rongrong
2013-01-01
Full Text Available The thermal oil is applied as the heat transfer fluid in a solar parabolic trough collector system. Firstly, the system dynamic model was established and validated by the real operating data in typical summer and spring days in references. Secondly, the alteration characteristics of different solar radiation, inlet water temperature and flow rate, and collectors’ area and length are analyzed and compared with the normal working condition. The model can be used for studying, system designing, and better understanding of the performance of parabolic trough systems.
Saša Pavlović
2015-08-01
Full Text Available The paper presents a physical and mathematical model of the new offset type parabolic concentrator and a numerical procedure for predicting its optical performances. Also presented is the process of design and optical ray tracing analysis of a low cost solar concentrator for medium temperature applications. This study develops and applies a new mathematical model for estimating the intercept factor of the solar concentrator based on its geometrical and optical behavior. The solar concentrating system consists of three offset parabolic dish reflectors and a solar thermal absorber at the focus. Two types of absorbers are discussed. One is a flat plate circular absorber and the other a spiral smooth pipe absorber. The simulation results could serve as a useful reference for design and optimization of offset parabolic concentrators.
Caro, Florian; Saad, Mazen
2012-01-01
Our goal is the mathematical analysis of a two phase (liquid and gas) two components (water and hydrogen) system modeling the hydrogen displacement in a storage site for radioactive waste. We suppose that the water is only in the liquid phase and is incompressible. The hydrogen in the gas phase is supposed compressible and could be dissolved into the water with the Henry's law. The flow is described by the conservation of the mass of each components. The model is treated without simplified assumptions on the gas density. This model is degenerated due to vanishing terms. We establish an existence result for the nonlinear degenerate parabolic system based on new energy estimate on pressures.
Caro, Florian
2013-09-01
Our goal is the mathematical analysis of a two phase (liquid and gas) two components (water and hydrogen) system modeling the hydrogen displacement in a storage site for radioactive waste. We suppose that the water is only in the liquid phase and is incompressible. The hydrogen in the gas phase is supposed compressible and could be dissolved into the water with the Henry law. The flow is described by the conservation of the mass of each components. The model is treated without simplified assumptions on the gas density. This model is degenerated due to vanishing terms. We establish an existence result for the nonlinear degenerate parabolic system based on new energy estimate on pressures.
Wen, Zijuan; Fan, Meng; Asiri, Asim M; Alzahrani, Ebraheem O; El-Dessoky, Mohamed M; Kuang, Yang
2017-04-01
This paper studies the global existence and uniqueness of classical solutions for a generalized quasilinear parabolic equation with appropriate initial and mixed boundary conditions. Under some practicable regularity criteria on diffusion item and nonlinearity, we establish the local existence and uniqueness of classical solutions based on a contraction mapping. This local solution can be continued for all positive time by employing the methods of energy estimates, Lp-theory, and Schauder estimate of linear parabolic equations. A straightforward application of global existence result of classical solutions to a density-dependent diffusion model of in vitro glioblastoma growth is also presented.
Modeling Flow Rate to Estimate Hydraulic Conductivity in a Parabolic Ceramic Water Filter
Ileana Wald
2012-01-01
Full Text Available In this project we model volumetric flow rate through a parabolic ceramic water filter (CWF to determine how quickly it can process water while still improving its quality. The volumetric flow rate is dependent upon the pore size of the filter, the surface area, and the height of water in the filter (hydraulic head. We derive differential equations governing this flow from the conservation of mass principle and Darcy's Law and find the flow rate with respect to time. We then use methods of calculus to find optimal specifications for the filter. This work is related to the research conducted in Dr. James R. Mihelcic's Civil and Environmental Engineering Lab at USF.
Escher, Joachim; Matioc, Bogdan-Vasile
2011-01-01
We prove global existence of nonnegative weak solutions to a degenerate parabolic system which models the interaction of two thin fluid films in a porous medium. Furthermore, we show that these weak solutions converge at an exponential rate towards flat equilibria.
Parabolic Trough Collector Cost Update for the System Advisor Model (SAM)
Kurup, Parthiv [National Renewable Energy Lab. (NREL), Golden, CO (United States); Turchi, Craig S. [National Renewable Energy Lab. (NREL), Golden, CO (United States)
2015-11-01
This report updates the baseline cost for parabolic trough solar fields in the United States within NREL's System Advisor Model (SAM). SAM, available at no cost at https://sam.nrel.gov/, is a performance and financial model designed to facilitate decision making for people involved in the renewable energy industry. SAM is the primary tool used by NREL and the U.S. Department of Energy (DOE) for estimating the performance and cost of concentrating solar power (CSP) technologies and projects. The study performed a bottom-up build and cost estimate for two state-of-the-art parabolic trough designs -- the SkyTrough and the Ultimate Trough. The SkyTrough analysis estimated the potential installed cost for a solar field of 1500 SCAs as $170/m^{2} +/- $6/m^{2}. The investigation found that SkyTrough installed costs were sensitive to factors such as raw aluminum alloy cost and production volume. For example, in the case of the SkyTrough, the installed cost would rise to nearly $210/m^{2} if the aluminum alloy cost was $1.70/lb instead of $1.03/lb. Accordingly, one must be aware of fluctuations in the relevant commodities markets to track system cost over time. The estimated installed cost for the Ultimate Trough was only slightly higher at $178/m^{2}, which includes an assembly facility of $11.6 million amortized over the required production volume. Considering the size and overall cost of a 700 SCA Ultimate Trough solar field, two parallel production lines in a fully covered assembly facility, each with the specific torque box, module and mirror jigs, would be justified for a full CSP plant.
Mathematical modeling of complex noise barriers
Hayek, S.I.
1982-01-01
Mathematical modeling of the noise reduction efficiency of highway noise barriers depends on the shape and absorptivity of the barrier, the influence of the impedance of the ground under the receiver, the atmospheric conditions as well as traffic details. The mathematical model for a barrier's noise reduction requires the knowledge of point-to-point acoustic diffraction models. In many instances, the shape of the barrier is simple; such as thin wall (edge), sharp wedge, and cylindrically topped berms. However, new designs of more efficient barriers have been investigated recently.
Bin Deng
2013-01-01
Full Text Available Parabolic-reflector antennas (PRAs, usually possessing rotation, are a particular type of targets of potential interest to the synthetic aperture radar (SAR community. This paper is aimed to investigate PRA’s scattering characteristics and then to extract PRA’s parameters from SAR returns, for supporting image interpretation and target recognition. We at first obtain both closed-form and numeric solutions to PRA’s backscattering by geometrical optics (GO, physical optics, and graphical electromagnetic computation, respectively. Based on the GO solution, a migratory scattering center model is at first presented for representing the movement of the specular point with aspect angle, and then a hybrid model, named the migratory/micromotion scattering center (MMSC model, is proposed for characterizing a rotating PRA in the SAR geometry, which incorporates PRA’s rotation into its migratory scattering center model. Additionally, we in detail analyze PRA’s radar characteristics on radar cross-section, high-resolution range profiles, time-frequency distribution, and 2D images, which also confirm the models proposed. A maximal likelihood estimator is developed for jointly solving the MMSC model for PRA’s multiple parameters by optimization. By exploiting the aforementioned characteristics, the coarse parameter estimation guarantees convergency upon global minima. The signatures recovered can be favorably utilized for SAR image interpretation and target recognition.
Chakrabarti, Rajarshi
2007-04-01
The paper demonstrates an elegant way of combining the normal mode analysis and the method of reactive flux to evaluate the time dependent transmission coefficient for a classical particle coupled to a set of harmonic oscillators, surmounting a one dimensional barrier. The author's analysis reproduces the results of Kohen and Tannor [J. Chem. Phys. 103, 6013 (1995)] and Bao [J. Chem. Phys. 124, 114103 (2006)]. Moreover the use of normal mode analysis has a better physical meaning.
Leading-order cross term correction of three-dimensional parabolic equation models.
Sturm, Frédéric
2016-01-01
The issue of handling a leading-order cross-multiplied term in three-dimensional (3D) parabolic equation (PE) based models is addressed. In particular, numerical results obtained incorporating a leading-order cross-term correction in an existing 3D PE model, written in cylindrical coordinates, based on higher-order Padé approximations in both depth and azimuth, and a splitting operator technique are reported. Note that the numerical algorithm proposed in this paper could be used in the future to update any 3D PE codes that neglect cross terms and use a splitting numerical technique. The 3D penetrable wedge benchmark problem is chosen to illustrate the accuracy of the now-fully wide-angle enhanced 3D PE model. The comparisons with a 3D reference solution based on the image source clearly show that handling the leading-order cross term in the 3D PE computation is sufficient to remove the phase errors inherent to any 3D PE models that neglect cross terms in their formulations.
Matioc, Bogdan-Vasile
2011-01-01
We prove global existence of nonnegative weak solutions for a strongly coupled, fourth order degenerate parabolic system governing the motion of two thin fluid layers in a porous medium when capillarity is the sole driving mechanism.
无
2008-01-01
The authors prove the local existence and uniqueness of weak solution of a hyperbolic-parabolic system and establish the global existence of the weak solution for this system for the spatial dimension n = 1.
Bilinear Approximate Model-Based Robust Lyapunov Control for Parabolic Distributed Collectors
Elmetennani, Shahrazed
2016-11-09
This brief addresses the control problem of distributed parabolic solar collectors in order to maintain the field outlet temperature around a desired level. The objective is to design an efficient controller to force the outlet fluid temperature to track a set reference despite the unpredictable varying working conditions. In this brief, a bilinear model-based robust Lyapunov control is proposed to achieve the control objectives with robustness to the environmental changes. The bilinear model is a reduced order approximate representation of the solar collector, which is derived from the hyperbolic distributed equation describing the heat transport dynamics by means of a dynamical Gaussian interpolation. Using the bilinear approximate model, a robust control strategy is designed applying Lyapunov stability theory combined with a phenomenological representation of the system in order to stabilize the tracking error. On the basis of the error analysis, simulation results show good performance of the proposed controller, in terms of tracking accuracy and convergence time, with limited measurement even under unfavorable working conditions. Furthermore, the presented work is of interest for a large category of dynamical systems knowing that the solar collector is representative of physical systems involving transport phenomena constrained by unknown external disturbances.
Chadzitaskos, Goce
2013-01-01
We present a proposal of a new type of telescopes using a rotating parabolic strip as the primary mirror. It is the most principal modification of the design of telescopes from the times of Galileo and Newton. In order to demonstrate the basic idea, the image of an artificial constellation observed by this kind of telescope was reconstructed using the techniques described in this article. As a working model of this new telescope, we have used an assembly of the primary mirror---a strip of acrylic glass parabolic mirror 40 cm long and 10 cm wid shaped as a parabolic cylinder of focal length 1 m---and an artificial constellation, a set of 5 apertures in a distance of 5 m illuminated from behind. In order to reconstruct the image, we made a series of snaps, each after a rotation of the constellation by 15 degrees. Using Matlab we reconstructed the image of the artificial constellation.
Dynamic Modeling of the Solar Field in Parabolic Trough Solar Power Plants
Lourdes A. Barcia
2015-11-01
Full Text Available Parabolic trough solar power plants use a thermal fluid to transfer thermal energy from solar radiation to a water-steam Rankine cycle in order to drive a turbine that, coupled to an electrical generator, produces electricity. These plants have a heat transfer fluid (HTF system with the necessary elements to transform solar radiation into heat and to transfer that thermal energy to the water-steam exchangers. In order to get the best possible performance in the Rankine cycle and, hence, in the thermal plant, it is necessary that the thermal fluid reach its maximum temperature when leaving the solar field (SF. Also, it is mandatory that the thermal fluid does not exceed the maximum operating temperature of the HTF, above which it degrades. It must be noted that the optimal temperature of the thermal fluid is difficult to obtain, since solar radiation can change abruptly from one moment to another. The aim of this document is to provide a model of an HTF system that can be used to optimize the control of the temperature of the fluid without interfering with the normal operation of the plant. The results obtained with this model will be contrasted with those obtained in a real plant.
Al-Nimr, Moh' d A.; Naji, Malak; Al-Wardat, Salem A. [Mechanical Engineering Department, Jordan University of Science and Technology, Irbid 22110, P.O. Box 3030 (Jordan)
2004-02-01
The thermal behavior of thin slab as described by the parabolic microscopic heat conduction model with variable thermal properties is investigated under two types of heating sources. These types are the unit step and the fluctuating harmonic heating sources. The considered thermal properties are the electron gas C{sub e} and the solid lattice C{sub L} total thermal capacities. It is found that the slab thermal behavior is more sensitive to the variation in C{sub e} as compared to the variation in C{sub L}. Assuming C{sub e} constant may cause an error of magnitude 19% while assuming C{sub L} constant causes an error of magnitude 5%. The sensitivity of the parabolic microscopic heat conduction model to the variation in C{sub e} is higher under the effect of a fluctuating heating source as compared to a unit step heating source. (authors)
Quenched Lyapunov exponent for the parabolic Anderson model in a dynamic random environment
Gärtner, Jürgen; Maillard, Grégory
2010-01-01
We continue our study of the parabolic Anderson equation $\\partial u/\\partial t = \\kappa\\Delta u + \\gamma\\xi u$ for the space-time field $u\\colon\\,\\Z^d\\times [0,\\infty)\\to\\R$, where $\\kappa \\in [0,\\infty)$ is the diffusion constant, $\\Delta$ is the discrete Laplacian, $\\gamma\\in (0,\\infty)$ is the coupling constant, and $\\xi\\colon\\,\\Z^d\\times [0,\\infty)\\to\\R$ is a space-time random environment that drives the equation. The solution of this equation describes the evolution of a "reactant" $u$ under the influence of a "catalyst" $\\xi$, both living on $\\Z^d$. In earlier work we considered three choices for $\\xi$: independent simple random walks, the symmetric exclusion process, and the symmetric voter model, all in equilibrium at a given density. We analyzed the \\emph{annealed} Lyapunov exponents, i.e., the exponential growth rates of the successive moments of $u$ w.r.t.\\ $\\xi$, and showed that these exponents display an interesting dependence on the diffusion constant $\\kappa$, with qualitatively different beha...
Tasel, Serdar F; Mumcuoglu, Erkan U; Hassanpour, Reza Z; Perkins, Guy
2016-06-01
Recent studies reveal that mitochondria take substantial responsibility in cellular functions that are closely related to aging diseases caused by degeneration of neurons. These studies emphasize that the membrane and crista morphology of a mitochondrion should receive attention in order to investigate the link between mitochondrial function and its physical structure. Electron microscope tomography (EMT) allows analysis of the inner structures of mitochondria by providing highly detailed visual data from large volumes. Computerized segmentation of mitochondria with minimum manual effort is essential to accelerate the study of mitochondrial structure/function relationships. In this work, we improved and extended our previous attempts to detect and segment mitochondria from transmission electron microcopy (TEM) images. A parabolic arc model was utilized to extract membrane structures. Then, curve energy based active contours were employed to obtain roughly outlined candidate mitochondrial regions. Finally, a validation process was applied to obtain the final segmentation data. 3D extension of the algorithm is also presented in this paper. Our method achieved an average F-score performance of 0.84. Average Dice Similarity Coefficient and boundary error were measured as 0.87 and 14nm respectively.
Tasel, Serdar F.; Mumcuoglu, Erkan U.; Hassanpour, Reza Z.; Perkins, Guy
2017-01-01
Recent studies reveal that mitochondria take substantial responsibility in cellular functions that are closely related to aging diseases caused by degeneration of neurons. These studies emphasize that the membrane and crista morphology of a mitochondrion should receive attention in order to investigate the link between mitochondrial function and its physical structure. Electron microscope tomography (EMT) allows analysis of the inner structures of mitochondria by providing highly detailed visual data from large volumes. Computerized segmentation of mitochondria with minimum manual effort is essential to accelerate the study of mitochondrial structure/function relationships. In this work, we improved and extended our previous attempts to detect and segment mitochondria from transmission electron microcopy (TEM) images. A parabolic arc model was utilized to extract membrane structures. Then, curve energy based active contours were employed to obtain roughly outlined candidate mitochondrial regions. Finally, a validation process was applied to obtain the final segmentation data. 3D extension of the algorithm is also presented in this paper. Our method achieved an average F-score performance of 0.84. Average Dice Similarity Coefficient and boundary error were measured as 0.87 and 14 nm respectively. PMID:26956730
Model assessment of protective barriers: Part 3
Fayer, M.J.; Rockhold, M.L.; Holford, D.J.
1992-02-01
Radioactive waste exists at the US Department of Energy's (DOE's) Hanford Site in a variety of locations, including subsurface grout and tank farms, solid waste burial grounds, and contaminated soil sites. Some of these waste sites may need to be isolated from percolating water to minimize the potential for transport of the waste to the ground water, which eventually discharges to the Columbia River. Multilayer protective barriers have been proposed as a means of limiting the flow of water through the waste sites (DOE 1987). A multiyear research program (managed jointly by Pacific Northwest Laboratory (PNL) and Westinghouse Hanford Company for the DOE) is aimed at assessing the performance of these barriers. One aspect of this program involves the use of computer models to predict barrier performance. Three modeling studies have already been conducted and a test plan was produced. The simulation work reported here was conducted by PNL and extends the previous modeling work. The purpose of this report are to understand phenomena that have been observed in the field and to provide information that can be used to improve hydrologic modeling of the protective barrier. An improved modeling capability results in better estimates of barrier performance. Better estimates can be used to improve the design of barriers and the assessment of their long-term performance.
MA Yong; WANG Wan-lu; LIAO Ke-jun; KONG Chun-yang
2004-01-01
For a low surface barrier, the energy band, barrier height and width of the space charge region at the surface of relatively large grains of ZnO are presented analytically on condition that the electron distribution obeys the Boltzmann statistics. It is shown that the temperature in the space charge distribution factor has an important effect on the energy band, barrier height and width of the space charge region. The depletion approximation is a model in which the temperature in the space charge distribution factor is zero. Our results are better than the depletion approximation.
2006-10-01
equation for sound waves in inhomogeneous moving media”, Acustica united with Acta Acustica , Vol 83(3), pp 455-460,1997. [3] L. Dallois, Ph. Blanc...propagation in a turbulent atmosphere within the parabolic approximation”, Acustica united with Acta Acustica , Vol 87(1), pp 659-669, 2001 [6] M. Karweit...approaches", Acta Acustica united with Acustica , 89 (6), 980-991, (2003). [40] Ph. Voisin, Ph. Blanc-Benon, "The influence of meteorological
Anand P Gokula; Rambhatla G Sastry
2015-12-01
In 3D gravity modelling, right rectangular vertical prism model with linear and nonlinear density and polyhedral bodies with linear density variation exist in geophysical literature. Here, we propose a vertical pyramid model with depth-wise parabolic density contrast variation. Initially, we validate our analytic expression against the gravity effect of a right rectangular parallelepiped of constant density contrast. We provide two synthetic examples and a case study for illustrating the effectiveness of our pyramid model in gravity modelling. The included case study of Los Angeles basin, California demonstrates the comparative advantages of our pyramid model over a conventional right rectangular vertical prism model. Our pyramid model could be quite effective as a building block for evaluating the gravity effect of an arbitrarily-shaped 3D or 2.5-D source(s).
Arkhipova, A. A.
2017-03-01
The Venttsel' problem in the model statement for quasilinear parabolic systems of equations with nondiagonal principal matrices is considered. It is only assumed that the principal matrices and the boundary condition are bounded with respect to the time variable. The partial smoothness of the weak solutions (Hölder continuity on a set of full measure up to the surface on which the Venttsel' condition is defined) is proved. The proof uses the A( t)-caloric approximation method, which was also used in [1] to investigate the regularity of the solution to the corresponding linear problem.
Computer simulations of the random barrier model
Schrøder, Thomas; Dyre, Jeppe
2002-01-01
A brief review of experimental facts regarding ac electronic and ionic conduction in disordered solids is given followed by a discussion of what is perhaps the simplest realistic model, the random barrier model (symmetric hopping model). Results from large scale computer simulations are presented......, focusing on universality of the ac response in the extreme disorder limit. Finally, some important unsolved problems relating to hopping models for ac conduction are listed....
A scaling limit theorem for the parabolic Anderson model with exponential potential
Lacoin, Hubert
2010-01-01
The parabolic Anderson problem is the Cauchy problem for the heat equation with random potential and localized initial condition. In this paper we consider potentials which are constant in time and independent exponentially distributed in space. We study the growth rate of the total mass of the solution in terms of weak and almost sure limit theorems, and the spatial spread of the mass in terms of a scaling limit theorem. The latter result shows that in this case, just like in the case of heavy tailed potentials, the mass gets trapped in a single relevant island with high probability.
Lomonaco, Luciana Luna Anna
2011-01-01
In this paper we introduce the notion of parabolic-like mapping, which is an object similar to a polynomial-like mapping, but with a parabolic external class, i.e. an external map with a parabolic fixed point. We prove a straightening theorem for parabolic-like maps, which states that any parabolic-like map of degree 2 is hybrid conjugate to a member of the family Per_1(1), and this member is unique (up to holomorphic conjugacy) if the filled Julia set of the parabolic-like map is connected.
Usta, Yasemin [Anyl Asansor Ltd (Turkey)], email: syusta@gmail.com; Baker, Derek [Middle East Technical University (Turkey)], email: dbaker@metu.edu.tr; Kaftanoglu, Bilgin [Atilim University (Turkey)], email: bilgink@atilim.edu.tr
2011-07-01
With the energy crisis and the increasing concerns about climate change, the interest in concentrating solar power (CSP) systems is growing in Turkey. The aim of this paper is to develop a model of a CSP system using a field of parabolic trough collectors and to assess the predicted performance of the system. A model was developed for a 30MWe solar generating system in Antalya, Turkey, using TRNSYS software, the solar thermal electric components library and information on an existing system in Kramer Junction, California, United States. Annual simulations were then performed for both systems in Antalya and California using weather data. It was found that the predictions were in good agreement with published data. In addition results showed that Antalya's system would generate 30% less than Kramer Junction's system on an annual basis. This paper provides useful information on modeling and simulation of CSP systems.
Mass concentration and aging in the parabolic Anderson model with doubly-exponential tails
Biskup, Marek; Koenig, Wolfgang; Santos, Renato Soares dos
2016-01-01
We study the solutions $u=u(x,t)$ to the Cauchy problem on $\\mathbb Z^d\\times(0,\\infty)$ for the parabolic equation $\\partial_t u=\\Delta u+\\xi u$ with initial data $u(x,0)=1_{\\{0\\}}(x)$. Here $\\Delta$ is the discrete Laplacian on $\\mathbb Z^d$ and $\\xi=(\\xi(z))_{z\\in\\mathbb Z^d}$ is an i.i.d.\\ random field with doubly-exponential upper tails. We prove that, for large $t$ and with large probability, a majority of the total mass $U(t):=\\sum_x u(x,t)$ of the solution resides in a bounded neighbo...
Gao, Nan; Xie, Changqing
2014-06-15
We generalize the concept of diffraction free beams to parabolic scaling beams (PSBs), whose normalized intensity scales parabolically during propagation. These beams are nondiffracting in the circular parabolic coordinate systems, and all the diffraction free beams of Durnin's type have counterparts as PSBs. Parabolic scaling Bessel beams with Gaussian apodization are investigated in detail, their nonparaxial extrapolations are derived, and experimental results agree well with theoretical predictions.
A model for the parabolic slices Per1(e2πip/q) in moduli space of quadratic rational maps
Uhre, Eva
2010-01-01
The notion of relatedness loci in the parabolic slices Per1(e2πip/q) in moduli space of quadratic rational maps is introduced. They are counterparts of the disconnectedness or escape locus in the slice of quadratic polynomials. A model for these loci is presented, and a strategy of proof of the f...
Duality between random trap and barrier models
Jack, Robert L [Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720 (United States); Sollich, Peter [Department of Mathematics, King' s College London, London WC2R 2LS (United Kingdom)
2008-08-15
We discuss the physical consequences of a duality between two models with quenched disorder, in which particles propagate in one dimension among random traps or across random barriers. We derive an exact relation between their diffusion fronts at fixed disorder and deduce from this that their disorder-averaged diffusion fronts are exactly equal. We use effective dynamics schemes to isolate the different physical processes by which particles propagate in the models and discuss how the duality arises from a correspondence between the rates for these different processes.
Metzger, Bernd
2011-01-01
Originally introduced in solid state physics to model amorphous materials and alloys exhibiting disorder induced metal-insulator transitions, the Anderson model $H_{\\omega}= -\\Delta + V_{\\omega} $ on $l^2(\\bZ^d)$ has become in mathematical physics as well as in probability theory a paradigmatic example for the relevance of disorder effects. Here $\\Delta$ is the discrete Laplacian and $V_{\\omega} = \\{V_{\\omega}(x): x \\in \\bZ^d\\}$ is an i.i.d. random field taking values in $\\bR$. A popular model in probability theory is the parabolic Anderson model (PAM), i.e. the discrete diffusion equation $\\partial_t u(x,t) =-H_{\\omega} u(x,t)$ on $ \\bZ^d \\times \\bR_+$, $u(x,0)=1$, where random sources and sinks are modelled by the Anderson Hamiltonian. A characteristic property of the solutions of (PAM) is the occurrence of intermittency peaks in the large time limit. These intermittency peaks determine the thermodynamic observables extensively studied in the probabilistic literature using path integral methods and the theo...
Parabolic trough systems; Parabolrinnensysteme
Geyer, M. [Flabeg Solar International GmbH (Germany); Lerchenmueller, H.; Wittwer, V. [Fraunhofer ISE, Freiburg (Germany); Haeberle, A. [PSE GmbH (Germany); Luepfert, E.; Hennecke, K. [DLR, Koeln (Germany); Schiel, W. [SBP (Germany); Brakmann, G. [Fichtner Solar GmbH (Germany)
2002-07-01
The technology of parabolic trough power plants is presented: History, comparative assessment of different types of parabolic trough collectors, fresnel collectors, solar tracking systems, thermal efficiency, further research, performance of the SEGS parabolic trough power station in California. [German] Die Technik von Parabolrinnen-Kraftwerken wird vorgestellt: Entwicklungsgeschichte, Vergleich verschiedener Parabolrinnenkollektoren, fresnel kollektoren, Nachfuehrsysteme, thermischer Wirkungsgrad, weiterer Forschungsbedarf und Betriebserfahrung mit dem SEGS Parabolrinnenkraftwerk in Kalifornien. (uke)
Caplan, R. M.; Mikić, Z.; Linker, J. A.; Lionello, R.
2017-05-01
We explore the performance and advantages/disadvantages of using unconditionally stable explicit super time-stepping (STS) algorithms versus implicit schemes with Krylov solvers for integrating parabolic operators in thermodynamic MHD models of the solar corona. Specifically, we compare the second-order Runge-Kutta Legendre (RKL2) STS method with the implicit backward Euler scheme computed using the preconditioned conjugate gradient (PCG) solver with both a point-Jacobi and a non-overlapping domain decomposition ILU0 preconditioner. The algorithms are used to integrate anisotropic Spitzer thermal conduction and artificial kinematic viscosity at time-steps much larger than classic explicit stability criteria allow. A key component of the comparison is the use of an established MHD model (MAS) to compute a real-world simulation on a large HPC cluster. Special attention is placed on the parallel scaling of the algorithms. It is shown that, for a specific problem and model, the RKL2 method is comparable or surpasses the implicit method with PCG solvers in performance and scaling, but suffers from some accuracy limitations. These limitations, and the applicability of RKL methods are briefly discussed.
Bosschaart, C.; Eisses, A.R.; Eerden, F.J.M. van der
2010-01-01
Amsterdam Airport Schiphol has organized a competition to design a noise mitigating measure along the 'Polderbaan' runway. Its main goal is to reduce the low frequency (LF) ground noise from starting aircraft. The winning concept is a flexible parabolic shaped noise barrier positioned relatively clo
Parabolic Dish Stirling Module
Washom, B.
1984-01-01
The design, manufacture, and assembly of a commercially designed parabolic dish Stirling 25 kWe module is examined. The cost, expected performance, design uniquenesses, and future commercial potential of this module, which is regarded as the most technically advanced in the parabolic dish industry is discussed.
Buerger, R.; Frid, H.; Karlsen, K.H.
2002-07-01
We consider a free boundary problem of a quasilinear strongly degenerate parabolic equation arising from a model of pressure filtration of flocculated suspensions. We provide definitions of generalized solutions of the free boundary problem in the framework of L2 divergence-measure fields. The formulation of boundary conditions is based on a Gauss-Green theorem for divergence-measure fields on bounded domains with Lipschitz deformable boundaries and avoids referring to traces of the solution. This allows to consider generalized solutions from a larger class than BV. Thus it is not necessary to derive the usual uniform estimates on spatial and time derivatives of the solutions of the corresponding regularized problem requires in the BV approach. We first prove existence and uniqueness of the solution of the regularized parabolic free boundary problem and then apply the vanishing viscosity method to prove existence of a generalized solution to the degenerate free boundary problem. (author)
Properties of Solutions for a Nonlinear Parabolic-Elliptic System Modelling Chemotaxis
钟新华
2002-01-01
@@ In 1970 Keller and Segel[1] proposed a mathematical model describing chemotactic aggregation of cellular slime molds which move preferentially towards relatively high concentraions of a chemical secreted by the amoebae themselves. With the cell density of the cellular slime molds u(x, t) and the concentration of the chemical substance v(x, t) at place x and time t, a simplified Keller-Segel model is described as the system
Residual Stresses Modeled in Thermal Barrier Coatings
Freborg, A. M.; Ferguson, B. L.; Petrus, G. J.; Brindley, W. J.
1998-01-01
Thermal barrier coating (TBC) applications continue to increase as the need for greater engine efficiency in aircraft and land-based gas turbines increases. However, durability and reliability issues limit the benefits that can be derived from TBC's. A thorough understanding of the mechanisms that cause TBC failure is a key to increasing, as well as predicting, TBC durability. Oxidation of the bond coat has been repeatedly identified as one of the major factors affecting the durability of the ceramic top coat during service. However, the mechanisms by which oxidation facilitates TBC failure are poorly understood and require further characterization. In addition, researchers have suspected that other bond coat and top coat factors might influence TBC thermal fatigue life, both separately and through interactions with the mechanism of oxidation. These other factors include the bond coat coefficient of thermal expansion, the bond coat roughness, and the creep behavior of both the ceramic and bond coat layers. Although it is difficult to design an experiment to examine these factors unambiguously, it is possible to design a computer modeling "experiment" to examine the action and interaction of these factors, as well as to determine failure drivers for TBC's. Previous computer models have examined some of these factors separately to determine their effect on coating residual stresses, but none have examined all the factors concurrently. The purpose of this research, which was performed at DCT, Inc., in contract with the NASA Lewis Research Center, was to develop an inclusive finite element model to characterize the effects of oxidation on the residual stresses within the TBC system during thermal cycling as well as to examine the interaction of oxidation with the other factors affecting TBC life. The plasma sprayed, two-layer thermal barrier coating that was modeled incorporated a superalloy substrate, a NiCrAlY bond coat, and a ZrO2-8 wt % Y2O3 ceramic top coat. We
Manufacturing parabolic mirrors
CERN PhotoLab
1975-01-01
The photo shows the construction of a vertical centrifuge mounted on an air cushion, with a precision of 1/10000 during rotation, used for the manufacture of very high=precision parabolic mirrors. (See Annual Report 1974.)
A two-dimensional parabolic model for vertical annular two-phase flow
Fernandez, F.M.; Toledo, A. Alvarez; Paladino, E.E. [Graduate Program in Mechanical Engineering, Universidade Federal de Rio Grande do Norte, Natal, RN (Brazil)], e-mail: emilio@ct.ufrn.br
2010-07-01
This work presents a solution algorithm for predicting hydrodynamic parameters for developing and equilibrium, adiabatic, annular, vertical two-phase flow. It solves mass and momentum transport differential equations for both the core and the liquid film across their entire domains. Thus, the velocity and shear stress distributions from the tube center to the wall are obtained, together with the average film thickness and the pressure gradient, making no use of empirical closure relations nor assuming any known velocity profile to solve the triangular relationship in the liquid film. The model was developed using the Finite Volume Method and an iterative procedure is proposed to solve all flow variables for given phase superficial velocities. The procedure is validated against the analytical solution for laminar flow and experimental data for gas-liquid turbulent flow with entrainment. For the last case, an algebraic turbulence model is used for turbulent viscosity calculation for both, liquid film and gas core. (author)
Barrier traversal times using a phenomenological track formation model
Palao, J P; Brouard, S; Jadczyk, A
1997-01-01
A phenomenological model for a measurement of barrier traversal times for particles is proposed. Two idealized detectors for passage and arrival provide entrance and exit times for the barrier traversal. The averaged traversal time is computed over the ensemble of particles detected twice, before and after the barrier. The Hartman effect can still be found when passage detectors that conserve the momentum distribution of the incident packet are used.
Unified Model of Dynamic Forced Barrier Crossing in Single Molecules
Friddle, R W
2007-06-21
Thermally activated barrier crossing in the presence of an increasing load can reveal kinetic rate constants and energy barrier parameters when repeated over a range of loading rates. Here we derive a model of the mean escape force for all relevant loading rates--the complete force spectrum. Two well-known approximations emerge as limiting cases; one of which confirms predictions that single-barrier spectra should converge to a phenomenological description in the slow loading limit.
Modelling dune erosion, overwash and inundation of barrier islands
Hoonhout, B.; Thiel de Vries, J.S.M.
2012-01-01
Physical model experiments are performed at Deltares to investigate the morphological response of barrier islands on extreme storm events. The experiments included dune erosion, overwash and inundation regimes. Extensive measurement techniques made detailed comparison with numerical models possible.
Numerical approximation for a degenerate parabolic-elliptic system modeling flows in porous media
Rabah-Hacene Bellout
2012-11-01
Full Text Available We present a numerical scheme for the approximation of the system of partial differential equations of the Peaceman model for the miscible displacement of one fluid by another in a two dimensional porous medium. In this scheme, the velocity-pressure equations are treated by a mixed finite element discretization using the Raviart-Thomas element, and the concentration equation is approximated by a finite volume discretization using the Upstream scheme, knowing that the Raviart-Thomas element gives good approximations for fluids velocities and that the Upstream scheme is well suited for convection dominated equations. We prove a maximum principle for our approximate concentration more precisely $ 0leq c_h(x,tleq 1$ a.e. in $Omega_T $ as long as some grid conditions are satisfied - at the difference of Chainais and Droniou [6]who have only observed that their approximate concentration remains in $[0;1]$ (and such is the case for other proposed numerical methods; e.g., [21,22]. Moreover our grid conditions are satisfied even with very large time steps and spatial steps. Finally we prove the consistency of the proposed scheme and thus are assured of convergence. A numerical test is reported.
Lifetime Modeling of Thermal Barrier Coatings
Hille, T.S.
2009-01-01
Thermal barrier coatings (TBCs) are applied in gas turbines to enhance their thermal efficiency by isolating the metallic components from the aggressive hot gas. TBC lifetime is limited by damage processes originating at internal interfaces, which may ultimately lead to delamination and spallation.
Physical based Schottky barrier diode modeling for THz applications
Yan, Lei; Krozer, Viktor; Michaelsen, Rasmus Schandorph;
2013-01-01
In this work, a physical Schottky barrier diode model is presented. The model is based on physical parameters such as anode area, Ohmic contact area, doping profile from epitaxial (EPI) and substrate (SUB) layers, layer thicknesses, barrier height, specific contact resistance, and device...... temperature. The effects of barrier height lowering, nonlinear resistance from the EPI layer, and hot electron noise are all included for accurate characterization of the Schottky diode. To verify the diode model, measured I-V and C-V characteristics are compared with the simulation results. Due to the lack...
Thermal model of attic systems with radiant barriers
Wilkes, K.E.
1991-07-01
This report summarizes the first phase of a project to model the thermal performance of radiant barriers. The objective of this phase of the project was to develop a refined model for the thermal performance of residential house attics, with and without radiant barriers, and to verify the model by comparing its predictions against selected existing experimental thermal performance data. Models for the thermal performance of attics with and without radiant barriers have been developed and implemented on an IBM PC/AT computer. The validity of the models has been tested by comparing their predictions with ceiling heat fluxes measured in a number of laboratory and field experiments on attics with and without radiant barriers. Cumulative heat flows predicted by the models were usually within about 5 to 10 percent of measured values. In future phases of the project, the models for attic/radiant barrier performance will be coupled with a whole-house model and further comparisons with experimental data will be made. Following this, the models will be utilized to provide an initial assessment of the energy savings potential of radiant barriers in various configurations and under various climatic conditions. 38 refs., 14 figs., 22 tabs.
Barriers to Business Model Innovation in Swedish Agriculture
Olof Sivertsson
2015-02-01
Full Text Available Swedish agricultural companies, especially small farms, are struggling to be profitable in difficult economic times. It is a challenge for Swedish farmers to compete with imported products on prices. The agricultural industry, however, supports the view that through business model innovation, farms can increase their competitive advantage. This paper identifies and describes some of the barriers Swedish small farms encounter when they consider business model innovation. A qualitative approach is used in the study. Agriculture business consultants were interviewed. In a focus group led by the researchers, farmers discussed business model innovation, including the exogenous and endogenous barriers to such innovation. The paper concludes many barriers exist when farmers consider innovation of agricultural business models. Some barriers are caused by human factors, such as individuals’ attitudes, histories, and traditions. Other barriers are more contextual in nature and relate to a particular industry or company setting. Still other barriers, such as government regulations, value chain position, and weather, are more abstract. All barriers, however, merit attention when Swedish agricultural companies develop new business models.
Cabezón D.
2014-01-01
Full Text Available Wake effect represents one of the main sources of energy loss and uncertainty when designing offshore wind farms. Traditionally analytical models have been used to optimize and estimate power deficits. However these models have shown to underestimate wake effect and consequently overestimate output power [1, 2]. This means that analytical models can be very helpful at optimizing preliminary layouts but not as accurate as needed for an ultimate fine design. Different techniques can be found in the literature to study wind turbine wakes that include simplified kinematic models and more advanced field models, that solve flow equations with different turbulence closure schemes. See the review papers of Crespo et al. [3], Vermeer et al. [4], and Sanderse et al. [5]. Purely elliptic Computational Fluid Dynamics (CFD models based on the actuator disk technique have been developed during the last years [6–8]. They consider wind turbine rotor as a disk where a distribution of axial forces act over the incoming air. It is a fair approach but it can still be computationally expensive for big wind farms in an operative mode. With this technique still active, an alternative approach inspired on the parabolic wake models [9, 10] is proposed. Wind turbine rotors continue to be represented as actuator disks but now the domain is split into subdomains containing one or more wind turbines. The output of each subdomain is mapped onto the input boundary of the next one until the end of the domain is reached, getting a considerable decrease on computational time, by a factor of order 10. As the model is based on the open source CFD solver OpenFOAM, it can be parallelized to speed-up convergence. The near wake is calculated so no initial wind speed deficit profiles have to be supposed as in totally parabolic models and alternative turbulence models, such as the anisotropic Reynolds Stress Model (RSM can be used. Traditional problems of elliptic models related to
On the dynamics of a mixed parabolic-gradient system
J.K. Krottje (Johannes)
2002-01-01
textabstractIn the current paper the dynamics of a mixed parabolic-gradient system is examined. Thesystem, which is a coupled system of parabolic equations and gradient equations, acts as a first model for the outgrowth of axons in a developing nervous system. For modeling considerations it is relev
Interaction of tide and salinity barrier: Limitation of numerical model
Suphat Vongvisessomjai1
2008-07-01
Full Text Available Nowadays, the study of interaction of the tide and the salinity barrier in an estuarine area is usually accomplished vianumerical modeling, due to the speed and convenience of modern computers. However, numerical models provide littleinsight with respect to the fundamental physical mechanisms involved. In this study, it is found that all existing numericalmodels work satisfactorily when the barrier is located at some distance far from upstream and downstream boundary conditions.Results are considerably underestimate reality when the barrier is located near the downstream boundary, usually theriver mouth. Meanwhile, this analytical model provides satisfactory output for all scenarios. The main problem of thenumerical model is that the effects of barrier construction in creation of reflected tide are neglected when specifying thedownstream boundary conditions; the use of the boundary condition before construction of the barrier which are significantlydifferent from those after the barrier construction would result in an error outputs. Future numerical models shouldattempt to account for this deficiency; otherwise, using this analytical model is another choice.
Arnulfo Luévanos Rojas
2014-07-01
Full Text Available This paper develops a mathematical model for fixed-end moments for two different types of loads on beams with a parabolic shaped variable rectangular cross section. The loads applied on beam are: 1 a uniformly distributed load and 2 a concentrated load located anywhere along the beam length. The properties of the rectangular cross section of the beam varies along its axis, i.e., the width “b” is constant and the height “h” varies along the beam, this variation follows a parabolic form. The consistent deformation method based on the superposition of the effects is used to solve these problems. The deformation anywhere along the beam is obtained by using the Bernoulli-Euler theory. Traditional methods used to obtain deflections of variable cross section members are any techniques that perform numerical integration, such as Simpson's rule. Tables presented by other authors are restricted to certain relationships. Beyond the effectiveness and accuracy of the developed model, a significant advantage of it is the moments are calculated at any cross section of the beam using the respective integral representations as mathematical formulas.
Mineral resource analysis by parabolic fractals
XIE Shu-yun; YANG Yong-guo; BAO Zheng-yu; KE Xian-zhong; LIU Xiao-long
2009-01-01
Elemental concentration distributions in space have been analyzed using different approaches. These analyses are of great significance for the quantitative characterization of various kinds of distribution patterns. Fractal and multi-fiactal methods have been extensively applied to this topic. Traditionally, approximately linear-fractal laws have been regarded as useful tools for characterizing the self-similarities of element concentrations. But, in nature, it is not always easy to fred perfect linear fractal laws. In this paper the parabolic fractal model is used. First a two dimensional multiplicative multi-fractal cascade model is used to study the concentration patterns. The results show the parabolic fractal (PF) properties of the concentrations and the validity of non-linear fractal analysis. By dividing the studied area into four sub-areas it was possible to show that each part follows a non-linear para-bolic fractal law and that the dispersion within each part varies. The ratio of the polynomial coefficients of the fitted parabolic curves can reflect, to some degree, the relative concentration and dispersal distribution patterns. This can provide new insight into the ore-forming potential in space. The parabolic fractal evaluations of ore-forming potential for the four subareas are in good agreement with field investigation work and geochemical mapping results based on analysis of the original data.
Nonlinear elliptic-parabolic problems
Kim, Inwon C
2012-01-01
We introduce a notion of viscosity solutions for a general class of elliptic-parabolic phase transition problems. These include the Richards equation, which is a classical model in filtration theory. Existence and uniqueness results are proved via the comparison principle. In particular, we show existence and stability properties of maximal and minimal viscosity solutions for a general class of initial data. These results are new even in the linear case, where we also show that viscosity solutions coincide with the regular weak solutions introduced in [Alt&Luckhaus 1983].
Lattice model of reduced jamming by a barrier
Cirillo, Emilio N. M.; Krehel, Oleh; Muntean, Adrian; van Santen, Rutger
2016-10-01
We study an asymmetric simple exclusion process in a strip in the presence of a solid impenetrable barrier. We focus on the effect of the barrier on the residence time of the particles, namely, the typical time needed by the particles to cross the whole strip. We explore the conditions for reduced jamming when varying the environment (different drifts, reservoir densities, horizontal diffusion walks, etc.). In particular, we discover an interesting nonmonotonic behavior of the residence time as a function of the barrier length. Besides recovering by means of both the lattice dynamics and the mean-field model well-known aspects like the faster-is-slower effect and the intermittence of the flow, we propose also a birth-and-death process and a reduced one-dimensional (1D) model with variable barrier permeability to capture the behavior of the residence time with respect to the parameters.
Biswas, Indranil
2011-01-01
We construct projectivization of a parabolic vector bundle and a tautological line bundle over it. It is shown that a parabolic vector bundle is ample if and only if the tautological line bundle is ample. This allows us to generalize the notion of a k-ample bundle, introduced by Sommese, to the context of parabolic bundles. A parabolic vector bundle $E_*$ is defined to be k-ample if the tautological line bundle ${\\mathcal O}_{{\\mathbb P}(E_*)}(1)$ is $k$--ample. We establish some properties of parabolic k-ample bundles.
The Technological Barriers of Using Video Modeling in the Classroom
Marino, Desha; Myck-Wayne, Janice
2015-01-01
The purpose of this investigation is to identify the technological barriers teachers encounter when attempting to implement video modeling in the classroom. Video modeling is an emerging evidence-based intervention method used with individuals with autism. Research has shown the positive effects video modeling can have on its recipients. Educators…
Session: Parabolic Troughs (Presentation)
Kutscher, C.
2008-04-01
The project description is R and D activities at NREL and Sandia aimed at lowering the delivered energy cost of parabolic trough collector systems and FOA awards to support industry in trought development. The primary objectives are: (1) support development of near-term parabolic trought technology for central station power generation; (2) support development of next-generation trought fields; and (3) support expansion of US trough industry. The major FY08 activities were: (1) improving reflector optics; (2) reducing receiver heat loss (including improved receiver coating and mitigating hydrogen accumulation); (3) measuring collector optical efficiency; (4) optimizing plant performance and reducing cost; (5) reducing plant water consumption; and (6) directly supporting industry needs, including FOA support.
Aytuna, Aydin
2011-01-01
An open Riemann surface is called parabolic in case every bounded subharmonic function on it reduces to a constant. Several authors introduced seemingly different analogs of this notion for Stein manifolds of arbitrary dimension. In the first part of this note we compile these notions of parabolicity and give some immediate relations among them. In section 3 we relate some of these notions to the linear topological type of the Fr\\'echet space of analytic functions on the given manifold. In sections 4 and 5 we look at some examples and show, for example, that the complement of the zero set of a Weierstrass polynomial possesses a continuous plurisubharmonic exhaustion function that is maximal off a compact subset.
Mahonians and parabolic quotients
Caselli, Fabrizio
2011-01-01
We study the distribution of the major index with sign on some parabolic quotients of the symmetric group, extending and generalizing simultaneously results of Panova [G. Panova, Bijective enumeration of permutations starting with a longest increasing subsequence, Discrete Math. Theor. Comput. Sci. Proc. AN (2010), 841--850], Gessel-Simion [M. Wachs, An involution for signed Eulerian numbers, Discrete Math. 99 (1992), 59--62] and Adin-Gessel-Roichman [R. Adin, I. Gessel and Y. Roichman, Signed Mahonians, J. Combin. Theory Ser. A 109 (2005), 25--43]. We further consider and compute the distribution of the flag-major index on some parabolic quotients of wreath products and other related groups. All these distributions turn out to have very simple factorization formulas.
Dispersion modelling approaches for near road applications involving noise barriers
The talk will present comparisons with two datasets of the barrier algorithms implemented in two different dispersion models: US EPA’s R-LINE (a research dispersion modelling tool under development by the US EPA’s Office of Research and Development) and CERC’s A...
Optical properties of Dirac electrons in a parabolic well.
Kim, S C; Lee, J W; Yang, S-R Eric
2013-09-01
A single electron transitor may be fabricated using qunatum dots. A good model for the confinement potential of a quantum dot is a parabolic well. Here we consider such a parabolic dot made of graphene. Recently, we found counter intuitively that resonant quasi-boundstates of both positive and negative energies exist in the energy spectrum. The presence of resonant quasi-boundstates of negative energies is a unique property of massless Dirac fermions. As magnetic field B gets smaller the energy width of these states become broader and for sufficiently weak value of B resonant quasi-bound states disappear into a quasi-continuum. In the limit of small B resonant and nonresonant states transform into discrete anomalous states with a narrow probability density peak inside the well and another broad peak under the potential barrier. In this paper we compute the optical strength between resonant quasi-bound states as a function of B, and investigate how the signature of resonant quasi-bound states of Dirac electrons may appear in optical measurements.
基于槽式集热器中抛物线的量化分析模型%Quantized analysis models for parabola of parabolic trough collector
余雷; 王军; 张耀明
2011-01-01
A series of models for parabola of solar parabolic trough collector with tubular receiver were built based on cone optics method and sun shape model, such as optical concentration ratio,optical efficiency, coefficient of error, consumption of reflector materials and radius of curvature.The results show that the maximum critical concentration ratio is 68.45, the maximum theoretical concentration ratio is 215. Compared with traditional collectors, the error factor of new collector reduces by 8.2％, the length factor increases by 16. 8％, the curvature factor reduces by 10. 6％.These models can by the guidance for selecting the parabola for a solar parabolic trough collector.%针对带有管状接收器的槽式集热装置中所采用的抛物线,运用锥体光学法结合太阳形状模型对选择抛物线所需考虑的光学聚光比、光学利用率、误差造成影响的程度、所需镜面的材料以及镜面所承受的最大曲率等方面进行研究.结果表明:临界聚光比最大值为68.45;聚光比的理论最大值为215;所设计的集热器相对于传统集热器误差影响系数降低8.2%,曲面长度系数增加16.8%,曲率半径系数降低10.6%;所建立的模型可指导实际设计中选择合适的抛物线方程.
Muir, J.F.; Hogan, R.E. Jr.; Skocypec, R.D. [Sandia National Labs., Albuquerque, NM (US); Buck, R. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt, Stuttgart (DE). Inst. of Technical Thermodynamics
1993-07-01
A joint US/Federal Republic of Germany (FRG) project has successfully tested a unique solar-driven chemical reactor in the CAtalytically Enhanced Solar Absorption Receiver (CAESAR) experiment. The CAESAR test was a {open_quotes}proof-of-concept{close_quotes} demonstration of carbon-dioxide reforming of methane in a commercial-scale, solar, volumetric receiver/reactor on a parabolic dish concentrator. The CAESAR design; test facility and instrumentation; thermal and chemical tests; and analysis of test results are presented in detail. Numerical models for the absorber and the receiver are developed and predicted performance is compared with test data. Post test analyses to assess the structural condition of the absorber and the effectiveness of the rhodium catalyst are presented. Unresolved technical issues are identified and future development efforts are recommended.
Engineered Barrier System: Physical and Chemical Environment Model
D. M. Jolley; R. Jarek; P. Mariner
2004-02-09
The conceptual and predictive models documented in this Engineered Barrier System: Physical and Chemical Environment Model report describe the evolution of the physical and chemical conditions within the waste emplacement drifts of the repository. The modeling approaches and model output data will be used in the total system performance assessment (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. These models evaluate the range of potential water compositions within the emplacement drifts, resulting from the interaction of introduced materials and minerals in dust with water seeping into the drifts and with aqueous solutions forming by deliquescence of dust (as influenced by atmospheric conditions), and from thermal-hydrological-chemical (THC) processes in the drift. These models also consider the uncertainty and variability in water chemistry inside the drift and the compositions of introduced materials within the drift. This report develops and documents a set of process- and abstraction-level models that constitute the engineered barrier system: physical and chemical environment model. Where possible, these models use information directly from other process model reports as input, which promotes integration among process models used for total system performance assessment. Specific tasks and activities of modeling the physical and chemical environment are included in the technical work plan ''Technical Work Plan for: In-Drift Geochemistry Modeling'' (BSC 2004 [DIRS 166519]). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system analysis model reports.
Courant Algebroids in Parabolic Geometry
Armstrong, Stuart
2011-01-01
To a smooth manifold $M$, a parabolic geometry associates a principal bundle, which has a parabolic subgroup of a semisimple Lie group as its structure group, and a Cartan connection. We show that the adjoint tractor bundle of a regular normal parabolic geometry can be endowed with the structure of a Courant algebroid. This gives a class of examples of transitive Courant algebroids that are not exact.
Radiative Transport Modelling of Thermal Barrier Coatings
2017-03-24
traveled by signal and reference beam photons) is the result of signal photons travelling a distance L through the sample . Since this distance L is related...performed in both tasks together for convenience . First, we briefly discuss the random walk model, since it is relevant in the discussion on both the...Figure 7, whereby a collinear low coherence beam (shown as a red arrow) is considered to be incident onto the sample at normal incidence to the surface
QSAR model for blood-brain barrier permeation.
Toropov, Andrey A; Toropova, Alla P; Beeg, Marten; Gobbi, Marco; Salmona, Mario
2017-05-02
Predicting blood-brain barrier permeability for novel compounds is an important goal for neurotherapeutics-focused drug discovery. It is impossible to determine experimentally the blood-brain barrier partitioning of all possible candidates. Consequently, alternative evaluation methods based on computational models are desirable or even necessary. The CORAL software (http://www.insilico.eu/coral) has been checked up as a tool to build up quantitative structure - activity relationships for blood-brain barrier permeation. The Monte Carlo technique gives possibility to build up predictive model of an endpoint by means of selection of so-called correlation weights of various molecular features. Descriptors calculated with these weights are basis for correlations "structure-endpoint". The approach gives good models for three random splits into the training and validation sets. The best model characterized by the following statistics for the external validation set: the number of compounds is 41, determination coefficient is equal to 0.896, root mean squared error is equal to 0.175. The suggested approach can be applied as a tool for prediction of blood-brain barrier permeation. Copyright © 2017 Elsevier Inc. All rights reserved.
Modelling with uncertainties: The role of the fission barrier
Lü Hongliang
2013-12-01
Full Text Available Fission is the dominant decay channel of super-heavy elements formed in heavy ions collisions. The probability of synthesizing heavy or super-heavy nuclei in fusion-evaporation reactions is then very sensitive to the height of their fission barriers. This contribution will firstly address the influence of theoretical uncertainty on excitation functions. Our second aim is to investigate the inverse problem, i.e., what information about the fission barriers can be extracted from excitation functions? For this purpose, Bayesian methods have been used with a simplified toy model.
Engineered Barrier System Degradation, Flow, and Transport Process Model Report
E.L. Hardin
2000-07-17
The Engineered Barrier System Degradation, Flow, and Transport Process Model Report (EBS PMR) is one of nine PMRs supporting the Total System Performance Assessment (TSPA) being developed by the Yucca Mountain Project for the Site Recommendation Report (SRR). The EBS PMR summarizes the development and abstraction of models for processes that govern the evolution of conditions within the emplacement drifts of a potential high-level nuclear waste repository at Yucca Mountain, Nye County, Nevada. Details of these individual models are documented in 23 supporting Analysis/Model Reports (AMRs). Nineteen of these AMRs are for process models, and the remaining 4 describe the abstraction of results for application in TSPA. The process models themselves cluster around four major topics: ''Water Distribution and Removal Model, Physical and Chemical Environment Model, Radionuclide Transport Model, and Multiscale Thermohydrologic Model''. One AMR (Engineered Barrier System-Features, Events, and Processes/Degradation Modes Analysis) summarizes the formal screening analysis used to select the Features, Events, and Processes (FEPs) included in TSPA and those excluded from further consideration. Performance of a potential Yucca Mountain high-level radioactive waste repository depends on both the natural barrier system (NBS) and the engineered barrier system (EBS) and on their interactions. Although the waste packages are generally considered as components of the EBS, the EBS as defined in the EBS PMR includes all engineered components outside the waste packages. The principal function of the EBS is to complement the geologic system in limiting the amount of water contacting nuclear waste. A number of alternatives were considered by the Project for different EBS designs that could provide better performance than the design analyzed for the Viability Assessment. The design concept selected was Enhanced Design Alternative II (EDA II).
HIV-1 Nef breaches placental barrier in rat model.
Singh, Poonam; Agnihotri, Saurabh Kumar; Tewari, Mahesh Chandra; Kumar, Sadan; Sachdev, Monika; Tripathi, Raj Kamal
2012-01-01
The vertical transmission of HIV-1 from the mother to fetus is known, but the molecular mechanism regulating this transmission is not fully characterized. The fetus is highly protected by the placenta, which does not permit microbial pathogens to cross the placental barrier. In the present study, a rat model was established to observe the effect of HIV-1 protein Nef on placental barrier. Evans blue dye was used to assay permeability of placental barrier and fourteen day pregnant Sprague Dawley rats were injected intravenously with 2% Evans blue dye along with various concentrations of recombinant Nef. After an hour, animals were sacrificed and dye migration was observed through the assimilation of peripheral blood into fetus. Interestingly, traces of recombinant Nef protein were detected in the embryo as well as amniotic fluid and amniotic membrane along with placenta and uterus. Our study indicates that recombinant HIV-1-Nef protein breaches the placental barrier and allows the migration of Evans blue dye to the growing fetus. Further the concentration of Nef protein in blood is directly proportional to the intensity of dye migration and to the amount of Nef protein detected in uterus, placenta, amniotic membrane, amniotic fluid and embryo. Based on this study, it can be concluded that the HIV-1 Nef protein has a direct effect on breaching of the placental barrier in the model we have established in this study. Our observations will be helpful to understand the molecular mechanisms related to this breach of placental barrier by Nef in humans and may be helpful to identify specific Nef inhibitors.
The mass and temperature functions in a moving barrier model
Popolo, A D
2002-01-01
In this paper, I use the extension of the excursion set model of Sheth & Tormen (2002) and the barrier shape obtained in Del Popolo & Gambera (1998) to calculate the unconditional halo mass function, and the conditional mass function in several cosmological models. I show that the barrier obtained in Del Popolo & Gambera (1998), which takes account of tidal interaction between proto-haloes, is a better description of the mass functions than the spherical collapse and is in good agreement with numerical simulations (Tozzi & Governato 1998, and Governato et al. 1999). The results are also in good agreement with those obtained by Sheth & Tormen (2002), only slight differences are observed expecially at the low mass end. I moreover calculate, and compare with simulations, the temperature function obtained by means of the mass functions previously calculated and also using an improved version of the M-T relation, which accounts for the fact that massive clusters accrete matter quasi-continuousl...
A microphysiological model of the human placental barrier.
Blundell, Cassidy; Tess, Emily R; Schanzer, Ariana S R; Coutifaris, Christos; Su, Emily J; Parry, Samuel; Huh, Dongeun
2016-08-02
During human pregnancy, the fetal circulation is separated from maternal blood in the placenta by two cell layers - the fetal capillary endothelium and placental trophoblast. This placental barrier plays an essential role in fetal development and health by tightly regulating the exchange of endogenous and exogenous materials between the mother and the fetus. Here we present a microengineered device that provides a novel platform to mimic the structural and functional complexity of this specialized tissue in vitro. Our model is created in a multilayered microfluidic system that enables co-culture of human trophoblast cells and human fetal endothelial cells in a physiologically relevant spatial arrangement to replicate the characteristic architecture of the human placental barrier. We have engineered this co-culture model to induce progressive fusion of trophoblast cells and to form a syncytialized epithelium that resembles the syncytiotrophoblast in vivo. Our system also allows the cultured trophoblasts to form dense microvilli under dynamic flow conditions and to reconstitute expression and physiological localization of membrane transport proteins, such as glucose transporters (GLUTs), critical to the barrier function of the placenta. To provide a proof-of-principle for using this microdevice to recapitulate native function of the placental barrier, we demonstrated physiological transport of glucose across the microengineered maternal-fetal interface. Importantly, the rate of maternal-to-fetal glucose transfer in this system closely approximated that measured in ex vivo perfused human placentas. Our "placenta-on-a-chip" platform represents an important advance in the development of new technologies to model and study the physiological complexity of the human placenta for a wide variety of applications.
Mathematical modelling of blood-brain barrier failure and edema
Waters, Sarah; Lang, Georgina; Vella, Dominic; Goriely, Alain
2015-11-01
Injuries such as traumatic brain injury and stroke can result in increased blood-brain barrier permeability. This increase may lead to water accumulation in the brain tissue resulting in vasogenic edema. Although the initial injury may be localised, the resulting edema causes mechanical damage and compression of the vasculature beyond the original injury site. We employ a biphasic mixture model to investigate the consequences of blood-brain barrier permeability changes within a region of brain tissue and the onset of vasogenic edema. We find that such localised changes can indeed result in brain tissue swelling and that the type of damage that results (stress damage or strain damage) depends on the ability of the brain to clear edema fluid.
A conceptual model for barrier free facilities planning.
Bittencourt, R S; de M Guimarães, L B
2012-01-01
This paper presents the proposal of a model for planning a barrier free industrial facilities, considering the demands that inclusion requires, ranging from outside the factory (social environment), to the needs of the production system and the workstation. Along with literature review, the demands were identified in a shoe manufacturer that employs people with disabilities, and organized taxonomically in agreement with the structure for planning facilities. The results show that the problems are not primarily related to eliminating architectural barriers and factors aimed at preventing risks to people's health and safety but, rather, are related to the company's cultural environment, because the main hazards are managerial. In special cases, it is suggested there is a need to adjust those parts of tasks that the worker cannot do, or even to re-schedule work so as to make it possible for employees with disabilities to perform their tasks.
Study on a Cross Diffusion Parabolic System
Li Chen; Ling Hsiao; Gerald Warnecke
2007-01-01
This paper considers a kind of strongly coupled cross diffusion parabolic system, which can be used as the multi-dimensional Lyumkis energy transport model in semiconductor science. The global existence and large time behavior are obtained for smooth solution to the initial boundary value problem. When the initial data are a small perturbation of an isothermal stationary solution, the smooth solution of the problem under the insulating boundary condition, converges to that stationary solution exponentially fast as time goes to infinity.
Commercialization of parabolic dish systems
Washom, B.
1982-01-01
The impact of recent federal tax and regulatory legislation on the commercialization of parabolic solar reflector technology is assessed. Specific areas in need of technical or economic improvement are noted.
Invariant foliations for parabolic equations
无
2000-01-01
It is proved for parabolic equations that under certain conditions the weak (un-)stable manifolds possess invariant foliations, called strongly (un-)stable foliations. The relevant results on center manifolds are generalized to weak hyperbolic manifolds.
The planar parabolic optical antenna.
Schoen, David T; Coenen, Toon; García de Abajo, F Javier; Brongersma, Mark L; Polman, Albert
2013-01-09
One of the simplest and most common structures used for directing light in macroscale applications is the parabolic reflector. Parabolic reflectors are ubiquitous in many technologies, from satellite dishes to hand-held flashlights. Today, there is a growing interest in the use of ultracompact metallic structures for manipulating light on the wavelength scale. Significant progress has been made in scaling radiowave antennas to the nanoscale for operation in the visible range, but similar scaling of parabolic reflectors employing ray-optics concepts has not yet been accomplished because of the difficulty in fabricating nanoscale three-dimensional surfaces. Here, we demonstrate that plasmon physics can be employed to realize a resonant elliptical cavity functioning as an essentially planar nanometallic structure that serves as a broadband unidirectional parabolic antenna at optical frequencies.
Parabolic sheaves on logarithmic schemes
Borne, Niels; Vistoli, Angelo
2010-01-01
We show how the natural context for the definition of parabolic sheaves on a scheme is that of logarithmic geometry. The key point is a reformulation of the concept of logarithmic structure in the language of symmetric monoidal categories, which might be of independent interest. Our main result states that parabolic sheaves can be interpreted as quasi-coherent sheaves on certain stacks of roots.
Parabolic metamaterials and Dirac bridges
Colquitt, D. J.; Movchan, N. V.; Movchan, A. B.
2016-10-01
A new class of multi-scale structures, referred to as `parabolic metamaterials' is introduced and studied in this paper. For an elastic two-dimensional triangular lattice, we identify dynamic regimes, which corresponds to so-called `Dirac Bridges' on the dispersion surfaces. Such regimes lead to a highly localised and focussed unidirectional beam when the lattice is excited. We also show that the flexural rigidities of elastic ligaments are essential in establishing the `parabolic metamaterial' regimes.
Mechatronic Prototype of Parabolic Solar Tracker.
Morón, Carlos; Díaz, Jorge Pablo; Ferrández, Daniel; Ramos, Mari Paz
2016-06-15
In the last 30 years numerous attempts have been made to improve the efficiency of the parabolic collectors in the electric power production, although most of the studies have focused on the industrial production of thermoelectric power. This research focuses on the application of this concentrating solar thermal power in the unexplored field of building construction. To that end, a mechatronic prototype of a hybrid paraboloidal and cylindrical-parabolic tracker based on the Arduido technology has been designed. The prototype is able to measure meteorological data autonomously in order to quantify the energy potential of any location. In this way, it is possible to reliably model real commercial equipment behavior before its deployment in buildings and single family houses.
Mechatronic Prototype of Parabolic Solar Tracker
Carlos Morón
2016-06-01
Full Text Available In the last 30 years numerous attempts have been made to improve the efficiency of the parabolic collectors in the electric power production, although most of the studies have focused on the industrial production of thermoelectric power. This research focuses on the application of this concentrating solar thermal power in the unexplored field of building construction. To that end, a mechatronic prototype of a hybrid paraboloidal and cylindrical-parabolic tracker based on the Arduido technology has been designed. The prototype is able to measure meteorological data autonomously in order to quantify the energy potential of any location. In this way, it is possible to reliably model real commercial equipment behavior before its deployment in buildings and single family houses.
Parabolic aircraft solidification experiments
Workman, Gary L. (Principal Investigator); Smith, Guy A.; OBrien, Susan
1996-01-01
A number of solidification experiments have been utilized throughout the Materials Processing in Space Program to provide an experimental environment which minimizes variables in solidification experiments. Two techniques of interest are directional solidification and isothermal casting. Because of the wide-spread use of these experimental techniques in space-based research, several MSAD experiments have been manifested for space flight. In addition to the microstructural analysis for interpretation of the experimental results from previous work with parabolic flights, it has become apparent that a better understanding of the phenomena occurring during solidification can be better understood if direct visualization of the solidification interface were possible. Our university has performed in several experimental studies such as this in recent years. The most recent was in visualizing the effect of convective flow phenomena on the KC-135 and prior to that were several successive contracts to perform directional solidification and isothermal casting experiments on the KC-135. Included in this work was the modification and utilization of the Convective Flow Analyzer (CFA), the Aircraft Isothermal Casting Furnace (ICF), and the Three-Zone Directional Solidification Furnace. These studies have contributed heavily to the mission of the Microgravity Science and Applications' Materials Science Program.
Lin, Ying-Tsong; Collis, Jon M; Duda, Timothy F
2012-11-01
An alternating direction implicit (ADI) three-dimensional fluid parabolic equation solution method with enhanced accuracy is presented. The method uses a square-root Helmholtz operator splitting algorithm that retains cross-multiplied operator terms that have been previously neglected. With these higher-order cross terms, the valid angular range of the parabolic equation solution is improved. The method is tested for accuracy against an image solution in an idealized wedge problem. Computational efficiency improvements resulting from the ADI discretization are also discussed.
Energy barriers, entropy barriers, and non-Arrhenius behavior in a minimal glassy model.
Du, Xin; Weeks, Eric R
2016-06-01
We study glassy dynamics using a simulation of three soft Brownian particles confined to a two-dimensional circular region. If the circular region is large, the disks freely rearrange, but rearrangements are rarer for smaller system sizes. We directly measure a one-dimensional free-energy landscape characterizing the dynamics. This landscape has two local minima corresponding to the two distinct disk configurations, separated by a free-energy barrier that governs the rearrangement rate. We study several different interaction potentials and demonstrate that the free-energy barrier is composed of a potential-energy barrier and an entropic barrier. The heights of both of these barriers depend on temperature and system size, demonstrating how non-Arrhenius behavior can arise close to the glass transition.
Application of the New Weiland Model for Studying Transport Barriers
Kritz, Arnold; Fan, Xiang; Rafiq, Tariq; Tangri, Varun; Pankin, Alexei; Weiland, Jan
2012-10-01
Recent advances in the Weiland drift wave model include new correlation length and new kink (peeling) terms as well as collisions on free electrons. The new model also includes electromagnetic effects on toroidal and poloidal momentum transport. These advances make the model suitable for simulating anomalous effects in transport barriers. A description of the Weiland model content is included in the adjacent poster by T. Rafiq et al. In this study, particle, thermal, and momentum transport coefficients are computed in systematic scans over electron and ion temperature gradients, temperature ratio, density gradient, magnetic q, collision frequency, trapped particle fraction, magnetic shear, Larmor radius, plasma β and elongation. Special consideration is given to the plasma parameter scans that correspond to the plasma edge region such as large temperature and density gradients, large magnetic shear and large magnetic q. The transport results yielded by the new Weiland drift wave model are contrasted with the earlier version of the model. Combined with high fidelity models for neoclassical effects such as NEO and XGC0 models, it is anticipated that the new Weiland model can be used to model H-mode pedestal buildup and recovery between ELM crashes.
A neurovascular blood-brain barrier in vitro model.
Zehendner, Christoph M; White, Robin; Hedrich, Jana; Luhmann, Heiko J
2014-01-01
The cerebral microvasculature possesses certain cellular features that constitute the blood-brain barrier (BBB) (Abbott et al., Neurobiol Dis 37:13-25, 2010). This dynamic barrier separates the brain parenchyma from peripheral blood flow and is of tremendous clinical importance: for example, BBB breakdown as in stroke is associated with the development of brain edema (Rosenberg and Yang, Neurosurg Focus 22:E4, 2007), inflammation (Kuhlmann et al., Neurosci Lett 449:168-172, 2009; Coisne and Engelhardt, Antioxid Redox Signal 15:1285-1303, 2011), and increased mortality. In vivo, the BBB consists of brain endothelial cells (BEC) that are embedded within a precisely regulated environment containing astrocytes, pericytes, smooth muscle cells, and glial cells. These cells experience modulation by various pathways of intercellular communication and by pathophysiological processes, e.g., through neurovascular coupling (Attwell et al., Nature 468:232-243, 2010), cortical spreading depression (Gursoy-Ozdemir et al., J Clin Invest 113:1447-1455, 2004), or formation of oxidative stress (Yemisci et al., Nat Med 15:1031-1037, 2009). Hence, this interdependent assembly of cells is referred to as the neurovascular unit (NVU) (Zlokovic, Nat Med 16:1370-1371, 2010; Zlokovic, Neuron 57:178-201, 2008). Experimental approaches to investigate the BBB in vitro are highly desirable to study the cerebral endothelium in health and disease. However, due to the complex interactions taking place within the NVU in vivo, it is difficult to mimic this interplay in vitro.Here, we describe a murine blood-brain barrier coculture model consisting of cortical organotypic slice cultures and brain endothelial cells that includes most of the cellular components of the NVU including neurons, astrocytes, and brain endothelial cells. This model allows the experimental analysis of several crucial BBB parameters such as transendothelial electrical resistance or tight junction protein localization by
Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges
Courtney M. Sakolish
2016-03-01
Full Text Available Organ-on-a-chip devices have gained attention in the field of in vitro modeling due to their superior ability in recapitulating tissue environments compared to traditional multiwell methods. These constructed growth environments support tissue differentiation and mimic tissue–tissue, tissue–liquid, and tissue–air interfaces in a variety of conditions. By closely simulating the in vivo biochemical and biomechanical environment, it is possible to study human physiology in an organ-specific context and create more accurate models of healthy and diseased tissues, allowing for observations in disease progression and treatment. These chip devices have the ability to help direct, and perhaps in the distant future even replace animal-based drug efficacy and toxicity studies, which have questionable relevance to human physiology. Here, we review recent developments in the in vitro modeling of barrier tissue interfaces with a focus on the use of novel and complex microfluidic device platforms.
Simulation of parabolic reflectors for ultraviolet phototherapy
Grimes, David Robert
2016-08-01
Ultraviolet (UVR) phototherapy is widely used to treat an array of skin conditions, including psoriasis, eczema and vitiligo. For such interventions, a quantified dose is vital if the treatment is to be both biologically effective and to avoid the detrimental effects of over-dosing. As dose is absorbed at surface level, the orientation of patient site with respect to the UVR lamps modulates effective dose. Previous investigations have modelled this behaviour, and examined the impact of shaped anodized aluminium reflectors typically placed around lamps in phototherapy cabins. These mirrors are effective but tend to yield complex patterns of reflection around the cabin which can result in substantial dose inhomogeneity. There has been some speculation over whether using the reflective property of parabolic mirrors might improve dose delivery or homogeneity through the treatment cabin. In this work, the effects of parabolic mirrors are simulated and compared with standard shaped mirrors. Simulation results strongly suggest that parabolic reflectors reduce total irradiance relative to standard shaped reflectors, and have a negligible impact on dose homogeneity.
Simulation of parabolic reflectors for ultraviolet phototherapy.
Robert Grimes, David
2016-08-21
Ultraviolet (UVR) phototherapy is widely used to treat an array of skin conditions, including psoriasis, eczema and vitiligo. For such interventions, a quantified dose is vital if the treatment is to be both biologically effective and to avoid the detrimental effects of over-dosing. As dose is absorbed at surface level, the orientation of patient site with respect to the UVR lamps modulates effective dose. Previous investigations have modelled this behaviour, and examined the impact of shaped anodized aluminium reflectors typically placed around lamps in phototherapy cabins. These mirrors are effective but tend to yield complex patterns of reflection around the cabin which can result in substantial dose inhomogeneity. There has been some speculation over whether using the reflective property of parabolic mirrors might improve dose delivery or homogeneity through the treatment cabin. In this work, the effects of parabolic mirrors are simulated and compared with standard shaped mirrors. Simulation results strongly suggest that parabolic reflectors reduce total irradiance relative to standard shaped reflectors, and have a negligible impact on dose homogeneity.
Thermal Residual Stress in Environmental Barrier Coated Silicon Nitride - Modeled
Ali, Abdul-Aziz; Bhatt, Ramakrishna T.
2009-01-01
When exposed to combustion environments containing moisture both un-reinforced and fiber reinforced silicon based ceramic materials tend to undergo surface recession. To avoid surface recession environmental barrier coating systems are required. However, due to differences in the elastic and thermal properties of the substrate and the environmental barrier coating, thermal residual stresses can be generated in the coated substrate. Depending on their magnitude and nature thermal residual stresses can have significant influence on the strength and fracture behavior of coated substrates. To determine the maximum residual stresses developed during deposition of the coatings, a finite element model (FEM) was developed. Using this model, the thermal residual stresses were predicted in silicon nitride substrates coated with three environmental coating systems namely barium strontium aluminum silicate (BSAS), rare earth mono silicate (REMS) and earth mono di-silicate (REDS). A parametric study was also conducted to determine the influence of coating layer thickness and material parameters on thermal residual stress. Results indicate that z-direction stresses in all three systems are small and negligible, but maximum in-plane stresses can be significant depending on the composition of the constituent layer and the distance from the substrate. The BSAS and REDS systems show much lower thermal residual stresses than REMS system. Parametric analysis indicates that in each system, the thermal residual stresses can be decreased with decreasing the modulus and thickness of the coating.
Engineering parabolic beams with dynamic intensity profiles.
Ruelas, Adrian; Lopez-Aguayo, Servando; Gutiérrez-Vega, Julio C
2013-08-01
We present optical fields formed by superposing nondiffracting parabolic beams with distinct longitudinal wave-vector components, generating light profiles that display intensity fluxes following parabolic paths in the transverse plane. Their propagation dynamics vary depending on the physical mechanism originating interference, where the possibilities include constructive and destructive interference between traveling parabolic beams, interference between stationary parabolic modes, and combinations of these. The dark parabolic region exhibited by parabolic beams permits a straightforward superposition of intensity fluxes, allowing formation of a variety of profiles, which can exhibit circular, elliptic, and other symmetries.
Electrical model of dielectric barrier discharge homogenous and filamentary modes
López-Fernandez, J. A.; Peña-Eguiluz, R.; López-Callejas, R.; Mercado-Cabrera, A.; Valencia-Alvarado, R.; Muñoz-Castro, A.; Rodríguez-Méndez, B. G.
2017-01-01
This work proposes an electrical model that combines homogeneous and filamentary modes of an atmospheric pressure dielectric barrier discharge cell. A voltage controlled electric current source has been utilized to implement the power law equation that represents the homogeneous discharge mode, which starts when the gas breakdown voltage is reached. The filamentary mode implies the emergence of electric current conducting channels (microdischarges), to add this phenomenon an RC circuit commutated by an ideal switch has been proposed. The switch activation occurs at a higher voltage level than the gas breakdown voltage because it is necessary to impose a huge electric field that contributes to the appearance of streamers. The model allows the estimation of several electric parameters inside the reactor that cannot be measured. Also, it is possible to appreciate the modes of the DBD depending on the applied voltage magnitude. Finally, it has been recognized a good agreement between simulation outcomes and experimental results.
U.S. Geological Survey, Department of the Interior — The Barrier Island and Estuarine Wetland Physical Change Assessment was created to calibrate and test probability models of barrier island estuarine shoreline...
Using models to interpret the impact of roadside barriers on near-road air quality
Amini, Seyedmorteza; Ahangar, Faraz Enayati; Schulte, Nico; Venkatram, Akula
2016-08-01
The question this paper addresses is whether semi-empirical dispersion models based on data from controlled wind tunnel and tracer experiments can describe data collected downwind of a sound barrier next to a real-world urban highway. Both models are based on the mixed wake model described in Schulte et al. (2014). The first neglects the effects of stability on dispersion, and the second accounts for reduced entrainment into the wake of the barrier under unstable conditions. The models were evaluated with data collected downwind of a kilometer-long barrier next to the I-215 freeway running next to the University of California campus in Riverside. The data included measurements of 1) ultrafine particle (UFP) concentrations at several distances from the barrier, 2) micrometeorological variables upwind and downwind of the barrier, and 3) traffic flow separated by automobiles and trucks. Because the emission factor for UFP is highly uncertain, we treated it as a model parameter whose value is obtained by fitting model estimates to observations of UFP concentrations measured at distances where the barrier impact is not dominant. Both models provide adequate descriptions of both the magnitude and the spatial variation of observed concentrations. The good performance of the models reinforces the conclusion from Schulte et al. (2014) that the presence of the barrier is equivalent to shifting the line sources on the road upwind by a distance of about HU/u∗ where H is the barrier height, U is the wind velocity at half of the barrier height, and u∗ is the friction velocity. The models predict that a 4 m barrier results in a 35% reduction in average concentration within 40 m (10 times the barrier height) of the barrier, relative to the no-barrier site. This concentration reduction is 55% if the barrier height is doubled.
Zhu, Dong; Jensen, Leif Bjørnø
2000-01-01
-dimensional, single scattering approach. A periodic sidewall boundary condition is applied for computations in a 360-degree sector, while an approximate sidewall boundary condition is used for calculation in a sector less than 360 degrees. These two sidewall boundary conditions are verified by the numerical results....... The major drawback of using the cylindrical coordinate system, when the backscattering solution is valid within a limited area, is analyzed using a geometrical-optical interpretation. The model may be useful for studying three-dimensional backscattering phenomena comprising azimuthal diffraction effects...
Shenandoah parabolic dish solar collector
Kinoshita, G.S.
1985-01-01
The objectives of the Shenandoah, Georgia, Solar Total Energy System are to design, construct, test, and operate a solar energy system to obtain experience with large-scale hardware systems for future applications. This report describes the initial design and testing activities conducted to select and develop a collector that would serve the need of such a solar total energy system. The parabolic dish was selected as the collector most likely to maximize energy collection as required by this specific site. The fabrication, testing, and installation of the parabolic dish collector incorporating improvements identified during the development testing phase are described.
Shenandoah parabolic dish solar collector
Kinoshita, G.S.
1985-01-01
The objectives of the Shenandoah, Georgia, Solar Total Energy System are to design, construct, test, and operate a solar energy system to obtain experience with large-scale hardware systems for future applications. This report describes the initial design and testing activities conducted to select and develop a collector that would serve the need of such a solar total energy system. The parabolic dish was selected as the collector most likely to maximize energy collection as required by this specific site. The fabrication, testing, and installation of the parabolic dish collector incorporating improvements identified during the development testing phase are described.
OPTIMAL CONTROL PROBLEM FOR PARABOLIC VARIATIONAL INEQUALITIES
汪更生
2001-01-01
This paper deals with the optimal control problems of systems governed by a parabolic variational inequality coupled with a semilinear parabolic differential equations.The maximum principle and some kind of approximate controllability are studied.
Long-Term Morphological Modeling of Barrier Island Tidal Inlets
Richard Styles
2016-09-01
Full Text Available The primary focus of this study is to apply a two-dimensional (2-D coupled flow-wave-sediment modeling system to simulate the development and growth of idealized barrier island tidal inlets. The idealized systems are drawn from nine U.S. coastal inlets representing Pacific Coast, Gulf Coast and Atlantic Coast geographical and climatological environments. A morphological factor is used to effectively model 100 years of inlet evolution and the resulting morphological state is gauged in terms of the driving hydrodynamic processes. Overall, the model performs within the range of established theoretically predicted inlet cross-sectional area. The model compares favorably to theoretical models of maximum inlet currents, which serve as a measure of inlet stability. Major morphological differences are linked to inlet geometry and tidal forcing. Narrower inlets develop channels that are more aligned with the inlet axis while wider inlets develop channels that appear as immature braided channel networks similar to tidal flats in regions with abundant sediment supply. Ebb shoals with strong tidal forcing extend further from shore and spread laterally, promoting multi-lobe development bisected by ebb shoal channels. Ebb shoals with moderate tidal forcing form crescent bars bracketing a single shore-normal channel. Longshore transport contributes to ebb shoal asymmetry and provides bed material to help maintain the sediment balance in the bay.
Performance Simulation Comparison for Parabolic Trough Solar Collectors in China
Jinping Wang
2016-01-01
Full Text Available Parabolic trough systems are the most used concentrated solar power technology. The operating performance and optical efficiency of the parabolic trough solar collectors (PTCs are different in different regions and different seasons. To determine the optimum design and operation of the parabolic trough solar collector throughout the year, an accurate estimation of the daily performance is needed. In this study, a mathematical model for the optical efficiency of the parabolic trough solar collector was established and three typical regions of solar thermal utilization in China were selected. The performance characteristics of cosine effect, shadowing effect, end loss effect, and optical efficiency were calculated and simulated during a whole year in these three areas by using the mathematical model. The simulation results show that the optical efficiency of PTCs changes from 0.4 to 0.8 in a whole year. The highest optical efficiency of PTCs is in June and the lowest is in December. The optical efficiency of PTCs is mainly influenced by the solar incidence angle. The model is validated by comparing the test results in parabolic trough power plant, with relative error range of 1% to about 5%.
Non-Parabolic Hydrodynamic Formulations for the Simulation of Inhomogeneous Semiconductor Devices
Smith, A. W.; Brennan, K. F.
1996-01-01
Hydrodynamic models are becoming prevalent design tools for small scale devices and other devices in which high energy effects can dominate transport. Most current hydrodynamic models use a parabolic band approximation to obtain fairly simple conservation equations. Interest in accounting for band structure effects in hydrodynamic device simulation has begun to grow since parabolic models cannot fully describe the transport in state of the art devices due to the distribution populating non-parabolic states within the band. This paper presents two different non-parabolic formulations or the hydrodynamic model suitable for the simulation of inhomogeneous semiconductor devices. The first formulation uses the Kane dispersion relationship ((hk)(exp 2)/2m = W(1 + alphaW). The second formulation makes use of a power law ((hk)(exp 2)/2m = xW(exp y)) for the dispersion relation. Hydrodynamic models which use the first formulation rely on the binomial expansion to obtain moment equations with closed form coefficients. This limits the energy range over which the model is valid. The power law formulation readily produces closed form coefficients similar to those obtained using the parabolic band approximation. However, the fitting parameters (x,y) are only valid over a limited energy range. The physical significance of the band non-parabolicity is discussed as well as the advantages/disadvantages and approximations of the two non-parabolic models. A companion paper describes device simulations based on the three dispersion relationships; parabolic, Kane dispersion and power law dispersion.
Non-Parabolic Hydrodynamic Formulations for the Simulation of Inhomogeneous Semiconductor Devices
Smith, A. W.; Brennan, K. F.
1996-01-01
Hydrodynamic models are becoming prevalent design tools for small scale devices and other devices in which high energy effects can dominate transport. Most current hydrodynamic models use a parabolic band approximation to obtain fairly simple conservation equations. Interest in accounting for band structure effects in hydrodynamic device simulation has begun to grow since parabolic models cannot fully describe the transport in state of the art devices due to the distribution populating non-parabolic states within the band. This paper presents two different non-parabolic formulations or the hydrodynamic model suitable for the simulation of inhomogeneous semiconductor devices. The first formulation uses the Kane dispersion relationship ((hk)(exp 2)/2m = W(1 + alphaW). The second formulation makes use of a power law ((hk)(exp 2)/2m = xW(exp y)) for the dispersion relation. Hydrodynamic models which use the first formulation rely on the binomial expansion to obtain moment equations with closed form coefficients. This limits the energy range over which the model is valid. The power law formulation readily produces closed form coefficients similar to those obtained using the parabolic band approximation. However, the fitting parameters (x,y) are only valid over a limited energy range. The physical significance of the band non-parabolicity is discussed as well as the advantages/disadvantages and approximations of the two non-parabolic models. A companion paper describes device simulations based on the three dispersion relationships; parabolic, Kane dispersion and power law dispersion.
Self-similar parabolic plasmonic beams.
Davoyan, Arthur R; Turitsyn, Sergei K; Kivshar, Yuri S
2013-02-15
We demonstrate that an interplay between diffraction and defocusing nonlinearity can support stable self-similar plasmonic waves with a parabolic profile. Simplicity of a parabolic shape combined with the corresponding parabolic spatial phase distribution creates opportunities for controllable manipulation of plasmons through a combined action of diffraction and nonlinearity.
Plane and parabolic solar panels
Sales, J H O
2009-01-01
We present a plane and parabolic collector that absorbs radiant energy and transforms it in heat. Therefore we have a panel to heat water. We study how to increment this capture of solar beams onto the panel in order to increase its efficiency in heating water.
Parabolic tapers for overmoded waveguides
Doane, J.L.
1983-11-25
A waveguide taper with a parabolic profile, in which the distance along the taper axis varies as the square of the tapered dimension, provides less mode conversion than equal length linear tapers and is easier to fabricate than other non-linear tapers.
Parabolic dunes in north-eastern Brazil
Duran, O; Bezerra, L J C; Herrmann, H J; Maia, L P
2007-01-01
In this work we present measurements of vegetation cover over parabolic dunes with different degree of activation along the north-eastern Brazilian coast. We are able to extend the local values of the vegetation cover density to the whole dune by correlating measurements with the gray-scale levels of a high resolution satellite image of the dune field. The empirical vegetation distribution is finally used to validate the results of a recent continuous model of dune motion coupling sand erosion and vegetation growth.
A Contribution for the Construction of Parabolic Mirrors
de Paula, L A N; Assis, A K T
2008-01-01
We present a new procedure for the construction of parabolic mirrors using low cost materials. We build a spinning system composed of nylon threads, fish hooks and a plastic bucket. We pour liquid plaster into the bucket and set it in constant rotational motion relative to the earth. A liquid substance assumes a parabolic profile when spinning at constant angular velocity relative to an inertial frame under the influence of an uniform vertical gravitational field. By keeping the bucket under rotation for a long time, the plaster solidifies into a parabolic format. We utilize this solidified plaster paraboloid as a model to construct a counter-mould of glass fibre and resin. Over this counter-mould it is placed stretched laminated foil and then it is poured thick plaster over it. In this way it is obtained a parabolic mirror made of laminated foil and plaster. Our only objective here is to present a new method for the construction of parabolic mirror using low cost materials. This allows further exploration of...
Jadhav, J. R.; Mantha, S. S.; Rane, S. B.
2015-12-01
`Survival of the fittest' is the reality in modern global competition. Organizations around the globe are adopting or willing to embrace just-in-time (JIT) production to reinforce the competitiveness. Even though JIT is the most powerful inventory management methodologies it is not free from barriers. Barriers derail the implementation of JIT production system. One of the most significant tasks of top management is to identify and understand the relationship between the barriers to JIT production for alleviating its bad effects. The aims of this paper are to study the barriers hampering the implementation of successful JIT production and analysing the interactions among the barriers using interpretive structural modelling technique. Twelve barriers have been identified after reviewing literature. This paper offers a roadmap for preparing an action plan to tackle the barriers in successful implementation of JIT production.
Modeling of Schottky Barrier Diode Millimeter-Wave Multipliers at Cryogenic Temperatures
Johansen, Tom K.; Rybalko, Oleksandr; Zhurbenko, Vitaliy
2015-01-01
We report on the evaluation of Schottky barrier diode GaAs multipliers at cryogenic temperatures. A GaAs Schottky barrier diode model is developed for theoretical estimation of doubler performance. The model is used to predict efficiency of doublers from room to cryogenic temperatures...
Overcoming barriers to cancer pain management: an institutional change model.
Sun, Virginia Chih-Yi; Borneman, Tami; Ferrell, Betty; Piper, Barbara; Koczywas, Marianna; Choi, Kyong
2007-10-01
The Agency for Health Care Policy and Research Pain Guidelines of 1994 recognized pain as a critical symptom that impacts quality of life (QOL). The barriers to optimum pain relief were classified into three categories: patient, professional, and system barriers. A prospective, longitudinal clinical trial is underway to test the effects of the "Passport to Comfort" innovative intervention on pain and fatigue management. This article reports on preintervention findings related to barriers to pain management. Cancer patients with a diagnosis of breast, lung, colon, or prostate cancer who reported a pain rating of >/=4 were accrued. Subjects completed questionnaires to assess subjective ratings of overall QOL, barriers to pain management, and pain knowledge at baseline and at one- and three-month evaluations. A chart audit was conducted at one month to document objective data related to pain management. The majority of subjects had moderate (4-6 on a 0-10 numeric rating scale) pain at the time of accrual. Patient barriers to pain management existed in attitudes and knowledge regarding addiction, tolerance, and not being able to control pain. Subjects who were currently receiving chemotherapy were reluctant to communicate their pain with health care professionals. Professional and system barriers were focused around screening, documentation, reassessment, and follow-up of pain. Lack of referrals to supportive care services for patients was also noted. Several well-described patient, professional, and system barriers continue to hinder efforts to provide optimal pain relief. Phase II of this initiative will attempt to eliminate these barriers using the "Passport" intervention to manage cancer pain.
Performance Evaluation and Modeling of Erosion Resistant Turbine Engine Thermal Barrier Coatings
Miller, Robert A.; Zhu, Dongming; Kuczmarski, Maria
2008-01-01
The erosion resistant turbine thermal barrier coating system is critical to the rotorcraft engine performance and durability. The objective of this work was to determine erosion resistance of advanced thermal barrier coating systems under simulated engine erosion and thermal gradient environments, thus validating a new thermal barrier coating turbine blade technology for future rotorcraft applications. A high velocity burner rig based erosion test approach was established and a new series of rare earth oxide- and TiO2/Ta2O5- alloyed, ZrO2-based low conductivity thermal barrier coatings were designed and processed. The low conductivity thermal barrier coating systems demonstrated significant improvements in the erosion resistance. A comprehensive model based on accumulated strain damage low cycle fatigue is formulated for blade erosion life prediction. The work is currently aiming at the simulated engine erosion testing of advanced thermal barrier coated turbine blades to establish and validate the coating life prediction models.
2014-07-01
Barrier Shoreline Wetland Value Assessment Model1 by S. Kyle McKay2 and J. Craig Fischenich3 OVERVIEW: Sensitivity analysis is a technique for...relevance of questions posed during an Independent External Peer Review (IEPR). BARATARIA BASIN BARRIER SHORELINE (BBBS) STUDY: On average...scale restoration projects to reduce marsh loss and maintain these wetlands as healthy functioning ecosystems. The Barataria Basin Barrier Shoreline
Meyer, J C; Needham, D J
2015-03-08
In this paper, we examine a semi-linear parabolic Cauchy problem with non-Lipschitz nonlinearity which arises as a generic form in a significant number of applications. Specifically, we obtain a well-posedness result and examine the qualitative structure of the solution in detail. The standard classical approach to establishing well-posedness is precluded owing to the lack of Lipschitz continuity for the nonlinearity. Here, existence and uniqueness of solutions is established via the recently developed generic approach to this class of problem (Meyer & Needham 2015 The Cauchy problem for non-Lipschitz semi-linear parabolic partial differential equations. London Mathematical Society Lecture Note Series, vol. 419) which examines the difference of the maximal and minimal solutions to the problem. From this uniqueness result, the approach of Meyer & Needham allows for development of a comparison result which is then used to exhibit global continuous dependence of solutions to the problem on a suitable initial dataset. The comparison and continuous dependence results obtained here are novel to this class of problem. This class of problem arises specifically in the study of a one-step autocatalytic reaction, which is schematically given by A→B at rate a(p)b(q) (where a and b are the concentrations of A and B, respectively, with 0
Viscosity solutions of fully nonlinear functional parabolic PDE
Liu Wei-an
2005-01-01
Full Text Available By the technique of coupled solutions, the notion of viscosity solutions is extended to fully nonlinear retarded parabolic equations. Such equations involve many models arising from optimal control theory, economy and finance, biology, and so forth. The comparison principle is shown. Then the existence and uniqueness are established by the fixed point theory.
On an algorithm for solving parabolic and elliptic equations
D'Ascenzo, N.; Saveliev, V. I.; Chetverushkin, B. N.
2015-08-01
The present-day rapid growth of computer power, in particular, parallel computing systems of ultrahigh performance requires a new approach to the creation of models and solution algorithms for major problems. An algorithm for solving parabolic and elliptic equations is proposed. The capabilities of the method are demonstrated by solving astrophysical problems on high-performance computer systems with massive parallelism.
An Application of Calculus: Optimum Parabolic Path Problem
Atasever, Merve; Pakdemirli, Mehmet; Yurtsever, Hasan Ali
2009-01-01
A practical and technological application of calculus problem is posed to motivate freshman students or junior high school students. A variable coefficient of friction is used in modelling air friction. The case in which the coefficient of friction is a decreasing function of altitude is considered. The optimum parabolic path for a flying object…
An Application of Calculus: Optimum Parabolic Path Problem
Atasever, Merve; Pakdemirli, Mehmet; Yurtsever, Hasan Ali
2009-01-01
A practical and technological application of calculus problem is posed to motivate freshman students or junior high school students. A variable coefficient of friction is used in modelling air friction. The case in which the coefficient of friction is a decreasing function of altitude is considered. The optimum parabolic path for a flying object…
Comparison between two models of absorption of matter waves by a thin time-dependent barrier
Barbier, Maximilien; Beau, Mathieu; Goussev, Arseni
2015-11-01
We report a quantitative, analytical, and numerical comparison between two models of the interaction of a nonrelativistic quantum particle with a thin time-dependent absorbing barrier. The first model represents the barrier by a set of time-dependent discontinuous matching conditions, which are closely related to Kottler boundary conditions used in stationary-wave optics as a mathematical basis for Kirchhoff diffraction theory. The second model mimics the absorbing barrier with an off-diagonal δ potential with a time-dependent amplitude. We show that the two models of absorption agree in their predictions in a semiclassical regime, the regime readily accessible in modern experiments with ultracold atoms.
Simulation of low Schottky barrier MOSFETs using an improved Multi-subband Monte Carlo model
Gudmundsson, Valur; Palestri, Pierpaolo; Hellström, Per-Erik; Selmi, Luca; Östling, Mikael
2013-01-01
We present a simple and efficient approach to implement Schottky barrier contacts in a Multi-subband Monte Carlo simulator by using the subband smoothening technique to mimic tunneling at the Schottky junction. In the absence of scattering, simulation results for Schottky barrier MOSFETs are in agreement with ballistic Non-Equilibrium Green's Functions calculations. We then include the most relevant scattering mechanisms, and apply the model to the study of double gate Schottky barrier MOSFETs representative of the ITRS 2015 high performance device. Results show that a Schottky barrier height of less than approximately 0.15 eV is required to outperform the doped source/drain structure.
Proton driven plasma wakefield generation in a parabolic plasma channel
Golian, Y.; Dorranian, D.
2016-11-01
An analytical model for the interaction of charged particle beams and plasma for a wakefield generation in a parabolic plasma channel is presented. In the suggested model, the plasma density profile has a minimum value on the propagation axis. A Gaussian proton beam is employed to excite the plasma wakefield in the channel. While previous works investigated on the simulation results and on the perturbation techniques in case of laser wakefield accelerations for a parabolic channel, we have carried out an analytical model and solved the accelerating field equation for proton beam in a parabolic plasma channel. The solution is expressed by Whittaker (hypergeometric) functions. Effects of plasma channel radius, proton bunch parameters and plasma parameters on the accelerating processes of proton driven plasma wakefield acceleration are studied. Results show that the higher accelerating fields could be generated in the PWFA scheme with modest reductions in the bunch size. Also, the modest increment in plasma channel radius is needed to obtain maximum accelerating gradient. In addition, the simulations of longitudinal and total radial wakefield in parabolic plasma channel are presented using LCODE. It is observed that the longitudinal wakefield generated by the bunch decreases with the distance behind the bunch while total radial wakefield increases with the distance behind the bunch.
Skin barrier disruption by acetone: observations in a hairless mouse skin model
Rissmann, R.; Oudshoorn, M.H.M.; Hennink, W.E.; Ponec, M.; Bouwstra, J.A.
2009-01-01
To disrupt the barrier function of the skin, different in vivo methods have been established, e.g., by acetone wiping or tape-stripping. In this study, the acetone-induced barrier disruption of hairless mice was investigated in order to establish a reliable model to study beneficial, long-term effec
Modeling the impact of solid noise barriers on near road air quality
Venkatram, Akula; Isakov, Vlad; Deshmukh, Parikshit; Baldauf, Richard
2016-09-01
Studies based on field measurements, wind tunnel experiments, and controlled tracer gas releases indicate that solid, roadside noise barriers can lead to reductions in downwind near-road air pollutant concentrations. A tracer gas study showed that a solid barrier reduced pollutant concentrations as much as 80% next to the barrier relative to an open area under unstable meteorological conditions, which corresponds to typical daytime conditions when residents living or children going to school near roadways are most likely to be exposed to traffic emissions. The data from this tracer gas study and a wind tunnel simulation were used to develop a model to describe dispersion of traffic emissions near a highway in the presence of a solid noise barrier. The model is used to interpret real-world data collected during a field study conducted in a complex urban environment next to a large highway in Phoenix, Arizona, USA. We show that the analysis of the data with the model yields useful information on the emission factors and the mitigation impact of the barrier on near-road air quality. The estimated emission factors for the four species, ultrafine particles, CO, NO2, and black carbon, are consistent with data cited in the literature. The results suggest that the model accounted for reductions in pollutant concentrations from a 4.5 m high noise barrier, ranging from 40% next to the barrier to 10% at 300 m from the barrier.
Program MAMLAC : a mathematical model for impacts against crash barriers.
Giavotto, V.
1972-01-01
The digital simulation system that has been developed for impact test against safety barriers has proved to be a valuable tool; it may reduce the cost of a program, or better increase largely the extent of a program without increasing the cost. In fact it may permit to reduce considerably the number
Program MAMLAC : a mathematical model for impacts against crash barriers.
Giavotto, V.
1972-01-01
The digital simulation system that has been developed for impact test against safety barriers has proved to be a valuable tool; it may reduce the cost of a program, or better increase largely the extent of a program without increasing the cost. In fact it may permit to reduce considerably the number
Yuan Wang
2015-01-01
Full Text Available Our work is devoted to a class of optimal control problems of parabolic partial differential equations. Because of the partial differential equations constraints, it is rather difficult to solve the optimization problem. The gradient of the cost function can be found by the adjoint problem approach. Based on the adjoint problem approach, the gradient of cost function is proved to be Lipschitz continuous. An improved conjugate method is applied to solve this optimization problem and this algorithm is proved to be convergent. This method is applied to set-point values in continuous cast secondary cooling zone. Based on the real data in a plant, the simulation experiments show that the method can ensure the steel billet quality. From these experiment results, it is concluded that the improved conjugate gradient algorithm is convergent and the method is effective in optimal control problem of partial differential equations.
Pépino, Marc; Rodríguez, Marco A; Magnan, Pierre
2012-07-01
Dispersal is a key determinant of the spatial distribution and abundance of populations, but human-made fragmentation can create barriers that hinder dispersal and reduce population viability. This study presents a modeling framework based on dispersal kernels (modified Laplace distributions) that describe stream fish dispersal in the presence of obstacles to passage. We used mark-recapture trials to quantify summer dispersal of brook trout (Salvelinus fontinalis) in four streams crossed by a highway. The analysis identified population heterogeneity in dispersal behavior, as revealed by the presence of a dominant sedentary component (48-72% of all individuals) characterized by short mean dispersal distance (dispersal distance (56-1086 m). We did not detect evidence of barrier effects on dispersal through highway crossings. Simulation of various plausible scenarios indicated that detectability of barrier effects was strongly dependent on features of sampling design, such as spatial configuration of the sampling area, barrier extent, and sample size. The proposed modeling framework extends conventional dispersal kernels by incorporating structural barriers. A major strength of the approach is that ecological process (dispersal model) and sampling design (observation model) are incorporated simultaneously into the analysis. This feature can facilitate the use of prior knowledge to improve sampling efficiency of mark-recapture trials in movement studies. Model-based estimation of barrier permeability and its associated uncertainty provides a rigorous approach for quantifying the effect of barriers on stream fish dispersal and assessing population dynamics of stream fish in fragmented landscapes.
陈红; 韩磊; 王广军
2013-01-01
This paper studied the dynamic characteristics of parabolic trough direct steam generation (DSG) solar collector system by using a mathematical model. Nonlinear lumped parameter mathematical models of DSG parabolic trough solar collector system were developed. For the evaporator loop of DSG solar collector system, moving boundary models under the three possible operating modes were built, and the switching schemes of the mathematical model were put forward when the operator modes of evaporator loop were changed. DSG trough solar collector system response characteristics was studied through numerical simulations in the conditions that the main disturbance operating conditions such as the solar radiation intensity and feedwater flow changed. The dynamic behaviors of the main parameters were also studied when evaporator loop operating modes changed.%该文利用数学模型研究了直接蒸汽发电(direct steam generation，DSG)槽式太阳能集热系统的动态特性。建立了DSG 槽式太阳能集热系统非线性集总参数数学模型。对于DSG集热系统中的蒸发环节，分别建立了其在3种可能运行方式下的移动边界模型，并给出了在蒸发环节运行方式发生变化时，数学模型的切换方法。通过数值仿真实验，研究了DSG槽式太阳能集热系统在太阳辐射强度变化及给水流量变化等主要扰动工况下的响应特性，分析了蒸发环节运行方式发生变化时系统主要参数的动态行为。
Two new designs of parabolic solar collectors
Karimi Sadaghiyani Omid
2014-01-01
Full Text Available In this work, two new compound parabolic trough and dish solar collectors are presented with their working principles. First, the curves of mirrors are defined and the mathematical formulation as one analytical method is used to trace the sun rays and recognize the focus point. As a result of the ray tracing, the distribution of heat flux around the inner wall can be reached. Next, the heat fluxes are calculated versus several absorption coefficients. These heat flux distributions around absorber tube are functions of angle in polar coordinate system. Considering, the achieved heat flux distribution are used as a thermal boundary condition. After that, Finite Volume Methods (FVM are applied for simulation of absorber tube. The validation of solving method is done by comparing with Dudley's results at Sandia National Research Laboratory. Also, in order to have a good comparison between LS-2 and two new designed collectors, some of their parameters are considered equal with together. These parameters are consist of: the aperture area, the measures of tube geometry, the thermal properties of absorber tube, the working fluid, the solar radiation intensity and the mass flow rate of LS-2 collector are applied for simulation of the new presented collectors. After the validation of the used numerical models, this method is applied to simulation of the new designed models. Finally, the outlet results of new designed collector are compared with LS-2 classic collector. Obviously, the obtained results from the comparison show the improving of the new designed parabolic collectors efficiency. In the best case-study, the improving of efficiency are about 10% and 20% for linear and convoluted models respectively.
Sunil Luthra
2011-07-01
Full Text Available Purpose: Green Supply Chain Management (GSCM has received growing attention in the last few years. Most of the automobile industries are setting up their own manufacturing plants in competitive Indian market. Due to public awareness, economic, environmental or legislative reasons, the requirement of GSCM has increased. In this context, this study aims to develop a structural model of the barriers to implement GSCM in Indian automobile industry.Design/methodology/approach: We have identified various barriers and contextual relationships among the identified barriers. Classification of barriers has been carried out based upon dependence and driving power with the help of MICMAC analysis. In addition to this, a structural model of barriers to implement GSCM in Indian automobile industry has also been put forward using Interpretive Structural Modeling (ISM technique. Findings: Eleven numbers of relevant barriers have been identified from literature and subsequent discussions with experts from academia and industry. Out of which, five numbers of barriers have been identified as dependent variables; three number of barriers have been identified as the driver variables and three number of barriers have been identified as the linkage variables. No barrier has been identified as autonomous variable. Four barriers have been identified as top level barriers and one bottom level barrier. Removal of these barriers has also been discussed.Research limitations/implications: A hypothetical model of these barriers has been developed based upon experts’ opinions. The conclusions so drawn may be further modified to apply in real situation problem. Practical implications: Clear understanding of these barriers will help organizations to prioritize better and manage their resources in an efficient and effective way.Originality/value: Through this paper we contribute to identify the barriers to implement GSCM in Indian automobile industry and to prioritize them
FINITE ELEMENT MODELLING AND SIMULATION OF VEHICLE IMPACT ON STEEL SAFETY BARRIERS
Raissa Likhonina
2016-12-01
Full Text Available This paper deals with a FEA simulation of the vehicle crash with steel safety barriers in ANSYS LS-DYNA® 15.0. Two types of safety barriers are used: JSNH4/H2 and JSAM-2/H2. A geometrical model of the barrier in the Modeler ANSYS® Workbench™ 15.0 was created and after that it was transformed into LS-DYNA® 15.0 to complete the crash test simulation. After computation in solver ANSYS LS-DYNA® 15.0 the results of the simulation such as impact forces, a body displacement and an integral energy were analyzed.
Immortalized endothelial cell lines for in vitro blood-brain barrier models: A systematic review.
Rahman, Nurul Adhwa; Rasil, Alifah Nur'ain Haji Mat; Meyding-Lamade, Uta; Craemer, Eva Maria; Diah, Suwarni; Tuah, Ani Afiqah; Muharram, Siti Hanna
2016-07-01
Endothelial cells play the most important role in construction of the blood-brain barrier. Many studies have opted to use commercially available, easily transfected or immortalized endothelial cell lines as in vitro blood-brain barrier models. Numerous endothelial cell lines are available, but we do not currently have strong evidence for which cell lines are optimal for establishment of such models. This review aimed to investigate the application of immortalized endothelial cell lines as in vitro blood-brain barrier models. The databases used for this review were PubMed, OVID MEDLINE, ProQuest, ScienceDirect, and SpringerLink. A narrative systematic review was conducted and identified 155 studies. As a result, 36 immortalized endothelial cell lines of human, mouse, rat, porcine and bovine origins were found for the establishment of in vitro blood-brain barrier and brain endothelium models. This review provides a summary of immortalized endothelial cell lines as a guideline for future studies and improvements in the establishment of in vitro blood-brain barrier models. It is important to establish a good and reproducible model that has the potential for multiple applications, in particular a model of such a complex compartment such as the blood-brain barrier.
Hirsch, Philipp Emanuel; Thorlacius, Magnus; Brodin, Tomas; Burkhardt-Holm, Patricia
2017-01-01
Animal personalities are an important factor that affects the dispersal of animals. In the context of aquatic species, dispersal modeling needs to consider that most freshwater ecosystems are highly fragmented by barriers reducing longitudinal connectivity. Previous research has incorporated such barriers into dispersal models under the neutral assumption that all migrating animals attempt to ascend at all times. Modeling dispersal of animals that do not perform trophic or reproductive migrations will be more realistic if it includes assumptions of which individuals attempt to overcome a barrier. We aimed to introduce personality into predictive modeling of whether a nonmigratory invasive freshwater fish (the round goby, Neogobius melanostomus) will disperse across an in-stream barrier. To that end, we experimentally assayed the personalities of 259 individuals from invasion fronts and established round goby populations. Based on the population differences in boldness, asociability, and activity, we defined a priori thresholds with bolder, more asocial, and more active individuals having a higher likelihood of ascent. We then combined the personality thresholds with swimming speed data from the literature and in situ measurements of flow velocities in the barrier. The resulting binary logistic regression model revealed probabilities of crossing a barrier which depended not only on water flow and fish swimming speed but also on animal personalities. We conclude that risk assessment through predictive dispersal modeling across fragmented landscapes can be advanced by including personality traits as parameters. The inclusion of behavior into modeling the spread of invasive species can help to improve the accuracy of risk assessments.
Blood-CNS Barrier Impairment in ALS Patients versus an Animal Model
Svitlana eGarbuzova-Davis
2014-02-01
Full Text Available Amyotrophic lateral sclerosis (ALS is a severe neurodegenerative disease with a compli-cated and poorly understood pathogenesis. Recently, alterations in the blood-Central Nervous System barrier (B-CNS-B have been recognized as a key factor possibly aggravating motor neuron damage. The majority of findings on ALS microvascular pathology have been deter-mined in mutant SOD1 rodent models, identifying barrier damage during disease develop-ment which might similarly occur in familial ALS patients carrying the SOD1 mutation. However, our knowledge of B-CNS-B competence in sporadic ALS (SALS has been limited. We recently showed structural and functional impairment in postmortem gray and white mat-ter microvessels of medulla and spinal cord tissue from SALS patients, suggesting pervasive barrier damage. Although numerous signs of barrier impairment (endothelial cell degenera-tion, capillary leakage, perivascular edema, downregulation of tight junction proteins, and microhemorrhages are indicated in both mutant SOD1 animal models of ALS and SALS pa-tients, other pathogenic barrier alterations have as yet only been identified in SALS patients. Pericyte degeneration, perivascular collagen IV expansion, and white matter capillary abnor-malities in SALS patients are significant barrier related pathologies yet to be noted in ALS SOD1 animal models. In the current review, these important differences in blood-CNS barrier damage between ALS patients and animal models, which may signify altered barrier transport mechanisms, are discussed. Understanding discrepancies in barrier condition between ALS patients and animal models may be crucial for developing effective therapies.
Genetic mouse models to study blood–brain barrier development and function
Sohet, Fabien; Daneman, Richard
2013-01-01
The blood–brain barrier (BBB) is a complex physiological structure formed by the blood vessels of the central nervous system (CNS) that tightly regulates the movement of substances between the blood and the neural tissue. Recently, the generation and analysis of different genetic mouse models has allowed for greater understanding of BBB development, how the barrier is regulated during health, and its response to disease. Here we discuss: 1) Genetic mouse models that have been used to study th...
Numerical investigation of thermal performance of heat loss of parabolic trough receiver
Modibo; Kane; TRAORE
2010-01-01
Based on the analysis of computation methods and heat transfer processes of the parabolic trough receiver running in steady state, a two-dimensional empirical model was developed to investigate the thermal performance of heat loss of parabolic trough receivers under steady state equilibrium. A numerical simulation was conducted for the parabolic trough receiver involved in a literature. Comparisons between numerical and experimental results show that the empirical model is accurate enough and can be used to investigate the thermal performance of heat loss of parabolic trough receivers. The thermal performance of heat loss of UVAC3 and the new-generation UVAC2008 was investigated respectively. The simulation results show that selective coatings and annular pressure influence the thermal performance of heat loss of parabolic trough receivers greatly, wind velocity influences the thermal performance of thermal loss of parabolic trough receivers only a little in contrast with the emittance of selective coatings and air pressure in annular space. And the thermal performance of thermal loss of the new-generation parabolic trough receiver has been improved in a large amount.
Wang Lihe; Zhou Shulin
2006-01-01
In this paper we establish the existence and uniqueness of weak solutions for the initial-boundary value problem of a nonlinear parabolic partial differential equation, which is related to the Malik-Perona model in image analysis.
Model assessment of protective barriers: Part 3. Status of FY 1990 work
Fayer, M.J.; Rockhold, M.L.; Holford, D.J.
1992-02-01
Radioactive waste exists at the US Department of Energy`s (DOE`s) Hanford Site in a variety of locations, including subsurface grout and tank farms, solid waste burial grounds, and contaminated soil sites. Some of these waste sites may need to be isolated from percolating water to minimize the potential for transport of the waste to the ground water, which eventually discharges to the Columbia River. Multilayer protective barriers have been proposed as a means of limiting the flow of water through the waste sites (DOE 1987). A multiyear research program [managed jointly by Pacific Northwest Laboratory (PNL) and Westinghouse Hanford Company for the DOE] is aimed at assessing the performance of these barriers. One aspect of this program involves the use of computer models to predict barrier performance. Three modeling studies have already been conducted and a test plan was produced. The simulation work reported here was conducted by PNL and extends the previous modeling work. The purpose of this report are to understand phenomena that have been observed in the field and to provide information that can be used to improve hydrologic modeling of the protective barrier. An improved modeling capability results in better estimates of barrier performance. Better estimates can be used to improve the design of barriers and the assessment of their long-term performance.
U.S. Geological Survey, Department of the Interior — The Barrier Island and Estuarine Wetland Physical Change Assessment was created to calibrate and test probability models of barrier island estuarine shoreline...
U.S. Geological Survey, Department of the Interior — The Barrier Island and Estuarine Wetland Physical Change Assessment was created to calibrate and test probability models of barrier island estuarine shoreline...
U.S. Geological Survey, Department of the Interior — The Barrier Island and Estuarine Wetland Physical Change Assessment was created to calibrate and test probability models of barrier island estuarine shoreline...
Long term behaviour of singularly perturbed parabolic degenerated equation
Ibrahima Faye
2016-12-01
Full Text Available In this paper we consider models built in [4] for short-term, mean-term and long-term morphodynamics of dunes and megariples. We give an existence and uniqueness result for long term dynamics of dunes. This result is based on a periodic-in-time-and-space solution existence result for degenerated parabolic equation that we set out. Finally the mean-term and long-term models are homogenized.
Long term behaviour of singularly perturbed parabolic degenerated equation
Faye, Ibrahima; Seck, Diaraf
2011-01-01
In this paper we consider models for short-term, mean-term and long-term morphodynamics of dunes and megariples. We give an existence and uniqueness result for long term dynamics of dunes. This result is based on a time-space periodic solution existence result for degenerated parabolic equation that we set out. Finally the mean-term and long-term models are homogenized.
Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices
Mieremet, Arnout; Rietveld, Marion; Absalah, Samira; van Smeden, Jeroen
2017-01-01
Full thickness human skin models (FTMs) contain an epidermal and a dermal equivalent. The latter is composed of a collagen dermal matrix which harbours fibroblasts. Current epidermal barrier properties of FTMs do not fully resemble that of native human skin (NHS), which makes these human skin models less suitable for barrier related studies. To further enhance the resemblance of NHS for epidermal morphogenesis and barrier formation, we modulated the collagen dermal matrix with the biocompatible polymer chitosan. Herein, we report that these collagen-chitosan FTMs (CC-FTMs) possess a well-organized epidermis and maintain both the early and late differentiation programs as in FTMs. Distinctively, the epidermal cell activation is reduced in CC-FTMs to levels observed in NHS. Dermal-epidermal interactions are functional in both FTM types, based on the formation of the basement membrane. Evaluation of the barrier structure by the organization of the extracellular lipid matrix of the stratum corneum revealed an elongated repeat distance of the long periodicity phase. The ceramide composition exhibited a higher resemblance of the NHS, based on the carbon chain-length distribution and subclass profile. The inside-out barrier functionality indicated by the transepidermal water loss is significantly improved in the CC-FTMs. The expression of epidermal barrier lipid processing enzymes is marginally affected, although more restricted to a single granular layer. The novel CC-FTM resembles the NHS more closely, which makes them a promising tool for epidermal barrier related studies. PMID:28333992
Chen Zhao
2016-01-01
Full Text Available It is important for huge ship to find the ceramic/metal functional gradient thermal barrier coating materials. A parallel computation model is built for optimization design of three-dimensional ceramic/metal functionally gradient thermal barrier coating material. According to the control equation and initial-boundary conditions, the heat transfer problem is considered, and numerical algorithms of optimization design is constructed by adapting difference method. The numerical results shows that gradient thermal barrier coating material can improve the function of material.
Symmetry analysis of a model for the exercise of a barrier option
O'Hara, J. G.; Sophocleous, C.; Leach, P. G. L.
2013-09-01
A barrier option takes into account the possibility of an unacceptable change in the price of the underlying stock. Such a change could carry considerable financial loss. We examine one model based upon the Black-Scholes-Merton Equation and determine the functional forms of the barrier function and rebate function which are consistent with a solution of the underlying evolution partial differential equation using the Lie Theory of Extended Groups. The solution is consistent with the possibility of no rebate and the barrier function is very similar to one adopted on an heuristic basis.
Synergies between optical and physical variables in intercepting parabolic targets.
Gómez, José; López-Moliner, Joan
2013-01-01
Interception requires precise estimation of time-to-contact (TTC) information. A long-standing view posits that all relevant information for extracting TTC is available in the angular variables, which result from the projection of distal objects onto the retina. The different timing models rooted in this tradition have consequently relied on combining visual angle and its rate of expansion in different ways with tau being the most well-known solution for TTC. The generalization of these models to timing parabolic trajectories is not straightforward. For example, these different combinations rely on isotropic expansion and usually assume first-order information only, neglecting acceleration. As a consequence no optical formulations have been put forward so far to specify TTC of parabolic targets with enough accuracy. It is only recently that context-dependent physical variables have been shown to play an important role in TTC estimation. Known physical size and gravity can adequately explain observed data of linear and free-falling trajectories, respectively. Yet, a full timing model for specifying parabolic TTC has remained elusive. We here derive two formulations that specify TTC for parabolic ball trajectories. The first specification extends previous models in which known size is combined with thresholding visual angle or its rate of expansion to the case of fly balls. To efficiently use this model, observers need to recover the 3D radial velocity component of the trajectory which conveys the isotropic expansion. The second one uses knowledge of size and gravity combined with ball visual angle and elevation angle. Taking into account the noise due to sensory measurements, we simulate the expected performance of these models in terms of accuracy and precision. While the model that combines expansion information and size knowledge is more efficient during the late trajectory, the second one is shown to be efficient along all the flight.
Synergies between optical and physical variables in intercepting parabolic targets
José eGómez
2013-05-01
Full Text Available Interception requires precise estimation of time-to-contact (TTC information. A long-standing view posits that all relevant information for extracting TTC is available in the angular variables, which result from the projection of distal objects onto the retina. The different timing models rooted in this tradition have consequently relied on combining visual angle and its rate of expansion in different ways with tau being the most well-known solution for TTC. The generalization of these models to timing parabolic trajectories is not straightforward. For example, these different combinations rely on isotropic expansion and usually assume first-order information only, neglecting acceleration. As a consequence no optical formulations have been put forward so far to specify TTC of parabolic targets with enough accuracy. It is only recently that context-dependent physical variables have been shown to play an important role in TTC estimation. Known physical size and gravity can adequately explain observed data of linear and free-falling trajectories respectively. Yet, a full timing model for specifying parabolic TTC has remained elusive. We here derive two formulations that specify TTC for parabolic ball trajectories. The first specification extends previous models in which known size is combined with thresholding visual angle or its rate of expansion to the case of fly balls. To efficiently use this model, observers need to recover the 3D radial velocity component of the trajectory which conveys the isotropic expansion. The second one uses knowledge of size and gravity combined with ball visual angle and elevation angle. Taking into account the noise due to sensory measurements, we simulate the expected performance of these models in terms of accuracy and precision. While the model that combines expansion information and size knowledge is more efficient during the late trajectory, the second one is shown to be efficient along all the flight.
Numerical Solution of Parabolic Equations
Østerby, Ole
These lecture notes are designed for a one-semester course on finite-difference methods for parabolic equations. These equations which traditionally are used for describing diffusion and heat-conduction problems in Geology, Physics, and Chemistry have recently found applications in Finance Theory....... Among the special features of this book can be mentioned the presentation of a practical approach to reliable estimates of the global error, including warning signals if the reliability is questionable. The technique is generally applicable for estimating the discretization error in numerical...... approximations which depend on a step size, such as numerical integration and solution of ordinary and partial differential equations. An integral part of the error estimation is the estimation of the order of the method and can thus satisfy the inquisitive mind: Is the order what we expect it to be from theopry...
Parabolic discounting of monetary rewards by physical effort.
Hartmann, Matthias N; Hager, Oliver M; Tobler, Philippe N; Kaiser, Stefan
2013-11-01
When humans and other animals make decisions in their natural environments prospective rewards have to be weighed against costs. It is well established that increasing costs lead to devaluation or discounting of reward. While our knowledge about discount functions for time and probability costs is quite advanced, little is known about how physical effort discounts reward. In the present study we compared three different models in a binary choice task in which human participants had to squeeze a handgrip to earn monetary rewards: a linear, a hyperbolic, and a parabolic model. On the group as well as the individual level, the concave parabolic model explained most variance of the choice data, thus contrasting with the typical hyperbolic discounting of reward value by delay. Research on effort discounting is not only important to basic science but also holds the potential to quantify aberrant motivational states in neuropsychiatric disorders.
A cluster expansion model for predicting activation barrier of atomic processes
Rehman, Tafizur; Jaipal, M. [Department of Chemical Engineering, Indian Institute of Technology Kanpur, Kanpur 208 016 (India); Chatterjee, Abhijit, E-mail: achatter@iitk.ac.in [Department of Chemical Engineering, Indian Institute of Technology Kanpur, Kanpur 208 016 (India); Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400 076 (India)
2013-06-15
We introduce a procedure based on cluster expansion models for predicting the activation barrier of atomic processes encountered while studying the dynamics of a material system using the kinetic Monte Carlo (KMC) method. Starting with an interatomic potential description, a mathematical derivation is presented to show that the local environment dependence of the activation barrier can be captured using cluster interaction models. Next, we develop a systematic procedure for training the cluster interaction model on-the-fly, which involves: (i) obtaining activation barriers for handful local environments using nudged elastic band (NEB) calculations, (ii) identifying the local environment by analyzing the NEB results, and (iii) estimating the cluster interaction model parameters from the activation barrier data. Once a cluster expansion model has been trained, it is used to predict activation barriers without requiring any additional NEB calculations. Numerical studies are performed to validate the cluster expansion model by studying hop processes in Ag/Ag(100). We show that the use of cluster expansion model with KMC enables efficient generation of an accurate process rate catalog.
Mira Schroten
Full Text Available Epithelial cells of the plexus choroideus form the structural basis of the blood-cerebrospinal fluid barrier (BCSFB. In vitro models of the BCSFB presenting characteristics of a functional barrier are of significant scientific interest as tools for examination of BCSFB function. Due to a lack of suitable cell lines as in vitro models, primary porcine plexus epithelial cells were subjected to a series of selective cultivation steps until a stable continuous subcultivatable epithelial cell line (PCP-R was established. PCP-R cells grow in a regular polygonal pattern with a doubling time of 28-36 h. At a cell number of 1.5×10(5 in a 24-well plate confluence is reached in 56-72 h. Cells are cytokeratin positive and chromosomal analysis revealed 56 chromosomes at peak (84th subculture. Employing reverse transcription PCR mRNA expression of several transporters and components of cell junctions could be detected. The latter includes tight junction components like Claudin-1 and -3, ZO-1, and Occludin, and the adherens junction protein E-cadherin. Cellular localization studies of ZO-1, Occludin and Claudin-1 by immunofluorescence and morphological analysis by electron microscopy demonstrated formation of a dense tight junction structure. Importantly, when grown on cell culture inserts PCP-R developed typical characteristics of a functional BCSFB including high transepithelial electrical resistance above 600 Ω×cm(2 as well as low permeability for macromolecules. In summary, our data suggest the PCP-R cell line as a suitable in vitro model of the porcine BCSFB.
Zheng, L.; Xu, H.; Rutqvist, J.; Birkholzer, J. T.
2016-12-01
The most common buffer material for engineered barrier system (EBS) is compacted bentonite, which features low permeability and high retardation of radionuclide transport. The safety functions of EBS bentonite include limiting transport in the near field; damping the shear movement of the host rock; preventing the sinking of canisters, limiting pressure on the canister and rock, and reducing microbial activity. To assess whether EBS bentonite can maintain these favorable features when undergoing heating from the waste package and hydration from the host rock, we need a thorough understanding of the thermal, hydrological, mechanical, and chemical evolution of bentonite under disposal conditions. The FEBEX (Full-scale Engineered Barrier EXperiment) in situ test was dismantled after 18 years' heating and hydration. The comprehensive THMC data obtained in the test provide a unique opportunity to validate coupled THMC models and deepen our understanding of the THMC evolution in bentonite. In this presentation, coupled THMC models were developed for the in situ test. Water content data obtained after dismantling and relative humidity data measured real time showed that the hydration of bentonite is slower than predicted by the typical Darcy flow model. Including Non-Darcian flow into the model however leads a significant underestimation of the relative humidity data. The reason could be that the calibration of relative permeability (and retention curve) already encompasses the nonlinear relationship between gradient and flux for bentonite, which would obviate the consideration of Non-Darcian flow in the model. THMC models that take into account the porosity and permeability changes due to mechanical processes match reasonably well all the THM data. However, they did not provide a desirable fit of the measured Cl concentration profile, further calibration of porosity/permeability changes over the course of hydration and swelling and considering thermal osmosis eventually
An improved model for noise barriers in a moving fluid
Ahmad, Bashir
2006-09-01
We study a problem of diffraction of a cylindrical acoustic wave from an absorbing half plane in a moving fluid introducing Myers' condition [M.K. Myers, On the acoustic boundary condition in the presence of flow, J. Sound Vibration 71 (1980) 429] and present an improved form of the analytic solution for the diffracted field. The importance of the work lies in the fact that Myers' condition (a generalization of Ingard's impedance condition) is now the accepted form of the boundary condition for impedance barriers with flow and hence yields a correct form of the field. The method of solution consists of Fourier transform, Wiener-Hopf technique and the modified method of stationary phase.
Parabolic replicator dynamics and the principle of minimum Tsallis information gain.
Karev, Georgy P; Koonin, Eugene V
2013-08-11
Non-linear, parabolic (sub-exponential) and hyperbolic (super-exponential) models of prebiological evolution of molecular replicators have been proposed and extensively studied. The parabolic models appear to be the most realistic approximations of real-life replicator systems due primarily to product inhibition. Unlike the more traditional exponential models, the distribution of individual frequencies in an evolving parabolic population is not described by the Maximum Entropy (MaxEnt) Principle in its traditional form, whereby the distribution with the maximum Shannon entropy is chosen among all the distributions that are possible under the given constraints. We sought to identify a more general form of the MaxEnt principle that would be applicable to parabolic growth. We consider a model of a population that reproduces according to the parabolic growth law and show that the frequencies of individuals in the population minimize the Tsallis relative entropy (non-additive information gain) at each time moment. Next, we consider a model of a parabolically growing population that maintains a constant total size and provide an "implicit" solution for this system. We show that in this case, the frequencies of the individuals in the population also minimize the Tsallis information gain at each moment of the 'internal time" of the population. The results of this analysis show that the general MaxEnt principle is the underlying law for the evolution of a broad class of replicator systems including not only exponential but also parabolic and hyperbolic systems. The choice of the appropriate entropy (information) function depends on the growth dynamics of a particular class of systems. The Tsallis entropy is non-additive for independent subsystems, i.e. the information on the subsystems is insufficient to describe the system as a whole. In the context of prebiotic evolution, this "non-reductionist" nature of parabolic replicator systems might reflect the importance of group
International Workshop on Elliptic and Parabolic Equations
Schrohe, Elmar; Seiler, Jörg; Walker, Christoph
2015-01-01
This volume covers the latest research on elliptic and parabolic equations and originates from the international Workshop on Elliptic and Parabolic Equations, held September 10-12, 2013 at the Leibniz Universität Hannover. It represents a collection of refereed research papers and survey articles written by eminent scientist on advances in different fields of elliptic and parabolic partial differential equations, including singular Riemannian manifolds, spectral analysis on manifolds, nonlinear dispersive equations, Brownian motion and kernel estimates, Euler equations, porous medium type equations, pseudodifferential calculus, free boundary problems, and bifurcation analysis.
Analysis of the Quality of Parabolic Flight
Lambot, Thomas; Ord, Stephan F.
2016-01-01
Parabolic flights allow researchers to conduct several 20 second micro-gravity experiments in the course of a single day. However, the measurement can have large variations over the course of a single parabola, requiring the knowledge of the actual flight environment as a function of time. The NASA Flight Opportunities program (FO) reviewed the acceleration data of over 400 parabolic flights and investigated the quality of micro-gravity for scientific purposes. It was discovered that a parabolic flight can be segmented into multiple parts of different quality and duration, a fact to be aware of when planning an experiment.
Self-consistent treatment of v-groove quantum wire band structure in no parabolic approximation
Crnjanski Jasna V.
2004-01-01
Full Text Available The self-consistent no parabolic calculation of a V-groove-quantum-wire (VQWR band structure is presented. A comparison with the parabolic flat-band model of VQWR shows that both, the self-consistency and the nonparabolicity shift sub band edges, in some cases even in the opposite directions. These shifts indicate that for an accurate description of inter sub band absorption, both effects have to be taken into the account.
Stability of the Shallow Axisymmetric Parabolic-Conic Bimetallic Shell by Nonlinear Theory
M. Jakomin; Kosel, F.
2011-01-01
In this contribution, we discuss the stress, deformation, and snap-through conditions of thin, axi-symmetric, shallow bimetallic shells of so-called parabolic-conic and plate-parabolic type shells loaded by thermal loading. According to the theory of the third order that takes into account the balance of forces on a deformed body, we present a model with a mathematical description of the system geometry, displacements, stress, and thermoelastic deformations. The equations are based on the lar...
Mossoulina, O. A.; Kirilenko, M. S.; Khonina, S. N.
2016-08-01
We use radial Fractional Fourier transform to model vortex laser beams propagation in optical waveguides with parabolic dependence of the refractive index. To overcome calculation difficulties at distances proportional to a quarter of the period we use varied calculation step. Numerical results for vortex modes superposition propagation in a parabolic optical fiber show that the transverse beam structure can be changed significantly during the propagation. To provide stable transverse distribution input scale modes should be in accordance with fiber parameters.
McCabe, G.J.
1989-01-01
Errors of the Thornthwaite model can be analyzed using adjusted pan evaporation as an index of potential evapotranspiration. An examination of ratios of adjusted pan evaporation to Thornthwaite potential evapotranspiration indicates that the ratios are highest in the winter and lowest during summer months. This trend suggests a parabolic pattern. In this study a parabolic function is used to adjust Thornthwaite estimates of potential evapotranspiration. Forty locations east of the Rocky Mountains are analyzed. -from Author
MODELING OF OCCUPANT DYNAMIC RESPONSE TO CAR-BARRIERS CRASH ON HIGHWAY
Huang Hongwu; Yang Jikuang; Liu Zhengheng; Zhong Zhihua
2004-01-01
The dynamic response involved in car-roadside barrier impacts is studied.The risk of occupant injures in such accidents is investigated.An approach based on accident analysis and mathematical modeling is developed and described in three steps.Firstly a study of car-roadside barrier impact accidents is carried out with available data to define a system including car,road,roadside barrier,and occupant.Secondly a mathematical model to simulate car-to-barrier impact is developed by using multi-body program MADYMO.Finally,dynamic responses of the occupant during impact are simulated using a car compartment model with a HYBRID III occupant model and an input load pulse calculated in the second step.The dynamic responses of the car are analyzed by changing impact conditions such as impact angle and impact velocity.The injury risks of the occupants are discussed in terms of the occupant kinematics and calculated parameters:accelerations of the head,chest,and pelvis,as well as HIC value.Verification of model with experimental data is performed.Possible countermeasures for highway vehicle traffic safety and improvement of roadside barrier design are presented.Research prospects in this field are also proposed.
Varakin, A I; Mazur, V V; Arkhipova, N V; Serianov, Iu V
2009-01-01
Mathematical models of the transfer of charged macromolecules have been constructed on the basis of the classical equations of electromigration diffusion of Helmholtz-Smolukhovskii, Goldman, and Goldman-Hodgkin-Katz. It was shown that ion transfer in placental (mimicking lipid-protein barriers) and muscle barriers occurs by different mechanisms. In placental barriers, the electromigration diffusion occurs along lipid-protein channels formed due to the conformational deformation of phospholipid and protein molecules with the coefficients of diffusion D = (2.6-3.6) x 10(-8) cm2/s. The transfer in muscle barriers is due to the migration across charged interfibrillar channels with the negative diffusion activation energy, which is explained by changes in the structure of muscle fibers and expenditures of thermal energy for the extrusion of Cl- from channel walls with the diffusion coefficient D = (6.0-10.0) x 10(-6) cm2/s.
Quantum compact model for thin-body double-gate Schottky barrier MOSFETs
Luan Su-Zhen; Liu Hong-Xia
2008-01-01
Nanoscale Schottky barrier metal oxide semiconductor field-effect transistors (MOSFETs) are explored by using quantum mechanism effects for thin-body devices. The results suggest that for small nonnegative Schottky barrier heights, even for zero barrier height, the tunnelling current also plays a role in the total on-state current. Owing to the thin body of device, quantum confinement raises the electron energy levels in the silicon, and the tradeoff takes place between the quantum confinement energy and Schottky barrier lowering (SBL). It is concluded that the inclusion of the quantum mechanism effect in this model, which considers an infinite rectangular well with a first-order perturbation in the channel, can lead to the good agreement with numerical result for thin silicon film. The error increases with silicon thickness increasing.
Improved Quantum Molecular Dynamics Model and its Application to Fusion Reaction Near Barrier
2001-01-01
An improved quantum molecular dynamics model is proposed. By using this model, the properties of ground state of nuclei from 6Li to 208Pb can be described very well with one set of parameters. The fusion reactions for 40Ca+90Zr, 40Ca+96Zr and 48Ca+90Zr at the energy near the barrier are studied by this model. The experimental data of the fusion cross sections for 40Ca+90,96Zr at the energy near the barrier can be reproduced remarkably well without introducing any new parameters. The mechanism
The dividend function in the jump-diffusion dual model with barrier dividend strategy
LI Bo; WU Rong
2008-01-01
A dual model of the perturbed classical compound Poisson risk model is considered under a constant dividend barrier.A new method is used in deriving the boundary condition of the equation for the expectation function by studying the local time of a related process.We obtain the expression for the expected discount dividend function in terms of those in the corresponding perturbed compound Poisson risk model without barriers.A special case in which the gain size is phase-type distributed is illustrated.We also consider the existence of the optimal dividend level.
Parabolic dish reflectors for solar applications approximated by simple surfaces
Broman, Lars; Broman, Arne
1996-01-01
Two different concentrating mirrors have been constructed that resemble parabolic dish reflectors. Both mirrors are made of slightly curved strips of flat, bendable material. The strips of the most simplified mirror have only large-radius circles and straight lines as boundaries. The necessary equations for making the mirrors have been derived. Also a simple way to make a stiff, lightweight frame and support for the mirror strips has been developed. Models of the mirrors have been built and s...
Thermal distortion analysis of a deployable parabolic reflector
Bruck, L. R.; Honeycutt, G. H.
1973-01-01
A thermal distortion analysis of the ATS-6 Satellite parabolic reflector was performed using NASTRAN level 15.1. The same NASTRAN finite element method was used to conduct a one g static load analysis and a dynamic analysis of the reflector. In addition, a parametric study was made to determine which parameters had the greatest effect on the thermal distortions. The method used to model the construction of the reflector is described and the results of the analyses are presented.
Homogenization of a nonlinear degenerate parabolic equation
无
2005-01-01
The homogenization of one kind of nonlinear parabolic equation is studied. The weak convergence and corrector results are obtained by combining carefully the compactness method and two-scale convergence method in the homogenization theory.
Reflective Properties of a Parabolic Mirror.
Ramsey, Gordon P.
1991-01-01
An incident light ray parallel to the optical axis of a parabolic mirror will be reflected at the focal point and vice versa. Presents a mathematical proof that uses calculus, algebra, and geometry to prove this reflective property. (MDH)
POSITIVE EQUILIBRIUM SOLUTIONS OF SEMILINEAR PARABOLIC EQUATIONS
无
2006-01-01
The author studies semilinear parabolic equations with initial and periodic boundary value conditions. In the presence of non-well-ordered sub- and super-solutions:"subsolution (≤) supersolution", the existence and stability/instability of equilibrium solutions are obtained.
José Colina-Márquez
2015-07-01
Full Text Available Endocrine disruptors in water are contaminants of emerging concern due to the potential risks they pose to the environment and to the aquatic ecosystems. In this study, a solar photocatalytic treatment process in a pilot-scale compound parabolic collector (CPC was used to remove commercial estradiol formulations (17-β estradiol and nomegestrol acetate from water. Photolysis alone degraded up to 50% of estradiol and removed 11% of the total organic carbon (TOC. In contrast, solar photocatalysis degraded up to 57% of estrogens and the TOC removal was 31%, with 0.6 g/L of catalyst load (TiO2 Aeroxide P-25 and 213.6 ppm of TOC as initial concentration of the commercial estradiols formulation. The adsorption of estrogens over the catalyst was insignificant and was modeled by the Langmuir isotherm. The TOC removal via photocatalysis in the photoreactor was modeled considering the reactor fluid-dynamics, the radiation field, the estrogens mass balance, and a modified Langmuir–Hinshelwood rate law, that was expressed in terms of the rate of photon adsorption. The optimum removal of the estrogens and TOC was achieved at a catalyst concentration of 0.4 g/L in 29 mm diameter tubular CPC reactors which approached the optimum catalyst concentration and optical thickness determined from the modeling of the absorption of solar radiation in the CPC, by the six-flux absorption-scattering model (SFM.
Colina-Márquez, José; Machuca-Martínez, Fiderman; Li Puma, Gianluca
2015-07-22
Endocrine disruptors in water are contaminants of emerging concern due to the potential risks they pose to the environment and to the aquatic ecosystems. In this study, a solar photocatalytic treatment process in a pilot-scale compound parabolic collector (CPC) was used to remove commercial estradiol formulations (17-β estradiol and nomegestrol acetate) from water. Photolysis alone degraded up to 50% of estradiol and removed 11% of the total organic carbon (TOC). In contrast, solar photocatalysis degraded up to 57% of estrogens and the TOC removal was 31%, with 0.6 g/L of catalyst load (TiO2 Aeroxide P-25) and 213.6 ppm of TOC as initial concentration of the commercial estradiols formulation. The adsorption of estrogens over the catalyst was insignificant and was modeled by the Langmuir isotherm. The TOC removal via photocatalysis in the photoreactor was modeled considering the reactor fluid-dynamics, the radiation field, the estrogens mass balance, and a modified Langmuir-Hinshelwood rate law, that was expressed in terms of the rate of photon adsorption. The optimum removal of the estrogens and TOC was achieved at a catalyst concentration of 0.4 g/L in 29 mm diameter tubular CPC reactors which approached the optimum catalyst concentration and optical thickness determined from the modeling of the absorption of solar radiation in the CPC, by the six-flux absorption-scattering model (SFM).
陈玉英
2016-01-01
槽式太阳能集热器一维和二维传热数学模型是一组非线性代数方程，为改进求解的稳定性和计算精度，将槽式太阳能集热器一维和二维传热模型的求解看作有约束优化问题，建立了集热器传热过程求解的有约束优化数学模型，应用 MATLAB 软件优化函数fmincon 进行求解。分析了传热流体入口温度及太阳能辐射热流密度变化对集热器性能的影响。采用fmincon 函数求解集热器传热过程，计算速度快，计算过程稳定。分析表明，传热流体温度变化对集热器效率的影响大于太阳能辐射热流密度对集热器效率的影响。%One-dimensional and two-dimensional heat transfer mathematic model of the parabolic trough solar collector are a set of nonlinear algebra equations.In order to promote the stability and accuracy of the solution ,the calculation of the heat transfer model of the parabolic trough solar energy collector is treated as constrained optimum problem, the energy conservation equations and heat transfer equations are converted into optimization model,the optimization model is solved by using fmincon function in MATLAB optimization tool box.The influences of heat transfer fluid inlet temperature and solar radiation flux to heat collector coefficient are analyzed.The solution of heat collector heat transfer process is faster and more stable by using fmincon function.Results show that the variation of heat transfer fluid inlet temperature plays more important role on heat collector coefficient than that of the variation of solar radiation flux.
Use of element model to evaluate transmissibility reduction due to barriers
Svanes, T.; South, D.; Dronen, O.M. [Statoil, Bergen (Norway)
1997-08-01
Water breakthrough has been observed a year earlier than expected in the productive Oseberg Formation in the Veslefrikk Field. Production data revealed extensive water override, whereas the opposite situation was expected based on a homogeneous and coarse flow simulation model. A new model was developed to include geological heterogeneities using a simple upscaling method. The Oseberg Fm. consists of an upper homogeneous unit (zone 2) and a lower unit containing thin barriers of shale and calcite cemented sandstone (zone 1). The barrier content varies laterally. When barriers are distributed in a complex 3D pattern, they reduce the upscaled horizontal transmissibility more than what is obtained by multiplying the sand permeability by the net-to-gross ratio (N/G). However, the transmissibility reduction strongly depends on the spatial distribution of barriers and their geometry. Therefore, a fine scale element model was used to derive the average transmissibility reduction as a function of N/G for alternative geological descriptions of the barriers. A geo-statistical method called General Marked Point Process was used to generate the fine scale descriptions. This work has resulted in a simple upscaling routine for horizontal transmissibility, which represents an effective bridge between geological evaluation of uncertainties and fluid flow simulation. The method combines geo-statistical and deterministic modelling in an elegant manner, recognising that most often these methods complement one another.
Turbulence in edge and core transport barriers: new experimental results and modeling
Tokuzawa, T.
2017-02-01
In this paper, recent progressive studies on experimental analysis and theoretical models for turbulence phenomena around the transport barriers in high-performance magnetic confined fusion plasma are reviewed. The linkage of radial electric fields and turbulence, the importance of radial electric field curvature, and observations of spatiotemporal turbulence structures are described with related theoretical models.
Partial differential equations of parabolic type
Friedman, Avner
2008-01-01
This accessible and self-contained treatment provides even readers previously unacquainted with parabolic and elliptic equations with sufficient background to understand research literature. Author Avner Friedman - Director of the Mathematical Biosciences Institute at The Ohio State University - offers a systematic and thorough approach that begins with the main facts of the general theory of second order linear parabolic equations. Subsequent chapters explore asymptotic behavior of solutions, semi-linear equations and free boundary problems, and the extension of results concerning fundamenta
Naganathan, Athi N; Perez-Jimenez, Raul; Muñoz, Victor; Sanchez-Ruiz, Jose M
2011-10-14
The realization that folding free energy barriers can be small enough to result in significant population of the species at the barrier top has sprouted in several methods to estimate folding barriers from equilibrium experiments. Some of these approaches are based on fitting the experimental thermogram measured by differential scanning calorimetry (DSC) to a one-dimensional representation of the folding free-energy surface (FES). Different physical models have been used to represent the FES: (1) a Landau quartic polynomial as a function of the total enthalpy, which acts as an order parameter; (2) the projection onto a structural order parameter (i.e. number of native residues or native contacts) of the free energy of all the conformations generated by Ising-like statistical mechanical models; and (3) mean-field models that define conformational entropy and stabilization energy as functions of a continuous local order parameter. The fundamental question that emerges is how can we obtain robust, model-independent estimates of the thermodynamic folding barrier from the analysis of DSC experiments. Here we address this issue by comparing the performance of various FES models in interpreting the thermogram of a protein with a marginal folding barrier. We chose the small α-helical protein PDD, which folds-unfolds in microseconds crossing a free energy barrier previously estimated as ~1 RT. The fits of the PDD thermogram to the various models and assumptions produce FES with a consistently small free energy barrier separating the folded and unfolded ensembles. However, the fits vary in quality as well as in the estimated barrier. Applying Bayesian probabilistic analysis we rank the fit performance using a statistically rigorous criterion that leads to a global estimate of the folding barrier and its precision, which for PDD is 1.3 ± 0.4 kJ mol(-1). This result confirms that PDD folds over a minor barrier consistent with the downhill folding regime. We have further
Irrigation market for solar thermal parabolic dish systems
Habib-Agahi, H.; Jones, S. C.
1981-01-01
The potential size of the onfarm-pumped irrigation market for solar thermal parabolic dish systems in seven high-insolation states is estimated. The study is restricted to the displacement of three specific fuels: gasoline, diesel and natural gas. The model was developed to estimate the optimal number of parabolic dish modules per farm based on the minimum cost mix of conventional and solar thermal energy required to meet irrigation needs. The study concludes that the potential market size for onfarm-pumped irrigation applications ranges from 101,000 modules when a 14 percent real discount rate is assumed to 220,000 modules when the real discount rate drops to 8 percent. Arizona, Kansas, Nebraska, New Mexico and Texas account for 98 percent of the total demand for this application, with the natural gas replacement market accounting for the largest segment (71 percent) of the total market.
Propagation equation for tight-focusing by a parabolic mirror.
Couairon, A; Kosareva, O G; Panov, N A; Shipilo, D E; Andreeva, V A; Jukna, V; Nesa, F
2015-11-30
Part of the chain in petawatt laser systems may involve extreme focusing conditions for which nonparaxial and vectorial effects have high impact on the propagation of radiation. We investigate the possibility of using propagation equations to simulate numerically the focal spot under these conditions. We derive a unidirectional propagation equation for the Hertz vector, describing linear and nonlinear propagation under situations where nonparaxial diffraction and vectorial effects become significant. By comparing our simulations to the results of vector diffraction integrals in the case of linear tight-focusing by a parabolic mirror, we establish a practical criterion for the critical f -number below which initializing a propagation equation with a parabolic input phase becomes inaccurate. We propose a method to find suitable input conditions for propagation equations beyond this limit. Extreme focusing conditions are shown to be modeled accurately by means of numerical simulations of the unidirectional Hertz-vector propagation equation initialized with suitable input conditions.
Modeling barrier island response to sea-level rise in the outer Banks, North Carolina
Moore, Laura J.; List, Jeffrey H.; Williams, S. Jeffress; Stolper, David
2007-01-01
An 8500-year Holocene simulation developed in GEOMBEST provides a possible scenario to explain the evolution of barrier coast between Rodanthe and Cape Hatteras, NC. Sensitivity analyses suggest that in the Outer Banks, the rate of sea-level rise is the most important factor in determining how barrier islands evolve. The Holocene simulation provides a basis for future simulations, which suggest that if sea level rises up to 0.88 m by AD 2100, as predicted by the highest estimates of the Intergovernmental Panel on Climate Change, the barrier in the study area may migrate on the order of 2.5 times more rapidly than at present. If sea level rises beyond IPCC predictions to reach 1.4–1.9 m above modern sea level by AD 2100, model results suggest that barrier islands in the Outer Banks may become vulnerable to threshold collapse, disintegrating during storm events, by the end of the next century. Consistent with sensitivity analyses, additional simulations indicate that anthropogenic activities, such as increasing the rate of sediment supply through beach nourishment, will only slightly affect barrier island migration rates and barrier island vulnerability to collapse.
Steadily translating parabolic dissolution fingers
Kondratiuk, Paweł
2015-01-01
Dissolution fingers (or wormholes) are formed during the dissolution of a porous rock as a result of nonlinear feedbacks between the flow, transport and chemical reactions at pore surfaces. We analyze the shapes and growth velocities of such fingers within the thin-front approximation, in which the reaction is assumed to take place instantaneously with the reactants fully consumed at the dissolution front. We concentrate on the case when the main flow is driven by the constant pressure gradient far from the finger, and the permeability contrast between the inside and the outside of the finger is finite. Using Ivantsov ansatz and conformal transformations we find the family of steadily translating fingers characterized by a parabolic shape. We derive the reactant concentration field and the pressure field inside and outside of the fingers and show that the flow within them is uniform. The advancement velocity of the finger is shown to be inversely proportional to its radius of curvature in the small P\\'{e}clet...
Noise barriers and the harmonoise sound propagation model
Salomons, E.M.; Maercke, D. van; Randrianoelina, A.
2009-01-01
The Harmonoise sound propagation model ('the Harmonoise engineering model') was developed in the European project Harmonoise (2001-2004) for road and rail traffic noise. In 2008, CSTB Grenoble and TNO Delft have prepared a detailed description of the various steps involved in a calculation with the
Elrawemi, Mohamed, E-mail: Mohamed.elrawemi@hud.ac.uk [EPSRC Centre for Innovative Manufacturing in Advanced Metrology, School of Computing and Engineering, University of Huddersfield, Huddersfield (United Kingdom); Blunt, Liam; Fleming, Leigh [EPSRC Centre for Innovative Manufacturing in Advanced Metrology, School of Computing and Engineering, University of Huddersfield, Huddersfield (United Kingdom); Bird, David, E-mail: David.Bird@uk-cpi.com [Centre for Process Innovation Limited, Sedgefield, County Durham (United Kingdom); Robbins, David [Centre for Process Innovation Limited, Sedgefield, County Durham (United Kingdom); Sweeney, Francis [EPSRC Centre for Innovative Manufacturing in Advanced Metrology, School of Computing and Engineering, University of Huddersfield, Huddersfield (United Kingdom)
2014-11-03
Transparent barrier films such as Al{sub 2}O{sub 3} used for prevention of oxygen and/or water vapour permeation are the subject of increasing research interest when used for the encapsulation of flexible photovoltaic modules. However, the existence of micro-scale defects in the barrier surface topography has been shown to have the potential to facilitate water vapour ingress, thereby reducing cell efficiency and causing internal electrical shorts. Previous work has shown that small defects (≤ 3 μm lateral dimension) were less significant in determining water vapour ingress. In contrast, larger defects (≥ 3 μm lateral dimension) seem to be more detrimental to the barrier functionality. Experimental results based on surface topography segmentation analysis and a model presented in this paper will be used to test the hypothesis that the major contributing defects to water vapour transmission rate are small numbers of large defects. The model highlighted in this study has the potential to be used for gaining a better understanding of photovoltaic module efficiency and performance. - Highlights: • A model of water vapour permeation through barrier defects is presented. • The effect of the defects on the water vapour permeability is investigated. • Defect density correlates with water vapour permeability. • Large defects may dominate the permeation properties of the barrier film.
Particle-in-cell modeling of gas-confined barrier discharge
Levko, Dmitry; Raja, Laxminarayan L.
2016-04-01
Gas-confined barrier discharge is studied using the one-dimensional Particle-in-Cell Monte Carlo Collisions model for the conditions reported by Guerra-Garcia and Martinez-Sanchez [Appl. Phys. Lett. 106, 041601 (2015)]. Depending on the applied voltage, two modes of discharge are observed. In the first mode, the discharge develops in the entire interelectrode gap. In the second mode, the discharge is ignited and develops only in the gas layer having smaller breakdown voltage. The one-dimensional model shows that for the conditions considered, there is no streamer stage of breakdown as is typical for a traditional dielectric barrier discharge.
On Optimality of the Barrier Strategy for the Classical Risk Model with Interest
Ying Fang; Rong Wu
2011-01-01
In this paper, we consider the optimal dividend problem for a classical risk model with a constant force of interest. For such a risk model, a sufficient condition under which a barrier strategy is the optimal strategy is presented for general claim distributions. When claim sizes are exponentially distributed, it is shown that the optimal dividend policy is a barrier strategy and the maximal dividend-value function is a concave function. Finally, some known results relating to the distribution of aggregate dividends before ruin are extended.
Particle-in-cell modeling of gas-confined barrier discharge
Levko, Dmitry; Raja, Laxminarayan L. [Department of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, Texas 78712 (United States)
2016-04-15
Gas-confined barrier discharge is studied using the one-dimensional Particle-in-Cell Monte Carlo Collisions model for the conditions reported by Guerra-Garcia and Martinez-Sanchez [Appl. Phys. Lett. 106, 041601 (2015)]. Depending on the applied voltage, two modes of discharge are observed. In the first mode, the discharge develops in the entire interelectrode gap. In the second mode, the discharge is ignited and develops only in the gas layer having smaller breakdown voltage. The one-dimensional model shows that for the conditions considered, there is no streamer stage of breakdown as is typical for a traditional dielectric barrier discharge.
Modeling Safety Barriers and Defense in Depth with Mulitlevel Flow Modeling
Lind, Morten
2012-01-01
The barrier concept plays a central role in designand operation of safety critical processes. In plant design barriers are provided as means of prevention to avoid critical process conditions which may be harmful to the environment. In plant operations barriers may beestablished and maintained...... through control actions in order to limit the consequences of critical plant events. The barrier concept has had a significant practical value for industry by guiding the design thinking of safety engineers. The provision of material barriers preventing the release of radioactive materials from...... the reactor core to the environment is accordingly a basic principle of nuclear safety design. The application of barriers is furthermore an integral part of the defence in depth principle applied by nuclear industry. Here several barriers are combined with reliability techniques such as redundancy...
Parabolic Trough Solar Collector Initial Trials
Ghalya Pikra
2012-03-01
Full Text Available This paper discusses initial trials of parabolic trough solar collector (PTSC in Bandung. PTSC model consists of concentrator, absorber and tracking system. Concentrator designs are made with 2m aperture width, 6m length and 0.75m focal distance. The design is equipped with an automatic tracking system which is driven using 12V and 24Watt DC motor with 0.0125rpm rotational speed. Absorber/receiver is designed with evacuated tube type, with 1 inch core diameter and tube made of AISI304 and coated with black oxide, the outer tube is borosilicate glass with a 70 mm diameter and 1.5 m length. Working fluid stored in single type of thermal storage tank, a single phase with 37.7 liter volume. PTSC model testing carried out for 2 hours and 10 minutes produces heat output and input of 11.5 kW and 0.64 kW respectively.
Modelling the field behaviour of a granular expansive barrier
Alonso, Eduardo; Hoffmann, Christian
The large scale “Engineered Barrier” (EB) experiment, performed at the Mont Terri Underground Laboratory is described. A coupled hydromechanical model is then used to simulate the test performance. Constitutive parameters for the bentonite granular backfill are based on experimental work described in a companion paper. An elastoplastic model describes the granular fill, while the host rock is simulated by a damage model. Predictions of EDZ development around the tunnel are compared with some indirect measurements. Calculated evolutions of relative humidity and stresses within the buffer are compared with sensor records. Good agreement was found for the bentonite blocks supporting the canister. The granular expansive fill exhibit a more irregular behavior. Calculated displacements of the canister agree in absolute terms with actual measurements.
The declared barriers of the large developing countries waste management projects: The STAR model.
Bufoni, André Luiz; Oliveira, Luciano Basto; Rosa, Luiz Pinguelli
2016-06-01
The aim of this study is to investigate and describe the barriers system that precludes the feasibility, or limits the performance of the waste management projects through the analysis of which are the declared barriers at the 432 large waste management projects registered as CDM during the period 2004-2014. The final product is a waste management barriers conceptual model proposal (STAR), supported by literature and corroborated by projects design documents. This paper uses the computer assisted qualitative content analysis (CAQCA) methodology with the qualitative data analysis (QDA) software NVivo®, by 890 fragments, to investigate the motives to support our conclusions. Results suggest the main barriers classification in five types: sociopolitical, technological, regulatory, financial, and human resources constraints. Results also suggest that beyond the waste management industry, projects have disadvantages added related to the same barriers inherent to others renewable energies initiatives. The STAR model sheds some light over the interactivity and dynamics related to the main constraints of the industry, describing the mutual influences and relationships among each one. Future researches are needed to better and comprehensively understand these relationships and ease the development of tools to alleviate or eliminate them.
Electron thermal transport barriers in RTP: experiment and modelling
Schilham, A.M.R.; Hogeweij, G. M. D.; Cardozo, N. J. L.
2001-01-01
Experiments in which very localized electron cyclotron heating (ECH) is scanned through the RTP plasma show sharp transitions, in which the electron temperature profile abruptly changes shape. The phenomenology-the profiles shapes, the sharp transitions-can be reproduced with a transport model which
Simplified 2DEG carrier concentration model for composite barrier AlGaN/GaN HEMT
Das, Palash, E-mail: d.palash@gmail.com; Biswas, Dhrubes, E-mail: d.palash@gmail.com [Indian Institute of Technology Kharagpur, Kharagpur - 721302, West Bengal (India)
2014-04-24
The self consistent solution of Schrodinger and Poisson equations is used along with the total charge depletion model and applied with a novel approach of composite AlGaN barrier based HEMT heterostructure. The solution leaded to a completely new analytical model for Fermi energy level vs. 2DEG carrier concentration. This was eventually used to demonstrate a new analytical model for the temperature dependent 2DEG carrier concentration in AlGaN/GaN HEMT.
Asymptotic analysis of a coupled nonlinear parabolic system
Lan QIAO; Sining ZHENG
2008-01-01
This paper deals with asymptotic analysis of a parabolic system with inner absorptions and coupled nonlinear boundary fluxes. Three simultaneous blow-up rates are established under different dominations of nonlinearities, and simply represented in a characteristic algebraic system introduced for the problem. In particular, it is observed that two of the multiple blow-up rates are absorption-related. This is substantially different from those for nonlinear parabolic problems with absorptions in all the previous literature, where the blow-up rates were known as absorption-independent. The results of the paper rely on the scaling method with a complete classification for the nonlinear parameters of the model. The first example of absorption-related blow-up rates was recently proposed by the authors for a coupled parabolic system with mixed type nonlinearities. The present paper shows that the newly observed phenomena of absorption-related blow-up rates should be due to the coupling mechanism, rather than the mixed type nonlinearities.
Irrigation market for solar-thermal parabolic-dish systems
Habib-agahi, H.; Jones, S.C.
1981-09-01
The potential size of the onfarm-pumped irrigation market for solar thermal parabolic dish systems in seven high-insolation states is estimated. The study is restricted to the displacement of three specific fuels: gasoline, diesel and natural gas. A model was developed to estimate the optimal number of parabolic dish modules per farm based on the minimum cost mix of conventional and solar thermal energy required to meet irrigation needs. Results indicate that the near-term market for such systems depends not only on the type of crop and method of irrigation, but also on the optimal utilization of each added module, which in turn depends on the price of conventional fuel, real discount rate, marginal cost of the solar thermal power system, local insolation level and parabolic dish system efficiency. The study concludes that the potential market size for onfarm-pumped irrigation applications ranges from 101,000 modules when a 14% real discount rate is assumed to 220,000 modules when the real discount rate drops to 8%. Arizona, Kansas, Nebraska, New Mexico and Texas account for 98% of the total demand for this application, with the natural gas replacement market accounting for the largest segment (71%) of the total market.
Faye, Ibrahima; Seck, Diaraf
2009-01-01
In this paper we build models for short-term, mean-term and long-term dynamics of dune and megariple morphodynamics. They are models that are degenerated parabolic equations which are, moreover, singularly perturbed. We, then give an existence and uniqueness result for the short-term and mean-term models. This result is based on a time-space periodic solution existence result for degenerated parabolic equation that we set out. Finally the short-term model is homogenized.
A methodology for modeling barrier island storm-impact scenarios
Mickey, Rangley C.; Long, Joseph W.; Plant, Nathaniel G.; Thompson, David M.; Dalyander, P. Soupy
2017-02-16
A methodology for developing a representative set of storm scenarios based on historical wave buoy and tide gauge data for a region at the Chandeleur Islands, Louisiana, was developed by the U.S. Geological Survey. The total water level was calculated for a 10-year period and analyzed against existing topographic data to identify when storm-induced wave action would affect island morphology. These events were categorized on the basis of the threshold of total water level and duration to create a set of storm scenarios that were simulated, using a high-fidelity, process-based, morphologic evolution model, on an idealized digital elevation model of the Chandeleur Islands. The simulated morphological changes resulting from these scenarios provide a range of impacts that can help coastal managers determine resiliency of proposed or existing coastal structures and identify vulnerable areas within those structures.
In vitro models of the blood-brain barrier
Helms, Hans Christian Cederberg; Abbott, N Joan; Burek, Malgorzata
2016-01-01
components of plasma and xenobiotics. This "blood-brain barrier" function is a major hindrance for drug uptake into the brain parenchyma. Cell culture models, based on either primary cells or immortalized brain endothelial cell lines, have been developed, in order to facilitate in vitro studies of drug...
M. Mildner; J. Jin; L. Eckhart; S. Kezic; F. Gruber; C. Barresi; C. Stremnitzer; M. Buchberger; V. Mlitz; C. Ballaun; B. Sterniczky; D. Födinger; E. Tschachler
2010-01-01
Loss-of-function mutations in the filaggrin gene are associated with ichthyosis vulgaris and atopic dermatitis. To investigate the impact of filaggrin deficiency on the skin barrier, filaggrin expression was knocked down by small interfering RNA (siRNA) technology in an organotypic skin model in vit
Widyastutik Widyastutik
2017-07-01
Full Text Available The ASEAN and its dialogue partner countries agreed to reduce trade barriers in the services sector, one of which is sea transport services. The purpose of this study is to estimate the equivalent tax of non-tariff barriers in the sea transport services. Besides that, this study is going to analyze the economic impacts of the regulatory barriers elimination in the sea transport services of ASEAN and its dialogue partner countries. Using the gravity model, it can be identified that trade barriers of sea transport services sector of ASEAN and dialogue partner countries are still relatively high. Additionally, by adopting IC-IRTS model in Global CGE Model (GTAP, the simulation results show consistent results with the theory of pro-competitive effects. The greater gain from trade is obtained in the CGE model assuming IC-IRTS compared to PC-CRTS. China gains a greater benefit that is indicated by the highest increase in welfare and GDP followed by Japan and AustraliaDOI: 10.15408/sjie.v6i2.5279
Characterization of a novel brain barrier ex vivo insect-based P-glycoprotein screening model
Andersson, O.; Badisco, L.; Hansen, A. H.;
2014-01-01
In earlier studies insects were proposed as suitable models for vertebrate blood–brain barrier (BBB) permeability prediction and useful in early drug discovery. Here we provide transcriptome and functional data demonstrating the presence of a P-glycoprotein (Pgp) efflux transporter in the brain b...
Numerical modelling of wave overwash at low-crested sand barriers
Tuan, T.Q.
2005-01-01
In overwash beaches, response of a barrier profile as a whole to storm wave attacks can be distinguished into seaward and landward parts that are associated with two respective across-shore driving processes i.e. surge erosion, and overwash. Modeling of overwash relies heavily on the specification o
Advances in one-dimensional numerical breach modeling of sand barriers
Tuan, T.Q.; Verhagen, H.J.; Visser, P.J.
2006-01-01
A hydrodynamic numerical model is formulated to describe the breach erosion process of sandy barriers. The breach flow is based on the system of unsteady shallow water equations, which is solved using a robust upwind numerical approach in conjunction with the Finite Volume Method (FVM). The hydrauli
Rahmani, Meisam; Ahmadi, Mohammad Taghi; Abadi, Hediyeh Karimi Feiz; Saeidmanesh, Mehdi; Akbari, Elnaz; Ismail, Razali
2013-01-30
Recent development of trilayer graphene nanoribbon Schottky-barrier field-effect transistors (FETs) will be governed by transistor electrostatics and quantum effects that impose scaling limits like those of Si metal-oxide-semiconductor field-effect transistors. The current-voltage characteristic of a Schottky-barrier FET has been studied as a function of physical parameters such as effective mass, graphene nanoribbon length, gate insulator thickness, and electrical parameters such as Schottky barrier height and applied bias voltage. In this paper, the scaling behaviors of a Schottky-barrier FET using trilayer graphene nanoribbon are studied and analytically modeled. A novel analytical method is also presented for describing a switch in a Schottky-contact double-gate trilayer graphene nanoribbon FET. In the proposed model, different stacking arrangements of trilayer graphene nanoribbon are assumed as metal and semiconductor contacts to form a Schottky transistor. Based on this assumption, an analytical model and numerical solution of the junction current-voltage are presented in which the applied bias voltage and channel length dependence characteristics are highlighted. The model is then compared with other types of transistors. The developed model can assist in comprehending experiments involving graphene nanoribbon Schottky-barrier FETs. It is demonstrated that the proposed structure exhibits negligible short-channel effects, an improved on-current, realistic threshold voltage, and opposite subthreshold slope and meets the International Technology Roadmap for Semiconductors near-term guidelines. Finally, the results showed that there is a fast transient between on-off states. In other words, the suggested model can be used as a high-speed switch where the value of subthreshold slope is small and thus leads to less power consumption.
Monte Carlo study of single-barrier structure based on exclusion model full counting statistics
Chen Hua; Du Lei; Qu Cheng-Li; He Liang; Chen Wen-Hao; Sun Peng
2011-01-01
Different from the usual full counting statistics theoretical work that focuses on the higher order cumulants computation by using cumulant generating function in electrical structures, Monte Carlo simulation of single-barrier structure is performed to obtain time series for two types of widely applicable exclusion models, counter-flows model,and tunnel model. With high-order spectrum analysis of Matlab, the validation of Monte Carlo methods is shown through the extracted first four cumulants from the time series, which are in agreement with those from cumulant generating function. After the comparison between the counter-flows model and the tunnel model in a single barrier structure, it is found that the essential difference between them consists in the strictly holding of Pauli principle in the former and in the statistical consideration of Pauli principle in the latter.
M. G. Crandall
1999-07-01
Full Text Available We study existence of continuous weak (viscosity solutions of Dirichlet and Cauchy-Dirichlet problems for fully nonlinear uniformly elliptic and parabolic equations. Two types of results are obtained in contexts where uniqueness of solutions fails or is unknown. For equations with merely measurable coefficients we prove solvability of the problem, while in the continuous case we construct maximal and minimal solutions. Necessary barriers on external cones are also constructed.
Development of microfluidic cell culture devices towards an in vitro human intestinal barrier model
Tan, Hsih-Yin
folds that closely resembled the intestinal villi and formation of a tight barrier. Furthermore, the microelectrodes embedded in the microchip also allow real-time monitoring of the barrier integrity by means of measuring the trans-epithelial electrical resistance. Demonstrations of transport studies...... using different compounds on the in vitro human intestinal model in the microfluidic device showed comparable results with static cultures. In addition, a normal commensal intestinal bacteria, Escherichia coli (E. coli) was successfully co-cultured on the luminal surface of the cultured epithelium...
Piecewise-Planar Parabolic Reflectarray Antenna
Hodges, Richard; Zawadzki, Mark
2009-01-01
The figure shows a dual-beam, dualpolarization Ku-band antenna, the reflector of which comprises an assembly of small reflectarrays arranged in a piecewise- planar approximation of a parabolic reflector surface. The specific antenna design is intended to satisfy requirements for a wide-swath spaceborne radar altimeter, but the general principle of piecewise-planar reflectarray approximation of a parabolic reflector also offers advantages for other applications in which there are requirements for wideswath antennas that can be stowed compactly and that perform equally in both horizontal and vertical polarizations. The main advantages of using flat (e.g., reflectarray) antenna surfaces instead of paraboloidal or parabolic surfaces is that the flat ones can be fabricated at lower cost and can be stowed and deployed more easily. Heretofore, reflectarray antennas have typically been designed to reside on single planar surfaces and to emulate the focusing properties of, variously, paraboloidal (dish) or parabolic antennas. In the present case, one approximates the nominal parabolic shape by concatenating several flat pieces, while still exploiting the principles of the planar reflectarray for each piece. Prior to the conception of the present design, the use of a single large reflectarray was considered, but then abandoned when it was found that the directional and gain properties of the antenna would be noticeably different for the horizontal and vertical polarizations.
Evaluation of physical load of hand-rim wheelchair propulsion on barrier-free model courses
Hiroshi Ikeda
2010-07-01
Full Text Available The aim of this study was to examine the effect of sidewalk developments on the physical load of hand-rim wheelchair propulsion using a barrier-free model course. Non-wheelchair users performed wheelchair exercise tests and R–R interval time, discomfort rating, and postural changes of seating were measured. As a result, due to excessively heavy load on certain parts of the body during active propulsion on the sidewalk, it was shown that barrier-free developments did not lead to a reduction of physical load. The results suggest the importance of a well-balanced barrier-free sidewalk design that takes into account the individual character of the wheelchair user's seating posture and physical load at the time of maneuvering. In addition, it is shown that the reduction of physical load can be considered as an effective method of evaluation.
Island-dynamics model for mound formation: effect of a step-edge barrier.
Papac, Joe; Margetis, Dionisios; Gibou, Frederic; Ratsch, Christian
2014-08-01
We formulate and implement a generalized island-dynamics model of epitaxial growth based on the level-set technique to include the effect of an additional energy barrier for the attachment and detachment of atoms at step edges. For this purpose, we invoke a mixed, Robin-type, boundary condition for the flux of adsorbed atoms (adatoms) at each step edge. In addition, we provide an analytic expression for the requisite equilibrium adatom concentration at the island boundary. The only inputs are atomistic kinetic rates. We present a numerical scheme for solving the adatom diffusion equation with such a mixed boundary condition. Our simulation results demonstrate that mounds form when the step-edge barrier is included, and that these mounds steepen as the step-edge barrier increases.
Khusaini, N. S.; Ismail, A.; Rashid, A. A.
2016-02-01
This paper presents a preliminary study on the prominent barriers to lean manufacturing implementation in Malaysian Food and Beverages Industry. A survey was carried out to determine the most prominent barriers of lean manufacturing implementation that are currently being faced in this industry. The amount of barriers identified for this study is twenty seven. Out of 1309 available organizations, a total of 300 organizations have been randomly selected as respondents, and 53 organizations responded. From the variable map, the analysis shows that, the negative perception towards lean manufacturing top the list as the most agreeable barrier, while the technical barriers came after it. It can also be seen from the variable map that averagely, lack of vision and direction is the barrier that is being faced. Finally, this is perhaps the first attempt in investigating the prominent barriers to Lean Manufacturing implementation in Malaysian food and beverages industry using Rasch Model.
Interband magneto-spectroscopy in InSb square and parabolic quantum wells
Kasturiarachchi, T.; Edirisooriya, M.; Mishima, T. D.; Doezema, R. E.; Santos, M. B. [Homer L. Dodge Department of Physics and Astronomy and Center for Semiconductor Physics in Nanostructures, University of Oklahoma, Norman, Oklahoma 73019 (United States); Saha, D.; Pan, X.; Sanders, G. D.; Stanton, C. J. [Department of Physics, University of Florida, Gainesville, Florida 32611 (United States)
2015-06-07
We measure the magneto-optical absorption due to intersubband optical transitions between conduction and valence subband Landau levels in InSb square and parabolic quantum wells. InSb has the narrowest band gap (0.24 eV at low temperature) of the III–V semiconductors leading to a small effective mass (0.014 m{sub 0}) and a large g–factor (−51). As a result, the Landau level spacing is large at relatively small magnetic fields (<8 T), and one can observe spin-splitting of the Landau levels. We examine two structures: (i) a multiple-square-well structure and (ii) a structure containing multiple parabolic wells. The energies and intensities of the strongest features are well explained by a modified Pidgeon-Brown model based on an 8-band k•p model that explicitly incorporates pseudomorphic strain. The strain is essential for obtaining agreement between theory and experiment. While modeling the square well is relatively straight-forward, the parabolic well consists of 43 different layers of various thickness to approximate a parabolic potential. Agreement between theory and experiment for the parabolic well validates the applicability of the model to complicated structures, which demonstrates the robustness of our model and confirms its relevance for developing electronic and spintronic devices that seek to exploit the properties of the InSb band structure.
Breaching the skin barrier--insights from molecular simulation of model membranes.
Notman, Rebecca; Anwar, Jamshed
2013-02-01
Breaching the skin's barrier function by design is an important strategy for delivering drugs and vaccines to the body. However, while there are many proposed approaches for reversibly breaching the skin barrier, our understanding of the molecular processes involved is still rudimentary. Molecular simulation offers an unprecedented molecular-level resolution with an ability to reproduce molecular and bulk level properties. We review the basis of the molecular simulation methodology and give applications of relevance to the skin lipid barrier, focusing on permeation of molecules and chemical approaches for breaching the lipid barrier by design. The bulk kinetic model based on Fick's Law describing absorption of a drug through skin has been reconciled with statistical mechanical quantities such as the local excess chemical potential and local diffusion coefficient within the membrane structure. Applications of molecular simulation reviewed include investigations of the structure and dynamics of simple models of skin lipids, calculation of the permeability of molecules in simple model membranes, and mechanisms of action of the penetration enhancers, DMSO, ethanol and oleic acid. The studies reviewed illustrate the power and potential of molecular simulation to yield important physical insights, inform and rationalize experimental studies, and to predict structural changes, and kinetic and thermodynamic quantities. Copyright © 2012 Elsevier B.V. All rights reserved.
The Lattice and Thermal Radiation Conductivity of Thermal Barrier Coatings: Models and Experiments
Zhu, Dongming; Spuckler, Charles M.
2010-01-01
The lattice and radiation conductivity of ZrO2-Y2O3 thermal barrier coatings was evaluated using a laser heat flux approach. A diffusion model has been established to correlate the coating apparent thermal conductivity to the lattice and radiation conductivity. The radiation conductivity component can be expressed as a function of temperature, coating material scattering, and absorption properties. High temperature scattering and absorption of the coating systems can be also derived based on the testing results using the modeling approach. A comparison has been made for the gray and nongray coating models in the plasma-sprayed thermal barrier coatings. The model prediction is found to have a good agreement with experimental observations.
Random perturbations of nonlinear parabolic systems
Beck, Lisa
2011-01-01
Several aspects of regularity theory for parabolic systems are investigated under the effect of random perturbations. The deterministic theory, when strict parabolicity is assumed, presents both classes of systems where all weak solutions are in fact more regular, and examples of systems with weak solutions which develop singularities in finite time. Our main result is the extension of a regularity result due to Kalita to the stochastic case. Concerning the examples with singular solutions (outside the setting of Kalita's regularity result), we do not know whether stochastic noise may prevent the emergence of singularities, as it happens for easier PDEs. We can only prove that, for a linear stochastic parabolic system with coefficients outside the previous regularity theory, the expected value of the solution is not singular.
Parabolic flight as a spaceflight analog.
Shelhamer, Mark
2016-06-15
Ground-based analog facilities have had wide use in mimicking some of the features of spaceflight in a more-controlled and less-expensive manner. One such analog is parabolic flight, in which an aircraft flies repeated parabolic trajectories that provide short-duration periods of free fall (0 g) alternating with high-g pullout or recovery phases. Parabolic flight is unique in being able to provide true 0 g in a ground-based facility. Accordingly, it lends itself well to the investigation of specific areas of human spaceflight that can benefit from this capability, which predominantly includes neurovestibular effects, but also others such as human factors, locomotion, and medical procedures. Applications to research in artificial gravity and to effects likely to occur in upcoming commercial suborbital flights are also possible. Copyright © 2016 the American Physiological Society.
Vijay Narayanan
2015-06-01
Full Text Available The purpose of this article is to understand the barriers faced by small and medium-sized enterprises in their path to internationalization. The intention of this paper is to provide an overview about the barriers faced by SMEs in their path to internationalization and discuss in detail different approaches taken by SMEs to overcome these barriers. This article is a literature review on the barriers faced by SMEs in internationalization and new approaches in this domain based on Leonidou’s (1995, 1998, 2004 model of export barrier classification. Modern approaches by SMEs are effective in handling most of the traditional challenges posed in internationalization. Firms have evolved in handling internal barriers by finding dynamic solutions from within. SMEs need support from governmental and policy makers to overcome external barriers. Indications on the work to be done in overcoming certain barriers which impede the internationalization of SMEs are more in the context of external barriers. The originality of this work is in creating a framework of barriers and finding solutions to some of the identified barriers.
Parabolic non-diffracting beams: geometrical approach
Sosa-Sánchez, Citlalli Teresa; Silva-Ortigoza, Gilberto; Alejandro Juárez-Reyes, Salvador; de Jesús Cabrera-Rosas, Omar; Espíndola-Ramos, Ernesto; Julián-Macías, Israel; Ortega-Vidals, Paula
2017-08-01
The aim of this work is to present a geometrical characterization of parabolic non-diffracting beams. To this end, we compute the corresponding angular spectrum of the separable non-diffracting parabolic beams in order to determine the one-parameter family of solutions of the eikonal equation associated with this type of beam. Using this information, we compute the corresponding wavefronts and caustic, and find that qualitatively the caustic corresponds to the maximum of the intensity pattern and the wavefronts are deformations of conical surfaces.
Controllable parabolic-cylinder optical rogue wave.
Zhong, Wei-Ping; Chen, Lang; Belić, Milivoj; Petrović, Nikola
2014-10-01
We demonstrate controllable parabolic-cylinder optical rogue waves in certain inhomogeneous media. An analytical rogue wave solution of the generalized nonlinear Schrödinger equation with spatially modulated coefficients and an external potential in the form of modulated quadratic potential is obtained by the similarity transformation. Numerical simulations are performed for comparison with the analytical solutions and to confirm the stability of the rogue wave solution obtained. These optical rogue waves are built by the products of parabolic-cylinder functions and the basic rogue wave solution of the standard nonlinear Schrödinger equation. Such rogue waves may appear in different forms, as the hump and paw profiles.
Asymptotical Properties for Parabolic Systems of Neutral Type
CUI Bao-tong; HAN Mao-an
2005-01-01
Asymptotical properties for the solutions of neutral parabolic systems with Robin boundary conditions were analyzed by using the inequality analysis. The oscillations problems for the neutral parabolic systems were considered and some oscillation criteria for the systems were established.
Langton, C.; Kosson, D.
2009-11-30
Cementitious barriers for nuclear applications are one of the primary controls for preventing or limiting radionuclide release into the environment. At the present time, performance and risk assessments do not fully incorporate the effectiveness of engineered barriers because the processes that influence performance are coupled and complicated. Better understanding the behavior of cementitious barriers is necessary to evaluate and improve the design of materials and structures used for radioactive waste containment, life extension of current nuclear facilities, and design of future nuclear facilities, including those needed for nuclear fuel storage and processing, nuclear power production and waste management. The focus of the Cementitious Barriers Partnership (CBP) literature review is to document the current level of knowledge with respect to: (1) mechanisms and processes that directly influence the performance of cementitious materials (2) methodologies for modeling the performance of these mechanisms and processes and (3) approaches to addressing and quantifying uncertainties associated with performance predictions. This will serve as an important reference document for the professional community responsible for the design and performance assessment of cementitious materials in nuclear applications. This review also provides a multi-disciplinary foundation for identification, research, development and demonstration of improvements in conceptual understanding, measurements and performance modeling that would be lead to significant reductions in the uncertainties and improved confidence in the estimating the long-term performance of cementitious materials in nuclear applications. This report identifies: (1) technology gaps that may be filled by the CBP project and also (2) information and computational methods that are in currently being applied in related fields but have not yet been incorporated into performance assessments of cementitious barriers. The various
Paving the way towards complex blood-brain barrier models using pluripotent stem cells
Lauschke, Karin; Frederiksen, Lise; Hall, Vanessa Jane
2017-01-01
to the unique tightness and selective permeability of the BBB and has been shown to be disrupted in many diseases and brain disorders, such as, vascular dementia, stroke, multiple sclerosis and Alzheimer's disease. Given the progress that pluripotent stem cells (PSCs) have made in the last two decades......A tissue with great need to be modelled in vitro is the blood-brain barrier (BBB). The BBB is a tight barrier that covers all blood vessels in the brain and separates the brain microenvironment from the blood system. It consists of three cell types (neurovascular unit (NVU)) that contribute......, it is now possible to produce many cell types from the BBB and even partially recapitulate this complex tissue in vitro. In this review, we summarize the most recent developments in PSC differentiation and modelling of the BBB. We also suggest how patient-specific human induced PSCs could be used to model...
Structure-based modelling in reproductive toxicology: (Q)SARs for the placental barrier.
Hewitt, M; Madden, J C; Rowe, P H; Cronin, M T D
2007-01-01
The replacement of animal testing for endpoints such as reproductive toxicity is a long-term goal. This study describes the possibilities of using simple (quantitative) structure-activity relationships ((Q)SARs) to predict whether a molecule may cross the placental membrane. The concept is straightforward, if a molecule is not able to cross the placental barrier, then it will not be a reproductive toxicant. Such a model could be placed at the start of any integrated testing strategy. To develop these models the literature was reviewed to obtain data relating to the transfer of molecules across the placenta. A reasonable number of data were obtained and are suitable for the modelling of the ability of a molecule to cross the placenta. Clearance or transfer indices data were sought due to their ability to eliminate inter-placental variation by standardising drug clearance to the reference compound antipyrine. Modelling of the permeability data indicates that (Q)SARs with reasonable statistical fit can be developed for the ability of molecules to cross the placental barrier membrane. Analysis of the models indicates that molecular size, hydrophobicity and hydrogen-bonding ability are molecular properties that may govern the ability of a molecule to cross the placental barrier.
Computer aided FEA simulation of EN45A parabolic leaf spring
Krishan Kumar
2013-04-01
Full Text Available This paper describes computer aided finite element analysis of parabolic leaf spring. The present work is an improvement in design of EN45A parabolic leaf spring used by a light commercial automotive vehicle. Development of a leaf spring is a long process which requires lots of test to validate the design and manufacturing variables. A three-layer parabolic leaf spring of EN45A has been taken for this work. The thickness of leaves varies from center to the outer side following a parabolic pattern. These leaf springs are designed to become lighter, but also provide a much improved ride to the vehicle through a reduction on interleaf friction. The CAD modeling of parabolic leaf spring has been done in CATIA V5 and for analysis the model is imported in ANSYS-11 workbench. The finite element analysis (FEA of the leaf spring has been carried out by initially discretizing the model into finite number of elements and nodes and then applying the necessary boundary conditions. Maximum displacement, directional displacement, equivalent stress and weight of the assembly are the output targets of this analysis for comparison & validation of the work.
Curvilinear parabolic approximation for surface wave transformation with wave current interaction
Shi, Fengyan; Kirby, James T.
2005-04-01
The direct coordinate transformation method, which only transforms independent variables and retains Cartesian dependent variables, may not be an appropriate method for the purpose of simplifying the curvilinear parabolic approximation of the vector form of the wave-current equation given by Kirby [Higher-order approximations in the parabolic equation method for water waves, J. Geophys. Res. 91 (1986) 933-952]. In this paper, the covariant-contravariant tensor method is used for the curvilinear parabolic approximation. We use the covariant components of the wave number vector and contravariant components of the current velocity vector so that the derivation of the curvilinear equation closely follows the higher-order approximation in rectangular Cartesian coordinates in Kirby [Higher-order approximations in the parabolic equation method for water waves, J. Geophys. Res. 91 (1986) 933-952]. The resulting curvilinear equation can be easily implemented using the existing model structure and numerical schemes adopted in the Cartesian parabolic wave model [J.T. Kirby, R.A. Dalrymple, F. Shi, Combined Refraction/Diffraction Model REF/DIF 1, Version 2.6. Documentation and User's Manual, Research Report, Center for Applied Coastal Research, Department of Civil and Environmental Engineering, University of Delaware, Newark, 2004]. Several examples of wave simulations in curvilinear coordinate systems, including a case with wave-current interaction, are shown with comparisons to theoretical solutions or measurement data.
Parabolic equations and Feynman_Kac formula on general bounded domains
ZHANG; Gongqing
2001-01-01
［1］Berestycki, H., Nirenberg, L., Varadhan, S. V. R., The principal eigenvalue and maximum principle for second order elliptic operators in general domains, Comm. Pure and Appl. Math., 1994, 47: 47.［2］Chen, Y. Z., Alexandrov's maximum principle and Bony's maximum principle for parabolic equations, Acta Mathematica Applicae Sinica, 1985, 2: 309.［3］Dong, G. C., Nonlinear Second Order Partial Differential Equations, AMS Translations, Providence: AMS, 1991.［4］Krylov, N. V., Nonlinear Elliptic and Parabolic Equations of Second Order, Mathematics and Its Applications, Dordrecht: D. Reidel Publication Company, 1987.［5］Tso, K. S., On the Alexandrov_Bakel'man type maximum principle for second order parabolic equations, Comm. PDE, 1985, 10: 543.［6］Miller, K., Barriers on cones for uniformly elliptic operators, Ann. Mat. Pura e Appl., 1967, 76: 93.［7］Strook, D., Varadhan, S. V. R., Multidimensional Diffusion Process, New York, Berlin: Springer_Verlag, 1979.［8］Pinsky, R. G., Positive Harmonic Functions and Diffusions, Cambridge: Cambridge University Press, 1995.［9］Friedman, A., Partial Differential Equations of Parabolic Type, Englewood Cliffs: Prentice_Hall Inc., 1964.
A NEWTON MULTIGRID METHOD FOR QUASILINEAR PARABOLIC EQUATIONS
YU Xijun
2005-01-01
A combination of the classical Newton Method and the multigrid method, i.e.,a Newton multigrid method is given for solving quasilinear parabolic equations discretized by finite elements. The convergence of the algorithm is obtained for only one step Newton iteration per level. The asymptotically computational cost for quasilinear parabolic problems is O(NNk) similar to multigrid method for linear parabolic problems.
A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development
Sugimoto Masahiko
2010-07-01
Full Text Available Abstract Background Development and maintenance of the blood-brain and blood-retinal barrier is critical for the homeostasis of brain and retinal tissue. Despite decades of research our knowledge of the formation and maintenance of the blood-brain (BBB and blood-retinal (BRB barrier is very limited. We have established an in vivo model to study the development and maintenance of these barriers by generating a transgenic zebrafish line that expresses a vitamin D-binding protein fused with enhanced green fluorescent protein (DBP-EGFP in blood plasma, as an endogenous tracer. Results The temporal establishment of the BBB and BRB was examined using this transgenic line and the results were compared with that obtained by injection of fluorescent dyes into the sinus venosus of embryos at various stages of development. We also examined the expression of claudin-5, a component of tight junctions during the first 4 days of development. We observed that the BBB of zebrafish starts to develop by 3 dpf, with expression of claudin-5 in the central arteries preceding it at 2 dpf. The hyaloid vasculature in the zebrafish retina develops a barrier function at 3 dpf, which endows the zebrafish with unique advantages for studying the BRB. Conclusion Zebrafish embryos develop BBB and BRB function simultaneously by 3 dpf, which is regulated by tight junction proteins. The Tg(l-fabp:DBP-EGFP zebrafish will have great advantages in studying development and maintenance of the blood-neural barrier, which is a new application for the widely used vertebrate model.
郭苏; 刘德有; 张耀明; 许昌; 王沛
2014-01-01
直接蒸汽发电(direct steam generation，DSG)槽式太阳能热发电系统的集热器长度一般很长，且具有明显的分布参数特征。因此，建立DSG槽式太阳能集热器的非线性分布参数模型，以DSG集热器入口工质温度、质量流量和出口压力为边界条件，采用迎风格式的有限差分法对模型进行离散求解。仿真研究了DSG集热器主要参数在太阳辐射强度、给水温度和给水流量变化等扰动工况下的响应特性，结果与文献实验结果基本一致，验证了模型的正确性。结果表明：太阳辐射强度降低时，出口工质温度下降得很快；给水流量或给水温度小幅下降时，出口工质温度和流量都会滞后响应且变化显著；DSG 集热器出口工质流量在某些情况下会发生脉动，实际应用中应避免脉动状态的发生或降低其影响。%Direct steam generation (DSG) in parabolic trough solar power system has long solar collector and obvious distributed parameter characteristics. Therefore, a nonlinear distributed parameter model for parabolic trough DSG solar collectors was built in this paper. As a boundary condition, fluid temperature and mass flow had to be provided at the inlet as well as the pressure at the outlet, and the finite differential approach with an upwind scheme was adopted to discrete and solve the model. Compared with experimental results from the literature, the correctness of the model was validated by simulation results during the main conditions such as solar radiation intensity, inlet fluid temperature and inlet mass flow change. Simulation results show that fluid temperature at the outlet decreases quickly when solar radiation intensity is declined; Furthermore, the responses of fluid temperature and mass flow at the outlet delay largely and stabilize slowly when mass flow or temperature at the inlet declined slightly; Most significantly, a pulsation phenomenon of outlet mass flow may happen
A Bayesian Chance-Constrained Method for Hydraulic Barrier Design Under Model Structure Uncertainty
Chitsazan, N.; Pham, H. V.; Tsai, F. T. C.
2014-12-01
The groundwater community has widely recognized the model structure uncertainty as the major source of model uncertainty in groundwater modeling. Previous studies in the aquifer remediation design, however, rarely discuss the impact of the model structure uncertainty. This study combines the chance-constrained (CC) programming with the Bayesian model averaging (BMA) as a BMA-CC framework to assess the effect of model structure uncertainty in the remediation design. To investigate the impact of the model structure uncertainty on the remediation design, we compare the BMA-CC method with the traditional CC programming that only considers the model parameter uncertainty. The BMA-CC method is employed to design a hydraulic barrier to protect public supply wells of the Government St. pump station from saltwater intrusion in the "1,500-foot" sand and the "1-700-foot" sand of the Baton Rouge area, southeastern Louisiana. To address the model structure uncertainty, we develop three conceptual groundwater models based on three different hydrostratigraphy structures. The results show that using the traditional CC programming overestimates design reliability. The results also show that at least five additional connector wells are needed to achieve more than 90% design reliability level. The total amount of injected water from connector wells is higher than the total pumpage of the protected public supply wells. While reducing injection rate can be achieved by reducing reliability level, the study finds that the hydraulic barrier design to protect the Government St. pump station is not economically attractive.
Chernoff's distribution and parabolic partial differential equations
P. Groeneboom; S.P. Lalley; N.M. Temme (Nico)
2013-01-01
textabstractWe give an alternative route to the derivation of the distribution of the maximum and the location of the maximum of one-sided and two-sided Brownian motion with a negative parabolic drift, using the Feynman-Kac formula with stopping times. The derivation also uses an interesting
Orbit Connections in a Parabolic Equation.
1983-04-01
Departamento de Matematica , 13560, Slo Carlos, S.P. Brasil. This research has been supported in part by CAPES-qoordena~io de Aperfeiqoamento de Pessoal...de Nivel Superior , Brasilia, D.F., Brasil under contract Proc. #3056/78. 1k ORBIT CONNECTIONS IN A PARABOLIC EQUATION by Jack K. Hale and Arnaldo S
Stokes' theorem, volume growth and parabolicity
Valtorta, Daniele
2010-01-01
We present some new Stokes'type theorems on complete non-compact manifolds that extend, in different directions, previous work by Gaffney and Karp and also the so called Kelvin-Nevanlinna-Royden criterion for (p-)parabolicity. Applications to comparison and uniqueness results involving the p-Laplacian are deduced.
CONTINUOUS DEPENDENCE FOR A BACKWARD PARABOLIC PROBLEM
刘继军
2003-01-01
We consider a backward parabolic problem arising in the description of the behavior of the toroidal part of the magenetic field in a dynamo problem. In our backward time problem, the media parameters are spatial distributed and the boundary conditions are of the Robin type. For this ill-posed problem, we prove that the solution depends continuously on the initial-time geometry.
Discontinuous mixed covolume methods for parabolic problems.
Zhu, Ailing; Jiang, Ziwen
2014-01-01
We present the semidiscrete and the backward Euler fully discrete discontinuous mixed covolume schemes for parabolic problems on triangular meshes. We give the error analysis of the discontinuous mixed covolume schemes and obtain optimal order error estimates in discontinuous H(div) and first-order error estimate in L(2).
An Approximation of Ultra-Parabolic Equations
Allaberen Ashyralyev
2012-01-01
Full Text Available The first and second order of accuracy difference schemes for the approximate solution of the initial boundary value problem for ultra-parabolic equations are presented. Stability of these difference schemes is established. Theoretical results are supported by the result of numerical examples.
ANISOTROPIC PARABOLIC EQUATIONS WITH MEASURE DATA
Li Fengquan; Zhao Huixiu
2001-01-01
In this paper, we prove the existence of solutions to anisotropic parabolic equations with right hand side term in the bounded Radon measure M(Q) and the initial condition in M(Ω) or in Lm space (with m "small").
Chernoff's distribution and parabolic partial differential equations
P. Groeneboom; S.P. Lalley; N.M. Temme (Nico)
2013-01-01
textabstractWe give an alternative route to the derivation of the distribution of the maximum and the location of the maximum of one-sided and two-sided Brownian motion with a negative parabolic drift, using the Feynman-Kac formula with stopping times. The derivation also uses an interesting relatio
Modeling of asymmetric pulsed phenomena in dielectric-barrier atmospheric-pressure glow discharges
Ha Yan [College of Mathematics and Computer Science, Hebei University, Baoding 071002 (China); Wang Huijuan [School of Mathematics and Physics, North China Electric Power University, Baoding 071003 (China); Wang Xiaofei [College of Physics Science and Technology, Hebei University, Baoding 071002 (China)
2012-01-15
Asymmetric current pulses in dielectric-barrier atmospheric-pressure glow discharges are investigated by a self-consistent, one-dimensional fluid model. It is found that the glow mode and Townsend mode can coexist in the asymmetric discharge even though the gas gap is rather large. The reason for this phenomenon is that the residual space charge plays the role of anode and reduces the gap width, resulting in the formation of a Townsend discharge.
Models for estimation of service life of concrete barriers in low-level radioactive waste disposal
Walton, J.C.; Plansky, L.E.; Smith, R.W. (EG and G Idaho, Inc., Idaho Falls, ID (USA))
1990-09-01
Concrete barriers will be used as intimate parts of systems for isolation of low level radioactive wastes subsequent to disposal. This work reviews mathematical models for estimating the degradation rate of concrete in typical service environments. The models considered cover sulfate attack, reinforcement corrosion, calcium hydroxide leaching, carbonation, freeze/thaw, and cracking. Additionally, fluid flow, mass transport, and geochemical properties of concrete are briefly reviewed. Example calculations included illustrate the types of predictions expected of the models. 79 refs., 24 figs., 6 tabs.
Analyzing Parabolic Profile Path for Underwater Towed-Cable
Vineet KSrivastava
2014-01-01
This article discusses the dynamic state analysis of underwater towed-cable when tow-ship changes its speed in a direction making parabolic profile path. A three-dimensional model of underwater towed system is studied. The established governing equations for the system have been solved using the central implicit finite-difference method. The obtained difference non-linear coupled equations are solved by Newton’s method and satisfactory results were achieved. The solution of this problem has practical importance in the estimation of dynamic loading and motion, and hence it is directly applicable to the enhancement of safety and the effectiveness of the offshore activities.
Limits of Femtosecond Fiber Amplification by Parabolic Pre-Shaping
Fu, Walter; McComb, Timothy S; Lowder, Tyson L; Wise, Frank W
2016-01-01
We explore parabolic pre-shaping as a means of generating and amplifying ultrashort pulses. We develop a theoretical framework for modeling the technique and use its conclusions to design a femtosecond fiber amplifier. Starting from 9 ps pulses, we obtain 4.3 $\\mu$J, nearly transform-limited pulses 275 fs in duration, simultaneously achieving over 40 dB gain and 33-fold compression. Finally, we show that this amplification scheme is limited by Raman scattering, and outline a method by which the pulse duration and energy may be further improved and tailored for a given application.
Limits of Femtosecond Fiber Amplification by Parabolic Pre-Shaping.
Fu, Walter; Tang, Yuxing; McComb, Timothy S; Lowder, Tyson L; Wise, Frank W
2017-03-01
We explore parabolic pre-shaping as a means of generating and amplifying ultrashort pulses. We develop a theoretical framework for modeling the technique and use its conclusions to design a femtosecond fiber amplifier. Starting from 9 ps pulses, we obtain 4.3 μJ, nearly transform-limited pulses 275 fs in duration, simultaneously achieving over 40 dB gain and 33-fold compression. Finally, we show that this amplification scheme is limited by Raman scattering, and outline a method by which the pulse duration and energy may be further improved and tailored for a given application.
Investigating the barrier function of skin lipid models with varying compositions.
Groen, Daniël; Poole, Dana S; Gooris, Gert S; Bouwstra, Joke A
2011-10-01
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the barrier function. The main lipid classes in stratum corneum are ceramides, cholesterol, and free fatty acids. In previous publications, a lipid model was presented, referred to as the stratum corneum substitute (SCS), that closely mimics the SC lipid organization and SC barrier function. In the present study, we use the SCS to study the effect of changes in lipid organization on the lipid barrier function using benzoic acid as permeation compound. First, in the SCS, we increased the level of one of the three major lipid classes keeping the ratio between the other lipid classes constant. An increased cholesterol level resulted in an increase in phase-separated cholesterol and a reduction in the permeability. An increase in ceramide or free fatty acid level resulted in the formation of additional phases, but had no significant influence on the permeability. We also examined models that mimic selected changes in lipid composition reported for dry or diseased skin. The SCS that mimics the composition in recessive X-linked ichthyosis skin displayed a twofold increase in permeability. This increase is possibly related to the formation of an additional, less ordered phase in this model. Copyright © 2011 Elsevier B.V. All rights reserved.
Novel models for studying the blood-brain and blood-eye barriers in Drosophila.
Pinsonneault, Robert L; Mayer, Nasima; Mayer, Fahima; Tegegn, Nebiyu; Bainton, Roland J
2011-01-01
In species as varied as humans and flies, humoral/central nervous system barrier structures are a major obstacle to the passive penetration of small molecules including endogenous compounds, environmental toxins, and drugs. In vivo measurement of blood-brain physiologic function in vertebrate animal models is difficult and current ex vivo models for more rapid experimentation using, for example, cultured brain endothelial cells, only partially reconstitute the anatomy and physiology of a fully intact blood-brain barrier (BBB). To address these problems, we and others continue to develop in vivo assays for studying the complex physiologic function of central nervous system (CNS) barriers using the fruit fly Drosophila melanogaster (Dm). These methods involve the introduction of small molecule reporters of BBB physiology into the fly humoral compartment by direct injection. Since these reporters must cross the Dm BBB in order to be visible in the eye, we can directly assess genetic or chemical modulators of BBB function by monitoring retinal fluorescence. This assay has the advantage of utilizing a physiologically intact BBB in a model organism that is economical and highly amenable to genetic manipulation. In combination with other approaches outlined here, such as brain dissection and behavioral assessment, one can produce a fuller picture of BBB biology and physiology. In this chapter, we provide detailed methods for examining BBB biology in the fly, including a Dm visual assay to screen for novel modulators of the BBB.
Fusion Barrier of Super-heavy Elements in a Generalized Liquid Drop Model
CHENBao-Qiu; MAZhong-Yu
2004-01-01
The macroscopic deformed potential energies for super-heavy elements Z = 110,112,114,116,118 arc determined within a generalized liquid drop model (GLDM). A quasi-molecular mechanism is introduced to describe the deformation of a nucleus in the GLDM and the shell model simultaneously. The macroscopic energy of a twocenter nuclear system in the GLDM includes the volume-, surface-, and Coulomb-energies, the proximity effect at each mass asymmetry, and accurate nuclear radius. The shell correction is calculated by the Strutinsky method and the microscopic single particle energies are derived from a shell model in an axially deformed Woods-Saxon potential with the quasi-molecular shape. The total potential energy of a nucleus can be calculated by the macro-microscopic method as the summation of the liquid-drop energy and the Strutinsky shell correction. The theory is applied to predict the fusion barriers of the cold reactions 64Ni + 208 spb → 272 110*, 70Zn + 208pb → 278 112*, 76Ge + 208seb → 284 114*,82Se + 208pb → 29 116*, 86Kr + 208pb → 294 118*. It is found that the neck in the quasi-molecular shape is responsible for the deep valley of the fusion barrier. In the cold fusion path, double-hump fusion barriers could be predicted by the shell corrections and complete fusion events may occur.
Fusion Barrier of Super-heavy Elements in a Generalized Liquid Drop Model
CHEN Bao-Qiu; MA Zhong-Yu
2004-01-01
The macroscopic deformed potential energies for super-heavy elements Z = 110,112,114,116,118 are determined within a generalized liquid drop model (GLDM). A quasi-molecular mechanism is introduced to describe the deformation of a nucleus in the GLDM and the shell model simultaneously. The macroscopic energy of a twocenter nuclear system in the GLDM includes the volume-, surface-, and Coulomb-energies, the proximity effect at each mass asymmetry, and accurate nuclear radius. The shell correction is calculated by the Strutinsky method and the microscopic single particle energies are derived from a shell model in an axially deformed Woods-Saxon potential with the quasi-molecular shape. The total potential energy of a nucleus can be calculated by the macro-microscopic method as the summation of the liquid-drop energy and the Strutinsky shell correction. The theory is applied to predict the fusion barriers of the cold reactions 64Ni + 208Pb → 272110*, 70Zn + 208Pb → 278112*, 76Ge + 208pb → 284114*,82Se + 208Pb → 290116*, 86Kr + 208Pb → 294118*. It is found that the neck in the quasi-molecular shape is responsible for the deep valley of the fusion barrier. In the cold fusion path, double-hump fusion barriers could be predicted by the shell corrections and complete fusion events may occur.
Banadaki, Yaser M.; Srivastava, Ashok
2015-09-01
The performance of graphene nanoribbon field effect transistor (GNR FET) is investigated from a numerical model based on self-consistent non-equilibrium Green's Function (NEGF) formulism in mode-space with position-dependent effective mass model and tight-binding model. The model accounts for the tunneling currents on the static performance of GNR FETs in two semiconducting families of armchair GNRs (3p,0) and (3p+1,0). We conclude that increasing the GNR width in both GNR families increases the leakage current and subthreshold swing, and decreases ION/IOFF ratio. In this scenario, GNR group (3p+1,0) leads to superior off-state performance such that GNR (7,0) has off-state current close to 2.5 × 10-16 A, five orders of magnitude lower than GNR (6,0) as well as 67 mV/decade subthreshold swing which is much smaller than that of 90 mV/decade in GNR (6,0).
Thermal and optical efficiency investigation of a parabolic trough collector
C. Tzivanidis
2015-09-01
Full Text Available Solar energy utilization is a promising Renewable Energy source for covering a variety of energy needs of our society. This study presents the most well-known solar concentrating system, the parabolic trough collector, which is operating efficiently in high temperatures. The simulation tool of this analysis is the commercial software Solidworks which simulates complicated problems with an easy way using the finite elements method. A small parabolic trough collector model is designed and simulated for different operating conditions. The goal of this study is to predict the efficiency of this model and to analyze the heat transfer phenomena that take place. The efficiency curve is compared to a one dimensional numerical model in order to make a simple validation. Moreover, the temperature distribution in the absorber and inside the tube is presented while the heat flux distribution in the outer surface of the absorber is given. The heat convection coefficient inside the tube is calculated and compared with the theoretical one according to the literature. Also the angle efficiency modifier is calculated in order to predict the thermal and optical efficiency for different operating conditions. The final results show that the PTC model performs efficiently and all the calculations are validated.
A parabolic velocity-decomposition method for wind turbines
Mittal, Anshul; Briley, W. Roger; Sreenivas, Kidambi; Taylor, Lafayette K.
2017-02-01
An economical parabolized Navier-Stokes approximation for steady incompressible flow is combined with a compatible wind turbine model to simulate wind turbine flows, both upstream of the turbine and in downstream wake regions. The inviscid parabolizing approximation is based on a Helmholtz decomposition of the secondary velocity vector and physical order-of-magnitude estimates, rather than an axial pressure gradient approximation. The wind turbine is modeled by distributed source-term forces incorporating time-averaged aerodynamic forces generated by a blade-element momentum turbine model. A solution algorithm is given whose dependent variables are streamwise velocity, streamwise vorticity, and pressure, with secondary velocity determined by two-dimensional scalar and vector potentials. In addition to laminar and turbulent boundary-layer test cases, solutions for a streamwise vortex-convection test problem are assessed by mesh refinement and comparison with Navier-Stokes solutions using the same grid. Computed results for a single turbine and a three-turbine array are presented using the NREL offshore 5-MW baseline wind turbine. These are also compared with an unsteady Reynolds-averaged Navier-Stokes solution computed with full rotor resolution. On balance, the agreement in turbine wake predictions for these test cases is very encouraging given the substantial differences in physical modeling fidelity and computer resources required.
盛楠; 廖成; 张青洪; 陈伶璐; 周海京
2014-01-01
雾是影响毫米波通信系统性能的典型气象条件之一。针对传统经验模型无法精确预测多径效应下的电波传播问题，给出了基于抛物方程的雾衰减预测模型。以自由空间雾特征衰减的预测为例，将本文模型与Rayleigh近似及经验模型的计算结果进行对比，验证了该方法的可靠性。最后将该模型应用于预测35 GHz和94 GHz毫米波在分别含有平流雾和辐射雾的复杂环境中的传播特性，仿真结果表明该模型有效地反映了地形绕射、地表反射等对电波传播的影响，为快速准确地预测复杂地理环境及特殊气象条件中的电波传播特性提供了一种有效的预测模型。%Fog is one of the crucial factors in determining the performance of millimeter-wave communication systems .Be-cause of the fact that the multipath propagation is not be taken into account by the traditional empirical formulae ,this paper devel-oped a parabolic equation model for estimating fog attenuation .The fog attenuation rate predicted by the model agrees well with that obtained by the Rayleigh approximation and an empirical formula ,which verify the accuracy of our method .Finally ,the model is applied to simulate the propagation characteristics of millimeter-wave at frequency of 35 GHz and 94 GHz in Advection fog and Ra-diation fog with complex environments ,respectively .The results demonstrate that the model can take account of wave diffraction and reflection ,and thus our scheme provides an efficient numerical method for computation of the propagation characteristics of millime-ter-wave in complex environments .
Barrier Lyapunov function-based model-free constraint position control for mechanical systems
Han, Seong Ik; Ha, Hyun Uk; Lee, Jang Myung [Pusan National University, Busan (Korea, Republic of)
2016-07-15
In this article, a motion constraint control scheme is presented for mechanical systems without a modeling process by introducing a barrier Lyapunov function technique and adaptive estimation laws. The transformed error and filtered error surfaces are defined to constrain the motion tracking error in the prescribed boundary layers. Unknown parameters of mechanical systems are estimated using adaptive laws derived from the Lyapunov function. Then, robust control used the conventional sliding mode control, which give rise to excessive chattering, is changed to finite time-based control to alleviate undesirable chattering in the control action and to ensure finite-time error convergence. Finally, the constraint controller from the barrier Lyapunov function is designed and applied to the constraint of the position tracking error of the mechanical system. Two experimental examples for the XY table and articulated manipulator are shown to evaluate the proposed control scheme.
Barriers and strategies to an iterative model of advance care planning communication.
Ahluwalia, Sangeeta C; Bekelman, David B; Huynh, Alexis K; Prendergast, Thomas J; Shreve, Scott; Lorenz, Karl A
2015-12-01
Early and repeated patient-provider conversations about advance care planning (ACP) are now widely recommended. We sought to characterize barriers and strategies for realizing an iterative model of ACP patient-provider communication. A total of 2 multidisciplinary focus groups and 3 semistructured interviews with 20 providers at a large Veterans Affairs medical center. Thematic analysis was employed to identify salient themes. Barriers included variation among providers in approaches to ACP, lack of useful information about patient values to guide decision making, and ineffective communication between providers across settings. Strategies included eliciting patient values rather than specific treatment choices and an increased role for primary care in the ACP process. Greater attention to connecting providers across the continuum, maximizing the potential of the electronic health record, and linking patient experiences to their values may help to connect ACP communication across the continuum. © The Author(s) 2014.
Modelling of safety barriers including human and organisational factors to improve process safety
Markert, Frank; Duijm, Nijs Jan; Thommesen, Jacob
2013-01-01
explosion, and the Mont Blanc Tunnel Fire, such an approach may have helped to maintain the integrity of the designed provisions against major deviations resulting in these disasters. In order to make this paradigm operational, safety management and in particular risk assessment tools need to be refined....... A valuable approach is the inclusion of human and organisational factors into the simulation of the reliability of the technical system using event trees and fault trees and the concept of safety barriers. This has been demonstrated e.g. in the former European research project ARAMIS (Accidental Risk...... Assessment Methodology for IndustrieS, see Salvi et al 2006). ARAMIS employs the bow-tie approach to modelling hazardous scenarios, and it suggests the outcome of auditing safety management to be connected to a semi-quantitative assessment of the quality of safety barriers. ARAMIS discriminates a number...
Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier
Tornabene, Erica; Brodin, Birger
2016-01-01
Stroke is a major cause of death and disability worldwide. Both cerebral hypoperfusion and focal cerebral infarcts are caused by a reduction of blood flow to the brain, leading to stroke and subsequent brain damage. At present, only few medical treatments of stroke are available, with the Food...... and Drug Administration-approved tissue plasminogen activator for treatment of acute ischemic stroke being the most prominent example. A large number of potential drug candidates for treatment of ischemic brain tissue have been developed and subsequently failed in clinical trials. A deeper understanding...... of permeation pathways across the barrier in ischemic and postischemic brain endothelium is important for development of new medical treatments. The blood-brain barrier, that is, the endothelial monolayer lining the brain capillaries, changes properties during an ischemic event. In vitro models of the blood-brain...
[Innovative health care models in Germany - success factors, barriers and transferability].
Müller, Beate S; Leiferman, Mareike; Wilke, Dennis; Gerlach, Ferdinand M; Erler, Antje
2016-10-01
Safeguarding country-wide health care in Germany requires innovative ideas: a shortage of skilled staff among medical professionals and in long-term care on the one hand contrasts with an increasing number of multi-morbid elderly patients on the other hand. In the "Innovative Health Care Models" project sponsored by the Robert Bosch Foundation a nationwide status review and systematization of innovative approaches to health care was conducted, along with an analysis of the factors that promote or hinder the implementation of a health care model, and a study of the conditions that must be satisfied if successful concepts are to be transferred to other regions. After identifying innovative and successfully implemented health care models, data on success factors and barriers for implementation as well as data on conditions of their transferability to other regions were collected during structured telephone interviews and entered into a specifically developed database. Content analysis was used to qualitatively evaluate the interviews. Interviews with 65 representatives of successfully implemented models with differing organizational structures and priorities were conducted and evaluated. Success factors and barriers were most obvious in the fields of leadership, readiness to participate, relational aspects, personality traits, cooperation and communication, resources and organizational and structural factors. Various regionally linked health care concepts already exist throughout Germany. The barriers, success factors and conditions influencing the transferability of a model to other regions are largely independent of the type of organization. The success of a model is determined by adequate personal and financial resources, sound organizational structures and external support from political and funding bodies. Copyright © 2016. Published by Elsevier GmbH.
Wen-ku Shi; Cheng Liu; Zhi-yong Chen; Wei He; Qing-hua Zu
2016-01-01
The composite stiffness of parabolic leaf springs with variable stiffness is difficult to calculate using traditional integral equations. Numerical integration or FEA may be used but will require computer-aided software and long calculation times. An efficient method for calculating the composite stiffness of parabolic leaf springs with variable stiffness is developed and evaluated to reduce the complexity of calculation and shorten the calculation time. A simplified model for double-leaf spr...
Oliveri, Alberto; Stocchino, Alessandro; Storace, Marco
2011-03-01
Understanding mixing processes that occur in the human vitreous chamber is of fundamental importance due to the relevant clinical implications in drug delivery treatments of several eye conditions. In this article we rely on experimental observations (which demonstrated that dispersion coefficients largely dominate diffusive coefficients) on a physical model of the human eye to perform an analysis based on Lagrangian trajectories. In particular, we study barriers to transport in a particularly significant two-dimensional section of the eye model by using nonlinear dynamical systems theoretical and numerical tools. Bifurcations in the system dynamics are investigated by varying the main physical parameters of the problem.
Schottky barrier height in metal-SiC contact - new approach to modelling
Ivanov, P.A.; Ignat`ev, K.I. [Ioffe Physico-Technical Inst., St. Petersburg (Russian Federation)
1998-08-01
A new approach to calculate Schottky barrier height in a metal-SiC contact is proposed proceeding from uniform spatial distribution of electron traps within metal-to-SiC gap represented by native oxide. The model explains well experimental data on metal-6H-SiC contacts, with comparatively low mid-gap surface state density. This is in contrast with widely used analytical model by Cowley and Sze providing high interface state density at the 6H-SiC mid-gap. (orig.) 5 refs.
Model predictive control for nonlinear parabolic system using wavelet base%基于小波基的非线性抛物型系统模型预测控制
艾岭
2015-01-01
针对一类由非线性抛物型描述的分布参数系统，研究了一种基于小波分解的模型降阶和预测控制方法。利用小波配点方法，分别将一阶和二阶空间偏导数投影到拟Shannon小波基上，不需要求解系统的主导极点，得到系统的低阶常微分方程逼近模型；采用前向Eular方法离散化时间变量，将得到的差分方程组模型作为系统的预测模型，选择标准二次优化性能指标，设计相应的非线性预测控制器；将此方法应用到由一个放置在反应器中的细长催化棒组成的传输-反应系统的温度场控制问题中，取得了满意的控制效果。%For a class of nonlinear parabolic distributed parameter systems, model reduction and predic-tive control method were investigated. First, the first order and second order spatial partial derivative were projected to quasi-Shannon wavelet using wavelet collocation method respectively, eliminating the need of knowledge of solution of dominant pole of the system. The correspondent lower order model was obtained. A group of ordinary differential equations obtained through Eular’ s discretizing time variable was selected as the predictive model of the system, standard quadratic optimization performance index was selected, and the corresponding nonlinear predictive controller was designed. This method was applied to the transfer-reaction system of catalytic rod, and simulation results indicate that the proposed method meets the requirements of system control.
Two parabolic equations for propagation in layered poro-elastic media.
Metzler, Adam M; Siegmann, William L; Collins, Michael D; Collis, Jon M
2013-07-01
Parabolic equation methods for fluid and elastic media are extended to layered poro-elastic media, including some shallow-water sediments. A previous parabolic equation solution for one model of range-independent poro-elastic media [Collins et al., J. Acoust. Soc. Am. 98, 1645-1656 (1995)] does not produce accurate solutions for environments with multiple poro-elastic layers. First, a dependent-variable formulation for parabolic equations used with elastic media is generalized to layered poro-elastic media. An improvement in accuracy is obtained using a second dependent-variable formulation that conserves dependent variables across interfaces between horizontally stratified layers. Furthermore, this formulation expresses conditions at interfaces using no depth derivatives higher than first order. This feature should aid in treating range dependence because convenient matching across interfaces is possible with discretized derivatives of first order in contrast to second order.
Ramirez, A L; Daily, W D
2003-11-21
We have performed a numerical modeling study that evaluated the capacity of electrical resistance tomography (ERT) to detect flaws in a passive reactive barrier (PRB). The model barrier is based on a real barrier described in the literature Slater and Binley (2003). It consists of highly conducting, granular iron emplaced within a trench. We assumed that the barrier was filled with a mixture of iron and sand, and that vertical electrode arrays were embedded within the barrier. We have considered (a) characterization and (b) monitoring scenarios. For (a), the objective is to use tomographs of absolute resistivity to detect construction flaws and inhomogeneities in iron distribution shortly after installation. For (b), the objective is to use resistivity change tomographs to detect iron oxidation and barrier plugging as a function of time. The study considered varying PRB hole sizes and locations. For any given model, a hole was located right next to and near the center of an electrode array (maximum sensitivity and resolution expected), at the center between two electrode arrays (moderate sensitivity and resolution), or near the bottom centered between the two arrays (minimum sensitivity and resolution). We also considered various hole sizes. The smallest hole considered had a height and a width of 0.33 m (0.11 m{sup 2}), or 1/2 of the electrode spacing within an array; the depth of the hole was always equal to the thickness of the barrier (0.66m). The largest hole had a height and a width of 1.22 m (1.74 m{sup 2}). We also modeled a medium sized hole with a height and a width of 0.66 m (0.44 m{sup 2}). The PRB material had an electrical resistivity of 0.3 ohm-m (sand/iron mix) while the hole's resistivity was 3.0 ohm-m. The study also considered various array aspect ratios because it is well known that aspect ratio controls sensitivity and resolution when line arrays of electrodes are used (Ramirez et al., 1993). Aspect ratio is defined as the distance between
Zhang, B.; Chen, Kuiying; Baddour, N.; Patnaik, P. C.
2017-06-01
The failure analysis and life prediction of atmospheric plasma-sprayed thermal barrier coatings (APS-TBCs) were carried out for a thermal cyclic process. A residual stress model for the top coat of APS-TBC was proposed and then applied to life prediction. This residual stress model shows an inversion characteristic versus thickness of thermally grown oxide. The capability of the life model was demonstrated using temperature-dependent model parameters. Using existing life data, a comparison of fitting approaches of life model parameters was performed. A larger discrepancy was found for the life predicted using linearized fitting parameters versus temperature compared to those using non-linear fitting parameters. A method for integrating the residual stress was proposed by using the critical time of stress inversion. The role of the residual stresses distributed at each individual coating layer was explored and their interplay on the coating's delamination was analyzed.
Distribution-valued weak solutions to a parabolic problem arising in financial mathematics
Michael Eydenberg
2009-07-01
Full Text Available We study distribution-valued solutions to a parabolic problem that arises from a model of the Black-Scholes equation in option pricing. We give a minor generalization of known existence and uniqueness results for solutions in bounded domains $Omega subset mathbb{R}^{n+1}$ to give existence of solutions for certain classes of distributions $fin mathcal{D}'(Omega$. We also study growth conditions for smooth solutions of certain parabolic equations on $mathbb{R}^nimes (0,T$ that have initial values in the space of distributions.
Pal, U. N.; Kumar, M.; Tyagi, M. S.; Meena, B. L.; Khatun, H.; Sharma, A. K.
2010-02-01
Dielectric-barrier discharges (DBDs) are characterized by the presence of at least one insulating layer in contact with the discharge between two planar or cylindrical electrodes connected to an AC/pulse power supply. The dielectric layers covering the electrodes act as current limiters and prevent the transition to an arc discharge. DBDs exist usually in filamentary mode, based on the streamer nature of the discharges. The main advantage of this type of electrical discharges is that nonequilibrium and non-thermal plasma conditions can be established at atmospheric pressure. VUV/UV sources based on DBDs are considered as promising alternatives of conventional mercury-based discharge plasmas, producing highly efficient VUV/UV radiation. The experiments have been performed using two coaxial quartz double barrier DBD tubes, which are filled with Xe/Ar at different pressures. A sinusoidal voltage up to 2.4 kV peak with frequencies from 20 to 100 kHz has been applied to the discharge electrodes for the generation of microdischarges. A stable and uniform discharge is produced in the gas gap between the dielectric barrier electrodes. By comparisons of visual images and electrical waveforms, the filamentary discharges for Ar tube while homogeneous discharge for Xe tube at the same conditions have been confirmed. The electrical modeling has been carried out to understand DBD phenomenon in variation of applied voltage waveforms. The simulated discharge characteristics have been validated by the experimental results.
Gonzalez-Andrades, Miguel; Alonso-Pastor, Luis; Mauris, Jérôme; Cruzat, Andrea; Dohlman, Claes H; Argüeso, Pablo
2016-01-13
The repair of wounds through collective movement of epithelial cells is a fundamental process in multicellular organisms. In stratified epithelia such as the cornea and skin, healing occurs in three steps that include a latent, migratory, and reconstruction phases. Several simple and inexpensive assays have been developed to study the biology of cell migration in vitro. However, these assays are mostly based on monolayer systems that fail to reproduce the differentiation processes associated to multilayered systems. Here, we describe a straightforward in vitro wound assay to evaluate the healing and restoration of barrier function in stratified human corneal epithelial cells. In this assay, circular punch injuries lead to the collective migration of the epithelium as coherent sheets. The closure of the wound was associated with the restoration of the transcellular barrier and the re-establishment of apical intercellular junctions. Altogether, this new model of wound healing provides an important research tool to study the mechanisms leading to barrier function in stratified epithelia and may facilitate the development of future therapeutic applications.
Random free energy barrier hopping model for ac conduction in chalcogenide glasses
Murti, Ram; Tripathi, S. K.; Goyal, Navdeep; Prakash, Satya
2016-03-01
The random free energy barrier hopping model is proposed to explain the ac conductivity (σac) of chalcogenide glasses. The Coulomb correlation is consistently accounted for in the polarizability and defect distribution functions and the relaxation time is augmented to include the overlapping of hopping particle wave functions. It is observed that ac and dc conduction in chalcogenides are due to same mechanism and Meyer-Neldel (MN) rule is the consequence of temperature dependence of hopping barriers. The exponential parameter s is calculated and it is found that s is subjected to sample preparation and measurement conditions and its value can be less than or greater than one. The calculated results for a - Se, As2S3, As2Se3 and As2Te3 are found in close agreement with the experimental data. The bipolaron and single polaron hopping contributions dominates at lower and higher temperatures respectively and in addition to high energy optical phonons, low energy optical and high energy acoustic phonons also contribute to the hopping process. The variations of hopping distance with temperature is also studied. The estimated defect number density and static barrier heights are compared with other existing calculations.
Barriers and facilitators for establishing eating habits, "Póngale Vida®" model
Ana Raquel Gómez-Alpízar
2015-12-01
Full Text Available Introduction: The Preschool Cycle is a period of changes in nutritional status and eating behavior, constituting a fundamental stage for the development of healthy eating habits, where the family plays a major role. Objective: Identify the main barriers and facilitators for healthy eating in preschool age, with the purpose of designing strategies to prevent childhood overweight and obesity. Materials and Methods: The research was conducted under a mixed approach, with a descriptive and transversal type. Sixty parents or caregivers of preschool children who were part of the model during 2014 at the Mariano Cortés School (urban and Canada School (rural, completed the questionnaire and twenty-five participated in the focus groups (one focus group in each school. Results: The barriers that the parents and caregivers faced daily included: food rejection by the child, the influence of peers and even the attitudes of adults who share with the child while eating. The facilitators that encourage healthy eating in this stage of life were: establish clear rules when eating, offer a variety of foods and explain to the child the importance of eating fruits and vegetables in a simple way. Conclusion: The barriers and facilitators to promote healthy eating in this stage of the lifetime, must be include as part of future strategies for the prevention of childhood obesity.
Gharbieh, Heidar K., E-mail: heidar.gharbieh@tu-clausthal.de [Institute of Disposal Research, Clausthal University of Technology, Clausthal-Zellerfeld (Germany); Cota, Stela, E-mail: sdsc@cdtn.br [Centro de Desenvolvimento da Tecnologia Nucelar (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)
2015-07-01
Narrow diameter borehole facilities (a few tens of centimeters), like the BOSS concept developed by the IAEA, provide a safe and cost effective disposal option for radioactive waste and particularly disused sources. The BOSS concept (borehole disposal of sealed radioactive sources) comprises a multi-barrier system of cement grout and stainless steel components. In order to predict the long-time performance of the cement barriers as an input of a future safety assessment under the specific hydrochemical and hydrological conditions, a non-linear degradation model was developed in this work. With the assistance of the program 'PHREEQC' it describes the change of the porosity and the hydraulic conductivity with time, which also let to conclusions concerning the change of the sorption capacity of the cement grout. This work includes the theoretical approach and illustrates the non-liner degradation by means of an exemplary water composition found in the saturated zone and the dimensions of the backfill made of cement grout representing a barrier of the BOSS borehole facility. (author)
Positive solutions of quasilinear parabolic systems with nonlinear boundary conditions
Pao, C. V.; Ruan, W. H.
2007-09-01
The aim of this paper is to investigate the existence, uniqueness, and asymptotic behavior of solutions for a coupled system of quasilinear parabolic equations under nonlinear boundary conditions, including a system of quasilinear parabolic and ordinary differential equations. Also investigated is the existence of positive maximal and minimal solutions of the corresponding quasilinear elliptic system as well as the uniqueness of a positive steady-state solution. The elliptic operators in both systems are allowed to be degenerate in the sense that the density-dependent diffusion coefficients Di(ui) may have the property Di(0)=0 for some or all i. Our approach to the problem is by the method of upper and lower solutions and its associated monotone iterations. It is shown that the time-dependent solution converges to the maximal solution for one class of initial functions and it converges to the minimal solution for another class of initial functions; and if the maximal and minimal solutions coincide then the steady-state solution is unique and the time-dependent solution converges to the unique solution. Applications of these results are given to three model problems, including a porous medium type of problem, a heat-transfer problem, and a two-component competition model in ecology. These applications illustrate some very interesting distinctive behavior of the time-dependent solutions between density-independent and density-dependent diffusions.
Positive solutions of quasilinear parabolic systems with Dirichlet boundary condition
Pao, C. V.; Ruan, W. H.
Coupled systems for a class of quasilinear parabolic equations and the corresponding elliptic systems, including systems of parabolic and ordinary differential equations are investigated. The aim of this paper is to show the existence, uniqueness, and asymptotic behavior of time-dependent solutions. Also investigated is the existence of positive maximal and minimal solutions of the corresponding quasilinear elliptic system. The elliptic operators in both systems are allowed to be degenerate in the sense that the density-dependent diffusion coefficients D(u) may have the property D(0)=0 for some or all i=1,…,N, and the boundary condition is u=0. Using the method of upper and lower solutions, we show that a unique global classical time-dependent solution exists and converges to the maximal solution for one class of initial functions and it converges to the minimal solution for another class of initial functions; and if the maximal and minimal solutions coincide then the steady-state solution is unique and the time-dependent solution converges to the unique solution. Applications of these results are given to three model problems, including a scalar polynomial growth problem, a coupled system of polynomial growth problem, and a two component competition model in ecology.
Parabolic dish collectors - A solar option
Truscello, V. C.
1981-01-01
A description is given of several parabolic-dish high temperature solar thermal systems currently undergoing performance trials. A single parabolic dish has the potential for generating 20 to 30 kW of electricity with fluid temperatures from 300 to 1650 C. Each dish is a complete power-producing unit, and may function either independently or as part of a group of linked modules. The two dish designs under consideration are of 11 and 12 meter diameters, yielding receiver operating temperatures of 925 and 815 C, respectively. The receiver designs described include (1) an organic working fluid (toluene) Rankine cycle engine; (2) a Brayton open cycle unit incorporating a hybrid combustion chamber and nozzle and a shaft-coupled permanent magnet alternator; and (3) a modified Stirling cycle device originally designed for automotive use. Also considered are thermal buffer energy storage and thermochemical transport and storage.
Who dares to join a parabolic flight?
Montag, Christian; Zander, Tina; Schneider, Stefan
2016-12-01
Parabolic flights represent an important tool in space research to investigate zero gravity on airplanes. Research on these flights often target psychological and biological processes in humans to investigate if and how we can adapt to this unique environment. This research is costly, hard to conduct and clearly heavily relies on humans participating in experiments in this (unnatural) situation. The present study investigated N =66 participants and N =66 matched control persons to study if participants in such experimental flights differ in terms of their personality traits from non-parabonauts. The main finding of this study demonstrates that parabonauts score significantly lower on harm avoidance, a trait closely linked to being anxious. As anxious humans differ from non-anxious humans in their biology, the present observations need to be taken into account when aiming at the generalizability of psychobiological research findings conducted in zero gravity on parabolic flights.
Antiperiodic Problems for Nonautonomous Parabolic Evolution Equations
R. N. Wang
2014-01-01
Full Text Available This work focuses on the antiperiodic problem of nonautonomous semilinear parabolic evolution equation in the form u′(t=A(tu(t+f(t,u(t, t∈R, u(t+T=-u(t, t∈R, where (Att∈R (possibly unbounded, depending on time, is a family of closed and densely defined linear operators on a Banach space X. Upon making some suitable assumptions such as the Acquistapace and Terreni conditions and exponential dichotomy on (Att∈R, we obtain the existence results of antiperiodic mild solutions to such problem. The antiperiodic problem of nonautonomous semilinear parabolic evolution equation of neutral type is also considered. As sample of application, these results are applied to, at the end of the paper, an antiperiodic problem for partial differential equation, whose operators in the linear part generate an evolution family of exponential stability.
Moving interfaces and quasilinear parabolic evolution equations
Prüss, Jan
2016-01-01
In this monograph, the authors develop a comprehensive approach for the mathematical analysis of a wide array of problems involving moving interfaces. It includes an in-depth study of abstract quasilinear parabolic evolution equations, elliptic and parabolic boundary value problems, transmission problems, one- and two-phase Stokes problems, and the equations of incompressible viscous one- and two-phase fluid flows. The theory of maximal regularity, an essential element, is also fully developed. The authors present a modern approach based on powerful tools in classical analysis, functional analysis, and vector-valued harmonic analysis. The theory is applied to problems in two-phase fluid dynamics and phase transitions, one-phase generalized Newtonian fluids, nematic liquid crystal flows, Maxwell-Stefan diffusion, and a variety of geometric evolution equations. The book also includes a discussion of the underlying physical and thermodynamic principles governing the equations of fluid flows and phase transitions...
Raymond Derk
2015-03-01
Full Text Available Pulmonary barrier function plays a pivotal role in protection from inhaled particles. However, some nano-scaled particles, such as carbon nanotubes (CNT, have demonstrated the ability to penetrate this barrier in animal models, resulting in an unusual, rapid interstitial fibrosis. To delineate the underlying mechanism and specific bio-effect of inhaled nanoparticles in respiratory toxicity, models of lung epithelial barriers are required that allow accurate representation of in vivo systems; however, there is currently a lack of consistent methods to do so. Thus, this work demonstrates a well-characterized in vitro model of pulmonary barrier function using Calu-3 cells, and provides the experimental conditions required for achieving tight junction complexes in cell culture, with trans-epithelial electrical resistance measurement used as a biosensor for proper barrier formation and integrity. The effects of cell number and serum constituents have been examined and we found that changes in each of these parameters can greatly affect barrier formation. Our data demonstrate that use of 5.0 × 104 Calu-3 cells/well in the Transwell cell culture system, with 10% serum concentrations in culture media is optimal for assessing epithelial barrier function. In addition, we have utilized CNT exposure to analyze the dose-, time-, and nanoparticle property-dependent alterations of epithelial barrier permeability as a means to validate this model. Such high throughput in vitro cell models of the epithelium could be used to predict the interaction of other nanoparticles with lung epithelial barriers to mimic respiratory behavior in vivo, thus providing essential tools and bio-sensing techniques that can be uniformly employed.
Transfer of opiorphin through a blood-brain barrier culture model.
Bocsik, Alexandra; Darula, Zsuzsanna; Tóth, Géza; Deli, Mária A; Wollemann, Mária
2015-08-01
Opioid peptides are potent analgesics with therapeutic potential in the treatment of acute and chronic pain. Their efficacy is limited by peptidases (enkephalinases). Opiorphin pentapeptide (QRFSR) is the first characterized human endogenous inhibitor of enkephalinases. The peptide is able to increase the binding and affinity of endogenous opiates to mu opioid receptors; thus, the mechanism of opiorphin may provide a new therapeutic approach in pain management. The analgesic effect of opiorphin was proven in several earlier published in vitro and in vivo studies. Our aim was to test the transfer of opiorphin through a blood-brain barrier model for the first time. The flux of opiorphin was tested on a blood-brain barrier culture model consisting of rat brain endothelial, glial and pericyte cells. Brain endothelial cells in this triple co-culture model form tight monolayers characterized by transendothelial electrical resistance measurement. Relative quantity of the peptide was estimated by mass spectrometry. The transfer of opiorphin through the blood-brain barrier model was estimated to be ∼3%, whereas the permeability coefficient was 0.53 ± 1.36 × 10(-6) cm/s (n = 4). We also observed rapid conversion of N-terminal glutamine into pyroglutamic acid during the transfer experiments. Our results indicate that opiorphin crosses cultured brain endothelial cells in the absence of serum factors in a significant amount. This is in agreement with previous in vivo data showing potentiation of enkephalin-mediated antinociception. We suggest that opiorphin may have a potential as a centrally acting novel drug to treat pain.
A short proof of increased parabolic regularity
Stephen Pankavich
2015-08-01
Full Text Available We present a short proof of the increased regularity obtained by solutions to uniformly parabolic partial differential equations. Though this setting is fairly introductory, our new method of proof, which uses a priori estimates and an inductive method, can be extended to prove analogous results for problems with time-dependent coefficients, advection-diffusion or reaction diffusion equations, and nonlinear PDEs even when other tools, such as semigroup methods or the use of explicit fundamental solutions, are unavailable.
Building a parabolic solar concentrator prototype
Escobar-Romero, J F M; Montiel, S Vazquez y; Granados-AgustIn, F; Rodriguez-Rivera, E; Martinez-Yanez, L [INAOE, Luis Enrique Erro 1, Tonantzintla, Pue., 72840 (Mexico); Cruz-Martinez, V M, E-mail: jfmescobar@yahoo.com [Universidad Tecnologica de la Mixteca, Camino a Acatilma Km 2.5, Huajuapan de Leon, Oax., 69000 (Mexico)
2011-01-01
In order to not further degrade the environment, people have been seeking to replace non-renewable natural resources such as fossil fuels by developing technologies that are based on renewable resources. An example of these technologies is solar energy. In this paper, we show the building and test of a solar parabolic concentrator as a prototype for the production of steam that can be coupled to a turbine to generate electricity or a steam engine in any particular industrial process.
Parabolic cylinder functions of large order
Jones, D. S.
2006-06-01
The asymptotic behaviour of parabolic cylinder functions of large real order is considered. Various expansions in terms of elementary functions are derived. They hold uniformly for the variable in appropriate parts of the complex plane. Some of the expansions are doubly asymptotic with respect to the order and the complex variable which is an advantage for computational purposes. Error bounds are determined for the truncated versions of the asymptotic series.
INVERSE COEFFICIENT PROBLEMS FOR PARABOLIC HEMIVARIATIONAL INEQUALITIES
Liu Zhenhai; I.Szántó
2011-01-01
This paper is devoted to the class of inverse problems for a nonlinear parabolic hemivariational inequality.The unknown coefficient of the operator depends on the gradient of the solution and belongs to a set of admissible coefficients.It is proved that the convergence of solutions for the corresponding direct problems continuously depends on the coefficient convergence.Based on this result the existence of a quasisolution of the inverse problem is obtained.
Controllability of nonlinear degenerate parabolic cascade systems
Mamadou Birba
2016-08-01
Full Text Available This article studies of null controllability property of nonlinear coupled one dimensional degenerate parabolic equations. These equations form a cascade system, that is, the solution of the first equation acts as a control in the second equation and the control function acts only directly on the first equation. We prove positive null controllability results when the control and a coupling set have nonempty intersection.
Lifanov, Yuri; Vorselaars, Bart; Quigley, David
2016-12-01
We study a three-species analogue of the Potts lattice gas model of nucleation from solution in a regime where partially disordered solute is a viable thermodynamic phase. Using a multicanonical sampling protocol, we compute phase diagrams for the system, from which we determine a parameter regime where the partially disordered phase is metastable almost everywhere in the temperature-fugacity plane. The resulting model shows non-trivial nucleation and growth behaviour, which we examine via multidimensional free energy calculations. We consider the applicability of the model in capturing the multi-stage nucleation mechanisms of polymorphic biominerals (e.g., CaCO3). We then quantitatively explore the kinetics of nucleation in our model using the increasingly popular "seeding" method. We compare the resulting free energy barrier heights to those obtained via explicit free energy calculations over a wide range of temperatures and fugacities, carefully considering the propagation of statistical error. We find that the ability of the "seeding" method to reproduce accurate free energy barriers is dependent on the degree of supersaturation, and severely limited by the use of a nucleation driving force Δμ computed for bulk phases. We discuss possible reasons for this in terms of underlying kinetic assumptions, and those of classical nucleation theory.
Parabolic resection for mitral valve repair.
Drake, Daniel H; Drake, Charles G; Recchia, Dino
2010-02-01
Parabolic resection, named for the shape of the cut edges of the excised tissue, expands on a common 'trick' used by experienced mitral surgeons to preserve tissue and increase the probability of successful repair. Our objective was to describe and clinically analyze this simple modification of conventional resection. Thirty-six patients with mitral regurgitation underwent valve repair using parabolic resection in combination with other techniques. Institution specific mitral data, Society of Thoracic Surgeons data and preoperative, post-cardiopulmonary bypass (PCPB) and postoperative echocardiography data were collected and analyzed. Preoperative echocardiography demonstrated mitral regurgitation ranging from moderate to severe. PCPB transesophageal echocardiography demonstrated no regurgitation or mild regurgitation in all patients. Thirty-day surgical mortality was 2.8%. Serial echocardiograms demonstrated excellent repair stability. One patient (2.9%) with rheumatic disease progressed to moderate regurgitation 33 months following surgery. Echocardiography on all others demonstrated no or mild regurgitation at a mean follow-up of 22.8+/-12.8 months. No patient required mitral reintervention. Longitudinal analysis demonstrated 80% freedom from cardiac death, reintervention and greater than moderate regurgitation at four years following repair. Parabolic resection is a simple technique that can be very useful during complex mitral reconstruction. Early and intermediate echocardiographic studies demonstrate excellent results.
Modelling of the Peltier effect in magnetic multilayers
Juarez-Acosta, I.; Olivares-Robles, M. A.; Bosu, S.; Sakuraba, Y.; Kubota, T.; Takahashi, S; Takanashi, K.; Bauer, G. E. W.
2016-01-01
We model the charge, spin, and heat currents in ferromagnetic metal$|$normal metal$|$normal metal trilayer structures in the two current model, taking into account bulk and interface thermoelectric properties as well as Joule heating. Results include the temperature distribution as well as resistance-current curves that reproduce the observed shifted parabolic characteristics. Thin tunneling barriers can enhance the apparent Peltier cooling. The model agrees with experimental results for wide...
Laura Fanea
2012-01-01
Full Text Available Neurological disorders represent major causes of lost years of healthy life and mortality worldwide. Development of their quantitative interdisciplinary in vivo evaluation is required. Compartment modeling (CM of brain data acquired in vivo using magnetic resonance imaging techniques with clinically available contrast agents can be performed to quantitatively assess brain perfusion. Transport of 1H spins in water molecules across physiological compartmental brain barriers in three different pools was mathematically modeled and theoretically evaluated in this paper and the corresponding theoretical compartment modeling of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI data was analyzed. The pools considered were blood, tissue, and cerebrospinal fluid (CSF. The blood and CSF data were mathematically modeled assuming continuous flow of the 1H spins in these pools. Tissue data was modeled using three CMs. Results in this paper show that transport across physiological brain barriers such as the blood to brain barrier, the extracellular space to the intracellular space barrier, or the blood to CSF barrier can be evaluated quantitatively. Statistical evaluations of this quantitative information may be performed to assess tissue perfusion, barriers' integrity, and CSF flow in vivo in the normal or disease-affected brain or to assess response to therapy.
Reactive transport modeling has been conducted to describe the performance of the permeable reactive barrier at the Coast Guard Support Center near Elizabeth City, NC. The reactive barrier was installed to treat groundwater contaminated by hexavalent chromium and chlorinated org...
On a Parabolic-Elliptic system with chemotaxis and logistic type growth
Galakhov, Evgeny; Salieva, Olga; Tello, J. Ignacio
2016-10-01
We consider a nonlinear PDEs system of two equations of Parabolic-Elliptic type with chemotactic terms. The system models the movement of a biological population "u" towards a higher concentration of a chemical agent "w" in a bounded and regular domain Ω ⊂RN for arbitrary N ∈ N. After normalization, the system is as follows
Compound parabolic concentrator optical fiber tip for FRET-based fluorescent sensors
Hassan, Hafeez Ul; Nielsen, Kristian; Aasmul, Soren
2015-01-01
The Compound Parabolic Concentrator (CPC) optical fiber tip shape has been proposed for intensity based fluorescent sensors working on the principle of FRET (Förster Resonance Energy Transfer). A simple numerical Zemax model has been used to optimize the CPC tip geometry for a step-index multimod...
A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.
Romeo Cecchelli
Full Text Available The human blood brain barrier (BBB is a selective barrier formed by human brain endothelial cells (hBECs, which is important to ensure adequate neuronal function and protect the central nervous system (CNS from disease. The development of human in vitro BBB models is thus of utmost importance for drug discovery programs related to CNS diseases. Here, we describe a method to generate a human BBB model using cord blood-derived hematopoietic stem cells. The cells were initially differentiated into ECs followed by the induction of BBB properties by co-culture with pericytes. The brain-like endothelial cells (BLECs express tight junctions and transporters typically observed in brain endothelium and maintain expression of most in vivo BBB properties for at least 20 days. The model is very reproducible since it can be generated from stem cells isolated from different donors and in different laboratories, and could be used to predict CNS distribution of compounds in human. Finally, we provide evidence that Wnt/β-catenin signaling pathway mediates in part the BBB inductive properties of pericytes.
Spike-adding in parabolic bursters: The role of folded-saddle canards
Desroches, Mathieu; Krupa, Martin; Rodrigues, Serafim
2016-09-01
The present work develops a new approach to studying parabolic bursting, and also proposes a novel four-dimensional canonical and polynomial-based parabolic burster. In addition to this new polynomial system, we also consider the conductance-based model of the Aplysia R15 neuron known as the Plant model, and a reduction of this prototypical biophysical parabolic burster to three variables, including one phase variable, namely the Baer-Rinzel-Carillo (BRC) phase model. Revisiting these models from the perspective of slow-fast dynamics reveals that the number of spikes per burst may vary upon parameter changes, however the spike-adding process occurs in an explosive fashion that involves special solutions called canards. This spike-adding canard explosion phenomenon is analysed by using tools from geometric singular perturbation theory in tandem with numerical bifurcation techniques. We find that the bifurcation structure persists across all considered systems, that is, spikes within the burst are incremented via the crossing of an excitability threshold given by a particular type of canard orbit, namely the true canard of a folded-saddle singularity. However there can be a difference in the spike-adding transitions in parameter space from one case to another, according to whether the process is continuous or discontinuous, which depends upon the geometry of the folded-saddle canard. Using these findings, we construct a new polynomial approximation of the Plant model, which retains all the key elements for parabolic bursting, including the spike-adding transitions mediated by folded-saddle canards. Finally, we briefly investigate the presence of spike-adding via canards in planar phase models of parabolic bursting, namely the theta model by Ermentrout and Kopell.
A suction blister model reliably assesses skin barrier restoration and immune response.
Smith, Tracey J; Wilson, Marques A; Young, Andrew J; Montain, Scott J
2015-02-01
Skin wound healing models can be used to detect changes in immune function in response to interventions. This study used a test-retest format to assess the reliability of a skin suction blister procedure for quantitatively evaluating human immune function in repeated measures type studies. Up to eight suction blisters (~30 mm(2)) were induced via suction on each participant's left and right forearm (randomized order; blister session 1 and 2), separated by approximately one week. Fluid was sampled from each blister, and the top layer of each blister was removed to reveal up to eight skin wounds. Fluid from each wound was collected 4, 7 and 24h after blisters were induced, and proinflammatory cytokines were measured. Transepidermal water loss (TEWL), to assess skin barrier recovery, was measured daily at each wound site until values were within 90% of baseline values (i.e., unbroken skin). Sleep, stress and inflammation (i.e., factors that affect wound healing and immune function), preceding the blister induction, were assessed via activity monitors (Actical, Philips Respironics, Murrysville, Pennsylvania), the Perceived Stress Scale (PSS) and C-reactive protein (CRP), respectively. Area-under-the-curve and TEWL, between blister session 1 and 2, were compared using Pearson correlations and partial correlations (controlling for average nightly sleep, PSS scores and CRP). The suction blister method was considered reliable for assessing immune response and skin barrier recovery if correlation coefficients reached 0.7. Volunteers (n=16; 12 M; 4F) were 23 ± 5 years [mean ± SD]. Time to skin barrier restoration was 4.9 ± 0.8 and 4.8 ± 0.9 days for sessions 1 and 2, respectively. Correlation coefficients for skin barrier restoration, IL-6, IL-8 and MIP-1α were 0.9 (Pblister method is sufficiently reliable for assessing skin barrier restoration and immune responsiveness. This data can be used to determine sample sizes for cross-sectional or repeated-measures types of
One-equation modeling and validation of dielectric barrier discharge plasma actuator thrust
Yoon, Jae-San; Han, Jae-Hung
2014-10-01
Dielectric barrier discharge (DBD) plasma actuators with an asymmetric electrode configuration can generate a wall-bounded jet without mechanical moving parts, which require considerable modifications of existing aeronautical objects and which incur high maintenance costs. Despite this potential, one factor preventing the wider application of such actuators is the lack of a reliable actuator model. It is difficult to develop such a model because calculating the ion-electric field and fluid interaction consume a high amount calculation effort during the numerical analysis. Thus, the authors proposed a semi-empirical model which predicted the thrust of plasma actuators with a simple equation. It gave a numeric thrust value, and we implemented the value on a computational fluid dynamics (CFD) solver to describe the two-dimensional flow field induced by the actuator. However, the model had a narrow validation range, depending on the empirical formula, and it did not fully consider environment variables. This study presents an improved model by replacing the empirical formulae in the previous model with physical equations that take into account physical phenomena and environmental variables. During this process, additional operation parameters, such as pressure, temperature and ac waveforms, are newly taken to predict the thrust performance of the actuators with a wider range of existing parameters, the thickness of the dielectric barrier, the exposed electrode, the dielectric constant, the ac frequency and the voltage amplitude. Thrust prediction curves from the model are compared to those of earlier experimental results, showing that the average error is less than 5% for more than one hundred instances of data. As in the earlier work, the predicted thrust value is implemented on a CFD solver, and two-dimensional wall-jet velocity profiles induced by the actuator are compared to the previous experimental results.
Femtosecond parabolic pulse shaping in normally dispersive optical fibers.
Sukhoivanov, Igor A; Iakushev, Sergii O; Shulika, Oleksiy V; Díez, Antonio; Andrés, Miguel
2013-07-29
Formation of parabolic pulses at femtosecond time scale by means of passive nonlinear reshaping in normally dispersive optical fibers is analyzed. Two approaches are examined and compared: the parabolic waveform formation in transient propagation regime and parabolic waveform formation in the steady-state propagation regime. It is found that both approaches could produce parabolic pulses as short as few hundred femtoseconds applying commercially available fibers, specially designed all-normal dispersion photonic crystal fiber and modern femtosecond lasers for pumping. The ranges of parameters providing parabolic pulse formation at the femtosecond time scale are found depending on the initial pulse duration, chirp and energy. Applicability of different fibers for femtosecond pulse shaping is analyzed. Recommendation for shortest parabolic pulse formation is made based on the analysis presented.
Gidyk, Darryl C; Deibel, Scott H; Hong, Nancy S; McDonald, Robert J
2015-01-01
Sporadic Alzheimer's disease (AD) is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless studies have been conducted, however, the details of this disease remain largely unknown. Rodent models provide opportunities to investigate certain aspects of AD that cannot be studied in humans. These animal models vary from study to study and have provided some insight, but no real advancements in the prevention or treatment of the disease. In this Hypothesis and Theory paper, we discuss what we perceive as barriers to impactful discovery in rodent AD research and we offer potential solutions for moving forward. Although no single model of AD is capable of providing the solution to the growing epidemic of the disease, we encourage a comprehensive approach that acknowledges the complex etiology of AD with the goal of enhancing the bidirectional translatability from bench to bedside and vice versa.
Haralambous, Betty; Dow, Briony; Tinney, Jean; Lin, Xiaoping; Blackberry, Irene; Rayner, Victoria; Lee, Sook-Meng; Vrantsidis, Freda; Lautenschlager, Nicola; Logiudice, Dina
2014-03-01
The prevalence of dementia is increasing in Australia. Limited research is available on access to Cognitive Dementia and Memory Services (CDAMS) for people with dementia from Culturally and Linguistically Diverse (CALD) communities. This study aimed to determine the barriers and enablers to accessing CDAMS for people with dementia and their families of Chinese and Vietnamese backgrounds. Consultations with community members, community workers and health professionals were conducted using the "Cultural Exchange Model" framework. For carers, barriers to accessing services included the complexity of the health system, lack of time, travel required to get to services, language barriers, interpreters and lack of knowledge of services. Similarly, community workers and health professionals identified language, interpreters, and community perceptions as key barriers to service access. Strategies to increase knowledge included providing information via radio, printed material and education in community group settings. The "Cultural Exchange Model" enabled engagement with and modification of the approaches to meet the needs of the targeted CALD communities.
Tsong, Tian Yow; Chang, Cheng-Hung
2005-05-01
We examine a typical Michaelis-Menten Enzyme (MME) and redress it to form a transducer of free energy, and electric, acoustic, or other types of energy. This amendment and extension is necessary in lieu of recent experiments in which enzymes are shown to perform pump, motor, and locomotion functions resembling their macroscopic counterparts. Classical textbook depicts enzyme, or an MME, as biocatalyst which can enhance the rate of a chemical reaction by lowering the activation barrier but cannot shift the thermodynamic equilibrium of the biochemical reaction. An energy transducer, on the other hand, must also be able to harvest, store, or divert energy and in doing so alter the chemical equilibrium, change the energy form, fuel an energy consuming process, or perform all these functions stepwise in one catalytic turnover. The catalytic wheel presented in this communication is both a catalyst and an energy transducer and can perform all these tasks with ease. A Conformational Coupling Model for the rotary motors and a Barrier Surfing Model for the track-guided stepping motors and transporters, are presented and compared. It is shown that the core engine of the catalytic wheel, or a Brownian motor, is a Markovian engine. It remains to be seen if this core engine is the basic mechanism for a wide variety of bio-molecular energy transducers, as well as certain other dynamic systems, for example, the Parrondo's Games.
Bifurcation and stability for a nonlinear parabolic partial differential equation
Chafee, N.
1973-01-01
Theorems are developed to support bifurcation and stability of nonlinear parabolic partial differential equations in the solution of the asymptotic behavior of functions with certain specified properties.
Measurement of Liquid Viscosities in Tapered or Parabolic Capillaries.
Ershov; Zorin; Starov
1999-08-01
The possibility of using tapered or parabolic capillaries for measurement of liquid viscosities is investigated both experimentally and theoretically. It is demonstrated that even small deviations in capillary radius from a constant value may substantially affect measurement results. Equations are derived which allow correct analysis of the measurement results in tapered or parabolic capillaries. The following cases are analyzed: a water imbibition into a tapered or parabolic capillary and displacement of one liquid by another immiscible liquid in tapered or parabolic capillaries. Two possibilities are considered: (a) the narrow end of the capillary as capillary inlet and (b) the wide end of the capillary as capillary inlet. Copyright 1999 Academic Press.
Thermal analysis of a compound parabolic concentrator for refrigeration applications
Ortega, Naghelli; Best, Roberto [Centro de Investigacion en Energia, UNAM, Temixco, Morelos (Mexico)
2000-07-01
The refrigeration system designed at the Centro de Investigacion en Energia (CIE), Mexico is able to produce, in optimal conditions, one hundred kilograms per day of ice by means of solar energy. A continuous absorption ammonia-water refrigeration cycle is employed. In its actual state, heat supply to the system is provided through a bank of evacuated tube solar collectors. Their principal difficulties encountered in this system are the indirect heat losses due to the coupling of the falling film generator to the solar heating subsystem that requires a heat transfer gradient and higher collector operating temperatures. Also the high initial cost of the evacuated tube collectors is a barrier for an economical feasible system. Currently, new types of solar collectors are being considered, more efficient and reliable, with a potentially lower cost. This type of collectors known as Compound Parabolic Collectors (CPC) succeed in working at the required temperatures for absorption refrigeration systems. Therefore, a new system is suggested and it is proposed to use a CPC array, where heat losses by the indirect heating system are avoided. In this work a simple method was developed in order to establish the energy balances in a CPC, with a steel tubular receiver without an evacuated glass shell. The receptor's model considers a bidimensional system in stationary state and it supposes a continuous medium. Four nonlinear, simultaneous equations were obtained to predict heat exchange among various components in the system. These equations were utilized in a computer program to analyze the collector performance under various operating conditions. Consequently, the prediction of temperature distribution with respect to position permits to calculate length and arrangement of the CPC for a determined refrigeration application. [Spanish] El sistema de refrigeracion en el Centro de Investigacion en Energia (CIE) Mexico es capaz de producir en condiciones optimas 100
Comparison of resonant tunneling in AlGaAs/GaAs parabolic and diffusion modiﬁed quantum wells
Sudhira Panda; B K Panda; S Fung
2003-07-01
Double barrier resonant tunneling diode using annealing induced diffusion modiﬁed quantum well is proposed as a viable alternative to that using parabolic quantum well which requires complex techniques to fabricate it. The transmission coefﬁcients are calculated using the hybrid incremental airy function plane wave approach. The room temperature current–voltage characteristics have been calculated using transmission coefﬁcients. The current–voltage characteristics are found to be similar in both diodes.
Assessment of an in vitro model of pulmonary barrier to study the translocation of nanoparticles
Samir Dekali
2014-01-01
The use of Calu-3 cells allowed high transepithelial electrical resistance (TEER values (>1000 Ω cm2 in co-cultures with or without macrophages. After 24 h of exposure to non-cytotoxic concentrations of non-functionalized PS nanobeads, the relative TEER values (%/t0 were significantly decreased in co-cultures. Epithelial cells and macrophages were able to internalize PS nanobeads. Regarding translocation, Transwell® membranes per se limit the passage of nanoparticles between apical and basal side. However, small non-functionalized PS nanobeads (51 nm were able to translocate as they were detected in the basal side of co-cultures. Altogether, these results show that this co-culture model present good barrier properties allowing the study of nanoparticle translocation but research effort need to be done to improve the neutrality of the porous membrane delimitating apical and basal sides of the model.
Carman, R.J. [Department of Physics, Division of Information and Communications Sciences, Macquarie University, Sydney, NSW (Australia)). E-mail: rcarman@physics.mq.edu.au; Mildren, R.P. [Centre for Lasers and Applications, Division of Information and Communications Sciences, Macquarie University, Sydney, NSW (Australia)
2000-10-07
In modelling the plasma kinetics in dielectric barrier discharges (DBDs), the electron energy conservation equation is often included in the rate equation analysis (rather than utilizing the local-field approximation) with the assumption that the electron energy distribution function (EEDF) has a Maxwellian profile. We show that adopting a Maxwellian EEDF leads to a serious overestimate of the calculated ionization/excitation rate coefficients and the electron mobility for typical plasma conditions in a xenon DBD. Alternative EEDF profiles are trialed (Druyvesteyn, bi-Maxwellian and bi-Druyvesteyn) and benchmarked against EEDFs obtained from solving the steady-state Boltzmann equation. A bi-Druyvesteyn EEDF is shown to be more inherently accurate for modelling simulations of xenon DBDs. (author)
Optimal Wentzell Boundary Control of Parabolic Equations
Luo, Yousong, E-mail: yousong.luo@rmit.edu.au [RMIT University, School of Mathematical and Geospatial Sciences (Australia)
2017-04-15
This paper deals with a class of optimal control problems governed by an initial-boundary value problem of a parabolic equation. The case of semi-linear boundary control is studied where the control is applied to the system via the Wentzell boundary condition. The differentiability of the state variable with respect to the control is established and hence a necessary condition is derived for the optimal solution in the case of both unconstrained and constrained problems. The condition is also sufficient for the unconstrained convex problems. A second order condition is also derived.
Linear Parabolic Maps on the Torus
Zyczkowski, K; Zyczkowski, Karol; Nishikawa, Takashi
1999-01-01
We investigate linear parabolic maps on the torus. In a generic case these maps are non-invertible and discontinuous. Although the metric entropy of these systems is equal to zero, their dynamics is non-trivial due to folding of the image of the unit square into the torus. We study the structure of the maximal invariant set, and in a generic case we prove the sensitive dependence on the initial conditions. We study the decay of correlations and the diffusion in the corresponding system on the plane. We also demonstrate how the rationality of the real numbers defining the map influences the dynamical properties of the system.
Surface roughness estimation of a parabolic reflector
Casco, Nicolás A
2010-01-01
Random surface deviations in a reflector antenna reduce the aperture efficiency. This communication presents a method for estimating the mean surface deviation of a parabolic reflector from a set of measured points. The proposed method takes into account systematic measurement errors, such as the offset between the origin of reference frame and the vertex of the surface, and the misalignment between the surface rotation axis and the measurement axis. The results will be applied to perform corrections to the surface of one of the 30 m diameter radiotelescopes at the Instituto Argentino de Radioastronom\\'ia (IAR).
Alignment method for parabolic trough solar concentrators
Diver, Richard B [Albuquerque, NM
2010-02-23
A Theoretical Overlay Photographic (TOP) alignment method uses the overlay of a theoretical projected image of a perfectly aligned concentrator on a photographic image of the concentrator to align the mirror facets of a parabolic trough solar concentrator. The alignment method is practical and straightforward, and inherently aligns the mirror facets to the receiver. When integrated with clinometer measurements for which gravity and mechanical drag effects have been accounted for and which are made in a manner and location consistent with the alignment method, all of the mirrors on a common drive can be aligned and optimized for any concentrator orientation.
Gonzva, Michael; Barroca, Bruno
2017-04-01
The vulnerability of guided transport systems facing natural hazards is a burning issue for the urban risks management. Experience feedbacks on guided transport systems show they are particularly vulnerable to natural risks, especially flood risks. Besides, the resilience concept is used as a systemic approach for making an accurate analysis of the effect of these natural risks on rail guided transport systems. In this context, several conceptual models of resilience are elaborated for presenting the various possible resilience strategies applied to urban technical systems. One of this resilience conceptual model is the so-called "Behind The Barriers" model based on the identification of four complementary types of resilience: (i) cognitive resilience, linked to knowledge of the risk and the potential failures; (ii) functional resilience, representing the capacity of a system to protect itself from damage while continuing to provide services; (iii) correlative resilience, that characterises the relationship between service demand and the capacity of the system to respond; (iv) organisational resilience, expressing the capacity to mobilise an area much wider than the one affected. In addition to the work already published during the 7th Resilience Engineering Symposium, the purpose of this paper is to offer an application of a resilience conceptual model, the "Behind the Barriers" model, relating to a specific urban technical system, the public guided transport system, and facing a particular risk, a flood hazard. To do that, the paper is focused on a past incident on a French Intercity railway line as a studied case. Indeed, on June 18th and 19th 2013, the rise of the level of the "Gave de Pau" river, located in the municipality of Coarraze, caused many disorders on the intercity line serving the cities of Tarbes, Pau and Lourdes . Among the disorders caused by the flooding, about 100 meters of railway embankments were collapsed. With a constraint to reopen the
Modeling barriers of solid waste to energy practices: An Indian perspective
S. Bag
2016-01-01
Full Text Available In recent years managing solid wastes has been one of the burning problems in front of state and local municipal authorities. This is mainly due to scarcity of lands for landfill sites. In this context experts suggest that conversion of solid waste to energy and useful component is the best approach to reduce space and public health related problems. The entire process has to be managed by technologies that prevent pollution and protect the environment and at the same time minimize the cost through recovery of energy. Energy recovery in the form of electricity, heat and fuel from the waste using different technologies is possible through a variety of processes, including incineration, gasification, pyrolysis and anaerobic digestion. These processes are often grouped under “Waste to Energy technologies”. The objective of the study is twofold. First authors assessed the current status of solid waste management practices in India. Secondly the leading barriers are identified and Interpretive structural modeling technique and MICMAC analysis is performed to identify the contextual interrelationships between leading barriers influencing the solid waste to energy programs in the country. Finally the conclusions are drawn which will assist policy makers in designing sustainable waste management programs.
Modelling of the humidity effect on the barrier height in SnO{sub 2} varistors
Skuratovsky, I. [Department of Radioelectronics, Dniepropetrovsk National University, Dniepropetrovsk 49050 (Ukraine); Glot, A. [Division de Estudios de Posgrado, Universidad Tecnologica de la Mixteca, Huajuapan de Leon, Oaxaca 69000 (Mexico)]. E-mail: alexglot@mixteco.utm.mx; Traversa, E. [Dip. di Scienze e Tecnologie Chimiche, Universita di Roma ' Tor Vergata' , Via della Ricerca Scientifica, 00133 Rome (Italy)
2006-03-15
Tin dioxide based SnO{sub 2}-Bi{sub 2}O{sub 3}-Co{sub 3}O{sub 4}-Nb{sub 2}O{sub 5}-Cr{sub 2}O{sub 3} ceramic device with combined varistor and humidity-sensitive properties is studied. This varistor-sensor has high humidity sensitivity coefficient of about 420 at low electric field and high non-linearity coefficient of about 50 at electric field 3500 V cm{sup -1}. Current-voltage characteristics of the samples with separate electrodes for the central and the peripheral parts are studied in air with different relative humidity. It is shown that current through the peripheral part of a sample is increased much stronger than through the central part. The observed increase of low-field current on relative humidity is explained by the decrease of the barrier height. The estimations of the lowering of the barrier height in a humid air is performed using the suggested models.
Booth, R; Kim, H
2014-12-01
This paper presents the permeability analysis of neuroactive drugs and correlation with in vivo brain/plasma ratios in a dynamic microfluidic blood-brain barrier (BBB) model. Permeability of seven neuroactive drugs (Ethosuximide, Gabapentin, Sertraline, Sunitinib, Traxoprodil, Varenicline, PF-304014) and trans-endothelial electrical resistance (TEER) were quantified in both dynamic (microfluidic) and static (transwell) BBB models, either with brain endothelial cells (bEnd.3) in monoculture, or in co-culture with glial cells (C6). Dynamic cultures were exposed to 15 dyn/cm(2) shear stress to mimic the in vivo environment. Dynamic models resulted in significantly higher average TEER (respective 5.9-fold and 8.9-fold increase for co-culture and monoculture models) and lower drug permeabilities (average respective decrease of 0.050 and 0.052 log(cm/s) for co-culture and monoculture) than static models; and co-culture models demonstrated higher average TEER (respective 90 and 25% increase for static and dynamic models) and lower drug permeability (average respective decrease of 0.063 and 0.061 log(cm/s) for static and dynamic models) than monoculture models. Correlation of the resultant logP e values [ranging from -4.06 to -3.63 log(cm/s)] with in vivo brain/plasma ratios (ranging from 0.42 to 26.8) showed highly linear correlation (R (2) > 0.85) for all model conditions, indicating the feasibility of the dynamic microfluidic BBB model for prediction of BBB clearance of pharmaceuticals.
Environmental Barrier Coating (EBC) Durability Modeling; An Overview and Preliminary Analysis
Abdul-Aziz, A.; Bhatt, R. T.; Grady, J. E.; Zhu, D.
2012-01-01
A study outlining a fracture mechanics based model that is being developed to investigate crack growth and spallation of environmental barrier coating (EBC) under thermal cycling conditions is presented. A description of the current plan and a model to estimate thermal residual stresses in the coating and preliminary fracture mechanics concepts for studying crack growth in the coating are also discussed. A road map for modeling life and durability of the EBC and the results of FEA model(s) developed for predicting thermal residual stresses and the cracking behavior of the coating are generated and described. Further initial assessment and preliminary results showed that developing a comprehensive EBC life prediction model incorporating EBC cracking, degradation and spalling mechanism under stress and temperature gradients typically seen in turbine components is difficult. This is basically due to mismatch in thermal expansion difference between sub-layers of EBC as well as between EBC and substrate, diffusion of moisture and oxygen though the coating, and densification of the coating during operating conditions as well as due to foreign object damage, the EBC can also crack and spall from the substrate causing oxidation and recession and reducing the design life of the EBC coated substrate.
Honda, Mitsuru
2005-10-01
In order to predict the performance of ITER plasma, it is important to validate the existing theory-based turbulent transport models by systematicallycomparing them with the experimental observations. Taking experimental data from the ITPA profile database, we have carried out transport simulations with the CDBM, GLF23 and Weiland models by the one-dimensional diffusive transport code TASK/TR. The results are evaluated by the six figures of merit as specified in ITER Physics Basis^1. From the simulation on 55 discharges, it is found that each model has unique dependence on devices and operation modes and the CDBM model gives the most satisfactory results. We have incorporated the dependence on the elongation on the CDBM model^2 and confirmed that the accuracy of the prediction is improved for H-mode discharges. Single-particle-species heat transport simulations have indicated that the CDBM model reproduces Ti profiles more accurately than Te profiles. We will also show the results of the predictive simulations coupling TASK/TR and TASK/EQ, two-dimensional equilibrium code, for high performance plasmas with internal transport barriers like the high βp and reversed shear plasmas. [1] ITER Physics Basis Expert Groups, Nucl. Fusion, 39, 2175 (1999) [2] M. Yagi et al., J. Phys. Soc. Japan, 66, 379 (1997)
Collagen Micro-Flow Channels as an for In vitro Blood-Brain Barrier Model
Shibata, Katsuya; Terazono, Hideyuki; Hattori, Akihiro; Yasuda, Kenji
2008-06-01
An in vitro blood-brain barrier (BBB) model is useful for drug discovery and efficacy measurements because it is a simple and convenient model of the in vivo BBB. However, the conventional in vitro BBB model does not account for shear stress to endotherial cell (EC) layers although in vivo ECs are exposed by shear stress. To improve this deficiency, we applied a microfluidics technique to a conventional in vitro BBB model and constructed a new in vitro BBB model. First, we confirmed that ECs can survive and proliferate on a cross-linked collagen gel and on an agarose including microbeads decorated with collagen type IV (CIV). In addition, we found that the cross-linker 1-ethyl-3carbodiimide hydrochloride (EDC) with N-hydroxysuccinimide (NHS) is less effective for EC proliferation than glutaraldehyde (GA), ethyleneglycol diglycidyl ether (EGDE), and agarose with microbeads. Applying a focused infrared laser, we fabricated microtunnels within the collagen gel, and we successfully cultured ECs on the inner tunnel wall. The results indicate the potential of gel microstructures for a microfluidic in vitro BBB model.
Predictive model of blood-brain barrier penetration of organic compounds
Xiao-lei MA; Cheng CHEN; Jie YANG
2005-01-01
Aim: To build up a theoretical model of organic compounds for the prediction of the activity of small molecules through the blood-brain barrier (BBB) in drug design. Methods: A training set of 37 structurally diverse compounds was used to construct quantitative structure-activity relationship (QSAR) models. Intermolecular and intramolecular solute descriptors were calculated using molecular mechanics, molecular dynamics simulations, quantum chemistry and so on. The QSAR models were optimized using multidimensional linear regression fitting and stepwise method. A test set of 8 compounds was evaluated using the models as part of a validation process. Results: Significant QSAR models (R=0.955, s=0.232) of the BBB penetration of organic compounds were constructed. BBB penetrationwas found to depend upon the polar surface area, the octanol/water partition coefficient, Balaban Index, the strength of a small molecule to combine with the membrane-water complex, and the changeability of the structure of a solute-membrane-water complex. Conclusion: The QSAR models indicate that the distribution of organic molecules through BBB is not only influenced by organic solutes themselves, but also relates to the properties of the solute-membrane-water complex, that is, interactions of the molecule with the phospholipid-rich regions of cellular membranes.
Pin, D; Bekrich, M; Fantini, O; Noel, G; Vidémont, E
2014-01-01
The aim of this study was to investigate the effect of Douxo(®) Calm Mousse (Sogeval, Laval, France) on restoration of the skin barrier in a canine model of barrier disruption. Tape strips were performed, daily for 6 days, on the lateral thorax of five healthy beagle dogs. Douxo(®) Calm Mousse was applied daily for 5 days to one side of the thorax and the opposite side was left untreated. The effects of treatment were evaluated by measurement of transepidermal water loss (TEWL) and pH and by histological assessment of disrupted skin at various times during barrier repair. Although no effect on TEWL was observed, Douxo(®) Calm Mousse maintained an acidic pH after three applications and reduced skin inflammation, which was most pronounced after five applications. The results of the study suggest that Douxo(®) Calm Mousse exerts a beneficial effect on barrier restoration and on markers of inflammation.
Barriers of access to care in a managed competition model: lessons from Colombia
Mogollón-Pérez Amparo Susana
2010-10-01
Full Text Available Abstract Background The health sector reform in Colombia, initiated by Law 100 (1993 that introduced a managed competition model, is generally presented as a successful experience of improving access to care through a health insurance regulated market. The study's objective is to improve our understanding of the factors influencing access to the continuum of care in the Colombian managed competition model, from the social actors' point of view. Methods An exploratory, descriptive-interpretative qualitative study was carried out, based on case studies of four healthcare networks in rural and urban areas. Individual semi-structured interviews were conducted to a three stage theoretical sample: I cases, II providers and III informants: insured and uninsured users (35, health professionals (51, administrative personnel (20, and providers' (18 and insurers' (10 managers. Narrative content analysis was conducted; segmented by cases, informant's groups and themes. Results Access, particularly to secondary care, is perceived as complex due to four groups of obstacles with synergetic effects: segmented insurance design with insufficient services covered; insurers' managed care and purchasing mechanisms; providers' networks structural and organizational limitations; and, poor living conditions. Insurers' and providers' values based on economic profit permeate all factors. Variations became apparent between the two geographical areas and insurance schemes. In the urban areas barriers related to market functioning predominate, whereas in the rural areas structural deficiencies in health services are linked to insufficient public funding. While financial obstacles are dominant in the subsidized regime, in the contributory scheme supply shortage prevails, related to insufficient private investment. Conclusions The results show how in the Colombian healthcare system structural and organizational barriers to care access, that are common in developing countries
Yan, Na; Baas, Andreas
2015-04-01
Parabolic dunes are one of a few common aeolian landforms which are highly controlled by eco-geomorphic interactions. Parabolic dunes, on the one hand, can be developed from highly mobile dune landforms, barchans for instance, in an ameliorated vegetation condition; or on the other hand, they can be reactivated and transformed back into mobile dunes due to vegetation deterioration. The fundamental mechanisms and eco-geomorphic interactions controlling both dune transformations remain poorly understood. To bridge the gap between complex processes involved in dune transformations on a relatively long temporal scale and real world monitoring records on a very limited temporal scale, this research has extended the DECAL model to incorporate 'dynamic' growth functions and the different 'growth' of perennial shrubs between growing and non-growing seasons, informed by field measurements and remote sensing analysis, to explore environmental controls and eco-geomorphic interactions of both types of dune transformation. A non-dimensional 'dune stabilising index' is proposed to capture the interactions between environmental controls (i.e. the capabilities of vegetation to withstand wind erosion and sand burial, the sandy substratum thickness, the height of the initial dune, and the sand transport potential), and establish the linkage between these controls and the geometry of a stabilising dune. An example demonstrates how to use the power-law relationship between the dune stabilising index and the normalised migration distance to assist in extrapolating the historical trajectories of transforming dunes. The modelling results also show that a slight increase in vegetation cover of an initial parabolic dune can significantly increase the reactivation threshold of climatic impact (both drought stress and wind strength) required to reactivate a stabilising parabolic dune into a barchan. Four eco-geomorphic interaction zones that govern a barchan-to-parabolic dune transformation
Nishiguchi, Akihiro; Singh, Smriti; Wessling, Matthias; Kirkpatrick, Charles J; Möller, Martin
2017-03-13
In vitro reconstruction of an alveolar barrier for modeling normal lung functions and pathological events serve as reproducible, high-throughput pharmaceutical platforms for drug discovery, diagnosis, and regenerative medicine. Despite much effort, the reconstruction of organ-level alveolar barrier functions has failed due to the lack of structural similarity to the natural basement membrane, functionalization with specific ligands for alveolar cell function, the use of primary cells and biodegradability. Here we report a bipolar cultured alveolar-capillary barrier model of human primary cells supported by a basement membrane mimics of fully synthetic bifunctional nanofibers. One-step electrospinning process using a bioresorbable polyester and multifunctional star-shaped polyethylene glycols (sPEG) enables the fabrication of an ultrathin nanofiber mesh with interconnected pores. The nanofiber mesh possessed mechanical stability against cyclic expansion as seen in the lung in vivo. The sPEGs as an additive provide biofunctionality to fibers through the conjugation of peptide to the nanofibers and hydrophilization to prevent unspecific protein adsorption. Biofunctionalized nanofiber meshes facilitated bipolar cultivation of endothelial and epithelial cells with fundamental alveolar functionality and showed higher permeability for molecules compared to microporous films. This nanofiber mesh for a bipolar cultured barrier have the potential to promote growth of an organ-level barrier model for modeling pathological conditions and evaluating drug efficacy, environmental pollutants, and nanotoxicology.
Gordon, S.; Daneshian, M.; Bouwstra, J.A.; Caloni, F.; Constant, S.; Davies, D.E.; Dandekar, G.; Guzman, C.A.; Fabian, E.; Haltner, E.; Hartung, T.; Hasiwa, N.; Hayden, P.; Kandarova, H.; Khare, S.; Krug, H.F.; Kneuer, C.; Leist, M.; Lian, G.; Marx, U.; Metzger, M.; Ott, K.; Prieto, P.; Roberts, M.S.; Roggen, E.L.; Tralau, T.; Braak, van den C.; Walles, H.; Lehr, C.M.
2015-01-01
Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields,
Gordon, S.; Daneshian, M.; Bouwstra, J.A.; Caloni, F.; Constant, S.; Davies, D.E.; Dandekar, G.; Guzman, C.A.; Fabian, E.; Haltner, E.; Hartung, T.; Hasiwa, N.; Hayden, P.; Kandarova, H.; Khare, S.; Krug, H.F.; Kneuer, C.; Leist, M.; Lian, G.; Marx, U.; Metzger, M.; Ott, K.; Prieto, P.; Roberts, M.S.; Roggen, E.L.; Tralau, T.; Braak, van den C.; Walles, H.; Lehr, C.M.
2015-01-01
Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields,
Representation of the Antarctic circumpolar vortex mixing barrier in a Global Climate Model
Cameron, Chris; Conway, Jono; Bodeker, Greg; Renwick, James
2017-04-01
Dynamical processes that occur in the stratosphere between 15 and 50 km above Earth's surface can affect circulation in the troposphere and have an impact on weather and climate. The Antarctic Circumpolar Vortex (ACV) forms each winter and spring as a zone of strong stratospheric westerly winds surrounding Antarctica. The ACV presents a barrier to transport of air masses between middle and high-latitudes, and contributes to stratospheric temperatures above the polar region dropping sufficiently low in spring to allow for ozone loss. The processes controlling the permeability of the ACV, and how they are likely to respond to a changing climate and a recovering ozone hole, have not been well studied, and as a result are not well simulated in Global Climate Models, particularly in terms of sub-grid scale turbulent diffusion which is parameterized in the models. The UK Met Office Unified Model (UM) is used to examine vortex permeability using both the "New Dynamics" and the upgraded "ENDGame" dynamical cores. Results are compared against reanalysis representations of vortex permeability using the MERRA-2 and ERA-Interim reanalyses data sets, which have been shown to have superior performance in the Southern Hemisphere stratosphere when compared against NCEP-CFSR, and MERRA reanalyses. Results are expected to lead to improved representation of ACV transport process in Global Climate Models and subsequent improvements in climate modelling.
A Concentrator Photovoltaic System Based on a Combination of Prism-Compound Parabolic Concentrators
Ngoc Hai Vu
2016-08-01
Full Text Available We present a cost-effective concentrating photovoltaic system composed of a prism and a compound parabolic concentrator (P-CPC. In this approach, the primary collector consists of a prism, a solid compound parabolic concentrator (CPC, and a slab waveguide. The prism, which is placed on the input aperture of CPC, directs the incoming sunlight beam to be parallel with the main axes of parabolic rims of CPC. Then, the sunlight is reflected at the parabolic rims and concentrated at the focal point of these parabolas. A slab waveguide is coupled at the output aperture of the CPC to collect focused sunlight beams and to guide them to the solar cell. The optical system was modeled and simulated with commercial ray tracing software (LightTools™. Simulation results show that the optical efficiency of a P-CPC can achieve up to 89%. when the concentration ratio of the P-CPC is fixed at 50. We also determine an optimal geometric structure of P-CPC based on simulation. Because of the simplicity of the P-CPC structure, a lower-cost mass production process is possible. A simulation based on optimal structure of P-CPC was performed and the results also shown that P-CPC has high angular tolerance for input sunlight. The high tolerance of the input angle of sunlight allows P-CPC solar concentrator utilize a single sun tracking system instead of a highly precise dual suntracking system as cost effective solution.
L Haibin; XIE Jieshuo; YAO Yuan; XU Jiexin; CHEN Zhiwu; HE Yinghui; CAI Shuqun
2016-01-01
Based on modifications of the observed background parabolic current in upper layer of the northeastern South China Sea (SCS), the effects of eight kinds of background currents on the characteristics and energy conversion of internal solitary waves (ISWs) are investigated by an Internal Gravity Wave (IGW) model. It is found that, although the background current has little effect on the number of the generated ISWs, it reduces the resulted phase speed of ISW. When the background parabolic current appears with its lower boundary near or above the main thermocline, the ISW amplitude and the depth of the isopycnal undergoing maximum displacement increase;when the background parabolic current curvature is reduced, the ISW amplitude and the ratio of baroclinic to barotropic energy reduce, whilst the phase speed of ISW, the baroclinic energy, and the ratio of baroclinic kinetic energy (KE) to available potential energy (APE) increase; when the lower boundary of background parabolic current extends down to the seabed and the background current curvature is reduced, the ISW amplitude and phase speed decrease, whilst the barotropic kinetic energy, the baroclinic energy and the ratio of KE to APE increase. At a whole depth, when the lower background current curvature is reduced and the upper current curvature is increased, the ISW amplitude, and phase speed, the ratio of baroclinic to barotropic energy, the baroclinic energy, and the ratio of KE to APE all increase.
Effects of the non-parabolic kinetic energy on non-equilibrium polariton condensates.
Pinsker, F; Ruan, X; Alexander, T J
2017-05-15
In the study of non-equilibrium polariton condensates it is usually assumed that the dispersion relation of polaritons is parabolic in nature. We show that considering the true non-parabolic kinetic energy of polaritons leads to significant changes in the behaviour of the condensate due to the curvature of the dispersion relation and the possibility of transfer of energy to high wavenumber components in the condensate spatial profile. We present explicit solutions for plane waves and linear excitations, and identify the differences in the theoretical predictions between the parabolic and non-parabolic mean-field models, showing the possibility of symmetry breaking in the latter. We then consider the evolution of wavepackets and show that self-localisation effects may be observed due to the curvature of the dispersion relation. Finally, we revisit the dynamics of dark soliton trains and show that additional localized density excitations may emerge in the dynamics due to the excitation of high frequency components, mimicking the appearance of near-bright solitary waves over short timescales.
SURFACE FINITE ELEMENTS FOR PARABOLIC EQUATIONS
G. Dziuk; C.M. Elliott
2007-01-01
In this article we define a surface finite element method (SFEM) for the numerical solution of parabolic partial differential equations on hypersurfaces Γ in (R)n+1. The key idea is based on the approximation of Γ by a polyhedral surface Γh consisting of a union of simplices (triangles for n = 2, intervals for n = 1) with vertices on Γ. A finite element space of functions is then defined by taking the continuous functions on Γh which are linear affine on each simplex of the polygonal surface. We use surface gradients to define weak forms of elliptic operators and naturally generate weak formulations of elliptic and parabolic equations on Γ. Our finite element method is applied to weak forms of the equations. The computation of the mass and element stiffness matrices are simple and straightforward.We give an example of error bounds in the case of semi-discretization in space for a fourth order linear problem. Numerical experiments are described for several linear and nonlinear partial differential equations. In particular the power of the method is demonstrated by employing it to solve highly nonlinear second and fourth order problems such as surface Allen-Cahn and Cahn-Hilliard equations and surface level set equations for geodesic mean curvature flow.
Focusing parabolic guide for very small samples
Hils, T.; Boeni, P.; Stahn, J
2004-07-15
Modern materials can often only be grown in small quantities. Therefore, neutron-scattering experiments are difficult to perform due to the low signal. In order to increase the flux at the sample position, we have developed the concept of a small focusing guide tube with parabolically shaped walls that are coated with supermirror m=3. The major advantage of parabolic focusing is that the flux maximum occurs not at the exit of the tube. It occurs at the focal point that can be several centimeters away from the exit of the tube. We show that an intensity gain of 6 can easily be obtained. Simulations using the software package McStas demonstrate that gain factors up to more than 50 can be realised on a spot size of approximately 1.2 mm diameter. For PGAA we expect flux gains of up to three orders of magnitude if multiplexing is used. We show that elliptic ballistic guides lead to flux gains of more than 6.
Focusing parabolic guide for very small samples
Hils, T.; Boeni, P.; Stahn, J.
2004-07-01
Modern materials can often only be grown in small quantities. Therefore, neutron-scattering experiments are difficult to perform due to the low signal. In order to increase the flux at the sample position, we have developed the concept of a small focusing guide tube with parabolically shaped walls that are coated with supermirror m=3. The major advantage of parabolic focusing is that the flux maximum occurs not at the exit of the tube. It occurs at the focal point that can be several centimeters away from the exit of the tube. We show that an intensity gain of 6 can easily be obtained. Simulations using the software package McStas demonstrate that gain factors up to more than 50 can be realised on a spot size of approximately 1.2 mm diameter. For PGAA we expect flux gains of up to three orders of magnitude if multiplexing is used. We show that elliptic ballistic guides lead to flux gains of more than 6.
A nonlocal parabolic system with application to a thermoelastic problem
Y. Lin
1999-01-01
problem is first transformed into an equivalent nonlocal parabolic systems using a transformation, and then the existence and uniqueness of the solutions are demonstrated via the theoretical potential representation theory of the parabolic equations. Finally some realistic situations in the applications are discussed using the results obtained in this paper.
Almost Periodic Viscosity Solutions of Nonlinear Parabolic Equations
Zhang Shilin
2009-01-01
Full Text Available We generalize the comparison result 2007 on Hamilton-Jacobi equations to nonlinear parabolic equations, then by using Perron's method to study the existence and uniqueness of time almost periodic viscosity solutions of nonlinear parabolic equations under usual hypotheses.
Carleman Estimates for Parabolic Equations with Nonhomogeneous Boundary Conditions
Oleg Yu IMANUVILOV; Jean Pierre PUEL; Masahiro YAMAMOTO
2009-01-01
The authors prove a new Carleman estimate for general linear second order parabolic equation with nonhomogeneous boundary conditions.On the basis of this estimate,improved Carleman estimates for the Stokes system and for a system of parabolic equations with a penalty term are obtained.This system can be viewed as an approximation of the Stokes system.
Flux form Semi-Lagrangian methods for parabolic problems
Bonaventura, Luca
2015-01-01
A semi-Lagrangian method for parabolic problems is proposed, that extends previous work by the authors to achieve a fully conservative, flux-form discretization of linear and nonlinear diffusion equations. A basic consistency and convergence analysis are proposed. Numerical examples validate the proposed method and display its potential for consistent semi-Lagrangian discretization of advection--diffusion and nonlinear parabolic problems.
A numerical study of mixed parabolic-gradient systems
Verwer, J.G.; Sommeijer, B.P.
2000-01-01
This paper is concerned with the numerical solution of parabolic equations coupled to gradient equations. The gradient equations are ordinary differential equations whose solutions define positions of particles in the spatial domain of the parabolic equations. The vector field of the gradient equati
The parabolic equation method for outdoor sound propagation
Arranz, Marta Galindo
The parabolic equation method is a versatile tool for outdoor sound propagation. The present study has focused on the Cranck-Nicolson type Parabolic Equation method (CNPE). Three different applications of the CNPE method have been investigated. The first two applications study variations...
STABILITY OF A PARABOLIC FIXED POINT OF REVERSIBLE MAPPINGS
LIUBIN; YOUJIANGONG
1994-01-01
KAM theorem of reversible system is used to provide a sufficient condition which guarantees the stability of a parabolic fixed point of reversible mappings, The main idea is to discuss when the parabolic fixed point is surrounded by closed invariant carves and thus exhibits stable behaviour.
Manipulation of dielectric particles with nondiffracting parabolic beams.
Ortiz-Ambriz, Antonio; Gutiérrez-Vega, Julio C; Petrov, Dmitri
2014-12-01
The trapping and manipulation of microscopic particles embedded in the structure of nondiffracting parabolic beams is reported. The particles acquire orbital angular momentum and exhibit an open trajectory following the parabolic fringes of the beam. We observe an asymmetry in the terminal velocity of the particles caused by the counteracting gradient and scattering forces.
Surface plasmon polariton beam focusing with parabolic nanoparticle chains
Radko, Ilya P.; Bozhevolnyi, Sergey I.; Evlyukhin, Andrey B.
2007-01-01
We report on the focusing of surface plasmon polariton (SPP) beams with parabolic chains of gold nanoparticles fabricated on thin gold films. SPP focusing with different parabolic chains is investigated in the wavelength range of 700–860 nm, both experimentally and theoretically. Mapping of SPP...
Shock Analysis of Sentinel-3 SLSTR Parabolic Mirror Assembly
Braun, Benjamin; Kiel, Daniel
2014-06-01
This paper presents the different steps that have been undertaken to demonstrate the successful shock qualification of the Parabolic Mirror Assembly (PMA) in the frame of the Sentinel-3 SLSTR development. The unit has failed the first qualification shock test in terms of shift of natural frequencies and optical alignment. The objectives of the subsequent analyses are:- to correlate the finite element model with the PMA shock test on unit level,- to determine the interface loads between different parts of the PMA assembly for the PMA shock test on unit level,- to assess the PMA interface loads induced by the instrument level shock test,- to derive a reduced shock input spectrum for the PMA shock test on unit level with respect to a second qualification test.
Identifying Initial Condition in Degenerate Parabolic Equation with Singular Potential
K. Atifi
2017-01-01
Full Text Available A hybrid algorithm and regularization method are proposed, for the first time, to solve the one-dimensional degenerate inverse heat conduction problem to estimate the initial temperature distribution from point measurements. The evolution of the heat is given by a degenerate parabolic equation with singular potential. This problem can be formulated in a least-squares framework, an iterative procedure which minimizes the difference between the given measurements and the value at sensor locations of a reconstructed field. The mathematical model leads to a nonconvex minimization problem. To solve it, we prove the existence of at least one solution of problem and we propose two approaches: the first is based on a Tikhonov regularization, while the second approach is based on a hybrid genetic algorithm (married genetic with descent method type gradient. Some numerical experiments are given.
Adaptive distributed parameter and input estimation in linear parabolic PDEs
Mechhoud, Sarra
2016-01-01
In this paper, we discuss the on-line estimation of distributed source term, diffusion, and reaction coefficients of a linear parabolic partial differential equation using both distributed and interior-point measurements. First, new sufficient identifiability conditions of the input and the parameter simultaneous estimation are stated. Then, by means of Lyapunov-based design, an adaptive estimator is derived in the infinite-dimensional framework. It consists of a state observer and gradient-based parameter and input adaptation laws. The parameter convergence depends on the plant signal richness assumption, whereas the state convergence is established using a Lyapunov approach. The results of the paper are illustrated by simulation on tokamak plasma heat transport model using simulated data.
Strong Superconvergence of Finite Element Methods for Linear Parabolic Problems
Kening Wang
2009-01-01
Full Text Available We study the strong superconvergence of a semidiscrete finite element scheme for linear parabolic problems on =Ω×(0,], where Ω is a bounded domain in ℛ(≤4 with piecewise smooth boundary. We establish the global two order superconvergence results for the error between the approximate solution and the Ritz projection of the exact solution of our model problem in 1,(Ω and ( with 2≤<∞ and the almost two order superconvergence in 1,∞(Ω and ∞(. Results of the =∞ case are also included in two space dimensions (=1 or 2. By applying the interpolated postprocessing technique, similar results are also obtained on the error between the interpolation of the approximate solution and the exact solution.
Statistical modelling of discharge behavior of atmospheric pressure dielectric barrier discharge
Tay, W. H.; Kausik, S. S.; Wong, C. S., E-mail: cswong@um.edu.my; Yap, S. L.; Muniandy, S. V. [Plasma Technology Research Centre, Department of Physics, Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia)
2014-11-15
In this work, stochastic behavior of atmospheric pressure dielectric barrier discharge (DBD) has been investigated. The experiment is performed in a DBD reactor consisting of a pair of stainless steel parallel plate electrodes powered by a 50 Hz ac high voltage source. Current pulse amplitude distributions for different space gaps and the time separation between consecutive current pulses are studied. A probability distribution function is proposed to predict the experimental distribution function for the current pulse amplitudes and the occurrence of the transition regime of the pulse distribution. Breakdown voltage at different positions on the dielectric surface is suggested to be stochastic in nature. The simulated results based on the proposed distribution function agreed well with the experimental results and able to predict the regime of transition voltage. This model would be useful for the understanding of stochastic behaviors of DBD and the design of DBD device for effective operation and applications.
Bicuculline methiodide in the blood-brain barrier-epileptogen model of epilepsy
Remler, M.P.; Marcussen, W.H.
Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviorally or on EEG at 36 mg/kg. When the BBB is opened in 0.25 ml of cortex by 6,000 rad of alpha particles, by a pin trauma lesion, or by a heat lesion, the rats are normal clinically and on EEG. When these lesioned rats are challenged with bicuculline methiodide, 36 mg/kg, an intense, highly localized epileptiform discharge results that begins approximately 20 min after injection and lasts 30-90 min. The plausibility and experimental utility of the BBB-epileptogen model of epilepsy are enhanced by these observations.
Anand, Prachi; O'Neil, Alison; Lin, Emily; Douglas, Trevor; Holford, Mandë
2015-08-01
The blood brain barrier (BBB) is often an insurmountable obstacle for a large number of candidate drugs, including peptides, antibiotics, and chemotherapeutic agents. Devising an adroit delivery method to cross the BBB is essential to unlocking widespread application of peptide therapeutics. Presented here is an engineered nanocontainer for delivering peptidic drugs across the BBB encapsulating the analgesic marine snail peptide ziconotide (Prialt®). We developed a bi-functional viral nanocontainer based on the Salmonella typhimurium bacteriophage P22 capsid, genetically incorporating ziconotide in the interior cavity, and chemically attaching cell penetrating HIV-Tat peptide on the exterior of the capsid. Virus like particles (VLPs) of P22 containing ziconotide were successfully transported in several BBB models of rat and human brain microvascular endothelial cells (BMVEC) using a recyclable noncytotoxic endocytic pathway. This work demonstrates proof in principle for developing a possible alternative to intrathecal injection of ziconotide using a tunable VLP drug delivery nanocontainer to cross the BBB.
Effect of nanoparticles and environmental particles on a cocultures model of the air-blood barrier.
Bengalli, Rossella; Mantecca, Paride; Camatini, Marina; Gualtieri, Maurizio
2013-01-01
Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effects of NPs and PM on human respiratory system and particularly on the air-blood barrier (ABB) has become of primary interest. The crosstalk between lung epithelial cells and underlying endothelial cells is indeed essential in determining the effects of inhaled particles. Here we report the effects of metal oxides NPs (CuO and TiO2) and of PM on an in vitro model of the ABB constituted by the type II epithelial cell line (NCI-H441) and the endothelial one (HPMEC-ST1.6R). The results demonstrate that apical exposure of alveolar cells induces significant modulation of proinflammatory proteins also in endothelial cells.
Finite Element Model Characterization Of Nano-Composite Thermal And Environmental Barrier Coatings
Yamada, Yoshiki; Zhu, Dongming
2011-01-01
Thermal and environmental barrier coatings have been applied for protecting Si based ceramic matrix composite components from high temperature environment in advanced gas turbine engines. It has been found that the delamination and lifetime of T/EBC systems generally depend on the initiation and propagation of surface cracks induced by the axial mechanical load in addition to severe thermal loads. In order to prevent T/EBC systems from surface cracking and subsequent delamination due to mechanical and thermal stresses, T/EBC systems reinforced with nano-composite architectures have showed promise to improve mechanical properties and provide a potential crack shielding mechanism such as crack bridging. In this study, a finite element model (FEM) was established to understand the potential beneficial effects of nano-composites systems such as SiC nanotube-reinforced oxide T/EBC systems.
Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier
Rossella Bengalli
2013-01-01
Full Text Available Exposure to engineered nanoparticles (NPs and to ambient particles (PM has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effects of NPs and PM on human respiratory system and particularly on the air-blood barrier (ABB has become of primary interest. The crosstalk between lung epithelial cells and underlying endothelial cells is indeed essential in determining the effects of inhaled particles. Here we report the effects of metal oxides NPs (CuO and TiO2 and of PM on an in vitro model of the ABB constituted by the type II epithelial cell line (NCI-H441 and the endothelial one (HPMEC-ST1.6R. The results demonstrate that apical exposure of alveolar cells induces significant modulation of proinflammatory proteins also in endothelial cells.
Ye, Dong; Anguissola, Sergio; O'Neill, Tiina; Dawson, Kenneth A.
2015-05-01
Subcellular location of nanoparticles has been widely investigated with fluorescence microscopy, via fluorescently labeled antibodies to visualise target antigens in cells. However, fluorescence microscopy, such as confocal or live cell imaging, has generally limited 3D spatial resolution. Conventional electron microscopy can be useful in bridging resolution gap, but still not ideal in resolving subcellular organelle identities. Using the pre-embedding immunogold electron microscopic imaging, we performed accurate examination of the intracellular trafficking and gathered further evidence of transport mechanisms of silica nanoparticles across a human in vitro blood-brain barrier model. Our approach can effectively immunolocalise a variety of intracellular compartments and provide new insights into the uptake and subcellular transport of nanoparticles.Subcellular location of nanoparticles has been widely investigated with fluorescence microscopy, via fluorescently labeled antibodies to visualise target antigens in cells. However, fluorescence microscopy, such as confocal or live cell imaging, has generally limited 3D spatial resolution. Conventional electron microscopy can be useful in bridging resolution gap, but still not ideal in resolving subcellular organelle identities. Using the pre-embedding immunogold electron microscopic imaging, we performed accurate examination of the intracellular trafficking and gathered further evidence of transport mechanisms of silica nanoparticles across a human in vitro blood-brain barrier model. Our approach can effectively immunolocalise a variety of intracellular compartments and provide new insights into the uptake and subcellular transport of nanoparticles. Electronic supplementary information (ESI) available: Nanoparticle characterisation data, preservation of cellular structures, staining controls, optimisation of size amplification via the silver enhancement, and more imaging results from anti-clathrin and anti-caveolin 1
Lin-Lin Qu; Ya-Qing Lyu; Hai-Tao Jiang; Ting Shan; Jing-Bin Zhang; Qiu-Rong Li; Jie-Shou Li
2015-01-01
Background:Alemtuzumab has been used in organ transplantation and a variety of hematologic malignancies (especially for the treatment of B-cell chronic lymphocytic leukemia).However,serious infectious complications frequently occur after treatment.The reason for increased infections postalemtuzumab treatment is unknown at this stage.We explore the effect ofalemtuzumab on intestinal intraepithelial lymphocytes (IELs) and intestinal barrier function in cynomolgus model to explain the reason of infection following alemtuzumab treatment.Methods:Twelve male cynomolguses were randomly assigned to either a treatment or control group.The treatment group received alemtuzumab (3 mg/kg,intravenous injection) while the control group received the same volume of physiological saline.Intestinal IELs were isolated from the control group and the treatment group (on day 9,35,and 70 after treatment) for counting and flow cytometric analysis.Moreover,intestinal permeability was monitored by enzymatic spectrophotometric technique and enzyme-linked immunosorbent assay.Results:The numbers of IELs were decreased significantly on day 9 after treatment compared with the control group (0.35 ± 0.07 x 108 and 1.35 ± 0.09 × 108,respectively; P ＜ 0.05) and were not fully restored until day 70 after treatment.There were significant differences among four groups considering IELs subtypes.In addition,the proportion ofapoptotic IELs after alemtuzumab treatment was significantly higher than in the control group (22.01 ± 3.67 and 6.01 ± 1.42,respectively; P ＜ 0.05).Moreover,the concentration of D-lactate and endotoxin was also increased significantly on day 9 after treatment.Conclusions:Alemtuzumab treatment depletes lymphocytes in the peripheral blood and intestine of cynomolgus model.The induction of apoptosis is an important mechanism of lymphocyte depletion after alemtuzumab treatment.Notably,intestinal barrier function may be disrupted after alemtuzumab treatment.
Lin-Lin Qu
2015-01-01
Full Text Available Background: Alemtuzumab has been used in organ transplantation and a variety of hematologic malignancies (especially for the treatment of B-cell chronic lymphocytic leukemia. However, serious infectious complications frequently occur after treatment. The reason for increased infections postalemtuzumab treatment is unknown at this stage. We explore the effect of alemtuzumab on intestinal intraepithelial lymphocytes (IELs and intestinal barrier function in cynomolgus model to explain the reason of infection following alemtuzumab treatment. Methods: Twelve male cynomolguses were randomly assigned to either a treatment or control group. The treatment group received alemtuzumab (3 mg/kg, intravenous injection while the control group received the same volume of physiological saline. Intestinal IELs were isolated from the control group and the treatment group (on day 9, 35, and 70 after treatment for counting and flow cytometric analysis. Moreover, intestinal permeability was monitored by enzymatic spectrophotometric technique and enzyme-linked immunosorbent assay. Results: The numbers of IELs were decreased significantly on day 9 after treatment compared with the control group (0.35 ± 0.07 × 10 8 and 1.35 ± 0.09 × 10 8 , respectively; P < 0.05 and were not fully restored until day 70 after treatment. There were significant differences among four groups considering IELs subtypes. In addition, the proportion of apoptotic IELs after alemtuzumab treatment was significantly higher than in the control group (22.01 ± 3.67 and 6.01 ± 1.42, respectively; P < 0.05. Moreover, the concentration of D-lactate and endotoxin was also increased significantly on day 9 after treatment. Conclusions: Alemtuzumab treatment depletes lymphocytes in the peripheral blood and intestine of cynomolgus model. The induction of apoptosis is an important mechanism of lymphocyte depletion after alemtuzumab treatment. Notably, intestinal barrier function may be disrupted after
Polaron Energy and Effective Mass in Parabolic Quantum Wells
WANG Zhi-Ping; LIANG Xi-Xia
2005-01-01
@@ The energy and effective mass of a polaron in a parabolic quantum well are studied theoretically by using LLP-like transformations and a variational approach. Numerical results are presented for the polaron energy and effective mass in the GaAs/Al0.3Ga0.7As parabolic quantum well. The results show that the energy and the effective mass of the polaron both have their maxima in the finite parabolic quantum well but decrease monotonously in the infinite parabolic quantum well with the increasing well width. It is verified that the bulk longitudinal optical phonon mode approximation is an adequate formulation for the electron-phonon coupling in parabolic quantum well structures.
Optical, Energetic and Exergetic Analyses of Parabolic Trough Collectors
(O)ZT(U)RK Murat; (C)(I)(C)EK BEZ(I)R Nalan; (O)ZEK Nuri
2007-01-01
Parabolic trough collectors generate thermal energy from solar energy. Especially, they are very convenient for applications in high temperature solar power systems. To determine the design parameters, parabolic trough collectors must be analysed with optical analysis. In addition, thermodynamics (energy and exergy) analysis in the development of an energy efficient system must be achieved. Solar radiation passes through Earth's atmosphere until it reaches on Earth's surface and is focused from the parabolic trough collector to the tube receiver with a transparent insulated envelope. All of them constitute a complex mechanism. We investigate the geometry of parabolic trough reflector and characteristics of solar radiation to the reflecting surface through Earth's atmosphere, and calculate the collecting total energy in the receiver. The parabolic trough collector,of which design parameters are given, is analysed in regard to the energy and exergy analysis considering the meteorological specification in May, June, July and August in Isparta/Turkey, and the results are presented.
Xiong, Qingrong; Joseph, Claudia; Schmeide, Katja; Jivkov, Andrey P
2015-11-11
Compacted clays are considered as excellent candidates for barriers to radionuclide transport in future repositories for nuclear waste due to their very low hydraulic permeability. Diffusion is the dominant transport mechanism, controlled by a nano-scale pore system. Assessment of the clays' long-term containment function requires adequate modelling of such pore systems and their evolution. Existing characterisation techniques do not provide complete pore space information for effective modelling, such as pore and throat size distributions and connectivity. Special network models for reactive transport are proposed here using the complimentary character of the pore space and the solid phase. This balances the insufficient characterisation information and provides the means for future mechanical-physical-chemical coupling. The anisotropy and heterogeneity of clays is represented using different length parameters and percentage of pores in different directions. Resulting networks are described as mathematical graphs with efficient discrete calculus formulation of transport. Opalinus Clay (OPA) is chosen as an example. Experimental data for the tritiated water (HTO) and U(vi) diffusion through OPA are presented. Calculated diffusion coefficients of HTO and uranium species are within the ranges of the experimentally determined data in different clay directions. This verifies the proposed pore network model and validates that uranium complexes are diffusing as neutral species in OPA. In the case of U(vi) diffusion the method is extended to account for sorption and convection. Rather than changing pore radii by coarse grained mathematical formula, physical sorption is simulated in each pore, which is more accurate and realistic.
A financing model to solve financial barriers for implementing green building projects.
Lee, Sanghyo; Lee, Baekrae; Kim, Juhyung; Kim, Jaejun
2013-01-01
Along with the growing interest in greenhouse gas reduction, the effect of greenhouse gas energy reduction from implementing green buildings is gaining attention. The government of the Republic of Korea has set green growth as its paradigm for national development, and there is a growing interest in energy saving for green buildings. However, green buildings may have financial barriers that have high initial construction costs and uncertainties about future project value. Under the circumstances, governmental support to attract private funding is necessary to implement green building projects. The objective of this study is to suggest a financing model for facilitating green building projects with a governmental guarantee based on Certified Emission Reduction (CER). In this model, the government provides a guarantee for the increased costs of a green building project in return for CER. And this study presents the validation of the model as well as feasibility for implementing green building project. In addition, the suggested model assumed governmental guarantees for the increased cost, but private guarantees seem to be feasible as well because of the promising value of the guarantee from CER. To do this, certification of Clean Development Mechanisms (CDMs) for green buildings must be obtained.
A Financing Model to Solve Financial Barriers for Implementing Green Building Projects
Sanghyo Lee
2013-01-01
Full Text Available Along with the growing interest in greenhouse gas reduction, the effect of greenhouse gas energy reduction from implementing green buildings is gaining attention. The government of the Republic of Korea has set green growth as its paradigm for national development, and there is a growing interest in energy saving for green buildings. However, green buildings may have financial barriers that have high initial construction costs and uncertainties about future project value. Under the circumstances, governmental support to attract private funding is necessary to implement green building projects. The objective of this study is to suggest a financing model for facilitating green building projects with a governmental guarantee based on Certified Emission Reduction (CER. In this model, the government provides a guarantee for the increased costs of a green building project in return for CER. And this study presents the validation of the model as well as feasibility for implementing green building project. In addition, the suggested model assumed governmental guarantees for the increased cost, but private guarantees seem to be feasible as well because of the promising value of the guarantee from CER. To do this, certification of Clean Development Mechanisms (CDMs for green buildings must be obtained.
Nozaki, Daijiro; Avdoshenko, Stanislav M.; Sevincli, Haldun;
2013-01-01
to predict the appearance of quantum interference, Fano resonances or anti- resonances, and its position in the conductance spectrum by introducing a simple graphical representation (parabolic model). Using it we can easily visualize the relation between the key electronic parameters and the positions...... of normal resonant peaks and anti-resonant peaks induced by quantum interference in the conductance spectrum. We also demonstrate Fano and anti-resonance in T-shaped molecular junctions using a simple tight-binding model. This parabolic model enables one to infer on-site energies of T-shaped molecules...
Ouyang, Wenjun; Subotnik, Joseph E
2017-05-07
Using the Anderson-Holstein model, we investigate charge transfer dynamics between a molecule and a metal surface for two extreme cases. (i) With a large barrier, we show that the dynamics follow a single exponential decay as expected; (ii) without any barrier, we show that the dynamics are more complicated. On the one hand, if the metal-molecule coupling is small, single exponential dynamics persist. On the other hand, when the coupling between the metal and the molecule is large, the dynamics follow a biexponential decay. We analyze the dynamics using the Smoluchowski equation, develop a simple model, and explore the consequences of biexponential dynamics for a hypothetical cyclic voltammetry experiment.
Safety-barrier diagrams as a tool for modelling safety of hydrogen applications
Duijm, Nijs Jan; Markert, Frank
2009-01-01
Safety-barrier diagrams have proven to be a useful tool in documenting the safety measures taken to prevent incidents and accidents in process industry. Especially during the introduction of new hydrogen technologies or applications, as e.g. hydrogen refuelling stations, safety-barrier diagrams...... are considered a valuable supplement to other traditional risk analysis tools to support the communication with authorities and other stakeholders during the permitting process. Another advantage of safety-barrier diagrams is that they highlight the importance of functional and reliable safety barriers in any...... system and here is a direct focus on those barriers that need to be subject to safety management in terms of design and installation, operational use, inspection and monitoring, and maintenance. Safety-barrier diagrams support both quantitative and qualitative approaches. The paper will describe...
Safety-barrier diagrams as a tool for modelling safety of hydrogen applications
Duijm, Nijs Jan; Markert, Frank
2009-01-01
system and here is a direct focus on those barriers that need to be subject to safety management in terms of design and installation, operational use, inspection and monitoring, and maintenance. Safety-barrier diagrams support both quantitative and qualitative approaches. The paper will describe......Safety-barrier diagrams have proven to be a useful tool in documenting the safety measures taken to prevent incidents and accidents in process industry. Especially during the introduction of new hydrogen technologies or applications, as e.g. hydrogen refuelling stations, safety-barrier diagrams...... are considered a valuable supplement to other traditional risk analysis tools to support the communication with authorities and other stakeholders during the permitting process. Another advantage of safety-barrier diagrams is that they highlight the importance of functional and reliable safety barriers in any...
Concentration phenomena in the semilinear parabolic equation
TAN; Zhong
2001-01-01
［1］Fujita, H., On the blowing up of solutions of the Chauch problem for u=Δu+u1+α, J. Fac. Sci. Univ. Tokyo Sect. I, 966, 3: 09.［2］Ni, W. -M., Sacks, P. E., Tavantzis, J., On the asymptotic behavior of solutions of certain quasilinear equations of parabolic type, J. Differential Equations, 984, 54: 97.［3］Cazenave, T., Lions, P. L., Solutions globales d'equations de la chaleur semilineaires, Comm. in Partial Differential Equations, 984, 9(0): 955.［4］Giga, Y., A bound for global solutions of semilinear heat equations, Commun. Math. Phys., 986, 03: 45.［5］Galaktionov, V., Vazquez, J. L., Continuation of blow-up solutions of nonlinear heat equations in several space dimensions, Comm. Pure Appl. Math., 997, 50: .［6］Rey, O., The role of the Green's function in a nonlinear elliptic equation involving the critical Sobolev exponent, J. Func. Anal., 990, 89: .［7］Wei Juncheng, Asymptotic behavior of least energy solution to a semilinear Dirichlet problem near the critical exponent, J. Math. Soc. Japan, 998, 50(): 39.［8］Lions, P. L., The concentration-compactness principle in the calculus of variations, The limit case ,2, Rev. Mat. Iberoamerioana, 985, : 45, 45.［9］Brezis, H., Elliptic equations with limiting Sobolev exponents——the impact of topology, Commun. Pure and Appl. Math., 986, XXXXIX: S7.［10］Sacks, J., Uhlenbeck, K., The existence of minimal immersions of 2-spheres, Ann. Math., 98, 3: .［11］Zhu Xiping, Nontrivial solutions of quasilinear elliptic equation involving critical growth, Science in China (in Chinese), Ser. A, 988, (3): 225.［12］Pohozaev, S. I., Eigenfunctions of the equation -Δu+λf(u)=0, Soviet. Math. Dold., 965, 6: 408.［13］Gidas, B., Ni, W. -M., Nirenberg, L., Symmetry and related properties via the maximum principle, Comm. Math. Phys., 979, 68: 209.［14］Ni, W. -M., Sacks, P. E., Singular behaviour in nonlinear parabolic equations, Tran. of the AMS, 985, 287(2): 657.［15］Ni, W. -M., Sacks, P. E
Yan, Na; Baas, Andreas C. W.
2016-04-01
Parabolic dunes are a quintessential example of the co-evolution of soil, landform, and vegetation, and they are found around the world, on coasts, river valleys, lake shores, and margins of deserts and steppes. These areas are often sensitive to changes in natural and anthropogenic forcings and socio-economic activities. Some studies have indicated parabolic dunes can lose vegetation and transform into barchan and transverse dunes by environmental change such as decreased precipitation or lowered water table, as well as anthropogenic stress such as increased burning and grazing. These transformations and shifts between states of eco-geomorphic systems may have significant implications on land management and social-economic development. This study utilises the Extended-DECAL - parameterised by field measurements of dune topography and vegetation characteristics combined with remote sensing - to explore how increases in drought stress, wind strength, and grazing stress may lead to the activation of stabilised parabolic dunes into highly mobile barchans. The modelling results show that the mobility of an initial parabolic dune at the outset of perturbations determines to a large extent the capacity of a system to absorb the environmental change, and a slight increase in vegetation cover of an initial parabolic dune can increase the activation threshold significantly. Plants with a higher deposition tolerance increase the activation threshold for the climatic impact and sand transport rate, whereas the erosion tolerance of plants influences the patterns of resulting barchans. The change in the characteristics of eco-geomorphic interaction zones may indirectly reflect the dune stability and predict an ongoing transformation, whilst the activation angle may be potentially used as a proxy of environmental stresses. In contrast to the natural environmental changes which tend to affect relatively weak and young plants, grazing stress can exert a broader impact on all
Iveta Novakova
Full Text Available The aim of this work was to conduct a comprehensive study about the transport properties of NSAIDs across the blood-brain barrier (BBB in vitro. Transport studies with celecoxib, diclofenac, ibuprofen, meloxicam, piroxicam and tenoxicam were accomplished across Transwell models based on cell line PBMEC/C1-2, ECV304 or primary rat brain endothelial cells. Single as well as group substance studies were carried out. In group studies substance group compositions, transport medium and serum content were varied, transport inhibitors verapamil and probenecid were added. Resulted permeability coefficients were compared and normalized to internal standards diazepam and carboxyfluorescein. Transport rankings of NSAIDs across each model were obtained. Single substance studies showed similar rankings as corresponding group studies across PBMEC/C1-2 or ECV304 cell layers. Serum content, glioma conditioned medium and inhibitors probenecid and verapamil influenced resulted permeability significantly. Basic differences of transport properties of the investigated NSAIDs were similar comparing all three in vitro BBB models. Different substance combinations in the group studies and addition of probenecid and verapamil suggested that transporter proteins are involved in the transport of every tested NSAID. Results especially underlined the importance of same experimental conditions (transport medium, serum content, species origin, cell line for proper data comparison.
Abdul-Aziz, Ali; Najafi, Ali; Abdi, Frank; Bhatt, Ramakrishna T.; Grady, Joseph E.
2014-03-01
Protection of Ceramic Matrix Composites (CMCs) is rather an important element for the engine manufacturers and aerospace companies to help improve the durability of their hot engine components. The CMC's are typically porous materials which permits some desirable infiltration that lead to strength enhancements. However, they experience various durability issues such as degradation due to coating oxidation. These concerns are being addressed by introducing a high temperature protective system, Environmental Barrier Coating (EBC) that can operate at temperature applications1, 3 In this paper, linear elastic progressive failure analyses are performed to evaluate conditions that would cause crack initiation in the EBC. The analysis is to determine the overall failure sequence under tensile loading conditions on different layers of material including the EBC and CMC in an attempt to develop a life/failure model. A 3D finite element model of a dogbone specimen is constructed for the analyses. Damage initiation, propagation and final failure is captured using a progressive failure model considering tensile loading conditions at room temperature. It is expected that this study will establish a process for using a computational approach, validated at a specimen level, to predict reliably in the future component level performance without resorting to extensive testing.
Modelling Growth of Juvenile Crown-of-Thorns Starfish on the Northern Great Barrier Reef
Jennifer Wilmes
2016-12-01
Full Text Available The corallivorous crown-of-thorns starfish (Acanthaster spp. is a major cause of coral mortality on Indo-Pacific reefs. Despite considerable research into the biology of crown-of-thorns starfish, our understanding of the early post-settlement life stage has been hindered by the small size and cryptic nature of recently settled individuals. Most growth rates are derived from either laboratory studies or field studies conducted in Fiji and Japan. The Great Barrier Reef (GBR is currently experiencing its fourth recorded outbreak and population models to inform the progression of outbreaks lack critical growth rates of early life history stages. High numbers of 0+ year juveniles (n = 3532 were measured during extensive surveys of 64 reefs on the northern GBR between May and December 2015. An exponential growth model was fitted to the size measurement data to estimate monthly ranges of growth rates for 0+ year juveniles. Estimated growth rates varied considerably and increased with age (e.g., 0.028–0.041 mm·day−1 for one-month-old juveniles versus 0.108–0.216 mm·day−1 for twelve-month-old juveniles. This pioneering study of 0+ year juveniles on the GBR will inform population models and form the basis for more rigorous ongoing research to understand the fate of newly settled Acanthaster spp.
Thermal Conductivity in Suspension Sprayed Thermal Barrier Coatings: Modeling and Experiments
Ganvir, Ashish; Kumara, Chamara; Gupta, Mohit; Nylen, Per
2016-12-01
Axial suspension plasma spraying (ASPS) can generate microstructures with higher porosity and pores in the size range from submicron to nanometer. ASPS thermal barrier coatings (TBC) have already shown a great potential to produce low thermal conductivity coatings for gas turbine applications. It is important to understand the fundamental relationships between microstructural defects in ASPS coatings such as crystallite boundaries, porosity etc. and thermal conductivity. Object-oriented finite element (OOF) analysis has been shown as an effective tool for evaluating thermal conductivity of conventional TBCs as this method is capable of incorporating the inherent microstructure in the model. The objective of this work was to analyze the thermal conductivity of ASPS TBCs using experimental techniques and also to evaluate a procedure where OOF can be used to predict and analyze the thermal conductivity for these coatings. Verification of the model was done by comparing modeling results with the experimental thermal conductivity. The results showed that the varied scaled porosity has a significant influence on the thermal conductivity. Smaller crystallites and higher overall porosity content resulted in lower thermal conductivity. It was shown that OOF could be a powerful tool to predict and rank thermal conductivity of ASPS TBCs.
Thermal Conductivity in Suspension Sprayed Thermal Barrier Coatings: Modeling and Experiments
Ganvir, Ashish; Kumara, Chamara; Gupta, Mohit; Nylen, Per
2017-01-01
Axial suspension plasma spraying (ASPS) can generate microstructures with higher porosity and pores in the size range from submicron to nanometer. ASPS thermal barrier coatings (TBC) have already shown a great potential to produce low thermal conductivity coatings for gas turbine applications. It is important to understand the fundamental relationships between microstructural defects in ASPS coatings such as crystallite boundaries, porosity etc. and thermal conductivity. Object-oriented finite element (OOF) analysis has been shown as an effective tool for evaluating thermal conductivity of conventional TBCs as this method is capable of incorporating the inherent microstructure in the model. The objective of this work was to analyze the thermal conductivity of ASPS TBCs using experimental techniques and also to evaluate a procedure where OOF can be used to predict and analyze the thermal conductivity for these coatings. Verification of the model was done by comparing modeling results with the experimental thermal conductivity. The results showed that the varied scaled porosity has a significant influence on the thermal conductivity. Smaller crystallites and higher overall porosity content resulted in lower thermal conductivity. It was shown that OOF could be a powerful tool to predict and rank thermal conductivity of ASPS TBCs.
Darryl Christopher Gidyk
2015-07-01
Full Text Available Sporadic Alzheimer's disease is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless studies have been conducted however the details of this disease remain largely unknown. Rodent models provide opportunities to investigate certain aspects of AD that cannot be ethically studied in humans. These animal models vary from study to study and have provided some insight, but no real advancements in the prevention or treatment of the disease. In this Hypothesis and Theory paper, we discuss what we perceive as barriers to impactful discovery in rodent AD research and we offer solutions for moving forward. Although no single model of AD is capable of providing the solution to the growing epidemic of the disease, we encourage a comprehensive approach that acknowledges the complex etiology of AD with the goal of enhancing the bidirectional translatability from bench to bedside and vice versa.
槽式太阳能聚热器风载荷数值模拟研究%Wind Load Simulation of a Parabolic Solar Collector
胡摇; 陈小安; 吴国洋; 谭惠文
2012-01-01
Parabolic collector, an important equipment of the trough solar power, is quite sensitive to wind loads for it has a light and compact structure. It can fully grasp the exact figures of the wind loads exerting to the parabolic collector that counts. Therefore, the stent of the heliostat can be optimally designed. In this paper, the computational model of the parabolic collector is established according to the theory of Computational Fluid Dynamics （CFD）. The trough parabolic collector at different angles, different wind speed and the impacts of the gap between the different parabolic collector board on the wind load are calculated. The results show that the changes of the wind speed and angles of the parabolic collector have a great influence on the load while changing the gap between parabolic collector almost gets a constant wind load.%采用计算流体力学（CFD）理论建立了计算模型，对槽式太阳能聚热器不同角度、不同风速、聚热器板之间不同缝隙对风载荷的影响进行了分析。结果表明：聚热器随风速和角度变化对载荷影响较大，聚热器之间缝隙对风载荷影响几乎不变.
Wolff, Anette; Antfolk, Maria; Brodin, Birger;
2015-01-01
The societal need for new central nervous system (CNS) medicines is substantial, because of the global increase in life expectancy and the accompanying increase in age-related CNS diseases. Low blood-brain barrier (BBB) permeability has been one of the major causes of failure for new CNS drug...... candidates. There has therefore been a great interest in cell models, which mimic BBB permeation properties. In this review, we present an overview of the performance of monocultured, cocultured, and triple-cultured primary cells and immortalized cell lines, including key parameters such as transendothelial......-of-the-art models and it was noted that, although they show great promise, these systems have not yet reached beyond the proof-of-concept stage. In general, it was found that there were large variations in experimental protocols, BBB phenotype markers, and paracellular flux markers used. It is the author's opinion...
Modelling the fate of marine debris along a complex shoreline: Lessons from the Great Barrier Reef
Critchell, K.; Grech, A.; Schlaefer, J.; Andutta, F. P.; Lambrechts, J.; Wolanski, E.; Hamann, M.
2015-12-01
The accumulation of floating anthropogenic debris in marine and coastal areas has environmental, economic, aesthetic, and human health impacts. Until now, modelling the transport of such debris has largely been restricted to the large-scales of open seas. We used oceanographic modelling to identify potential sites of debris accumulation along a rugged coastline with headlands, islands, rocky coasts and beaches. Our study site was the Great Barrier Reef World Heritage Area that has an emerging problem with debris accumulation. We found that the classical techniques of modelling the transport of floating debris models are only moderately successful due to a number of unknowns or assumptions, such as the value of the wind drift coefficient, the variability of the oceanic forcing and of the wind, the resuspension of some floating debris by waves, and the poorly known relative contribution of floating debris from urban rivers and commercial and recreational shipping. Nevertheless the model was successful in reproducing a number of observations such as the existence of hot spots of accumulation. The orientation of beaches to the prevailing wind direction affected the accumulation rate of debris. The wind drift coefficient and the exact timing of the release of the debris at sea affected little the movement of debris originating from rivers but it affected measurably that of debris originating from ships. It was thus possible to produce local hotspot maps for floating debris, especially those originating from rivers. Such modelling can be used to inform local management decisions, and it also identifies likely priority research areas to more reliably predict the trajectory and landing points of floating debris.
Bicker, Joana; Alves, Gilberto; Fortuna, Ana; Falcão, Amílcar
2014-08-01
During the research and development of new drugs directed at the central nervous system, there is a considerable attrition rate caused by their hampered access to the brain by the blood-brain barrier. Throughout the years, several in vitro models have been developed in an attempt to mimic critical functionalities of the blood-brain barrier and reliably predict the permeability of drug candidates. However, the current challenge lies in developing a model that retains fundamental blood-brain barrier characteristics and simultaneously remains compatible with the high throughput demands of pharmaceutical industries. This review firstly describes the roles of all elements of the neurovascular unit and their influence on drug brain penetration. In vitro models, including non-cell based and cell-based models, and in vivo models are herein presented, with a particular emphasis on their methodological aspects. Lastly, their contribution to the improvement of brain drug delivery strategies and drug transport across the blood-brain barrier is also discussed.
Parabolic refined invariants and Macdonald polynomials
Chuang, Wu-yen; Donagi, Ron; Pantev, Tony
2013-01-01
A string theoretic derivation is given for the conjecture of Hausel, Letellier, and Rodriguez-Villegas on the cohomology of character varieties with marked points. Their formula is identified with a refined BPS expansion in the stable pair theory of a local root stack, generalizing previous work of the first two authors in collaboration with G. Pan. Haiman's geometric construction for Macdonald polynomials is shown to emerge naturally in this context via geometric engineering. In particular this yields a new conjectural relation between Macdonald polynomials and refined local orbifold curve counting invariants. The string theoretic approach also leads to a new spectral cover construction for parabolic Higgs bundles in terms of holomorphic symplectic orbifolds.
Antireflection Pyrex envelopes for parabolic solar collectors
McCollister, H. L.; Pettit, R. B.
1983-11-01
Antireflective (AR) coatings, applied to the glass envelopes used in parabolic trough solar collectors around the receiver tube in order to reduce thermal losses, can increase solar transmittance by 7 percent. An AR surface has been formed on Pyrex by first heat treating the glass to cause a compositional phase separation, removing a surface layer after heat treatment through the use of a preetching solution, and finally etching in a solution that contains hydrofluorosilic and ammonium bifluoride acids. AR-coated samples with solar transmittance values of more than 0.97, by comparison to an untreated sample value of 0.91, have been obtained for the 560-630 C range of heat treatment temperatures. Optimum values have also been determined for the other processing parameters.
Photon-Atom Coupling with Parabolic Mirrors
Sondermann, Markus
2014-01-01
Efficient coupling of light to single atomic systems has gained considerable attention over the past decades. This development is driven by the continuous growth of quantum technologies. The efficient coupling of light and matter is an enabling technology for quantum information processing and quantum communication. And indeed, in recent years much progress has been made in this direction. But applications aside, the interaction of photons and atoms is a fundamental physics problem. There are various possibilities for making this interaction more efficient, among them the apparently 'natural' attempt of mode-matching the light field to the free-space emission pattern of the atomic system of interest. Here we will describe the necessary steps of implementing this mode-matching with the ultimate aim of reaching unit coupling efficiency. We describe the use of deep parabolic mirrors as the central optical element of a free-space coupling scheme, covering the preparation of suitable modes of the field incident on...
Analysis of the Quality of Parabolic Flight
Lambot, Thomas; Ord, Stephan F.
2016-01-01
Parabolic flight allows researchers to conduct several micro-gravity experiments, each with up to 20 seconds of micro-gravity, in the course of a single day. However, the quality of the flight environment can vary greatly over the course of a single parabola, thus affecting the experimental results. Researchers therefore require knowledge of the actual flight environment as a function of time. The NASA Flight Opportunities program (FO) has reviewed the acceleration data for over 400 parabolas and investigated the level of micro-gravity quality. It was discovered that a typical parabola can be segmented into multiple phases with different qualities and durations. The knowledge of the microgravity characteristics within the parabola will prove useful when planning an experiment.
New method to solve electromagnetic parabolic equation
赵小峰; 黄思训; 康林春
2013-01-01
This paper puts forward a new method to solve the electromagnetic parabolic equation (EMPE) by taking the vertically-layered inhomogeneous characteristics of the atmospheric refractive index into account. First, the Fourier transform and the convo-lution theorem are employed, and the second-order partial differential equation, i.e., the EMPE, in the height space is transformed into first-order constant coeﬃcient differential equations in the frequency space. Then, by use of the lower triangular characteristics of the coeﬃcient matrix, the numerical solutions are designed. Through constructing ana-lytical solutions to the EMPE, the feasibility of the new method is validated. Finally, the numerical solutions to the new method are compared with those of the commonly used split-step Fourier algorithm.
Heat Loss Testing of Schott's 2008 PTR70 Parabolic Trough Receiver
Burkholder, Frank [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kutscher, Chuck [National Renewable Energy Lab. (NREL), Golden, CO (United States)
2009-05-01
Two Schott 2008 model year PTR70 HCEs were tested on NREL's heat loss test stand from 100 - 500 deg C in 50 deg C increments. Absorber emittance was determined from the laboratory testing so that the performance of the HCEs could be modeled in a parabolic trough collector. Collector/HCE simulation results for many different field operation conditions were used to create heat loss correlationcoefficients for Excelergy and SAM. SAM estimates that the decreased emittance of the 2008 PTR70 will decrease the LCOE for parabolic trough power plants by 0.5 cents/kWh and increase the electricity generated by 5% relative to previous PTR70s. These conclusions assume that the 2008 PTR70 is supplied at the same cost and with the same optical performance as earlier PTR70 models.
Prasanth S. Poduval
2015-08-01
Full Text Available Abstract - The aim of the authors is to present a review of literature of Total Productive Maintenance and the barriers in implementation of Total Productive Maintenance TPM. The paper begins with a brief description of TPM and the barriers in implementation of TPM. Interpretive Structural Modeling ISM and its role in analyzing the barriers in TPM implementation is explained in brief. Applications of ISM in analyzing issues in various fields are highlighted with special emphasis on TPM. The paper moves on to introduction to Structural Equation Modeling SEM and its role in validating ISM in analyzing barriers in implementation of TPM. The paper concludes with a gap analysis from the current literature research that can be carried out and expected outcomes from the proposed research.
Sener Parabolic trough Collector Design and Testing
Castaneda, N.; Vazquez, J.; Domingo, M.
2006-07-01
Parabolic trough technology is nowadays the most extended solar system for electricity production or steam generation for industrial processes. It is basically composed of a collector field which converts solar irradiation into thermal energy- and a conventional thermal-toelectric conversion Rankine cycle. In these plants, a storage system can be implemented in order to increase plant production. Collector field represents more than half the total plant cost. Therefore, SENER has made an effort to improve current state of the art of parabolic trough collector (PTC from now on) design in order to reduce plant costs. Main characteristic of SENER design lies on the use of a torque tube as the central body of the collector. This tube is made of steel sheet, with a thickness depending on wind load requirements on the collector. This concept is very cost-effective, since the man-power needed to manufacture the tube has been minimized. Continuous cylindrical shape of the torque tube provides a high torsional stiffness, which is one of the main parameters affecting collector optical efficiency. Cantilever arms connect the mirrors to the central torque tube. These components are usually made of welded tube profiles. In SENER's new design, these cantilever arms are made using metal sheet stamping techniques (SENER patent), thus reducing manufacturing and mounting costs. SENER PTC module (called SENERTROUGH) is 12 meters long and has an aperture width of 5,76 m. HCE and curved mirrors existing in the market - as well as new products from different manufacturers - can be easily attached to collector structure. Two prototype modules of SENERTROUGH have been mounted and tested at the CIEMAT-PSA facilities. Several performance tests were performed in order to assure the validity of the concept. (Author)
LI Ke-Ping; YU Chao-Fan; GAO Zi-You; LIANG Guo-Dong; YU Xiao-Min
2008-01-01
Based on the picture of nonlinear and non-parabolic symmetry response, I.e., △n2( I) ≈ p(αo -α1x- α2x2), we propose a model for the transversal beam intensity distribution of the nonlocal spatial soliton. In this model, as a convolution response with non-parabolic symmetry, △n2( I) ≈ p(b0+b1 f - b2 f2 with b2/b1 > 0 is assumed. Furthermore, instead of the wave function Ψ, the high-order nonlinear equation for the beam intensity distribution f has been derived and the bell-shaped soliton solution with the envelope form has been obtained. The results demonstrate that, since the existence of the terms of non-parabolic response, the nonlocal spatial soliton has the bistable state solution. If thefrequency shift of wave number β satisfies 0 0 has been demonstrated.
Modeling, analysis, and validation of an active T-shaped noise barrier.
Fan, Rongping; Su, Zhongqing; Cheng, Li
2013-09-01
With ever-increasing land traffic, abatement of traffic noise using noise barriers remains significant, yet it is a challenging task due to spatial competition with other infrastructure. In this study, a deep insight into the diffraction characteristics of acoustic fields near noise barriers of various geometries and surface conditions was achieved using numerical simulations. A T-shaped passive noise barrier with acoustically soft upper surfaces was demonstrated to outperform other candidates in a middle- or high-frequency range. Based on attributes of the acoustic field diffracted by T-shaped barriers, an active control strategy was developed to revamp the T-shaped barrier, in which a filtered minimax algorithm was established to drive the secondary sound sources. This algorithm resulted in more uniformly distributed residual sound fields than a filtered-X least mean square algorithm. Performance of the actively controlled barrier was evaluated at different positions and spacings of secondary sound sources and error sensors, leading to a series of optimal criteria for the design of active noise barriers. A prototype was fabricated and validated experimentally, manifesting particular effectiveness in insulating low-frequency noise, supplementing well the capacity of a passive T-shaped barrier which is effective in the middle- or high-frequency range.
The pivotal role of astrocytes in an in-vitro stroke model of the blood-brain barrier
Winfried eNeuhaus
2014-10-01
Full Text Available Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in-vitro disease models of the blood-brain barrier could be very helpful. To mimic in-vitro stroke conditions we have established a blood-brain barrier in-vitro model based on mouse cell line cerebEND and applied oxygen/glucose deprivation (OGD. The role of astrocytes in this disease model was investigated by using cell line C6. Transwell studies pointed out that addition of astrocytes during OGD increased the barrier damage significantly in comparison to the endothelial monoculture shown by changes of transendothelial electrical resistance as well as fluorescein permeability data. Analysis on mRNA and protein levels by qPCR, western blotting and immunofluorescence microscopy of tight junction molecules claudin-3,-5,-12, occludin and ZO-1 revealed that their regulation and localisation is associated with the functional barrier breakdown. Furthermore, soluble factors of astrocytes, OGD and their combination were able to induce changes of functionality and expression of ABC-transporters Abcb1a (P-gp, Abcg2 (bcrp and Abcc4 (mrp4. Moreover, the expression of proteases (matrixmetalloproteinases MMP-2, MMP-3 and MMP-9 and t-PA as well as of their endogenous inhibitors (TIMP-1, TIMP-3, PAI-1 was altered by astrocyte factors and OGD which resulted in significant changes of total MMP and t-PA activity. Morphological rearrangements induced by OGD and treatment with astrocyte factors were confirmed at a nanometer scale using atomic force microscopy. In conclusion, astrocytes play a major role in blood-brain barrier breakdown during OGD in vitro.
Nobrega, Marcelo Medre; Bona, Evandro; Yamashita, Fabio
2013-10-01
Nowadays, the production of biodegradable starch-based films is of great interest because of the growing environmental concerns regarding pollution and the need to reduce dependence on the plastics industry. A broad view of the role of different components, added to starch-based films to improve their properties, is required to guide the future development. The self-organizing maps (SOMs) provide comparisons that initially were complicated due to the large volume of the data. Furthermore, the construction of a model capable of predicting the mechanical and barrier properties of these films will accelerate the development of films with improved characteristics. The water vapor permeability (WVP) analysis using the SOM algorithm showed that the presence of glycerol is very important for films with low amounts of poly (butylene adipate co-terephthalate) and confirms the role of the equilibrium relative humidity in the determination of WVP. Considering the mechanical properties, the SOM analysis emphasizes the important role of poly (butylene adipate co-terephthalate) in thermoplastic starch based films. The properties of biodegradable films were predicted and optimized by using a multilayer perceptron coupled with a genetic algorithm, presenting a great correlation between the experimental and theoretical values with a maximum error of 24%. To improve the response of the model and to ensure the compatibility of the components more information will be necessary.
Barriers and facilitators to replicating an evidence-based palliative care model.
Davis, E Maxwell; Jamison, Paula; Brumley, Richard; Enguídanos, Susan
2006-01-01
Recognition of the difficulties involved in replicating evidence- based interventions is well documented in the literature within the medical field. Promising research findings are often not translated into practice, and if they are, there is a significant time gap between study conclusion and practice adoption. The purpose of this article is to describe the barriers and facilitators encountered by two managed care organizations while replicating an evidence-based end of life in-home palliative care model. Using Diffusion of Innovation Theory as a theoretical framework, results from focus groups and interviews with the project's clinical, administrative and research teams are presented and recommendations made for improving translational efforts. The process of replicating the end of life in-home palliative care model clearly illustrated the key elements required for successfully diffusing innovation. These key elements include marketing and communication, leadership, organizational support and training and mentorship. This qualitative process study provides clear, real world perspectives of the myriad of challenges encountered in replicating an evidence-based project.
Solid phase studies and geochemical modelling of low-cost permeable reactive barriers
Bartzas, Georgios, E-mail: gbartzas@metal.ntua.gr [Laboratory of Metallurgy, School of Mining and Metallurgical Engineering, National Technical University of Athens, Zografos Campus, 15780 Athens (Greece); Komnitsas, Kostas [Department of Mineral Resources Engineering, Technical University of Crete, 73100 Chania (Greece)
2010-11-15
A continuous column experiment was carried out under dynamic flow conditions in order to study the efficiency of low-cost permeable reactive barriers (PRBs) to remove several inorganic contaminants from acidic solutions. A 50:50 w/w waste iron/sand mixture was used as candidate reactive media in order to activate precipitation and promote sorption and reduction-oxidation mechanisms. Solid phase studies of the exhausted reactive products after column shutdown, using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD), confirmed that the principal Fe corrosion products identified in the reactive zone are amorphous iron (hydr)oxides (maghemite/magnetite and goethite), intermediate products (sulfate green rust), and amorphous metal sulfides such as amFeS and/or mackinawite. Geochemical modelling of the metal removal processes, including interactions between reactive media, heavy metal ions and sulfates, and interpretation of the ionic profiles was also carried out by using the speciation/mass transfer computer code PHREEQC-2 and the WATEQ4F database. Mineralogical characterization studies as well as geochemical modelling calculations also indicate that the effect of sulfate and silica sand on the efficiency of the reactive zone should be considered carefully during design and operation of low-cost field PRBs.
Gupta, Mohit; Kumara, Chamara; Nylén, Per
2017-08-01
Suspension plasma spraying (SPS) has been shown as a promising process to produce porous columnar strain tolerant coatings for thermal barrier coatings (TBCs) in gas turbine engines. However, the highly porous structure is vulnerable to crack propagation, especially near the topcoat-bondcoat interface where high stresses are generated due to thermal cycling. A topcoat layer with high toughness near the topcoat-bondcoat interface could be beneficial to enhance thermal cyclic lifetime of SPS TBCs. In this work, a bilayer coating system consisting of first a dense layer near the topcoat-bondcoat interface followed by a porous columnar layer was fabricated by SPS using Yttria-stabilised zirconia suspension. The objective of this work was to investigate if the bilayer topcoat architecture could enhance the thermal cyclic lifetime of SPS TBCs through experiments and to understand the effect of the column gaps/vertical cracks and the dense layer on the generated stresses in the TBC during thermal cyclic loading through finite element modeling. The experimental results show that the bilayer TBC had significantly higher lifetime than the single-layer TBC. The modeling results show that the dense layer and vertical cracks are beneficial as they reduce the thermally induced stresses which thus increase the lifetime.
Al-Shehri, A.; Favretto, M.E.; Ioannou, P.V.; Romero, I.A.; Couraud, P.O.; Weksler, B.B.; Parker, T.L.; Kallinteri, P.
2015-01-01
PURPOSE: Owing to restricted access of pharmacological agents into the brain due to blood brain barrier (BBB) there is a need: 1. to develop a more representative 3-D-co-culture model of tumor-BBB interaction to investigate drug and nanoparticle transport into the brain for diagnostic and therapeuti
Erdbrink, C.D.; Krzhizhanovskaya, V.V.; Sloot, P.M.A.; Klijn, F.; Schweckendiek, T.
2012-01-01
Operation of flood barrier gates is sometimes hampered by flow-induced vibrations. Although the physics is understood for specific gate types, it remains challenging to judge dynamic gate behaviour for unanticipated conditions. This paper presents a hybrid modelling system for predicting vibrations
Evaluation of US and UK Models in Simulating the Impact of Barriers on Near-Road Air Quality
The possibility that roadside noise barriers can act to mitigate traffic-related air pollution exposures for people living and working near major roadways is being considered in the context of public health protection. Air pollution dispersion models that can accurately simulate ...
Hom, J.; Dankbaar, J. W.; Schneider, T.; Cheng, S. -C.; Bredno, J.; Wintermark, M.
2009-01-01
BACKGROUND AND PURPOSE: A previous study demonstrated the need to use delayed acquisition rather than first-pass data for accurate blood-brain barrier permeability surface product (BBBP) calculation from perfusion CT (PCT) according to the Patlak model, but the optimal duration of the delayed acquis
Parabolic features and the erosion rate on Venus
Strom, Robert G.
1993-01-01
The impact cratering record on Venus consists of 919 craters covering 98 percent of the surface. These craters are remarkably well preserved, and most show pristine structures including fresh ejecta blankets. Only 35 craters (3.8 percent) have had their ejecta blankets embayed by lava and most of these occur in the Atla-Beta Regio region; an area thought to be recently active. parabolic features are associated with 66 of the 919 craters. These craters range in size from 6 to 105 km diameter. The parabolic features are thought to be the result of the deposition of fine-grained ejecta by winds in the dense venusian atmosphere. The deposits cover about 9 percent of the surface and none appear to be embayed by younger volcanic materials. However, there appears to be a paucity of these deposits in the Atla-Beta Regio region, and this may be due to the more recent volcanism in this area of Venus. Since parabolic features are probably fine-grain, wind-deposited ejecta, then all impact craters on Venus probably had these deposits at some time in the past. The older deposits have probably been either eroded or buried by eolian processes. Therefore, the present population of these features is probably associated with the most recent impact craters on the planet. Furthermore, the size/frequency distribution of craters with parabolic features is virtually identical to that of the total crater population. This suggests that there has been little loss of small parabolic features compared to large ones, otherwise there should be a significant and systematic paucity of craters with parabolic features with decreasing size compared to the total crater population. Whatever is erasing the parabolic features apparently does so uniformly regardless of the areal extent of the deposit. The lifetime of parabolic features and the eolian erosion rate on Venus can be estimated from the average age of the surface and the present population of parabolic features.
Parabolic features and the erosion rate on Venus
Strom, Robert G.
1993-01-01
The impact cratering record on Venus consists of 919 craters covering 98 percent of the surface. These craters are remarkably well preserved, and most show pristine structures including fresh ejecta blankets. Only 35 craters (3.8 percent) have had their ejecta blankets embayed by lava and most of these occur in the Atla-Beta Regio region; an area thought to be recently active. parabolic features are associated with 66 of the 919 craters. These craters range in size from 6 to 105 km diameter. The parabolic features are thought to be the result of the deposition of fine-grained ejecta by winds in the dense venusian atmosphere. The deposits cover about 9 percent of the surface and none appear to be embayed by younger volcanic materials. However, there appears to be a paucity of these deposits in the Atla-Beta Regio region, and this may be due to the more recent volcanism in this area of Venus. Since parabolic features are probably fine-grain, wind-deposited ejecta, then all impact craters on Venus probably had these deposits at some time in the past. The older deposits have probably been either eroded or buried by eolian processes. Therefore, the present population of these features is probably associated with the most recent impact craters on the planet. Furthermore, the size/frequency distribution of craters with parabolic features is virtually identical to that of the total crater population. This suggests that there has been little loss of small parabolic features compared to large ones, otherwise there should be a significant and systematic paucity of craters with parabolic features with decreasing size compared to the total crater population. Whatever is erasing the parabolic features apparently does so uniformly regardless of the areal extent of the deposit. The lifetime of parabolic features and the eolian erosion rate on Venus can be estimated from the average age of the surface and the present population of parabolic features.
Antonio, Raphaela N.; Rotunno Filho, Otto C. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Lab. de Hidrologia e Estudos do Meio Ambiente]. E-mail: otto@hidro.ufrj.br; Ruperti Junior, Nerbe J.; Lavalle Filho, Paulo F. Heilbron [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)]. E-mail: nruperti@cnen.gov.br
2005-07-01
This work proposes a mathematical model for the performance assessment of a typical radioactive waste disposal facility based on the consideration of a multiple barrier concept. The Generalized Integral Transform Technique is employed to solve the Advection-Dispersion mass transfer equation under the assumption of saturated one-dimensional flow, to obtain solute concentrations at given times and locations within the medium. A test-case is chosen in order to illustrate the performance assessment of several configurations of a multi barrier system adopted for the containment of sand contaminated with Ra-226 within a trench. (author)
Proceedings of the Fifth Parabolic Dish Solar Thermal Power Program
Lucas, J. W. (Editor)
1984-01-01
The proceedings of the Fifth Parabolic Dish Solar Thermal Power Program Annual Review are presented. The results of activities within the Parabolic Dish Technology and Module/Systems Development element of the Department of Energy's Solar Thermal Energy Systems Program were emphasized. Among the topics discussed were: overall Project and Program aspects, Stirling and Brayton module development, concentrator and engine/receiver development along with associated hardware and test results; distributed systems operating experience; international parabolic dish development activities; and non-DOE-sponsored domestic dish activities. Solar electric generation was also addressed.
Xiong, Yongjian; Wang, Jingyu; Chu, Hongwei; Chen, Dapeng; Guo, Huishu
2016-01-01
Salvianolic acid B (Sal B) is isolated from the traditional Chinese medical herb Salvia miltiorrhiza and is reported to have a wide range of therapeutic benefits. The aim of this study was to investigate the effects of Sal B on epithelial barrier dysfunction in rat colitis and to uncover related mechanisms. Rat colitis model was established by intracolonic administration of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS). The intestinal barrier function was evaluated by measuring the serum recovery of fluorescein isothiocyanate-4 kD dextran in vivo and transepithelial electrical resistance in vitro respectively. The protein expression related to intestinal barrier function was studied using western blotting. The effects of Sal B on inflammatory responses, oxidative damage and colitis recurrence were also studied in this study. The intestinal barrier dysfunction in colitis was reversed by Sal B, accompanied with the decrease of tight junction proteins, and the effect could be blocked by microRNA-1(miR-1) inhibition. The inflammatory responses, oxidative damage and colitis recurrence were also decreased by Sal B. The colitis symptoms and recurrences were ameliorated by Sal B, and restoration of impaired barrier function via downregulation of MLCK by miR-1 maybe involved in this effect. This study provides some novel insights into both of the pathological mechanisms and treatment alternatives of inflammatory bowel disease.
Parabolic Bundles on Algebraic Surfaces I -- The Donaldson-Uhlenbeck Compactification
V Balaji; A Dey; R Parthasarathi
2008-02-01
The aim of this paper is to construct the parabolic version of the Donaldson-Uhlenbeck compactification for the moduli space of parabolic stable bundles on an algebraic surface with parabolic structures along a divisor with normal crossing singularities. We prove the non-emptiness of the moduli space of parabolic stable bundles of rank 2.
Chuan Qiang CHEN; Bo Wen HU
2013-01-01
We study microscopic spacetime convexity properties of fully nonlinear parabolic partial differential equations.Under certain general structure condition,we establish a constant rank theorem for the spacetime convex solutions of fully nonlinear parabolic equations.At last,we consider the parabolic convexity of solutions to parabolic equations and the convexity of the spacetime second fundamental form of geometric flows.
Ellis, Horace; Alexander, Vinette
2016-06-01
There has been renewed, global interest in developing new and transformative models of facilitating access to high-quality, cost-effective, and individually-centered health care for severe mentally-ill (SMI) persons of diverse racial/ethnic, cultural and socioeconomic backgrounds. However, in our present-day health-service delivery systems, scholars have identified layers of barriers to widespread dispersal of well-needed mental health care both nationally and internationally. It is crucial that contemporary models directed at eradicating barriers to mental health services are interdisciplinary in context, design, scope, sequence, and best-practice standards. Contextually, nurses are well-positioned to influence the incorporation and integration of new concepts into operationally interdisciplinary, evidence-based care models with measurable outcomes. The aim of this concept paper is to use the available evidence to contextually explicate how the blended roles of psychiatric mental health (PMH) nursing can be influential in eradicating barriers to care and services for SMI persons through the integrated principles of collaboration, integration and service expansion across health, socioeconomic, and community systems. A large body of literature proposes that any best-practice standards aimed at eliminating barriers to the health care needs of SMI persons require systematic, well-coordinated interdisciplinary partnerships through evidence-based, high-quality, person-centered, and outcome-driven processes. Transforming the conceptual models of collaboration, integration and service expansion could be revolutionary in how care and services are coordinated and dispersed to populations across disadvantaged communities. Building on their longstanding commitment to individual and community care approaches, and their pivotal roles in research, education, leadership, practice, and legislative processes; PMH nurses are well-positioned to be both influential and instrumental in
Sampled-Data Fuzzy Control for Nonlinear Coupled Parabolic PDE-ODE Systems.
Wang, Zi-Peng; Wu, Huai-Ning; Li, Han-Xiong
2017-09-01
In this paper, a sampled-data fuzzy control problem is addressed for a class of nonlinear coupled systems, which are described by a parabolic partial differential equation (PDE) and an ordinary differential equation (ODE). Initially, the nonlinear coupled system is accurately represented by the Takagi-Sugeno (T-S) fuzzy coupled parabolic PDE-ODE model. Then, based on the T-S fuzzy model, a novel time-dependent Lyapunov functional is used to design a sampled-data fuzzy controller such that the closed-loop coupled system is exponentially stable, where the sampled-data fuzzy controller consists of the ODE state feedback and the PDE static output feedback under spatially averaged measurements. The stabilization condition is presented in terms of a set of linear matrix inequalities. Finally, simulation results on the control of a hypersonic rocket car are given to illustrate the effectiveness of the proposed design method.
Williams, Benjamin B; Tebbutt, Niall C; Buchert, Michael; Putoczki, Tracy L; Doggett, Karen; Bao, Shisan; Johnstone, Cameron N; Masson, Frederick; Hollande, Frederic; Burgess, Antony W; Scott, Andrew M; Ernst, Matthias; Heath, Joan K
2015-08-01
The cells of the intestinal epithelium provide a selectively permeable barrier between the external environment and internal tissues. The integrity of this barrier is maintained by tight junctions, specialised cell-cell contacts that permit the absorption of water and nutrients while excluding microbes, toxins and dietary antigens. Impairment of intestinal barrier function contributes to multiple gastrointestinal disorders, including food hypersensitivity, inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Glycoprotein A33 (GPA33) is an intestinal epithelium-specific cell surface marker and member of the CTX group of transmembrane proteins. Roles in cell-cell adhesion have been demonstrated for multiple CTX family members, suggesting a similar function for GPA33 within the gastrointestinal tract. To test a potential requirement for GPA33 in intestinal barrier function, we generated Gpa33(-/-) mice and subjected them to experimental regimens designed to produce food hypersensitivity, colitis and CAC. Gpa33(-/-) mice exhibited impaired intestinal barrier function. This was shown by elevated steady-state immunosurveillance in the colonic mucosa and leakiness to oral TRITC-labelled dextran after short-term exposure to dextran sodium sulphate (DSS) to injure the intestinal epithelium. Gpa33(-/-) mice also exhibited rapid onset and reduced resolution of DSS-induced colitis, and a striking increase in the number of colitis-associated tumours produced by treatment with the colon-specific mutagen azoxymethane (AOM) followed by two cycles of DSS. In contrast, Gpa33(-/-) mice treated with AOM alone showed no increase in sporadic tumour formation, indicating that their increased tumour susceptibility is dependent on inflammatory stimuli. Finally, Gpa33(-/-) mice displayed hypersensitivity to food allergens, a common co-morbidity in humans with IBD. We propose that Gpa33(-/-) mice provide a valuable model to study the mechanisms linking intestinal
Barriers to knowledge sharing in Chinese healthcare referral services: an emergent theoretical model
Lihong Zhou
2016-02-01
Full Text Available Background: This paper reports on a research study that aims to identify and explain barriers to knowledge sharing (KS in the provision of healthcare referral services in Chinese healthcare organisations. Design: An inductive case study approach was employed, in which 24 healthcare professionals and workers from four healthcare organisations in the province of Hubei, Central China, were interviewed using semi-structured scripts. Results: Through data analysis, 14 KS barriers emerged in four main themes: interpersonal trust barriers, communication barriers, management and leadership barriers, and inter-institutional barriers. A cause–consequence analysis of the identified barriers revealed that three of them are at the core of the majority of problems, namely, the absence of national and local policies for inter-hospital KS, lack of a specific hospital KS requirement, and lack of mutual acquaintance. Conclusions: To resolve KS problems, it is of great importance that healthcare governance agencies, both at the national and regional levels, take leadership in the process of KS implementation by establishing specific and strong policies for inter-institutional KS in the referral process. This paper raises important issues that exceed academic interests and are important to healthcare professionals, hospital managers, and Information communication technology (ICT managers in hospitals, as well as healthcare politicians and policy makers.
Senthilkumar, M.; Elango, L.
2011-06-01
Groundwater modelling is widely used as a management tool to understand the behaviour of aquifer systems under different hydrological stresses, whether induced naturally or by humans. The objective of this study was to assess the effect of a subsurface barrier on groundwater flow in the Palar River basin, Tamil Nadu, southern India. Groundwater is supplied to a nearby nuclear power plant and groundwater also supplies irrigation, industrial and domestic needs. In order to meet the increasing demand for groundwater for the nuclear power station, a subsurface barrier/dam was proposed across Palar River to increase the groundwater heads and to minimise the subsurface discharge of groundwater into the sea. The groundwater model used in this study predicted that groundwater levels would increase by about 0.1-0.3 m extending out a distance of about 1.5-2 km from the upstream side of the barrier, while on the downstream side, the groundwater head would lower by about 0.1-0.2 m. The model also predicted that with the subsurface barrier in place the additional groundwater requirement of approximately 13,600 m3/day (3 million gallons (UK)/day) can be met with minimum decline in regional groundwater head.
Tracer kinetic modelling for DCE-MRI quantification of subtle blood–brain barrier permeability
Heye, Anna K.; Thrippleton, Michael J.; Armitage, Paul A.; Valdés Hernández, Maria del C.; Makin, Stephen D.; Glatz, Andreas; Sakka, Eleni; Wardlaw, Joanna M.
2016-01-01
There is evidence that subtle breakdown of the blood–brain barrier (BBB) is a pathophysiological component of several diseases, including cerebral small vessel disease and some dementias. Dynamic contrast-enhanced MRI (DCE-MRI) combined with tracer kinetic modelling is widely used for assessing permeability and perfusion in brain tumours and body tissues where contrast agents readily accumulate in the extracellular space. However, in diseases where leakage is subtle, the optimal approach for measuring BBB integrity is likely to differ since the magnitude and rate of enhancement caused by leakage are extremely low; several methods have been reported in the literature, yielding a wide range of parameters even in healthy subjects. We hypothesised that the Patlak model is a suitable approach for measuring low-level BBB permeability with low temporal resolution and high spatial resolution and brain coverage, and that normal levels of scanner instability would influence permeability measurements. DCE-MRI was performed in a cohort of mild stroke patients (n = 201) with a range of cerebral small vessel disease severity. We fitted these data to a set of nested tracer kinetic models, ranking their performance according to the Akaike information criterion. To assess the influence of scanner drift, we scanned 15 healthy volunteers that underwent a “sham” DCE-MRI procedure without administration of contrast agent. Numerical simulations were performed to investigate model validity and the effect of scanner drift. The Patlak model was found to be most appropriate for fitting low-permeability data, and the simulations showed vp and KTrans estimates to be reasonably robust to the model assumptions. However, signal drift (measured at approximately 0.1% per minute and comparable to literature reports in other settings) led to systematic errors in calculated tracer kinetic parameters, particularly at low permeabilities. Our findings justify the growing use of the Patlak model
Tracer kinetic modelling for DCE-MRI quantification of subtle blood-brain barrier permeability.
Heye, Anna K; Thrippleton, Michael J; Armitage, Paul A; Valdés Hernández, Maria del C; Makin, Stephen D; Glatz, Andreas; Sakka, Eleni; Wardlaw, Joanna M
2016-01-15
There is evidence that subtle breakdown of the blood-brain barrier (BBB) is a pathophysiological component of several diseases, including cerebral small vessel disease and some dementias. Dynamic contrast-enhanced MRI (DCE-MRI) combined with tracer kinetic modelling is widely used for assessing permeability and perfusion in brain tumours and body tissues where contrast agents readily accumulate in the extracellular space. However, in diseases where leakage is subtle, the optimal approach for measuring BBB integrity is likely to differ since the magnitude and rate of enhancement caused by leakage are extremely low; several methods have been reported in the literature, yielding a wide range of parameters even in healthy subjects. We hypothesised that the Patlak model is a suitable approach for measuring low-level BBB permeability with low temporal resolution and high spatial resolution and brain coverage, and that normal levels of scanner instability would influence permeability measurements. DCE-MRI was performed in a cohort of mild stroke patients (n=201) with a range of cerebral small vessel disease severity. We fitted these data to a set of nested tracer kinetic models, ranking their performance according to the Akaike information criterion. To assess the influence of scanner drift, we scanned 15 healthy volunteers that underwent a "sham" DCE-MRI procedure without administration of contrast agent. Numerical simulations were performed to investigate model validity and the effect of scanner drift. The Patlak model was found to be most appropriate for fitting low-permeability data, and the simulations showed vp and K(Trans) estimates to be reasonably robust to the model assumptions. However, signal drift (measured at approximately 0.1% per minute and comparable to literature reports in other settings) led to systematic errors in calculated tracer kinetic parameters, particularly at low permeabilities. Our findings justify the growing use of the Patlak model in low
Modeling near-barrier collisions of heavy ions based on a Langevin-type approach
Karpov, A. V.; Saiko, V. V.
2017-08-01
Background: Multinucleon transfer in low-energy nucleus-nucleus collisions is proposed as a method of production of yet-unknown neutron-rich nuclei hardly reachable by other methods. Purpose: Modeling of dynamics of nuclear reactions induced by heavy ions in their full complexity of competing reaction channels remains to be a challenging task. The work is aimed at development of such a model and its application to the analysis of multinucleon transfer in deep inelastic collisions of heavy ions leading, in particular, to formation of neutron-rich isotopes in the vicinity of the N =126 shell closure. Method: Multidimensional dynamical model of nucleus-nucleus collisions based on the Langevin equations has been proposed. It is combined with a statistical model for simulation of de-excitation of primary reaction fragments. The model provides a continuous description of the system evolution starting from the well-separated target and projectile in the entrance channel of the reaction up to the formation of final reaction products. Results: A rather complete set of experimental data available for reactions 136Xe+198Pt,208Pb,209Bi was analyzed within the developed model. The model parameters have been determined. The calculated energy, mass, charge, and angular distributions of reaction products, their various correlations as well as cross sections for production of specific isotopes agree well with the data. On this basis, optimal experimental conditions for synthesizing the neutron-rich nuclei in the vicinity of the N =126 shell were formulated and the corresponding cross sections were predicted. Conclusions: The production yields of neutron-rich nuclei with N =126 weakly depend on the incident energy. At the same time, the corresponding angular distributions are strongly energy dependent. They are peaked at grazing angles for larger energies and extend up to the forward angles at low near-barrier collision energies. The corresponding cross sections exceed 100 nb for
Membrane configuration optimization for a murine in vitro blood-brain barrier model.
Wuest, Diane M; Wing, Allison M; Lee, Kelvin H
2013-01-30
A powerful experimental tool used to study the dynamic functions of the blood-brain barrier (BBB) is an in vitro cellular based system utilizing cell culture inserts in multi-well plates. Currently, usage of divergent model configurations without explanation of selected variable set points renders data comparisons difficult and limits widespread understanding. This work presents for the first time in literature a comprehensive screening study to optimize membrane configuration, with aims to unveil influential membrane effects on the ability of cerebral endothelial cells to form a tight monolayer. First, primary murine brain endothelial cells and astrocytes were co-cultured in contact and non-contact orientations on membranes of pore diameter sizes ranging from 0.4 μm to 8.0 μm, and the non-contact orientation and smallest pore diameter size were shown to support a significantly tighter monolayer formation. Then, membranes made from polyethylene terephthalate (PET) and polycarbonate (PC) purchased from three different commercial sources were compared, and PET membranes purchased from two manufacturers facilitated a significantly tighter monolayer formation. Models were characterized by transendothelial electrical resistance (TEER), sodium fluorescein permeability, and immunocytochemical labeling of tight junction proteins. Finally, a murine brain endothelial cell line, bEnd.3, was grown on the different membranes, and similar results were obtained with respect to optimal membrane configuration selection. The results and methodology presented here on high throughput 24-well plate inserts can be translated to other BBB systems to advance model understanding. Copyright © 2012 Elsevier B.V. All rights reserved.
Hattori, Haroldo T
2014-10-10
In a parabolic mirror, light coming parallel to the antenna passes through its focal point. In this work, a waveguide feeds a semi-parabolic photonic crystal mirror and the emerging beam feeds a bow-tie antenna placed at the mirror's focal point-it is shown that the antenna system can not only feed a bow-tie antenna (producing a localized moderately high electric field) but also produces a directional radiation beam. The semi-parabolic mirror is also modified to reduce reflection back to the feeding waveguide.
Tang, Yuelong; Hua, Yuchun
2017-01-01
In this paper, a semidiscrete finite element method for solving bilinear parabolic optimal control problems is considered. Firstly, we present a finite element approximation of the model problem. Secondly, we bring in some important intermediate variables and their error estimates. Thirdly, we derive a priori error estimates of the approximation scheme. Finally, we obtain the superconvergence between the semidiscrete finite element solutions and projections of the exact solutions. A numerical example is presented to verify our theoretical results.
Coupled simulation of performance of a crossed compound parabolic concentrator with solar cell
2015-01-01
An optimal installation of a compound parabolic concentrator (CCPC) into a scalable solar thermoelectrics and photovoltaics system is desirable by applying analytical tools to improve the optical and thermal performance of a CCPC with a solar cell. In this paper, the optical and thermal performances of an isolated CCPC with solar cell are investigated by employing commercial software ‘ANSYS CFX 15.0’ with a coupled optical grey and multiphysics model. Numerical results are validated against t...
Li, Xiaomeng; Xu, Hongzhong; Chen, Jiawei; Chen, Qinghua; Zhang, Jiang; Di, Zengru
2016-09-06
Human migration is responsible for forming modern civilization and has had an important influence on the development of various countries. There are many issues worth researching, and "the reason to move" is the most basic one. The concept of migration cost in the classical self-selection theory, which was introduced by Roy and Borjas, is useful. However, migration cost cannot address global migration because of the limitations of deterministic and bilateral choice. Following the idea of migration cost, this paper developed a new probabilistic multilateral migration model by introducing the Boltzmann factor from statistical physics. After characterizing the underlying mechanism or driving force of human mobility, we reveal some interesting facts that have provided a deeper understanding of international migration, such as the negative correlation between migration costs for emigrants and immigrants and a global classification with clear regional and economic characteristics, based on clustering of migration cost vectors. In addition, we deconstruct the migration barriers using regression analysis and find that the influencing factors are complicated but can be partly (12.5%) described by several macro indexes, such as the GDP growth of the destination country, the GNI per capita and the HDI of both the source and destination countries.
Flavonoid transport across RBE4 cells: A blood-brain barrier model.
Faria, Ana; Pestana, Diogo; Teixeira, Diana; Azevedo, Joana; De Freitas, Victor; Mateus, Nuno; Calhau, Conceição
2010-06-01
There is a growing interest in dietary therapeutic strategies to combat oxidative stress-induced damage to the Central Nervous System (CNS), which is associated with a number of pathophysiological processes, including Alzheimer's and Parkinson's diseases and cerebrovascular diseases. Identifying the mechanisms associated with phenolic neuroprotection has been delayed by the lack of information concerning the ability of these compounds to enter the CNS. The aim of this study was to evaluate the transmembrane transport of flavonoids across RBE-4 cells (an immortalized cell line of rat cerebral capillary endothelial cells) and the effect of ethanol on this transport. The detection and quantification of all of the phenolic compounds in the studied samples (basolateral media) was performed using a HPLC-DAD (Diode Array Detector). All of the tested flavonoids (catechin, quercetin and cyanidin-3-glucoside) passed across the RBE-4 cells in a time-dependent manner. This transport was not influenced by the presence of 0.1% ethanol. In conclusion, the tested flavonoids were capable of crossing this blood-brain barrier model.
Modeling of dielectric barrier discharge excimer lamp excited by mono polar voltage pulses
Akashi, Haruaki; Oda, Akinori; Sakai, Yosuke
2007-10-01
Filametal discharges in Dielectric Barrier Discharge (DBD) excimer lamp excited by mono polar voltage pulses has been simulated using two dimensional fluid model. And the differences of the filament discharges formations between mono polar case and bipolar case [1] have been examined. Xe gas was used and its pressure is 300Torr. Simulated region is 1cm (gap length) x 3cm (radial length). Periodical boundary conditions are assumed for the radial direction boundaries. The both electrodes are covered with dielectrics and their thickness is 0.2cm. Applied voltage is 5kV trapezoid shape with 50% duty ratio waveform and its repetition rate is 200kpps. First a small amount of electron-ion pair is provided in the middle of the gap for initial condition. Then the voltage starts to apply. In the case of bipolar excitation, the discharge starts from one filament (streamer discharge), and finally, 5 filaments are obtained self-consistently. In the case of mono polar case, as first, similar to bipolar case, the discharge starts from one filament, however, only 3 filaments have been obtained. This result is similar to that of 100kHz bipolar voltage case. [1] H. Akashi et al, IEEE Trans. Plasma Science, Vol.33, No.2 (2005) pp.308-309
Baldus, Sabrina; Schröder, Daniel; Bibinov, Nikita; Schulz-von der Gathen, Volker; Awakowicz, Peter
2015-06-01
Cold atmospheric pressure plasmas are a promising alternative therapy for treatment of chronic wounds, as they have already shown in clinical trials. In this study an air dielectric barrier discharge (DBD) developed for therapeutic use in dermatology is characterized with respect to the plasma produced reactive oxygen species, namely atomic oxygen and ozone, which are known to be of great importance to wound healing. To understand the plasma chemistry of the applied DBD, xenon-calibrated two-photon laser-induced fluorescence spectroscopy and optical absorption spectroscopy are applied. The measured spatial distributions are shown and compared to each other. A model of the afterglow chemistry based on optical emission spectroscopy is developed to cross-check the measurement results and obtain insight into the dynamics of the considered reactive oxygen species. The atomic oxygen density is found to be located mostly between the electrodes with a maximum density of {{n}\\text{O}}=6× {{10}16} cm-3 . Time resolved measurements reveal a constant atomic oxygen density between two high voltage pulses. The ozone is measured up to 3 mm outside the active plasma volume, reaching a maximum value of {{n}{{\\text{O}3}}}=3× {{10}16} cm-3 between the electrodes.
Ali Abdul-Aziz
2014-01-01
Full Text Available The necessity for a protecting guard for the popular ceramic matrix composites (CMCs is getting a lot of attention from engine manufacturers and aerospace companies. The CMC has a weight advantage over standard metallic materials and more performance benefits. However, these materials undergo degradation that typically includes coating interface oxidation as opposed to moisture induced matrix which is generally seen at a higher temperature. Additionally, other factors such as residual stresses, coating process related flaws, and casting conditions may influence the degradation of their mechanical properties. These durability considerations are being addressed by introducing highly specialized form of environmental barrier coating (EBC that is being developed and explored in particular for high temperature applications greater than 1100°C. As a result, a novel computational simulation approach is presented to predict life for EBC/CMC specimen using the finite element method augmented with progressive failure analysis (PFA that included durability, damage tracking, and material degradation model. The life assessment is carried out using both micromechanics and macromechanics properties. The macromechanics properties yielded a more conservative life for the CMC specimen as compared to that obtained from the micromechanics with fiber and matrix properties as input.
Fluid model for a partially packed dielectric barrier discharge plasma reactor
Gadkari, Siddharth; Tu, Xin; Gu, Sai
2017-09-01
In this work, a two-dimensional numerical fluid model is developed for a partially packed dielectric barrier discharge (DBD) in pure helium. Influence of packing on the discharge characteristics is studied by comparing the results of DBD with partial packing with those obtained for DBD with no packing. In the axial partial packing configuration studied in this work, the electric field strength was shown to be enhanced at the top surface of the spherical packing material and at the contact points between the packing and the dielectric layer. For each value of applied potential, DBD with partial packing showed an increase in the number of pulses in the current profile in the positive half cycle of the applied voltage, as compared to DBD with no packing. Addition of partial packing to the plasma-alone DBD also led to an increase in the electron and ion number densities at the moment of breakdown. The time averaged electron energy profiles showed that a much higher range of electron energy can be achieved with the use of partial packing as compared to no packing in a DBD, at the same applied power. The spatially and time averaged values over one voltage cycle also showed an increase in power density and electron energy on inclusion of partial packing in the DBD. For the applied voltage parameters studied in this work, the discharge was found to be consistently homogeneous and showed the characteristics of atmospheric pressure glow discharge.
Li, Xiaomeng; Xu, Hongzhong; Chen, Jiawei; Chen, Qinghua; Zhang, Jiang; di, Zengru
2016-09-01
Human migration is responsible for forming modern civilization and has had an important influence on the development of various countries. There are many issues worth researching, and “the reason to move” is the most basic one. The concept of migration cost in the classical self-selection theory, which was introduced by Roy and Borjas, is useful. However, migration cost cannot address global migration because of the limitations of deterministic and bilateral choice. Following the idea of migration cost, this paper developed a new probabilistic multilateral migration model by introducing the Boltzmann factor from statistical physics. After characterizing the underlying mechanism or driving force of human mobility, we reveal some interesting facts that have provided a deeper understanding of international migration, such as the negative correlation between migration costs for emigrants and immigrants and a global classification with clear regional and economic characteristics, based on clustering of migration cost vectors. In addition, we deconstruct the migration barriers using regression analysis and find that the influencing factors are complicated but can be partly (12.5%) described by several macro indexes, such as the GDP growth of the destination country, the GNI per capita and the HDI of both the source and destination countries.
Li, Xiaomeng; Xu, Hongzhong; Chen, Jiawei; Chen, Qinghua; Zhang, Jiang; Di, Zengru
2016-01-01
Human migration is responsible for forming modern civilization and has had an important influence on the development of various countries. There are many issues worth researching, and “the reason to move” is the most basic one. The concept of migration cost in the classical self-selection theory, which was introduced by Roy and Borjas, is useful. However, migration cost cannot address global migration because of the limitations of deterministic and bilateral choice. Following the idea of migration cost, this paper developed a new probabilistic multilateral migration model by introducing the Boltzmann factor from statistical physics. After characterizing the underlying mechanism or driving force of human mobility, we reveal some interesting facts that have provided a deeper understanding of international migration, such as the negative correlation between migration costs for emigrants and immigrants and a global classification with clear regional and economic characteristics, based on clustering of migration cost vectors. In addition, we deconstruct the migration barriers using regression analysis and find that the influencing factors are complicated but can be partly (12.5%) described by several macro indexes, such as the GDP growth of the destination country, the GNI per capita and the HDI of both the source and destination countries. PMID:27597319
Nanoparticulate transport of oximes over an in vitro blood-brain barrier model.
Sylvia Wagner
Full Text Available BACKGROUND: Due to the use of organophosphates (OP as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem. The acute toxicity of an OP poisoning is mainly due to the inhibition of acetylcholinesterase (AChE in the peripheral and central nervous systems (CNS. This results in an increase in the synaptic concentration of the neurotransmitter acetylcholine, overstimulation of cholinergic receptors and disorder of numerous body functions up to death. The standard treatment of OP poisoning includes a combination of a muscarinic antagonist and an AChE reactivator (oxime. However, these oximes can not cross the blood-brain barrier (BBB sufficiently. Therefore, new strategies are needed to transport oximes over the BBB. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we combined different oximes (obidoxime dichloride and two different HI 6 salts, HI 6 dichloride monohydrate and HI 6 dimethanesulfonate with human serum albumin nanoparticles and could show an oxime transport over an in vitro BBB model. In general, the nanoparticulate transported oximes achieved a better reactivation of OP-inhibited AChE than free oximes. CONCLUSIONS/SIGNIFICANCE: With these nanoparticles, for the first time, a tool exists that could enable a transport of oximes over the BBB. This is very important for survival after severe OP intoxication. Therefore, these nanoparticulate formulations are promising formulations for the treatment of the peripheral and the CNS after OP poisoning.
Mid-gap phenomena in chalcogenide glasses and barrier-cluster-heating model
Banik, Ivan, E-mail: ivan.banik@stuba.sk; Kubliha, Marián; Lukovičová, Jozefa; Pavlendová, Gabriela [Faculty of Civil Engineering, Slovak University of Technology, 813 68 Bratislava (Slovakia)
2015-12-07
The physical mechanism of photoluminescence spectrum formation of chalcogenide glasses (CHG) belongs to the important unsolved problems in physics of non-crystalline materials. Photoluminescence is an important means of the electron spectrum investigation. PL spectrum in CHG is produced mostly in the middle of the band gap, and its profile is normal - Gaussian. Several features of PL spectra in CHG is still a great mystery. The aim of the paper is to make reader acquainted with the new insight into the problem. In this article we also deal with the issue of clarifying the nature of mid-gap absorption. From the experiments it is known that after excitation of the glass As{sub 2}S{sub 3} (or As{sub 2}Se{sub 3}) with primary radiation from Urbach-tail region the glass will be able to absorb the photons of low energy (IR) radiation from mid-gap region of spectra. This low photon absorption without action of the primary excitation radiation of the higher photon energy is impossible. Mid-gap absorption yields boost in the photoluminescence. The paper gives the reader the new insights into some, until now, unexplained effects and contexts in chalcogenide glasses from the position of barrier-cluster-heating model.
Crossing the blood-brain-barrier with transferrin conjugated carbon dots: A zebrafish model study.
Li, Shanghao; Peng, Zhili; Dallman, Julia; Baker, James; Othman, Abdelhameed M; Blackwelder, Patrica L; Leblanc, Roger M
2016-09-01
Drug delivery to the central nervous system (CNS) in biological systems remains a major medical challenge due to the tight junctions between endothelial cells known as the blood-brain-barrier (BBB). Here we use a zebrafish model to explore the possibility of using transferrin-conjugated carbon dots (C-Dots) to ferry compounds across the BBB. C-Dots have previously been reported to inhibit protein fibrillation, and they are also used to deliver drugs for disease treatment. In terms of the potential medical application of C-Dots for the treatment of CNS diseases, one of the most formidable challenges is how to deliver them inside the CNS. To achieve this in this study, human transferrin was covalently conjugated to C-Dots. The conjugates were then injected into the vasculature of zebrafish to examine the possibility of crossing the BBB in vivo via transferrin receptor-mediated endocytosis. The experimental observations suggest that the transferrin-C-Dots can enter the CNS while C-Dots alone cannot.
Garbuzova-Davis, Svitlana; Rodrigues, Maria C. O.; Hernandez-Ontiveros, Diana G.; Tajiri, Naoki; Frisina-Deyo, Aric; Boffeli, Sean M.; Abraham, Jerry V.; Pabon, Mibel; Wagner, Andrew; Ishikawa, Hiroto; Shinozuka, Kazutaka; Haller, Edward; Sanberg, Paul R.; Kaneko, Yuji; Borlongan, Cesario V.
2013-01-01
Background Comprehensive stroke studies reveal diaschisis, a loss of function due to pathological deficits in brain areas remote from initial ischemic lesion. However, blood-brain barrier (BBB) competence in subacute diaschisis is uncertain. The present study investigated subacute diaschisis in a focal ischemic stroke rat model. Specific focuses were BBB integrity and related pathogenic processes in contralateral brain areas. Methodology/Principal Findings In ipsilateral hemisphere 7 days after transient middle cerebral artery occlusion (tMCAO), significant BBB alterations characterized by large Evans Blue (EB) parenchymal extravasation, autophagosome accumulation, increased reactive astrocytes and activated microglia, demyelinization, and neuronal damage were detected in the striatum, motor and somatosensory cortices. Vascular damage identified by ultrastuctural and immunohistochemical analyses also occurred in the contralateral hemisphere. In contralateral striatum and motor cortex, major ultrastructural BBB changes included: swollen and vacuolated endothelial cells containing numerous autophagosomes, pericyte degeneration, and perivascular edema. Additionally, prominent EB extravasation, increased endothelial autophagosome formation, rampant astrogliosis, activated microglia, widespread neuronal pyknosis and decreased myelin were observed in contralateral striatum, and motor and somatosensory cortices. Conclusions/Significance These results demonstrate focal ischemic stroke-induced pathological disturbances in ipsilateral, as well as in contralateral brain areas, which were shown to be closely associated with BBB breakdown in remote brain microvessels and endothelial autophagosome accumulation. This microvascular damage in subacute phase likely revealed ischemic diaschisis and should be considered in development of treatment strategies for stroke. PMID:23675488
Svitlana Garbuzova-Davis
Full Text Available BACKGROUND: Comprehensive stroke studies reveal diaschisis, a loss of function due to pathological deficits in brain areas remote from initial ischemic lesion. However, blood-brain barrier (BBB competence in subacute diaschisis is uncertain. The present study investigated subacute diaschisis in a focal ischemic stroke rat model. Specific focuses were BBB integrity and related pathogenic processes in contralateral brain areas. METHODOLOGY/PRINCIPAL FINDINGS: In ipsilateral hemisphere 7 days after transient middle cerebral artery occlusion (tMCAO, significant BBB alterations characterized by large Evans Blue (EB parenchymal extravasation, autophagosome accumulation, increased reactive astrocytes and activated microglia, demyelinization, and neuronal damage were detected in the striatum, motor and somatosensory cortices. Vascular damage identified by ultrastuctural and immunohistochemical analyses also occurred in the contralateral hemisphere. In contralateral striatum and motor cortex, major ultrastructural BBB changes included: swollen and vacuolated endothelial cells containing numerous autophagosomes, pericyte degeneration, and perivascular edema. Additionally, prominent EB extravasation, increased endothelial autophagosome formation, rampant astrogliosis, activated microglia, widespread neuronal pyknosis and decreased myelin were observed in contralateral striatum, and motor and somatosensory cortices. CONCLUSIONS/SIGNIFICANCE: These results demonstrate focal ischemic stroke-induced pathological disturbances in ipsilateral, as well as in contralateral brain areas, which were shown to be closely associated with BBB breakdown in remote brain microvessels and endothelial autophagosome accumulation. This microvascular damage in subacute phase likely revealed ischemic diaschisis and should be considered in development of treatment strategies for stroke.
Nonlocal operators, parabolic-type equations, and ultrametric random walks
Chacón-Cortes, L. F., E-mail: fchaconc@math.cinvestav.edu.mx; Zúñiga-Galindo, W. A., E-mail: wazuniga@math.cinvestav.edu.mx [Centro de Investigacion y de Estudios Avanzados del I.P.N., Departamento de Matematicas, Av. Instituto Politecnico Nacional 2508, Col. San Pedro Zacatenco, Mexico D.F., C.P. 07360 (Mexico)
2013-11-15
In this article, we introduce a new type of nonlocal operators and study the Cauchy problem for certain parabolic-type pseudodifferential equations naturally associated to these operators. Some of these equations are the p-adic master equations of certain models of complex systems introduced by Avetisov, V. A. and Bikulov, A. Kh., “On the ultrametricity of the fluctuation dynamicmobility of protein molecules,” Proc. Steklov Inst. Math. 265(1), 75–81 (2009) [Tr. Mat. Inst. Steklova 265, 82–89 (2009) (Izbrannye Voprosy Matematicheskoy Fiziki i p-adicheskogo Analiza) (in Russian)]; Avetisov, V. A., Bikulov, A. Kh., and Zubarev, A. P., “First passage time distribution and the number of returns for ultrametric random walks,” J. Phys. A 42(8), 085003 (2009); Avetisov, V. A., Bikulov, A. Kh., and Osipov, V. A., “p-adic models of ultrametric diffusion in the conformational dynamics of macromolecules,” Proc. Steklov Inst. Math. 245(2), 48–57 (2004) [Tr. Mat. Inst. Steklova 245, 55–64 (2004) (Izbrannye Voprosy Matematicheskoy Fiziki i p-adicheskogo Analiza) (in Russian)]; Avetisov, V. A., Bikulov, A. Kh., and Osipov, V. A., “p-adic description of characteristic relaxation in complex systems,” J. Phys. A 36(15), 4239–4246 (2003); Avetisov, V. A., Bikulov, A. H., Kozyrev, S. V., and Osipov, V. A., “p-adic models of ultrametric diffusion constrained by hierarchical energy landscapes,” J. Phys. A 35(2), 177–189 (2002); Avetisov, V. A., Bikulov, A. Kh., and Kozyrev, S. V., “Description of logarithmic relaxation by a model of a hierarchical random walk,” Dokl. Akad. Nauk 368(2), 164–167 (1999) (in Russian). The fundamental solutions of these parabolic-type equations are transition functions of random walks on the n-dimensional vector space over the field of p-adic numbers. We study some properties of these random walks, including the first passage time.
Pseudo almost periodic solutions to parabolic boundary value inverse problems
2008-01-01
We first define the pseudo almost periodic functions in a more general setting.Then we show the existence,uniqueness and stability of pseudo almost periodic solutions of parabolic inverse problems for a type of boundary value problems.
OSCILLATION OF NONLINEAR IMPULSIVE PARABOLIC DIFFERENTIAL EQUATIONS WITH SEVERAL DELAYS
CuiChenpei; ZouMin; LiuAnping; XiaoLi
2005-01-01
In this paper, oscillatory properties for solutions of certain nonlinear impulsive parabolic equations with several delays are investigated and a series of new sufficient conditions for oscillations of the equation are established.
A Note about Parabolic Systems and Analytic Semigroups
STR?HMER Gerhard
2011-01-01
We investigate the question whether certain parabolic systems in the sense of Petrovskii fulfill the resolvent estimate required for the generation of an analytic semigroup and apply the result to a problem concerning the diffusion of gases.
A SINGLE STEP SCHEME WITH HIGH ACCURACY FOR PARABOLIC PROBLEM
陈传淼; 胡志刚
2001-01-01
A single step scheme with high accuracy for solving parabolic problem is proposed. It is shown that this scheme possesses good stability and fourth order accuracy with respect to both time and space variables, which are superconvergent.
Parabolic Equations in Musielak-Orlicz-Sobolev Spaces
M.L. Ahmed Oubeid
2013-11-01
Full Text Available We prove in this paper the existence of solutions of nonlinear parabolic problems in Musielak-Orlicz-Sobolev spaces. An approximation and a trace results in inhomogeneous Musielak-Orlicz-Sobolev spaces have also been provided.
HYPERBOLIC-PARABOLIC CHEMOTAXIS SYSTEM WITH NONLINEAR PRODUCT TERMS
Chen Hua; Wu Shaohua
2008-01-01
We prove the local existence and uniqueness of week solution of the hyperbolic-parabolic Chemotaxis system with some nonlinear product terms. For one dimensional case, we prove also the global existence and uniqueness of the solution for the problem.
An X-band parabolic antenna based on gradient metasurface
Yao, Wang; Yang, Helin, E-mail: emyang@mail.ccnu.edu.cn; Tian, Ying; Guo, Linyan [College of Physical Science and Technology, Central China Normal University, Wuhan 430079 (China); Huang, Xiaojun [College of Physical Science and Technology, Central China Normal University, Wuhan 430079 (China); College of physics and electrical engineering, Kashgar University, Kashgar, 844000 (China)
2016-07-15
We present a novel parabolic antenna by employing reflection gradient metasurface which is composed of a series of circle patches on a grounded dielectric substrate. Similar to the traditional parabolic antenna, the proposed antenna take the metasurface as a “parabolic reflector” and a patch antenna was placed at the focal point of the metasurface as a feed source, then the quasi-spherical wave emitted by the source is reflected and transformed to plane wave with high efficiency. Due to the focus effect of reflection, the beam width of the antenna has been decreased from 85.9° to 13° and the gain has been increased from 6.5 dB to 20.8 dB. Simulation and measurement results of both near and far-field plots demonstrate good focusing properties of the proposed parabolic antenna.
On Doubly Degenerate Quasilinear Parabolic Equations of Higher Order
Zhen Hai LIU
2005-01-01
We deal with the existence of periodic solutions for doubly degenerate quasilinear parabolic equations of higher order, which can degenerate, on a part of the boundary, on a segment in the interior of the domain and in time.
Homogenization of attractors for a class of nonlinear parabolic equations
WANG Guo-lian; ZHANG Xing-you
2004-01-01
The relation between the global attractors Aε for a calss of quasilinear parabolic equations and the global attractor A0for the homogenized equation is discussed, and an explicit error estimate between Aε and A0 is given.
The homogenization of a class of degenerate quasilinear parabolic equations
ZHANG Xingyou; HUANG Yong
2003-01-01
The homogenization of a class of degenerate quasilinear parabolic equations is studied. The Ap weight theory and the classical compensated compactness method are incorporated to obtain the homogenized equation.
IDENTIFICATION OF PARAMETERS IN PARABOLIC EQUATIONS WITH NONLINEARITY
无
2010-01-01
In this paper, we consider the identification of parameters in parabolic equations with nonlinearity. Some approximation processes for the identification problem are given. Our results improve and generalize the previous results.
Classification of conformal representations induced from the maximal cuspidal parabolic
Dobrev, V. K., E-mail: dobrev@inrne.bas.bg [Scuola Internazionale Superiore di Studi Avanzati (Italy)
2017-03-15
In the present paper we continue the project of systematic construction of invariant differential operators on the example of representations of the conformal algebra induced from the maximal cuspidal parabolic.
Differentiability at lateral boundary for fully nonlinear parabolic equations
Ma, Feiyao; Moreira, Diego R.; Wang, Lihe
2017-09-01
For fully nonlinear uniformly parabolic equations, the first derivatives regularity of viscosity solutions at lateral boundary is studied under new Dini type conditions for the boundary, which is called Reifenberg Dini conditions and is weaker than usual Dini conditions.
FASTRACK (TM): Parabolic and Suborbital Experiment Support Facility
Richards, Stephanie E. (Compiler); Levine, Howard G.; Romero, V.
2016-01-01
FASTRACK was developed by NASA Kennedy Space Center and Space Florida to provide capabilities to conduct frequent, affordable, and responsive flight opportunities for reduced gravity experiments, technology development, and hardware testing on suborbital vehicles and parabolic flights.
Quasiconformal mappings and degenerate elliptic and parabolic equations
Filippo Chiarenza
1987-11-01
Full Text Available In this paper two Harnak inequalities are proved concerning a degenerate elliptic and a degenerate parabolic equation. In both cases the weight giving the degeneracy is a power of the jacobian of a quasiconformal mapping.
Modeling and Simulation of Long-Term Performance of Near-Surface Barriers
Piet, S. J.; Jacobson, J. J.; Martian, P.; Martineau, R.; Soto, R.
2003-02-25
Society has and will continue to generate hazardous wastes whose risks must be managed. For exceptionally toxic, long-lived, and feared waste, the solution is deep burial, e.g., deep geological disposal at Yucca Mtn. For some waste, recycle or destruction/treatment is possible. The alternative for other wastes is storage at or near the ground level (in someone's back yard); most of these storage sites include a surface barrier (cap) to prevent migration of the waste due to infiltration of surface water. The design lifespan for such barriers ranges from 30 to 1000 years, depending on hazard and regulations. In light of historical performance, society needs a better basis for predicting barrier performance over long time periods and tools for optimizing maintenance of barriers while in service. We believe that, as in other industries, better understanding of the dynamics of barrier system degradation will enable improved barriers (cheaper, longer-lived, simpler, easier to maintain) and improved maintenance. We are focusing our research on earthen caps, especially those with evapo-transpiration and capillary breaks. Typical cap assessments treat the barrier's structure as static prior to some defined lifetime. Environmental boundary conditions such as precipitation and temperature are treated as time dependent. However, other key elements of the barrier system are regarded as constant, including engineered inputs (e.g., fire management strategy, irrigation, vegetation control), surface ecology (critical to assessment of plant transpiration), capillary break interface, material properties, surface erosion rate, etc. Further, to be conservative, only harmful processes are typically considered. A more holistic examination of both harmful and beneficial processes will provide more realistic pre-service prediction and in-service assessment of performance as well as provide designers a tool to encourage beneficial processes while discouraging harmful processes
Helms, Hans C; Abbott, N Joan; Burek, Malgorzata; Cecchelli, Romeo; Couraud, Pierre-Olivier; Deli, Maria A; Förster, Carola; Galla, Hans J; Romero, Ignacio A; Shusta, Eric V; Stebbins, Matthew J; Vandenhaute, Elodie; Weksler, Babette; Brodin, Birger
2016-05-01
The endothelial cells lining the brain capillaries separate the blood from the brain parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial interface for exchange of nutrients, gases, and metabolites between blood and brain, and as a barrier for neurotoxic components of plasma and xenobiotics. This "blood-brain barrier" function is a major hindrance for drug uptake into the brain parenchyma. Cell culture models, based on either primary cells or immortalized brain endothelial cell lines, have been developed, in order to facilitate in vitro studies of drug transport to the brain and studies of endothelial cell biology and pathophysiology. In this review, we aim to give an overview of established in vitro blood-brain barrier models with a focus on their validation regarding a set of well-established blood-brain barrier characteristics. As an ideal cell culture model of the blood-brain barrier is yet to be developed, we also aim to give an overview of the advantages and drawbacks of the different models described. © The Author(s) 2016.
Walters, David; Moore, Laura J.; Duran Vinent, Orencio; Fagherazzi, Sergio; Mariotti, Giulio
2014-09-01
Interactions between backbarrier marshes and barrier islands will likely play an important role in determining how low-lying coastal systems respond to sea level rise and changes in storminess in the future. To assess the role of couplings between marshes and barrier islands under changing conditions, we develop and apply a coupled barrier island-marsh model (GEOMBEST+) to assess the impact of overwash deposition on backbarrier marsh morphology and of marsh morphology on rates of island migration. Our model results suggest that backbarrier marsh width is in a constant state of change until either the backbarrier basin becomes completely filled or backbarrier marsh deposits have completely eroded away. Results also suggest that overwash deposition is an important source of sediment, which allows existing narrow marshes to be maintained in a long-lasting alternate state (~500 m wide in the Virginia Barrier Islands) within a range of conditions under which they would otherwise disappear. The existence of a narrow marsh state is supported by observations of backbarrier marshes along the eastern shore of Virginia. Additional results suggest that marshes reduce accommodation in the backbarrier bay, which, in turn, decreases island migration rate. As climate change results in sea level rise, and the increased potential for intense hurricanes resulting in overwash, it is likely that these couplings will become increasingly important in determining future system behavior.
Flux form Semi-Lagrangian methods for parabolic problems
Bonaventura Luca
2016-09-01
Full Text Available A semi-Lagrangian method for parabolic problems is proposed, that extends previous work by the authors to achieve a fully conservative, flux-form discretization of linear and nonlinear diffusion equations. A basic consistency and stability analysis is proposed. Numerical examples validate the proposed method and display its potential for consistent semi-Lagrangian discretization of advection diffusion and nonlinear parabolic problems.
MAXIMUM PRINCIPLES FOR SECOND-ORDER PARABOLIC EQUATIONS
Antonio Vitolo
2004-01-01
This paper is the parabolic counterpart of previous ones about elliptic operators in unbounded domains. Maximum principles for second-order linear parabolic equations are established showing a variant of the ABP-Krylov-Tso estimate, based lower bound for super-solutions due to Krylov and Safonov. The results imply the uniqueness for the Cauchy-Dirichlet problem in a large class of infinite cylindrical and non-cylindrical domains.
The parabolic trigonometric functions and the Chebyshev radicals
Dattoli, G.; Migliorati, M.; Ricci, P. E.
2011-01-01
The parabolic trigonometric functions have recently been introduced as an intermediate step between circular and hyperbolic functions. They have been shown to be expressible in terms of irrational functions, linked to the solution of third degree algebraic equations. We show the link of the parabolic trigonometric functions with the Chebyshev radicals and also prove that further generalized forms of trigonometric functions, providing the natural solutions of the quintic algebraic equation, ca...
Comparison principle for parabolic equations in the Heisenberg group
Thomas Bieske
2005-09-01
Full Text Available We define two notions of viscosity solutions to parabolic equations in the Heisenberg group, depending on whether the test functions concern only the past or both the past and the future. We then exploit the Heisenberg geometry to prove a comparison principle for a class of parabolic equations and show the sufficiency of considering the test functions that concern only the past.
Null controllability for a parabolic-elliptic coupled system
Fernández-Cara, E; de Menezes, S B
2012-01-01
In this paper, we prove the null controllability of some parabolic-elliptic systems. The control is distributed, locally supported in space and appears only in one PDE. The arguments rely on fixed-point reformulation and suitable Carleman estimates for the solutions to the adjoint system. Under appropriate assumptions, we also prove that the solution can be obtained as the asymptotic limit of some similar parabolic systems.
Three-dimensional nonparaxial beams in parabolic rotational coordinates.
Deng, Dongmei; Gao, Yuanmei; Zhao, Juanying; Zhang, Peng; Chen, Zhigang
2013-10-01
We introduce a class of three-dimensional nonparaxial optical beams found in a parabolic rotational coordinate system. These beams, representing exact solutions of the nonparaxial Helmholtz equation, have inherent parabolic symmetries. Assisted with a computer-generated holography, we experimentally demonstrate the generation of different modes of these beams. The observed transverse beam patterns along the propagation direction agree well with those from our theoretical predication.
shiva madahian
2017-01-01
Full Text Available Background and goal: The interaction between university and industry, due to its highly constructive and positive effects on technical, economic and social changes, was traditionally at the center of policy makers’ and planners’ attention. The aim of the present study was to explain barriers and challenges existing in the interaction between medical sciences universities and industry. Method: This present descriptive-correlational study used measuring method fto investigate the interaction among Medical Sciences University (School of Public Health. 1468 individuals participated in this study. Using Morgan scale, 321 people were selected as the sample. Two questionnaires were prepared by the researcher. The proper governance questionnaire contains political, economic, social, legal and cultural dimensions composed of 69 questions. The barriers between university and industry questionnaire covering 3 dimensions of individual interaction barriers, organizational interaction barriers and environmental interaction barriers is composed of 40 questions. Data analysis was done using SPSS, version 21. Results: Based on factor analysis of the data, the main dimension of proper governance respectively was cultural factors and among various factors of barriers between university and industry, environmental interaction dimension was considered as the most important one. Moreover, the results showed that there was a direct and meaningful relationship between dimensions of proper governance and interaction between university and industry variable. Conclusion: Based on the results of the present study, considering culture and cultural differences can help improve the interaction between university and industry.
Neuhaus, Winfried; Samwer, Fabian; Kunzmann, Steffen; Muellenbach, Ralf M; Wirth, Michael; Speer, Christian P; Roewer, Norbert; Förster, Carola Y
2012-11-01
The blood-air barrier in the lung consists of the alveolar epithelium, the underlying capillary endothelium, their basement membranes and the interstitial space between the cell layers. Little is known about the interactions between the alveolar and the blood compartment. The aim of the present study was to gain first insights into the possible interplay between these two neighbored cell layers. We established an in vitro Transwell model of the alveolar epithelium based on human cell line H441 and investigated the influence of conditioned medium obtained from human lung endothelial cell line HPMEC-ST1.6R on the barrier properties of the H441 layers. As control for tissue specificity H441 layers were exposed to conditioned medium from human brain endothelial cell line hCMEC/D3. Addition of dexamethasone was necessary to obtain stable H441 cell layers. Moreover, dexamethasone increased expression of cell type I markers (caveolin-1, RAGE) and cell type II marker SP-B, whereas decreased the transepithelial electrical resistance (TEER) in a concentration dependent manner. Soluble factors obtained from the lung endothelial cell line increased the barrier significantly proven by TEER values and fluorescein permeability on the functional level and by the differential expression of tight junctional proteins on the molecular level. In contrast to this, soluble factors derived from brain endothelial cells weakened the barrier significantly. In conclusion, soluble factors from lung endothelial cells can strengthen the alveolar epithelium barrier in vitro, which suggests communication between endothelial and epithelial cells regulating the integrity of the blood-air barrier.
Drivers of coupled model ENSO error dynamics and the spring predictability barrier
Larson, Sarah M.; Kirtman, Ben P.
2017-06-01
Despite recent improvements in ENSO simulations, ENSO predictions ultimately remain limited by error growth and model inadequacies. Determining the accompanying dynamical processes that drive the growth of certain types of errors may help the community better recognize which error sources provide an intrinsic limit to predictability. This study applies a dynamical analysis to previously developed CCSM4 error ensemble experiments that have been used to model noise-driven error growth. Analysis reveals that ENSO-independent error growth is instigated via a coupled instability mechanism. Daily error fields indicate that persistent stochastic zonal wind stress perturbations (τx^' } ) near the equatorial dateline activate the coupled instability, first driving local SST and anomalous zonal current changes that then induce upwelling anomalies and a clear thermocline response. In particular, March presents a window of opportunity for stochastic τx^' } to impose a lasting influence on the evolution of eastern Pacific SST through December, suggesting that stochastic τx^' } is an important contributor to the spring predictability barrier. Stochastic winds occurring in other months only temporarily affect eastern Pacific SST for 2-3 months. Comparison of a control simulation with an ENSO cycle and the ENSO-independent error ensemble experiments reveals that once the instability is initiated, the subsequent error growth is modulated via an ENSO-like mechanism, namely the seasonal strength of the Bjerknes feedback. Furthermore, unlike ENSO events that exhibit growth through the fall, the growth of ENSO-independent SST errors terminates once the seasonal strength of the Bjerknes feedback weakens in fall. Results imply that the heat content supplied by the subsurface precursor preceding the onset of an ENSO event is paramount to maintaining the growth of the instability (or event) through fall.
Drivers of coupled model ENSO error dynamics and the spring predictability barrier
Larson, Sarah M.; Kirtman, Ben P.
2016-07-01
Despite recent improvements in ENSO simulations, ENSO predictions ultimately remain limited by error growth and model inadequacies. Determining the accompanying dynamical processes that drive the growth of certain types of errors may help the community better recognize which error sources provide an intrinsic limit to predictability. This study applies a dynamical analysis to previously developed CCSM4 error ensemble experiments that have been used to model noise-driven error growth. Analysis reveals that ENSO-independent error growth is instigated via a coupled instability mechanism. Daily error fields indicate that persistent stochastic zonal wind stress perturbations (τx^' } ) near the equatorial dateline activate the coupled instability, first driving local SST and anomalous zonal current changes that then induce upwelling anomalies and a clear thermocline response. In particular, March presents a window of opportunity for stochastic τx^' } to impose a lasting influence on the evolution of eastern Pacific SST through December, suggesting that stochastic τx^' } is an important contributor to the spring predictability barrier. Stochastic winds occurring in other months only temporarily affect eastern Pacific SST for 2-3 months. Comparison of a control simulation with an ENSO cycle and the ENSO-independent error ensemble experiments reveals that once the instability is initiated, the subsequent error growth is modulated via an ENSO-like mechanism, namely the seasonal strength of the Bjerknes feedback. Furthermore, unlike ENSO events that exhibit growth through the fall, the growth of ENSO-independent SST errors terminates once the seasonal strength of the Bjerknes feedback weakens in fall. Results imply that the heat content supplied by the subsurface precursor preceding the onset of an ENSO event is paramount to maintaining the growth of the instability (or event) through fall.
Fabrication and characterization of non-linear parabolic microporous membranes.
Rajasekaran, Pradeep Ramiah; Sharifi, Payam; Wolff, Justin; Kohli, Punit
2015-01-01
Large scale fabrication of non-linear microporous membranes is of technological importance in many applications ranging from separation to microfluidics. However, their fabrication using traditional techniques is limited in scope. We report on fabrication and characterization of non-linear parabolic micropores (PMS) in polymer membranes by utilizing flow properties of fluids. The shape of the fabricated PMS corroborated well with simplified Navier-Stokes equation describing parabolic relationship of the form L - t(1/2). Here, L is a measure of the diameter of the fabricated micropores during flow time (t). The surface of PMS is smooth due to fluid surface tension at fluid-air interface. We demonstrate fabrication of PMS using curable polydimethylsiloxane (PDMS). The parabolic shape of micropores was a result of interplay between horizontal and vertical fluid movements due to capillary, viscoelastic, and gravitational forces. We also demonstrate fabrication of asymmetric "off-centered PMS" and an array of PMS membranes using this simple fabrication technique. PMS containing membranes with nanoscale dimensions are also possible by controlling the experimental conditions. The present method provides a simple, easy to adopt, and energy efficient way for fabricating non-linear parabolic shape pores at microscale. The prepared parabolic membranes may find applications in many areas including separation, parabolic optics, micro-nozzles / -valves / -pumps, and microfluidic and microelectronic delivery systems.
Roig, Francesc; Saigí, Francesc
2011-01-01
Despite the clear political will to promote telemedicine and the large number of initiatives, the incorporation of this modality in clinical practice remains limited. The objective of this study was to identify the barriers perceived by key professionals who actively participate in the design and implementation of telemedicine in a healthcare system model based on purchasing of healthcare services using providers' contracts. We performed a qualitative study based on data from semi-structured interviews with 17 key informants belonging to distinct Catalan health organizations. The barriers identified were grouped in four areas: technological, organizational, human and economic. The main barriers identified were changes in the healthcare model caused by telemedicine, problems with strategic alignment, resistance to change in the (re)definition of roles, responsibilities and new skills, and lack of a business model that incorporates telemedicine in the services portfolio to ensure its sustainability. In addition to suitable management of change and of the necessary strategic alignment, the definitive normalization of telemedicine in a mixed healthcare model based on purchasing of healthcare services using providers' contracts requires a clear and stable business model that incorporates this modality in the services portfolio and allows healthcare organizations to obtain reimbursement from the payer. 2010 SESPAS. Published by Elsevier Espana. All rights reserved.
Freese, Christian; Hanada, Sanshiro; Fallier-Becker, Petra; Kirkpatrick, C James; Unger, Ronald E
2017-05-01
We previously demonstrated that the co-cultivation of endothelial cells with neural cells resulted in an improved integrity of the in vitro blood-brain barrier (BBB), and that this model could be useful to evaluate the transport properties of potential central nervous system disease drugs through the microvascular brain endothelial. In this study we have used real-time PCR, fluorescent microscopy, protein arrays and enzyme-linked immunosorbent assays to determine which neural- and endothelial cell-derived factors are produced in the co-culture and improve the integrity of the BBB. In addition, a further improvement of the BBB integrity was achieved by adjusting serum concentrations and growth factors or by the addition of brain pericytes. Under specific conditions expression of angiogenic, angiostatic and neurotrophic factors such as endostatin, pigment epithelium derived factor (PEDF/serpins-F1), tissue inhibitor of metalloproteinases (TIMP-1), and vascular endothelial cell growth factor (VEGF) closely mimicked the in vivo situation. Freeze-fracture analysis of these cultures demonstrated the quality and organization of the endothelial tight junction structures and their association to the two different lipidic leaflets of the membrane. Finally, a multi-cell culture model of the BBB with a transendothelial electrical resistance up to 371 (±15) Ω×cm(2) was developed, which may be useful for preliminary screening of drug transport across the BBB and to evaluate cellular crosstalk of cells involved in the neurovascular unit.
Modeling and Simulation of Long-Term Performance of Near-Surface Barriers
Piet, Steven James; Jacobson, Jacob Jordan; Soto, Rafael; Martian, Pete; Martineau, Richard Charles
2003-02-01
Society has and will continue to generate hazardous wastes whose risks must be managed. For exceptionally toxic, long-lived, and feared waste, the solution is deep burial, e.g., deep geological disposal at Yucca Mtn. For some waste, recycle or destruction/treatment is possible. The alternative for other wastes is storage at or near the ground level (in someone’s back yard); most of these storage sites include a surface barrier (cap) to prevent migration of the waste due to infiltration of surface water. The design lifespan for such barriers ranges from 30 to 1000 years, depending on hazard and regulations. In light of historical performance, society needs a better basis for predicting barrier performance over long time periods and tools for optimizing maintenance of barriers while in service. We believe that, as in other industries, better understanding of the dynamics of barrier system degradation will enable improved barriers (cheaper, longer-lived, simpler, easier to maintain) and improved maintenance. We are focusing our research on earthen caps, especially those with evapo-transpiration and capillary breaks. Typical cap assessments treat the barrier’s structure as static prior to some defined lifetime. Environmental boundary conditions such as precipitation and temperature are treated as time dependent. However, other key elements of the barrier system are regarded as constant, including engineered inputs (e.g., fire management strategy, irrigation, vegetation control), surface ecology (critical to assessment of plant transpiration), capillary break interface, material properties, surface erosion rate, etc. Further, to be conservative, only harmful processes are typically considered. A more holistic examination of both harmful and beneficial processes will provide more realistic pre-service prediction and in-service assessment of performance as well as provide designers a tool to encourage beneficial processes while discouraging harmful processes. Thus
Brandsch, Rainer
2017-10-01
Migration modelling provides reliable migration estimates from food-contact materials (FCM) to food or food simulants based on mass-transfer parameters like diffusion and partition coefficients related to individual materials. In most cases, mass-transfer parameters are not readily available from the literature and for this reason are estimated with a given uncertainty. Historically, uncertainty was accounted for by introducing upper limit concepts first, turning out to be of limited applicability due to highly overestimated migration results. Probabilistic migration modelling gives the possibility to consider uncertainty of the mass-transfer parameters as well as other model inputs. With respect to a functional barrier, the most important parameters among others are the diffusion properties of the functional barrier and its thickness. A software tool that accepts distribution as inputs and is capable of applying Monte Carlo methods, i.e., random sampling from the input distributions of the relevant parameters (i.e., diffusion coefficient and layer thickness), predicts migration results with related uncertainty and confidence intervals. The capabilities of probabilistic migration modelling are presented in the view of three case studies (1) sensitivity analysis, (2) functional barrier efficiency and (3) validation by experimental testing. Based on the predicted migration by probabilistic migration modelling and related exposure estimates, safety evaluation of new materials in the context of existing or new packaging concepts is possible. Identifying associated migration risk and potential safety concerns in the early stage of packaging development is possible. Furthermore, dedicated material selection exhibiting required functional barrier efficiency under application conditions becomes feasible. Validation of the migration risk assessment by probabilistic migration modelling through a minimum of dedicated experimental testing is strongly recommended.
Stability of the Shallow Axisymmetric Parabolic-Conic Bimetallic Shell by Nonlinear Theory
M. Jakomin
2011-01-01
Full Text Available In this contribution, we discuss the stress, deformation, and snap-through conditions of thin, axi-symmetric, shallow bimetallic shells of so-called parabolic-conic and plate-parabolic type shells loaded by thermal loading. According to the theory of the third order that takes into account the balance of forces on a deformed body, we present a model with a mathematical description of the system geometry, displacements, stress, and thermoelastic deformations. The equations are based on the large displacements theory. We numerically calculate the deformation curve and the snap-through temperature using the fourth-order Runge-Kutta method and a nonlinear shooting method. We show how the temperature of both snap-through depends on the point where one type of the rotational curve transforms into another.