WorldWideScience

Sample records for model par excellence

  1. Hydropersulfides: H-Atom Transfer Agents Par Excellence.

    Science.gov (United States)

    Chauvin, Jean-Philippe R; Griesser, Markus; Pratt, Derek A

    2017-05-10

    Hydropersulfides (RSSH) are formed endogenously via the reaction of the gaseous biotransmitter hydrogen sulfide (H 2 S) and disulfides (RSSR) and/or sulfenic acids (RSOH). RSSH have been investigated for their ability to store H 2 S in vivo and as a line of defense against oxidative stress, from which it is clear that RSSH are much more reactive to two-electron oxidants than thiols. Herein we describe the results of our investigations into the H-atom transfer chemistry of RSSH, contrasting it with the well-known H-atom transfer chemistry of thiols. In fact, RSSH are excellent H-atom donors to alkyl (k ∼ 5 × 10 8 M -1 s -1 ), alkoxyl (k ∼ 1 × 10 9 M -1 s -1 ), peroxyl (k ∼ 2 × 10 6 M -1 s -1 ), and thiyl (k > 1 × 10 10 M -1 s -1 ) radicals, besting thiols by as little as 1 order and as much as 4 orders of magnitude. The inherently high reactivity of RSSH to H-atom transfer is based largely on thermodynamic factors; the weak RSS-H bond dissociation enthalpy (∼70 kcal/mol) and the associated high stability of the perthiyl radical make the foregoing reactions exothermic by 15-34 kcal/mol. Of particular relevance in the context of oxidative stress is the reactivity of RSSH to peroxyl radicals, where favorable thermodynamics are bolstered by a secondary orbital interaction in the transition state of the formal H-atom transfer that drives the inherent reactivity of RSSH to match that of α-tocopherol (α-TOH), nature's premier radical-trapping antioxidant. Significantly, the reactivity of RSSH eclipses that of α-TOH in H-bond-accepting media because of their low H-bond acidity (α 2 H ∼ 0.1). This affords RSSH a unique versatility compared to other highly reactive radical-trapping antioxidants (e.g., phenols, diarylamines, hydroxylamines, sulfenic acids), which tend to have high H-bond acidities. Moreover, the perthiyl radicals that result are highly persistent under autoxidation conditions and undergo very rapid dimerization (k = 5 × 10 9 M -1 s -1 ) in

  2. The Business Excellence Model for CSR Implementation?

    DEFF Research Database (Denmark)

    Neergaard, Peter; Gjerdrum Pedersen, Esben Rahbek

    2012-01-01

    Most of the Fortune 500 companies address Corporate Social Responsibility (CSR) on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating...... European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus....

  3. Solving rational expectations models using Excel

    DEFF Research Database (Denmark)

    Strulik, Holger

    2004-01-01

    Problems of discrete time optimal control can be solved using backward iteration and Microsoft Excel. The author explains the method in general and shows how the basic models of neoclassical growth and real business cycles are solved......Problems of discrete time optimal control can be solved using backward iteration and Microsoft Excel. The author explains the method in general and shows how the basic models of neoclassical growth and real business cycles are solved...

  4. Nostoc sphaeroides Kütz, a candidate producer par excellence for CELSS

    Science.gov (United States)

    Wang, Gaohong; Hao, Zongjie; Liu, Yongding

    A lot of aquatic organisms could be regarded as suitable candidates par excellence in the establishment of CELSS, since they are relatively easy and fast to grow and resistant to changes in environmental condition as well as providing nutritious, protein-and vitamin-rich foods for the crew, which can fulfill the main functions of CELSS, including supplying oxygen, water and food, removing carbon dioxide and making daily life waste reusable. Our labotory has developed mass culture of Nostoc sphaeroides Kütz, which is one of traditional healthy food in China and. The oxygen evolution rate of the cyanobacterium is about 150 molO2.mg-1.h-1, and it usually grows into colony with size between 2-20mm, which is easy to be harvested. It also can be cultured with high density, which show that the productivity of the cyanobacterium in limited volume is higher than other microalgae. We had measured the nutrient content of the cyanobacterium and developed some Chinese Dishes and Soups with Nostoc sphaeroides Kütz, which showed that it was a good food for crew. Using remote sensing technique, we also investigated its growth in Closed System under microgravity by SHENZHOU-2 spacecraft in January 2001. We plan to develop suitable bioreactor with the cyanobacterium for supplying oxygen and food to crew in future.

  5. The Business Excellence Model for CSR Implementation?

    Directory of Open Access Journals (Sweden)

    Neergaard Peter

    2014-11-01

    Full Text Available Most of the Fortune 500 companies address Corporate Social Responsibility (CSR on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating quality in organizations. CSR was first introduced in the model in 2002. From 2004 the European Foundation for Quality Management (EFQM has been eager to promote the model as an effective tool for implementing CSR.. The article discusses the potentials of the model for this end and illustrates how a 2006 European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus.

  6. Equilibrator: Modeling Chemical Equilibria with Excel

    Science.gov (United States)

    Vander Griend, Douglas A.

    2011-01-01

    Equilibrator is a Microsoft Excel program for learning about chemical equilibria through modeling, similar in function to EQS4WIN, which is no longer supported and does not work well with newer Windows operating systems. Similar to EQS4WIN, Equilibrator allows the user to define a system with temperature, initial moles, and then either total…

  7. Role modeling excellence in clinical nursing practice.

    Science.gov (United States)

    Perry, R N Beth

    2009-01-01

    Role modeling excellence in clinical nursing practice is the focus of this paper. The phenomenological research study reported involved a group of 8 nurses identified by their colleagues as exemplary. The major theme revealed in this study was that these exemplary nurses were also excellent role models in the clinical setting. This paper details approaches used by these nurses that made them excellent role models. Specifically, the themes of attending to the little things, making connections, maintaining a light-hearted attitude, modeling, and affirming others are presented. These themes are discussed within the framework of Watson [Watson, J., 1989. Human caring and suffering: a subjective model for health services. In: Watson, J., Taylor, R. (Eds.), They Shall Not Hurt: Human Suffering and Human Caring. Colorado University, Boulder, CO] "transpersonal caring" and [Bandura, A., 1997. Social Learning Theory. Prentice Hall, Englewood Cliffs, NJ] "Social Learning Theory." Particular emphasis in the discussion is on how positive role modeling by exemplary practitioners can contribute to the education of clinical nurses in the practice setting.

  8. Overcoming Microsoft Excel's Weaknesses for Crop Model Building and Simulations

    Science.gov (United States)

    Sung, Christopher Teh Boon

    2011-01-01

    Using spreadsheets such as Microsoft Excel for building crop models and running simulations can be beneficial. Excel is easy to use, powerful, and versatile, and it requires the least proficiency in computer programming compared to other programming platforms. Excel, however, has several weaknesses: it does not directly support loops for iterative…

  9. Brahmagupta, Mathematician Par Excellence

    Indian Academy of Sciences (India)

    mathematical and scientific activity for the next millen- nium until the Renaissance in ... (BrSpSi XII.38) This sloka describes the method of obtaining a rational cyclic quadrilateral using two nonsimilar rational right triangles. (This seems to be.

  10. An integrated service excellence model for military test and ...

    African Journals Online (AJOL)

    The purpose of this article is to introduce an Integrated Service Excellence Model (ISEM) for empowering the leadership core of the capital-intensive military test and evaluation facilities to provide strategic military test and evaluation services and to continuously improve service excellence by ensuring that all activities ...

  11. Promoting Excellence in Nursing Education (PENE): Pross evaluation model.

    Science.gov (United States)

    Pross, Elizabeth A

    2010-08-01

    The purpose of this article is to examine the Promoting Excellence in Nursing Education (PENE) Pross evaluation model. A conceptual evaluation model, such as the one described here, may be useful to nurse academicians in the ongoing evaluation of educational programs, especially those with goals of excellence. Frameworks for evaluating nursing programs are necessary because they offer a way to systematically assess the educational effectiveness of complex nursing programs. This article describes the conceptual framework and its tenets of excellence. Copyright 2009 Elsevier Ltd. All rights reserved.

  12. Comparative Analysis Of Three Largest World Models Of Business Excellence

    Directory of Open Access Journals (Sweden)

    Jasminka Samardžija

    2009-07-01

    Full Text Available Business excellence has become the strongest means of achieving competitive advantage of companies while total management of quality has become the road that ensures support of excellent results recognized by many world companies. Despite many differences, we can conclude that models have many common elements. By the audit in 2005, the DP and MBNQA moved the focus from excellence of product, i.e service, onto the excellence of quality of the entire organization process. Thus, the quality got strategic dimension instead of technical one and the accent passed from the technical quality on the total excellence of all organization processes. The joint movement goes to the direction of good management and appreciation of systems thinking. The very structure of EFOM model criteria itself is adjusted to strategic dimension of quality and that is why the model underwent only short audits within the criteria themselves. Essentially, the model remained unchanged. In all models, the accent is on the satisfaction of buyers, employees and community. National rewards for quality have an important role in promotion and giving a prize to excellence in organization performances. Moreover, they raise quality standards of companies and the country profile as a whole. Considering the GDP per capita and the percentage of certification level of companies, Croatia has all the predispositions for introduction the EFQM model of business excellence with the basic aim of deficit decrease in foreign trade balance and strengthening of competitiveness as the necessary preliminary work for the entrance in the competitive market of the EU. Quality management was introduced in many organizations. The methods used at that time developed in the course of years, and what are to predict is the continuation of the evolution road model as well as the method of business excellence.

  13. Proposing an Environmental Excellence Self-Assessment Model

    DEFF Research Database (Denmark)

    Meulengracht Jensen, Peter; Johansen, John; Wæhrens, Brian Vejrum

    2013-01-01

    that the EEA model can be used in global organizations to differentiate environmental efforts depending on the maturity stage of the individual sites. Furthermore, the model can be used to support the decision-making process regarding when organizations should embark on more complex environmental efforts......This paper presents an Environmental Excellence Self-Assessment (EEA) model based on the structure of the European Foundation of Quality Management Business Excellence Framework. Four theoretical scenarios for deploying the model are presented as well as managerial implications, suggesting...

  14. Designing organizational excellence model for cellulose industry of Iran

    Directory of Open Access Journals (Sweden)

    Seyed Abbas Kazemi

    2012-01-01

    Full Text Available Nowadays organizational excellence is regarded as the world’s most effective and progressive issue and many countries and organizations are attempting in the way of applying excellence. In this way, they attempt to improve such models and according to culture and sociopolitical conditions of each country, they attempt to design several models. The present research has been conducted with principal goal of designing organizational excellence model at cellulose industry of Iran. The study determines its components and aspects, priorities the aspects and components and analyzes relationship among different aspects of organizational excellence model at cellulose industry of Iran. The present research is an applied research with respect to goal and it is a descriptive-analytical method in terms of method. Statistical population of the present research covers all experts in the field of cellulose industry of Iran in which on this basis, the number of statistical sample was 207 people from managers to specialists. Results of research indicate that organizational excellence pattern of cellulose industry is a mixture of different aspects of technical, economic, inner environment, outer environment, motivation and behavioral processes.

  15. PEP-II vacuum system pressure profile modeling using EXCEL

    International Nuclear Information System (INIS)

    Nordby, M.; Perkins, C.

    1994-06-01

    A generic, adaptable Microsoft EXCEL program to simulate molecular flow in beam line vacuum systems is introduced. Modeling using finite-element approximation of the governing differential equation is discussed, as well as error estimation and program capabilities. The ease of use and flexibility of the spreadsheet-based program is demonstrated. PEP-II vacuum system models are reviewed and compared with analytical models

  16. Microsoft Office Excel 2007 data analysis and business modeling

    CERN Document Server

    Winston, Wayne L

    2007-01-01

    Master the analysis and business modeling techniques that help you transform your data into bottom-line results. Award-winning business professor and corporate consultant Wayne Winston shares the best of his real-world experience in this practical guide-now updated for Excel 2007. Use Wayne's proven practices and hands-on exercises to help you work smarter, make better decisions, and gain the competitive edge. Solve real-world business problems with Excel 2007! Maximize profits-determine NPV, optimize your product mix, calculate ROICreate best, worst, and most-likely case scenarios for sal

  17. An EFQM excellence model for integrated healthcare governance.

    Science.gov (United States)

    Favaretti, Carlo; De Pieri, Paolo; Torri, Emanuele; Guarrera, Giovanni; Fontana, Fabrizio; Debiasi, Franco; Flor, Luciano

    2015-01-01

    The purpose of this paper is to account for a ten-year experience with the European Foundation for Quality Management (EFQM) Excellence Model implemented in the Trento Healthcare Trust. Since 2000, the EFQM Excellence Model provided an overarching framework to streamline business process governance, to support and improve its enablers and results. From 2000 to 2009, staff performed four internal (self) and four external EFQM-based assessments that provided guidance for an integrated management system. Over the years, key controls and assurances improved service quality through business planning, learning and practice cycles. Rising assessment ratings and improving results characterized the journey. The average self-assessment score (on a 1,000 points scale) was 290 in 2001, which increased to 610 in 2008. Since 2006, the Trust has been Recognized for Excellence (four stars). The organization improved significantly on customer satisfaction, people results and key service delivery and outcomes. The EFQM Model can act as an effective tool to meet governance demands and promote system-level results. The approach to integrated governance discussed here may support similar change processes in comparable organizations. The paper describes a unique experience when implementing EFQM within a large Italian healthcare system, which had a broader reach and lasted longer than any experience in Italian healthcare.

  18. Protease-activated receptor (PAR2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

    Directory of Open Access Journals (Sweden)

    Lisa G van den Hengel

    Full Text Available AIMS: In collateral development (i.e. arteriogenesis, mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. METHODS AND RESULTS: PAR1-deficient (PAR1-/-, PAR2-deficient (PAR2-/- and wild-type (WT mice underwent femoral artery ligation. Laser Doppler measurements revealed reduced post-ischemic blood flow recovery in PAR2-/- hind limbs when compared to WT, while PAR1-/- mice were not affected. Upon ischemia, reduced numbers of smooth muscle actin (SMA-positive collaterals and CD31-positive capillaries were found in PAR2-/- mice when compared to WT mice, whereas these parameters in PAR1-/- mice did not differ from WT mice. The pool of circulating repair-associated (Ly6C-low monocytes and the number of repair-associated (CD206-positive macrophages surrounding collaterals in the hind limbs were increased in WT and PAR1-/- mice, but unaffected in PAR2-/- mice. The number of repair-associated macrophages in PAR2-/- hind limbs correlated with CD11b- and CD115-expression on the circulating monocytes in these animals, suggesting that monocyte extravasation and M-CSF-dependent differentiation into repair-associated cells are hampered. CONCLUSION: PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD patients.

  19. Profit Forecast Model Using Monte Carlo Simulation in Excel

    Directory of Open Access Journals (Sweden)

    Petru BALOGH

    2014-01-01

    Full Text Available Profit forecast is very important for any company. The purpose of this study is to provide a method to estimate the profit and the probability of obtaining the expected profit. Monte Carlo methods are stochastic techniques–meaning they are based on the use of random numbers and probability statistics to investigate problems. Monte Carlo simulation furnishes the decision-maker with a range of possible outcomes and the probabilities they will occur for any choice of action. Our example of Monte Carlo simulation in Excel will be a simplified profit forecast model. Each step of the analysis will be described in detail. The input data for the case presented: the number of leads per month, the percentage of leads that result in sales, , the cost of a single lead, the profit per sale and fixed cost, allow obtaining profit and associated probabilities of achieving.

  20. Model voor Excellent voor cognitief excellente leerlingen in de onderbouw PO

    NARCIS (Netherlands)

    Dijkstra, Elma; Mooij, Ton; Kirschner, Paul A.

    2012-01-01

    Dijkstra, E. M., Mooij, T., & Kirschner, P. A. (2012, June). Model voor Excellent Onderwijs voor cognitief excellent leerlingen in de onderbouw PO. [Model of Excellent Education for cognitively excellent pupils in kindergarten]. Paper presented at the Onderwijs Research Dagen [Educational Research

  1. Excel Spreadsheets for Algebra: Improving Mental Modeling for Problem Solving

    Science.gov (United States)

    Engerman, Jason; Rusek, Matthew; Clariana, Roy

    2014-01-01

    This experiment investigates the effectiveness of Excel spreadsheets in a high school algebra class. Students in the experiment group convincingly outperformed the control group on a post lesson assessment. The student responses, teacher observations involving Excel spreadsheet revealed that it operated as a mindtool, which formed the users'…

  2. Advanced Modeling in Excel: from Water Jets to Big Bang

    Science.gov (United States)

    Ignatova, Olga; Chyzhyk, D.; Willis, C.; Kazachkov, A.

    2006-12-01

    An international students’ project is presented focused on application of Open Office and Excel spreadsheets for modeling of projectile-motion type dynamical systems. Variation of the parameters of plotted and animated families of jets flowing at different angles out of the holes in the wall of water-filled reservoir [1,2] revealed unexpected peculiarities of the envelopes, vertices, intersections and landing points of virtual trajectories. Comparison with real-life systems and rigorous calculations were performed to prove predictions of computer experiments. By same technique, the kinematics of fireworks was analyzed. On this basis two-dimensional ‘firework’ computer model of Big Bang was designed and studied, its relevance and limitations checked. 1.R.Ehrlich, Turning the World Inside Out, (Princeton University Press, Princeton, NJ, 1990), pp. 98-100. 2.A.Kazachkov, Yu.Bogdan, N.Makarovsky, N.Nedbailo. A Bucketful of Physics, in R.Pinto, S.Surinach (eds), International Conference Physics Teacher Education Beyond 2000. Selected Contributions (Elsevier Editions, Paris, 2001), pp.563-564. Sponsored by Courtney Willis.

  3. Best Practices in Academic Mentoring: A Model for Excellence

    Directory of Open Access Journals (Sweden)

    Jan M. Nick

    2012-01-01

    Full Text Available Mentoring is important for the recruitment and retention of qualified nurse faculty, their ongoing career development, and leadership development. However, what are current best practices of mentoring? The purpose of this paper is to provide an overview of a model for excellence in establishing a formal mentoring program for academic nurse educators. Six themes for establishing a formal mentoring program are presented, highlighting best practices in mentoring as culled from experience and the literature. Themes reflect aims to achieve appropriately matched dyads, establish clear mentorship purpose and goals, solidify the dyad relationship, advocate for and guide the protégé, integrate the protégé into the academic culture, and mobilize institutional resources for mentoring support. Attending to the six themes will help mentors achieve important protégé outcomes, such as orientation to the educator role, integration into the academic community, development of teaching, scholarship, and service skills, as well as leadership development. The model is intended to be generalizable for faculty teaching in a variety of academic nursing institution types and sizes. Mentoring that integrates the six themes assists faculty members to better navigate the academic environment and more easily transition to new roles and responsibilities.

  4. Designing a Knowledge Management Excellence Model Based on Interpretive Structural Modeling

    Directory of Open Access Journals (Sweden)

    Mirza Hassan Hosseini

    2014-09-01

    Full Text Available Despite the development of appropriate academic and experiential background knowledge management and its manifestation as a competitive advantage, many organizations have failed in its effective utilization. Among the reasons for this failure are some deficiencies in terms of methodology in inappropriate recognition and translation of KM dimensions and lack of systematic approach in establishment of causal relationships among KM factors. This article attempts to design an Organizational Knowledge Management Excellence Model. To design an organizational knowledge management excellence model based on library researches, interviews with experts and interpretive-structural modeling (ISM was used in order to identify and determine the relationships between the factors of km excellence. Accordingly, 9 key criteria of KM Excellence as well as 29 sub-criteria were extracted and the relationships and sequence of factors were defined and developed in 5 levels for designing an organizational KM excellence Model. Finally, the concepts were applied in Defense Organizations to illustrate the proposed methodology.

  5. Evaluating treatment process redesign by applying the EFQM Excellence Model.

    Science.gov (United States)

    Nabitz, Udo; Schramade, Mark; Schippers, Gerard

    2006-10-01

    To evaluate a treatment process redesign programme implementing evidence-based treatment as part of a total quality management in a Dutch addiction treatment centre. Quality management was monitored over a period of more than 10 years in an addiction treatment centre with 550 professionals. Changes are evaluated, comparing the scores on the nine criteria of the European Foundation for Quality Management (EFQM) Excellence Model before and after a major redesign of treatment processes and ISO certification. In the course of 10 years, most intake, care, and cure processes were reorganized, the support processes were restructured and ISO certified, 29 evidence-based treatment protocols were developed and implemented, and patient follow-up measuring was established to make clinical outcomes transparent. Comparing the situation before and after the changes shows that the client satisfaction scores are stable, that the evaluation by personnel and society is inconsistent, and that clinical, production, and financial outcomes are positive. The overall EFQM assessment by external assessors in 2004 shows much higher scores on the nine criteria than the assessment in 1994. Evidence-based treatment can successfully be implemented in addiction treatment centres through treatment process redesign as part of a total quality management strategy, but not all results are positive.

  6. [Application of three compartment model and response surface model to clinical anesthesia using Microsoft Excel].

    Science.gov (United States)

    Abe, Eiji; Abe, Mari

    2011-08-01

    With the spread of total intravenous anesthesia, clinical pharmacology has become more important. We report Microsoft Excel file applying three compartment model and response surface model to clinical anesthesia. On the Microsoft Excel sheet, propofol, remifentanil and fentanyl effect-site concentrations are predicted (three compartment model), and probabilities of no response to prodding, shaking, surrogates of painful stimuli and laryngoscopy are calculated using predicted effect-site drug concentration. Time-dependent changes in these calculated values are shown graphically. Recent development in anesthetic drug interaction studies are remarkable, and its application to clinical anesthesia with this Excel file is simple and helpful for clinical anesthesia.

  7. Reducing Excellence Gaps: A Research-Based Model

    Science.gov (United States)

    Plucker, Jonathan A.; Peters, Scott J.; Schmalensee, Stephanie

    2017-01-01

    As the awareness of the existence and negative effects of excellence gaps has grown among educators and policy makers, so too has a desire for research-supported interventions to reduce these gaps. A recent review of research related to promoting equitable outcomes for all gifted students identified six specific strategies for reducing excellence…

  8. CFD modelling of hydrogen stratification in enclosures: Model validation and application to PAR performance

    Energy Technology Data Exchange (ETDEWEB)

    Hoyes, J.R., E-mail: james.hoyes@hsl.gsi.gov.uk; Ivings, M.J.

    2016-12-15

    Highlights: • The ability of CFD to predict hydrogen stratification phenomena is investigated. • Contrary to expectation, simulations on tetrahedral meshes under-predict mixing. • Simulations on structured meshes give good agreement with experimental data. • CFD model used to investigate the effects of stratification on PAR performance. • Results show stratification can have a significant effect on PAR performance. - Abstract: Computational Fluid Dynamics (CFD) models are maturing into useful tools for supporting safety analyses. This paper investigates the capabilities of CFD models for predicting hydrogen stratification in a containment vessel using data from the NEA/OECD SETH2 MISTRA experiments. Further simulations are then carried out to illustrate the qualitative effects of hydrogen stratification on the performance of Passive Autocatalytic Recombiner (PAR) units. The MISTRA experiments have well-defined initial and boundary conditions which makes them well suited for use in a validation study. Results are presented for the sensitivity to mesh resolution and mesh type. Whilst the predictions are shown to be largely insensitive to the mesh resolution they are surprisingly sensitive to the mesh type. In particular, tetrahedral meshes are found to induce small unphysical convection currents that result in molecular diffusion and turbulent mixing being under-predicted. This behaviour is not unique to the CFD model used here (ANSYS CFX) and furthermore, it may affect simulations run on other non-aligned meshes (meshes that are not aligned perpendicular to gravity), including non-aligned structured meshes. Following existing best practice guidelines can help to identify potential unphysical predictions, but as an additional precaution consideration should be given to using gravity-aligned meshes for modelling stratified flows. CFD simulations of hydrogen recombination in the Becker Technologies THAI facility are presented with high and low PAR positions

  9. Modeling post-wildfire hydrological processes with ParFlow

    Science.gov (United States)

    Escobar, I. S.; Lopez, S. R.; Kinoshita, A. M.

    2017-12-01

    Wildfires alter the natural processes within a watershed, such as surface runoff, evapotranspiration rates, and subsurface water storage. Post-fire hydrologic models are typically one-dimensional, empirically-based models or two-dimensional, conceptually-based models with lumped parameter distributions. These models are useful for modeling and predictions at the watershed outlet; however, do not provide detailed, distributed hydrologic processes at the point scale within the watershed. This research uses ParFlow, a three-dimensional, distributed hydrologic model to simulate post-fire hydrologic processes by representing the spatial and temporal variability of soil burn severity (via hydrophobicity) and vegetation recovery. Using this approach, we are able to evaluate the change in post-fire water components (surface flow, lateral flow, baseflow, and evapotranspiration). This work builds upon previous field and remote sensing analysis conducted for the 2003 Old Fire Burn in Devil Canyon, located in southern California (USA). This model is initially developed for a hillslope defined by a 500 m by 1000 m lateral extent. The subsurface reaches 12.4 m and is assigned a variable cell thickness to explicitly consider soil burn severity throughout the stages of recovery and vegetation regrowth. We consider four slope and eight hydrophobic layer configurations. Evapotranspiration is used as a proxy for vegetation regrowth and is represented by the satellite-based Simplified Surface Energy Balance (SSEBOP) product. The pre- and post-fire surface runoff, subsurface storage, and surface storage interactions are evaluated at the point scale. Results will be used as a basis for developing and fine-tuning a watershed-scale model. Long-term simulations will advance our understanding of post-fire hydrological partitioning between water balance components and the spatial variability of watershed processes, providing improved guidance for post-fire watershed management. In reference

  10. Simulation of complex pharmacokinetic models in Microsoft Excel.

    Science.gov (United States)

    Meineke, Ingolf; Brockmöller, Jürgen

    2007-12-01

    With the arrival of powerful personal computers in the office numerical methods are accessible to everybody. Simulation of complex processes therefore has become an indispensible tool in research and education. In this paper Microsoft EXCEL is used as a platform for a universal differential equation solver. The software is designed as an add-in aiming at a minimum of required user input to perform a given task. Four examples are included to demonstrate both, the simplicity of use and the versatility of possible applications. While the layout of the program is admittedly geared to the needs of pharmacokineticists, it can be used in any field where sets of differential equations are involved. The software package is available upon request.

  11. The Y-12 Plant - a model for environmental excellence

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    The Department of Energy`s Y-12 Plant, located in Oak Ridge, Tennessee, occupies more than 800 acres and has a work force of over 4,000 employees. The Y-12 Plant is managed by Martin Marietta Energy Systems, Inc., a subsidiary of Martin Marietta Corporation. Although mission emphases at the Y-12 Plant have evolved and changed with the easing of international tensions, the Plant continues to serve as a key manufacturing unit and technology demonstration center for the Department of Energy and the nation. The Y-12 Plant has undergone many changes in the last 14 years. One of the most dramatic changes has occurred in the environmental programs with measurable improvements in environmental quality, the development of an award-winning pollution prevention program, and the institution of an environmentally-conscious work ethic among the work force. Because the plant is committed to achieving excellence, not just compliance with laws and regulations, a highly structured, multimedia environmental management program is in place. This program, combined with a commitment to protect the environment while striving for continued improvement, has placed Y-12 in the position to reach excellence. As a result of the Y-12 Plant`s changing mission, they are now working closely with American industry through technology transfer to share their experiences and {open_quotes}lessons learned{close_quotes}--including environmental and pollution prevention technology. To facilitate this effort, the Oak Ridge Centers for Manufacturing Technology has been established at the Y-12 Plant. Through the Centers, the Oak Ridge staff applies skills, capabilities, and facilities developed over a 50-year history of the Oak Ridge Complex to a variety of peacetime missions. The services found at the Centers are a key to helping America`s businesses--both small and large--compete in the global marketplace while protecting the nations environment and conserving its resources.

  12. Excellence in Physics Education Award: Modeling Theory for Physics Instruction

    Science.gov (United States)

    Hestenes, David

    2014-03-01

    All humans create mental models to plan and guide their interactions with the physical world. Science has greatly refined and extended this ability by creating and validating formal scientific models of physical things and processes. Research in physics education has found that mental models created from everyday experience are largely incompatible with scientific models. This suggests that the fundamental problem in learning and understanding science is coordinating mental models with scientific models. Modeling Theory has drawn on resources of cognitive science to work out extensive implications of this suggestion and guide development of an approach to science pedagogy and curriculum design called Modeling Instruction. Modeling Instruction has been widely applied to high school physics and, more recently, to chemistry and biology, with noteworthy results.

  13. Excellence and evidence in staffing: a data-driven model for excellence in staffing (2nd edition).

    Science.gov (United States)

    Baggett, Margarita; Batcheller, Joyce; Blouin, Ann Scott; Behrens, Elizabeth; Bradley, Carol; Brown, Mary J; Brown, Diane Storer; Bolton, Linda Burnes; Borromeo, Annabelle R; Burtson, Paige; Caramanica, Laura; Caspers, Barbara A; Chow, Marilyn; Christopher, Mary Ann; Clarke, Sean P; Delucas, Christine; Dent, Robert L; Disser, Tony; Eliopoulos, Charlotte; Everett, Linda Q; Garcia, Amy; Glassman, Kimberly; Goodwin, Susan; Haagenson, Deb; Harper, Ellen; Harris, Kathy; Hoying, Cheryl L; Hughes-Rease, Marsha; Kelly, Lesly; Kiger, Anna J; Kobs-Abbott, Ann; Krueger, Janelle; Larson, Jackie; March, Connie; Martin, Deborah Maust; Mazyck, Donna; Meenan, Penny; McGaffigan, Patricia; Myers, Karen K; Nell, Kate; Newcomer, Britta; Cathy, Rick; O'Rourke, Maria; Rosa, Billy; Rose, Robert; Rudisill, Pamela; Sanford, Kathy; Simpson, Roy L; Snowden, Tami; Strickland, Bob; Strohecker, Sharon; Weems, Roger B; Welton, John; Weston, Marla; Valentine, Nancy M; Vento, Laura; Yendro, Susan

    2014-01-01

    The Patient Protection and Affordable Care Act (PPACA, 2010) and the Institute of Medicine's (IOM, 2011) Future of Nursing report have prompted changes in the U.S. health care system. This has also stimulated a new direction of thinking for the profession of nursing. New payment and priority structures, where value is placed ahead of volume in care, will start to define our health system in new and unknown ways for years. One thing we all know for sure: we cannot afford the same inefficient models and systems of care of yesterday any longer. The Data-Driven Model for Excellence in Staffing was created as the organizing framework to lead the development of best practices for nurse staffing across the continuum through research and innovation. Regardless of the setting, nurses must integrate multiple concepts with the value of professional nursing to create new care and staffing models. Traditional models demonstrate that nurses are a commodity. If the profession is to make any significant changes in nurse staffing, it is through the articulation of the value of our professional practice within the overall health care environment. This position paper is organized around the concepts from the Data-Driven Model for Excellence in Staffing. The main concepts are: Core Concept 1: Users and Patients of Health Care, Core Concept 2: Providers of Health Care, Core Concept 3: Environment of Care, Core Concept 4: Delivery of Care, Core Concept 5: Quality, Safety, and Outcomes of Care. This position paper provides a comprehensive view of those concepts and components, why those concepts and components are important in this new era of nurse staffing, and a 3-year challenge that will push the nursing profession forward in all settings across the care continuum. There are decades of research supporting various changes to nurse staffing. Yet little has been done to move that research into practice and operations. While the primary goal of this position paper is to generate research

  14. A dynamic network model to explain the development of excellent human performance

    Directory of Open Access Journals (Sweden)

    Ruud J.R. Den Hartigh

    2016-04-01

    Full Text Available Across different domains, from sports to science, some individuals accomplish excellent levels of performance. For over 150 years, researchers have debated the roles of specific nature and nurture components to develop excellence. In this article, we argue that the key to excellence does not reside in specific underlying components, but rather in the ongoing interactions among the components. We propose that excellence emerges out of dynamic networks consisting of idiosyncratic mixtures of interacting components such as genetic endowment, motivation, practice, and coaching. Using computer simulations we demonstrate that the dynamic network model accurately predicts typical properties of excellence reported in the literature, such as the idiosyncratic developmental trajectories leading to excellence and the highly skewed distributions of productivity present in virtually any achievement domain. Based on this novel theoretical perspective on excellent human performance, this article concludes by suggesting policy implications and directions for future research.

  15. Schoolwide Enrichment Model: Challenging All Children to Excel

    Science.gov (United States)

    Beecher, Margaret

    2010-01-01

    This article summarizes how the components of the Schoolwide Enrichment Model were used to dramatically reduce the achievement gap in a school with a high at-risk student population. The theories of enrichment and instructional differentiation replaced an existing remedial paradigm and a strength-based methodology was embraced by the school…

  16. Excel simulations

    CERN Document Server

    Verschuuren, Gerard M

    2013-01-01

    Covering a variety of Excel simulations, from gambling to genetics, this introduction is for people interested in modeling future events, without the cost of an expensive textbook. The simulations covered offer a fun alternative to the usual Excel topics and include situations such as roulette, password cracking, sex determination, population growth, and traffic patterns, among many others.

  17. Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis

    Science.gov (United States)

    Stanton, M. Mark; Nelson, Lisa K.; Benediktsson, Hallgrimur; Hollenberg, Morley D.; Buret, Andre G.; Ceri, Howard

    2013-01-01

    Background. Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. Methods. Using a hapten (ethanol-dinitrobenzene sulfonic acid- (DNBS-)) induced prostatitis model with both wild-type and PAR1-null mice, we examined (1) the location of PAR1 in the mouse prostate and (2) the impact of a PAR1-activating peptide (TFLLR-NH2: PAR1-TF) on ethanol-DNBS-induced inflammation. Results. Ethanol-DNBS-induced inflammation was maximal at 2 days. In the tissue, PAR1 was expressed predominantly along the apical acini of prostatic epithelium. Although PAR1-TF on its own did not cause inflammation, its coadministration with ethanol-DNBS reduced all indices of acute prostatitis. Further, PAR1-TF administration doubled the prostatic production of interleukin-10 (IL-10) compared with ethanol-DNBS treatment alone. This enhanced IL-10 was not observed in PAR1-null mice and was not caused by the reverse-sequence receptor-inactive peptide, RLLFT-NH2. Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice. Conclusions. PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis. However, PAR1-TF also diminishes ethanol-DNBS-induced inflammation via a non-PAR1 mechanism by activating an as-yet unknown receptor. PMID:24459330

  18. A Comparison Between Mıcrosoft Excel Solver and Ncss, Spss Routines for Nonlinear Regression Models

    Directory of Open Access Journals (Sweden)

    Didem Tetik Küçükelçi

    2018-02-01

    Full Text Available In this study we have tried to compare the results obtained by Microsoft Excel Solver program with those of NCSS and SPSS in some nonlinear regression models. We fit some nonlinear models to data present in http//itl.nist.gov/div898/strd/nls/nls_main.shtml by the three packages. Although EXCEL did not succeed as well as the other packages, we conclude that Microsoft Excel Solver provides us a cheaper and a more interactive way of studying nonlinear models.

  19. Physiologically based pharmacokinetic modeling using microsoft excel and visual basic for applications.

    Science.gov (United States)

    Marino, Dale J

    2005-01-01

    Abstract Physiologically based pharmacokinetic (PBPK) models are mathematical descriptions depicting the relationship between external exposure and internal dose. These models have found great utility for interspecies extrapolation. However, specialized computer software packages, which are not widely distributed, have typically been used for model development and utilization. A few physiological models have been reported using more widely available software packages (e.g., Microsoft Excel), but these tend to include less complex processes and dose metrics. To ascertain the capability of Microsoft Excel and Visual Basis for Applications (VBA) for PBPK modeling, models for styrene, vinyl chloride, and methylene chloride were coded in Advanced Continuous Simulation Language (ACSL), Excel, and VBA, and simulation results were compared. For styrene, differences between ACSL and Excel or VBA compartment concentrations and rates of change were less than +/-7.5E-10 using the same numerical integration technique and time step. Differences using VBA fixed step or ACSL Gear's methods were generally Excel and VBA PBPK model dose metrics differed by no more than -0.013% or -0.23%, respectively, from ACSL results. These differences are likely attributable to different step sizes rather than different numerical integration techniques. These results indicate that Microsoft Excel and VBA can be useful tools for utilizing PBPK models, and given the availability of these software programs, it is hoped that this effort will help facilitate the use and investigation of PBPK modeling.

  20. Modelling accidental releases of tritium in the environment: application as an excel spreadsheet

    International Nuclear Information System (INIS)

    Le Dizes, S.; Tamponnet, C.

    2004-01-01

    An application as an Excel spreadsheet of the simplified modelling approach of tritium transfer in the environment developed by Tamponnet (2002) is presented. Based on the use of growth models of biological systems (plants, animals, etc.), the two-pool model (organic tritium and tritiated water) that was developed estimates the concentration of tritium within the different compartments of the food chain and in fine the dose to man by ingestion in the case of a chronic or accidental release of tritium in a river or the atmosphere. Data and knowledge have been implemented on Excel using the object-oriented programming language VisualBasic (Microsoft Visual Basic 6.0). The structure of the conceptual model and the Excel sheet are first briefly exposed. A numerical application of the model under a scenario of an accidental release of tritium in the atmosphere is then presented. Simulation results and perspectives are discussed. (author)

  1. Modelling accidental releases of carbon 14 in the environment: application as an excel spreadsheet

    International Nuclear Information System (INIS)

    Le Dizes, S.; Tamponnet, C.

    2004-01-01

    An application as an Excel spreadsheet of the simplified modelling approach of carbon 14 transfer in the environment developed by Tamponnet (2002) is presented. Based on the use of growth models of biological systems (plants, animals, etc.), the one-pool model (organic carbon) that was developed estimates the concentration of carbon 14 within the different compartments of the food chain and in fine the dose to man by ingestion in the case of a chronic or accidental release of carbon 14 in a river or the atmosphere. Data and knowledge have been implemented on Excel using the object-oriented programming language VisualBasic (Microsoft Visual Basic 6.0). The structure of the conceptual model and the Excel sheet are first briefly exposed. A numerical application of the model under a scenario of an accidental release of carbon 14 in the atmosphere is then presented. Simulation results and perspectives are discussed. (author)

  2. Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

    Czech Academy of Sciences Publication Activity Database

    Olejár, Tomáš; Větvička, D.; Zadinová, M.; Poučková, P.; Kukal, J.; Ježek, Petr; Matěj, R.

    2014-01-01

    Roč. 34, č. 7 (2014), s. 3511-3515 ISSN 0250-7005 R&D Projects: GA ČR(CZ) GAP302/10/0346 Institutional support: RVO:67985823 Keywords : PAR2 * melanoma * metastasis * murine model Subject RIV: EA - Cell Biology Impact factor: 1.826, year: 2014

  3. Sales Training for Army Recruiter Success: Modeling the Sales Strategies and Skills of Excellent Recruiters

    Science.gov (United States)

    1987-11-01

    strategies used by excellent Army recruiters. Neurolinguistic programming (NLP) was used as the protocol for modeling performance and acquiring...Behavioral and Social Sciences 3001 Eisenhower Avenue, Alexandria, VA 22333-5600 10. PROGRAM ELEMENT. PROJECT. TASK ARE* 4 WORK UNIT...Modeling ’Expert knowledge,, Neurolinguistics Knowledge engineering; Recruiting Sales, &’ Sales cycle Sales skills Sales strategies 20

  4. Sucralfate modulates uPAR and EGFR expression in an experimental rat model of cervicitis.

    Science.gov (United States)

    Mannari, C; Santi, S; Migliori, M; Filippi, C; Origlia, N; Sansò, M; Boldrini, E; Giovannini, L

    2008-01-01

    Sucralfate is a drug used in the treatment of gastric and duodenal ulcer; it is cytoprotective and able to increase the bioavailability of several growth factors, modulating the wound healing process. In this study we tested the possible therapeutic effect of Sucralfate in the treatment of ulcerative lesions occurring in uterine cervix; to investigate such effect we used an experimental rat model of cervicitis in which the uPAR and EGFR expression were evaluated. Cervicitis was induced in wild and ovariectomized Wistar female rats by an acetic acid-soaked tampon. The animals were divided into two main groups (4 and 7 days) and Sucralfate was administered topically until the day they were sacrificed. In order to distinguish physiological and drug-induced healing, quantitative and qualitative uPAR and EGFR expression were evaluated by using Western blot and Immunohistochemistry techniques. Western blot analysis demonstrated an increased expression of both receptors after 4 days from wounding in wild and ovariectomized animals. In particular in ovariectomized animals the expression of uPAR and EGFR increased after 4 days while it reduced following the administration of Sucralfate. In wild rats the same was observed for uPAR expression, while EGFR was different; in fact, its expression increased significantly at day 4 in the animals treated with the drug and only at day 7 in those untreated. Immunohistochemistry highlighted a noteworthy epithelial colocalization of EGFR and uPAR after 4 days in the animals treated with Sucralfate. We conclude that Sucralfate can promote the healing of ulcerative cervicitis and moreover, it reduces the normal healing time because of its modulatory property on uPAR and EGFR expression.

  5. A Survey of Level of Excellence in National Library and Archives of I.R. of Iran Based on EFQM Excellence Model

    Directory of Open Access Journals (Sweden)

    Elaheh Hassanzadeh

    2013-03-01

    Full Text Available EFQM excellence model as a framework for evaluation and improvement in organizations indicates some advantages which an excellent organization should achieve. Furthermore, based on its position and the type of service it offers, NLAI needs an all-out study using EFQM model. So the current research aimed at determining level of excellence in NLAI based on EFQM excellence model. The research method was descriptive. Statistical society consisted of top and middle managers of NLAI. Data was gathered through the proportionate EFQM's 90 questions questionnaire. The results from descriptive statistics showed that the mean of NLAI performance self-assessment was acquired in 9 criteria of EFQM model: leadership 56 out of 100, policy and strategy 34 out of 80, people 52 out of 90, partnership and resources 62 out of 90, processes 41 out of 140, customer results 80 out of 200, people results40 out of 90, society results 31 out of 60, key performance results 96 out of 150. Finally, the NLAI gained 492 out of 1000 points. Among all the criteria of the model, partnership criteria and resources have achieved the highest score (62 points of 90 and process criteria lowest score (41 points of 140. Therefore NLAI should be improving the process to meet the complete satisfaction and added value for users and other stakeholders. The results also showed that the EFQM was a good framework for self-assessment on of the EFQM model at NLAI and a good system for identifying strengths and areas for improvement.

  6. Towards a Multi-Stakeholder-Driven Model for Excellence in Higher Education Curriculum Development

    Science.gov (United States)

    Meyer, M. H.; Bushney, M. J.

    2008-01-01

    A multi-stakeholder-driven model for excellence in higher education curriculum development has been developed. It is based on the assumption that current efforts to curriculum development take place within a framework of limited stakeholder consultation. A total of 18 multiple stakeholders are identified, including learners, alumni, government,…

  7. TQM and firms performance: An EFQM excellence model research based survey

    Directory of Open Access Journals (Sweden)

    Santos-Vijande, M. L.

    2007-01-01

    Full Text Available The purpose of this article is to develop an instrument for measuring TQM implementation following the European Foundation for Quality Management Excellence Model and to provide empirical evidence on the relationship between management practices and measures of business performance in the model. To this end, the study employs survey data collected from Spanish manufacturing and service firms. Confirmatory factor analysis is used to test the psychometric properties of the measurement scales and the hypothesized relationships between total quality management practices and organizational performance are examined using structural equation modeling. The findings of the research indicate that the adoption of the TQM practices suggested in the EFQM Excellence Model allows firms to outperform their competitors in the results criteria included in the Model. Therefore, this paper provides a valuable benchmarking data for firms as it substantiates the EFQM Enabler’s contribution to the attainment of competitive advantage.

  8. The Road to Excellence: : A Case Study of the Application of GMP, ISO 9001 and the EFQM Excellence Model in a Nuclear Medicine Department

    NARCIS (Netherlands)

    van Huizen, L; Ahaus, C.T.B. (Kees)

    2017-01-01

    Definitions are introduced to give insight in the field of work of Quality Management in relation to responsibilities in Nuclear Medicine and Molecular Imaging. A relation model visualizes the relationships. When working on the Road to Quality Excellence. The standards as GMP, GCP, ISO 9001 and EFQM

  9. CROSS-CORRELATION MODELLING OF SURFACE WATER – GROUNDWATER INTERACTION USING THE EXCEL SPREADSHEET APPLICATION

    Directory of Open Access Journals (Sweden)

    Kristijan Posavec

    2017-01-01

    Full Text Available Modelling responses of groundwater levels in aquifer systems, which occur as a reaction to changes in aquifer system boundary conditions such as river or stream stages, is commonly being studied using statistical methods, namely correlation, cross-correlation and regression methods. Although correlation and regression analysis tools are readily available in Microsoft Excel, a widely applied spreadsheet industry standard, the cross-correlation analysis tool is missing. As a part of research of groundwater pressure propagation into alluvial aquifer systems of the Sava and Drava/Danube River catchments following river stages rise, focused on estimating groundwater pressure travel times in aquifers, an Excel spreadsheet data analysis application for cross-correlation modelling has been designed and used in modelling surface water – groundwater interaction. Examples of fi eld data from the Zagreb aquifer system and the Kopački rit Nature Park aquifer system are used to illustrate the usefulness of the cross-correlation application.

  10. CFD Recombiner Modelling and Validation on the H2-Par and Kali-H2 Experiments

    International Nuclear Information System (INIS)

    Mimouni, S.; Mechitoua, N.; Ouraou, M.

    2011-01-01

    A large amount of Hydrogen gas is expected to be released within the dry containment of a pressurized water reactor (PWR), shortly after the hypothetical beginning of a severe accident leading to the melting of the core. According to local gas concentrations, the gaseous mixture of hydrogen, air and steam can reach the flammability limit, threatening the containment integrity. In order to prevent mechanical loads resulting from a possible conflagration of the gas mixture, French and German reactor containments are equipped with passive autocatalytic recombiners (PARs) which preventively oxidize hydrogen for concentrations lower than that of the flammability limit. The objective of the paper is to present numerical assessments of the recombiner models implemented in CFD solvers NEPTUNE C FD and Code S aturne. Under the EDF/EPRI agreement, CEA has been committed to perform 42 tests of PARs. The experimental program named KALI-H 2 , consists checking the performance and behaviour of PAR. Unrealistic values for the gas temperature are calculated if the conjugate heat transfer and the wall steam condensation are not taken into account. The combined effects of these models give a good agreement between computational results and experimental data

  11. Business statistics for competitive advantage with Excel 2016 basics, model building, simulation and cases

    CERN Document Server

    Fraser, Cynthia

    2016-01-01

    The revised Fourth Edition of this popular textbook is redesigned with Excel 2016 to encourage business students to develop competitive advantages for use in their future careers as decision makers. Students learn to build models using logic and experience, produce statistics using Excel 2016 with shortcuts, and translate results into implications for decision makers. The textbook features new examples and assignments on global markets, including cases featuring Chipotle and Costco. Exceptional managers know that they can create competitive advantages by basing decisions on performance response under alternative scenarios, and managers need to understand how to use statistics to create such advantages. Statistics, from basic to sophisticated models, are illustrated with examples using real data such as students will encounter in their roles as managers. A number of examples focus on business in emerging global markets with particular emphasis on emerging markets in Latin America, China, and India. Results are...

  12. The EFQM Excellence Model: An Exploratory Attempt for Assessing the Hellenic National Sport Federations

    OpenAIRE

    Dimitris Karastathis; Υiannis Afthinos; Dimitris Gargalianos; Nicholas D. Theodorakis

    2014-01-01

    The EFQM Excellence Model is an advanced tool for organizations’ improvement, which is based on the principles of the theoretical frame of Total Quality Management (Michalska, 2008). The aim of this study was a first attempt to assess the Hellenic National Sport Federations’ (HNSFs) organizational-managerial operations and the investigation of their readiness degree for the application of Management Excellence’s processes, according to European Foundation of Quality Management (EFQM) Excellen...

  13. Multidisciplinary Management: Model of Excellence in the Management Applied to Products and Services

    OpenAIRE

    Guerreiro , Evandro ,; Costa Neto , Pedro ,; Moreira Filho , Ulysses ,

    2014-01-01

    Part 1: Knowledge-Based Performance Improvement; International audience; The Multidisciplinary Management is the guiding vision of modern organizations and the systems thinking which requires new approaches to organizational excellence and quality management process. The objective of this article is to present a model for multidisciplinary management of quality applied to products and services based on American, Japanese, and Brazilian National Quality Awards. The methodology used to build th...

  14. Is there any link between accreditation programs and the models of organizational excellence?

    Directory of Open Access Journals (Sweden)

    Fernando Tobal Berssaneti

    Full Text Available Abstract OBJECTIVE To evaluate whether accredited health organizations perform better management practices than non-accredited ones. METHOD The study was developed in two stages: a literature review, and a study of multiple cases in 12 healthcare organizations in the state of São Paulo, Brazil. It surveyed articles comparing hospital accreditation with the EFQM (European Foundation for Quality Management model of excellence in management. According to the pertinent literature, the accreditation model and the EFQM model are convergent and supplementary in some aspects. RESULTS With 99% confidence, one can say that there is evidence that accredited organizations scored better in the evaluation based on the EFQM model in comparison to non-accredited organizations. This result was also confirmed in the comparison of results between the categories Facilitators and Results in the EFQM model. CONCLUSION There is convergence between the accreditation model and the EFQM excellence model, suggesting that accreditation helps the healthcare sector to implement the best management practices already used by other business sectors.

  15. Evaluation of sustainable development using business excellence model in used motor oil industries

    Directory of Open Access Journals (Sweden)

    Malek Hassanpour

    2014-10-01

    Full Text Available Business and commerce are a chance to create wealth and economic development in companies and industries. Leader of companies must be containing a sense of relief and hope as one of the factors of production and wealth to enhance trust, cooperation between the organization and the community. In order to achieve at the Business Excellence (BE is emphasized to the need for the simultaneous measurement of organizational performance on the Critical Success Factors (CSFs, environmental, social issues and challenges. Objective of current study was to evaluate of sustainable development in used motor oil industry using BE models. Therefore, a framework was discussed as distinct from other common practices to measure performance of an industry. The models allow multi -dimensional focuses on different indicators of the organization's internal, external and CSFs. The check list method was used to collect data in site of industry in the present study. Then, obtained results were surveyed by models such as the Malcolm Baldrige National Quality Award (MBNQA, European Federation for Quality Management (EFQM and Kanji’s Business Excellence Model (KBEM. Results of current analyze indicated that despite the fact that these models and approaches are different, but they are same in term of shared concepts. Finally, we can be able to say that the simultaneous implementation of these models and approaches can be a suitable process in the study of sustainable development of organizations. According to the obtained results of models, the case study industry was in sustainable development conditions.

  16. EMPIRICAL ASSESSMENT OF MICROFINANCE BANKS IN NIGERIA USING EFQM EXCELLENCE MODEL

    Directory of Open Access Journals (Sweden)

    Chijioke Nwachukwu

    2017-06-01

    Full Text Available Measuring the performance of microfinance banks ensure that the banks create value for their various stakeholders. Achieving and sustaining superior business performance is important for organisations. The goal of this study is to assess microfinance banks in Nigeria using EFQM Excellence Model. The study adapts the EFQM self- assessment questionnaire for collecting data from 53 senior staff of selected Microfinance banks in Nigeria. In analyzing our data, Pearson correlation, ANOVA, and multiple regression techniques were used. The result shows that a significant positive association exists between the enablers (leadership, strategy, people, partnerships and resources, processes, products, and services and results (customer, people, society, and business criterion. More important, all the 4 hypotheses are supported. The authors suggest that a robust performance management system that integrates leadership, strategy, people, resources, processes, products, and services are important to achieve and sustain excellent results for various stakeholders.

  17. Paul Halmos – Expositor Par Excellence

    Indian Academy of Sciences (India)

    Administrator

    com plished P hD student of H alm os { w rites about his extraordinary ..... gies on the set ofm easure-preserving transform ations of. a m easure .... reer and book-w riting skills w ere o® and running. ... She still lives at L os G atos, C alifor- nia.

  18. Is there any link between accreditation programs and the models of organizational excellence?

    Science.gov (United States)

    Berssaneti, Fernando Tobal; Saut, Ana Maria; Barakat, Májida Farid; Calarge, Felipe Araujo

    2016-01-01

    To evaluate whether accredited health organizations perform better management practices than non-accredited ones. The study was developed in two stages: a literature review, and a study of multiple cases in 12 healthcare organizations in the state of São Paulo, Brazil. It surveyed articles comparing hospital accreditation with the EFQM (European Foundation for Quality Management) model of excellence in management. According to the pertinent literature, the accreditation model and the EFQM model are convergent and supplementary in some aspects. With 99% confidence, one can say that there is evidence that accredited organizations scored better in the evaluation based on the EFQM model in comparison to non-accredited organizations. This result was also confirmed in the comparison of results between the categories Facilitators and Results in the EFQM model. There is convergence between the accreditation model and the EFQM excellence model, suggesting that accreditation helps the healthcare sector to implement the best management practices already used by other business sectors. Avaliar se as organizações de saúde acreditadas possuem melhores práticas de gestão do que as não acreditadas. A pesquisa foi dividida em duas etapas: revisão da literatura e estudo de casos múltiplos com 12 organizações de saúde, localizadas no estado de São Paulo ‒ Brasil. Foram pesquisados artigos que comparavam a acreditação hospitalar com o modelo de excelência em gestão da EFQM (European Foundation for Quality Management), sendo que a literatura pertinente considera que o modelo de acreditação e o modelo da EFQM são convergentes e, ao mesmo tempo, complementares em determinados aspectos. Com 99% de confiança, pode-se afirmar que há evidência de que as organizações com acreditação obtiveram uma pontuação maior na avaliação baseada no modelo EFQM comparativamente às organizações não acreditadas. Este resultado também se confirmou na comparação dos

  19. Designing Excellence and Quality Model for Training Centers of Primary Health Care: A Delphi Method Study.

    Science.gov (United States)

    Tabrizi, Jafar-Sadegh; Farahbakhsh, Mostafa; Shahgoli, Javad; Rahbar, Mohammad Reza; Naghavi-Behzad, Mohammad; Ahadi, Hamid-Reza; Azami-Aghdash, Saber

    2015-10-01

    Excellence and quality models are comprehensive methods for improving the quality of healthcare. The aim of this study was to design excellence and quality model for training centers of primary health care using Delphi method. In this study, Delphi method was used. First, comprehensive information were collected using literature review. In extracted references, 39 models were identified from 34 countries and related sub-criteria and standards were extracted from 34 models (from primary 39 models). Then primary pattern including 8 criteria, 55 sub-criteria, and 236 standards was developed as a Delphi questionnaire and evaluated in four stages by 9 specialists of health care system in Tabriz and 50 specialists from all around the country. Designed primary model (8 criteria, 55 sub-criteria, and 236 standards) were concluded with 8 criteria, 45 sub-criteria, and 192 standards after 4 stages of evaluations by specialists. Major criteria of the model are leadership, strategic and operational planning, resource management, information analysis, human resources management, process management, costumer results, and functional results, where the top score was assigned as 1000 by specialists. Functional results had the maximum score of 195 whereas planning had the minimum score of 60. Furthermore the most and the least sub-criteria was for leadership with 10 sub-criteria and strategic planning with 3 sub-criteria, respectively. The model that introduced in this research has been designed following 34 reference models of the world. This model could provide a proper frame for managers of health system in improving quality.

  20. From representing to modelling knowledge: Proposing a two-step training for excellence in concept mapping

    Directory of Open Access Journals (Sweden)

    Joana G. Aguiar

    2017-09-01

    Full Text Available Training users in the concept mapping technique is critical for ensuring a high-quality concept map in terms of graphical structure and content accuracy. However, assessing excellence in concept mapping through structural and content features is a complex task. This paper proposes a two-step sequential training in concept mapping. The first step requires the fulfilment of low-order cognitive objectives (remember, understand and apply to facilitate novices’ development into good Cmappers by honing their knowledge representation skills. The second step requires the fulfilment of high-order cognitive objectives (analyse, evaluate and create to grow good Cmappers into excellent ones through the development of knowledge modelling skills. Based on Bloom’s revised taxonomy and cognitive load theory, this paper presents theoretical accounts to (1 identify the criteria distinguishing good and excellent concept maps, (2 inform instructional tasks for concept map elaboration and (3 propose a prototype for training users on concept mapping combining online and face-to-face activities. The proposed training application and the institutional certification are the next steps for the mature use of concept maps for educational as well as business purposes.

  1. Improving Conceptual Understanding and Representation Skills Through Excel-Based Modeling

    Science.gov (United States)

    Malone, Kathy L.; Schunn, Christian D.; Schuchardt, Anita M.

    2018-02-01

    The National Research Council framework for science education and the Next Generation Science Standards have developed a need for additional research and development of curricula that is both technologically model-based and includes engineering practices. This is especially the case for biology education. This paper describes a quasi-experimental design study to test the effectiveness of a model-based curriculum focused on the concepts of natural selection and population ecology that makes use of Excel modeling tools (Modeling Instruction in Biology with Excel, MBI-E). The curriculum revolves around the bio-engineering practice of controlling an invasive species. The study takes place in the Midwest within ten high schools teaching a regular-level introductory biology class. A post-test was designed that targeted a number of common misconceptions in both concept areas as well as representational usage. The results of a post-test demonstrate that the MBI-E students significantly outperformed the traditional classes in both natural selection and population ecology concepts, thus overcoming a number of misconceptions. In addition, implementing students made use of more multiple representations as well as demonstrating greater fascination for science.

  2. A Model of Tourism Destination Competitiveness: The case of the Italian Destinations of Excellence

    Directory of Open Access Journals (Sweden)

    Gianluca Goffi

    2013-11-01

    Full Text Available Tourism worldwide is becoming increasingly competitive. Competitiveness has been associated in the tourism literature as a critical element for the success of tourism destinations. Particular emphasis is placed on identifying and analyzing the various factors that influence the competitiveness of tourism destinations. The paper extends the Richie & Crouch (2000 model and develops a set of indicators that considers the different issues concerning tourism competitiveness. The indicators are focused on the various dimensions of sustainability. The paper offers insights into the model, each determinant has been extensively described. The aim of the paper is to test whether and to what extent the current set of indicators integrated into the present model can help explaining the competitiveness of a tourism destination. The model is tested on a unique dataset of 610 Italian Destinations of Excellence. Principal Component Analysis is applied on the responses to the items measuring destination competitiveness.

  3. An Organizational Model for Excellence in Healthcare Delivery: Evidence From Winners of the Baldrige Quality Award.

    Science.gov (United States)

    Griffith, John R

    Winners of the Baldrige National Quality Award in healthcare have documented top quartile clinical outcomes and patient satisfaction across a variety of American communities and a full spectrum of care. Their results also show high levels of satisfaction among physicians, nurses, and other workers, as well as effective financial performance. The managerial methods they use-collectively, the Baldrige model-are consistent with organizational theory literature and are found across all winners. The winners have sustained excellence after winning and expanded it by acquisition of other healthcare organizations.The model differs substantially from traditional management approaches in healthcare delivery. It is a comprehensive program that emphasizes a shared focus on excellence, systematically responsive management, evidence-based medicine, multidimensional measures and negotiated goals, improvement of work processes, thorough training, and extensive rewards. The model could be expanded on a much larger scale. Doing so successfully would substantially improve the quality and cost of healthcare, as well as the satisfaction and commitment of care providers and other staff. The opportunity deserves further study and trial by large healthcare delivery systems, insurers, and consulting companies.

  4. The European Foundation for Quality Management (EFQM Excellence Model in a Low Voltage Switchgear Compan

    Directory of Open Access Journals (Sweden)

    Özgür Özmen

    2017-11-01

    Full Text Available The Turkish low voltage switchgear sector is made up of several local and international companies. Generally, local companies operating in this sector try to get a competitive advantage by fabricating cheap products, in order to cope with the competition that focuses more on quality. What’s more, international corporations perform quality activities under the organization and control of their top-managements from abroad. Although VIKO is a local producer, it is a company willing to invest more in quality, as well as in research and development. VIKO company is the focus of this self-assessment study, since it lies at the conjunction of companies operating in this sector, it being a local company performing various quality enhancement activities. Simultaneously, the authors consider that this study shall prove useful to create an overview over the entire Turkish low voltage switchgear sector. The evaluation of the company and its core-activities was based upon nine criteria of the European Foundation for Quality Management (EFQM Excellence Model, in order to identify the strengths, the weaknesses and aspects that require improvements. This is the first study worldwide performed in the low voltage switchgear sector and it is aimed at motivating other Turkish companies that operate in this sector to implement The European Foundation for Quality Management (EFQM Excellence Model in their TQM activities (Total Quality Management.

  5. Strategies for Excellence: Recommendations for a Productive School Model with Strategies for Achieving the Model. The Final Report of the IASB Committee on Strategies for Excellence.

    Science.gov (United States)

    Iowa Association of School Boards, Des Moines.

    The charge of the Committee on Strategies for Excellence was to examine the current status of elementary and secondary education in Iowa, and to investigate ways in which school districts could be educationally more productive. The report brings together recommendations from various state and national reports, reviews the literature, and makes…

  6. Promoting excellence in end-of-life care: a report on innovative models of palliative care.

    Science.gov (United States)

    Byock, Ira; Twohig, Jeanne Sheils; Merriman, Melanie; Collins, Karyn

    2006-02-01

    Promoting Excellence in End-of Life Care, a national program of The Robert Wood Johnson Foundation, funded 22 demonstration projects representing a wide range of health care settings and patient populations to develop innovative models for delivering palliative care that addressed documented deficiencies in the care of patients and families facing the final stage of life. To determine the practicality (feasibility of development and operation as well as acceptance by stakeholders) of new models of care and to determine the impact of the models on access to, quality of and financing for palliative care. The program cannot report scientifically rigorous outcomes, but the grant-funded projects used a variety of methods and measures to assess acceptance of new models and their impact from the perspectives of various stakeholders, including patients and their families, clinicians, administrators and payers. While it is not possible to aggregate data across projects, the data reported to the Promoting Excellence national program office were used to describe program impact with respect to the practicality of palliative care service integration into existing clinical care settings (feasibility and acceptance by stakeholders), the availability and use of palliative care services (access), quality of care (conformance to patient expectations and accepted clinical standards) and costs of care. The 22 projects provided services in urban as well as rural settings, in integrated health systems, hospitals, outpatient clinics, cancer centers, nursing homes, renal dialysis clinics, inner city public health and safety net systems and prisons. Populations served included prison inmates, military veterans, renal dialysis patients, Native Americans, Native Alaskans, and African American patients, inner-city medically underserved patients, pediatric patients, and persons with serious mental illness patients. Hosting or adopting institutions sustained or expanded twenty of the 22 models

  7. Visual Basic, Excel-based fish population modeling tool - The pallid sturgeon example

    Science.gov (United States)

    Moran, Edward H.; Wildhaber, Mark L.; Green, Nicholas S.; Albers, Janice L.

    2016-02-10

    The model presented in this report is a spreadsheet-based model using Visual Basic for Applications within Microsoft Excel (http://dx.doi.org/10.5066/F7057D0Z) prepared in cooperation with the U.S. Army Corps of Engineers and U.S. Fish and Wildlife Service. It uses the same model structure and, initially, parameters as used by Wildhaber and others (2015) for pallid sturgeon. The difference between the model structure used for this report and that used by Wildhaber and others (2015) is that variance is not partitioned. For the model of this report, all variance is applied at the iteration and time-step levels of the model. Wildhaber and others (2015) partition variance into parameter variance (uncertainty about the value of a parameter itself) applied at the iteration level and temporal variance (uncertainty caused by random environmental fluctuations with time) applied at the time-step level. They included implicit individual variance (uncertainty caused by differences between individuals) within the time-step level.The interface developed for the model of this report is designed to allow the user the flexibility to change population model structure and parameter values and uncertainty separately for every component of the model. This flexibility makes the modeling tool potentially applicable to any fish species; however, the flexibility inherent in this modeling tool makes it possible for the user to obtain spurious outputs. The value and reliability of the model outputs are only as good as the model inputs. Using this modeling tool with improper or inaccurate parameter values, or for species for which the structure of the model is inappropriate, could lead to untenable management decisions. By facilitating fish population modeling, this modeling tool allows the user to evaluate a range of management options and implications. The goal of this modeling tool is to be a user-friendly modeling tool for developing fish population models useful to natural resource

  8. Development of the ECLSS Sizing Analysis Tool and ARS Mass Balance Model Using Microsoft Excel

    Science.gov (United States)

    McGlothlin, E. P.; Yeh, H. Y.; Lin, C. H.

    1999-01-01

    The development of a Microsoft Excel-compatible Environmental Control and Life Support System (ECLSS) sizing analysis "tool" for conceptual design of Mars human exploration missions makes it possible for a user to choose a certain technology in the corresponding subsystem. This tool estimates the mass, volume, and power requirements of every technology in a subsystem and the system as a whole. Furthermore, to verify that a design sized by the ECLSS Sizing Tool meets the mission requirements and integrates properly, mass balance models that solve for component throughputs of such ECLSS systems as the Water Recovery System (WRS) and Air Revitalization System (ARS) must be developed. The ARS Mass Balance Model will be discussed in this paper.

  9. Business performance assessment and the EFQM Excellence Model 2010 (case study

    Directory of Open Access Journals (Sweden)

    Mária Antošová

    2015-01-01

    Full Text Available The application of the latest management methods becomes today, during the ongoing European integration processes, a requisite for the success of the business within the environment of international markets. In this paper, the authors pay attention to the expansion of the organizational knowledge base with an application of a new management method. They are dealing with assessment of the organization performance, the issue of its effectiveness and the increasing economic efficiency, on an example of a selected mining company as a case study. In order to detect weaknesses in the company reviewed and to offer suggestions for improvement, which may move the company towards prosperity, the authors carried out the performance assessment by using the EFQM Excellence Model 2010. The aim of this paper is to introduce the business performance assessment model in terms of the European standards that will allow the use of latest management methods in the environment of both the Slovak and European companies.

  10. Method and Excel VBA Algorithm for Modeling Master Recession Curve Using Trigonometry Approach.

    Science.gov (United States)

    Posavec, Kristijan; Giacopetti, Marco; Materazzi, Marco; Birk, Steffen

    2017-11-01

    A new method was developed and implemented into an Excel Visual Basic for Applications (VBAs) algorithm utilizing trigonometry laws in an innovative way to overlap recession segments of time series and create master recession curves (MRCs). Based on a trigonometry approach, the algorithm horizontally translates succeeding recession segments of time series, placing their vertex, that is, the highest recorded value of each recession segment, directly onto the appropriate connection line defined by measurement points of a preceding recession segment. The new method and algorithm continues the development of methods and algorithms for the generation of MRC, where the first published method was based on a multiple linear/nonlinear regression model approach (Posavec et al. 2006). The newly developed trigonometry-based method was tested on real case study examples and compared with the previously published multiple linear/nonlinear regression model-based method. The results show that in some cases, that is, for some time series, the trigonometry-based method creates narrower overlaps of the recession segments, resulting in higher coefficients of determination R 2 , while in other cases the multiple linear/nonlinear regression model-based method remains superior. The Excel VBA algorithm for modeling MRC using the trigonometry approach is implemented into a spreadsheet tool (MRCTools v3.0 written by and available from Kristijan Posavec, Zagreb, Croatia) containing the previously published VBA algorithms for MRC generation and separation. All algorithms within the MRCTools v3.0 are open access and available free of charge, supporting the idea of running science on available, open, and free of charge software. © 2017, National Ground Water Association.

  11. The chick eye in vision research: An excellent model for the study of ocular disease.

    Science.gov (United States)

    Wisely, C Ellis; Sayed, Javed A; Tamez, Heather; Zelinka, Chris; Abdel-Rahman, Mohamed H; Fischer, Andy J; Cebulla, Colleen M

    2017-11-01

    The domestic chicken, Gallus gallus, serves as an excellent model for the study of a wide range of ocular diseases and conditions. The purpose of this manuscript is to outline some anatomic, physiologic, and genetic features of this organism as a robust animal model for vision research, particularly for modeling human retinal disease. Advantages include a sequenced genome, a large eye, relative ease of handling and maintenance, and ready availability. Relevant similarities and differences to humans are highlighted for ocular structures as well as for general physiologic processes. Current research applications for various ocular diseases and conditions, including ocular imaging with spectral domain optical coherence tomography, are discussed. Several genetic and non-genetic ocular disease models are outlined, including for pathologic myopia, keratoconus, glaucoma, retinal detachment, retinal degeneration, ocular albinism, and ocular tumors. Finally, the use of stem cell technology to study the repair of damaged tissues in the chick eye is discussed. Overall, the chick model provides opportunities for high-throughput translational studies to more effectively prevent or treat blinding ocular diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Nutrient modeling for a semi-intensive IMC pond: an MS-Excel approach.

    Science.gov (United States)

    Ray, Lala I P; Mal, B C; Moulick, S

    2017-11-01

    Semi-intensive Indian Major Carp (IMC) culture was practised in polythene lined dugout ponds at the Aquacultural Farm of Indian Institute of Technology, Kharagpur, West Bengal for 3 consecutive years at three different stocking densities (S.D), viz., 20,000, 35,000 and 50,000 numbers of fingerlings per hectare of water spread area. Fingerlings of Catla, Rohu and Mrigal were raised at a stocking ratio of 4:3:3. Total ammonia nitrogen (TAN) value along with other fishpond water quality parameters was monitored at 1 day intervals to ensure a good water ecosystem for a better fish growth. Water exchange was carried out before the TAN reached the critical limit. Field data on TAN obtained from the cultured fishponds stocked with three different stocking densities were used to study the dynamics of TAN. A developed model used to study the nutrient dynamics in shrimp pond was used to validate the observed data in the IMC pond ecosystem. Two years of observed TAN data were used to calibrate the spreadsheet model and the same model was validated using the third year observed data. The manual calibration based on the trial and error process of parameters adjustments was used and several simulations were performed by changing the model parameters. After adjustment of each parameter, the simulated and measured values of the water quality parameters were compared to judge the improvement in the model prediction. Forward finite difference discretization method was used in a MS-Excel spreadsheet to calibrate and validate the model for obtaining the TAN levels during the culture period. Observed data from the cultured fishponds of three different S.D were used to standardize 13 model parameters. The efficiency of the developed spreadsheet model was found to be more than 90% for the TAN estimation in the IMC cultured fishponds.

  13. Performance Evaluation of Sadoghi Hospital Based on «EFQM» Organizational Excellence Model

    Directory of Open Access Journals (Sweden)

    A Sanayeei

    2013-04-01

    Full Text Available Introduction: Realm of health care that organizations have faced in recent years has been described with high level of dynamism and development. To survive in such conditions, performance evaluation can have an effective role in satisfying proper quality for services. This study aimed to evaluate the performance of Shahid Sadoghi Yazd hospital through EFQM approach. Methods: This was a descriptive cross-sectional study. Data collection instrument was EFQM organization Excellence Model questionnaire which was completed by all the managers. The research data was gathered from a sample of 302 patients, staff, personnel and medical staff working in different parts of the hospital. Random stratified samples were selected and descriptive statistics were utilized in order to analyze the data. Results: The results revealed that Shahid Sadoughi hospital acquired 185.41 points out of the total 500 points considered in the model EFQM. In other words, the rating reflects the fact that regarding the defined desired position, the hospital has not achieved the desired rating. Conclusion: Since the hospital performance is posited in a low-middle class, much more attention is required in regard to therapeutic management in this hospital. Therefore, codifying an efficient and effective program to improve the hospital performance is necessary. Furthermore, it seems that EFQM model can be considered as a comprehensive model for performance evaluation in hospitals.

  14. Trends in Education Excellence Gaps: A 12-Year International Perspective via the Multilevel Model for Change

    Science.gov (United States)

    Rutkowski, David; Rutkowski, Leslie; Plucker, Jonathan A.

    2012-01-01

    A recent study in the USA documented the existence and growth of "excellence gaps" among students. These gaps are similar to the minimum competency achievement gaps that proliferate in policy discussions in many Western countries, but excellence gaps focus on the highest level of achievement rather than minimum competency. We extend this…

  15. Level of quality management in the Municipal Sports Services, contrast trough EFQM Excellence Model.

    Science.gov (United States)

    Martínez-Moreno, Alfonso; Díaz Suárez, Arturo

    2016-01-01

    The quality management in the Municipal Sports Services is embedded in the servuction provided to the citizens, which are their internal customers who determine the quality improvement ensuring competitiveness with excellence criteria. The Model of the European Foundation for Quality Management enables the evaluation of organization progress towards achieving quality goals, from a structured, measurable and comparable methodology. The aim is to carry out a diagnosis of the level of implementation of quality in the Municipal Sports Services of the Region of Murcia, Spain. The sample of 287 workers of 30 sports services gets a high level of reliability at all scales, with a coefficient of variation of .985 (range .810-.943). The score in the criteria of Policy and Strategy, People Management, Alliances and Resources, Processes and People Results were significantly higher (p < .05) in the Municipalities with more than 25,000 inhabitants when compared with those less than 10,000 and with those from 10,000 to 25,000 inhabitants obtaining global ratings of 571 points, those less than 10,000, 590 points those from 10,000 to 25,000 and those higher than 25,000 reach 636, having a good level of quality in relation to the scale that determines the model.

  16. Excellent approach to modeling urban expansion by fuzzy cellular automata: agent base model

    Science.gov (United States)

    Khajavigodellou, Yousef; Alesheikh, Ali A.; Mohammed, Abdulrazak A. S.; Chapi, Kamran

    2014-09-01

    Recently, the interaction between humans and their environment is the one of important challenges in the world. Landuse/ cover change (LUCC) is a complex process that includes actors and factors at different social and spatial levels. The complexity and dynamics of urban systems make the applicable practice of urban modeling very difficult. With the increased computational power and the greater availability of spatial data, micro-simulation such as the agent based and cellular automata simulation methods, has been developed by geographers, planners, and scholars, and it has shown great potential for representing and simulating the complexity of the dynamic processes involved in urban growth and land use change. This paper presents Fuzzy Cellular Automata in Geospatial Information System and remote Sensing to simulated and predicted urban expansion pattern. These FCA-based dynamic spatial urban models provide an improved ability to forecast and assess future urban growth and to create planning scenarios, allowing us to explore the potential impacts of simulations that correspond to urban planning and management policies. A fuzzy inference guided cellular automata approach. Semantic or linguistic knowledge on Land use change is expressed as fuzzy rules, based on which fuzzy inference is applied to determine the urban development potential for each pixel. The model integrates an ABM (agent-based model) and FCA (Fuzzy Cellular Automata) to investigate a complex decision-making process and future urban dynamic processes. Based on this model rapid development and green land protection under the influences of the behaviors and decision modes of regional authority agents, real estate developer agents, resident agents and non- resident agents and their interactions have been applied to predict the future development patterns of the Erbil metropolitan region.

  17. From research excellence to brand relevance: A model for higher education reputation building

    Directory of Open Access Journals (Sweden)

    Nina Overton-de Klerk

    2016-05-01

    Full Text Available In this article we propose a novel approach to reputation development at higher education institutions. Global reputation development at higher education institutions is largely driven by research excellence, is predominantly measured by research output, and is predominantly reflected in hierarchical university rankings. The ranking becomes equated with brand equity. We argue that the current approach to reputation development in higher education institutions is modernist and linear. This is strangely out-of-kilter with the complexities of a transforming society in flux, the demands of a diversity of stakeholders, and the drive towards transdisciplinarity, laterality, reflexivity and relevance in science. Good research clearly remains an important ingredient of a university's brand value. However, a case can be made for brand relevance, co-created in collaboration with stakeholders, as an alternative and non-linear way of differentiation. This approach is appropriate in light of challenges in strategic science globally as well as trends and shifts in the emerging paradigm of strategic communication. In applying strategic communication principles to current trends and issues in strategic science and the communication thereof, an alternative model for strategic reputation building at higher education institutions is developed.

  18. Conceptualizing strategic business model innovation leadership for business survival and business model innovation excellence

    DEFF Research Database (Denmark)

    Lindgren, Peter; Abdullah, Maizura Ailin

    2013-01-01

    Too many businesses are being marginalized by blind "business model innovations (BMIs)" and simple "BMIs". As documented in previous research (Markides 2008, Lindgren 2012), most businesses perform BMIs at a reactive level i.e. perceiving what the market, customers and network partners might want...... rather than what they actually demand. Few businesses have the ability to proactively lead BMIs and on a strategic level lead BMIs to something that fits the business’s long term perspective (Hamel 2011). Apple, Ryanair, Facebook, Zappo are some businesses that have shown BMI Leadership (BMIL......) in a proactive way - and more importantly, as some examples of first level BMIL. The overall aim of the BMIL is to prevent businesses from being marginalized by the BMI and thereby to optimize the business’s total BMI investment. The literature research and case research we studied gave us some important...

  19. Redesigning Schools to Reach Every Student with Excellent Teachers: Financial Planning for Time-Technology Swap--Rotation Model

    Science.gov (United States)

    Public Impact, 2012

    2012-01-01

    This brief shows how teachers in a Time-Technology swap school model may earn more, sustainably. In this model, schools use age-appropriate portions of digital learning (as little as about an hour daily per student) to free the time of excellent teachers to teach more students and potentially to collaborate with peers. By teaching more students,…

  20. Collaborative Workshops and Student Academic Performance in Introductory College Mathematics Courses: A Study of a Treisman Model Math Excel Program.

    Science.gov (United States)

    Duncan, Hollis; Dick, Thomas

    2000-01-01

    Describes the Treisman model which involves supplemental workshops in which college students solve problems in collaborative learning groups. Reports on the effectiveness of Math Excel, an implementation of the Treisman model for introductory mathematics courses at Oregon State University over five academic terms. Reveals a significant effect on…

  1. Why Excel?

    Science.gov (United States)

    Barreto, Humberto

    2015-01-01

    This article is not the usual Excel pedagogy fare in that it does not provide an application or example taught via a spreadsheet. Instead, it briefly reviews the history of spreadsheets in the economics classroom and explores the current environment, with an emphasis on modern learning theory. The conclusion is not surprising: spreadsheets improve…

  2. Sourcing Excellence

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi

    2011-01-01

    Sourcing Excellence is one of the key performance indicators (KPIs) in this world of ever changing sourcing strategies. Manufacturing companies need to access and diagnose the reliability and competencies of existing suppliers in order to coordinate and develop them. This would help in managing...

  3. Project Excel: A Model for an Individually Focused Staff Development Program.

    Science.gov (United States)

    Minix, Nancy A.; Pearce, Winston Thomas

    A description is given of the development and implementation of an inservice program, "Project Excel," which was designed in accordance with andragogical theory. This theory is based upon four major assumptions: (1) as people grow, they become increasingly self-directed; (2) as people grow, a reservoir of experiences which provide a…

  4. Par Pond water balance

    International Nuclear Information System (INIS)

    Hiergesell, R.A.; Dixon, K.L.

    1996-06-01

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  5. ETV TEST REPORT OF CONTROL OF BIOAEROSOLS IN HVAC SYSTEMS GLASFLOSS INDUSTRIES EXCEL FILTER, MODEL SBG24242898

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the Excel Filter, Model SBG24242898 air filter for dust and bioaerosol filtration manufactured by Glasfloss Industries, Inc. The pressure drop across the filter was 82 Pa clean and 348 Pa...

  6. Design and explanation of organizational excellence model in home appliances industry

    Directory of Open Access Journals (Sweden)

    Seyed Abbas Kazemi

    2012-01-01

    Full Text Available Home appliances are considered as one of low margin and competitive industry in the world. This industry often needs significant amount of investment and resources and it often faces with some challenges during economic crises. In this paper, we present a framework for organizational excellence to detect any possible problems in home appliances industry. The proposed framework of this paper is used for a real-world case study of Iranian home appliances. The results of our survey indicate that there are four major dimensions involved with this industry including facilities, knowledge and skills, environment and vision. There are three criteria associated with facilities with 30 indexes, 14 criteria associated with knowledge and skills with 144 indexes, three criteria involved with environment with 33 indexes and five criteria linked with vision with 53 indexes. Therefore, home appliances in our case study needs 4 dimensions for achieving the organizational excellence.

  7. Improving National Water Modeling: An Intercomparison of two High-Resolution, Continental Scale Models, CONUS-ParFlow and the National Water Model

    Science.gov (United States)

    Tijerina, D.; Gochis, D.; Condon, L. E.; Maxwell, R. M.

    2017-12-01

    Development of integrated hydrology modeling systems that couple atmospheric, land surface, and subsurface flow is growing trend in hydrologic modeling. Using an integrated modeling framework, subsurface hydrologic processes, such as lateral flow and soil moisture redistribution, are represented in a single cohesive framework with surface processes like overland flow and evapotranspiration. There is a need for these more intricate models in comprehensive hydrologic forecasting and water management over large spatial areas, specifically the Continental US (CONUS). Currently, two high-resolution, coupled hydrologic modeling applications have been developed for this domain: CONUS-ParFlow built using the integrated hydrologic model ParFlow and the National Water Model that uses the NCAR Weather Research and Forecasting hydrological extension package (WRF-Hydro). Both ParFlow and WRF-Hydro include land surface models, overland flow, and take advantage of parallelization and high-performance computing (HPC) capabilities; however, they have different approaches to overland subsurface flow and groundwater-surface water interactions. Accurately representing large domains remains a challenge considering the difficult task of representing complex hydrologic processes, computational expense, and extensive data needs; both models have accomplished this, but have differences in approach and continue to be difficult to validate. A further exploration of effective methodology to accurately represent large-scale hydrology with integrated models is needed to advance this growing field. Here we compare the outputs of CONUS-ParFlow and the National Water Model to each other and with observations to study the performance of hyper-resolution models over large domains. Models were compared over a range of scales for major watersheds within the CONUS with a specific focus on the Mississippi, Ohio, and Colorado River basins. We use a novel set of approaches and analysis for this comparison

  8. A Conceptual Model of Excellent Performance Mode of Port Enterprise Logistics Management

    Directory of Open Access Journals (Sweden)

    Jiang He

    2017-11-01

    Full Text Available Port as one of the key hubs of international logistics, which has become the main part and the base of global logistics management. The port enterprises, plays an important role in the global supply chain. However, due to the lack of understanding in port supply chain management, coordination between the port enterprises, the integration of business process is not perfect, the lack of information sharing between various organizations, ports enterprises usually failed to fully play its positive role. Based on this, the paper makes the port enterprises as the research object, and introduces the excellent performance mode into the port enterprises. In order to study the port enterprises how to carry out effective quality management, and formation the coordination and integration of upstream and downstream of enterprises, so as to realize the competitive advantage in port logistics.

  9. Method for Modeling High-Temporal-Resolution Stream Inflows in a Long-Term ParFlow.CLM Simulation

    Science.gov (United States)

    Miller, G. R.; Merket, C.

    2017-12-01

    Traditional hydrologic modeling has compartmentalized the water cycle into distinct components (e.g. rainfall-runoff, river routing, or groundwater flow models). An integrated, process-based modeling framework assesses two or more of these components simultaneously, reducing the error associated with approximated boundary conditions. One integrated model, ParFlow.CLM, offers the advantage of parallel computing, but it lacks any mechanism for incorporating time-varying streamflow as an upstream boundary condition. Here, we present a generalized method for applying transient streamflow at an upstream boundary in ParFlow.CLM. Downstream flow values are compared to predictions by traditional runoff and routing methods as implemented in HEC-HMS. Additionally, we define a model spin-up process which includes initialization of steady-state streamflow. The upstream inflow method was successfully tested on two domains - one synthetic tilted V catchment and an idealized small stream catchment in the Brazos River Basin. The stream in the idealized domain is gaged at the upstream and downstream boundaries. Both tests assumed a homogeneous subsurface so that the efficacy of the transient streamflow method could be evaluated with minimal complications by groundwater interactions. In the tilted V catchment, spin-up criteria were achieved within 6 model years. A 25 x 25 x 66 cell model grid was run at a computational efficiency of values early in the simulation.

  10. Native excellence

    International Nuclear Information System (INIS)

    Bower, T.

    1992-01-01

    Syncrude Canada Ltd., operator of the oil sands mine and processing plant near Fort McMurray, Alberta, produces 11% of Canada's crude oil and is the country's largest private-sector employer of native Canadians. Syncrude has the goal of employing about 10% native Canadians, which is about the percentage of natives in the regional population. Examples are presented of successful native employment and entrepreneurship at Syncrude. Doreen Janvier, once employed at Syncrude's mine wash bays, was challenged to form her own company to contract out labor services. Her company, DJM Enterprises, now has a 2-year contract to operate three highly sophisticated wash bays used to clean mining equipment, and is looking to bid on other labor contracts. Mabel Laviolette serves as liaison between the oil containment and recovery team, who recover oil skimmed off Syncrude's tailings basin, and the area manager. The team approach and the seasonal nature of the employment fit in well with native cultural patterns. The excellence of native teamwork is also illustrated in the mine rescue team, one unit of which is entirely native Canadian. Part of Syncrude's aboriginal policy is to encourage development of aboriginal enterprises, such as native-owned Clearwater Welding and Fabricating Ltd., which has held welding and fabricating contracts with most major companies in the region and is a major supplier of skilled tradesmen to Syncrude. Syncrude also provides employment and training, encourages natives to continue their education, and promotes local community development. 4 figs

  11. Passing excellence

    Science.gov (United States)

    Tsoupikova, Daria

    2007-02-01

    This paper describes the research and development of a virtual reality visualization project "Passing excellence" about the world famous architectural ensemble "Kizhi". The Kizhi Pogost is located on an island in Lake Onega in northern Karelia in Russia. It is an authentic museum of an ancient wood building tradition which presents a unique artistic achievement. This ensemble preserves a concentration of masterpieces of the Russian heritage and is included in the List of Most Endangered Sites of the World Monuments Watch protected by World Heritage List of UNESCO. The project strives to create a unique virtual observation of the dynamics of the architectural changes of the museum area beginning from the 15th Century up to the 21st Century. The visualization is being created to restore the original architecture of Kizhi island based on the detailed photographs, architectural and geometric measurements, textural data, video surveys and resources from the Kizhi State Open-Air Museum archives. The project is being developed using Electro, an application development environment for the tiled display high-resolution graphics visualization system and can be shown on the virtual reality systems such as the GeoWall TM and the C-Wall.

  12. Towards a multi-stakeholder-driven model for excellence in higher ...

    African Journals Online (AJOL)

    The model is further based on significant NQF and OBE alignment of all learning ... form the foundation of this strategic-driven model for curriculum development. ... of quality planning, quality management system implementation and quality

  13. From the model of integral attention to the creation of centers of excellence in rheumatoid arthritis.

    Science.gov (United States)

    Santos-Moreno, Pedro; Castañeda, Oswaldo; Garro, Boris; Flores, Dennis; Sánchez, Guillermo; Castro, Carlos

    2015-03-01

    For the Pan American Health Organization (PAHO), the care of patients with chronic diseases currently experiences fragmentation in attention, generating poor performance of health services. Thus, comprehensive health care strategies arise to mitigate these problems; one of them are Centers of Excellence (CoEs), which aim to obtain high quality results in health from the adequate and minimum use of resources. The objective of this study was to describe the history and current context of the CoE in comprehensive care in patients with rheumatoid arthritis (RA). A systematic search of the literature terms (MeSH) was performed. The bases used were PubMed, Ebsco Host, Lilacs, Science Direct, Ovid, and Google (gray literature). The source of the information was evaluated to determine its quality. International standards focus the CoEs starting from comprehensive management of patients with RA and patient volume, continuous improvement, and quality of health care, constituting an interdisciplinary team. The REAL-PANLAR group suggested that the inclusion of the strategy "Treat to Target", and patient education improves patient conditions and understanding of the disease. RA is a prevalent and costly disease. The creation of comprehensive care centers of the CoE type is an initiative that improves the prognosis of RA. This document aims to encourage rheumatologists and scientific societies to structure CoE in an interdisciplinary endeavor.

  14. An exercise to teach quantitative analysis and modeling using Excel-based analysis of the carbon cycle in the anthropocene

    Science.gov (United States)

    Stoll, Heather

    2013-04-01

    A computer modeling exercise was created to allows students to investigate the consequences of fossil fuel burning and land use change on the amount of carbon dioxide in the atmosphere. Students work with a simple numerical model of the carbon cycle which is rendered in Excel, and conduct a set of different sensitivity tests with different amounts and rate of C additions, and then graph and discuss their results. In the recommended approach, the model is provided to students without the biosphere and in class the formulas to integrate this module are typed into Excel simultaneously by instructor and students, helping students understand how the larger model is set up. In terms of content, students learn to recognize the redistribution of fossil fuel carbon between the ocean and atmosphere, and distinguish the consequences of rapid vs slow rates of addition of fossil fuel CO2 and the reasons for this difference. Students become familiar with the use of formulas in Excel and working with a large (300 rows, 20 columns) worksheet and gain competence in graphical representation of multiple scenarios. Students learn to appreciate the power and limitations of numerical models of complex cycles, the concept of inverse and forward models, and sensitivity tests. Finally, students learn that a reasonable hypothesis, may be "reasonable" but still not quantitatively sufficient - in this case, that the "Industrial Revolution" was not the source of increasing atmospheric CO2 from 1750-1900. The described activity is available to educators on the Teach the Earth portal of the Science Education Research Center (SERC) http://serc.carleton.edu/quantskills/activities/68751.html.

  15. Parameter estimation of variable-parameter nonlinear Muskingum model using excel solver

    Science.gov (United States)

    Kang, Ling; Zhou, Liwei

    2018-02-01

    Abstract . The Muskingum model is an effective flood routing technology in hydrology and water resources Engineering. With the development of optimization technology, more and more variable-parameter Muskingum models were presented to improve effectiveness of the Muskingum model in recent decades. A variable-parameter nonlinear Muskingum model (NVPNLMM) was proposed in this paper. According to the results of two real and frequently-used case studies by various models, the NVPNLMM could obtain better values of evaluation criteria, which are used to describe the superiority of the estimated outflows and compare the accuracies of flood routing using various models, and the optimal estimated outflows by the NVPNLMM were closer to the observed outflows than the ones by other models.

  16. Handling of computational in vitro/in vivo correlation problems by Microsoft Excel: V. Predictive absorbability models.

    Science.gov (United States)

    Langenbucher, Frieder

    2007-08-01

    This paper discusses Excel applications related to the prediction of drug absorbability from physicochemical constants. PHDISSOC provides a generalized model for pH profiles of electrolytic dissociation, water solubility, and partition coefficient. SKMODEL predicts drug absorbability, based on a log-log plot of water solubility and O/W partitioning; augmented by additional features such as electrolytic dissociation, melting point, and the dose administered. GIABS presents a mechanistic model of g.i. drug absorption. BIODATCO presents a database compiling relevant drug data to be used for quantitative predictions.

  17. Measures and modelling of PAR (photosynthetically-active radiation) for the Northeast of Brazil; Medidas e modelagem da radiacao PAR (photosynthetically-active radiation) para o nordeste do Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Tiba, Chigueru; Leal, Sergio da S.A. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear], e-mail: tiba@rce.neoline.com.br

    2004-07-01

    Photosynthetically active solar radiation, known by its acronym in the English language as PAR, is the principal driving force of innumerable biological and physical processes related to biomass production, such as, the evolution of vegetal covering, agricultural productivity, and countless environment aspects, among others. Unfortunately in Brazil and particularly in the Northeast of Brazil, the PAR radiation measures are not a routine part of meteorological station measures, and therefore are still rarer than solar irradiation measures. In this context, a station was installed in Recife, Pernambuco in 2003, to carry out simultaneous measures of daily solar irradiation and PAR irradiation, which permits the modelling and valuation of the relationship between these two parameters and thus makes the estimation of PAR radiation possible, where there used to be only information on solar irradiation. Three others stations are being installed, one on Fernando de Noronha-PE, another in Pesqueira-PE, and the other in Xingo-SE, which complete a group of 4 between Latitudes 8 deg and 10 deg South and Longitudes 34 deg to 38 deg West, each having differentiated Equatorial Climates: island maritime, continental maritime, sylvan (Agreste) and semi-arid. (author)

  18. Development and implementation of the South African construction excellence model (SACEM)

    CSIR Research Space (South Africa)

    Dlungwana, WS

    2002-04-01

    Full Text Available The focus of the paper i on the current progress of a research project of the Council for Scientific and Industrial Research's (CSIR) Division of Building and Construction Technology in developing a performance assessment model for contractors...

  19. INTRODUCING A CAUSAL PAR( p MODEL TO EVALUATE THE INFLUENCE OF CLIMATE VARIABLES IN RESERVOIR INFLOWS: A BRAZILIAN CASE

    Directory of Open Access Journals (Sweden)

    Paula Medina Maçaira

    Full Text Available ABSTRACT The Brazilian electricity energy matrix is essentially formed by hydraulic sources which currently account for 70% of the installed capacity. One of the most important characteristics of a generation system with hydro predominance is the strong dependence on the inflow regimes. Nowadays, the Brazilian power sector uses the PAR(p model to generate scenarios for hydrological inflows. This approach does not consider any exogenous information that may affect hydrological regimes. The main objective of this paper is to infer on the influence of climatic events in water inflows as a way to improve the model’s performance. The proposed model is called “causal PAR(p” and considers exogenous variables, such as El Niño and Sunspots, to generate scenarios for some Brazilian reservoirs. The result shows that the error measures decrease approximately 3%. This improvement indicates that the inclusion of climate variables to model and simulate the inflows time series is a valid exercise and should be taken into consideration.

  20. An integrated approach for the validation of energy and environmental system analysis models : used in the validation of the Flexigas Excel BioGas model

    NARCIS (Netherlands)

    Pierie, Frank; van Someren, Christian; Liu, Wen; Bekkering, Jan; Hengeveld, Evert Jan; Holstein, J.; Benders, René M.J.; Laugs, Gideon A.H.; van Gemert, Wim; Moll, Henri C.

    2016-01-01

    A review has been completed for a verification and validation (V&V) of the (Excel) BioGas simulator or EBS model. The EBS model calculates the environmental impact of biogas production pathways using Material and Energy Flow Analysis, time dependent dynamics, geographic information, and Life Cycle

  1. An Excel Spreadsheet Model for States and Districts to Assess the Cost-Benefit of School Nursing Services.

    Science.gov (United States)

    Wang, Li Yan; O'Brien, Mary Jane; Maughan, Erin D

    2016-11-01

    This paper describes a user-friendly, Excel spreadsheet model and two data collection instruments constructed by the authors to help states and districts perform cost-benefit analyses of school nursing services delivered by full-time school nurses. Prior to applying the model, states or districts need to collect data using two forms: "Daily Nurse Data Collection Form" and the "Teacher Survey." The former is used to record daily nursing activities, including number of student health encounters, number of medications administered, number of student early dismissals, and number of medical procedures performed. The latter is used to obtain estimates for the time teachers spend addressing student health issues. Once inputs are entered in the model, outputs are automatically calculated, including program costs, total benefits, net benefits, and benefit-cost ratio. The spreadsheet model, data collection tools, and instructions are available at the NASN website ( http://www.nasn.org/The/CostBenefitAnalysis ).

  2. Flipping Excel

    Science.gov (United States)

    Frydenberg, Mark

    2013-01-01

    The "flipped classroom" model has become increasingly popular in recent years as faculty try new ways to engage students in the classroom. In a flipped classroom setting, students review the lecture online prior to the class session and spend time in class working on problems or exercises that would have been traditionally assigned as…

  3. Exploring the possible reasons why the UK Government commended the EFQM (European Foundation for Quality Management) excellence model as the framework for delivering governance in the new NHS.

    Science.gov (United States)

    Jackson, S

    1999-01-01

    A brief introduction into recent developments of the EFQM Excellence Model and the United Kingdom (UK) Government's agenda for ensuring that quality is at the heart of all decision making is given. In view of the Government explicitly commending the use of the EFQM Excellence Model to all organisations within the National Health Service, the author decides to explore the possible reasons behind the commendation. When comparing the EFQM Excellence Model with the Government's vision for quality, the former emerges as a more than ideal tool for any organisation wishing to commence or strengthen their journey on the road to quality and/or excellence; particularly as the EFQM Excellence Model is based on the principles of self-assessment, continuous improvement, learning and innovation, teamwork and a culture totally focused on the customer. Finally, ten possible reasons behind the Government commending the use of the Model are given.

  4. Using the business excellence model to effectively manage change within clinical support services.

    Science.gov (United States)

    Freer, J; Jackson, S

    1998-01-01

    This article describes the journey of managing the change from seven separate health providing units to one overall team providing a range of services. To facilitate the change the Malcolm Baldrige National Quality Award self-assessment model was used. The benefits and limitations of the model are described as are the activities undertaken to achieve a goal of delivering quality care within a customer driven rather than service driven focus. Finally the learning gained from the change is shared in an attempt to help others undertaking a similar journey.

  5. Improving Conceptual Understanding and Representation Skills through Excel-Based Modeling

    Science.gov (United States)

    Malone, Kathy L.; Schunn, Christian D.; Schuchardt, Anita M.

    2018-01-01

    The National Research Council framework for science education and the Next Generation Science Standards have developed a need for additional research and development of curricula that is both technologically model-based and includes engineering practices. This is especially the case for biology education. This paper describes a quasi-experimental…

  6. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick

    2013-01-01

    Structured Abstract Purpose: Sustainable Enterprise Excellence (SEE) is defined and developed through integration and expansion of business excellence modeling and sustainability thought. The intent is to enable simple yet reliable enterprise assessment of triple bottom line (TBL) performance...... and produce actionable enterprise foresight that can enable next best practices and sources of sustainable competitive advantage through innovation. Methodology: Key elements of SEE are identified from various business excellence and sustainability reporting sources, including the Global Reporting Initiative...... assessment approach similar in structure to those behind established excellence awards are developed that enable enterprise assessment of progress toward SEE. The resulting assessment is delivered in a highly consumable, combined narrative and graphic format referred to as a SEE NEWS Report. Practical...

  7. Design and competitive edge: A model for design management excellence in European SME's

    OpenAIRE

    Borja de Mozota, B

    2002-01-01

    This article suggests to use the conceptual model of Michael Porter Value Chain in order to integrate all the variables that explain the mechanism of value creation through design. The results of the study of 33 European SMES participating in the European Design Prize explain the role of design in the management of innovation, identify the variables that characterize design management and classify them according to the value chain concept. The main result of this research was the ...

  8. ANALYSIS OF THE BANDUNG CHANGES EXCELLENT POTENTIAL THROUGH INPUT-OUTPUT MODEL USING INDEX LE MASNE

    Directory of Open Access Journals (Sweden)

    Teti Sofia Yanti

    2017-03-01

    Full Text Available Input-Output Table is arranged to present an overview of the interrelationships and interdependence between units of activity (sector production in the whole economy. Therefore the input-output models are complete and comprehensive analytical tool. The usefulness of input-output tables is an analysis of the economic structure of the national/regional level which covers the structure of production and value-added (GDP of each sector. For the purposes of planning and evaluation of the outcomes of development that is comprehensive both national and smaller scale (district/city, a model for regional development planning approach can use the model input-output analysis. Analysis of Bandung Economic Structure did use Le Masne index, by comparing the coefficients of the technology in 2003 and 2008, of which nearly 50% change. The trade sector has grown very conspicuous than other areas, followed by the services of road transport and air transport services, the development priorities and investment Bandung should be directed to these areas, this is due to these areas can be thrust and be power attraction for the growth of other areas. The areas that experienced the highest decrease was Industrial Chemicals and Goods from Chemistry, followed by Oil and Refinery Industry Textile Industry Except For Garment.

  9. Regression analysis understanding and building business and economic models using Excel

    CERN Document Server

    Wilson, J Holton

    2012-01-01

    The technique of regression analysis is used so often in business and economics today that an understanding of its use is necessary for almost everyone engaged in the field. This book will teach you the essential elements of building and understanding regression models in a business/economic context in an intuitive manner. The authors take a non-theoretical treatment that is accessible even if you have a limited statistical background. It is specifically designed to teach the correct use of regression, while advising you of its limitations and teaching about common pitfalls. This book describe

  10. Contribution to the optical model study by the measurement of the reaction sections; Contribution au modele optique par la mesure de sections de reaction

    Energy Technology Data Exchange (ETDEWEB)

    Delaunay, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    Excitation functions of reaction cross-section {delta}{sub R} for protons were obtained between 5 and 11 MeV, for {sup 141}Pr and {sup 150}Nd by radioactive techniques and, between 9 and 12 MeV, for Cu and Ni by the transmission method. Results were compared to the prevision of the optical model. Calculations were made to see in what part {delta}{sub R} is able to reduce the ambiguities of the optical model. (author) [French] Des fonctions d'excitation de section efficace de reaction par protons {delta}{sub R} ont ete obtenues pour {sup 141}Pr et {sup 150}Nd, entre 5 et 11 MeV, par des methodes de radioactivite et pour Cu et Ni, entre 9 et 12 MeV, par la methode de transmission. Les resultats ont ete compares aux previsions du modele optique. Des calculs ont ete faits pour voir le role que peut jouer {delta}{sub R} pour diminuer les differentes ambiguites du modele optique. (auteur)

  11. Advanced methods for modeling water-levels and estimating drawdowns with SeriesSEE, an Excel add-in

    Science.gov (United States)

    Halford, Keith; Garcia, C. Amanda; Fenelon, Joe; Mirus, Benjamin B.

    2012-12-21

    Water-level modeling is used for multiple-well aquifer tests to reliably differentiate pumping responses from natural water-level changes in wells, or “environmental fluctuations.” Synthetic water levels are created during water-level modeling and represent the summation of multiple component fluctuations, including those caused by environmental forcing and pumping. Pumping signals are modeled by transforming step-wise pumping records into water-level changes by using superimposed Theis functions. Water-levels can be modeled robustly with this Theis-transform approach because environmental fluctuations and pumping signals are simulated simultaneously. Water-level modeling with Theis transforms has been implemented in the program SeriesSEE, which is a Microsoft® Excel add-in. Moving average, Theis, pneumatic-lag, and gamma functions transform time series of measured values into water-level model components in SeriesSEE. Earth tides and step transforms are additional computed water-level model components. Water-level models are calibrated by minimizing a sum-of-squares objective function where singular value decomposition and Tikhonov regularization stabilize results. Drawdown estimates from a water-level model are the summation of all Theis transforms minus residual differences between synthetic and measured water levels. The accuracy of drawdown estimates is limited primarily by noise in the data sets, not the Theis-transform approach. Drawdowns much smaller than environmental fluctuations have been detected across major fault structures, at distances of more than 1 mile from the pumping well, and with limited pre-pumping and recovery data at sites across the United States. In addition to water-level modeling, utilities exist in SeriesSEE for viewing, cleaning, manipulating, and analyzing time-series data.

  12. Neutrophilia, gelatinase release and microvascular leakage induced by human mast cell tryptase in a mouse model: Lack of a role of protease-activated receptor 2 (PAR2).

    Science.gov (United States)

    Khedr, M E M S; Abdelmotelb, A M; Pender, S L F; Zhou, X; Walls, A F

    2018-05-01

    Tryptase, the most abundant protease of the human mast cell, has been implicated as a key mediator of allergic inflammation that acts through activation of PAR2. To investigate the contribution of PAR2 in the pro-inflammatory actions mediated by tryptase in a mice model. We have injected recombinant human βII-tryptase into the peritoneum of PAR2-deficient and wild-type C57BL/6 mice. After 6, 12 and 24 hours, mice were killed, peritoneal lavage performed and inflammatory changes investigated. Tryptase stimulated an increase in neutrophil numbers in the peritoneum, but responses did not differ between PAR2-deficient and wild-type mice. Heat inactivation of tryptase or pre-incubation with a selective tryptase inhibitor reduced neutrophilia, but neutrophil accumulation was not elicited with a peptide agonist of PAR2 (SLIGRL-NH 2 ). Zymography indicated that tryptase stimulated the release of matrix metalloproteinases (MMP) 2 and 9 in the peritoneum of both mouse strains. Studies involving immunomagnetic isolation of neutrophils suggested that neutrophils represent the major cellular source of tryptase-induced MMP2 and MMP9. At 24 hours after tryptase injection, there was increased microvascular leakage as indicated by high levels of albumin in peritoneal lavage fluid, and this appeared to be partially abolished by heat-inactivating tryptase or addition of a protease inhibitor. There was no corresponding increase in levels of histamine or total protein. The extent of tryptase-induced microvascular leakage or gelatinase release into the peritoneum did not differ between PAR2-deficient and wild-type mice. Our findings indicate that tryptase is a potent stimulus for neutrophil accumulation, MMP release and microvascular leakage. Although these actions required an intact catalytic site, the primary mechanism of tryptase in vivo would appear to involve processes independent of PAR2. © 2018 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd.

  13. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system.

    Science.gov (United States)

    Hu, Longhua; Vecchiarelli, Anthony G; Mizuuchi, Kiyoshi; Neuman, Keir C; Liu, Jian

    2015-12-22

    The segregation of DNA before cell division is essential for faithful genetic inheritance. In many bacteria, segregation of low-copy number plasmids involves an active partition system composed of a nonspecific DNA-binding ATPase, ParA, and its stimulator protein ParB. The ParA/ParB system drives directed and persistent movement of DNA cargo both in vivo and in vitro. Filament-based models akin to actin/microtubule-driven motility were proposed for plasmid segregation mediated by ParA. Recent experiments challenge this view and suggest that ParA/ParB system motility is driven by a diffusion ratchet mechanism in which ParB-coated plasmid both creates and follows a ParA gradient on the nucleoid surface. However, the detailed mechanism of ParA/ParB-mediated directed and persistent movement remains unknown. Here, we develop a theoretical model describing ParA/ParB-mediated motility. We show that the ParA/ParB system can work as a Brownian ratchet, which effectively couples the ATPase-dependent cycling of ParA-nucleoid affinity to the motion of the ParB-bound cargo. Paradoxically, this resulting processive motion relies on quenching diffusive plasmid motion through a large number of transient ParA/ParB-mediated tethers to the nucleoid surface. Our work thus sheds light on an emergent phenomenon in which nonmotor proteins work collectively via mechanochemical coupling to propel cargos-an ingenious solution shaped by evolution to cope with the lack of processive motor proteins in bacteria.

  14. Penerapan european foundation for quality management’s (efqm excellence model pada sistem pengukuran kinerja jurusan Teknik Mesin Universitas Udayana

    Directory of Open Access Journals (Sweden)

    I Made Dwi Budiana Penindra

    2018-01-01

    , dari 40 stakeholder requirement dijabarkan menjadi 15 KPI. Implementasi pada semester genap 2014/2015 menunjukkan peningkatan sebesar 83,92 % dari periode sebelumnya dengan Indeks Performance Indicator sebesar 773,35. Kata kunci: Pengukuran kinerja, European Foundation for Quality Management’s (EFQM Execellence Model, Metode Objectives Matrix (OMAX, Integrated Performance Measurement Systems (IPMS, dan Analytical Hierarcy Process (AHP Abstract Globalization is a phenomenon that can not be avoided in the governance of our lives where competition between countries become more open, especially in the field of human resources. To deal with the situation, the college is expected to be the center of the implementation and development of higher education that generate benefits and improve the quality of life of society, nation and state. Department of Mechanical Engineering is one of the departments that have earned accreditation from BAN PT where currently only 20% of accredited departments in the university. In order to improve its performance, it would need to design an integrated performance measurement system which is now the Department of Mechanical Engineering has not had a good performance measurement system yet. Enhancing performance measurement systems that already exist, analysis, design and implementation of performance measurement system will be done with the European Foundation for Quality Management's (EFQM excellence model wherein the method is integrated by several methods, namely Methods Objectives Matrix (OMAX, Integrated Performance Measurement Systems (IPMS, and Hierarcy Analytical Process (AHP in the Department of Mechanical Engineering University of Udayana. Steps or details of the research methods to be expected is as following steps: Selection Method of Measuring Productivity, Types and Data Collection Methods, Identification Indicators or the Criterion productivity will be measured, Giving Weights From Each KPI The Measured, Data Processing or

  15. The EFQM excellence model: European and Dutch experiences with the EFQM approach in health care. European Foundation for Quality Management.

    Science.gov (United States)

    Nabitz, U; Klazinga, N; Walburg, J

    2000-06-01

    One way to meet the challenges in creating a high performance organization in health care is the approach of the European Foundation for Quality Management (EFQM). The Foundation is in the tradition of the American Malcolm Baldrige Award and was initiated by the European Commission and 14 European multi-national organizations in 1988. The essence of the approach is the EFQM Model, which can be used as a self-assessment instrument on all levels of a health care organization and as an auditing instrument for the Quality Award. In 1999 the EFQM Model was revised but its principles remained the same. In The Netherlands many health care organizations apply the EFQM Model. In addition to improvement projects, peer review of professional practices, accreditation and certification, the EFQM Approach is used mainly as a framework for quality management and as a conceptualization for organizational excellence. The Dutch National Institute for Quality, the Instituut Nederlandse Kwaliteit, delivers training and supports self-assessment and runs the Dutch quality award programme. Two specific guidelines for health care organizations, 'Positioning and Improving' and 'Self-Assessment', have been developed and are used frequently. To illustrate the EFQM approach in The Netherlands, the improvement project of the Jellinek Centre is described. The Jellinek Centre conducted internal and external assessments and received in 1996, as the first health care organization, the Dutch Quality Prize.

  16. VOLATILECALC: A silicate melt-H2O-CO2 solution model written in Visual Basic for excel

    Science.gov (United States)

    Newman, S.; Lowenstern, J. B.

    2002-01-01

    We present solution models for the rhyolite-H2O-CO2 and basalt-H2O-CO2 systems at magmatic temperatures and pressures below ~ 5000 bar. The models are coded as macros written in Visual Basic for Applications, for use within MicrosoftR Excel (Office'98 and 2000). The series of macros, entitled VOLATILECALC, can calculate the following: (1) Saturation pressures for silicate melt of known dissolved H2O and CO2 concentrations and the corresponding equilibrium vapor composition; (2) open- and closed-system degassing paths (melt and vapor composition) for depressurizing rhyolitic and basaltic melts; (3) isobaric solubility curves for rhyolitic and basaltic melts; (4) isoplethic solubility curves (constant vapor composition) for rhyolitic and basaltic melts; (5) polybaric solubility curves for the two end members and (6) end member fugacities of H2O and CO2 vapors at magmatic temperatures. The basalt-H2O-CO2 macros in VOLATILECALC are capable of calculating melt-vapor solubility over a range of silicate-melt compositions by using the relationships provided by Dixon (American Mineralogist 82 (1997) 368). The output agrees well with the published solution models and experimental data for silicate melt-vapor systems for pressures below 5000 bar. ?? 2002 Elsevier Science Ltd. All rights reserved.

  17. LES APPROCHES PLURIELLES DANS LE MODELE CARAP: SAVOIRS ACQUIS PAR L'INTERCOMPREHENSION

    Directory of Open Access Journals (Sweden)

    Constantin Felicia

    2012-07-01

    means of the encyclopaedic knowledge of the world, activity practiced by inferential type strategies. The regular observation of ICE type training sessions has led us to a reflection applied to non-philological learning environment. We consider that organizing a module of initiation in French for beginner economic students, a course relying on intercomprehension principles, would be an excellent introduction to multilingualism. In this paper we will tackle the knowledge that, according to CARAP, seems attainable by means of this alternative method of teaching - learning a language, in the light, even if only virtual at the moment, of the introduction of French in the curriculum by specific means of intercomprehension. Established as prolegomena to the traditional study, an introductory course of intercomprehension of French would be able to provide students with quicker global linguistic knowledge otherwise acquired in a longer period of time, with more effort and without guaranteed results.

  18. Writing Excel Macros with VBA

    CERN Document Server

    Roman, Steven

    2008-01-01

    To achieve the maximum control and flexibility from Microsoft® Excel often requires careful custom programming using the VBA (Visual Basic for Applications) language. Writing Excel Macros with VBA, 2nd Edition offers a solid introduction to writing VBA macros and programs, and will show you how to get more power at the programming level: focusing on programming languages, the Visual Basic Editor, handling code, and the Excel object model.

  19. Gravitation: Field theory par excellence Newton, Einstein, and beyond

    International Nuclear Information System (INIS)

    Yilmaz, H.

    1984-01-01

    Newtonian gravity satifies the two principles of equivalence m/sub i/ = m/sub p/ (the passive principle) and m/sub a/ = m/sub p/ (the active principle). A relativistic gauge field concept in D = s+1 dimensional curved-space will, in general, violate these two principles as in m/sub p/ = αm/sub i/, m/sub a/ = lambdam/sub p/ where α = D: 3 and lambda measures the presence of the field stress-energy t/sup ν//sub μ/ in the field equations. It is shown that α = 1, lambda = 0 corresponds to general relativity and α = 1, lambda = 1 to the theory of the author. It is noted that the correspondence limit of general relativity is not Newton's theory but a theory suggested by Robert Hooke a few years before Newton published his in Principia. The gauge is independent of the two principles but had to do with local special relativistic correspondence and compatibility with quantum mechanics. It is shown that unless α = 1, lambda = 1 the generalized theory cannot predict correctly many observables effects, including the 532'' per century Newtonian part in Mercury's perihelion advance

  20. Tiit Pääsuke - maalija par excellence / Ants Juske

    Index Scriptorium Estoniae

    Juske, Ants, 1956-2016

    2006-01-01

    Tiit Pääsukese loomingust, kes peab ennast inimeste maalijaks, kuid nad on talle värviga modelleerimisel vaid vahendiks põneva pildimaailma loomisel. Illustratsiooniks "Punase kleidiga naine". Õli, lõuend, 1974. Eesti Kunstimuuseum

  1. Aldred scott warthin: Pathologist and teacher par excellence

    Directory of Open Access Journals (Sweden)

    Vineeth G Nair

    2017-01-01

    Full Text Available Born in 1866, Aldred Scott Warthin was a pathologist and teacher of great repute. Even though many know him from his eponyms, the true value of his achievements, and how far he was ahead of his peers, is known to but a few modern day medical students. It was in fact, based on his work, that Henry Lynch came up with his theories on the genetic nature of cancer. He died in 1931 leaving a lot of work unfinished.

  2. Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

    Science.gov (United States)

    Jones, R. I. G.

    2005-12-01

    Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

  3. Excel Initiative: Excellence in Youth Programming

    Directory of Open Access Journals (Sweden)

    Lynne M. Borden

    2015-06-01

    Full Text Available The Excellence in Youth Programming (Excel Initiative strives to support youth programs in delivering high quality programs. The backbone of Excel is the Youth Development Observational Tool (YDOT which allows for the virtual assessment of program staff who work with children and youth ages 9-18 years. The YDOT also allows Excel to provide structured feedback to programs. Excel has several unique features, including a virtual platform and a focus on the relationships between adults and youth participating in after-school programs. Offering structured assessment and interaction online eliminates expenses, provides convenient access for programs around the globe, and allows for unobtrusive assessment of worker-youth interactions. Excel is also integrated into a broader network of resources, tools, and research for those working with children and youth ages 9-18.

  4. Modeling of pollutant emissions from road transport; Modelisation des emissions de polluants par le transport routier

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    COPERT III (computer programme to calculate emissions from road transport) is the third version of an MS Windows software programme aiming at the calculation of air pollutant emissions from road transport. COPERT estimates emissions of all regulated air pollutants (CO, NO{sub x}, VOC, PM) produced by different vehicle categories as well as CO{sub 2} emissions on the basis of fuel consumption. This research seminar was organized by the French agency of environment and energy mastery (Ademe) around the following topics: the uncertainties and sensitiveness analysis of the COPERT III model, the presentation of case studies that use COPERT III for the estimation of road transport emissions, and the future of the modeling of road transport emissions: from COPERT III to ARTEMIS (assessment and reliability of transport emission models and inventory systems). This document is a compilation of 8 contributions to this seminar and dealing with: the uncertainty and sensitiveness analysis of the COPERT III model; the road mode emissions of the ESCOMPTE program: sensitivity study; the sensitivity analysis of the spatialized traffic at the time-aggregation level: application in the framework of the INTERREG project (Alsace); the road transport aspect of the regional air quality plan of Bourgogne region: exhaustive consideration of the road network; intercomparison of tools and methods for the inventory of emissions of road transport origin; evolution of the French park of vehicles by 2025: new projections; application of COPERT III to the French context: a new version of IMPACT-ADEME; the European ARTEMIS project: new structural considerations for the modeling of road transport emissions. (J.S.)

  5. Parallelization Experience with Four Canonical Econometric Models Using ParMitISEM

    Directory of Open Access Journals (Sweden)

    Nalan Baştürk

    2016-03-01

    Full Text Available This paper presents the parallel computing implementation of the MitISEM algorithm, labeled Parallel MitISEM. The basic MitISEM algorithm provides an automatic and flexible method to approximate a non-elliptical target density using adaptive mixtures of Student-t densities, where only a kernel of the target density is required. The approximation can be used as a candidate density in Importance Sampling or Metropolis Hastings methods for Bayesian inference on model parameters and probabilities. We present and discuss four canonical econometric models using a Graphics Processing Unit and a multi-core Central Processing Unit version of the MitISEM algorithm. The results show that the parallelization of the MitISEM algorithm on Graphics Processing Units and multi-core Central Processing Units is straightforward and fast to program using MATLAB. Moreover the speed performance of the Graphics Processing Unit version is much higher than the Central Processing Unit one.

  6. ParPor: Particles in Pores. Stochastic Modeling of Polydisperse Transport

    DEFF Research Database (Denmark)

    Yuan, Hao

    2010-01-01

    Liquid flow containing particles in the different types of porous media appear in a large variety of practically important industrial and natural processes. The project aims at developing a stochastic model for the deep bed filtration process in which the polydisperse suspension flow...... in the polydisperse porous media. Instead of the traditional parabolic Advection-Dispersion Equation (ADE) the novel elliptic PDE based on the Continuous Time Random Walk is adopted for the particle size kinetics. The pore kinetics is either described by the stochastic size exclusion mechanism or the incomplete pore...

  7. Abnormal chloride homeostasis in the substancia nigra pars reticulata contributes to locomotor deficiency in a model of acute liver injury.

    Directory of Open Access Journals (Sweden)

    Yan-Ling Yang

    Full Text Available BACKGROUND: Altered chloride homeostasis has been thought to be a risk factor for several brain disorders, while less attention has been paid to its role in liver disease. We aimed to analyze the involvement and possible mechanisms of altered chloride homeostasis of GABAergic neurons within the substantia nigra pars reticulata (SNr in the motor deficit observed in a model of encephalopathy caused by acute liver failure, by using glutamic acid decarboxylase 67 - green fluorescent protein knock-in transgenic mice. METHODS: Alterations in intracellular chloride concentration in GABAergic neurons within the SNr and changes in the expression of two dominant chloride homeostasis-regulating genes, KCC2 and NKCC1, were evaluated in mice with hypolocomotion due to hepatic encephalopathy (HE. The effects of pharmacological blockade and/or activation of KCC2 and NKCC1 functions with their specific inhibitors and/or activators on the motor activity were assessed. RESULTS: In our mouse model of acute liver injury, chloride imaging indicated an increase in local intracellular chloride concentration in SNr GABAergic neurons. In addition, the mRNA and protein levels of KCC2 were reduced, particularly on neuronal cell membranes; in contrast, NKCC1 expression remained unaffected. Furthermore, blockage of KCC2 reduced motor activity in the normal mice and led to a further deteriorated hypolocomotion in HE mice. Blockade of NKCC1 was not able to normalize motor activity in mice with liver failure. CONCLUSION: Our data suggest that altered chloride homeostasis is likely involved in the pathophysiology of hypolocomotion following HE. Drugs aimed at restoring normal chloride homeostasis would be a potential treatment for hepatic failure.

  8. TK Modeler version 1.0, a Microsoft® Excel®-based modeling software for the prediction of diurnal blood/plasma concentration for toxicokinetic use.

    Science.gov (United States)

    McCoy, Alene T; Bartels, Michael J; Rick, David L; Saghir, Shakil A

    2012-07-01

    TK Modeler 1.0 is a Microsoft® Excel®-based pharmacokinetic (PK) modeling program created to aid in the design of toxicokinetic (TK) studies. TK Modeler 1.0 predicts the diurnal blood/plasma concentrations of a test material after single, multiple bolus or dietary dosing using known PK information. Fluctuations in blood/plasma concentrations based on test material kinetics are calculated using one- or two-compartment PK model equations and the principle of superposition. This information can be utilized for the determination of appropriate dosing regimens based on reaching a specific desired C(max), maintaining steady-state blood/plasma concentrations, or other exposure target. This program can also aid in the selection of sampling times for accurate calculation of AUC(24h) (diurnal area under the blood concentration time curve) using sparse-sampling methodologies (one, two or three samples). This paper describes the construction, use and validation of TK Modeler. TK Modeler accurately predicted blood/plasma concentrations of test materials and provided optimal sampling times for the calculation of AUC(24h) with improved accuracy using sparse-sampling methods. TK Modeler is therefore a validated, unique and simple modeling program that can aid in the design of toxicokinetic studies. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. The Exploration and Practice of Gradually Industrialization Model in Software Engineering Education: A Factual Instance of the Excellent Engineer Plan of China

    Science.gov (United States)

    Liu, Shu; Ma, Peijun; Li, Dong

    2012-01-01

    The current education model and practices in the Higher education sector in China have been successful in educating students for academic excellence, for producing industry-linked and practice-oriented graduates, who could quickly fit into the industrial working environment, has been a problem. There is a big gap between the theoretical knowledge…

  10. Closing the Excellence Gap: Investigation of an Expanded Talent Search Model for Student Selection into an Extracurricular STEM Program in Rural Middle Schools

    Science.gov (United States)

    Assouline, Susan G.; Ihrig, Lori M.; Mahatmya, Duhita

    2017-01-01

    High-potential students from underresourced rural schools face barriers that reduce options for academic advancement, which widens the excellence gap between them and their more affluent, but similar ability peers. The goal of this study was to investigate the effectiveness of an expanded above-level testing model to identify high-potential rural…

  11. Using user models in Matlab® within the Aspen Plus® interface with an Excel® link

    Directory of Open Access Journals (Sweden)

    Javier Fontalvo Alzate

    2014-05-01

    Full Text Available Process intensification and new technologies require tools for process design that can be integrated into well-known simulation software, such as Aspen Plus®. Thus, unit operations that are not included in traditional Aspen Plus software packages can be simulated with Matlab® and integrated within the Aspen Plus interface. In this way, the user can take advantage of all of the tools of Aspen Plus, such as optimization, sensitivity analysis and cost estimation. This paper gives a detailed description of how to implement this integration. The interface between Matlab and Aspen Plus is accomplished by sending the relevant information from Aspen Plus to Excel, which feeds the information to a Matlab routine. Once the Matlab routine processes the information, it is returned to Excel and to Aspen Plus. This paper includes the Excel and Matlab template files so the reader can implement their own simulations. By applying the protocol described here, a hybrid distillation-vapor permeation system has been simulated as an example of the applications that can be implemented. For the hybrid system, the effect of membrane selectivity on membrane area and reboiler duty for the partial dehydration of ethanol is studied. Very high selectivities are not necessarily required for an optimum hybrid distillation and vapor permeation system.

  12. Use of Excel ion exchange equilibrium solver with WinGEMS to model and predict NPE distribution in the Mead/Westvaco Evandale, TX, hardwood bleach plant

    Science.gov (United States)

    Christopher Litvay; Alan Rudie; Peter Hart

    2003-01-01

    An Excel spreadsheet developed to solve the ion-exchange equilibrium in wood pulps has been linked by dynamic data exchange to WinGEMS and used to model the non-process elements in the hardwood bleach plant of the Mead/Westvaco Evandale mill. Pulp and filtrate samples were collected from the diffusion washers and final wash press of the bleach plant. A WinGEMS model of...

  13. Excel 2013 simplified

    CERN Document Server

    McFedries, Paul

    2013-01-01

    A friendly, visual approach to learning the basics of Excel 2013 As the world's leading spreadsheet program, Excel is a spreadsheet and data analysis tool that is part of the Microsoft Office suite. The new Excel 2013 includes new features and functionalities that require users of older versions to re-learn the application. However, whether you're switching from an earlier version or learning Excel for the first time, this easy-to-follow visual guide gets you going with Excel 2013 quickly and easily. Numbered steps as well as full-color screen shots, concise information, and helpfu

  14. Excel 2010 Made Simple

    CERN Document Server

    Katz, Abbott

    2011-01-01

    Get the most out of Excel 2010 with Excel 2010 Made Simple - learn the key features, understand what's new, and utilize dozens of time-saving tips and tricks to get your job done. Over 500 screen visuals and clear-cut instructions guide you through the features of Excel 2010, from formulas and charts to navigating around a worksheet and understanding Visual Basic for Applications (VBA) and macros. Excel 2010 Made Simple takes a practical and highly effective approach to using Excel 2010, showing you the best way to complete your most common spreadsheet tasks. You'll learn how to input, format,

  15. Excel 2013 formulas

    CERN Document Server

    Walkenbach, John

    2013-01-01

    Maximize the power of Excel 2013 formulas with this must-have Excel reference John Walkenbach, known as ""Mr. Spreadsheet,"" is a master at deciphering complex technical topics and Excel formulas are no exception. This fully updated book delivers more than 800 pages of Excel 2013 tips, tricks, and techniques for creating formulas that calculate, developing custom worksheet functions with VBA, debugging formulas, and much more. Demonstrates how to use all the latest features in Excel 2013 Shows how to create financial formulas and tap into the power of array formulas

  16. Master VISUALLY Excel 2010

    CERN Document Server

    Marmel, Elaine

    2010-01-01

    The complete visual reference on Excel basics. Aimed at visual learners who are seeking an all-in-one reference that provides in-depth coveage of Excel from a visual viewpoint, this resource delves into all the newest features of Excel 2010. You'll explore Excel with helpful step-by-step instructions that show you, rather than tell you, how to navigate Excel, work with PivotTables and PivotCharts, use macros to streamline work, and collaborate with other users in one document.: This two-color guide features screen shots with specific, numbered instructions so you can learn the actions you need

  17. Quality Management and Business Excellence

    OpenAIRE

    Vasile Dinu

    2017-01-01

    An excellent organization involves much more than the implementation and the certification of one or more models of management systems. It means developing techniques and tools of busin excellence which lead the organization to outstanding performance on quality, costs and deadlines in order to meet the expectations of all their stakeholders. Such an approach is needed especially in the context of an economy marked by globalization, extremely complex and dynamic that causes spectacular change...

  18. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...

  19. Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: the Modelling Algorithm Pathways in Guidelines (MAPGuide) project.

    Science.gov (United States)

    Lord, J; Willis, S; Eatock, J; Tappenden, P; Trapero-Bertran, M; Miners, A; Crossan, C; Westby, M; Anagnostou, A; Taylor, S; Mavranezouli, I; Wonderling, D; Alderson, P; Ruiz, F

    2013-12-01

    National Institute for Health and Care Excellence (NICE) clinical guidelines (CGs) make recommendations across large, complex care pathways for broad groups of patients. They rely on cost-effectiveness evidence from the literature and from new analyses for selected high-priority topics. An alternative approach would be to build a model of the full care pathway and to use this as a platform to evaluate the cost-effectiveness of multiple topics across the guideline recommendations. In this project we aimed to test the feasibility of building full guideline models for NICE guidelines and to assess if, and how, such models can be used as a basis for cost-effectiveness analysis (CEA). A 'best evidence' approach was used to inform the model parameters. Data were drawn from the guideline documentation, advice from clinical experts and rapid literature reviews on selected topics. Where possible we relied on good-quality, recent UK systematic reviews and meta-analyses. Two published NICE guidelines were used as case studies: prostate cancer and atrial fibrillation (AF). Discrete event simulation (DES) was used to model the recommended care pathways and to estimate consequent costs and outcomes. For each guideline, researchers not involved in model development collated a shortlist of topics suggested for updating. The modelling teams then attempted to evaluate options related to these topics. Cost-effectiveness results were compared with opinions about the importance of the topics elicited in a survey of stakeholders. The modelling teams developed simulations of the guideline pathways and disease processes. Development took longer and required more analytical time than anticipated. Estimates of cost-effectiveness were produced for six of the nine prostate cancer topics considered, and for five of eight AF topics. The other topics were not evaluated owing to lack of data or time constraints. The modelled results suggested 'economic priorities' for an update that differed from

  20. Excel 2010 bible

    CERN Document Server

    Walkenbach, John

    2010-01-01

    A comprehensive reference to the newest version of the world's most popular spreadsheet application: Excel 2010 John Walkenbach's name is synonymous with excellence in computer books that decipher complex technical topics. Known as ""Mr. Spreadsheet,"" Walkenbach shows you how to maximize the power of all the new features of Excel 2010. An authoritative reference, this perennial bestseller proves itself indispensable no matter your level of skill, from Excel beginners and intermediate users to power users and potential power users everywhere. Fully updated for the new release, this

  1. Development of a Microsoft Excel tool for one-parameter Rasch model of continuous items: an application to a safety attitude survey.

    Science.gov (United States)

    Chien, Tsair-Wei; Shao, Yang; Kuo, Shu-Chun

    2017-01-10

    Many continuous item responses (CIRs) are encountered in healthcare settings, but no one uses item response theory's (IRT) probabilistic modeling to present graphical presentations for interpreting CIR results. A computer module that is programmed to deal with CIRs is required. To present a computer module, validate it, and verify its usefulness in dealing with CIR data, and then to apply the model to real healthcare data in order to show how the CIR that can be applied to healthcare settings with an example regarding a safety attitude survey. Using Microsoft Excel VBA (Visual Basic for Applications), we designed a computer module that minimizes the residuals and calculates model's expected scores according to person responses across items. Rasch models based on a Wright map and on KIDMAP were demonstrated to interpret results of the safety attitude survey. The author-made CIR module yielded OUTFIT mean square (MNSQ) and person measures equivalent to those yielded by professional Rasch Winsteps software. The probabilistic modeling of the CIR module provides messages that are much more valuable to users and show the CIR advantage over classic test theory. Because of advances in computer technology, healthcare users who are familiar to MS Excel can easily apply the study CIR module to deal with continuous variables to benefit comparisons of data with a logistic distribution and model fit statistics.

  2. "Excellence" in STEM Education

    Science.gov (United States)

    Clark, Aaron C.

    2012-01-01

    So what does it take to achieve excellence in STEM education? That is the title of the author's presentation delivered at International Technology and Engineering Educators Association's (ITEEA's) FTEE "Spirit of Excellence" Breakfast on March 16, 2012, in Long Beach, California. In preparation for this presentation, the author went back and read…

  3. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events ...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....

  4. Development of a Microsoft Excel tool for one-parameter Rasch model of continuous items: an application to a safety attitude survey

    Directory of Open Access Journals (Sweden)

    Tsair-Wei Chien

    2017-01-01

    Full Text Available Abstract Background Many continuous item responses (CIRs are encountered in healthcare settings, but no one uses item response theory’s (IRT probabilistic modeling to present graphical presentations for interpreting CIR results. A computer module that is programmed to deal with CIRs is required. To present a computer module, validate it, and verify its usefulness in dealing with CIR data, and then to apply the model to real healthcare data in order to show how the CIR that can be applied to healthcare settings with an example regarding a safety attitude survey. Methods Using Microsoft Excel VBA (Visual Basic for Applications, we designed a computer module that minimizes the residuals and calculates model’s expected scores according to person responses across items. Rasch models based on a Wright map and on KIDMAP were demonstrated to interpret results of the safety attitude survey. Results The author-made CIR module yielded OUTFIT mean square (MNSQ and person measures equivalent to those yielded by professional Rasch Winsteps software. The probabilistic modeling of the CIR module provides messages that are much more valuable to users and show the CIR advantage over classic test theory. Conclusions Because of advances in computer technology, healthcare users who are familiar to MS Excel can easily apply the study CIR module to deal with continuous variables to benefit comparisons of data with a logistic distribution and model fit statistics.

  5. Modelling of ratchetting with the Chaboche elastoplastic model modified by Burlet and Cailletaud; Modelisation des phenomenes de deformation progressive par le modele elastoplastique de Chaboche modifie par Burlet et Cailletaud

    Energy Technology Data Exchange (ETDEWEB)

    Geyer, P

    1994-01-01

    A fine modelling of the material`s behaviour can be necessary to study the mechanical strength of nuclear power plant`s components under cyclic loads. The modelling of cyclic plasticity made great progress during the past 20 years. Ratchetting is one of the last phenomena for which numerical models have to be improved. We give in this document a state of the art report on research in this field. We notably show the basically different character of ratchetting in uniaxial and biaxial loading tests, usually distinguished as 1D and 2D ratchetting. On the basis of this overview, we selected the kinematic hardening formulation proposed by Burlet and Cailletaud, which we coupled with the Chaboche elastoplastic model with two non linear kinematic hardening variables to improve the modelling of 2D ratchetting. We use the experimental results on the austenitic steel 316L at 20 and 300 deg C under uniaxial loadings (low cycle fatigue) and biaxial loadings (traction-torsion) to study the new model capabilities. We get a good modelling of ratchetting in biaxial loadings. The model has been installed in the ASTER code under the name of UBRLET. It now has to be qualified by component analysis calculations. (author). 25 refs., 30 figs., 11 tabs., 3 annexes.

  6. Mechanical disequilibria in two-phase flow models: approaches by relaxation and by a reduced model; Modelisation des desequilibres mecaniques dans les ecoulements diphasiques: approches par relaxation et par modele reduit

    Energy Technology Data Exchange (ETDEWEB)

    Labois, M

    2008-10-15

    This thesis deals with hyperbolic models for the simulation of compressible two-phase flows, to find alternatives to the classical bi-fluid model. We first establish a hierarchy of two-phase flow models, obtained according to equilibrium hypothesis between the physical variables of each phase. The use of Chapman-Enskog expansions enables us to link the different existing models to each other. Moreover, models that take into account small physical unbalances are obtained by means of expansion to the order one. The second part of this thesis focuses on the simulation of flows featuring velocity unbalances and pressure balances, in two different ways. First, a two-velocity two-pressure model is used, where non-instantaneous velocity and pressure relaxations are applied so that a balancing of these variables is obtained. A new one-velocity one-pressure dissipative model is then proposed, where the arising of second-order terms enables us to take into account unbalances between the phase velocities. We develop a numerical method based on a fractional step approach for this model. (author)

  7. CFD analysis of PAR performance as function of inlet design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical and Energy systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University (Korea, Republic of)

    2016-01-15

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  8. CFD analysis of PAR performance as function of inlet design

    International Nuclear Information System (INIS)

    Park, Kweonha; Khor, Chong Lee

    2016-01-01

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  9. Beginning Microsoft Excel 2010

    CERN Document Server

    Katz, Abbott

    2010-01-01

    Beginning Microsoft Excel 2010 is a practical, step-by-step guide to getting started with the world's most widely used spreadsheet application. The book offers a hands-on approach to learning how to create and edit spreadsheets, use various calculation formulas, employ charts/graphs, and get work done efficiently. Microsoft is rolling out several new features with Excel 2010 - perhaps the most notable is the ability to use Excel 2010 online and this collaborate on a project in real time. Beginning Microsoft Office 2010 keeps you up-to-date with all of these new features and more. What you'll l

  10. Excel 2003 for dummies

    CERN Document Server

    Harvey, Greg

    2013-01-01

    Every time you turn around, you run into Excel. It's on yourPC at work. It's on your PC at home. You get Excel files fromyour boss. Wouldn't you like to understand this powerfulMicrosoft Office spreadsheet program, once and for all? Now, youcan crunch financial data, add sparkle to presentations, convertstatic lists of numbers into impressive charts, and discover whatall the shouting's about regarding databases, formulas, andcells. You may even decide that getting organized with a goodspreadsheet is downright useful and fun! Flip open Excel 2003 For Dummies, and you'llquickly start getting th

  11. Striving for excellence

    International Nuclear Information System (INIS)

    Vaughn, G.E.

    1986-01-01

    With guidance and assistance from the Institute of Nuclear Power Operations (INPO), nuclear utilities are striving for excellence by making steady improvements in industry performance indicators. Duke Power Company has solidly committed to support the industry's effort to obtain higher standards of excellence. Dedicated, highly trained employees, who are motivated to making it happen, carry out this commitment within a management framework which includes: 1) top management support and direct involvement; 2) a strategy to achieve excellence over the long run; 3) a nuclear management priority structure; and 4) a goals program

  12. Excel dashboards and reports

    CERN Document Server

    Alexander, Michael

    2013-01-01

    Learn to use Excel dashboards and reports to better conceptualize data Updated for all the?latest features and capabilities of Excel 2013, this go-to resource provides you with in-depth coverage of the individual functions and tools that can be used to create?compelling Excel reports. Veteran author Michael Alexander walks you through the most effective ways to present and report data. Featuring a comprehensive review of a wide array of technical and analytical concepts, this essential guide helps you go from reporting data with simple tables full of dull numbers to presenting

  13. Excel2003 Formulas

    CERN Document Server

    Walkenbach, John

    2011-01-01

    Everything you need to know about* Mastering operators, error values, naming techniques, and absolute versus relative references* Debugging formulas and using the auditing tools* Importing and exporting XML files and mapping the data to specific cells* Using Excel 2003's rights management feature* Working magic with array formulas* Developing custom formulas to produce the results you needHere's the formula for Excel excellenceFormulas are the lifeblood of spreadsheets, and no one can bring a spreadsheet to life like John Walkenbach. In this detailed reference guide, he delves deeply into unde

  14. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Williams, Joseph; Eskildsen, Jacob Kjær

    , supply chain, customer-related, human capital, financial, marketplace, societal, and environmental performance. Sustainable Enterprise Excellence integrates ethical, efficient and effective (E3) enterprise governance with 3E (equity, ecology, economy) Triple Top Line strategy throughout enterprise...

  15. Obsessed with excellence

    Indian Academy of Sciences (India)

    Lawrence

    dia and develop new areas of research in their perspective laborato- ries. A staunch ... Her unique quality for allowing individual scientific tal- ents to bloom, in ... of excellence in sci- ence, Dr Ranadive made an indelible impression on my mind.

  16. Striving for Excellence

    DEFF Research Database (Denmark)

    Hattke, Fabian; Blaschke, Steffen

    2015-01-01

    Purpose: - The purpose of this paper is to evaluate the influence of top management team diversity on academic excellence in universities. Academic excellence is conceptualized as successfully gaining funds for inter-organizational research collaborations, interdisciplinary graduate schools......, and high ranked scientific reputation. Design/methodology/approach: -The study applies upper echelon theory to universities. Three hypotheses are developed: 1) (Overall) top management team heterogeneity is positively associated with successful funding of excellence clusters, 2) (Overall) top management...... no significant effects. Besides top management team composition, we find that a high number of faculties and a broad inclusion of internal status groups (students, tenured faculty, academic and administrative staff) and external stakeholders in decision making processes may enhance academic excellence...

  17. Achieveing Organizational Excellence Through

    OpenAIRE

    Mehdi Abzari; Mohammadreza Dalvi

    2009-01-01

    AbstractToday, In order to create motivation and desirable behavior in employees, to obtain organizational goals,to increase human resources productivity and finally to achieve organizational excellence, top managers oforganizations apply new and effective strategies. One of these strategies to achieve organizational excellenceis creating desirable corporate culture. This research has been conducted to identify the path to reachorganizational excellence by creating corporate culture according...

  18. Leading Others Toward Excellence.

    Science.gov (United States)

    Hupp, James R

    2015-12-01

    This essay puts forth the proposition that academic program excellence does not arise by accident. Effective leadership is required. To support this proposition, the essay discusses the characteristics common to effective leaders. It then proceeds to use the example of a successful academic oral-maxillofacial surgery department and characteristics of its leader to provide evidence that excellence derives from effective leadership. Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  19. A Comparison of Video Modeling, Text-Based Instruction, and No Instruction for Creating Multiple Baseline Graphs in Microsoft Excel

    Science.gov (United States)

    Tyner, Bryan C.; Fienup, Daniel M.

    2015-01-01

    Graphing is socially significant for behavior analysts; however, graphing can be difficult to learn. Video modeling (VM) may be a useful instructional method but lacks evidence for effective teaching of computer skills. A between-groups design compared the effects of VM, text-based instruction, and no instruction on graphing performance.…

  20. Conditions for excellence in teaching in medical education: The Frankfurt Model to ensure quality in teaching and learning

    Directory of Open Access Journals (Sweden)

    Giesler, Marianne

    2017-10-01

    Full Text Available Background: There is general consensus that the organizational and administrative aspects of academic study programs exert an important influence on teaching and learning. Despite this, no comprehensive framework currently exists to describe the conditions that affect the quality of teaching and learning in medical education. The aim of this paper is to systematically and comprehensively identify these factors to offer academic administrators and decision makers interested in improving teaching a theory-based and, to an extent, empirically founded framework on the basis of which improvements in teaching quality can be identified and implemented.Method: Primarily, the issue was addressed by combining a theory-driven deductive approach with an experience based, “best evidence” one during the course of two workshops held by the GMA Committee on Personnel and Organizational Development in Academic Teaching (POiL in Munich (2013 and Frankfurt (2014. Two models describing the conditions relevant to teaching and learning (Euler/Hahn and Rindermann were critically appraised and synthesized into a new third model. Practical examples of teaching strategies that promote or hinder learning were compiled and added to the categories of this model and, to the extent possible, supported with empirical evidence.Based on this, a checklist with recommendations for optimizing general academic conditions was formulated.Results: The covers six categories: and These categories have been supplemented by the interests, motives and abilities of the actual teachers and students in this particular setting. The categories of this model provide the structure for a checklist in which recommendations for optimizing teaching are given.Conclusions: The checklist derived from the Frankfurt Model for ensuring quality in teaching and learning can be used for quality assurance and to improve the conditions under which teaching and learning take place in medical schools.

  1. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. Foo......, results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...

  2. THE PAR (PEER ASSESSMENT RATING CALCULATION ON 2 DIMENSIONAL TEETH MODEL IMAGE FOR THE CENTERLINE COMPONENT AND TEETH SEGMENTATION ON THE OCCLUSAL SURFACE TEETH MODEL IMAGE

    Directory of Open Access Journals (Sweden)

    Hanif Arief Wisesa

    2014-08-01

    Full Text Available Abstract The PAR (Peer Assessment Rating Index is used by orthodontists around the world to calculate the severeness of a malocclusion. A malocclusion is a dental disease where the teeth are not properly aligned. In Indonesia, the number of malocclusion is relatively high. The occurrence of orthodontics who can treat malocclusion is also low in Indonesia. In 2013, a research is done to create the telehealth monitoring system to provide better treatment of malocclusion in Indonesia. The research is further improved by using different Adaptive Multiple Thresholding methods to segmentate the image. The result will be used to calculate the Centerline component of the PAR Index. The result is a system that could calculate the PAR Index automatically and is compared to the results using manual method.

  3. Quality Management and Business Excellence

    Directory of Open Access Journals (Sweden)

    Vasile Dinu

    2017-02-01

    Full Text Available An excellent organization involves much more than the implementation and the certification of one or more models of management systems. It means developing techniques and tools of busin excellence which lead the organization to outstanding performance on quality, costs and deadlines in order to meet the expectations of all their stakeholders. Such an approach is needed especially in the context of an economy marked by globalization, extremely complex and dynamic that causes spectacular changes in the business environment by integrating quality management principles on purpose to develop sustainable excellence. Not coincidentally, the new edition of the European excellence model EFQM integrates for the first time the principle "managing with agility“ with the principles: “developing organizational capability”, “harnessing creativity & innovation”, “adding value to the customer”, “sustaining outstanding results” for the organization and “creating a sustainable future”. Also, the new model for quality management system defined by the edition from 2015 of ISO 9000 standards , promotes the process-based approach, incorporating the cycle "Plan - Do − Check − Act" (PDCA and the risk-based thinking, focusing on organizational change and innovation, in order to ensure a sustainable performance in business. Noteworthy is the endeavor for the development of a high-level structure for all international standards for management systems, aiming to harmonize these standards to facilitate the implementation of integrated management systems (quality − environment − security − social responsibility.

  4. PEER ASSESSMENT RATING (PAR INDEX CALCULATION ON 2D DENTAL MODEL IMAGE FOR OVER JET, OPEN BITE, AND TEETH SEGMENTATION ON OCCLUSION SURFACE

    Directory of Open Access Journals (Sweden)

    Muhammad Febrian Rachmadi

    2014-08-01

    Full Text Available Abstract Malocclusion is a clinical symptom, in which the teeth of maxilla and mandible are not located at the proper location. If malocclusion left untreated, it can lead to complications in the digestive system, headache, and periodontal disease disorders. Malocclusion problems involving abnormalities of teeth, bones, and muscles around the jaw are obligation of orthodontic specialists to treat them. The treatments can be varying based on the type of malocclusion, including tooth extraction and tooth braces. To know certain degree of malocclusion experienced by the patient, an assessment method called Peer Assessment Rating (PAR Index is usually used by the specialist. To help the works of orthodontic specialists in Indonesia, a new automated calculation system based on 2D image of tooth model for PAR Index is being developed. In this paper, the calculation system for over-jet, open-bite, and teeth segmentation is developed. The result of the developed system is then compared with manual assessment done by orthodontic specialist, in order to verify the accuracy of the system.

  5. A comparison of video modeling, text-based instruction, and no instruction for creating multiple baseline graphs in Microsoft Excel.

    Science.gov (United States)

    Tyner, Bryan C; Fienup, Daniel M

    2015-09-01

    Graphing is socially significant for behavior analysts; however, graphing can be difficult to learn. Video modeling (VM) may be a useful instructional method but lacks evidence for effective teaching of computer skills. A between-groups design compared the effects of VM, text-based instruction, and no instruction on graphing performance. Participants who used VM constructed graphs significantly faster and with fewer errors than those who used text-based instruction or no instruction. Implications for instruction are discussed. © Society for the Experimental Analysis of Behavior.

  6. Customer satisfaction and business excellence

    DEFF Research Database (Denmark)

    Kristensen, Kai; Martensen, Anne; Grønholdt, Lars

    The topic for this paper is the link between customer satisfaction and business performance, which makes it possible to use customer satisfaction measures as basis for creating business excellence. First, the paper presents microeconomic models for the relationship between customer satisfaction......, customer loyalty and performance, and optimal customer satisfaction is characterized which will help management choose the right quality parameters for improvement. Second, the paper describes empirical evidence that customer satisfaction measures, based on a modelling approach, have impact on economic...

  7. Thermohydraulic model of GOTHIC 8.0 for the analysis of PAR in NPP Cofrentes; Modelo termohidraulico de GOTHIC 8.0 para el analisis de PAR en C. N. Cofrentes

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, G.; Lopez-Alonso, E.; Molina, M. c.; Garcia, J.; Serrano, C.; Queral, C.; Gallego, E.

    2013-07-01

    Analysis of the installation of Passive autocatalytic recombiners in CN Cofrentes being developed by Iberdrola Engineering and Construction the support of the UPM. This analysis supports the location and size of the PAR to be installed in the containment drywell and to minimize the risks arising from the release of hydrogen generated during a severe accident and distribution of hydrogen in the containment buildings annexes.

  8. Managing for Excellence

    International Nuclear Information System (INIS)

    Gysel, T.

    2016-01-01

    Full text: Nuclear organizations now wishing to become much more effective as an organization require further advice and specific guidance, drawn from validated international best practices in the development and implementation of Knowledge Management in the context of the organization’s management system. Therefore the IAEA Nuclear Knowledge Management Section is developing an approach for implementing Knowledge Management in the context of a management system. What looks like excellence today, may not be tomorrow. Best-in-class competitors, technology, and management paradigms all evolve. Second, true Operational Excellence manifests itself through integrated performance across revenue, cost, and risk. (author

  9. Achieving excellence in training

    International Nuclear Information System (INIS)

    Mangin, A.M.; Solymossy, J.M.

    1983-01-01

    Operating a nuclear power plant is a uniquely challenging activity, requiring a high degree of competence from all who are involved. Achieving and maintaining this competence requires excellence in training. But what does excellence mean, and how do we achieve it. Based on the experience gained by INPO in plant training evaluations and accreditation activities, this paper describes some of the actions that can be taken to achieve the quality appropriate for nuclear power plant training. These actions are discussed in relation to the four phases of a performance-based training system: (1) needs analysis, (2) program design and development, (3) implementation, and (4) evaluation and improvement

  10. WAVECALC: an Excel-VBA spreadsheet to model the characteristics of fully developed waves and their influence on bottom sediments in different water depths

    Science.gov (United States)

    Le Roux, Jacobus P.; Demirbilek, Zeki; Brodalka, Marysia; Flemming, Burghard W.

    2010-10-01

    The generation and growth of waves in deep water is controlled by winds blowing over the sea surface. In fully developed sea states, where winds and waves are in equilibrium, wave parameters may be calculated directly from the wind velocity. We provide an Excel spreadsheet to compute the wave period, length, height and celerity, as well as horizontal and vertical particle velocities for any water depth, bottom slope, and distance below the reference water level. The wave profile and propagation can also be visualized for any water depth, modeling the sea surface change from sinusoidal to trochoidal and finally cnoidal profiles into shallow water. Bedload entrainment is estimated under both the wave crest and the trough, using the horizontal water particle velocity at the top of the boundary layer. The calculations are programmed in an Excel file called WAVECALC, which is available online to authorized users. Although many of the recently published formulas are based on theoretical arguments, the values agree well with several existing theories and limited field and laboratory observations. WAVECALC is a user-friendly program intended for sedimentologists, coastal engineers and oceanographers, as well as marine ecologists and biologists. It provides a rapid means to calculate many wave characteristics required in coastal and shallow marine studies, and can also serve as an educational tool.

  11. Gas Well Testing Analysis Using Finite-Difference Models and Optimization Techniques Analyse d'essais de puits de gaz par des modèles utilisant la méthode des différences finies et par des techniques d'optimisation

    Directory of Open Access Journals (Sweden)

    Darderes E. A.

    2006-11-01

    Full Text Available In reservoir engineering studies of gas fields, three important parameters are needed: the permeability-thickness product, the skin factor, and the inertial-turbulent factor. Several methods have been proposed to determine these parameters from gas well tests. The most powerful one is the pseudo-steady state analysis, where a linear dependence on a semilogarithmic plot is found between the real gas pseudo-pressure and time. Another one is the type-curve matching. Both have drawbacks because they can be rigorously applied only to specific cases. An automated type-curve match, which provides a general method to analyze well test data, is presented in this paper. It is based on the adjustment of a numerical model to gas well test data, by means of optimization techniques. The numerical model is the solution of the second order strongly non-linear partial differential equation which rules the radial flow of real gases towards a well. The differential equation is solved by finite-differences, taking into account the variation of gas properties with pressure. In order to simulate any gas well test, appropriate initial and boundary conditions are imposed. The least squares method is used to minimize residual differences between actual pressures measured during test and computed pressures. Two optimization techniques are applied to obtain the best estimate of parameters that minimize the sum of the square of the residuals: the univariate method of Fibonacci [1] and the multivariate method of Marquardt [1, 2]. This procedure is applied to a single-rate and a two-rate drawdown test. Numerical results showed excellent agreement with well test data. Les études de gisements de gaz rendent indispensables la connaissance de trois paramètres importants : la capacité de flux (produit de la perméabilité par l'épaisseur de la couche productrice, l'effet de peau et le facteur d'inertie et de turbulence. On connaît plusieurs méthodes pour déterminer ces

  12. Coping with Excellence.

    Science.gov (United States)

    Culler, Jonathan

    2002-01-01

    Suggests that when the university devotes itself to "excellence," it substitutes, for a vision of what should be taught, a contentless measure, a bureaucratic concept that extends the range of managerial control without presuming to make judgments about content. Suggests that English departments should try to design sequences of courses that are…

  13. Statistische toetsen in Excel

    NARCIS (Netherlands)

    A.A.J. van Peet; H.A. Everaert

    2007-01-01

    In KG-18 hebben we verschillende grafieken laten zien. Een veel gebruikte grafische figuur in de statistiek is de zogenaamde boxplot. Weliswaar wordt deze niet vermeld bij de standaard keuzemogelijkheden onder de Wizard Grafieken, toch is het mogelijk om deze figuur met behulp van Excel te tekenen.

  14. Use of a Microsoft Excel based add-in program to calculate plasma sinistrin clearance by a two-compartment model analysis in dogs.

    Science.gov (United States)

    Steinbach, Sarah M L; Sturgess, Christopher P; Dunning, Mark D; Neiger, Reto

    2015-06-01

    Assessment of renal function by means of plasma clearance of a suitable marker has become standard procedure for estimation of glomerular filtration rate (GFR). Sinistrin, a polyfructan solely cleared by the kidney, is often used for this purpose. Pharmacokinetic modeling using adequate software is necessary to calculate disappearance rate and half-life of sinistrin. The purpose of this study was to describe the use of a Microsoft excel based add-in program to calculate plasma sinistrin clearance, as well as additional pharmacokinetic parameters such as transfer rates (k), half-life (t1/2) and volume of distribution (Vss) for sinistrin in dogs with varying degrees of renal function. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. THE PAR (PEER ASSESSMENT RATING) CALCULATION ON 2 DIMENSIONAL TEETH MODEL IMAGE FOR THE CENTERLINE COMPONENT AND TEETH SEGMENTATION ON THE OCCLUSAL SURFACE TEETH MODEL IMAGE

    OpenAIRE

    Hanif Arief Wisesa; Ratna Rustamadji; Miesje Karmiati Purwanegara; Benny Hardjono

    2014-01-01

    Abstract The PAR (Peer Assessment Rating) Index is used by orthodontists around the world to calculate the severeness of a malocclusion. A malocclusion is a dental disease where the teeth are not properly aligned. In Indonesia, the number of malocclusion is relatively high. The occurrence of orthodontics who can treat malocclusion is also low in Indonesia. In 2013, a research is done to create the telehealth monitoring system to provide better treatment of malocclusion in Indonesia. The rese...

  16. It's quicker "Par Avignon"!

    CERN Multimedia

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  17. People management as indicator of business excellence

    DEFF Research Database (Denmark)

    Haffer, Rafal; Kristensen, Kai

    2010-01-01

    Purpose – This paper aims to show the importance of people management as a key indicator of business excellence based on four research projects, conducted on the samples of Polish (in the years 2004-2005 and 2006-2007) and Danish companies (in 1999 and 2005). Design/methodology/approach – EFQM...... it possible to compare developing Polish and developed Danish companies in their initiatives aiming at business excellence. Findings – The results indicate significant negligence in the management of human resources as one of the initiatives towards business excellence of Polish enterprises before Poland...... Excellence Model indicators were used as the evaluation criteria for the studies. The data were next estimated as a structural equation model by partial least squares using SmartPLS software. That estimation was conducted on the model of the Danish Business Excellence Index methodology. Presented data make...

  18. Numerical modeling of transferred arc melting bath heating; Modelisation numerique du chauffage de bains par arc transfere

    Energy Technology Data Exchange (ETDEWEB)

    Bouvier, A. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Trenty, L.; Guillot, J.B. [Ecole Centrale de Paris, Laboratoire EM2C. CNRS, 92 - Chatenay-Malabry (France); Delalondre, C. [Electricite de France (EDF), 78 - Chatou (France). Direction des Etudes et Recherches

    1997-12-31

    This paper presents the modeling of a transferred electric arc inside a bath of melted metal. After a recall of the context of the study, the problem of the modeling, which involves magnetohydrodynamic coupling inside the arc and the bath, is described. The equations that govern the phenomena inside the arc and the bath are recalled and the approach used for the modeling of the anode region of the arc is explained using a 1-D sub-model. The conditions of connection between arc and bath calculations are explained and calculation results obtained with a 200 kW laboratory furnace geometry are presented. (J.S.) 8 refs.

  19. La pelade par plaques

    Science.gov (United States)

    Spano, Frank; Donovan, Jeff C.

    2015-01-01

    Résumé Objectif Présenter aux médecins de famille des renseignements de base pour faire comprendre l’épidémiologie, la pathogenèse, l’histologie et l’approche clinique au diagnostic de la pelade par plaques. Sources des données Une recension a été effectuée dans PubMed pour trouver des articles pertinents concernant la pathogenèse, le diagnostic et le pronostic de la pelade par plaques. Message principal La pelade par plaques est une forme de perte pileuse auto-immune dont la prévalence durant une vie est d’environ 2 %. Des antécédents personnels ou familiaux de troubles auto-immuns concomitants, comme le vitiligo ou une maladie de la thyroïde, peuvent être observés dans un petit sous-groupe de patients. Le diagnostic peut souvent être posé de manière clinique en se fondant sur la perte de cheveux non cicatricielle et circulaire caractéristique, accompagnée de cheveux en « point d’exclamation » en périphérie chez ceux dont le problème en est aux premiers stades. Le diagnostic des cas plus complexes ou des présentations inhabituelles peut être facilité par une biopsie et un examen histologique. Le pronostic varie largement et de mauvais résultats sont associés à une apparition à un âge précoce, une perte importante, la variante ophiasis, des changements aux ongles, des antécédents familiaux ou des troubles auto-immuns concomitants. Conclusion La pelade par plaques est une forme auto-immune de perte de cheveux périodiquement observée en soins primaires. Les médecins de famille sont bien placés pour identifier la pelade par plaques, déterminer la gravité de la maladie et poser le diagnostic différentiel approprié. De plus, ils sont en mesure de renseigner leurs patients à propos de l’évolution clinique de la maladie ainsi que du pronostic général selon le sous-type de patients.

  20. DOE goals: Excellence, openness

    International Nuclear Information System (INIS)

    Isaacs, T.H.

    1989-01-01

    The author feels that the benefit of the experience and programmatic resources it has developed since passage of the Nuclear Waste Policy Act in 1982 and of the sound and flexible policy framework provided by the amendments, DOE is confident that program objectives can be met on a schedule that balances the needs for technical excellence, institutional openness, and timely acceptance. As the program evolves, DOE will continue to assess how effectively policies are serving program objectives. The need for flexibility in developing a first-of-a-kind system is essential. But flexibility does not alter the need for program stability, which, in turn, requires a commonly shared commitment to realizing the program's goals. This commitment must rest upon a pragmatic understanding of the realities of waste-management system development

  1. Reduction of thermal models of buildings: improvement of techniques using meteorological influence models; Reduction de modeles thermiques de batiments: amelioration des techniques par modelisation des sollicitations meteorologiques

    Energy Technology Data Exchange (ETDEWEB)

    Dautin, S.

    1997-04-01

    This work concerns the modeling of thermal phenomena inside buildings for the evaluation of energy exploitation costs of thermal installations and for the modeling of thermal and aeraulic transient phenomena. This thesis comprises 7 chapters dealing with: (1) the thermal phenomena inside buildings and the CLIM2000 calculation code, (2) the ETNA and GENEC experimental cells and their modeling, (3) the techniques of model reduction tested (Marshall`s truncature, Michailesco aggregation method and Moore truncature) with their algorithms and their encoding in the MATRED software, (4) the application of model reduction methods to the GENEC and ETNA cells and to a medium size dual-zone building, (5) the modeling of meteorological influences classically applied to buildings (external temperature and solar flux), (6) the analytical expression of these modeled meteorological influences. The last chapter presents the results of these improved methods on the GENEC and ETNA cells and on a lower inertia building. These new methods are compared to classical methods. (J.S.) 69 refs.

  2. Geologic modeling constrained by seismic and dynamical data; Modelisation geologique contrainte par les donnees sismiques et dynamiques

    Energy Technology Data Exchange (ETDEWEB)

    Pianelo, L.

    2001-09-01

    Matching procedures are often used in reservoir production to improve geological models. In reservoir engineering, history matching leads to update petrophysical parameters in fluid flow simulators to fit the results of the calculations with observed data. In the same line, seismic parameters are inverted to allow the numerical recovery of seismic acquisitions. However, it is well known that these inverse problems are poorly constrained. The idea of this original work is to simultaneous match both the permeability and the acoustic impedance of the reservoir, for an enhancement of the resulting geological model. To do so, both parameters are linked using either observed relations and/or the classic Wyllie (porosity impedance) and Carman-Kozeny (porosity-permeability) relationships. Hence production data are added to the seismic match, and seismic observations are used for the permeability recovery. The work consists in developing numerical prototypes of a 3-D fluid flow simulator and a 3-D seismic acquisition simulator. Then, in implementing the coupled inversion loop of the permeability and the acoustic impedance of the two models. We can hence test our theory on a 3-D realistic case. Comparison of the coupled matching with the two classical ones demonstrates the efficiency of our method. We reduce significantly the number of possible solutions, and then the number of scenarios. In addition to that, the augmentation of information leads to a natural improvement of the obtained models, especially in the spatial localization of the permeability contrasts. The improvement is significant, at the same time in the distribution of the two inverted parameters, and in the rapidity of the operation. This work is an important step in a way of data integration, and leads to a better reservoir characterization. This original algorithm could also be useful in reservoir monitoring, history matching and in optimization of production. This new and original method is patented and

  3. Methode de conception dirigee par les modeles pour les systemes avioniques modulaires integres basee sur une approche de cosimulation

    Science.gov (United States)

    Bao, Lin

    In the aerospace industry, with the development of avionic systems becomes more and more complex, the integrated modular avionics (IMA) architecture was proposed to replace its predecessor - the federated architecture, in order to reduce the weight, power consumption and the dimension of the avionics equipment. The research work presented in this thesis, which is considered as a part of the research project AVIO509, aims to propose to the aviation industry a set of time-effective and cost-effective solutions for the development and the functional validation of IMA systems. The proposed methodologies mainly focus on two design flows that are based on: 1) the concept of model-driven engineering design and 2) a cosimulation platform. In the first design flow, the modeling language AADL is used to describe the IMA architecture. The environment OCARINA, a code generator initially designed for POK, was modified so that it can generate avionic applications from an AADL model for the simulator SIMA (an IMA simulator compliant to the ARINC653 standards). In the second design flow, Simulink is used to simulate the external world of IMA module thanks to the availability of avionic library that can offer lots of avionics sensors and actuators, and as well as its effectiveness in creating the Simulink models. The cosimulation platform is composed of two simulators: Simulink for the simulation of peripherals and SIMA for the simulation of IMA module, the latter is considered as an ideal alternative for the super expensive commercial development environment. In order to have a good portability, a SIMA partition is reserved as the role of " adapter " to synchronize the communication between these two simulators via the TCP/IP protocol. When the avionics applications are ported to the implementation platform (such as PikeOS) after the simulation, there is only the " adapter " to be modified because the internal communication and the system configuration are the same. An avionics

  4. The math excellence workshop

    International Nuclear Information System (INIS)

    Lasser, Susan J.S.; Snelsire, Robert W.

    1992-01-01

    This paper describes the first two years of the Clemson University College of Engineering's Math Excellence Workshop, a program administered by Westinghouse Electric Corporation, Savannah River Site, and funded by the Department of Energy. The objective of the program is to prepare minority students for technical/scientific study, with the goal of increasing minority retention in the College of Engineering, Twenty-three African American students, all of whom had been accepted into the College of Engineering Fall 1990 freshman class, took part in the first year of the program. The contract paid for room, board, tuition, fees, books, and supplies for the students to live on campus and take a precalculus math course. In addition, the students attended a special honors workshop designed to prepare them to study technical material effectively. Twenty of the 23 students earned As or Bs in the precalculus class. All participants indicated that they felt confident of their ability to succeed academically at Clemson. At the end of the session, twenty of the students were still planning to major in engineering. The program was repeated the following summer with 24 students from the 1991 freshman class. Twelve of the students earned A's or B's in the precalculus class. (author)

  5. The math excellence workshop

    Energy Technology Data Exchange (ETDEWEB)

    Lasser, Susan J.S.; Snelsire, Robert W [College of Engineering, Clemson University, Clemson, SC (United States)

    1992-07-01

    This paper describes the first two years of the Clemson University College of Engineering's Math Excellence Workshop, a program administered by Westinghouse Electric Corporation, Savannah River Site, and funded by the Department of Energy. The objective of the program is to prepare minority students for technical/scientific study, with the goal of increasing minority retention in the College of Engineering, Twenty-three African American students, all of whom had been accepted into the College of Engineering Fall 1990 freshman class, took part in the first year of the program. The contract paid for room, board, tuition, fees, books, and supplies for the students to live on campus and take a precalculus math course. In addition, the students attended a special honors workshop designed to prepare them to study technical material effectively. Twenty of the 23 students earned As or Bs in the precalculus class. All participants indicated that they felt confident of their ability to succeed academically at Clemson. At the end of the session, twenty of the students were still planning to major in engineering. The program was repeated the following summer with 24 students from the 1991 freshman class. Twelve of the students earned A's or B's in the precalculus class. (author)

  6. Optimizing Air Transportation Service to Metroplex Airports. Par 2; Analysis Using the Airline Schedule Optimization Model (ASOM)

    Science.gov (United States)

    Donoue, George; Hoffman, Karla; Sherry, Lance; Ferguson, John; Kara, Abdul Qadar

    2010-01-01

    The air transportation system is a significant driver of the U.S. economy, providing safe, affordable, and rapid transportation. During the past three decades airspace and airport capacity has not grown in step with demand for air transportation; the failure to increase capacity at the same rate as the growth in demand results in unreliable service and systemic delay. This report describes the results of an analysis of airline strategic decision-making that affects geographic access, economic access, and airline finances, extending the analysis of these factors using historic data (from Part 1 of the report). The Airline Schedule Optimization Model (ASOM) was used to evaluate how exogenous factors (passenger demand, airline operating costs, and airport capacity limits) affect geographic access (markets-served, scheduled flights, aircraft size), economic access (airfares), airline finances (profit), and air transportation efficiency (aircraft size). This analysis captures the impact of the implementation of airport capacity limits, as well as the effect of increased hedged fuel prices, which serve as a proxy for increased costs per flight that might occur if auctions or congestion pricing are imposed; also incorporated are demand elasticity curves based on historical data that provide information about how passenger demand is affected by airfare changes.

  7. ASPIRE-to-Excellence Academy

    Directory of Open Access Journals (Sweden)

    Simon Drees

    2016-07-01

    Full Text Available The ASPIRE-to-Excellence Academy was recently founded at the 2015 Association for Medical Education in Europe (AMEE conference in Glasgow. The academy is new pillar of the ASPIRE-to-Excellence initiative by AMEE, which aims at promoting and encouraging medical schools in achieving excellence in the categories of assessment, student engagement, social accountability or faculty development. The Academy panel consists of the members of the ASPIRE Board and representatives from schools which have been recognised with an ASPIRE-to-excellence award in one or more of the categories. Major goal of the ASPIRE-to-Excellence Academy is to foster collaboration between excellent medical schools and to allow them to exchange experiences and Best Practices. The Academy members are organising workshops and symposia at international conferences to inform medical schools about the ASPIRE-to-Excellence programme and the areas for recognition in excellence as well as to support medical school in preparing their applications.

  8. suPAR

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Giamarellos-Bourboulis, Evangelos J

    2015-01-01

    Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most...... promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents...

  9. Idea of Quality Versus Idea of Excellence

    Directory of Open Access Journals (Sweden)

    Marko Kiauta

    2012-12-01

    Full Text Available This study investigates professionals on the field of quality, are responsible to give to customer honest clarification of fundamental ideas. Quality movement is losing credibility with suggesting that the idea of quality is replacing with the idea of excellence. Findings are based on more than 25 years of practice in professional promotion of quality: in consulting on private and public sector, from 1990 lead auditor at SIQ (Slovenian Institute of Quality, from 1998 lead assessor – commission for Slovenian Excellence Quality Award. Theory is developed based on: Noriaki Kano theory of Attractive quality, Tito Conti ideas on TQM and applications problems of Excellence model, Practical case of General Hospital Novo Mesto (in 1998 first attempt of using EM, than forced to build QMS based on ISO 9001 and then returned to practice EM. Findings: We really need to amplify and to understand the concept of quality in a much wider way. To treat excellence related activities separated from all others quality management activities is not god solution. The name of EFQM Excellence Model should be replaced with Quality Management Model. Research limitations/implications: This paper present findings mainly based on practice in Slovenia and especially in public sector where practicing of CAF is not giving expected benefits. Practical implications: The three styles of quality management (improvements to reach demands, improvements to reach expectations, improvements to react on new conditions and needs should be connected with personal development. Theory is developed based on: Noriaki Kano theory of Attractive quality, Tito Conti ideas on TQM and applications problems of Excellence model. We need integration moments. Integration is other word for creativity and health. It leads to integrity. Excellence is only one of three states of quality. If we ask: How? The answer is bad, good or excellent. All three are possible states of the same parameter.

  10. Parálisis cerebral :

    OpenAIRE

    Cabrero Izquierdo, María del Carmen

    2012-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  11. Leprosy New Case Detection Trends and the Future Effect of Preventive Interventions in Pará State, Brazil: A Modelling Study

    NARCIS (Netherlands)

    H.J. de Matos (Haroldo José); D.J. Blok (David); S.J. de Vlas (Sake); J.H. Richardus (Jan Hendrik)

    2016-01-01

    textabstractBackground: Leprosy remains a public health problem in Brazil. Although the overall number of new cases is declining, there are still areas with a high disease burden, such as Pará State in the north of the country. We aim to predict future trends in new case detection rate (NCDR) and

  12. Contribution of Lean Management to Excellence

    Directory of Open Access Journals (Sweden)

    López-Fresno Palmira

    2014-11-01

    Full Text Available To continuously and systematically improve efficiency and efficacy of processes, organizations need the implication of all employees in continuous improvement and innovation through suitable Quality Management Programs (QMPs. Effectiveness of these programs is directly linked to the requirement employees understand the methodologies and tools used for QM and the benefits that will derivate from their implementation, individually and collectively, so they can commit and implicate. Lean Management is a friendly methodology to continuously and systematically achieve process improvement, so helping the organization seeking operational excellence that contributes to overall excellence. This paper identifies Critical Success Factors (CSFs for an effective implementation of QMPs, suggests Lean Management as an easy-to-understand, powerful and friendly methodology for operational excellence and overall excellence, and presents a case experience of implementation of Lean Management in a health care organization that applies the EFQM model, and the lessons learnt.

  13. Modelagem hidrológica determinística e estocástica aplicada à região hidrográfica do Xingu- Pará Deterministic and stochastic hydrological modeling applied to the Xingu river basin - Pará

    Directory of Open Access Journals (Sweden)

    Edmundo Wallace Monteiro Lucas

    2009-09-01

    Full Text Available A modelagem hidrológica é uma importante ferramenta no planejamento e gerenciamento de programas de recursos hídricos de bacias hidrográficas. Neste trabalho, foi aplicado o modelo hidrológico determinístico mensal de dois parâmetros e o modelo estocástico, ARIMA, para simular a vazão mensal das sub-bacias da região hidrográfica do Xingu no Estado do Pará. O objetivo principal foi simular a vazão mensal através dos modelos e comparar os seus resultados. O modelo hidrológico determinístico aplicado possui uma estrutura simples e apresentou bons resultados, porém mostrou-se muito sensível a eventos extremos de precipitação. O modelo estocástico ARIMA, conseguiu capturar a dinâmica das séries temporais, apresentando resultados muito satisfatórios na simulação da vazão mensal nas estações da bacia. Ambos os modelos devem ser aplicados com cautela no período chuvoso, onde ocorrem os eventos extremos de precipitação e consequentemente vazões de pico.Hydrologic modeling is an important tool for the planning and management of water resources use in river basins. In this work, a two-parameter monthly deterministic hydrologic model and the stochastic model, ARIMA, were applied to simulate the monthly runoff of the Xingu river basin in the State of Pará. The main objective of this work is to simulate the monthly runoff using the two models and to compare their results. The applied hydrological deterministic model has a simple structure and presented good results, but seems to be very sensitive to extreme precipitation events. The stochastic model ARIMA was able to capture the dynamic of the temporal series, presenting very satisfactory results for the simulation of the monthly runoff at the basin stations. Both models should be applied with caution during the rainy season, when extreme precipitation events and consequently peaks of runoff occur.

  14. Learn Excel 2011 for Mac

    CERN Document Server

    Hart-Davis, Guy

    2011-01-01

    Microsoft Excel 2011 for Mac OS X is a powerful application, but many of its most impressive features can be difficult to find. Learn Excel 2011 for Mac by Guy Hart-Davis is a practical, hands-on approach to learning all of the details of Excel 2011 in order to get work done efficiently on Mac OS X. From using formulas and functions to creating databases, from analyzing data to automating tasks, you'll learn everything you need to know to put this powerful application to use for a variety of tasks. What you'll learn * The secrets of the Excel for Mac interface! * How to create effective workbo

  15. Excel data analysis for dummies

    CERN Document Server

    Nelson, Stephen L

    2014-01-01

    Harness the power of Excel to discover what your numbers are hiding Excel Data Analysis For Dummies, 2nd Edition is the ultimate guide to getting the most out of your data. Veteran Dummies author Stephen L. Nelson guides you through the basic and not-so-basic features of Excel to help you discover the gems hidden in your rough data. From input, to analysis, to visualization, the book walks you through the steps that lead to superior data analysis. Excel is the number-one spreadsheet application, with ever-expanding capabilities. If you're only using it to balance the books, you're missing out

  16. Excel VBA 24-hour trainer

    CERN Document Server

    Urtis, Tom

    2015-01-01

    Master VBA automation quickly and easily to get more out of Excel Excel VBA 24-Hour Trainer, 2nd Edition is the quick-start guide to getting more out of Excel, using Visual Basic for Applications. This unique book/video package has been updated with fifteen new advanced video lessons, providing a total of eleven hours of video training and 45 total lessons to teach you the basics and beyond. This self-paced tutorial explains Excel VBA from the ground up, demonstrating with each advancing lesson how you can increase your productivity. Clear, concise, step-by-step instructions are combined wit

  17. Teaching physics using Microsoft Excel

    Science.gov (United States)

    Uddin, Zaheer; Ahsanuddin, Muhammad; Khan, Danish Ahmed

    2017-09-01

    Excel is both ubiquitous and easily understandable. Most people from every walk of life know how to use MS office and Excel spreadsheets. Students are also familiar with spreadsheets. Most students know how to use spreadsheets for data analysis. Besides basic use of Excel, some important aspects of spreadsheets are highlighted in this article. MS Excel can be used to visualize effects of various parameters in a physical system. It can be used as a simulating tool; simulation of wind data has been done through spreadsheets in this study. Examples of Lissajous figures and a damped harmonic oscillator are presented in this article.

  18. His Excellency Mr Farukh Amil

    CERN Multimedia

    hugho, Chemli

    2017-01-01

    His Excellency Mr Farukh Amil Ambassador Extraordinary and Plenipotentiary Permanent Representative of the Islamic Republic of Pakistan to the United Nations Office and other international organisations in Geneva

  19. Challenges to Business Excellence: Some Empirical Evidence

    Directory of Open Access Journals (Sweden)

    Brown Alan

    2014-11-01

    Full Text Available The business excellence models are used by many organisations around the world as a strategic driver for business improvement and in some cases as the basis for applications for awards based on the models. These include the Baldrige, EFQM, Australian Business Excellence Framework and many other national and regional models. Whilst many award recipients showcase their achievements, comparatively little is known about the challenges and impediments they face in reaching and sustaining high levels of success as evidenced by winning awards. This paper seeks to identify challenges faced by examining the experience of a sample of Australian Business Excellence Award winners. Findings suggest that the primary challenges include; leadership support, drive and consistency throughout the organisation and communicating strategy and making it meaningful for people at all levels. The study also found variability in challenges across organisations.

  20. ARS-Media for Excel

    Science.gov (United States)

    ARS-Media for Excel is an ion solution calculator that uses Microsoft Excel to generate recipes of salts for complex ion mixtures specified by the user. Generating salt combinations (recipes) that result in pre-specified target ion values is a linear programming problem. Thus, the recipes are genera...

  1. The Strategic Study of National Quality Award through Business Excellence Model - The IBM, Panasonic and E.SUN Bank Cases in Taiwan

    Directory of Open Access Journals (Sweden)

    Jang-Ruey Tzeng

    2009-10-01

    Full Text Available Quality is a dignity to a country and also masterpiece and bedrock for the development of a country. To recover economical prosperity immediately right from the II world war, Japan founded Demin Quality Award to encourage the improvement of quality and promote the whole scale of competence core for enterprises in 1951. All the products produced by Japan are entirely favoured by the customers around the world during the period of 1975. The Japanese made automobiles, electronics and appliances are inexpensive and competitive enough to sluggish the economy growth of USA. To counter the serious threats and regain the advantage of the market, the United States finally founded Malcolm Baldrige National Quality Award, MBNQA to provide a series of standards for excellence performance in 1987. European Excellence Award was set up by the European Foundation for Quality Management, EFQM for advancing the superiority of tech development in 1991. Among the developing countries, there is no exception can be made for the emerging countries, especially in area of Aisa. Taiwan is the first country in Asia to establish Taiwan National Quality Award, TNQA in 1990 to represent the great honour of quality, also the first national quality award in this area. As the candidate with the great potential to be developed country in this region, not only Taiwan is struggling to advance its technology, but also promote the quality issues by quality related policies of government. Therefore, this paper is to examine the process of involvement in the promotion to Taiwan National Quality Award for three different enterprises, the 1assessment of various dimension in company through spot visit by judges of TNQA, and the analysis of interview record from the superior executives for the further research and introductive contribution of this award. Conclusively, this paper is trying to draw the overview of how to improve the excellence of quality in the practice of business

  2. Teach yourself visually complete Excel

    CERN Document Server

    McFedries, Paul

    2013-01-01

    Get the basics of Excel and then go beyond with this new instructional visual guide While many users need Excel just to create simple worksheets, many businesses and professionals rely on the advanced features of Excel to handle things like database creation and data analysis. Whatever project you have in mind, this visual guide takes you step by step through what each step should look like. Veteran author Paul McFedries first presents the basics and then gradually takes it further with his coverage of designing worksheets, collaborating between worksheets, working with visual data

  3. Predicting the distribution of a parasite using the ecological niche model, GARP Predicción de la distribución de un parásito usando el modelo de nicho ecológico, GARP

    Directory of Open Access Journals (Sweden)

    Terry R. Haverkost

    2010-12-01

    Full Text Available The ecological niche of a parasite exists only at the nexus of certain abiotic and biotic conditions suitable for both the definitive and intermediate hosts. However, the life cycles of most parasites are not known, or are poorly known, and using known ranges of hosts to find endemic parasitic infections has been difficult. However, with ecological niche modeling, we can create potential range maps using known localities of infection. Testing the validity of such maps requires knowledge of the localities of other parasites with common history. Here, we find that the ecological niche of a tapeworm parasite of voles, Paranoplocephala macrocephala (Cestoda: Anoplocephalidae, allows prediction of the presence (in ecological and geographic space of 19 related parasite species from 3 genera in 23 different hosts throughout the Nearctic. These results give credence to the idea that this group shares similar life cycle requirements despite phylogenetic distance. This work further validates ecological niche modeling as a means by which to predict occurrence of parasites when not all facets of the life cycle are confirmed. Such inductive methods create the opportunity for deducing potential reservoir or intermediate hosts, and complementing studies of parasite biodiversity and community ecology.El nicho ecológico de un parásito existe sólo cuando coinciden condiciones abióticas y bióticas necesarias para los hospederos definitivos e intermediarios. No obstante, los ciclos de vida de la mayoría de los parásitos son poco conocidos; el usar áreas de distribución de hospederos para encontrar áreas endémicas de parasitismo ha resultado difícil. Con el modelado de nicho, se pueden producir mapas del área de distribución potencial con base en sitios conocidos de presencia. Para probar la validez de estos mapas, se requiere el conocimiento de sitios de presencia de otros parásitos relacionados. En este estudio, encontramos que el nicho ecol

  4. Simulation of recent and future climates using CNRM and IPSL models; Simulation du climat recent et futur par les modeles du CNRM et de l'IPSL

    Energy Technology Data Exchange (ETDEWEB)

    Dufresne, J.L.; Bony, S.; Fairhead, L.; Grandpeix, J.Y.; Hourdin, F.; Idelkadi, A.; Musat, I. [Universite Pierre et Marie Curie, Lab. de Meteorologie Dynamique (LMD-IPSL), CNRS, 75 - Paris (France); Salas y Melia, D.; Tyteca, S.; Chauvin, F.; Deque, M.; Douville, H.; Gueremy, J.F.; Marquet, P.; Planton, S.; Royer, J.F.; Voldoire, A. [Meteo France Centre National de Recherches Meteorologiques, 31 - Toulouse (France); Denvil, S.; Cadule, P.; Foujols, M.A. [Universite Pierre et Marie Curie, Institut Pierre-Simon Laplace, CNRS, 75 - Paris (France); Arzel, O.; Fichefet, T. [Universite Catholique de Louvain (UCL), Louvain-la-Neuve (Belgium). Inst. d' Astronomie et de Geophysique G. Lemaitre; Braconnot, P.; Brockmann, P.; Caubel, A.; Friedlingstein, P.; Marti, O.; Swingedouw, D. [Laboratoire des Sciences du Climat et de l' Environnement, Domaine du CNRS, 91 - Gif Sur Yvette (France); Krinner, G. [Universite Joseph-Fourier, Grenoble I, Lab. de Glaciologie et Geophysique de l' Environnement (LGGE), CNRS, 38 - Saint Martin d' Heres (France); Levy, C.; Madec, G. [Universite Pierre et Marie Curie, Lab. d' Oceanographie et Climat (Locean-IPLS), CNRS, 75 - Paris (France)

    2006-11-15

    In support of the Fourth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) that should appear in early 2007, modelling groups world-wide have performed a huge coordinated exercise of climate change runs for the 20. and 21. centuries. In this paper we present the results of the two French climate models, CNRM and IPSL. In particular we emphasize the progress made since the previous IPCC report and we identify which results are comparable among models and which strongly differ. (authors)

  5. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....

  6. The Building Resiliency and Vocational Excellence (BRAVE) Program: a violence-prevention and role model program for young, African American males.

    Science.gov (United States)

    Griffin, James P

    2005-11-01

    There are sharp disparities between non-Hispanic Whites and African Americans in mortality and years of potential life lost for numerous health-related conditions, including HIV/AIDS. The Building Resiliency and Vocational Excellence (BRAVE) Program is an intervention using Resiliency Networking designed for use with African American young men to help offset these disparities. Resiliency Networking incorporates coaching, career planning, and re-definition of gender roles to help young men develop a sense of purpose and future and to manage their lifestyles effectively. In addition to fostering a strong link with an older mentor, the program fosters healthy peer-to-peer relationships. The paper reports on preliminary use of the intervention and recommends future applications.

  7. Synthesis of zirconium by zirconium tetrachloride reduction by magnesio-thermia. Experimental study and modelling; Elaboration de zirconium par reduction de tetrachlorure de zirconium par magnesothermie. Etude experimentale et modelisation

    Energy Technology Data Exchange (ETDEWEB)

    Basin, N

    2001-01-01

    This work deals with the synthesis of zirconium. The ore is carbo-chlorinated to obtain the tetrachloride which is then purified by selective condensation and extractive distillation. Zirconium tetrachloride is then reduced by magnesium and the pseudo-alloy is obtained according to the global following reaction (Kroll process): ZrCl{sub 4} + 2 Mg = 2 MgCl{sub 2}. By thermodynamics, it has been shown that the volatilization of magnesium chloride and the formation of zirconium sub-chlorides are minimized when the combined effects of temperature and of dilution with argon are limited. With these conditions, the products, essentially zirconium and magnesium chloride, are obtained in equivalence ratio in the magnesio-thermia reaction. The global kinetics of the reduction process has been studied by a thermal gravimetric method. A thermo-balance device has been developed specially for this kinetics study. It runs under a controlled atmosphere and is coupled to a vapor tetrachloride feed unit. The transformation is modelled supposing that the zirconium and magnesium chloride formation result: 1)of the evaporation of magnesium from its liquid phase 2)of the transfer of magnesium and zirconium tetrachloride vapors towards the front of the reaction located in the gaseous phase 3)of the chemical reaction. In the studied conditions, the diffusion is supposed to be the limiting process. The influence of the following parameters: geometry of the reactive zone, temperature, scanning rate of the argon-zirconium tetrachloride mixture, composition of the argon-zirconium tetrachloride mixture has been experimentally studied and confronted with success to the model. (O.M.)

  8. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  9. Par Pond vegetation status 1996

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-12-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  10. Study of the two-dimensional Hubbard model at half-filling through constructive methods; Etude du modele de Hubbard bidimensionnel a demi remplissage par des methodes constructives

    Energy Technology Data Exchange (ETDEWEB)

    Afchain, St

    2005-02-15

    The Hubbard model is the simplest model to describe the behaviour of fermions on a network, it takes into account only fermion scattering and only interactions with other fermions located on the same site. Half-filling means that the total number of fermions is equal to half the number of sites. In the first chapter we show how we can pass trough successive approximations from a very general Hamiltonian to the Hubbard Hamiltonian. The second chapter is dedicated to the passage from the Hamiltonian formalism to the Grassmanian functional formalism. The main idea is to show that the correlation functions of the Hamiltonian approach can be described through fermionic functional integrals which implies the possibility of speaking of the model in terms of field theory. The chapter 3 deals with the main constructive techniques that allow the strict and consistent construction of models inside the frame of field theory. We show by proving the violation of a condition concerning self-energy, that the two-dimensional Hubbard model at half-filling has not the behaviour of a Fermi liquid in the Landau's interpretation. (A.C.)

  11. ARS-Media for excel instruction manual

    Science.gov (United States)

    ARS-Media for Excel Instruction Manual is the instruction manual that explains how to use the Excel spreadsheet ARS-Media for Excel application. ARS-Media for Excel Instruction Manual is provided as a pdf file....

  12. PARs for combustible gas control in advanced light water reactors

    International Nuclear Information System (INIS)

    Hosler, J.; Sliter, G.

    1997-01-01

    This paper discusses the progress being made in the United States to introduce passive autocatalytic recombiner (PAR) technology as a cost-effective alternative to electric recombiners for controlling combustible gas produced in postulated accidents in both future Advanced Light Water Reactors (ALWRs) and certain U. S. operating nuclear plants. PARs catalytically recombine hydrogen and oxygen, gradually producing heat and water vapor. They have no moving parts and are self-starting and self-feeding, even under relatively cold and wet containment conditions. Buoyancy of the hot gases they create sets up natural convective flow that promotes mixing of combustible gases in a containment. In a non-inerted ALWR containment, two approaches each employing a combination of PARs and igniters are being considered to control hydrogen in design basis and severe accidents. In pre-inerted ALWRs, PARs alone control radiolytic oxygen produced in either accident type. The paper also discusses regulatory feedback regarding these combustible gas control approaches and describes a test program being conducted by the Electric Power Research Institute (EPRI) and Electricite de France (EdF) to supplement the existing PAR test database with performance data under conditions of interest to U.S. plants. Preliminary findings from the EPRI/EdF PAR model test program are included. Successful completion of this test program and confirmatory tests being sponsored by the U. S. NRC are expected to pave the way for use of PARs in ALWRs and operating plants. (author)

  13. Study of the permeability up-scaling by direct filtering of geostatistical model; Etude du changement d'echelle des permeabilites par filtrage direct du modele geostatistique

    Energy Technology Data Exchange (ETDEWEB)

    Zargar, G

    2005-10-15

    In this thesis, we present a new approach, which consists in directly up-scaling the geostatistical permeability distribution rather than the individual realizations. Practically, filtering techniques based on. the FFT (Fast Fourier Transform), allows us to generate geostatistical images, which sample the up-scaled distributions. In the log normal case, an equivalence hydraulic criterion is proposed, allowing to re-estimate the geometric mean of the permeabilities. In the anisotropic case, the effective geometric mean becomes a tensor which depends on the level of filtering used and it can be calculated by a method of renormalisation. Then, the method was generalized for the categorial model. Numerical tests of the method were set up for isotropic, anisotropic and categorial models, which shows good agreement with theory. (author)

  14. Study of the permeability up-scaling by direct filtering of geostatistical model; Etude du changement d'echelle des permeabilites par filtrage direct du modele geostatistique

    Energy Technology Data Exchange (ETDEWEB)

    Zargar, G.

    2005-10-15

    In this thesis, we present a new approach, which consists in directly up-scaling the geostatistical permeability distribution rather than the individual realizations. Practically, filtering techniques based on. the FFT (Fast Fourier Transform), allows us to generate geostatistical images, which sample the up-scaled distributions. In the log normal case, an equivalence hydraulic criterion is proposed, allowing to re-estimate the geometric mean of the permeabilities. In the anisotropic case, the effective geometric mean becomes a tensor which depends on the level of filtering used and it can be calculated by a method of renormalisation. Then, the method was generalized for the categorial model. Numerical tests of the method were set up for isotropic, anisotropic and categorial models, which shows good agreement with theory. (author)

  15. Phases and Actions of the Evolution of the Concept of Quality in Canada and Australia – A Theoretical Modelling of the Development of Knowledge in Business Performance in the XXI Century - The Approach to Excellence

    Directory of Open Access Journals (Sweden)

    Cristina Raluca Popescu

    2015-05-01

    Full Text Available In the paper “Phases and Actions of the Evolution of the Concept of Quality in Canada and Australia – A Theoretical Modelling of the Development of Knowledge in Business Performance in the XXI Century - The Approach to Excellence” the authors present the basic features of the phases and actions of the evolution of the concept of quality in Canada and Australia, as a theoretical modelling of the development of knowledge in business performance in the XXI century in order to improve the organizational processes so that excellence can be achieved.

  16. Validity of the electrical model representation of the effects of nuclear magnetic resonance (1961); Validite de la representation par modele electrique des effets de resonance magnetique nucleaire (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet, G [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1961-07-01

    When studying the behaviour of a magnetic resonance transducer formed by the association of an electrical network and of a set of nuclear spins, it is possible to bring about a representation that is analytically equivalent by means of an entirely electrical model, available for transients as well as steady-state. A detailed study of the validity conditions justifies its use in most cases. Also proposed is a linearity criterion of Bloch's equations in transient state that is simply the prolongation of the well-known condition of non-saturation in the steady-state. (author) [French] L'etude du comportement d'un transducteur a resonance magnetique forme de l'association d'un reseau electrique et d'un ensemble de noyaux dotes de spin, montre qu'il est possible d'en deduire une representation analytiquement equivalente au moyen d'un modele entierement electrique utilisable pour un regime transitoire aussi bien que pour un regime permanent. Une etude detaillee des conditions de validite permet d'en justifier l'emploi dans la majorite des cas. On propose enfin un critere de linearite des equations de Bloch en regime transitoire, qui constitue un prolongement de la condition connue de non-saturation en regime stationnaire. (auteur)

  17. Developing talent for operational excellence.

    Science.gov (United States)

    Theadore, Jason C; O'Brien, Thaddeus J

    2012-01-01

    Many organizations have the expectation that their employees will prepare for their own professional development without much support or guidance. To achieve operational excellence, development of the people in an organization is just as important as the development of technologies and processes. Ohio Health Ambulatory Division in Columbus, OH created a plan to develop its people systematically in three distinct pillars: management development, staff engagement, and clinical excellence. Much was learned about talent development since work began on "The People Plan", perhaps the most critical lesson learned has been the importance of not giving up on the effort.

  18. Peptide-Based Optical uPAR Imaging for Surgery

    DEFF Research Database (Denmark)

    Juhl, Karina; Christensen, Anders; Persson, Morten

    2016-01-01

    Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical...... tumor resection. In the present study, a new uPAR-targeted fluorescent probe was developed and the in vivo applicability was evaluated in a human xenograft mouse model. Most human carcinomas express high level of uPAR in the tumor-stromal interface of invasive lesions and uPAR is therefore considered...... an ideal target for intra-operative imaging. Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. For in vivo testing, human glioblastoma xenograft...

  19. Automating Partial Period Bond Valuation with Excel's Day Counting Functions

    Science.gov (United States)

    Vicknair, David; Spruell, James

    2009-01-01

    An Excel model for calculating the actual price of bonds under a 30 day/month, 360 day/year day counting assumption by nesting the DAYS360 function within the PV function is developed. When programmed into an Excel spreadsheet, the model can accommodate annual and semiannual payment bonds sold on or between interest dates using six fundamental…

  20. Patient satisfaction: focusing on "excellent".

    Science.gov (United States)

    Otani, Koichiro; Waterman, Brian; Faulkner, Kelly M; Boslaugh, Sarah; Burroughs, Thomas E; Dunagan, W Claiborne

    2009-01-01

    In an emerging competitive market such as healthcare, managers should focus on achieving excellent ratings to distinguish their organization from others. When it comes to customer loyalty, "excellent" has a different meaning. Customers who are merely satisfied often do not come back. The purpose of this study was to find out what influences adult patients to rate their overall experience as "excellent." The study used patient satisfaction data collected from one major academic hospital and four community hospitals. After conducting a multiple logistic regression analysis, certain attributes were shown to be more likely than others to influence patients to rate their experiences as excellent. The study revealed that staff care is the most influential attribute, followed by nursing care. These two attributes are distinctively stronger drivers of overall satisfaction than are the other attributes studied (i.e., physician care, admission process, room, and food). Staff care and nursing care are under the control of healthcare managers. If improvements are needed, they can be accomplished through training programs such as total quality management or continuous quality improvement, through which staff employees and nurses learn to be sensitive to patients' needs. Satisfying patients' needs is the first step toward having loyal patients, so hospitals that strive to ensure their patients are completely satisfied are more likely to prosper.

  1. Leadership, excellence, creativity and innovation

    OpenAIRE

    Coulson-Thomas, Colin

    2016-01-01

    Raises questions about the meaning, purpose and practice of contemporary leadership in relation to excellence, creativity and innovation, covering leadership qualities, the context and requirements of leadership, leadership at different stages of development, creativity and innovation, CEOs and top down leadership, entrepreneurship and shared leadership, leading the network organisation, shared and collective leadership, the role and contribution of boards, key questions for boards, leadershi...

  2. Managing Excellence in Sports Performance.

    Science.gov (United States)

    Lyle, John W. B.

    1997-01-01

    Conceptualizes excellence in sports performance and suggests that there is a failure to distinguish between community recreation and performance sports as well as lack of knowledge about talent identification. Proposes a structure for management and investment in education and training in the field. (SK)

  3. Understanding Research Excellence at IDRC

    International Development Research Centre (IDRC) Digital Library (Canada)

    KFerguson

    2009-01-18

    Jan 18, 2009 ... The primary intended users of this study are IDRC program staffand the ... type of framework, and some parameters that anchor the concepts.” ... (e.g., the complex health care delivery system), we have little reason to ..... defines or views research excellence and related concepts such as rigor and impact;.

  4. Proteinase-Activated Receptor 1 (PAR1 regulates leukemic stem cell functions.

    Directory of Open Access Journals (Sweden)

    Nicole Bäumer

    Full Text Available External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  5. Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

    Science.gov (United States)

    Bäumer, Nicole; Krause, Annika; Köhler, Gabriele; Lettermann, Stephanie; Evers, Georg; Hascher, Antje; Bäumer, Sebastian; Berdel, Wolfgang E; Müller-Tidow, Carsten; Tickenbrock, Lara

    2014-01-01

    External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  6. Vote par sondage uniforme incorruptible

    OpenAIRE

    Blanchard , Nicolas

    2016-01-01

    International audience; Introduit en 2012 par David Chaum, le vote par sondage uniforme (random-sample voting) est un protocole de vote basé sur un choix d'une sous-population représentative , permettant de limiter les coûts tout en ayant de nombreux avantages, principalement lorsqu'il est couplé a d'autres techniques comme ThreeBallot. Nous analysons un problème de corruptibilité potentielle où les votants peuvent vendre leur vote au plus offrant et proposons une variation du protocole reméd...

  7. Confidant par excellence, advisors and healers: women traders' intersecting identities and roles in Senegal.

    Science.gov (United States)

    Lo, Marieme S

    2013-01-01

    Characteristics associated with West African women traders often hinge on their resilience, ingenuity and savvy business practices under precarious economic conditions and changing ecologies. Moreover, traders are defined, identified and classified by their trade and the commodities associated with their trading practice. However, a social analysis and ethnography of trading practices challenges this taxonomy and suggests the relational and social embeddedness of such economic transactions and the unexpected intersecting roles traders perform as confidants, advisers and healers. This paper examines the multiple roles that Senegalese traders embody and perform and the vast repertoire of knowledge and cultural registers they employ as advisers on sexuality, matrimonial affairs and conjugality. It posits to reframe trade and the marketplace, not only as a fulcrum of economic transaction, but also as locus of affective interactions, performative-counselling practices and fluid space where traders impart knowledge to their female clientele on a wide spectrum of issues such as sexuality, conjugality and the aesthetics of intimacy. Lastly, it seeks to unveil new analytics and theorising on the evolving, embodied and performative roles of women traders and market women, while proving contextual and culturally-textured insights on 'counselling' and its interpretation in Senegal.

  8. Digestive ripening: a synthetic method par excellence for core–shell ...

    Indian Academy of Sciences (India)

    persity of nanoparticles. An even more remarkable feature of digestive ripening exemplified here is, it could be exercised as a synthetic method towards vari- ous heterostructured materials like core–shell particles, nanoalloys, and nanocomposites in combination with the synthetic method, solvated metal atom dispersion.

  9. Performance Analysis of Compositional and Modified Black-Oil Models For a Gas Lift Process Analyse des performances de modèles black-oil pour le procédé d’extraction par injection de gaz

    Directory of Open Access Journals (Sweden)

    Mahmudi M.

    2013-03-01

    Full Text Available Artificial gas lift is frequently used to boost production rate of mature oil fields. An integrated mathematical model was developed in order to track the spatial and temporal changes in various components of the continuous gas lift process. The computational demand for solving the comprehensive gas lift model highly depends on the thermodynamic treatment of the hydrocarbon fluids involved. A full compositional treatment using an equation of state provides the most accurate results but at a high computational cost. The results of this article showed that the computational cost can be halved without sacrificing accuracy by using reduced parameter stability and flash calculation procedures. It was also demonstrated that a Modified Black-Oil treatment of the fluids can provide reasonable accuracy at a much-reduced computational cost. The Modified Black-Oil treatment provides a valuable tool when the model has to be solved many hundreds of times to find the optimal combination of the gas lift parameters. Les procédés artificiels d’extraction par injection de gaz sont utilisés pour améliorer le taux de récupération des champs pétroliers matures. Un modèle mathématique intégré a été développé pour détecter de faibles changements temporels et spatiaux dans plusieurs composants des procédés continus d’extraction par injection de gaz. La solution numérique utilisée pour résoudre le modèle du procédé d’extraction dépend fortement du comportement thermodynamique des hydrocarbures impliqués. Un traitement complet de la composition utilisant une équation d’état offre les résultats les plus précis, mais à un coût de calcul très élevé. Les résultats de nos travaux de recherche montrent que l’implication des paramètres de stabilité et des procédures de calcul flash, peut diviser par deux le coût du calcul tout en gardant la précision attendue. Ces travaux montrent que la précision admissible peut être

  10. Surface Spectroscopy Center Of Excellence Project

    Science.gov (United States)

    Wooden, Diane

    2014-01-01

    We propose to develop a national center of excellence in Regolith Radiative Transfer (RRT), i.e., in modeling spectral reflectivity and emissivity of grainy or structured surfaces. The focus is the regime where the structural elements of grainy surfaces have grain sizes and separations of tens of microns, comparable to the wavelengths carrying diagnostic compositional information. This regime is of fundamental interest to remote sensing of planetary and terrestrial surfaces.

  11. Basic statistics with Microsoft Excel: a review.

    Science.gov (United States)

    Divisi, Duilio; Di Leonardo, Gabriella; Zaccagna, Gino; Crisci, Roberto

    2017-06-01

    The scientific world is enriched daily with new knowledge, due to new technologies and continuous discoveries. The mathematical functions explain the statistical concepts particularly those of mean, median and mode along with those of frequency and frequency distribution associated to histograms and graphical representations, determining elaborative processes on the basis of the spreadsheet operations. The aim of the study is to highlight the mathematical basis of statistical models that regulate the operation of spreadsheets in Microsoft Excel.

  12. A Model of Secondary Hydrocarbon Migration As a Buoyancy-Driven Separate Phase Flow Un modèle de migration secondaire des hydrocarbures considéré comme un écoulement en phases séparées régi par la poussée d'Archimède

    Directory of Open Access Journals (Sweden)

    Lehner F. K.

    2006-11-01

    Full Text Available A mathematical model of secondary migration is described which permits the prediction of hydrocarbon migration and accumulation patterns in a sedimentary basin, if source rock expulsion rates and geometrical and hydraulic properties of major carrier systems are known through geological time. In this model, secondary migration is treated as buoyancy-driven, segregated flow of hydrocarbons in hydrostatic aquifers. Lateral, updip migration is conceived as a Boussinesq-type, free-surface flow, with source and sink terms representing supply from source rocks and leakage through cap rocks and faults. This permits a two-dimensional, map-view mathematical description of a three-dimensional, time-dependent secondary migration system. A nine-point finite difference approximation has been developed to minimize numerical dispersion, and upstream-weighting is used to obtain stable solutions. Example computations for simple, single carrier bed structures are presented. L'article décrit un modèle mathématique de migration secondaire prédisant la migration des hydrocarbures et leur accumulation dans un bassin sédimentaire, lorsque les taux d'expulsion des roches mères et les propriétés géométriques et hydrauliques des principaux systèmes de drainage sont connus à l'échelle du temps géologique. Dans ce modèle, la migration secondaire est traitée comme un écoulement des hydrocarbures en phase séparée, contrôlé par la poussée d'Archimède, dans des aquifères hydrostatiques. La migration latérale est considérée comme un écoulement de type Boussinesq, à surface libre, avec des termes sources et puits représentant les apports venant des roches mères et les fuites à travers les couvertures et les failles. Ceci permet une description mathématique bidimensionnelle cartographiable d'un système de migration secondaire tridimensionnel et dépendant du temps. On utilise une approximation type différences finies à neuf points pour minimiser

  13. Achieving excellence with limited resources

    International Nuclear Information System (INIS)

    Anson, L.W.; Spinney, R.W.

    1985-01-01

    The achievement of excellence in safety of nuclear power plant operation is dependent in part upon establishment of a performance-based training program. Developing such a program can be a laborious, time-consuming, and very expensive effort. Conducting job and task analyses, designing course outlines from learning objectives, developing training materials, evaluating program effectiveness and managing the training process and program through the out-years will exhaust any utility's training budget and staff. Because the achievement of excellence implies that training become in part performance-based, the question arises of how best to attain quality training yet still maintain a reasonable budget and staff workload. The answer lies not just in contracting the support necessary but making use of all available resources - training staff, contractor personnel in INPO

  14. Experimental transmission electron microscopy studies and phenomenological model of bismuth-based superconducting compounds; Etudes experimentales par microscopie electronique en transmission et modele phenomenologique des composes supraconducteurs a base de bismuth

    Energy Technology Data Exchange (ETDEWEB)

    Elboussiri, Khalid

    1991-09-26

    The main part of this thesis is devoted to an experimental study by transmission electron microscopy of the different phases of the superconducting bismuth cuprates Bi{sub 2}Sr{sub 2}Ca{sub n-1}Cu{sub n}O{sub 2n+4}. In high resolution electron microscopy, the two types of incommensurate modulation realized in these compounds have been observed. A model of structure has been proposed from which the simulated images obtained are consistent with observations. The medium resolution images correlated with the electron diffraction data have revealed existence of a multi-soliton regime with latent lock in phases of commensurate periods between 4b and 10b. At last, a description of different phases of these compounds as a result of superstructures from a disordered perovskite type structure is proposed (author) [French] Le travail presente dans cette these consiste en une etude experimentale essentiellement par microscopie electronique en transmission des differentes phases supraconductrices presentes dans les composes appartenant a la famille des cuprates de bismuth Bi{sub 2}Sr{sub 2}Ca{sub n-1}Cu{sub n}O{sub 2n+4}. Les obsevations de microscopie electronique a haute resolution ont permis de mettre en evidence les differentes modulations incommensurables realisees dans ces composes. Un modele de structure est propose et a permis d'obtenir des images simulees compatibles avec les observations. D'autre part, les observations de microscopie electronique en moyenne resolution sur ces composes, combinees avec les resultats de diffraction electronique, ont montre l'existence d'un regime multisoliton associe a des phases de Lock-in latentes de parametres compris entre 4b et 10b. Enfin, une description des differentes phases de ces composes en terme de surstructures derivees de structure perovskite desordonnee est exposee. (auteur)

  15. Microstructural characterization of EXCEL alloy

    International Nuclear Information System (INIS)

    Oroza Z E, Celiz; Saumell M, Lani; Versaci, R A; Bozzano, P B

    2012-01-01

    The microstructure of Excel alloy was studied by optical and scanning electron microscopy. X-ray diffraction was used to analyze the present phases. Characteristic peaks of α-Zr (HCP), β-Zr (BCC) and δhydride (FCC) were identified. The high relatives intensities of certain peaks suggest that samples are textured. Basal poles were dominant in radial-longitudinal planes and prismatic poles have the highest concentration in radial-tangential planes (author)

  16. Samuel P. Massie Chair of Excellence Program

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, James H. [Howard Univ., Washington, DC (United States)

    2014-12-01

    Abstract In 1994 the Department of Energy established the DOE Chair of Excellence Professorship in Environmental Disciplines Program. In 2004, the Massie Chair of Excellence Professor at Howard University transitioned from Dr. Edward Martin to Dr. James H. Johnson, Jr. At the time of his appointment Dr. Johnson served as professor of civil engineering and Dean of the College of Engineering, Architecture and Computer Sciences. Program activities under Dr. Johnson were in the following areas: • Increase the institution’s capacity to conduct scientific research and technical investigations at the cutting-edge. • Promote interactions, collaborations and partnerships between the private sector, Federal agencies, majority research institutes and other HBCUs. • Assist other HBCUs in reaching parity in engineering and related fields. • Mentor young investigators and be a role model for students.

  17. Empowering boards to become instruments of innovation and excellence

    OpenAIRE

    Coulson-Thomas, Colin

    2016-01-01

    Examines the roles of directors, boards and CEOs in relation to excellence, innovation, innovative business models, leadership and human capital and the digital economy, aspects of leadership and the new, collective and shared leadership required for creativity, innovation and entrepreneurship. Written to encourage discussion at the 2016 Dubai Global Convention and 26th World Congress for Business Excellence & Innovation.

  18. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  19. Par Pond Fish, Water, and Sediment Chemistry

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  20. Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

    Science.gov (United States)

    Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

    2015-07-02

    Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

  1. BUSINESS EXCELLENCE AS A CRUCIAL COMPONENT FOR ORGANIZATION COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Zeljko Pozega

    2014-12-01

    Full Text Available Background: Business excellence represents one of the most valuable management means of achieving competitive advantage of organizations. Modern and global market demands new organizational approaches for the long-term improvement at all organization levels. Objectives: This paper is concerned with the level of business excellence in Sibenik-Knin County and the level of knowledge about the EFQM model. Moreover, this paper is concerned with the level of knowledge of the top management concerning the business excellence and quality principles. Methods/Approach: For the purpose of this paper, the research was conducted among organizations in Sibenik-Knin County. Results: The results showed that the organizations in Sibenik-Knin County lack the initiatives for the systematic approach and implementation of business excellence model, but poses the knowledge about the basic concepts of business excellence. Conclusions: The research had showed that the organizations believe that the ISO certification is sufficient for strengthening competitive advantage and organization success.

  2. Developing versus developed companies in Business Excellence initiatives

    DEFF Research Database (Denmark)

    Haffer, Rafal; Kristensen, Kai

    2008-01-01

    The paper reports the advance of Polish companies in Business Excellence initiatives. It indicates how these activities influence their performance. EFQM Excellence Model indicators are used as the evaluation criteria for the study. The performance variable is introduced to ensure the calculation...... of correlations between EFQM model indicators and performance results. The data are next estimated as a structural equation model by partial least squares using SmartPLS software (Ringle et al., 2005). That estimation is conducted on the model of the Danish Business Excellence Index methodology (Kristensen et al...... results from the Business Excellence Model as a proxy for actual financial results in Poland. Data and results from a similar study done in Denmark are also described; thus, a comparison between developing Polish companies and developed Danish ones is included. Poland and Denmark are used as cases of...

  3. Modelos para determinação dos parâmetros da equação de van Genuchten para um Cambissolo Models for determination of parameters of van Genuchten equation for a Cambisol

    Directory of Open Access Journals (Sweden)

    Carlos R. de Mello

    2005-03-01

    Full Text Available Com este trabalho, objetiva-se a geração de modelos matemáticos para predição dos 4 parâmetros da equação de van Genuchten (tetaR, tetaS, alfa e n e para a umidade correspondente à capacidade de campo em função dos atributos areia, argila, matéria orgânica e densidade do solo, ambas de fácil e rotineira determinação em laboratório, além da profundidade. Coletaram-se 36 amostras não deformadas e deformadas nas profundidades de 0 a 30, 30 a 60 e 60 a 90 cm, em Cambissolo originado de gnaisse, determinando-se as umidades correspondentes às tensões de 2, 6 e 10 kPa em mesa de tensão e as referentes a 33, 100, 500 e 1500 kPa, em câmara de Richards. Para ajuste dos modelos, trabalhou-se com o programa SAS for Windows, com a rotina Proc Reg, e procedimento Backward, para selecionar as variáveis significativamente diferentes de zero num certo nível de probabilidade. Para avaliação dos modelos, consideraram-se o coeficiente de determinação e os erros de predição, tanto para os parâmetros estimados quanto para as umidades geradas pela equação de van Genuchten ajustada com os parâmetros estimados, para cada tensão descrita acima. Constatou-se que os erros foram consideravelmente pequenos, justificando a aplicação dos modelos.This work proposes to adjust mathematical models to predict the parameters of van Genuchten equation (thetaR, thetaS, alpha and n, besides a model to predict the soil moisture corresponding to the field capacity. The models express the equation parameters as dependent variables and sand, clay, organic matter, bulk density and depth as independent variables. All independent variables can be easily and routinely determined in laboratory. The samples were collected at 12 points in and three layers (0-30; 30-60; 60-90 cm of a Cambisol, using a Uhland sampler. The soil moisture at matric potentials of 2, 6 and 10 kPa were determined using a porous plate apparatus and those at matric potentials of 33

  4. Teaching excellence in nursing education: a caring framework.

    Science.gov (United States)

    Sawatzky, Jo-Ann V; Enns, Carol L; Ashcroft, Terri J; Davis, Penny L; Harder, B Nicole

    2009-01-01

    Nursing education plays a central role in the ability to practice effectively. It follows that an optimally educated nursing workforce begets optimal patient care. A framework for excellence in nursing education could guide the development of novice educators, establish the basis for evaluating teaching excellence, and provide the impetus for research in this area. However, a review of the social sciences and nursing literature as well as a search for existing models for teaching excellence revealed an apparent dearth of evidence specific to excellence in nursing education. Therefore, we developed the Caring Framework for Excellence in Nursing Education. This framework evolved from a review of the generic constructs that exemplify teaching excellence: excellence in teaching practice, teaching scholarship, and teaching leadership. Nursing is grounded in the ethic of caring. Hence, caring establishes the foundation for this uniquely nursing framework. Because a teaching philosophy is intimately intertwined with one's nursing philosophy and the ethic of caring, it is also fundamental to the caring framework. Ideally, this framework will contribute to excellence in nursing education and as a consequence excellence in nursing practice and optimal patient care.

  5. PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

    DEFF Research Database (Denmark)

    Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

    2016-01-01

    Overexpression of urokinase-type plasminogen activator receptors (uPAR) represents an important biomarker for aggressiveness in most common malignant diseases, including prostate cancer (PC). Accordingly, uPAR expression either assessed directly in malignant PC tissue or assessed directly in plasma...... and prognostic imaging method. In this review, we will focus on the recent development of uPAR PET and the relevance within prostate cancer imaging. Novel antibody and small-molecule radiotracers-targeting uPAR, including a series of uPAR-targeting PET ligands, based on the high affinity peptide ligand AE105......, have been synthesized and tested in vitro and in vivo in preclinical murine xenograft models and, recently, in a first-ever clinical uPAR PET study in cancer patients, including patients with PC. In this phase I study, a high and specific uptake of the tracer 64Cu-DOTA-AE105 was found in both primary...

  6. Determinación de los parámetros para la modelación del generador asincrónico; Determination of the Parameters for the Modelation of the Asynchronous Generator

    Directory of Open Access Journals (Sweden)

    Héctor Brito Socarrás

    2011-02-01

    Full Text Available En  este trabajo se realiza un  breve estudio de   los   parámetros   que intervienen   en    los modelosmatemáticos de las máquinas asincrónicas, así como la manera de su determinación experimental, loque da la posibilidad de la modelación de una máquina asincrónica  cualquiera, de la  que  no  seconozcan sus parámetros. Por último se brindan  los  valores obtenidos  experimentalmente en  ellaboratorio de las pruebas de una máquina asincrónica y los  resultados que brinda el modelo de ungenerador asincrónico autoexcitado con  dichos datos.  After a brief study of the parameters which are needed for the formulation of the most   frequently usedmathematical models for electrical induction machines, the authors give a way for their experimentaldetermination in order to establish the computer simulation of  induction machine whose parameters  arepreviously unknown. Finally are given the  values of parameters obtained at a case  study of an inductionmachine performed  in the  laboratory,  as well  as the simulation results of a  self-excited inductiongenerator using  the  above mentioned parameters.

  7. Investigating the Status of Training Quality of Ophthalmologic Residents in Khatam-Ol-Anbia Hospital in Mashhad, Based on the Standards of EFQM Organizational Excellence Model in the Academic Year 2012-2013

    Directory of Open Access Journals (Sweden)

    Akbar Derakhshan

    2016-05-01

    Full Text Available  Background and Purpose: As the leaders of educational organizations, universities use various models and approaches in evaluating their activities. However, excellence model for evaluation of educational services can demonstrate the distinction of this evaluation procedure. The aim of this study is to investigate the status of training quality of ophthalmologic residents in Khatam-Ol-Anbia Hospital in Mashhad based on the standards of organizational excellence model EFQM in the educational year of 2012-2013.Methods: This descriptive cross-sectional study has been conducted in the second half of 2013 in the educational, research, and therapeutic hospital of Khatam-Ol-Anbia, among the hospitals affiliated with Mashhad University of Medical Sciences. All students in the stage of residency in Ophthalmology entered this study. In this research, 18 men and 6 women participated. Moreover, in the statistical population of this research, 14 of the residents were non-native and 10 were native. Using standardized questionnaire of organizational excellence model in higher education sector and the degree of achievement of the educational services outcomes presented to learners was investigated. This questionnaire was first adapted from the main booklet published by Sheffield University, England. Following the extraction of the preliminary questionnaire, normalization of the instrument for validity was done by expert judgment, to examine the internal consistency of the various sections of the instrument and the reliability, Cronbach’s alpha coefficient of 0.96 was obtained. The questionnaire consists of 4 main sections, each of which questions contain certain indices of educational services. Using SPSS 16 and congruent with the background and research questions, the results were obtained.Results: The mean value of general status of the training quality of Ophthalmology residents has been obtained as 6.66 (of a max of 10. The mean value for the indices of

  8. Novo modelo de parâmetros concentrados aplicado à hidratação de grãos New model of lumped parameters applied to grain hydration

    Directory of Open Access Journals (Sweden)

    Mônica Ronobo Coutinho

    2007-09-01

    Full Text Available Este trabalho apresenta um novo modelo fenomenológico de parâmetros concentrados para a hidratação de grãos de soja, obtido a partir de um balanço de massa em regime transiente nos grãos, admitindo duas hipóteses básicas: 1º variação do volume do grão diretamente proporcional à variação da sua massa ao longo da hidratação; e 2º variação exponencial do coeficiente de transferência de massa aparente em função da concentração de água na soja. Este modelo possui apenas dois parâmetros, os quais foram estimados a partir do ajuste deste às medidas da umidade do grão ao longo do tempo, avaliadas em várias temperaturas. Os resultados revelam que o modelo proposto é adequado, enquanto o coeficiente de transferência de massa aparente depende da temperatura e apresenta variações significativas ao longo da hidratação.A new first principle model with lumped parameters was developed for the hydration of soya beans. A transient mass balance was applied to the soya beans taking into consideration two basic hypotheses:1º variation of the volume directly proportional to the variation of the mass of the grain during the process, 2º Exponential variation of the apparent coefficient of mass transfer in function of water concentration in the soy. This model has got just two parameters, which were evaluated from adjustment of model to the measures of grain moisture along the time, at several temperatures. The results indicate that the proposed model was able to represent the hydration process, while the mass transfer coefficient depends on the temperature and it presents significant variations along the hydration.

  9. Data analysis for physical scientists featuring Excel

    CERN Document Server

    Kirkup, Les

    2012-01-01

    The ability to summarise data, compare models and apply computer-based analysis tools are vital skills necessary for studying and working in the physical sciences. This textbook supports undergraduate students as they develop and enhance these skills. Introducing data analysis techniques, this textbook pays particular attention to the internationally recognised guidelines for calculating and expressing measurement uncertainty. This new edition has been revised to incorporate Excel® 2010. It also provides a practical approach to fitting models to data using non-linear least squares, a powerful technique which can be applied to many types of model. Worked examples using actual experimental data help students understand how the calculations apply to real situations. Over 200 in-text exercises and end-of-chapter problems give students the opportunity to use the techniques themselves and gain confidence in applying them. Answers to the exercises and problems are given at the end of the book.

  10. Control and diagnosis oriented modelling of the compression ignition engine; Modelisation du moteur a allumage par compression dans la perspective du controle et du diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Grondin, O

    2004-12-15

    This thesis has described an investigation into the modelling of compression ignition engine for control and diagnosis purpose. The Diesel engine is the most efficient and clean internal combustion engine due to modem electromechanical actuators. However, pollutant emission regulations are much more stricter, thus, these complex systems need sophisticated and efficient control algorithms to reach very low emission levels. For this task, engine models are required at each step of the control system development: control laws synthesis, simulation and validation. The system under study is a six cylinder direct injection Diesel engine fitted with a turbocharger. The model of this system is based on physical laws for some parts of the engine such as cylinders, manifolds, turbocharger and crank-slider system. In order to reduce computing time we choose to model heat transfer and heat release during combustion using simple empirical correlations. Resulting model has been implemented in the Matlab-Simulink environment and it can predict variables of interest for control purpose with one degree crank angle resolution. The model has been tested numerically and compared with an industrial engine simulation code with good results. Moreover, model output variables are in good agreement with experimental data recorded on a heavy-duty research engine. The engine model has been embedded on a board providing enough computing performances to perform real-time simulations, this will be helpful for 'hardware-in-the-loop' simulations. Another part of this study is dedicated to the combustion process modelling using a non linear phenomenological model: the NARMAX model. The goal is to predict the in-cylinder pressure evolution using other measurements available on the engine. The NARMAX model parameters have been identified using input-output data carried out from the experimental engine. Such model is well suited for real-time applications compare to numerically cost effective physical

  11. Control and diagnosis oriented modelling of the compression ignition engine; Modelisation du moteur a allumage par compression dans la perspective du controle et du diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Grondin, O.

    2004-12-15

    This thesis has described an investigation into the modelling of compression ignition engine for control and diagnosis purpose. The Diesel engine is the most efficient and clean internal combustion engine due to modem electromechanical actuators. However, pollutant emission regulations are much more stricter, thus, these complex systems need sophisticated and efficient control algorithms to reach very low emission levels. For this task, engine models are required at each step of the control system development: control laws synthesis, simulation and validation. The system under study is a six cylinder direct injection Diesel engine fitted with a turbocharger. The model of this system is based on physical laws for some parts of the engine such as cylinders, manifolds, turbocharger and crank-slider system. In order to reduce computing time we choose to model heat transfer and heat release during combustion using simple empirical correlations. Resulting model has been implemented in the Matlab-Simulink environment and it can predict variables of interest for control purpose with one degree crank angle resolution. The model has been tested numerically and compared with an industrial engine simulation code with good results. Moreover, model output variables are in good agreement with experimental data recorded on a heavy-duty research engine. The engine model has been embedded on a board providing enough computing performances to perform real-time simulations, this will be helpful for 'hardware-in-the-loop' simulations. Another part of this study is dedicated to the combustion process modelling using a non linear phenomenological model: the NARMAX model. The goal is to predict the in-cylinder pressure evolution using other measurements available on the engine. The NARMAX model parameters have been identified using input-output data carried out from the experimental engine. Such model is well suited for real-time applications compare to numerically cost

  12. Excellence through radiation protection practices

    International Nuclear Information System (INIS)

    Lee, D.A.; Armitage, G.; Popple, R.T.; Carrigan, J.T.

    1987-01-01

    The nuclear generation program at Ontario Hydro was initiated in the early 1960s. Over the last two decades the program has expanded to a planned capacity of ∼ 14,000 MW(electric) by 1992. Each of the nuclear stations consists of four identical reactor units and they range in size from 520 to 880 MW(electric). The overall objectives of Ontario Hydro's radiation protection program are stated as follows: (1) to prevent detrimental nonstochastic health effects to employees and the public; (2) to limit detrimental stochastic health effects occurring in employees or the public to levels as low as reasonably achievable (ALARA), social and economic factors being taken into account; and (3) to provide a level of health and safety that is as good as, or better than, comparable safe industries. Although many elements of the radiation protection program are similar to those adopted by other electrical utilities around the world, there are some unique features that have played an important part in the improvements achieved. These include: management commitment, design responsibility, radiation protection training, operations control, and work planning. The issues that need to be addressed in striving for overall excellence in radiological safety over the next decade are summarized

  13. ITMO Photonics: center of excellence

    Science.gov (United States)

    Voznesenskaya, Anna; Bougrov, Vladislav; Kozlov, Sergey; Vasilev, Vladimir

    2016-09-01

    ITMO University, the leading Russian center in photonics research and education, has the mission to train highlyqualified competitive professionals able to act in conditions of fast-changing world. This paradigm is implemented through creation of a strategic academic unit ITMO Photonics, the center of excellence concentrating organizational, scientific, educational, financial, laboratory and human resources. This Center has the following features: dissemination of breakthrough scientific results in photonics such as advanced photonic materials, ultrafast optical and quantum information, laser physics, engineering and technologies, into undergraduate and graduate educational programs through including special modules into the curricula and considerable student's research and internships; transformation of the educational process in accordance with the best international educational practices, presence in the global education market in the form of joint educational programs with leading universities, i.e. those being included in the network programs of international scientific cooperation, and international accreditation of educational programs; development of mechanisms for the commercialization of innovative products - results of scientific research; securing financial sustainability of research in the field of photonics of informationcommunication systems via funding increase and the diversification of funding sources. Along with focusing on the research promotion, the Center is involved in science popularization through such projects as career guidance for high school students; interaction between student's chapters of international optical societies; invited lectures of World-famous experts in photonics; short educational programs in optics, photonics and light engineering for international students; contests, Olympics and grants for talented young researchers; social events; interactive demonstrations.

  14. Kinetic modelling of hydrocracking catalytic reactions by the single events theory; Modelisation cinetique des reactions catalytiques d`hydrocraquage par la theorie des evenements constitutifs

    Energy Technology Data Exchange (ETDEWEB)

    Schweitzer, J.M.

    1998-11-23

    Kinetic modelling of petroleum hydrocracking is particularly difficult given the complexity of the feedstocks. There are two distinct classes of kinetics models: lumped empirical models and detailed molecular models. The productivity of lumped empirical models is generally not very accurate, and the number of kinetic parameters increases rapidly with the number of lumps. A promising new methodology is the use of kinetic modelling based on the single events theory. Due to the molecular approach, a finite and limited number of kinetic parameters can describe the kinetic behaviour of the hydrocracking of heavy feedstock. The parameters are independent of the feedstock. However, the available analytical methods are not able to identify the products on the molecular level. This can be accounted for by means of an posteriori lamping technique, which incorporates the detailed knowledge of the elementary step network. Thus, the lumped kinetic parameters are directly calculated from the fundamental kinetic coefficients and the single event model is reduced to a re-lumped molecular model. Until now, the ability of the method to extrapolate to higher carbon numbers had not been demonstrated. In addition, no study had been published for three phase (gas-liquid-solid) systems and a complex feedstock. The objective of this work is to validate the `single events` method using a paraffinic feedstock. First of all, a series of experiments was conducted on a model compound (hexadecane) in order to estimate the fundamental kinetic parameters for acyclic molecules. To validate the single event approach, these estimated kinetic coefficients were used to simulate hydrocracking of a paraffinic mixture ranging from C11 to C18. The simulation results were then compared to the results obtained from the hydrocracking experiments. The comparison allowed to validate the model for acyclic molecules and to demonstrate that the model is applicable to compounds with higher carbon numbers. (author

  15. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  16. Recherche documentaire par titrage automatique

    OpenAIRE

    Lopez , Cédric; Prince , Violaine; Roche , Mathieu

    2011-01-01

    Nous proposons dans cet article un système facilitant la recherche d'information dans un ensemble de documents textuels, basé sur le titrage (et sous-titrage) automatique. Ce dernier peut se révéler crucial, par exemple, dans le cadre de la problématique de l'accessibilité des pages web (norme W3C). Notre processus de titrage automatique consiste à extraire des syntagmes nominaux pertinents dans les textes, pouvant constituer des titres ou sous-titres candidats. Une approche originale combina...

  17. Computing broadband accelerograms using kinematic rupture modeling; Generation d'accelerogrammes synthetiques large-bande par modelisation cinematique de la rupture sismique

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Paredes, J.A

    2007-05-15

    In order to make the broadband kinematic rupture modeling more realistic with respect to dynamic modeling, physical constraints are added to the rupture parameters. To improve the slip velocity function (SVF) modeling, an evolution of the k{sup -2} source model is proposed, which consists to decompose the slip as a sum of sub-events by band of k. This model yields to SVF close to the solution proposed by Kostrov for a crack, while preserving the spectral characteristics of the radiated wave field, i.e. a w{sup 2} model with spectral amplitudes at high frequency scaled to the coefficient of directivity C{sub d}. To better control the directivity effects, a composite source description is combined with a scaling law defining the extent of the nucleation area for each sub-event. The resulting model allows to reduce the apparent coefficient of directivity to a fraction of C{sub d}, as well as to reproduce the standard deviation of the new empirical attenuation relationships proposed for Japan. To make source models more realistic, a variable rupture velocity in agreement with the physics of the rupture must be considered. The followed approach that is based on an analytical relation between the fracture energy, the slip and the rupture velocity, leads to higher values of the peak ground acceleration in the vicinity of the fault. Finally, to better account for the interaction of the wave field with the geological medium, a semi-empirical methodology is developed combining a composite source model with empirical Green functions, and is applied to the Yamaguchi, M{sub w} 5.9 earthquake. The modeled synthetics reproduce satisfactorily well the observed main characteristics of ground motions. (author)

  18. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  19. Excel for chemists: a comprehensive guide

    National Research Council Canada - National Science Library

    Billo, E. Joseph

    2011-01-01

    ..., biological, and medicinal calculations. Including a CD-ROM for Windows, this new edition provides chemists and students with the a detailed guide to using the current versions of Excel (Excel 2007 and 2010...

  20. Realisatie van Excel Kwadraat in de praktijk

    NARCIS (Netherlands)

    Dijkstra, Elma

    2013-01-01

    Dijkstra, E. M. (2013, 2 July). Realisatie van Excel Kwadraat in de praktijk [Realization of Excellent Education in practice]. Presentation held at the OLK-meeting, ITS, Radboud University, Nijmegen, The Netherlands.

  1. Business excellence journey in countries in transition

    Directory of Open Access Journals (Sweden)

    Pavel Castka

    2001-01-01

    Full Text Available This paper describes the journey toward business excellence regarding the influence of the contemporary global environment, as well as the specifics of the environment in countries in transition (the environment in the Czech Republic is taken as a representative model. Closer focus is given on problems connected with productivity, effectivity, innovation, quality and certification, use of IT/IS and on problems with participation of employees. The abovementioned characteristics make up the goals of a change to a process-oriented company. In regard of business downturn in many companies in the post-communist environment, these goals are achievable by radical change using the ideas of Business Process Reengineering (BPR and the process-oriented model described at the end of this paper.

  2. IDRANAP - European Centre of Excellence

    International Nuclear Information System (INIS)

    Buzatu, Florin D.

    2003-01-01

    Selected by the European Commission (EC) experts out of 185 proposals from 11 countries, IDRANAP (Inter-Disciplinary Research and Applications based on Nuclear and Atomic Physics) is the only EC Centre of Excellence in nuclear physics. The project, initiated and developed by a remarkable team from our institute, researchers with a recognized international scientific level, has as main objectives: - promotion in Romania and in the region of modern applications derived from basic and applied research in nuclear and atomic physics; - disciplinary research in ecology, health, biology, science of materials; - specific nuclear and atomic physics research aimed to open new possibilities for applications; - to ensure stimulative conditions for PhD students from Romania and other EC candidate countries to improve their knowledge and experience by joining scientific activities in the region, a fact that might counteract their tendency to migrate to Western countries. The high scientific level of researchers, their access to national and international facilities as well as the link with prestigious laboratories abroad and the socio-economic demand motivated the development of the project. Among expected results, we mention: improving and spreading the scientific knowledge by publications; producing new facilities, devices and instruments; application of nuclear methods in industry, health-care and environment protection, and training of young researchers. The project consists of 18 workpackages structured in 5 distinct areas: - Determining environmental pollution; - Nuclear methods in biology and medicine; - Radionuclide metrology; - Analysis and characterization of materials; - Nuclei far from stability, decay modes, cosmic rays, and facilities.We make an up-to-date presentation of obtained results and activities performed within IDRANAP project, as well as a short overview of our institute. (author)

  3. BENCHMARKING WORKSHOPS AS A TOOL TO RAISE BUSINESS EXCELLENCE

    Directory of Open Access Journals (Sweden)

    Milos Jelic

    2011-03-01

    Full Text Available Annual competition for national award for business excellence appears to be a good opportunity for participating organizations to demonstrate their practices particularly those ones which enable them to excel. National quality award competition in Serbia (and Montenegro, namely "OSKAR KVALITETA" started in 1995 but was limited to competition cycle only. However, upon establishing Fund for Quality Culture and Excellence - FQCE in 2002, which took over OSKAR KVALITETA model, several changes took place. OSKAR KVALITETA turned to be annual competition in business excellence, but at the same time FQCE started to offer much wider portfolio of its services including levels of excellence programs, assessment and self-assessment training courses and benchmarking workshops. These benchmarking events have hosted by Award winners or other laureates in OSKAR KVALITETA competition who demonstrated excellence in regard of some particular criteria thus being in position to share their practice with other organizations. For six years experience in organizing benchmarking workshops FQCE scored 31 workshops covering major part of model issues. Increasing level of participation on the workshops and distinct positive trends of participants expressed satisfaction may serve as a reliable indicator that the workshops have been effective in actuating people to think and move in business excellence direction.

  4. A Comprehensive Model of the Dry Desulphurisation Process Une modélisation non empirique du procédé de désulfuration par voie sèche

    Directory of Open Access Journals (Sweden)

    Flament P.

    2006-11-01

    Full Text Available Due to the high investment cost of the wet scrubbing, the dry desulphurisation process remains an attractive way to remove sulphur dioxide when reduction level should not be higher than 90%. In this technique, the SO2 is removed from flue gases by direct injection of small calcium based sorbents such as calcium carbonate (CaCO3 or calcium hydroxide (Ca(OH² . The sorbent is first transformed into calcium oxide (CaO before reacting with SO2 to form a stable calcium sulphate (CaSO4. Although the global reactions are rather simple, a full description of the mechanism requires the knowledge of both, the initial physical properties of the sorbent and the evolution of these properties during the reaction. Furthermore, the way how particles are injected and dispersed into the SO2 containing gases is also a major issue of the dry desulphurisation process. Both aspects are considered in this paper since a specialised routine was build to describe the calcination-sulphation process and coupled with the KIVA code to perform 3D calculations under real industrial conditions. The desulphurisation model was first tested alone using the kinetic data of the International Flame Research Foundation and then, coupled with KIVA to simulate the desulphurisation process in a new type of boiler which is developed by BABCOCK Entreprise and the Institut Français du Pétrole (the AUDE boiler. In this last case, the objective was to determine the sorbent injection locations leading to the highest desulphurisation efficiencies. As the dispersion of particles is an important parameter of the desulphurisation process, an example of validation of the KIVA dispersion model is also presented in this paper. For the selected test case, i. e: particle dispersion in a plane mixing layer, a good agreement was found between the experimental results of Ando et al (1990 and the calculations performed with KIVA. Par suite du coût d'investissement très élevé du procédé de lavage

  5. Teaching Excellence Initiatives: Modalities and Operational Factors

    Science.gov (United States)

    Land, Ray; Gordon, George

    2015-01-01

    Teaching excellence is at the centre of national and international higher education policy. The Higher Education Academy (HEA) is a part of the debate to develop a shared understanding of what constitutes teaching excellence and has published research including "Considering Teaching Excellence in Higher Education: 2007-2013" by Dr Vicky…

  6. Etude d'un modele de Boltzmann sur reseau pour la simulation assistee par ordinateur des fluides a plusieurs phases immiscibles

    Science.gov (United States)

    Leclaire, Sebastien

    The computer assisted simulation of the dynamics of fluid flow has been a highly rewarding topic of research for several decades now, in terms of the number of scientific problems that have been solved as a result, both in the academic world and in industry. In the fluid dynamics field, simulating multiphase immiscible fluid flow remains a challenge, because of the complexity of the interactions at the flow phase interfaces. Various numerical methods are available to study these phenomena, and, the lattice Boltzmann method has been shown in recent years to be well adapted to solving this type of complex flow. In this thesis, a lattice Boltzmann model for the simulation of two-phase immiscible flows is studied. The main objective of the thesis is to develop this promising method further, with a view to enhancing its validity. To achieve this objective, the research is divided into five distinct themes. The first two focus on correcting some of the deficiencies of the original model. The third generalizes the model to support the simulation of N-phase immiscible fluid flows. The fourth is aimed at modifying the model itself, to enable the simulation of immiscible fluid flows in which the density of the phases varies. With the lattice Boltzmann class of models studied here, this density variation has been inadequately modeled, and, after 20 years, the issue still has not been resolved. The fifth, which complements this thesis, is connected with the lattice Boltzmann method, in that it generalizes the theory of 2D and 3D isotropic gradients for a high order of spatial precision. These themes have each been the subject of a scientific article, as listed in the appendix to this thesis, and together they constitute a synthesis that explains the links between the articles, as well as their scientific contributions, and satisfy the main objective of this research. Globally, a number of qualitative and quantitative test cases based on the theory of multiphase fluid flows

  7. SECHAGE DE PRODUITS GRANULAIRES PAR DESHYDRATATION PAR DETENTES SUCCESSIVES (DDS)

    OpenAIRE

    Abdulla , Galal; Mellouk , Hamid; Belghit , Abdelhamid; Allaf , Karim

    2009-01-01

    International audience; Dans cette étude, nous avons évalué les performances d'un nouveau procédé de séchage dans le cas du liège en granulés. Ce procédé (La déshydratation par détentes successives : DDS) consiste à soumettre le matériau liège dans une chambre hermétique aux variations cycliques de la pression. Chaque cycle est composé d'une compression et d'une décompression. La phase de compression est réalisée en injectant de l'air comprimé à température ambiante provenant d'un compresseur...

  8. Report of the seminar modeling of pollutants emissions by road transport; Compte-rendu du seminaire modelisation des emissions de polluants par le transport routier

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This seminar was organised by A.D.E.M.E. around the following themes: uncertainties and sensitivity analysis of the C.O.P.E.R.T. 3 model (computer programme to calculate emissions from road transport), presentation of studies using the C.O.P.E.R.T. 3 model for the estimation of road transport emissions, the future of the modeling of transport emissions from C.O.P.E.R.T.3 to A.R.T.E.M.I.S. (assessment and reliability of transport emission models and inventory systems). The interventions were as follow: uncertainties and sensitivity analysis of the C.O.P.E.R.T. 3 model, emissions from road transport in the E.S.C.O.M.P.T.E. programme (study of sensitivity), analysis of sensitivity at the level of temporal aggregation of the spatialized traffic (to evaluate the sensitivity of an inventory at the level of temporal aggregation of traffic data on an important geographic area) application in the case of the I.N.T.E.R.R.E.G. project (Alsace), the road transport part of the regional plan for air quality in Bourgogne taking into account the road network, intercomparison of tools and inventory methods of road transport emissions, evolution of the French automobile park until 2005 and new projections, application of C.O.P.E.R.T. 3 to the French context a new version of I.M.P.A.C.T.- A.D.E.M.E., the European project A.R.T.E.M.I.S. structures novelties considered for the road transport emissions modeling. (N.C.)

  9. Modélisation qualitative des agro-écosystèmes et aide à leur gestion par utilisation d’outils de model-checking

    OpenAIRE

    Zhao , Yulong

    2014-01-01

    The modeling in the domain of agro-ecology is important since it helps us to better understand the interactiosn between the environment and the human activities. Some research works based on simulation has been carried out during the recent years. Mainwhile, not only these simulation tools are difficult to use by the non expert users, but also the high complexity of models makes interactive uses impossible. We propose an approch in which we represent the system to be studied in a discret even...

  10. Model of the containment building of Almaraz NPP and the system of recombiners PARs, with the GOTHIC code, for the study of the diffusion of combustible gases

    International Nuclear Information System (INIS)

    Garcia Gonzalez, M.; Huelamo, E.; Mazrtinez, M.; Perez, J. R.

    2014-01-01

    This paper presents the analysis of distribution of gases within the containment building carried out a simulation model with the code Thermo hydraulic GOTHIC, which has been evaluated based on passive autocatalytic recombiners gas control system. The model considers scenarios of severe accident with specific conditions that produce the most hydrogen generation rates. Intended to verify the effectiveness of the control system of gas expected to be installed in the Almaraz Nuclear power plant so that the number and location of recombiners equipment meets its function of preventing the formation of explosive atmospheres which impairs the integrity of the containment, reducing and limiting the concentration of combustible gases during the postulated accident. (Author)

  11. Kinetic modelling of hydro-treatment reactions by study of different chemical groups; Modelisation cinetique des reactions d`hydrotraitement par regroupement en familles chimiques

    Energy Technology Data Exchange (ETDEWEB)

    Bonnardot, J

    1998-11-19

    Hydro-treatment of petroleum shortcuts permits elimination of unwanted components in order to increase combustion in engine and to decrease atmospheric pollution. Hydro-desulfurization (HDS), Hydro-denitrogenation (HDN) and Hydrogenation of aromatics (HDA) of a LCO (Light Cycle Oil)-Type gas oil have been studied using a new pilot at a fixed temperature with a NiMo/Al{sub 2}O{sub 3} catalyst. A hydrodynamic study showed that reactions occurring in the up-flow fixed bed reactor that has been used during the experiments, were governed exclusively by chemical reaction rates and not by diffusion. Through detailed chemical analysis, height chemical groups have been considered: three aromatics groups, one sulfided group, one nitrogenized and NH{sub 3}, H{sub 2}S, H{sub 2}. Two Langmuir-Hinshelwood-type kinetic models with either one or two types of sites have been established. The model with two types of site - one site of hydrogenation and one site of hydrogenolysis - showed a better fit in the modeling of the experimental results. This model enables to forecast the influence of partial pressure of H{sub 2}S and partial pressure of H{sub 2} on hydro-treatment reactions of a LCO-type gas oil. (author) 119 refs.

  12. Experimental study and modelling of iron ore reduction by hydrogen; Etude experimentale et modelisation de la reduction du minerai de fer par l'hydrogene

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, D

    2008-01-15

    In an effort to find new ways to drastically reduce the CO{sub 2} emissions from the steel industry (ULCOS project), the reduction of iron ore by pure hydrogen in a shaft furnace was investigated. The work consisted of literature, experimental, and modelling studies. The chemical reaction and its kinetics were analysed on the basis of thermogravimetric experiments and physicochemical characterizations of partially reduced samples. A specific kinetic model was designed, which simulates the successive reactions, the different steps of mass transport, and possible iron sintering, at the particle scale. Finally, a 2-dimensional numerical model of a shaft furnace was developed. It depicts the variation of the solid and gas temperatures and compositions throughout the reactor. One original feature of the model is using the law of additive characteristic times for calculating the reaction rates. This allowed us to handle both the particle and the reactor scale, while keeping reasonable calculation time. From the simulation results, the influence of the process parameters was assessed. Optimal operating conditions were concluded, which reveal the efficiency of the hydrogen process. (author)

  13. Simulating groundwater-surface water interactions in the Canadian Prairies using a coupled land-atmosphere model (ParFlow-CLM)

    Science.gov (United States)

    Ali, M. A.; Ireson, A. M.; Keim, D.

    2015-12-01

    The Canadian prairies are cold and dry. Surface depressions are ubiquitous, and contain permanent or ephemeral ponds. The ponds are filled by snowmelt and precipitation on the ponds and lose a significant portion of their water to evaporation, but also, depending on their landscape position, may spill to other ponds or channels, recharge groundwater, or received groundwater discharge. Since precipitation and actual evaporation are closely balanced, the pond water balances are very sensitive to change in climate, and the prairies in general have been subject to damaging floods and droughts, in particular in the last decade or two. A 2.25 km2 field site at St Denis, central Saskatchewan, contains over 100 ponds, some permanent, some ephemeral, some saline, some fresh, some recharging groundwater, some receiving groundwater discharge. The site has been extensively studied for almost 50 years, with about one decade of continuous meteorological data, and three years of detailed pond level, soil moisture and temperature, and groundwater data. The objective of this study was to assess the performance of PARFLOW-CLM (a coupled land-atmosphere model) in simulating the pond-groundwater interactions at this site. Our conceptual model of the site includes soil properties that are progressively weathered with depth, and we implement this in a simplified dual permeability mathematical model of the soil hydraulic properties, whereby storage is dominated by the matrix and flow is dominated by macropores. The model performance was surprisingly good, doing quite a good job of capturing the observed groundwater and pond level dynamics. The soil freezing regime is also captured reasonably well, though the timing and pattern of the zero degree isotherm during soil thaw, which is critically important for runoff generation processes, was not captured as well. The model provides credible insights into the spatial patterns of evapotranspiration, and the seasonal dynamics of subsurface

  14. One-Dimensional Modelling of Polymer Flood Performance. Analytical and Graphical Solutions Modélisation de l'efficacité du déplacement unidimensionnel par injection de polymères. Solutions analytiques et graphiques

    Directory of Open Access Journals (Sweden)

    Grattoni C. A.

    2006-11-01

    Full Text Available A graphical method for simulating linear polymer flooding is proposed. The method is based upon the analytical solution of Darcy's law and continuity equation which describe the two-phase, one-dimensional, incompressible flow of oil and polymer solution through the reservoir rock. Continuous polymer injection and polymer slug injection are considered. Several physical mechanisms determining microscopic displacement efficiency are taken into account: resistance factor, residual resistance factor, retention composed by adsorption and mechanical entrapment, and inaccessible pore volume. Other properties are not considered: mixing and dispersion, shear and thermal degradation. This analytical-graphical model closely reproduces linear laboratory oil displacement experiments. Consequently, it can be used by the Field Engineer to rapidly estimate the additional oil recoverable by a linear polymer flood. On propose dans cet article une méthode graphique de simulation de l'injection de polymères dans le cas unidimensionnel. Cette méthode est basée sur la solution analytique de la loi de Darcy et de l'équation de continuité qui décrivent l'écoulement diphasique incompressible unidimen-sionnel d'huile et d'une solution de polymères à travers la roche réservoir. On examine l'injection continue et l'injection de bouchons de polymères. On prend en compte plusieurs mécanismes physiques qui déterminent l'efficacité du déplacement microscopique : facteur de ré-sistance, facteur de résistance résiduel, rétention due à l'adsorption et au piégeage mécanique et, enfin, volume des pores inacessibles. On ne tient pas compte des autres propriétés : mélange et dispersion, dégradation mécanique et thermique. Ce modèle analytique et graphique reproduit très directement les expériences de laboratoire de déplacement d'huile en milieu unidimensionnel. II peut donc être utilisé par l'ingénieur de chantier pour une estimation rapide de l

  15. Finite-elements modeling of radiant heat transfers between mobile surfaces; Modelisation par elements finis de transferts radiatifs entre surfaces mobiles

    Energy Technology Data Exchange (ETDEWEB)

    Daurelle, J V; Cadene, V; Occelli, R [Universite de Provence, 13 - Marseille (France)

    1997-12-31

    In the numerical modeling of thermal industrial problems, radiant heat transfers remain difficult to take into account and require important computer memory and long computing time. These difficulties are enhanced when radiant heat transfers are coupled with finite-elements diffusive heat transfers because finite-elements architecture is complex and requires a lot of memory. In the case of radiant heat transfers along mobile boundaries, the methods must be optimized. The model described in this paper concerns the radiant heat transfers between diffuse grey surfaces. These transfers are coupled with conduction transfers in the limits of the diffusive opaque domain. 2-D and 3-D geometries are analyzed and two configurations of mobile boundaries are considered. In the first configuration, the boundary follows the deformation of the mesh, while in the second, the boundary moves along the fixed mesh. Matter displacement is taken into account in the term of transport of the energy equation, and an appropriate variation of the thermophysical properties of the transition elements between the opaque and transparent media is used. After a description of the introduction of radiative limit conditions in a finite-elements thermal model, the original methods used to optimize calculation time are explained. Two examples of application illustrate the approach used. The first concerns the modeling of radiant heat transfers between fuel rods during a reactor cooling accident, and the second concerns the study of heat transfers inside the air-gap of an electric motor. The method of identification of the mobile surface on the fixed mesh is described. (J.S.) 12 refs.

  16. Finite-elements modeling of radiant heat transfers between mobile surfaces; Modelisation par elements finis de transferts radiatifs entre surfaces mobiles

    Energy Technology Data Exchange (ETDEWEB)

    Daurelle, J.V.; Cadene, V.; Occelli, R. [Universite de Provence, 13 - Marseille (France)

    1996-12-31

    In the numerical modeling of thermal industrial problems, radiant heat transfers remain difficult to take into account and require important computer memory and long computing time. These difficulties are enhanced when radiant heat transfers are coupled with finite-elements diffusive heat transfers because finite-elements architecture is complex and requires a lot of memory. In the case of radiant heat transfers along mobile boundaries, the methods must be optimized. The model described in this paper concerns the radiant heat transfers between diffuse grey surfaces. These transfers are coupled with conduction transfers in the limits of the diffusive opaque domain. 2-D and 3-D geometries are analyzed and two configurations of mobile boundaries are considered. In the first configuration, the boundary follows the deformation of the mesh, while in the second, the boundary moves along the fixed mesh. Matter displacement is taken into account in the term of transport of the energy equation, and an appropriate variation of the thermophysical properties of the transition elements between the opaque and transparent media is used. After a description of the introduction of radiative limit conditions in a finite-elements thermal model, the original methods used to optimize calculation time are explained. Two examples of application illustrate the approach used. The first concerns the modeling of radiant heat transfers between fuel rods during a reactor cooling accident, and the second concerns the study of heat transfers inside the air-gap of an electric motor. The method of identification of the mobile surface on the fixed mesh is described. (J.S.) 12 refs.

  17. La preuve par le nombre

    Directory of Open Access Journals (Sweden)

    Hélène Verdier

    2012-04-01

    Full Text Available S’il en était besoin, la question des usages et de la finalité des résultats de l’inventaire général pourrait être abordée par le nombre : nombre d’œuvres répertoriées, de communes inventoriées, de clichés photographiques réalisés, de dossiers, de consultations des notices dans les bases de données… Les additions aujourd’hui sont éloquentes, mais elles laissent dans l’ombre le rôle de l’inventaire qui, en mettant en œuvre une démarche systématique de connaissance, participe à l’ identificatio...

  18. Preselecting Well Test Interpretation Models Using External Data Présélection de modèles d'interprétation de tests de puits par l'utilisation de données externes

    Directory of Open Access Journals (Sweden)

    Harrison I.

    2006-11-01

    Full Text Available The first stage in interpreting a well test is concerned with identifying a well test interpretation (WTI model for the reservoir that is consistent with all the known data and whose theoretical output response is qualitatively similar to the actual well test response. Conventionally, engineers identify WTI models by using WTI software to plot functions of well test pressure against time and then diagnose components of WTI models from their characteristic curve signatures, together with evidence from external (geological and engineering data. This paper focuses on the use of external data for preselecting WTI models, which can then be verified using conventional well test analysis techniques. The KADS methodology for developing knowledge based systems (KBS was adopted and the inference layer structure for the WTI model preselection task was derived. The WTI model preselection task will form one part of a KBS for well test interpretation, SPIRIT, being developed jointly by Artificial Intelligence Applications Institute and Heriot-Watt University. La première étape dans l'interprétation d'un test de puits est celle de l'identification d'un modèle d'interprétation (WTI pour le réservoir, qui soit en accord avec l'ensemble des données connues, et dont la sortie théorique est qualitativement semblable à celle du puits testé. Pour ceci, les ingénieurs de réservoir utilisent habituellement des logiciels WTI qui calculent et tracent la pression de test de puits en fonction du temps. Cela leur permet de diagnostiquer les composantes des modèles WTI à partir de leurs signatures caractéristiques, le diagnostic étant complété par la prise en compte d'informations externes, de géologie ou d'ingénierie. Cet article est consacré à l'utilisation de données externes pour la préselection des modèles WTI, modèles qui peuvent être ensuite validés au moyen de techniques classiques d'analyse de tests de puits. La méthodologie de d

  19. Thermo-mechanical behaviour modelling of particle fuels using a multi-scale approach; Modelisation du comportement thermomecanique des combustibles a particules par une approche multi-echelle

    Energy Technology Data Exchange (ETDEWEB)

    Blanc, V.

    2009-12-15

    Particle fuels are made of a few thousand spheres, one millimeter diameter large, compound of uranium oxide coated by confinement layers which are embedded in a graphite matrix to form the fuel element. The aim of this study is to develop a new simulation tool for thermo-mechanical behaviour of those fuels under radiations which is able to predict finely local loadings on the particles. We choose to use the square finite element method, in which two different discretization scales are used: a macroscopic homogeneous structure whose properties in each integration point are computed on a second heterogeneous microstructure, the Representative Volume Element (RVE). First part of this works is concerned by the definition of this RVE. A morphological indicator based in the minimal distance between spheres centers permit to select random sets of microstructures. The elastic macroscopic response of RVE, computed by finite element has been compared to an analytical model. Thermal and mechanical representativeness indicators of local loadings has been built from the particle failure modes. A statistical study of those criteria on a hundred of RVE showed the significance of choose a representative microstructure. In this perspective, a empirical model binding morphological indicator to mechanical indicator has been developed. Second part of the work deals with the two transition scale method which are based on the periodic homogenization. Considering a linear thermal problem with heat source in permanent condition, one showed that the heterogeneity of the heat source involve to use a second order method to localized finely the thermal field. The mechanical non-linear problem has been treats by using the iterative Cast3M algorithm, substituting to integration of the behavior law a finite element computation on the RVE. This algorithm has been validated, and coupled with thermal resolution in order to compute a radiation loading. A computation on a complete fuel element

  20. Pension fund excellence creating value for stakeholders

    CERN Document Server

    Ambachtsheer, Keith P.

    1998-01-01

    Internationally recognized experts in the field introduce their "business excellence paradigm". In this book, two leading pension fund experts lay out a comprehensive plan for effective fund management. With the help of domestic and global case studies they critically assess current approaches to pension fund management and isolate what works and what doesn't using their unique critically acclaimed "run-it-like-a-business" model. Keith P. Ambachtsheer (Toronto, Canada) is principle at KPA Advisory Service, Inc., a pension fund management consulting firm. He runs The Ambachtsheer Letter and cofounded Cost Effective Measurement, Inc., which monitors the performance of 300 of the world's largest asset funds. D. Don Ezra (Toronto, Canada) is Director of European Consulting at Frank Russell Co. His previous books include The Struggle for Pension Fund Wealth.

  1. Modelling of nuclear glasses by classical and ab initio molecular dynamics; Modelisation de verres intervenant dans le conditionnement des dechets radioactifs par dynamiques moleculaires classique et ab initio

    Energy Technology Data Exchange (ETDEWEB)

    Ganster, P

    2004-10-15

    A calcium aluminosilicate glass of molar composition 67 % SiO{sub 2} - 12 % Al{sub 2}O{sub 3} - 21 % CaO was modelled by classical and ab initio molecular dynamics. The size effect study in classical MD shows that the systems of 100 atoms are more ordered than the larger ones. These effects are mainly due to the 3-body terms in the empirical potentials. Nevertheless, these effects are small and the structures generated are in agreement with experimental data. In such kind of glass, we denote an aluminium avoidance and an excess of non bridging oxygens which can be compensated by tri coordinated oxygens. When the dynamics of systems of 100 and 200 atoms is followed by ab initio MD, some local arrangements occurs (bond length, angular distributions). Thus, more realistic vibrational properties are obtained in ab initio MD. The modelling of thin films shows that aluminium atoms extend to the most external part of the surface and they are all tri-coordinated. Calcium atoms are set in the sub layer part of the surface and they produce a depolymerization of the network. In classical MD, tri-coordinated aluminium atoms produce an important electric field above the surface. With non bridging oxygens, they constitute attractive sites for single water molecules. (author)

  2. Impacts modeling using the SPH particulate method. Case study; Modelisation d'impacts par la methode particulaire SPH. Etude de cas

    Energy Technology Data Exchange (ETDEWEB)

    Debord, R

    1999-07-01

    The aim of this study is the modeling of the impact of melted metal on the reactor vessel head in the case of a core-meltdown accident. Modeling using the classical finite-element method alone is not sufficient but requires a coupling with particulate methods in order to take into account the behaviour of the corium. After a general introduction about particulate methods, the Nabor and SPH (smoothed particle hydrodynamics) methods are described. Then, the theoretical and numerical reliability of the SPH method is determined using simple cases. In particular, the number of neighbours significantly influences the preciseness of calculations. Also, the mesh of the structure must be adapted to the mesh of the fluid in order to reduce the edge effects. Finally, this study has shown that the values of artificial velocity coefficients used in the simulation of the BERDA test performed by the FZK Karlsruhe (Germany) are not correct. The domain of use of these coefficients was precised during a low speed impact. (J.S.)

  3. Material characterization and non destructive testing by ultrasounds; modelling, simulation and experimental validation; Caracterisation des materiaux et controle non destructif par ultrasons; modelisation, simulation et validation experimentale

    Energy Technology Data Exchange (ETDEWEB)

    Noroy-Nadal, M H

    2002-06-15

    This memory presents the research concerning the characterization of materials and the Non Destructive Testing (N.D.T) by ultrasonics. The different topics include three steps: modeling, computations and experimental validation. The studied materials concern mainly metals. The memory is divided in four parts. The first one concerns the characterization of materials versus temperature. The determination of the shear modulus G(T) is especially studied for a large temperature range, and around the melting point. The second part is devoted to studies by photothermal devices essentially focused on the modeling of the mechanical displacement and the stress field in coated materials. In this particular field of interest, applications concern either the mechanical characterization of the coating, the defect detection in the structure and finally the evaluation of the coating adhesion. The third section is dedicated to microstructural characterization using acoustic microscopy. The evaluation of crystallographic texture is especially approached, for metallic objects obtained by forming. Before concluding and pointing out some perspectives to this work, the last section concerns the introduction of optimization techniques, applied to the material characterization by acoustic microscopy. (author)

  4. Impacts modeling using the SPH particulate method. Case study; Modelisation d'impacts par la methode particulaire SPH. Etude de cas

    Energy Technology Data Exchange (ETDEWEB)

    Debord, R

    1999-07-01

    The aim of this study is the modeling of the impact of melted metal on the reactor vessel head in the case of a core-meltdown accident. Modeling using the classical finite-element method alone is not sufficient but requires a coupling with particulate methods in order to take into account the behaviour of the corium. After a general introduction about particulate methods, the Nabor and SPH (smoothed particle hydrodynamics) methods are described. Then, the theoretical and numerical reliability of the SPH method is determined using simple cases. In particular, the number of neighbours significantly influences the preciseness of calculations. Also, the mesh of the structure must be adapted to the mesh of the fluid in order to reduce the edge effects. Finally, this study has shown that the values of artificial velocity coefficients used in the simulation of the BERDA test performed by the FZK Karlsruhe (Germany) are not correct. The domain of use of these coefficients was precised during a low speed impact. (J.S.)

  5. Artificial neural network modeling and cluster analysis for organic facies and burial history estimation using well log data: A case study of the South Pars Gas Field, Persian Gulf, Iran

    Science.gov (United States)

    Alizadeh, Bahram; Najjari, Saeid; Kadkhodaie-Ilkhchi, Ali

    2012-08-01

    Intelligent and statistical techniques were used to extract the hidden organic facies from well log responses in the Giant South Pars Gas Field, Persian Gulf, Iran. Kazhdomi Formation of Mid-Cretaceous and Kangan-Dalan Formations of Permo-Triassic Data were used for this purpose. Initially GR, SGR, CGR, THOR, POTA, NPHI and DT logs were applied to model the relationship between wireline logs and Total Organic Carbon (TOC) content using Artificial Neural Networks (ANN). The correlation coefficient (R2) between the measured and ANN predicted TOC equals to 89%. The performance of the model is measured by the Mean Squared Error function, which does not exceed 0.0073. Using Cluster Analysis technique and creating a binary hierarchical cluster tree the constructed TOC column of each formation was clustered into 5 organic facies according to their geochemical similarity. Later a second model with the accuracy of 84% was created by ANN to determine the specified clusters (facies) directly from well logs for quick cluster recognition in other wells of the studied field. Each created facies was correlated to its appropriate burial history curve. Hence each and every facies of a formation could be scrutinized separately and directly from its well logs, demonstrating the time and depth of oil or gas generation. Therefore potential production zone of Kazhdomi probable source rock and Kangan- Dalan reservoir formation could be identified while well logging operations (especially in LWD cases) were in progress. This could reduce uncertainty and save plenty of time and cost for oil industries and aid in the successful implementation of exploration and exploitation plans.

  6. Viral Innovation, Sustainability, and Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Eskildsen, Jacob Kjær

    Enterprises strive to be economically sustainable. In doing so, they either contribute to or detract from environmental and social sustainability. Sustainability is hence multi-dimensional with formulations that include the familiar triple-bottom-line and BEST models. Any assessment regimen for t...

  7. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-01-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  8. Aqueous corrosion of borosilicate glasses: experiments, modeling and Monte-Carlo simulations; Alteration par l'eau des verres borosilicates: experiences, modelisation et simulations Monte-Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Ledieu, A

    2004-10-01

    This work is concerned with the corrosion of borosilicate glasses with variable oxide contents. The originality of this study is the complementary use of experiments and numerical simulations. This study is expected to contribute to a better understanding of the corrosion of nuclear waste confinement glasses. First, the corrosion of glasses containing only silicon, boron and sodium oxides has been studied. The kinetics of leaching show that the rate of leaching and the final degree of corrosion sharply depend on the boron content through a percolation mechanism. For some glass contents and some conditions of leaching, the layer which appears at the glass surface stops the release of soluble species (boron and sodium). This altered layer (also called the gel layer) has been characterized with nuclear magnetic resonance (NMR) and small angle X-ray scattering (SAXS) techniques. Second, additional elements have been included in the glass composition. It appears that calcium, zirconium or aluminum oxides strongly modify the final degree of corrosion so that the percolation properties of the boron sub-network is no more a sufficient explanation to account for the behavior of these glasses. Meanwhile, we have developed a theoretical model, based on the dissolution and the reprecipitation of the silicon. Kinetic Monte Carlo simulations have been used in order to test several concepts such as the boron percolation, the local reactivity of weakly soluble elements and the restructuring of the gel layer. This model has been fully validated by comparison with the results on the three oxide glasses. Then, it has been used as a comprehensive tool to investigate the paradoxical behavior of the aluminum and zirconium glasses: although these elements slow down the corrosion kinetics, they lead to a deeper final degree of corrosion. The main contribution of this work is that the final degree of corrosion of borosilicate glasses results from the competition of two opposite mechanisms

  9. Water leaching of borosilicate glasses: experiments, modeling and Monte Carlo simulations; Alteration par l'eau des verres borosilicates: experiences, modelisation et simulations Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Ledieu, A

    2004-10-15

    This work is concerned with the corrosion of borosilicate glasses with variable oxide contents. The originality of this study is the complementary use of experiments and numerical simulations. This study is expected to contribute to a better understanding of the corrosion of nuclear waste confinement glasses. First, the corrosion of glasses containing only silicon, boron and sodium oxides has been studied. The kinetics of leaching show that the rate of leaching and the final degree of corrosion sharply depend on the boron content through a percolation mechanism. For some glass contents and some conditions of leaching, the layer which appears at the glass surface stops the release of soluble species (boron and sodium). This altered layer (also called the gel layer) has been characterized with nuclear magnetic resonance (NMR) and small angle X-ray scattering (SAXS) techniques. Second, additional elements have been included in the glass composition. It appears that calcium, zirconium or aluminum oxides strongly modify the final degree of corrosion so that the percolation properties of the boron sub-network is no more a sufficient explanation to account for the behavior of these glasses. Meanwhile, we have developed a theoretical model, based on the dissolution and the reprecipitation of the silicon. Kinetic Monte Carlo simulations have been used in order to test several concepts such as the boron percolation, the local reactivity of weakly soluble elements and the restructuring of the gel layer. This model has been fully validated by comparison with the results on the three oxide glasses. Then, it has been used as a comprehensive tool to investigate the paradoxical behavior of the aluminum and zirconium glasses: although these elements slow down the corrosion kinetics, they lead to a deeper final degree of corrosion. The main contribution of this work is that the final degree of corrosion of borosilicate glasses results from the competition of two opposite mechanisms

  10. Water leaching of borosilicate glasses: experiments, modeling and Monte Carlo simulations; Alteration par l'eau des verres borosilicates: experiences, modelisation et simulations Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Ledieu, A

    2004-10-15

    This work is concerned with the corrosion of borosilicate glasses with variable oxide contents. The originality of this study is the complementary use of experiments and numerical simulations. This study is expected to contribute to a better understanding of the corrosion of nuclear waste confinement glasses. First, the corrosion of glasses containing only silicon, boron and sodium oxides has been studied. The kinetics of leaching show that the rate of leaching and the final degree of corrosion sharply depend on the boron content through a percolation mechanism. For some glass contents and some conditions of leaching, the layer which appears at the glass surface stops the release of soluble species (boron and sodium). This altered layer (also called the gel layer) has been characterized with nuclear magnetic resonance (NMR) and small angle X-ray scattering (SAXS) techniques. Second, additional elements have been included in the glass composition. It appears that calcium, zirconium or aluminum oxides strongly modify the final degree of corrosion so that the percolation properties of the boron sub-network is no more a sufficient explanation to account for the behavior of these glasses. Meanwhile, we have developed a theoretical model, based on the dissolution and the reprecipitation of the silicon. Kinetic Monte Carlo simulations have been used in order to test several concepts such as the boron percolation, the local reactivity of weakly soluble elements and the restructuring of the gel layer. This model has been fully validated by comparison with the results on the three oxide glasses. Then, it has been used as a comprehensive tool to investigate the paradoxical behavior of the aluminum and zirconium glasses: although these elements slow down the corrosion kinetics, they lead to a deeper final degree of corrosion. The main contribution of this work is that the final degree of corrosion of borosilicate glasses results from the competition of two opposite mechanisms

  11. Aqueous corrosion of borosilicate glasses: experiments, modeling and Monte-Carlo simulations; Alteration par l'eau des verres borosilicates: experiences, modelisation et simulations Monte-Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Ledieu, A

    2004-10-01

    This work is concerned with the corrosion of borosilicate glasses with variable oxide contents. The originality of this study is the complementary use of experiments and numerical simulations. This study is expected to contribute to a better understanding of the corrosion of nuclear waste confinement glasses. First, the corrosion of glasses containing only silicon, boron and sodium oxides has been studied. The kinetics of leaching show that the rate of leaching and the final degree of corrosion sharply depend on the boron content through a percolation mechanism. For some glass contents and some conditions of leaching, the layer which appears at the glass surface stops the release of soluble species (boron and sodium). This altered layer (also called the gel layer) has been characterized with nuclear magnetic resonance (NMR) and small angle X-ray scattering (SAXS) techniques. Second, additional elements have been included in the glass composition. It appears that calcium, zirconium or aluminum oxides strongly modify the final degree of corrosion so that the percolation properties of the boron sub-network is no more a sufficient explanation to account for the behavior of these glasses. Meanwhile, we have developed a theoretical model, based on the dissolution and the reprecipitation of the silicon. Kinetic Monte Carlo simulations have been used in order to test several concepts such as the boron percolation, the local reactivity of weakly soluble elements and the restructuring of the gel layer. This model has been fully validated by comparison with the results on the three oxide glasses. Then, it has been used as a comprehensive tool to investigate the paradoxical behavior of the aluminum and zirconium glasses: although these elements slow down the corrosion kinetics, they lead to a deeper final degree of corrosion. The main contribution of this work is that the final degree of corrosion of borosilicate glasses results from the competition of two opposite mechanisms

  12. Organizational excellence through quality governance

    OpenAIRE

    Jochem, Roland

    2008-01-01

    This paper provides an overview of an Enterprise Engineering method called IEM (Integrated Enterprise Modeling) and it describes the usage of SIX SIGMA approach for performance measurement of an enterprise. Based on these two instruments a methodology including procedure and tools is developed, which allows enterprises to define their adequate quality criteria for performance, to measure performance and quality and to derive reasonable actions to take for optimization. Determination of adequa...

  13. Measuring research excellence in the EU

    DEFF Research Database (Denmark)

    Sørensen, Mads P.; Bloch, Carter Walter; Young, Mitchell

    In 2013, the European Union unveiled its new ‘Composite Indicator for Scientific and Technological Research Excellence’, marking a turning point in how excellence is understood and used in European policy. This is not an isolated occurrence; policy-based interest in excellence is growing all over...... the world. The heightened focus on excellence and in particular, attempts to define it through quantitative indicators can have important implications for research policy and for the conduct of research itself. This paper examines how the European Union’s understanding of excellence has evolved in recent...... years, from the presentation of the Lisbon strategy in 2000 to the current Europe 2020 strategy. We find a distinct shift in the understanding of excellence and how success in the knowledge-based economy should be achieved: in the early period, excellence is a fuzzy concept, intrinsically embedded...

  14. Excel 2013 power programming with VBA

    CERN Document Server

    Walkenbach, John

    2013-01-01

    Maximize your Excel 2013 experience using VBA application development The new Excel 2013 boasts updated features, enhanced power, and new capabilities. Naturally, that means John Walkenbach returns with a new edition of his bestselling VBA Programming book and covers all the methods and tools you need to know in order to program with Excel. With this comprehensive guide, ""Mr. Spreadsheet"" shows you how to maximize your Excel experience using professional spreadsheet application development tips from his own personal bookshelf. Featuring a complete introduction to Visual Basic f

  15. The Susquehanna plant lifetime excellence program

    International Nuclear Information System (INIS)

    McNamara, R.W.

    1988-01-01

    This paper discusses how the Susquehanna plant lifetime excellence program (SPLEX) blends many of the objectives of a new managing for excellence program with plant life extension objectives to achieve excellence in the lifetime operation and availability of the two-unit Susquehanna steam electric station. Investments in lifetime excellence improvements will provide near-term, as well as plant life extension, benefits. A high-quality lifetime experience record, together with extensive, periodic technical assessments and cost-benefit analyses, will provide conclusive justification for future extensions of the unit operating licenses

  16. What every engineer should know about excel

    CERN Document Server

    Holman, J P

    2006-01-01

    INTRODUCTIONGetting the Most from ExcelConventionsOutline of MISCELLANEOUS OPERATIONS IN EXCEL AND WORDIntroductionPrint Screen or Screen DumpCustom Keyboard Setup for Symbols in WordViewing or Printing Column and Row Headings and Gridlines in ExcelAssorted InstructionsMoving Objects in Small Increments (Nudging)Formatting Objects in Word, Including WrappingFormatting Objects in ExcelUse of Photo-Editing Software in Word, Including WrappingCopying Cell Formulas: Effect of Relative and Absolute AddressesCopying Formulas by Dragging the Fill HandleShortcut for Changing the Status of Cell Address

  17. Manufactering of par-fried french-fries. Part 3: a blueprint to predict the maximum production yield

    NARCIS (Netherlands)

    Somsen, D.J.; Capelle, A.; Tramper, J.

    2004-01-01

    Very little research on the production yield of par-fried French-fries has been reported in the literature. This paper bridges the knowledge gap and outlines the development of a model to predict the maximum production yield of par-fried French-fries. This yield model can be used to calculate the

  18. Achieving excellence through organizational values.

    Science.gov (United States)

    DeForest, C; Lazio, M M; Rayder, N

    1986-03-01

    By focusing on its mission values, a hospital can enhance the quality of patient care, improve staff morale, promote cost-effectiveness, and achieve a competitive advantage in the hospital marketplace. Since 1979 Saint Joseph Hospital, Kansas City, MO, has conducted a project to clarify and apply its values to the organization's overall direction and the everyday work setting. The project has proven that a concentration on mission values can benefit both the hospital's basic "spirit" and its bottom line. Twelve guiding principles are essential to creating a values-focused hospital: 1. Begin with a commitment. 2. Identify, involve, and educate "stakeholders". 3. Identify and use appropriate resources. 4. Assess organizational needs. 5. Identify the organization's values. 6. Translate mission values into everyday language. 7. Use an explicit, visible process built with a core set of process tools. 8. Document and showcase results. 9. Link the values work to the organization's overall direction and goals and to day-to-day management issues. 10. Think and act strategically. 11. Weave values focus into the fabric of the organization to ensure permanence and long-term success. 12. Model behavior on values.

  19. ¡París!

    Directory of Open Access Journals (Sweden)

    Beatriz Caballero

    2003-01-01

    Full Text Available El día no le alcanzaba para caminarlo. Conocía cada puente, cada calle,plaza, museo, rincón, iglesia, café, y la mesa con el mejor ángulo para mirar siempre una iglesia, ojalá Saint-Germain-des-Pres, o Notre-Dame. Siempre contaba la impresión que le había causado a Bolívar ver allí cuando el papa coronó a Napoleón. Él se iba para la oficina todos los días, Luis a un taller a pintar, Antonio a estudiar ciencias políticas, yo al colegio y mamá hacía las cosas prácticas. Aprendíamos francés todos al tiempo y por la noche nos contábamos lo nuevo que cada uno había aprendido. Mamá después, cuando ya se quería volver, decía que París nos había maleado a todos. Estaba en pleno furor el cine francés de la "nueva ola", pero ella sólo me llevaba a ver películas de vaqueros pues no se fiaba de la clasificación de los periódicos.

  20. Implementation and adaption of the Computer Code ECOSYS/EXCEL for Austria as OECOSYS/EXCEL

    International Nuclear Information System (INIS)

    Hick, H.; Suda, M.; Mueck, K.

    1998-03-01

    During 1989, under contract to the Austrian Chamber of the Federal Chancellor, department VII, the radioecological forecast model OECOSYS was implemented by the Austrian Research Centre Seibersdorf on a VAX computer using VAX Fortran. OECOSYS allows the prediction of the consequences after a large scale contamination event. During 1992, under contract to the Austrian Federal Ministry of Health, Sports and Consumer Protection, department III OECOSYS - in the version of 1989 - was implemented on PC's in Seibersdorf and the Ministry using OS/2 and Microsoft -Fortran. In March 1993, the Ministry ordered an update which had become necessary and the evaluation of two exercise scenarios. Since that time the prognosis model with its auxiliary program and communication facilities is kept on stand-by and yearly exercises are performed to maintain its readiness. The current report describes the implementation and adaption to Austrian conditions of the newly available EXCEL version of the German ECOSYS prognosis model as OECOSYS. (author)

  1. Thinly disguised contempt: a barrier to excellence.

    Science.gov (United States)

    Brown-Stewart, P

    1987-04-01

    Many elements in contemporary leadership and management convey contempt for employees. "Thinly disguised contempt," a concept introduced by Peters and Austin in A Passion For Excellence, explains many barriers to the achievement of excellence in corporations across disciplines. Health care executives and managers can learn from the errors of corporate management and avoid replicating these errors in the health care industry.

  2. The Pursuit of Excellence through Education.

    Science.gov (United States)

    Ferrari, Michel, Ed.

    In this book theorists and researchers present a range of perspectives on how to promote excellence in education, providing an opportunity for expression to those who stress transformation of educational practice and those who emphasize individual abilities. In part 1, The Individual Pursuit of Excellence, the chapters are: (1) Learning from…

  3. Using Microsoft Excel to Generate Usage Statistics

    Science.gov (United States)

    Spellman, Rosemary

    2011-01-01

    At the Libraries Service Center, statistics are generated on a monthly, quarterly, and yearly basis by using four Microsoft Excel workbooks. These statistics provide information about what materials are being requested and by whom. They also give details about why certain requests may not have been filled. Utilizing Excel allows for a shallower…

  4. Procedimiento para el cálculo de los parámetros de un modelo térmico simplificado del motor asincrónico Parameter estimation procedure for an asynchronous motor simplified thermal model

    Directory of Open Access Journals (Sweden)

    Julio R Gómez Sarduy

    2011-06-01

    Full Text Available En este trabajo se presenta un método para estimar las conductancias y capacitancias de un modelo térmico simplificado del motor asincrónico, utilizando una técnica de baja invasividad. El procedimiento permite predecir el incremento de temperatura del estator del motor asincrónico, tanto para régimen dinámico como en condiciones de estabilidad térmica. Se basa en la estimación paramétrica mediante un modelo de referencia, utilizando como optimizador un algoritmo genético (AG. Se logra en definitiva obtener los parámetros del modelo térmico con un ensayo más sencillo que lo requerido por otros métodos experimentales complejos o cálculos analíticos basados en datos de diseño. El procedimiento propuesto se puede llevar a cabo en condiciones propias de la industria y resulta atractivo su empleo en el análisis de calentamiento de estas máquinas. El método se valida a partir de un estudio de caso reportado en la literatura y se aplica a un caso real en la industria, lográndose una buena precisión.In this paper, an asynchronous motor simplified thermal model method for conductances and capacitances estimation is presented. A low invasive technique is used. The developed procedure allows the stator temperature rise prediction, not only for dynamic regimes, but also in case of thermal stability. A parametric estimation is done through a reference model, using a genetic algorithm (GA as optimizing method. The thermal model parameters are finally obtained with an easer experimental work, than the required by other complex experimental methods or by analytical calculations based on design data. The proposed procedure can be carry out in the particular conditions of industrial environment. Its application is specially useful for asynchronous machine thermal analysis. Using the data of a study case reported in literature, the method validation is done, and is applied in an industrial real case, with good precision resulted from it.

  5. TOP PRIORITI QMS PRINCIPLES FOR ACHIEVING BUSINESS EXCELLENCE

    Directory of Open Access Journals (Sweden)

    Aleksandar Vujović

    2010-06-01

    Full Text Available The main target of this paper is to select top priority principles of QMS for achieving business excellence. This could be done from the standpoint of significant of principles. That means that. organization should make more attention to this principles in the way for making excellent results. This paper has been developed as a tendency of researchers in the Center for quality-Faculty of mechanical engineering in Podgorica to establish a model for improvement of business processes performances based on quality management system through comparison with top organizational performances characterized by criteria i.e. particularities of the business excellence model. Correlation of principles of the quality management system with QMS principles has been established to that effect. Weight coefficients have been also determined for each principle individually. Thereby key principles were identified, namely priorities in terms of achieving business excellence i.e. areas (principles were given priorities, that is to say principles that play the biggest part in achieving business excellence.

  6. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  7. Microsoft Office Excel 2003 Inside Out

    CERN Document Server

    Stinson, Craig

    2003-01-01

    Hey, you know your way around a spreadsheet-so now dig into Excel 2003 and really put your data to work! This supremely organized reference packs hundreds of timesaving solutions, troubleshooting tips, and handy workarounds in concise, fast-answer format. It's all muscle and no fluff. Discover the best and fastest ways to perform everyday tasks, and challenge yourself to new levels of Excel mastery! Build on what you already know about Excel and quickly dive into what's newLearn how the experts design more powerful spreadsheetsSharpen your core to advanced document editing and formatting skil

  8. Tightly sealed facility of excellent in durability

    International Nuclear Information System (INIS)

    Shirano, Kenji; Chatani, Michio; Ebe, Shinji; Shimizu, Masatoshi; Seguchi, Tadao; Fukushima, Susumu; Hirata, Masaru; Shiosawa, Ken-ichi.

    1992-01-01

    It is found that a cross linked methacryl resin using an appropriate amount of a cross linking monomer also has a useful characteristic of an excellent chemical resistance and excellent γ-ray resistance. Then in the present invention, a cross linked methacryl resin molding product comprising 60 to 98 % by weight of methyl methacrylate units and 2 to 40 % by weight of cross linking monomer units is used as a material for transparent partition walls. A tightly sealed facility having the transparent partition wall materials of excellent radiation resistance in addition to acid resistance can be attained. (T.M.)

  9. Statistical analysis with Excel for dummies

    CERN Document Server

    Schmuller, Joseph

    2013-01-01

    Take the mystery out of statistical terms and put Excel to work! If you need to create and interpret statistics in business or classroom settings, this easy-to-use guide is just what you need. It shows you how to use Excel's powerful tools for statistical analysis, even if you've never taken a course in statistics. Learn the meaning of terms like mean and median, margin of error, standard deviation, and permutations, and discover how to interpret the statistics of everyday life. You'll learn to use Excel formulas, charts, PivotTables, and other tools to make sense of everything fro

  10. 101 Ready-To-Use Excel Macros

    CERN Document Server

    Alexander, Michael

    2012-01-01

    Save time and be more productive with this helpful guide to Excel macros! While most books about Excel macros offer only minor examples, usually aimed at illustrating a particular topic, this invaluable resource provides you with the tools needed to efficiently and effectively program Excel macros immediately. Step-by-step instructions show you how to create VBA macros and explain how to customize your applications to look and work exactly as you want them to. By the end of the book, you will understand how each featured macro works, be able to reuse the macros included in the book and online,

  11. Lineær programmering med Excel

    DEFF Research Database (Denmark)

    Lynggaard, Peter

    Publikationen giver en introduktion til faget "Lineær programmering". Formulering og løsning bygger på, at modellerne opstilles og løses i et Excel-regneark. Fremgangsmåden er forklaret trin for trin, således at hæftet kan bruges som selvstudiemateriale. Indholdsfortegnelse Generelt om styring og...... planlægning Lineær programmering Excel solveren Fortolkning af udskrifter Degeneration Excel tips Opgaver med løsninger...

  12. Advanced Excel for scientific data analysis

    CERN Document Server

    De Levie, Robert

    2004-01-01

    Excel is by far the most widely distributed data analysis software but few users are aware of its full powers. Advanced Excel For Scientific Data Analysis takes off from where most books dealing with scientific applications of Excel end. It focuses on three areas-least squares, Fourier transformation, and digital simulation-and illustrates these with extensive examples, often taken from the literature. It also includes and describes a number of sample macros and functions to facilitate common data analysis tasks. These macros and functions are provided in uncompiled, computer-readable, easily

  13. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  14. Beyond accreditation: excellence in medical education.

    Science.gov (United States)

    Ahn, Eusang; Ahn, Ducksun

    2014-01-01

    Medical school accreditation is a relatively new phenomenon in Korea. The development of an accreditation body and standards for a two-tiered "Must" and "Should" system in 1997 eventually led to the implementation of a third "Excellence" level of attainment. These standards were conceived out of a desire to be able to first recognize and promote outstanding performance of medical schools, second to provide role models in medical education, and furthermore to preview the third level as potential components of the pre-existing second level for the next accreditation cycle. It is a quality-assurance mechanism that, while not required for accreditation itself, pushes medical schools to go beyond the traditional requirements of mere pass-or-fail accreditation adequacy, and encourages schools to deliver an unprecedented level of medical education. The Association for Medical Education in Europe developed its own third-tier system of evaluation under the ASPIRE project, with many similar goals. Due to its advanced nature and global scope, the Korean accreditation body has decided to implement the ASPIRE system in Korea as well.

  15. Firm characteristics and excellence in integrated reporting

    Directory of Open Access Journals (Sweden)

    Natasha Buitendag

    2017-02-01

    Full Text Available Background: Integrated reporting has attracted much attention in the past few years, and South Africa has taken the lead in its development worldwide. An annual survey is published by Ernst & Young regarding the quality of the integrated reports of the top 100 entities listed on the Johannesburg Stock Exchange (JSE. Aim: The study on which this article is based was aimed at determining whether the assessment of an entity’s characteristics can predetermine the quality of the integrated report generated by that entity. Setting: This article focuses on an analysis of the integrated reporting of the top 100 entities listed on JSE for the financial years ending in 2013, 2014 and 2015. Methods: Comparison of categorical variables, mixed-model repeated measures ANOVA and generalised estimating equations were applied to identify the best classificators to distinguish between excellent integrated reporting and those reports where progress could still be made. Results: The results show that the type of industry the entity finds itself in, the size and profitability of the entity, as well as the composition of the members of the board, have an effect on the quality of the integrated report. Conclusion: Our results indicated that the type of industry, size of an entity, the profitability and composition of the board of directors, all have an effect on the quality of the integrated reporting. Our evidence will assist current and prospective stakeholders in evaluating the expected quality of an entity’s integrated report, through the evaluation of certain firm characteristics.

  16. Excellence in the Knowledge-Based Economy: From Scientific to Research Excellence

    Science.gov (United States)

    Sørensen, Mads P.; Bloch, Carter; Young, Mitchell

    2016-01-01

    In 2013, the European Union (EU) unveiled its new "Composite Indicator for Scientific and Technological Research Excellence." This is not an isolated occurrence; policy-based interest in excellence is growing all over the world. The heightened focus on excellence and, in particular, attempts to define it through quantitative indicators…

  17. What Makes an Excellent Lecturer? Academics' Perspectives on the Discourse of "Teaching Excellence" in Higher Education

    Science.gov (United States)

    Wood, Margaret; Su, Feng

    2017-01-01

    In the context of the Teaching Excellence Framework (TEF), we examine academics' perspectives on the discourse of "teaching excellence" based on an empirical study with 16 participants from five post-1992 universities. The article reports the findings on academics' views of the term and concept of "teaching excellence",…

  18. Improved Satellite-based Photosysnthetically Active Radiation (PAR) for Air Quality Studies

    Science.gov (United States)

    Pour Biazar, A.; McNider, R. T.; Cohan, D. S.; White, A.; Zhang, R.; Dornblaser, B.; Doty, K.; Wu, Y.; Estes, M. J.

    2015-12-01

    One of the challenges in understanding the air quality over forested regions has been the uncertainties in estimating the biogenic hydrocarbon emissions. Biogenic volatile organic compounds, BVOCs, play a critical role in atmospheric chemistry, particularly in ozone and particulate matter (PM) formation. In southeastern United States, BVOCs (mostly as isoprene) are the dominant summertime source of reactive hydrocarbon. Despite significant efforts in improving BVOC estimates, the errors in emission inventories remain a concern. Since BVOC emissions are particularly sensitive to the available photosynthetically active radiation (PAR), model errors in PAR result in large errors in emission estimates. Thus, utilization of satellite observations to estimate PAR can help in reducing emission uncertainties. Satellite-based PAR estimates rely on the technique used to derive insolation from satellite visible brightness measurements. In this study we evaluate several insolation products against surface pyranometer observations and offer a bias correction to generate a more accurate PAR product. The improved PAR product is then used in biogenic emission estimates. The improved biogenic emission estimates are compared to the emission inventories over Texas and used in air quality simulation over the period of August-September 2013 (NASA's Discover-AQ field campaign). A series of sensitivity simulations will be performed and evaluated against Discover-AQ observations to test the impact of satellite-derived PAR on air quality simulations.

  19. Rural Math Excel Partnership (RMEP) Project Final Performance Report

    Science.gov (United States)

    Harmon, Hobart; Tate, Veronica; Stevens, Jennifer; Wilborn, Sandy; Adams, Sue

    2018-01-01

    The goal of the Rural Math Excel Partnership (RMEP) project, a development project funded by the U.S. Department of Education Investing in Innovation (i3) grant program, was to develop a model of shared responsibility among families, teachers, and communities in rural areas as collective support for student success in and preparation for advanced…

  20. Predictors of excellent response to lithium

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Hellmund, Gunnar; Andersen, Per Kragh

    2011-01-01

    The aim of this study was to identify sociodemographic and clinical predictors of excellent response, that is, 'cure' of future affective episodes, to lithium in monotherapy. We used nationwide registers to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings...... who were prescribed lithium from 1995 to 2006 in Denmark (N=3762). Excellent lithium responders were defined as patients who after a stabilization lithium start-up period of 6 months, continued lithium in monotherapy without getting hospitalized. The rate of excellent response to lithium...... with somatic comorbidity had increased rates of non-response to lithium compared with patients without somatic comorbidity (HR=1.23, 95% CI: 1.00-1.52).It is concluded that the prevalence of excellent response to lithium monotherapy is low and such patients are characterized by few earlier psychiatric...

  1. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  2. QUALITY AWARDS: AN IMAGE OF BUSINESS EXCELLENCE

    Directory of Open Access Journals (Sweden)

    Ilies Liviu

    2015-07-01

    Full Text Available Across the world, increasingly more governmental organizations and industrial are doing everything possible to promote quality and to survive, the basic principle remains customer satisfaction and even more than that, it speaks of the principle of customer delight. In this sense, quality has become the source of sustained competitive advantage that provides organizations the supremacy of the global markets characterized by competition which becoming more and more intensified. Juran, one of the highest quality gurus say that “just as the twentieth century was the century of productivity, the twenty-first century will be the quality century” which is a very relevant and comprehensive statement of the economic reality of the past and a profound forecast for future business of the twenty-first century. In this regard, in order to achieve this competitive advantage, quality must be managed and this is accomplished through Total Quality Management (TQM. Quality awards models are instruments of total quality management through which quality can be assessed and improved, thus, knowing the quality awards models is critical for findings the new ways to improve the quality and performance of the organizations. The present paper aims to illustrate the best practices on quality improvement in this respect we intend to present the general framework of the quality awards for business excellence. In this sense we present the most important international quality awards, namely: "Malcolm Baldrige National Quality Award", "European Quality Award" and “Romanian Quality Award J. M. Juran". For this purpose we used as main sources of analyzing the structure and the operation mode of these three important quality awards, Juran's work (which is probably the most important work in the field of quality and other relevant sources in total quality management which treats issues related to quality awards and also we used as sources of updated information the official

  3. Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research.

    Science.gov (United States)

    Tanavalee, Chotetawan; Luksanapruksa, Panya; Singhatanadgige, Weerasak

    2016-06-01

    Microsoft Excel (MS Excel) is a commonly used program for data collection and statistical analysis in biomedical research. However, this program has many limitations, including fewer functions that can be used for analysis and a limited number of total cells compared with dedicated statistical programs. MS Excel cannot complete analyses with blank cells, and cells must be selected manually for analysis. In addition, it requires multiple steps of data transformation and formulas to plot survival analysis graphs, among others. The Megastat add-on program, which will be supported by MS Excel 2016 soon, would eliminate some limitations of using statistic formulas within MS Excel.

  4. 101 ready-to-use Excel formulas

    CERN Document Server

    Alexander, Michael

    2014-01-01

    Mr. Spreadsheet has done it again with 101 easy-to-apply Excel formulas 101 Ready-to-Use Excel Formulas is filled with the most commonly-used, real-world Excel formulas that can be repurposed and put into action, saving you time and increasing your productivity. Each segment of this book outlines a common business or analysis problem that needs to be solved and provides the actual Excel formulas to solve the problem-along with detailed explanation of how the formulas work. Written in a user-friendly style that relies on a tips and tricks approach, the book details how to perform everyday Excel tasks with confidence. 101 Ready-to-Use Excel Formulas is sure to become your well-thumbed reference to solve your workplace problems. The recipes in the book are structured to first present the problem, then provide the formula solution, and finally show how it works so that it can be customized to fit your needs. The companion website to the book allows readers to easily test the formulas and provides visual confirmat...

  5. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    NARCIS (Netherlands)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced

  6. Assessing excellence in translational cancer research: a consensus based framework.

    Science.gov (United States)

    Rajan, Abinaya; Caldas, Carlos; van Luenen, Henri; Saghatchian, Mahasti; van Harten, Wim H

    2013-10-29

    It takes several years on average to translate basic research findings into clinical research and eventually deliver patient benefits. An expert-based excellence assessment can help improve this process by: identifying high performing Comprehensive Cancer Centres; best practices in translational cancer research; improving the quality and efficiency of the translational cancer research process. This can help build networks of excellent Centres by aiding focused partnerships. In this paper we report on a consensus building exercise that was undertaken to construct an excellence assessment framework for translational cancer research in Europe. We used mixed methods to reach consensus: a systematic review of existing translational research models critically appraised for suitability in performance assessment of Cancer Centres; a survey among European stakeholders (researchers, clinicians, patient representatives and managers) to score a list of potential excellence criteria, a focus group with selected representatives of survey participants to review and rescore the excellence criteria; an expert group meeting to refine the list; an open validation round with stakeholders and a critical review of the emerging framework by an independent body: a committee formed by the European Academy of Cancer Sciences. The resulting excellence assessment framework has 18 criteria categorized in 6 themes. Each criterion has a number of questions/sub-criteria. Stakeholders favoured using qualitative excellence criteria to evaluate the translational research "process" rather than quantitative criteria or judging only the outputs. Examples of criteria include checking if the Centre has mechanisms that can be rated as excellent for: involvement of basic researchers and clinicians in translational research (quality of supervision and incentives provided to clinicians to do a PhD in translational research) and well designed clinical trials based on ground-breaking concepts (innovative

  7. Excellence in fleet combat replacement squadrons: predicting carrier qualification success

    OpenAIRE

    Smith, Martin P.

    1988-01-01

    This thesis presents a two-part analysis of excellence criteria for fleet combat replacement squadrons. Part one focuses on the qualitative issues and management techniques identified in outstanding fleet combat replacement squadrons. Part two develops and presents a regression model for predicting a fleet replacement squadron pilot's carrier qualification grade. The model was derived using standard linear regression techniques and the SPSSx software package of the Naval Postgraduate School. ...

  8. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  9. SARNET: Severe accident research network of excellence

    International Nuclear Information System (INIS)

    Albiol, Thierry; Haste, Tim; Dorsselaere, Jean-Pierre van

    2007-01-01

    51 organizations network in SARNET (Severe Accident Research NETwork of Excellence) their capacities of research in order to resolve the most important remaining uncertainties for enhancing, in regard of Severe Accidents (SA), the safety of existing and future Nuclear Power Plants (NPPs). This project, co-funded by the European Commission (EC), has been defined in order to optimise the use of the available means and to constitute sustainable research groups in the European Union. SARNET tackles the fragmentation that exists between the different R and D national programmes, in defining common research programmes and developing common computer tools and methodologies for safety assessment. SARNET comprises most of the actors involved in SA research in Europe (plus Canada). To reach these objectives, all the organizations networked in SARNET contribute to a so-called Joint Programme of Activities (JPA), which consists in: Implementing an advanced communication tool for accessing all project information, fostering exchange of information, and managing documents; Harmonizing and re-orienting the research programmes; Jointly analysing the experimental results provided by research programmes in order to elaborate a common understanding of relevant phenomena; Developing the ASTEC code (integral computer code used to predict the NPP behaviour during a postulated SA), which capitalizes in terms of physical models the knowledge produced within SARNET; Developing Scientific Databases, in which all the results of research programmes are stored in a common format (DATANET); Developing a common methodology for Probabilistic Safety Assessment (PSA) of NPPs; Developing courses and writing a text book on SA for students and researchers; Promoting personnel mobility between various European organizations. After the first period (2004-2008), co-funded by the EC, the network will progressively evolve toward self-sustainability. The bases for such an evolution, still under discussion

  10. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes

    Science.gov (United States)

    Magnussen, Synnøve; Hadler-Olsen, Elin; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja E.; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg

    2014-01-01

    Background The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells’ expression level of uPAR affected the activity of gelatinolytic enzymes. Methods The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM) proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography. Results We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. Conclusions Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the

  11. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  12. Creating cultures of excellence: Strategies and outcomes

    Directory of Open Access Journals (Sweden)

    Michael Mintrom

    2014-12-01

    Full Text Available Research findings on effective support for learning, the development of expertise, and the psychology of success suggest that the pursuit of excellence is teachable. Within the emerging field of research and practice termed “the scholarship of teaching and learning,” considerable effort has been made to document the practices of teachers who, by various measures, have been deemed excellent. In contrast, no effort has been made to codify how students can be trained to self-consciously build behaviors that generate excellent outcomes. This article reports on a multi-year effort to create cultures of excellence among cohorts of graduate students. A statistical analysis of subsequent student performance on a significant, related task indicates that explicitly promoting a culture of excellence among course participants can have a positive and sustained impact on their individual practices. Comments from subsequent student reflections further support this claim. The teaching strategies reported here could be refined, replicated, and reinvented to good effect across higher education. They are also of special relevance to those delivering professional development training to early- and mid-career professionals.

  13. Evaluation of Business Excellence among Halal Certified Food Manufacturers in Malaysia

    OpenAIRE

    Masrom Nor Ratna binti; Mohd Rasi Raja Zuraidah binti Raja; Daut Badru At Tamam bin

    2017-01-01

    Business excellence is a key tool to improve the efficiency of the company. Through the business excellence model, the organization can execute their strategies to determine, forecast and survive in highly competitive market. This paper presents on identifying those elements in business excellence model (leadership, strategy and planning, customer focus, measurement, analysis, and knowledge management, operation focus) this paper provides empirical support for halal food certified companies r...

  14. Planeering kui kaasaegne teos par excellence : kas tulevikku saab välja mõelda? = The plan as a contenporary work par excellence : can the future be made up? / Toomas Tammis

    Index Scriptorium Estoniae

    Tammis, Toomas, 1969-

    2011-01-01

    Tulevikku saab kavandada läbi visioonide, läbi erinevate erialade teadmistest kokku lõimunud loomingulise akti, mis ei saa kunagi olla liiga täpne. Planeering saab olla teatav süsteem, mis suudab lõputult produtseerida väikseid üsna täpselt koha- ja keskkonnatundlikke produkte, jäädes ise pidevasse loomisse ning pooleliolekusse, olles pidevas interaktsioonis ühiskonnaga viimast lõputult monitoorides ja muutes

  15. Model of a plasma without collisions in a cylindrical geometry by the study of the motions of the particles (1960); Modele d'un plasma sans collisions dans une geometrie cylindrique par l'etude des mouvements de particules (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Rebut, P H [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee

    1960-07-01

    The Boltzmann equation for a group of particles in the absence of collisions may be written df/dt = 0, where f is the distribution function in the phase space. This equation means that f is an individual motion constant. This leads to a study, of the paths and to a research of the first integrals of the differential system related to them. This study leads also to a confinement condition on the velocities of a particle. The following step is related to the theoretical study of some distribution functions and of the resulting consequences. A differential system is obtained, giving density and magnetic and electric fields. This system has been in a number of cases solved by a digital computer. This solution allows an experimental comparison to be made. The first integrals obtained are still valid when magnetic 'screw-type' fields are concerned, which results in the obtention of a type of helicoidal deformation and of a stability criteria with respect to these deformations. (author) [French] L'equation de Boltzmann pour un groupe de particules en l'absence de collision peut s'ecrire df/dt = 0, ou f est la fonction de distribution dans l'espace des phases. Cette equation signifie que f est une constante du mouvement individuel. On est donc amene a etudier les trajectoires et a rechercher des integrales premieres du systeme differentiel qui leur est lie; cette etude conduit aussi a une condition de confinement portant sur les vitesses d'une particule. L'etape suivante se rapporte a l'etude theorique de certaines fonctions de distribution et des consequences qui en decoulent. On arrive a un systeme differentiel donnant densite, champs magnetiques et electriques, systeme qui a ete resolu dans un certain nombre de cas par une machine a calculer digitale. Cette resolution permet une confrontation experimentale. Les integrales premieres obtenues restent encore valables lors de champs magnetiques en 'vis'; il en resulte l'obtention d'un type de deformation helicoidale et d

  16. Auto Draw from Excel Input Files

    Science.gov (United States)

    Strauss, Karl F.; Goullioud, Renaud; Cox, Brian; Grimes, James M.

    2011-01-01

    The design process often involves the use of Excel files during project development. To facilitate communications of the information in the Excel files, drawings are often generated. During the design process, the Excel files are updated often to reflect new input. The problem is that the drawings often lag the updates, often leading to confusion of the current state of the design. The use of this program allows visualization of complex data in a format that is more easily understandable than pages of numbers. Because the graphical output can be updated automatically, the manual labor of diagram drawing can be eliminated. The more frequent update of system diagrams can reduce confusion and reduce errors and is likely to uncover symmetric problems earlier in the design cycle, thus reducing rework and redesign.

  17. Achieving engineering excellence at Palo Verde

    International Nuclear Information System (INIS)

    Prawlocki, F.C.

    1989-01-01

    Early in 1988, the management of the newly formed Palo Verde Nuclear Generating Station (PVNGS) Engineering and Construction Division was faced with a dilemma: how to build a competent, confident, efficient engineering organization in the face of increasing requirements and tightened fiscal controls. This paper discusses steps taken by Palo Verde to address actions taken to effect a smooth transition from construction to operations and the development of the Engineering Excellence Program. The Engineering Excellence Program will continue to evolve over time as the number of the NED's [Nuclear Engineering Department] personnel grown and processes are changed over the course of the next few years. As tasks from the Engineering Excellence Program action plan are completed, the results achieved are expected to be integrated into the routine business of the NED

  18. ParShield: A computer program for calculating attenuation parameters of the gamma rays and the fast neutrons

    International Nuclear Information System (INIS)

    Elmahroug, Y.; Tellili, B.; Souga, C.; Manai, K.

    2015-01-01

    Highlights: • Description of the theoretical method used by the ParShield program. • Description of the ParShield program. • Test and validation the ParShield program. - Abstract: This study aims to present a new computer program called ParShield which determines the neutron and gamma-ray shielding parameters. This program can calculate the total mass attenuation coefficients (μ t ), the effective atomic numbers (Z eff ) and the effective electron densities (N eff ) for gamma rays and it can also calculate the effective removal cross-sections (Σ R ) for fast neutrons for mixtures and compounds. The results obtained for the gamma rays by using ParShield were compared with the results calculated by the WinXcom program and the measured results. The obtained values of (Σ R ) were tested by comparing them with the measured results,the manually calculated results and with the results obtained by using MERCSFN program and an excellent agreement was found between them. The ParShield program can be used as a fast and effective tool to choose and compare the shielding materials, especially for the determination of (Z eff ) and (N eff ), there is no other programs in the literature which can calculate

  19. Excellence in the knowledge-based economy: from scientific to research excellence

    DEFF Research Database (Denmark)

    Sørensen, Mads P.; Bloch, Carter Walter; Young, Mitchell

    2016-01-01

    In 2013, the European Union (EU) unveiled its new ‘Composite Indicator for Scientific and Technological Research Excellence’. This is not an isolated occurrence; policy-based interest in excellence is growing all over the world. The heightened focus on excellence and, in particular, attempts...... to define it through quantitative indicators can have important implications for research policy and for the conduct of research itself. This paper examines how the EU's understanding of excellence has evolved in recent years, from the presentation of the Lisbon strategy in 2000 to the current Europe 2020...... strategy. We find a distinct shift in the understanding of excellence and how success in the knowledge-based economy should be achieved: in the early period, excellence is a fuzzy concept, intrinsically embedded in research and researchers and revealed by peer review. In the later period, excellence...

  20. Excel formulas and functions for dummies

    CERN Document Server

    Bluttman, Ken

    2013-01-01

    Learn to use Excel for practical, day-to-day calculations Excel is a powerful program with more than 300 built-in functions that can be used to perform an almost infinite number of calculations. This friendly book shows you how to use the 150 most valuable ones in real-world situations: to compare the cost of buying vs. leasing a car, calculate classroom grades, or evaluate investment performance, for example. Another 85 specialized functions are also described. Detailed, step-by-step instructions help you understand how functions work within formulas and how you can use them t

  1. Excellent fruits of national research and development

    International Nuclear Information System (INIS)

    2008-12-01

    This book introduces 100 excellent fruits of research and development in Korea. Such as. It show the titles of 100 excellent fruits about technology of hope to give people healthy life, technology of product and abundance to enrich resource, technology to make green growth and sound society, next service technology to communicate with network, new electron technology to brings life change, technology to draw innovation of industrial fields, technology to build higher value-added product with new fusion materials and technology to share and to create future knowledge.

  2. Critical self-evaluation for excellence

    International Nuclear Information System (INIS)

    Mullee, G.R.

    1988-01-01

    This paper discusses the use of critical self-evaluation of performance as a stimulus for excellence. Self-evaluation inherently provides acceptance and ownership of a problem, thereby motivating change. Some of the key elements of self-evaluation are discussed such as unbiased observations and appropriate performance standards. As circumstances change, an ongoing self-appraisal approach provides continuing feedback to maintain and further excellence. Two examples of critical self-evaluation in use at the Tennessee Valley Authority (TVA) are discussed

  3. Confirmatory factor analysis using Microsoft Excel.

    Science.gov (United States)

    Miles, Jeremy N V

    2005-11-01

    This article presents a method for using Microsoft (MS) Excel for confirmatory factor analysis (CFA). CFA is often seen as an impenetrable technique, and thus, when it is taught, there is frequently little explanation of the mechanisms or underlying calculations. The aim of this article is to demonstrate that this is not the case; it is relatively straightforward to produce a spreadsheet in MS Excel that can carry out simple CFA. It is possible, with few or no programming skills, to effectively program a CFA analysis and, thus, to gain insight into the workings of the procedure.

  4. Preparing data for analysis using microsoft Excel.

    Science.gov (United States)

    Elliott, Alan C; Hynan, Linda S; Reisch, Joan S; Smith, Janet P

    2006-09-01

    A critical component essential to good research is the accurate and efficient collection and preparation of data for analysis. Most medical researchers have little or no training in data management, often causing not only excessive time spent cleaning data but also a risk that the data set contains collection or recording errors. The implementation of simple guidelines based on techniques used by professional data management teams will save researchers time and money and result in a data set better suited to answer research questions. Because Microsoft Excel is often used by researchers to collect data, specific techniques that can be implemented in Excel are presented.

  5. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1 in breast cancer invasion: signaling partners, hierarchy and physiological significance.

    Directory of Open Access Journals (Sweden)

    Irit Cohen

    Full Text Available BACKGROUND: While protease-activated-receptor 1 (PAR(1 plays a central role in tumor progression, little is known about the cell signaling involved. METHODOLOGY/PRINCIPAL FINDINGS: We show here the impact of PAR(1 cellular activities using both an orthotopic mouse mammary xenograft and a colorectal-liver metastasis model in vivo, with biochemical analyses in vitro. Large and highly vascularized tumors were generated by cells over-expressing wt hPar1, Y397Z hPar1, with persistent signaling, or Y381A hPar1 mutant constructs. In contrast, cells over-expressing the truncated form of hPar1, which lacks the cytoplasmic tail, developed small or no tumors, similar to cells expressing empty vector or control untreated cells. Antibody array membranes revealed essential hPar1 partners including Etk/Bmx and Shc. PAR(1 activation induces Etk/Bmx and Shc binding to the receptor C-tail to form a complex. Y/A mutations in the PAR(1 C-tail did not prevent Shc-PAR(1 association, but enhanced the number of liver metastases compared with the already increased metastases obtained with wt hPar1. We found that Etk/Bmx first binds via the PH domain to a region of seven residues, located between C378-S384 in PAR(1 C-tail, enabling subsequent Shc association. Importantly, expression of the hPar1-7A mutant form (substituted A, residues 378-384, which is incapable of binding Etk/Bmx, resulted in inhibition of invasion through Matrigel-coated membranes. Similarly, knocking down Etk/Bmx inhibited PAR(1-induced MDA-MB-435 cell migration. In addition, intact spheroid morphogenesis of MCF10A cells is markedly disrupted by the ectopic expression of wt hPar1. In contrast, the forced expression of the hPar1-7A mutant results in normal ball-shaped spheroids. Thus, by preventing binding of Etk/Bmx to PAR(1 -C-tail, hPar1 oncogenic properties are abrogated. CONCLUSIONS/SIGNIFICANCE: This is the first demonstration that a cytoplasmic portion of the PAR(1 C-tail functions as a scaffold

  6. In vivo preclinical low field MRI monitoring of tumor growth following a suicide gene therapy in an ortho-topic mice model of human glioblastoma;Controle par IRM bas champ in vivo de l'efficacite d'une therapie genique par gene suicide dans un modele murin de glioblastome orthotopique

    Energy Technology Data Exchange (ETDEWEB)

    Breton, E.; Goetz, Ch.; Aubertin, G.; Constantinesco, A.; Choquet, Ph. [Service de biophysique et medecine nucleaire, hopital de Hautepierre, CHRU de Strasbourg, 67 - Strasbourg (France); Institut de mecanique des fluides et des solides, CNRS, universite de Strasbourg, 67 - Strasbourg (France); Kintz, J.; Accart, N.; Grellier, B.; Erbs, Ph.; Rooke, R. [Transgene SA, parc d' innovation, 67 - Illkirch Graffenstaden (France)

    2010-03-15

    Purpose The aim of this study was to monitor in vivo with low field MRI growth of a murine ortho-topic glioma model following a suicide gene therapy. Methods The gene therapy consisted in the stereotactic injection in the mice brain of a modified vaccinia virus Ankara (M.V.A.) vector encoding for a suicide gene (FCU1) that transforms a non toxic pro-drug 5-fluoro-cytosine (5-F.C.) to its highly cytotoxic derivatives 5-fluorouracil (5-F.U.) and 5-fluoro-uridine-5 monophosphate (5-F.U.M.P.). Using a warmed-up imaging cell, sequential 3D T1 and T2 0.1T MRI brain examinations were performed on 16 Swiss female nu/nu mice bearing ortho-topic human glioblastoma (U 87-MG cells). The 6-week in vivo MRI follow-up consisted in a weekly measurement of the intracerebral tumor volume leading to a total of 65 examinations. Mice were divided in four groups: sham group (n = 4), sham group treated with 5-F.C. only (n = 4), sham group with injection of M.V.A.-FCU1 vector only (n = 4), therapy group administered with M.V.A.-FCU1 vector and 5-F.C. (n = 4). Measurements of tumor volumes were obtained after manual segmentation of T1- and T2-weighted images. Results Intra-observer and inter-observer tumor volume measurements show no significant differences. No differences were found between T1 and T2 volume tumor doubling times between the three sham groups. A significant statistical difference (p < 0.05) in T1 and T2 volume tumor doubling times between the three sham groups and the animals treated with the intratumoral injection of M.V.A.-FCU1 vector in combination with 2 weeks per os 5-F.C. administration was demonstrated. Conclusion Preclinical low field MRI was able to monitor efficacy of suicide gene therapy in delaying the tumor growth in an in vivo mouse model of ortho-topic glioblastoma. (authors)

  7. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Enterprise-Wide Process & Performance Excellence:

    DEFF Research Database (Denmark)

    Edgeman, Rick; Kristensen, Kai; Eskildsen, Jacob Kjær

    2013-01-01

    Program value proposition, content, organization, and strategy are elaborated herein. This elaboration is the result of careful study of business and social trends, along with careful listening to collaborating enterprises. It is in this latter sense that the Enterprise-Wide Process & Performance...... Excellence certificate program is a product of a co-creation process....

  9. Introduction to 3D Graphics through Excel

    Science.gov (United States)

    Benacka, Jan

    2013-01-01

    The article presents a method of explaining the principles of 3D graphics through making a revolvable and sizable orthographic parallel projection of cuboid in Excel. No programming is used. The method was tried in fourteen 90 minute lessons with 181 participants, which were Informatics teachers, undergraduates of Applied Informatics and gymnasium…

  10. Using Excel in Teacher Education for Sustainability

    Science.gov (United States)

    Aydin, Serhat

    2016-01-01

    In this study, the feasibility of using Excel software in teaching whole Basic Statistics Course and its influence on the attitudes of pre-service science teachers towards statistics were investigated. One hundred and two pre-service science teachers in their second year participated in the study. The data were collected from the prospective…

  11. Textbooks for Responsible Data Analysis in Excel

    Science.gov (United States)

    Garrett, Nathan

    2015-01-01

    With 27 million users, Excel (Microsoft Corporation, Seattle, WA) is the most common business data analysis software. However, audits show that almost all complex spreadsheets have errors. The author examined textbooks to understand why responsible data analysis is taught. A purposeful sample of 10 textbooks was coded, and then compared against…

  12. Marketing and branding your Centers of Excellence.

    Science.gov (United States)

    Herrod, K G

    2001-01-01

    Branding your Centers of Excellence requires more than simply advertising. Developing a strong brand involves completing your due diligence. Adequate reparation and strategic planning will help your organization successfully navigate looming pitfalls, overcome competitive pressures, and make a direct hit with physicians and consumers.

  13. Centers of Excellence Contribution to Knowledge Augmentation

    International Nuclear Information System (INIS)

    Mignone, O.

    2016-01-01

    Full text: Knowledge management is a key need of the nuclear industry to cope with the knowledge limited augmentation and the risks of knowledge loss due to a number of reasons, such as: staff attrition, organizational changes, upgraded technologies, new projects implementation, and the nuclear power evolution in recent years (i.e., post-Fukushima upgrades). This document describes the contribution of nuclear centers of excellence to knowledge augmentation. The effective implementation of nuclear centers of excellence is a key success factor for the knowledge management programme of nuclear organizations. This document, is based on a real example of operating organization approach in launching such initiative for staff knowledge augmentation and performance improvement. Eventually, any type of organizations in the nuclear sector could apply the proposed technique to reach better knowledge usage. The nuclear centers of excellence are a key knowledge management initiative for the learning organizations that are caring about organizational intellectual capital and striving for performance improvement. The nuclear centers of excellence can be realized as a forum to exchange ideas, knowledge, information, experiences; to collect lessons learned; and to identify areas for improvement where further organizational competence building is needed. Usual realization of this initiative is going through an active staff involvement in knowledge sharing in a form of different technical communities of practice focusing on specific knowledge domains. (author

  14. Key components when teaching for excellence

    NARCIS (Netherlands)

    Wolfensberger, Marca; Wolfensberger, Marca; Drayer, Lyndsay; Volker, Judith

    2014-01-01

    The Research Centre for Talent Development in Higher Education and Society, based at Hanze University of Applied Sciences in the Netherlands, organised the first international conference “Evoking Excellence in Higher Education and Beyond”. This conference brought together scholars and educators from

  15. Managing service excellence. Internal customer service training

    International Nuclear Information System (INIS)

    McAnulty, P.C.

    1991-01-01

    WHO ARE OUR CUSTOMERS? Electric Users, regulators, vendors, suppliers, or our own employees? The answer is ALL exclamation point They are all customers. Regardless if they are external or internal customers, one must focus on quality of service delivery in order to maintain customer satisfaction. The most successful companies are quickly realizing that managing SERVICE EX NCE is our only future. For the next decade, the issue of service quality will exceed the issue of productivity. It is very easy to see that the business behind a utility is serving our electric consumers. However, internal customer service - service excellence to employees inside a company is the foundation for success. This paper describes a training program that is being implemented across Duke Power for employees on internal customer service. How we provide service to each other within a company impacts service quality to our external customers. This training refocuses behaviors and perceptions so to concentrate on quality service delivery to our internal customers - our employees. We all have positive and negative experiences with obtaining quality service by either external organizations or internal employees. Therefore, we start with a common foundation. Whether it be a supplier, vendor, or a station administrative group, we have experienced either excellent or poor customer service. All of us have potential in managing the delivery of excellent customer service. However, many of us may need new perspectives so to add depth with which we view and manage service excellence to our internal customers

  16. Vyacheslav (Slava) Klimov (1945-2017): A scientist par excellence, a great human being, a friend, and a Renaissance man.

    Science.gov (United States)

    Allakhverdiev, Suleyman I; Zharmukhamedov, Sergey K; Rodionova, Margarita V; Shuvalov, Vladimir A; Dismukes, Charles; Shen, Jian-Ren; Barber, James; Samuelsson, Göran; Govindjee

    2018-04-01

    Vyacheslav Vasilevich (V.V.) Klimov (or Slava, as most of us called him) was born on January 12, 1945 and passed away on May 9, 2017. He began his scientific career at the Bach Institute of Biochemistry of the USSR Academy of Sciences (Akademy Nauk (AN) SSSR), Moscow, Russia, and then, he was associated with the Institute of Photosynthesis, Pushchino, Moscow Region, for about 50 years. He worked in the field of biochemistry and biophysics of photosynthesis. He is known for his studies on the molecular organization of photosystem II (PSII). He was an eminent scientist in the field of photobiology, a well-respected professor, and, above all, an outstanding researcher. Further, he was one of the founding members of the Institute of Photosynthesis in Pushchino, Russia. To most, Slava Klimov was a great human being. He was one of the pioneers of research on the understanding of the mechanism of light energy conversion and of water oxidation in photosynthesis. Slava had many collaborations all over the world, and he is (and will be) very much missed by the scientific community and friends in Russia as well as around the World. We present here a brief biography and some comments on his research in photosynthesis. We remember him as a friendly and enthusiastic person who had an unflagging curiosity and energy to conduct outstanding research in many aspects of photosynthesis, especially that related to PSII.

  17. ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation

    Science.gov (United States)

    Donczew, Magdalena; Mackiewicz, Paweł; Wróbel, Agnieszka; Flärdh, Klas; Zakrzewska-Czerwińska, Jolanta

    2016-01-01

    In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces. To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at the time of ParA accumulation and Z-ring formation. We demonstrated that both ParA and ParB affect the rate of hyphal extension. Additionally, we showed that ParA promotes the formation of massive nucleoprotein complexes by ParB. We also showed that FtsZ ring assembly is affected by the ParB protein and/or unsegregated DNA. Our results indicate the existence of a checkpoint between the extension and septation of sporogenic hyphae that involves the ParA and ParB proteins. PMID:27248800

  18. Numerical analysis of the influence of PAR unit elevation within a vessel on its performance

    International Nuclear Information System (INIS)

    Kotouč, Miroslav

    2011-01-01

    On the basis of successful validation of the MELCOR code on several experiments from the international OECD/NEA programme THAI, a numerical parametric study has been conducted at NRI Řež evaluating the influence of PAR's vertical position within a vessel on its performance. Simulations were carried out for an Areva PAR unit which was considered to be placed at 5 different elevations in the THAI test vessel, the sixth simulation comprised a model of blower, simulating thus forced convection. The initial conditions were those of the THAI HR-12 test, which was characterized by steam-saturated atmosphere at elevated pressure and temperature. The results show that the overall hydrogen mass recombined monotonically decreases with PAR elevation. This behavior is due to hot, light and hydrogen-lean plume, coming out from the PAR outlet, which, due to buoyancy forces, eventually fills the upper part of the vessel and prevents thus the PAR unit from efficient operation (if the latter is placed near the top). It was also demonstrated that the effect of forced convection is favorable since it breaks the gas stratification and increases thus hydrogen concentration at the PAR inlet. (author)

  19. Permeability Damage Due to Asphaltene Deposition : Experimental and Modeling Aspects Endommagement d'un milieu poreux par dépôts d'asphaltènes : expériences et modélisation

    Directory of Open Access Journals (Sweden)

    Minssieux L.

    2006-12-01

    Full Text Available The flow properties of several asphaltenic crudes were studied at reservoir temperature in rocks of different morphology and mineralogy. The experiments performed showed a progressive reduction in permeability to oil during injection, varying in rate according to the system considered. The existence of organic deposits was verified by Rock-Evalpyrolysis measurements made on sections of samples taken at the end of flow at different distances from the entry face. This technique enables the profile of the deposits to be quantified. The interpretation of the permeability damage experiments and their simulation are treated by comparing the asphaltenes in oil to colloidal particles in suspension, capable of being deposited at the surface of the pores and thus reducing the permeability of the porous medium. The first simulations were carried out using the PARISIFP particle damage model, which has recently been extended to the case of multi-layer deposition. A satisfactory qualitative agreement is observed with the experimental results. Les propriétés d'écoulement de plusieurs bruts asphalténiques ont été étudiées à la température du réservoir d'origine dans des roches de morphologie et minéralogie différentes. Les expériences réalisées mettent en évidence une réduction progressive de la perméabilité à l'huile au cours de l'injection, plus ou moins rapide selon les cas. L'existence de dépôts organiques a été vérifiée par des mesures de pyrolyse Rock-Evaleffectuées sur des sections d'échantillons prélevées en fin d'écoulement à différentes distances de la face d'entrée. Cette technique permet de quantifier le profil des dépôts. L'interprétation des expériences de colmatage et leur simulation sont traitées en assimilant les asphaltènes dans l'huile à des particules colloïdales en suspension, susceptibles de se déposer à la surface des pores et ainsi de réduire la perméabilité du milieu poreux. Les premi

  20. SARNET: Severe accident research network of excellence

    International Nuclear Information System (INIS)

    Albiol, T.; Van Dorsselaere, J. P.; Chaumont, B.; Haste, T.; Journeau, Ch.; Meyer, L.; Sehgal, Bal Raj; Schwinges, Bernd; Beraha, D.; Annunziato, A.; Zeyen, R.

    2010-01-01

    Fifty-one organisations network in SARNET (Severe Accident Research Network of Excellence) their research capacities in order to resolve the most important pending issues for enhancing, with regard to Severe Accidents (SA), the safety of existing and future Nuclear Power Plants (NPPs). This project. co-funded by the European Commission (EC) under the 6. Framework Programme, has been defined in order to optimise the use of the available means and to constitute sustainable research groups in the European Union. SARNET tackles the fragmentation that may exist between the different national R and D programmes, in defining common research programmes and developing common computer tools and methodologies for safety assessment. SARNET comprises most of the organisations involved in SA research in Europe, plus Canada. To reach these objectives, all the organisations networked in SARNET contributed to a joint Programme of Activities, which consisted of: Implementation of an advanced communication tool for accessing all project information, fostering exchange of information, and managing documents; Harmonization and re-orientation of the research programmes, and definition of new ones; Analysis of the experimental results provided by research programmes in order to elaborate a common understanding of relevant phenomena; Development of the ASTEC code (integral computer code used to predict the NPP behaviour during a postulated SA), which capitalizes in terms of physical models the knowledge produced within SARNET; Development of Scientific Databases in which all the results of research programmes are stored in a common format (DATANET); Development of a common methodology for Probabilistic Safety Assessment of NPPs; Development of short courses and writing a textbook on Severe Accidents for students and researchers; Promotion of personnel mobility amongst various European organisations. This paper presents the major achievements after four and a half years of operation of the

  1. Contamination potentielle des aliments par des ...

    African Journals Online (AJOL)

    SARA Computers

    la notion de la pollution et de l'exposition aux PCBs, lorsque 77% n'ont pas conscience de cette situation de risque ... 2018). Quoique la contamination par les. PCBs soit de faible niveau, elle est ...... Université Paris-Est, Paris, France ; 183.

  2. Appreciative Management – A Management based on Excellence

    OpenAIRE

    Simona PONEA

    2010-01-01

    Appreciative management support organizations, especially in the process of development of the human resources. Appreciative management considered as a management based on excellence, is based on the filosophy of appreciative inquiry. Any organization can apply this model starting with the process of recruitment. The process of employment requires each time a new beginning for the organization. New employees should be introduced carefully in the organizational culture and also must be provide...

  3. Sales Training for Army Recruiter Success: Interviews with Excellent Recruiters

    Science.gov (United States)

    1987-11-01

    merit of an expert modeling system of the skills and strategies used by excel- lent Army recruiters. Neurolinguistic programming (NLP) was used as the...7. AUTHOR(&) 8. CONTRACT OR GRANT NUMBER(s) Steven R. Frieman 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK U.S...Recruiting 2M AUSTIRACT (rcnttm ame r orw am nssry i Identify by block number) s-This report describes a program of research on communication strategies and

  4. Physiological bases for detecting and predicting photoinhibition of aquatic photosynthesis by PAR and UV radiation

    International Nuclear Information System (INIS)

    Neale, P.J.; Cullen, J.J.; Lesser, M.P.; Melis, A.

    1993-01-01

    stress is usually time dependent (12, 36); the light history of the cells must be known to specify the overall effect. The established method for measuring phytoplankton production, photosynthetic incorporation of 14 C into organic carbon during a12-24 h bottle incubation, may seriously misrepresent irradiance regimes actually experienced by phytoplankton in situ. Further discussion of the interaction of photoinhibition and mixing can be found in (36).We propose that an integrated modeling-sampling approach is needed to define the effects of irradiance stress on productivity in situ. The model should incorporate an optical specification of the underwater irradiance environment, abiological weighting function to account for the wavelength-dependence of photoinhibition of photosynthesis, and a response function of biological action during vertical mixing to account for the differences between static incubations and natural movements of phytoplankton. Recently, excellent progress has been made toward defining the individual components of this model (See also Cullen and Neale, this volume). To verify the model, we need to detect reliably the occurrence of irradiance stress in situ. This is the sampling side of the integrated approach. In particular, we would like to differentiate between the effects of PAR and UV. We propose that such detection can be accomplished by indicator assays (or ''diagnostic markers''). Such assays would involve little or no incubation of samples, so that the measurement corresponds as closely as possible to the physiological state of the phytoplankton at time of sampling.Our objective here is to review selected aspects of irradiance stress at biophysical and molecular levels, and then proceed to examine how that information can be used to design indicator assays of irradiance stress for phytoplankton photosynthesis in situ. The effects of PAR and UV at the cellular level and the use of in vivo fluorescence and molecular probes

  5. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes.......Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...

  6. Mobile-media pragmatism: innovation excellences and encumbrances

    Science.gov (United States)

    Lin, Chen-Ju

    2017-10-01

    Establishing two pragmatic models of enhancing entertainment and job-performance, this study aims to elaborate on how people adopt and perceive innovation excellences and encumbrances of modern mobile-media services through reflecting on their intrinsic expectancy. A survey methodology was executed to examine the hypothesised variable relationships using the purposive sampling method. CHT's Taipei think-tank head-office provided this study with a representative sampling frame and assisted to collect data from 725 focused subjects (with normative characteristics) who subscribed to HiNet or MOD, or predominantly used 4G telecommunication services. As a result of adopting the structural equation modelling test, the models of perceived innovation excellences and innovation encumbrances were affirmatively established to interpret the two applicative scenarios: entertainment and job-performance enhancement. Several valuable findings were generated. When a consumer targets entertainment technology pragmatism, he or she may stress the importance of innovative excellences, especially on product novelty. For the sake of pursuing job-performance enhancement, a customer was actively willing to invest his or her energy to meet and deal with the learning cost, customer unfamiliarity and complexity of telecom products and services. Importantly, the adopter's previous experiences with telecom products in the IT domain could effectively moderate the effect of pursuing new telecom innovation, adopting the product, and then strengthening self-evaluation.

  7. Achieving Business Excellence Prize: The Case Of Trimo Trebnje d.d.

    OpenAIRE

    Metka Tekavcic; Darja Peljhan

    2011-01-01

    The late 1980s and early 1990s saw a global realization of the strategic importance of quality, and many countries established programmes to recognize quality and excellence. Companies pursuing an excellence strategy soon recognized that the award frameworks offered more than just a vehicle for recognition. The frameworks were seen to be best-practice models for implementing excellence strategies, performing self-assessments, benchmarking and, ultimately, delivering improved performance. The ...

  8. Furrow Irrigation Management and Design Criteria Using Efficiency Parameters and Simulation Models Criterios para Manejo y Diseño de Riego por Surcos Utilizando Parámetros de Eficiencia y Modelos de Simulación

    Directory of Open Access Journals (Sweden)

    Eduardo A. Holzapfel

    2010-06-01

    Full Text Available This study analyzes the relationship between the variables of furrow irrigation and the irrigation performance parameters, crop yield, and deep percolation as a basis for furrow irrigation design and management. Application efficiency (AE, requirement efficiency (RE, requirement distribution efficiency (RDE, total distribution efficiency (TDE, and furrow irrigation management, operation, and design variables (inflow discharge, furrow length, and irrigation cutoff time were correlated. The relationship between performance irrigation parameters and relative yield was also examined. In addition, environmental aspects related to leaching and runoff were also presented for each of the parameters. Study results indicate that increasing the length of the furrow reduces RE, RDE, and TDE values. However, an increase in inflow discharge and cutoff time increases efficiency. In contrast, an increase in furrow length increases AE while an increase in inflow discharge and cutoff time reduces it. Unlike AE, RE, RDE, and TDE parameters are well-correlated with relative yield. TDE and AE are recommended parameters for the design, management, and operation of furrow irrigation systems, in order to establish good irrigation practices, and to prevent contamination.El presente artículo analiza la relación entre las variables de riego por surcos y los parámetros que determinan la calidad del riego, producción, y percolación profunda como base para el diseño y manejo del riego por surcos. Se ha realizado la correlación entre la eficiencia de aplicación (AE, eficiencia de requerimiento (RE, eficiencia de distribución del requerimiento (RDE, eficiencia de distribución total (TDE, y las variables de manejo, operación y diseño de riego por surcos (caudal, longitud de surco y tiempo de corte de riego. También se ha examinado la relación entre los parámetros que determinan la calidad de riego y la producción relativa. Además, se presentan para cada uno de

  9. Excellent lubricating behavior of Brasenia schreberi mucilage.

    Science.gov (United States)

    Li, Jinjin; Liu, Yuhong; Luo, Jianbin; Liu, Pengxiao; Zhang, Chenhui

    2012-05-22

    The present work reports an excellent lubrication property of an aquatic plant called Brasenia schreberi (BS). To investigate the lubrication characteristics of the BS mucilage, a novel measuring system is designed, and an ultralow friction coefficient about 0.005 between the mucilage and glass surface has been obtained. It is found that the ultralow friction is closely related to the structure of mucilage and water molecules in the mucilage. The microstructure analysis indicates that the mucilage surrounding BS forms a kind of polysaccharide gel with many nanosheets. A possible lubrication mechanism is proposed that the formation of hydration layers among these polymer nanosheets with plenty of bonded water molecules causes the ultralow friction. The excellent lubrication property has a potential application for reducing the friction between a glossy pill coated with such layer of mucilage and people's throats.

  10. Discussion on 'Centres of excellence' in Africa

    International Nuclear Information System (INIS)

    Riad, S.

    1999-01-01

    In Africa, Centres of Excellence should be oriented to build up scientific and technological capacity in the four topics of international Monitoring System related technologies, namely, seismic monitoring, hydro acoustic monitoring, infrasound monitoring and radionuclides monitoring. Training programs on these topics should be a major objective. A network of such centres should be established in a number of African countries. Centres should be equipped with means and materials for on-line course dispatch to interested training centres or research institutions. African centres should develop strong relationship among themselves through information and data exchange and sharing, harmonization of training programs. National data centres may be established as a component of the African Centre of Excellence. States Signatories may authorize the establishment of a specific fund to support the activities of the African center

  11. Simulink/PARS Integration Support

    Energy Technology Data Exchange (ETDEWEB)

    Vacaliuc, B. [ORNL; Nakhaee, N. [Sundance DSP, Inc.

    2013-12-18

    The state of the art for signal processor hardware has far out-paced the development tools for placing applications on that hardware. In addition, signal processors are available in a variety of architectures, each uniquely capable of handling specific types of signal processing efficiently. With these processors becoming smaller and demanding less power, it has become possible to group multiple processors, a heterogeneous set of processors, into single systems. Different portions of the desired problem set can be assigned to different processor types as appropriate. As software development tools do not keep pace with these processors, especially when multiple processors of different types are used, a method is needed to enable software code portability among multiple processors and multiple types of processors along with their respective software environments. Sundance DSP, Inc. has developed a software toolkit called “PARS”, whose objective is to provide a framework that uses suites of tools provided by different vendors, along with modeling tools and a real time operating system, to build an application that spans different processor types. The software language used to express the behavior of the system is a very high level modeling language, “Simulink”, a MathWorks product. ORNL has used this toolkit to effectively implement several deliverables. This CRADA describes this collaboration between ORNL and Sundance DSP, Inc.

  12. In vitro and in vivo inhibition of proangiogenic retinal phenotype by an antisense oligonucleotide downregulating uPAR expression.

    Science.gov (United States)

    Lulli, Matteo; Cammalleri, Maurizio; Granucci, Irene; Witort, Ewa; Bono, Silvia; Di Gesualdo, Federico; Lupia, Antonella; Loffredo, Rosa; Casini, Giovanni; Dal Monte, Massimo; Capaccioli, Sergio

    2017-08-26

    Neoangiogenesis is the main pathogenic event involved in a variety of retinal diseases. It has been recently demonstrated that inhibiting the urokinase-type plasminogen activator receptor (uPAR) results in reduced angiogenesis in a mouse model of oxygen-induced retinopathy (OIR), establishing uPAR as a therapeutic target in proliferative retinopathies. Here, we evaluated in cultured human retinal endothelial cells (HRECs) and in OIR mice the potential of a specific antisense oligodeoxyribonucleotide (ASO) in blocking the synthesis of uPAR and in providing antiangiogenic effects. uPAR expression in HRECs was inhibited by lipofection with the phosphorotioated 5'-CGGCGGGTGACCCATGTG-3' ASO-uPAR, complementary to the initial translation site of uPAR mRNA. Inhibition of uPAR expression via ASO-uPAR was evaluated in HRECs by analyzing VEGF-induced tube formation and migration. In addition, the well-established and reproducible murine OIR model was used to induce retinal neovascularization in vivo. OIR mice were injected intraperitoneally with ASO-uPAR and retinopathy was evaluated considering the extent of the avascular area in the central retina and neovascular tuft formation. The ASO-uPAR specifically decreased uPAR mRNA and protein levels in HRECs and mitigated VEGF-induced tube formation and cell migration. Noteworthy, in OIR mice ASO-uPAR administration reduced both the avascular area and the formation of neovascular tufts. In conclusion, although the extrapolation of these experimental findings to the clinic is not straightforward, ASO-uPAR may be considered a potential therapeutic tool for treatment of proliferative retinal diseases. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Leadership for Business Excellence: The Gender Perspective

    OpenAIRE

    DREW, EILEEN PATRICIA

    2008-01-01

    PUBLISHED The adoption of appropriate forms of leadership in response to modern organizational needs has become a major strand of management theory and underpins the pursuit of Total Quality/Business Excellence. With some notable exceptions, most of the leadership literature ignores the gender dimension of leadership This gender blindness and the association ofh management and leadership with men is being challenged through feminist/gender studies drawing upon ideas about po...

  14. LICSS - a chemical spreadsheet in microsoft excel.

    Science.gov (United States)

    Lawson, Kevin R; Lawson, Jonty

    2012-02-02

    Representations of chemical datasets in spreadsheet format are important for ready data assimilation and manipulation. In addition to the normal spreadsheet facilities, chemical spreadsheets need to have visualisable chemical structures and data searchable by chemical as well as textual queries. Many such chemical spreadsheet tools are available, some operating in the familiar Microsoft Excel environment. However, within this group, the performance of Excel is often compromised, particularly in terms of the number of compounds which can usefully be stored on a sheet. LICSS is a lightweight chemical spreadsheet within Microsoft Excel for Windows. LICSS stores structures solely as Smiles strings. Chemical operations are carried out by calling Java code modules which use the CDK, JChemPaint and OPSIN libraries to provide cheminformatics functionality. Compounds in sheets or charts may be visualised (individually or en masse), and sheets may be searched by substructure or similarity. All the molecular descriptors available in CDK may be calculated for compounds (in batch or on-the-fly), and various cheminformatic operations such as fingerprint calculation, Sammon mapping, clustering and R group table creation may be carried out.We detail here the features of LICSS and how they are implemented. We also explain the design criteria, particularly in terms of potential corporate use, which led to this particular implementation. LICSS is an Excel-based chemical spreadsheet with a difference:• It can usefully be used on sheets containing hundreds of thousands of compounds; it doesn't compromise the normal performance of Microsoft Excel• It is designed to be installed and run in environments in which users do not have admin privileges; installation involves merely file copying, and sharing of LICSS sheets invokes automatic installation• It is free and extensibleLICSS is open source software and we hope sufficient detail is provided here to enable developers to add their

  15. System Description: Embedding Verification into Microsoft Excel

    OpenAIRE

    Collins, Graham; Dennis, Louise Abigail

    2000-01-01

    The aim of the PROSPER project is to allow the embedding of existing verification technology into applications in such a way that the theorem proving is hidden, or presented to the end user in a natural way. This paper describes a system built to test whether the PROSPER toolkit satisfied this aim. The system combines the toolkit with Microsoft Excel, a popular commercial spreadsheet application.

  16. Professional excellence : defining learning outcomes for honours higher education

    NARCIS (Netherlands)

    Fuller, Melissa; Robbe, Patricia; Wolfensberger, Marca

    2016-01-01

    Purpose Honours programs prepare talented students to become future excellent professionals . However, competences defining an excellent professional have not been elucidated yet. We investigated how professionals characterize an excellent communication professional, aiming to develop a competence

  17. A Physics and Tabulated Chemistry Based Compression Ignition Combustion Model: from Chemistry Limited to Mixing Limited Combustion Modes Un modèle de combustion à allumage par compression basé sur la physique et la chimie tabulée : des modes de combustion contrôlés par la chimie jusqu’aux modes contrôlés par le mélange

    Directory of Open Access Journals (Sweden)

    Bordet N.

    2011-11-01

    Full Text Available This paper presents a new 0D phenomenological approach to predict the combustion process in multi injection Diesel engines operated under a large range of running conditions. The aim of this work is to develop a physical approach in order to improve the prediction of in-cylinder pressure and heat release. Main contributions of this study are the modeling of the premixed part of the Diesel combustion with a further extension of the model for multi-injection strategies. In the present model, the rate of heat release due to the combustion for the premixed phase is related to the mean reaction rate of fuel which is evaluated by an approach based on tabulated local reaction rate of fuel and on the determination of the Probability Density Function (PDF of the mixture fraction (Z, in order to take into consideration the local variations of the fuel-air ratio. The shape of the PDF is presumed as a standardized β-function. Mixture fraction fluctuations are described by using a transport equation for the variance of Z. The standard mixture fraction concept established in the case of diffusion flames is here adapted to premixed combustion to describe inhomogeneity of the fuel-air ratio in the control volume. The detailed chemistry is described using a tabulated database for reaction rates and cool flame ignition delay as a function of the progress variable c. The mixing-controlled combustion model is based on the calculation of a characteristic mixing frequency which is a function of the turbulence density, and on the evolution of the available fuel vapor mass in the control volume. The developed combustion model is one sub-model of a thermodynamic model based on the mathematical formulation of the conventional two-zone approach. In addition, an extended sub-model for multi injection is developed to take into account interactions between each spray by describing their impact on the mixture formation. Numerical results from simulations are compared with

  18. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable inflammatory biomarker. In patients, suPAR is a marker of disease presence, severity and prognosis. In the general population, suPAR is predictive of disease development, such as diabetes and cardiovascular disease a...

  19. Copenhagen uPAR prostate cancer (CuPCa) database

    DEFF Research Database (Denmark)

    Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

    2016-01-01

    AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS...

  20. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

    2015-01-01

    . This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...

  1. Aplicação das inferências clássica e bayesiana na estimação dos parâmetros do modelo de densidade populacional de plantas daninhas Application of classic and bayesian inferences on the estimation of weed population density model parameters

    Directory of Open Access Journals (Sweden)

    L.S. Vismara

    2007-12-01

    Full Text Available A dinâmica da população de plantas daninhas pode ser representada por um sistema de equações que relaciona as densidades de sementes produzidas e de plântulas em áreas de cultivo. Os valores dos parâmetros dos modelos podem ser inferidos diretamente de experimentação e análise estatística ou extraídos da literatura. O presente trabalho teve por objetivo estimar os parâmetros do modelo de densidade populacional de plantas daninhas, a partir de um experimento conduzido na área experimental da Embrapa Milho e Sorgo, Sete Lagoas, MG, via os procedimentos de inferências clássica e Bayesiana.Dynamics of weed populations can be described as a system of equations relating the produced seed and seedling densities in crop areas. The model parameter values can be either directly inferred from experimentation and statistical analysis or obtained from the literature. The objective of this work was to estimate the weed population density model parameters based on experimental field data at Embrapa Milho e Sorgo, Sete Lagoas, MG, using classic and Bayesian inferences.

  2. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  3. A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)

    DEFF Research Database (Denmark)

    Mertens, Haydyn D.T.; Kjærgaard, Magnus; Mysling, Simon

    2012-01-01

    -deuterium exchange, and surface plasmon resonance to develop a structural model describing the allosteric regulation of uPAR. We show that the flexibility of its N-terminal domain provides the key for understanding this allosteric mechanism. Importantly, our model has direct implications for understanding uPAR-assisted...... cell adhesion and migration as well as for translational research including targeted intervention therapy and non-invasive tumor imaging in vivo....

  4. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

    Science.gov (United States)

    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  5. Interest of a treatment combined by radioimmunotherapy and Avastin 1 in a murine model of thyroid medullary carcinoma; Interet d'un traitement combine par radioimmunotherapie et Avastin1 dans un modele murin de carcinome medullaire de la thyroide

    Energy Technology Data Exchange (ETDEWEB)

    Salaun, P.Y.; Bodet-Milin, C.; Paris, F.; Frampas, E.; Sai Maurel, C.; Faivre Chauvet, A.; Barbet, J.; Kraeber Bodere, F. [Unite Inserm U892, Brest, (France)

    2009-05-15

    The objective of this study was to evaluate the efficiency and the toxicity of the association radioimmunotherapy and bevacizumab on a murine model grafted by the human line T.T. of thyroid medullar cancer. After results it appears that in pretreatment, bevacizumab (Avastin) improves the efficiency of radioimmunotherapy without increasing the toxicity face the radioimmunotherapy alone. (N.C.)

  6. Access to the kinematic information for the velocity model determination by 3-D reflexion tomography; Acces a l'information cinematique pour la determination du modele de vitesse par tomographie de reflexion 3D

    Energy Technology Data Exchange (ETDEWEB)

    Broto, K.

    1999-04-01

    The access to a reliable image of the subsurface requires a kinematically correct velocity depth model.Reflection tomography allows to meet this requirement if a complete and coherent pre-stack kinematic database can be provided. However, in case of complex sub-surfaces, wave propagation may lead to hardly interpretable seismic events in the time data. The SMART method is a sequential method that relies on reflection tomography for updating the velocity model and on the pre-stack depth migrated domain for extracting kinematic information that is not readily accessible in the time domain. For determining 3-D subsurface velocity models in case of complex structures, we propose the seriated SMART 2-D method as an alternative to the currently inconceivable SMART 3-D method. In order to extract kinematic information from a 3-D pre-stack data set, we combine detours through the 2-D pre-stack depth domain for a number of selected lines of the studied 3-D survey and 3-D reflection tomography for updating the velocity model. The travel-times from the SMART method being independent of the velocity model used for passing through the pre-stack depth migrated domain, the access to 3-D travel-times is ensured, even if they have been obtained via a 2-D domain. Besides, we propose to build a kinematical guide for ensuring the coherency of the seriated 2-D pre-stack depth interpretations and the access to a complete 3-D pre-stack kinematic database when dealing with structures associated with 3-D wave propagation. We opt for a blocky representation of the velocity model in order to be able to cope with complex structures. This representation leads us to define specific methodological rules for carrying out the different steps of the seriated SMART 2-D method. We also define strategies, built from the analysis of first inversion results, for an efficient application of reflection tomography. Besides, we discuss the problem of uncertainties to be assigned to travel-times obtained

  7. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Science.gov (United States)

    Baronian, Grégory; Ginda, Katarzyna; Berry, Laurence; Cohen-Gonsaud, Martin; Zakrzewska-Czerwińska, Jolanta; Jakimowicz, Dagmara; Molle, Virginie

    2015-01-01

    Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  8. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Directory of Open Access Journals (Sweden)

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  9. Determination of anisotropic velocity model by reflection tomography of compression and shear modes; Determination de modele de vitesse anisotrope par tomographie de reflexion des modes de compression et de cisaillement

    Energy Technology Data Exchange (ETDEWEB)

    Stopin, A.

    2001-12-01

    As the jump from 2D to 3D, seismic exploration lives a new revolution with the use of converted PS waves. Indeed PS converted waves are proving their potential as a tool for imaging through gas; lithology discrimination; structural confirmation; and more. Nevertheless, processing converted shear data and in particular determining accurate P and S velocity models for depth imaging of these data is still a challenging problem, especially when the subsurface is anisotropic. To solve this velocity model determination problem we propose to use reflection travel time tomography. In a first step, we derive a new approximation of the exact phase velocity equation of the SV wave in anisotropic (TI) media. This new approximation is valid for non-weak anisotropy and is mathematically simpler to handle than the exact equation. Then, starting from an isotropic reflection tomography tool developed at Lt-'P, we extend the isotropic bending ray tracing method to the anisotropic case and we implement the quantities necessary for the determination of the anisotropy parameters from the travel time data. Using synthetic data we then study the influence of the different anisotropy parameters on the travel times. From this analysis we propose a methodology to determine a complete anisotropic subsurface model (P and S layer velocities, interface geometries, anisotropy parameters). Finally, on a real data set from the Gulf of Mexico we demonstrate that this new anisotropic reflection tomography tool allows us to obtain a reliable subsurface model yielding kinematically correct and mutually coherent PP and PS images in depth; such a result could not be obtained with an isotropic velocity model. Similar results are obtained on a North Sea data set. (author)

  10. Determination of anisotropic velocity model by reflection tomography of compression and shear modes; Determination de modele de vitesse anisotrope par tomographie de reflexion des modes de compression et de cisaillement

    Energy Technology Data Exchange (ETDEWEB)

    Stopin, A

    2001-12-01

    As the jump from 2D to 3D, seismic exploration lives a new revolution with the use of converted PS waves. Indeed PS converted waves are proving their potential as a tool for imaging through gas; lithology discrimination; structural confirmation; and more. Nevertheless, processing converted shear data and in particular determining accurate P and S velocity models for depth imaging of these data is still a challenging problem, especially when the subsurface is anisotropic. To solve this velocity model determination problem we propose to use reflection travel time tomography. In a first step, we derive a new approximation of the exact phase velocity equation of the SV wave in anisotropic (TI) media. This new approximation is valid for non-weak anisotropy and is mathematically simpler to handle than the exact equation. Then, starting from an isotropic reflection tomography tool developed at Lt-'P, we extend the isotropic bending ray tracing method to the anisotropic case and we implement the quantities necessary for the determination of the anisotropy parameters from the travel time data. Using synthetic data we then study the influence of the different anisotropy parameters on the travel times. From this analysis we propose a methodology to determine a complete anisotropic subsurface model (P and S layer velocities, interface geometries, anisotropy parameters). Finally, on a real data set from the Gulf of Mexico we demonstrate that this new anisotropic reflection tomography tool allows us to obtain a reliable subsurface model yielding kinematically correct and mutually coherent PP and PS images in depth; such a result could not be obtained with an isotropic velocity model. Similar results are obtained on a North Sea data set. (author)

  11. [Ambroise Paré in French literature].

    Science.gov (United States)

    Dumaitre, P

    1995-01-01

    The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.

  12. The Prevalence of Service Excellence and the Use of Business Process Improvement Methodologies in Australian Universities

    Science.gov (United States)

    Ciancio, Sharone

    2018-01-01

    Service transformation is an increasingly common pursuit in the higher education sector, with university strategic plans frequently featuring a "service excellence" objective and the adoption of leaner and more sustainable service models. Previous studies agree that service excellence is intentional not incidental, and systematic not…

  13. Redesigning Schools to Reach Every Student with Excellent Teachers: Financial Planning Summary

    Science.gov (United States)

    Public Impact, 2012

    2012-01-01

    This brief summarizes the ways that schools and their teachers can simultaneously reach more students with excellent teaching, expand teachers' career opportunities, and sustainably fund higher pay and other priorities. This is based on Public Impact's school models that use job redesign and technology to extend the reach of excellent teachers to…

  14. Par Pond refill water quality sampling

    International Nuclear Information System (INIS)

    Koch, J.W. II; Martin, F.D.; Westbury, H.M.

    1996-08-01

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column

  15. Development of a 3-D model for eddy current testing: application for fastened structures in aeronautics; Developpement d'un modele pour le controle non destructif par courants de Foucault de structures rivetees en aeronautique

    Energy Technology Data Exchange (ETDEWEB)

    Paillard, S

    2007-12-15

    One of the Eddy Current Testing issues in aeronautics is the inspection of fastened structures to detect flaws nearby rivets which can grow because of mechanical stress. EADS and the CEA LIST have started a collaborative work with the support of the Ile-de-France Region to develop a simulation tool of EC fastened structures testing, integrated to the CIVA platform, aimed at conceiving testing methods, optimizing and qualifying it. The volume integral method using the Green dyadics formalism has been chosen in order to get a fast resolution of Maxwell equations. A first milestone was to build a simulation model of multilayer structures testing, thanks to the use of the multilayer Green dyads. Because of the rivet volume, 60 times bigger than the one of a typical flaw, a large number of discretization cells are needed. Therefore an iterative method has been developed in order to numerically solve large calculation zones. Finally, the flaw response simulation mostly has to cope with a scale issue between the size of the rivet and the one of the flaw, the latter being much smaller in a direction than the former. The whole model has been experimentally validated and compared to other simulation models at the important development steps: multilayer configuration, iteration resolution, and flaw signature. (author)

  16. Tutorial: simulating chromatography with Microsoft Excel Macros.

    Science.gov (United States)

    Kadjo, Akinde; Dasgupta, Purnendu K

    2013-04-22

    Chromatography is one of the cornerstones of modern analytical chemistry; developing an instinctive feeling for how chromatography works will be invaluable to future generation of chromatographers. Specialized software programs exist that handle and manipulate chromatographic data; there are also some that simulate chromatograms. However, the algorithm details of such software are not transparent to a beginner. In contrast, how spreadsheet tools like Microsoft Excel™ work is well understood and the software is nearly universally available. We show that the simple repetition of an equilibration process at each plate (a spreadsheet row) followed by discrete movement of the mobile phase down by a row, easily automated by a subroutine (a "Macro" in Excel), readily simulates chromatography. The process is readily understood by a novice. Not only does this permit simulation of isocratic and simple single step gradient elution, linear or multistep gradients are also easily simulated. The versatility of a transparent and easily understandable computational platform further enables the simulation of complex but commonly encountered chromatographic scenarios such as the effects of nonlinear isotherms, active sites, column overloading, on-column analyte degradation, etc. These are not as easily simulated by available software. Views of the separation as it develops on the column and as it is seen by an end-column detector are both available in real time. Excel 2010™ also permits a 16-level (4-bit) color gradation of numerical values in a column/row; this permits visualization of a band migrating down the column, much as Tswett may have originally observed, but in a numerical domain. All parameters of relevance (partition constants, elution conditions, etc.) are readily changed so their effects can be examined. Illustrative Excel spreadsheets are given in the Supporting Information; these are easily modified by the user or the user can write his/her own routine. Copyright

  17. Pursuit of excellence: A forgotten quest?

    Directory of Open Access Journals (Sweden)

    Mark B Wertheimer

    2018-01-01

    Full Text Available The article explores the current orthodontic landscape with respect to the challenges that affect the pursuit of excellence in the specialty. These challenges include marketing by manufacturing companies, financial pressures, marketplace competition, attaining practice efficiency, new product introduction with limited supporting evidence, attributing greater importance to patient experience than the best approach to treatment, and lack of public education regarding their best interests. Home or DIY treatment, bypassing office visits and the practitioner, have also emerged as a concerning trend with the public not clearly understanding the detrimental consequences that may ensue. An over reliance on technology may override individualized treatment and further compromise treatment results.

  18. The behaviour of hydrogen in Excel alloy

    Energy Technology Data Exchange (ETDEWEB)

    Ells, C.E. [Atomic Energy of Canada Ltd., Chalk River, ON (Canada). Chalk River Nuclear Labs.; Coleman, C.E. [Atomic Energy of Canada Ltd., Chalk River, ON (Canada). Chalk River Nuclear Labs.; Cheadle, B.A. [Atomic Energy of Canada Ltd., Chalk River, ON (Canada). Chalk River Nuclear Labs.; Sagat, S. [Atomic Energy of Canada Ltd., Chalk River, ON (Canada). Chalk River Nuclear Labs.; Rodgers, D.K. [Atomic Energy of Canada Ltd., Chalk River, ON (Canada). Chalk River Nuclear Labs.

    1995-12-15

    To enable mitigation of deleterious effects from hydride on the mechanical behaviour of Excel alloy, Zr-3.5 wt.% Sn-0.8 wt.% Mo-0.8 wt.% Nb, the behaviours of hydrogen and hydride in the alloy have been studied. Properties of interest are the terminal solid solubility, diffusivity, heat of transport, stress reorientation, and the initiation and crack growth of delayed hydride cracking. The results obtained are compared with those of other zirconium-rich alloys, notably Zr-2.5 wt.% Nb. (orig.)

  19. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly......, hence identifying the N terminus of ParB as a requirement for ParB-mediated centromere pairing. These observations suggest that centromere pairing is an important intermediate step in plasmid partitioning mediated by the common type I loci....

  20. New peptide receptor radionuclide therapy of invasive cancer cells: in vivo studies using 177Lu-DOTA-AE105 targeting uPAR in human colorectal cancer xenografts

    DEFF Research Database (Denmark)

    Persson, Morten; Rasmussen, Palle; Madsen, Jacob

    2012-01-01

    -of-concept for a theranostic approach as treatment modality in a human xenograft colorectal cancer model. MethodsA DOTA-conjugated 9-mer high affinity uPAR binding peptide (DOTA-AE105) was radiolabeled with 64Cu and 177Lu, for PET imaging and targeted radionuclide therapy study, respectively. Human uPAR-positive CRC HT-29...... for the first time the in vivo efficacy of an uPAR-targeted radionuclide therapeutic intervention on both tumor size and its content of uPAR expressing cells thus setting the stage for future translation into clinical use. © 2012 Elsevier Inc. All rights reserved....

  1. Self-scheduling with Microsoft Excel.

    Science.gov (United States)

    Irvin, S A; Brown, H N

    1999-01-01

    Excessive time was being spent by the emergency department (ED) staff, head nurse, and unit secretary on a complex 6-week manual self-scheduling system. This issue, plus inevitable errors and staff dissatisfaction, resulted in a manager-lead initiative to automate elements of the scheduling process using Microsoft Excel. The implementation of this initiative included: common coding of all 8-hour and 12-hour shifts, with each 4-hour period represented by a cell; the creation of a 6-week master schedule using the "count-if" function of Excel based on current staffing guidelines; staff time-off requests then entered by the department secretary; the head nurse, with staff input, then fine-tuned the schedule to provide even unit coverage. Outcomes of these changes included an increase in staff satisfaction, time saved by the head nurse, and staff work time saved because there was less arguing about the schedule. Ultimately, the automated self-scheduling method was expanded to the entire 700-bed hospital.

  2. Le choix de l'excellence

    CERN Document Server

    Collins, Jim

    2012-01-01

    Dix ans après le succès mondial de De la performance à l'excellence (Good to Great), Jim Collins et son associé Morten T. Hansen s'interrogent ici sur la nature de l excellence en période d incertitude. Pourquoi, dans un contexte chaotique, certaines entreprises sont florissantes et d autres non ? Comment, en ces temps troublés, réussir à diriger et vaincre l adversité pour dominer son marché ? La chance peut-elle sérieusement être envisagée comme un facteur de réussite ? À l issue d un programme de recherche ambitieux et rigoureux qui a duré neuf ans, les auteurs exposent dans cet ouvrage les nouveaux principes pour bâtir une entreprise réellement excellente. Leurs conclusions sont, comme toujours, étonnantes. Ils soulignent notamment que la course à l innovation n est pas toujours la meilleure voie à suivre, que discipline et créativité peuvent aller de concert et que malgré le changement permanent, les meilleures décisions sont rarement prises dans l urgence. Quant aux leaders, on...

  3. Discrimination against Women as a Subtext of Excellence.

    Science.gov (United States)

    Watson, Scott B.

    1993-01-01

    Pursuing excellence in sport discriminates against women. Alongside the primary texts of the glories of excellence runs a subtext of inequality and discrimination. The paper traces the idea of sport as a quest for excellence through various interpretations of the meaning of sport, discussing excellence as a socially constructed concept. (SM)

  4. uPAR Targeted Radionuclide Therapy with 177Lu-DOTA-AE105 Inhibits Dissemination of Metastatic Prostate Cancer

    DEFF Research Database (Denmark)

    Persson, Morten; Juhl, Karina; Rasmussen, Palle

    2014-01-01

    The urokinase-type plasminogen activator receptor (uPAR) is implicated in cancer invasion and metastatic development in prostate cancer and provides therefore an attractive molecular target for both imaging and therapy. In this study, we provide the first in vivo data on an antimetastatic effect...... of uPAR radionuclide targeted therapy in such lesions and show the potential of uPAR positron emission tomography (PET) imaging for identifying small foci of metastatic cells in a mouse model of disseminating human prostate cancer. Two radiolabeled ligands were generated in high purity and specific...... value of 100 nM in a competitive binding experiment. In vivo, uPAR targeted radionuclide therapy significantly reduced the number of metastatic lesions in the disseminated metastatic prostate cancer model, when compared to vehicle and nontargeted 177Lu groups (p

  5. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.

  6. Model of the containment building of Almaraz NPP and the system of recombiners PARs, with the GOTHIC code, for the study of the diffusion of combustible gases; Modelo del edificio de contencion de C.N. Almaraz y del sistema de recombinadores PARs, con el codigo GOTHIC, para el estudio de la difusion de gases combustibles

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Gonzalez, M.; Huelamo, E.; Mazrtinez, M.; Perez, J. R.

    2014-07-01

    This paper presents the analysis of distribution of gases within the containment building carried out a simulation model with the code Thermo hydraulic GOTHIC, which has been evaluated based on passive autocatalytic recombiners gas control system. The model considers scenarios of severe accident with specific conditions that produce the most hydrogen generation rates. Intended to verify the effectiveness of the control system of gas expected to be installed in the Almaraz Nuclear power plant so that the number and location of recombiners equipment meets its function of preventing the formation of explosive atmospheres which impairs the integrity of the containment, reducing and limiting the concentration of combustible gases during the postulated accident. (Author)

  7. A national neurological excellence centers network.

    Science.gov (United States)

    Pazzi, S; Cristiani, P; Cavallini, A

    1998-02-01

    The most relevant problems related to the management of neurological disorders are (i) the frequent hospitalization in nonspecialist departments, with the need for neurological consultation, and (ii) the frequent requests of GPs for highly specialized investigations that are very expensive and of little value in arriving at a correct diagnosis. In 1996, the Consorzio di Bioingegneria e Informatica Medica in Italy realized the CISNet project (in collaboration with the Consorzio Istituti Scientifici Neuroscienze e Tecnologie Biomediche and funded by the Centro Studi of the National Public Health Council) for the implementation of a national neurological excellence centers network (CISNet). In the CISNet project, neurologists will be able to give on-line interactive consultation and off-line consulting services identifying correct diagnostic/therapeutic procedures, evaluating the need for both examination in specialist centers and admission to specialized centers, and identifying the most appropriate ones.

  8. Guaranteeing CERN’s excellence: consolidate experience

    CERN Multimedia

    Staff Association

    2014-01-01

    For its missions CERN requires staff with solid experience in all its domains of activity The Organization has several missions: fundamental research, technical developments and innovation, training the several hundreds of associates, fellows and students, while at the same time taking care of more than 10000 users. In order to guarantee excellence in all of these areas, CERN has to put in place an efficient personnel policy. Such a policy must allow the Organization to recruit collaborators with the highest competence from all Member States, and to keep and motivate them during their entire professional career. But, more importantly, the Organization has to be able to count on a stable workforce. It needs staff with experience gained over a long period in the fields of accelerators, detectors, and operating procedures, if it is to fulfil successfully its important mission of training and knowledge transfer, which is very much appreciated by our Member states, since it highlights a visible return on invest...

  9. BREEAM Excellent: Business Value Vs Employee Morale

    Science.gov (United States)

    Turner, Nova; Arif, Mohammed

    2012-05-01

    BREEAM is gaining popularity in the UK. Similar green building standards have gained popularity worldwide. However, it is important that we analyse the actual value added to a business by having a BREEAM rated facility. It is also important to analyze the impact on employee performance of such a facility. This paper presents a case study of a BREEAM excellent rated building with impact on the morale and performance of the employees. The data for the paper was collected using semi-structured interviews of a group of employees who work at this facility located in Glasgow. The results suggest that it is important to highlight the tangible benefits and value added through the implementation of the BREEAM standard.

  10. Achieving excellence on shift through teamwork

    International Nuclear Information System (INIS)

    Newman, L.

    1988-01-01

    Anyone familiar with the nuclear industry realizes the importance of operators. Operators can achieve error-free plant operations, i.e., excellence on shift through teamwork. As a shift supervisor (senior reactor operator/shift technical advisor) the author went through the plant's first cycle of operations with no scrams and no equipment damaged by operator error, having since changed roles (and companies) to one of assessing plant operations. This change has provided the opportunity to see objectively the importance of operators working together and of the team building and teamwork that contribute to the shift's success. This paper uses examples to show the effectiveness of working together and outlines steps for building a group of operators into a team

  11. Aluminum alloy excellent in neutron absorbing performance

    International Nuclear Information System (INIS)

    Iida, Tetsuya; Tamamura, Tadao; Morimoto, Hiroyuki; Ouchi, Ken-ichiro.

    1987-01-01

    Purpose: To obtain structural materials made of aluminum alloys having favorable neutron absorbing performance and excellent in the performance as structural materials such as processability and strength. Constitution: Powder of Gd 2 O 3 as a gadolinium compound or metal gadolinium is uniformly mixed with the powder of aluminum or aluminum alloy. The amount of the gadolinium compound added is set to 0.1 - 30 % by weight. No sufficient neutron absorbing performance can be obtained if it is less than 0.1 % by weight, whereas the processability and mechanical property of the alloy are degraded if it exceeds 30 % by weight. Further, the grain size is set to less about 50 μm. Further, since the neutron absorbing performance varies greatly if the aluminum powder size exceeds 100 μm, the diameter is set to less than about 100 μm. These mixtures are molded in a hot press. This enables to obtain aimed structural materials. (Takahashi, M.)

  12. Excel spreadsheet in teaching numerical methods

    Science.gov (United States)

    Djamila, Harimi

    2017-09-01

    One of the important objectives in teaching numerical methods for undergraduates’ students is to bring into the comprehension of numerical methods algorithms. Although, manual calculation is important in understanding the procedure, it is time consuming and prone to error. This is specifically the case when considering the iteration procedure used in many numerical methods. Currently, many commercial programs are useful in teaching numerical methods such as Matlab, Maple, and Mathematica. These are usually not user-friendly by the uninitiated. Excel spreadsheet offers an initial level of programming, which it can be used either in or off campus. The students will not be distracted with writing codes. It must be emphasized that general commercial software is required to be introduced later to more elaborated questions. This article aims to report on a teaching numerical methods strategy for undergraduates engineering programs. It is directed to students, lecturers and researchers in engineering field.

  13. Evaluation of Passive Autocatalytic Recombiner (PAR) Implementation in a Konvoi NPP Containment Type

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Alonso, E.; Papini, D.; Jimenez, G.

    2015-07-01

    The evaluation of Passive Autocatalytic Recombiner (PAR) implementation has been developed under the methodology extracted from the IAEA document, analysing the size, location and number of the PARs capable to minimize the combustion risk, which arises from a hydrogen release generated during a severe accident and its distribution in containment building. A detailed three-dimensional model of Konvoi (PWR) containment with GOTHIC 8.1 code was used for the simulations. The hydrogen preferential pathways and the accumulation points were studied and identified on the basis of a base case scenario without any mitigation measure. The PAR configuration offers an improvement in the chosen accidental scenario; decreasing the possibility of hydrogen combustion and leading to concentration values below the flammability limit (hydrogen concentration below 7%), in all the containment compartments at the end of the transient. Furthermore, from the analysis, it is concluded that the time required to reach hydrogen concentrations below the combustion limit is considerably reduced. (Author)

  14. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L

    2013-01-01

    BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects...... of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI......) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis....

  15. Effect of a physical activity intervention on suPAR levels

    DEFF Research Database (Denmark)

    Rohde, Christopher; Polcwiartek, Christoffer; Andersen, Eivind

    2018-01-01

    OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS......: suPAR and C-reactive protein (CRP) levels were determined in blood samples from a previous randomized controlled trial with Pakistani immigrants in Norway, 2008. The study included physically inactive men that were randomized to an intervention group (supervised group exercises) or a control group...... and followed for 5 months. A linear regression model was used and adjusted for age, inactivity level at baseline, and mean difference in CRP levels. RESULTS: Overall, 80 and 53 participants were included in the intervention and control group, respectively. Obesity and smoking were associated with higher su...

  16. The European network of excellence Emil

    International Nuclear Information System (INIS)

    2006-01-01

    The network of excellence EMIL (European Molecular Imaging Laboratories ) is the only European network of excellence in molecular imaging for oncology. It was set up and is coordinated by the 'in vivo imaging of gene expression' group of CEA Orsay. Included in Priority Thematic Area 1 (life sciences, genomics and biotechnology for health) of the European Commission's 6. Framework Programme for Research and Technological Development (FP6), this five-year project (2004-2009) aims t o merge the leading European research teams in molecular imaging, in universities, research centres and small and medium enterprises, to focus on early diagnosis, prognosis and therapeutic evaluation of cancer. The EMIL network brings together 58 partners representing 43 bodies in 13 European countries, and integrates 6 technological facilities: Orsay (France), Turin (Italy), Cologne (Germany), Leiden (Netherlands), Milan (Italy) and Antwerpen (Belgium).The research and training activities of the EMIL network are based on 9 thematic working groups or 'work packages' (wp), forming a common activity programme including : Integration activities: creation of a network of technological and training facilities favouring the mobility of researchers and the integration of small and medium enterprises into the EMIL network. Dissemination of expertise activities: training, communication, common knowledge management and intellectual property rights. Research activities: a common research programme with a horizontal dimension, making use of methodological tools of physics, biology and chemistry necessary for the further development of molecular imaging (instrument techniques, molecular probes, biological engineering), and a vertical integrative dimension, bringing together cancer imaging applications (early diagnostic imaging, development of new therapies imaging for drug development). (author)

  17. The European network of excellence Emil

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The network of excellence EMIL (European Molecular Imaging Laboratories ) is the only European network of excellence in molecular imaging for oncology. It was set up and is coordinated by the 'in vivo imaging of gene expression' group of CEA Orsay. Included in Priority Thematic Area 1 (life sciences, genomics and biotechnology for health) of the European Commission's 6. Framework Programme for Research and Technological Development (FP6), this five-year project (2004-2009) aims t o merge the leading European research teams in molecular imaging, in universities, research centres and small and medium enterprises, to focus on early diagnosis, prognosis and therapeutic evaluation of cancer. The EMIL network brings together 58 partners representing 43 bodies in 13 European countries, and integrates 6 technological facilities: Orsay (France), Turin (Italy), Cologne (Germany), Leiden (Netherlands), Milan (Italy) and Antwerpen (Belgium).The research and training activities of the EMIL network are based on 9 thematic working groups or 'work packages' (wp), forming a common activity programme including : Integration activities: creation of a network of technological and training facilities favouring the mobility of researchers and the integration of small and medium enterprises into the EMIL network. Dissemination of expertise activities: training, communication, common knowledge management and intellectual property rights. Research activities: a common research programme with a horizontal dimension, making use of methodological tools of physics, biology and chemistry necessary for the further development of molecular imaging (instrument techniques, molecular probes, biological engineering), and a vertical integrative dimension, bringing together cancer imaging applications (early diagnostic imaging, development of new therapies imaging for drug development). (author)

  18. Integrated management system laying a foundation for excellence

    Energy Technology Data Exchange (ETDEWEB)

    Brissette, S.; Vincent, D. [Bruce Power, Tiverton, Ontario (Canada)], E-mail: Derek.VINCENT@brucepower.com

    2009-07-01

    Integration in its simplest form involves seamless coordination between organizational elements such as organization structure, processes, systems and documents. This paper discusses the concept of integration in regards to managed systems and examines practical issues of marrying evolving standards to organizational design and overall governance. Bruce Power's experience in developing its Management System into a more integrated approach is described. Leadership sponsorship of an integrated programmatic approach using a Governance, Oversight, Support and Perform (GOSP) model of accountability framework within the Management System has been a critical success factor in Bruce Power's journey towards achieving operational excellence. (author)

  19. Integrated management system laying a foundation for excellence

    International Nuclear Information System (INIS)

    Brissette, S.; Vincent, D.

    2009-01-01

    Integration in its simplest form involves seamless coordination between organizational elements such as organization structure, processes, systems and documents. This paper discusses the concept of integration in regards to managed systems and examines practical issues of marrying evolving standards to organizational design and overall governance. Bruce Power's experience in developing its Management System into a more integrated approach is described. Leadership sponsorship of an integrated programmatic approach using a Governance, Oversight, Support and Perform (GOSP) model of accountability framework within the Management System has been a critical success factor in Bruce Power's journey towards achieving operational excellence. (author)

  20. Identification of C-terminal hydrophobic residues important for dimerization and all known functions of ParB of Pseudomonas aeruginosa.

    NARCIS (Netherlands)

    Mierzejewska, J.; Bartosik, A.A.; Macioszek, M.; Plochocka, D.; Thomas, C.M.G.; Jagura-Burdzy, G.

    2012-01-01

    The ParB protein of Pseudomonas aeruginosa is important for growth, cell division, nucleoid segregation and different types of motility. To further understand its function we have demonstrated a vital role of the hydrophobic residues in the C terminus of ParB(P.a.). By in silico modelling of the

  1. The paranoia of promotors and the guilt of victims in the praxis of excel-lence in universities: towards a renewal of the desire to teach

    Directory of Open Access Journals (Sweden)

    José Manuel Rodríguez Victoriano

    2017-06-01

    Full Text Available The University of Valencia was the only university in Spain which had not approved the Docentia programme until 2015. This program appeared in 2006, on the stage of the integration of the Spanish Higher Education System within the European Higher Education Area (EHEA. The National Agency for Quality Assessment and Accreditation of Spain (ANECA proposed/imposed a new program sought to control and manage, in business terms, teaching (Dardot & Laval; 2013 to the whole of the Spanish public universities, in entrepreneurial terms the teaching activity. This work situates the program in the process of commodification of the Spanish public university where coexist on par excellence carrot and stick of precarious work and teaching, the paranoia of the excellence and the guilt of their victims. The example of the University of Valencia is used to show Union alternatives and educational responses. Then it is argued that the recovery of the public University, understood as a ’common good’, as well as teaching desire (Hill, 2015 passes through reactivates University ideological response and resistance movements.

  2. Childhood Pars Planitis; Clinical Features and Outcomes

    Directory of Open Access Journals (Sweden)

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  3. Analysis of Knowledge Management Effectiveness on Business Excellence Using System Dynamics

    Directory of Open Access Journals (Sweden)

    mohammad dehghani saryazdi

    2014-05-01

    Full Text Available It can be claimed that an organization is approaching excellence when it achieves acceptable results besides providing appropriate infrastructures and following right processes. Excellence models, such as European Foundation of Quality Management (EFQM, try to establish a tradeoff between enablers and outcomes in evaluating organizational performance. One of those enablers is Knowledge Management (KM, which is gaining increasing attentions nowadays regarding the soaring significance of knowledge resources. In order to evaluate the KM processes, a comprehensive model is required, which should be able to capture all aspects of KM. One of such models is Knowledge Management Assessment Tool (KMAT. This research is an effort to find the relationship between knowledge and business excellence through system dynamics tool. In other words, this research exploits system dynamics in order to measure the effects of KM on business excellence using a dynamic model based upon a combination of KMAT and EFQM.

  4. Determining fPAR and leaf area index of several land cover classes ...

    African Journals Online (AJOL)

    ... fraction of photosynthetically active radiation (fPAR), are three fundamental biophysical characteristics of the plant canopy that should parameterise ecophysiological models of water use (evapotranspiration) and carbon sequestration. Although Earth observation provides values and time series for both these parameters, ...

  5. Model selection in periodic autoregressions

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

    1994-01-01

    textabstractThis paper focuses on the issue of period autoagressive time series models (PAR) selection in practice. One aspect of model selection is the choice for the appropriate PAR order. This can be of interest for the valuation of economic models. Further, the appropriate PAR order is important

  6. The Use of Operational Excellence Principles in a University Hospital.

    Science.gov (United States)

    Edelman, Eric R; Hamaekers, Ankie E W; Buhre, Wolfgang F; van Merode, Godefridus G

    2017-01-01

    The introduction of Operational Excellence in the Maastricht University Medical Center (MUMC+) has been the first of its kind and scale for a university hospital. The policy makers of the MUMC+ have combined different elements from various other business, management, and healthcare philosophies and frameworks into a unique mix. This paper summarizes the journey of developing this system and its most important aspects. Special attention is paid to the role of the operating rooms and the improvements that have taken place there, because of their central role in the working of the hospital. The MUMC+ is the leading tertiary healthcare center for the South-East region of The Netherlands and beyond. Regional, national, and international developments encouraged the MUMC+ to start significantly reorganizing its care processes from 2009 onward. First experiments with Lean Six Sigma and Business Modeling were combined with lessons learned from other centers around the world to form the MUMC+'s own type of Operational Excellence. At the time of writing, many improvement projects of different types have been successfully completed. Every single department in the hospital now uses Operational Excellence and design thinking in general as a method to develop new models of care. An evaluation in 2014 revealed several opportunities for improvement. A large number of projects were in progress, but 75% of all projects had not been completed, despite the first projects being initiated back in 2012. This led to a number of policy changes, mainly focusing on more intensive monitoring of projects and trying to do more improvement projects directly under the responsibility of the line manager. Focusing on patient value, continuous improvement, and the reduction of waste have proven to be very fitting principles for healthcare in general and specifically for application in a university hospital. Approaching improvement at a systems level while directly involving the people on the work

  7. The Use of Operational Excellence Principles in a University Hospital

    Directory of Open Access Journals (Sweden)

    Eric R. Edelman

    2017-07-01

    Full Text Available The introduction of Operational Excellence in the Maastricht University Medical Center (MUMC+ has been the first of its kind and scale for a university hospital. The policy makers of the MUMC+ have combined different elements from various other business, management, and healthcare philosophies and frameworks into a unique mix. This paper summarizes the journey of developing this system and its most important aspects. Special attention is paid to the role of the operating rooms and the improvements that have taken place there, because of their central role in the working of the hospital. The MUMC+ is the leading tertiary healthcare center for the South-East region of The Netherlands and beyond. Regional, national, and international developments encouraged the MUMC+ to start significantly reorganizing its care processes from 2009 onward. First experiments with Lean Six Sigma and Business Modeling were combined with lessons learned from other centers around the world to form the MUMC+’s own type of Operational Excellence. At the time of writing, many improvement projects of different types have been successfully completed. Every single department in the hospital now uses Operational Excellence and design thinking in general as a method to develop new models of care. An evaluation in 2014 revealed several opportunities for improvement. A large number of projects were in progress, but 75% of all projects had not been completed, despite the first projects being initiated back in 2012. This led to a number of policy changes, mainly focusing on more intensive monitoring of projects and trying to do more improvement projects directly under the responsibility of the line manager. Focusing on patient value, continuous improvement, and the reduction of waste have proven to be very fitting principles for healthcare in general and specifically for application in a university hospital. Approaching improvement at a systems level while directly involving the

  8. Excel 2010 all-in-one for dummies

    CERN Document Server

    Harvey, Greg

    2010-01-01

    A comprehensive, up-to-date, user-friendly guide to Excel 2010 Excel is the standard for spreadsheet applications and is used worldwide, but it's not always user-friendly. That makes it a perfect For Dummies topic, and this handy all-in-one guide covers all the essentials, the new features, how to analyze data with Excel, and much more. Eight minibooks address Excel basics, worksheet design, formulas and functions, worksheet collaboration and review, charts and graphics, data management, data analysis, and Excel and VBA.Excel is the leading spreadsheet/data analysis s

  9. Accouchement par forceps: indications et pronostic materno-foetal ...

    African Journals Online (AJOL)

    L'accouchement par voie basse, peut être parfois compromis par des facteurs maternels, foetaux ou materno-foetaux nécessitant des moyens thérapeutiques comme le forceps pour achever l'accouchement par voie naturelle. Le forceps, une méthode qui n'est pas sans risque pour la mère et le nouveau-né. Nous avons ...

  10. Non-intrusive measurement of tritium activity in waste drums by modelling a {sup 3}He leak quantified by mass spectrometry; Mesure non intrusive de l'activite de futs de dechets trities par modelisation d'une fuite {sup 3}He et sa quantification par spectrometrie de masse

    Energy Technology Data Exchange (ETDEWEB)

    Demange, D

    2002-07-03

    This study deals with a new method that makes it possible to measure very low tritium quantities inside radioactive waste drums. This indirect method is based on measuring the decaying product, {sup 3}He, and requires a study of its behaviour inside the drum. Our model considers {sup 3}He as totally free and its leak through the polymeric joint of the drum as two distinct phenomena: permeation and laminar flow. The numerical simulations show that a pseudo-stationary state takes place. Thus, the {sup 3}He leak corresponds to the tritium activity inside the drum but it appears, however, that the leak peaks when the atmospheric pressure variations induce an overpressure in the drum. Nevertheless, the confinement of a drum in a tight chamber makes it possible to quantify the {sup 3}He leak. This is a non-intrusive measurement of its activity, which was experimentally checked by using reduced models, representing the drum and its confinement chamber. The drum's confinement was optimised to obtain a reproducible {sup 3}He leak measurement. The gaseous samples taken from the chamber were purified using selective adsorption onto activated charcoals at 77 K to remove the tritium and pre-concentrate the {sup 3}He. The samples were measured using a leak detector mass spectrometer. The adaptation of the signal acquisition and the optimisation of the analysis parameters made it possible to reach the stability of the external calibrations using standard gases with a {sup 3}He detection limit of 0.05 ppb. Repeated confinement of the reference drums demonstrated the accuracy of this method. The uncertainty of this non-intrusive measurement of the tritium activity in 200-liter drums is 15% and the detection limit is about 1 GBq after a 24 h confinement. These results led to the definition of an automated tool able to systematically measure the tritium activity of all storage waste drums. (authors)

  11. Non-intrusive measurement of tritium activity in waste drums by modelling a {sup 3}He leak quantified by mass spectrometry; Mesure non intrusive de l'activite de futs de dechets trities par modelisation d'une fuite {sup 3}He et sa quantification par spectrometrie de masse

    Energy Technology Data Exchange (ETDEWEB)

    Demange, D

    2002-07-03

    This study deals with a new method that makes it possible to measure very low tritium quantities inside radioactive waste drums. This indirect method is based on measuring the decaying product, {sup 3}He, and requires a study of its behaviour inside the drum. Our model considers {sup 3}He as totally free and its leak through the polymeric joint of the drum as two distinct phenomena: permeation and laminar flow. The numerical simulations show that a pseudo-stationary state takes place. Thus, the {sup 3}He leak corresponds to the tritium activity inside the drum but it appears, however, that the leak peaks when the atmospheric pressure variations induce an overpressure in the drum. Nevertheless, the confinement of a drum in a tight chamber makes it possible to quantify the {sup 3}He leak. This is a non-intrusive measurement of its activity, which was experimentally checked by using reduced models, representing the drum and its confinement chamber. The drum's confinement was optimised to obtain a reproducible {sup 3}He leak measurement. The gaseous samples taken from the chamber were purified using selective adsorption onto activated charcoals at 77 K to remove the tritium and pre-concentrate the {sup 3}He. The samples were measured using a leak detector mass spectrometer. The adaptation of the signal acquisition and the optimisation of the analysis parameters made it possible to reach the stability of the external calibrations using standard gases with a {sup 3}He detection limit of 0.05 ppb. Repeated confinement of the reference drums demonstrated the accuracy of this method. The uncertainty of this non-intrusive measurement of the tritium activity in 200-liter drums is 15% and the detection limit is about 1 GBq after a 24 h confinement. These results led to the definition of an automated tool able to systematically measure the tritium activity of all storage waste drums. (authors)

  12. Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1 and matrix metalloproteinase-1 (MMP-1.

    Directory of Open Access Journals (Sweden)

    Seok-Jun Kim

    Full Text Available BACKGROUND: Galectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3 silencing, we demonstrated here that galectin-3 plays a key role in up-regulating the expressions of protease-activated receptor-1 (PAR-1 and matrix metalloproteinase-1 (MMP-1 PAR-1 thereby promoting gastric cancer metastasis. METHODOLOGY/PRINCIPAL FINDINGS: We examined the expression levels of Galectin-3, PAR-1, and MMP-1 in gastric cancer patient tissues and also the effects of silencing these proteins with specific siRNAs and of over-expressing them using specific lenti-viral constructs. We also employed zebrafish embryo model for analysis of in vivo gastric cancer cell invasion. These studies demonstrated that: a galectin-3 silencing decreases the expression of PAR-1. b galectin-3 over-expression increases cell migration and invasion and this increase can be reversed by PAR-1 silencing, indicating that galectin-3 increases cell migration and invasion via PAR-1 up-regulation. c galectin-3 directly interacts with AP-1 transcriptional factor, and this complex binds to PAR-1 promoter and drives PAR-1 transcription. d galectin-3 also amplifies phospho-paxillin, a PAR-1 downstream target, by increasing MMP-1 expression. MMP-1 silencing blocks phospho-paxillin amplification and cell invasion caused by galectin-3 over-expression. e Silencing of either galectin-3, PAR-1 or MMP-1 significantly reduced cell migration into the vessels in zebrafish embryo model. f Galectin-3, PAR-1, and MMP-1 are highly expressed and co-localized in malignant tissues from gastric cancer patients. CONCLUSIONS/SIGNIFICANCE: Galectin-3 plays the key role of activating cell surface receptor through production of protease and boosts gastric cancer metastasis. Galectin-3 has the potential to serve as a useful pharmacological target for prevention of gastric cancer metastasis.

  13. CERN, a laboratory of social excellence

    CERN Multimedia

    Staff Association

    2012-01-01

    The HR 2012 Forum, where Human Resources (HR) professionals meet and present innovative services and tools in the HR sector, was held on 3rd and 4th October at Palexpo, Geneva. CERN won the 3rd HR Innovation Award for the Long-Term Saved Leave Scheme (LTSLS) for its novelty and innovation. The award was presented to Jean-Marc Saint Viteux, Deputy-Head of HR Department. This is excellent news for our Organization. One can say that the Long-Term Saved Leave Scheme (LTSLS) originated from proposals by the Staff Association in 1996, based on general considerations on a framework for flexible working time arrangements. This article recalls the history of our work on this topic, which resulted in the implementation of PRP and various variants of a saved leave scheme. In a future issue of Echo, we will come back on other elements of CERN's social policy that we would like to improve upon to ensure a better work-life balance.  Indeed, a good employer must offer a working environment that allows an...

  14. The Impact of Business Excellence on Operational Performance among Halal Certified Food Manufacturers in Malaysia

    Directory of Open Access Journals (Sweden)

    Masrom Nor Ratna

    2017-01-01

    Full Text Available The impact of business excellence with key elements embedded can be a tool for organization to determine opportunities and gain knowledge. This will help the organization to learn how to adopt highperformance and achieve competitive advantage. Through the business excellence model, the organization can execute their strategies to determine, forecast and survive in highly competitive market. This paper presents on identifying those elements in business excellence model (leadership, strategy and planning, customer focus, measurement, analysis, and knowledge management, operation focus that impact on operational performance in halal certified food manufacturers in Malaysia. Data for the study were collected from 100 halal certified food manufacturers and the relationship proposed in the framework were tested using structural equation modelling (SEM. The result indicated that all the elements of Business Excellence cannot lead to operational performance except for customer focus.

  15. The nature of excellent clinicians at an academic health science center: a qualitative study.

    Science.gov (United States)

    Mahant, Sanjay; Jovcevska, Vesna; Wadhwa, Anupma

    2012-12-01

    To understand the nature of excellent clinicians at an academic health science center by exploring how and why excellent clinicians achieve high performance. From 2008 to 2010, the authors conducted a qualitative study using a grounded theory approach. Members of the Clinical Advisory Committee in the Department of Pediatrics at the University of Toronto nominated peers whom they saw as excellent clinicians. The authors then conducted in-depth interviews with the most frequently nominated clinicians. They audio-recorded and transcribed the interviews and coded the transcripts to identify emergent themes. From interviews with 13 peer-nominated, excellent clinicians, a model emerged. Dominant themes fell into three categories: (1) core philosophy, (2) deliberate activities, and (3) everyday practice. Excellent clinicians are driven by a core philosophy defined by high intrinsic motivation and passion for patient care and humility. They refine their clinical skills through two deliberate activities-reflective clinical practice and scholarship. Their high performance in everyday practice is characterized by clinical skills and cognitive ability, people skills, engagement, and adaptability. A rich theory emerged explaining how excellent clinicians, driven by a core philosophy and engaged in deliberate activities, achieve high performance in everyday practice. This theory of the nature of excellent clinicians provides a holistic perspective of individual performance, informs medical education, supports faculty career development, and promotes clinical excellence in the culture of academic medicine.

  16. Diagnostic accuracy of 3-T magnetic resonance imaging with 3D T1 VIBE versus computer tomography in pars stress fracture of the lumbar spine

    Energy Technology Data Exchange (ETDEWEB)

    Ang, E.C.; Robertson, A.F.; Malara, F.A.; O' Shea, T.; Roebert, J.K.; Rotstein, A.H. [Victoria House Medical Imaging, Prahran, Victoria (Australia); Schneider, M.E. [Monash University, Monash Biomedicine Discovery Institute, Department of Medical Imaging and Radiation Sciences, Faculty of Medicine, Nursing and Health Sciences, Clayton, Victoria (Australia)

    2016-11-15

    To compare the diagnostic accuracy of 3-T magnetic resonance imaging (MRI) with thin-slice 3D T1 VIBE sequence to 128-slice computer tomography (CT) in pars stress fractures of the lumbar spine. 3-T MRI and CT of 24 patients involving 70 pars interarticularis were retrospectively reviewed by four blinded radiologists. The fracture morphology (complete, incomplete, or normal) was assessed on MRI and CT at different time points. Pars interarticularis bone marrow edema (present or absent) was also evaluated on MRI. In total, 14 complete fractures, 31 incomplete fractures and 25 normal pars were detected by CT. Bone marrow edema was seen in seven of the complete and 25 of the incomplete fractures. The overall sensitivity, specificity and accuracy of MRI in detecting fractures (complete and incomplete) were 97.7, 92.3, and 95.7 %, respectively. MRI was 100 % accurate in detecting complete fractures. For incomplete fractures, the sensitivity, specificity, and accuracy of MRI were 96.7, 92.0, and 94.6 %, respectively. 3-T MRI with thin-slice 3D T1 VIBE is 100 % accurate in diagnosing complete pars fractures and has excellent diagnostic ability in the detection and characterization of incomplete pars stress fractures compared to CT. MRI has the added advantages of detecting bone marrow edema and does not employ ionizing radiation. (orig.)

  17. Diagnostic accuracy of 3-T magnetic resonance imaging with 3D T1 VIBE versus computer tomography in pars stress fracture of the lumbar spine

    International Nuclear Information System (INIS)

    Ang, E.C.; Robertson, A.F.; Malara, F.A.; O'Shea, T.; Roebert, J.K.; Rotstein, A.H.; Schneider, M.E.

    2016-01-01

    To compare the diagnostic accuracy of 3-T magnetic resonance imaging (MRI) with thin-slice 3D T1 VIBE sequence to 128-slice computer tomography (CT) in pars stress fractures of the lumbar spine. 3-T MRI and CT of 24 patients involving 70 pars interarticularis were retrospectively reviewed by four blinded radiologists. The fracture morphology (complete, incomplete, or normal) was assessed on MRI and CT at different time points. Pars interarticularis bone marrow edema (present or absent) was also evaluated on MRI. In total, 14 complete fractures, 31 incomplete fractures and 25 normal pars were detected by CT. Bone marrow edema was seen in seven of the complete and 25 of the incomplete fractures. The overall sensitivity, specificity and accuracy of MRI in detecting fractures (complete and incomplete) were 97.7, 92.3, and 95.7 %, respectively. MRI was 100 % accurate in detecting complete fractures. For incomplete fractures, the sensitivity, specificity, and accuracy of MRI were 96.7, 92.0, and 94.6 %, respectively. 3-T MRI with thin-slice 3D T1 VIBE is 100 % accurate in diagnosing complete pars fractures and has excellent diagnostic ability in the detection and characterization of incomplete pars stress fractures compared to CT. MRI has the added advantages of detecting bone marrow edema and does not employ ionizing radiation. (orig.)

  18. Incorporating GOES Satellite Photosynthetically Active Radiation (PAR) Retrievals to Improve Biogenic Emission Estimates in Texas

    Science.gov (United States)

    Zhang, Rui; White, Andrew T.; Pour Biazar, Arastoo; McNider, Richard T.; Cohan, Daniel S.

    2018-01-01

    This study examines the influence of insolation and cloud retrieval products from the Geostationary Operational Environmental Satellite (GOES) system on biogenic emission estimates and ozone simulations in Texas. Compared to surface pyranometer observations, satellite-retrieved insolation and photosynthetically active radiation (PAR) values tend to systematically correct the overestimation of downwelling shortwave radiation in the Weather Research and Forecasting (WRF) model. The correlation coefficient increases from 0.93 to 0.97, and the normalized mean error decreases from 36% to 21%. The isoprene and monoterpene emissions estimated by the Model of Emissions of Gases and Aerosols from Nature are on average 20% and 5% less, respectively, when PAR from the direct satellite retrieval is used rather than the control WRF run. The reduction in biogenic emission rates using satellite PAR reduced the predicted maximum daily 8 h ozone concentration by up to 5.3 ppbV over the Dallas-Fort Worth (DFW) region on some days. However, episode average ozone response is less sensitive, with a 0.6 ppbV decrease near DFW and 0.3 ppbV increase over East Texas. The systematic overestimation of isoprene concentrations in a WRF control case is partially corrected by using satellite PAR, which observes more clouds than are simulated by WRF. Further, assimilation of GOES-derived cloud fields in WRF improved CAMx model performance for ground-level ozone over Texas. Additionally, it was found that using satellite PAR improved the model's ability to replicate the spatial pattern of satellite-derived formaldehyde columns and aircraft-observed vertical profiles of isoprene.

  19. NOBLE and EXCEL: The debate for excellence in dealing with left main stenosis.

    Science.gov (United States)

    Kindi, Hamood Al; Samaan, Amir; Hosny, Hatem

    2018-03-14

    Left main coronary artery (LMCA) disease is associated with increased morbidity and mortality. Coronary artery bypass grafting surgery (CABG) has always been the standard revascularization strategy for this group of patients. However, with the recent developments in stents design and medical therapy over the past decade, several trials have been designed to evaluate the safety and efficacy of percutaneous coronary intervention (PCI) as an alternative to CABG surgery in patients with LMCA disease. Recently, the results of two major trials, EXCEL and NOBLE, comparing CABG versus PCI in this patient population have been released. In fact, the results of both trials might appear contradictory at first glance. While the EXCEL trial showed that PCI was non-inferior to CABG surgery, the NOBLE trial suggested that CABG surgery is a better option. In the following review, we will discuss some of the similarities and contrasts between these two trials and conclude with lessons to be learned to our daily practice.

  20. Center of Excellence for Materials Research

    National Research Council Canada - National Science Library

    Khan, Akhtar

    1998-01-01

    .... The four tasks are, 'Thermomechanics of Fiber - Reinforced Elastomeric Composites', Evaluations and Modification of Constitutive Models for Finite Viscoplastic Deformation Related to Armor Design...

  1. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration.

    Science.gov (United States)

    Pichaud, Franck

    2018-01-01

    The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM) and zonula adherens (ZA) , thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1) gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  2. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration

    Directory of Open Access Journals (Sweden)

    Franck Pichaud

    2018-03-01

    Full Text Available The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM and zonula adherens (ZA, thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1 gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  3. Essentials of Excel, Excel VBA, SAS and Minitab for statistical and financial analyses

    CERN Document Server

    Lee, Cheng-Few; Chang, Jow-Ran; Tai, Tzu

    2016-01-01

    This introductory textbook for business statistics teaches statistical analysis and research methods via business case studies and financial data using Excel, MINITAB, and SAS. Every chapter in this textbook engages the reader with data of individual stock, stock indices, options, and futures. One studies and uses statistics to learn how to study, analyze, and understand a data set of particular interest. Some of the more popular statistical programs that have been developed to use statistical and computational methods to analyze data sets are SAS, SPSS, and MINITAB. Of those, we look at MINITAB and SAS in this textbook. One of the main reasons to use MINITAB is that it is the easiest to use among the popular statistical programs. We look at SAS because it is the leading statistical package used in industry. We also utilize the much less costly and ubiquitous Microsoft Excel to do statistical analysis, as the benefits of Excel have become widely recognized in the academic world and its analytical capabilities...

  4. PAR1 activation affects the neurotrophic properties of Schwann cells.

    Science.gov (United States)

    Pompili, Elena; Fabrizi, Cinzia; Somma, Francesca; Correani, Virginia; Maras, Bruno; Schininà, Maria Eugenia; Ciraci, Viviana; Artico, Marco; Fornai, Francesco; Fumagalli, Lorenzo

    2017-03-01

    Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier. Schwann cells are the principal population of glial cells of the peripheral nervous system which myelinate axons playing an important role during axonal regeneration and remyelination. The present study was undertaken in order to determine if the activation of PAR1 affects the neurotrophic properties of Schwann cells. Our results suggest that the stimulation of PAR1 could potentiate the Schwann cell ability to favour nerve regeneration. In fact, the conditioned medium obtained from Schwann cell cultures challenged with a specific PAR1 activating peptide (PAR1 AP) displays increased neuroprotective and neurotrophic properties with respect to the culture medium from untreated Schwann cells. The proteomic analysis of secreted proteins in untreated and PAR1 AP-treated Schwann cells allowed the identification of factors differentially expressed in the two samples. Some of them (such as macrophage migration inhibitory factor, matrix metalloproteinase-2, decorin, syndecan 4, complement C1r subcomponent, angiogenic factor with G patch and FHA domains 1) appear to be transcriptionally regulated after PAR1 AP treatment as shown by RT-PCR. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Modélisation du procédé de soudage hybride Arc / Laser par une approche level set application aux toles d'aciers de fortes épaisseurs A level-set approach for the modelling of hybrid arc/laser welding process application for high thickness steel sheets joining

    Directory of Open Access Journals (Sweden)

    Desmaison Olivier

    2013-11-01

    Full Text Available Le procédé de soudage hybride Arc/Laser est une solution aux assemblages difficiles de tôles de fortes épaisseurs. Ce procédé innovant associe deux sources de chaleur : un arc électrique produit par une torche MIG et une source laser placée en amont. Ce couplage améliore le rendement du procédé, la qualité du cordon et les déformations finales. La modélisation de ce procédé par une approche Level Set permet une prédiction du développement du cordon et du champ de température associé. La simulation du soudage multi-passes d'une nuance d'acier 18MnNiMo5 est présentée ici et les résultats sont comparés aux observations expérimentales. The hybrid arc/laser welding process has been developed in order to overcome the difficulties encountered for joining high thickness steel sheets. This innovative process gathers two heat sources: an arc source developed by a MIG torch and a pre-located laser source. This coupling improves the efficiency of the process, the weld bead quality and the final deformations. The Level-Set approach for the modelling of this process enables the prediction of the weld bead development and the temperature field evolution. The simulation of the multi-passes welding of a 18MnNiMo5 steel grade is detailed and the results are compared to the experimental observations.

  6. Evaluation des bassins par modélisation intégrée en deux dimensions des transferts techniques, de l'écoulement des fluides, de la genèse et de la migration des hydrocarbures Basin Evaluation by Integrated Two-Dimensional Modeling of Heat Transfer, Fluid Flow, Hydrocarbon Generation, and Migration

    Directory of Open Access Journals (Sweden)

    Chenet P. Y.

    2006-11-01

    Full Text Available Le modèle de bassin exposé dans cet article décrit les phénomènes physiques et chimiques qui contrôlent la formation d'accumulations commerciales, dans le cadre évolutif d'un bassin sédimentaire affecté par la subsidence : transfert de chaleur, compaction et écoulement de l'eau, génèse des hydrocarbures, migration diphasique de l'eau et des hydrocarbures. Le modèle tient compte des variations de conductivité et des phénomènes thermiques transitoires pour reconstituer les paléo-températures. Des validations quantitatives de la reconstitution des paléo-températures et du modèle cinétique de formation des hydrocarbures peuvent être obtenues par comparaison avec les températures actuelles et les données géochimiques. Les écoulements et les surpressions induits par la compaction sont décrits en couplant une loi de compaction avec la loi de Darcy, classique pour les écoulements de l'eau, en ajoutant un critère de fracturation hydraulique naturelle. Ceci permet de modéliser les pressions anormales dans des séquences deltaïques récentes (delta de la Mahakam, comme dans des bassins liés à des rifts anciens (mer du Nord. Une adaptation de la loi de Darcy aux écoulements diphasiques permet de reproduire la migration primaire et la migration secondaire. En particulier, le modèle permet d'étudier le rôle des pressions anormales et l'influence des failles sur la migration et le piégeage. Nos résultats confirment que les modèles de bassins peuvent contribuer à synthétiser les données géologiques, géophysiques et géochimiques dans un schéma cohérent. En précisant l'évaluation pétrolière, ces modèles constituent une des principales voies pour améliorer l'efficacité de l'exploration. The basin model discussed in this paper describes the physical and chemical phenomena that control the formation of commercial accumulations of hydrocarbons in the moving framework of a subsiding sedimentary basin : heat

  7. Investigating Complexity Using Excel and Visual Basic.

    Science.gov (United States)

    Zetie, K. P.

    2001-01-01

    Shows how some of the simple ideas in complexity can be investigated using a spreadsheet and a macro written in Visual Basic. Shows how the sandpile model of Bak, Chao, and Wiesenfeld can be simulated and animated. The model produces results that cannot easily be predicted from its properties. (Author/MM)

  8. Taare Zameen Par and dyslexic savants.

    Science.gov (United States)

    Chakravarty, Ambar

    2009-04-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely 'disinhibits' the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  9. Soudage de bois feuillus par friction rotationnelle

    OpenAIRE

    Belleville, Benoît

    2012-01-01

    Les différentes colles utilisées actuellement par l’industrie du meuble au Canada nécessitent des temps de polymérisation constituant un goulot dans la production des meubles et limitant l’atteinte de la production unitaire. Ces adhésifs synthétiques généralement issus de la pétrochimie nécessitent énormément d’énergie lors de leur confection. L’utilisation de connecteurs métalliques ou plastiques, quant à elle, limite les phases de découpage et sablage subséquentes. La présence d’adhésifs et...

  10. Intentional Excellence in the Baldwin Wallace University Neuroscience Program

    Science.gov (United States)

    Morris, Jacqueline K.; Peppers, Kieth; Mickley, G. Andrew

    2015-01-01

    The Society for Neuroscience recognized Baldwin Wallace University’s (BWU) undergraduate Neuroscience program as their Program of the Year for 2012. This award acknowledged the “accomplishments of a neuroscience department or program for excellence in educating neuroscientists and providing innovative models to which other programs can aspire.” The Neuroscience program grew out of students interested in studying the biological basis of behavior. BWU’s neuroscience major is research-intensive, and all students are required to produce an empirically-based senior thesis. This requirement challenges program resources, and the demand for faculty attention is high. Thus, we developed an intentional 3-step peer mentoring system that encourages our students to collaborate with and learn from, not only faculty, but each other. Peer mentoring occurs in the curriculum, faculty research labs, and as students complete their senior theses. As the program has grown with over 80 current majors, we have developed a new Neuroscience Methods course to train students on the safety, ethics, and practice of research in the neuroscience laboratory space. Students in this course leave with the skills and knowledge to assist senior level students with their theses and to begin the process of developing their own projects in the laboratory. Further, our students indicate that their “peer mentorship was excellent,” “helped them gain confidence,” and “allowed them to be more successful in their research.” PMID:26240522

  11. Evaluation of Business Excellence among Halal Certified Food Manufacturers in Malaysia

    Directory of Open Access Journals (Sweden)

    Masrom Nor Ratna binti

    2017-01-01

    Full Text Available Business excellence is a key tool to improve the efficiency of the company. Through the business excellence model, the organization can execute their strategies to determine, forecast and survive in highly competitive market. This paper presents on identifying those elements in business excellence model (leadership, strategy and planning, customer focus, measurement, analysis, and knowledge management, operation focus this paper provides empirical support for halal food certified companies reviewing and improvement. Survey has been done and analyzed among halal food certified manufacturers in Malaysia. Thus, seven categories with 35 key elements regarding American MBNQA and eight equations are examined. The main conclusions are that, strategy and measurement, analysis and knowledge management are the main weakness of the halal food certified manufacturers in Malaysia. Overall, halal food certified manufacturers in Malaysia is at the silver level of excellence based on the calculation.

  12. SWR 1000: Efficient design for operational excellence

    International Nuclear Information System (INIS)

    Brettschuh, W.

    2008-01-01

    The SWR 1000 boiling water reactor (BWR) offers all of the advantages associated with an advanced plant design, i.e. excellent safety performance and competitive power generation costs, in the medium capacity range (1000-1250 MW). The economic efficiency of this medium-sized plant in comparison with large-capacity designs is achieved by using very simple passive safety equipment, simplified plant operating systems, and a very simple plant configuration. Systems engineering is thus optimized, reducing dependence on electrical and instrumentation and control (I and C) systems. The fuel assemblies deployed in the SWR 1000 core are enlarged from a 10 x 10 to a 12 x 12 rod array. This cuts down the total number of fuel assemblies in the core and hence also the number of control rods and control rod drives, as well as in-core neutron flux monitors. The design owes its competitiveness to the fact that investment, maintenance and fuel cycle costs are all lower. In addition, refueling outages are shorter, thanks to the reduced scope for outage activities. For example, there are no bolted reactor internal joints, and the SWR 1000 has a permanently installed reactor vessel-to-drywell seal. Replacement of in-core detectors is carried out from below, and does not affect the critical path of the outage. Furthermore all in-service -inspections (ISIs) on the reactor pressure vessel (RPV) and its nozzles can be undertaken from the outside, so that no extended ISI outages are necessary. As in existing plants, forced coolant circulation is utilized, ensuring problem-free startup and enabling plant operators to adjust power rapidly in the high power range (70%-100%). This is achieved without moving the control rods, and allows both spectral-shift and stretch-out operation. The considerable gains provided by forced coolant circulation, in terms of operational flexibility and fuel utilization, mean that the investment and maintenance costs of the pumps are covered within just a few

  13. Academic excellence workshops in chemistry and physics

    Science.gov (United States)

    Mills, Susan Rose

    In the mid-1970's, Uri Treisman, at the University of California, Berkeley, developed an academic excellence workshop program that had important successes in increasing minority student achievement and persistence in calculus. The present dissertation research is an in-depth study of chemistry and physics workshops at the California State Polytechnic University, Pomona. Data for the first, longitudinal component of this study were obtained by tracking to Spring 1998 all workshop minority students, i.e., Latino, African American, and Native American workshop students, a random sample of non-workshop minority students, and a random sample of non-targeted students, i.e., Anglo and Asian students, enrolled in first-quarter General Chemistry or Physics during specific quarters of 1992 or 1993. Data for the second component were obtained by administering questionnaires, conducting interviews, and observing science students during Fall, 1996. Workshop participation was a significant predictor of first-quarter course grade for minority students in both chemistry and physics, while verbal and mathematics Scholastic Aptitude Test (SAT) scores were not significant predictors of beginning course grade for minority science students. The lack of predictive ability of the SAT and the importance of workshop participation in minority students' beginning science course performance are results with important implications for educators and students. In comparing pre-college achievement measures for workshop and non-targeted students, non-targeted students' mathematics SAT scores were significantly higher than chemistry and physics workshop students' scores. Nonetheless, workshop participation "leveled the field" as workshop and non-targeted students performed similarly in beginning science courses. Positive impacts of workshop participation on achievement, persistence, efficiency, social integration, and self-confidence support the continued and expanded funding of workshop programs

  14. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

    Science.gov (United States)

    Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

    2011-01-01

    This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891

  15. Excel 2013 all-in-one for dummies

    CERN Document Server

    Harvey, Greg

    2013-01-01

    The comprehensive reference, now completely up-to-date for Excel 2013! As the standard for spreadsheet applications, Excel is used worldwide - but it's not always user-friendly. However, in the hands of veteran bestselling author Greg Harvey, Excel gets a whole lot easier to understand! This handy all-in-one guide covers all the essentials, the new features, how to analyze data with Excel, and much more. The featured minibooks address Excel basics, worksheet design, formulas and functions, worksheet collaboration and review, charts and graphics, data management, data analysis, and

  16. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  17. Concerning the dynamic instability of actin homolog ParM

    International Nuclear Information System (INIS)

    Popp, David; Yamamoto, Akihiro; Iwasa, Mitsusada; Narita, Akihiro; Maeda, Kayo; Maeda, Yuichiro

    2007-01-01

    Using in vitro TIRF- and electron-microscopy, we reinvestigated the dynamics of native ParM, a prokaryotic DNA segregation protein and actin homolog. In contrast to a previous study, which used a cysteine ParM mutant, we find that the polymerization process of wild type ATP-ParM filaments consists of a polymerization phase and a subsequent steady state phase, which is dynamically unstable, like that of microtubules. We find that the apparent bidirectional polymerization of ParM, is not due to the intrinsic nature of this filament, but results from ParM forming randomly oriented bundles in the presence of crowding agents. Our results imply, that in the bacterium, ParM filaments spontaneously form bipolar bundles. Due to their intrinsic dynamic instability, ParM bundles can efficiently 'search' the cytoplasmic lumen for DNA, bind it equally well at the bipolar ends and segregate it approximately symmetrically, by the insertion of ParM subunits at either end

  18. The protein kinase SIK downregulates the polarity protein Par3

    DEFF Research Database (Denmark)

    Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta

    2018-01-01

    on Par3. Functionally, this mechanism impacts on tight junction downregulation. Furthermore, SIK contributes to the loss of epithelial polarity and examination of advanced and invasive human cancers of diverse origin displayed high levels of SIK expression and a corresponding low expression of Par3...

  19. La projection par plasma : une revue

    Science.gov (United States)

    Fauchais, P.; Grimaud, A.; Vardelle, A.; Vardelle, M.

    The quality of a plasma sprayed coating depends on numerous parameters that start to be understood due to the recent progresses in modelling and measurement techniques for plasma jets, momentum, heat and mass transfers between plasma and particles, the way the particules splat and cool down upon impact on the substrate or the previously deposited layers. In this paper, first are recalled the used measurement techniques and their limitations both for plasma jets and particles in flight. Then are underlined the importance of the different phenomena envolved in the transfers between plasma and particles such as steep temperature and chemical species density gradients around the particles, heat propagation phenomenon especially for ceramic particles and the connected evaporation effect, rarefaction effect which occurs even at atmospheric pressure. The problems related to the size and injection velocity distributions which determine the trajectory distributions and the heat treatments undergone by the particles are treated. The study of plasma generation shows on one hand for d.c. arc plasma torches the drastic influence on the plasma jets lengths and diameters of the gas injection chamber design, the gas nature, the design of the arc chamber and nozzle, the surrounding atmosphere (especially air pumping which cools down very fast the plasma) and on the other hand for RF plasmas the importance of the particle injection design to avoid the coupling between the RF discharge and the carrier gas with the particles. All these points are illustrated with examples of coatings of alumina, zirconia carbide and nickel particles. The way the particles splat is then studied with the chemical reactions in flight, the fast quenching of the particles and the resulting cristalline structures, the coating adhesion and also the residual stesses and their control through that of the temperature gradients into the coatings during spraying. At last a few actual and potential applications

  20. Contribution à l'optimisation du carottage par modélisation de l'initialisation du discage Contribution to the Optimizing of Core Drilling by Modeling the Initiation of Discing

    Directory of Open Access Journals (Sweden)

    Venet V.

    2006-11-01

    ; - de certaines gammes de valeur de la distance entre les ruptures par discage.

  1. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  2. Design of 118 MHz twelfth harmonic cavity of APS PAR

    International Nuclear Information System (INIS)

    Kang, Y.W.; Kustom, R.L.; Bridges, J.F.

    1992-01-01

    Two radio frequency (RF) cavities are needed in the Positron Accumulator Ring (PAR) of the Advanced Photon Source. One is for the first harmonic frequency at 9.8 MHz, and the other is for the twelfth harmonic frequency at 118 MHz. This note reports on the design of the 118 MHz RF cavity. Computer models are used to find the mode frequencies, impedances, Q-factors, and field distributions in the cavity. The computer codes MAFIA, URMEL, and URMEL-T are useful tools which model and simulate the resonance characteristics of a cavity. These codes employ the finite difference method to solve Maxwell's equations. MAFIA is a three-dimensional problem solver and uses square patches to approximate the inner surface of a cavity. URMEL and URMEL-T are two-dimensional problem solvers and use rectangular and triangular meshes, respectively. URMEL-T and MAFIA can handle problems with arbitrary dielectric materials located inside the boundary. The cavity employs a circularly cylindrical ceramic window to limit the vacuum to the beam pipe. The ceramic window used in the modeling will have a wall thickness of 0.9 cm. This wall thickness is not negligible in determining the resonant frequencies of the cavity. In the following, results of two- and three-dimensional modeling of the cavities using the URMEL-T and MAFIA codes are reported

  3. Evaluating treatment process redesign by applying the EFQM Excellence Model

    NARCIS (Netherlands)

    Nabitz, Udo; Schramade, Mark; Schippers, Gerard

    2006-01-01

    OBJECTIVE: To evaluate a treatment process redesign programme implementing evidence-based treatment as part of a total quality management in a Dutch addiction treatment centre. METHOD: Quality management was monitored over a period of more than 10 years in an addiction treatment centre with 550

  4. An integrated service excellence model for strategic military test

    African Journals Online (AJOL)

    gerhardc

    necessary to design, develop and implement a test and evaluation service are ... processes exist in these facilities without any common quality assurance and control .... For a performance management system to be effective, the performance.

  5. A Model for Establishing a Cybersecurity Center of Excellence

    Science.gov (United States)

    Moskal, Edward J.

    2015-01-01

    In order to effectively ensure our continued technical advantage and future cybersecurity, we need a technologically skilled and cyber savvy workforce and an effective pipeline of future employees. Our Government has identified Cybersecurity as one of the most serious economic and national security challenges we face as a nation and has ear-marked…

  6. Teaching Time Value of Money Using an Excel Retirement Model

    Science.gov (United States)

    Arellano, Fernando; Mulig, Liz; Rhame, Susan

    2012-01-01

    The time value of money (TVM) is required knowledge for all business students. It is traditionally taught in finance and accounting classes for use in various applications in the business curriculum. These concepts are also very useful in real life situations such as calculating the amount to save for retirement. This paper details a retirement…

  7. Value networks in manufacturing sustainability and performance excellence

    CERN Document Server

    Uusitalo, Teuvo

    2017-01-01

    This book highlights innovative solutions together with various techniques and methods that can help support the manufacturing sector to excel in economic, social, and environmental terms in networked business environments. The book also furthers understanding of sustainable manufacturing from the perspective of value creation in manufacturing networks, by capitalizing on the outcomes of the European ‘Sustainable Value Creation in Manufacturing Networks’ project. New dynamics and uncertainties in modern markets call for innovative solutions in the global manufacturing sector. While the manufacturing sector is traditionally driven by technology, it also requires other managerial and organizational solutions in terms of network governance, business models, sustainable solution development for products and services, performance management portals, etc., which can provide major competitive advantages for companies. At the same time, the manufacturing industry is subject to a change process, where business net...

  8. Final report for the DOE Metal Hydride Center of Excellence.

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jay O.; Klebanoff, Leonard E.

    2012-01-01

    This report summarizes the R&D activities within the U.S. Department of Energy Metal Hydride Center of Excellence (MHCoE) from March 2005 to June 2010. The purpose of the MHCoE has been to conduct highly collaborative and multi-disciplinary applied R&D to develop new reversible hydrogen storage materials that meet or exceed DOE 2010 and 2015 system goals for hydrogen storage materials. The MHCoE combines three broad areas: mechanisms and modeling (which provide a theoretically driven basis for pursuing new materials), materials development (in which new materials are synthesized and characterized) and system design and engineering (which allow these new materials to be realized as practical automotive hydrogen storage systems). This Final Report summarizes the organization and execution of the 5-year research program to develop practical hydrogen storage materials for light duty vehicles. Major results from the MHCoE are summarized, along with suggestions for future research areas.

  9. SME Customer Service Excellence: A Singaporean Case Study

    Directory of Open Access Journals (Sweden)

    Koh Kelly Sze Wee

    2016-06-01

    Full Text Available In Singapore, service sectors are dominated by SMEs. This study set out to investigate customer satisfaction as a critical factor in SME survival and indeed in helping to maintain the overall health of the economy. In this study, data were collected from a Singaporean SME which supplies and installs glass for construction projects. Departments involved were Sales & Marketing, Administration, and Installation. A questionnaire survey was administered to every customer of the company in 2013 in order to evaluate the services provided by the three departments. Customers were categorized into five groups: main contractors, designers/sub-contractors, property managers, home owners and commercial owners. Data were analyzed in terms of thirteen customer service variables identified from the literature. Statistical methods were applied to data analysis and findings were arrived at. Findings were found to be sufficiently significant to permit the formulation of a Total Customer Service Excellence Model for SMEs in Singapore.

  10. Tricyclic GyrB/ParE (TriBE inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents.

    Directory of Open Access Journals (Sweden)

    Leslie W Tari

    Full Text Available Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA topoisomerases, DNA gyrase and topoisomerase IV, are validated antibacterial drug targets with multiple prospective drug binding sites, including the catalytic site targeted by the fluoroquinolone antibiotics. However, growing resistance to fluoroquinolones, frequently mediated by mutations in the drug-binding site, is increasingly limiting the utility of this antibiotic class, prompting the search for other inhibitor classes that target different sites on the topoisomerase complexes. The highly conserved ATP-binding subunits of DNA gyrase (GyrB and topoisomerase IV (ParE have long been recognized as excellent candidates for the development of dual-targeting antibacterial agents with broad-spectrum potential. However, to date, no natural product or small molecule inhibitors targeting these sites have succeeded in the clinic, and no inhibitors of these enzymes have yet been reported with broad-spectrum antibacterial activity encompassing the majority of Gram-negative pathogens. Using structure-based drug design (SBDD, we have created a novel dual-targeting pyrimidoindole inhibitor series with exquisite potency against GyrB and ParE enzymes from a broad range of clinically important pathogens. Inhibitors from this series demonstrate potent, broad-spectrum antibacterial activity against Gram-positive and Gram-negative pathogens of clinical importance, including fluoroquinolone resistant and multidrug resistant strains. Lead compounds have been discovered with clinical potential; they are well tolerated in animals, and efficacious in Gram-negative infection models.

  11. Achieving Business Excellence by Optimizing Corporate Forensic Readiness

    Directory of Open Access Journals (Sweden)

    Gojko Grubor

    2017-02-01

    Full Text Available In order to improve their business excellence, all organizations, despite their size (small, medium or large one should manage their risk of fraud. Fraud, in today’s world, is often committed by using computers and can only be revealed by digital forensic investigator. Not even small or medium-sized companies are secure from fraud. In the light of recent financial scandals that literary demolished not just economies of specific countries but entire world economy, we propose in this paper an optimal model of corporative computer incident digital forensic investigation (CCIDFI by using adopted mathematic model of the greed MCDM – multi-criteria decision-making method and the Expert Choice software tool for multi-criteria optimization of the CCIDFI readiness. Proposed model can, first of all, help managers of small and medium-sized companies to justify their decisions to employ digital forensic investigators and include them in their information security teams in order to choose the optimal CCIDFI model and improve forensic readiness in the computer incident management process that will result with minimization of potential losses of company in the future and improve its business quality.

  12. Business Excellence Assessment - from an Integrated Reporting Perspective

    Directory of Open Access Journals (Sweden)

    Valentin Burcă

    2016-01-01

    Full Text Available Economic globalization effects can easily be seen in various levels of decision process, affecting financial performance of each entity drastically. An essential variable on the decision process that is considered by managers, shareholders and stakeholders as well is the uncertainty of the economic environment that can be reduced through a flexible and up to date financial reporting model. In the light of the last evolutions of financial reporting model, standard-setters, researchers and practitioners as well, have realized the need for a change in the financial reporting regulation. Among listed entities, on which case financial transparency is essential on gaining investors trust, there has been drawn up a change in orientation concerning financial reporting model. As the focus falls now on value added potential, the new philosophy of integrated reporting has become of high interest for managers, shareholders and stakeholders as well. The paper is trying to describe this philosophy, from the perspective of business excellence models, widely spread globally nowadays. We will try to explain the integrated reporting utility on decision process by underlining the way this voluntary corporate reporting solution can give relevant information about value added potential of a reporting entity.

  13. Modelización financiera con Excel

    Directory of Open Access Journals (Sweden)

    Lafuente Robledo, M.

    1998-01-01

    puramente didáctico facilita la comprensión y el estudio del alumno, el cual se tiene que centrar en los aspectos básicos de la asignatura, reduciéndose de forma muy importante la memorización de conceptos. · Permite determinar de manera rápida y exacta los distintos valores que sea necesario obtener y, consecuentemente, comparar entre distintas operaciones financieras planteadas al alumno de forma inmediata. · Operaciones con cálculos numéricos importantes, como la realización de cuadros de amortización de préstamos y empréstitos, también se pueden realizar con gran rapidez, y llevar a cabo un análisis de sensibilidad del mismo. · En general, permite resolver el problema hasta la solución final y extraer las conclusiones operativas, fase que en los cálculos manuales es muchas veces soslayada. Consecuentemente, facilita la detección de posibles inconsistencias y datos erróneos en los planteamientos y resultados. · La utilización de herramientas informáticas ayuda por otra parte a motivar a los alumnos como consecuencia del atractivo generalizado del soporte informático. No obstante, este aspecto no se puede generalizar a todos los alumnos, y además tiene un efecto que se diluye con el tiempo. A continuación, se desarrollan una serie de modelos de matemática financiera con hoja de cálculo con el objeto de ilustrar de forma clara y precisa como se pueden implementar dichos problemas financieros en Excel. Los tres primeros casos corresponden a la matemática financiera clásica y consideramos que deberían representar las aplicaciones informáticas mínimas de cualquier curso de esta disciplina en la Facultades y Escuelas Universitarias de Ciencias Empresariales.

  14. National Study of Excellence and Innovation in Physical Therapist Education: Part 2-A Call to Reform.

    Science.gov (United States)

    Jensen, Gail M; Hack, Laurita M; Nordstrom, Terrence; Gwyer, Janet; Mostrom, Elizabeth

    2017-09-01

    This perspective shares recommendations that draw from (1) the National Study of Excellence and Innovation in Physical Therapist Education research findings and a conceptual model of excellence in physical therapist education, (2) the Carnegie Foundation's Preparation for the Professions Program (PPP), and (3) research in the learning sciences. The 30 recommendations are linked to the dimensions described in the conceptual model for excellence in physical therapist education: Culture of Excellence, Praxis of Learning, and Organizational Structures and Resources. This perspective proposes a transformative call for reform framed across 3 core categories: (1) creating a culture of excellence, leadership, and partnership, (2) advancing the learning sciences and understanding and enacting the social contract, and (3) implementing organizational imperatives. Similar to the Carnegie studies, this perspective identifies action items (9) that should be initiated immediately in a strategic and systematic way by the major organizational stakeholders in physical therapist education. These recommendations and action items provide a transformative agenda for physical therapist education, and thus the profession, in meeting the changing needs of society through higher levels of excellence. © 2017 American Physical Therapy Association.

  15. Hemodynamic parameters and neurogenic pulmonary edema following spinal cord injury: an experimental model Parâmetros hemodinâmicos e edema pulmonar neurogênico após traumatismo raquimedular: modelo experimental

    Directory of Open Access Journals (Sweden)

    Manoel Baldoino Leal Filho

    2005-12-01

    . Apresentamos uma experiência com 58 ratos Wistar machos e adultos. Foram formados dois grupos: controle (n=4 e experimental (n=54. O grupo experimental sofreu trauma raquimedular torácico médio com o cateter-balão de Fogarty contendo 20µL de salina por 5, 15, 30 ou 60 segundos de compressão. Os ratos foram anestesiados com pentobarbital sódico (p.s., 60 mg/Kg intraperitoneal (i.p.. Foi investigada a relação entre a lesão medular e o tempo de compressão. A evolução neurológica foi quantificada e apresentada com 4, 24 e 48 horas da compressão para caracterizar a graduação da lesão nos diferentes grupos. A pior evolução ocorreu com 60 segundos de compressão. Seis animais morreram subitamente com edema pulmonar. Vinte ratos foram randomicamente distribuídos em um dos seguintes grupos: controle (1, n=4, anestesiados com p.s. i.p., 60 mg/Kg, mas sem compressão e experimental (2, n=7, anestesiados com xilasina 10 mg/Kg e ketamina 75 mg/Kg e (3, n=9, anestesiados com p.s. i.p., 60 mg/Kg. O índice pulmonar (100 x peso pulmonar / peso corporal foi 0,395 ± 0,018 no grupo controle, 0,499 ± 0,060 no grupo 2, e 0,639 ± 0,14 no grupo 3. O exame histológico da medula espinhal mostrou rupturas no parênquima e hemorragia aguda. Comparando-se o índice pulmonar com o índice morfométrico através da microscopia óptica, evidenciou-se que ocorreu edema intra-alveolar relevante para índices acima de 0,55. A presente experiência sugere que o edema pulmonar induzido pela compressão medular é de natureza neurogênica e que o tipo de anestesia utilizada no experimento poderia ter participação na gênesis do edema pulmonar.

  16. Ion-exchange resin separation applied to activation analysis (1963); Separation par resines echangeuses d'ions appliquees a l'analyse par activation (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Aubouin, G; Laverlochere, J [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1963-07-01

    The separation techniques based on ion-exchange resins have been used, in this study, for carrying out activation analyses on about thirty impurities. A separation process has been developed so as to standardise these analyses and to render them execution a matter of routine. The reparation yields obtained are excellent and make it possible to carry out analyses on samples having a large activation cross-section ween working inside a reinforced fume-cupboard. This technique has been applied to the analysis of impurities in tantalum, iron, gallium, germanium, terphenyl, and tungsten. The extension of this process to other impurities and to other matrices is now being studied. (authors) [French] Les techniques de separations sur resines echangeusee d'ions ont ete utilisees, dans cette etude, pour effectuer des analyses par activation sur une trentaine d'impuretes. Un schema de separation a ete mis au point de maniere a normaliser ces analyses et a pouvoir les faire en routine. Les rendements de separation obtenus sont excellents et permettent de proceder a des analyses d'echantillons a grande section efficace d'activation en travaillant dans une sorbonne blindee. Des applications de cette technique ont ete faites pour des analyses d'impuretes dans le tantale, le fer, le gallium, le germanium, le terphenyle, le tungstene. L'extension de ce schema a d'autres impuretes et a d'autres matrices est en cours d'etude. (auteurs)

  17. Ion-exchange resin separation applied to activation analysis (1963); Separation par resines echangeuses d'ions appliquees a l'analyse par activation (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Aubouin, G.; Laverlochere, J. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1963-07-01

    The separation techniques based on ion-exchange resins have been used, in this study, for carrying out activation analyses on about thirty impurities. A separation process has been developed so as to standardise these analyses and to render them execution a matter of routine. The reparation yields obtained are excellent and make it possible to carry out analyses on samples having a large activation cross-section ween working inside a reinforced fume-cupboard. This technique has been applied to the analysis of impurities in tantalum, iron, gallium, germanium, terphenyl, and tungsten. The extension of this process to other impurities and to other matrices is now being studied. (authors) [French] Les techniques de separations sur resines echangeusee d'ions ont ete utilisees, dans cette etude, pour effectuer des analyses par activation sur une trentaine d'impuretes. Un schema de separation a ete mis au point de maniere a normaliser ces analyses et a pouvoir les faire en routine. Les rendements de separation obtenus sont excellents et permettent de proceder a des analyses d'echantillons a grande section efficace d'activation en travaillant dans une sorbonne blindee. Des applications de cette technique ont ete faites pour des analyses d'impuretes dans le tantale, le fer, le gallium, le germanium, le terphenyle, le tungstene. L'extension de ce schema a d'autres impuretes et a d'autres matrices est en cours d'etude. (auteurs)

  18. Method of modelization assistance with bond graphs and application to qualitative diagnosis of physical systems; Methode d'aide a la modelisation par graphes de liaison et utilisation pour le diagnostic qualitatif de systemes physiques

    Energy Technology Data Exchange (ETDEWEB)

    Lucas, B.

    1994-05-15

    After having recalled the usual diagnosis techniques (failure index, decision tree) and those based on an artificial intelligence approach, the author reports a research aimed at exploring the knowledge and model generation technique. He focuses on the design of an aid to model generation tool and aid-to-diagnosis tool. The bond graph technique is shown to be adapted to the aid to model generation, and is then adapted to the aid to diagnosis. The developed tool is applied to three projects: DIADEME (a diagnosis system based on physical model), the improvement of the SEXTANT diagnosis system (an expert system for transient analysis), and the investigation on an Ariane 5 launcher component. Notably, the author uses the Reiter and Greiner algorithm

  19. Effect of incident beam and diffuse radiation on par absorption, photosynthesis and transpiration of sitka spruce - a simulation study

    International Nuclear Information System (INIS)

    Wang, Y.P.; Jarvis, P.G.

    1990-01-01

    A simulation model, Maestro, is used to study the influence of beam fraction in the incident radiation and the radiance distribution of the sky diffuse radiation on PAR absorption, photosynthesis and transpiration of a Sitka spruce (Picea sitchensis (Bong.) Carr) tree crown. It is concluded that inaccurate separation of beam and diffuse radiation leads to significant errors in estimating the amounts of PAR absorbed, photosynthesis and transpiration by a tree in the stand. Much more attention should be paid to adequate descriptions of the radiance distribution of the sky diffuse radiation under different sky conditions. A useful approach is proposed for simulating the incident global radiaiton in a physiological, process-based model

  20. Excel 2003 all-in-one desk reference for dummies

    CERN Document Server

    Harvey, Greg

    2013-01-01

    When you think of number-crunching and spreadsheets, you think of Excel, right? After Word, it's the most popular program in the Microsoft Office suite. But if technical jargon isn't your first language, you may have found Excel just a teeny bit frustrating. It can be really hard to pick your way through the many features and make Excel do what you need for it to do. Once you know how, you can use Excel to Create fill-in-the-blank forms Prepare expense reports and invoices Manage all sorts of data Keep sales and inventory records Analyze financial data and create forecasts Present informati

  1. Brewer, Maine Wastewater Treatment Plant Recognized for Excellence

    Science.gov (United States)

    The Brewer Water Pollution Control Facility was recently honored with a 2015 Regional Wastewater Treatment Plant Excellence Award by the US Environmental Protection Agency's New England regional office.

  2. Head First Excel A learner's guide to spreadsheets

    CERN Document Server

    Milton, Michael

    2010-01-01

    Do you use Excel for simple lists, but get confused and frustrated when it comes to actually doing something useful with all that data? Stop tearing your hair out: Head First Excel helps you painlessly move from spreadsheet dabbler to savvy user. Whether you're completely new to Excel or an experienced user looking to make the program work better for you, this book will help you incorporate Excel into every aspect of your workflow, from a scratch pad for data-based brainstorming to exploratory analysis with PivotTables, optimizing outcomes with Goal Seek, and presenting your conclusions wit

  3. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  4. Mechanistic study and modeling of radionuclides retention by the hydrated calcium silicates (HCS) of cements; Etude mecanistique et modelisation de la retention de radionucleides par les silicates de calcium hydrates (CSH) des ciments

    Energy Technology Data Exchange (ETDEWEB)

    Pointeau, I

    2000-09-01

    This work attempts to investigate the modelling of radioisotopes (Cs{sup +}, Pb{sup 2+}, Eu{sup 3+}) immobilization in cement matrix, in the frame of the design of engineered barrier of a deep radwaste repository. The model development concept consists of three major steps: - surface chemistry modelling of the calcium silicate hydrate CSH, used to simulate hydrated cement behaviour; - solid analysis of the batch sorption experiments: identification of the uptake mechanism; - both previous steps are used, with isotherm data, in the modelling of the radioisotopes immobilization in the CSH matrix. Final results: (all modelling are available for all the range of studied Ca/Si ratios and have been validated with predictive calculations). - A thermodynamic modelling of the CSH surface chemistry has been developed. The labile calcium and proton sorption constants on silanol sites (>SiOH) have been extracted. - Cs{sup +} is sorbed on two sites. The silanol site (weak site) has a high site density (10 sites.nm{sup -2}), which accounts for the CSH unsaturation in high [CS{sup +}]. A strong site is also identified. - Pb{sup 2+} immobilization in CSH matrix is modelled with surface equilibria and solubility equilibrium. - Eu{sup 3+} fixation has been investigated with solid analysis: Site-Selective anti Time-Resolved Luminescence Spectroscopy, XPS and SEM-EDS. Eu{sup 3+} thus does not precipitate in CSH water but is sorbed on the CSH surface (high hydroxylated environment). Europium is also (minority site) inserted in the CSH framework. (author)

  5. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

    Science.gov (United States)

    Cunningham, Margaret R; McIntosh, Kathryn A; Pediani, John D; Robben, Joris; Cooke, Alexandra E; Nilsson, Mary; Gould, Gwyn W; Mundell, Stuart; Milligan, Graeme; Plevin, Robin

    2012-05-11

    Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh supply of receptor is required to be mobilized to the cell surface for responsiveness to agonist to be sustained. Unlike other PAR subtypes, the mechanisms regulating receptor trafficking of PAR(4) remain unknown. Here, we report novel features of the intracellular trafficking of PAR(4) to the plasma membrane. PAR(4) was poorly expressed at the plasma membrane and largely retained in the endoplasmic reticulum (ER) in a complex with the COPI protein subunit β-COP1. Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR → A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4). Interestingly, co-expression with PAR(2) facilitated plasma membrane delivery of PAR(4), an effect produced through disruption of β-COP1 binding and facilitation of interaction with the chaperone protein 14-3-3ζ. Intermolecular FRET studies confirmed heterodimerization between PAR(2) and PAR(4). PAR(2) also enhanced glycosylation of PAR(4) and activation of PAR(4) signaling. Our results identify a novel regulatory role for PAR(2) in the anterograde traffic of PAR(4). PAR(2) was shown to both facilitate and abrogate protein interactions with PAR(4), impacting upon receptor localization and cell signal transduction. This work is likely to impact markedly upon the understanding of the receptor pharmacology of PAR(4) in normal physiology and disease.

  6. Study of a class of photovoltaic systems using a bond graph approach. Modeling, analysis and control; Etude d'une classe de systemes photovoltaiques par une approche bond graph. Modelisation, analyse et commande

    Energy Technology Data Exchange (ETDEWEB)

    Andoulsi, R.

    2001-12-01

    We present in this thesis a study of a class of photovoltaic system by a bond graph approach. This study concerns the modelling, the analysis and the control of some configurations including PV generator, DC/DC converters and DC motor-pumps. The modelling of the different elements of a photovoltaic system is an indispensable stage that must precede all application of sizing, identification or simulation. However, theses PV systems are of hybrid type and their modelling is complex. It is why we use a unified modelling approach based on the bond graph technique. This methodology is completely systematic and has a sufficient flexibility for allowing the introduction of different components in the system. In the first chapter, we recall the principle of functioning of a photovoltaic generator and we treat mainly the MPPT (Maximum Power Point Tracking) working. In the second chapter, we elaborate bond graph models of various photovoltaic system configurations. For the PV source, we elaborate, in a first stage, a complete model taking into account the various physical phenomena influencing the quality of the PV source. In a second stage, we deduce a reduced bond graph model more easy to use for analysis and control purposes. For the DC/DC converters, we recall the bond graph modelling of switching elements and the average bond graph of the DC/DC converters developed in the literature. Thus, we deduce the bond graphs models of the various DC/DC converters to be used. The third chapter presents a dynamic study of some configurations stability in linear procedure. In the fourth chapter, we study the feasibility of non linear controllers by input/output linearization for some configurations of PV systems. In this study, we use the concept of inverse bond graph to determine, by a bond graph approach, the expression of the control input and the nature of the stability of the internal dynamics (dynamics of zeros). The fifth chapter is dedicated for the presentation of some

  7. Hydronéphrose géante sur rein ectopique pelvien révélée par un ...

    African Journals Online (AJOL)

    R. Yassine

    L'imagerie par résonnance magnétique (MRU magnetic resonance urography) est un excellent examen diagnostic, qui permet une évaluation précise tant morphologique que fonctionnelle [7]. Elle peut-être proposée en première intention; mais dans notre contexte, du fait de sa faible disponibilité, nous n'y recourons qu'en ...

  8. Radioactive waste combustion / vitrification under arc plasma: thermal and dynamic modelling; Combustion - vitrification de dechets radioactifs par plasma d'arc: modelisation de la thermique et de la dynamique

    Energy Technology Data Exchange (ETDEWEB)

    Barthelemy, B

    2003-07-01

    This thesis concerns the thermal and dynamic modelling for a combustion/vitrification process of surrogate radioactive waste under transferred arc plasma. The writer presents the confinement processes for radioactive waste using arc plasma and the different software used to model theses processes. This is followed by a description of our experimental equipment including a plasma arc reactor and an inductive system allowing the homogenization of glass temperature. A combustion/vitrification test is described. Thermal and material balances were discussed. The temperature fields of plasma arc and the glass frit conductivity are measured. Finally, the writer describes and clarifies the equations solved for the simulations of the electrically plasma arc and the glass melting including the thin layer of glass frit coating the crucible cold walls. The modelling results are presented in the form of spatial distribution of temperature, velocity and volume power... (author)

  9. Radioactive waste combustion-vitrification under arc plasma: thermal and dynamic modelling; Combustion - vitrification de dechets radioactifs par plasma d'arc: modelisation de la thermique et de la dynamique

    Energy Technology Data Exchange (ETDEWEB)

    Barthelemy, B

    2003-06-01

    This thesis concerns the thermal and dynamic modelling for a combustion/vitrification process of surrogate radioactive waste under transferred arc plasma. The writer presents the confinement processes for radioactive waste using arc plasma and the different software used to model theses processes. This is followed by a description of our experimental equipment including a plasma arc reactor and an inductive system allowing the homogenization of glass temperature. A combustion/vitrification test is described. Thermal and material balances were discussed. The temperature fields of plasma arc and the glass frit conductivity are measured. Finally, the writer describes and clarifies the equations solved for the simulations of the electrically plasma arc and the glass melting including the thin layer of glass frit coating the crucible cold walls. The modelling results are presented in the form of spatial distribution of temperature, velocity and voluminal power... (author)

  10. Modelling and numerical simulation of two-phase flows using the two-fluid two-pressure approach; Modelisation et simulation numerique des ecoulements diphasiques par une approche bifluide a deux pressions

    Energy Technology Data Exchange (ETDEWEB)

    Guillemaud, V

    2007-03-15

    This thesis is devoted to the modelling and numerical simulation of liquid-vapor flows. In order to describe these phase transition flows, a two-fluid two-pressure approach is considered. This description of the liquid-vapor mixing is associated to the seven-equation model introduced by Baer and Nunziato. This work investigates the properties of this model in order to simulate the phase transition flows occurring in nuclear engineering. First, a theoretical thermodynamic framework is constructed to describe the liquid-vapor mixing. Provided with this framework, various modelling choices are suggested for the interaction terms between the phases. These closure laws comply with an entropy inequality. The mathematical properties of this model are thereafter examined. The convective part is associated to a nonconservative hyperbolic system. First, we focus on the definition of its weak solutions. Several flow regimes for the two-phase mixing derive from this analysis. Such regimes for the two-phase flows are analogous to the torrential and fluvial regimes for the shallow-water equations. Furthermore, we establish the linear and nonlinear stabilities of the liquid-vapor equilibrium. Finally, the implementation of a turbulence model and the introduction of a reconstruction process for the interfacial area are investigated in order to refine the description of the interfacial transfers. Using a fractional step approach, a Finite Volume method is at last constructed to simulate this model. First, various nonconservative adaptations of standard Riemann solvers are developed to approach the convective part. Unlike the classic nonconservative framework, these schemes converge towards the same solution. Furthermore, a new relaxation scheme is proposed to approach the interfacial transfers. Provided with these schemes, the whole numerical method preserves the liquid-vapor equilibria. Using this numerical method, a careful comparison between the one- and two-pressure two

  11. Optimisation of a thermal storage installation in Wollerau. Appendix 1; Optimisation par simulation calee de l'installation de stockage Wollerau. Annexe 1: modele de simulation pour l'installation de Wollerau

    Energy Technology Data Exchange (ETDEWEB)

    Pahud, D.

    2003-07-01

    This appendix to a final report for the Swiss Federal Office of Energy describes the dynamic simulation models and parameters developed at the University of Applied Science of Southern Switzerland that were used for the simulation of the heating and cooling system of an industrial building in Wollerau, Switzerland. The models used to simulate the principal components of the system are described. The quantities calculated by the system and the simulation parameters used for the reference system are discussed and the energy-balance simulated is presented.

  12. Solution-printed organic semiconductor blends exhibiting transport properties on par with single crystals.

    Science.gov (United States)

    Niazi, Muhammad R; Li, Ruipeng; Qiang Li, Er; Kirmani, Ahmad R; Abdelsamie, Maged; Wang, Qingxiao; Pan, Wenyang; Payne, Marcia M; Anthony, John E; Smilgies, Detlef-M; Thoroddsen, Sigurdur T; Giannelis, Emmanuel P; Amassian, Aram

    2015-11-23

    Solution-printed organic semiconductors have emerged in recent years as promising contenders for roll-to-roll manufacturing of electronic and optoelectronic circuits. The stringent performance requirements for organic thin-film transistors (OTFTs) in terms of carrier mobility, switching speed, turn-on voltage and uniformity over large areas require performance currently achieved by organic single-crystal devices, but these suffer from scale-up challenges. Here we present a new method based on blade coating of a blend of conjugated small molecules and amorphous insulating polymers to produce OTFTs with consistently excellent performance characteristics (carrier mobility as high as 6.7 cm(2) V(-1) s(-1), low threshold voltages oforganic semiconductor films with transport properties and other figures of merit on par with their single-crystal counterparts.

  13. Artificial neural network based model to calculate the environmental variables of the tobacco drying process; Modelo basado en redes neuronales artificiales para el cálculo de parámetros ambientales en el proceso de curado del tabaco

    Directory of Open Access Journals (Sweden)

    Víctor Martínez-Martínez

    2013-06-01

    Full Text Available This paper presents an Artificial Neural Network (ANN based model for environmental variables related to the tobacco drying process. A fitting ANN was used to estimate and predict temperature and relative humidity inside the tobacco dryer: the estimation consists of calculating the value of these variables in different locations of the dryer and the prediction consists of forecasting the value of these variables with different time horizons. The proposed model has been validated with temperature and relative humidity data obtained from a real tobacco dryer using a Wireless Sensor Network (WSN. On the one hand, an error under 2% was achieved, obtaining temperature as a function of temperature and relative humidity in other locations in the estimation task. Besides, an error around 1.5 times lower than the one obtained with an interpolation method was achieved in the prediction task when the temperature inside the tobacco mass was predicted with time horizons over 2.5 hours as a function of its present and past values. These results show that ANN-based models can be used to improve the tobacco drying process because with these types of models the value of environmental variables can be predicted in the near future and can be estimated in other locations with low errors.

  14. Modeling of gas condensates properties using continuous distribution functions for the characterization of the plus fraction; Modelisation des proprietes thermodynamiques des gaz a condensat par representation de la fraction lourde a l`aide de fonctions de distribution

    Energy Technology Data Exchange (ETDEWEB)

    Sportisse, M.

    1996-12-20

    The modeling of thermodynamic behaviour for gas condensates is not yet satisfactory and it involves an adjustment of thermodynamic models. We propose here a fitting based on the characterization of the plus fraction using three continuous distribution functions associated to the following families: n-alkanes, n-alkylbenzenes and poly-aromatics. No continuous thermodynamic model is used and PVT calculations are made with the Peng-Robinson equation of state. For poly-aromatics, a simple correlation of {l_brace} T{sub c}, P{sub c}, {omega} {r_brace} is given. The parameters of the distributions are fitted in order to improve the accuracy of the liquid deposit curve calculation. A continuous minimization by simulated annealing has been used to avoid local minima. Good results on fitting PVT properties have been obtained with more than twenty gas condensates from different areas. Moreover, the prediction of tank liquid and heavy-plus fraction densities are given with an average deviation of 1.2 % and 3.6 %. Tests on temperature extrapolation show that our modeling yields a good representation of pressure and temperature influence on gas condensates behaviour. (author) 89 refs.

  15. Modelling of air flows in pleated filters and of their clogging by solid particles; Modelisation des ecoulements d'air et du colmatage des filtres plisses par des aerosols solides

    Energy Technology Data Exchange (ETDEWEB)

    Del Fabbro, L

    2002-07-01

    The devices of air cleaning against particles are widely spread in various branches of industry: nuclear, motor, food, electronic,...; among these devices, numerous are constituted by pleated porous media to increase the surface of filtration and thus to reduce the pressure drop, for given air flow. The objective of our work is to compensate a lack evident of knowledge on the evolution of the pressure drop of pleated filter during the clogging and to deduct a modelling from it, on the basis of experiments concerning industrial filters of nuclear and car types. The obtained model is a function of characteristics of the filtering medium and pleats, of the characteristics of solid particles deposited on the filter, of the mass of particles and of the aeraulic conditions of air flow. It also depends on data on the clogging of flat filters of equivalent medium. To elaborate this model of pressure drop, an initial stage was carried out in order to characterize, experimentally and numerically, the pressure drop and the distribution of air flow in clean pleated filters of nuclear (high efficiency particulate air filter, in fiberglasses) and car (mean efficiency filter, in fibers of cellulose) types. The numerical model allowed to understand the fundamental role played by the aeraulic resistance of the filtering medium. From an non-dimensional approach, we established a semi-empirical model of pressure drop for a clean pleated filter valid for both studied types of medium; this model is used of first base for the development of the final model of clogging. The study of the clogging of the filters showed the complexity of the phenomenon dependent mainly on a reduction of the surface of filtration. This observation brings us to propose a clogging of pleated filters in three phases. Both first phases are similar in those observed for flat filters, while last phase corresponds to a reduction of the surface of filtration and leads a strong increase of the filter pressure drop

  16. Numerical modeling of the thermomechanical behavior of networks of underground galleries for the storage of the radioactive waste: approach by homogenization; Modelisation numerique du comportement thermomecanique de reseaux de galeries souterraines pour le stockage des dechets radioactifs: Approche par homogeneisation

    Energy Technology Data Exchange (ETDEWEB)

    Zokimila, P

    2005-10-15

    Deep geological disposal is one of the privileged options for the storage of High Level radioactive waste. A good knowledge of the behavior and properties of the potential geological formations as well as theirs evolution in time under the effect of the stress change induced by a possible installation of storage is required. The geological formation host will be subjected to mechanical and thermal solicitations due respectively to the excavation of the disposal tunnels and the release of heat of the canisters of radioactive waste. These thermomechanical solicitations will generate a stress relief in the host layer and disposal tunnels deformations as well as the extension of the damaged zones (EDZ) could cause local and global instabilities. This work aims to develop calculation methods to optimize numerical modeling of the thermoelastic behavior of the disposal at a large scale and to evaluate thermomechanical disturbance induced by storage on the geological formation host. Accordingly, after a presentation of the state of knowledge on the thermomechanical aspects of the rocks related to deep storage, of numerical modeling 2D and 3D of the thermoelastic behavior of individual disposal tunnel and a network of tunnels were carried out by a discrete approach. However, this classical approach is penalizing to study the global behavior of disposal storage. To mitigate that, an approach of numerical modeling, based on homogenization of periodic structures, was proposed. Formulations as numerical procedures were worked out to calculate the effective thermoelastic behavior of an equivalent heterogeneous structure. The model, obtained by this method, was validated with existing methods of homogenization such as the self-consistent model, as well as the Hashin-Shtrikman bounds. The comparison between the effective thermoelastic behavior and current thermoelastic behavior of reference showed a good coherence of the results. For an application to deep geological storage, the

  17. Thermal Evolution of Crude Oils in Sedimentary Basins: Experimental Simulation in a Confined System and Kinetic Modeling Evolution thermique des huiles dans les bassins sédimentaires : simulation expérimentale par pyrolyse en milieu confiné et modélisation cinétique

    Directory of Open Access Journals (Sweden)

    Behar F.

    2006-11-01

    Full Text Available A detailed knowledge of the cracking mechanisms of crude oils should highly improve the understanding of geochemical reactions involved in hydrocarbon degradation into lighter oil and gas and consequently the applicability of kinetic models currently used for prediction of gas formation. Although the mechanisms of cracking are well known for several model compounds or simple mixtures, there is, to date, no available method to model complex mixtures, especially when they contain heavy compounds, except by using empirical approaches. During thermal cracking, oil will produce both lighter and heavier molecules than those present in the initial sample. Thus, the pyrolysate will be a mixture of both new compounds and compounds not yet degraded. In order to discriminate between reactants and products, we have chosen to fractionate each oil into two classes : the first one (distillate 300- comprising light hydrocarbons ranging from C6 to C16 the second one (residue 300+ comprising both hydrocarbons and polar compounds. For simulation of thermal evolution of crude oils, about 100 experiments were carried out on two oils (Boscan and Pematang, in a closed pyrolysis system, over a wide range of heating times (few minutes to 1 month and temperatures (335 to 500°C. The pyrolysate is represented by 10 chemical fractions (C1, C2, C3-C5, C6-C13 saturates, benzene + toluene + xylenes + naphthalene, C9-C13 alkyl aromatics, C14+ saturates, C14+ condensed aromatics, C14+ alkyl and/or naphtheno aromatics + resins + asphaltenes and coke. For kinetic modeling, the degradation of each fraction, except for C1, C6-C13 aromatic mixture comprising benzene, toluene, xylenes and naphthalene, and coke considered as stable compounds, is described by a balanced elementary reaction governed by first order kinetics and obeying Arrhenius law. For a given oil, the kinetic parameters of the model (apparent activation energies Ei, preexponential factor A and stoichiometric

  18. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

    DEFF Research Database (Denmark)

    Connolly, Brian M; Choi, Eun Young; Gårdsvoll, Henrik

    2010-01-01

    the interaction between endogenous uPA and uPAR is selectively abrogated, whereas other functions of both the protease and its receptor are retained. Specifically, we introduced 4 amino acid substitutions into the growth factor domain (GFD) of uPA that abrogate uPAR binding while preserving the overall structure...... a principal in vivo role of the uPA-uPAR interaction in cell-associated fibrinolysis critical for suppression of fibrin accumulation and fibrin-associated inflammation and provides a valuable model for further exploration of this multifunctional receptor....

  19. DOE Chair of Excellence Professorship in Environmental Disciplines

    Energy Technology Data Exchange (ETDEWEB)

    Shoou-Yuh Chang

    2013-01-31

    The United States (US) nuclear weapons program during the Cold War left a legacy of radioactive, hazardous, chemical wastes and facilities that may seriously harm the environment and people even today. Widespread public concern about the environmental pollution has created an extraordinary demand for the treatment and disposal of wastes in a manner to protect the public health and safety. The pollution abatement and environmental protection require an understanding of technical, regulatory, economic, permitting, institutional, and public policy issues. Scientists and engineers have a major role in this national effort to clean our environment, especially in developing alternative solutions and evaluation criteria and designing the necessary facilities to implement the solutions. The objective of the DOE Chair of Excellence project is to develop a high quality educational and research program in environmental engineering at North Carolina A&T State University (A&T). This project aims to increase the number of graduate and undergraduate students trained in environmental areas while developing a faculty concentrated in environmental education and research. Although A&T had a well developed environmental program prior to the Massie Chair grant, A&T's goal is to become a model of excellence in environmental engineering through the program's support. The program will provide a catalyst to enhance collaboration of faculty and students among various engineering departments to work together in a focus research area. The collaboration will be expanded to other programs at A&T. The past research focus areas include: hazardous and radioactive waste treatment and disposal fate and transport of hazardous chemicals in the environment innovative technologies for hazardous waste site remediation pollution prevention Starting from 2005, the new research focus was in the improvement of accuracy for radioactive contaminant transport models by ensemble based data assimilation

  20. Positron Accumulator Ring (PAR) power supply

    International Nuclear Information System (INIS)

    Fathizadeh, M.

    1995-01-01

    The Positron Accumulator Ring (PAR) consists of 8 dipole magnets connected in series. These magnets are energized via one 12-pulse dc power supply. The power supply consists of four phase controlled half-wave wye group converters. Each of the two half-wave converters are connected through an interphase transformer to obtain a full-wave converter with 120 degrees conduction. The input voltage for these two half-wave converters are 180 degrees apart. The two full-wave converters are connected in parallel through a third interphase transformer. This type of connection of the converters not only provides the required output current, it also improves the input power factor of the power supply. The output of the wye group converters is filtered through a passive L-R-C filter to reduce the ripple content of the output current. At low current values of the power supply the current ripple is high, thus a large filter is needed, which adds to the cost of the power supply, however at high output current levels, the current ripple is less severe. The large size of the filter can be reduced by adding an anti-parallel rectifier diode(D1) to the output of the power supply. A freewheeling diode(D2) is connected before the choke to circulate the current once the power supply is turned off. In order to measure the current in the magnet a high precision, low drift, zero flux current transductor is used. This transductor senses the magnet current which provides a feedback signal to control the gating of the converter's thyristors. A true 14 bit Digital to Analog Converter (DAC) is programmed by the control computer for the required current value, providing a reference for the current regulator. Fast correction of the line transients is provided by a relatively fast voltage loop controlled by a high gain slow response current loop