Anti myelin oligodendrocyte glycoprotein associated immunoglobulin G (AntiMOG-IgG-associated neuromyelitis optica spectrum disorder with persistent disease activity and residual cognitive impairment

Directory of Open Access Journals (Sweden)

Lekha Pandit

2017-01-01

Full Text Available Antibodies targeting myelin oligodendrocyte glycoprotein (MOG have been recently reported in association with idiopathic inflammatory central nervous system disorders. Initially believed to be a benign disorder, anti MOG-IgG was noted to cause steroid responsive recurrent optic neuritis and isolated longitudinally extensive myelitis. However, there is growing evidence that the disease may be predominantly relapsing, often producing severe visual loss and involving regions other than the spinal cord and optic nerve. We report an adolescent male with an aggressive disease course previously undescribed in anti MOG-IgG-associated disease that left him with residual cognitive dysfunction.

A Novel Nonsense Variant in Nav1.5 Cofactor MOG1 Eliminates Its Sodium Current Increasing Effect and May Increase the Risk of Arrhythmias

DEFF Research Database (Denmark)

Olesen, Morten S; Jensen, Niels F; Holst, Anders G

2011-01-01

at a lower frequency (1.8% vs 0.4%, P = 0.078). Electrophysiological investigation showed that the p.E61X variant completely eliminates the sodium current-increasing effect of MOG1 and thereby causes loss of function in the sodium current. When mimicking heterozygosity by coexpression of Nav1.5 with wild......BACKGROUND: The protein MOG1 is a cofactor of the cardiac sodium channel, Nav1.5. Overexpression of MOG1 in Nav1.5-expressing cells increases sodium current markedly. Mutations in the genes encoding Nav1.5 and its accessory proteins have been associated with cardiac arrhythmias of significant...... and 23 were patients with Brugada syndrome. The effect of one variant was investigated functionally by patch-clamping CHO-K1 cells coexpressing Nav1.5 with MOG1. RESULTS: We uncovered a novel heterozygous nonsense variant, c.181G>T (p.E61X), that, however, was also present in control subjects, albeit...

Neuromyelitis optica spectrum disorders: comparison of clinical and magnetic resonance imaging characteristics of AQP4-IgG versus MOG-IgG seropositive cases in the Netherlands.

Science.gov (United States)

van Pelt, E D; Wong, Y Y M; Ketelslegers, I A; Hamann, D; Hintzen, R Q

2016-03-01

Neuromyelitis optica spectrum disorders (NMOSDs) are a group of rare inflammatory demyelinating disorders of the central nervous system. The identification of specific antibodies directed to aquaporin 4 (AQP4-IgG) led to the distinction from multiple sclerosis. However, up to 25% of the clinically diagnosed NMO patients are seronegative for AQP4-IgG. A subgroup of these patients might be identified by antibodies directed to myelin oligodendrocyte glycoprotein (MOG-IgG). Our objective was to investigate whether the clinical characteristics of these patients differ. Using a cell-based assay, samples of 61 AQP4-IgG seronegative patients and 41 AQP4-IgG seropositive patients with clinically NMOSD were analysed for the presence of MOG-IgG. Clinical characteristics of the AQP4-IgG, MOG-IgG seropositive and double seronegative NMOSD patients were compared. Twenty of the 61 AQP4-IgG seronegative patients tested MOG-IgG seropositive (33%). MOG-IgG seropositive patients were more frequently males in contrast to AQP4-IgG seropositive patients (55% vs. 15%, P < 0.01) and Caucasians (90% vs. 63%, P = 0.03). They more frequently presented with coincident optic neuritis and transverse myelitis (40% vs. 12%, P = 0.02) and had a monophasic disease course (70% vs. 29%, P < 0.01). AQP4-IgG seropositive patients were 2.4 times more likely to suffer from relapses compared with MOG-IgG seropositive patients (relative risk 2.4, 95% confidence interval 1.2-4.7). AQP4-IgG seropositive patients had higher Expanded Disability Status Scale levels at last follow-up (P < 0.01). Antibodies directed to MOG identify a subgroup of AQP4-IgG seronegative NMO patients with generally a favourable monophasic disease course. © 2015 EAN.

A one-step in-situ assembly strategy to construct PEG@MOG-100-Fe shape-stabilized composite phase change material with enhanced storage capacity for thermal energy storage

Science.gov (United States)

Wang, Junyong; Andriamitantsoa, Radoelizo S.; Atinafu, Dimberu G.; Gao, Hongyi; Dong, Wenjun; Wang, Ge

2018-03-01

A novel in-situ assembly strategy has been developed to synthesis polyethylene glycol (PEG)@iron-benzenetricarboxylate metal-organic gel (MOG-100-Fe) shape-stabilized composite phase change materials by regulating metal-to-ligand ratio. The PEG@MOG-100-Fe was prepared by an ingenious introduction of PEG into the traditional sol-gel prepared MOG-100-Fe. The composite exhibited high heat storage density and thermal stability. The PEG loading content reached up to 92% without any leakage above its melting point. The heat storage density reaches to 152.88

Advancement of Miniature Optic Gas Sensor (MOGS) Probe Technology

Science.gov (United States)

Chullen, Cinda

2015-01-01

Advancement of Miniature Optic Gas Sensor (MOGS) Probe Technology" project will investigate newly developed optic gas sensors delivered from a Small Business Innovative Research (SBIR) Phase II effort. A ventilation test rig will be designed and fabricated to test the sensors while integrated with a Suited Manikin Test Apparatus (SMTA). Once the sensors are integrated, a series of test points will be completed to verify that the sensors can withstand Advanced Suit Portable Life Support System (PLSS) environments and associated human metabolic profiles for changes in pressure and levels of Oxygen (ppO2), carbon dioxide (ppCO2), and humidity (ppH2O).

MOG-IgG in NMO and related disorders: A multicenter study of 50 patients. Part 2

DEFF Research Database (Denmark)

Jarius, Sven; Ruprecht, Klemens; Kleiter, Ingo

2016-01-01

), and electrophysiological features of a large cohort of MOG-IgG-positive patients with optic neuritis (ON) and/or myelitis (n=50) as well as attack and long-term treatment outcomes. Methods: Retrospective multicenter study. Results: The sex ratio was 1:2.8 (m:f). Median age at onset was 31years (range 6-70). The disease......; end-of-dose relapses occurred 9-12 months after the first infusion. Coexisting autoimmunity was rare (9%). Wingerchuk's 2006 and 2015 criteria for NMO(SD) and Barkhof and McDonald criteria for multiple sclerosis (MS) were met by 28%, 32%, 15%, 33%, respectively; MS had been suspected in 36%. Disease...... severe disease course and the short median time to second attack support the use of prophylactic long-term treatments in patients with MOG-IgG-positive ON and/or myelitis. © 2016 The Author(s)....

Active induction of experimental autoimmune encephalomyelitis by MOG35-55 peptide immunization is associated with differential responses in separate compartments of the choroid plexus

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Murugesan Nivetha

2012-08-01

Full Text Available Abstract Background There is increasing awareness that, aside from producing cerebrospinal fluid, the choroid plexus (CP might be a key regulator of immune activity in the central nervous system (CNS during neuroinflammation. Specifically, the CP has recently been posited to control entry of sentinel T cells into the uninflamed CNS during the early stages of neuroinflammatory diseases, like multiple sclerosis (MS and its animal model experimental autoimmune encephalomyelitis (EAE. As the CP is compartmentalized into a stromal core containing fenestrated capillaries devoid of typical blood–brain barrier properties, surrounded by a tight junction-expressing choroidal epithelium, each of these compartments might mount unique responses that instigate the neuroinflammatory process. Methods To discern responses of the respective CP stromal capillary and choroidal epithelial tissues during evolving neuroinflammation, we investigated morphology and in situ expression of 93 immune-related genes during early stages of EAE induced by immunization with myelin oligodendrocyte glycoprotein peptide (MOG35-55. Specifically, 3-D immunofluorescent imaging was employed to gauge morphological changes, and laser capture microdissection was coupled to an Immune Panel TaqMan Low Density Array to detail alterations in gene expression patterns at these separate CP sites on days 9 and 15 post-immunization (p.i.. To resolve CP effects due to autoimmunity against MOG peptide, from those due to complete Freund’s adjuvant (CFA and pertussis toxin (PTX included in the immunization, analysis was performed on MOG-CFA/PTX-treated, CFA/PTX-treated, and naïve cohorts. Results The CP became swollen and displayed significant molecular changes in response to MOG-CFA/PTX immunization. Both stromal capillary and choroidal epithelial tissues mounted vigorous, yet different, changes in expression of numerous genes over the time course analyzed - including those encoding adhesion

Comparison of spontaneous brain activity revealed by regional homogeneity in AQP4-IgG neuromyelitis optica-optic neuritis versus MOG-IgG optic neuritis patients: a resting-state functional MRI study

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Wang J

2017-10-01

Full Text Available Junqing Wang,1,* Yuan Tian,2,* Yi Shao,3,* Hui Feng,1 Limin Qin,1 Weiwei Xu,1 Hongjuan Liu,1 Quangang Xu,1 Shihui Wei,1 Lin Ma2 1Department of Ophthalmology, 2Department of Radiology, Chinese PLA General Hospital, Beijing, 3Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: Many previous studies have demonstrated that neuromyelitis optica (NMO patients have abnormalities of brain anatomy and function. However, differences in spontaneous brain activity between myelin oligodendrocyte glycoprotein (MOG-IgG ON and aquaporin 4(AQP4-neuromyelitis optica-optic neuritis (ON remain unknown. In the current study, we investigated the brain neural homogeneity in MOG-IgG ON versus AQP4-IgG NMO-ON subjects by regional homogeneity (ReHo method using magnetic resonance imaging (MRI. Patients and methods: A total of 32 NMO-ON and ON subjects (21 with AQP4-IgG+NMO-ON and 11 with MOG-IgG+ON and 34 healthy controls (HCs closely matched for age were recruited, and scans were performed for all subjects. A one-way analysis of variance (ANOVA was performed to determine the regions in which the ReHo was different across the three groups. NMO-ON and ON subjects were distinguished from HCs by a receiver operating characteristic (ROC curve. The relationship between the mean ReHo in many brain regions and clinical features in NMO subjects was calculated by Pearson correlation analysis. Results: Compared with HCs, MOG-IgG+ON subjects had significantly decreased ReHo values in the posterior lobe of the left cerebellum and increased ReHo values in the left inferior frontal gyrus, right prefrontal gyrus, and left precentral/postcentral gyrus. AQP4-IgG+NMO-ON subjects showed higher ReHo values in the left inferior frontal gyrus and right middle temporal/occipital gyrus. Compared with MOG-IgG+ON subjects, AQP4-IgG+NMO-ON subjects had lower Re

Commercial gas utilization in the Netherlands. Six years of the Marketing Plan Public Gas Supply (MOG)

International Nuclear Information System (INIS)

Hoelen, Q.E.J.J.M.; Bartholomeus, P.H.J.; Mallon, W.Ch.

1998-01-01

In 1992, Gasunie (Dutch natural gas trading company) started its marketing plan for the public natural gas supply (MOG, abbreviated in Dutch). The aim is to promote the use of natural gas in cooperation with gas utilities. For the commercial sector many different gas appliances are available: high-efficiency deep-frying pans for the catering sector, gas-fired air humidifiers for office and public buildings, gas-fired tumble dryers for small and medium-sized businesses, etc

On the cosmology of scalar-tensor-vector gravity theory

Science.gov (United States)

Jamali, Sara; Roshan, Mahmood; Amendola, Luca

2018-01-01

We consider the cosmological consequences of a special scalar-tensor-vector theory of gravity, known as MOG (for MOdified Gravity), proposed to address the dark matter problem. This theory introduces two scalar fields G(x) and μ(x), and one vector field phiα(x), in addition to the metric tensor. We set the corresponding self-interaction potentials to zero, as in the standard form of MOG. Then using the phase space analysis in the flat Friedmann-Robertson-Walker background, we show that the theory possesses a viable sequence of cosmological epochs with acceptable time dependency for the cosmic scale factor. We also investigate MOG's potential as a dark energy model and show that extra fields in MOG cannot provide a late time accelerated expansion. Furthermore, using a dynamical system approach to solve the non-linear field equations numerically, we calculate the angular size of the sound horizon, i.e. θs, in MOG. We find that 8× 10‑3rad<θs<8.2× 10‑3 rad which is way outside the current observational bounds. Finally, we generalize MOG to a modified form called mMOG, and we find that mMOG passes the sound-horizon constraint. However, mMOG also cannot be considered as a dark energy model unless one adds a cosmological constant, and more importantly, the matter dominated era is still slightly different from the standard case.

Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis

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Aigner Ludwig

2008-05-01

Full Text Available Abstract Background Experimental autoimmune encephalomyelitis (EAE induced by myelin oligodendrocyte protein (MOG in female Dark Agouti (DA rats is a chronic demyelinating animal model of multiple sclerosis (MS. To identify new candidate molecules involved in the evolution or repair of EAE-lesions we used Affymetrix oligonucleotide microarrays to compare the spinal cord transcriptome at the peak of EAE, during remission and at the first relapse with healthy DA rats. Methods Untreated DA rats and DA rats immunised with MOG protein were sacrificed at defined time points. Total RNA was isolated from spinal cord tissue and used for hybridization of Affymetrix rat genome arrays RG U34 A-C. Selected expression values were confirmed by RealTime PCR. Adult neural stem cells were incubated with recombinant secretory leukocyte protease inhibitor (SLPI. Proliferation was assessed by BrdU incorporation, cyclin D1 and HES1 expression by RealTime PCR, cell differentiation by immunofluorescence analysis and IkappaBalpha degradation by Western blot. Results Among approximately 26,000 transcripts studied more than 1,100 were differentially regulated. Focussing on functional themes, we noticed a sustained downregulation of most of the transcripts of the cholesterol biosynthesis pathway. Furthermore, we found new candidate genes possibly contributing to regenerative processes in the spinal cord. Twelve transcripts were solely upregulated in the recovery phase, including genes not previously associated with repair processes. Expression of SLPI was upregulated more than hundredfold during EAE attack. Using immunohistochemistry, SLPI was identified in macrophages, activated microglia, neuronal cells and astrocytes. Incubation of adult neural stem cells (NSC with recombinant SLPI resulted in an increase of cell proliferation and of differentiation towards oligodendrocytes. These processes were paralleled by an upregulation of the cell-cycle promotor cyclin D1 and a

The establishment of a multiple sclerosis model for clinical MRI study

International Nuclear Information System (INIS)

Zhang Haiqin; Li Kuncheng; Yu Chunshui; Ma Jia; Qin Wen; Ji Zhijuan; Piao Yueshan

2009-01-01

Objective: To establish a rat model of multiple sclerosis (MS) for clinical MRI study. Methods: The Lewis (LEW) rats were immunized by myelin oligodendrocyte glycoprotein peptide 35-55 (MOG 35-55 ) emulsified with complete Freunds adjuvant/incomplete Freunds adjuvant. Twenty LEW rats were selected. Group A rats were 5, group B rats were 10 and control group rats were 5. MRI and histopathology analysis were observed on group A and control group, and clinical course were observed on group B. The clinical course was observed and the brain and spinal cord of EAE rats were scanned on 3.0 T MR system with quadrature wrist joint coil on the third day of the acute stage of disease. The T 2 /T 1 weighted images and Gadolinium enhanced T 1 weighted images in 3D volume were obtained respectively. The magnetization transfer ratio (MTR) images were calculated with special software in workstation. Rats were sacrificed within 24 h after MRI, and the histopathological changes of central nervous system were observed. Results: Twice immunization of MOG 35-55 was used and a rat model of MS was successfully induced with all the rats. The model had varied clinical symptoms. The lesions of central nervous system at acute stage on group A (5 rats) were depicted on MRI. The lesions located in the brain and the spinal cord with main manifestation of hyperintensity on T 2 weighed images and hypointensity on T 1 weighted images. Some lesions had Gd-DTPA enhancement, and the value of MTR decreased. The infiltration of mononuclear cells around blood vessels and the extensive distribution of lesions of demyelination in brain and spinal cord were verified by histological examination. Conclusions: Twice immunization of MOG 35-55 could produce a rat model which mimics MS. The model is stable with higher incidence, and the antigen is cheap and obtained easily. The intravital monitoring of brain and spinal cord lesions in MOG 35-55 induced rat model is possible on 3.0 T clinical whole- body MR

Regulation of an Autoimmune Model for Multiple Sclerosis in Th2-Biased GATA3 Transgenic Mice

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Viromi Fernando

2014-01-01

Full Text Available T helper (Th2 cells have been proposed to play a neuroprotective role in multiple sclerosis (MS. This is mainly based on “loss-of-function” studies in an animal model for MS, experimental autoimmune encephalomyelitis (EAE, using blocking antibodies against Th2 related cytokines, and knockout mice lacking Th2-related molecules. We tested whether an increase of Th2 responses (“gain-of-function” approach could alter EAE, the approach of novel GATA binding protein 3 (GATA3-transgenic (tg mice that overexpress GATA3, a transcription factor required for Th2 differentiation. In EAE induced with myelin oligodendrocyte glycoprotein (MOG35−55 peptide, GATA3-tg mice had a significantly delayed onset of disease and a less severe maximum clinical score, compared with wild-type C57BL/6 mice. Histologically, GATA3-tg mice had decreased levels of meningitis and demyelination in the spinal cord, and anti-inflammatory cytokine profiles immunologically, however both groups developed similar levels of MOG-specific lymphoproliferative responses. During the early stage, we detected higher levels of interleukin (IL-4 and IL-10, with MOG and mitogen stimulation of regional lymph node cells in GATA3-tg mice. During the late stage, only mitogen stimulation induced higher IL-4 and lower interferon-γ and IL-17 production in GATA3-tg mice. These results suggest that a preexisting bias toward a Th2 immune response may reduce the severity of inflammatory demyelinating diseases, including MS.

Prevalence of Zoonotic Intestinal Helminths of Canids in Mog­han Plain, Northwestern Iran

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M Zare-Bidaki

2010-06-01

Full Text Available Background: The present study was aimed to elucidate the status of intestinal hel­minth infec­tions in canids of Moghan Plain, northwestern Iran.Methods: Eighty-five intestine samples from dead or shot wild canids, 59 fecal samples from sheepdogs and 5 from red foxes were collected from 2006 to 2008 and examined in Parasitology department of Pasteur Institute of Iran.Results: Generally, adult worms, larvae, and eggs of 13 species of various parasitic hel­minths were recovered. Necropsy examinations showed that 96.47% animals harbored at least one helminth species. The prevalence of different species in necropsy were Mesoces­toides sp. 84.7%, Rictolaria spp. 55.3%, Macranthorhynchus hirudinaceus 45.9%, Toxocara canis 43.5%, Toxas­caris spp. 35.3%, Joyeuxiella sp. 34.1%; hook­worms; 22.4%, Taenia spp. 11.8%, Alaria spp. 2.4% and Dipylidium caninum 1.2%. Be­sides, eggs belonging to 10 species of parasitic helminths were identified in 46 fecal sam­ples and generally, 30.9% of samples harbored eggs of at least one helminth species.Conclusion: The high prevalence of various helminth infections among canids in Mog­han plain and contamination of environment by helminths eggs may increase the risk of infection for native peo­ple.

The design of multiplayer online video game systems

Science.gov (United States)

Hsu, Chia-chun A.; Ling, Jim; Li, Qing; Kuo, C.-C. J.

2003-11-01

The distributed Multiplayer Online Game (MOG) system is complex since it involves technologies in computer graphics, multimedia, artificial intelligence, computer networking, embedded systems, etc. Due to the large scope of this problem, the design of MOG systems has not yet been widely addressed in the literatures. In this paper, we review and analyze the current MOG system architecture followed by evaluation. Furthermore, we propose a clustered-server architecture to provide a scalable solution together with the region oriented allocation strategy. Two key issues, i.e. interesting management and synchronization, are discussed in depth. Some preliminary ideas to deal with the identified problems are described.

Proposal for an ecoradiological centre model

International Nuclear Information System (INIS)

Perovic, S.M.; Zunic, Z.; Demajo, M.; Konjevic, N.

1998-01-01

The problem of establishing an optimal Ecoradiological Centre Model is studied in some detail for the town of Kotor which is under the protection of the World Cultural and Natural Heritage. The proposed structure of the Centre is analyzed from the view of Engineering, Education and Scientific parameters. This Model is suitable for implementation as a network Centre Model for the state of Montenegro. Further, the modelling strategy of the ecoradiological condition control of natural, construction, bio and technological systems is elaborated. The proposal includes the ecoradiological monitoring, radioactive and electromagnetic radiation processing and protection for different natural zones as well as their different geostructures, aerial and hydrogeological conditions. The programme also includes all housing objects (hotels, flats, houses, office premises etc.). Here will also be presented the radiation protection and recommendations for the implementation of Title VII of the European Basic Safety Standards Directive (BSS), concerning significant increase in exposure due to natural radiation sources. Also, the proposal of Local Radiation Protection for the town of Kotor is presented. Our proposal for an Ecoradiological Centre Model presented here is in a form of a pilot programme, applicable also for other towns and states. (author)

Proposed Reliability/Cost Model

Science.gov (United States)

Delionback, L. M.

1982-01-01

New technique estimates cost of improvement in reliability for complex system. Model format/approach is dependent upon use of subsystem cost-estimating relationships (CER's) in devising cost-effective policy. Proposed methodology should have application in broad range of engineering management decisions.

A chimeric receptor of the insulin-like growth factor receptor type 1 (IGFR1) and a single chain antibody specific to myelin oligodendrocyte glycoprotein activates the IGF1R signalling cascade in CG4 oligodendrocyte progenitors.

Science.gov (United States)

Annenkov, Alexander; Rigby, Anne; Amor, Sandra; Zhou, Dun; Yousaf, Nasim; Hemmer, Bernhard; Chernajovsky, Yuti

2011-08-01

In order to generate neural stem cells with increased ability to survive after transplantation in brain parenchyma we developed a chimeric receptor (ChR) that binds to myelin oligodendrocyte glycoprotein (MOG) via its ectodomain and activates the insulin-like growth factor receptor type 1 ‎‎(IGF1R) signalling cascade. Activation of this pro-survival pathway in response to ligand broadly available in the brain might increase neuroregenerative potential of transplanted precursors. The ChR was produced by fusing a MOG-specific single ‎chain antibody with the extracellular boundary of the IGF1R transmembrane segment. The ChR is expressed on the cellular surface, predominantly as a monomer, and is not N-glycosylated. To show MOG-dependent functionality of the ChR, neuroblastoma cells B104 expressing this ChR were stimulated with monolayers of cells expressing recombinant MOG. The ChR undergoes MOG-dependent tyrosine phosphorylation and homodimerisation. It promotes insulin and IGF-independent growth of the oligodendrocyte progenitor cell line CG4. The proposed mode of the ChR activation is by MOG-induced dimerisation which promotes kinase domain transphosphorylation, by-passing the requirement of conformation changes known to be important for IGF1R activation. Another ChR, which contains a segment of the β-chain ectodomain, was produced in an attempt to recapitulate some of these conformational changes, but proved non-functional. 2011 Elsevier B.V. All rights reserved.

A Proposed Conceptual Model of Military Medical Readiness

National Research Council Canada - National Science Library

Van Hall, Brian M

2007-01-01

.... The basis for the proposed conceptual model builds on common and accepted latent variable and theoretical modeling techniques proposed by healthcare scholars, organizational theorists, mathematical...

Category-selective attention modulates unconscious processes in the middle occipital gyrus.

Science.gov (United States)

Tu, Shen; Qiu, Jiang; Martens, Ulla; Zhang, Qinglin

2013-06-01

Many studies have revealed the top-down modulation (spatial attention, attentional load, etc.) on unconscious processing. However, there is little research about how category-selective attention could modulate the unconscious processing. In the present study, using functional magnetic resonance imaging (fMRI), the results showed that category-selective attention modulated unconscious face/tool processing in the middle occipital gyrus (MOG). Interestingly, MOG effects were of opposed direction for face and tool processes. During unconscious face processing, activation in MOG decreased under the face-selective attention compared with tool-selective attention. This result was in line with the predictive coding theory. During unconscious tool processing, however, activation in MOG increased under the tool-selective attention compared with face-selective attention. The different effects might be ascribed to an interaction between top-down category-selective processes and bottom-up processes in the partial awareness level as proposed by Kouider, De Gardelle, Sackur, and Dupoux (2010). Specifically, we suppose an "excessive activation" hypothesis. Copyright © 2013 Elsevier Inc. All rights reserved.

The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species.

Directory of Open Access Journals (Sweden)

Alan D Curtis

Full Text Available Atypical models of experimental autoimmune encephalomyelitis (EAE are advantageous in that the heterogeneity of clinical signs appears more reflective of those in multiple sclerosis (MS. Conversely, models of classical EAE feature stereotypic progression of an ascending flaccid paralysis that is not a characteristic of MS. The study of atypical EAE however has been limited due to the relative lack of suitable models that feature reliable disease incidence and severity, excepting mice deficient in gamma-interferon signaling pathways. In this study, atypical EAE was induced in Lewis rats, and a related approach was effective for induction of an unusual neurologic syndrome in a cynomolgus macaque. Lewis rats were immunized with the rat immunoglobulin variable (IgV-related extracellular domain of myelin oligodendrocyte glycoprotein (IgV-MOG in complete Freund's adjuvant (CFA followed by one or more injections of rat IgV-MOG in incomplete Freund's adjuvant (IFA. The resulting disease was marked by torticollis, unilateral rigid paralysis, forelimb weakness, and high titers of anti-MOG antibody against conformational epitopes of MOG, as well as other signs of atypical EAE. A similar strategy elicited a distinct atypical form of EAE in a cynomolgus macaque. By day 36 in the monkey, titers of IgG against conformational epitopes of extracellular MOG were evident, and on day 201, the macaque had an abrupt onset of an unusual form of EAE that included a pronounced arousal-dependent, transient myotonia. The disease persisted for 6-7 weeks and was marked by a gradual, consistent improvement and an eventual full recovery without recurrence. These data indicate that one or more boosters of IgV-MOG in IFA represent a key variable for induction of atypical or unusual forms of EAE in rat and Macaca species. These studies also reveal a close correlation between humoral immunity against conformational epitopes of MOG, extended confluent demyelinating plaques in

The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species.

Science.gov (United States)

Curtis, Alan D; Taslim, Najla; Reece, Shaun P; Grebenciucova, Elena; Ray, Richard H; Rosenbaum, Matthew D; Wardle, Robert L; Van Scott, Michael R; Mannie, Mark D

2014-01-01

Atypical models of experimental autoimmune encephalomyelitis (EAE) are advantageous in that the heterogeneity of clinical signs appears more reflective of those in multiple sclerosis (MS). Conversely, models of classical EAE feature stereotypic progression of an ascending flaccid paralysis that is not a characteristic of MS. The study of atypical EAE however has been limited due to the relative lack of suitable models that feature reliable disease incidence and severity, excepting mice deficient in gamma-interferon signaling pathways. In this study, atypical EAE was induced in Lewis rats, and a related approach was effective for induction of an unusual neurologic syndrome in a cynomolgus macaque. Lewis rats were immunized with the rat immunoglobulin variable (IgV)-related extracellular domain of myelin oligodendrocyte glycoprotein (IgV-MOG) in complete Freund's adjuvant (CFA) followed by one or more injections of rat IgV-MOG in incomplete Freund's adjuvant (IFA). The resulting disease was marked by torticollis, unilateral rigid paralysis, forelimb weakness, and high titers of anti-MOG antibody against conformational epitopes of MOG, as well as other signs of atypical EAE. A similar strategy elicited a distinct atypical form of EAE in a cynomolgus macaque. By day 36 in the monkey, titers of IgG against conformational epitopes of extracellular MOG were evident, and on day 201, the macaque had an abrupt onset of an unusual form of EAE that included a pronounced arousal-dependent, transient myotonia. The disease persisted for 6-7 weeks and was marked by a gradual, consistent improvement and an eventual full recovery without recurrence. These data indicate that one or more boosters of IgV-MOG in IFA represent a key variable for induction of atypical or unusual forms of EAE in rat and Macaca species. These studies also reveal a close correlation between humoral immunity against conformational epitopes of MOG, extended confluent demyelinating plaques in spinal cord and

Adaptive Gradient Multiobjective Particle Swarm Optimization.

Science.gov (United States)

Han, Honggui; Lu, Wei; Zhang, Lu; Qiao, Junfei

2017-10-09

An adaptive gradient multiobjective particle swarm optimization (AGMOPSO) algorithm, based on a multiobjective gradient (stocktickerMOG) method and a self-adaptive flight parameters mechanism, is developed to improve the computation performance in this paper. In this AGMOPSO algorithm, the stocktickerMOG method is devised to update the archive to improve the convergence speed and the local exploitation in the evolutionary process. Meanwhile, the self-adaptive flight parameters mechanism, according to the diversity information of the particles, is then established to balance the convergence and diversity of AGMOPSO. Attributed to the stocktickerMOG method and the self-adaptive flight parameters mechanism, this AGMOPSO algorithm not only has faster convergence speed and higher accuracy, but also its solutions have better diversity. Additionally, the convergence is discussed to confirm the prerequisite of any successful application of AGMOPSO. Finally, with regard to the computation performance, the proposed AGMOPSO algorithm is compared with some other multiobjective particle swarm optimization algorithms and two state-of-the-art multiobjective algorithms. The results demonstrate that the proposed AGMOPSO algorithm can find better spread of solutions and have faster convergence to the true Pareto-optimal front.

Proposed reliability cost model

Science.gov (United States)

Delionback, L. M.

1973-01-01

The research investigations which were involved in the study include: cost analysis/allocation, reliability and product assurance, forecasting methodology, systems analysis, and model-building. This is a classic example of an interdisciplinary problem, since the model-building requirements include the need for understanding and communication between technical disciplines on one hand, and the financial/accounting skill categories on the other. The systems approach is utilized within this context to establish a clearer and more objective relationship between reliability assurance and the subcategories (or subelements) that provide, or reenforce, the reliability assurance for a system. Subcategories are further subdivided as illustrated by a tree diagram. The reliability assurance elements can be seen to be potential alternative strategies, or approaches, depending on the specific goals/objectives of the trade studies. The scope was limited to the establishment of a proposed reliability cost-model format. The model format/approach is dependent upon the use of a series of subsystem-oriented CER's and sometimes possible CTR's, in devising a suitable cost-effective policy.

Type I Shell Galaxies as a Test of Gravity Models

Energy Technology Data Exchange (ETDEWEB)

Vakili, Hajar; Rahvar, Sohrab [Department of Physics, Sharif University of Technology, P.O. Box 11365-9161, Tehran (Iran, Islamic Republic of); Kroupa, Pavel, E-mail: vakili@physics.sharif.edu [Helmholtz-Institut für Strahlen-und Kernphysik, Universität Bonn, Nussallee 14-16, D-53115 Bonn (Germany)

2017-10-10

Shell galaxies are understood to form through the collision of a dwarf galaxy with an elliptical galaxy. Shell structures and kinematics have been noted to be independent tools to measure the gravitational potential of the shell galaxies. We compare theoretically the formation of shells in Type I shell galaxies in different gravity theories in this work because this is so far missing in the literature. We include Newtonian plus dark halo gravity, and two non-Newtonian gravity models, MOG and MOND, in identical initial systems. We investigate the effect of dynamical friction, which by slowing down the dwarf galaxy in the dark halo models limits the range of shell radii to low values. Under the same initial conditions, shells appear on a shorter timescale and over a smaller range of distances in the presence of dark matter than in the corresponding non-Newtonian gravity models. If galaxies are embedded in a dark matter halo, then the merging time may be too rapid to allow multi-generation shell formation as required by observed systems because of the large dynamical friction effect. Starting from the same initial state, the observation of small bright shells in the dark halo model should be accompanied by large faint ones, while for the case of MOG, the next shell generation patterns iterate with a specific time delay. The first shell generation pattern shows a degeneracy with the age of the shells and in different theories, but the relative distance of the shells and the shell expansion velocity can break this degeneracy.

Stohastički model prognoze potražnje rezervnih delova

OpenAIRE

Milojević S. Ivan; Guberinić V. Rade

2012-01-01

U ovom radu dat je stohastički model prognoze potražnje rezervnih delova. Model koji je dat izabran je po sledećim kriterijumima: da može biti primenjen, prema nameni prognoze potražnje rezervnih delova i da se ne nalazi u osnovnoj udžbeničkoj literaturi. Da bi se mogli izdvojiti, doraditi i razviti, novi modeli i metode prognoze potražnje rezervnih delova, nužno je sagledati sve ono što na neki način utiče na potražnju. Izdvojeni su uticajni faktori na potražnju rezervnih d...

A Proposal for a Flexible Trend Specification in DSGE Models

Directory of Open Access Journals (Sweden)

Slanicay Martin

2016-06-01

Full Text Available In this paper I propose a flexible trend specification for estimating DSGE models on log differences. I demonstrate this flexible trend specification on a New Keynesian DSGE model of two economies, which I consequently estimate on data from the Czech economy and the euro area, using Bayesian techniques. The advantage of the trend specification proposed is that the trend component and the cyclical component are modelled jointly in a single model. The proposed trend specification is flexible in the sense that smoothness of the trend can be easily modified by different calibration of some of the trend parameters. The results suggest that this method is capable of finding a very reasonable trend in the data. Moreover, comparison of forecast performance reveals that the proposed specification offers more reliable forecasts than the original variant of the model.

A B Cell-Driven Autoimmune Pathway Leading to Pathological Hallmarks of Progressive Multiple Sclerosis in the Marmoset Experimental Autoimmune Encephalomyelitis Model

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Bert A. ’t Hart

2017-07-01

Full Text Available The absence of pathological hallmarks of progressive multiple sclerosis (MS in commonly used rodent models of experimental autoimmune encephalomyelitis (EAE hinders the development of adequate treatments for progressive disease. Work reviewed here shows that such hallmarks are present in the EAE model in marmoset monkeys (Callithrix jacchus. The minimal requirement for induction of progressive MS pathology is immunization with a synthetic peptide representing residues 34–56 from human myelin oligodendrocyte glycoprotein (MOG formulated with a mineral oil [incomplete Freund’s adjuvant (IFA]. Pathological aspects include demyelination of cortical gray matter with microglia activation, oxidative stress, and redistribution of iron. When the peptide is formulated in complete Freund’s adjuvant, which contains mycobacteria that relay strong activation signals to myeloid cells, oxidative damage pathways are strongly boosted leading to more intensive pathology. The proven absence of immune potentiating danger signals in the MOG34–56/IFA formulation implies that a narrow population of antigen-experienced T cells present in the monkey’s immune repertoire is activated. This novel pathway involves the interplay of lymphocryptovirus-infected B cells with MHC class Ib/Caja-E restricted CD8+ CD56+ cytotoxic T lymphocytes.

A proposed best practice model validation framework for banks

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Pieter J. (Riaan de Jongh

2017-06-01

Full Text Available Background: With the increasing use of complex quantitative models in applications throughout the financial world, model risk has become a major concern. The credit crisis of 2008–2009 provoked added concern about the use of models in finance. Measuring and managing model risk has subsequently come under scrutiny from regulators, supervisors, banks and other financial institutions. Regulatory guidance indicates that meticulous monitoring of all phases of model development and implementation is required to mitigate this risk. Considerable resources must be mobilised for this purpose. The exercise must embrace model development, assembly, implementation, validation and effective governance. Setting: Model validation practices are generally patchy, disparate and sometimes contradictory, and although the Basel Accord and some regulatory authorities have attempted to establish guiding principles, no definite set of global standards exists. Aim: Assessing the available literature for the best validation practices. Methods: This comprehensive literature study provided a background to the complexities of effective model management and focussed on model validation as a component of model risk management. Results: We propose a coherent ‘best practice’ framework for model validation. Scorecard tools are also presented to evaluate if the proposed best practice model validation framework has been adequately assembled and implemented. Conclusion: The proposed best practice model validation framework is designed to assist firms in the construction of an effective, robust and fully compliant model validation programme and comprises three principal elements: model validation governance, policy and process.

A proposed general model of information behaviour.

Directory of Open Access Journals (Sweden)

2003-01-01

Full Text Available Presents a critical description of Wilson's (1996 global model of information behaviour and proposes major modification on the basis of research into information behaviour of managers, conducted in Poland. The theoretical analysis and research results suggest that Wilson's model has certain imperfections, both in its conceptual content, and in graphical presentation. The model, for example, cannot be used to describe managers' information behaviour, since managers basically are not the end users of external from organization or computerized information services, and they acquire information mainly through various intermediaries. Therefore, the model cannot be considered as a general model, applicable to every category of information users. The proposed new model encompasses the main concepts of Wilson's model, such as: person-in-context, three categories of intervening variables (individual, social and environmental, activating mechanisms, cyclic character of information behaviours, and the adoption of a multidisciplinary approach to explain them. However, the new model introduces several changes. They include: 1. identification of 'context' with the intervening variables; 2. immersion of the chain of information behaviour in the 'context', to indicate that the context variables influence behaviour at all stages of the process (identification of needs, looking for information, processing and using it; 3. stress is put on the fact that the activating mechanisms also can occur at all stages of the information acquisition process; 4. introduction of two basic strategies of looking for information: personally and/or using various intermediaries.

A proposed wind shift model for the German reactor safety study

International Nuclear Information System (INIS)

Aldrich, D.C.; Bayer, A.; Schueckler, M.

1979-04-01

To account for hourly wind direction changes, a wind shift model has been proposed. Using hourly recorded wind speed and direction data, the model modifies the angular distribution of radionuclide concentrations calculated by a straightline model, and is intended to better represent the concentrations in areas close to the reactor where potential doses might exceed the threshold level for early fatalities. 115 weather sequences were used, both with and without the proposed wind shift model, to calculate probability distributions for early fatalities. The use of the proposed model results in a reduction of the mean and peak values of that distribution by 36% and 29%, respectively. (orig./HP) [de

Gamification in online education: proposal for a participatory learning model

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Fabiana Bigão Silva

2017-09-01

Full Text Available Empirical studies have suggested limitations on the form of application of gamification mechanics in the context of online education. These mechanics have been applied without reference to a theoretical model dedicated to this type of education. The objective of the paper is to propose a model for a gamified platform for online education that contributes to a more participatory learning, taking into account the different student profiles. Based on literature review about approaches to gamification systems design, a set of steps was followed in order to develop a generic model for a framework dedicated to online education. The model proposed is based on the Educational Gamification Design Principles proposed by Dicheva et al. (2015. The model may contribute to the promotion of participatory learning, taking into account the different student profiles. The results of such evaluation will be published in the future.

A proposed residual stress model for oblique turning

International Nuclear Information System (INIS)

Elkhabeery, M. M.

2001-01-01

A proposed mathematical model is presented for predicting the residual stresses caused by turning. Effects of change in tool free length, cutting speed, feed rate, and the tensile strength of work piece material on the maximum residual stress are investigated. The residual stress distribution in the surface region due to turning under unlubricated condition is determined using a deflection etching technique. To reduce the number of experiments required and build the mathematical model for these variables, Response Surface Methodology (RSM) is used. In addition, variance analysis and an experimental check are conducted to determine the prominent parameters and the adequacy of the model. The results show that the tensile stress of the work piece material, cutting speed, and feed rate have significant effects on the maximum residual stresses. The proposed model, that offering good correlation between the experimental and predicted results, is useful in selecting suitable cutting parameters for the machining of different materials. (author)

A proposed experiment on ball lightning model

International Nuclear Information System (INIS)

Ignatovich, Vladimir K.; Ignatovich, Filipp V.

2011-01-01

Highlights: → We propose to put a glass sphere inside an excited gas. → Then to put a light ray inside the glass in a whispering gallery mode. → If the light is resonant to gas excitation, it will be amplified at every reflection. → In ms time the light in the glass will be amplified, and will melt the glass. → A liquid shell kept integer by electrostriction forces is the ball lightning model. -- Abstract: We propose an experiment for strong light amplification at multiple total reflections from active gaseous media.

Regulatory Lymphocytes Are Key Factors in MHC-Independent Resistance to EAE

Science.gov (United States)

Marín, Nieves; Mecha, Miriam; Espejo, Carmen; Mestre, Leyre; Eixarch, Herena; Montalban, Xavier; Álvarez-Cermeño, José C.; Guaza, Carmen; Villar, Luisa M.

2014-01-01

Background and Objectives. Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE), an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. We aimed to explore MHC-independent mechanisms inducing resistance to EAE. Methods. For EAE induction, female C57BL/6 (susceptible strain) and CD1 (resistant outbred strain showing heterogeneous MHC antigens) mice were immunized with the 35–55 peptide of myelin oligodendrocyte glycoprotein (MOG35−55). We studied T cell proliferation, regulatory and effector cell subpopulations, intracellular and serum cytokine patterns, and titers of anti-MOG serum antibodies. Results. Upon immunization with MOG35−55, T lymphocytes from susceptible mice but not that of resistant strain were capable of proliferating when stimulated with MOG35−55. Accordingly, resistant mice experienced a rise in regulatory B cells (P = 0.001) and, to a lower extent, in regulatory T cells (P = 0.02) compared with C57BL/6 susceptible mice. As a consequence, MOG35−55-immunized C57BL/6 mice showed higher percentages of CD4+ T cells producing both IFN-gamma (P = 0.02) and IL-17 (P = 0.009) and higher serum levels of IL-17 (P = 0.04) than resistant mice. Conclusions. Expansion of regulatory B and T cells contributes to the induction of resistance to EAE by an MHC-independent mechanism. PMID:24868560

Regulatory Lymphocytes Are Key Factors in MHC-Independent Resistance to EAE

Directory of Open Access Journals (Sweden)

Nieves Marín

2014-01-01

Full Text Available Background and Objectives. Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE, an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. We aimed to explore MHC-independent mechanisms inducing resistance to EAE. Methods. For EAE induction, female C57BL/6 (susceptible strain and CD1 (resistant outbred strain showing heterogeneous MHC antigens mice were immunized with the 35–55 peptide of myelin oligodendrocyte glycoprotein (MOG35−55. We studied T cell proliferation, regulatory and effector cell subpopulations, intracellular and serum cytokine patterns, and titers of anti-MOG serum antibodies. Results. Upon immunization with MOG35−55, T lymphocytes from susceptible mice but not that of resistant strain were capable of proliferating when stimulated with MOG35−55. Accordingly, resistant mice experienced a rise in regulatory B cells (P=0.001 and, to a lower extent, in regulatory T cells (P=0.02 compared with C57BL/6 susceptible mice. As a consequence, MOG35−55-immunized C57BL/6 mice showed higher percentages of CD4+ T cells producing both IFN-gamma (P=0.02 and IL-17 (P=0.009 and higher serum levels of IL-17 (P=0.04 than resistant mice. Conclusions. Expansion of regulatory B and T cells contributes to the induction of resistance to EAE by an MHC-independent mechanism.

A Proposed Conceptual Model of Military Medical Readiness

National Research Council Canada - National Science Library

Van Hall, Brian M

2007-01-01

.... The purpose of this research is to consolidate existing literature on the latent variable of medical readiness, and to propose a composite theoretical model of medical readiness that may provide...

Modeling Instruction of David Hestenes: a proposal of thematic modeling cycle and discussion of scientific literacy

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Ednilson Sergio Ramalho de Souza

2016-07-01

Full Text Available The pedagogical work with mathematical modeling assumes investigate situations of reality. However, mental models formed from the contact with the experiential world are generally incompatible with the conceptual models. So David Hestenes supports the view that one of the biggest challenges of teaching and learning in science and mathematics is to coordinate conceptual models with mental models, which led to the elaboration of a didactic in mathematical modeling: Modeling Instruction. Our goal is to present a proposal for thematic modeling cycle drawn up in hestenesianos assumptions and discuss possibilities for scientific literacy. The main question was to know how to emerge indicators for scientific literacy for the proposed cycle. This is a bibliographic research in order to identify the available literature contributions on the subject and raise the possibility and challenges for the brazilian teaching science and mathematics. Preliminary results indicate that the proposed modeling cycle can develop indicators for scientific literacy of different natures.

A New Proposed Cost Model for List Accessing Problem using Buffering

OpenAIRE

Mohanty, Rakesh; Bhoi, Seetaya; Tripathy, Sasmita

2011-01-01

There are many existing well known cost models for the list accessing problem. The standard cost model developed by Sleator and Tarjan is most widely used. In this paper, we have made a comprehensive study of the existing cost models and proposed a new cost model for the list accessing problem. In our proposed cost model, for calculating the processing cost of request sequence using a singly linked list, we consider the access cost, matching cost and replacement cost. The cost of processing a...

Tacit knowledge in academia: a proposed model and measurement scale.

Science.gov (United States)

Leonard, Nancy; Insch, Gary S

2005-11-01

The authors propose a multidimensional model of tacit knowledge and develop a measure of tacit knowledge in academia. They discuss the theory and extant literature on tacit knowledge and propose a 6-factor model. Experiment 1 is a replication of a recent study of academic tacit knowledge using the scale developed and administered at an Israeli university (A. Somech & R. Bogler, 1999). The results of the replication differed from those found in the original study. For Experiment 2, the authors developed a domain-specific measure of academic tacit knowledge, the Academic Tacit Knowledge Scale (ATKS), and used this measure to explore the multidimensionality of tacit knowledge proposed in the model. The results of an exploratory factor analysis (n=142) followed by a confirmatory factor analysis (n=286) are reported. The sample for both experiments was 428 undergraduate students enrolled at a large public university in the eastern United States. Results indicated that a 5-factor model of academic tacit knowledge provided a strong fit for the data.

Serological markers associated with neuromyelitis optica spectrum disorders in South India

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Lekha Pandit

2016-01-01

Full Text Available Background: Neuromyelitis optica spectrum disorders (NMOSDs represent 20% of all demyelinating disorders in South India. No studies have determined the seroprevalence to both antibodies against aquaporin-4FNx01 and antimyelin oligodendrocyte glycoprotein antibody (anti-MOG+ in this population. Objective: To identify and characterize seropositive patients for anti-aquaporin-4 antibody (anti-AQP4+ and anti-MOG+ in South India. Materials and Methods: We included 125 consecutive patients (15 children who were serologically characterized using live transfected cells to human M23-AQP4 or full-length MOG. Results: Among a total of 125 patients, 30.4% of patients were anti-AQP4+, 20% were anti-MOG+, and 49.6% were seronegative. No patient was positive for both. Anti-MOG+ patients represented 28.7% (25/87 of seronegative NMOSD. In comparison to anti-AQP4+ patients, anti-MOG+ patients were commonly male, had less frequent attacks and milder disability on expanded disability status score scale. Seronegative patients were also predominantly male, 36% (9/25 had monophasic longitudinally extensive transverse myelitis and disability was comparable with anti-AQP4+ patients. Lumbar cord involvement was common in anti-MOG+ and seronegatives, whereas anti-AQP4+ patients had more cervical lesions. Conclusion: Anti-AQP4+/anti-MOG + patients accounted for nearly half of the patients suspected of having NMOSD in South India, indicating that antibody testing may be useful on the management of subgroups with different prognosis.

A Proposed Systems Model for Socializing the Graduate Writer

Science.gov (United States)

Jones, David R.

2018-01-01

Although researchers chorus the need to support graduate students toward higher levels of writing proficiency, their findings lack a holistic model for doing so. A model emerges upon scrutiny of the factors that have been implicated in supporting writing proficiency. In the proposed model, a socialization theory fits as a proximal process into the…

The different clinical effects of anti-BLyS, anti-APRIL and anti-CD20 antibodies point at a critical pathogenic role of γ-herpesvirus infected B cells in the marmoset EAE model.

Science.gov (United States)

Anwar Jagessar, S; Fagrouch, Zahra; Heijmans, Nicole; Bauer, Jan; Laman, Jon D; Oh, Luke; Migone, Thi; Verschoor, Ernst J; 't Hart, Bert A

2013-06-01

The robust and rapid clinical effect of depleting anti-CD20 monoclonal antibodies (mAb) in multiple sclerosis (MS) demonstrates a critical pathogenic contribution of B cells. The clinical effect of anti-CD20 mAb has been replicated in a relevant preclinical MS model, experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys (Callithrix jacchus). By contrast, treatment with mAbs against two essential cytokines in B cell activation growth and survival, i.e. BlyS/BAFF and APRIL, was only partially effective. All three mAbs induced depletion of CD20+ B cells from the circulation, albeit with different kinetics and based on distinct mechanisms of action. In the current study we analyzed whether the different clinical effect of anti-CD20 mAb or the anti-BLyS and anti-APRIL mAbs is due to different depletion of B cells infected with the EBV of marmosets, CalHV3. Employing a novel PCR-based assay, half of the colony of group-housed marmosets was tested positive for CalHV3 DNA in secondary lymphoid organs. The same prevalence was observed in placebo-treated monkeys. In marmosets treated with anti-CD20 mAb the load of CalHV3 DNA in lymphoid organs was substantially reduced, while this was not observed in the monkeys treated with anti-BLyS or anti-APRIL mAbs. To examine the pathogenic role of virus-transformed B cells, we infused EBV-transformed B lymphoblastic cell (BLC) lines presenting the immunodominant MOG34-56 peptide. We observed in the recipients of MOG34-56 pulsed BLC, but not in their fraternal siblings infused with non-pulsed BLC, activation of anti-MOG34-56 T cells and meningeal inflammation. Collectively, the data show that among CD20+ B cells, the herpesvirus-transformed subset has a particularly important pathogenic role in the marmoset EAE model.

Main features of the proposed NCRP respiratory tract model

International Nuclear Information System (INIS)

Phalen, R.F.; Fisher, G.L.; Moss, O.R.; Schlesinger, R.B.; Swift, D.L.

1991-01-01

The proposed NCRP respiratory tract dosimetry model regions include the naso-oro-pharyngo-laryngeal (NOPL), the tracheobronchial (TB), the pulmonary (P), and the lymph nodes (LN). Input aerosol concentrations are derived from a consideration of particle-size-dependent inspirability. Particle deposition in the respiratory tract is modelled using the mechanisms of inertial impaction, sedimentation and diffusion. The rates of absorption of particles, and transport to the blood, have been derived from clearance data from people and laboratory animals. The effect of body growth on particle deposition is considered. Particle clearance rates are assumed to be independent of age. The proposed respiratory tract model differs significantly from the 1966 Task Group Model in that (1) inspirability is considered; (2) new sub-regions of the respiratory tract are considered; (3) absorption of materials by the blood is treated in a more sophisticated fashion; and (4) body size (and thus age) is taken into account. (author)

Modified Gravity and its test on galaxy clusters

Science.gov (United States)

Nieuwenhuizen, Theodorus M.; Morandi, Andrea; Limousin, Marceau

2018-05-01

The MOdified Gravity (MOG) theory of J. Moffat assumes a massive vector particle which causes a repulsive contribution to the tensor gravitation. For the galaxy cluster A1689 new data for the X-ray gas and the strong lensing properties are presented. Fits to MOG are possible by adjusting the galaxy density profile. However, this appears to work as an effective dark matter component, posing a serious problem for MOG. New gas and strong lensing data for the cluster A1835 support these conclusions and point at a tendency of the gas alone to overestimate the lensing effects in MOG theory.

An Analytical Analysis of Hydraulic Jump in Triangular Channel: A Proposed Model

Science.gov (United States)

Khan, S. A.

2013-05-01

The paper presents the theoretical study of hydraulic jump in triangular channel section. Presuming the jump as one dimensional free shear layer with hydrostatic pressure distribution across it and using momentum equation, specific force equation is obtained. Using the specific force equation and eddy viscosity equation, analytical models for sequent depth, dimensionless profile, turbulent shear stress distribution and energy loss for various initial Froude numbers have been obtained. The proposed models for sequent depth and energy loss are also compared with the other developed models. The proposed energy loss model also provides the energy loss at any point along the jump, while this provision is not available in the models of other investigators. Newton-Raphson and Runge-Kutta methods are used for the solution of the proposed model. The outcome of this study can be used in the design of stilling basin floor and side walls on permeable foundations.

Proposal of a new biokinetic model for niobium

International Nuclear Information System (INIS)

Oliveira, Roges

2006-01-01

There are two niobium isotopes generated in nuclear power plants: 95 Nb and 94 Nb. Workers and members of the public are subjects to intake these radionuclides in accident situation. For dose calculation purpose, it is very important to develop a model that describes in a more realistic way the kinetics of niobium inside of the human body. Presently the model adopted by ICRP (ICRP, 1989) is based on animal studies and describes the behavior of niobium in human being in a simple manner. The new model proposal describes the kinetics of the niobium from the intake into the blood until the excretion, doing this in a more realistic form and considering not only data from animals but data from human beings as well. For this objective, a workers group of a niobium extraction and processing industry exposed to stable niobium (93 Nb) in oxide insoluble form with associated uranium, was monitored for uranium and niobium determination in urinary and fecal excretion, by mass spectrometry. Based in the ratios of the niobium concentration in urinary and faecal excretion of this workers and animal data study, a new biokinetic model for niobium was proposed, with the followings modifications relative to ICRP model: a new compartment that represents muscular tissue; the fractions which are deposited into the compartment are modified; a third component in the retention equation of the bone tissue; introduction of recirculation between organs and blood. The new model was applied for a case of accidental intake and described adequately the experimental data

A Modified Microfinance Model Proposed for the United States

Directory of Open Access Journals (Sweden)

Eldon H Bernstein

2014-07-01

While the goal in the traditional model in developing markets is the elimination of poverty, we show how those critical conditions help to explain the lack of success in the United States.  We propose a modified model whose goal is the creation of an entrepreneurial venture or improving the performance of an existing small enterprise.

Linear regression crash prediction models : issues and proposed solutions.

Science.gov (United States)

2010-05-01

The paper develops a linear regression model approach that can be applied to : crash data to predict vehicle crashes. The proposed approach involves novice data aggregation : to satisfy linear regression assumptions; namely error structure normality ...

A Proposed Model of Jazz Theory Knowledge Acquisition

Science.gov (United States)

Ciorba, Charles R.; Russell, Brian E.

2014-01-01

The purpose of this study was to test a hypothesized model that proposes a causal relationship between motivation and academic achievement on the acquisition of jazz theory knowledge. A reliability analysis of the latent variables ranged from 0.92 to 0.94. Confirmatory factor analyses of the motivation (standardized root mean square residual…

Rational design and synthesis of altered peptide ligands based on human myelin oligodendrocyte glycoprotein 35-55 epitope: inhibition of chronic experimental autoimmune encephalomyelitis in mice.

Science.gov (United States)

Tselios, Theodore; Aggelidakis, Mihalis; Tapeinou, Anthi; Tseveleki, Vivian; Kanistras, Ioannis; Gatos, Dimitrios; Matsoukas, John

2014-11-04

Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease of the central nervous system and is an animal model of multiple sclerosis (MS). Although the etiology of MS remains unclear, there is evidence T-cell recognition of immunodominant epitopes of myelin proteins, such as the 35-55 epitope of myelin oligodendrocyte glycoprotein (MOG), plays a pathogenic role in the induction of chronic EAE. Cyclization of peptides is of great interest since the limited stability of linear peptides restricts their potential use as therapeutic agents. Herein, we have designed and synthesized a number of linear and cyclic peptides by mutating crucial T cell receptor (TCR) contact residues of the human MOG35-55 epitope. In particular, we have designed and synthesized cyclic altered peptide ligands (APLs) by mutating Arg41 with Ala or Arg41 and Arg46 with Ala. The peptides were synthesized in solid phase on 2-chlorotrityl chloride resin (CLTR-Cl) using the Fmoc/t-Bu methodology. The purity of final products was verified by RP-HPLC and their identification was achieved by ESI-MS. It was found that the substitutions of Arg at positions 41 and 46 with Ala results in peptide analogues that reduce the severity of MOG-induced EAE clinical symptoms in C57BL/6 mice when co-administered with mouse MOG35-55 peptide at the time of immunization.

IMPROVING THE INTEROPERABILITY OF DISASTER MODELS: A CASE STUDY OF PROPOSING FIREML FOR FOREST FIRE MODEL

Directory of Open Access Journals (Sweden)

W. Jiang

2018-04-01

Full Text Available This paper presents a new standardized data format named Fire Markup Language (FireML, extended by the Geography Markup Language (GML of OGC, to elaborate upon the fire hazard model. The proposed FireML is able to standardize the input and output documents of a fire model for effectively communicating with different disaster management systems to ensure a good interoperability. To demonstrate the usage of FireML and testify its feasibility, an adopted forest fire spread model being compatible with FireML is described. And a 3DGIS disaster management system is developed to simulate the dynamic procedure of forest fire spread with the defined FireML documents. The proposed approach will enlighten ones who work on other disaster models' standardization work.

Improving the Interoperability of Disaster Models: a Case Study of Proposing Fireml for Forest Fire Model

Science.gov (United States)

Jiang, W.; Wang, F.; Meng, Q.; Li, Z.; Liu, B.; Zheng, X.

2018-04-01

This paper presents a new standardized data format named Fire Markup Language (FireML), extended by the Geography Markup Language (GML) of OGC, to elaborate upon the fire hazard model. The proposed FireML is able to standardize the input and output documents of a fire model for effectively communicating with different disaster management systems to ensure a good interoperability. To demonstrate the usage of FireML and testify its feasibility, an adopted forest fire spread model being compatible with FireML is described. And a 3DGIS disaster management system is developed to simulate the dynamic procedure of forest fire spread with the defined FireML documents. The proposed approach will enlighten ones who work on other disaster models' standardization work.

Proposal for product development model focused on ce certification methodology

Directory of Open Access Journals (Sweden)

Nathalia Marcia Goulart Pinheiro

2015-09-01

Full Text Available This paper presents a critical analysis comparing 21 product development models in order to identify whether these structures meet the demands Product Certification of the European Community (CE. Furthermore, it presents a product development model, comprising the steps in the models analyzed, including improvements in activities for referred product certification. The proposed improvements are justified by the growing quest for the internationalization of products and processes within companies.

The 'OMITRON' and 'MODEL OMITRON' proposed experiments

International Nuclear Information System (INIS)

Sestero, A.

1997-12-01

In the present paper the main features of the OMITRON and MODEL OMITRON proposed high field tokamaks are illustrated. Of the two, OMITRON is an ambitious experiment, aimed at attaining plasma burning conditions. its key physics issues are discussed, and a comparison is carried out with corresponding physics features in ignition experiments such as IGNITOR and ITER. Chief asset and chief challenge - in both OMITRON and MODEL OMITRON is the conspicuous 20 Tesla toroidal field value on the plasma axis. The advanced features of engineering which consent such a reward in terms of toroidal magnet performance are discussed in convenient depth and detail. As for the small, propaedeutic device MODEL OMITRON among its goals one must rank the purpose of testing key engineering issues in vivo, which are vital for the larger and more expensive parent device. Besides that, however - as indicated by ad hoc performed scoping studies - the smaller machine is found capable also of a number of quite interesting physics investigations in its own right

Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis.

Science.gov (United States)

Nakajima, Hideki; Motomura, Masakatsu; Tanaka, Keiko; Fujikawa, Azusa; Nakata, Ruka; Maeda, Yasuhiro; Shima, Tomoaki; Mukaino, Akihiro; Yoshimura, Shunsuke; Miyazaki, Teiichiro; Shiraishi, Hirokazu; Kawakami, Atsushi; Tsujino, Akira

2015-04-02

To investigate the differences of clinical features, cerebrospinal fluid (CSF), MRI findings and response to steroid therapies between patients with optic neuritis (ON) who have myelin oligodendrocyte glycoprotein (MOG) antibodies and those who have seronegative ON. We recruited participants in the department of neurology and ophthalmology in our hospital in Japan. We retrospectively evaluated the clinical features and response to steroid therapies of patients with ON. Sera from patients were tested for antibodies to MOG and aquaporin-4 (AQP4) with a cell-based assay. Between April 2009 and March 2014, we enrolled serial 57 patients with ON (27 males, 30 females; age range 16-84 years) who ophthalmologists had diagnosed as having or suspected to have ON with acute visual impairment and declined critical flicker frequency, abnormal findings of brain MRI, optical coherence tomography and fluorescein fundus angiography at their onset or recurrence. We excluded those patients who fulfilled the diagnostic criteria of neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD), MS McDonald's criteria, and so on. Finally we defined 29 patients with idiopathic ON (14 males, 15 females, age range 16-84 years). 27.6% (8/29) were positive for MOG antibodies and 3.4% (1/29) were positive for AQP4. Among the eight patients with MOG antibodies, five had optic pain (p=0.001) and three had prodromal infection (p=0.179). Three of the eight MOG-positive patients showed significantly high CSF levels of myelin basic protein (p=0.021) and none were positive for oligoclonal band in CSF. On MRIs, seven MOG-positive patients showed high signal intensity on optic nerve, three had a cerebral lesion and one had a spinal cord lesion. Seven of the eight MOG-positive patients had a good response to steroid therapy. Although not proving primary pathogenicity of anti-MOG antibodies, the present results indicate that the measurement of MOG antibodies is useful in diagnosing and treating ON

[Impact of small-area context on health: proposing a conceptual model].

Science.gov (United States)

Voigtländer, S; Mielck, A; Razum, O

2012-11-01

Recent empirical studies stress the impact of features related to the small-area context on individual health. However, so far there exists no standard explanatory model that integrates the different kinds of such features and that conceptualises their relation to individual characteristics of social inequality. A review of theoretical publications on the relationship between social position and health as well as existing conceptual models for the impact of features related to the small-area context on health was undertaken. In the present article we propose a conceptual model for the health impact of the small-area context. This model conceptualises the location of residence as one dimension of social inequality that affects health through the resources as well as stressors which are inherent in the small-area context. The proposed conceptual model offers an orientation for future empirical studies and can serve as a basis for further discussions concerning the health relevance of the small-area context. © Georg Thieme Verlag KG Stuttgart · New York.

Non-monotonic reasoning in conceptual modeling and ontology design: A proposal

CSIR Research Space (South Africa)

Casini, G

2013-06-01

Full Text Available -1 2nd International Workshop on Ontologies and Conceptual Modeling (Onto.Com 2013), Valencia, Spain, 17-21 June 2013 Non-monotonic reasoning in conceptual modeling and ontology design: A proposal Giovanni Casini1 and Alessandro Mosca2 1...

Metal-organic gel enhanced fluorescence anisotropy for sensitive detection of prostate specific antigen

Science.gov (United States)

Zhao, Ting Ting; Peng, Zhe Wei; Yuan, Dan; Zhen, Shu Jun; Huang, Cheng Zhi; Li, Yuan Fang

2018-03-01

In this contribution, we demonstrated that Cu-based metal-organic gel (Cu-MOG) was able to serve as a novel amplification platform for fluorescence anisotropy (FA) assay for the first time, which was confirmed by the sensitive detection of a common cancer biomarker, prostate specific antigen (PSA). The dye-labeled probe aptamer (PA) product was adsorbed onto the benzimidazole derivative-containing Cu-MOG via electrostatic incorporation and strong π-π stacking interactions, which significantly increased the FA value due to the enlargement of the molecular volume of the PA/Cu-MOG complex. With the introduction of target PSA, the FA value was obviously decreased on account of the specific recognition between PSA and PA which resulted in the detachment of PA from the surface of MOG. The linear range was from 0.5-8 ng/mL, with a detection limit of 0.33 ng/mL. Our work has thus helped to demonstrate promising application of MOG material in the fields of biomolecules analysis and disease diagnosis.

Fatty Acids Dietary Supplements Exert Anti-Inflammatory Action and Limit Ganglion Cell Degeneration in the Retina of the EAE Mouse Model of Multiple Sclerosis

Science.gov (United States)

Locri, Filippo; Amato, Rosario; Marsili, Stefania; Rusciano, Dario; Bagnoli, Paola

2018-01-01

Optic neuritis is an acute inflammatory demyelinating disorder of the optic nerve (ON) and is an initial symptom of multiple sclerosis (MS). Optic neuritis is characterized by ON degeneration and retinal ganglion cell (RGC) loss that contributes to permanent visual disability and lacks a reliable treatment. Here, we used the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, a well-established model also for optic neuritis. In this model, C57BL6 mice, intraperitoneally injected with a fragment of the myelin oligodendrocyte glycoprotein (MOG), were found to develop inflammation, Müller cell gliosis, and infiltration of macrophages with increased production of oncomodulin (OCM), a calcium binding protein that acts as an atypical trophic factor for neurons enabling RGC axon regeneration. Immunolabeling of retinal whole mounts with a Brn3a antibody demonstrated drastic RGC loss. Dietary supplementation with Neuro-FAG (nFAG®), a balanced mixture of fatty acids (FAs), counteracted inflammatory and gliotic processes in the retina. In contrast, infiltration of macrophages and their production of OCM remained at elevated levels thus eventually preserving OCM trophic activity. In addition, the diet supplement with nFAG exerted a neuroprotective effect preventing MOG-induced RGC death. In conclusion, these data suggest that the balanced mixture of FAs may represent a useful form of diet supplementation to limit inflammatory events and death of RGCs associated to optic neuritis. This would occur without affecting macrophage infiltration and the release of OCM thus favoring the maintenance of OCM neuroprotective role. PMID:29517994

Fatty Acids Dietary Supplements Exert Anti-Inflammatory Action and Limit Ganglion Cell Degeneration in the Retina of the EAE Mouse Model of Multiple Sclerosis

Directory of Open Access Journals (Sweden)

Massimo Dal Monte

2018-03-01

Full Text Available Optic neuritis is an acute inflammatory demyelinating disorder of the optic nerve (ON and is an initial symptom of multiple sclerosis (MS. Optic neuritis is characterized by ON degeneration and retinal ganglion cell (RGC loss that contributes to permanent visual disability and lacks a reliable treatment. Here, we used the experimental autoimmune encephalomyelitis (EAE mouse model of MS, a well-established model also for optic neuritis. In this model, C57BL6 mice, intraperitoneally injected with a fragment of the myelin oligodendrocyte glycoprotein (MOG, were found to develop inflammation, Müller cell gliosis, and infiltration of macrophages with increased production of oncomodulin (OCM, a calcium binding protein that acts as an atypical trophic factor for neurons enabling RGC axon regeneration. Immunolabeling of retinal whole mounts with a Brn3a antibody demonstrated drastic RGC loss. Dietary supplementation with Neuro-FAG (nFAG®, a balanced mixture of fatty acids (FAs, counteracted inflammatory and gliotic processes in the retina. In contrast, infiltration of macrophages and their production of OCM remained at elevated levels thus eventually preserving OCM trophic activity. In addition, the diet supplement with nFAG exerted a neuroprotective effect preventing MOG-induced RGC death. In conclusion, these data suggest that the balanced mixture of FAs may represent a useful form of diet supplementation to limit inflammatory events and death of RGCs associated to optic neuritis. This would occur without affecting macrophage infiltration and the release of OCM thus favoring the maintenance of OCM neuroprotective role.

European Model Company Act jako nowy instrument harmonizacji europejskiego prawa spółek

OpenAIRE

Możdżeń, Kamila

2016-01-01

Przedmiotem żywej dyskusji w dziedzinie harmonizacji europejskiego prawa spółek stał się ostatnio przełomowy szkic europejskiej ustawy modelowej o spółkach - European Model Company Act (EMCA), który po kilku latach prac najwybitniejszych ekspertów z całej Europy ujrzał światło dzienne. Modelowy europejski kodeks spółek handlowych, który państwa członkowskie będą mogły dobrowolnie implementować, ma pełnić rolę obiecującego dopełnienia dotychczasowych instrumentów harmonizacyjnych oraz inspirow...

Proposal for a Method for Business Model Performance Assessment: Toward an Experimentation Tool for Business Model Innovation

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Antonio Batocchio

2017-04-01

Full Text Available The representation of business models has been recently widespread, especially in the pursuit of innovation. However, defining a company’s business model is sometimes limited to discussion and debates. This study observes the need for performance measurement so that business models can be data-driven. To meet this goal, the work proposed as a hypothesis the creation of a method that combines the practices of the Balanced Scorecard with a method of business models representation – the Business Model Canvas. Such a combination was based on study of conceptual adaptation, resulting in an application roadmap. A case study application was performed to check the functionality of the proposition, focusing on startup organizations. It was concluded that based on the performance assessment of the business model it is possible to propose the search for change through experimentation, a path that can lead to business model innovation.

'Leukodystrophy-like' phenotype in children with myelin oligodendrocyte glycoprotein antibody-associated disease.

Science.gov (United States)

Hacohen, Yael; Rossor, Thomas; Mankad, Kshitij; Chong, Wk 'Kling'; Lux, Andrew; Wassmer, Evangeline; Lim, Ming; Barkhof, Frederik; Ciccarelli, Olga; Hemingway, Cheryl

2018-04-01

To review the demographics and clinical and paraclinical parameters of children with myelin oligodendrocyte glycoprotein (MOG) antibody-associated relapsing disease. In this UK-based, multicentre study, 31 children with MOG antibody-associated relapsing disease were studied retrospectively. Of the 31 children studied, 14 presented with acute disseminated encephalomyelitis (ADEM); they were younger (mean 4.1y) than the remainder (mean 8.5y) who presented with optic neuritis and/or transverse myelitis (p<0.001). Similarly, children who had an abnormal brain magnetic resonance imaging (MRI) at onset (n=20) were younger than patients with normal MRI at onset (p=0.001) or at follow-up (p<0.001). 'Leukodystrophy-like' MRI patterns of confluent largely symmetrical lesions was seen during the course of the disease in 7 out of 14 children with a diagnosis of ADEM, and was only seen in children younger than 7 years of age. Their disability after a 3-year follow-up was mild to moderate, and most patients continued to relapse, despite disease-modifying treatments. MOG antibody should be tested in children presenting with relapsing neurological disorders associated with confluent, bilateral white matter changes, and distinct enhancement pattern. Children with MOG antibody-associated disease present with age-related differences in phenotypes, with a severe leukoencephalopathy phenotype in the very young and normal intracranial MRI in the older children. This finding suggests a susceptibility of the very young and myelinating brain to MOG antibody-mediated mechanisms of damage. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination manifest with an age-related phenotype. Children with MOG antibody and 'leukodystrophy-like' imaging patterns tend to have poor response to second-line immunotherapy. © 2017 Mac Keith Press.

Proposed higher order continuum-based models for an elastic ...

African Journals Online (AJOL)

Three new variants of continuum-based models for an elastic subgrade are proposed. The subgrade is idealized as a homogenous, isotropic elastic layer of thickness H overlying a firm stratum. All components of the stress tensor in the subgrade are taken into account. Reasonable assumptions are made regarding the ...

A proposal for operator team behavior model and operator's thinking mechanism

International Nuclear Information System (INIS)

Yoshimura, Seiichi; Takano, Kenichi; Sasou, Kunihide

1995-01-01

Operating environment in huge systems like nuclear power plants or airplanes is changing rapidly with the advance of computer technology. It is necessary to elucidate thinking process of operators and decision-making process of an operator team in abnormal situations, in order to prevent human errors under such environment. The Central Research Institute of Electric Power Industry is promoting a research project to establish human error prevention countermeasures by modeling and simulating the thinking process of operators and decision-making process of an operator team. In the previous paper, application of multilevel flow modeling was proposed to a mental model which conducts future prediction and cause identification, and the characteristics were verified by experienced plant operators. In this paper, an operator team behavior model and a fundamental operator's thinking mechanism especially 'situation understanding' are proposed, and the proposals are evaluated by experiments using a full-scale simulator. The results reveal that some assumptions such as 'communication is done between a leader and a follower' are almost appropriate and that the situation understanding can be represented by 'probable candidates for cause, determination of a parameter which changes when an event occurs, determination of parameters which are influenced by the change of the previous parameter, determination of a principal parameter and future prediction of the principal parameter'. (author)

Diagnostic algorithm for relapsing acquired demyelinating syndromes in children.

Science.gov (United States)

Hacohen, Yael; Mankad, Kshitij; Chong, W K; Barkhof, Frederik; Vincent, Angela; Lim, Ming; Wassmer, Evangeline; Ciccarelli, Olga; Hemingway, Cheryl

2017-07-18

To establish whether children with relapsing acquired demyelinating syndromes (RDS) and myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) show distinctive clinical and radiologic features and to generate a diagnostic algorithm for the main RDS for clinical use. A panel reviewed the clinical characteristics, MOG-Ab and aquaporin-4 (AQP4) Ab, intrathecal oligoclonal bands, and Epstein-Barr virus serology results of 110 children with RDS. A neuroradiologist blinded to the diagnosis scored the MRI scans. Clinical, radiologic, and serologic tests results were compared. The findings showed that 56.4% of children were diagnosed with multiple sclerosis (MS), 25.4% with neuromyelitis optica spectrum disorder (NMOSD), 12.7% with multiphasic disseminated encephalomyelitis (MDEM), and 5.5% with relapsing optic neuritis (RON). Blinded analysis defined baseline MRI as typical of MS in 93.5% of children with MS. Acute disseminated encephalomyelitis presentation was seen only in the non-MS group. Of NMOSD cases, 30.7% were AQP4-Ab positive. MOG-Ab were found in 83.3% of AQP4-Ab-negative NMOSD, 100% of MDEM, and 33.3% of RON. Children with MOG-Ab were younger, were less likely to present with area postrema syndrome, and had lower disability, longer time to relapse, and more cerebellar peduncle lesions than children with AQP4-Ab NMOSD. A diagnostic algorithm applicable to any episode of CNS demyelination leads to 4 main phenotypes: MS, AQP4-Ab NMOSD, MOG-Ab-associated disease, and antibody-negative RDS. Children with MS and AQP4-Ab NMOSD showed features typical of adult cases. Because MOG-Ab-positive children showed notable and distinctive clinical and MRI features, they were grouped into a unified phenotype (MOG-Ab-associated disease), included in a new diagnostic algorithm. © 2017 American Academy of Neurology.

Category-selective attention interacts with partial awareness processes in a continuous manner: An fMRI study

Directory of Open Access Journals (Sweden)

Shen Tu

2015-12-01

Full Text Available Recently, our team found that category-selective attention could modulate tool processing at the partial awareness level and unconscious face processing in the middle occipital gyrus (MOG. However, the modulation effects in MOG were in opposite directions across the masked tool and masked face conditions in that study: MOG activation decreased in the masked faces condition but increased in the masked tools condition under the consistent compared with the inconsistent cue-selective-attentional modulation. In the present study, in order to confirm that the opposite effects were due to the changed contours of the tools, using the same tool pictures and fMRI technique, we devised another two conditions: variant mirror tool picture condition and invariant tool picture condition. The results showed that, during the variant mirror tool picture condition, activation in the MOG decreased under tool-selective attention compared with face-selective attention. Interestingly, however, during the invariant tool picture condition, activation in the MOG revealed neither positive nor negative changes. Combined with the result of increased MOG activity in the changed different tool condition, the three different effects demonstrated not only that the unconscious component of partial awareness processing (no knowledge of the identity of the tool could be modulated by the category-selective attention in the earlier visual cortex but also that the modulation effect could further interact with the conscious component of partial awareness processing (consciousness of the changing contour of the tool in a continuous manner.

Multiple organ gigantism caused by mutation in VmPPD gene in blackgram (Vigna mungo).

Science.gov (United States)

Naito, Ken; Takahashi, Yu; Chaitieng, Bubpa; Hirano, Kumi; Kaga, Akito; Takagi, Kyoko; Ogiso-Tanaka, Eri; Thavarasook, Charaspon; Ishimoto, Masao; Tomooka, Norihiko

2017-03-01

Seed size is one of the most important traits in leguminous crops. We obtained a recessive mutant of blackgram that had greatly enlarged leaves, stems and seeds. The mutant produced 100% bigger leaves, 50% more biomass and 70% larger seeds though it produced 40% less number of seeds. We designated the mutant as multiple-organ-gigantism ( mog ) and found the mog phenotype was due to increase in cell numbers but not in cell size. We also found the mog mutant showed a rippled leaf ( rl ) phenotype, which was probably caused by a pleiotropic effect of the mutation. We performed a map-based cloning and successfully identified an 8 bp deletion in the coding sequence of VmPPD gene, an orthologue of Arabidopsis PEAPOD ( PPD ) that regulates arrest of cell divisions in meristematic cells . We found no other mutations in the neighboring genes between the mutant and the wild type. We also knocked down GmPPD genes and reproduced both the mog and rl phenotypes in soybean. Controlling PPD genes to produce the mog phenotype is highly valuable for breeding since larger seed size could directly increase the commercial values of grain legumes.

Bayesian inference of chemical kinetic models from proposed reactions

KAUST Repository

Galagali, Nikhil

2015-02-01

© 2014 Elsevier Ltd. Bayesian inference provides a natural framework for combining experimental data with prior knowledge to develop chemical kinetic models and quantify the associated uncertainties, not only in parameter values but also in model structure. Most existing applications of Bayesian model selection methods to chemical kinetics have been limited to comparisons among a small set of models, however. The significant computational cost of evaluating posterior model probabilities renders traditional Bayesian methods infeasible when the model space becomes large. We present a new framework for tractable Bayesian model inference and uncertainty quantification using a large number of systematically generated model hypotheses. The approach involves imposing point-mass mixture priors over rate constants and exploring the resulting posterior distribution using an adaptive Markov chain Monte Carlo method. The posterior samples are used to identify plausible models, to quantify rate constant uncertainties, and to extract key diagnostic information about model structure-such as the reactions and operating pathways most strongly supported by the data. We provide numerical demonstrations of the proposed framework by inferring kinetic models for catalytic steam and dry reforming of methane using available experimental data.

THE PROPOSED MODEL OF COLLABORATIVE VIRTUAL LEARNING ENVIRONMENT FOR INTRODUCTORY PROGRAMMING COURSE

Directory of Open Access Journals (Sweden)

Mahfudzah OTHMAN

2012-01-01

Full Text Available This paper discusses the proposed model of the collaborative virtual learning system for the introductory computer programming course which uses one of the collaborative learning techniques known as the “Think-Pair-Share”. The main objective of this study is to design a model for an online learning system that facilitates the collaborative learning activities in a virtual environment such as online communications and pair or small group discussions. In order to model the virtual learning environment, the RUP methodology has been used where it involves the data collection phase and the analysis and design phase. Fifty respondents have been randomly selected to participate in the data collection phase to investigate the students’ interest and learning styles as well as their learning preferences. The results have shown the needs for the development of online small group discussions that can be used as an alternative learning style for programming courses. The proposed design of the virtual learning system named as the Online Collaborative Learning System or OCLS is being depicted using the object-oriented models which are the use-case model and class diagram in order to show the concise processes of virtual “Think-Pair-Share” collaborative activities. The “Think-Pair-Share” collaborative learning technique that is being used in this model has been chosen because of its simplicity and relatively low-risk. This paper also presents the proposed model of the system’s architecture that will become the guidelines for the physical development of OCLS using the web-based applications.

The evaluation of doctoral thesis. A model proposal

Directory of Open Access Journals (Sweden)

de-Miguel, Mario

2010-04-01

Full Text Available The aim of this work is the development of a model that can be used as a framework for evaluators and PhD tribunal members, either during the previous administrative processing phase or at the actual exposition and viva on doctoral dissertations. To this end, once reviewed the existing literature and normative, a new proposal is laid out on the main aspects and criteria to be analysed and assessed from any given scientific work, thus introducing a tool that facilitates and specifies this work. Our model is intended to be an open proposal on which we would welcome any contribution and suggestion. El objetivo del presente trabajo es la elaboración de un modelo que pueda ser utilizado como marco de referencia por los evaluadores y miembros de tribunales de las tesis doctorales tanto en la fase previa a la tramitación administrativa como en el acto de exposición y defensa de la misma. Para ello, una vez revisada la literatura y la normativa vigente al respecto, efectuamos una propuesta sobre los principales aspectos y criterios que deben ser objeto de análisis y valoración en todo trabajo científico, y presentamos una herramienta que facilita y precisa esta tarea. Nuestro modelo constituye una propuesta abierta sobre la que esperamos aportaciones y sugerencias.

Media Accountability Systems: Models, proposals and outlooks

Directory of Open Access Journals (Sweden)

Luiz Martins da Silva

2007-06-01

Full Text Available This paper analyzes one of the basic actions of SOS-Imprensa, the mechanism to assure Media Accountability with the goal of proposing a synthesis of models for the Brazilian reality. The article aims to address the possibilities of creating and improving mechanisms to stimulate the democratic press process and to mark out and assure freedom of speech and personal rights with respect to the media. Based on the Press Social Responsibility Theory, the hypothesis is that the experiences analyzed (Communication Council, Press Council, Ombudsman and Readers Council are alternatives for accountability, mediation and arbitration, seeking visibility, trust and public support in favor of fairer media.

The Motivational Knowledge Management Model: proposal to apply it in the library sector

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Daniel López-Fernández

2016-12-01

Full Text Available In professional environments, attention paid to aspects such as supervisory styles, interpersonal relationships and workers eagerness can have a positive impact on employee motivation and, consequently, on their performance and well-being. To achieve this, knowledge management models such as those presented here can be applied. This model generates diagnoses of motivation and recommendations for improvement, both systematically and scientifically. Consequently, it is especially useful for managers and human resource departments. The proposed model can be adapted to different kinds of professional groups, including those in library and documentation services. The suitability, reliability and usefulness of the proposed model have been empirically checked through case studies with 92 students and 166 professionals. The positive results allow us to conclude that the model is effective and useful for assessing and improving motivation.

Patent portfolio management: literature review and a proposed model.

Science.gov (United States)

Conegundes De Jesus, Camila Kiyomi; Salerno, Mario Sergio

2018-05-09

Patents and patent portfolios are gaining attention in the last decades, from the called 'pro-patent era' to the recent billionaire transactions involving patent portfolios. The field is growing in importance, both theoretically and practically and despite having substantial literature on new product development portfolio management, we have not found an article relating this theory to patent portfolios. Areas covered: The paper develops a systematic literature review on patent portfolio management to organize the evolution and tendencies of patent portfolio management, highlighting distinctive features of patent portfolio management. Interview with IP manager of three life sciences companies, including a leading multinational group provided relevant information about patent portfolio management. Expert opinion: Based on the systematic literature review on portfolio management, more specifically, on new product development portfolio theory, and interview the paper proposes the paper proposes a reference model to manage patent portfolios. The model comprises four stages aligned with the three goals of the NPD portfolio management: 1 - Linking strategy of the Company's NPD Portfolio to Patent Portfolio; 2 - Balancing the portfolio in buckets; 3 - Patent Valuation (maximizing valuation); 4 - Regularly reviewing the patent portfolio.

Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice.

Directory of Open Access Journals (Sweden)

Rajwahrdhan Yadav

2010-08-01

Full Text Available Pertussis toxin (PTX, an exotoxin of Bordetella pertussis, enhances the development of experimental autoimmune diseases such as experimental autoimmune uveitis (EAU and experimental autoimmune encephalomyelitis (EAE in rodent models. The mechanisms of the promotion of experimental autoimmune diseases by PTX may be based upon PTX-induced disruption of the blood eye/brain barriers facilitating the infiltration of inflammatory cells, the modulation of inflammatory cell migration and the enhancement of the activation of inflammatory cells. We hypothesized that the facilitation of experimental autoimmunity by PTX suggests that its influence on the in vivo immune response to auto-antigen may differ from its influence on non-self antigens.We have evaluated the effect of PTX on the simultaneous generation of delayed type hypersensitivity (DTH responses and autoimmune responses to uveitogenic interphotoreceptor retinoid binding protein peptide (IRBP161-180, encephalitogenic myelin oligodendrocyte glycoprotein peptide (MOG35-55 or ovalbumin (OVA. PTX injection of mice immunized to IRBP peptide161-180 led to (i the development of EAU as shown by histopathology of the retina, (ii pro-inflammatory cytokine production by splenocytes in response to IRBP peptide161-180, and (iii symptomatic EAE in mice immunized with encephalitogenic MOG peptide35-55. However, mice that received PTX had a reduced DTH response to IRBP161-180 peptide or MOG peptide35-55 when challenged distal to the site affected by autoreactive T cells. Moreover, footpad challenge with MOG35-55 peptide reduced EAE in mice immunized with MOG peptide. In contrast, the use of PTX when immunizing with OVA protein or an OVA immunogenic peptide did not affect the DTH response to OVA.The results suggest that that the reduced DTH response in mice receiving PTX may be specific for autoantigens and autoantigen-reactive T cells are diverted away from ectopic sites that received the autoantigen and towards

Proposal of a theoretical model for the practical nurse

Directory of Open Access Journals (Sweden)

Dolores Abril Sabater

2010-01-01

Full Text Available AIM: To determine which model of nursing is proposed by care professionals and the reason for their choice. METHOD: cross-sectional, descriptive study design. The main variable: Nursing Models and Theories. As secondary variables were collected: age, gender, years of work experience, nursing model of basic training, and course/s related. We used a self-elaborated, anonymous questionnaire, passed between April - May, 2006. Not random sample.RESULTS: 546 nurses were invited, answered 205. 38 % response rate. Virginia Henderson was the more selected model (33%, however, 42% left the question blank, 12% indicated that they wanted to work under the guidance of a model. They selected a specifically model: Knowledge of the model to their training, standardization in other centers, the characteristics of the model itself and identification with its philosophy. They are not decided by a model by ignorance, lack of time and usefulness. CONCLUSIONS: The model chosen mostly for their daily work was Virginia Henderson model, so that knowledge of a model is the main reason for their election. Professionals who choose not to use the model in their practice realize offers and calling for resources, besides to explain the lack of knowledge on this topic. To advance the nursing profession is necessary that nurse is thought over widely on the abstract concepts of the theory in our context.

Proposal of a Model for effective Management and Development of virtual Teams

Directory of Open Access Journals (Sweden)

Petr Skyrik

2010-10-01

Full Text Available The main aim of this paper is to present a pilot proposal of a model of “Virtual Development Management System” (ViDeMaS which will facilitate more effective management and development of virtual teams. Management and development of virtual teams is not a simple concept. It comprises a body of knowledge from a number of fields and scientific disciplines. The complexity of the concept may not be simplified as it is absolutely essential for full understanding of its nature. In order to gain better orientation in the concept, different perspectives will be used in the description of the model, which will enable us to achieve the goal of the work and to present the main results of the work (creation of a model for Virtual Development Management System. The present paper thus describes from different perspectives the proposal of a sufficiently detailed and complex model that may be utilized both on theoretical and application level.

Od przekonywania do współdecydowania : zarządzanie konfliktami wokół ryzyka i technologii

OpenAIRE

Stankiewicz, Piotr

2011-01-01

Nowe technologie mogą wywoływać kontrowersje społeczne: po pierwsze, ich rozwój i stosowanie mogą bezpośrednio skutkować oporem społecznym i konfliktami, jak dzieje się na przykład w przypadku biotechnologii, energii atomowej, technologii in vitro, nanotechnologii; po drugie, mogą one wywoływać niepożądane skutki, takie jak zanieczyszczenie środowiska, globalne ocieplenie klimatu, rozpowszechnienie się nowych epidemii (BSE, świńska i ptasia grypa). U źródeł konfliktów społecznych powstając...

Evaluation of a proposed optimization method for discrete-event simulation models

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Alexandre Ferreira de Pinho

2012-12-01

Full Text Available Optimization methods combined with computer-based simulation have been utilized in a wide range of manufacturing applications. However, in terms of current technology, these methods exhibit low performance levels which are only able to manipulate a single decision variable at a time. Thus, the objective of this article is to evaluate a proposed optimization method for discrete-event simulation models based on genetic algorithms which exhibits more efficiency in relation to computational time when compared to software packages on the market. It should be emphasized that the variable's response quality will not be altered; that is, the proposed method will maintain the solutions' effectiveness. Thus, the study draws a comparison between the proposed method and that of a simulation instrument already available on the market and has been examined in academic literature. Conclusions are presented, confirming the proposed optimization method's efficiency.

Evaluation of six NEHRP B/C crustal amplification models proposed for use in western North America

Science.gov (United States)

Boore, David; Campbell, Kenneth W.

2016-01-01

We evaluate six crustal amplification models based on National Earthquake Hazards Reduction Program (NEHRP) B/C crustal profiles proposed for use in western North America (WNA) and often used in other active crustal regions where crustal properties are unknown. One of the models is based on an interpolation of generic rock velocity profiles previously proposed for WNA and central and eastern North America (CENA), in conjunction with material densities based on an updated velocity–density relationship. A second model is based on the velocity profile used to develop amplification factors for the Next Generation Attenuation (NGA)‐West2 project. A third model is based on a near‐surface velocity profile developed from the NGA‐West2 site database. A fourth model is based on velocity and density profiles originally proposed for use in CENA but recently used to represent crustal properties in California. We propose two alternatives to this latter model that more closely represent WNA crustal properties. We adopt a value of site attenuation (κ0) for each model that is either recommended by the author of the model or proposed by us. Stochastic simulation is used to evaluate the Fourier amplification factors and their impact on response spectra associated with each model. Based on this evaluation, we conclude that among the available models evaluated in this study the NEHRP B/C amplification model of Boore (2016) best represents median crustal amplification in WNA, although the amplification models based on the crustal profiles of Kamai et al. (2013, 2016, unpublished manuscript, see Data and Resources) and Yenier and Atkinson (2015), the latter adjusted to WNA crustal properties, can be used to represent epistemic uncertainty.

Proposed Model of Information Behaviour in Crisis: The Case of Hurricane Sandy

Science.gov (United States)

Lopatovska, Irene; Smiley, Bobby

2013-01-01

Introduction: The paper proposes a model of information behaviour in crisis. No previous model has attempted to integrate information resources, information behaviour and needs of the storm-affected communities within the temporal stages of a natural disaster. Method: The study was designed as autoethnography. The data were collected through a…

The Proposed Model of Collaborative Virtual Learning Environment for Introductory Programming Course

Science.gov (United States)

Othman, Mahfudzah; Othman, Muhaini

2012-01-01

This paper discusses the proposed model of the collaborative virtual learning system for the introductory computer programming course which uses one of the collaborative learning techniques known as the "Think-Pair-Share". The main objective of this study is to design a model for an online learning system that facilitates the…

Socializing by Gaming : Revealing Social Relationships in Multiplayer Online Games

NARCIS (Netherlands)

Jia, L.; Shen, S.; van de Bovenkamp, R.; Iosup, A.; Kuipers, F.A.; Epema, D.H.J.

2015-01-01

Multiplayer Online Games (MOGs) like Defense of the Ancients and StarCraft II have attracted hundreds of millions of users who communicate, interact, and socialize with each other through gaming. In MOGs, rich social relationships emerge and can be used to improve gaming services such as match

Development-based Trust: Proposing and Validating a New Trust Measurement Model for Buyer-Seller Relationships

Directory of Open Access Journals (Sweden)

José Mauro da Costa Hernandez

2010-04-01

Full Text Available This study proposes and validates a trust measurement model for buyer-seller relationships. Baptized as development-based trust, the model encompasses three dimensions of trust: calculus-based, knowledge-based and identification-based. In addition to recognizing that trust is a multidimensional construct, the model also assumes that trust can evolve to take on a different character depending on the stage of the relationship. In order to test the proposed model and compare it to the characteristic-based trust measurement model, the measure most frequently used in the buyer-seller relationship literature, data were collected from 238 clients of an IT product wholesaler. The results show that the scales are valid and reliable and the proposed development-based trust measurement model is superior to the characteristic-based trust measurement model in terms of its ability to explain certain variables of interest in buyer-seller relationships (long-term relationship orientation, information sharing, behavioral loyalty and future intentions. Implications for practice, limitations and suggestions for future studies are discussed.

Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor

DEFF Research Database (Denmark)

Tran, E H; Kuziel, W A; Owens, T

2000-01-01

-type mice in Th1 cytokine gene expression, the kinetics and severity of disease, and infiltration of the central nervous system by lymphocytes, macrophages and granulocytes. RNase protection assays showed comparable accumulation of mRNA for the chemokines interferon-inducible protein-10, RANTES, macrophage...... and its CCR5 receptor in the induction of EAE by immunizing C57BL / 6 mice deficient in either MIP-1alpha or CCR5 with myelin oligodendrocyte glycoprotein (MOG). We found that MIP-1alpha-deficient mice were fully susceptible to MOG-induced EAE. These knockout animals were indistinguishable from wild...... chemoattractant protein-1, MIP-1beta, MIP-2, lymphotactin and T cell activation gene-3 during the course of the disease. CCR5-deficient mice were also susceptible to disease induction by MOG. The dispensability of MIP-1alpha and CCR5 for MOG-induced EAE in C57BL / 6 mice supports the idea that differential...

Gray Matter Hypoxia in the Brain of the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Science.gov (United States)

Johnson, Thomas W.; Wu, Ying; Nathoo, Nabeela; Rogers, James A.; Wee Yong, V.; Dunn, Jeff F.

2016-01-01

Background Multiple sclerosis (MS) has a significant inflammatory component and may have significant gray matter (GM) pathophysiology. Brain oxygenation is a sensitive measurement of the balance between metabolic need and oxygen delivery. There is evidence that inflammation and hypoxia are interdependent. In this paper, we applied novel, implanted PO2 sensors to measure hypoxia in cortical and cerebellar GM, in an inflammation-induced mouse model of MS. Objective Quantify oxygenation in cortical and cerebellar GM in the awake, unrestrained experimental autoimmune encephalomyelitis (EAE) mouse model and to relate the results to symptom level and disease time-course. Methods C57BL/6 mice were implanted with a fiber-optic sensor in the cerebellum (n = 13) and cortex (n = 24). Animals were induced with stimulation of the immune response and sensitization to myelin oligodendrocyte glycoprotein (MOG). Controls did not have MOG. We measured PO2 in awake, unrestrained animals from pre-induction (baseline) up to 36 days post-induction for EAE and controls. Results There were more days with hypoxia than hyperoxia (cerebellum: 34/67 vs. 18/67 days; cortex: 85/112 vs. 22/112) compared to time-matched controls. The average decline in PO2 on days that were significantly lower than time-matched controls was -8.8±6.0 mmHg (mean ± SD) for the cerebellum and -8.0±4.6 for the cortex. Conversely, the average increase in PO2 on days that were significantly hyperoxic was +3.2±2.8 mmHg (mean ± SD) for the cerebellum and +0.8±2.1 for the cortex. Cortical hypoxia related to increased behavioral deficits. Evidence for hypoxia occurred before measurable behavioral deficits. Conclusions A highly inflammatory condition primed to a white matter (WM) autoimmune response correlates with significant hypoxia and increased variation in oxygenation in GM of both cerebellum and cortex in the mouse EAE model of MS. PMID:27907119

DEVELOPING AND PROPOSING A CONCEPTUAL MODEL OF THE FLOW EXPERIENCE DURING ONLINE INFORMATION SEARCH

Directory of Open Access Journals (Sweden)

Lazoc Alina

2012-07-01

Full Text Available Information search is an essential part of the consumer`s decision making process. The online medium offers new opportunities and challenges for information search activities (in and outside the marketing context. We are interested in the way human information experiences and behaviors are affected by this. Very often online games and social web activities are perceived as challenging, engaging and enjoyable, while online information search is far below this evaluation. Our research proposal implies that using the online medium for information search may provoke enjoyable experiences through the flow state, which may in turn positively influence an individual`s exploratory information behavior and encourage his/her pro-active market behavior. The present study sets out to improve the understanding of the online medium`s impact on human`s exploratory behavior. We hypothesize that the inclusion of the online flow experience in our research model will better explain exploratory information search behaviors. A 11-component conceptual framework is proposed to explain the manifestations of flow, its personal and technological determinants and its behavioral consequence in the context of online information search. Our research has the primary purpose to present an integrated online flow model. Its secondary objective is to stimulate extended research in the area of informational behaviors in the digital age. The paper is organized in three sections. In the first section we briefly report the analysis results of the most relevant online flow theory literature and, drawing on it, we are trying to identify variables and relationships among these. In the second part we propose a research model and use prior flow models to specify a range of testable hypothesis. Drawing on the conceptual model developed, the last section of our study presents the final conclusions and proposes further steps in evaluating the model`s validity. Future research directions

Association between abnormal serum myelin-specific protein levels and white matter integrity in first-episode and drug-naïve patients with major depressive disorder.

Science.gov (United States)

Jiang, Linling; Cheng, Yuqi; Jiang, Hongyan; Xu, Jian; Lu, Jin; Shen, Zonglin; Lu, Yi; Liu, Fang; Li, Luqiong; Xu, Xiufeng

2018-05-01

Although the structural abnormalities of white matter (WM) have been described in patients with major depressive disorder (MDD), the neuropathological changes remain unclear. The current study aimed to investigate the myelin oligodendrocyte glycoprotein (MOG) and myelin-associated glycoprotein (MAG) levels and their correlations with WM integrity in first-episode, drug-naïve MDD patients. We obtained diffusion tensor images of 102 first-episode, drug-naïve MDD patients and 81 age- and sex-matched controls. Serum MOG and MAG levels of all participants were measured and compared between the two groups. The correlations between WM integrity and MOG and MAG levels were examined. MOG and MAG serum levels were significantly higher in MDD patients than in controls. Patients with MDD also showed decreased fractional anisotropy (FA) and axial diffusivity in the WM of the bilateral thalamus, right hippocampus, right temporal lobe, and left pulvinar. At the whole-brain level, no regions showed any correlations of diffusivity parameters with MOG or MAG levels in healthy subjects. However, we observed two-way correlations between the MOG and MAG levels and the FA and mean diffusivity values in the WM of the left middle frontal lobe, right inferior parietal lobe, and right supplementary motor area in MDD patients. Further investigation with a larger sample size and longitudinal studies are required to better understand the neuropathology of WM integrity in MDD. Our findings represent the first evidence of a relationship between abnormal serum myelin-specific protein levels and impaired WM integrity, which may help to better understand the neurobiological mechanisms of MDD. Copyright © 2018 Elsevier B.V. All rights reserved.

The Associative Basis of Scientific Creativity: A Model Proposal

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Esra Kanli

2014-06-01

Full Text Available Creativity is accepted as an important part of scientific skills. Scientific creativity proceeds from a need or urge to solve a problem, and in-volves the production of original and useful ideas or products. Existing scientific creativity theories and tests do not feature the very im-portant thinking processes, such as analogical and associative thinking, which can be consid-ered crucial in creative scientific problem solv-ing. Current study’s aim is to provide an alter-native model and explicate the associative basis of scientific creativity. Emerging from the re-viewed theoretical framework, Scientific Asso-ciations Model is proposed. This model claims that, similarity and mediation constitutes the basis of creativity and focuses on three compo-nents namely; associative thinking, analogical thinking (analogical reasoning & analogical problem solving and insight which are consid-ered to be main elements of scientific associa-tive thinking.

A Framework Proposal For Choosing A New Business Implementation Model In Henkel

OpenAIRE

Li, Tsz Wan

2015-01-01

Henkel's New Business team is a corporate venturing unit that explores corporate entrepreneurial activities on behalf of Henkel Adhesives Technologies. The new business ideas are implemented through one of these models: incubator, venturing or innovation ecosystem. In current practice, there is no systematic framework in place to choose the implementation model. The goal of the thesis is to propose a framework for choosing the most appropriate model for implementation of a new business idea i...

Proposal for operator's mental model using the concept of multilevel flow modeling

International Nuclear Information System (INIS)

Yoshimura, Seiichi; Takano, Kenichi; Sasou, Kunihide

1995-01-01

It is necessary to analyze an operator's thinking process and a operator team's intension forming process for preventing human errors in a highly advanced huge system like a nuclear power plant. Central Research Institute of Electric Power Industry is promoting a research project to establish human error prevention countermeasures by modeling the thinking and intension forming process. The important is the future prediction and the cause identification when abnormal situations occur in a nuclear power plant. The concept of Multilevel Flow Modeling (MFM) seems to be effective as an operator's mental model which performs the future prediction and the cause identification. MFM is a concept which qualitatively describes the plant functions by energy and mass flows and also describes the plant status by breaking down the targets in a hierarchical manner which a plant should achieve. In this paper, an operator's mental model using the concept of MFM was proposed and a nuclear power plant diagnosis support system using MFM was developed. The system evaluation test by personnel who have operational experience in nuclear power plants revealed that MFM was superior in the future prediction and the cause identification to a traditional nuclear power plant status display system which used mimics and trends. MFM proved to be useful as an operator's mental model by the test. (author)

Proposal of a pedagogical model for mathematics teacher education

Directory of Open Access Journals (Sweden)

Alfonso Jiménez Espinosa

2011-01-01

Full Text Available This research-based article reflects on mathematics teacher education, and proposes a pedagogical model for this purpose, called Gradual Research Pedagogical Model (MPGI. This model considers the central curricular elements of any academic education process: student, teacher and contents, with evaluation as transversal element for analysis and feedback. The training of future teachers is constituted by three moments, each with its specific emphasis: the first is “contextualization”, which aims at having the student understand his or her new academic role, and identify and overcome his or her academic weak points, the second is “knowledge foundation”, which offers basic education in the fields of mathematics and pedagogy, as well as sensibilization towards social issues, opening up the student’s possibilities as leader and agent of change, and lastly, “knowledge immersion”, which is centered on research and the identification and study of topics and problems of the mathematical discipline as well as the pedagogical field.

Assessment of nutritional status in the elderly: a proposed function-driven model.

Science.gov (United States)

Engelheart, Stina; Brummer, Robert

2018-01-01

There is no accepted or standardized definition of 'malnutrition'. Hence, there is also no definition of what constitutes an adequate nutritional status. In elderly people, assessment of nutritional status is complex and is complicated by multi-morbidity and disabilities combined with nutrition-related problems, such as dysphagia, decreased appetite, fatigue, and muscle weakness. We propose a nutritional status model that presents nutritional status from a comprehensive functional perspective. This model visualizes the complexity of the nutritional status in elderly people. The presented model could be interpreted as the nutritional status is conditional to a person's optimal function or situation. Another way of looking at it might be that a person's nutritional status affects his or her optimal situation. The proposed model includes four domains: (1) physical function and capacity; (2) health and somatic disorders; (3) food and nutrition; and (4) cognitive, affective, and sensory function. Each domain has a major impact on nutritional status, which in turn has a major impact on the outcome of each domain. Nutritional status is a multifaceted concept and there exist several knowledge gaps in the diagnosis, prevention, and optimization of treatment of inadequate nutritional status in elderly people. The nutritional status model may be useful in nutritional assessment research, as well as in the clinical setting.

A proposal on alternative sampling-based modeling method of spherical particles in stochastic media for Monte Carlo simulation

Energy Technology Data Exchange (ETDEWEB)

Kim, Song Hyun; Lee, Jae Yong; KIm, Do Hyun; Kim, Jong Kyung [Dept. of Nuclear Engineering, Hanyang University, Seoul (Korea, Republic of); Noh, Jae Man [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-08-15

Chord length sampling method in Monte Carlo simulations is a method used to model spherical particles with random sampling technique in a stochastic media. It has received attention due to the high calculation efficiency as well as user convenience; however, a technical issue regarding boundary effect has been noted. In this study, after analyzing the distribution characteristics of spherical particles using an explicit method, an alternative chord length sampling method is proposed. In addition, for modeling in finite media, a correction method of the boundary effect is proposed. Using the proposed method, sample probability distributions and relative errors were estimated and compared with those calculated by the explicit method. The results show that the reconstruction ability and modeling accuracy of the particle probability distribution with the proposed method were considerably high. Also, from the local packing fraction results, the proposed method can successfully solve the boundary effect problem. It is expected that the proposed method can contribute to the increasing of the modeling accuracy in stochastic media.

A proposal on alternative sampling-based modeling method of spherical particles in stochastic media for Monte Carlo simulation

International Nuclear Information System (INIS)

Kim, Song Hyun; Lee, Jae Yong; KIm, Do Hyun; Kim, Jong Kyung; Noh, Jae Man

2015-01-01

Chord length sampling method in Monte Carlo simulations is a method used to model spherical particles with random sampling technique in a stochastic media. It has received attention due to the high calculation efficiency as well as user convenience; however, a technical issue regarding boundary effect has been noted. In this study, after analyzing the distribution characteristics of spherical particles using an explicit method, an alternative chord length sampling method is proposed. In addition, for modeling in finite media, a correction method of the boundary effect is proposed. Using the proposed method, sample probability distributions and relative errors were estimated and compared with those calculated by the explicit method. The results show that the reconstruction ability and modeling accuracy of the particle probability distribution with the proposed method were considerably high. Also, from the local packing fraction results, the proposed method can successfully solve the boundary effect problem. It is expected that the proposed method can contribute to the increasing of the modeling accuracy in stochastic media

PROPOSAL OF A MODEL MANAGEMENT TO SMALL DESIGN COMPANIES

Directory of Open Access Journals (Sweden)

Otávio José de OLIVEIRA

2008-11-01

Full Text Available The main purpose of this paper is the proposition of a management model specifically developed for small building design firms, aligned with their needs and particularities. The field research was conducted with a qualitative approach through the analysis of four case studies in small building design firms acting mainly in São Paulo City. The data collection was accomplished through semi-structured interviews, direct observation and analysis of documents. The proposed model includes guidance to the management of the core processes and activities of small building design firms, such as: organizational structure; strategic planning; planning and control of design process; costs management; sales management; information systems; human resources management; services added to the design; and performance evaluation. Key-words: design firms; design process; building construction.

Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study.

Science.gov (United States)

Seed, Mike; van Amerom, Joshua F P; Yoo, Shi-Joon; Al Nafisi, Bahiyah; Grosse-Wortmann, Lars; Jaeggi, Edgar; Jansz, Michael S; Macgowan, Christopher K

2012-11-26

We present the first phase contrast (PC) cardiovascular magnetic resonance (CMR) measurements of the distribution of blood flow in twelve late gestation human fetuses. These were obtained using a retrospective gating technique known as metric optimised gating (MOG). A validation experiment was performed in five adult volunteers where conventional cardiac gating was compared with MOG. Linear regression and Bland Altman plots were used to compare MOG with the gold standard of conventional gating. Measurements using MOG were then made in twelve normal fetuses at a median gestational age of 37 weeks (range 30-39 weeks). Flow was measured in the major fetal vessels and indexed to the fetal weight. There was good correlation between the conventional gated and MOG measurements in the adult validation experiment (R=0.96). Mean flows in ml/min/kg with standard deviations in the major fetal vessels were as follows: combined ventricular output (CVO) 540 ± 101, main pulmonary artery (MPA) 327 ± 68, ascending aorta (AAo) 198 ± 38, superior vena cava (SVC) 147 ± 46, ductus arteriosus (DA) 220 ± 39,pulmonary blood flow (PBF) 106 ± 59,descending aorta (DAo) 273 ± 85, umbilical vein (UV) 160 ± 62, foramen ovale (FO)107 ± 54. Results expressed as mean percentages of the CVO with standard deviations were as follows: MPA 60 ± 4, AAo37 ± 4, SVC 28 ± 7, DA 41 ± 8, PBF 19 ± 10, DAo50 ± 12, UV 30 ± 9, FO 21 ± 12. This study demonstrates how PC CMR with MOG is a feasible technique for measuring the distribution of the normal human fetal circulation in late pregnancy. Our preliminary results are in keeping with findings from previous experimental work in fetal lambs.

Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study

Directory of Open Access Journals (Sweden)

Seed Mike

2012-11-01

Full Text Available Abstract Background We present the first phase contrast (PC cardiovascular magnetic resonance (CMR measurements of the distribution of blood flow in twelve late gestation human fetuses. These were obtained using a retrospective gating technique known as metric optimised gating (MOG. Methods A validation experiment was performed in five adult volunteers where conventional cardiac gating was compared with MOG. Linear regression and Bland Altman plots were used to compare MOG with the gold standard of conventional gating. Measurements using MOG were then made in twelve normal fetuses at a median gestational age of 37 weeks (range 30–39 weeks. Flow was measured in the major fetal vessels and indexed to the fetal weight. Results There was good correlation between the conventional gated and MOG measurements in the adult validation experiment (R=0.96. Mean flows in ml/min/kg with standard deviations in the major fetal vessels were as follows: combined ventricular output (CVO 540±101, main pulmonary artery (MPA 327±68, ascending aorta (AAo 198±38, superior vena cava (SVC 147±46, ductus arteriosus (DA 220±39,pulmonary blood flow (PBF 106±59,descending aorta (DAo 273±85, umbilical vein (UV 160±62, foramen ovale (FO107±54. Results expressed as mean percentages of the CVO with standard deviations were as follows: MPA 60±4, AAo37±4, SVC 28±7, DA 41±8, PBF 19±10, DAo50±12, UV 30±9, FO 21±12. Conclusion This study demonstrates how PC CMR with MOG is a feasible technique for measuring the distribution of the normal human fetal circulation in late pregnancy. Our preliminary results are in keeping with findings from previous experimental work in fetal lambs.

A Proposed Analytical Model for Integrated Pick-and-Sort Systems

Directory of Open Access Journals (Sweden)

Recep KIZILASLAN

2013-11-01

Full Text Available In this study we present an analytical approach for integration of order picking and sortation operations which are the most important, labour intensive and costly activity for warehouses. Main aim is to investigate order picking and sorting efficiencies under different design issues as a function of order wave size. Integrated analytical model is proposed to estimate the optimum order picking and order sortation efficiency. The model, which has been tested by simulations with different illustrative examples, calculates the optimum wave size that solves the trade-off between picking and sorting operations and makes the order picking and sortations efficiency maximum. Our model also allow system designer to predict the order picking and sorting capacity for different system configurations. This study presents an innovative approach for integrated warehouse operations.

A proposed model for the transfer of environmental tritium to man and tritium metabolism in model animals

International Nuclear Information System (INIS)

Saito, Masahiro; Ishida, M.R.

1987-01-01

To evaluate the accumulated dose in human bodies due to the environmental tritium, it is of required to establish an adequate model for the tritium transfer from the environment to man and to obtain enough information on the metabolic behaviour of tritium in animal bodies using model animal system. In this report, first we describe about a proposed model for the transfer of environmental tritium to man and secondly mention briefly about the recent works on the tritium metabolism in newborn animals which have been treated as a model system of tritium intake through food chain. (author)

Databases for highway inventories. Proposal for a new model

Energy Technology Data Exchange (ETDEWEB)

Perez Casan, J.A.

2016-07-01

Database models for highway inventories are based on classical schemes for relational databases: many related tables, in which the database designer establishes, a priori, every detail that they consider relevant for inventory management. This kind of database presents several problems. First, adapting the model and its applications when new database features appear is difficult. In addition, the different needs of different sets of road inventory users are difficult to fulfil with these schemes. For example, maintenance management services, road authorities and emergency services have different needs. In addition, this kind of database cannot be adapted to new scenarios, such as other countries and regions (that may classify roads or name certain elements differently). The problem is more complex if the language used in these scenarios is not the same as that used in the database design. In addition, technicians need a long time to learn to use the database efficiently. This paper proposes a flexible, multilanguage and multipurpose database model, which gives an effective and simple solution to the aforementioned problems. (Author)

Proposed model for fuel-coolant mixing during a core-melt accident

International Nuclear Information System (INIS)

Corradini, M.L.

1983-01-01

If complete failure of normal and emergency coolant flow occurs in a light water reactor, fission product decay heat would eventually cause melting of the reactor fuel and cladding. The core melt may then slump into the lower plenum and later into the reactor cavity and contact residual liquid water. A model is proposed to describe the fuel-coolant mixing process upon contact. The model is compared to intermediate scale experiments being conducted at Sandia. The modelling of this mixing process will aid in understanding three important processes: (1) fuel debris sizes upon quenching in water, (2) the hydrogen source term during fuel quench, and (3) the rate of steam production. Additional observations of Sandia data indicate that the steam explosion is affected by this mixing process

78 FR 38091 - Airworthiness Criteria: Proposed Airship Design Criteria for Lockheed Martin Aeronautics Model...

Science.gov (United States)

2013-06-25

..., 2012 Lockheed Martin Aeronautics submitted an application for type certification for the model LMZ1M..., views, or arguments as they may desire. Commenters should identify the proposed design criteria on the... Lockheed Martin Aeronautics submitted an application for type certification for the model LMZ1M airship...

[Social determinants of odontalgia in epidemiological studies: theoretical review and proposed conceptual model].

Science.gov (United States)

Bastos, João Luiz Dornelles; Gigante, Denise Petrucci; Peres, Karen Glazer; Nedel, Fúlvio Borges

2007-01-01

The epidemiological literature has been limited by the absence of a theoretical framework reflecting the complexity of causal mechanisms for the occurrence of health phenomena / disease conditions. In the field of oral epidemiology, such lack of theory also prevails, since dental caries the leading topic in oral research has been often studied through a biological and reductionist viewpoint. One of the most important consequences of dental caries is dental pain (odontalgia), which has received little attention in studies with sophisticated theoretical models and powerful designs to establish causal relationships. The purpose of this study is to review the scientific literature on the determinants of odontalgia and to discuss theories proposed for the explanation of the phenomenon. Conceptual models and emerging theories on the social determinants of oral health are revised, in an attempt to build up links with the bio-psychosocial pain model, proposing a more elaborate causal model for odontalgia. The framework suggests causal pathways between social structure and oral health through material, psychosocial and behavioral pathways. Aspects of the social structure are highlighted in order to relate them to odontalgia, stressing their importance in discussions of causal relationships in oral health research.

AN EFFECTIVE RISK-PREVENTIVE MODEL PROPOSAL FOR OCCUPATIONAL ACCIDENTS AT SHIPYARDS

Directory of Open Access Journals (Sweden)

Ozge Acuner

2016-03-01

Full Text Available According to the statistics of occupational accidents, it is observed that the number of accidents occurred in shipbuilding industry is high and the rate of deaths and serious injuries among these accidents is higher than in other industries. However, the number of the studies to prevent these accidents in both industrial and scientific practices is considerably low. Therefore, the objective of this study is to develop an efficient risk preventive model in accordance with occupational health and safety regulations for industrial organizations. The approach proposed in this study differs from those described in the literature, because it is based on fuzzy set theory in order to cope with uncertainties on probability and severity definitions in terms of occupational health and safety. Furthermore, in this paper, risk severity is considered in terms of harm to worker, harm to environment, and harm to hardware, whereas in the literature, risk severity is generally considered solely in terms of only harm to worker. Then, risk magnitude is obtained by utilizing fuzzy inference system. The proposed approach is applied to a shipyard located in the Marmara Region in order to illustrate the applicability of the model.

MO-G-304-01: FEATURED PRESENTATION: Expanding the Knowledge Base for Data-Driven Treatment Planning: Incorporating Patient Outcome Models

International Nuclear Information System (INIS)

Robertson, SP; Quon, H; Cheng, Z; Moore, JA; Bowers, M; McNutt, TR

2015-01-01

Purpose: To extend the capabilities of knowledge-based treatment planning beyond simple dose queries by incorporating validated patient outcome models. Methods: From an analytic, relational database of 684 head and neck cancer patients, 372 patients were identified having dose data for both left and right parotid glands as well as baseline and follow-up xerostomia assessments. For each existing patient, knowledge-based treatment planning was simulated for by querying the dose-volume histograms and geometric shape relationships (overlap volume histograms) for all other patients. Dose predictions were captured at normalized volume thresholds (NVT) of 0%, 10%, 20, 30%, 40%, 50%, and 85% and were compared with the actual achieved doses using the Wilcoxon signed-rank test. Next, a logistic regression model was used to predict the maximum severity of xerostomia up to three months following radiotherapy. Baseline xerostomia scores were subtracted from follow-up assessments and were also included in the model. The relative risks from predicted doses and actual doses were computed and compared. Results: The predicted doses for both parotid glands were significantly less than the achieved doses (p < 0.0001), with differences ranging from 830 cGy ± 1270 cGy (0% NVT) to 1673 cGy ± 1197 cGy (30% NVT). The modelled risk of xerostomia ranged from 54% to 64% for achieved doses and from 33% to 51% for the dose predictions. Relative risks varied from 1.24 to 1.87, with maximum relative risk occurring at 85% NVT. Conclusions: Data-driven generation of treatment planning objectives without consideration of the underlying normal tissue complication probability may Result in inferior plans, even if quality metrics indicate otherwise. Inclusion of complication models in knowledge-based treatment planning is necessary in order to close the feedback loop between radiotherapy treatments and patient outcomes. Future work includes advancing and validating complication models in the context

MO-G-304-01: FEATURED PRESENTATION: Expanding the Knowledge Base for Data-Driven Treatment Planning: Incorporating Patient Outcome Models

Energy Technology Data Exchange (ETDEWEB)

Robertson, SP; Quon, H; Cheng, Z; Moore, JA; Bowers, M; McNutt, TR [Johns Hopkins University, Baltimore, MD (United States)

2015-06-15

Purpose: To extend the capabilities of knowledge-based treatment planning beyond simple dose queries by incorporating validated patient outcome models. Methods: From an analytic, relational database of 684 head and neck cancer patients, 372 patients were identified having dose data for both left and right parotid glands as well as baseline and follow-up xerostomia assessments. For each existing patient, knowledge-based treatment planning was simulated for by querying the dose-volume histograms and geometric shape relationships (overlap volume histograms) for all other patients. Dose predictions were captured at normalized volume thresholds (NVT) of 0%, 10%, 20, 30%, 40%, 50%, and 85% and were compared with the actual achieved doses using the Wilcoxon signed-rank test. Next, a logistic regression model was used to predict the maximum severity of xerostomia up to three months following radiotherapy. Baseline xerostomia scores were subtracted from follow-up assessments and were also included in the model. The relative risks from predicted doses and actual doses were computed and compared. Results: The predicted doses for both parotid glands were significantly less than the achieved doses (p < 0.0001), with differences ranging from 830 cGy ± 1270 cGy (0% NVT) to 1673 cGy ± 1197 cGy (30% NVT). The modelled risk of xerostomia ranged from 54% to 64% for achieved doses and from 33% to 51% for the dose predictions. Relative risks varied from 1.24 to 1.87, with maximum relative risk occurring at 85% NVT. Conclusions: Data-driven generation of treatment planning objectives without consideration of the underlying normal tissue complication probability may Result in inferior plans, even if quality metrics indicate otherwise. Inclusion of complication models in knowledge-based treatment planning is necessary in order to close the feedback loop between radiotherapy treatments and patient outcomes. Future work includes advancing and validating complication models in the context

Identification of gene expression patterns crucially involved in experimental autoimmune encephalomyelitis and multiple sclerosis

Directory of Open Access Journals (Sweden)

Martin M. Herrmann

2016-10-01

Full Text Available After encounter with a central nervous system (CNS-derived autoantigen, lymphocytes leave the lymph nodes and enter the CNS. This event leads only rarely to subsequent tissue damage. Genes relevant to CNS pathology after cell infiltration are largely undefined. Myelin-oligodendrocyte-glycoprotein (MOG-induced experimental autoimmune encephalomyelitis (EAE is an animal model of multiple sclerosis (MS, a chronic autoimmune disease of the CNS that results in disability. To assess genes that are involved in encephalitogenicity and subsequent tissue damage mediated by CNS-infiltrating cells, we performed a DNA microarray analysis from cells derived from lymph nodes and eluted from CNS in LEW.1AV1 (RT1av1 rats immunized with MOG 91-108. The data was compared to immunizations with adjuvant alone or naive rats and to immunizations with the immunogenic but not encephalitogenic MOG 73-90 peptide. Here, we show involvement of Cd38, Cxcr4 and Akt and confirm these findings by the use of Cd38-knockout (B6.129P2-Cd38tm1Lnd/J mice, S1P-receptor modulation during EAE and quantitative expression analysis in individuals with MS. The hereby-defined underlying pathways indicate cellular activation and migration pathways mediated by G-protein-coupled receptors as crucial events in CNS tissue damage. These pathways can be further explored for novel therapeutic interventions.

Monoglyceride-based self-assembling copolymers as carriers for poorly water-soluble drugs.

Science.gov (United States)

Rouxhet, L; Dinguizli, M; Latere Dwan'isa, J P; Ould-Ouali, L; Twaddle, P; Nathan, A; Brewster, M E; Rosenblatt, J; Ariën, A; Préat, V

2009-12-01

To develop self-assembling polymers forming polymeric micelles and increasing the solubility of poorly soluble drugs, amphiphilic polymers containing a hydrophilic PEG moiety and a hydrophobic moiety derived from monoglycerides and polyethers were designed. The biodegradable copolymers were obtained via a polycondensation reaction of polyethylene glycol (PEG), monooleylglyceride (MOG) and succinic anhydride (SA). Polymers with molecular weight below 10,000 g/mol containing a minimum of 40 mol% PEG and a maximum of 10 mol% MOG self-assembled spontaneously in aqueous media upon gentle mixing. They formed particles with a diameter of 10 nm although some aggregation was evident. The critical micellar concentration varied between 3x10(-4) and 4x10(-3) g/ml, depending on the polymer. The cloud point (> or = 66 degrees C) and flocculation point (> or = 0.89 M) increased with the PEG chain length. At a 1% concentration, the polymers increased the solubility of poorly water-soluble drug candidates up to 500-fold. Drug solubility increased as a function of the polymer concentration. HPMC capsules filled with these polymers disintegrated and released model drugs rapidly. Polymer with long PEG chains had a lower cytotoxicity (MTT test) on Caco-2 cells. All of these data suggest that the object polymers, in particular PEG1000/MOG/SA (45/5/50) might be potential candidates for improving the oral biopharmaceutical performance of poorly soluble drugs.

Infectious Mononucleosis Triggers Generation of IgG Auto-Antibodies against Native Myelin Oligodendrocyte Glycoprotein.

Science.gov (United States)

Kakalacheva, Kristina; Regenass, Stephan; Wiesmayr, Silke; Azzi, Tarik; Berger, Christoph; Dale, Russell C; Brilot, Fabienne; Münz, Christian; Rostasy, Kevin; Nadal, David; Lünemann, Jan D

2016-02-12

A history of infectious mononucleosis (IM), symptomatic primary infection with the Epstein Barr virus, is associated with the development of autoimmune diseases and increases the risk to develop multiple sclerosis. Here, we hypothesized that immune activation during IM triggers autoreactive immune responses. Antibody responses towards cellular antigens using a HEp-2 based indirect immunofluorescence assay and native myelin oligodendrocyte glycoprotein (MOG) using a flow cytometry-based assay were determined in 35 patients with IM and in 23 control subjects. We detected frequent immunoglobulin M (IgM) reactivity to vimentin, a major constituent of the intermediate filament family of proteins, in IM patients (27/35; 77%) but rarely in control subjects (2/23; 9%). IgG autoantibodies binding to HEp-2 cells were absent in both groups. In contrast, IgG responses to native MOG, present in up to 40% of children with inflammatory demyelinating diseases of the central nervous system (CNS), were detectable in 7/35 (20%) patients with IM but not in control subjects. Normalization of anti-vimentin IgM levels to increased total IgM concentrations during IM resulted in loss of significant differences for anti-vimentin IgM titers. Anti-MOG specific IgG responses were still detectable in a subset of three out of 35 patients with IM (9%), even after normalization to increased total IgG levels. Vimentin-specific IgM and MOG-specific IgG responses decreased following clinical resolution of acute IM symptoms. We conclude from our data that MOG-specific memory B cells are activated in subset of patients with IM.

Proposal of a Modelling of the Innovation Process in an International Manufacturing Company

Directory of Open Access Journals (Sweden)

Pauline Lacom

2017-07-01

Full Text Available Nowadays, to cope with the competition, and to ensure the durability of their activities, companies have to be able to innovate. Manufacturing companies operating in a B2B market often perceive innovation as a technological result. However, innovation is often more characterized as a process. The needs of the users, and not only the technology, can achieve innovation. In this context, our paper intends to determine how to involve better the users in the innovation process of an international manufacturing company, which is, according to us, representative of the current manufacturing companies. The aim of our research paper is to help manufacturing companies to manage innovation led by users, and to implement their innovation process so that they will be able to set up specific tools for each action of the process. The study proposes a diagram-based language Structured Analysis and Design Technique (SADT that is based on the normative guide FD X50-271 of the French national organization for standardization (AFNOR. The SADT model we propose usefully complements this guide, to make the innovation process more understandable, practical and operational, for manufacturing companies, which are often helpless when faced with the subject. A critical analysis of the model we propose completed in a manufacturing company through semi-structured interviews of the innovation team and questionnaire for all the employees shows the application of the model in the company.

QAM: PROPOSED MODEL FOR QUALITY ASSURANCE IN CBSS

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Latika Kharb

2015-08-01

Full Text Available Component-based software engineering (CBSE / Component-Based Development (CBD lays emphasis on decomposition of the engineered systems into functional or logical components with well-defined interfaces used for communication across the components. Component-based software development approach is based on the idea to develop software systems by selecting appropriate off-the-shelf components and then to assemble them with a well-defined software architecture. Because the new software development paradigm is much different from the traditional approach, quality assurance for component-based software development is a new topic in the software engineering research community. Because component-based software systems are developed on an underlying process different from that of the traditional software, their quality assurance model should address both the process of components and the process of the overall system. Quality assurance for component-based software systems during the life cycle is used to analyze the components for achievement of high quality component-based software systems. Although some Quality assurance techniques and component based approach to software engineering have been studied, there is still no clear and well-defined standard or guidelines for component-based software systems. Therefore, identification of the quality assurance characteristics, quality assurance models, quality assurance tools and quality assurance metrics, are under urgent need. As a major contribution in this paper, I have proposed QAM: Quality Assurance Model for component-based software development, which covers component requirement analysis, component development, component certification, component architecture design, integration, testing, and maintenance.

Two-Dimensional Model Test Study of New Western Breakwater Proposal for Port of Hanstholm

OpenAIRE

Eldrup, Mads Røge; Andersen, Thomas Lykke

2016-01-01

The present report presents results from a two-dimensional model test study carried out at Aalborg University in December 2016 with the proposed trunk section for the new western breakwater in Port of Hanstholm. The objectives of the model tests were to study the stability of the armour layer, toe erosion, overtopping and transmission. The scale used for the model tests was 1:61.5. Unless otherwise specified all values given in this report are prototype values converted from the model to prot...

Two-Dimensional Model Test Study of New Western Breakwater Proposal for Port of Hanstholm

DEFF Research Database (Denmark)

Eldrup, Mads Røge; Andersen, Thomas Lykke

The present report presents results from a two-dimensional model test study carried out at Aalborg University in December 2016 with the proposed trunk section for the new western breakwater in Port of Hanstholm. The objectives of the model tests were to study the stability of the armour layer, toe...... erosion, overtopping and transmission. The scale used for the model tests was 1:61.5. Unless otherwise specified all values given in this report are prototype values converted from the model to prototype according to the Froude model law....

Boundary methods for mode estimation

Science.gov (United States)

Pierson, William E., Jr.; Ulug, Batuhan; Ahalt, Stanley C.

1999-08-01

This paper investigates the use of Boundary Methods (BMs), a collection of tools used for distribution analysis, as a method for estimating the number of modes associated with a given data set. Model order information of this type is required by several pattern recognition applications. The BM technique provides a novel approach to this parameter estimation problem and is comparable in terms of both accuracy and computations to other popular mode estimation techniques currently found in the literature and automatic target recognition applications. This paper explains the methodology used in the BM approach to mode estimation. Also, this paper quickly reviews other common mode estimation techniques and describes the empirical investigation used to explore the relationship of the BM technique to other mode estimation techniques. Specifically, the accuracy and computational efficiency of the BM technique are compared quantitatively to the a mixture of Gaussian (MOG) approach and a k-means approach to model order estimation. The stopping criteria of the MOG and k-means techniques is the Akaike Information Criteria (AIC).

Proposal for Classifying the Severity of Speech Disorder Using a Fuzzy Model in Accordance with the Implicational Model of Feature Complexity

Science.gov (United States)

Brancalioni, Ana Rita; Magnago, Karine Faverzani; Keske-Soares, Marcia

2012-01-01

The objective of this study is to create a new proposal for classifying the severity of speech disorders using a fuzzy model in accordance with a linguistic model that represents the speech acquisition of Brazilian Portuguese. The fuzzy linguistic model was run in the MATLAB software fuzzy toolbox from a set of fuzzy rules, and it encompassed…

Progressive microstructural changes of the occipital cortex in Huntington's disease.

Science.gov (United States)

Odish, Omar F F; Reijntjes, Robert H A M; van den Bogaard, Simon J A; Roos, Raymund A C; Leemans, Alexander

2018-02-28

In this study we longitudinally investigated the rate of microstructural alterations in the occipital cortex in different stages of Huntington's disease (HD) by applying an automated atlas-based approach to diffusion MRI data. Twenty-two premanifest (preHD), 10 early manifest HD (early HD) and 24 healthy control subjects completed baseline and two year follow-up scans. The preHD group was stratified based on the predicted years to disease onset into a far (preHD-A) and near (preHD-B) to disease onset group. Clinical and behavioral measures were collected per assessment time point. An automated atlas-based DTI analysis approach was used to obtain the mean, axial and radial diffusivities of the occipital cortex. We found that the longitudinal rate of diffusivity change in the superior occipital gyrus (SOG), middle occipital gyrus (MOG), and inferior occipital gyrus (IOG) was significantly higher in early HD compared to both preHD and controls (all p's ≤ 0.005), which can be interpreted as an increased rate of microstructural degeneration. Furthermore, the change rate in the diffusivity of the MOG could significantly discriminate between preHD-B compared to preHD-A and the other groups (all p's ≤ 0.04). Finally, we found an inverse correlation between the Stroop Word Reading task and diffusivities in the SOG and MOG (all p's ≤ 0.01). These findings suggest that measures obtained from the occipital cortex can serve as sensitive longitudinal biomarkers for disease progression in preHD-B and early HD. These could in turn be used to assess potential effects of proposed disease modifying therapies.

Modeling fault rupture hazard for the proposed repository at Yucca Mountain, Nevada

International Nuclear Information System (INIS)

Coppersmith, K.J.; Youngs, R.R.

1992-01-01

In this paper as part of the Electric Power Research Institute's High Level Waste program, the authors have developed a preliminary probabilistic model for assessing the hazard of fault rupture to the proposed high level waste repository at Yucca Mountain. The model is composed of two parts: the earthquake occurrence model that describes the three-dimensional geometry of earthquake sources and the earthquake recurrence characteristics for all sources in the site vicinity; and the rupture model that describes the probability of coseismic fault rupture of various lengths and amounts of displacement within the repository horizon 350 m below the surface. The latter uses empirical data from normal-faulting earthquakes to relate the rupture dimensions and fault displacement amounts to the magnitude of the earthquake. using a simulation procedure, we allow for earthquake occurrence on all of the earthquake sources in the site vicinity, model the location and displacement due to primary faults, and model the occurrence of secondary faulting in conjunction with primary faulting

Proposed Model for Integrating RAMS Method in the Design Process in Construction

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Saad Al-Jibouri

2010-05-01

Full Text Available There is a growing trend in the Netherlands for outsourcing public construction activities to the private sector through the use of integrated contracts. There is also an increasing emphasis from public clients on the use of RAMS and life cycle costing (LCC in the design process of infrastructural projects to improve the performance of designed systems and optimize the project cost. RAMS is an acronym for `reliability, availability, maintainability and safety' and represents a collection of techniques to provide predictions of the performance targets of the required system. Increasingly, RAMS targets are being specified in invitation to tender or contract documents and the parties responsible for the design are required to provide evidence of its application in their design. Recent evidence from practice, complemented with a literature study, has shown that the knowledge and application of RAMS in infrastructural designs are in their infancy compared with other industrial sectors and many designers in construction do not have the necessary knowledge and experience to apply it. This paper describes a proposed model for the integration of RAMS and LCC into the design process in construction. A variation of the model for the application of RAMS in `design, build, finance and maintain' (DBFM contracts that include maintenance requirements is also proposed. The two models involve providing guidelines to simplify the application of RAMs by the designers. The model has been validated for its practicality and usefulness during a workshop by experienced designers. DOI: 10.3763/aedm.2008.0100 Published in the Journal AEDM - Volume 5, Number 4, 2009 , pp. 179-192(14

Molecule@MOF: A New Class of Opto-electronic Materials.

Energy Technology Data Exchange (ETDEWEB)

Talin, Albert Alec [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Reese E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Spataru, Dan Catalin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Leonard, Francois Leonard [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); He, Yuping [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Foster, Michael E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Allendorf, Mark D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stavila, Vitalie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hopkins, Patrick E. [Univ. of Virginia, Charlottesville, VA (United States)

2017-09-01

Metal organic frameworks (MOFs) are extended, nanoporous crystalline compounds consisting of metal ions interconnected by organic ligands. Their synthetic versatility suggest a disruptive class of opto - electronic materials with a high degree of electrical tunability and without the property - degrading disorder of organic conductors. In this project we determined the factors controlling charge and energy transport in MOFs and evaluated their potential for thermoelectric energy conversion. Two strategies for a chieving electronic conductivity in MOFs were explored: 1) using redox active 'guest' molecules introduced into the pores to dope the framework via charge - transfer coupling (Guest@MOF), 2) metal organic graphene analogs (MOGs) with dispersive band structur es arising from strong electronic overlap between the MOG metal ions and its coordinating linker groups. Inkjet deposition methods were developed to facilitate integration of the guest@MOF and MOG materials into practical devices.

A note on power and sample size calculations for the Kruskal-Wallis test for ordered categorical data.

Science.gov (United States)

Fan, Chunpeng; Zhang, Donghui

2012-01-01

Although the Kruskal-Wallis test has been widely used to analyze ordered categorical data, power and sample size methods for this test have been investigated to a much lesser extent when the underlying multinomial distributions are unknown. This article generalizes the power and sample size procedures proposed by Fan et al. ( 2011 ) for continuous data to ordered categorical data, when estimates from a pilot study are used in the place of knowledge of the true underlying distribution. Simulations show that the proposed power and sample size formulas perform well. A myelin oligodendrocyte glycoprotein (MOG) induced experimental autoimmunce encephalomyelitis (EAE) mouse study is used to demonstrate the application of the methods.

Stress, autonomic imbalance, and the prediction of metabolic risk: A model and a proposal for research.

Science.gov (United States)

Wulsin, Lawson; Herman, James; Thayer, Julian F

2018-03-01

Devising novel prevention strategies for metabolic disorders will depend in part on the careful elucidation of the common pathways for developing metabolic risks. The neurovisceral integration model has proposed that autonomic imbalance plays an important role in the pathway from acute and chronic stress to cardiovascular disease. Though generally overlooked by clinicians, autonomic imbalance (sympathetic overactivity and/or parasympathetic underactivity) can be measured and modified by methods that are available in primary care. This review applies the neurovisceral integration concept to the clinical setting by proposing that autonomic imbalance plays a primary role in the development of metabolic risks. We present a testable model, a systematic review of the evidence in support of autonomic imbalance as a predictor for metabolic risks, and specific approaches to test this model as a guide to future research on the role of stress in metabolic disorders. We propose that autonomic imbalance deserves consideration by researchers, clinicians, and policymakers as a target for early interventions to prevent metabolic disorders. Published by Elsevier Ltd.

A proposed strategy for the validation of ground-water flow and solute transport models

International Nuclear Information System (INIS)

Davis, P.A.; Goodrich, M.T.

1991-01-01

Ground-water flow and transport models can be thought of as a combination of conceptual and mathematical models and the data that characterize a given system. The judgment of the validity or invalidity of a model depends both on the adequacy of the data and the model structure (i.e., the conceptual and mathematical model). This report proposes a validation strategy for testing both components independently. The strategy is based on the philosophy that a model cannot be proven valid, only invalid or not invalid. In addition, the authors believe that a model should not be judged in absence of its intended purpose. Hence, a flow and transport model may be invalid for one purpose but not invalid for another. 9 refs

Information Systems Success In Public Administration: Proposal For An Exploratory Model

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Deyvison de Lima Oliveira

2015-12-01

Full Text Available Investments in Information Systems (IS have been significantly increasing and hence the relevance of the studies on the IS success is persistent. Delone and Mclean (2003 developed an IS successful model which is a benchmark for researches in the area, however, in the perspective of the public sector, studies are still rare. In this research it was sought to propose an exploratory model of successful IS in public administration, from the identification of each construct items of the Delone and McLean (2003 original model, through multiple case studies in three Municipalities and a Town Hall of the Southern Cone of Rondônia state, in Brazil. Based on the empirical research, it was found that the IS success factors in municipal public administration are close to those factors indicated in the reviewed literature, however, showing some particularities of the public sector. A model of successful factors and items of IS, from the confrontation between literature and empirical data, is presented in the end of this work.

The ERICAM model: a proposal for amelioration of nuclear liability by funding on the capital markets

International Nuclear Information System (INIS)

Tyran, J.R.

1995-01-01

The ERICAM model (Environmental Risk Internalization through Capital Markets) includes the capital markets as a source contributing to the coverage of risks due to nuclear activites, thus enhancing the effectiveness and functions of the nuclear liability law. The model proposed will allow higher amounts for compensation and will increase financial security, flow of information, and efficient use of resources. The implementation of the model can be achieved on the financing side by issuing Nuke bonds, linking accident-specific options to government bonds. This will essentially increase the risk coverage compared to present means, and will be a pin-pointed addition to the existing layer system. There are three institutions proposed to act as mediators in the implementation of the model: A government authority to supervise the trade in Nuke bonds. Risk-bearing associations in oder to enhance the model's efficiency, and to reduce transaction costs. Rating agencies that will reduce the expenditure for information. (orig./HP) [de

A proposed agglomerate model for oxygen reduction in the catalyst layer of proton exchange membrane fuel cells

International Nuclear Information System (INIS)

Zhang, Xiaoxian; Gao, Yuan; Ostadi, Hossein; Jiang, Kyle; Chen, Rui

2014-01-01

Highlights: • We developed a new agglomerate model to describe oxygen reduction reaction. • We showed how to calculate the model parameters from catalyst layer structure. • We verified the agglomerate model. - Abstract: Oxygen diffusion and reduction in the catalyst layer of PEM fuel cell is an important process in fuel cell modelling, but models able to link the reduction rate to catalyst-layer structure are lack; this paper makes such an effort. We first link the average reduction rate over the agglomerate within a catalyst layer to a probability that an oxygen molecule, which is initially on the agglomerate surface, will enter and remain in the agglomerate at any time in the absence of any electrochemical reaction. We then propose a method to directly calculate distribution function of this probability and apply it to two catalyst layers with contrasting structures. A formula is proposed to describe these calculated distribution functions, from which the agglomerate model is derived. The model has two parameters and both can be independently calculated from catalyst layer structures. We verify the model by first showing that it is an improvement and able to reproduce what the spherical model describes, and then testing it against the average oxygen reductions directly calculated from pore-scale simulations of oxygen diffusion and reaction in the two catalyst layers. The proposed model is simple, but significant as it links the average oxygen reduction to catalyst layer structures, and its two parameters can be directly calculated rather than by calibration

PROPOSED SUITE OF MODELS FOR ESTIMATING DOSE RESULTING FROM EXPOSURES BY THE DERMAL ROUTE

Science.gov (United States)

Recent risk assessment guidance emphasizes consideration of mechanistic factors for influencing disposition of a toxicant. To incorporate mechanistic information into risk assessment, a suite of models is proposed for use in characterizing and quantifying dosimetry of toxic age...

Proposal for a model for competitiveness analysis in environmental sustainability in automotive segment companies

Directory of Open Access Journals (Sweden)

Luís Henrique Rodrigues

2018-06-01

Full Text Available The competitive landscape for companies has been changing over time, featuring an increase in competitiveness in cost, quality, reliability, agility and more recently by a concern for environmental and social factors. This work aims to propose an exploratory analysis model to evaluate companies’ sustainability competitiveness. The model proposes the grouping of companies into clusters, ranking them according to the adoption of lean manufacturing practices, environmental management and human resources, and allocating them into quadrants according to the higher or lower production of waste in their manufacturing processes. The adherence to the model is made with a sample of automotive segment companies (auto parts and motor vehicle manufacturers. The work is classified as one of a practical nature, exploratory, qualitative, and using the survey method. The conclusion that 37.5% of auto parts companies are grouped into clusters that lead to the reduction of waste, with practices in lean manufacturing and environmental management which adjust to competitive factors in the sustainability of motor vehicle manufacturers, is noteworthy.

Proposed Core Competencies and Empirical Validation Procedure in Competency Modeling: Confirmation and Classification.

Science.gov (United States)

Baczyńska, Anna K; Rowiński, Tomasz; Cybis, Natalia

2016-01-01

Competency models provide insight into key skills which are common to many positions in an organization. Moreover, there is a range of competencies that is used by many companies. Researchers have developed core competency terminology to underline their cross-organizational value. The article presents a theoretical model of core competencies consisting of two main higher-order competencies called performance and entrepreneurship. Each of them consists of three elements: the performance competency includes cooperation, organization of work and goal orientation, while entrepreneurship includes innovativeness, calculated risk-taking and pro-activeness. However, there is lack of empirical validation of competency concepts in organizations and this would seem crucial for obtaining reliable results from organizational research. We propose a two-step empirical validation procedure: (1) confirmation factor analysis, and (2) classification of employees. The sample consisted of 636 respondents (M = 44.5; SD = 15.1). Participants were administered a questionnaire developed for the study purpose. The reliability, measured by Cronbach's alpha, ranged from 0.60 to 0.83 for six scales. Next, we tested the model using a confirmatory factor analysis. The two separate, single models of performance and entrepreneurial orientations fit quite well to the data, while a complex model based on the two single concepts needs further research. In the classification of employees based on the two higher order competencies we obtained four main groups of employees. Their profiles relate to those found in the literature, including so-called niche finders and top performers. Some proposal for organizations is discussed.

Proposal for intake model for workers at IPEN-CNEN/SP who handle 131 I

International Nuclear Information System (INIS)

Todo, A.S.; Potiens Junior, A.J.; Gaburo, J.C.; Sanches, M.P.; Oliveira, E.M.

1997-01-01

The intake model for the two groups of workers at IPEN-CNEN/SP is presented. They handle iodine compounds during the processing of irradiated targets and at labeling of radiopharmaceutical compounds. The intake model for the workers are proposed from the knowledge of the activities carried out in the plant and the internal monitoring program of the workers. In this study, the intake is considered to be taken uniformly during the days of major activities carried out by the workers. In practice, the application of this model has be shown suitable, for the studied groups

Knowledge Management Implementation at the Women’s Branch of the Institute of Public Administration in Saudi Arabia: A Proposed Model

Directory of Open Access Journals (Sweden)

Eiman Saud Abokhodiar

2014-05-01

Full Text Available This article aims to introduce a proposed model of knowledge management implementation at the Women’s Branch of the Institute of Public Administration (WIPA. The model was built after a review and analysis of literature related to knowledge management implementation in higher education institutions. The research includes three sections. The first section deals with a theoretical framework of knowledge management, including a knowledge management definition, components of knowledge management systems, an academic knowledge framework, an organizational knowledge framework, and processes of knowledge management. The second section reviews and discusses the proposed model of knowledge management implementation at WIPA. Finally, the article concludes with a discussion of the success factors and expected barriers to the proposed model.

Dynamic risk assessment method – a proposal for assessing risk in water supply system / Metoda dynamicznego szacowania ryzyka – propozycja oceny ryzyka w systemie zaopatrzenia wody

OpenAIRE

Fortmann-Roe Scott; Iwanejko Ryszarda; Wójcik Włodzimierz

2015-01-01

Dynamika Systemów jest metodologią modelowania i analizy złożonych systemów. Taki złożony system może być charakteryzowany przez wzajemne proste połączenia elementów oraz istniejące sprzężenia zwrotne. Przeprowadzenie oceny ryzyka przy modelowaniu Systemów Dynamicznych jest trudnym wyzwaniem. Chociaż w niektórych przypadkach, uzyskane za pomocą symulacji serie wyników mogą się wydawać przypadkowe, to jednak często istnieje wysoki stopień autokorelacji między tymi seriami wynikający z istnieni...

Corporate Social Responsibility And Islamic Business Organizations: A Proposed Model

Directory of Open Access Journals (Sweden)

Rusnah Muhamad

2008-01-01

Full Text Available The issue of corporate social responsibility (CSR has been of growing concern among business communities in recent years. Various corporate leaders maintain that business is considered to contribute fully to the society if it is effi cient, profi table and socially responsible. Islam is considered as addin (a way of life, thus, providing comprehensive guidelines in every aspects of the believers’ life. It is the aim of this paper to propose an Islamic model of corporate social responsibility based on human relationships with the God (hablun min’Allah; with other fellow human being (hablun min’an-nas and with the environment.Keywords : Corporate Social Responsibility, Islamic Business Organization

Proposal of Constraints Analysis Method Based on Network Model for Task Planning

Science.gov (United States)

Tomiyama, Tomoe; Sato, Tatsuhiro; Morita, Toyohisa; Sasaki, Toshiro

Deregulation has been accelerating several activities toward reengineering business processes, such as railway through service and modal shift in logistics. Making those activities successful, business entities have to regulate new business rules or know-how (we call them ‘constraints’). According to the new constraints, they need to manage business resources such as instruments, materials, workers and so on. In this paper, we propose a constraint analysis method to define constraints for task planning of the new business processes. To visualize each constraint's influence on planning, we propose a network model which represents allocation relations between tasks and resources. The network can also represent task ordering relations and resource grouping relations. The proposed method formalizes the way of defining constraints manually as repeatedly checking the network structure and finding conflicts between constraints. Being applied to crew scheduling problems shows that the method can adequately represent and define constraints of some task planning problems with the following fundamental features, (1) specifying work pattern to some resources, (2) restricting the number of resources for some works, (3) requiring multiple resources for some works, (4) prior allocation of some resources to some works and (5) considering the workload balance between resources.

Space-Time Uncertainty and Cosmology: a Proposed Quantum Model of the Universe [ 245Kb

Directory of Open Access Journals (Sweden)

Tosto S.

2013-10-01

Full Text Available The paper introduces a cosmological model of the quantum universe. The aim of the model is (i to identify the possible mechanism that governs the matter/antimatter ratio existing in the universe and concurrently to propose (ii a reasonable growth mechanism of the universe and (iii a possible explanation of the dark energy. The concept of timespace uncertainty, on which is based the present quantum approach, has been proven able to bridge quantum mechanics and relativity.

"The Actualized Neurosurgeon": A Proposed Model of Surgical Resident Development.

Science.gov (United States)

Lipsman, Nir; Khan, Osaama; Kulkarni, Abhaya V

2017-03-01

Modern neurosurgical training is both physically and emotionally demanding, posing significant challenges, new and old, to residents as well as programs attempting to train safe, competent surgeons. Models to describe resident development, such as the Accreditation Council for Graduate Medical Education competencies and milestones, address the acquisition of specific skills but largely ignore the stresses and pressures unique to each stage of resident training. We propose an alternative model of resident development adapted from the developmental psychology literature. Our model identifies the challenges that must be met at each stage of junior, intermediate, and senior and chief residency, leading ultimately to an "actualized" neurosurgeon (i.e., one who has maximized his or her potential). Failure to overcome any 1 of these challenges can lead to specific long-lasting consequences, including regret, identity crisis, incompetence, and bitterness. In contrast, the actualized surgeon is one who has successfully acquired the virtues of hope, will, purpose, fidelity, productivity, leadership, competence, and wisdom. The actualized surgeon not only functions safely, confidently, and professionally, but also successfully navigates the challenges of residency and emerges from them having fulfilled his or her maximal potential. This developmental perspective provides an individualized description of healthy surgical development. Our model allows programs to identify the basis for residents who fail to progress, counsel residents during their training, and perhaps help identify resident candidates who are better prepared to meet the developmental challenges of residency training. Copyright © 2016 Elsevier Inc. All rights reserved.

Proposal of custom made wrist orthoses based on 3D modelling and 3D printing.

Science.gov (United States)

Abreu de Souza, Mauren; Schmitz, Cristiane; Marega Pinhel, Marcelo; Palma Setti, Joao A; Nohama, Percy

2017-07-01

Accessibility to three-dimensional (3D) technologies, such as 3D scanning systems and additive manufacturing (like 3D printers), allows a variety of 3D applications. For medical applications in particular, these modalities are gaining a lot of attention enabling several opportunities for healthcare applications. The literature brings several cases applying both technologies, but none of them focus on the spreading of how this technology could benefit the health segment. This paper proposes a new methodology, which employs both 3D modelling and 3D printing for building orthoses, which could better fit the demands of different patients. Additionally, there is an opportunity for sharing expertise, as it represents a trendy in terms of the maker-movement. Therefore, as a result of the proposed approach, we present a case study based on a volunteer who needs an immobilization orthosis, which was built for exemplification of the whole process. This proposal also employs freely available 3D models and software, having a strong social impact. As a result, it enables the implementation and effective usability for a variety of built to fit solutions, hitching useful and smarter technologies for the healthcare sector.

A self-report measure for the ICD-11 dimensional trait model proposal: The personality inventory for ICD-11.

Science.gov (United States)

Oltmanns, Joshua R; Widiger, Thomas A

2018-02-01

Proposed for the 11th edition of the World Health Organization's International Classification of Diseases (ICD-11) is a dimensional trait model for the classification of personality disorder (Tyrer, Reed, & Crawford, 2015). The ICD-11 proposal consists of 5 broad domains: negative affective, detachment, dissocial, disinhibition, and anankastic (Mulder, Horwood, Tyrer, Carter, & Joyce, 2016). Several field trials have examined this proposal, yet none has included a direct measure of the trait model. The purpose of the current study was to develop and provide initial validation for the Personality Inventory for ICD-11 (PiCD), a self-report measure of this proposed 5-domain maladaptive trait model. Item selection and scale construction proceeded through 3 initial data collections assessing potential item performance. Two subsequent studies were conducted for scale validation. In Study 1, the PiCD was evaluated in a sample of 259 MTurk participants (who were or had been receiving mental health treatment) with respect to 2 measures of general personality structure: The Eysenck Personality Questionnaire-Revised and the 5-Dimensional Personality Test. In Study 2, the PiCD was evaluated in an additional sample of 285 participants with respect to 2 measures of maladaptive personality traits: The Personality Inventory for DSM-5 and the Computerized Adaptive Test for Personality Disorders. Study 3 provides an item-level exploratory structural equation model with the combined samples from Studies 1 and 2. The results are discussed with respect to the validity of the measure and the potential benefits for future research in having a direct, self-report measure of the ICD-11 trait proposal. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

APC-PC Combined Scheme in Gilbert Two State Model: Proposal and Study

Science.gov (United States)

Bulo, Yaka; Saring, Yang; Bhunia, Chandan Tilak

2017-04-01

In an automatic repeat request (ARQ) scheme, a packet is retransmitted if it gets corrupted due to transmission errors caused by the channel. However, an erroneous packet may contain both erroneous bits and correct bits and hence it may still contain useful information. The receiver may be able to combine this information from multiple erroneous copies to recover the correct packet. Packet combining (PC) is a simple and elegant scheme of error correction in transmitted packet, in which two received copies are XORed to obtain the bit location of erroneous bits. Thereafter, the packet is corrected by bit inversion of bit located as erroneous. Aggressive packet combining (APC) is a logic extension of PC primarily designed for wireless communication with objective of correcting error with low latency. PC offers higher throughput than APC, but PC does not correct double bit errors if occur in same bit location of erroneous copies of the packet. A hybrid technique is proposed to utilize the advantages of both APC and PC while attempting to remove the limitation of both. In the proposed technique, applications of APC-PC on Gilbert two state model has been studied. The simulation results show that the proposed technique offers better throughput than the conventional APC and lesser packet error rate than PC scheme.

A proposed model of psychodynamic psychotherapy linked to Erik Erikson's eight stages of psychosocial development.

Science.gov (United States)

Knight, Zelda Gillian

2017-09-01

Just as Freud used stages of psychosexual development to ground his model of psychoanalysis, it is possible to do the same with Erik Erikson's stages of development with regards to a model of psychodynamic psychotherapy. This paper proposes an eight-stage model of psychodynamic psychotherapy linked to Erik Erikson's eight stages of psychosocial development. Various suggestions are offered. One such suggestion is that as each of Erikson's developmental stages is triggered by a crisis, in therapy it is triggered by the client's search. The resolution of the search often leads to the development of another search, which implies that the therapy process comprises a series of searches. This idea of a series of searches and resolutions leads to the understanding that identity is developmental and therapy is a space in which a new sense of identity may emerge. The notion of hope is linked to Erikson's stage of Basic Trust and the proposed model of therapy views hope and trust as essential for the therapy process. Two clinical vignettes are offered to illustrate these ideas. Psychotherapy can be approached as an eight-stage process and linked to Erikson's eight stages model of development. Psychotherapy may be viewed as a series of searches and thus as a developmental stage resolution process, which leads to the understanding that identity is ongoing throughout the life span. Copyright © 2017 John Wiley & Sons, Ltd.

A molecular mechanism for diacylglycerol-mediated promotion of negative caloric balance

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Yanai H

2009-12-01

Full Text Available Hidekatsu Yanai1,2, Yoshiharu Tomono3, Kumie Ito1,2, Yuji Hirowatari4, Hiroshi Yoshida1,5, Norio Tada1,21Department of Internal Medicine, 2Institute of Clinical Medicine and Research, 3Department of Nutrition, 5Department of Laboratory Medicine, Jikei University School of Medicine, chiba, Japan; 4Bioscience Division, Tosoh Corporation, Kanagawa, JapanAims: A substitution of diacylglycerol (DAG oil for triacylglycerol (TAG oil in diet has been reported to reduce body fat and body weight, possibly by increasing postprandial energy expenditure (EE. We have previously studied plasma serotonin, which increases EE and exists in the small intestine, in individuals who ingested TAG and DAG oil, and found that DAG ingestion elevates plasma serotonin levels by about 50% compared with TAG ingestion. We studied the molecular mechanisms for DAG-mediated increase in serotonin and EE.Methods: We studied effects of 1-monoacylglycerol and 2-monoacylglycerol, distinct digestive products of DAG and TAG, respectively, on serotonin release from the Caco-2 cells (the human intestinal cell line, n = 8. Further, we studied effects of 1- and 2-monoacylglycerol, and serotonin on expression of mRNA associated with β-oxidation, FA metabolism, and thermogenesis, in the Caco-2 cells (n = 5.Results: 1-monoacylglycerol (100 µM 1-monooleyl glycerol [1-MOG] significantly increased serotonin release from the Caco-2 cells compared with 2-monoacylglycerol (100 µM 2-MOG by 36.6%. Expression of mRNA of acyl-CoA oxidase (ACO, fatty acid translocase (FAT, and uncoupling protein-2 (UCP-2 were significantly higher in 100 µM 1-MOG-treated Caco-2 cells than 100 µM 2-MOG-treated cells by 12.8%, 23.7%, and 35.1%, respectively. Further, expression of mRNA of ACO, medium-chain acyl-CoA dehydrogenase, FAT, and UCP-2 were significantly elevated in serotonin (400 nM-treated Caco-2 cells compared with cells incubated without serotonin by 28.7%, 30.1%, and 39.2%, respectively.Conclusions: Our

Proposal of the mathematical model of the aquifer for interpretation of measurements of natural isotopes in the water

International Nuclear Information System (INIS)

Nawalany, M.

1975-01-01

Mathematical models applied in isotope hydrology are presented in the paper. The most commonly used deterministic models are discussed in the first part of the paper including the piston flow and good mixing models. The model of nonideal mixing is introduced by the author into the hydrological considerations. This model is a generalization of the good mixing model and allows for different processes of mixing of natural isotopes in waters of hydrological systems. The most important stochastic model i.e. the dispersive model is discussed too. The ''three-velocities'' model is proposed the first time by the author. The ''three-velocities'' model differs from the other ones in following properties: it includes finite flow velocity of the tracer particles, it takes into account the presence of stagnant water, it satisfied the law of fluid continuity, it is convergent to the piston-flow model in limit. However the model proposed describes dispersion phenomenon and satisfied the tracer conservation law (i.e. standarization) - the two properties characteristic of all the models. The author's strong belief is that the user (hydrologist) having at his disposal given below review of the models will be able to choose the most adequate model in given hydrological conditions. (author)

Child-Labor Proposal Eyes Private Model

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Cech, Scott J.

2007-01-01

Proposed child-labor-rule changes--the most ambitious in 30 years--would carve out a permanent exemption to U.S. Department of Labor regulations for the work-study program run by a national network of Roman Catholic high schools. The program is a requirement of the Chicago-based Cristo Rey Network, which now has 12 high schools around the country…

Effective Solar Indices for Ionospheric Modeling: A Review and a Proposal for a Real-Time Regional IRI

Science.gov (United States)

Pignalberi, A.; Pezzopane, M.; Rizzi, R.; Galkin, I.

2018-01-01

The first part of this paper reviews methods using effective solar indices to update a background ionospheric model focusing on those employing the Kriging method to perform the spatial interpolation. Then, it proposes a method to update the International Reference Ionosphere (IRI) model through the assimilation of data collected by a European ionosonde network. The method, called International Reference Ionosphere UPdate (IRI UP), that can potentially operate in real time, is mathematically described and validated for the period 9-25 March 2015 (a time window including the well-known St. Patrick storm occurred on 17 March), using IRI and IRI Real Time Assimilative Model (IRTAM) models as the reference. It relies on foF2 and M(3000)F2 ionospheric characteristics, recorded routinely by a network of 12 European ionosonde stations, which are used to calculate for each station effective values of IRI indices IG_{12} and R_{12} (identified as IG_{{12{eff}}} and R_{{12{eff}}}); then, starting from this discrete dataset of values, two-dimensional (2D) maps of IG_{{12{eff}}} and R_{{12{eff}}} are generated through the universal Kriging method. Five variogram models are proposed and tested statistically to select the best performer for each effective index. Then, computed maps of IG_{{12{eff}}} and R_{{12{eff}}} are used in the IRI model to synthesize updated values of foF2 and hmF2. To evaluate the ability of the proposed method to reproduce rapid local changes that are common under disturbed conditions, quality metrics are calculated for two test stations whose measurements were not assimilated in IRI UP, Fairford (51.7°N, 1.5°W) and San Vito (40.6°N, 17.8°E), for IRI, IRI UP, and IRTAM models. The proposed method turns out to be very effective under highly disturbed conditions, with significant improvements of the foF2 representation and noticeable improvements of the hmF2 one. Important improvements have been verified also for quiet and moderately disturbed

Organizational intellectual capital and the role of the nurse manager: A proposed conceptual model.

Science.gov (United States)

Gilbert, Jason H; Von Ah, Diane; Broome, Marion E

Nurse managers must leverage both the human capital and social capital of the teams they lead in order to produce quality outcomes. Little is known about the relationship between human capital and social capital and how these concepts may work together to produce organizational outcomes through leadership of nurses. The purpose of this article was to explore the concepts of human capital and social capital as they relate to nursing leadership in health care organizations. Specific aims included (a) to synthesize the literature related to human capital and social capital in leadership, (b) to refine the conceptual definitions of human capital and social capital with associated conceptual antecedents and consequences, and (c) to propose a synthesized conceptual model guiding further empirical research of social capital and human capital in nursing leadership. A systematic integrative review of leadership literature using criteria informed by Whittemore and Knafl (2005) was completed. CINAHL Plus with Full Text, Academic Search Premier, Business Source Premier, Health Business FullTEXT, MEDLINE, and PsychINFO databases were searched for the years 1995 to 2016 using terms "human capital," "social capital," and "management." Analysis of conceptual definitions, theoretical and conceptual models, antecedents and consequences, propositions or hypotheses, and empirical support for 37 articles fitting review criteria resulted in the synthesis of the proposed Gilbert Conceptual Model of Organizational Intellectual Capital. The Gilbert Conceptual Model of Organizational Intellectual Capital advances the propositions of human capital theory and social capital theory and is the first model to conceptualize the direct and moderating effects that nurse leaders have on the human capital and social capital of the teams they lead. This model provides a framework for further empirical study and may have implications for practice, organizational policy, and education related to nursing

PTSD's latent structure in Malaysian tsunami victims: assessing the newly proposed Dysphoric Arousal model.

Science.gov (United States)

Armour, Cherie; Raudzah Ghazali, Siti; Elklit, Ask

2013-03-30

The underlying latent structure of Posttraumatic Stress Disorder (PTSD) is widely researched. However, despite a plethora of factor analytic studies, no single model has consistently been shown as superior to alternative models. The two most often supported models are the Emotional Numbing and the Dysphoria models. However, a recently proposed five-factor Dysphoric Arousal model has been gathering support over and above existing models. Data for the current study were gathered from Malaysian Tsunami survivors (N=250). Three competing models (Emotional Numbing/Dysphoria/Dysphoric Arousal) were specified and estimated using Confirmatory Factor Analysis (CFA). The Dysphoria model provided superior fit to the data compared to the Emotional Numbing model. However, using chi-square difference tests, the Dysphoric Arousal model showed a superior fit compared to both the Emotional Numbing and Dysphoria models. In conclusion, the current results suggest that the Dysphoric Arousal model better represents PTSD's latent structure and that items measuring sleeping difficulties, irritability/anger and concentration difficulties form a separate, unique PTSD factor. These results are discussed in relation to the role of Hyperarousal in PTSD's on-going symptom maintenance and in relation to the DSM-5. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

The 'model omnitron' proposed experiment

International Nuclear Information System (INIS)

Sestero, A.

1997-05-01

The Model Omitron is a compact tokamak experiment which is designed by the Fusion Engineering Unit of ENEA and CITIF CONSORTIUM. The building of Model Omitron would allow for full testing of Omitron engineering, and partial testing of Omitron physics -at about 1/20 of the cost that has been estimated for the larger parent machine. In particular, due to the unusually large ohmic power densities (up to 100 times the nominal value in the Frascati FTU experiment), in Model Omitron the radial energy flux is reaching values comparable or higher than envisaged of the larger ignition experiments Omitron, Ignitor and Iter. Consequently, conditions are expected to occur at the plasma border in the scrape-off layer of Model Omitron, which are representative of the quoted larger experiments. Moreover, since all this will occur under ohmic heating alone, one will hopefully be able to derive an energy transport model fo the ohmic heating regime that is valid over a range of plasma parameters (in particular, of the temperature parameter) wider than it was possible before. In the Model Omitron experiment, finally - by reducing the plasma current and/or the toroidal field down to, say, 1/3 or 1/4 of the nominal values -additional topics can be tackled, such as: large safety-factor configurations (of interest for improving confinement), large aspect-ratio configurations (of interest for the investigation of advanced concepts in tokamaks), high beta (with RF heating -also of interest for the investigation of advanced concepts in tokamaks), long pulse discharges (of interest for demonstrating stationary conditions in the current profile)

Global model of zenith tropospheric delay proposed based on EOF analysis

Science.gov (United States)

Sun, Langlang; Chen, Peng; Wei, Erhu; Li, Qinzheng

2017-07-01

Tropospheric delay is one of the main error budgets in Global Navigation Satellite System (GNSS) measurements. Many empirical correction models have been developed to compensate this delay, and models which do not require meteorological parameters have received the most attention. This study established a global troposphere zenith total delay (ZTD) model, called Global Empirical Orthogonal Function Troposphere (GEOFT), based on the empirical orthogonal function (EOF, also known as geographically weighted PCAs) analysis method and the Global Geodetic Observing System (GGOS) Atmosphere data from 2012 to 2015. The results showed that ZTD variation could be well represented by the characteristics of the EOF base function Ek and associated coefficients Pk. Here, E1 mainly signifies the equatorial anomaly; E2 represents north-south asymmetry, and E3 and E4 reflects regional variation. Moreover, P1 mainly reflects annual and semiannual variation components; P2 and P3 mainly contains annual variation components, and P4 displays semiannual variation components. We validated the proposed GEOFT model using tropospheric delay data of GGOS ZTD grid data and the tropospheric product of the International GNSS Service (IGS) over the year 2016. The results showed that GEOFT model has high accuracy with bias and RMS of -0.3 and 3.9 cm, respectively, with respect to the GGOS ZTD data, and of -0.8 and 4.1 cm, respectively, with respect to the global IGS tropospheric product. The accuracy of GEOFT demonstrating that the use of the EOF analysis method to characterize ZTD variation is reasonable.

The New Digital Media Value Network: Proposing an Interactive Model of Digital Media Value Activities

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Sylvia Chan-Olmsted

2016-07-01

Full Text Available This study models the dynamic nature of today’s media markets using the framework of value-adding activities in the provision and consumption of media products. The proposed user-centric approach introduces the notion that the actions of external users, social media, and interfaces affect the internal value activities of media firms via a feedback loop, and therefore should themselves be considered value activities. The model also suggests a more comprehensive list of indicators for value assessment.

Energetic models: a proposal of integrated planning; Modelos energeticos: uma proposta de planejamento integrado

Energy Technology Data Exchange (ETDEWEB)

Pereira Junior, Amaro Olimpio; Soares, Jeferson Borghetti; Araujo, Mauro Almeida [Empresa de Pesquisa Energetica (EPE), Brasilia, DF (Brazil)]. E-mails: amaro.pereira@epe.gov.br; jeferson.soares@epe.gov.br; mauro.almeida@epe.gov.br; La Rovere, Emilio Lebre [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-Graduacao de Engenharia. Programa de Planejamento Estrategico]. E-mail: emilio@ppe.ufrj.br; Costa, Ricardo Cunha da [Banco Nacional de Desenvolvimento Economico e Social (BNDES), Rio de Janeiro, RJ (Brazil)]. E-mail: rcco@bndes.gov.br

2006-07-01

Top-down, bottom-up and hybrid models for representing energy system are often used in energy planning. However, in developing countries some of their assumptions do not apply: markets are not developed and not competitive; informal economies are representative; there are huge social inequalities; regulatory changes are not completed; there exist constraints to capital flow; etc. All theses problems need to be well represented in order to have energy analysis more consistent. In this work, it is proposed a multi-sector dynamic recursive model that incorporates consumer behaviors, energy policies, technical progress and factors of production substitution. The static result feeds detailed energy models that provide updated values for the next step equilibrium. This approach takes advantages not only in terms of computation but also in terms of the consistence between economy and energy modeling. (author)

A Proposal of New Spherical Particle Modeling Method Based on Stochastic Sampling of Particle Locations in Monte Carlo Simulation

Energy Technology Data Exchange (ETDEWEB)

Kim, Song Hyun; Kim, Do Hyun; Kim, Jong Kyung [Hanyang Univ., Seoul (Korea, Republic of); Noh, Jea Man [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2013-10-15

To the high computational efficiency and user convenience, the implicit method had received attention; however, it is noted that the implicit method in the previous studies has low accuracy at high packing fraction. In this study, a new implicit method, which can be used at any packing fraction with high accuracy, is proposed. In this study, the implicit modeling method in the spherical particle distributed medium for using the MC simulation is proposed. A new concept in the spherical particle sampling was developed to solve the problems in the previous implicit methods. The sampling method was verified by simulating the sampling method in the infinite and finite medium. The results show that the particle implicit modeling with the proposed method was accurately performed in all packing fraction boundaries. It is expected that the proposed method can be efficiently utilized for the spherical particle distributed mediums, which are the fusion reactor blanket, VHTR reactors, and shielding analysis.

Methodology Using MELCOR Code to Model Proposed Hazard Scenario

Energy Technology Data Exchange (ETDEWEB)

Gavin Hawkley

2010-07-01

This study demonstrates a methodology for using the MELCOR code to model a proposed hazard scenario within a building containing radioactive powder, and the subsequent evaluation of a leak path factor (LPF) (or the amount of respirable material which that escapes a facility into the outside environment), implicit in the scenario. This LPF evaluation will analyzes the basis and applicability of an assumed standard multiplication of 0.5 × 0.5 (in which 0.5 represents the amount of material assumed to leave one area and enter another), for calculating an LPF value. The outside release is dependsent upon the ventilation/filtration system, both filtered and un-filtered, and from other pathways from the building, such as doorways (, both open and closed). This study is presents ed to show how the multiple leak path factorsLPFs from the interior building can be evaluated in a combinatory process in which a total leak path factorLPF is calculated, thus addressing the assumed multiplication, and allowing for the designation and assessment of a respirable source term (ST) for later consequence analysis, in which: the propagation of material released into the environmental atmosphere can be modeled and the dose received by a receptor placed downwind can be estimated and the distance adjusted to maintains such exposures as low as reasonably achievableALARA.. Also, this study will briefly addresses particle characteristics thatwhich affect atmospheric particle dispersion, and compares this dispersion with leak path factorLPF methodology.

Proposing a Qualitative Approach for Corporate Competitive Capability Modeling in High-Tech Business (Case study: Software Industry

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Mahmoud Saremi Saremi

2010-09-01

Full Text Available The evolution of global business trend for ICT-based products in recent decades shows the intensive activity of pioneer developing countries to gain a powerful competitive position in global software industry. In this research, with regard to importance of competition issue for top managers of Iranian software companies, a conceptual model has been developed for Corporate Competitive Capability concept. First, after describing the research problem, we present a comparative review of recent theories of firm and competition that has been applied by different researchers in the High-Tech and Knowledge Intensive Organization filed. Afterwards, with a detailed review of literature and previous research papers, an initial research framework and applied research method has been proposed. The main and final section of paper assigned to describing the result of research in different steps of qualitative modeling process. The agreed concepts are related to corporate competitive capability, the elicited and analyzed experts Cause Map, the elicited collective causal maps, and the final proposed model for software industry are the modeling results for this paper.

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

Science.gov (United States)

Yeste, Ada; Nadeau, Meghan; Burns, Evan J.; Weiner, Howard L.; Quintana, Francisco J.

2012-01-01

The immune response is normally controlled by regulatory T cells (Tregs). However, Treg deficits are found in autoimmune diseases, and therefore the induction of functional Tregs is considered a potential therapeutic approach for autoimmune disorders. The activation of the ligand-activated transcription factor aryl hydrocarbon receptor by 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) or other ligands induces dendritic cells (DCs) that promote FoxP3+ Treg differentiation. Here we report the use of nanoparticles (NPs) to coadminister ITE and a T-cell epitope from myelin oligodendrocyte glycoprotein (MOG)35–55 to promote the generation of Tregs by DCs. NP-treated DCs displayed a tolerogenic phenotype and promoted the differentiation of Tregs in vitro. Moreover, NPs carrying ITE and MOG35–55 expanded the FoxP3+ Treg compartment and suppressed the development of experimental autoimmune encephalomyelitis, an experimental model of multiple sclerosis. Thus, NPs are potential new tools to induce functional Tregs in autoimmune disorders. PMID:22745170

Advocating for School Psychologists in Response to the APA's Proposed "Model Act for State Licensure of Psychologists"

Science.gov (United States)

Skalski, Anastasia Kalamaros

2009-01-01

On March 6, 2009, the APA Model Licensure Act Task Force released its second draft of the policy document known as the proposed "Model Act for State Licensure of Psychologists". This policy document serves as guidance to state legislatures for how they should set up their psychology licensing laws. The general expectations promoted in the model…

Competency-Based University Undergraduate Teaching Management: Proposal for a Conceptual Model

Directory of Open Access Journals (Sweden)

Rodolfo Schmal

2005-12-01

Full Text Available The human resources societies and their organizations can count on are more and more relevant. In that sense, a major challenge faced by universities is to give students the appropriate background to be professionals with the profile the current scenario requires. This article focuses the management of university careers. Historically, many careers have emphasized knowledge, especially abstract knowledge. Today, the trend is to address aspects that reach beyond cognition, and focus the attention in effective competencies that include procedures and attitudes. Such approach allows the opportunity of defining a holistic management of careers, reaching beyond the sheer teaching of disciplines. Concurrently, the availability of information methods and tools will contribute for the definition and implementation of a design process that can work with explicit criteria and transformations. The article proposes a conceptual model to represent the objects, and their attributes and associations that are considered of interest for the management of university teaching under a competency focus. A second stage should implement such model through the construction of an information system that supports the management of corresponding careers.

A proposed adaptive step size perturbation and observation maximum power point tracking algorithm based on photovoltaic system modeling

Science.gov (United States)

Huang, Yu

Solar energy becomes one of the major alternative renewable energy options for its huge abundance and accessibility. Due to the intermittent nature, the high demand of Maximum Power Point Tracking (MPPT) techniques exists when a Photovoltaic (PV) system is used to extract energy from the sunlight. This thesis proposed an advanced Perturbation and Observation (P&O) algorithm aiming for relatively practical circumstances. Firstly, a practical PV system model is studied with determining the series and shunt resistances which are neglected in some research. Moreover, in this proposed algorithm, the duty ratio of a boost DC-DC converter is the object of the perturbation deploying input impedance conversion to achieve working voltage adjustment. Based on the control strategy, the adaptive duty ratio step size P&O algorithm is proposed with major modifications made for sharp insolation change as well as low insolation scenarios. Matlab/Simulink simulation for PV model, boost converter control strategy and various MPPT process is conducted step by step. The proposed adaptive P&O algorithm is validated by the simulation results and detail analysis of sharp insolation changes, low insolation condition and continuous insolation variation.

A Proposed Model for Assessing Organisational Culture Towards Achieving Business Objectives

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Hafez Salleh

2011-09-01

Full Text Available Most of the traditional business performances measures are based on productivity and process criteria, which mainly focus on method of investment appraisal such as payback method, return on investment (ROI, cost-benefits analysis (CBA, net present value (NPV, internal rate of return (IRR. However, the measurement scales of business performance are not limited to those measures. One element that has strong correlation to the business performances is ‘organisational culture’. Many studies proved that one of the significant criteria for achieving desired business objectives is the right organisational culture within workplace. Basically, the measurement of organisational culture is reflecting on two distinct elements: organisational culture and business objectives. In broader perspective, an organisation is considered effective if it meets its business objectives. This paper aims to present and discuss the preliminary culture model to indicate the culture performance within organisational. The model has been developed through literature review, expert opinion and experience which is anticipated of being able to potentially measure the culture capability of organisations across industries to “successfully achieve business objectives”. The model is composed of six progressive stages of maturity that an organisation can achieve its culture performance. For each maturity stage, the model describes a set of characteristics that must be in place for the company to achieve each stage. The validity of the proposed model will be tested by a few case studies. The idea is to provide managers with a qualitative measurement tools to enable them to identify where culture improvements are required within their organisations and to indicate their readiness for achieving business objectives.

Proposal of a congestion control technique in LAN networks using an econometric model ARIMA

Directory of Open Access Journals (Sweden)

Joaquín F Sánchez

2017-01-01

Full Text Available Hasty software development can produce immediate implementations with source code unnecessarily complex and hardly readable. These small kinds of software decay generate a technical debt that could be big enough to seriously affect future maintenance activities. This work presents an analysis technique for identifying architectural technical debt related to non-uniformity of naming patterns; the technique is based on term frequency over package hierarchies. The proposal has been evaluated on projects of two popular organizations, Apache and Eclipse. The results have shown that most of the projects have frequent occurrences of the proposed naming patterns, and using a graph model and aggregated data could enable the elaboration of simple queries for debt identification. The technique has features that favor its applicability on emergent architectures and agile software development.

The modeling of contaminant flow during proposed treatment of U.S. Department of Energy low-level radioactive mixed wastes

International Nuclear Information System (INIS)

Dolak, D.A.; Wilkins, B.D.; Kotek, T.J.; Wang, Y.Y.; Meshkov, N.K.

1995-01-01

Estimations of waste materials throughput and the potential radiological and chemical releases resulting from the proposed treatment of US Department of Energy (DOE) low-level mixed wastes (LLMWs) were used to support analyses of risks and costs associated with various waste management alternatives outlined in the Office of Environmental Management Programmatic Environmental Impact Statement (EM PEIS). The modeling of material flow and contaminant releases through a consolidated waste management flowchart was performed by the WASTE MGMT computational model developed by Argonne National Laboratory. This paper (1) briefly describes the process used to model estimated material and contaminant flow through the proposed treatment scenarios for the EM PEIS, (2) discusses the key site- and/or waste-stream-dependent factors involved in the determination of radiological and chemical emissions, and (3) explains the assumptions used to integrate the available LLMW database with the computational model

Proposed shake table studies for NAPP containment

International Nuclear Information System (INIS)

Akolkar, P.M.; Khuddus, M.A.

1975-01-01

The proposal for shake table studies on model of containment structure of Narora Atomic Power Project is discussed. The physical characteristics such as the dimensions, connection details of the containment with the internal structure and the dynamic interaction between the two have been described. The dynamic scale factors obtained through similitude requirements and dimensional analysis have been presented and the modelling aspects and the choice of model material and scale have been discussed. The proposed type of tests, necessary measurement and instrumentation have been mentioned. The limitations imposed by similitude requirements on model studies are brought out and the usefulness of the results of the proposed tests in the dynamic design of the containment have been covered. (author)

Cortical dynamics of visual change detection based on sensory memory.

Science.gov (United States)

Urakawa, Tomokazu; Inui, Koji; Yamashiro, Koya; Tanaka, Emi; Kakigi, Ryusuke

2010-08-01

Detecting a visual change was suggested to relate closely to the visual sensory memory formed by visual stimuli before the occurrence of the change, because change detection involves identifying a difference between ongoing and preceding sensory conditions. Previous neuroimaging studies showed that an abrupt visual change activates the middle occipital gyrus (MOG). However, it still remains to be elucidated whether the MOG is related to visual change detection based on sensory memory. Here we tried to settle this issue using a new method of stimulation with blue and red LEDs to emphasize a memory-based change detection process. There were two stimuli, a standard trial stimulus and a deviant trial stimulus. The former was a red light lasting 500 ms, and the latter was a red light lasting 250 ms immediately followed by a blue light lasting 250 ms. Effects of the trial-trial interval, 250 approximately 2000 ms, were investigated to know how cortical responses to the abrupt change (from red to blue) were affected by preceding conditions. The brain response to the deviant trial stimulus was recorded by magnetoencephalography. Results of a multi-dipole analysis showed that the activity in the MOG, peaking at around 150 ms after the change onset, decreased in amplitude as the interval increased, but the earlier activity in BA 17/18 was not affected by the interval. These results suggested that the MOG is an important cortical area relating to the sensory memory-based visual change-detecting system. Copyright 2010 Elsevier Inc. All rights reserved.

Tourism Cluster Competitiveness and Sustainability: Proposal for a Systemic Model to Measure the Impact of Tourism on Local Development

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Sieglinde Kindl da Cunha

2005-07-01

Full Text Available This article proposes a model to measure tourism cluster impact on local development with a view to assessing tourism cluster interaction, competitiveness and sustainability impacts on the economy, society and the environment. The theoretical basis for this model is founded on cluster concept and typology adapting and integrating the systemic competitiveness and sustainability concepts within economic, social, cultural, environmental and political dimensions. The proposed model shows a holistic, multidisciplinary and multi-sector view of local development brought back through a systemic approach to the concepts of competitiveness, social equity and sustainability. Its results make possible strategic guidance to agents responsible for public sector tourism policies, as well as the strategies for competitiveness, competition, cooperation and sustainability in private companies and institutions.

Proposals for measuring transversity distributions in deep inelastic electron scattering and a model for E-704 asymmetries

International Nuclear Information System (INIS)

Artru, X.

1993-10-01

The principles of the measurement of the quark transversity distributions in semi-inclusive deep inelastic electron scattering are presented, which form the basis of Hydrogen jet target in the LEP tunnel (HELP) and one of the European Laboratory For Electron (ELFE) proposals. A string model for Collins-type asymmetry in polarized quark fragmentation function is proposed. A possible role of the Collins effect in the single spin asymmetries observed by experiment E 704 at Fermilab is suggested. (author) 13 refs., 3 figs

Proposed retention model for human inhalation exposure to 241AmO2

International Nuclear Information System (INIS)

Mewhinney, J.A.; Griffith, W.C.; Muggenburg, B.A.

1980-01-01

A dosimetry model based on a four-year study in Beagle dogs was developed to predict patterns of absorbed radiation doses for people exposed by inhalation to 241 AmO 2 . Following a single inhalation exposure to one of three sizes of monodisperse or a polydisperse aerosol of 241 AmO 2 , pairs of dogs were sacrificed at 8, 32, 64 and 256 days, and 2 and 4 years. For about 80% of the initial lung burden, the retention halftimes were 11, 18, 26 and 27 days for the 0.75, 1.5 and 3.0 μm aerodynamic diameter and the 1.8 μm activity median aerodynamic diameter aerosols, respectively. For the remaining 20% of the initial lung burden, the retention halftimes were between 200 to 300 days with no apparent particle size influence. Additional 241 Am metabolic studies reported in the literature using inhalation exposure or injection of the citrate complex were synthesized in the model as were eleven reported cases of human inhalation exposure. This model is compared to the ICRP II and TGLD lung models, both developed by analogy to Pu metabolism. The proposed model differs from these latter models in two important areas: (a) lung retention of 241 AmO 2 could not be adapted to the classifications used in these models, and (b) the fractional translocation from lung to other organs is 2 to 8 times larger. These factors considerably alter the predicted radiation dose distribution among organs and lead to the conclusion that derived radiation protection standards for 241 AmO 2 inhalation exposure should be modified. (author)

Proposal of a stationary model of dispersion diagnoses of pollutants chemically non-reactivate, applied for mobile sources in Bogota

International Nuclear Information System (INIS)

Ruiz Murcia, Jose Franklln; Pabon Caicedo, Jose Daniel

2002-01-01

The following document presents a semi empirical model to calculate concentrations of monoxide of carbon in surface by mobile sources. This model considers three basic components: meteorology, emissions and atmospheric chemistry. Scientifically, the propose model is sustained en the fact that the quality of the air depends of the weather's conditions and the numbers of source that is emitting

Socio-economic vulnerability to natural hazards - proposal for an indicator-based model

Science.gov (United States)

Eidsvig, U.; McLean, A.; Vangelsten, B. V.; Kalsnes, B.; Ciurean, R. L.; Argyroudis, S.; Winter, M.; Corominas, J.; Mavrouli, O. C.; Fotopoulou, S.; Pitilakis, K.; Baills, A.; Malet, J. P.

2012-04-01

Vulnerability assessment, with respect to natural hazards, is a complex process that must consider multiple dimensions of vulnerability, including both physical and social factors. Physical vulnerability refers to conditions of physical assets, and may be modeled by the intensity and magnitude of the hazard, the degree of physical protection provided by the natural and built environment, and the physical robustness of the exposed elements. Social vulnerability refers to the underlying factors leading to the inability of people, organizations, and societies to withstand impacts from the natural hazards. Social vulnerability models can be used in combination with physical vulnerability models to estimate both direct losses, i.e. losses that occur during and immediately after the impact, as well as indirect losses, i.e. long-term effects of the event. Direct impact of a landslide typically includes casualties and damages to buildings and infrastructure while indirect losses may e.g. include business closures or limitations in public services. The direct losses are often assessed using physical vulnerability indicators (e.g. construction material, height of buildings), while indirect losses are mainly assessed using social indicators (e.g. economical resources, demographic conditions). Within the EC-FP7 SafeLand research project, an indicator-based method was proposed to assess relative socio-economic vulnerability to landslides. The indicators represent the underlying factors which influence a community's ability to prepare for, deal with, and recover from the damage associated with landslides. The proposed model includes indicators representing demographic, economic and social characteristics as well as indicators representing the degree of preparedness and recovery capacity. Although the model focuses primarily on the indirect losses, it could easily be extended to include more physical indicators which account for the direct losses. Each indicator is individually

Proposing a Model to present Factors which Affect e-SCM Risk and their Impacts on Organizational Performance

Directory of Open Access Journals (Sweden)

ali rajabzadeh ghatari

2010-03-01

Full Text Available Companies strive to improve market share, grow corporate profit, and gain strategic advantage. In order to achieve these goals, supply chain competency must be placed at the heart of a company’s business model. Using e-Commerce and information and communication technologies (ICT in today’s changing demands of business has made organizations more responsive and flexible. E-Commerce and Internet have changed the nature of supply chains and re-defined how customers obtain wisdom of products, services, selection, purchasing and using them. Advent of ICT and new business environment has caused emerge of electronic supply chains. This research has proposed a model for presenting factors which affect electronic supply chain’s risk; besides the influence of the risk on financial and non-financial organization’s performance indicators. Studying the influence of the risk on organization’s performance is conducted in a sample of electronic and telecommunication companies. In order to measure these relationships, using correlation and structural equation modeling (SEM techniques proposed that electronic supply chain risk identification and management have significant impact on organization’s performance improvement.

Modeling oscillatory dynamics in brain microcircuits as a way to help uncover neurological disease mechanisms: A proposal

Energy Technology Data Exchange (ETDEWEB)

Skinner, F. K. [Toronto Western Research Institute, University Health Network, Krembil Discovery Tower, Toronto Western Hospital, 60 Leonard Street, 7th floor, 7KD411, Toronto, Ontario M5T 2S8 (Canada); Department of Medicine (Neurology), University of Toronto, 200 Elizabeth Street, Toronto, Ontario M5G 2C4 (Canada); Department of Physiology, University of Toronto Medical Sciences Building, 3rd Floor, 1 King' s College Circle, Toronto, Ontario M5S 1A8 (Canada); Ferguson, K. A. [Toronto Western Research Institute, University Health Network, Krembil Discovery Tower, Toronto Western Hospital, 60 Leonard Street, 7th floor, 7KD411, Toronto, Ontario M5T 2S8 (Canada); Department of Physiology, University of Toronto Medical Sciences Building, 3rd Floor, 1 King' s College Circle, Toronto, Ontario M5S 1A8 (Canada)

2013-12-15

There is an undisputed need and requirement for theoretical and computational studies in Neuroscience today. Furthermore, it is clear that oscillatory dynamical output from brain networks is representative of various behavioural states, and it is becoming clear that one could consider these outputs as measures of normal and pathological brain states. Although mathematical modeling of oscillatory dynamics in the context of neurological disease exists, it is a highly challenging endeavour because of the many levels of organization in the nervous system. This challenge is coupled with the increasing knowledge of cellular specificity and network dysfunction that is associated with disease. Recently, whole hippocampus in vitro preparations from control animals have been shown to spontaneously express oscillatory activities. In addition, when using preparations derived from animal models of disease, these activities show particular alterations. These preparations present an opportunity to address challenges involved with using models to gain insight because of easier access to simultaneous cellular and network measurements, and pharmacological modulations. We propose that by developing and using models with direct links to experiment at multiple levels, which at least include cellular and microcircuit, a cycling can be set up and used to help us determine critical mechanisms underlying neurological disease. We illustrate our proposal using our previously developed inhibitory network models in the context of these whole hippocampus preparations and show the importance of having direct links at multiple levels.

Evaluating the impact a proposed family planning model would have on maternal and infant mortality in Afghanistan.

Science.gov (United States)

Rahmani, Ahmad Masoud; Wade, Benjamin; Riley, William

2015-01-01

This study aimed to assess the potential impact a proposed family planning model would have on reducing maternal and infant mortality in Afghanistan. Afghanistan has a high total fertility rate, high infant mortality rate, and high maternal mortality rate. Afghanistan also has tremendous socio-cultural barriers to and misconceptions about family planning services. We applied predictive statistical models to a proposed family planning model for Afghanistan to better understand the impact increased family planning can have on Afghanistan's maternal mortality rate and infant mortality rate. We further developed a sensitivity analysis that illustrates the number of maternal and infant deaths that can be averted over 5 years according to different increases in contraceptive prevalence rates. Incrementally increasing contraceptive prevalence rates in Afghanistan from 10% to 60% over the course of 5 years could prevent 11,653 maternal deaths and 317,084 infant deaths, a total of 328,737 maternal and infant deaths averted. Achieving goals in reducing maternal and infant mortality rates in Afghanistan requires a culturally relevant approach to family planning that will be supported by the population. The family planning model for Afghanistan presents such a solution and holds the potential to prevent hundreds of thousands of deaths. Copyright © 2013 John Wiley & Sons, Ltd.

Citygml and the Streets of New York - a Proposal for Detailed Street Space Modelling

Science.gov (United States)

Beil, C.; Kolbe, T. H.

2017-10-01

Three-dimensional semantic city models are increasingly used for the analysis of large urban areas. Until now the focus has mostly been on buildings. Nonetheless many applications could also benefit from detailed models of public street space for further analysis. However, there are only few guidelines for representing roads within city models. Therefore, related standards dealing with street modelling are examined and discussed. Nearly all street representations are based on linear abstractions. However, there are many use cases that require or would benefit from the detailed geometrical and semantic representation of street space. A variety of potential applications for detailed street space models are presented. Subsequently, based on related standards as well as on user requirements, a concept for a CityGML-compliant representation of street space in multiple levels of detail is developed. In the course of this process, the CityGML Transportation model of the currently valid OGC standard CityGML2.0 is examined to discover possibilities for further developments. Moreover, a number of improvements are presented. Finally, based on open data sources, the proposed concept is implemented within a semantic 3D city model of New York City generating a detailed 3D street space model for the entire city. As a result, 11 thematic classes, such as roadbeds, sidewalks or traffic islands are generated and enriched with a large number of thematic attributes.

THEORETICAL AND EXPERIMENTAL CONTRIBUTIONS CONCERNING THE PROPOSED MODEL FOR THE DISC-TYPED ROTARY ULTRASONIC MOTOR

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Oana CHIVU

2010-10-01

Full Text Available In this work the proposed model for type-disk, ultrasonic motor rotating, elliptic movement to surface beam. A sinusoidal vibration of the vertical displacement in the z-direction, Assume that the vertical displacement of the neutral plane, equals the product of the slope of the neutral plane and half of the beam height, the tangential velocity vs at the upper surface is given.

Models including electron correlation in relation to Fock's proposed expansion of the ground-state wave function of He-like atomic ions

Energy Technology Data Exchange (ETDEWEB)

Glasser, M. L.; March, N. H.; Nieto, L. M. [Departamento de Fisica Teorica, Atomica y Optica, Universidad de Valladolid, ES-47011 Valladolid, Spain and Department of Physics, Clarkson University, Potsdam, New York 13699 (United States); Department of Physics, University of Antwerp, BE-2020 Antwerp, Belgium and Department of Theoretical Chemistry, University of Oxford, Oxford OX1 2JD (United Kingdom); Departamento de Fisica Teorica, Atomica y Optica, Universidad de Valladolid, ES-47011 Valladolid (Spain)

2011-12-15

Here attention is first drawn to the importance of gaining insight into Fock's early proposal for expanding the ground-state wave function for He-like atomic ions in hyperspherical coordinates. We approach the problem via two solvable models, namely, (i) the s-term model put forth by Temkin [Phys. Rev. 126, 130 (1962)] and (ii) the Hookean atom model proposed by Kestner and Sinanoglu [Phys. Rev. 128, 2687 (1962)]. In both cases the local kinetic energy can be obtained explicitly in hyperspherical coordinates. Separation of variables occurs in both model wave functions, though in a different context in the two cases. Finally, a k-space formulation is proposed that should eventually result in distinctive identifying characteristics of Fock's nonanalyticities for He-like atomic ions when both electrons are close to the nucleus.

Equivalent flow rate concept used in near field transport model COMP23 - Proposed values for SR 97

International Nuclear Information System (INIS)

Moreno, L.

1998-11-01

SKB is using NUCTRAN to calculate transport of radionuclides from a possible defective canister into the far field. NUCTRAN is included in the Performance Assessment model chain that calculates the release from the canister into the biosphere. In the chain, NUCTRAN is denoted COMP23. In order to calculate the transport of radionuclides by diffusion into the flowing water in the rock, NUCTRAN uses the concept of equivalent flow rate, Q eq . To calculate the value of Q eq in the different paths, COMP23 needs information about the Darcy velocity, the geometry of the system, material properties and the flow porosity in the rock. At present, this information is supplied to COMP23 by means of three parameters. The aim of this note is to propose a method to calculate the flow equivalent within the SR 97 project. Estimated intervals of the factors to adopt HYDRASTAR results to COMP23 are presented. Since it is difficult to give general validity to the factors, solely proposed factor intervals are presented to obtain equivalent flow rate values for COMP23. To obtain accurate equivalent flow rate values, information about the hydraulic conditions at canister locations in the groundwater model should be available for the near field model or the Q eq values could be calculated directly in the groundwater flow model. One of the main tasks in the SR 97 project is to show the barrier performance of the rock using different alternative models for flow and transport. In addition, the Alternative Model Project (AMP) aims to show how robust the assessment model description is, in terms of relevant far field performance measures. In the AMP, three main approaches were used, namely, the Stochastic Continuum approach, the Channel Network model and the Discrete Feature Network model

Determinação de autoanticorpos para antígenos da mielina no soro de pacientes HLA - DQB1*0602 com esclerose múltipla

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Carvalho Adriana

2003-01-01

Full Text Available Esclerose múltipla (EM é doença inflamatória desmielinizante do sistema nervoso central (SNC de natureza autoimune, mediada por linfócitos Th1. A produção de autoanticorpos séricos para proteína básica da mielina (MBP, proteolipídeo PLP e sequência da glicoproteína de oligodendrócito MOG 92-106, foi determinada em 54 indivíduos saudáveis e 26 pacientes com EM expressando ou não o alelo de suscetibilidade HLA-DQB1*0602. Independentemente da expressão do alelo DQB1*0602, todos os pacientes apresentaram produção marcante (p< 0,0001 de autoanticorpos isotipo IgG para MBP e MOG 92-106, e do isotipo IgA para PLP e MOG 92-106. Os resultados sugerem que outros alelos HLA da classe II exerçam influência na suscetibilidade à EM e no reconhecimento imunológico dos antígenos encefalitogênicos, determinando o padrão de resposta autoimune e contribuindo na manutenção e/ou controle da inflamação no SNC.

Functional connectivity modeling of consistent cortico-striatal degeneration in Huntington's disease

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Imis Dogan

2015-01-01

Full Text Available Huntington's disease (HD is a progressive neurodegenerative disorder characterized by a complex neuropsychiatric phenotype. In a recent meta-analysis we identified core regions of consistent neurodegeneration in premanifest HD in the striatum and middle occipital gyrus (MOG. For early manifest HD convergent evidence of atrophy was most prominent in the striatum, motor cortex (M1 and inferior frontal junction (IFJ. The aim of the present study was to functionally characterize this topography of brain atrophy and to investigate differential connectivity patterns formed by consistent cortico-striatal atrophy regions in HD. Using areas of striatal and cortical atrophy at different disease stages as seeds, we performed task-free resting-state and task-based meta-analytic connectivity modeling (MACM. MACM utilizes the large data source of the BrainMap database and identifies significant areas of above-chance co-activation with the seed-region via the activation-likelihood-estimation approach. In order to delineate functional networks formed by cortical as well as striatal atrophy regions we computed the conjunction between the co-activation profiles of striatal and cortical seeds in the premanifest and manifest stages of HD, respectively. Functional characterization of the seeds was obtained using the behavioral meta-data of BrainMap. Cortico-striatal atrophy seeds of the premanifest stage of HD showed common co-activation with a rather cognitive network including the striatum, anterior insula, lateral prefrontal, premotor, supplementary motor and parietal regions. A similar but more pronounced co-activation pattern, additionally including the medial prefrontal cortex and thalamic nuclei was found with striatal and IFJ seeds at the manifest HD stage. The striatum and M1 were functionally connected mainly to premotor and sensorimotor areas, posterior insula, putamen and thalamus. Behavioral characterization of the seeds confirmed that experiments

Proposal of a new biokinetic model for niobium; Proposta de um novo modelo biocinetico para o niobio

Energy Technology Data Exchange (ETDEWEB)

Oliveira, Roges

2006-07-01

There are two niobium isotopes generated in nuclear power plants: 95 Nb and 94 Nb. Workers and members of the public are subjects to intake these radionuclides in accident situation. For dose calculation purpose, it is very important to develop a model that describes in a more realistic way the kinetics of niobium inside of the human body. Presently the model adopted by ICRP (ICRP, 1989) is based on animal studies and describes the behavior of niobium in human being in a simple manner. The new model proposal describes the kinetics of the niobium from the intake into the blood until the excretion, doing this in a more realistic form and considering not only data from animals but data from human beings as well. For this objective, a workers group of a niobium extraction and processing industry exposed to stable niobium (93 Nb) in oxide insoluble form with associated uranium, was monitored for uranium and niobium determination in urinary and fecal excretion, by mass spectrometry. Based in the ratios of the niobium concentration in urinary and faecal excretion of this workers and animal data study, a new biokinetic model for niobium was proposed, with the followings modifications relative to ICRP model: a new compartment that represents muscular tissue; the fractions which are deposited into the compartment are modified; a third component in the retention equation of the bone tissue; introduction of recirculation between organs and blood. The new model was applied for a case of accidental intake and described adequately the experimental data.

A proposed model of factors influencing hydrogen fuel cell vehicle acceptance

Science.gov (United States)

Imanina, N. H. Noor; Kwe Lu, Tan; Fadhilah, A. R.

2016-03-01

Issues such as environmental problem and energy insecurity keep worsening as a result of energy use from household to huge industries including automotive industry. Recently, a new type of zero emission vehicle, hydrogen fuel cell vehicle (HFCV) has received attention. Although there are argues on the feasibility of hydrogen as the future fuel, there is another important issue, which is the acceptance of HFCV. The study of technology acceptance in the early stage is a vital key for a successful introduction and penetration of a technology. This paper proposes a model of factors influencing green vehicle acceptance, specifically HFCV. This model is built base on two technology acceptance theories and other empirical studies of vehicle acceptance. It aims to provide a base for finding the key factors influencing new sustainable energy fuelled vehicle, HFCV acceptance which is achieved by explaining intention to accept HFCV. Intention is influenced by attitude, subjective norm and perceived behavioural control from Theory of Planned Behaviour and personal norm from Norm Activation Theory. In the framework, attitude is influenced by perceptions of benefits and risks, and social trust. Perceived behavioural control is influenced by government interventions. Personal norm is influenced by outcome efficacy and problem awareness.

MO-G-17A-04: Internal Dosimetric Calculations for Pediatric Nuclear Imaging Applications, Using Monte Carlo Simulations and High-Resolution Pediatric Computational Models

Energy Technology Data Exchange (ETDEWEB)

Papadimitroulas, P; Kagadis, GC [University of Patras, Rion, Ahaia (Greece); Loudos, G [Technical Educational Institute of Athens, Aigaleo, Attiki (Greece)

2014-06-15

Purpose: Our purpose is to evaluate the administered absorbed dose in pediatric, nuclear imaging studies. Monte Carlo simulations with the incorporation of pediatric computational models can serve as reference for the accurate determination of absorbed dose. The procedure of the calculated dosimetric factors is described, while a dataset of reference doses is created. Methods: Realistic simulations were executed using the GATE toolkit and a series of pediatric computational models, developed by the “IT'IS Foundation”. The series of the phantoms used in our work includes 6 models in the range of 5–14 years old (3 boys and 3 girls). Pre-processing techniques were applied to the images, to incorporate the phantoms in GATE simulations. The resolution of the phantoms was set to 2 mm3. The most important organ densities were simulated according to the GATE “Materials Database”. Several used radiopharmaceuticals in SPECT and PET applications are being tested, following the EANM pediatric dosage protocol. The biodistributions of the several isotopes used as activity maps in the simulations, were derived by the literature. Results: Initial results of absorbed dose per organ (mGy) are presented in a 5 years old girl from the whole body exposure to 99mTc - SestaMIBI, 30 minutes after administration. Heart, kidney, liver, ovary, pancreas and brain are the most critical organs, in which the S-factors are calculated. The statistical uncertainty in the simulation procedure was kept lower than 5%. The Sfactors for each target organ are calculated in Gy/(MBq*sec) with highest dose being absorbed in kidneys and pancreas (9.29*10{sup 10} and 0.15*10{sup 10} respectively). Conclusion: An approach for the accurate dosimetry on pediatric models is presented, creating a reference dosage dataset for several radionuclides in children computational models with the advantages of MC techniques. Our study is ongoing, extending our investigation to other reference models and

MO-G-17A-04: Internal Dosimetric Calculations for Pediatric Nuclear Imaging Applications, Using Monte Carlo Simulations and High-Resolution Pediatric Computational Models

International Nuclear Information System (INIS)

Papadimitroulas, P; Kagadis, GC; Loudos, G

2014-01-01

Purpose: Our purpose is to evaluate the administered absorbed dose in pediatric, nuclear imaging studies. Monte Carlo simulations with the incorporation of pediatric computational models can serve as reference for the accurate determination of absorbed dose. The procedure of the calculated dosimetric factors is described, while a dataset of reference doses is created. Methods: Realistic simulations were executed using the GATE toolkit and a series of pediatric computational models, developed by the “IT'IS Foundation”. The series of the phantoms used in our work includes 6 models in the range of 5–14 years old (3 boys and 3 girls). Pre-processing techniques were applied to the images, to incorporate the phantoms in GATE simulations. The resolution of the phantoms was set to 2 mm3. The most important organ densities were simulated according to the GATE “Materials Database”. Several used radiopharmaceuticals in SPECT and PET applications are being tested, following the EANM pediatric dosage protocol. The biodistributions of the several isotopes used as activity maps in the simulations, were derived by the literature. Results: Initial results of absorbed dose per organ (mGy) are presented in a 5 years old girl from the whole body exposure to 99mTc - SestaMIBI, 30 minutes after administration. Heart, kidney, liver, ovary, pancreas and brain are the most critical organs, in which the S-factors are calculated. The statistical uncertainty in the simulation procedure was kept lower than 5%. The Sfactors for each target organ are calculated in Gy/(MBq*sec) with highest dose being absorbed in kidneys and pancreas (9.29*10 10 and 0.15*10 10 respectively). Conclusion: An approach for the accurate dosimetry on pediatric models is presented, creating a reference dosage dataset for several radionuclides in children computational models with the advantages of MC techniques. Our study is ongoing, extending our investigation to other reference models and evaluating the

Ecological planning proposal for Kruger National Park

Science.gov (United States)

van Riet, W. F.; Cooks, J.

1990-05-01

This article discusses an application of the ecological planning model proposed by Van Riet and Cooks. The various steps outlined in this model have been applied to Kruger National Park in South Africa. The natural features of Kruger National Park, which form the basis of such an ecological planning exercise and from which the various land use categories, values, and zoning classes can be determined, are discussed in detail. The suitability of each of the various features is analyzed and a final zoning proposal for Kruger National Park is suggested. Furthermore a method for selecting a site for a new camp is illustrated by referring to the site for the new Mopane rest camp which is now under construction in the Kruger National Park. The conclusion is reached that the proposed ecological planning model can be used successfully in planning conservation areas such as Kruger National Park and for the selection of the most desirable sites for the establishment of new rest camps. Its suitability as a practical model in such planning exercises is proven by the fact that the siting proposals of two new camps based on this model have been accepted by the National Parks Board, the controlling body of Kruger National Park.

From representing to modelling knowledge: Proposing a two-step training for excellence in concept mapping

Directory of Open Access Journals (Sweden)

Joana G. Aguiar

2017-09-01

Full Text Available Training users in the concept mapping technique is critical for ensuring a high-quality concept map in terms of graphical structure and content accuracy. However, assessing excellence in concept mapping through structural and content features is a complex task. This paper proposes a two-step sequential training in concept mapping. The first step requires the fulfilment of low-order cognitive objectives (remember, understand and apply to facilitate novices’ development into good Cmappers by honing their knowledge representation skills. The second step requires the fulfilment of high-order cognitive objectives (analyse, evaluate and create to grow good Cmappers into excellent ones through the development of knowledge modelling skills. Based on Bloom’s revised taxonomy and cognitive load theory, this paper presents theoretical accounts to (1 identify the criteria distinguishing good and excellent concept maps, (2 inform instructional tasks for concept map elaboration and (3 propose a prototype for training users on concept mapping combining online and face-to-face activities. The proposed training application and the institutional certification are the next steps for the mature use of concept maps for educational as well as business purposes.

Hydrogeologic modelling in support of a proposed Deep Geologic Repository in Canada for low and intermediate level radioactive waste

Energy Technology Data Exchange (ETDEWEB)

Sykes, J.F.; Normani, S.D.; Yin, Y. [Waterloo Univ., ON (Canada). Dept. of Civil and Environmental Engineering; Sykes, E.A.; Jensen, M.R. [Nuclear Waste Management Organization, Toronto, ON (Canada)

2009-07-01

Ontario Power Generation (OPG) has proposed the construction of a Deep Geologic Repository (DGR) for low and intermediate level radioactive waste at the Bruce site on the shore of Lake Huron near Tiverton, Ontario. The DGR is to be excavated at a depth of about 680 m within argillaceous limestones of Ordovician age. A saturated regional-scale and site-scale numerical modelling study has been completed in order to evaluate the safety of storing radioactive waste at the site and to better understand the geochemistry and hydrogeology of the formations surrounding the proposed DGR. This paper reported on the regional-scale base-case modelling and analysis of the measured pressure profile in deep boreholes at the DGR site. The numerical modelling study provided a framework to investigate the groundwater flow system as it relates to, and potentially affects, the safety and long-term performance of the DGR. A saturated groundwater flow model was also developed using FRAC3DVS-OPG. The objective of regional-scale groundwater modelling of the Paleozoic sedimentary sequence underlying southwestern Ontario was to provide a basis for the assembly and integration of site-specific geoscientific data and to explain the influence of parameter and scenario uncertainty on predicted long-term geosphere barrier performance. The base-case analysis showed that solute transport in the Ordovician and lower Silurian is diffusion dominant. For the base-case parameters, the estimated mean life expectancy for the proposed DGR is more than 8 million years. The possible presence of a gas phase in the rock between the Cambrian and the Niagaran was not considered in the analyses of this paper. 9 refs., 2 tabs., 10 figs.

Proposal of a model for sales and operations planning (S&OP maturity evaluation

Directory of Open Access Journals (Sweden)

Carolina Belotti Pedroso

2017-11-01

Full Text Available Abstract A successful S&OP implementation can bring many benefits to organizations, and after its implementation, the S&OP process can evolve and reach higher levels of maturity. Considering that, only through a measurement system, goals and benefits can be achieved, thus, it is essential to assess S&OP maturity level. Many papers on literature adopt a quantitative perspective on S&OP, but just few of them deal with uncertainty present in S&OP decision-making, such as maturity model assessment process that carries subjectivity and uncertainty. Thus, this study proposes a decision making model based on fuzzy theory to evaluate and to categorize S&OP maturity levels and to suggest strategies to increase S&OP maturity. A pilot application was conducted in two manufacturing organizations that have implemented the S&OP process. The results, according to the performance presented, suggest different actions must be taken in terms of ensuring enablers to S&OP implementation.

Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

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Yan Zhou

2016-01-01

Full Text Available It is well known that dendritic cells (DCs play a pivotal role in triggering self-specific responses. Conversely, tolerogenic DCs (tolDCs, a specialized subset, induce tolerance and negatively regulate autoreactive responses. Tofacitinib, a Janus kinase inhibitor developed by Pfizer for treatment of rheumatoid arthritis, is probable to be a promising candidate for inducing tolDCs. The aims of this study were to evaluate the effectiveness of tolDCs induced by tofacitinib in a myelin oligodendrocyte glycoprotein- (MOG- specific experimental autoimmune encephalomyelitis (EAE model and to investigate their effects on Th17/Treg balance in the animal model of multiple sclerosis (MS. Our results revealed that tofacitinib-treated DCs maintained a steady semimature phenotype with a low level of proinflammatory cytokines and costimulatory molecules. DCs treated by tofacitinib also induced antigen-specific T cells hyporesponsiveness in a concentration-dependent manner. Upon intravenous injection into EAE mice, MOG pulsed tolDCs significantly dampened disease activity, and adoptive cell therapy (ACT disturbed Th17/Treg balance with a remarkable decrease of Th1/Th17 cells and an increase in regulatory T cells (Tregs. Overall, DCs modified by tofacitinib exhibited a typical tolerogenic phenotype, and the antigen-specific tolDCs may represent a new avenue of research for the development of future clinical treatments for MS.

A proposed defect tracking model for classifying the inserted defect reports to enhance software quality control.

Science.gov (United States)

Sultan, Torky; Khedr, Ayman E; Sayed, Mostafa

2013-01-01

NONE DECLARED Defect tracking systems play an important role in the software development organizations as they can store historical information about defects. There are many research in defect tracking models and systems to enhance their capabilities to be more specifically tracking, and were adopted with new technology. Furthermore, there are different studies in classifying bugs in a step by step method to have clear perception and applicable method in detecting such bugs. This paper shows a new proposed defect tracking model for the purpose of classifying the inserted defects reports in a step by step method for more enhancement of the software quality.

A proposed centralised distribution model for the South African automotive component industry

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Micheline J. Naude

2009-12-01

Full Text Available Purpose: This article explores the possibility of developing a distribution model, similar to the model developed and implemented by the South African pharmaceutical industry, which could be implemented by automotive component manufacturers for supply to independent retailers. Problem Investigated: The South African automotive components distribution chain is extensive with a number of players of varying sizes, from the larger spares distribution groups to a number of independent retailers. Distributing to the smaller independent retailers is costly for the automotive component manufacturers. Methodology: This study is based on a preliminary study of an explorative nature. Interviews were conducted with a senior staff member from a leading automotive component manufacturer in KwaZulu Natal and nine participants at a senior management level at five of their main customers (aftermarket retailers. Findings: The findings from the empirical study suggest that the aftermarket component industry is mature with the role players well established. The distribution chain to the independent retailer is expensive in terms of transaction and distribution costs for the automotive component manufacturer. A proposed centralised distribution model for supply to independent retailers has been developed which should reduce distribution costs for the automotive component manufacturer in terms of (1 the lowest possible freight rate; (2 timely and controlled delivery; and (3 reduced congestion at the customer's receiving dock. Originality: This research is original in that it explores the possibility of implementing a centralised distribution model for independent retailers in the automotive component industry. Furthermore, there is a dearth of published research on the South African automotive component industry particularly addressing distribution issues. Conclusion: The distribution model as suggested is a practical one and should deliver added value to automotive

On the development of LWR fuel analysis code (1). Analysis of the FEMAXI code and proposal of a new model

International Nuclear Information System (INIS)

Lemehov, Sergei; Suzuki, Motoe

2000-01-01

This report summarizes the review on the modeling features of FEMAXI code and proposal of a new theoretical equation model of clad creep on the basis of irradiation-induced microstructure change. It was pointed out that plutonium build-up in fuel matrix and non-uniform radial power profile at high burn-up affect significantly fuel behavior through the interconnected effects with such phenomena as clad irradiation-induced creep, fission gas release, fuel thermal conductivity degradation, rim porous band formation and associated fuel swelling. Therefore, these combined effects should be properly incorporated into the models of the FEMAXI code so that the code can carry out numerical analysis at the level of accuracy and elaboration that modern experimental data obtained in test reactors have. Also, the proposed new mechanistic clad creep model has a general formalism which allows the model to be flexibly applied for clad behavior analysis under normal operation conditions and power transients as well for Zr-based clad materials by the use of established out-of-pile mechanical properties. The model has been tested against experimental data, while further verification is needed with specific emphasis on power ramps and transients. (author)

MO-G-17A-05: PET Image Deblurring Using Adaptive Dictionary Learning

International Nuclear Information System (INIS)

Valiollahzadeh, S; Clark, J; Mawlawi, O

2014-01-01

Purpose: The aim of this work is to deblur PET images while suppressing Poisson noise effects using adaptive dictionary learning (DL) techniques. Methods: The model that relates a blurred and noisy PET image to the desired image is described as a linear transform y=Hm+n where m is the desired image, H is a blur kernel, n is Poisson noise and y is the blurred image. The approach we follow to recover m involves the sparse representation of y over a learned dictionary, since the image has lots of repeated patterns, edges, textures and smooth regions. The recovery is based on an optimization of a cost function having four major terms: adaptive dictionary learning term, sparsity term, regularization term, and MLEM Poisson noise estimation term. The optimization is solved by a variable splitting method that introduces additional variables. We simulated a 128×128 Hoffman brain PET image (baseline) with varying kernel types and sizes (Gaussian 9×9, σ=5.4mm; Uniform 5×5, σ=2.9mm) with additive Poisson noise (Blurred). Image recovery was performed once when the kernel type was included in the model optimization and once with the model blinded to kernel type. The recovered image was compared to the baseline as well as another recovery algorithm PIDSPLIT+ (Setzer et. al.) by calculating PSNR (Peak SNR) and normalized average differences in pixel intensities (NADPI) of line profiles across the images. Results: For known kernel types, the PSNR of the Gaussian (Uniform) was 28.73 (25.1) and 25.18 (23.4) for DL and PIDSPLIT+ respectively. For blinded deblurring the PSNRs were 25.32 and 22.86 for DL and PIDSPLIT+ respectively. NADPI between baseline and DL, and baseline and blurred for the Gaussian kernel was 2.5 and 10.8 respectively. Conclusion: PET image deblurring using dictionary learning seems to be a good approach to restore image resolution in presence of Poisson noise. GE Health Care

MO-G-17A-05: PET Image Deblurring Using Adaptive Dictionary Learning

Energy Technology Data Exchange (ETDEWEB)

Valiollahzadeh, S [RICE University, Houston, Tx (United States); Clark, J [MD Anderson Cancer Ctr., Houston, TX (United States); Mawlawi, O

2014-06-15

Purpose: The aim of this work is to deblur PET images while suppressing Poisson noise effects using adaptive dictionary learning (DL) techniques. Methods: The model that relates a blurred and noisy PET image to the desired image is described as a linear transform y=Hm+n where m is the desired image, H is a blur kernel, n is Poisson noise and y is the blurred image. The approach we follow to recover m involves the sparse representation of y over a learned dictionary, since the image has lots of repeated patterns, edges, textures and smooth regions. The recovery is based on an optimization of a cost function having four major terms: adaptive dictionary learning term, sparsity term, regularization term, and MLEM Poisson noise estimation term. The optimization is solved by a variable splitting method that introduces additional variables. We simulated a 128×128 Hoffman brain PET image (baseline) with varying kernel types and sizes (Gaussian 9×9, σ=5.4mm; Uniform 5×5, σ=2.9mm) with additive Poisson noise (Blurred). Image recovery was performed once when the kernel type was included in the model optimization and once with the model blinded to kernel type. The recovered image was compared to the baseline as well as another recovery algorithm PIDSPLIT+ (Setzer et. al.) by calculating PSNR (Peak SNR) and normalized average differences in pixel intensities (NADPI) of line profiles across the images. Results: For known kernel types, the PSNR of the Gaussian (Uniform) was 28.73 (25.1) and 25.18 (23.4) for DL and PIDSPLIT+ respectively. For blinded deblurring the PSNRs were 25.32 and 22.86 for DL and PIDSPLIT+ respectively. NADPI between baseline and DL, and baseline and blurred for the Gaussian kernel was 2.5 and 10.8 respectively. Conclusion: PET image deblurring using dictionary learning seems to be a good approach to restore image resolution in presence of Poisson noise. GE Health Care.

A Proposed Educational Model to Improve the Operations of Knowledge-Exchange between MOE and Higher Education Institutions in Jordan

Directory of Open Access Journals (Sweden)

Husni Ana,am Ali Salem

2017-12-01

Full Text Available The purpose of this study was to build a proposed educational model for improving knowledge-exchange processes between the Ministry of Education and Higher Education institutions in Jordan. The sample of the study consisted of (301 educational leaders: (158 academic staff members from the Faculty of Educational Sciences – University of Jordan – and the Faculty of Education in Yarmouk University; and (143 members from the center of Jordanian Ministry of Education for the academic year 2016/2017. To achieve the aims of the study, the researcher built a questionnaire, consisting of (88 items as tool for collecting data. The research tool was checked for its validity and reliability semantics. To analyze the data, means and standard deviation were used. The results of the study showed that the educational leaders rated the degree of practicing knowledge-exchange processes between Jordanian Ministry of Education and Higher Education institutions in Jordan as (moderate. Also, they rated the obstacles that face knowledge-exchange processes as (moderate. The study concluded with a proposed educational model for improving knowledge-exchange processes between the Ministry of Education and Higher Education institutions in Jordan, and recommended to be approved and applied in Jordan. Keywords: A Proposed educational model, Knowledge-exchange processes, Practicing degree, Obstacles, Jordanian Universities, Jordanian Ministry of Education

Nanometrology, Standardization and Regulation of Nanomaterials in Brazil: A Proposal for an Analytical-Prospective Model

Directory of Open Access Journals (Sweden)

Ana Rusmerg Giménez Ledesma

2013-05-01

Full Text Available The main objective of this paper is to propose an analytical-prospective model as a tool to support decision-making processes concerning metrology, standardization and regulation of nanomaterials in Brazil, based on international references and ongoing initiatives in the world. In the context of nanotechnology development in Brazil, the motivation for carrying out this research was to identify potential benefits of metrology, standardization and regulation of nanomaterials production, from the perspective of future adoption of the model by the main stakeholders of development of these areas in Brazil. The main results can be summarized as follows: (i an overview of international studies on metrology, standardization and regulation of nanomaterials, and nanoparticles, in special; (ii the analytical-prospective model; and (iii the survey questionnaire and the roadmapping tool for metrology, standardization and regulation of nanomaterials in Brazil, based on international references and ongoing initiatives in the world.

Processes of interannual mixed layer temperature variability in the thermocline ridge of the Indian Ocean

Digital Repository Service at National Institute of Oceanography (India)

PraveenKumar, B.; Vialard, J.; Lengaigne, M.; Murty, V.S.N.; Foltz, G.R.; McPhaden, M.J.; Pous, S.; Montegut , C.deB.

, Brest Center, Pointe du Diable, B.P. 70 Plouzane 29280, France Corresponding author address: B Praveen Kumar Modelling and Ocean observations Group (MOG) Indian National Centre for Ocean Information Services (INCOIS), Hyderabad. India... SST after the end of El Niño, and to prolong its regional climate impacts (the so-called Indian Ocean “capacitor” effect). Murtugudde et al. (2000) and Du et al. (2009) did not focus on the TRIO region, but showed that a combination of vertical...

XML-based formulation of field theoretical models. A proposal for a future standard and data base for model storage, exchange and cross-checking of results

International Nuclear Information System (INIS)

Demichev, A.; Kryukov, A.; Rodionov, A.

2002-01-01

We propose an XML-based standard for formulation of field theoretical models. The goal of creation of such a standard is to provide a way for an unambiguous exchange and cross-checking of results of computer calculations in high energy physics. At the moment, the suggested standard implies that models under consideration are of the SM or MSSM type (i.e., they are just SM or MSSM, their submodels, smooth modifications or straightforward generalizations). (author)

A Proposed Model for Protein Crystal Nucleation and Growth

Science.gov (United States)

Pusey, Marc; Curreri, Peter A. (Technical Monitor)

2002-01-01

How does one take a molecule, strongly asymmetric in both shape and charge distribution, and assemble it into a crystal? We propose a model for the nucleation and crystal growth process for tetragonal lysozyme, based upon fluorescence, light, neutron, and X-ray scattering data, size exclusion chromatography experiments, dialysis kinetics, AFM, and modeling of growth rate data, from this and other laboratories. The first species formed is postulated to be a 'head to side' dimer. Through repeating associations involving the same intermolecular interactions this grows to a 4(sub 3) helix structure, that in turn serves as the basic unit for nucleation and subsequent crystal growth. High salt attenuates surface charges while promoting hydrophobic interactions. Symmetry facilitates subsequent helix-helix self-association. Assembly stability is enhanced when a four helix structure is obtained, with each bound to two neighbors. Only two unique interactions are required. The first are those for helix formation, where the dominant interaction is the intermolecular bridging anion. The second is the anti-parallel side-by-side helix-helix interaction, guided by alternating pairs of symmetry related salt bridges along each side. At this stage all eight unique positions of the P4(sub3)2(sub 1),2(sub 1) unit cell are filled. The process is one of a) attenuating the most strongly interacting groups, such that b) the molecules begin to self-associate in defined patterns, so that c) symmetry is obtained, which d) propagates as a growing crystal. Simple and conceptually obvious in hindsight, this tells much about what we are empirically doing when we crystallize macromolecules. By adjusting the growth parameters we are empirically balancing the intermolecular interactions, preferentially attenuating the dominant strong (for lysozyme the charged groups) while strengthening the lesser strong (hydrophobic) interactions. In the general case for proteins the lack of a singularly defined

A proposal of parameter determination method in the residual strength degradation model for the prediction of fatigue life (I)

International Nuclear Information System (INIS)

Kim, Sang Tae; Jang, Seong Soo

2001-01-01

The static and fatigue tests have been carried out to verify the validity of a generalized residual strength degradation model. And a new method of parameter determination in the model is verified experimentally to account for the effect of tension-compression fatigue loading of spheroidal graphite cast iron. It is shown that the correlation between the experimental results and the theoretical prediction on the statistical distribution of fatigue life by using the proposed method is very reasonable. Furthermore, it is found that the correlation between the theoretical prediction and the experimental results of fatigue life in case of tension-tension fatigue data in composite material appears to be reasonable. Therefore, the proposed method is more adjustable in the determination of the parameter than maximum likelihood method and minimization technique

Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution

Science.gov (United States)

Niida, Atsushi; Shimamura, Teppei; Hirata, Hidenari; Sugimachi, Keishi; Sawada, Genta; Iwaya, Takeshi; Kurashige, Junji; Shinden, Yoshiaki; Iguchi, Tomohiro; Eguchi, Hidetoshi; Chiba, Kenichi; Shiraishi, Yuichi; Nagae, Genta; Yoshida, Kenichi; Nagata, Yasunobu; Haeno, Hiroshi; Yamamoto, Hirofumi; Ishii, Hideshi; Doki, Yuichiro; Iinuma, Hisae; Sasaki, Shin; Nagayama, Satoshi; Yamada, Kazutaka; Yachida, Shinichi; Kato, Mamoru; Shibata, Tatsuhiro; Oki, Eiji; Saeki, Hiroshi; Shirabe, Ken; Oda, Yoshinao; Maehara, Yoshihiko; Komune, Shizuo; Mori, Masaki; Suzuki, Yutaka; Yamamoto, Ken; Aburatani, Hiroyuki; Ogawa, Seishi; Miyano, Satoru; Mimori, Koshi

2016-01-01

Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor heterogeneity is observed, from which we inferred the evolutionary history of the tumors. First, clonally shared alterations appeared, in which C>T transitions at CpG site and CpG island hypermethylation were relatively enriched. Correlation between mutation counts and patients’ ages suggests that the early-acquired alterations resulted from aging. In the late phase, a parental clone was branched into numerous subclones. Known driver alterations were observed frequently in the early-acquired alterations, but rarely in the late-acquired alterations. Consistently, our computational simulation of the branching evolution suggests that extensive intratumor heterogeneity could be generated by neutral evolution. Collectively, we propose a new model of colorectal cancer evolution, which is useful for understanding and confronting this heterogeneous disease. PMID:26890883

Ligand complex structures of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813 and its conformational change.

Science.gov (United States)

Im, Dohyun; Matsui, Daisuke; Arakawa, Takatoshi; Isobe, Kimiyasu; Asano, Yasuhisa; Fushinobu, Shinya

2018-03-01

l-Amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813 (l-AAO/MOG) catalyzes both the oxidative deamination and oxidative decarboxylation of the α-group of l-Lys to produce a keto acid and amide, respectively. l-AAO/MOG exhibits limited specificity for l-amino acid substrates with a basic side chain. We previously determined its ligand-free crystal structure and identified a key residue for maintaining the dual activities. Here, we determined the structures of l-AAO/MOG complexed with l-Lys, l-ornithine, and l-Arg and revealed its substrate recognition. Asp238 is located at the ceiling of a long hydrophobic pocket and forms a strong interaction with the terminal, positively charged group of the substrates. A mutational analysis on the D238A mutant indicated that the interaction is critical for substrate binding but not for catalytic control between the oxidase/monooxygenase activities. The catalytic activities of the D238E mutant unexpectedly increased, while the D238F mutant exhibited altered substrate specificity to long hydrophobic substrates. In the ligand-free structure, there are two channels connecting the active site and solvent, and a short region located at the dimer interface is disordered. In the l-Lys complex structure, a loop region is displaced to plug the channels. Moreover, the disordered region in the ligand-free structure forms a short helix in the substrate complex structures and creates the second binding site for the substrate. It is assumed that the amino acid substrate enters the active site of l-AAO/MOG through this route. The atomic coordinates and structure factors (codes 5YB6, 5YB7, and 5YB8) have been deposited in the Protein Data Bank (http://wwpdb.org/). 1.4.3.2 (l-amino acid oxidase), 1.13.12.2 (lysine 2-monooxygenase).

Multiple classification analysis. Theory and application to Demography

OpenAIRE

Suseł, Aleksander

2011-01-01

Model analizy klasyfikacji wielokrotnej (MCA) jest addytywnym modelem mającym szersze możliwości zastosowania niż, np. modele regresji liniowej. Przede wszystkim ze względu na to, gdyż zmienne w modelu MCA mogą pochodzić ze skal np. przedziałowej czy nominalnej. Poza tym, możliwe jest określenie stopnia wpływu zmiennych niezależnych zarówno przed jak i po uwzględnieniu zmiennych kontrolnych. Wreszcie, nie jest wymagane spełnienie założenia liniowej zależności p...

An integrated ethical approach to bioethical decision-making: A proposed model for ministers

Directory of Open Access Journals (Sweden)

Magdalena C. de Lange

2012-10-01

Full Text Available This article outlined a model for guidance in ‘doing’ bioethics in a Reformed context. The proposed model suggested that in order to arrive at responsible ethical decisions, one must refer to both contextual elements and theory. The theoretical grounding for this model was based on the integration of a deontological and virtue ethics approach, arguing that virtue enables persons to know and desire the right moral ends and motivates them to carry out appropriate action toward achieving these ends. An integrative model opens up the possibility whereby bioethics as a systematic tool provides the individual decision-maker with the critical-reflective skills and justification for the ultimate choice that is lacking in the general decision-making processes. This could lead to clearer thinking and increased confidence in the justification of decisions within the Reformed tradition. The proposed hermeneutical perspective on ethical decision-making represents a shift in views about the nature of knowledge and the process of how we come to know. The key to this hermeneutical approach is to acknowledge the dialectic between the universal and the subjectivity of human relations. Working in specific religious communities, one needs to take cognisance of the fact that knowledge is situated in the context of human relationships in which the interpreter participates when articulating the meaning of bioethical experiences. Another aspect that is anticipated lies in the realisation that people struggling with bioethical dilemmas should not be viewed as isolated individuals, but as members of a broader faith community. ‘n Geïntegreerde etiese benadering tot bioetiese besluitneming: Voorgestelde model vir predikante. Hierdie artikel het ‘n model geskets wat moontlike riglyne aantoon vir die  beoefening  van  bioetiek  binne  ‘n  Gereformeerde  konteks.  Die  voorgestelde  model argumenteer dat verwysing na beide kontekstuele elemente en teorie

Proposed Model for a Streamlined, Cohesive, and Optimized K-12 STEM Curriculum with a Focus on Engineering

Science.gov (United States)

Locke, Edward

2009-01-01

This article presents a proposed model for a clear description of K-12 age-possible engineering knowledge content, in terms of the selection of analytic principles and predictive skills for various grades, based on the mastery of mathematics and science pre-requisites, as mandated by national or state performance standards; and a streamlined,…

PROPOSAL FOR A MEASUREMENT MODEL FOR SOFTWARE TESTS WITH A FOCUS ON THE MANAGEMENT OF OUTSOURCED SERVICES

Directory of Open Access Journals (Sweden)

Angelica Toffano Seidel Calazans

2012-08-01

Full Text Available The need for outsourcing IT services has shown a significant growth over the past few years. This article presents a proposal for a measurement model for Software Tests with a focus on the management of these outsourced services by governmental organizations. The following specific goals were defined: to identify and analyze the test process; to identify and analyze the existing standards that govern the hiring of IT services and to propose a Measurement Model for outsourced services of this type. As to the analysis of the data collected (documentary research and semi-structured interviews, content analysis was adopted, and in order to prepare the metrics, the GQM – Goal, Questions, Metrics – approach was used. The result was confirmed by semi-structured interviews. Here is what the research identifies as possible: to establish objective and measurable criteria for a measurement size as the input to evaluate the efforts and deadlines involved; to follow up the test sub-processes and to evaluate the service quality. Therefore, the management of this type of service hiring can be done more efficiently.

Women's Language Model: A Proposal.

Science.gov (United States)

Dumas, Bethany K.

It is possible to think of women's language in terms of the model implied by the following statement. Insofar as native speakers of English are concerned, the language of women in America has four sets of components: those shared with the language of men in America; those shared, in varying proportions, with other women living in patriarchies;…

A Proposed Model for Measuring Performance of the University-Industry Collaboration in Open Innovation

Directory of Open Access Journals (Sweden)

Anca Draghici

2017-06-01

Full Text Available The paper aims to present a scientific approach to the creation, testing and validation of a model for performance measurement for university-industry collaboration (UIC. The main idea of the design process is to capitalize on existing success factors, facilitators and opportunities (motivation factors, knowledge transfer channels and identified benefits and to diminish or avoid potential threats and barriers that might interfere with such collaborations. The main purpose of the applied methodology is to identify solutions and measures to overcome the disadvantages, conflicts or risk issues and to facilitate the open innovation of industrial companies and universities. The methodology adopted was differentiated by two perspectives: (1 a business model reflecting the university perspective along with an inventory of key performance indicators (KPIs; (2 a performance measurement model (including performance criteria and indicators and an associated methodology (assimilated to an audit that could help companies increase collaboration with universities in the context of open innovation. In addition, in order to operationalize the proposed model (facilitating practical implementation, an Excel tool has been created to help identifying potential sources of innovation. The main contributions of the research concern the expansion of UICs knowledge to enhance open innovation and to define an effective performance measurement model and instrument (tested and validated by a case study for companies.

Real external predictivity of QSAR models: how to evaluate it? Comparison of different validation criteria and proposal of using the concordance correlation coefficient.

Science.gov (United States)

Chirico, Nicola; Gramatica, Paola

2011-09-26

The main utility of QSAR models is their ability to predict activities/properties for new chemicals, and this external prediction ability is evaluated by means of various validation criteria. As a measure for such evaluation the OECD guidelines have proposed the predictive squared correlation coefficient Q(2)(F1) (Shi et al.). However, other validation criteria have been proposed by other authors: the Golbraikh-Tropsha method, r(2)(m) (Roy), Q(2)(F2) (Schüürmann et al.), Q(2)(F3) (Consonni et al.). In QSAR studies these measures are usually in accordance, though this is not always the case, thus doubts can arise when contradictory results are obtained. It is likely that none of the aforementioned criteria is the best in every situation, so a comparative study using simulated data sets is proposed here, using threshold values suggested by the proponents or those widely used in QSAR modeling. In addition, a different and simple external validation measure, the concordance correlation coefficient (CCC), is proposed and compared with other criteria. Huge data sets were used to study the general behavior of validation measures, and the concordance correlation coefficient was shown to be the most restrictive. On using simulated data sets of a more realistic size, it was found that CCC was broadly in agreement, about 96% of the time, with other validation measures in accepting models as predictive, and in almost all the examples it was the most precautionary. The proposed concordance correlation coefficient also works well on real data sets, where it seems to be more stable, and helps in making decisions when the validation measures are in conflict. Since it is conceptually simple, and given its stability and restrictiveness, we propose the concordance correlation coefficient as a complementary, or alternative, more prudent measure of a QSAR model to be externally predictive.

Proposing an Environmental Excellence Self-Assessment Model

DEFF Research Database (Denmark)

Meulengracht Jensen, Peter; Johansen, John; Wæhrens, Brian Vejrum

2013-01-01

that the EEA model can be used in global organizations to differentiate environmental efforts depending on the maturity stage of the individual sites. Furthermore, the model can be used to support the decision-making process regarding when organizations should embark on more complex environmental efforts......This paper presents an Environmental Excellence Self-Assessment (EEA) model based on the structure of the European Foundation of Quality Management Business Excellence Framework. Four theoretical scenarios for deploying the model are presented as well as managerial implications, suggesting...

A proposal of constitutive creep model for soft rock to be applied to numerical analysis for mechanical interaction in the underground facilities

International Nuclear Information System (INIS)

Sawada, Masataka; Okada, Tetsuji

2005-01-01

In the case that the underground facilities of high-level nuclear waste disposal are constructed in soft rock mass, it is predicted that time-dependent behavior of rock has an important role both on the stability of surrounding rock mass after excavation and on the super long-term stability of barrier system. Existing creep model that has been applied to excavation problems in electric power industry is not sufficient in order to evaluate long-term behavior of the facility constructed in soft rock mass. Therefore, it is necessary to develop an appropriate creep model for soft rock. In this research, we try to develop a prototype of numerical tool for evaluating the stability during and after the excavation and super long-term stability after back-filling. Firstly, a simple rheological model for time-dependent behavior of soft rock is proposed. It is the key feature of this model that two different types of rheological model can be selected in order to describe both failure and non-failure processes. Rock continues to deform until failure in the case where stress applied to the rock exceeds its residual strength, although deformation of the rock finally ceases in the other cases. The applicability of this model is investigated by comparing the calculated results with those in laboratory test results. The proposed model can describe the time-dependent and dilatancy behavior of mudstone of Tertiary period observed in the drained triaxial creep test. Next, we apply the proposed model to the problem of time-dependent behavior of rock mass around a deposition hole. Numerical simulation of excavation problem and long-term mechanical interaction between buffer material and surrounding rock mass is carried out using a hydrological - mechanical coupled FEM code that includes the proposed model. Several mechanical models can be selected in order to apply to the mechanical behavior of materials consisting of underground facility. The main results obtained from this simulation

Proposal of a probabilistic dose-response model

International Nuclear Information System (INIS)

Barrachina, M.

1997-01-01

A biologically updated dose-response model is presented as an alternative to the linear-quadratic model currently in use for cancer risk assessment. The new model is based on the probability functions for misrepair and/or unrepair of DNA lesions, in terms of the radiation damage production rate in the cell (supposedly, a stem cell) and its repair-rate constant. The model makes use, interpreting it on the basis of misrepair probabilities, of the ''dose and dose-rate effectiveness factor'' of ICRP, and provides the way for a continuous extrapolation between the high and low dose-rate regions, ratifying the ''linear non-threshold hypothesis'' as the main option. Anyhow, the model throws some doubts about the additive property of the dose. (author)

A data envelopment analysis based model for proposing safety improvements: a FMEA approach

International Nuclear Information System (INIS)

Garcia, Pauli A. de A.; Barbosa Junior, Gilberto V.; Melo, P.F. Frutuoso e

2005-01-01

When performing a probabilistic safety assessment, one important step is the identification of the critical or weak points of all systems to be considered. By properly ranking these critical points, improvement recommendations may be proposed, in order to reduce the associated risks. Many tools are available for the identification of critical points, like the Failure Mode and Effect Analysis (FMEA) and the Hazard and Operability Studies (HAZOP). Once the failure modes or deviations are identified, indices associated to the occurrence probabilities, detection potential, and the effects severity, are assigned to them, and so the failure modes or deviations ranking is performed. It is common practice to assign risk priority numbers for this purpose. These numbers are obtained by multiplying the three aforementioned indices, which typically vary from 1 to 10 (natural numbers). Here, the greater the index, the worst the situation. In this paper, a data envelopment analysis (DEA) based model is used to identify the most critical failure modes or deviations and, by means of their respective distances to the boundary, to assess the improvement percentage for each index of each failure mode or deviation. Starting from this identification procedure, the decision maker can more efficiently propose improvement actions, like reliability allocation, detection design, protective barriers, etc. (author)

Proposal for a New Model for Highway Records in the Republic of Croatia

Directory of Open Access Journals (Sweden)

Rinaldo Paar

2012-05-01

Full Text Available Highways are public roads, whose function is to integrate Croatia in the European transport system, link the regions of Croatia and facilitate transit traffic. They are public property for general use, owned by the Republic of Croatia, and they cannot be the subject of acquisition or other proprietary rights of any kind. Today, there are two types of highway record-keeping. The first is conducted by leading companies authorised to manage highways in order to develop a highway database, or create a highway register. The second is conducted by land-management systems; the Cadastre and Land Registry. They are the official public registers for keeping records of land plots, buildings and other structures, and their ownership. Procedures that need to be implemented in the second type of record-keeping often get "stuck" in practice. Based on the problems identified in this model and an analysis of the state of record-keeping, a proposal for a new model for highway records in the Cadastre and Land Registry is given. Keywords: highways; building plot; expropriation; record; Cadastre; Land Registry

78 FR 51170 - Proposed Collection; Comment Request

Science.gov (United States)

2013-08-20

.... This is a very narrow customer base composed of Federally Funded Academic Research and Development... more information on this proposed information collection or to obtain a copy of the proposal and... the dissemination of research and development chemical, biological, radiological and nuclear modeling...

Self-gated fetal cardiac MRI with tiny golden angle iGRASP: A feasibility study.

Science.gov (United States)

Haris, Kostas; Hedström, Erik; Bidhult, Sebastian; Testud, Frederik; Maglaveras, Nicos; Heiberg, Einar; Hansson, Stefan R; Arheden, Håkan; Aletras, Anthony H

2017-07-01

To develop and assess a technique for self-gated fetal cardiac cine magnetic resonance imaging (MRI) using tiny golden angle radial sampling combined with iGRASP (iterative Golden-angle RAdial Sparse Parallel) for accelerated acquisition based on parallel imaging and compressed sensing. Fetal cardiac data were acquired from five volunteers in gestational week 29-37 at 1.5T using tiny golden angles for eddy currents reduction. The acquired multicoil radial projections were input to a principal component analysis-based compression stage. The cardiac self-gating (CSG) signal for cardiac gating was extracted from the acquired radial projections and the iGRASP reconstruction procedure was applied. In all acquisitions, a total of 4000 radial spokes were acquired within a breath-hold of less than 15 seconds using a balanced steady-state free precession pulse sequence. The images were qualitatively compared by two independent observers (on a scale of 1-4) to a single midventricular cine image from metric optimized gating (MOG) and real-time acquisitions. For iGRASP and MOG images, good overall image quality (2.8 ± 0.4 and 2.6 ± 1.3, respectively, for observer 1; 3.6 ± 0.5 and 3.4 ± 0.9, respectively, for observer 2) and cardiac diagnostic quality (3.8 ± 0.4 and 3.4 ± 0.9, respectively, for observer 1; 3.6 ± 0.5 and 3.6 ± 0.9, respectively, for observer 2) were obtained, with visualized myocardial thickening over the cardiac cycle and well-defined myocardial borders to ventricular lumen and liver/lung tissue. For iGRASP, MOG, and real time, left ventricular lumen diameter (14.1 ± 2.2 mm, 14.2 ± 1.9 mm, 14.7 ± 1.1 mm, respectively) and wall thickness (2.7 ± 0.3 mm, 2.6 ± 0.3 mm, 3.0 ± 0.4, respectively) showed agreement and no statistically significant difference was found (all P > 0.05). Images with iGRASP tended to have higher overall image quality scores compared with MOG and particularly

Social Security reform: evaluating current proposals. Latest results of the EBRI-SSASIM2 policy simulation model.

Science.gov (United States)

Copeland, C; VanDerhei, J; Salisbury, D L

1999-06-01

The present Social Security program has been shown to be financially unsustainable in the future without modification to the current program. The purpose of this Issue Brief, EBRI's fourth in a series on Social Security reform, is threefold: to illustrate new features of the EBRI-SSASIM2 policy simulation model not available in earlier EBRI publications, to expand quantitative analysis to specific proposals, and to evaluate the uncertainty involved in proposals that rely on equity investment. This analysis compares the Gregg/Breaux-Kolbe/Stenholm (GB-KS) and Moynihan/Kerrey proposals with three generic or "traditional" reforms: increasing taxes, reducing benefits, and/or increasing the retirement age. Both proposals would create individual accounts by "carving out" funds from current Social Security payroll taxes. This analysis also examines other proposed changes that would "add on" to existing Social Security funds through the use of general revenue transfers and/or investment in the equities market. President Clinton has proposed a general revenue transfer and the collective investment of some of the OASDI trust fund assets in equities. Reps. Archer and Shaw have proposed a general revenue tax credit to establish individual accounts that would be invested partially in the equities markets. When comparing Social Security reform proposals that would specifically alter benefit levels, the Moynihan/Kerrey bill compares quite favorably with the other proposals in both benefit levels and payback ratios, when individuals elect to use the individual account option. In contrast, the GB-KS bills do not compare quite as favorably for their benefit levels, but do compare favorably in terms of payback ratios. An important comparison in these bills is the administrative costs of managing the individual accounts, since benefits can be lowered by up to 23 percent when going from the assumed low to high administrative costs. Moreover, allowing individuals to decide whether to

A System Thinking Model Proposal for Enterprise Application Integration (EAI Evaluation Completeness

Directory of Open Access Journals (Sweden)

Irene Nakiyimba

2014-01-01

Full Text Available Research has identified a number of approaches for evaluating Enterprise Application Integration (EAI. The majority of these approaches focus primarily on the technical functional and non-functional capabil¬ities of an EAI solution. Although, where the technical dimensions have received considerable attention from researchers, other dimensions needed for EAI evaluation, such as stakeholder feedback, have not re¬ceived explicit consideration. As a result, attaining a consummate EAI solution is still a major challenge for many enterprises. The current EAI evaluation models simply provide piecemeal insights towards the evaluation criteria variables from limited stakeholder perceptions and do not help to understand EAI evaluation as a dynamic, feedback, time based and non-linear problem. Different stakeholders view the outcome of an EAI project from different perspectives and therefore will more likely than not arrive at different conclusions. To achieve a consensus among stakeholder perceptions, we represent EAI evaluation as a feedback analysis problem from multi-stakeholder perceptions for proper alignment with business goals, vision and mission. This paper proposes the application of System Dynamics (SD model towards guiding policy analysis for evaluating criteria factors from multi-stakeholders perceptions for EAI adoption; this will provide for holistic evaluation where emphasis is the importance of evaluation as whole (not piece meal perceptions and the interdependence of evaluation criteria factors from the diverse stakeholder perceptions is analyzed. In this paper we present a case-study performed at a large portion of the East African banking system. A total of 800 responses to questionnaires are analyzed to formulate a systems thinking model, which in turn allows us to analyze feedback loops between different stakeholders with distinct evaluation criteria. Findings result in a structured and holistic systems thinking model which

Proposing a model for limiting earning management practices: The case of Jordanian listed firms

Directory of Open Access Journals (Sweden)

Dea’a Al-Deen Al-Sraheen

2016-11-01

Full Text Available The key objective of this paper is to propose a model for limiting earning management practices among manufacturing firms in Jordan. In order to do so, two independent variables are examined in this paper, namely, political influence and CEO Duality. Discretionary total accruals according to the modified Jones model (1991 was used in order to estimate the level of earnings management, which is the dependent variable. The sample comprised 64 companies for the financial year 2013. The results suggest that a positive and significant association existed among both political influence and CEO duality and earning management. This means that both independent variables exacerbated earnings management. Further research is required to determine what urgent legislation should be developed to restrict the presence of members who have political connections on the board of directors. Also, the need exists for the separation of roles of Chairman and CEO to ensure the independence and complying with the requirements of corporate governance.

Cognitive processes and neural basis of language switching: proposal of a new model.

Science.gov (United States)

Moritz-Gasser, Sylvie; Duffau, Hugues

2009-12-09

Although studies on bilingualism are abundant, cognitive processes and neural foundations of language switching received less attention. The aim of our study is to provide new insights to this still open question: do dedicated region(s) for language switching exist or is this function underlain by a distributed circuit of interconnected brain areas, part of a more general cognitive system? On the basis of recent behavioral, neuroimaging, and brain stimulation studies, we propose an original 'hodological' model of language switching. This process might be subserved by a large-scale cortico-subcortical network, with an executive system (prefrontal cortex, anterior cingulum, caudate nucleus) controlling a more dedicated language subcircuit, which involves postero-temporal areas, supramarginal and angular gyri, Broca's area, and the superior longitudinal fasciculus.

Računarsko modelovanje samonavođene rakete sa pokretnim pratećim koordinatorom / Computer modeling of homing systems with a mobile accompanying coordinator

Directory of Open Access Journals (Sweden)

Stojadin Manojlović

2003-03-01

Full Text Available Sistemi vođenja i upravljanja raketama uopšte, uključujući i sisteme samovođenja kao njihov poseban oblik, složeni su sistemi koji zahtevaju primenu znanja iz vise oblasti, kako bi na precizan način mogli da se formiraju što realniji matematički modeli svih strukturnih elemenata. Na osnovu matematičkog modela moguće je stvoriti računarski model pomoću kojeg se vrši analiza dinamičkog ponašanja sistema. U ovom radu predstavljeno je programsko rešenje za modelovanje sistema samovođenja zasnovano na programskom jeziku MATLAB. Rešenje je implementirano na modularnom principu, što omogućava lakšu kontrolu eventualnih grešaka i olakšava nadogradnju novim komponentama, npr. drugi tip zakona vođenja. / Guidance and control systems, including homing systems, are complex systems requiring the application of knowledge from different areas in order to form precise mathematical models of all system elements. The computer model is based on the mathematical model of a homing system and it enables the system dynamical performance analysis. In this paper a computer model of the homing system is presented. The described software is open for upgrade, i.e. for another type of the guidance law.

Information-sharing to promote informed choice in prenatal screening in the spirit of the SOGC clinical practice guideline: a proposal for an alternative model.

Science.gov (United States)

Vanstone, Meredith; Kinsella, Elizabeth Anne; Nisker, Jeff

2012-03-01

The 2011 SOGC clinical practice guideline "Prenatal Screening for Fetal Aneuploidy in Singleton Pregnancies" recommends that clinicians offer prenatal screening to all pregnant women and provide counselling in a non-directive manner. Non-directive counselling is intended to facilitate autonomous decision-making and remove the clinician's views regarding a particular course of action. However, recent research in genetic counselling raises concerns that non-directive counselling is neither possible nor desirable, and that it may not be the best way to facilitate informed choice. We propose an alternative model of information-sharing specific to prenatal screening that combines attributes of the models of informative decision-making and shared decision-making. Our proposed model is intended to provide clinicians with a strategy to communicate information about prenatal screening in a way that facilitates a shared deliberative process and autonomous decision-making. Our proposed model may better prepare a pregnant woman to make an informed choice about participating in prenatal screening on the basis of her consideration of the medical information provided by her clinician and her particular circumstances and values.

a Proposal for Generalization of 3d Models

Science.gov (United States)

Uyar, A.; Ulugtekin, N. N.

2017-11-01

In recent years, 3D models have been created of many cities around the world. Most of the 3D city models have been introduced as completely graphic or geometric models, and the semantic and topographic aspects of the models have been neglected. In order to use 3D city models beyond the task, a generalization is necessary. CityGML is an open data model and XML-based format for the storage and exchange of virtual 3D city models. Level of Details (LoD) which is an important concept for 3D modelling, can be defined as outlined degree or prior representation of real-world objects. The paper aim is first describes some requirements of 3D model generalization, then presents problems and approaches that have been developed in recent years. In conclude the paper will be a summary and outlook on problems and future work.

Proposal for a model to assess the effect of seismic activity on the triggering of debris flows

Science.gov (United States)

Vidar Vangelsten, Bjørn; Liu, Zhongqiang; Eidsvig, Unni; Luna, Byron Quan; Nadim, Farrokh

2013-04-01

Landslide triggered by earthquakes is a serious threat for many communities around the world, and in some cases is known to have caused 25-50% of the earthquake fatalities. Seismic shaking can contribute to the triggering of debris flows either during the seismic event or indirectly by increasing the susceptibility of the slope to debris flow during intense rainfall in a period after the seismic event. The paper proposes a model to quantify both these effects. The model is based on an infinite slope formulation where precipitation and earthquakes influence the slope stability as follows: (1) During the shaking, the factor of safety is reduced due to cyclic pore pressure build-up where the cyclic pore pressure is modelled as a function of earthquake duration and intensity (measured as number of equivalent shear stress cycles and cyclic shear stress magnitude) and in-situ soil conditions (measured as average normalised shear stress). The model is calibrated using cyclic triaxial and direct simple shear (DSS) test data on clay and sand. (2) After the shaking, the factor of safety is modified using a combined empirical and analytical model that links observed earthquake induced changes in rainfall thresholds for triggering of debris flow to an equivalent reduction in soil shear strength. The empirical part uses data from past earthquakes to propose a conceptual model linking a site-specific reduction factor for rainfall intensity threshold (needed to trigger debris flows) to earthquake magnitude, distance from the epicentre and time period after the earthquake. The analytical part is a hydrological model for transient rainfall infiltration into an infinite slope in order to translate the change in rainfall intensity threshold into an equivalent reduction in soil shear strength. This is generalised into a functional form giving a site-specific shear strength reduction factor as function of earthquake history and soil conditions. The model is suitable for hazard and risk

An analysis of a three-factor model proposed by the Danish Society of Actuaries for forecasting and risk analysis

DEFF Research Database (Denmark)

Jørgensen, Peter Løchte; Slipsager, Søren Kærgaard

2016-01-01

This paper provides the explicit solution to the three-factor diffusion model recently proposed by the Danish Society of Actuaries to the Danish industry of life insurance and pensions. The solution is obtained by use of the known general solution to multidimensional linear stochastic differential...

Dokumenty piśmiennicze w grach komputerowych. Funkcje i forma

OpenAIRE

Przemysław Ciszek

2012-01-01

Abstrakt w j. polskim:Książki i inne dokumenty piśmiennicze (czasopisma, pamiętniki czy listy) występują w wielu grach wideo. Szczególnie często można je znaleźć w grach cRPG (fabularne gry komputerowe) i przygodowych, które to pozwalają na dużą interakcję ze światem gry. Książki mogą pełnić w grach podobne funkcje jak w świecie rzeczywistym – funkcję poznawczą i rozrywkową. Książki i dokumenty mogą zawierać treść dostępną dla gracza, ale wiele z nich oddziałuje jedynie na awatara w grze. Eng...

Regulation of Th1 and Th17 cell differentiation and amelioration of experimental autoimmune encephalomyelitis by natural product compound berberine.

Science.gov (United States)

Qin, Xia; Guo, Bingshi T; Wan, Bing; Fang, Lei; Lu, Limin; Wu, Lili; Zang, Ying Qin; Zhang, Jingwu Z

2010-08-01

Berberine (BBR), an isoquinoline alkaloid derived from plants, is widely used as an anti-inflammatory remedy in traditional Chinese medicine. In this study, we showed that BBR was efficacious in the amelioration of experimental autoimmune encephalomyelitis (EAE) through novel regulatory mechanisms involving pathogenic Th1 and Th17 cells. BBR inhibited differentiation of Th17 cells and, to a lesser degree, Th1 cells through direct actions on the JAK/STAT pathway, whereas it had no effect on the relative number of CD4(+)Foxp3(+) regulatory T cells. In addition, BBR indirectly influenced Th17 and Th1 cell functions through its effect on the expression and function of costimulatory molecules and the production of IL-6, which was attributable to the inhibition of NF-kappaB activity in CD11b(+) APCs. BBR treatment completely abolished the encephalitogenicity of MOG(35-55)-reactive Th17 cells in an adoptive transfer EAE model, and the same treatment significantly inhibited the ability of MOG(35-55)-reactive Th1 cells to induce EAE. This study provides new evidence that natural compounds, such as BBR, are of great value in the search for novel anti-inflammatory agents and therapeutic targets for autoimmune diseases.

RAMI modeling of selected balance of plant systems for the proposed Accelerator Production of Tritium (APT) project

International Nuclear Information System (INIS)

Radder, J.A.; Cramer, D.S.

1997-01-01

In order to meet Department of Energy (DOE) Defense Program requirements for tritium in the 2005-2007 time frame, new production capability must be made available. The Accelerator Production of Tritium (APT) Plant is being considered as an alternative to nuclear reactor production of tritium, which has been the preferred method in the past. The proposed APT plant will use a high-power proton accelerator to generate thermal neutrons that will be captured in 3 He to produce tritium (3H). It is expected that the APT Plant will be built and operated at the DOE's Savannah River Site (SRS) in Aiken, South Carolina. Discussion is focused on Reliability, Availability, Maintainability, and Inspectability (RAMI) modeling of recent conceptual designs for balance of plant (BOP) systems in the proposed APT Plant. In the conceptual designs for balance of plant (BOP) systems in the proposed APT Plant. In the conceptual design phase, system RAMI estimates are necessary to identify the best possible system alternative and to provide a valid picture of the cost effectiveness of the proposed system for comparison with other system alternatives. RAMI estimates in the phase must necessarily be based on generic data. The objective of the RAMI analyses at the conceptual design stage is to assist the designers in achieving an optimum design which balances the reliability and maintainability requirements among the subsystems and components

Self-rated health, multimorbidity and depression in Mexican older adults: Proposal and evaluation of a simple conceptual model.

Science.gov (United States)

Bustos-Vázquez, Eduardo; Fernández-Niño, Julián Alfredo; Astudillo-Garcia, Claudia Iveth

2017-04-01

Self-rated health is an individual and subjective conceptualization involving the intersection of biological, social and psychological factors. It provides an invaluable and unique evaluation of a person's general health status. To propose and evaluate a simple conceptual model to understand self-rated health and its relationship to multimorbidity, disability and depressive symptoms in Mexican older adults. We conducted a cross-sectional study based on a national representative sample of 8,874 adults of 60 years of age and older. Self-perception of a positive health status was determined according to a Likert-type scale based on the question: "What do you think is your current health status?" Intermediate variables included multimorbidity, disability and depressive symptoms, as well as dichotomous exogenous variables (sex, having a partner, participation in decision-making and poverty). The proposed conceptual model was validated using a general structural equation model with a logit link function for positive self-rated health. A direct association was found between multimorbidity and positive self-rated health (OR=0.48; 95% CI: 0.42-0.55), disability and positive self-rated health (OR=0.35; 95% CI: 0.30-0.40), depressive symptoms and positive self-rated health (OR=0.38; 95% CI: 0.34-0.43). The model also validated indirect associations between disability and depressive symptoms (OR=2.25; 95% CI: 2.01- 2.52), multimorbidity and depressive symptoms (OR=1.79; 95% CI: 1.61-2.00) and multimorbidity and disability (OR=1.98; 95% CI: 1.78-2.20). A parsimonious theoretical model was empirically evaluated, which enabled identifying direct and indirect associations with positive self-rated health.

SST: Single-Stream Temporal Action Proposals

KAUST Repository

Buch, Shyamal; Escorcia, Victor; Shen, Chuanqi; Ghanem, Bernard; Niebles, Juan Carlos

2017-01-01

Our paper presents a new approach for temporal detection of human actions in long, untrimmed video sequences. We introduce Single-Stream Temporal Action Proposals (SST), a new effective and efficient deep architecture for the generation of temporal action proposals. Our network can run continuously in a single stream over very long input video sequences, without the need to divide input into short overlapping clips or temporal windows for batch processing. We demonstrate empirically that our model outperforms the state-of-the-art on the task of temporal action proposal generation, while achieving some of the fastest processing speeds in the literature. Finally, we demonstrate that using SST proposals in conjunction with existing action classifiers results in improved state-of-the-art temporal action detection performance.

SST: Single-Stream Temporal Action Proposals

KAUST Repository

Buch, Shyamal

2017-11-09

Our paper presents a new approach for temporal detection of human actions in long, untrimmed video sequences. We introduce Single-Stream Temporal Action Proposals (SST), a new effective and efficient deep architecture for the generation of temporal action proposals. Our network can run continuously in a single stream over very long input video sequences, without the need to divide input into short overlapping clips or temporal windows for batch processing. We demonstrate empirically that our model outperforms the state-of-the-art on the task of temporal action proposal generation, while achieving some of the fastest processing speeds in the literature. Finally, we demonstrate that using SST proposals in conjunction with existing action classifiers results in improved state-of-the-art temporal action detection performance.

A proposed model for assessing service quality in small machining and industrial maintenance companies

Directory of Open Access Journals (Sweden)

Morvam dos Santos Netto

2014-11-01

Full Text Available Machining and industrial maintenance services include repair (corrective maintenance of equipments, activities involving the assembly-disassembly of equipments, fault diagnosis, machining operations, forming operations, welding processes, assembly and test of equipments. This article proposes a model for assessing the quality of services provided by small machining and industrial maintenance companies, since there is a gap in the literature regarding this issue and because the importance of small service companies in socio-economic development of the country. The model is an adaptation of the SERVQUAL instrument and the criteria determining the quality of services are designed according to the service cycle of a typical small machining and industrial maintenance company. In this sense, the Moments of Truth have been considered in the preparation of two separate questionnaires. The first questionnaire contains 24 statements that reflect the expectations of customers, and the second one contains 24 statements that measure perceptions of service performance. An additional item was included in each questionnaire to assess, respectively, the overall expectation about the services and the overall company performance. Therefore, it is a model that considers the interfaces of the client/supplier relationship, the peculiarities of the machining and industrial maintenance service sector and the company size.

3-Dimensional Flow Modeling of a Proposed Hanford Waste Treatment Plant Ion-Exchange Column Design

International Nuclear Information System (INIS)

ALEMAN, SEBASTIAN

2002-01-01

Historically, it has been assumed that the inlet and outlet low activity waste plenums would be designed such that a nearly uniform velocity profile would be maintained at every axial cross-section (i.e., providing nearly 100 percent use of the resin bed). With this proposed design, we see a LAW outlet distributor that results in significant non-axial velocity gradients in the bottom regions of the bed with the potential to reduce the effectiveness'' of the overall resin bed. The magnitude of this efficiency reduction depends upon how far up-gradient of the LAW outlet these non-axial velocities persist and to what extent a ''dead-zone'' is established beneath the LAW outlet. This can impact loading and elution performance of the ion-exchange facility. Currently, no experimental studies are planned. The primary objective of this work was, through modeling, to assess the fluid dynamic impact on ''effective'' resin volume of the full-scale column based on its normal operation using a recently proposed LAW outlet distributor. The analysis effort was limited to 3-D flow only analyses (i.e., no follow on transport analyses) with 3-D particle tracking to approximate the impact that a nonaxial velocity profile would have on bed ''effectiveness''. Additional analyses were performed to estimate under nominal operating conditions the thermal temperature rise across a loaded resin bed and within its particles. Hydrogen bubble formation is not considered in the heat transfer analysis or in the determination of minimum flowrate. All modeling objectives were met

Circulation Modeling for Proposed Port Facility at Ponce and Guayanilla, Puerto Rico

National Research Council Canada - National Science Library

Scheffner, Norman

2002-01-01

... of Ponce and Guayanilla, Puerto Rico. Impacts of the proposed construction were determined by conducting numerical simulations of tidal and storm surge circulation at the project sites using with and without the proposed port facilities...

The Proposal Concept of Development and Implementation in Strategy of Sustainable Corporate Social Responsibility in the Context of the HCS Model 3E

Science.gov (United States)

Sakál, Peter; Hrdinová, Gabriela

2016-06-01

This article is the result of a conceptual design methodology for the development of a sustainable strategy of sustainable corporate social responsibility (SCSR) in the context of the HCS model 3E formed, as a co-author within the stated grants and dissertation. On the basis of the use of propositional logic, the SCSR procedure is proposed for incorporation into the corporate strategy of sustainable development and the integrated management system (IMS) of the industrial enterprise. The aim of this article is the proposal of the concept of development and implementation strategy of SCSR in the context of the HCS model 3E.

On the scale similarity in large eddy simulation. A proposal of a new model

International Nuclear Information System (INIS)

Pasero, E.; Cannata, G.; Gallerano, F.

2004-01-01

validity of the proposed model was tested through channel flow simulation with friction-velocity-based Reynolds numbers ranging from 180 to 2340. (author)

A Proposed Model for Selecting Measurement Procedures for the Assessment and Treatment of Problem Behavior.

Science.gov (United States)

LeBlanc, Linda A; Raetz, Paige B; Sellers, Tyra P; Carr, James E

2016-03-01

Practicing behavior analysts frequently assess and treat problem behavior as part of their ongoing job responsibilities. Effective measurement of problem behavior is critical to success in these activities because some measures of problem behavior provide more accurate and complete information about the behavior than others. However, not every measurement procedure is appropriate for every problem behavior and therapeutic circumstance. We summarize the most commonly used measurement procedures, describe the contexts for which they are most appropriate, and propose a clinical decision-making model for selecting measurement produces given certain features of the behavior and constraints of the therapeutic environment.

Transverse Myelitis Association

Science.gov (United States)

... INSPIRATION What is Anti-Myelin Oligodendrocyte Glycoprotein (MOG)? https://myelitis.org/wp-content/uploads/2015/05/blog_research.jpg 999 1500 The TMA https://myelitis.org/wp-content/uploads/2015/06/TMA- ...

Preference and strategy in proposer's prosocial giving in the ultimatum game.

Science.gov (United States)

Inaba, Misato; Inoue, Yumi; Akutsu, Satoshi; Takahashi, Nobuyuki; Yamagishi, Toshio

2018-01-01

The accumulation of findings that most responders in the ultimatum game reject unfair offers provides evidence that humans are driven by social preferences such as preferences for fairness and prosociality. On the other hand, if and how the proposer's behavior is affected by social preferences remains unelucidated. We addressed this question for the first time by manipulating the knowledge that the proposer had about the responder's belief concerning the intentionality of the proposer. In a new game called the "ultimatum game with ambiguous intentions of the proposer (UGAMB)," we made the intentionality of the proposer ambiguous to the recipient. We expected and found that the proposer would make more unfair offers in this new game than in the standard ultimatum game. This expectation can be derived from either the preference-based model or the strategy model of the proposer's giving decision. The additional finding that more unfair giving in the UGAMB was not mediated by the proposer's expectation that the recipient would be more willing to accept unfair offers provided support for the preference-based model. Using a psychological measure of cognitive control, the preference-based model received additional support through a conceptual replication of the previous finding that cognitive control of intuitive drive for prosociality in the dictator game, rather than mind reading in the ultimatum game, is responsible for the difference in giving between the two games.

Prioritization Scheme for Proposed Road Weather Information System Sites: Montana Case Study

Directory of Open Access Journals (Sweden)

Ahmed Al-Kaisy

2017-08-01

Full Text Available A model for prioritization of new proposed environmental sensor station (ESS sites is developed and presented in this paper. The model assesses the overall merit (OM of a proposed ESS site as part of a Road Weather Information System (RWIS using weather, traffic, and safety data among other variables. The purpose of the proposed model is to help in selecting optimum sites for new ESS locations, which is important in guiding RWIS system expansion. Inputs to the OM model include weather index (WI, traffic index (TI, crash index, geographic coverage, and opportunistic factors. The WI at a proposed site is determined using multiple indicators of weather severity and variability. The crash index, another major input to the OM model, incorporates crash rate along the route and the percentage of weather-related crashes over the analysis period. The TI, in turn, reflects the amount of travel on the highway network in the area surrounding the proposed ESS site. The fourth input to the merit model accounts for the ESS existing coverage in the area where the proposed site is located, while the fifth and last input is concerned with the availability and ease of access to power and communications. Model coefficients are represented by weights that reflect the contribution of each input (variable to the OM of the ESS site. Those weights are user-specified and should be selected to reflect the agency preferences and priorities. The application of the proposed merit model on sample sites in Montana demonstrated the utility of the model in ranking candidate sites using data readily available to highway agencies.

Characterization of Antigen-Specific B Cells Using Nominal Antigen-Coated Flow-Beads

Science.gov (United States)

Akl, Ahmed; Lepetit, Maud; Crochette, Romain; Giral, Magali; Lepourry, Julie; Pallier, Annaick; Castagnet, Stéphanie; Dugast, Emilie; Guillot-Gueguen, Cécile; Jacq-Foucher, Marylène; Saulquin, Xavier; Cesbron, Anne; Laplaud, David; Nicot, Arnaud; Brouard, Sophie; Soulillou, Jean-Paul

2013-01-01

In order to characterize the reactivity of B cells against nominal antigens, a method based on the coupling of antigens onto the surface of fluorescent core polystyrene beads was developed. We first demonstrate that murine B cells with a human MOG-specific BCR are able to interact with MOG-coated beads and do not recognize beads coated with human albumin or pp65. B cells purified from human healthy volunteer blood or immunized individuals were tested for their ability to interact with various nominal antigens, including viral, vaccine, self and alloantigens, chosen for their usefulness in studying a variety of pathological processes. A substantial amount of B cells binding self-antigen MOG-coated beads can be detected in normal blood. Furthermore, greater frequencies of B cell against anti-Tetanic Toxin or anti-EBNA1 were observed in primed individuals. This method can reveal increased frequencies of anti-HLA committed B cells in patients with circulating anti-HLA antibodies compared to unsensitized patients and normal individuals. Of interest, those specific CD19 cells were preferentially identified within CD27−IgD+ (i-e naïve) subset. These observations suggest that a broad range of medical situations could benefit from a tool that allows the detection, the quantification and the characterization of antigen-specific blood B cells. PMID:24386360

Study on the noncoincidence effect phenomenon using matrix isolated Raman spectra and the proposed structural organization model of acetone in condense phase

Science.gov (United States)

Xu, Wenwen; Wu, Fengqi; Zhao, Yanying; Zhou, Ran; Wang, Huigang; Zheng, Xuming; Ni, Bukuo

2017-03-01

The isotropic and anisotropic Raman spectra of acetone and deuterated acetone isolated in an argon matrix have been recorded for the understanding of noncoincidence effect (NCE) phenomenon. According to the matrix isolated Raman spectra and DFT calculations, we proposed aggregated model for the explanations of the acetone C=O vibration NCE phenomenon and its concentration effect. The experimental data were in consistence with the DFT calculations performed at the B3LYP-D3/6-311 G (d,p) levels based on the proposed model. The experimental identification of the monomer, dimer and trimer are reported here, and the dynamic of the transformation from monomer to aggregated structure can be easily controlled by tuning annealing temperature.

Dynamic risk assessment method – a proposal for assessing risk in water supply system / Metoda dynamicznego szacowania ryzyka – propozycja oceny ryzyka w systemie zaopatrzenia wody

Directory of Open Access Journals (Sweden)

Fortmann-Roe Scott

2015-06-01

Full Text Available Dynamika Systemów jest metodologią modelowania i analizy złożonych systemów. Taki złożony system może być charakteryzowany przez wzajemne proste połączenia elementów oraz istniejące sprzężenia zwrotne. Przeprowadzenie oceny ryzyka przy modelowaniu Systemów Dynamicznych jest trudnym wyzwaniem. Chociaż w niektórych przypadkach, uzyskane za pomocą symulacji serie wyników mogą się wydawać przypadkowe, to jednak często istnieje wysoki stopień autokorelacji między tymi seriami wynikający z istnienia powiązań zwrotnych w systemie. Artykuł przedstawia propozycje Metody Dynamicznego Szacowania Ryzyka (MDSR, która pozwala oceniać ryzyko związane z hipotetycznymi kosztami zachorowań wywołanymi skażeniem systemu zaopatrzenia w wodę przez Cryptosporidium.

Modeling the Hydrogeochemical Transport of Radionuclides through Engineered Barriers System in the Proposed LLW Disposal Site of Taiwan - 12082

Energy Technology Data Exchange (ETDEWEB)

Lin, Wen-Sheng [Hydrotech Research Institute, National Taiwan University, Taipei, Taiwan (China); Liu, Chen-Wuing; Tsao, Jui-Hsuan [Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan (China); Li, Ming-Hsu [Institute of Hydrological and Oceanic Sciences, National Central University, Jhongli, Taiwan (China)

2012-07-01

A proposed site for final disposal of low-level radioactive waste located in Daren Township of Taitung County along the southeastern coast has been on the selected list in Taiwan. The geology of the Daren site consists of argillite and meta-sedimentary rocks. A mined cavern design with a tunnel system of 500 m below the surface is proposed. Concrete is used as the main confinement material for the engineered barrier. To investigate the hydrogeochemical transport of radionuclides through engineered barriers system, HYDROGEOCHEM5.0 model was applied to simulate the complex chemical interactions among radionuclides, the cement minerals of the concrete, groundwater flow, and transport in the proposed site. The simulation results showed that the engineered barriers system with the side ditch efficiently drained the ground water and lowered the concentration of the concrete degradation induced species (e.g., hydrogen ion, sulfate, and chloride). The velocity of groundwater observed at side ditch gradually decreased with time due to the fouling of pore space by the mineral formation of ettringite and thaumasite. The short half-life of Co-60, Sr-90 and Cs-137 significantly reduced the concentrations, whereas the long half-life of I-129(1.57x10{sup 7} years) and Am-241(432 years) remain stable concentrations at the interface of waste canister and concrete barrier after 300 years. The mineral saturation index (SI) was much less than zero due to the low aqueous concentration of radionuclide, so that the precipitation formation of Co-60, Sr-90, I-129, Cs-137 and Am-241 related minerals were not found. The effect of adsorption/desorption (i.e., surface complexation model) could be a crucial geochemical mechanism for the modeling of liquid-solid phase behavior of radionuclide in geochemically dynamic environments. Moreover, the development of advanced numerical models that are coupled with hydrogeochemical transport and dose assessment of radionuclide is required in the future

Computational Approaches to Modeling Artificial Emotion -– An overview of the Proposed Solutions

Directory of Open Access Journals (Sweden)

Zdzislaw eKOWALCZUK

2016-04-01

Full Text Available Cybernetic approach to modeling artificial emotion through the use of different theories of psychology is considered in this paper, presenting a review of twelve proposed solutions: ActAffAct, FLAME, EMA, ParleE, FearNot!, FAtiMA, WASABI, Cathexis, KARO, MAMID, FCM, and xEmotion. The main motivation for this study is founded on the hypothesis that emotions can play a definite utility role of scheduling variables in the construction of intelligent autonomous systems, agents and mobile robots. In this review we also include an innovative and panoptical, comprehensive system, referred to as the Intelligent System of Decision-making (ISD, which has been employed in practical applications of various autonomous units, and which applies as its part the xEmotion, taking into consideration the personal aspects of emotions, affects (short term emotions and mood (principally, long term emotions.

A model proposal concerning balance scorecard application integrated with resource consumption accounting in enterprise performance management

Directory of Open Access Journals (Sweden)

ORHAN ELMACI

2014-06-01

Full Text Available The present study intended to investigate the “Balance Scorecard (BSC model integrated with Resource Consumption Accounting (RCA” which helps to evaluate the enterprise as matrix structure in its all parts. It aims to measure how much tangible and intangible values (assets of enterprises contribute to the enterprises. In other words, it measures how effectively, actively, and efficiently these values (assets are used. In short, it aims to measure sustainable competency of enterprises. As expressing the effect of tangible and intangible values (assets of the enterprise on the performance in mathematical and statistical methods is insufficient, it is targeted that RCA Method integrated with BSC model is based on matrix structure and control models. The effects of all complex factors in the enterprise on the performance (productivity and efficiency estimated algorithmically with cause and effect diagram. The contributions of matrix structures for reaching the management functional targets of the enterprises that operate in market competitive environment increasing day to day, is discussed. So in the context of modern management theories, as a contribution to BSC approach which is in the foreground in today’s administrative science of enterprises in matrix organizational structures, multidimensional performance evaluation model -RCA integrated with BSC Model proposal- is presented as strategic planning and strategic evaluation instrument.

Neutronic characteristics of coupled moderator proposed in integrated model

International Nuclear Information System (INIS)

Teshigawara, Makoto; Meigo, Shin-ichiro; Sakata, Hideaki; Kai, Tetsuya; Harada, Masahide; Ikeda, Yujiro; Watanabe, Noboru

2001-05-01

A pulsed spallation source for the materials science and the life science is currently developing for its construction in the High Intensity Proton Accelerator Project proposed jointly by the Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Research Organization (KEK). This report presents the analytical results of the neutronic characteristics of the coupled moderator based on the analytical results obtained by using an integrated model which has established on the extensive neutronic and technical study. Total heat deposition in a hydrogen (H 2 ) moderator working as the main moderator was about 420 W/MW. Maximum nuclear heat density in the H 2 moderator was about 1 W/cm 3 /MW. Also total heat deposition in a premoderator was about 9.2 kW/MW. The heat density of the premoderator was comparable to that of the moderator vessel made of aluminum alloy. The heat density of the premoderator and the moderator vessel is about 1.2-2 times higher than that of the hydrogen moderator. The temperature from 300 K to 400 K of the premoderator did not affect on neutron intensity of the H 2 moderator. This suggested an engineering advantage on the thermal and hydraulic design. 6000 or 7000 type of a aluminum alloy was considered from the viewpoint of the neutron beam transmission. The proton beams scattered by the proton beam window did not affect on the nuclear heating in the H 2 moderator. The heat deposition in the H 2 moderator and the neutron intensity of the H 2 moderator did not depend on the proton beam profile but it did on the distance between the proton beam and the moderator. (author)

Proposal of performance indicators/model for Operational Readiness Verification (ORV) at restart after a planned shutdown

International Nuclear Information System (INIS)

Hollnagel, Erik; Nygren, Magnus

2005-12-01

The objectives of the study reported here were to propose a model that can be used in the analysis of possible future ORV-related events and to outline a set of performance indicators that can be used by the inspectorate to assess a utility's level of readiness if an ORV-event should take place. Together the two objectives serve to improve the inspectorate's ability to ensure that the utilities maintain an adequate capability to respond. The background for the current study is the nine ORV events that occurred in Sweden between 1995- 1998, as well as the findings of a previous study of safety during outage and restart of nuclear power plants project. This study found that the three levels or types of tests that occur in ORV were used according to need rather than according to a predefined arrangement or procedure, and that tasks were adapted relative to the different types of embedding and the degree of correspondence between nominal and actual ORV. The organisation's coping with the complexity of ORV was discussed by the relation between expectations and surprises, how planning was used as control, attention to details, and the practices of shift changes. It is a truism that accidents are analysed and interpreted relative to a commonly accepted understanding of their nature. This understanding is, however, relative rather than absolute, and has changed significantly during the last decade. In the 1990s, accidents were analysed step by step, and explanations and recommendations therefore emphasised specific rather than generic solutions. The present study illustrates this by going through the responses to the nine ORV events. Following that, the nine events are analysed anew using a contemporary understanding of accidents (a systemic model), which emphasises that incidents more often arise from context induced performance variability than from failures of people. The alternative interpretation provided by a systemic model is illustrated by a detailed analysis of

Predicting the effects of proposed Mississippi River diversions on oyster habitat quality; application of an oyster habitat suitability index model

Science.gov (United States)

Soniat, Thomas M.; Conzelmann, Craig P.; Byrd, Jason D.; Roszell, Dustin P.; Bridevaux, Joshua L.; Suir, Kevin J.; Colley, Susan B.

2013-01-01

In an attempt to decelerate the rate of coastal erosion and wetland loss, and protect human communities, the state of Louisiana developed its Comprehensive Master Plan for a Sustainable Coast. The master plan proposes a combination of restoration efforts including shoreline protection, marsh creation, sediment diversions, and ridge, barrier island, and hydrological restoration. Coastal restoration projects, particularly the large-scale diversions of fresh water from the Mississippi River, needed to supply sediment to an eroding coast potentially impact oyster populations and oyster habitat. An oyster habitat suitability index model is presented that evaluates the effects of a proposed sediment and freshwater diversion into Lower Breton Sound. Voluminous freshwater, needed to suspend and broadly distribute river sediment, will push optimal salinities for oysters seaward and beyond many of the existing reefs. Implementation and operation of the Lower Breton Sound diversion structure as proposed would render about 6,173 ha of hard bottom immediately east of the Mississippi River unsuitable for the sustained cultivation of oysters. If historical harvests are to be maintained in this region, a massive and unprecedented effort to relocate private leases and restore oyster bottoms would be required. Habitat suitability index model results indicate that the appropriate location for such efforts are to the east and north of the Mississippi River Gulf Outlet.

Numerical Differentiation Methods for Computing Error Covariance Matrices in Item Response Theory Modeling: An Evaluation and a New Proposal

Science.gov (United States)

Tian, Wei; Cai, Li; Thissen, David; Xin, Tao

2013-01-01

In item response theory (IRT) modeling, the item parameter error covariance matrix plays a critical role in statistical inference procedures. When item parameters are estimated using the EM algorithm, the parameter error covariance matrix is not an automatic by-product of item calibration. Cai proposed the use of Supplemented EM algorithm for…

Proposing a New Approach for Supplier Selection Based on Kraljic’s Model Using FMEA and Integer Linear Programming

Directory of Open Access Journals (Sweden)

S. Mohammad Arabzad

2012-06-01

Full Text Available In recent years, numerous methods have been proposed to deal with supplier evaluation and selection problem, but a point which has been usually neglected by researchers is the role of purchasing items. The aim of this paper is to propose an integrated approach to select suppliers and allocate orders on the basis of the nature of the purchasing items which means that this issue plays an important role in supplier selection and order allocation. Therefore, items are first categorized according to the Kraljic’s model by the use of FMEA technique. Then, suppliers are categorized and evaluated in four phases with respect to different types of purchasing items (Strategic, Bottleneck, Leverage and Routine. Finally, an integer linear programming is utilized to allocate purchasing orders to suppliers. Furthermore, an empirical example is conducted to illustrate the stage of proposed approach. Results imply that ranking of suppliers and allocation of purchasing items based on the nature of purchasing items will create more capabilities in managing purchasing items and suppliers .

Proposed Model of Predicting the Reduced Yield Axial Load of Reinforced Concrete Columns Due to Casting Deficiency Effect

Directory of Open Access Journals (Sweden)

Achillopoulou Dimitra

2014-12-01

Full Text Available The study deals with the investigation of the effect of casting deficiencies- both experimentally and analytically on axial yield load or reinforced concrete columns. It includes 6 specimens of square section (150x150x500 mm of 24.37 MPa nominal concrete strength with 4 longitudinal steel bars of 8 mm (500 MPa nominal strength with confinement ratio ωc=0.15. Through casting procedure the necessary provisions defined by International Standards were not applied strictly in order to create construction deficiencies. These deficiencies are quantified geometrically without the use of expensive and expertise non-destructive methods and their effect on the axial load capacity of the concrete columns is calibrated trough a novel and simplified prediction model extracted by an experimental and analytical investigation that included 6 specimens. It is concluded that: a even with suitable repair, load reduction up to 22% is the outcome of the initial construction damage presence, b the lower dispersion is noted for the section damage index proposed, c extended damage alters the failure mode to brittle accompanied with longitudinal bars buckling, d the proposed model presents more than satisfying results to the load capacity prediction of repaired columns.

The proposed 'concordance-statistic for benefit' provided a useful metric when modeling heterogeneous treatment effects.

Science.gov (United States)

van Klaveren, David; Steyerberg, Ewout W; Serruys, Patrick W; Kent, David M

2018-02-01

Clinical prediction models that support treatment decisions are usually evaluated for their ability to predict the risk of an outcome rather than treatment benefit-the difference between outcome risk with vs. without therapy. We aimed to define performance metrics for a model's ability to predict treatment benefit. We analyzed data of the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial and of three recombinant tissue plasminogen activator trials. We assessed alternative prediction models with a conventional risk concordance-statistic (c-statistic) and a novel c-statistic for benefit. We defined observed treatment benefit by the outcomes in pairs of patients matched on predicted benefit but discordant for treatment assignment. The 'c-for-benefit' represents the probability that from two randomly chosen matched patient pairs with unequal observed benefit, the pair with greater observed benefit also has a higher predicted benefit. Compared to a model without treatment interactions, the SYNTAX score II had improved ability to discriminate treatment benefit (c-for-benefit 0.590 vs. 0.552), despite having similar risk discrimination (c-statistic 0.725 vs. 0.719). However, for the simplified stroke-thrombolytic predictive instrument (TPI) vs. the original stroke-TPI, the c-for-benefit (0.584 vs. 0.578) was similar. The proposed methodology has the potential to measure a model's ability to predict treatment benefit not captured with conventional performance metrics. Copyright © 2017 Elsevier Inc. All rights reserved.

A Proposal of B to B Collaboration Process Model based on a Concept of Service and its Application to Energy Saving Service Business

Science.gov (United States)

Zhang, Qi; Kosaka, Michitaka; Shirahada, Kunio; Yabutani, Takashi

This paper proposes a new framework for B to B collaboration process based on a concept of service. Service value, which gives users satisfaction for provided services, depends on the situation, user characteristics, and user objectives in seeking the service. Vargo proposed Service Dominant Logic (SDL), which determines service value according to “value in use”. This concept illustrates the importance of the relationship between the service itself and its situation. This relationship is analogous to electro-magnetic field theory in physics. We developed the concept of service fields to create service value based on an analogy of the electro-magnetic field. By applying this concept to B to B collaboration, a model of service value co-creation in the collaboration can be formulated. Then, the collaboration can be described by 4 steps of KIKI model (Knowledge sharing related to service system, Identification of service field, Knowledge creation for new service idea, Implementation of service idea). As its application to B to B collaboration, the energy saving service business is reported to demonstrate the validity of the proposed collaboration model. This concept can be applied to make a collaboration process effective.

Proposal optimization in nuclear accident emergency decision based on IAHP

International Nuclear Information System (INIS)

Xin Jing

2007-01-01

On the basis of establishing the multi-layer structure of nuclear accident emergency decision, several decision objectives are synthetically analyzed, and an optimization model of decision proposals for nuclear accident emergency based on interval analytic hierarchy process is proposed in the paper. The model makes comparisons among several emergency decision proposals quantified, and the optimum proposal is selected out, which solved the uncertain and fuzzy decision problem of judgments by experts' experiences in nuclear accidents emergency decision. Case study shows that the optimization result is much more reasonable, objective and reliable than subjective judgments, and it could be decision references for nuclear accident emergency. (authors)

Peer review CALMET/CALPUFF dispersion modelling analysis : Proposed Duke Point generation facility Georgia Strait Crossing pipeline

International Nuclear Information System (INIS)

2002-01-01

A peer review of the air quality dispersion modeling analysis for the proposed gas-fired plant at Duke Point in the vicinity of Nanaimo, British Columbia was required, and SENES Consultants Limited (SENES) was commissioned to perform it. British Columbia Hydro had requested that Levelton Engineering Ltd. prepare an air quality impact assessment, and it was submitted to be included in Vancouver Island Generation Project (VIGP) permit application. This permit application was for the Joint Panel Review of the Georgia Strait Crossing Pipeline (GSX) Project and the British Columbia Environmental Assessment Office. The CALMET/CALPUFF Modelling System had been used by Levelton to conduct the air quality dispersion modelling analysis. Copies of the input and output files that had been used for the conduct of the modelling analysis were provided to SENES. The ability for SENES to reproduce the modelling results that had been published in the GSX application represented the first step in the peer review. This was accomplished by running the files received from Levelton into the CALMET/CALPUFF models. A detailed review of the methodology selected by Levelton during the conduct of the dispersion modelling analysis was then initiated by SENES. Some deficiencies were identified by SENES, despite concurrence with the overall conceptual approach adopted by Levelton. The deficiencies concerned meteorological data; startup, partial load and upset conditions; pollutant emissions; health risk assessment; cumulative impact on ambient particulate matter 10 concentrations; and collateral environmental impacts. refs., 2 tabs., 21 figs

Medical Tests and Procedures for Finding and Treating Heart and Blood Vessel Disease

Science.gov (United States)

... Coronary calcium scan Health care providers use electron-beam computed tomography (to-MOG-rah-fee) (EBCT) or ... how the heart performs during activity, such as walking on a moving treadmill. A medication stress test ...

Analyzing “Etka Chain Stores” Strategies and Proposing Optimal Strategies; Using SWOT Model based on Fuzzy Logic

OpenAIRE

Mohammad Aghaei; Amin Asadollahi; Elham Vahedi; Mahdi Pirooz

2013-01-01

To maintain and achieve optimal growth, development and to be more competitive, organizations need a comprehensive and coherent plan compatible with their objectives and goals which is called strategic planning. This research aims to analyse strategically “Etka Chain Stores” and to propose optimal strategies by using SWOT model and based on fuzzy logic. The scope of this research is limited to “Etka Chain stores in Tehran”. As instrumentation, a questioner, consisting of 138 questions, was us...

A proposal for both plasma ion- and electron-temperature diagnostics under simultaneous incidence of particles and x-rays into a semiconductor on the basis of a proposed model for a semiconductor detector response

International Nuclear Information System (INIS)

Numakura, T; Cho, T; Kohagura, J; Hirata, M; Minami, R; Yoshida, M; Nakashima, Y; Tamano, T; Yatsu, K; Miyoshi, S

2003-01-01

A method is proposed for obtaining radial profiles of plasma temperatures of both plasma ion (T i ) and electron (T e ) simultaneously by the use of a semiconductor detector array. The method is based on our developed particle-response model for a semiconductor detector; in particular, the response theory is constructed for giving the applicability in particle energies ranging down to a kiloelectronvolt. Calculated results from our model are in fairly good agreement with experimental data on the detector response of incident particle beams with energies in the range 100 eV to a few kiloelectronvolts. On the basis of the verification of the proposed model, an idea of the use of a developed semiconductor detector array covered with 'reliably unbreakable' ultrathin SiO 2 'dead-layer filters' having various nanometre-order thicknesses is applied for simultaneous T i and T e analyses by using charge-exchange neutral particles and x-rays from plasmas. Radial profiles of T i and T e are obtained in a single plasma discharge alone, and the data reliability is independently cross-checked by a radial scan of a conventional charge-exchange neutral-particle analyser system as well as a 50-channel microchannel plate x-ray diagnostics system in the GAMMA 10 tandem mirror

DAPs: Deep Action Proposals for Action Understanding

KAUST Repository

Escorcia, Victor

2016-09-17

Object proposals have contributed significantly to recent advances in object understanding in images. Inspired by the success of this approach, we introduce Deep Action Proposals (DAPs), an effective and efficient algorithm for generating temporal action proposals from long videos. We show how to take advantage of the vast capacity of deep learning models and memory cells to retrieve from untrimmed videos temporal segments, which are likely to contain actions. A comprehensive evaluation indicates that our approach outperforms previous work on a large scale action benchmark, runs at 134 FPS making it practical for large-scale scenarios, and exhibits an appealing ability to generalize, i.e. to retrieve good quality temporal proposals of actions unseen in training.

What Factors Lead Companies to Adopt Social Media in their processes: Proposal and Test of a Measurement Model

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Jozé Braz de Araújo

2016-01-01

Full Text Available The objective of this study was to understand which factors lead companies to use social media to achieve results. For that, a theoretical model was proposed and tested. Data was collected using a survey of 237 companies. In the analysis we analysis used the structural eq uation modeling technique. The results show that the social media relative advantage and its observability were important factors to social media organizational adoption. We also found that big companies with more formalized organizational structure (OS t end to adopt social media more than small ones with no formal OS. The companies studied showed strong organizational disposition for innovation adoption.

MODEL REQUEST FOR PROPOSALS TO PROVIDE ENERGY AND OTHER ATTRIBUTES FROM AN OFFSHORE WIND POWER PROJECT

Energy Technology Data Exchange (ETDEWEB)

Jeremy Firestone; Dawn Kurtz Crompton

2011-10-22

This document provides a model RFP for new generation. The 'base' RFP is for a single-source offshore wind RFP. Required modifications are noted should a state or utility seek multi-source bids (e.g., all renewables or all sources). The model is premised on proposals meeting threshold requirements (e.g., a MW range of generating capacity and a range in terms of years), RFP issuer preferences (e.g., likelihood of commercial operation by a date certain, price certainty, and reduction in congestion), and evaluation criteria, along with a series of plans (e.g., site, environmental effects, construction, community outreach, interconnection, etc.). The Model RFP places the most weight on project risk (45%), followed by project economics (35%), and environmental and social considerations (20%). However, if a multi-source RFP is put forward, the sponsor would need to either add per-MWh technology-specific, life-cycle climate (CO2), environmental and health impact costs to bid prices under the 'Project Economics' category or it should increase the weight given to the 'Environmental and Social Considerations' category.

Calcium Intervention Ameliorates Experimental Model of Multiple Sclerosis

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Dariush Haghmorad

2014-05-01

Full Text Available Objective: Multiple sclerosis (MS is the most common inflammatory disease of the CNS. Experimental autoimmune encephalomyelitis (EAE is a widely used model for MS. In the present research, our aim was to test the therapeutic efficacy of Calcium (Ca in an experimental model of MS. Methods: In this study the experiment was done on C57BL/6 mice. EAE was induced using 200 μg of the MOG35-55 peptide emulsified in CFA and injected subcutaneously on day 0 over two flank areas. In addition, 250 ng of pertussis toxin was injected on days 0 and 2. In the treatment group, 30 mg/kg Ca was administered intraperitoneally four times at regular 48 hour intervals. The mice were sacrificed 21 days after EAE induction and blood samples were taken from their hearts. The brains of mice were removed for histological analysis and their isolated splenocytes were cultured. Results: Our results showed that treatment with Ca caused a significant reduction in the severity of the EAE. Histological analysis indicated that there was no plaque in brain sections of Ca treated group of mice whereas 4 ± 1 plaques were detected in brain sections of controls. The density of mononuclear infiltration in the CNS of Ca treated mice was lower than in controls. The serum level of Nitric Oxide in the treatment group was lower than in the control group but was not significant. Moreover, the levels of IFN-γ in cell culture supernatant of splenocytes in treated mice were significantly lower than in the control group. Conclusion: The data indicates that Ca intervention can effectively attenuate EAE progression.

A proposed simulation optimization model framework for emergency department problems in public hospital

Science.gov (United States)

Ibrahim, Ireen Munira; Liong, Choong-Yeun; Bakar, Sakhinah Abu; Ahmad, Norazura; Najmuddin, Ahmad Farid

2015-12-01

The Emergency Department (ED) is a very complex system with limited resources to support increase in demand. ED services are considered as good quality if they can meet the patient's expectation. Long waiting times and length of stay is always the main problem faced by the management. The management of ED should give greater emphasis on their capacity of resources in order to increase the quality of services, which conforms to patient satisfaction. This paper is a review of work in progress of a study being conducted in a government hospital in Selangor, Malaysia. This paper proposed a simulation optimization model framework which is used to study ED operations and problems as well as to find an optimal solution to the problems. The integration of simulation and optimization is hoped can assist management in decision making process regarding their resource capacity planning in order to improve current and future ED operations.

Proposing a Capability Perspective on Digital Business Models

OpenAIRE

Bärenfänger, Rieke; Otto, Boris

2015-01-01

Business models comprehensively describe the functioning of businesses in contemporary economic, technological, and societal environments. This paper focuses on the characteristics of digital business models from the perspective of capability research and develops a capability model for digital businesses. Following the design science research (DSR) methodology, multiple evaluation and design iterations were performed. Contributions to the design process came from IS/IT practice and the resea...

Proposed Method for Disaggregation of Secondary Data: The Model for External Reliance of Localities in the Coastal Management Zone (MERLIN-CMZ)

Science.gov (United States)

The Model for External Reliance of Localities In (MERLIN) Coastal Management Zones is a proposed solution to allow scaling of variables to smaller, nested geographies. Utilizing a Principal Components Analysis and data normalization techniques, smaller scale trends are linked to ...

A proposal of ecologic taxes based on thermo-economic performance of heat engine models

International Nuclear Information System (INIS)

Barranco-Jimenez, M. A.; Ramos-Gayosso, I.; Rosales, M. A.; Angulo-Brown, F.

2009-01-01

Within the context of Finite-Time Thermodynamics (FTT) a simplified thermal power plant model (the so-called Novikov engine) is analyzed under economical criteria by means of the concepts of profit function and the costs involved in the performance of the power plant. In this study, two different heat transfer laws are used, the so called Newton's law of cooling and the Dulong-Petit's law of cooling. Two FTT optimization criteria for the performance analysis are used: the maximum power regime (MP) and the so-called ecological criterion. This last criterion leads the engine model towards a mode of performance that appreciably diminishes the engine's wasted energy. In this work, it is shown that the energy-unit price produced under maximum power conditions is cheaper than that produced under maximum ecological (ME) conditions. This was accomplished by using a typical definition of profits function stemming from economics. The MP-regime produces considerably more wasted energy toward the environment, thus the MP energy-unit price is subsidized by nature. Due to this fact, an ecological tax is proposed, which could be a certain function of the price difference between the MP and ME modes of power production. (author)

Sequence Classification: 776671 [

Lifescience Database Archive (English)

Full Text Available ar zinc finger protein, Mog interacting, Ectopic P granules MEP-1, GEX (Gut on EXterior) Interacting protein GEI-2 (97.4 kD) (mep-1) || http://www.ncbi.nlm.nih.gov/protein/25152712 ...

A study on an efficient prediction of welding deformation for T-joint laser welding of sandwich panel PART I : Proposal of a heat source model

Directory of Open Access Journals (Sweden)

Jae Woong Kim

2013-09-01

Full Text Available The use of I-Core sandwich panel has increased in cruise ship deck structure since it can provide similar bending strength with conventional stiffened plate while keeping lighter weight and lower web height. However, due to its thin plate thickness, i.e. about 4~6 mm at most, it is assembled by high power CO2 laser welding to minimize the welding deformation. This research proposes a volumetric heat source model for T-joint of the I-Core sandwich panel and a method to use shell element model for a thermal elasto-plastic analysis to predict welding deformation. This paper, Part I, focuses on the heat source model. A circular cone type heat source model is newly suggested in heat transfer analysis to realize similar melting zone with that observed in experiment. An additional suggestion is made to consider negative defocus, which is commonly applied in T-joint laser welding since it can provide deeper penetration than zero defocus. The proposed heat source is also verified through 3D thermal elasto-plastic analysis to compare welding deformation with experimental results. A parametric study for different welding speeds, defocus values, and welding powers is performed to investigate the effect on the melting zone and welding deformation. In Part II, focuses on the proposed method to employ shell element model to predict welding deformation in thermal elasto-plastic analysis instead of solid element model.

Task-related Functional Connectivity Dynamics in a Block-designed Visual Experiment

Directory of Open Access Journals (Sweden)

Xin eDi

2015-09-01

Full Text Available Studying task modulations of brain connectivity using functional magnetic resonance imaging (fMRI is critical to understand brain functions that support cognitive and affective processes. Existing methods such as psychophysiological interaction (PPI and dynamic causal modelling (DCM usually implicitly assume that the connectivity patterns are stable over a block-designed task with identical stimuli. However, this assumption lacks empirical verification on high-temporal resolution fMRI data with reliable data-driven analysis methods. The present study performed a detailed examination of dynamic changes of functional connectivity (FC in a simple block-designed visual checkerboard experiment with a sub-second sampling rate (TR = 0.645 s by estimating time-varying correlation coefficient (TVCC between BOLD responses of different brain regions. We observed reliable task-related FC changes (i.e., FCs were transiently decreased after task onset and went back to the baseline afterward among several visual regions of the bilateral middle occipital gyrus (MOG and the bilateral fusiform gyrus (FuG. Importantly, only the FCs between higher visual regions (MOG and lower visual regions (FuG exhibited such dynamic patterns. The results suggested that simply assuming a sustained FC during a task block may be insufficient to capture distinct task-related FC changes. The investigation of FC dynamics in tasks could improve our understanding of condition shifts and the coordination between different activated brain regions.

Comparative Effects of Human Neural Stem Cells and Oligodendrocyte Progenitor Cells on the Neurobehavioral Disorders of Experimental Autoimmune Encephalomyelitis Mice

Directory of Open Access Journals (Sweden)

Dae-Kwon Bae

2016-01-01

Full Text Available Since multiple sclerosis (MS is featured with widespread demyelination caused by autoimmune response, we investigated the recovery effects of F3.olig2 progenitors, established by transducing human neural stem cells (F3 NSCs with Olig2 transcription factor, in myelin oligodendrocyte glycoprotein- (MOG- induced experimental autoimmune encephalomyelitis (EAE model mice. Six days after EAE induction, F3 or F3.olig2 cells (1 × 106/mouse were intravenously transplanted. MOG-injected mice displayed severe neurobehavioral deficits which were remarkably attenuated and restored by cell transplantation, in which F3.olig2 cells were superior to its parental F3 cells. Transplanted cells migrated to the injured spinal cord, matured to oligodendrocytes, and produced myelin basic proteins (MBP. The F3.olig2 cells expressed growth and neurotrophic factors including brain-derived neurotrophic factor (BDNF, nerve growth factor (NGF, ciliary neurotrophic factor (CNTF, and leukemia inhibitory factor (LIF. In addition, the transplanted cells markedly attenuated inflammatory cell infiltration, reduced cytokine levels in the spinal cord and lymph nodes, and protected host myelins. The results indicate that F3.olig2 cells restore neurobehavioral symptoms of EAE mice by regulating autoimmune inflammatory responses as well as by stimulating remyelination and that F3.olig2 progenitors could be a candidate for the cell therapy of demyelinating diseases including MS.

Proposal of industrialization process of dredged sediments

Directory of Open Access Journals (Sweden)

Rachid Hadj Sadok

2018-01-01

Full Text Available Our study will focus on life cycle assessment (LCA of dredged sediments in its environment from sediment extraction to waste treatment. This tool is part of an environmental management approach, to compare the environmental loads of the different stages of the life cycle of the same product and to deduce which stage of the scenario is the most polluting in environmental terms. Optimize the modeling of industrialization process of dredged sediments using the SimaPro 8.2.3 software to propose a model that is the most respectful of the environment. We will focus on the environmental impacts; we will try to propose the most environmentally friendly scenario to exploit these dredged sediments in the field of building construction.

Proposed best modeling practices for assessing the effects of ecosystem restoration on fish

Science.gov (United States)

Rose, Kenneth A; Sable, Shaye; DeAngelis, Donald L.; Yurek, Simeon; Trexler, Joel C.; Graf, William L.; Reed, Denise J.

2015-01-01

Large-scale aquatic ecosystem restoration is increasing and is often controversial because of the economic costs involved, with the focus of the controversies gravitating to the modeling of fish responses. We present a scheme for best practices in selecting, implementing, interpreting, and reporting of fish modeling designed to assess the effects of restoration actions on fish populations and aquatic food webs. Previous best practice schemes that tended to be more general are summarized, and they form the foundation for our scheme that is specifically tailored for fish and restoration. We then present a 31-step scheme, with supporting text and narrative for each step, which goes from understanding how the results will be used through post-auditing to ensure the approach is used effectively in subsequent applications. We also describe 13 concepts that need to be considered in parallel to these best practice steps. Examples of these concepts include: life cycles and strategies; variability and uncertainty; nonequilibrium theory; biological, temporal, and spatial scaling; explicit versus implicit representation of processes; and model validation. These concepts are often not considered or not explicitly stated and casual treatment of them leads to mis-communication and mis-understandings, which in turn, often underlie the resulting controversies. We illustrate a subset of these steps, and their associated concepts, using the three case studies of Glen Canyon Dam on the Colorado River, the wetlands of coastal Louisiana, and the Everglades. Use of our proposed scheme will require investment of additional time and effort (and dollars) to be done effectively. We argue that such an investment is well worth it and will more than pay back in the long run in effective and efficient restoration actions and likely avoided controversies and legal proceedings.

Promoter deletions are essential for transformation of lettuce by the T-cyt gene: the phenotypes of transgenic plants

NARCIS (Netherlands)

Curtis, H.E.C.; Jordi, W.; Davelaar, E.; Power, J.B.; Laat, de A.M.M.; Davey, M.R.

1999-01-01

The Agrobacterium T- cyt gene was transferred into lettuce, Latuca sativa‘Saladin’ using a genotype-independent transformation procedure employing a supervirulent Agrobacterium tumefaciens strain carrying the binary vector pMOG23. Kanamycin-resistant shoots were initiated from inoculated explants

A Proposal of Ecologic Taxes Based on Thermo-Economic Performance of Heat Engine Models

Directory of Open Access Journals (Sweden)

Fernando Angulo-Brown

2009-11-01

Full Text Available Within the context of Finite-Time Thermodynamics (FTT a simplified thermal power plant model (the so-called Novikov engine is analyzed under economical criteria by means of the concepts of profit function and the costs involved in the performance of the power plant. In this study, two different heat transfer laws are used, the so called Newton’s law of cooling and the Dulong-Petit’s law of cooling. Two FTT optimization criteria for the performance analysis are used: the maximum power regime (MP and the so-called ecological criterion. This last criterion leads the engine model towards a mode of performance that appreciably diminishes the engine’s wasted energy. In this work, it is shown that the energy-unit price produced under maximum power conditions is cheaper than that produced under maximum ecological (ME conditions. This was accomplished by using a typical definition of profits function stemming from economics. The MP-regime produces considerably more wasted energy toward the environment, thus the MP energy-unit price is subsidized by nature. Due to this fact, an ecological tax is proposed, which could be a certain function of the price difference between the MP and ME modes of power production.

A proposal of ecologic taxes based on thermo-economic performance of heat engine models

Energy Technology Data Exchange (ETDEWEB)

Barranco-Jimenez, M. A. [Departamento de Ciencias Basicas, Escuela Superior de Computo del IPN, Av. Miguel Bernal Esq. Juan de Dios Batiz U.P. Zacatenco CP 07738, D.F. (Mexico); Ramos-Gayosso, I. [Unidad de Administracion de Riesgos, Banco de Mexico, 5 de Mayo, Centro, D.F. (Mexico); Rosales, M. A. [Departamento de Fisica y Matematicas, Universidad de las Americas, Puebla Exhacienda Sta. Catarina Martir, Cholula 72820, Puebla (Mexico); Angulo-Brown, F. [Departamento de Fisica, Escuela Superior de Fisica y Matematicas del IPN, Edif. 9 U.P. Zacatenco CP 07738, D.F. (Mexico)

2009-07-01

Within the context of Finite-Time Thermodynamics (FTT) a simplified thermal power plant model (the so-called Novikov engine) is analyzed under economical criteria by means of the concepts of profit function and the costs involved in the performance of the power plant. In this study, two different heat transfer laws are used, the so called Newton's law of cooling and the Dulong-Petit's law of cooling. Two FTT optimization criteria for the performance analysis are used: the maximum power regime (MP) and the so-called ecological criterion. This last criterion leads the engine model towards a mode of performance that appreciably diminishes the engine's wasted energy. In this work, it is shown that the energy-unit price produced under maximum power conditions is cheaper than that produced under maximum ecological (ME) conditions. This was accomplished by using a typical definition of profits function stemming from economics. The MP-regime produces considerably more wasted energy toward the environment, thus the MP energy-unit price is subsidized by nature. Due to this fact, an ecological tax is proposed, which could be a certain function of the price difference between the MP and ME modes of power production. (author)

Modeling commuter preferences for the proposed bus rapid transit in Dar-es-Salaam

NARCIS (Netherlands)

Nkurunziza, A.; Zuidgeest, M.H.P.; Brussel, M.J.G.; van Maarseveen, M.F.A.M.

2012-01-01

The paper analyzes individual commuter preferences towards the proposed bus rapid transit (BRT) system in Dar-es-Salaam, Tanzania. The objective of the survey was to identify how commuters perceive and value the proposed BRT service quality attributes. A stated preference survey of potential users

A proposed model for construction project management ...

African Journals Online (AJOL)

Log in or Register to get access to full text downloads. ... (decision-making, problem-solving, listening, verbal competency, motivation, persuasion, ... Keywords: Communication skills and leadership model, construction project management, ...

A proposed model for construction project management ...

African Journals Online (AJOL)

Keywords: Communication skills and leadership model, construction project ..... help a manager handle stress and break tension (Gido & Clements,. 2012: 331; Harrin .... production and management of projects, the higher the demand for.

Evaluation of the existing triple point path models with new experimental data: proposal of an original empirical formulation

Science.gov (United States)

Boutillier, J.; Ehrhardt, L.; De Mezzo, S.; Deck, C.; Magnan, P.; Naz, P.; Willinger, R.

2018-03-01

With the increasing use of improvised explosive devices (IEDs), the need for better mitigation, either for building integrity or for personal security, increases in importance. Before focusing on the interaction of the shock wave with a target and the potential associated damage, knowledge must be acquired regarding the nature of the blast threat, i.e., the pressure-time history. This requirement motivates gaining further insight into the triple point (TP) path, in order to know precisely which regime the target will encounter (simple reflection or Mach reflection). Within this context, the purpose of this study is to evaluate three existing TP path empirical models, which in turn are used in other empirical models for the determination of the pressure profile. These three TP models are the empirical function of Kinney, the Unified Facilities Criteria (UFC) curves, and the model of the Natural Resources Defense Council (NRDC). As discrepancies are observed between these models, new experimental data were obtained to test their reliability and a new promising formulation is proposed for scaled heights of burst ranging from 24.6-172.9 cm/kg^{1/3}.

A Proposed Curriculum Model for Geriatric Optometry.

Science.gov (United States)

Rosenbloom, Albert A.

1985-01-01

A model for a geriatric optometry curriculum that defines key content areas and addresses the values essential for effective practice and basic therapeutic modalities used in treatment regimens with older adults is outlined. (MSE)

Proposal of a social alliance success model from a relationship marketing perspective: A meta-analytical study of the theoretical foundations

Directory of Open Access Journals (Sweden)

María Jesús Barroso-Méndez

2015-07-01

Full Text Available Partnerships between businesses and non-governmental organizations (NGOs have become widely adopted mechanisms for collaboration in addressing complex social issues, the aim being to take advantage of the two types of organizational rationale to generate mutual value. Many such alliances have proved to be unsuccessful, however. To assist managers improve the likelihood of success of their collaborative relationships, the authors propose a success model of business-NGO partnering processes based on Relationship Marketing Theory. They also analyse the theoretical bases of the model's hypotheses through a meta-analytical study of the existing literature.

Analogy, an Alternative Model.
 Critics to the standard model of analogical problems solving and proposals for an alternative one

Directory of Open Access Journals (Sweden)

Ricardo A. Minervino

2016-02-01

Full Text Available The authors made an extension of Hofstadter‘s criticisms against the standard approach in analogical thinking represented by the structure-mapping theory of Gentner and the multiconstraint theory of Holyoak and Thagard. Based on this extension, they proposed a non-serial model of analogical problem solving. Against the standard approach, the model postulates that: (a people detect and evaluate differences between mapped elements before the subprocess of inference generation and consider them in order to control it, and (b properties of an element that explain why the element could fill a certain role in the base problem resolution (PERs play a crucial role in these detection and evaluation operations, and also in post-inferences subprocesses. An experiment showed that: (a people detect and evaluate the relevance of differences between mapped elements before inference generation, (b that they inhibit the generation of literal inferences when they face relevant differences, and (c that they stop the subprocess when they recognize insuperable ones. The results also showed that base PERs are reactivated at different moments of analogical transfer. The data obtained are incompatible with the standard theories of analogical thinking, which treat inference generation as a syntactic mechanism and exclude contextual semantic analysis from the study of analogy. 

Sports Management for Sports Massification Planned and Executed by Social Organizations. Critics to Models, Experiences and Proposal Methodological Accompaniment

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Lorenza Antonia Reyes de Duran

2016-08-01

Full Text Available The proposal analysis, interpretation, disassembly, self-criticism and guidance is born and comes from work experience planned mass sports and social organizations opposed-not in the conventional sense comparative-private business models and sport, state and management. The contribution made by the sports management experience from positions of power, either state or business are undeniable and its impact is difficult to express in numbers for its humanistic value, which is incalculable. However, it is urgent to emphasize the products and results achieved by some social organizations related to sport; as are the reference cases in Higuerón and the municipality Independence of Yaracuy state. From a dialectical analysis of reality, we try to understand the complex system that involves high-level sports management and performance, we introduce in the praxical notions of sporting activity and associated approach applied to social and community work. As opening and closing action research processes, we will make a proposal to accompany sports management concerning overcrowding by and from social organizations. This proposal is constructed from an innovative, flexible, open, inclusive and social, community and organizational curriculum relevance.

Black Hole on a Chip: Proposal for a Physical Realization of the Sachdev-Ye-Kitaev model in a Solid-State System

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D. I. Pikulin

2017-07-01

Full Text Available A system of Majorana zero modes with random infinite-range interactions—the Sachdev-Ye-Kitaev (SYK model—is thought to exhibit an intriguing relation to the horizons of extremal black holes in two-dimensional anti–de Sitter space. This connection provides a rare example of holographic duality between a solvable quantum-mechanical model and dilaton gravity. Here, we propose a physical realization of the SYK model in a solid-state system. The proposed setup employs the Fu-Kane superconductor realized at the interface between a three-dimensional topological insulator and an ordinary superconductor. The requisite N Majorana zero modes are bound to a nanoscale hole fabricated in the superconductor that is threaded by N quanta of magnetic flux. We show that when the system is tuned to the surface neutrality point (i.e., chemical potential coincident with the Dirac point of the topological insulator surface state and the hole has sufficiently irregular shape, the Majorana zero modes are described by the SYK Hamiltonian. We perform extensive numerical simulations to demonstrate that the system indeed exhibits physical properties expected of the SYK model, including thermodynamic quantities and two-point as well as four-point correlators, and discuss ways in which these can be observed experimentally.

Algorithms to analyze the quality test parameter values of seafood in the proposed ontology based seafood quality analyzer and miner (ONTO SQAM model

Directory of Open Access Journals (Sweden)

Vinu Sherimon

2017-07-01

Full Text Available Ensuring the quality of food, particularly seafood has increasingly become an important issue nowadays. Quality Management Systems empower any organization to identify, measure, control and improve the quality of the products manufactured that will eventually lead to improved business performance. With the advent of new technologies, now intelligent systems are being developed. To ensure the quality of seafood, an ontology based seafood quality analyzer and miner (ONTO SQAM model is proposed. The knowledge is represented using ontology. The domain concepts are defined using ontology. This paper presents the initial part of the proposed model – the analysis of quality test parameter values. Two algorithms are proposed to do the analysis – Comparison Algorithm and Data Store Updater algorithm. The algorithms ensure that the values of various quality tests are in the acceptable range. The real data sets taken from different seafood companies in Kerala, India, and validated by the Marine Product Export Development Authority of India (MPEDA are used for the experiments. The performance of the algorithms is evaluated using standard performance metrics such as precision, recall, and accuracy. The results obtained show that all the three measures achieved good results.

Proposed Model for Translational Research at a Teaching-Intensive College of Pharmacy.

Science.gov (United States)

Ulrich, Erin; Grady, Sarah; Vonderhaar, Jacqueline; Ruplin, Andrew

2017-08-08

Many American colleges of pharmacy are small, private, teaching institutions. Faculty are required to maintain a research agenda, although the publication quota is less compared with their publicly funded college of pharmacy peers. Faculty at these smaller schools conduct research with very little internal or external funding. This tends to lead to smaller, less impactful research findings. Translational research is becoming popular for research faculty as it bridges theory to practice. The Knowledge-to-Action (KTA) framework presents the steps to conduct translational research. To apply and determine if the KTA framework would be able to produce practice-impactful research at an institution that does not depend on grant funding as part of faculty research agendas. An interdisciplinary team was formed with providers at the clinical faculty's practice site. As the team moved through the KTA steps, authors documented the roles of each team member. It was clear that many different types of teams were formed throughout the KTA process. These teams were then categorized according to the Interdisciplinary Teamwork System. The final result is a proposed model of types of teams and required member roles that are necessary within each KTA step for faculty to conduct practice-impactful research at a small, private, teaching institution without substantial grant funding awards. Applying the KTA framework, two impactful original research manuscripts were developed over two academic years. Furthermore, the practitioners at the clinical faculty member's site were very pleased with the ease of conducting research, as they were never required to take a lead role. In addition, both faculty members alternated lead and support role allowing for a decreased burden of workload while producing theory-driven research. The KTA framework can create a model for translational research and may be particularly beneficial to small teaching institutions to conduct impactful research. Copyright �

Sports Management for Sports Massification Planned and Executed by Social Organizations. Critics to Models, Experiences and Proposal Methodological Accompaniment

OpenAIRE

Lorenza Antonia Reyes de Duran

2016-01-01

The proposal analysis, interpretation, disassembly, self-criticism and guidance is born and comes from work experience planned mass sports and social organizations opposed-not in the conventional sense comparative-private business models and sport, state and management. The contribution made by the sports management experience from positions of power, either state or business are undeniable and its impact is difficult to express in numbers for its humanistic value, which is incalculable. Howe...

An analysis of a three-factor model proposed by the Danish Society of Actuaries for forecasting and risk analysis

OpenAIRE

Jørgensen, Peter Løchte; Slipsager, Søren Kærgaard

2016-01-01

This paper provides the explicit solution to the three-factor diffusion model recently proposed by the Danish Society of Actuaries to the Danish industry of life insurance and pensions. The solution is obtained by use of the known general solution to multidimensional linear stochastic differential equation systems. With offset in the explicit solution, we establish the conditional distribution of the future state variables which allows for exact simulation. Using exact simulation, we illustra...

Comparison of two analytical models of blanking and proposal of a new model

NARCIS (Netherlands)

Klingenberg, W; Singh, UP

With the development of accurate Finite Element models of the punching/blanking process by the present authors and other researchers, important possibilities emerged to model and analyse the process in a research environment. However, Finite Element models are less well suited for use in a

Exacerbation of experimental autoimmune encephalomyelitis in prion protein (PrPc-null mice: evidence for a critical role of the central nervous system

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Gourdain Pauline

2012-01-01

Full Text Available Abstract Background The cellular prion protein (PrPc is a host-encoded glycoprotein whose transconformation into PrP scrapie (PrPSc initiates prion diseases. The role of PrPc in health is still obscure, but many candidate functions have been attributed to the protein, both in the immune and the nervous systems. Recent data show that experimental autoimmune encephalomyelitis (EAE is worsened in mice lacking PrPc. Disease exacerbation has been attributed to T cells that would differentiate into more aggressive effectors when deprived of PrPc. However, alternative interpretations such as reduced resistance of neurons to autoimmune insult and exacerbated gliosis leading to neuronal deficits were not considered. Method To better discriminate the contribution of immune cells versus neural cells, reciprocal bone marrow chimeras with differential expression of PrPc in the lymphoid or in the central nervous system (CNS were generated. Mice were subsequently challenged with MOG35-55 peptide and clinical disease as well as histopathology were compared in both groups. Furthermore, to test directly the T cell hypothesis, we compared the encephalitogenicity of adoptively transferred PrPc-deficient versus PrPc-sufficient, anti-MOG T cells. Results First, EAE exacerbation in PrPc-deficient mice was confirmed. Irradiation exacerbated EAE in all the chimeras and controls, but disease was more severe in mice with a PrPc-deleted CNS and a normal immune system than in the reciprocal construction. Moreover, there was no indication that anti-MOG responses were different in PrPc-sufficient and PrPc-deficient mice. Paradoxically, PrPc-deficient anti-MOG 2D2 T cells were less pathogenic than PrPc-expressing 2D2 T cells. Conclusions In view of the present data, it can be concluded that the origin of EAE exacerbation in PrPc-ablated mice resides in the absence of the prion protein in the CNS. Furthermore, the absence of PrPc on both neural and immune cells does not

BLAM (Benthic Light Availability Model): A Proposed Model of Hydrogeomorphic Controls on Light in Rivers

Science.gov (United States)

Julian, J. P.; Doyle, M. W.; Stanley, E. H.

2006-12-01

Light is vital to the dynamics of aquatic ecosystems. It drives photosynthesis and photochemical reactions, affects thermal structure, and influences behavior of aquatic biota. Despite the fundamental role of light to riverine ecosystems, light studies in rivers have been mostly neglected because i) boundary conditions (e.g., banks, riparian vegetation) make ambient light measurements difficult, and ii) the optical water quality of rivers is highly variable and difficult to characterize. We propose a benthic light availability model (BLAM) that predicts the percent of incoming photosynthetically active radiation (PAR) available at the river bed. BLAM was developed by quantifying light attenuation of the five hydrogeomorphic controls that dictate riverine light availability: topography, riparian vegetation, channel geometry, optical water quality, and water depth. BLAM was calibrated using hydrogeomorphic data and light measurements from two rivers: Deep River - a 5th-order, turbid river in central North Carolina, and Big Spring Creek - a 2nd-order, optically clear stream in central Wisconsin. We used a series of four PAR sensors to measure i) above-canopy PAR, ii) PAR above water surface, iii) PAR below water surface, and iv) PAR on stream bed. These measurements were used to develop empirical light attenuation coefficients, which were then used in combination with optical water quality measurements, shading analyses, channel surveys, and flow records to quantify the spatial and temporal variability in riverine light availability. Finally, we apply BLAM to the Baraboo River - a 6th-order, 120-mile, unimpounded river in central Wisconsin - in order to characterize light availability along the river continuum (from headwaters to mouth).

An auxiliary graph based dynamic traffic grooming algorithm in spatial division multiplexing enabled elastic optical networks with multi-core fibers

Science.gov (United States)

Zhao, Yongli; Tian, Rui; Yu, Xiaosong; Zhang, Jiawei; Zhang, Jie

2017-03-01

A proper traffic grooming strategy in dynamic optical networks can improve the utilization of bandwidth resources. An auxiliary graph (AG) is designed to solve the traffic grooming problem under a dynamic traffic scenario in spatial division multiplexing enabled elastic optical networks (SDM-EON) with multi-core fibers. Five traffic grooming policies achieved by adjusting the edge weights of an AG are proposed and evaluated through simulation: maximal electrical grooming (MEG), maximal optical grooming (MOG), maximal SDM grooming (MSG), minimize virtual hops (MVH), and minimize physical hops (MPH). Numeric results show that each traffic grooming policy has its own features. Among different traffic grooming policies, an MPH policy can achieve the lowest bandwidth blocking ratio, MEG can save the most transponders, and MSG can obtain the fewest cores for each request.

Futility Disputes: A Review of the Literature and Proposed Model for Dispute Navigation Through Trust Building.

Science.gov (United States)

Leland, Brian D; Torke, Alexia M; Wocial, Lucia D; Helft, Paul R

2017-10-01

Futility disputes in the intensive care unit setting have received significant attention in the literature over the past several years. Although the idea of improving communication in an attempt to resolve these challenging situations has been regularly discussed, the concept and role of trust building as the means by which communication improves and disputes are best navigated is largely absent. We take this opportunity to review the current literature on futility disputes and argue the important role of broken trust in these encounters, highlighting current evidence establishing the necessity and utility of trust in both medical decision-making and effective communication. Finally, we propose a futility dispute navigation model built upon improved communication through trust building.

On the universality of MOG weak field approximation at galaxy cluster scale

Directory of Open Access Journals (Sweden)

Ivan De Martino

2017-07-01

Full Text Available In its weak field limit, Scalar-tensor-vector gravity theory introduces a Yukawa-correction to the gravitational potential. Such a correction depends on the two parameters, α which accounts for the modification of the gravitational constant, and μ⁎−1 which represents the scale length on which the scalar field propagates. These parameters were found to be universal when the modified gravitational potential was used to fit the galaxy rotation curves and the mass profiles of galaxy clusters, both without Dark Matter. We test the universality of these parameters using the temperature anisotropies due to the thermal Sunyaev–Zeldovich effect. In our model the intra-cluster gas is in hydrostatic equilibrium within the modified gravitational potential well and it is described by a polytropic equation of state. We predict the thermal Sunyaev–Zeldovich temperature anisotropies produced by Coma cluster, and we compare them with those obtained using the Planck 2013 Nominal maps. In our analysis, we find α and the scale length, respectively, to be consistent and to depart from their universal values. Our analysis points out that the assumption of the universality of the Yukawa-correction to the gravitational potential is ruled out at more than 3.5σ at galaxy clusters scale, while demonstrating that such a theory of gravity is capable to fit the cluster profile if the scale dependence of the gravitational potential is restored.

Hybrid cluster state proposal for a quantum game

International Nuclear Information System (INIS)

Paternostro, M; Tame, M S; Kim, M S

2005-01-01

We propose an experimental implementation of a quantum game algorithm in a hybrid scheme combining the quantum circuit approach and the cluster state model. An economical cluster configuration is suggested to embody a quantum version of the Prisoners' Dilemma. Our proposal is shown to be within the experimental state of the art and can be realized with existing technology.The effects of relevant experimental imperfections are also carefully examined

Incorporating the user perspective into a proposed model for assessing success of SHS implementations

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Hans Holtorf

2015-10-01

Full Text Available Modern energy can contribute to development in multiple ways while approximately 20% of world's populations do not yet have access to electricity. Solar Home Systems (SHSs consists of a PV module, a charge controller and a battery supply in the range of 100 Wh/d in Sunbelt countries. The question addressed in this paper is how SHS users approach success of their systems and how these user's views can be integrated in to an existing model of success. Information was obtained on the user's approach to their SHSs by participatory observation, interviews with users and by self-observation undertaken by the lead author while residing under SHS electricity supply conditions. It was found that success of SHSs from the users' point of view is related to the ability of these systems to reduce the burdens of supplying energy services to homesteads. SHSs can alleviate some energy supply burdens, and they can improve living conditions by enabling communication on multiple levels and by addressing convenience and safety concerns. However, SHSs do not contribute to the energy services which are indispensable for survival, nor to the thermal energy services required and desired in dwellings of Sunbelt countries. The elements of three of the four components of our previously proposed model of success have been verified and found to be appropriate, namely the user's self-set goals, their importance and SHSs' success factors. The locally appropriate, and scientifically satisfactory, measurement of the level of achievement of self-set goals, the fourth component of our model of success, remains an interesting area for future research.

Multiscale Model Simulations of Temperature and Relative Humidity for the License Application of the Proposed Yucca Mountain Repository

Science.gov (United States)

Buscheck, T.; Glascoe, L.; Sun, Y.; Gansemer, J.; Lee, K.

2003-12-01

For the proposed Yucca Mountain geologic repository for high-level nuclear waste, the planned method of disposal involves the emplacement of cylindrical packages containing the waste inside horizontal tunnels, called emplacement drifts, bored several hundred meters below the ground surface. The emplacement drifts reside in highly fractured, partially saturated volcanic tuff. An important phenomenological consideration for the licensing of the proposed repository at Yucca Mountain is the generation of decay heat by the emplaced waste and the consequences of this decay heat. Changes in temperature will affect the hydrologic and chemical environment at Yucca Mountain. A thermohydrologic-modeling tool is necessary to support the performance assessment of the Engineered Barrier System (EBS) of the proposed repository. This modeling tool must simultaneously account for processes occurring at a scale of a few tens of centimeters around individual waste packages, for processes occurring around the emplacement drifts themselves, and for processes occurring at the multi-kilometer scale of the mountain. Additionally, many other features must be considered including non-isothermal, multiphase-flow in fractured porous rock of variable liquid-phase saturation and thermal radiation and convection in open cavities. The Multiscale Thermohydrologic Model (MSTHM) calculates the following thermohydrologic (TH) variables: temperature, relative humidity, liquid-phase saturation, evaporation rate, air-mass fraction, gas-phase pressure, capillary pressure, and liquid- and gas-phase fluxes. The TH variables are determined as a function of position along each of the emplacement drifts in the repository and as a function of waste-package (WP) type. These variables are determined at various generic locations within the emplacement drifts, including the waste package and drip-shield surfaces and in the invert; they are also determined at various generic locations in the adjoining host rock

Nuclear Power Plant Life Management - Challenges and Proposal for a Unified Model Integrating Safety and Economics

International Nuclear Information System (INIS)

Contri, Paolo; Elsing, Bernhard

2011-01-01

In recent years many electric utilities and nuclear power plants adopted policies for improved coordination of both safety and non-safety programs, called plant life management (PLIM), also in view on plant life extension programs, but mainly for an optimisation of operating costs. The implementation of PLIM programs has followed many different approaches, being intrinsically dependent on the national regulatory framework and technical traditions. In Countries with some experience, the PLIM program proved very convenient, especially when coupled with Maintenance, Surveillance an Inspection (MS and I) optimization: average savings are reported in the range of 20-30% of total (maintenance) costs. A unified European model for PLIM was developed at the JRC-Institute for Energy with the support of a network of stakeholders (SENUF), and validated at some EU nuclear plants. This paper provides a summary of the model features, the result of its validation at some plants and summarises the perceived scientific/technological challenges on which JRC proposes to focus, based upon its competencies and skills, having in mind both the European and world-wide context and its potential evolution. (author)

Search for Hidden Particles: a new experiment proposal

Science.gov (United States)

De Lellis, G.

2015-08-01

Searches for new physics with accelerators are being performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. We propose a new experiment meant to search for very weakly coupled particles in the few GeV mass domain. The existence of such particles, foreseen in different models beyond the Standard Model, is largely unexplored from the experimental point of view. A beam dump facility, built at CERN in the north area, using 400 GeV protons is a copious factory of charmed hadrons and it could be used to probe the existence of such particles. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. In particular, tau anti-neutrinos have not been observed so far. We therefore propose an experiment to search for hidden particles and study tau neutrino physics at the same time.

A proposal for a determination method of element division on an analytical model for finite element elastic waves propagation analysis

International Nuclear Information System (INIS)

Ishida, Hitoshi; Meshii, Toshiyuki

2010-01-01

This study proposes an element size selection method named the 'Impact-Meshing (IM) method' for a finite element waves propagation analysis model, which is characterized by (1) determination of element division of the model with strain energy in the whole model, (2) static analysis (dynamic analysis in a single time step) with boundary conditions which gives a maximum change of displacement in the time increment and inertial (impact) force caused by the displacement change. In this paper, an example of application of the IM method to 3D ultrasonic wave propagation problem in an elastic solid is described. These examples showed an analysis result with a model determined by the IM method was convergence and calculation time for determination of element subdivision was reduced to about 1/6 by the IM Method which did not need determination of element subdivision by a dynamic transient analysis with 100 time steps. (author)

Spatially Resolved MR-Compatible Doppler Ultrasound: Proof of Concept for Triggering of Diagnostic Quality Cardiovascular MRI for Function and Flow Quantification at 3T.

Science.gov (United States)

Crowe, Lindsey Alexandra; Manasseh, Gibran; Chmielewski, Aneta; Hachulla, Anne-Lise; Speicher, Daniel; Greiser, Andreas; Muller, Hajo; de Perrot, Thomas; Vallee, Jean-Paul; Salomir, Rares

2018-02-01

We demonstrate the use of a magnetic-resonance (MR)-compatible ultrasound (US) imaging probe using spatially resolved Doppler for diagnostic quality cardiovascular MR imaging (MRI) as an initial step toward hybrid US/MR fetal imaging. A newly developed technology for a dedicated MR-compatible phased array ultrasound-imaging probe acquired pulsed color Doppler carotid images, which were converted in near-real time to a trigger signal for cardiac cine and flow quantification MRI. Ultrasound and MR data acquired simultaneously were interference free. Conventional electrocardiogram (ECG) and the proposed spatially resolved Doppler triggering were compared in 10 healthy volunteers. A synthetic "false-triggered" image was retrospectively processed using metric optimized gating (MOG). Images were scored by expert readers, and sharpness, cardiac function and aortic flow were quantified. Four-dimensional (4-D) flow (two volunteers) showed feasibility of Doppler triggering over a long acquisition time. Imaging modalities were compatible. US probe positioning was stable and comfortable. Image quality scores and quantified sharpness were statistically equal for Doppler- and ECG-triggering (p ). ECG-, Doppler-triggered, and MOG ejection fractions were equivalent (p ), with false-triggered values significantly lower (p 0.05). 4-D flow quantification gave consistent results between ECG and Doppler triggering. We report interference-free pulsed color Doppler ultrasound during MR data acquisition. Cardiovascular MRI of diagnostic quality was successfully obtained with pulsed color Doppler triggering. The hardware platform could further enable advanced free-breathing cardiac imaging. Doppler ultrasound triggering is applicable where ECG is compromised due to pathology or interference at higher magnetic fields, and where direct ECG is impossible, i.e., fetal imaging.

The role of tourism public-private partnerships in regional development: a conceptual model proposal

Directory of Open Access Journals (Sweden)

Mário Franco

Full Text Available Tourism is characterized as being a sector that stands out as one of the business activities with the greatest potential for worldwide expansion, and as an engine for economic growth. If at the national level, the appeal of tourism is significant, on the local level this sector presents itself as an essential tool in regional development, as a means to avoid regional desertification and stagnation, stimulating the potential of more undeveloped regions. In such a competitive sector as tourism, companies should develop synergies and achieve competitive advantage. In this context, public-private partnerships play an important role in regional development. The aim of this paper is to present a theoretical context that combines different concepts and elements to explain and understand the public-private partnership phenomenon in tourism. A conceptual model of the role of public-private partnerships will be proposed in order to contribute to successful regional development.

DAPs: Deep Action Proposals for Action Understanding

KAUST Repository

Escorcia, Victor; Caba Heilbron, Fabian; Niebles, Juan Carlos; Ghanem, Bernard

2016-01-01

action proposals from long videos. We show how to take advantage of the vast capacity of deep learning models and memory cells to retrieve from untrimmed videos temporal segments, which are likely to contain actions. A comprehensive evaluation indicates

DNA Methylation at the Neonatal State and at the Time of Diagnosis: Preliminary Support for an Association with the Estrogen Receptor 1, Gamma-Aminobutyric Acid B Receptor 1, and Myelin Oligodendrocyte Glycoprotein in Female Adolescent Patients with OCD.

Science.gov (United States)

Nissen, Judith Becker; Hansen, Christine Søholm; Starnawska, Anna; Mattheisen, Manuel; Børglum, Anders Dupont; Buttenschøn, Henriette Nørmølle; Hollegaard, Mads

2016-01-01

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder. Non-genetic factors and their interaction with genes have attracted increasing attention. Epigenetics is regarded an important interface between environmental signals and activation/repression of genomic responses. Epigenetic mechanisms have not previously been examined in OCD in children and adolescents. The aim of the present study was to examine the DNA methylation profile of selected genes in blood spots from neonates later diagnosed with OCD and in the same children/adolescents at the time of diagnosis compared with age- and sex-matched controls. Furthermore, we wanted to characterize the association of the differential methylation profiles with the severity of OCD and treatment outcome. Dried and new blood spot samples were obtained from 21 female children/adolescents with verified OCD and 12 female controls. The differential methylation was analyzed using a linear model and the correlation with the severity of OCD and treatment outcome was analyzed using the Pearson correlation. We evaluated selected Illumina Infinium HumanMethylation450 BeadChip probes within and up to 100,000 bp up- and downstream of 14 genes previously associated with OCD (SLC1A1, SLC25A12, GABBR1, GAD1, DLGAP1, MOG, BDNF, OLIG2, NTRK2 and 3, ESR1, SL6A4, TPH2, and COMT). The study found no significantly differential methylation. However, preliminary support for a difference was found for the gamma-aminobutyric acid (GABA) B receptor 1 (cg10234998, cg17099072) in blood samples at birth and for the estrogen receptor 1 (ESR1) (cg10939667), the myelin oligodendrocyte glycoprotein (MOG) (cg16650906), and the brain-derived neurotrophic factor (BDNF) (cg14080521) in blood samples at the time of diagnosis. Preliminary support for an association was observed between the methylation profiles of GABBR1 and MOG and baseline severity, treatment effect, and responder status; and between the methylation profile of ESR1 and baseline

Prevalence of multiple sclerosis in Verona, Italy: an epidemiological and genetic study.

Science.gov (United States)

Gajofatto, A; Stefani, A; Turatti, M; Bianchi, M R; Lira, M G; Moretto, G; Salviati, A; Benedetti, M D

2013-04-01

Recent multiple sclerosis (MS) prevalence studies classify Italy as a high-risk area without intra-regional latitude effect. To determine MS prevalence in Verona, Italy, and frequency of myelin oligodendrocyte glycoprotein (MOG) gene G511C polymorphism and HLA-DRB1*15 locus in a sample of cases and healthy controls. The study area population on the prevalence date (31 December 2001) was 253208 (133508 women, 119700 men). Multiple case sources were examined. Patients fulfilling McDonald's criteria (2001) were included. Crude, age- and sex-specific prevalence rates were computed. MOG G511C polymorphism and HLA-DRB1*15 were determined by standard methods. We identified 270 cases of MS yielding a crude prevalence rate of 106.6/100000 (95% CI: 94-120). Prevalence was higher in women (140.8/100000) than in men (68.5/100000). The age-adjusted prevalence rate standardized to the European population was 96.0/100000. MOG G511C polymorphism did not differ between cases and controls. HLA-DRB1*15 frequency was 58/155 (37%) in cases and 24/157 (15%) in controls (P<0.001). There was no HLA-DRB1*15 influence on susceptibility to other autoimmune disorders. The high MS prevalence in Verona confirms Italy as a high-risk area with a homogenous distribution across the country. HLA-DRB1*15 is a relevant MS susceptibility locus in the Italian population, possibly with little influence on the occurrence of concomitant autoimmune disorders. © 2012 The Author(s) European Journal of Neurology © 2012 EFNS.

Product/Service-Systems: Proposal for models and terminology

DEFF Research Database (Denmark)

Matzen, Detlef; Tan, Adrian; Andreasen, Mogens Myrup

2005-01-01

very blurred and ill defined. This paper will try to identify the fundamental characteristics of PSS and propose a system of concepts that can be used to describe and discuss the phenomenon, for the purpose of developing new PSS solutions. Coming from a tradition of product development research......Over recent years a growing number of studies and research programmes have been conducted on the issue of product/service-systems (PSS) [1, 2] and results have been presented at this row of symposia [3, 4]. These studies usually analyse the potential of integrated solutions to reduce...... the environmental impacts of human consumption activity or optimise a company’s ability to cope with the influences arising from the emerging globalisation of economic and business activities. Since there has not been worked on a coherent terminology for the terms and concepts used in PSS research, the area remains...

Engaging Struggling Adolescent Readers through Situational Interest: A Model Proposing the Relationships among Extrinsic Motivation, Oral Reading Proficiency, Comprehension, and Academic Achievement

Science.gov (United States)

Paige, David D.

2011-01-01

Reading ability and motivation among adolescents across the country continues to be problematic, as only slightly more than one-third read at a proficient level (Grigg, Donahue, & Dion, 2007; Unrau & Schlackman, 2006). Hidi and Renninger (2006) have proposed a four-phase model of situational interest that suggests how activities involving…

Automating Construction of Machine Learning Models With Clinical Big Data: Proposal Rationale and Methods.

Science.gov (United States)

Luo, Gang; Stone, Bryan L; Johnson, Michael D; Tarczy-Hornoch, Peter; Wilcox, Adam B; Mooney, Sean D; Sheng, Xiaoming; Haug, Peter J; Nkoy, Flory L

2017-08-29

To improve health outcomes and cut health care costs, we often need to conduct prediction/classification using large clinical datasets (aka, clinical big data), for example, to identify high-risk patients for preventive interventions. Machine learning has been proposed as a key technology for doing this. Machine learning has won most data science competitions and could support many clinical activities, yet only 15% of hospitals use it for even limited purposes. Despite familiarity with data, health care researchers often lack machine learning expertise to directly use clinical big data, creating a hurdle in realizing value from their data. Health care researchers can work with data scientists with deep machine learning knowledge, but it takes time and effort for both parties to communicate effectively. Facing a shortage in the United States of data scientists and hiring competition from companies with deep pockets, health care systems have difficulty recruiting data scientists. Building and generalizing a machine learning model often requires hundreds to thousands of manual iterations by data scientists to select the following: (1) hyper-parameter values and complex algorithms that greatly affect model accuracy and (2) operators and periods for temporally aggregating clinical attributes (eg, whether a patient's weight kept rising in the past year). This process becomes infeasible with limited budgets. This study's goal is to enable health care researchers to directly use clinical big data, make machine learning feasible with limited budgets and data scientist resources, and realize value from data. This study will allow us to achieve the following: (1) finish developing the new software, Automated Machine Learning (Auto-ML), to automate model selection for machine learning with clinical big data and validate Auto-ML on seven benchmark modeling problems of clinical importance; (2) apply Auto-ML and novel methodology to two new modeling problems crucial for care

ROPUESTA DE MODELO EN CINCO CAPAS PARA APLICACIONES WEB I PROPOSAL OF A FIVE LAYERS MODEL FOR WEB APPLICATIONS

Directory of Open Access Journals (Sweden)

Loly Valentina Gómez Fermín

2018-04-01

Full Text Available The ability to create cross-platform programs is a goal for many software developers; however, it is complex to achieve. At present, web applications have been introduced as the chosen way to achieve this desired goal, but being the project tied to a software or hardware platform it is, inevitably, subject to obsolescence. This is not unique to the client application, but also applies to the server side, so that when developing software, even unwillingly, there are strings attached to a database and other applications. Because of this, to develop systems capable of operating with multiple databases and not dependent on a specific platform becomes a Herculean task for a development team. Therefore, this research proposes a working model which enables web applications capable of operating in a layered structure, where each defined layer can be replaced without the need to rewrite the other, and allowing real abstraction for application on any platform software or hardware, both on the client and server sides. For this purpose, the research is supported by Sommerville (2005, who presents a detailed classification of models of software development, according to its organization and modular decomposition, which layed the basis for the development of this proposal. This research is documentary in nature, since it is based on the collection of bibliographic material relating to existing software architectures.

Proposed heat transfer model for the gas-liquid heat transfer effects observed in the Stanford Research Institute scaled tests

International Nuclear Information System (INIS)

Corradini, M.; Sonin, A.A.; Todreas, N.

1976-12-01

In 1971-72, the Stanford Research Institute conducted a series of scaled experiments which simulated a sodium-vapor expansion in a hypothetical core disruptive accident (HCDA) for the Fast Flux Test Facility. A non-condensible explosive source was used to model the pressure-volume expansion characteristics of sodium vapor as predicted by computer code calculations. Rigid piston-cylinder experiments ( 1 / 10 and 1 / 30 scale) were undertaken to determine these expansion characteristics. The results showed that the pressure-volume characteristics depend significantly on the presence of water in the cylinder reducing the work output by about 50 percent when a sufficient water depth was present. The study presented proposes that the mechanism of heat transfer between the water and high temperature gas was due to area enhancement by Taylor instabilities at the gas-liquid interface. A simple heat transfer model is proposed which describes this energy transport process and agrees well with the experimental data from both scaled experiments. The consequences of this analysis suggest that an estimate of the heat transfer to the cold slug during a full-scale HCDA due to sodium vapor expansion and the accompanying reduction in mechanical work energy warrants further investigation. The implication of this analysis is that for either sodium or fuel vapor expansion in an HCDA, there is an inherent heat transfer mechanism which significantly reduces the work output of the expanding bubble

A study on an efficient prediction of welding deformation for T-joint laser welding of sandwich panel Part II: Proposal of a method to use shell element model

Directory of Open Access Journals (Sweden)

Jae Woong Kim

2014-06-01

Full Text Available I-core sandwich panel that has been used more widely is assembled using high power CO2 laser welding. Kim et al. (2013 proposed a circular cone type heat source model for the T-joint laser welding between face plate and core. It can cover the negative defocus which is commonly adopted in T-joint laser welding to provide deeper penetration. In part I, a volumetric heat source model is proposed and it is verified thorough a comparison of melting zone on the cross section with experiment results. The proposed model can be used for heat transfer analysis and thermal elasto-plastic analysis to predict welding deformation that occurs during laser welding. In terms of computational time, since the thermal elasto-plastic analysis using 3D solid elements is quite time consuming, shell element model with multi-layers have been employed instead. However, the conventional layered approach is not appropriate for the application of heat load at T-Joint. This paper, Part II, suggests a new method to arrange different number of layers for face plate and core in order to impose heat load only to the face plate.

A study on an efficient prediction of welding deformation for T-joint laser welding of sandwich panel Part II : Proposal of a method to use shell element model

Directory of Open Access Journals (Sweden)

Kim Jae Woong

2014-06-01

Full Text Available I-core sandwich panel that has been used more widely is assembled using high power CO₂laser welding. Kim et al. (2013 proposed a circular cone type heat source model for the T-joint laser welding between face plate and core. It can cover the negative defocus which is commonly adopted in T-joint laser welding to provide deeper penetration. In part I, a volumetric heat source model is proposed and it is verified thorough a comparison of melting zone on the cross section with experiment results. The proposed model can be used for heat transfer analysis and thermal elasto-plastic analysis to predict welding deformation that occurs during laser welding. In terms of computational time, since the thermal elasto-plastic analysis using 3D solid elements is quite time consuming, shell element model with multi-layers have been employed instead. However, the conventional layered approach is not appropriate for the application of heat load at T-Joint. This paper, Part II, suggests a new method to arrange different number of layers for face plate and core in order to impose heat load only to the face plate.

Absenteeism in Undergraduate Business Education: A Proposed Model and Exploratory Investigation

Science.gov (United States)

Burke, Lisa A.

2010-01-01

One issue in undergraduate business education remaining underexamined is student absenteeism. In this article, the literature on undergraduate absenteeism is reviewed culminating in a proposed conceptual framework to guide future research, and an exploratory investigation of management students' attitudes about absenteeism is conducted.…

Performance assessment of the proposed Monitored Retrievable Storage Facility

International Nuclear Information System (INIS)

Chockie, A.D.; Hostick, C.J.; Winter, C.

1986-02-01

Pacific Northwest laboratory (PNL) has completed a performance evaluation of the proposed monitored retrievable storage (MRS) facility. This study was undertaken as part of the Department of Energy MRS Program at PNL. The objective of the performance evaluation was to determine whether the conceptual MRS facility would be able to process spent fuel at the specified design rate of 3600 metric tons of uranium (MTU) per year. The performance of the proposed facility was assessed using the computer model COMPACT (Computer Optimization of Processing and Cask Transport) to simulate facility operations. The COMPACT model consisted of three application models each of which addressed a different aspect of the facility's operation: MRS/waste transportation interface; cask handling capability; and disassembly/consolidation (hot cell) operations. Our conclusions, based on the assessment of design criteria for the proposed facility, are as follows: Facilities and equipment throughout the facility have capability beyond the 3600 MTU/y design requirement. This added capability provides a reserve to compensate for unexpected perturbations in shipping or handling of the spent fuel. Calculations indicate that the facility's maximum maintainable processing capability is approximately 4800 MTU/y

Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model.

Science.gov (United States)

Mathew, Amanda R; Hogarth, Lee; Leventhal, Adam M; Cook, Jessica W; Hitsman, Brian

2017-03-01

Despite decades of research on co-occurring smoking and depression, cessation rates remain consistently lower for depressed smokers than for smokers in the general population, highlighting the need for theory-driven models of smoking and depression. This paper provides a systematic review with a particular focus upon psychological states that disproportionately motivate smoking in depression, and frame an incentive learning theory account of smoking-depression co-occurrence. We searched PubMed, Scopus, PsychINFO and CINAHL to December 2014, which yielded 852 papers. Using pre-established eligibility criteria, we identified papers focused on clinical issues and motivational mechanisms underlying smoking in established, adult smokers (i.e. maintenance, quit attempts and cessation/relapse) with elevated symptoms of depression. Two reviewers determined independently whether papers met review criteria. We included 297 papers in qualitative synthesis. Our review identified three primary mechanisms that underlie persistent smoking among depressed smokers: low positive affect, high negative affect and cognitive impairment. We propose a novel application of incentive learning theory which posits that depressed smokers experience greater increases in the expected value of smoking in the face of these three motivational states, which promotes goal-directed choice of smoking behavior over alternative actions. The incentive learning theory accounts for current evidence on how depression primes smoking behavior and provides a unique framework for conceptualizing psychological mechanisms of smoking maintenance among depressed smokers. Treatment should focus upon correcting adverse internal states and beliefs about the high value of smoking in those states to improve cessation outcomes for depressed smokers. © 2016 Society for the Study of Addiction.

[Acute kidney injury after pediatric cardiac surgery: risk factors and outcomes. Proposal for a predictive model].

Science.gov (United States)

Cardoso, Bárbara; Laranjo, Sérgio; Gomes, Inês; Freitas, Isabel; Trigo, Conceição; Fragata, Isabel; Fragata, José; Pinto, Fátima

2016-02-01

To characterize the epidemiology and risk factors for acute kidney injury (AKI) after pediatric cardiac surgery in our center, to determine its association with poor short-term outcomes, and to develop a logistic regression model that will predict the risk of AKI for the study population. This single-center, retrospective study included consecutive pediatric patients with congenital heart disease who underwent cardiac surgery between January 2010 and December 2012. Exclusion criteria were a history of renal disease, dialysis or renal transplantation. Of the 325 patients included, median age three years (1 day-18 years), AKI occurred in 40 (12.3%) on the first postoperative day. Overall mortality was 13 (4%), nine of whom were in the AKI group. AKI was significantly associated with length of intensive care unit stay, length of mechanical ventilation and in-hospital death (p<0.01). Patients' age and postoperative serum creatinine, blood urea nitrogen and lactate levels were included in the logistic regression model as predictor variables. The model accurately predicted AKI in this population, with a maximum combined sensitivity of 82.1% and specificity of 75.4%. AKI is common and is associated with poor short-term outcomes in this setting. Younger age and higher postoperative serum creatinine, blood urea nitrogen and lactate levels were powerful predictors of renal injury in this population. The proposed model could be a useful tool for risk stratification of these patients. Copyright © 2015 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.

B220 analysis with the local lymph node assay: proposal for a more flexible prediction model.

Science.gov (United States)

Betts, Catherine J; Dearman, Rebecca J; Kimber, Ian; Ryan, Cindy A; Gerberick, G Frank; Lalko, Jon; Api, Anne Marie

2007-01-01

The mouse local lymph node assay (LLNA) has been developed and validated for the identification of chemicals that have the potential to induce skin sensitisation. In common with other predictive test methods the accuracy of the LLNA is not absolute and experience has revealed that a few chemicals, including for instance a minority of skin irritants, may elicit false-positive reactions in the assay. To improve further the performance of the LLNA, and to eliminate or reduce false-positives, there has been interest in an adjunct method in which the ability of chemicals to cause increases in the frequency of B220(+) lymphocytes in skin-draining lymph nodes is measured. Previous studies suggest that the use of B220 analyses aligned with the standard LLNA may serve to distinguish further between contact allergens and skin irritants. In the original predictive model, chemicals were regarded as being skin sensitisers if they were able to induce a 1.25-fold or greater increase in the percentage of B220(+) cells within lymph nodes compared with concurrent vehicle controls. Although this first prediction model has proven useful, in the light of more recent experience, and specifically as a consequence of some variability observed in the frequency of B220(+) lymphocytes in nodes taken from vehicle control-treated animals, it is timely now to reconsider and refine the model. As a result a new prediction model is proposed in which reliance on the use of absolute thresholds is reduced, and in which small changes in control values can be better accommodated. (c) 2007 John Wiley & Sons, Ltd.

First molecular modeling report on novel arylpyrimidine kynurenine monooxygenase inhibitors through multi-QSAR analysis against Huntington's disease: A proposal to chemists!

Science.gov (United States)

Amin, Sk Abdul; Adhikari, Nilanjan; Jha, Tarun; Gayen, Shovanlal

2016-12-01

Huntington's disease (HD) is caused by mutation of huntingtin protein (mHtt) leading to neuronal cell death. The mHtt induced toxicity can be rescued by inhibiting the kynurenine monooxygenase (KMO) enzyme. Therefore, KMO is a promising drug target to address the neurodegenerative disorders such as Huntington's diseases. Fiftysix arylpyrimidine KMO inhibitors are structurally explored through regression and classification based multi-QSAR modeling, pharmacophore mapping and molecular docking approaches. Moreover, ten new compounds are proposed and validated through the modeling that may be effective in accelerating Huntington's disease drug discovery efforts. Copyright © 2016 Elsevier Ltd. All rights reserved.

Ogólny model analizy kosztówpłac bezpośrednich

Directory of Open Access Journals (Sweden)

Adam Żwirbla

2010-04-01

Full Text Available Koszty stanowią nieodłączny element każdego rodzaju działalności gospodar-czej, a zatem świadome zarządzanie kosztami może stanowić uniwersalną strategię w kształtowaniu wyników finansowych. Kontrola kosztów jest podstawą właściwe-go zarządzania kosztami stąd wynika potrzeba analizy m.in. kosztów płac bezpo-średnich. Celem tego artykułu jest prezentacja nowych koncepcji metodologicznych anali-zy kosztów. Artykuł w swoim charakterze jest teoretyczny, a pewne zawarte w nim tezy mogłyby być tematem do dyskusji. Należy dodać, iż autor tego opracowania proponuje nowe podejście analityczne, tak zwaną wertykalną oraz horyzontalną analizę odchyleń kosztów bezpośrednich.

75 FR 53305 - Agency Information Collection Activities: Proposed Collection; Comment Request

Science.gov (United States)

2010-08-31

... proposed information collection project: ``AHRQ Grants Reporting System (GRS).'' In accordance with the... consistent with the AHRQ enterprise architecture model and aligned with AHRQ systems development standards... Information Collection Activities: Proposed Collection; Comment Request AGENCY: Agency for Healthcare Research...

Bayesian inference of chemical kinetic models from proposed reactions

KAUST Repository

Galagali, Nikhil; Marzouk, Youssef M.

2015-01-01

© 2014 Elsevier Ltd. Bayesian inference provides a natural framework for combining experimental data with prior knowledge to develop chemical kinetic models and quantify the associated uncertainties, not only in parameter values but also in model

Detection of autoreactive CD4 T cells using major histocompatibility complex class II dextramers

Directory of Open Access Journals (Sweden)

Kuszynski Charles

2011-07-01

Full Text Available Abstract Background Tetramers are useful tools to enumerate the frequencies of antigen-specific T cells. However, unlike CD8 T cells, CD4 T cells - especially self-reactive cells - are challenging to detect with major histocompatibility complex (MHC class II tetramers because of low frequencies and low affinities of their T cell receptors to MHC-peptide complexes. Here, we report the use of fluorescent multimers, designated MHC dextramers that contain a large number of peptide-MHC complexes per reagent. Results The utility of MHC dextramers was evaluated in three autoimmune disease models: 1 proteolipid protein (PLP 139-151-induced experimental autoimmune encephalomyelitis in SJL/J (H-2s mice; 2 myelin oligodendrocyte glycoprotein (MOG 35-55-induced experimental autoimmune encephalomyelitis in C57Bl/6 (H-2b mice; and 3 cardiac myosin heavy chain (Myhc-α 334-352-induced experimental autoimmune myocarditis in A/J (H-2a mice. Flow cytometrically, we demonstrate that IAs/PLP 139-151, IAb/MOG 35-55 and IAk/Myhc-α 334-352 dextramers detect the antigen-sensitized cells with specificity, and with a detection sensitivity significantly higher than that achieved with conventional tetramers. Furthermore, we show that binding of dextramers, but not tetramers, is less dependent on the activation status of cells, permitting enumeration of antigen-specific cells ex vivo. Conclusions The data suggest that MHC dextramers are useful tools to track the generation and functionalities of self-reactive CD4 cells in various experimental systems.

Neurotoxocarosis alters myelin protein gene transcription and expression.

Science.gov (United States)

Heuer, Lea; Beyerbach, Martin; Lühder, Fred; Beineke, Andreas; Strube, Christina

2015-06-01

Neurotoxocarosis is an infection of the central nervous system caused by migrating larvae of the common dog and cat roundworms (Toxocara canis and Toxocara cati), which are zoonotic agents. As these parasites are prevalent worldwide and neuropathological and molecular investigations on neurotoxocarosis are scare, this study aims to characterise nerve fibre demyelination associated with neurotoxocarosis on a molecular level. Transcription of eight myelin-associated genes (Cnp, Mag, Mbp, Mog, Mrf-1, Nogo-A, Plp1, Olig2) was determined in the mouse model during six time points of the chronic phase of infection using qRT-PCR. Expression of selected proteins was analysed by Western blotting or immunohistochemistry. Additionally, demyelination and neuronal damage were investigated histologically. Significant differences (p ≤ 0.05) between transcription rates of T. canis-infected and uninfected control mice were detected for all analysed genes while T. cati affected five of eight investigated genes. Interestingly, 2', 3 ´-cyclic nucleotide 3'-phosphodiesterase (Cnp) and myelin oligodendrocyte glycoprotein (Mog) were upregulated in both T. canis- and T. cati-infected mice preceding demyelination. Later, CNPase expression was additionally enhanced. As expected, myelin basic protein (Mbp) was downregulated in cerebra and cerebella of T. canis-infected mice when severe demyelination was present 120 days post infectionem (dpi). The transcriptional pattern observed in the present study appears to reflect direct traumatic and hypoxic effects of larval migration as well as secondary processes including host immune reactions, demyelination and attempts to remyelinate damaged areas.

Business process modeling applied to oil pipeline and terminal processes: a proposal for TRANSPETRO's oil pipelines and terminals in Rio de Janeiro and Minas Gerais

Energy Technology Data Exchange (ETDEWEB)

Santiago, Adilson da Silva [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil); Caulliraux, Heitor Mansur [Universidade Federal do Rio de Janeiro (COPPE/UFRJ/GPI), RJ (Brazil). Coordenacao de Pos-graduacao em Engenharia. Grupo de Producao Integrada; Almeida, Maria Fatima Ludovico de [Pontificia Universidade Catolica do Rio de Janeiro (PUC-Rio/ITUC), Rio de Janeiro, RJ (Brazil). Instituto Tecnologico; Felippe, Adriana Vieira de Oliveira [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil)

2009-07-01

Business process modeling (BPM) using event driven process chain diagrams (EPCs) to lay out business process work flows is now widely adopted around the world. The EPC method was developed within the framework of the ARIS Toolset developed by Prof. Wilhelm-August Scheer at the Institut fur Wirtschaftsinformatik at the Universitat des Saarlandes, in the early 1990s. It is used by many companies to model, analyze and redesign business processes. As such it forms the core technique for modeling in ARIS, which serves to link the different aspects of the so-called control view, which is discussed in the section on ARIS business process modeling. This paper describes a proposal made to TRANSPETRO's Oil Pipelines and Terminals Division in the states of Rio de Janeiro and Minas Gerais, which will be jointly developed by specialists and managers from TRANSPETRO and from COPPETEC, the collaborative research arm of Rio de Janeiro Federal University (UFRJ). The proposal is based on ARIS business process modeling and is presented here according to its seven phases, as follows: information survey and definition of the project structure; mapping and analysis of Campos Eliseos Terminal (TECAM) processes; validation of TECAM process maps; mapping and analysis of the remaining organizational units' processes; validation of the remaining organizational units' process maps; proposal of a business process model for all organizational units of TRANSPETRO's Oil Pipelines and Terminals Division in Rio de Janeiro and Minas Gerais; critical analysis of the process itself and the results and potential benefits of BPM. (author)

Investigating the empirical support for therapeutic targets proposed by the temporal experience of pleasure model in schizophrenia: A systematic review.

Science.gov (United States)

Edwards, Clementine J; Cella, Matteo; Tarrier, Nicholas; Wykes, Til

2015-10-01

Anhedonia and amotivation are substantial predictors of poor functional outcomes in people with schizophrenia and often present a formidable barrier to returning to work or building relationships. The Temporal Experience of Pleasure Model proposes constructs which should be considered therapeutic targets for these symptoms in schizophrenia e.g. anticipatory pleasure, memory, executive functions, motivation and behaviours related to the activity. Recent reviews have highlighted the need for a clear evidence base to drive the development of targeted interventions. To review systematically the empirical evidence for each TEP model component and propose evidence-based therapeutic targets for anhedonia and amotivation in schizophrenia. Following PRISMA guidelines, PubMed and PsycInfo were searched using the terms "schizophrenia" and "anhedonia". Studies were included if they measured anhedonia and participants had a diagnosis of schizophrenia. The methodology, measures and main findings from each study were extracted and critically summarised for each TEP model construct. 80 independent studies were reviewed and executive functions, emotional memory and the translation of motivation into actions are highlighted as key deficits with a strong evidence base in people with schizophrenia. However, there are many relationships that are unclear because the empirical work is limited by over-general tasks and measures. Promising methods for research which have more ecological validity include experience sampling and behavioural tasks assessing motivation. Specific adaptations to Cognitive Remediation Therapy, Cognitive Behavioural Therapy and the utilisation of mobile technology to enhance representations and emotional memory are recommended for future development. Copyright © 2015. Published by Elsevier B.V.

PTM Modeling of Dredged Suspended Sediment at Proposed Polaris Point and Ship Repair Facility CVN Berthing Sites - Apra Harbor, Guam

Science.gov (United States)

2017-09-01

sedimentation outside of the channel footprint. For example, dredging near the edge of the footprint can be confined to time periods when tidal currents...Cases 1 or 2 due to the lower loss rate. Sedimentation rates outside the channel prism are further reduced because all sediment is introduced in the...ER D C/ CH L TR -1 7- 16 PTM Modeling of Dredged Suspended Sediment at Proposed Polaris Point and Ship Repair Facility CVN Berthing

Proposal of a model of mammalian neural induction

Science.gov (United States)

Levine, Ariel J.; Brivanlou, Ali H.

2009-01-01

How does the vertebrate embryo make a nervous system? This complex question has been at the center of developmental biology for many years. The earliest step in this process – the induction of neural tissue – is intimately linked to patterning of the entire early embryo, and the molecular and embryological basis these processes are beginning to emerge. Here, we analyze classic and cutting-edge findings on neural induction in the mouse. We find that data from genetics, tissue explants, tissue grafting, and molecular marker expression support a coherent framework for mammalian neural induction. In this model, the gastrula organizer of the mouse embryo inhibits BMP signaling to allow neural tissue to form as a default fate – in the absence of instructive signals. The first neural tissue induced is anterior and subsequent neural tissue is posteriorized to form the midbrain, hindbrain, and spinal cord. The anterior visceral endoderm protects the pre-specified anterior neural fate from similar posteriorization, allowing formation of forebrain. This model is very similar to the default model of neural induction in the frog, thus bridging the evolutionary gap between amphibians and mammals. PMID:17585896

A chimeric receptor of the insulin-like growth factor receptor type 1 (IGFR1) and a single chain antibody specific to myelin oligodendrocyte glycoprotein activates the IGF1R signalling cascade in CG4 oligodendrocyte progenitors

NARCIS (Netherlands)

Annenkov, A.; Rigby, A.; Amor, S.; Zhou, D.M.; Yousaf, N.; Hemmer, B.; Chernajovsky, Y.

2011-01-01

In order to generate neural stem cells with increased ability to survive after transplantation in brain parenchyma we developed a chimeric receptor (ChR) that binds to myelin oligodendrocyte glycoprotein (MOG) via its ectodomain and activates the insulin-like growth factor receptor type 1 (IGF1R)

Does Risk Aversion Matter for Foreign Asset Holdings of Pension Funds – The Case of Poland

Directory of Open Access Journals (Sweden)

Kurach Radosław

2014-06-01

Full Text Available W artykule podjęto zagadnienie inwestycji w aktywa zagraniczne dokonywanych przez fundusze emerytalne. W części pierwszej opracowania dokonano przeglądu polityk nadzorczych oraz wskazano efekty zewnętrzne inwestycji zagranicznych, które mogą odpowiadać za obserwowane różnice w regulacjach pomiędzy krajami Europy Środkowo-Wschodniej. Następnie wykorzystując teorię portfela przeprowadzono symulacje mające na celu oszacowanie korzyści dywersyfikacyjnych, jakie mogłyby zostać osiągnięte poprzez wyższy udziałaktywów zagranicznych. Stosując specyficzne ograniczenia oraz biorąc pod uwagę zmienność kursu walutowego, zaprezentowane badanie oddaje perspektywę członka polskiego funduszu emerytalnego. Z drugiej strony, wnioski dotyczące stopnia awersji do ryzyka oraz wskazane kierunki dla dalszych badań powinny mieć charakter uniwersalny.

Proposal for a transmon-based quantum router

NARCIS (Netherlands)

Sala, Arnau; Blaauboer, M.

2016-01-01

We propose an implementation of a quantum router for microwave photons in a superconducting qubit architecture consisting of a transmon qubit, SQUIDs and a nonlinear capacitor. We model and analyze the dynamics of operation of the quantum switch using quantum Langevin equations in a scattering

The Proposed Plea Bargaining in Ethiopia …

African Journals Online (AJOL)

Alemu Meheretu

Plea bargaining, models of plea bargaining, the proposed plea bargaining, efficiency ... based on my PhD thesis titled: ` Introducing Plea bargaining in Ethiopia: Concerns and prospects`. .... defendant in return to not only pleading guilty but also waiving some rights as .... contradict the adversarial style of plea bargaining.

Proposed evaluation framework for assessing operator performance with multisensor displays

Science.gov (United States)

Foyle, David C.

1992-01-01

Despite aggressive work on the development of sensor fusion algorithms and techniques, no formal evaluation procedures have been proposed. Based on existing integration models in the literature, an evaluation framework is developed to assess an operator's ability to use multisensor, or sensor fusion, displays. The proposed evaluation framework for evaluating the operator's ability to use such systems is a normative approach: The operator's performance with the sensor fusion display can be compared to the models' predictions based on the operator's performance when viewing the original sensor displays prior to fusion. This allows for the determination as to when a sensor fusion system leads to: 1) poorer performance than one of the original sensor displays (clearly an undesirable system in which the fused sensor system causes some distortion or interference); 2) better performance than with either single sensor system alone, but at a sub-optimal (compared to the model predictions) level; 3) optimal performance (compared to model predictions); or, 4) super-optimal performance, which may occur if the operator were able to use some highly diagnostic 'emergent features' in the sensor fusion display, which were unavailable in the original sensor displays. An experiment demonstrating the usefulness of the proposed evaluation framework is discussed.

Disturbed flow mediated modulation of shear forces on endothelial plane: A proposed model for studying endothelium around atherosclerotic plaques

Science.gov (United States)

Balaguru, Uma Maheswari; Sundaresan, Lakshmikirupa; Manivannan, Jeganathan; Majunathan, Reji; Mani, Krishnapriya; Swaminathan, Akila; Venkatesan, Saravanakumar; Kasiviswanathan, Dharanibalan; Chatterjee, Suvro

2016-06-01

Disturbed fluid flow or modulated shear stress is associated with vascular conditions such as atherosclerosis, thrombosis, and aneurysm. In vitro simulation of the fluid flow around the plaque micro-environment remains a challenging approach. Currently available models have limitations such as complications in protocols, high cost, incompetence of co-culture and not being suitable for massive expression studies. Hence, the present study aimed to develop a simple, versatile model based on Computational Fluid Dynamics (CFD) simulation. Current observations of CFD have shown the regions of modulated shear stress by the disturbed fluid flow. To execute and validate the model in real sense, cell morphology, cytoskeletal arrangement, cell death, reactive oxygen species (ROS) profile, nitric oxide production and disturbed flow markers under the above condition were assessed. Endothelium at disturbed flow region which had been exposed to low shear stress and swirling flow pattern showed morphological and expression similarities with the pathological disturbed flow environment reported previously. Altogether, the proposed model can serve as a platform to simulate the real time micro-environment of disturbed flow associated with eccentric plaque shapes and the possibilities of studying its downstream events.

Sudbury neutrino observatory proposal

International Nuclear Information System (INIS)

Ewan, G.T.; Evans, H.C.; Lee, H.W.

1987-10-01

This report is a proposal by the Sudbury Neutrino Observatory (SNO) collaboration to develop a world class laboratory for neutrino astrophysics. This observatory would contain a large volume heavy water detector which would have the potential to measure both the electron-neutrino flux from the sun and the total solar neutrino flux independent of neutrino type. It will therefore be possible to test models of solar energy generation and, independently, to search for neutrino oscillations with a sensitivity many orders of magnitude greater than that of terrestrial experiments. It will also be possible to search for spectral distortion produced by neutrino oscillations in the dense matter of the sun. Finally the proposed detector would be sensitive to neutrinos from a stellar collapse and would detect neutrinos of all types thus providing detailed information on the masses of muon- and tau-neutrinos. The neutrino detector would contain 1000 tons of D20 and would be located more than 2000 m below ground in the Creighton mine near Sudbury. The operation and performance of the proposed detector are described and the laboratory design is presented. Construction schedules and responsibilities and the planned program of technical studies by the SNO collaboration are outlined. Finally, the total capital cost is estimated to be $35M Canadian and the annual operating cost, after construction, would be $1.8 M Canadian, including the insurance costs of the heavy water

Digital curation: a proposal of a semi-automatic digital object selection-based model for digital curation in Big Data environments

Directory of Open Access Journals (Sweden)

Moisés Lima Dutra

2016-08-01

Full Text Available Introduction: This work presents a new approach for Digital Curations from a Big Data perspective. Objective: The objective is to propose techniques to digital curations for selecting and evaluating digital objects that take into account volume, velocity, variety, reality, and the value of the data collected from multiple knowledge domains. Methodology: This is an exploratory research of applied nature, which addresses the research problem in a qualitative way. Heuristics allow this semi-automatic process to be done either by human curators or by software agents. Results: As a result, it was proposed a model for searching, processing, evaluating and selecting digital objects to be processed by digital curations. Conclusions: It is possible to use Big Data environments as a source of information resources for Digital Curation; besides, Big Data techniques and tools can support the search and selection process of information resources by Digital Curations.

Proposal for a Revised Programme of Studies at the Faculty of Engineering, Ondo State University Using the Pedagogical Model at AUC as Reference

DEFF Research Database (Denmark)

Jørgensen, Mogens B.; Borch, Ole; Esan, A. A.

by AUC Staff. It will, of course, remain a requirement that minimum requirements laid down by the National Universities Commission are met. This was taken into account when preparing the proposal. The report is seen as a first important step towards the introduction of the AUC pedagogical model at OSUA...

Proposal of a model for evaluation of research and development projects in a public scientific and technological institution: a survey in CNEN

International Nuclear Information System (INIS)

Silva, Eduardo de Assumpcao

2017-01-01

Science and technology are directly related to the development of a country. The research and development projects in CNEN are financed by the direct resources of the budget of the Union and of the Development Agencies such as FINEP and CNPq. In general, project managers believe they can succeed when they complete a project on schedule, budget, and anticipated requirements, which is commonly known as a 'triple constraint' or 'iron triangle'. However, in the review of the literature, other criteria for evaluating success in projects, such as the benefits generated by society, the development of the team's capabilities, future opportunities, new technologies, among others, were verified. In this way, in order to assist the manager in the evaluation of this type of project, the present research carried out a review in the literature aiming to find concepts about success in projects and their evaluation criteria, proposed a model based on the theoretical reference and Importance and use of these criteria with the CNEN specialists, who work directly in the R and D projects of a public ICT in the nuclear area. The results showed that the criteria proposed in the model have a high degree of importance and show a decrease in the degree of utilization, suggesting that the criteria used in the model can help managers in the evaluation of these projects. (author)

The IMACLIM model; Le modele IMACLIM

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

This document provides annexes to the IMACLIM model which propose an actualized description of IMACLIM, model allowing the design of an evaluation tool of the greenhouse gases reduction policies. The model is described in a version coupled with the POLES, technical and economical model of the energy industry. Notations, equations, sources, processing and specifications are proposed and detailed. (A.L.B.)

The Role of Interpersonal Relations in Healthcare Team Communication and Patient Safety: A Proposed Model of Interpersonal Process in Teamwork.

Science.gov (United States)

Lee, Charlotte Tsz-Sum; Doran, Diane Marie

2017-06-01

Patient safety is compromised by medical errors and adverse events related to miscommunications among healthcare providers. Communication among healthcare providers is affected by human factors, such as interpersonal relations. Yet, discussions of interpersonal relations and communication are lacking in healthcare team literature. This paper proposes a theoretical framework that explains how interpersonal relations among healthcare team members affect communication and team performance, such as patient safety. We synthesized studies from health and social science disciplines to construct a theoretical framework that explicates the links among these constructs. From our synthesis, we identified two relevant theories: framework on interpersonal processes based on social relation model and the theory of relational coordination. The former involves three steps: perception, evaluation, and feedback; and the latter captures relational communicative behavior. We propose that manifestations of provider relations are embedded in the third step of the framework on interpersonal processes: feedback. Thus, varying team-member relationships lead to varying collaborative behavior, which affects patient-safety outcomes via a change in team communication. The proposed framework offers new perspectives for understanding how workplace relations affect healthcare team performance. The framework can be used by nurses, administrators, and educators to improve patient safety, team communication, or to resolve conflicts.

PROPOSAL OF A SIMULATOR FOR ELECTROSTIMULATION IN A VIRTUAL HUMAN UPPER LIMB

Directory of Open Access Journals (Sweden)

Roberto Luiz Souza Monteiro

2017-04-01

Full Text Available The practice in the use of electrostimulators: inappropriately, can lead to physical damage to the subject beyond the use of inappropriately. The use of computer simulation can help with the technical training of those who will operate this type of equipment. This paper presents a conceptual model applied to human upper limb muscle groups modeled in 3D, connected to an electronic device that sends signals to simulate the operation of electrostimulation practices, with the aim of proposing this model as a tool for teaching and learning in the area of electrotherapy. The conceptual model is presented as a proposal for the practice of electrotherapy area, with the qualitative aspects: security, configurability and a model of reading at the time of your execution.

Neuroprotective effects of gypenosides in experimental autoimmune optic neuritis

Directory of Open Access Journals (Sweden)

Hong-Kan Zhang

2017-04-01

Full Text Available AIM: To determine whether gypenosides have protective effects in experimental autoimmune optic neuritis (EAON. METHODS: Mice were randomly divided into seven groups: control group, model group, three different density gypenosides monotherapy, methylprednisolone monotherapy, combination of gypenosides and methylprednisolone group. The control group was subcutaneously injected with oil emulsion adjuvant and all other groups were subcutaneously immunized with an emulsified mixture of myelin oligodendrocyte glycoprotein (MOG 35-55 peptide to induce EAON. Mice in the gypenosides groups were administered injections daily with three concentrations (15 mg/kg, 30 mg/kg, 45 mg/kg of gypenosides respectively. Mice in the methylprednisolone group and the combination treatment group were injected daily with methylprednisolone (20 mg/kg or methylprednisolone (20 mg/kg + gypenosides (30 mg/kg, respectively. After MOG immunization, visual evoked potential (VEP, optical coherence tomography (OCT, and histopathologic examination were performed at 14, 20, 30, and 40d post-inoculation (p.i.. All results were expressed as mean±SEM. The data were evaluated by one-way ANOVA followed by Tukey or Games-Howell test. RESULTS: Compared with the control group, p2 latency was prolonged in the model group (P=0.041. Combination treatment can alleviated the change in VEP at 20d p.i. (P=0.012. Average peripapillary retinal nerve fiber layer (RNFL thickness was reduced in the model group (P= 0.000, 30d; P=0.000, 40d and gypenosides treatment remarkably diminished the degree of RNFL degeneration at 30d and 40d p.i (P=0.000, 30d; P=0.000, 40d. The pathomorphological results showed a decrease in demye-lination (P=0.020 and inflammatory reactions in the combination group compared with the model group (20d p.i.. Gypenosides treatment also alleviated the degree of axonal loss (40d p.i. (P=0.003. CONCLUSION: Treatment with gypenosides exerts protective effects on retinal nerve fibers

Leadership and positive human functioning: a triphasic proposal

OpenAIRE

Gomes, António Rui

2014-01-01

This chapter addresses the topic of leadership by proposing the Triphasic Model of Leadership Efficacy. The model explains leadership efficacy by suggesting that the best results achieved by the leaders result from a congruent hypothesis that congregates a conceptual cycle of leadership (that includes the elements of leadership philosophy, leadership practice, and leadership criteria) and a practical cycle of leadership (that includes the elements of leadership philosophy, leadership in pract...

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.

Science.gov (United States)

van Moorsel, Dirk; Hansen, Jan; Havekes, Bas; Scheer, Frank A J L; Jörgensen, Johanna A; Hoeks, Joris; Schrauwen-Hinderling, Vera B; Duez, Helene; Lefebvre, Philippe; Schaper, Nicolaas C; Hesselink, Matthijs K C; Staels, Bart; Schrauwen, Patrick

2016-08-01

A disturbed day-night rhythm is associated with metabolic perturbations that can lead to obesity and type 2 diabetes mellitus (T2DM). In skeletal muscle, a reduced oxidative capacity is also associated with the development of T2DM. However, whether oxidative capacity in skeletal muscle displays a day-night rhythm in humans has so far not been investigated. Lean, healthy subjects were enrolled in a standardized living protocol with regular meals, physical activity and sleep to reflect our everyday lifestyle. Mitochondrial oxidative capacity was examined in skeletal muscle biopsies taken at five time points within a 24-hour period. Core-body temperature was lower during the early night, confirming a normal day-night rhythm. Skeletal muscle oxidative capacity demonstrated a robust day-night rhythm, with a significant time effect in ADP-stimulated respiration (state 3 MO, state 3 MOG and state 3 MOGS, p < 0.05). Respiration was lowest at 1 PM and highest at 11 PM (state 3 MOGS: 80.6 ± 4.0 vs. 95.8 ± 4.7 pmol/mg/s). Interestingly, the fluctuation in mitochondrial function was also observed in whole-body energy expenditure, with peak energy expenditure at 11 PM and lowest energy expenditure at 4 AM (p < 0.001). In addition, we demonstrate rhythmicity in mRNA expression of molecular clock genes in human skeletal muscle. Our results suggest that the biological clock drives robust rhythms in human skeletal muscle oxidative metabolism. It is tempting to speculate that disruption of these rhythms contribute to the deterioration of metabolic health associated with circadian misalignment.

Psychiatryczne oraz prawne aspekty stosowania przymusu bezpośredniego wobec uczniów na terenie szkoły specjalnej

Directory of Open Access Journals (Sweden)

Błażej Kmieciak

2015-12-01

Full Text Available Zastosowanie przymusu bezpośredniego to sytuacja szczególna, wymagająca użycia siły wobec drugiego człowieka. Możliwość podjęcia podobnych działań musi być regulowana przez określone akty prawne. W kontekście rzeczywistości psychiatrycznej należy wskazać przede wszystkim na zapisy ustawy o ochronie zdrowia psychicznego. Zwrócono w niej uwagę, że lekarz i pielęgniarka mogą podjąć wobec agresywnego lub autoagresywnego pacjenta takie działania, jak unieruchomienie, przytrzymanie, izolacja i przymusowe podanie leków. Jednak niebezpieczne zachowania mogą prezentować również uczniowie szkół specjalnych, których część była niegdyś pacjentami szpitali psychiatrycznych. Nie zmienia to faktu, że na terenie szkół pedagodzy nie mają formalnego prawa do zastosowania przymusu bezpośredniego wobec ucznia. Co zatem mogą zrobić, kiedy podopieczny stosuje siłę? W jaki sposób nauczyciel powinien postąpić w przypadku agresji ucznia, by chronić bezpieczeństwo własne oraz innych osób? Czy w  pewnych sytuacjach wolno mu przytrzymać podopiecznego albo go unieruchomić? Czy w  wybranych przypadkach pedagog ma obowiązek użycia siły wobec niepełnosprawnego ucznia? W artykule podjęta zostanie próba udzielenia odpowiedzi na powyższe pytania.

Professional skills training proposal for professors of health programs

Directory of Open Access Journals (Sweden)

Mauricio Alberto Ángel-Macías

2017-10-01

Conclusions: This study shows the urgent need for creating training spaces in pedagogy, didactics and evaluation. In consequence, a model that includes cognitive, methodological, social and personal skills is proposed.

Degradation of light emitting diodes: a proposed methodology

International Nuclear Information System (INIS)

Koh, Sau; Vam Driel, Willem; Zhang, G.Q.

2011-01-01

Due to their long lifetime and high efficacy, light emitting diodes have the potential to revolutionize the illumination industry. However, self heat and high environmental temperature which will lead to increased junction temperature and degradation due to electrical overstress can shorten the life of the light emitting diode. In this research, a methodology to investigate the degradation of the LED emitter has been proposed. The epoxy lens of the emitter can be modelled using simplified Eyring methods whereas an equation has been proposed for describing the degradation of the LED emitters. (semiconductor devices)

The catastrophic dieback of Typha domingensis in a drained and restored East Mediterranean wetland: re-examining proposed models

Directory of Open Access Journals (Sweden)

R. Simhayov

2012-01-01

Full Text Available We experimentally tested two geochemical models which have been proposed as potential mechanisms leading to the catastrophic dieback of Typha domingensis in constructed Lake Agmon within the drained Hula peatland, northern Israel. An elaborate lysimeter station simulating the conditions imposed by sulphide toxicity and P deficiency models was used to test them experimentally. Rhizosphere pH and redox potential were monitored in situ in real time throughout the summers of 2007 and 2008. A comparative study of redox-reduction simulation was coupled with periodic sampling and analysis of sulphide and other reducing species. N and P were determined in the plant tissues to compute the N:P nutrient limitation index and evaluate nutrient deficiencies. The sulphide toxicity model was not accepted as a viable mechanism because Typha domingensis stands did not show any signs of stress, even when growing in rhizosphere with a sulphide concentration three times that during the actual dieback in 1996. The P limitation model was not supported by the N:P index, which indicated N (16 limitation. Since Typha has now returned and is thriving in Lake Agmon and adjacent drainage canals, we suggest a self-thinning mechanism followed by normal succession of macrophytes in this relatively young constructed wetland as the most logical mechanism to explain the observed dieback.

Proposal for a new CAPE-OPEN Object Model

Science.gov (United States)

Process simulation applications require the exchange of significant amounts of data between the flowsheet environment, unit operation model, and thermodynamic server. Packing and unpacking various data types and exchanging data using structured text-based architectures, including...

Proposals to overcome limitations in the EU chemical risk assessment scheme

DEFF Research Database (Denmark)

Trapp, Stefan; Schwartz, S.

2000-01-01

The noti®cation of new chemicals in the European Union requires a risk assessment. A Technical Guidance Document (TGD) was prepared for assistance. The TGD proposes QSARs, regressions and models from various sources. Each method has its own range of applicability and its own restrictions. Regress......The noti®cation of new chemicals in the European Union requires a risk assessment. A Technical Guidance Document (TGD) was prepared for assistance. The TGD proposes QSARs, regressions and models from various sources. Each method has its own range of applicability and its own restrictions...

MO-G-304-04: Generating Well-Dispersed Representations of the Pareto Front for Multi-Criteria Optimization in Radiation Treatment Planning

Energy Technology Data Exchange (ETDEWEB)

Kirlik, G; Zhang, H [University of Maryland School of Medicine, Baltimore, MD (United States)

2015-06-15

Purpose: To present a novel multi-criteria optimization (MCO) solution approach that generates well-dispersed representation of the Pareto front for radiation treatment planning. Methods: Different algorithms have been proposed and implemented in commercial planning software to generate MCO plans for external-beam radiation therapy. These algorithms consider convex optimization problems. We propose a grid-based algorithm to generate well-dispersed treatment plans over Pareto front. Our method is able to handle nonconvexity in the problem to deal with dose-volume objectives/constraints, biological objectives, such as equivalent uniform dose (EUD), tumor control probability (TCP), normal tissue complication probability (NTCP), etc. In addition, our algorithm is able to provide single MCO plan when clinicians are targeting narrow bounds of objectives for patients. In this situation, usually none of the generated plans were within the bounds and a solution is difficult to identify via manual navigation. We use the subproblem formulation utilized in the grid-based algorithm to obtain a plan within the specified bounds. The subproblem aims to generate a solution that maps into the rectangle defined by the bounds. If such a solution does not exist, it generates the solution closest to the rectangle. We tested our method with 10 locally advanced head and neck cancer cases. Results: 8 objectives were used including 3 different objectives for primary target volume, high-risk and low-risk target volumes, and 5 objectives for each of the organs-at-risk (OARs) (two parotids, spinal cord, brain stem and oral cavity). Given tight bounds, uniform dose was achieved for all targets while as much as 26% improvement was achieved in OAR sparing comparing to clinical plans without MCO and previously proposed MCO method. Conclusion: Our method is able to obtain well-dispersed treatment plans to attain better approximation for convex and nonconvex Pareto fronts. Single treatment plan can

A new approach for modeling the peak utility impacts from a proposed CUAC standard

Energy Technology Data Exchange (ETDEWEB)

LaCommare, Kristina Hamachi; Gumerman, Etan; Marnay, Chris; Chan, Peter; Coughlin, Katie

2004-08-01

This report describes a new Berkeley Lab approach for modeling the likely peak electricity load reductions from proposed energy efficiency programs in the National Energy Modeling System (NEMS). This method is presented in the context of the commercial unitary air conditioning (CUAC) energy efficiency standards. A previous report investigating the residential central air conditioning (RCAC) load shapes in NEMS revealed that the peak reduction results were lower than expected. This effect was believed to be due in part to the presence of the squelch, a program algorithm designed to ensure changes in the system load over time are consistent with the input historic trend. The squelch applies a system load-scaling factor that scales any differences between the end-use bottom-up and system loads to maintain consistency with historic trends. To obtain more accurate peak reduction estimates, a new approach for modeling the impact of peaky end uses in NEMS-BT has been developed. The new approach decrements the system load directly, reducing the impact of the squelch on the final results. This report also discusses a number of additional factors, in particular non-coincidence between end-use loads and system loads as represented within NEMS, and their impacts on the peak reductions calculated by NEMS. Using Berkeley Lab's new double-decrement approach reduces the conservation load factor (CLF) on an input load decrement from 25% down to 19% for a SEER 13 CUAC trial standard level, as seen in NEMS-BT output. About 4 GW more in peak capacity reduction results from this new approach as compared to Berkeley Lab's traditional end-use decrement approach, which relied solely on lowering end use energy consumption. The new method has been fully implemented and tested in the Annual Energy Outlook 2003 (AEO2003) version of NEMS and will routinely be applied to future versions. This capability is now available for use in future end-use efficiency or other policy analysis

Neuroprotekcyjne właściwości związków pochodzenia roślinnego: triterpeny pentacykliczne

Directory of Open Access Journals (Sweden)

Monika Orłowska-Majdak

2014-12-01

Full Text Available Ludzki mózg to struktura wykazująca ogromną zmienność w ciągu życia osobniczego. W pierwszym okresie zmiany budowy i czynności spowodowane są procesami rozwoju i dojrzewania. Następnie, dzięki niezwykłej plastyczności synaptycznej, poszczególne ośrodki mózgu przystosowują się do wymagań środowiska, w jakim człowiek funkcjonuje, i do stylu jego życia. Po 40. roku życia włącza się proces zaprogramowanej śmierci neuronów, czyli apoptozy, a w stanie choroby neurony mogą ginąć w procesie nekrozy lub aponekrozy. Neurogeneza na bazie miejscowych albo transplantowanych komórek macierzystych mózgu pełni funkcję naprawczą w powstałych uszkodzeniach, ale może także mieć związek z chorobami psychicznymi i neurologicznymi. U podstaw neuroprotekcji leżą procesy antyoksydacyjne, przeciwzapalne, antyapoptotyczne i przeciwdziałające destrukcyjnemu działaniu jonów wapnia. Wspierającą funkcję w działaniu neuroprotekcyjnym mogą mieć związki pochodzenia roślinnego, podawane w ramach fitoterapii. W ostatnich latach zwrócono uwagę na neuroprotekcyjne właściwości pentacyklicznych triterpenów i ich pochodnych. W pracy omówiono właściwości neuroprotekcyjne kwasu ursolowego, oleanolowego, maslinowego, asjatowego, betulinowego, bosweliowego oraz saponin triterpenowych pozyskiwanych z roślin Bupleurum i Panax ginseng. Saponiny ginseng dodatkowo nasilają neurogenezę w mózgu. Sugeruje się potencjał stosowania wymienionych związków w terapii wielu chorób neurologicznych i psychicznych – z kilkoma zastrzeżeniami: 1 kierunek działania może zależeć od dawki; 2 związki te mogą różnie działać na neurony różnych rodzajów; 3 mogą istnieć niekorzystne interakcje z innymi lekami stosowanymi równocześnie. Większość doświadczeń z użyciem triterpenów wykonano na zwierzętach bądź w hodowlach komórkowych, zagadnienie wymaga więc dalszych badań na ludziach.

Ewolucja: inżynier systemów komputerowych projektujący umysły

Directory of Open Access Journals (Sweden)

Aaron Sloman

2011-10-01

Full Text Available [Przekład] To, czego w ciągu ostatnich sześciu lub siedmiu tego nauczyliśmy się na temat wirtualnej maszynerii w wyniku dużego postępu nauki i techniki, umożliwia nam zaoferowanie stanowisku darwinowskiemu nowej obrony przeciw krytykom, którzy twierdzili, że jedynie forma fizyczna – a nie zdolności umysłowe czy świadomość – może być produktem ewolucji poprzez dobór naturalny. Obrona ta porównuje zjawiska umysłowe, wspominane przez przeciwników Darwina, z treściami maszynerii wirtualnej w systemach obliczeniowych. Obiekty, stany, zdarzenia i procesy w owej maszynerii, które dopiero od niedawna umiemy projektować i konstruować, a które nie mogły być nawet przedmiotem rozmyślań w czasach Darwina, mogą współdziałać z maszynerią fizyczną, w której są zaimplementowane, nie będąc identycznymi ze swoją fizyczną implementacją, ani też nie będąc jedynie agregatami fizycznych struktur i procesów. Istnienie różnych rodzajów maszynerii wirtualnej (w tym zarówno „platformowych” maszyn wirtualnych, mogących hostować inne takie maszyny, na przykład systemy operacyjne, jak i „aplikacyjnych” maszyn wirtualnych, na przykład korektorów pisowni i gier komputerowych zależy od skomplikowanych sieci połączeń przyczynowych związanych ze strukturami hardware’u i software’u, zdarzeniami i procesami, gdzie specyfikacja takich sieci przyczynowych wymaga konceptów, które nie mogą być zdefiniowane w kategoriach konceptów nauk fizycznych. Ta niedefiniowalność, a także możliwość zachodzenia różnych rodzajów automonitorowania w maszynerii wirtualnej, wydaje się wyjaśniać niektóre z rzekomo tajemniczych i nieredukowalnych cech świadomości, które motywowały krytyków Darwina, a także bardziej współczesnych filozofów, krytykujących sztuczną inteligencję. Wynikają z tego konsekwencje dla filozofii, psychologii, neurobiologii i robotyki.

Implementation of a Proposed Model of a Constructivist Teaching-Learning Process – A Step Towards an Outcome Based Education in Chemistry Laboratory Instruction

Directory of Open Access Journals (Sweden)

Dr. Paz B. Reyes

2013-12-01

Full Text Available This study implemented the proposed model of a constructivist teachinglearning process and determined the extent by which the students manifested the institutional learning outcomes which include competency, credibility, commitment and collaboration. It also investigated if there was an improvement in the learning outcomes after the implementation of the constructivist teachinglearning process and determined the students’ acceptance of the constructivist teaching-learning process. Towards the end a plan of action was proposed to enhance the students’ manifestation of the institutional learning outcomes. It made use of the qualitative- quantitative method particularly the descriptive design. The results of the study revealed that the students manifest competency, credibility, commitment and collaboration as they accept positively the constructivist teaching-learning process in their chemistry laboratory subject. It can be deduced from the findings that the constructivist teaching-learning process improved the learning outcomes of the students. The use of the proposed plan of action is recommended for an effective chemistry laboratory instruction.

Full Field and Anomaly Initialisation using a low order climate model: a comparison, and proposals for advanced formulations

Science.gov (United States)

Weber, Robin; Carrassi, Alberto; Guemas, Virginie; Doblas-Reyes, Francisco; Volpi, Danila

2014-05-01

Full Field (FFI) and Anomaly Initialisation (AI) are two schemes used to initialise seasonal-to-decadal (s2d) prediction. FFI initialises the model on the best estimate of the actual climate state and minimises the initial error. However, due to inevitable model deficiencies, the trajectories drift away from the observations towards the model's own attractor, inducing a bias in the forecast. AI has been devised to tackle the impact of drift through the addition of this bias onto the observations, in the hope of gaining an initial state closer to the model attractor. Its goal is to forecast climate anomalies. The large variety of experimental setups, global coupled models, and observational networks adopted world-wide have led to varying results with regards to the relative performance of AI and FFI. Our research is firstly motivated in a comparison of these two initialisation approaches under varying circumstances of observational errors, observational distributions, and model errors. We also propose and compare two advanced schemes for s2d prediction. Least Square Initialisation (LSI) intends to propagate observational information of partially initialized systems to the whole model domain, based on standard practices in data assimilation and using the covariance of the model anomalies. Exploring the Parameters Uncertainty (EPU) is an online drift correction technique applied during the forecast run after initialisation. It is designed to estimate, and subtract, the bias in the forecast related to parametric error. Experiments are carried out using an idealized coupled dynamics in order to facilitate better control and robust statistical inference. Results show that an improvement of FFI will necessitate refinements in the observations, whereas improvements in AI are subject to model advances. A successful approximation of the model attractor using AI is guaranteed only when the differences between model and nature probability distribution functions (PDFs) are

Feasibility analysis in the expansion proposal of the nuclear power plant Laguna Verde: application of real options, binomial model

International Nuclear Information System (INIS)

Hernandez I, S.; Ortiz C, E.; Chavez M, C.

2011-11-01

At the present time, is an unquestionable fact that the nuclear electrical energy is a topic of vital importance, no more because eliminates the dependence of the hydrocarbons and is friendly with the environment, but because is also a sure and reliable energy source, and represents a viable alternative before the claims in the growing demand of electricity in Mexico. Before this panorama, was intended several scenarios to elevate the capacity of electric generation of nuclear origin with a variable participation. One of the contemplated scenarios is represented by the expansion project of the nuclear power plant Laguna Verde through the addition of a third reactor that serves as detonator of an integral program that proposes the installation of more nuclear reactors in the country. Before this possible scenario, the Federal Commission of Electricity like responsible organism of supplying energy to the population should have tools that offer it the flexibility to be adapted to the possible changes that will be presented along the project and also gives a value to the risk to future. The methodology denominated Real Options, Binomial model was proposed as an evaluation tool that allows to quantify the value of the expansion proposal, demonstrating the feasibility of the project through a periodic visualization of their evolution, all with the objective of supplying a financial analysis that serves as base and justification before the evident apogee of the nuclear energy that will be presented in future years. (Author)

A proposed model for paradigmatic relations within an emergent discipline

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Jack D. Glazier

2002-01-01

Full Text Available This article is the vehicle for purposing a model for mapping the processual change associated with disciplinary and paradigmatic development. Change of this sort is contingent on the degree of consistency achieved within theory groups. Consistency, in this case, is equated theory and paradigm dominance. The symbolic interactionist tradition supplies the assumptions on which the model is grounded. Examination of the model is accomplished by contrasting it with Thomas Kuhn’s theory. The recent history of library and information science education in the U.S. serves as context and exemplar for application of the model

A model for determining when an analysis contains sufficient detail to provide adequate NEPA coverage for a proposed action

International Nuclear Information System (INIS)

Eccleston, C.H.

1994-11-01

Neither the National Environmental Policy Act (NEPA) nor its subsequent regulations provide substantive guidance for determining the Level of detail, discussion, and analysis that is sufficient to adequately cover a proposed action. Yet, decisionmakers are routinely confronted with the problem of making such determinations. Experience has shown that no two decisionmakers are Likely to completely agree on the amount of discussion that is sufficient to adequately cover a proposed action. one decisionmaker may determine that a certain Level of analysis is adequate, while another may conclude the exact opposite. Achieving a consensus within the agency and among the public can be problematic. Lacking definitive guidance, decisionmakers and critics alike may point to a universe of potential factors as the basis for defending their claim that an action is or is not adequately covered. Experience indicates that assertions are often based on ambiguous opinions that can be neither proved nor disproved. Lack of definitive guidance slows the decisionmaking process and can result in project delays. Furthermore, it can also Lead to inconsistencies in decisionmaking, inappropriate Levels of NEPA documentation, and increased risk of a project being challenged for inadequate coverage. A more systematic and less subjective approach for making such determinations is obviously needed. A paradigm for reducing the degree of subjectivity inherent in such decisions is presented in the following paper. The model is specifically designed to expedite the decisionmaking process by providing a systematic approach for making these determination. In many cases, agencies may find that using this model can reduce the analysis and size of NEPA documents

Canonising the Hartle-Hawking proposal

International Nuclear Information System (INIS)

Louko, J.

1988-01-01

The canonical formulation of the Hartle-Hawking proposal is discussed in a class of spatially homogeneous minisuperspace models. Relying on arguments of consistency with the classical variational principle, we find a set of canonical variables in which the Hartle-Hawking boundary condition is abtained by fixing in the path integral the final values of the canonical coordinates but the initial values of the canonical momenta. A canonical measure of this kind offers a natural starting point for skeletonising the minisuperspace Hartle-Hawking path integral. (orig.)

76 FR 36566 - Notice of Submission of Proposed Information Collection to OMB “Logic Model” Grant Performance...

Science.gov (United States)

2011-06-22

... Proposed Information Collection to OMB ``Logic Model'' Grant Performance Report Standard AGENCY: Office of... lists the following information: Title of Proposal: ``Logic Model'' Grant Performance Report Standard. OMB Approval Number: 2535-0114. Form Numbers: HUD 96010, each program utilizing the Logic Model will...

Regulation of Th1 cells and experimental autoimmune encephalomyelitis (EAE) by glycogen synthase kinase-3

Science.gov (United States)

Beurel, Eléonore; Kaidanovich-Beilin, Oksana; Yeh, Wen-I; Song, Ling; Palomo, Valle; Michalek, Suzanne M.; Woodgett, James R.; Harrington, Laurie E.; Eldar-Finkelman, Hagit; Martinez, Ana; Jope, Richard S.

2013-01-01

Experimental autoimmune encephalomyelitis (EAE) is a rodent model of multiple sclerosis (MS), a debilitating autoimmune disease of the central nervous system, for which only limited therapeutic interventions are available. Since MS is mediated in part by autoreactive T cells, particularly Th17 and Th1 cells, in the present study, we tested if inhibitors of glycogen synthase kinase-3 (GSK3), previously reported to reduce Th17 cell generation, also alter Th1 cell production or ameliorate EAE. GSK3 inhibitors were found to impede the production of Th1 cells by reducing STAT1 activation. Molecularly reducing the expression of either of the two GSK3 isoforms demonstrated that Th17 cell production was sensitive to reduced levels of GSK3β, and Th1 cell production was inhibited in GSK3α-deficient cells. Administration of the selective GSK3 inhibitors TDZD-8, VP2.51, VP0.7, or L803-mts, significantly reduced the clinical symptoms of MOG35-55-induced EAE in mice, nearly eliminating the chronic progressive phase, and reduced the number of Th17 and Th1 cells in the spinal cord. Administration of TDZD-8 or L803-mts after the initial disease episode ameliorated clinical symptoms in a relapsing/remitting model of PLP139-151-induced EAE. Furthermore, deletion of GSK3β specifically in T cells was sufficient to ameliorate MOG35-55-induced EAE. These results demonstrate isoform-selective effects of GSK3 on T cell generation, therapeutic effects of GSK3 inhibitors in EAE, and that GSK3 inhibition in T cells is sufficient to reduce the severity of EAE, suggesting that GSK3 may be a feasible target for developing new therapeutic interventions for MS. PMID:23606540

Proposal of a model of system of identification for domestic animals: a comparison between brazilian and international laws

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Nicolau Cardoso Neto

2016-09-01

Full Text Available The relationship between humans and pets, especially dogs and cats is taking gigantic proportions, this can be seen by the data recently published by IBGE, where it was verified that the number of pets grows more than the number of child birth (IBGE, 2015. As so foreseen, the purpose of this study is to acknowledge which is the federal juridical basis related to the registration of Domestic Animals in Brazil, comparing them with the international legal standards that can be of reference, such as Canada, United States of America, Republic of Ireland and United Kingdom. This increase in pet population shows problems of many dimensions that relate to several causes in urban centers, especially when referring to zoonosis and conflicts that come from irresponsible ownership, bringing up a public health issue. The intension was to verify the possibility to adequate them to the reality encountered in Brazil, creating a model of identification for the Domestic Animals in urban areas in this country. As for that, the article addresses themes related to responsible ownership, animal welfare and models of registration already accomplished in the mentioned countries. At the end the article presents the proposal of a model for a system of identification of the Domestic Animals.

Leveraging ISI Multi-Model Prediction for Navy Operations: Proposal to the Office of Naval Research

Science.gov (United States)

2013-09-30

Operations: Proposal to the Office of Naval Research” PI: Benjamin Kirtman University of Miami – RSMAS Meteorology and Physical Oceanography...Prediction for Navy Operations: Proposal to the Office of Naval Research 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

Proposing a Metaliteracy Model to Redefine Information Literacy

Science.gov (United States)

Jacobson, Trudi E.; Mackey, Thomas P.

2013-01-01

Metaliteracy is envisioned as a comprehensive model for information literacy to advance critical thinking and reflection in social media, open learning settings, and online communities. At this critical time in higher education, an expansion of the original definition of information literacy is required to include the interactive production and…

A proposal for a typology of sharing economy

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Maira Petrini

2017-10-01

Full Text Available Purpose: to propose a typology for sharing economy that allows the characterization and classification of its main forms of manifestation. Originality/value: the theme that involves collaborative consumption and sharing economy has wide definitions with no clear establishment of boundaries between them. Part of that definition gap may occur because of the recent emergency of literature on sharing economy. Additionally, the fact that sharing economy and collaborative consumption are the newest buzzwords, several businesses started calling themselves as such. Design/methodology/approach: from the review of the literature, 11 characteristics that describe the theme were identified. In the light of those characteristics, 72 collaborative consumption websites were analyzed, representatives of the 24 collaborative consumption categories proposed by Botsman and Rogers (2010. Findings: three archetypes were identified: 1. new business models represent the new players based on technological platforms, which are the core business of the company, and generate income by charging service fees; 2. redesigned businesses are traditional market models redesigned to present time and price advantages to the consumer; 3. sharing by ideal is the archetype that best represents sustainable consumption alternative models.

[Proposed difficult airway teaching methodology. Presentation of an interactive fresh frozen cadaver model].

Science.gov (United States)

Catalá Bauset, J C; de Andres Ibañez, J A; Valverde Navarro, A; Martinez Soriano, F

2014-04-01

The aim of this paper is to present a methodology based on the use of fresh-frozen cadavers for training in the management of the airway, and to evaluate the degree of satisfaction among learning physicians. About 6 fresh-frozen cadavers and 14 workstations were prepared where participants were trained in the different skills needed for airway management. The details of preparation of the cadavers are described. The level of satisfaction of the participant was determined using a Likert rating scale of 5 points, at each of the 14 stations, as well as the overall assessment and clinical usefulness of the course. The mean overall evaluation of the course and its usefulness was 4.75 and 4.9, out of 5, respectively. All parts of the course were rated above 4 out of 5. The high level of satisfaction of the course remained homogeneous in the 2 editions analysed. The overall satisfaction of the course was not finally and uniquely determined by any of its particular parts. The fresh cadaver model for training physicians in techniques of airway management is a proposal satisfactory to the participant, and with a realism that approaches the live patient. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

The Brazilian Unified National Health System: Proposal of a Cost-effectiveness Evaluation Model

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Lilian Ribeiro de Oliveira

2016-04-01

Full Text Available The Brazilian Unified National Health System (Sistema Único de Saúde [SUS] is in a prominent position compared to the existing social policies. One of the new tools used by SUS is known as Performance Index of the Unified Health System (Índice de Desempenho do Sistema Único de Saúde [IDSUS], which is intended to measure the performance of each municipality. Therefore, the aim of this study was to propose a model of cost-effectiveness to compare IDSUS performance against total revenues achieved in Homogeneous Group 2, consisting of 94 municipalities and analysed using data from IDSUS and the System Information of the Public Budget for Health Care (Sistema de Informação do Orçamento Público em Saúde [SIOPS] for the year 2011. After structuring this data, we carried out descriptive statistical and cluster analysis in order to group similar municipalities in accordance with established variables: IDSUS performance, population and total revenue in health per capita. Even with the division of municipalities into homogeneous groups and after using variables such as population and revenue to regroup them, the results showed there are municipalities with heterogeneous characteristics. Another finding is in the use and intersection of two distinct databases (IDSUS and SIOPS, which allowed for visualizing the impact of health care revenue on the municipalities performance.

A new proposal for greenhouse gas emissions responsibility allocation: best available technologies approach.

Science.gov (United States)

Berzosa, Álvaro; Barandica, Jesús M; Fernández-Sánchez, Gonzalo

2014-01-01

In recent years, several methodologies have been developed for the quantification of greenhouse gas (GHG) emissions. However, determining who is responsible for these emissions is also quite challenging. The most common approach is to assign emissions to the producer (based on the Kyoto Protocol), but proposals also exist for its allocation to the consumer (based on an ecological footprint perspective) and for a hybrid approach called shared responsibility. In this study, the existing proposals and standards regarding the allocation of GHG emissions responsibilities are analyzed, focusing on their main advantages and problems. A new model of shared responsibility that overcomes some of the existing problems is also proposed. This model is based on applying the best available technologies (BATs). This new approach allocates the responsibility between the producers and the final consumers based on the real capacity of each agent to reduce emissions. The proposed approach is demonstrated using a simple case study of a 4-step life cycle of ammonia nitrate (AN) fertilizer production. The proposed model has the characteristics that the standards and publications for assignment of GHG emissions responsibilities demand. This study presents a new way to assign responsibilities that pushes all the actors in the production chain, including consumers, to reduce pollution. © 2013 SETAC.

Modern proposal of methodology for retrieval of characteristic synthetic rainfall hyetographs

Science.gov (United States)

Licznar, Paweł; Burszta-Adamiak, Ewa; Łomotowski, Janusz; Stańczyk, Justyna

2017-11-01

Modern engineering workshop of designing and modelling complex drainage systems is based on hydrodynamic modelling and has a probabilistic character. Its practical application requires a change regarding rainfall models accepted at the input. Previously used artificial rainfall models of simplified form, e.g. block precipitation or Euler's type II model rainfall are no longer sufficient. It is noticeable that urgent clarification is needed as regards the methodology of standardized rainfall hyetographs that would take into consideration the specifics of local storm rainfall temporal dynamics. The aim of the paper is to present a proposal for innovative methodology for determining standardized rainfall hyetographs, based on statistical processing of the collection of actual local precipitation characteristics. Proposed methodology is based on the classification of standardized rainfall hyetographs with the use of cluster analysis. Its application is presented on the example of selected rain gauges localized in Poland. Synthetic rainfall hyetographs achieved as a final result may be used for hydrodynamic modelling of sewerage systems, including probabilistic detection of necessary capacity of retention reservoirs.

The Effectiveness Evaluation among Different Player-Matching Mechanisms in a Multi-Player Quiz Game

Science.gov (United States)

Tsai, Fu-Hsing

2016-01-01

This study aims to investigate whether different player-matching mechanisms in educational multi-player online games (MOGs) can affect students' learning performance, enjoyment perception and gaming behaviors. Based on the multi-player quiz game, TRIS-Q, developed by Tsai, Tsai and Lin (2015) using a free player-matching (FPM) mechanism, the same…

"Minecraft," Teachers, Parents, and Learning: What They Need to Know and Understand

Science.gov (United States)

Ellison, Tisha Lewis; Evans, Jessica N.

2016-01-01

This article explores six effective principles for teachers to use to understand and apply "Minecraft" in today's classrooms. Video games have become one of the fastest growing forms of media for youth and adult consumers. "Minecraft," a multiplayer online game (MOG), is one of the most popular video games to date. By allowing…

Phosphorus-Based Dendrimer ABP Treats Neuroinflammation by Promoting IL-10-Producing CD4(+) T Cells.

Science.gov (United States)

Hayder, Myriam; Varilh, Marjorie; Turrin, Cédric-Olivier; Saoudi, Abdelhadi; Caminade, Anne-Marie; Poupot, Rémy; Liblau, Roland S

2015-11-09

Dendrimers are polyfunctional nano-objects of perfectly defined structure that can provide innovative alternatives for the treatment of chronic inflammatory diseases, including multiple sclerosis (MS). To investigate the efficiency of a recently described amino-bis(methylene phosphonate)-capped ABP dendrimer as a potential drug candidate for MS, we used the classical mouse model of MOG35-55-induced experimental autoimmune encephalomyelitis (EAE). Our study provides evidence that the ABP dendrimer prevents the development of EAE and inhibits the progression of established disease with a comparable therapeutic benefit as the approved treatment Fingolimod. We also show that the ABP dendrimer redirects the pathogenic myelin-specific CD4(+) T cell response toward IL-10 production.

Intercultural Education and Migration: Educational Proposals

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Pedro Ortega Ruiz

2011-01-01

Full Text Available This paper tackles the difficult problem that immigration poses for developed Western European societies and the need of a new model of intercultural education which puts the emphasis of educational activity not so much on “intellectual understanding” as on the acceptance and welcoming of the person who is different, on account of his/her culture or ethnic group. Educational proposals are put forward that are materialized in a change of the intercultural education model, the involvement of the family and of society in changing attitudes towards immigrants, the need not to attribute a metahistorical or essentialist meaning to cultural identity, and the restoring of an ethical and political dimension of educational activity.

A proposal to manage multi-task dialogs in conversational interfaces

Directory of Open Access Journals (Sweden)

David GRIOL

2016-11-01

Full Text Available The emergence of smart devices and recent advances in spoken language technology are currently extending the use of conversational interfaces and spoken interaction to perform many tasks. The dialog management task of a conversational interface consists of selecting the next system response considering the user's actions, the dialog history, and the results of accessing the data repositories. In this paper we describe a dialog management technique adapted to multi-task conversational systems. In our proposal, specialized dialog models are used to deal with each specific subtask of dialog objective for which the dialog system has been designed. The practical application of the proposed technique to develop a dialog system acting as a customer support service shows that the use of these specialized dialog models increases the quality and number of successful interactions with the system in comparison with developing a single dialog model.

Search for Hidden Particles (SHiP): a new experiment proposal

Science.gov (United States)

De Lellis, G.

2015-06-01

Searches for new physics with accelerators are being performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. We propose a new experimental facility meant to search for very weakly coupled particles in the few GeV mass domain. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored from the experimental point of view. A beam dump facility, built at CERN in the north area, using 400 GeV protons is a copious factory of charmed hadrons and could be used to probe the existence of such particles. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. In particular, tau anti-neutrinos have not been observed so far. We therefore propose an experiment to search for hidden particles and study tau neutrino physics at the same time.

Computerized analysis of the 12-lead electrocardiogram to identify epicardial ventricular tachycardia exit sites.

Science.gov (United States)

Yokokawa, Miki; Jung, Dae Yon; Joseph, Kim K; Hero, Alfred O; Morady, Fred; Bogun, Frank

2014-11-01

Twelve-lead electrocardiogram (ECG) criteria for epicardial ventricular tachycardia (VT) origins have been described. In patients with structural heart disease, the ability to predict an epicardial origin based on QRS morphology is limited and has been investigated only for limited regions in the heart. The purpose of this study was to determine whether a computerized algorithm is able to accurately differentiate epicardial vs endocardial origins of ventricular arrhythmias. Endocardial and epicardial pace-mapping were performed in 43 patients at 3277 sites. The 12-lead ECGs were digitized and analyzed using a mixture of gaussian model (MoG) to assess whether the algorithm was able to identify an epicardial vs endocardial origin of the paced rhythm. The MoG computerized algorithm was compared to algorithms published in prior reports. The computerized algorithm correctly differentiated epicardial vs endocardial pacing sites for 80% of the sites compared to an accuracy of 42% to 66% of other described criteria. The accuracy was higher in patients without structural heart disease than in those with structural heart disease (94% vs 80%, P = .0004) and for right bundle branch block (82%) compared to left bundle branch block morphologies (79%, P = .001). Validation studies showed the accuracy for VT exit sites to be 84%. A computerized algorithm was able to accurately differentiate the majority of epicardial vs endocardial pace-mapping sites. The algorithm is not region specific and performed best in patients without structural heart disease and with VTs having a right bundle branch block morphology. Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Quetiapine, an atypical antipsychotic, is protective against autoimmune-mediated demyelination by inhibiting effector T cell proliferation.

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Feng Mei

Full Text Available Quetiapine (Que, a commonly used atypical antipsychotic drug (APD, can prevent myelin from breakdown without immune attack. Multiple sclerosis (MS, an autoimmune reactive inflammation demyelinating disease, is triggered by activated myelin-specific T lymphocytes (T cells. In this study, we investigated the potential efficacy of Que as an immune-modulating therapeutic agent for experimental autoimmune encephalomyelitis (EAE, a mouse model for MS. Que treatment was initiated on the onset of MOG(35-55 peptide induced EAE mice and the efficacy of Que on modulating the immune response was determined by Flow Cytometry through analyzing CD4(+/CD8(+ populations and the proliferation of effector T cells (CD4(+CD25(- in peripheral immune organs. Our results show that Que dramatically attenuates the severity of EAE symptoms. Que treatment decreases the extent of CD4(+/CD8(+ T cell infiltration into the spinal cord and suppresses local glial activation, thereby diminishing the loss of mature oligodendrocytes and myelin breakdown in the spinal cord of EAE mice. Our results further demonstrate that Que treatment decreases the CD4(+/CD8(+ T cell populations in lymph nodes and spleens of EAE mice and inhibits either MOG(35-55 or anti-CD3 induced proliferation as well as IL-2 production of effector T cells (CD4(+CD25(- isolated from EAE mice spleen. Together, these findings suggest that Que displays an immune-modulating role during the course of EAE, and thus may be a promising candidate for treatment of MS.

Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein.

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Marita Bosticardo

Full Text Available Wiskott-Aldrich Syndrome protein (WASP is a key regulator of the actin cytoskeleton in hematopoietic cells. Defective expression of WASP leads to multiple abnormalities in different hematopoietic cells. Despite severe impairment of T cell function, WAS patients exhibit a high prevalence of autoimmune disorders. We attempted to induce EAE, an animal model of organ-specific autoimmunity affecting the CNS that mimics human MS, in Was(-/- mice. We describe here that Was(-/- mice are markedly resistant against EAE, showing lower incidence and milder score, reduced CNS inflammation and demyelination as compared to WT mice. Microglia was only poorly activated in Was(-/- mice. Antigen-induced T-cell proliferation, Th-1 and -17 cytokine production and integrin-dependent adhesion were increased in Was(-/- mice. However, adoptive transfer of MOG-activated T cells from Was(-/- mice in WT mice failed to induce EAE. Was(-/- mice were resistant against EAE also when induced by adoptive transfer of MOG-activated T cells from WT mice. Was(+/- heterozygous mice developed an intermediate clinical phenotype between WT and Was(-/- mice, and they displayed a mixed population of WASP-positive and -negative T cells in the periphery but not in their CNS parenchyma, where the large majority of inflammatory cells expressed WASP. In conclusion, in absence of WASP, T-cell responses against a CNS autoantigen are increased, but the ability of autoreactive T cells to induce CNS autoimmunity is impaired, most probably because of an inefficient T-cell transmigration into the CNS and defective CNS resident microglial function.

Modeling of Communication in a Computational Situation Assessment Model

International Nuclear Information System (INIS)

Lee, Hyun Chul; Seong, Poong Hyun

2009-01-01

Operators in nuclear power plants have to acquire information from human system interfaces (HSIs) and the environment in order to create, update, and confirm their understanding of a plant state, or situation awareness, because failures of situation assessment may result in wrong decisions for process control and finally errors of commission in nuclear power plants. Quantitative or prescriptive models to predict operator's situation assessment in a situation, the results of situation assessment, provide many benefits such as HSI design solutions, human performance data, and human reliability. Unfortunately, a few computational situation assessment models for NPP operators have been proposed and those insufficiently embed human cognitive characteristics. Thus we proposed a new computational situation assessment model of nuclear power plant operators. The proposed model incorporating significant cognitive factors uses a Bayesian belief network (BBN) as model architecture. It is believed that communication between nuclear power plant operators affects operators' situation assessment and its result, situation awareness. We tried to verify that the proposed model represent the effects of communication on situation assessment. As the result, the proposed model succeeded in representing the operators' behavior and this paper shows the details

“Sweet Science:” A Proposal for Integral Macropolitics

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Daniel Gustav Anderson

2010-03-01

Full Text Available This treatise proposes the practice of becoming-responsible as a basis for integral micropolitics, defined as taking active responsibility for the well-being of the totality of living beings without exception, for the sake of that well-being alone. After reviewing two extant integral models for political action and interaction, demonstrating some of the limitations inherent in them, some ways are outlined in which the characteristic features of becoming-responsible—including critical clarity, compassion, competence, and consciousness—can be expressed in the realm of public concern; first, theoretically, drawing on a model proposed by poet and artist William Blake, and second, also historically, reflecting on an experiment in radical democracy in Chile (1970-1973, such that both examples critique and advance the claims and methods of mainstream integral theory as well as the alternative approach elaborated in this essay.

Integrated model of biopurification system for home sewage. A proposal for peri-urban communities from south center of Chile

International Nuclear Information System (INIS)

Parra Pierart, Izaul; Chiang Rojas, Gustavo

2013-01-01

The rapid growth of world population and its impacts has led to search new sources of water supply. Wastewater constitutes an additional source to satisfy the demand of this resource. Diverse researchers have designed alternatives for improve its processing and promote its utilization. This study examines some alternatives of bio-purification and proposes a conceptual design of a hybrid system that combines the use of a bio filter with artificial wetlands. The model designed contributes to improve water resources management and has educational, landscape and environmental benefits for peri-urban communities. Besides constitutes an alternative to promote more efficiently natural resources management at the local level.

Endogenous adaptation to low oxygen modulates T-cell regulatory pathways in EAE.

Science.gov (United States)

Esen, Nilufer; Katyshev, Vladimir; Serkin, Zakhar; Katysheva, Svetlana; Dore-Duffy, Paula

2016-01-19

In the brain, chronic inflammatory activity may lead to compromised delivery of oxygen and glucose suggesting that therapeutic approaches aimed at restoring metabolic balance may be useful. In vivo exposure to chronic mild normobaric hypoxia (10 % oxygen) leads to a number of endogenous adaptations that includes vascular remodeling (angioplasticity). Angioplasticity promotes tissue survival. We have previously shown that induction of adaptive angioplasticity modulates the disease pattern in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE). In the present study, we define mechanisms by which adaptation to low oxygen functionally ameliorates the signs and symptoms of EAE and for the first time show that tissue hypoxia may fundamentally alter neurodegenerative disease. C57BL/6 mice were immunized with MOG, and some of them were kept in the hypoxia chambers (day 0) and exposed to 10 % oxygen for 3 weeks, while the others were kept at normoxic environment. Sham-immunized controls were included in both hypoxic and normoxic groups. Animals were sacrificed at pre-clinical and peak disease periods for tissue collection and analysis. Exposure to mild hypoxia decreased histological evidence of inflammation. Decreased numbers of cluster of differentiation (CD)4+ T cells were found in the hypoxic spinal cords associated with a delayed Th17-specific cytokine response. Hypoxia-induced changes did not alter the sensitization of peripheral T cells to the MOG peptide. Exposure to mild hypoxia induced significant increases in anti-inflammatory IL-10 levels and an increase in the number of spinal cord CD25+FoxP3+ T-regulatory cells. Acclimatization to mild hypoxia incites a number of endogenous adaptations that induces an anti-inflammatory milieu. Further understanding of these mechanisms system may pinpoint possible new therapeutic targets to treat neurodegenerative disease.

On Basu's proposal: Fines affect bribes

OpenAIRE

Popov, Sergey V.

2017-01-01

I model the connection between the equilibrium bribe amount and the fines imposed on both bribe-taker and bribe-payer. I show that Basu's (2011) proposal to lower the fines imposed on bribe-payers in order to induce more whistleblowing and increase the probability of penalizing corrupt government officials might instead increase bribe amounts. Higher expected fines on bribe-takers will make them charge larger bribes; at the same time, lowering fines for bribe-paying might increase bribe-payer...

Proposed Sources of Coaching Efficacy: A Meta-Analysis.

Science.gov (United States)

Myers, Nicholas D; Park, Sung Eun; Ahn, Soyeon; Lee, Seungmin; Sullivan, Philip J; Feltz, Deborah L

2017-08-01

Coaching efficacy refers to the extent to which a coach believes that he or she has the capacity to affect the learning and performance of his or her athletes. The purpose of the current study was to empirically synthesize findings across the extant literature to estimate relationships between the proposed sources of coaching efficacy and each of the dimensions of coaching efficacy. A literature search yielded 20 studies and 278 effect size estimates that met the inclusion criteria. The overall relationship between the proposed sources of coaching efficacy and each dimension of coaching efficacy was positive and ranged from small to medium in size. Coach gender and level coached moderated the overall relationship between the proposed sources of coaching efficacy and each of the dimensions of coaching efficacy. Results from this meta-analysis provided some evidence for both the utility of, and possible revisions to, the conceptual model of coaching efficacy.

Comparative Analysis of Three Proposed Federal Renewable Electricity Standards

Energy Technology Data Exchange (ETDEWEB)

Sullivan, P.; Logan, J.; Bird, L.; Short, W.

2009-05-01

This paper analyzes potential impacts of proposed national renewable electricity standard (RES) legislation. An RES is a mandate requiring certain electricity retailers to provide a minimum share of their electricity sales from qualifying renewable power generation. The analysis focuses on draft bills introduced individually by Senator Jeff Bingaman and Representative Edward Markey, and jointly by Representative Henry Waxman and Markey. The analysis uses NREL's Regional Energy Deployment System (ReEDS) model to evaluate the impacts of the proposed RES requirements on the U.S. energy sector in four scenarios.

A proposal for standardizing computed tomography reports on abdominal aortic aneurysms

International Nuclear Information System (INIS)

Torlai, Fabiola Goda; Meirelles, Gustavo S. Portes; Miranda Junior, Fausto; Fonseca, Jose Honorio A.P. da; Ajzen, Sergio; D'Ippolito, Giuseppe

2006-01-01

Objective: to propose a model to standardize computed tomography reports on abdominal aortic aneurysms. Materials and methods: interviews were carried out with members of the Vascular Surgery Division of our institution, in the period between April and October 2004, aiming at developing a standardized model of computed tomography reports on abdominal aortic aneurysms. Based on this model, a questionnaire was elaborated and sent to other nine surgeons, all of them experienced in the field of abdominal aortic surgery. The questionnaires response rate was 55.5% (5/9). Results: the most frequently mentioned parameters of interest for evaluation of abdominal aortic aneurysms were: maximum diameter of proximal aortic neck, proximal aortic neck length to lower renal arteries, shape of proximal aortic neck, maximum diameter of the aneurysm and diameter of the common iliac arteries. These data allowed the development of a proposal for a model to standardize computed tomography reports. Conclusion: a model for standardized tomographic analysis of abdominal aortic aneurysms has met vascular surgeons' needs for following-up patients and planning their treatment. (author)

A Model Proposal on the Use of Creative Tourism Experiences in Congress Tourism and the Congress Marketing Mix

Directory of Open Access Journals (Sweden)

Özen Kırant Yozcu

2010-04-01

Full Text Available Congress tourism has a great importance for the extension of the tourism season, enhancement of employment opportunities and tourism revenues, promotion and efficient use of the facilities in the area. Creative Tourism provides an authentic feel for a local culture through informal, hands-on workshops and creative experiences. Ensuring that the attendants of congress tourism take part in creative tourism activities may be an example of the synergy to be achieved by including creative tourism in thecongress marketing mix. In this study the tourism marketing mix, programming, packaging, partnership, people, product, price, promotion, place, are adapted for congress tourism and a model which illustrates how to use the creative tourism experiences and activities within the marketing mix is proposed.

Autoantibodies in patients with neuromyelitis optica

Directory of Open Access Journals (Sweden)

Xin FAN

2016-10-01

Full Text Available Neuromyelitis optica (NMO is an autoimmune disease of the central nervous system (CNS which primarily involves the optic nerve and spinal cord. Aquaporin 4 (AQP4 is the main objective antigen, and its specific antibody was NMO-IgG. It was found in clinic that most of NMO-IgG-positive patients were female, whose clinical symptoms were more severe, bilateral optic neuritis (BON or optic neuritis (ON and myelitis were more likely to appear at the same time, and involved spinal segments were longer. Recent studies discovered that anti-aquaporin 1 (AQP1 and anti-myelin oligodendrocyte glycoprotein (MOG antibodies existed in the serum of patients with NMO-IgG-negative. It was discovered that low proportions of women, more cases of long-segment spinal cord lesion, and rare cases of ON appeared in anti-AQP1 antibody-positive patients. Most of anti-MOG antibody-positive patients were male. ON was common, especially bilateral optic nerves involved at the same time, and thoracolumbar involvement was common. DOI: 10.3969/j.issn.1672-6731.2016.10.004

Traversable braneworld wormholes supported by astrophysical observations

Science.gov (United States)

Wang, Deng; Meng, Xin-He

2018-02-01

In this study, we investigate the characteristics and properties of a traversable wormhole constrained by the current astrophysical observations in the framework of modified theories of gravity (MOG). As a concrete case, we study traversable wormhole space-time configurations in the Dvali-Gabadadze-Porrati (DGP) braneworld scenario, which are supported by the effects of the gravity leakage of extra dimensions. We find that the wormhole space-time structure will open in terms of the 2 σ confidence level when we utilize the joint constraints supernovae (SNe) Ia + observational Hubble parameter data (OHD) + Planck + gravitational wave (GW) and z based on various energy conditions; (ii) we can offer a strict restriction to the local wormhole space-time structure by using the current astrophysical observations; and (iii) we can clearly identify a physical gravitational resource for the wormholes supported by astrophysical observations, namely the dark energy components of the universe or equivalent space-time curvature effects from MOG. Moreover, we find that the strong energy condition is always violated at low redshifts.

Assessing the EC ILUC proposal. Dutch national ILUC Impact Assessment

Energy Technology Data Exchange (ETDEWEB)

Peters, D.; Toop, G.; Van den Bos, A.; Spoettle, M.

2013-04-15

Indirect Land Use Change (ILUC) is the effect that when existing agricultural land producing food is used for biofuel feedstock production, food production is reduced and this reduction is partially compensated by the conversion of non-agricultural land into new cropland elsewhere. ILUC can have a negative impact on the GHG performance of biofuels and can lead to loss of biodiversity. ILUC, its quantification and possible policy measures have been debated in the EU since 2008. The final legislative text to be negotiated on the basis of the ILUC proposal is likely to have a profound impact on the current EU biofuels market but especially on its future development. This report assesses the legal soundness and factual basis of the proposal. It also assesses the policy risks, effectiveness of, and economic consequences resulting from the four most important proposed measures. Alternative scenarios are explored for each of the proposed measures. The report starts with a description of the Dutch biofuels market as the current situation and future perspective of this market is naturally of specific concern for Dutch negotiators in Brussels. This report takes the IFPRI (International Food Policy Research Institute) 2011 modelling study as a starting point when assessing the ILUC impacts of EU biofuels. The IFPRI study modelling results assign high ILUC emissions to conventional biodiesel and assigns much lower ILUC emissions to conventional ethanol. The study does not model ILUC effects of advanced biofuels. The Dutch biofuels market is dominated by biodiesel, of which a large share is double counting. Following the IFPRI 2011 ILUC modelling, this means that a high share of biofuels with a high ILUC risk are supplied to the market but also a high share of advanced, double counting biofuels with a low to medium ILUC risk. The Netherlands hosts a relatively large oilseed crushing and biofuel production industry, of which an important share consists of advanced biofuel

Some proposed mechanisms for internal cladding corrosion

International Nuclear Information System (INIS)

Bradbury, M.H.; Pickering, S.; Whitlow, W.H.

1977-01-01

In spite of extensive research during recent years, a comprehensive model for internal cladding corrosion in fast reactor oxide fuel pins has not yet been established. In this paper, a model is proposed which accounts for many of the features normally associated with this type of corrosion. The model is composed of a number of parts which describe the chronological sequence of events at the fuel/cladding interface. The corrosion reaction is visualised as being primarily chemical in character, involving the cladding steel, the fuel and the more aggressive fission products, notably caesium in the presence of oxygen. The model attempts to explain how corrosion starts, how it depends on the oxygen potential, why it occurs non-uniformly; also covered are phase changes within the cladding steel and morphological features such as the intergranular form of attack and the distribution of corrosion products in the fuel/cladding gap. (author)

Some proposed mechanisms for internal cladding corrosion

Energy Technology Data Exchange (ETDEWEB)

Bradbury, M H; Pickering, S; Whitlow, W H [EURATOM (United Kingdom)

1977-04-01

In spite of extensive research during recent years, a comprehensive model for internal cladding corrosion in fast reactor oxide fuel pins has not yet been established. In this paper, a model is proposed which accounts for many of the features normally associated with this type of corrosion. The model is composed of a number of parts which describe the chronological sequence of events at the fuel/cladding interface. The corrosion reaction is visualised as being primarily chemical in character, involving the cladding steel, the fuel and the more aggressive fission products, notably caesium in the presence of oxygen. The model attempts to explain how corrosion starts, how it depends on the oxygen potential, why it occurs non-uniformly; also covered are phase changes within the cladding steel and morphological features such as the intergranular form of attack and the distribution of corrosion products in the fuel/cladding gap. (author)

Different Mechanisms of Inflammation Induced in Virus and Autoimmune-Mediated Models of Multiple Sclerosis in C57BL6 Mice

Directory of Open Access Journals (Sweden)

Abhinoy Kishore

2013-01-01

Full Text Available Multiple sclerosis (MS is an inflammatory demyelinating disease of the human central nervous system (CNS. Neurotropic demyelinating strain of MHV (MHV-A59 or its isogenic recombinant strain RSA59 induces MS-like disease in mice mediated by microglia, along with a small population of T cells. The mechanism of demyelination is at least in part due to microglia-mediated myelin stripping, with some direct axonal injury. Immunization with myelin oligodendrocyte glycoprotein (MOG induces experimental autoimmune encephalomyelitis (EAE, a mainly CD4+ T-cell-mediated disease, although CD8+ T cells may play a significant role in demyelination. It is possible that both autoimmune and nonimmune mechanisms such as direct viral toxicity may induce MS. Our study directly compares CNS pathology in autoimmune and viral-induced MS models. Mice with viral-induced and EAE demyelinating diseases demonstrated similar patterns and distributions of demyelination that accumulated over the course of the disease. However, significant differences in acute inflammation were noted. Inflammation was restricted mainly to white matter at all times in EAE, whereas inflammation initially largely involved gray matter in acute MHV-induced disease and then is subsequently localized only in white matter in the chronic disease phase. The presence of dual mechanisms of demyelination may be responsible for the failure of immunosuppression to promote long-term remission in many MS patients.

77 FR 28655 - Notice of Order Soliciting Community Proposals

Science.gov (United States)

2012-05-15

..., including business, educational institutions, and other enterprises, whose access to the national air... tourism); whether the proposed project, if successfully implemented, could serve as a working model for... responsible for developing, implementing, and managing activities related to the air service development zone...

Proposed Hydro-Quebec development plan, 1993: Proposal

International Nuclear Information System (INIS)

1992-01-01

The Quebec government now requires Hydro-Quebec to submit a development plan every three years instead of annually, in order to permit more in-depth studies and a broader consultation with interested parties. In the first of such three-year plans, a series of plan proposals is presented which was developed after a year of consultation with various groups on four fundamental matters: energy efficiency, means of generation, electro-intensive industries, and electricity exports. Options for meeting future demand at Hydro-Quebec are assessed, including the construction of new generation and transmission facilities, rehabilitation of existing facilities, improving electrical energy efficiency, and conservation strategies. These options are considered while applying the principle of sustainable development that respects the environment. Hydroelectricity will continue to be emphasized as the main source of generation since hydroelectric facilities offer distinct advantages in terms of costs, environmental impacts, and economic spinoffs. The proposed plan also presents objectives and strategies for improving the quality of service and internal operations. Financial forecasts for Hydro-Quebec are proposed which take into account the forecast changes in the utility's cost and revenue factors and its self-financing requirements. 5 figs., 15 tabs

Proposed improvements to a model for characterizing the electrical and thermal energy performance of stirling engine micro-cogeneration devices based upon experimental observations

Energy Technology Data Exchange (ETDEWEB)

Lombardi, K. [CanmetENERGY, 1 Haanel Drive, Ottawa, Ont. (Canada); Ugursal, V.I. [Dalhousie University, Halifax, NS (Canada); Beausoleil-Morrison, I. [Carleton University, 1125 Colonel By Drive, Ottawa, Ont. (Canada)

2010-10-15

Stirling engines (SE) are a market-ready technology suitable for residential cogeneration of heat and electricity to alleviate the increasing demand on central power grids. Advantages of this external combustion engine include high cogeneration efficiency, fuel flexibility, low noise and vibration, and low emissions. To explore and assess the feasibility of using SE based cogeneration systems in the residential sector, there is a need for an accurate and practical simulation model that can be used to conduct sensitivity and what-if analyses. A simulation model for SE based residential scale micro-cogeneration systems was recently developed; however the model is impractical due to its functional form and data requirements. Furthermore, the available experimental data lack adequate diversity to assess the model's suitability. In this paper, first the existing model is briefly presented, followed by a review of the design and implementation of a series of experiments conducted to study the performance and behaviour of the SE system and to develop extensive, and hitherto unavailable, operational data. The empirical observations are contrasted with the functional form of the existing simulation model, and improvements to the structure of the model are proposed based upon these observations. (author)

Proposal of performance indicators/model for Operational Readiness Verification (ORV) at restart after a planned shutdown; Framtagning av bedoemningsfaktorer/modell foer utvaerdering av driftklarhetsverifiering (DKV) infoer uppstart efter revisionsavstaellning

Energy Technology Data Exchange (ETDEWEB)

Hollnagel, Erik; Nygren, Magnus [Linkoeping Univ. (Sweden). Dept. of Computer and Information Science

2005-12-15

The objectives of the study reported here were to propose a model that can be used in the analysis of possible future ORV-related events and to outline a set of performance indicators that can be used by the inspectorate to assess a utility's level of readiness if an ORV-event should take place. Together the two objectives serve to improve the inspectorate's ability to ensure that the utilities maintain an adequate capability to respond. The background for the current study is the nine ORV events that occurred in Sweden between 1995- 1998, as well as the findings of a previous study of safety during outage and restart of nuclear power plants project. This study found that the three levels or types of tests that occur in ORV were used according to need rather than according to a predefined arrangement or procedure, and that tasks were adapted relative to the different types of embedding and the degree of correspondence between nominal and actual ORV. The organisation's coping with the complexity of ORV was discussed by the relation between expectations and surprises, how planning was used as control, attention to details, and the practices of shift changes. It is a truism that accidents are analysed and interpreted relative to a commonly accepted understanding of their nature. This understanding is, however, relative rather than absolute, and has changed significantly during the last decade. In the 1990s, accidents were analysed step by step, and explanations and recommendations therefore emphasised specific rather than generic solutions. The present study illustrates this by going through the responses to the nine ORV events. Following that, the nine events are analysed anew using a contemporary understanding of accidents (a systemic model), which emphasises that incidents more often arise from context induced performance variability than from failures of people. The alternative interpretation provided by a systemic model is illustrated by a detailed

The qualitative research proposal

Directory of Open Access Journals (Sweden)

H Klopper

2008-09-01

Full Text Available Qualitative research in the health sciences has had to overcome many prejudices and a number of misunderstandings, but today qualitative research is as acceptable as quantitative research designs and is widely funded and published. Writing the proposal of a qualitative study, however, can be a challenging feat, due to the emergent nature of the qualitative research design and the description of the methodology as a process. Even today, many sub-standard proposals at post-graduate evaluation committees and application proposals to be considered for funding are still seen. This problem has led the researcher to develop a framework to guide the qualitative researcher in writing the proposal of a qualitative study based on the following research questions: (i What is the process of writing a qualitative research proposal? and (ii What does the structure and layout of a qualitative proposal look like? The purpose of this article is to discuss the process of writing the qualitative research proposal, as well as describe the structure and layout of a qualitative research proposal. The process of writing a qualitative research proposal is discussed with regards to the most important questions that need to be answered in your research proposal with consideration of the guidelines of being practical, being persuasive, making broader links, aiming for crystal clarity and planning before you write. While the structure of the qualitative research proposal is discussed with regards to the key sections of the proposal, namely the cover page, abstract, introduction, review of the literature, research problem and research questions, research purpose and objectives, research paradigm, research design, research method, ethical considerations, dissemination plan, budget and appendices.

Uvod v tematski sklop

Directory of Open Access Journals (Sweden)

Florence Gacoin-Marks

2009-12-01

Slovenski raziskovalni prostor seveda premore veliko več zanimivih raziskav v zvezi z Afriko, zato lahko samo obžalujemo, da nekateri raziskovalci pri tej publikaciji niso mogli sodelovati in da zato njihova stroka tukaj ni zastopana. Ob tej priložnosti se iskreno zahvaljujem vsem, ki so sodelovali pri projektu s kakovostnimi in raznovrstnimi razpravami.

2012 Community Earth System Model (CESM) Tutorial - Proposal to DOE

Energy Technology Data Exchange (ETDEWEB)

Holland, Marika [National Center for Atmospheric Research, Boulder, CO (United States); Bailey, David A [National Center for Atmospheric Research, Boulder, CO (United States)

2013-03-18

The Community Earth System Model (CESM) is a fully-coupled, global climate model that provides state-of-the-art computer simulations of the Earth's past, present, and future climate states. This document provides the agenda and list of participants for the conference. Web materials for all lectures and practical sessions available from: http://www.cesm.ucar.edu/events/tutorials/073012/ .

Mathematical Formalization Of Theories Of Motivation Proposed By Abraham Maslow And Frederick Herzberg

OpenAIRE

Ivan Kotliarov

2008-01-01

the present article gives an outline of a mathematical model of theories of motivation proposed by Abraham Maslow and Frederick Herzberg. This model is built on a basis of special non-continuous functions.

All Optical Measurement Proposed for the Photovoltaic Hall Effect

International Nuclear Information System (INIS)

Oka, Takashi; Aoki, Hideo

2011-01-01

We propose an all optical way to measure the recently proposed p hotovoltaic Hall effect , i.e., a Hall effect induced by a circularly polarized light in the absence of static magnetic fields. This is done in a pump-probe experiment with the Faraday rotation angle being the probe. The Floquet extended Kubo formula for photo-induced optical response is formulated and the ac-Hall conductivity is calculated. We also point out the possibility of observing the effect in two layered graphene, three-dimensional graphite, and more generally in multi-band systems such as materials described by the dp-model.

The respiratory tract deposition model proposed by the ICRP Task Group

International Nuclear Information System (INIS)

James, A.C.; Briant, J.K.; Stahlhofen, W.; Rudolf, G.; Gehr, P.

1990-11-01

The Task Group has developed a new model of the deposition of inhaled aerosols in each anatomical region of the respiratory tract. The model is used to evaluate the fraction of airborne activity that is deposited in respiratory regions having distinct retention characteristics and clearance pathways: the anterior nares, the extrathoracic airways of the naso- and oropharynx and larynx, the bronchi, the bronchioles, and the alveolated airways of the lung. Drawn from experimental data on total and regional deposition in human subjects, the model is based on extrapolation of these data by means of a detailed theoretical model of aerosol transport and deposition within the lung. The Task Group model applies to all practical conditions, and for aerosol particles and vapors from atomic size up to very coarse aerosols with an activity median aerodynamic diameter of 100 μm. The model is designed to predict regional deposition in different subjects, including adults of either sex, children of various ages, and infants, and also to account for anatomical differences among Caucasian and non-Caucasian subjects. The Task Group model represents aerosol inhalability and regional deposition in different subjects by algebraic expressions of aerosol size, breathing rates, standard lung volumes, and scaling factors for airway dimensions. 35 refs., 13 figs., 2 tabs

comparative analysis of some existing kinetic models with proposed

African Journals Online (AJOL)

IGNATIUS NWIDI

two statistical parameters namely; linear regression coefficient of correlation (R2) and ... Keynotes: Heavy metals, Biosorption, Kinetics Models, Comparative analysis, Average Relative Error. 1. ... If the flow rate is low, a simple manual batch.

a Proposed Benchmark Problem for Scatter Calculations in Radiographic Modelling

Science.gov (United States)

Jaenisch, G.-R.; Bellon, C.; Schumm, A.; Tabary, J.; Duvauchelle, Ph.

2009-03-01

Code Validation is a permanent concern in computer modelling, and has been addressed repeatedly in eddy current and ultrasonic modeling. A good benchmark problem is sufficiently simple to be taken into account by various codes without strong requirements on geometry representation capabilities, focuses on few or even a single aspect of the problem at hand to facilitate interpretation and to avoid that compound errors compensate themselves, yields a quantitative result and is experimentally accessible. In this paper we attempt to address code validation for one aspect of radiographic modeling, the scattered radiation prediction. Many NDT applications can not neglect scattered radiation, and the scatter calculation thus is important to faithfully simulate the inspection situation. Our benchmark problem covers the wall thickness range of 10 to 50 mm for single wall inspections, with energies ranging from 100 to 500 keV in the first stage, and up to 1 MeV with wall thicknesses up to 70 mm in the extended stage. A simple plate geometry is sufficient for this purpose, and the scatter data is compared on a photon level, without a film model, which allows for comparisons with reference codes like MCNP. We compare results of three Monte Carlo codes (McRay, Sindbad and Moderato) as well as an analytical first order scattering code (VXI), and confront them to results obtained with MCNP. The comparison with an analytical scatter model provides insights into the application domain where this kind of approach can successfully replace Monte-Carlo calculations.

Proposal and analysis of a high-efficiency combined desalination and refrigeration system based on the LiBr-H2O absorption cycle-Part 1: System configuration and mathematical model

International Nuclear Information System (INIS)

Wang Yongqing; Lior, Noam

2011-01-01

Simultaneous production of fresh water and refrigeration are often required, e.g. in warm-climate water-deficient regions, and this study is a proposal and analysis of an efficient way of producing both of them by consuming mainly low-grade heat. After introducing the configuration choice methodology, a combined refrigeration and water system, ARHP-MEE (absorption refrigeration heat pump and multi-effect evaporation desalter), which is the integration of a LiBr-H 2 O refrigeration unit, a LiBr-H 2 O heat pump, and a low-temperature multi-effect evaporation desalination unit, is proposed, and the mathematical model is presented and validated. The model serves for conducting a performance analysis of the combined system, reported in Part 2 of this two-part paper.

Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination

Directory of Open Access Journals (Sweden)

Honegger Paul

2009-05-01

Full Text Available Abstract Background Brain inflammation plays a central role in numerous brain pathologies, including multiple sclerosis (MS. Microglial cells and astrocytes are the effector cells of neuroinflammation. They can be activated also by agents such as interferon-γ (IFN-γ and lipopolysaccharide (LPS. Peroxisome proliferator-associated receptor (PPAR pathways are involved in the control of the inflammatory processes, and PPAR-β seems to play an important role in the regulation of central inflammation. In addition, PPAR-β agonists were shown to have trophic effects on oligodendrocytes in vitro, and to confer partial protection in experimental autoimmune encephalomyelitis (EAE, an animal model of MS. In the present work, a three-dimensional brain cell culture system was used as in vitro model to study antibody-induced demyelination and inflammatory responses. GW 501516, a specific PPAR-β agonist, was examined for its capacity to protect from antibody-mediated demyelination and to prevent inflammatory responses induced by IFN-γ and LPS. Methods Aggregating brain cells cultures were prepared from embryonal rat brain, and used to study the inflammatory responses triggered by IFN-γ and LPS and by antibody-mediated demyelination induced by antibodies directed against myelin-oligodendrocyte glycoprotein (MOG. The effects of GW 501516 on cellular responses were characterized by the quantification of the mRNA expression of tumor necrosis factor-α (TNF-α, interleukin-6 (IL-6, inducible NO synthase (i-NOS, PPAR-β, PPAR-γ, glial fibrillary acidic protein (GFAP, myelin basic protein (MBP, and high molecular weight neurofilament protein (NF-H. GFAP expression was also examined by immunocytochemistry, and microglial cells were visualized by isolectin B4 (IB4 and ED1 labeling. Results GW 501516 decreased the IFN-γ-induced up-regulation of TNF-α and iNOS in accord with the proposed anti-inflammatory effects of this PPAR-β agonist. However, it increased IL

A Proposed Conceptual Model to Measure Unwarranted Practice Variation

National Research Council Canada - National Science Library

Barr, Andrew M

2007-01-01

.... Employing a unit of analysis of the U.S. Army healthcare system and utilizing research by Wennberg and the Institute of Medicine, a model describing healthcare quality in terms of unwarranted practice variation and healthcare outcomes...

Proposing a Model of Co-Regulated Learning for Graduate Medical Education.

Science.gov (United States)

Rich, Jessica V

2017-08-01

Primarily grounded in Zimmerman's social cognitive model of self-regulation, graduate medical education is guided by principles that self-regulated learning takes place within social context and influence, and that the social context and physical environment reciprocally influence persons and their cognition, behavior, and development. However, contemporary perspectives on self-regulation are moving beyond Zimmerman's triadic reciprocal orientation to models that consider social transactions as the central core of regulated learning. Such co-regulated learning models emphasize shared control of learning and the role more advanced others play in scaffolding novices' metacognitive engagement.Models of co-regulated learning describe social transactions as periods of distributed regulation among individuals, which instrumentally promote or inhibit the capacity for individuals to independently self-regulate. Social transactions with other regulators, including attending physicians, more experienced residents, and allied health care professionals, are known to mediate residents' learning and to support or hamper the development of their self-regulated learning competence. Given that social transactions are at the heart of learning-oriented assessment and entrustment decisions, an appreciation for co-regulated learning is likely important for advancing medical education research and practice-especially given the momentum of new innovations such as entrustable professional activities.In this article, the author explains why graduate medical educators should consider adopting a model of co-regulated learning to complement and extend Zimmerman's models of self-regulated learning. In doing so, the author suggests a model of co-regulated learning and provides practical examples of how the model is relevant to graduate medical education research and practice.

Summary and synthesis: How to present a research proposal

Directory of Open Access Journals (Sweden)

Maninder Singh Setia

2017-01-01

Full Text Available This concluding module attempts to synthesize the key learning points discussed during the course of the previous ten sets of modules on methodology and biostatistics. The objective of this module is to discuss how to present a model research proposal, based on whatever was discussed in the preceding modules. The lynchpin of a research proposal is the protocol, and the key component of a protocol is the study design. However, one must not neglect the other areas, be it the project summary through which one catches the eyes of the reviewer of the proposal, or the background and the literature review, or the aims and objectives of the study. Two critical areas in the “methods” section that cannot be emphasized more are the sampling strategy and a formal estimation of sample size. Without a legitimate sample size, none of the conclusions based on the statistical analysis would be valid. Finally, the ethical parameters of the study should be well understood by the researchers, and that should get reflected in the proposal.

Summary and Synthesis: How to Present a Research Proposal.

Science.gov (United States)

Setia, Maninder Singh; Panda, Saumya

2017-01-01

This concluding module attempts to synthesize the key learning points discussed during the course of the previous ten sets of modules on methodology and biostatistics. The objective of this module is to discuss how to present a model research proposal, based on whatever was discussed in the preceding modules. The lynchpin of a research proposal is the protocol, and the key component of a protocol is the study design. However, one must not neglect the other areas, be it the project summary through which one catches the eyes of the reviewer of the proposal, or the background and the literature review, or the aims and objectives of the study. Two critical areas in the "methods" section that cannot be emphasized more are the sampling strategy and a formal estimation of sample size. Without a legitimate sample size, none of the conclusions based on the statistical analysis would be valid. Finally, the ethical parameters of the study should be well understood by the researchers, and that should get reflected in the proposal.

Generating region proposals for histopathological whole slide image retrieval.

Science.gov (United States)

Ma, Yibing; Jiang, Zhiguo; Zhang, Haopeng; Xie, Fengying; Zheng, Yushan; Shi, Huaqiang; Zhao, Yu; Shi, Jun

2018-06-01

Content-based image retrieval is an effective method for histopathological image analysis. However, given a database of huge whole slide images (WSIs), acquiring appropriate region-of-interests (ROIs) for training is significant and difficult. Moreover, histopathological images can only be annotated by pathologists, resulting in the lack of labeling information. Therefore, it is an important and challenging task to generate ROIs from WSI and retrieve image with few labels. This paper presents a novel unsupervised region proposing method for histopathological WSI based on Selective Search. Specifically, the WSI is over-segmented into regions which are hierarchically merged until the WSI becomes a single region. Nucleus-oriented similarity measures for region mergence and Nucleus-Cytoplasm color space for histopathological image are specially defined to generate accurate region proposals. Additionally, we propose a new semi-supervised hashing method for image retrieval. The semantic features of images are extracted with Latent Dirichlet Allocation and transformed into binary hashing codes with Supervised Hashing. The methods are tested on a large-scale multi-class database of breast histopathological WSIs. The results demonstrate that for one WSI, our region proposing method can generate 7.3 thousand contoured regions which fit well with 95.8% of the ROIs annotated by pathologists. The proposed hashing method can retrieve a query image among 136 thousand images in 0.29 s and reach precision of 91% with only 10% of images labeled. The unsupervised region proposing method can generate regions as predictions of lesions in histopathological WSI. The region proposals can also serve as the training samples to train machine-learning models for image retrieval. The proposed hashing method can achieve fast and precise image retrieval with small amount of labels. Furthermore, the proposed methods can be potentially applied in online computer-aided-diagnosis systems. Copyright

Proposed actions are no actions: re-modeling an ontology design pattern with a realist top-level ontology.

Science.gov (United States)

Seddig-Raufie, Djamila; Jansen, Ludger; Schober, Daniel; Boeker, Martin; Grewe, Niels; Schulz, Stefan

2012-09-21

Ontology Design Patterns (ODPs) are representational artifacts devised to offer solutions for recurring ontology design problems. They promise to enhance the ontology building process in terms of flexibility, re-usability and expansion, and to make the result of ontology engineering more predictable. In this paper, we analyze ODP repositories and investigate their relation with upper-level ontologies. In particular, we compare the BioTop upper ontology to the Action ODP from the NeOn an ODP repository. In view of the differences in the respective approaches, we investigate whether the Action ODP can be embedded into BioTop. We demonstrate that this requires re-interpreting the meaning of classes of the NeOn Action ODP in the light of the precepts of realist ontologies. As a result, the re-design required clarifying the ontological commitment of the ODP classes by assigning them to top-level categories. Thus, ambiguous definitions are avoided. Classes of real entities are clearly distinguished from classes of information artifacts. The proposed approach avoids the commitment to the existence of unclear future entities which underlies the NeOn Action ODP. Our re-design is parsimonious in the sense that existing BioTop content proved to be largely sufficient to define the different types of actions and plans. The proposed model demonstrates that an expressive upper-level ontology provides enough resources and expressivity to represent even complex ODPs, here shown with the different flavors of Action as proposed in the NeOn ODP. The advantage of ODP inclusion into a top-level ontology is the given predetermined dependency of each class, an existing backbone structure and well-defined relations. Our comparison shows that the use of some ODPs is more likely to cause problems for ontology developers, rather than to guide them. Besides the structural properties, the explanation of classification results were particularly hard to grasp for 'self-sufficient' ODPs as

A PROPOSAL FOR A SUSTAINABLE MODEL BASED UPON UNDERWATER TOURISM RESEARCH IN AYVALIK

Directory of Open Access Journals (Sweden)

A. GÖKDENİZ

2013-03-01

Full Text Available Underwater sports are the activities being done with the aims of witnessing the beauties, hunting, taking photos, the ecology and the archaeology of underwater analysing or finding out the human being’s boundaries by improving the physical and psychological skills of men. The initial aim of this project is to increase the underwater flora and the fauna heritage of Ayvalık and to bring them in tourism. Ayvalık is on the west coast of Turkey. It is getting more and more famous with its underwater richness. Also, to form a new underwater sports centre in order to contribute to the improvement of the region. By providing visual attractiveness, the tourists related to underwater sports will pay attention to Ayvalık and underwater tourism will contribute much to the economy of the region. The aim of this project is to improve the underwater sports which is now a hobby than a sport. In Ayvalık Underwater World study, we dealt with 247 divers and 4 underwater sports club. In this study, we analysed the expectation, satisfaction, demographic and economic level of 247 divers about the services in the region. Interview technique has been used in the study on the 4 underwater sports clubs which are hosting divers. As a conclusion, a report has been prepared in which detailed information and proposals are presented by developing a sustainable marketing model concerned with the underwater sports for those who want to possess information, shareholders of the sector and make analyse about tourism.

An improved interfacial bonding model for material interface modeling

Science.gov (United States)

Lin, Liqiang; Wang, Xiaodu; Zeng, Xiaowei

2016-01-01

An improved interfacial bonding model was proposed from potential function point of view to investigate interfacial interactions in polycrystalline materials. It characterizes both attractive and repulsive interfacial interactions and can be applied to model different material interfaces. The path dependence of work-of-separation study indicates that the transformation of separation work is smooth in normal and tangential direction and the proposed model guarantees the consistency of the cohesive constitutive model. The improved interfacial bonding model was verified through a simple compression test in a standard hexagonal structure. The error between analytical solutions and numerical results from the proposed model is reasonable in linear elastic region. Ultimately, we investigated the mechanical behavior of extrafibrillar matrix in bone and the simulation results agreed well with experimental observations of bone fracture. PMID:28584343

Convective effects in a regulatory and proposed fire model

International Nuclear Information System (INIS)

Wix, S.D.; Hohnstreiter, G.F.

1995-01-01

Radiation is the dominant mode of heat transfer in large fires. However, convection can be as much as 10 to 20 percent of the total heat transfer to an object in a large fire. The current radioactive material transportation packaging regulations include convection as a mode of heat transfer in the accident condition scenario. The current International Atomic Energy Agency Safety Series 6 packaging regulation states ''the convection coefficient shall be that value which the designer can justify if the package were exposed to the specified fire''. The current Title 10, Code of Federal Regulations, Part 71 (10CFR71) packaging regulation states ''when significant, convection heat input must be included on the basis of still, ambient air at 800 degrees C (1475 degrees F)''. Two questions that can arise in an analysts mind from an examination of the packaging regulations is whether convection is significant and whether convection should be included in the design analysis of a radioactive materials transportation container. The objective of this study is to examine the convective effects on an actual radioactive materials transportation package using a regulatory and a proposed thermal boundary condition

Semiotic-conceptual analysis: a proposal

Science.gov (United States)

Priss, Uta

2017-07-01

This paper provides the basic definitions of Semiotic-conceptual analysis (SCA), which is a mathematical modelling of signs as elements of a triadic relation. FCA concept lattices are constructed for each of the three sign components. It is demonstrated how core linguistic and semiotic notions (such as synonymy and icon) can be represented with SCA. While the usefulness of SCA has already been demonstrated in a number of applications and several propositions are proven in this paper, there are still many open questions as to what to do next with SCA. Therefore, this paper is meant as a proposal and encouragement for further development.

Zaštita računarskih mreža Ministarstva odbrane i Vojske Srbije primenom virtuelnog honeyneta / Security of computer network of the Ministry of Defence and the Serbian Armed Forces using virtual honeynets

Directory of Open Access Journals (Sweden)

Zoran Bobar

2009-07-01

Full Text Available U ovom radu obrađena je zaštita računarskih mreža u Ministarstvu odbrane i Vojsci Srbije primenom virtuelnog honeyneta. Zaštita je obrađena sa aspekta arhitekture računarskih mreža koje imaju pristup internetu. Predloženi koncept primene virtuelnog honeyneta uzima u obzir dostignuća nauke u ovoj oblasti u svetu, ostale primenjene metode i tehnike zaštite, mogućnosti i potrebe korisnika i elemente delova računarskog sistema Ministarstva odbrane i Vojske koji bi mogli biti meta napada sa udaljenih mesta globalne (internet mreže. / This paper covers the proposed solution for security of computer network in the Ministry of Defence and the Serbian Armed Forces using virtual honeynets. The security is covered from the aspect of the architecture of computer networks with Internet access. The proposed usage of virtual honeynets for protection takes into account the accomplishments of science in this field as well as security methods and techniques, users' needs and opportunities along with the computer network components of the MoD and the SAF that can be targets for attack.

Latent classification models

DEFF Research Database (Denmark)

Langseth, Helge; Nielsen, Thomas Dyhre

2005-01-01

parametric family ofdistributions.  In this paper we propose a new set of models forclassification in continuous domains, termed latent classificationmodels. The latent classification model can roughly be seen ascombining the \\NB model with a mixture of factor analyzers,thereby relaxing the assumptions...... classification model, and wedemonstrate empirically that the accuracy of the proposed model issignificantly higher than the accuracy of other probabilisticclassifiers....

Development of a 3-dimensional calculation model of the Danish research reactor DR3 to analyse a proposal to a new core design called ring-core

Energy Technology Data Exchange (ETDEWEB)

Nonboel, E

1985-07-01

A 3-dimensional calculation model of the Danish research reactor DR3 has been developed. Demands of a more effective utilization of the reactor and its facilities has required a more detailed calculation tool than applied so far. A great deal of attention has been devoted to the treatment of the coarse control arms. The model has been tested against measurements with satisfying results. Furthermore the model has been used to analyse a proposal to a new core design called ring-core where 4 central fuel elements are replaced by 4 dummy elements to increase the thermal flux in the center of the reactor. (author)

Making sense of resilience: a review from the field of paediatric psycho-oncology and a proposal of a model for its study

Directory of Open Access Journals (Sweden)

Carmina Castellano-Tejedor

2014-10-01

Full Text Available This article is intended to review the concept of resilience from the scope of paediatric psycho-oncology. The origin, its different definitions and its suitability of application in the field of serious physical illness - such as cancer - will be analyzed. Furthermore, the differences between resilience and other concepts commonly associated or confused with it, such as post-traumatic growth or benefit finding, will be discussed. Finally, a proposal for a comprehensive model of resilience in paediatric cancer will be put forward.

Study on a model for future occupational health: proposal for an occupational health service model in Japan.

Science.gov (United States)

Higashi, Toshiaki

2006-10-01

The Study Model for Future Occupational Health (funded by a research grant from the Ministry of Health, Welfare and Labor) is a joint research project involving various organizations and agencies undertaken from 2002 to 2004. Society has undergone a dramatic transformation due to technological developments and internationalization. At the same time a low birth rate and an aging population have resulted in an increase in both the percentage of workers experiencing strong anxiety and stress in relation to their jobs and the working environment and the number of suicides. As a natural consequence, occupational health services are now expected to provide EAP, consulting and other functions that were formerly considered outside the realm of occupational health. In consideration of this background, the present study propose the following issues to provide a model for future occupational health services that meet the conditions presently confronted by each worker. 1. How to provide occupational health services and occupational physicians' services: 1) a basic time of 20 minutes of occupational health services per year should be allotted to each worker and to all workers; 2) the obligatory regulations should be revised to expand the obligation from businesses each with 50 or more employees under the present laws to businesses each with 30 or more employees. 2. Providers of occupational health services and occupational physicians' services: (1) reinforcement of outside occupational health agencies; (2) fostering occupational health consultant firms; (3) development of an institute of occupational safety and health; (4) support of activities by authorized occupational physicians in the field; (5) expanding of joint selection of occupational physicians including subsidy increase and the extension of a period of subsidy to five hears; (6) licensing of new entry into occupational health undertaking. 3. Introduction of new report system: (1) establishment of the obligation to

Proposing a Model for Patient Admission and NFC Mobile Payment by Biometric Identification and Smart Health Card

Directory of Open Access Journals (Sweden)

Mahdi Barkhordari Firouzabadi

2016-02-01

Full Text Available Abstract Following the advances in mobile communication and information technology, smart phones have been used in a wide variety of commercial, social, entertainment, file sharing and health transactions and applications. The current procedures in healthcare environment for patient registration, appointment scheduling and payment are time consuming and somehow tiresome. Traditionally, patients were supposed to fill out registration forms, wait for being called, and finally stand in long lines for payment procedures. In some places, appointment could be done online via web but still the patient has to walk in with appointment card and in our case, provide the insurance booklet to the front desk personnel to pay for services and receive discounts for insurance. Therefore, the present study intended to propose a model using Near Field Communication-enabled mobile application for a medical clinic which currently offers online and call services for making an appointment, though patient waiting time is still too much in the current process of payment for services.

Organizational change in quality management aspects: a quantitative proposal for classification

Directory of Open Access Journals (Sweden)

André Tavares de Aquino

Full Text Available Abstract Periodically, organizations need to change the quality management aspects of processes and products in order to suit the demands of their internal and external (consumer and competitor market environments. In the context of the present study, quality management changes involve tools, programs, methods, standards and procedures that can be applied. The purpose of this study is to help senior management to identify types of change and, consequently, determine how it should be correctly conducted within an organization. The methodology involves a classification model, with multicriteria support, and three organizational change ratings were adopted (the extremes, type I and type II, as confirmed in the literature, and the intermediary, proposed herein. The multicriteria method used was ELECTRE TRI and the model was applied to two companies of the Textile Local Productive Arrangement in Pernambuco, Brazil. The results are interesting and show the consistency and coherence of the proposed classification model.

A Comparative Analysis of Three Proposed Federal Renewable Electricity Standards

Energy Technology Data Exchange (ETDEWEB)

Sullivan, Patrick [National Renewable Energy Lab. (NREL), Golden, CO (United States); Logan, Jeffrey [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States); Short, Walter [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2009-05-01

This paper analyzes potential impacts of proposed national renewable electricity standard (RES) legislation. An RES is a mandate requiring certain electricity retailers to provide a minimum share of their electricity sales from qualifying renewable power generation. The analysis focuses on draft bills introduced individually by Senator Jeff Bingaman and Representative Edward Markey, and jointly by Representative Henry Waxman and Markey. The analysis uses NREL's Regional Energy Deployment System (ReEDS) model to evaluate the impacts of the proposed RES requirements on the U.S. energy sector in four scenarios.

Call for proposals for the Joint Canada-Israel Health Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

23 nov. 2017 ... Call for proposals for the Joint Canada-Israel Health Research Program 2018 competition ... developmental neurobiology; neuro-immunology; neuroendocrinology; regenerative medicine in brain disease; cellular and molecular basis of cognition; modeling brain function; imaging of neural processes ...

Three-dimensional modeling of unsaturated flow in the vicinity of proposed exploratory shaft facilities at Yucca Mountain, Nevada

International Nuclear Information System (INIS)

Rockhold, M.L.; Sagar, B.; Connelly, M.P.

1992-04-01

This report describes the results of a study to investigate the influence of proposed exploratory shafts on the moisture distribution within unsaturated, fractured rock at Yucca Mountain, Nevada. The long-term effects of exploratory shafts at Yucca Mountain are important in the estimation of potential waste migration and fate, while short-term effects may be important in the planning and interpretation of tests performed at the site. The PORFLO-3 computer code was used for simulation of moisture flow through the geologic units adjacent to the ESF. Rather than represent fractures as discrete elements, an equivalent continuum was stipulated, in which the fractured units were assigned equivalent or composite hydrologic properties. Explicit treatment of fractures is not feasible because of the extremely large number of fractures contained in the site-scale problem and the difficulties in characterizing and modeling the fracture geometries

Proposing a Formalised Model for Mindful Information Systems Offshoring

Science.gov (United States)

Costello, Gabriel J.; Coughlan, Chris; Donnellan, Brian; Gadatsch, Andreas

The central thesis of this chapter is that mathematical economics can provide a novel approach to the examination of offshoring business decisions and provide an impetus for future research in the area. A growing body of research indicates that projected cost savings from IT offshoring projects are not being met. Furthermore, evidence suggests that decision-making processes have been more emotional than rational, and that many offshoring arrangements have been rushed into without adequate analysis of the true costs involved. Building on the concept of mindfulness and mindlessness introduced to the IS literature by Swanson and Ramiller, a cost equation is developed using “deductive reasoning rather than inductive study” in the tradition of mathematical economics. The model endeavours to capture a wide range of both the quantitative and qualitative parameters. Although the economic model is illustrated against the background of a European scenario, the theoretical framework is generic and applicable to organisations in any global location.

Quasilinear Extreme Learning Machine Model Based Internal Model Control for Nonlinear Process

Directory of Open Access Journals (Sweden)

Dazi Li

2015-01-01

Full Text Available A new strategy for internal model control (IMC is proposed using a regression algorithm of quasilinear model with extreme learning machine (QL-ELM. Aimed at the chemical process with nonlinearity, the learning process of the internal model and inverse model is derived. The proposed QL-ELM is constructed as a linear ARX model with a complicated nonlinear coefficient. It shows some good approximation ability and fast convergence. The complicated coefficients are separated into two parts. The linear part is determined by recursive least square (RLS, while the nonlinear part is identified through extreme learning machine. The parameters of linear part and the output weights of ELM are estimated iteratively. The proposed internal model control is applied to CSTR process. The effectiveness and accuracy of the proposed method are extensively verified through numerical results.

Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.

Directory of Open Access Journals (Sweden)

Xiaoli Guo

Full Text Available BACKGROUND: Olig1 is a basic helix-loop-helix (bHLH transcription factor that is essential for oligodendrogenesis and efficient remyelination. However, its role in neurodegenerative disorders has not been well-elucidated. METHODOLOGY/PRINCIPAL FINDINGS: Here we investigated the effects of Olig1 deficiency on experimental autoimmune encephalomyelitis (EAE, an animal model of multiple sclerosis (MS. We show that the mean disease onset of myelin oligodendrocyte glycoprotein (MOG-induced EAE in Olig1(-/- mice is significantly slower than wide-type (WT mice (19.8 ± 2.2 in Olig1(-/- mice and 9.5 ± 0.3 days in WT mice. In addition, 10% of Olig1(-/- mice did not develop EAE by the end of the observation periods (60 days. The severity of EAE, the extent of demyelination, and the activation of microglial cells and astrocytes in spinal cords, were significantly milder in Olig1(-/- mice compared with WT mice in the early stage. Moreover, the visual function, as assessed by the second-kernel of multifocal electroretinograms, was better preserved, and the number of degenerating axons in the optic nerve was significantly reduced in Olig1(-/- mice. Interestingly, Olig1 deficiency had no effect on T cell response capability, however, it reduced the expression of myelin proteins such as MOG, myelin basic protein (MBP and myelin-associated glycoprotein (MAG. The expression of Olig2 remained unchanged in the optic nerve and brain, and it was reduced in the spinal cord of Olig1(-/- mice. CONCLUSIONS/SIGNIFICANCE: Our results suggest that the Olig1 signaling pathways may be involved in the incidence rate and the severity of neurological symptoms in MS.

76 FR 70829 - Proposed Information Collection (Architect-Engineer Fee Proposal) Activity; Comment Request

Science.gov (United States)

2011-11-15

... DEPARTMENT OF VETERANS AFFAIRS [OMB Control No. 2900-0208] Proposed Information Collection (Architect--Engineer Fee Proposal) Activity; Comment Request AGENCY: Veterans Health Administration.... Architect--Engineer Fee Proposal, VA Form 10-6298. b. Daily Log (Contract Progress Report--Formal Contract...

Proposal of a Framework for Innovation Competencies Development and Assessment (FINCODA

Directory of Open Access Journals (Sweden)

Juan A. Marin-Garcia

2016-12-01

Full Text Available In this article we propose a model of innovation competence of people, based on the existing literature to integrate and complement the existing models. The main contribution of this work consists in demonstrating the differences and similarities of current models and in providing a conceptual definition for each model element. In this way, both researchers and people in charge of Human Resources in companies can obtain a framework to design measuring instruments to assess the innovation competence, which can fulfil the twofold demand requirement of validity and reliability.

Queering Constructs: Proposing a Dynamic Gender and Sexuality Model

Science.gov (United States)

Jourian, T. J.

2015-01-01

Higher education educators commonly understand social identities, including gender, to be fluid and dynamic. Lev's (2004) model of four components of sexual identity is commonly used to demonstrate the fluidity of sex, gender, and sexuality for individuals, but it does little to address the fixedness of those constructs. Through a multipronged…

Mapping care processes within a hospital: from theory to a web-based proposal merging enterprise modelling and ISO normative principles.

Science.gov (United States)

Staccini, Pascal; Joubert, Michel; Quaranta, Jean-François; Fieschi, Marius

2005-03-01

Today, the economic and regulatory environment, involving activity-based and prospective payment systems, healthcare quality and risk analysis, traceability of the acts performed and evaluation of care practices, accounts for the current interest in clinical and hospital information systems. The structured gathering of information relative to users' needs and system requirements is fundamental when installing such systems. This stage takes time and is generally misconstrued by caregivers and is of limited efficacy to analysts. We used a modelling technique designed for manufacturing processes (IDEF0/SADT). We enhanced the basic model of an activity with descriptors extracted from the Ishikawa cause-and-effect diagram (methods, men, materials, machines, and environment). We proposed an object data model of a process and its components, and programmed a web-based tool in an object-oriented environment. This tool makes it possible to extract the data dictionary of a given process from the description of its elements and to locate documents (procedures, recommendations, instructions) according to each activity or role. Aimed at structuring needs and storing information provided by directly involved teams regarding the workings of an institution (or at least part of it), the process-mapping approach has an important contribution to make in the analysis of clinical information systems.

Proposal for a Graded Authorisation Model for the Use of Ionising Radiation in Ireland

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-10-15

The Radiological Protection Institute of Ireland RPII intends to refocus, streamline and modernise its regulation of the use of ionising radiation in Ireland. This report provides detailed proposals for establishing a graded approach to authorisation in which regulators will be able to focus on higher risk practices by simplifying requirements placed on those of lower risk, without compromising the safety or security of the Irish population. These proposals build on RPII strategic analyses that seek to navigate a course between the competing pressures of public sector reform and the rapid technological changes in medical and nuclear arenas, which challenge the licensing and advisory functions of RPII. A graded approach to authorisation provides the potential for a sustainable basis for future regulation in Ireland. Such an approach would be in line with the forthcoming EURATOM Basic Safety Standards and with general current regulatory trends, which are moving away from one-size-fits-all approaches towards more adaptive, interactive and transparent regulation. In seeking this reform, the RPII also aims to fully utilize the benefits of the internet and electronic communications and to improve the transparency of its processes. These proposals have been developed using a robust, comprehensive project methodology involving a root and branch analysis of current and potential future approaches to authorisation. A series of facilitated workshops were held, punctuated by intensive periods of focused co-enquiry, involving all members of the RPII Regulatory Service. This approach made the fullest use of the decades of expertise and knowledge of these staff. It also provided the platform for developing a common vision of a graded approach to authorisation; for agreeing the criteria for differentiating between levels of authorisation; for collecting the necessary evidence for decision-making and for identifying the implications of these decisions. The graded approach presented

Proposal for a Graded Authorisation Model for the Use of Ionising Radiation in Ireland

International Nuclear Information System (INIS)

2012-10-01

The Radiological Protection Institute of Ireland RPII intends to refocus, streamline and modernise its regulation of the use of ionising radiation in Ireland. This report provides detailed proposals for establishing a graded approach to authorisation in which regulators will be able to focus on higher risk practices by simplifying requirements placed on those of lower risk, without compromising the safety or security of the Irish population. These proposals build on RPII strategic analyses that seek to navigate a course between the competing pressures of public sector reform and the rapid technological changes in medical and nuclear arenas, which challenge the licensing and advisory functions of RPII. A graded approach to authorisation provides the potential for a sustainable basis for future regulation in Ireland. Such an approach would be in line with the forthcoming EURATOM Basic Safety Standards and with general current regulatory trends, which are moving away from one-size-fits-all approaches towards more adaptive, interactive and transparent regulation. In seeking this reform, the RPII also aims to fully utilize the benefits of the internet and electronic communications and to improve the transparency of its processes. These proposals have been developed using a robust, comprehensive project methodology involving a root and branch analysis of current and potential future approaches to authorisation. A series of facilitated workshops were held, punctuated by intensive periods of focused co-enquiry, involving all members of the RPII Regulatory Service. This approach made the fullest use of the decades of expertise and knowledge of these staff. It also provided the platform for developing a common vision of a graded approach to authorisation; for agreeing the criteria for differentiating between levels of authorisation; for collecting the necessary evidence for decision-making and for identifying the implications of these decisions. The graded approach presented

Methodology proposal for the development of Tillage Models - (Part II) Indexes of physical-mechanic characterization of the soil and development of a tillage model

International Nuclear Information System (INIS)

Lozano Osorno Fernando; Castillo Herran, Bernardo

1999-01-01

A proposal was presented for the elaboration of tillage models that allows making decisions on systems of soil preparation (including the option of zero tillage) starting with measurements of the condition of these. After following a plan of sampling of diverse physical-mechanics parameters of the soil and of a statistical process of correlation, they were chosen as representative variables: the apparent density, the cone index, the content of humidity and the cohesion (torsion box, proves in situ); not only such parameters are very related to each other, but rather they also make possible to estimate other variables of interest like the total porosity appropriately, the macro-porosity, the hydraulic conductivity and in general the soil resistance, which makes viable to choose methods of removal of the soil in function of the initial state of the same one. In the proven case it could verify the possibility to establish systems of tillage reduction

Toward a new model of scientific publishing: Discussion and a proposal

Directory of Open Access Journals (Sweden)

Dwight eKravitz

2011-12-01

Full Text Available The current system of publishing in the neurosciences, is notable for its redundancy, inconsistency, sluggishness, and opacity. These problems persist, and grow worse, because of a continuing failure to fully leverage new technology. Online access has eliminated space limits within peer-reviewed journals, yet we continue to deny publication. Each submission of a rejected manuscript requires the entire machinery of peer review to creak to life. This redundancy causes delays, inconsistency, and increases the burden on authors, reviewers, and editors. Further, reviewers serve a key role in the process but their performance is not tracked; yet alone rewarded. This misalignment of incentives contributes to the inconsistency and sluggishness that pervades peer review. The current system also interferes with the primary purpose of modern journals, providing a quick way of prioritizing the literature. Reviews are written to gauge publication rather than scientific merit and there is no guarantee that the journal’s criteria agree with those of an individual researcher, making any prioritization opaque and noisy at best.The focus of this special issue is the future form of post-publication reception, and the development of a marketplace where a paper rises and falls based on its reception from the field. However, the information that accompanies a paper into the marketplace is as important as the marketplace’s mechanics. Beyond suggestions as to the mechanisms of reception, we propose an update to the system of publishing in which publication is guaranteed, but pre-publication peer review still occurs, giving the authors the opportunity to revise their work following a mini pre-reception from the field. This step also provides a consistent set of rankings and reviews to the marketplace, allowing for early prioritization and stabilizing its early dynamics. We further propose to improve the general quality of reviewing by providing tangible rewards to

On nonlocally interacting metrics, and a simple proposal for cosmic acceleration

Science.gov (United States)

Vardanyan, Valeri; Akrami, Yashar; Amendola, Luca; Silvestri, Alessandra

2018-03-01

We propose a simple, nonlocal modification to general relativity (GR) on large scales, which provides a model of late-time cosmic acceleration in the absence of the cosmological constant and with the same number of free parameters as in standard cosmology. The model is motivated by adding to the gravity sector an extra spin-2 field interacting nonlocally with the physical metric coupled to matter. The form of the nonlocal interaction is inspired by the simplest form of the Deser-Woodard (DW) model, α R1/squareR, with one of the Ricci scalars being replaced by a constant m2, and gravity is therefore modified in the infrared by adding a simple term of the form m21/squareR to the Einstein-Hilbert term. We study cosmic expansion histories, and demonstrate that the new model can provide background expansions consistent with observations if m is of the order of the Hubble expansion rate today, in contrast to the simple DW model with no viable cosmology. The model is best fit by w0~‑1.075 and wa~0.045. We also compare the cosmology of the model to that of Maggiore and Mancarella (MM), m2R1/square2R, and demonstrate that the viable cosmic histories follow the standard-model evolution more closely compared to the MM model. We further demonstrate that the proposed model possesses the same number of physical degrees of freedom as in GR. Finally, we discuss the appearance of ghosts in the local formulation of the model, and argue that they are unphysical and harmless to the theory, keeping the physical degrees of freedom healthy.

Can theory be embedded in visual interventions to promote self-management? A proposed model and worked example.

Science.gov (United States)

Williams, B; Anderson, A S; Barton, K; McGhee, J

2012-12-01

Nurses are increasingly involved in a range of strategies to encourage patient behaviours that improve self-management. If nurses are to be involved in, or indeed lead, the development of such interventions then processes that enhance the likelihood that they will lead to evidence that is both robust and usable in practice are required. Although behavioural interventions have been predominantly based on written text or the spoken word increasing numbers are now drawing on visual media to communicate their message, despite only a growing evidence base to support it. The use of such media in health interventions is likely to increase due to technological advances enabling easier and cheaper production, and an increasing social preference for visual forms of communication. However, the development of such media is often highly pragmatic and developed intuitively rather than with theory and evidence informing their content and form. Such a process may be at best inefficient and at worst potentially harmful. This paper performs two functions. Firstly, it discusses and argues why visual based interventions may be a powerful media for behaviour change; and secondly, it proposes a model, developed from the MRC Framework for the Development and Evaluation of Complex Interventions, to guide the creation of theory informed visual interventions. It employs a case study of the development of an intervention to motivate involvement in a lifestyle intervention among people with increased cardiovascular risk. In doing this we argue for a step-wise model which includes: (1) the identification of a theoretical basis and associated concepts; (2) the development of visual narrative to establish structure; (3) the visual rendering of narrative and concepts; and (4) the assessment of interpretation and impact among the intended patient group. We go on to discuss the theoretical and methodological limitations of the model. Copyright © 2012 Elsevier Ltd. All rights reserved.

PROPOSAL FOR A NEW LOD AND MULTI-REPRESENTATION CONCEPT FOR CITYGML

Directory of Open Access Journals (Sweden)

M.-O. Löwner

2016-10-01

Full Text Available The Open Geospatial Consortium (OGC CityGML standard offers a Level of Detail (LoD concept that enables the representation of CityGML features from a very detailed to a less detailed description. Due to a rising application variety, the current LoD concept seems to be too inflexible. Here, we present a multi representation concept (MRC that enables a user-defined definition of LoDs. Because CityGML is an international standard, official profiles of the MRC are proposed. However, encoding of the defined profiles reveals many problems including mapping the conceptual model to the normative encoding, missing technologies and so on. Therefore, we propose to use the MRC as a meta model for the further definition of an LoD concept for CityGML 3.0.

An efficient interpolation technique for jump proposals in reversible-jump Markov chain Monte Carlo calculations

Science.gov (United States)

Farr, W. M.; Mandel, I.; Stevens, D.

2015-01-01

Selection among alternative theoretical models given an observed dataset is an important challenge in many areas of physics and astronomy. Reversible-jump Markov chain Monte Carlo (RJMCMC) is an extremely powerful technique for performing Bayesian model selection, but it suffers from a fundamental difficulty and it requires jumps between model parameter spaces, but cannot efficiently explore both parameter spaces at once. Thus, a naive jump between parameter spaces is unlikely to be accepted in the Markov chain Monte Carlo (MCMC) algorithm and convergence is correspondingly slow. Here, we demonstrate an interpolation technique that uses samples from single-model MCMCs to propose intermodel jumps from an approximation to the single-model posterior of the target parameter space. The interpolation technique, based on a kD-tree data structure, is adaptive and efficient in modest dimensionality. We show that our technique leads to improved convergence over naive jumps in an RJMCMC, and compare it to other proposals in the literature to improve the convergence of RJMCMCs. We also demonstrate the use of the same interpolation technique as a way to construct efficient ‘global’ proposal distributions for single-model MCMCs without prior knowledge of the structure of the posterior distribution, and discuss improvements that permit the method to be used in higher dimensional spaces efficiently. PMID:26543580

A proposed conceptual model of green practices impacting on the tourism business and their performances – A case of Phu Quoc island Vietnam

Directory of Open Access Journals (Sweden)

Vu Minh Hieu

2017-06-01

Full Text Available The purpose of this article is to propose a conceptual green practices model in the tourism industry of Phu Quoc island (destination in Vietnam. The model is developed with purpose of providing direction for researchers to empirically examine relationships among demographic variables, innovation characteristics, performance expectancy, social influence, facilitating conditions and effort expectancy, funding availability and environment and business performances. This study uses the secondary research data which is collected from different sources as books, journals, research papers and other online and print media (publications on the subject. The main method used in this study is the content review and analysis. The author suggests that an empirical study should be done to confirm if relationships of variables exit or need to be changed to adapt with the currents of the destination to increase business performance. This model is expected to contribute to the theory of tourism and to apply to Phu Quoc island.

Mixture of Regression Models with Single-Index

OpenAIRE

Xiang, Sijia; Yao, Weixin

2016-01-01

In this article, we propose a class of semiparametric mixture regression models with single-index. We argue that many recently proposed semiparametric/nonparametric mixture regression models can be considered special cases of the proposed model. However, unlike existing semiparametric mixture regression models, the new pro- posed model can easily incorporate multivariate predictors into the nonparametric components. Backfitting estimates and the corresponding algorithms have been proposed for...

Mathematical Modelling in Engineering: A Proposal to Introduce Linear Algebra Concepts

Science.gov (United States)

Cárcamo Bahamonde, Andrea; Gómez Urgelles, Joan; Fortuny Aymemí, Josep

2016-01-01

The modern dynamic world requires that basic science courses for engineering, including linear algebra, emphasise the development of mathematical abilities primarily associated with modelling and interpreting, which are not exclusively calculus abilities. Considering this, an instructional design was created based on mathematical modelling and…

Real-time object-oriented programming: studies and proposals

International Nuclear Information System (INIS)

Fouquier, Gilles

1996-01-01

This thesis contributes to the introduction of real-time features in object-oriented programming. Object-oriented programming favours modularity and reusability. Therefore, its application to real-time introduces many theoretical and conceptual problems. To deal with these problems, a new real-time object-oriented programming model is presented. This model is based on the active object model which allows concurrence and maintains the encapsulation property. The real-time aspect is treated by replacing the concept of task by the concept of method processing and by associating a real-time constraint to each message (priority or deadline). The set of all the running methods is scheduled. This model, called ATOME, contains several sub-models to deal with the usual concurrence control integrating their priority and deadline processing. The classical HPF and EDF scheduling avoid priority or deadline inversion. This model and its variants are new proposals to program real-time applications in the object-oriented way, therefore easing reusability and code writing. The feasibility of this approach is demonstrated by extending and existing active object-based language to real-time, in using the rules defined in the ATOME model. (author) [fr

Minocycline promotes the generation of dendritic cells with regulatory properties.

Science.gov (United States)

Kim, Narae; Park, Chan-Su; Im, Sun-A; Kim, Ji-Wan; Lee, Jae-Hee; Park, Young-Jun; Song, Sukgil; Lee, Chong-Kil

2016-08-16

Minocycline, which has long been used as a broad-spectrum antibiotic, also exhibits non-antibiotic properties such as inhibition of inflammation and angiogenesis. In this study, we show that minocycline significantly enhances the generation of dendritic cells (DCs) from mouse bone marrow (BM) cells when used together with GM-CSF and IL-4. DCs generated from BM cells in the presence of minocycline (Mino-DCs) demonstrate the characteristics of regulatory DCs. Compared with control DCs, Mino-DCs are resistant to subsequent maturation stimuli, impaired in MHC class II-restricted exogenous Ag presentation, and show decreased cytokine secretion. Mino-DCs also show decreased ability to prime allogeneic-specific T cells, while increasing the expansion of CD4+CD25+Foxp3+ T regulatory cells both in vitro and in vivo. In addition, pretreatment with MOG35-55 peptide-pulsed Mino-DCs ameliorates clinical signs of experimental autoimmune encephalitis induced by MOG peptide injection. Our study identifies minocycline as a new pharmacological agent that could be potentially used to increase the production of regulatory DCs for cell therapy to treat autoimmune disorders, allergy, and transplant rejection.

UNINETTUNO – międzynarodowy uniwersytet na odległość

Directory of Open Access Journals (Sweden)

Maria Lamberti

2009-01-01

Full Text Available Artykuł omawia działalność UNINETTUNO, największego wirtualnego uniwersytetu włoskiego o zasięgu międzynarodowym. Università Telematica Uninettuno to realizowany od 1990 roku, początkowo jako konsorcjum NETTUNO, włoski projekt kształcenia na odległość na poziomie uniwersyteckim. Obecnie działa w jedenastu krajach basenu Morza Śródziemnomorskiego, w Wielkiej Brytanii, Albanii i na Ukrainie. Jego działalność opiera się na oryginalnym psychopedagogicznym modelu opracowanym przez prof. M.A. Garito z Rzymu. Dzięki bardzo rozbudowanej bazie technologicznej studenci mogą uczestniczyć w wykładach organizowanych w czasie rzeczywistym jako wideokonferencje, słuchać wykładów transmitowanych za pośrednictwem sieci telewizji satelitarnych oraz korzystać z wykładów umieszczonych w Internecie w dogodnym dla siebie czasie. Bogata i wielojęzyczna oferta programowa stanowi ogromną szansę dla osób pracujących, które mogą zdalnie zdobyć dyplom uniwersytecki w wielu cenionych na rynku pracy specjalnościach.