WorldWideScience

Sample records for model literature overview

  1. Carbon trading: Literature overview

    NARCIS (Netherlands)

    Kerste, M.; Weda, J.; Rosenboom, N.

    2010-01-01

    From Pigou and Coase to the Kyoto Protocol, carbon trading has resulted in pricing of the negative externalities emanating from pollution. At the request of Duisenberg school of finance, this report highlights leading literature and empirical findings on ‘carbon trading’, amongst others addressing

  2. Modelling Overview

    DEFF Research Database (Denmark)

    Larsen, Lars Bjørn; Vesterager, Johan

    This report provides an overview of the existing models of global manufacturing, describes the required modelling views and associated methods and identifies tools, which can provide support for this modelling activity.The model adopted for global manufacturing is that of an extended enterprise s...

  3. Carbon Trading. Literature Overview

    International Nuclear Information System (INIS)

    Kerste, M.; Weda, J.; Rosenboom, N.

    2010-12-01

    From Pigou and Coase to the Kyoto Protocol, carbon trading has resulted in pricing of the negative externalities emanating from pollution. This report highlights leading literature and empirical findings on carbon trading, amongst others addressing the relevant carbon and related markets, the (lack of) success of carbon trading so far and room for improvement as well as its impact on investments in emission reduction. This report is part of a set of SEO-reports on finance and sustainability. The other reports deal with: Financing the Transition to Sustainable Energy; Innovations in financing environmental and social sustainability; and Sustainable investment.

  4. Literature overview for greenhouse effect part VI

    International Nuclear Information System (INIS)

    Orthofer, R.; Nevyjel, A.

    1997-10-01

    On behalf of the Austrian Federal Ministry of Environment, Youth and Family Affairs the current scientific and technical literature in the subject area of greenhouse effect and global climatic change is investigated by performing quarterly on-line retrieval searches in the databases Compendex, Enviroline, NTIS and ULIT. This report contains the research results of the period of September to December 1996. From the observed 199 citations the most significant 50 citations were selected, evaluated and summarised in a literature review. Relevant topics are (1) research on causes, effects and modelling, (2) possible agricultural, technical, economic and political control measures, (3) strategies and actions taken in various countries, and (4) international co-ordination. The review is based on the abstracts from the databases and for the most interesting publications - from the original literature. Five similar reports have been published previously which cover the literature since January 1994. (author)

  5. [Depersonalization syndrome after acquired brain damage. Overview based on 3 case reports and the literature and discussion of etiological models].

    Science.gov (United States)

    Paulig, M; Böttger, S; Sommer, M; Prosiegel, M

    1998-12-01

    Depersonalization after brain damage is still only rarely reported and poorly understood. We describe three patients between the ages of 21 and 25 who experienced depersonalization and derealization for periods of 6 weeks to 4 months, two after traumatic brain injury, the third after surgical and radiation treatment of a pineocytoma. Each one believed to be living in a nightmare and thought about committing suicide in order to wake up. One patient developed symptoms as described in Cotard delusion. Aspects of neuroanatomy, psychodynamics, and anthropology are discussed with reference to the literature. Frontal and temporal lesions seem only to play a facilitating role but not to be a necessary condition. There is evidence for additional influence of psychological and premorbid personality factors. Summarizing the current state of information we consider depersonalization with the experience of being in a dream or being dead as a heuristic reaction to brain damage. Similar models have already been discussed in neuropsychological disorders as for instance reduplicative paramnesias, neglect, and anosognosia.

  6. Overview. Rethinking the grey literature's definition

    International Nuclear Information System (INIS)

    Ikeda, Kiyoshi

    2012-01-01

    Grey literature said to do difficult to obtain through commercial publishers. Recently, according to the spread of institutional repositories, grey literature is published on the Web and its full text is open to the public, then it has become easily accessible. Yet, the accessibility of grey literature has not been fully resolved. In this paper, the author introduces the definition of grey literature based on the discussion of the International Conference on Grey Literature (International Conference on Grey literature) and tries to reorganize and discuss on issues concerning the problems of grey literature accessibility. The author indicates that there are still many challenges in this field, also indicates that stable access to the sources on the Web is not always guaranteed. It is concluded that expertises and experiences of a librarian should be leveraged to get solutions regarding the accessibility of grey literature. (author)

  7. Overview of literature on nuclear energy

    International Nuclear Information System (INIS)

    Koch, P.; Schmid, M.; Marti, M.

    2009-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) attempts to deliver an objective review of various topics connected with nuclear energy. These include the risks posed by the use of nuclear energy, its relevance to the environment, social acceptance, ethical aspects and effects on health. Ten controversial topics are discussed concerning the use of nuclear energy and its acceptance or non-acceptance. The study concentrates on safety, accident and risk analysis, environmental relevance with respect to climate protection and nuclear wastes. Comparisons are made with other forms of energy generation. The methods used to compile the overview are discussed

  8. Integrated Medical Model Overview

    Science.gov (United States)

    Myers, J.; Boley, L.; Foy, M.; Goodenow, D.; Griffin, D.; Keenan, A.; Kerstman, E.; Melton, S.; McGuire, K.; Saile, L.; hide

    2015-01-01

    The Integrated Medical Model (IMM) Project represents one aspect of NASA's Human Research Program (HRP) to quantitatively assess medical risks to astronauts for existing operational missions as well as missions associated with future exploration and commercial space flight ventures. The IMM takes a probabilistic approach to assessing the likelihood and specific outcomes of one hundred medical conditions within the envelope of accepted space flight standards of care over a selectable range of mission capabilities. A specially developed Integrated Medical Evidence Database (iMED) maintains evidence-based, organizational knowledge across a variety of data sources. Since becoming operational in 2011, version 3.0 of the IMM, the supporting iMED, and the expertise of the IMM project team have contributed to a wide range of decision and informational processes for the space medical and human research community. This presentation provides an overview of the IMM conceptual architecture and range of application through examples of actual space flight community questions posed to the IMM project.

  9. Digital colposcopy: ready for use? An overview of literature.

    Science.gov (United States)

    Louwers, J A; Kocken, M; ter Harmsel, W A; Verheijen, R H M

    2009-01-01

    The aims of this review were to summarise the various methods of digital colposcopy and to provide an overview of their efficacy. We conducted a literature search and focused on papers that described a technique for colposcopy, other than conventional colposcopy, and compared this with conventional colposcopy and/or histology and included digitalisation of the process. All papers have been classified in one of the following categories: digital imaging and telecolposcopy, spectroscopy, computerised colposcopy, optical coherence tomography and confocal microcolposcopy. Among the most promising developments is spectroscopy, allowing a more or less automated analysis and interpretation of the colposcopic image.

  10. SUBSTANCE ABUSE, DEPENDENCE AND THE WORKPLACE: A LITERATURE OVERVIEW

    Directory of Open Access Journals (Sweden)

    Smook, Breggie

    2014-04-01

    Full Text Available Substance abuse and dependence among the employed have massive cost implications for South Africa. Employers are legally obliged to provide opportunities for the treatment of substance dependence before dismissal is considered. Problem areas are the following: inadequate identification of employees with substance-abuse problems, infrequent treatment referrals, and overlooking of substance abuse in the workplace. This article attempts to address these issues by providing an overview of literature dealing with the problem of substance abuse and dependence in the workplace. Addressing this problem calls for specialist intervention measures, which are discussed in the article.

  11. An Overview of BRDF Models

    OpenAIRE

    Montes Soldado, Rosana; Ure??a Almagro, Carlos

    2012-01-01

    This paper is focused on the Bidirectional Reflectance Distribution Function (BRDF) in the context of algorithms for computational production of realistic synthetic images. We provide a review of most relevant analytical BRDF models proposed in the literature which have been used for realistic rendering. We also show different approaches used for obtaining efficient models from acquired reflectance data, and the related function fitting techniques, suitable for using that data in efficient re...

  12. The MVP Model: Overview and Application

    Science.gov (United States)

    Keller, John M.

    2017-01-01

    This chapter contains an overview of the MVP model that is used as a basis for the other chapters in this issue. It also contains a description of key steps in the ARCS-V design process that is derived from the MVP model and a summary of a design-based research study illustrating the application of the ARCS-V model.

  13. Innovations in financing environmental and social sustainability: Literature overview

    NARCIS (Netherlands)

    Kerste, M.; Weda, J.; Rosenboom, N.

    2010-01-01

    Innovative finance instruments can help increase funding of investments aimed at environmental and social sustainability. At the request of Duisenberg school of finance, this report highlights leading literature and empirical findings on ‘innovations in financing environmental and social

  14. Overview of literature on nuclear energy; Literaturuebersicht Kernenergie

    Energy Technology Data Exchange (ETDEWEB)

    Koch, P.; Schmid, M. [B.S.S. Volkswirtschaftliche Beratung AG, Basel (Switzerland); Marti, M. [Risicare GmbH, Zuerich (Switzerland)

    2009-07-15

    This final report for the Swiss Federal Office of Energy (SFOE) attempts to deliver an objective review of various topics connected with nuclear energy. These include the risks posed by the use of nuclear energy, its relevance to the environment, social acceptance, ethical aspects and effects on health. Ten controversial topics are discussed concerning the use of nuclear energy and its acceptance or non-acceptance. The study concentrates on safety, accident and risk analysis, environmental relevance with respect to climate protection and nuclear wastes. Comparisons are made with other forms of energy generation. The methods used to compile the overview are discussed

  15. LSD Flashbacks: An Overview of the Literature for Counselors.

    Science.gov (United States)

    Silling, S. Marc

    1980-01-01

    Surveyed the literature to delineate the etiology of LSD flashbacks. Concluded that adverse experiences while using LSD are predictive of flashbacks; physiological effects of LSD use may linger after the drug has been metabolized; and individuals who have flashbacks are highly suggestive and play a flashback "role."

  16. Phase 1a: Literature overview of health in South Africa

    CSIR Research Space (South Africa)

    Botha, Adele

    2016-12-01

    Full Text Available This chapter provides a detailed explanation of each of the phases that were applied during the development of the DHIE. To conceptualise the DHIE for South Africa, it was important to understand the literature on the existing local health situation...

  17. The Five-Factor Model: General Overview

    Directory of Open Access Journals (Sweden)

    A A Vorobyeva

    2011-12-01

    Full Text Available The article describes the five-factor model (FFM, giving an overview of its history, basic dimensions, cross-cultural research conducted on the model and highlights some practical studies based on the FFM, including the studies on job performance, leader performance and daily social interactions. An overview of the recent five-factor theory is also provided. According to the theory, the five factors are encoded in human genes, therefore it is almost impossible to change the basic factors themselves, but a person's behavior might be changed due to characteristic adaptations which do not alter personality dimensions, only a person's behavior.

  18. Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature

    Science.gov (United States)

    Fijan, Sabina

    2014-01-01

    Probiotics are defined as live microorganisms, which when administered in adequate amounts, confer a health benefit on the host. Health benefits have mainly been demonstrated for specific probiotic strains of the following genera: Lactobacillus, Bifidobacterium, Saccharomyces, Enterococcus, Streptococcus, Pediococcus, Leuconostoc, Bacillus, Escherichia coli. The human microbiota is getting a lot of attention today and research has already demonstrated that alteration of this microbiota may have far-reaching consequences. One of the possible routes for correcting dysbiosis is by consuming probiotics. The credibility of specific health claims of probiotics and their safety must be established through science-based clinical studies. This overview summarizes the most commonly used probiotic microorganisms and their demonstrated health claims. As probiotic properties have been shown to be strain specific, accurate identification of particular strains is also very important. On the other hand, it is also demonstrated that the use of various probiotics for immunocompromised patients or patients with a leaky gut has also yielded infections, sepsis, fungemia, bacteraemia. Although the vast majority of probiotics that are used today are generally regarded as safe and beneficial for healthy individuals, caution in selecting and monitoring of probiotics for patients is needed and complete consideration of risk-benefit ratio before prescribing is recommended. PMID:24859749

  19. Irradiation creep models - an overview

    International Nuclear Information System (INIS)

    Matthews, J.R.; Finnis, M.W.

    1988-01-01

    The modelling of irradiation creep is now highly developed but many of the basic processes underlying the models are poorly understood. A brief introduction is given to the theory of cascade interactions, point defect clustering and dislocation climb. The range of simple irradiation creep models is reviewed including: preferred nucleation of interstitial loops; preferred absorption of point defects by dislocations favourably orientated to an applied stress; various climb-enhanced glide and recovery mechanisms, and creep driven by internal stresses produced by irradiation growth. A range of special topics is discussed including: cascade effects; creep transients; structural and induced anisotropy; and the effect of impurities. The interplay between swelling and growth with thermal and irradiation creep is emphasized. A discussion is given on how irradiation creep theory should best be developed to assist the interpretation of irradiation creep observations and the requirements of reactor designers. (orig.)

  20. Building Information Modeling Comprehensive Overview

    Directory of Open Access Journals (Sweden)

    Sergey Kalinichuk

    2015-07-01

    Full Text Available The article is addressed to provide a comprehensive review on recently accelerated development of the Information Technology within project market such as industrial, engineering, procurement and construction. Author’s aim is to cover the last decades of the growth of the Information and Communication Technology in construction industry in particular Building Information Modeling and testifies that the problem of a choice of the effective project realization method not only has not lost its urgency, but has also transformed into one of the major condition of the intensive technology development. All of it has created a great impulse on shortening the project duration and has led to the development of various schedule compression techniques what becomes a focus of modern construction.

  1. Solar models: An historical overview

    International Nuclear Information System (INIS)

    Bahcall, John N.

    2003-01-01

    I will summarize in four slides the 40 years of development of the standard solar model that is used to predict solar neutrino fluxes and then describe the current uncertainties in the predictions. I will dispel the misconception that the p-p neutrino flux is determined by the solar luminosity and present a related formula that gives, in terms of the p-p and 7 Be neutrino fluxes, the ratio of the rates of the two primary ways of terminating the p-p fusion chain. I will also attempt to explain why it took so long, about three and a half decades, to reach a consensus view that new physics is being learned from solar neutrino experiments. Finally, I close with a personal confession

  2. Detection of soy proteins in processed foods: Literature overview and new experimental work

    NARCIS (Netherlands)

    Koppelman, S.J.; Lakemond, C.M.M.; Vlooswijk, R.A.A.; Hefle, S.L.

    2004-01-01

    Several tests for the detection of soy proteins in foods have been described in the literature, and some are commercially available. This article gives an overview of these methods and discusses the advantages and disadvantages of each individual method. Based on the conclusions of this inventory,

  3. An Overview of the Literature: Research in P-12 Engineering Education

    Science.gov (United States)

    Mendoza Díaz, Noemi V.; Cox, Monica F.

    2012-01-01

    This paper presents an extensive overview of preschool to 12th grade (P-12) engineering education literature published between 2001 and 2011. Searches were conducted through education and engineering library engines and databases as well as queries in established publications in engineering education. More than 50 publications were found,…

  4. Radicalization: An Overview and Annotated Bibliography of Open-Source Literature

    Science.gov (United States)

    2006-12-15

    particularly with liberal, democratic, and humanistic Muslims Phares points to Jihadism as the main root cause of terrorism and suggests that defending...An Overview and Annotated Bibliography of Open-Source Literature 155 of ambiguity), epistemic and existential needs theory (need for closure...This book presents Terror Management Theory, which addresses behavioral and psychological responses to terrorist events. An existential

  5. An overview of the literature on sexual harassment: Perpetrator, theory, and treatment issues

    OpenAIRE

    Pina, Afroditi; Gannon, Theresa A.; Saunders, Benjamin

    2009-01-01

    Sexual harassment has been recognized as a serious problem in the literature over the past 30 years. In this\\ud paper, we review the existing research surrounding the phenomenon of sexual harassment, paying particular\\ud attention to factors of relevance for understanding perpetrators of sexual harassment. We also provide an\\ud overview of the perplexing nature of sexual harassment and the various concerns that have surrounded the\\ud topic leading to its recognition. The different theoretical...

  6. Overview of recent developments in attenuation models

    International Nuclear Information System (INIS)

    Riera, J.D.

    2001-01-01

    Attenuation equations predict features of the seismic motion, such as the horizontal and vertical peak ground accelerations (PGA), the peak ground velocities (PGV) and the 5% damped spectral acceleration response (SA), in terms of the earthquake magnitude and distance from source to site. Occasionally other factors, like the type of faulting, are considered in the attenuation expressions. An overview of recent developments in this field is presented in the paper, including a discussion of the applicability of various models for short source to site distances. In such a case, i.e. in the neighbourhood of the epicentral region, which is of utmost importance in Nuclear Power Plant applications, the use of two parameters to define the earthquake size is suggested, instead of the single parameter, a magnitude scale. Recent evidence of the importance in such situations of so-called directivity effects, which require a more complete description of the focal mechanism, completes the paper. (author)

  7. Describing the concept of infinite among art, literature, philosophy and science: a pedagogical-didactic overview

    Directory of Open Access Journals (Sweden)

    Paolo Di Sia

    2014-09-01

    Full Text Available In this work an interesting overview concerning the human attempts in the description of the concept of infinite is presented. This peculiar concept represents a cardinal point in the history of human culture, because man, with different modalities, has always compared with it. Historically the main followed streams were two: the rational and the irrational approaches. In the first approach we find disciplines such as philosophy, mathematics and physics; the second is the domain of literature, arts and religion. Some activities for developing ideas about the intuitive concept of the infinity at the level of compulsory education will be also given.

  8. Use of Essential Oils to Inhibit Alicyclobacillus acidoterrestris: a short overview of the literature

    Directory of Open Access Journals (Sweden)

    Antonio eBevilacqua

    2011-09-01

    Full Text Available Essential oils (EOs are promising and friendly antimicrobials for the prolongation of the shelf life of many foods. They have been extensively used to inhibit spoiling and pathogenic microorganisms of many kinds of productslike fruit juices and acidic drinks. Therefore, they could be used successfully to control the germination of spores of Alicyclobacillus acidoterrestris, that finds in these products an optimal environment for growth.This paper reports a brief overview of the literature available, focusing on the effects of EOs towards alicyclobacilli.

  9. Teacher educators' competences in fostering student teachers' proficiency in teaching and learning with technology : An overview of relevant research literature

    NARCIS (Netherlands)

    Dana Uerz; Monique Volman; Marijke Kral

    2018-01-01

    Teacher educators play an important role in preparing student teachers to integrate technology into their classrooms. This article presents an overview of research literature on teacher educators' competences in preparing their students to teach with technology. A literature search yielded 26

  10. Degradation of the mechanical properties in ASR-affected concrete : Overview and modeling

    NARCIS (Netherlands)

    Esposito, R.; Hendriks, M.A.N.

    2012-01-01

    The Alkali-Silica Reaction (ASR) can generate harmful effects in the concrete structures. In this paper the degradation of the mechanical properties of ASR-affected concrete is studied by comparing the experimental results available in literature. An overview of the macroscopic material modelling

  11. An overview of biomedical literature search on the World Wide Web in the third millennium.

    Science.gov (United States)

    Kumar, Prince; Goel, Roshni; Jain, Chandni; Kumar, Ashish; Parashar, Abhishek; Gond, Ajay Ratan

    2012-06-01

    Complete access to the existing pool of biomedical literature and the ability to "hit" upon the exact information of the relevant specialty are becoming essential elements of academic and clinical expertise. With the rapid expansion of the literature database, it is almost impossible to keep up to date with every innovation. Using the Internet, however, most people can freely access this literature at any time, from almost anywhere. This paper highlights the use of the Internet in obtaining valuable biomedical research information, which is mostly available from journals, databases, textbooks and e-journals in the form of web pages, text materials, images, and so on. The authors present an overview of web-based resources for biomedical researchers, providing information about Internet search engines (e.g., Google), web-based bibliographic databases (e.g., PubMed, IndMed) and how to use them, and other online biomedical resources that can assist clinicians in reaching well-informed clinical decisions.

  12. Omalizumab for Chronic Urticaria: A Case Series and Overview of the Literature

    Directory of Open Access Journals (Sweden)

    Ilya Ivyanskiy

    2012-01-01

    Full Text Available Omalizumab is a recombinant humanized monoclonal antibody that blocks the high-affinity Fc receptor of IgE. Omalizumab has been approved for the treatment of moderate to severe asthma; however, there is currently more and more data showing promising results in the management also of chronic urticaria. We present a case series of 19 patients with chronic urticaria treated in a university department with omalizumab and give an overview of the existing literature comprising an additional 59 cases as well as a total of 139 patients enrolled in two randomized controlled trials comparing omalizumab with placebo. The collective evidence points to omalizumab as a safe and effective treatment option for patients with chronic urticaria who do not sufficiently respond to standard therapy as recommended by existing guidelines.

  13. Application of Operational Research Techniques in Operating Room Scheduling Problems: Literature Overview

    Directory of Open Access Journals (Sweden)

    Şeyda Gür

    2018-01-01

    Full Text Available Increased healthcare costs are pushing hospitals to reduce costs and increase the quality of care. Operating rooms are the most important source of income and expense for hospitals. Therefore, the hospital management focuses on the effectiveness of schedules and plans. This study includes analyses of recent research on operating room scheduling and planning. Most studies in the literature, from 2000 to the present day, were evaluated according to patient characteristics, performance measures, solution techniques used in the research, the uncertainty of the problem, applicability of the research, and the planning strategy to be dealt within the solution. One hundred seventy studies were examined in detail, after scanning the Emerald, Science Direct, JSTOR, Springer, Taylor and Francis, and Google Scholar databases. To facilitate the identification of these studies, they are grouped according to the different criteria of concern and then, a detailed overview is presented.

  14. Technology Acceptance Model: A Survey of Literature

    Directory of Open Access Journals (Sweden)

    Priyanka Surendran

    2013-07-01

    Full Text Available The technology acceptance model has been a theory that is most widely used to explain an individual’s acceptance of an information system. This study has reviewed numerous literatures available in this area. The different studies in this area were evaluated to understand the modifications that were done on this model. The paper then tries to provide an insight on future trends in the technology acceptance model.

  15. Sexuality in older adults (65+) — an overview of the recent literature, part 2: body image and sexual satisfaction

    OpenAIRE

    Træen, Bente; Carvalheira, Ana; Lundin Kvalem, Ingela; Štulhofer, Aleksandar; Janssen, Erick; Graham, Cynthia A.; Hald, Gert Martin; Enzlin, Paul

    2016-01-01

    Objectives: the aim of the paper is to provide an overview of the literature published 2005-2015 on sexual satisfaction and body image in older adults. Method: A narrative literature search using the PsycINFO database was conducted. Results: Although women in general seem less satisfied with their bodies than men, particularly in sexual contexts, older women appear to be less vulnerable to body-related dissatisfaction than younger women. Despite the age-specific dynamics of sexual satisfactio...

  16. Sport prostheses and prosthetic adaptations for the upper and lower limb amputees : an overview of peer reviewed literature

    NARCIS (Netherlands)

    Bragaru, Mihai; Dekker, Rienk; Geertzen, Jan H. B.

    Background: Sport prostheses are used by both upper- and lower-limb amputees while participating in sports and other physical activities. Although the number of these devices has increased over the past decade, no overview of the peer reviewed literature describing them has been published

  17. PECS and VOCAs to enable students with developmental disabilities to make requests: An overview of the literature

    NARCIS (Netherlands)

    Lancioni, G.E.; O'Reilly, M.F.; Cuvo, A.J.; Singh, N.N.; Sigafoos, J.; Didden, H.C.M.

    2007-01-01

    This paper provides an overview of the literature dealing with the use of the Picture Exchange Communication System (PECS) and voice output communication aids (VOCAs) for promoting the performance of requests by students with developmental disabilities. Computerized and manual searches were carried

  18. PECS and VOCAs to Enable Students with Developmental Disabilities to Make Requests: An Overview of the Literature

    Science.gov (United States)

    Lancioni, Giulio E.; O'Reilly, Mark F.; Cuvo, Anthony J.; Singh, Nirbhay N.; Sigafoos, Jeff; Didden, Robert

    2007-01-01

    This paper provides an overview of the literature dealing with the use of the Picture Exchange Communication System (PECS) and voice output communication aids (VOCAs) for promoting the performance of requests by students with developmental disabilities. Computerized and manual searches were carried out to identify the studies published during the…

  19. An introduction to spiritual psychology: overview of the literature, east and west.

    Science.gov (United States)

    Miovic, Michael

    2004-01-01

    This article outlines the philosophical background to spiritual psychology and selectively reviews Western and Eastern literature on the subject. The world views of theism, atheism, and agnosticism are defined and critiqued, and the boundaries of scientific knowledge discussed. The views of James, Jung, and Freud are reviewed, and the contributions of humanistic psychology noted. Contemporary spiritual psychology is then summarized with reference to recent literature on theistic psychotherapy, Buddhist psychology, mind-body medicine, and transpersonal psychology. Sri Aurobindo's work is introduced as a modern Asian perspective on theistic psychology, and his model of the relationship between the "soul" and the unconscious described. Finally, a brief clinical vignette is given.

  20. Adolescent Cellphone Use While Driving: An Overview of the Literature and Promising Future Directions for Prevention

    Directory of Open Access Journals (Sweden)

    M. Kit Delgado

    2016-06-01

    Full Text Available Motor vehicle crashes are the leading cause of death in adolescents, and drivers aged 16–19 are the most likely to die in distracted driving crashes. This paper provides an overview of the literature on adolescent cellphone use while driving, focusing on the crash risk, incidence, risk factors for engagement, and the effectiveness of current mitigation strategies. We conclude by discussing promising future approaches to prevent crashes related to cellphone use in adolescents. Handheld manipulation of the phone while driving has been shown to have a 3 to 4-fold increased risk of a near crash or crash, and eye glance duration greater than 2 seconds increases crash risk exponentially. Nearly half of U.S. high school students admit to texting while driving in the last month, but the frequency of use according to vehicle speed and high-risk situations remains unknown. Several risk factors are associated with cell phone use while driving including: parental cellphone use while driving, social norms for quick responses to text messages, and higher levels of temporal discounting. Given the limited effectiveness of current mitigation strategies such as educational campaigns and legal bans, a multi-pronged behavioral and technological approach addressing the above risk factors will be necessary to reduce this dangerous behavior in adolescents.

  1. Influence diagram of physiological and environmental factors affecting heart rate variability: an extended literature overview

    Directory of Open Access Journals (Sweden)

    Julien Fatisson

    2016-09-01

    Full Text Available Heart rate variability (HRV corresponds to the adaptation of the heart to any stimulus. In fact, among the pathologies affecting HRV the most, there are the cardiovascular diseases and depressive disorders, which are associated with high medical cost in Western societies. Consequently, HRV is now widely used as an index of health.In order to better understand how this adaptation takes place, it is necessary to examine which factors directly influence HRV, whether they have a physiological or environmental origin. The primary objective of this research is therefore to conduct a literature review in order to get a comprehensive overview of the subject.The system of these factors affecting HRV can be divided into the following five categories: physiological and pathological factors, environmental factors, lifestyle factors, non-modifiable factors and effects. The direct interrelationships between these factors and HRV can be regrouped into an influence diagram. This diagram can therefore serve as a basis to improve daily clinical practice as well as help design even more precise research protocols.

  2. A critical overview of the current myofascial pain literature - March 2016.

    Science.gov (United States)

    Dommerholt, Jan; Hooks, Todd; Finnegan, Michelle; Grieve, Rob

    2016-04-01

    The worldwide interest in myofascial pain syndrome (MPS) and trigger points (TrPs) is reflected in the increasing number of publications. In this overview of the literature, we included 26 studies, case reports and review articles by authors from 18 different countries. Several research groups are exploring the characteristic of TrPs such as Chen and colleagues, who continued their work on the quantification of the taut bands. Meng and colleagues studied the relationships between TrPs and central sensitization, while Yu and colleagues examined the electrophysiological characteristics that occur as a result of active TrPs. Several researchers used objective measurements to determine clinical outcomes, such as Koppenhaver and colleagues who measured objective changes in the function and nociceptive sensitivity of lumbar multifidus muscle subjects with low back pain. Turo and colleagues quantified muscle tissue changes after dry needling in chronic myofascial pain using elastography. Multiple studies explored various treatment options for TrPs, such as dry needling, injections with lidocaine or granisetron, traditional Thai massage, self-myofascial release, kinesiotaping, and monochromatic infrared photo energy, among others. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Adolescent Cellphone Use While Driving: An Overview of the Literature and Promising Future Directions for Prevention

    Science.gov (United States)

    Delgado, M. Kit; Wanner, Kathryn J.; McDonald, Catherine

    2016-01-01

    Motor vehicle crashes are the leading cause of death in adolescents, and drivers aged 16–19 are the most likely to die in distracted driving crashes. This paper provides an overview of the literature on adolescent cellphone use while driving, focusing on the crash risk, incidence, risk factors for engagement, and the effectiveness of current mitigation strategies. We conclude by discussing promising future approaches to prevent crashes related to cellphone use in adolescents. Handheld manipulation of the phone while driving has been shown to have a 3 to 4-fold increased risk of a near crash or crash, and eye glance duration greater than 2 seconds increases crash risk exponentially. Nearly half of U.S. high school students admit to texting while driving in the last month, but the frequency of use according to vehicle speed and high-risk situations remains unknown. Several risk factors are associated with cell phone use while driving including: parental cellphone use while driving, social norms for quick responses to text messages, and higher levels of temporal discounting. Given the limited effectiveness of current mitigation strategies such as educational campaigns and legal bans, a multi-pronged behavioral and technological approach addressing the above risk factors will be necessary to reduce this dangerous behavior in adolescents. PMID:27695663

  4. Effective implementation of research into practice: an overview of systematic reviews of the health literature

    Directory of Open Access Journals (Sweden)

    Fraser Alec

    2011-06-01

    Full Text Available Abstract Background The gap between research findings and clinical practice is well documented and a range of interventions has been developed to increase the implementation of research into clinical practice. Findings A review of systematic reviews of the effectiveness of interventions designed to increase the use of research in clinical practice. A search for relevant systematic reviews was conducted of Medline and the Cochrane Database of Reviews 1998-2009. 13 systematic reviews containing 313 primary studies were included. Four strategy types are identified: audit and feedback; computerised decision support; opinion leaders; and multifaceted interventions. Nine of the reviews reported on multifaceted interventions. This review highlights the small effects of single interventions such as audit and feedback, computerised decision support and opinion leaders. Systematic reviews of multifaceted interventions claim an improvement in effectiveness over single interventions, with effect sizes ranging from small to moderate. This review found that a number of published systematic reviews fail to state whether the recommended practice change is based on the best available research evidence. Conclusions This overview of systematic reviews updates the body of knowledge relating to the effectiveness of key mechanisms for improving clinical practice and service development. Multifaceted interventions are more likely to improve practice than single interventions such as audit and feedback. This review identified a small literature focusing explicitly on getting research evidence into clinical practice. It emphasizes the importance of ensuring that primary studies and systematic reviews are precise about the extent to which the reported interventions focus on changing practice based on research evidence (as opposed to other information codified in guidelines and education materials.

  5. Effective implementation of research into practice: an overview of systematic reviews of the health literature.

    Science.gov (United States)

    Boaz, Annette; Baeza, Juan; Fraser, Alec

    2011-06-22

    The gap between research findings and clinical practice is well documented and a range of interventions has been developed to increase the implementation of research into clinical practice. A review of systematic reviews of the effectiveness of interventions designed to increase the use of research in clinical practice. A search for relevant systematic reviews was conducted of Medline and the Cochrane Database of Reviews 1998-2009. 13 systematic reviews containing 313 primary studies were included. Four strategy types are identified: audit and feedback; computerised decision support; opinion leaders; and multifaceted interventions. Nine of the reviews reported on multifaceted interventions. This review highlights the small effects of single interventions such as audit and feedback, computerised decision support and opinion leaders. Systematic reviews of multifaceted interventions claim an improvement in effectiveness over single interventions, with effect sizes ranging from small to moderate. This review found that a number of published systematic reviews fail to state whether the recommended practice change is based on the best available research evidence. This overview of systematic reviews updates the body of knowledge relating to the effectiveness of key mechanisms for improving clinical practice and service development. Multifaceted interventions are more likely to improve practice than single interventions such as audit and feedback. This review identified a small literature focusing explicitly on getting research evidence into clinical practice. It emphasizes the importance of ensuring that primary studies and systematic reviews are precise about the extent to which the reported interventions focus on changing practice based on research evidence (as opposed to other information codified in guidelines and education materials).

  6. Probiotic guidelines and physician practice: a cross-sectional survey and overview of the literature.

    Science.gov (United States)

    Draper, K; Ley, C; Parsonnet, J

    2017-08-24

    Probiotic use by patients and physicians has dramatically increased over the last decade, although definitive evidence is often lacking for their use. We examined probiotic-prescribing practices among health care providers (HCP) at a tertiary medical centre and compared these practices to clinical guidelines. HCP at the Stanford Medical Center received a survey on probiotic prescribing practices including choice of probiotic and primary indications. A broad overview of the literature was performed. Among 2,331 HCP surveyed, 632 responded. Of the 582 of these who routinely prescribed medications, 61% had recommended probiotic foods or supplements to their patients. Women and gastroenterologists were more likely to prescribe probiotics (odds ratio (OR): 1.5, 95% confidence interval (CI): 1.0-2.1; OR: 3.9, 95% CI: 1.5-10.1, respectively). Among probiotic prescribers, 50% prescribed inconsistently or upon patient request, and 40% left probiotic choice to the patient. Common indications for probiotics, particularly Lactobacillus GG, were prevention and treatment of antibiotic-associated diarrhoea (79 and 66%, respectively). Probiotics were often prescribed for 'general bowel health' or at patient request (27 and 39% of responders, respectively). Most respondents (63%) thought an electronic medical record (EMR) pop-up would change probiotic prescribing patterns. However, a review of published guidelines and large trials found inconsistencies in probiotic indications, dosages and strain selection. Probiotic prescribing is common but lacks consistency, with choice of probiotic frequently left to the patient, even for indications with some strain-specific evidence. Implementation of EMR pop-ups/pocket guides may increase consistency in probiotic prescribing, although the lack of clear and consistent guidelines must first be addressed with large, well-designed clinical trials.

  7. Hallucinations in Healthy Older Adults: An Overview of the Literature and Perspectives for Future Research

    Directory of Open Access Journals (Sweden)

    Johanna C. Badcock

    2017-07-01

    Full Text Available KEY POINTS➢ Studies suggest a substantial minority of healthy older adults have hallucinatory experiences, in line with existing evidence on hallucinations in other age groups, though it is still unclear if hallucination prevalence increases or declines with age in older cohorts.➢ Stigma attached to both hallucinations and ageing leads to considerable under-reporting of these experiences in healthy older adults and may negatively bias how professionals, family members, and the public respond.➢ Why and when hallucinations in healthy older adults remit, persist, or progress to other clinical disorders remains poorly understood.➢ Current evidence points to a range of factors associated with hallucinations in older adults including decline in sensory or cognitive functioning, poor sleep, and psychosocial stressors (e.g., social isolation, loneliness, and bereavement, highlighting the need for accurate assessment and tailored interventions.Hallucinations, though common in youth and younger adults, are not the preserve of these age groups. Accumulating evidence shows that hallucinatory experiences are also present at surprisingly high rates in healthy older adults in the general community. Furthermore, stigma and misunderstanding of hallucinations, together with ageism, may lead to under-reporting of these experiences by older adults, and misdiagnosis or mismanagement by health and mental health practitioners. Consequently, improved public and professional knowledge is needed about the nature and significance of hallucinations with advancing age. The purpose of this review is to provide a comprehensive overview, and critical analysis, of research on the prevalence, psychosocial, and neurobiological factors associated with hallucinations in people aged 60 years and over. To the best of our knowledge, this is the first review of its kind in the literature. The evidence supports a dynamic conceptualization of hallucinations, in which the

  8. eHealth as the Next-Generation Perinatal Care: An Overview of the Literature.

    Science.gov (United States)

    van den Heuvel, Josephus Fm; Groenhof, T Katrien; Veerbeek, Jan Hw; van Solinge, Wouter W; Lely, A Titia; Franx, Arie; Bekker, Mireille N

    2018-06-05

    Unrestricted by time and place, electronic health (eHealth) provides solutions for patient empowerment and value-based health care. Women in the reproductive age are particularly frequent users of internet, social media, and smartphone apps. Therefore, the pregnant patient seems to be a prime candidate for eHealth-supported health care with telemedicine for fetal and maternal conditions. This study aims to review the current literature on eHealth developments in pregnancy to assess this new generation of perinatal care. We conducted a systematic literature search of studies on eHealth technology in perinatal care in PubMed and EMBASE in June 2017. Studies reporting the use of eHealth during prenatal, perinatal, and postnatal care were included. Given the heterogeneity in study methods, used technologies, and outcome measurements, results were analyzed and presented in a narrative overview of the literature. The literature search provided 71 studies of interest. These studies were categorized in 6 domains: information and eHealth use, lifestyle (gestational weight gain, exercise, and smoking cessation), gestational diabetes, mental health, low- and middle-income countries, and telemonitoring and teleconsulting. Most studies in gestational diabetes and mental health show that eHealth applications are good alternatives to standard practice. Examples are interactive blood glucose management with remote care using smartphones, telephone screening for postnatal depression, and Web-based cognitive behavioral therapy. Apps and exercise programs show a direction toward less gestational weight gain, increase in step count, and increase in smoking abstinence. Multiple studies describe novel systems to enable home fetal monitoring with cardiotocography and uterine activity. However, only few studies assess outcomes in terms of fetal monitoring safety and efficacy in high-risk pregnancy. Patients and clinicians report good overall satisfaction with new strategies that enable

  9. Overview of the model component in ECOCLIM

    DEFF Research Database (Denmark)

    Geels, Camilla; Boegh, Eva; Bendtsen, J

    and atmospheric models. We will use the model system to 1) quantify the potential effects of climate change on ecosystem exchange of GHG and 2) estimate the impacts of changes in management practices including land use change and nitrogen (N) loads. Here the various model components will be introduced...

  10. [Non-EC workers in Italy: an overview of the literature and an attempt to test various hypotheses].

    Science.gov (United States)

    Strozza, S

    1995-09-01

    "The essay presents an overview of the interpretations offered in scientific literature about causes and effects of non-EC [European Community] immigrants' integration into the Italian labor market....The essay uses the aggregate data of [the] Labor Ministry integrated by local surveys to answer some questions...[concerning] the link between sex, Italian region, place of origin and sector of activity...and the complementarity or competition with [the] Italian labor force." (SUMMARY IN ENG AND FRE) excerpt

  11. Overview of cellular automaton models for corrosion

    International Nuclear Information System (INIS)

    Perez-Brokate, Cristian Felipe; De Lamare, Jacques; Dung di Caprio; Feron, Damien; Chausse, Annie

    2014-01-01

    A review of corrosion process modeling using cellular automata methods is presented. This relatively new and growing approach takes into account the stochastic nature of the phenomena and uses physico-chemical rules to make predictions at a mesoscopic scale. Milestone models are analyzed and perspectives are established. (authors)

  12. Sport prostheses and prosthetic adaptations for the upper and lower limb amputees: an overview of peer reviewed literature.

    Science.gov (United States)

    Bragaru, Mihai; Dekker, Rienk; Geertzen, Jan H B

    2012-09-01

    Sport prostheses are used by both upper- and lower-limb amputees while participating in sports and other physical activities. Although the number of these devices has increased over the past decade, no overview of the peer reviewed literature describing them has been published previously. Such an overview will allow specialists to choose appropriate prostheses based on available scientific evidence rather than on personal experience or preference. To provide an overview of the sport prostheses as they are described by the papers published in peer reviewed literature. Literature review. Four electronic databases were searched using free text and Medical Subject Headings (MESH) terms. Papers were included if they concerned a prosthesis or a prosthetic adaptation used in sports. Papers were excluded if they did not originate from peer reviewed sources, if they concerned prostheses for body parts other than the upper or lower limbs, if they concerned amputations distal to the wrist or ankle, or if they were written in a language other than English. Twenty-four papers were included in this study. The vast majority contained descriptive data and consisted of expert opinions and technical notes. Data concerning the energy efficiency, technical characteristics and special mechanical properties of prostheses or prosthetic adaptations for sports, other than running, are scarce.

  13. Population balance modelling of fluidized bed melt granulation: an overview

    NARCIS (Netherlands)

    Tan, H.S.; Goldschmidt, M.J.V.; Boerefijn, R.; Hounslow, M.J.; Salman, A.; Kuipers, J.A.M.

    2005-01-01

    This paper presents an overview of the work undertaken by our group to identify and quantify the rates processes active in fluidized bed melt granulation (FBMG). The process involves the identification and development of physically representative models to mechanistically describe FBMG using both

  14. Frontier models for evaluating environmental efficiency: an overview

    NARCIS (Netherlands)

    Oude Lansink, A.G.J.M.; Wall, A.

    2014-01-01

    Our aim in this paper is to provide a succinct overview of frontier-based models used to evaluate environmental efficiency, with a special emphasis on agricultural activity. We begin by providing a brief, up-to-date review of the main approaches used to measure environmental efficiency, with

  15. Radioactive waste disposal assessment - overview of biosphere processes and models

    International Nuclear Information System (INIS)

    Coughtrey, P.J.

    1992-09-01

    This report provides an overview of biosphere processes and models in the general context of the radiological assessment of radioactive waste disposal as a basis for HMIP's response to biosphere aspects of Nirex's submissions for disposal of radioactive wastes in a purpose-built repository at Sellafield, Cumbria. The overview takes into account published information from the UK as available from Nirex's safety and assessment research programme and HMIP's disposal assessment programme, as well as that available from studies in the UK and elsewhere. (Author)

  16. Overview of Animal Models of Obesity

    Science.gov (United States)

    Lutz, Thomas A.; Woods, Stephen C.

    2012-01-01

    This is a review of animal models of obesity currently used in research. We have focused upon more commonly utilized models since there are far too many newly created models to consider, especially those caused by selective molecular genetic approaches modifying one or more genes in specific populations of cells. Further, we will not discuss the generation and use of inducible transgenic animals (induced knock-out or knock-in) even though they often bear significant advantages compared to traditional transgenic animals; influences of the genetic modification during the development of the animals can be minimized. The number of these animal models is simply too large to be covered in this chapter. PMID:22948848

  17. Overview of the Biomass Scenario Model

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Steve [Lexidyne, LLC, Colorado Springs, CO (United States)

    2015-09-01

    This report describes the structure of the October 2012 version of the Biomass Scenario Model (BSM) in considerable detail, oriented towards readers with a background or interest in the underlying modeling structures. Readers seeking a less-detailed summary of the BSM may refer to Peterson (2013). BSM aims to provide a framework for exploring the potential contribution of biofuel technologies to the transportation energy supply for the United States over the next several decades. The model has evolved significantly from the prototype developed as part of the Role of Biomass in America" tm s Energy Future (RBAEF) project. BSM represents the supply chain surrounding conversion pathways for multiple fuel products, including ethanol, butanol, and infrastructure-compatible biofuels such as diesel, jet fuel, and gasoline.

  18. Business Process Modeling Notation - An Overview

    Directory of Open Access Journals (Sweden)

    Alexandra Fortiş

    2006-01-01

    Full Text Available BPMN represents an industrial standard created to offer a common and user friendly notation to all the participants to a business process. The present paper aims to briefly present the main features of this notation as well as an interpretation of some of the main patterns characterizing a business process modeled by the working fluxes.

  19. Overview of Wave to Wire Models

    DEFF Research Database (Denmark)

    Nielsen, Kim; Kramer, Morten Mejlhede; Ferri, Francesco

    A “Wave to Wire” (W2W) model is a numerical tool that can calculate the power output from a specified Wave Energy Converter (WEC), under specified ocean wave conditions. The tool can be used to assess and optimize the performance of a Wave Energy Converter (WEC) design and provide knowledge...

  20. NASA Standard for Models and Simulations: Philosophy and Requirements Overview

    Science.gov (United States)

    Blattnig, Steve R.; Luckring, James M.; Morrison, Joseph H.; Sylvester, Andre J.; Tripathi, Ram K.; Zang, Thomas A.

    2013-01-01

    Following the Columbia Accident Investigation Board report, the NASA Administrator chartered an executive team (known as the Diaz Team) to identify those CAIB report elements with NASA-wide applicability and to develop corrective measures to address each element. One such measure was the development of a standard for the development, documentation, and operation of models and simulations. This report describes the philosophy and requirements overview of the resulting NASA Standard for Models and Simulations.

  1. Reviewing the research methods literature: principles and strategies illustrated by a systematic overview of sampling in qualitative research.

    Science.gov (United States)

    Gentles, Stephen J; Charles, Cathy; Nicholas, David B; Ploeg, Jenny; McKibbon, K Ann

    2016-10-11

    Overviews of methods are potentially useful means to increase clarity and enhance collective understanding of specific methods topics that may be characterized by ambiguity, inconsistency, or a lack of comprehensiveness. This type of review represents a distinct literature synthesis method, although to date, its methodology remains relatively undeveloped despite several aspects that demand unique review procedures. The purpose of this paper is to initiate discussion about what a rigorous systematic approach to reviews of methods, referred to here as systematic methods overviews, might look like by providing tentative suggestions for approaching specific challenges likely to be encountered. The guidance offered here was derived from experience conducting a systematic methods overview on the topic of sampling in qualitative research. The guidance is organized into several principles that highlight specific objectives for this type of review given the common challenges that must be overcome to achieve them. Optional strategies for achieving each principle are also proposed, along with discussion of how they were successfully implemented in the overview on sampling. We describe seven paired principles and strategies that address the following aspects: delimiting the initial set of publications to consider, searching beyond standard bibliographic databases, searching without the availability of relevant metadata, selecting publications on purposeful conceptual grounds, defining concepts and other information to abstract iteratively, accounting for inconsistent terminology used to describe specific methods topics, and generating rigorous verifiable analytic interpretations. Since a broad aim in systematic methods overviews is to describe and interpret the relevant literature in qualitative terms, we suggest that iterative decision making at various stages of the review process, and a rigorous qualitative approach to analysis are necessary features of this review type

  2. Digital Marketing Maturity Models: Overview and Comparison

    OpenAIRE

    Elina Bakhtieva

    2017-01-01

    The variety of available digital tools, strategies and activities might confuse and disorient even an experienced marketer. This applies in particular to B2B companies, which are usually less flexible in uptaking of digital technology than B2C companies. B2B companies are lacking a framework that corresponds to the specifics of the B2B business, and which helps to evaluate a company’s capabilities and to choose an appropriate path. A B2B digital marketing maturity model helps to fill this gap...

  3. Storage yard operations in container terminals : Literature overview, trends, and research directions

    NARCIS (Netherlands)

    Carlo, Hector J.; Vis, Iris F. A.; Roodbergen, Kees Jan

    2014-01-01

    Inbound and outbound containers are temporarily stored in the storage yard at container terminals. A combination of container demand increase and storage yard capacity scarcity create complex operational challenges for storage yard managers. This paper presents an in-depth overview of storage yard

  4. Seaside operations in container terminals : literature overview, trends, and research directions

    NARCIS (Netherlands)

    Carlo, Héctor J.; Vis, Iris F.A.; Roodbergen, Kees Jan

    Seaside operations are considered the bottleneck operation in most container terminals around the world. This paper presents an in-depth updated overview of the seaside operations at container terminals and highlights current trends and developments. We review and classify scientific journal papers

  5. The Investigation into Motivations, Success Factors and Barriers Among Women Small Business Owners: An Overview of Extant Literature

    Directory of Open Access Journals (Sweden)

    Leszczyński Dariusz

    2014-10-01

    Full Text Available Women entrepreneurship, as an object of scientific inquiries, has elicited suitable recognition among researchers during the early 1980s. However, female business owners have attracted far less attention from the academic community than their male counterparts despite their reported increasing contribution towards the economic growth of both developed and emerging nations. This article attempts to bridge this gap in knowledge by providing readers with an overview of influential international research papers that investigate some of the key issues presented in the literature about women small business management and entrepreneurship.

  6. Laboratory experiments in innovation research: A methodological overview and a review of the current literature

    OpenAIRE

    Brüggemann, Julia; Bizer, Kilian

    2016-01-01

    Innovation research has developed a broad set of methodological approaches in recent decades. In this paper, we propose laboratory experiments as a fruitful methodological addition to the existing methods in innovation research. Therefore, we provide an overview of the existing methods, discuss the advantages and limitations of laboratory experiments, and review experimental studies dealing with different fields of innovation policy, namely intellectual property rights, financi...

  7. Boolean modeling in systems biology: an overview of methodology and applications

    International Nuclear Information System (INIS)

    Wang, Rui-Sheng; Albert, Réka; Saadatpour, Assieh

    2012-01-01

    Mathematical modeling of biological processes provides deep insights into complex cellular systems. While quantitative and continuous models such as differential equations have been widely used, their use is obstructed in systems wherein the knowledge of mechanistic details and kinetic parameters is scarce. On the other hand, a wealth of molecular level qualitative data on individual components and interactions can be obtained from the experimental literature and high-throughput technologies, making qualitative approaches such as Boolean network modeling extremely useful. In this paper, we build on our research to provide a methodology overview of Boolean modeling in systems biology, including Boolean dynamic modeling of cellular networks, attractor analysis of Boolean dynamic models, as well as inferring biological regulatory mechanisms from high-throughput data using Boolean models. We finally demonstrate how Boolean models can be applied to perform the structural analysis of cellular networks. This overview aims to acquaint life science researchers with the basic steps of Boolean modeling and its applications in several areas of systems biology. (paper)

  8. Overview

    International Nuclear Information System (INIS)

    Budzanowski, A.

    2002-01-01

    Full text: In spite of rather poor financing (18% lower than in the preceding year), we ended the year 2002 with 335 scientific publications in journals listed by the Philadelphia Institute for Science Information. Our most outstanding results are given below. Further progress was achieved in the studies of the see-saw mechanism and the structure of the neutrino mass matrix. A realistic model was proposed for masses and mixing between three active neutrinos assuming a large hierarchy for the Dirac masses of neutrinos, and the degenerate mass spectrum for the right-handed Majorana masses. A natural consequence of the model is the small size of the mixing angle Θ 13 . The masses of the active neutrinos are predicted to be about 3 meV, 7 meV and 50 meV respectively. So far, the theoretical predictions have been in agreement with all recent experimental results on neutrino oscillation including the KAMLAND experiment. Successful studies contained in the area of the energy dependence of particle multiplicities in central Au + Au collisions. Similarities to particle production in the p - p and e + e - collision in a broad energy range up to 200 GeV per nucleon or lepton pair were found, what indicating a common string breaking mechanism for particle production. The dependence on pseudorapidity and centrality of the collective flow of charged particles in the Au + Au collision at √s NN = 130 GeV was determined. The importance of those quantities for testing various QCD models of heavy ion collisions was indicated. A precise test of CP violation in the process of B 0 decay to φ+K 0 S was performed using the Belle detector. Wide applicability of the thermal model of particle production in relativistic heavy ion collisions was established. Inclusion of hadron resonance decays and of the hydrodynamic flow velocity allowed us to describe cross - sections for all mesons and baryons with one freezout temperature T chemical = T kinetic = 165 MeV, which was an important result

  9. An Overview of a Continuum Mechanic Approach to a Thermodynamic Model of Failure

    National Research Council Canada - National Science Library

    Palazotto, A

    1998-01-01

    .... An overview of the thermodynamic definitions, concepts, and principles will be presented. This overview of the thermodynamics is necessary to provided the background needed to understand the damage model, which is based on thermodynamic principles...

  10. Overview

    International Nuclear Information System (INIS)

    Budzanowski, A.

    2002-01-01

    Full text: Thanks to the hard work and creativity of our scientific and technical staff, year 2001 was concluded with many exciting and promising research results. Their highlights are: The Belle experiment, running at KEKB at the High Energy Accelerator Research Organization in Tsukuba (Japan), observed the time-dependent CP violation in a neutral B-meson system. The CP violation parameter sin(2φ 1 ) was measured to be 0.99 ± 0.14 ± 0.06. The work of the Cracow group concentrated mainly on the silicon vertex detector and on the analysis of the underlying physics. New results were obtained in the field of multiparticle production in heavy-ion collisions using the PHOBOS detector installed at the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory. The pseudorapidity densities of charged particles in Au + Au collisions measured near midrapidity show an approximately logarithmic evolution over a broad range of collision energies. The measurements of antiparticle-to-particle ratios allow an estimate of the baryochemical potential, showing a closer but not yet complete approach to the baryon-free regime potential at RHIC energies. An excellent fit to the transverse momentum spectra of p; (anti)p; π + ; π - and K - ,K + up to 1.5 GeV/c within the thermal model was obtained at √s NN = 130 GeV, indicating the validity of the thermal model with expansion. Two large experiments, H1 and ZEUS, both with strong INP participation, continued their studies of e-p collisions at the HERA accelerator at DESY. For the project of the HERA collider upgrade, the Cracow ZEUS team built and installed most parts of the new luminosity detector, while the Cracow H1 group contributed to the design and development of the new software for data acquisition and on-line reconstruction. Preparations for future large experiments, ALICE, ATLAS and LHCB, at the p-p and A-A Large Hadron Collider at CERN, have continued, with strong human and financial involvement on our part

  11. Overview of climate information needs for ecological effects models

    Energy Technology Data Exchange (ETDEWEB)

    Peer, R.L.

    1990-01-01

    Atmospheric scientists engaged in climate change research require a basic understanding of how ecological effects models incorporate climate. The report provides an overview of existing ecological models that might be used to model climate change effects on vegetation. Some agricultural models and statistical methods are also discussed. The weather input data requirements, weather simulation methods, and other model characteristics relevant to climate change research are described for a selected number of models. The ecological models are classified as biome, ecosystem, or tree models; the ecosystem models are further subdivided into species dynamics or process models. In general, ecological modelers have had to rely on readily available meteorological data such as temperature and rainfall. Although models are becoming more sophisticated in their treatment of weather and require more kinds of data (such as wind, solar radiation, or potential evapotranspiration), modelers are still hampered by a lack of data for many applications. Future directions of ecological effects models and the climate variables that will be required by the models are discussed.

  12. Public Sector Reform: Which way are we headed? An overview of recent literature and research

    NARCIS (Netherlands)

    Vries, M.S. de; Nemec, J.; Spalkova, D.; Furova, L.

    2012-01-01

    This paper investigates recent literature and research on public sector reform and aims to answer the question to what degree public administration systems and reforms are still influenced by recommendations flowing from the NPM tradition. This paper distinguishes two dimensions of NPM: the internal

  13. Parent Depression and Child Anxiety: An Overview of the Literature with Clinical Implications

    Science.gov (United States)

    Colletti, Christina J. M.; Forehand, Rex; Garai, Emily; Rakow, Aaron; McKee, Laura; Fear, Jessica M.; Compas, Bruce E.

    2009-01-01

    The association of parental depression with child anxiety has received relatively little attention in the literature. In this paper we initially present several reasons for examining this relationship. We then summarize the empirical support for a link between these two variables. Finally, we discuss directions for future research and clinical…

  14. Preventing and treating intertrigo in the large skin folds of adults: a literature overview.

    NARCIS (Netherlands)

    Mistiaen, P.; Poot, E.; Hickox, S.; Jochems, C.; Wagner, C.

    2004-01-01

    Intertrigo is an inflammatory dermatosis of the skin folds of the body, for which a large variety of topical medications may be recommended. A systematic literature review was performed to find scientific evidence for preventing and treating intertrigo within the nursing domain. Seven electronic

  15. Psychological resilience and post-traumatic growth in disaster-exposed organisations: overview of the literature.

    Science.gov (United States)

    Brooks, Samantha; Amlôt, R; Rubin, G J; Greenberg, N

    2018-02-02

    As disasters become increasingly prevalent, and reported on, a wealth of literature on post-disaster mental health has been published. Most published evidence focuses on symptoms of mental health problems (such as post-traumatic stress disorder, depression and anxiety) and psychosocial factors increasing the risk of such symptoms. However, a recent shift in the literature has moved to exploring resilience and the absence of adverse lasting mental health effects following a disaster. This paper undertakes a qualitative review of the literature to explore factors affecting psychological resilience, as well as the potential positive impact of experiencing a disaster (post-traumatic growth) by examining the literature on employees in disaster-exposed organisations. We identify several protective factors: training, experience, and perceived (personal) competence; social support; and effective coping strategies. Post-traumatic growth frequently appeared to occur at both personal and professional levels for those rescue staff after a disaster, giving employees a greater appreciation of life and their relationships, enhancing their self-esteem and providing a sense of accomplishment and better understanding of their work. Implications, in terms of how to build a resilient workforce, are discussed. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  16. The Science-Technology-Society Framework for Achieving Scientific Literacy: An Overview of the Existing Literature

    Science.gov (United States)

    Autieri, Steven M.; Amirshokoohi, Aidin; Kazempour, Mahsa

    2016-01-01

    This literature review intends to highlight some of the critical research that has been synthesized on the perspectives of both teachers and students and their attitudes to teaching and learning in an STS-themed learning environment. The first portion draws on the perspectives of elementary and secondary school teachers both locally and abroad.…

  17. Mental Disorder Among Homeless Persons in the United States: An Overview of Recent Empirical Literature.

    Science.gov (United States)

    Robertson, Marjorie J.

    1986-01-01

    Reviews literature on the homeless reporting higher rates of psychiatric disorder, psychological distress, and previous psychiatric hospitalization compared to the general population. However, understandardized methodology and lack of consistent findings across studies prohibit reliable prevalence estimates of mental disorder among the homeless.…

  18. An overview of experimental results and dispersion modelling of nanoparticles in the wake of moving vehicles.

    Science.gov (United States)

    Carpentieri, Matteo; Kumar, Prashant; Robins, Alan

    2011-03-01

    Understanding the transformation of nanoparticles emitted from vehicles is essential for developing appropriate methods for treating fine scale particle dynamics in dispersion models. This article provides an overview of significant research work relevant to modelling the dispersion of pollutants, especially nanoparticles, in the wake of vehicles. Literature on vehicle wakes and nanoparticle dispersion is reviewed, taking into account field measurements, wind tunnel experiments and mathematical approaches. Field measurements and modelling studies highlighted the very short time scales associated with nanoparticle transformations in the first stages after the emission. These transformations strongly interact with the flow and turbulence fields immediately behind the vehicle, hence the need of characterising in detail the mixing processes in the vehicle wake. Very few studies have analysed this interaction and more research is needed to build a basis for model development. A possible approach is proposed and areas of further investigation identified. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. Overview of the Standard Model Measurements with the ATLAS Detector

    CERN Document Server

    Liu, Yanwen; The ATLAS collaboration

    2017-01-01

    The ATLAS Collaboration is engaged in precision measurement of fundamental Standard Model parameters, such as the W boson mass, the weak-mixing angle or the strong coupling constant. In addition, the production cross-sections of a large variety of final states involving high energetic jets, photons as well as single and multi vector bosons are measured multi differentially at several center of mass energies. This allows to test perturbative QCD calculations to highest precision. In addition, these measurements allow also to test models beyond the SM, e.g. those leading to anomalous gauge couplings. In this talk, we give a broad overview of the Standard Model measurement campaign of the ATLAS collaboration, where selected topics will be discussed in more detail.

  20. An Overview of Westinghouse Realistic Large Break LOCA Evaluation Model

    Directory of Open Access Journals (Sweden)

    Cesare Frepoli

    2008-01-01

    Full Text Available Since the 1988 amendment of the 10 CFR 50.46 rule in 1988, Westinghouse has been developing and applying realistic or best-estimate methods to perform LOCA safety analyses. A realistic analysis requires the execution of various realistic LOCA transient simulations where the effect of both model and input uncertainties are ranged and propagated throughout the transients. The outcome is typically a range of results with associated probabilities. The thermal/hydraulic code is the engine of the methodology but a procedure is developed to assess the code and determine its biases and uncertainties. In addition, inputs to the simulation are also affected by uncertainty and these uncertainties are incorporated into the process. Several approaches have been proposed and applied in the industry in the framework of best-estimate methods. Most of the implementations, including Westinghouse, follow the Code Scaling, Applicability and Uncertainty (CSAU methodology. Westinghouse methodology is based on the use of the WCOBRA/TRAC thermal-hydraulic code. The paper starts with an overview of the regulations and its interpretation in the context of realistic analysis. The CSAU roadmap is reviewed in the context of its implementation in the Westinghouse evaluation model. An overview of the code (WCOBRA/TRAC and methodology is provided. Finally, the recent evolution to nonparametric statistics in the current edition of the W methodology is discussed. Sample results of a typical large break LOCA analysis for a PWR are provided.

  1. Cancer risk diversity in non-western migrants to Europe: An overview of the literature.

    Science.gov (United States)

    Arnold, Melina; Razum, Oliver; Coebergh, Jan-Willem

    2010-09-01

    Cancer risk varies geographically and across ethnic groups that can be monitored in cancer control to respond to observed trends as well as ensure appropriate health care. The study of cancer risk in immigrant populations has great potential to contribute new insights into aetiology, diagnosis and treatment of cancer. Disparities in cancer risk patterns between immigrant and autochthonous populations have been reported many times, but up to now studies have been heterogeneous and may be discordant in their findings. The aim of this overview was to compile and compare studies on cancer occurrence in migrant populations from non-western countries residing in Western Europe in order to reflect current knowledge in this field and to appeal for further research and culturally sensitive prevention strategies. We included 37 studies published in the English language between 1990 and April 2010 focussing on cancer in adult migrants from non-western countries, living in the industrialised countries of the European Union. Migrants were defined based on their country of birth, ethnicity and name-based approaches. We conducted a between-country comparison of age-adjusted cancer incidence and mortality in immigrant populations with those in autochthonous populations. Across the board migrants from non-western countries showed a more favourable all-cancer morbidity and mortality compared with native populations of European host countries, but with considerable site-specific risk diversity: Migrants from non-western countries were more prone to cancers that are related to infections experienced in early life, such as liver, cervical and stomach cancer. In contrast, migrants of non-western origin were less likely to suffer from cancers related to a western lifestyle, e.g. colorectal, breast and prostate cancer. Confirming the great cancer risk diversity in non-western migrants in and between different European countries, this overview reaffirms the importance of exposures

  2. Literature Review on Modeling Cyber Networks and Evaluating Cyber Risks.

    Energy Technology Data Exchange (ETDEWEB)

    Kelic, Andjelka; Campbell, Philip L

    2018-04-01

    The National Infrastructure Simulations and Analysis Center (NISAC) conducted a literature review on modeling cyber networks and evaluating cyber risks. The literature review explores where modeling is used in the cyber regime and ways that consequence and risk are evaluated. The relevant literature clusters in three different spaces: network security, cyber-physical, and mission assurance. In all approaches, some form of modeling is utilized at varying levels of detail, while the ability to understand consequence varies, as do interpretations of risk. This document summarizes the different literature viewpoints and explores their applicability to securing enterprise networks.

  3. Acoustic Modeling of Lightweight Structures: A Literature Review

    Science.gov (United States)

    Yang, Shasha; Shen, Cheng

    2017-10-01

    This paper gives an overview of acoustic modeling for three kinds of typical lightweight structures including double-leaf plate system, stiffened single (or double) plate and porous material. Classical models are citied to provide frame work of theoretical modeling for acoustic property of lightweight structures; important research advances derived by our research group and other authors are introduced to describe the current state of art for acoustic research. Finally, remaining problems and future research directions are concluded and prospected briefly

  4. An Overview of Key Indicators and Evaluation Tools for Assessing Housing Quality: A Literature Review

    Science.gov (United States)

    Sinha, Rajan Chandra; Sarkar, Satyaki; Mandal, Nikhil Ranjan

    2017-09-01

    The issue of the housing quality has been addressed for various stakeholders at different levels. There exist varied opinion about its measurability and possible applications. Thus the study is carried out to have an insight into the concept of housing quality and its relevance in the changing demographics, technological, socio-economic and socio-cultural conditions. This study attempts to summarize the literature that addresses past research concerned with factors related to housing quality, its measurement methodology and critically examines the broad key indicators identified to have impact upon enhancing the housing quality. This work discusses the recent techniques which are extensively used for analysis of housing quality.

  5. Commentary: The Hmong and their Perceptions about Physical Disabilities: An Overview and Review of Selected Literature

    Directory of Open Access Journals (Sweden)

    Connie Cha

    2010-01-01

    Full Text Available The Hmong are one of the fastest growing populations in Central California. Hmong refugee families arrived in Fresno in the late 1970s facing a variety of challenges regarding their traditional health beliefs and the customs of mainstream Western biomedicine. Differing and sometimes conflicting perceptions about physical disabilities have resulted in painful misunderstandings between Hmong families and Western health care providers. The aim of this paper is to present a review of some of the Hmong health belief literature concerning physical disabilities in children. It also includes commentaries from those who work with the Hmong families of physically disabled children.

  6. Accident Analysis Methods and Models — a Systematic Literature Review

    NARCIS (Netherlands)

    Wienen, Hans Christian Augustijn; Bukhsh, Faiza Allah; Vriezekolk, E.; Wieringa, Roelf J.

    2017-01-01

    As part of our co-operation with the Telecommunication Agency of the Netherlands, we want to formulate an accident analysis method and model for use in incidents in telecommunications that cause service unavailability. In order to not re-invent the wheel, we wanted to first get an overview of all

  7. Measuring and Managing Value Co-Creation Process: Overview of Existing Theoretical Models

    Directory of Open Access Journals (Sweden)

    Monika Skaržauskaitė

    2013-08-01

    Full Text Available Purpose — the article is to provide a holistic view on concept of value co-creation and existing models for measuring and managing it by conducting theoretical analysis of scientific literature sources targeting the integration of various approaches. Most important and relevant results of the literature study are presented with a focus on changed roles of organizations and consumers. This article aims at contributing theoretically to the research stream of measuring co-creation of value in order to gain knowledge for improvement of organizational performance and enabling new and innovative means of value creation. Design/methodology/approach. The nature of this research is exploratory – theoretical analysis and synthesis of scientific literature sources targeting the integration of various approaches was performed. This approach was chosen due to the absence of established theory on models of co-creation, possible uses in organizations and systematic overview of tools measuring/suggesting how to measure co-creation. Findings. While the principles of managing and measuring co-creation in regards of consumer motivation and involvement are widely researched, little attempt has been made to identify critical factors and create models dealing with organizational capabilities and managerial implications of value co-creation. Systematic analysis of literature revealed a gap not only in empirical research concerning organization’s role in co-creation process, but in theoretical and conceptual levels, too. Research limitations/implications. The limitations of this work as a literature review lies in its nature – the complete reliance on previously published research papers and the availability of these studies. For a deeper understanding of co-creation management and for developing models that can be used in real-life organizations, a broader theoretical, as well as empirical, research is necessary. Practical implications. Analysis of the

  8. Literature overview highlights lack of paediatric donation protocols but identifies common themes that could guide their development.

    Science.gov (United States)

    Vileito, A; Siebelink, M J; Verhagen, Aae

    2018-05-01

    Paediatric donation is a unique and extremely sensitive process that requires specific knowledge and competencies. Most countries use protocols for organ and tissue donation to ensure optimal care for the donor and family, but these mainly focus on adults. However, the donation process for children differs from adults in many ways. An overview of the literature was performed to identify protocols for the paediatric population. PubMed, Web of Science, EMBASE and the Internet were searched up to March 2016 for papers or other sources in English related to specific organ and tissue donation protocols for children and neonates. This comprised title, abstract and then full-text screening of relevant data. We included 12 papers and two electronic sources that were mainly from North America and Europe. Most discussed donations after cardiac death. The recurring themes included identifying potential donors, approaching parents, palliative care and collaboration with organ procurement organisations. Most papers called for paediatric donation policies to be standardised. Scientific publications in English on paediatric donation protocols are very scarce. No comprehensive paediatric donation protocol was found. We identified several recurring themes in the literature that could be used to develop such protocols. ©2018 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

  9. A Model of the Perception of Facial Expressions of Emotion by Humans: Research Overview and Perspectives.

    Science.gov (United States)

    Martinez, Aleix; Du, Shichuan

    2012-05-01

    In cognitive science and neuroscience, there have been two leading models describing how humans perceive and classify facial expressions of emotion-the continuous and the categorical model. The continuous model defines each facial expression of emotion as a feature vector in a face space. This model explains, for example, how expressions of emotion can be seen at different intensities. In contrast, the categorical model consists of C classifiers, each tuned to a specific emotion category. This model explains, among other findings, why the images in a morphing sequence between a happy and a surprise face are perceived as either happy or surprise but not something in between. While the continuous model has a more difficult time justifying this latter finding, the categorical model is not as good when it comes to explaining how expressions are recognized at different intensities or modes. Most importantly, both models have problems explaining how one can recognize combinations of emotion categories such as happily surprised versus angrily surprised versus surprise. To resolve these issues, in the past several years, we have worked on a revised model that justifies the results reported in the cognitive science and neuroscience literature. This model consists of C distinct continuous spaces. Multiple (compound) emotion categories can be recognized by linearly combining these C face spaces. The dimensions of these spaces are shown to be mostly configural. According to this model, the major task for the classification of facial expressions of emotion is precise, detailed detection of facial landmarks rather than recognition. We provide an overview of the literature justifying the model, show how the resulting model can be employed to build algorithms for the recognition of facial expression of emotion, and propose research directions in machine learning and computer vision researchers to keep pushing the state of the art in these areas. We also discuss how the model can

  10. Literature Review of Dredging Physical Models

    Science.gov (United States)

    This U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory, special report presents a review of dredging physical ...model studies with the goal of understanding the most current state of dredging physical modeling, understanding conditions of similitude used in past...studies, and determining whether the flow field around a dredging operation has been quantified. Historical physical modeling efforts have focused on

  11. Integrated assessment models of climate change. An incomplete overview

    International Nuclear Information System (INIS)

    Dowlatabadi, H.

    1995-01-01

    Integrated assessment is a trendy phrase that has recently entered the vocabulary of folks in Washington, DC and elsewhere. The novelty of the term in policy analysis and policy making circles belies the longevity of this approach in the sciences and past attempts at their application to policy issues. This paper is an attempt at providing an overview of integrated assessment with a special focus on policy motivated integrated assessments of climate change. The first section provides an introduction to integrated assessments in general, followed by a discussion of the bounds to the climate change issue. The next section is devoted to a taxonomy of the policy motivated models. Then the integrated assessment effort at Carnegie Mellon is described briefly. A perspective on the challenges ahead in successful representation of natural and social dynamics in integrated assessments of global climate change is presented in the final section. (Author)

  12. Memory for serial order across domains: An overview of the literature and directions for future research.

    Science.gov (United States)

    Hurlstone, Mark J; Hitch, Graham J; Baddeley, Alan D

    2014-03-01

    From vocabulary learning to imitating sequences of motor actions, the ability to plan, represent, and recall a novel sequence of items in the correct order is fundamental for many verbal and nonverbal higher level cognitive activities. Here we review phenomena of serial order documented across the verbal, visual, and spatial short-term memory domains and interpret them with reference to the principles of serial order and ancillary assumptions instantiated in contemporary computational theories of memory for serial order. We propose that functional similarities across domains buttress the notion that verbal, visual, and spatial sequences are planned and controlled by a competitive queuing (CQ) mechanism in which items are simultaneously active in parallel and the strongest item is chosen for output. Within the verbal short-term memory CQ system, evidence suggests that serial order is represented via a primacy gradient, position marking, response suppression, and cumulative matching. Evidence further indicates that output interference operates during recall and that item similarity effects manifest during both serial order encoding and retrieval. By contrast, the principles underlying the representation of serial order in the visual and spatial CQ systems are unclear, largely because the relevant studies have yet to be performed. In the spatial domain, there is some evidence for a primacy gradient and position marking, whereas in the visual domain there is no direct evidence for either of the principles of serial order. We conclude by proposing some directions for future research designed to bridge this and other theoretical gaps in the literature.

  13. Socio-demographic factors and the prevalence of burns in children: an overview of the literature.

    Science.gov (United States)

    Alnababtah, Khalid; Khan, Salim; Ashford, Robert

    2016-02-01

    In most countries, socio-demographic factors influence the incidence of burns in children. The aims of this literature review were therefore to identify which of those factors are linked to an increase in the prevalence and identify ways of enhancing burn prevention programmes and preventing practices which play a role in the occurrence of burns in children. A comprehensive search (no time limit) of primary studies, titles and abstracts was undertaken in the following electronic databases; MEDLINE, CINAHL, ERIC, Cochrane Library, PsychInfo and Google Scholar. Socio-demographic factors which were linked to an increased incidence of burns include low household income, living in deprived areas, living in rented accommodation, young mothers, single-parent families and children from ethnic minorities. The level of parental education, parental occupation, and the type and size of accommodation were also cited. A range of socio-demographic factors result in an increase in the prevalence of burns, and the risk is even greater in children who are exposed to a number of these factors. Such information will be useful for planning prevention strategies and identifying further research questions that need to be answered.

  14. Discrete Model Predictive Control-Based Maximum Power Point Tracking for PV Systems: Overview and Evaluation

    DEFF Research Database (Denmark)

    Lashab, Abderezak; Sera, Dezso; Guerrero, Josep M.

    2018-01-01

    The main objective of this work is to provide an overview and evaluation of discrete model predictive controlbased maximum power point tracking (MPPT) for PV systems. A large number of MPC based MPPT methods have been recently introduced in the literature with very promising performance, however......, an in-depth investigation and comparison of these methods have not been carried out yet. Therefore, this paper has set out to provide an in-depth analysis and evaluation of MPC based MPPT methods applied to various common power converter topologies. The performance of MPC based MPPT is directly linked...... with the converter topology, and it is also affected by the accurate determination of the converter parameters, sensitivity to converter parameter variations is also investigated. The static and dynamic performance of the trackers are assessed according to the EN 50530 standard, using detailed simulation models...

  15. An overview of international literature from cystic fibrosis registries 2. Neonatal screening and nutrition/growth.

    Science.gov (United States)

    Salvatore, Donatello; Buzzetti, Roberto; Baldo, Ermanno; Forneris, Maria Pia; Lucidi, Vincenzina; Manunza, Daniela; Marinelli, Italo; Messore, Barbara; Neri, Anna Silvia; Raia, Valeria; Furnari, Maria Lucia; Mastella, Gianni

    2010-03-01

    This is the second article related to a review of the literature based on data from national cystic fibrosis (CF) registries up to June 2008 and covering a total of 115 studies. It focuses on two topics: neonatal screening (NS) and nutritional status, with particular reference to growth. Ten papers meeting the inclusion criteria were found on the topic of NS and its impact on the course of the disease, and were analyzed according to a dedicated grid. The issue of nutrition was addressed by 14 studies, analyzed according to similar criteria. Most of the studies report benefits of early diagnosis by NS, albeit to variable degrees. The benefits were assessed in terms of better nutritional status and growth, but also in terms of lower overall morbidity rate as compared to subjects diagnosed by symptoms. The main biases of these studies, which partly undermine the validity of their results, are also analyzed. A part of our analysis on nutrition/growth is dedicated to the identification of the most suitable parameters to define malnutrition: in children older than two years the body mass index percentile (BMIp) appears to be the most sensitive and significantly associated with respiratory function. Better nutritional status and satisfactory growth appear to be associated with better lung function and lower risk of death. The relationship between nutritional status and socio-economic status is also of interest. CF registry studies support the outcome of cohort observational studies i.e. that pre-symptomatic early diagnosis is beneficial, especially in terms of nutritional status and growth. Studies on nutrition indicate that good nutritional status is associated with better respiratory function and prognosis. Regarding methods, the need emerged to manage potential biases of this kind of non randomized studies, resorting to suitable statistical techniques, such as matching and stratification and, above all, to multivariate methods able to provide estimates adjusted for the

  16. Progress and Overview on Neutronics Modelling Development in RTP

    International Nuclear Information System (INIS)

    Mohamad Hairie Rabir; Muhammad Rawi Mohamed Zin; Julia Abdul Karim

    2016-01-01

    Reactor calculation and simulation are significantly important to ensure safety and better utilization of a research reactor. The Malaysian PUSPATI TRIGA Reactor (RTP) achieved initial criticality on June 28, 1982. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes. Since early 90s, neutronics modelling were used as part of its routine in-core fuel management activities. The are several computer codes have been used in RTP since then, based on 1D neutron diffusion, 2D neutron diffusion and 3D Monte Carlo neutron transport method. This paper describes current progress and overview on neutronics modelling development in RTP. Several important parameters were analysed such as k_e_f_f, reactivity, neutron flux, power distribution, B_e_f_f, and fission product build-up for the latest core configuration. The developed core neutronics model was validated by means of comparison with experimental and measurement data. Along with the RTP core model, the calculation procedure also developed to establish better prediction capability of RTP behaviour. (author)

  17. Biokinetic models for the metabolism of uranium: an overview

    International Nuclear Information System (INIS)

    Bertelli, Luiz; Lipsztein, Joyce L.; Melo, Dunstana R.; Puerta, Anselmo; Wrenn, McDonald E.

    1997-01-01

    This work reviews the main experiments involving uranium injection and inhalation into several animal species and those associated with humans as well. The literature was carefully selected to involve the uranium intake, distribution and excretion in humans and mammals. The available biokinetic models for the uranium metabolism, proposed by ICRP in Publications 2, 30 and 69, were shortly described and tested against the data. Human data which incorporates measurements of urine, autopsy and biopsy samples were also used completing the review of models associated with the systemic part. (author). 21 refs., 4 figs

  18. Overview: early history of crop growth and photosynthesis modeling.

    Science.gov (United States)

    El-Sharkawy, Mabrouk A

    2011-02-01

    As in industrial and engineering systems, there is a need to quantitatively study and analyze the many constituents of complex natural biological systems as well as agro-ecosystems via research-based mechanistic modeling. This objective is normally addressed by developing mathematically built descriptions of multilevel biological processes to provide biologists a means to integrate quantitatively experimental research findings that might lead to a better understanding of the whole systems and their interactions with surrounding environments. Aided with the power of computational capacities associated with computer technology then available, pioneering cropping systems simulations took place in the second half of the 20th century by several research groups across continents. This overview summarizes that initial pioneering effort made to simulate plant growth and photosynthesis of crop canopies, focusing on the discovery of gaps that exist in the current scientific knowledge. Examples are given for those gaps where experimental research was needed to improve the validity and application of the constructed models, so that their benefit to mankind was enhanced. Such research necessitates close collaboration among experimentalists and model builders while adopting a multidisciplinary/inter-institutional approach. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  19. Literature Review: An Overview of Epoxy Resin Syntactic Foams with Glass Microballoons

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jennie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-03-12

    Syntactic foams are an important category of composite materials that have abundant applications in a wide variety of fields. The bulk phase of syntactic foams is a three-part epoxy resin formulation that consists of a base resin, a curative (curing agent) and a modifier (diluent and/or accelerator) [12]. These thermoset materials [12] are used frequently for their thermal stability [9], low moisture absorption and high compressive strength [10]. The characteristic feature of a syntactic foam is a network of beads that forms pores within the epoxy matrix [3]. In this review, hollow glass beads (known as glass microballoons) are considered, however, solid beads or microballoons made from materials such as ceramic, polymer or metal can also be used [3M, Peter]. The network of hollow beads forms a closed-cell foam; the term closed-cell comes from the fact that the microspheres used in the resin matrix are completely closed and filled with gas (termed hollow). In contrast, the microspheres used in open-cell foams are either not completely closed or broken so that matrix material can fill the spheres [11]. Although closed foams have been found to possess higher densities than open cell foams, their rigid structures give them superior mechanical properties [12]. Past research has extensively studied the effects that changing the volume fraction of microballoons to epoxy will have on the resulting syntactic foam [3,4,9]. In addition, published literature also explores how the microballoon wall thickness affects the final product [4,9,10]. Findings detail that indeed both the mechanical and some thermal properties of syntactic foams can be tailored to a specific application by varying either the volume fraction or the wall thickness of the microballoons used [10]. The major trends in syntactic foam research show that microballoon volume fraction has an inversely proportionate relationship to dynamic properties, while microballoon wall thickness is proportional to those

  20. Literature review on induced exposure models, Task 2 HS-270

    Science.gov (United States)

    1982-02-01

    Sections 1, 2 and 3 of this report describe the development of : induced exposure models, together with d discussion of questions : of validity. These Sections focus on the most important and : relevant results from the literature, while Appendix A c...

  1. Review of Literature for Model Assisted Probability of Detection

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ryan M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Crawford, Susan L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lareau, John P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Anderson, Michael T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-09-30

    This is a draft technical letter report for NRC client documenting a literature review of model assisted probability of detection (MAPOD) for potential application to nuclear power plant components for improvement of field NDE performance estimations.

  2. An Overview of Modeling Middle Atmospheric Odd Nitrogen

    Science.gov (United States)

    Jackman, Charles H.; Kawa, S. Randolph; Einaudi, Franco (Technical Monitor)

    2001-01-01

    Odd nitrogen (N, NO, NO2, NO3, N2O5, HNO3, HO2NO2, ClONO2, and BrONO2) constituents are important components in the control of middle atmospheric ozone. Several processes lead to the production of odd nitrogen (NO(sub y)) in the middle atmosphere (stratosphere and mesosphere) including the oxidation of nitrous oxide (N2O), lightning, downflux from the thermosphere, and energetic charged particles (e.g., galactic cosmic rays, solar proton events, and energetic electron precipitation). The dominant production mechanism of NO(sub y) in the stratosphere is N2O oxidation, although other processes contribute. Mesospheric NO(sub y) is influenced by N2O oxidation, downflux from the thermosphere, and energetic charged particles. NO(sub y) is destroyed in the middle atmosphere primarily via two processes: 1) dissociation of NO to form N and O followed by N + NO yielding N2 + O to reform even nitrogen; and 2) transport to the troposphere where HNO3 can be rapidly scavenged in water droplets and rained out of the atmosphere. There are fairly significant differences among global models that predict NO(sub y). NO(sub y) has a fairly long lifetime in the stratosphere (months to years), thus disparate transport in the models probably contributes to many of these differences. Satellite and aircraft measurement provide modeling tests of the various components of NO(sub y). Although some recent reaction rate measurements have led to improvements in model/measurement agreement, significant differences do remain. This presentation will provide an overview of several proposed sources and sinks of NO(sub y) and their regions of importance. Multi-dimensional modeling results for NO(sub y) and its components with comparisons to observations will also be presented.

  3. Positive Mathematical Programming Approaches – Recent Developments in Literature and Applied Modelling

    Directory of Open Access Journals (Sweden)

    Thomas Heckelei

    2012-05-01

    Full Text Available This paper reviews and discusses the more recent literature and application of Positive Mathematical Programming in the context of agricultural supply models. Specifically, advances in the empirical foundation of parameter specifications as well as the economic rationalisation of PMP models – both criticized in earlier reviews – are investigated. Moreover, the paper provides an overview on a larger set of models with regular/repeated policy application that apply variants of PMP. Results show that most applications today avoid arbitrary parameter specifications and rely on exogenous information on supply responses to calibrate model parameters. However, only few approaches use multiple observations to estimate parameters, which is likely due to the still considerable technical challenges associated with it. Equally, we found only limited reflection on the behavioral or technological assumptions that could rationalise the PMP model structure while still keeping the model’s advantages.

  4. Critical overview of all available animal models for abdominal wall hernia research.

    Science.gov (United States)

    Vogels, R R M; Kaufmann, R; van den Hil, L C L; van Steensel, S; Schreinemacher, M H F; Lange, J F; Bouvy, N D

    2017-10-01

    Since the introduction of the first prosthetic mesh for abdominal hernia repair, there has been a search for the "ideal mesh." The use of preclinical or animal models for assessment of necessary characteristics of new and existing meshes is an indispensable part of hernia research. Unfortunately, in our experience there is a lack of consensus among different research groups on which model to use. Therefore, we hypothesized that there is a lack of comparability within published animal research on hernia surgery due to wide range in experimental setup among different research groups. A systematic search of the literature was performed to provide a complete overview of all animal models published between 2000 and 2014. Relevant parameters on model characteristics and outcome measurement were scored on a standardized scoring sheet. Due to the wide range in different animals used, ranging from large animal models like pigs to rodents, we decided to limit the study to 168 articles concerning rat models. Within these rat models, we found wide range of baseline animal characteristics, operation techniques, and outcome measurements. Making reliable comparison of results among these studies is impossible. There is a lack of comparability among experimental hernia research, limiting the impact of this experimental research. We therefore propose the establishment of guidelines for experimental hernia research by the EHS.

  5. Smart health monitoring systems: an overview of design and modeling.

    Science.gov (United States)

    Baig, Mirza Mansoor; Gholamhosseini, Hamid

    2013-04-01

    Health monitoring systems have rapidly evolved during the past two decades and have the potential to change the way health care is currently delivered. Although smart health monitoring systems automate patient monitoring tasks and, thereby improve the patient workflow management, their efficiency in clinical settings is still debatable. This paper presents a review of smart health monitoring systems and an overview of their design and modeling. Furthermore, a critical analysis of the efficiency, clinical acceptability, strategies and recommendations on improving current health monitoring systems will be presented. The main aim is to review current state of the art monitoring systems and to perform extensive and an in-depth analysis of the findings in the area of smart health monitoring systems. In order to achieve this, over fifty different monitoring systems have been selected, categorized, classified and compared. Finally, major advances in the system design level have been discussed, current issues facing health care providers, as well as the potential challenges to health monitoring field will be identified and compared to other similar systems.

  6. 75 FR 2523 - Office of Innovation and Improvement; Overview Information; Arts in Education Model Development...

    Science.gov (United States)

    2010-01-15

    ... DEPARTMENT OF EDUCATION Office of Innovation and Improvement; Overview Information; Arts in Education Model Development and Dissemination Program; Notice Inviting Applications for New Awards for... Announcement I. Funding Opportunity Description Purpose of Program: The Arts in Education Model Development and...

  7. An overview of experimental results and dispersion modelling of nanoparticles in the wake of moving vehicles

    International Nuclear Information System (INIS)

    Carpentieri, Matteo; Kumar, Prashant; Robins, Alan

    2011-01-01

    Understanding the transformation of nanoparticles emitted from vehicles is essential for developing appropriate methods for treating fine scale particle dynamics in dispersion models. This article provides an overview of significant research work relevant to modelling the dispersion of pollutants, especially nanoparticles, in the wake of vehicles. Literature on vehicle wakes and nanoparticle dispersion is reviewed, taking into account field measurements, wind tunnel experiments and mathematical approaches. Field measurements and modelling studies highlighted the very short time scales associated with nanoparticle transformations in the first stages after the emission. These transformations strongly interact with the flow and turbulence fields immediately behind the vehicle, hence the need of characterising in detail the mixing processes in the vehicle wake. Very few studies have analysed this interaction and more research is needed to build a basis for model development. A possible approach is proposed and areas of further investigation identified. - Research highlights: → Nanoparticle emissions experience very short transformation time scales. → Vehicle wakes need to be characterised to analyse nanoparticle dispersion. → Fast response measurements of nanoparticle evolution in vehicle wakes are very rare. → Wind tunnel methodologies can be further improved to include nanoparticle dynamics. → A simple mathematical approach has been proposed for future development. - The transformation of nanoparticles and the flow characteristics in both the near and far wake regions must be understood in order to develop mathematical models.

  8. Simulation Modelling in Healthcare: An Umbrella Review of Systematic Literature Reviews.

    Science.gov (United States)

    Salleh, Syed; Thokala, Praveen; Brennan, Alan; Hughes, Ruby; Booth, Andrew

    2017-09-01

    Numerous studies examine simulation modelling in healthcare. These studies present a bewildering array of simulation techniques and applications, making it challenging to characterise the literature. The aim of this paper is to provide an overview of the level of activity of simulation modelling in healthcare and the key themes. We performed an umbrella review of systematic literature reviews of simulation modelling in healthcare. Searches were conducted of academic databases (JSTOR, Scopus, PubMed, IEEE, SAGE, ACM, Wiley Online Library, ScienceDirect) and grey literature sources, enhanced by citation searches. The articles were included if they performed a systematic review of simulation modelling techniques in healthcare. After quality assessment of all included articles, data were extracted on numbers of studies included in each review, types of applications, techniques used for simulation modelling, data sources and simulation software. The search strategy yielded a total of 117 potential articles. Following sifting, 37 heterogeneous reviews were included. Most reviews achieved moderate quality rating on a modified AMSTAR (A Measurement Tool used to Assess systematic Reviews) checklist. All the review articles described the types of applications used for simulation modelling; 15 reviews described techniques used for simulation modelling; three reviews described data sources used for simulation modelling; and six reviews described software used for simulation modelling. The remaining reviews either did not report or did not provide enough detail for the data to be extracted. Simulation modelling techniques have been used for a wide range of applications in healthcare, with a variety of software tools and data sources. The number of reviews published in recent years suggest an increased interest in simulation modelling in healthcare.

  9. Integrated Medical Model Project - Overview and Summary of Historical Application

    Science.gov (United States)

    Myers, J.; Boley, L.; Butler, D.; Foy, M.; Goodenow, D.; Griffin, D.; Keenan, A.; Kerstman, E.; Melton, S.; McGuire, K.; hide

    2015-01-01

    Introduction: The Integrated Medical Model (IMM) Project represents one aspect of NASA's Human Research Program (HRP) to quantitatively assess medical risks to astronauts for existing operational missions as well as missions associated with future exploration and commercial space flight ventures. The IMM takes a probabilistic approach to assessing the likelihood and specific outcomes of one hundred medical conditions within the envelope of accepted space flight standards of care over a selectable range of mission capabilities. A specially developed Integrated Medical Evidence Database (iMED) maintains evidence-based, organizational knowledge across a variety of data sources. Since becoming operational in 2011, version 3.0 of the IMM, the supporting iMED, and the expertise of the IMM project team have contributed to a wide range of decision and informational processes for the space medical and human research community. This presentation provides an overview of the IMM conceptual architecture and range of application through examples of actual space flight community questions posed to the IMM project. Methods: Figure 1 [see document] illustrates the IMM modeling system and scenario process. As illustrated, the IMM computational architecture is based on Probabilistic Risk Assessment techniques. Nineteen assumptions and limitations define the IMM application domain. Scenario definitions include crew medical attributes and mission specific details. The IMM forecasts probabilities of loss of crew life (LOCL), evacuation (EVAC), quality time lost during the mission, number of medical resources utilized and the number and type of medical events by combining scenario information with in-flight, analog, and terrestrial medical information stored in the iMED. In addition, the metrics provide the integrated information necessary to estimate optimized in-flight medical kit contents under constraints of mass and volume or acceptable level of mission risk. Results and Conclusions

  10. Mental Models for Mechanical Comprehension. A Review of Literature.

    Science.gov (United States)

    1986-06-01

    models, constructionism , infinirm t - ,’a f.mrfn.~ gl 19 ABSTRACT (Continue on reverse if necessary and identify by block number) 4 This literature...review describes the recent research on mental models of mechanical comprehension. Three methodological approaches ( constructionism , information...things for a teacher to do to aid students’ attempts at understanding the forces involved: 1. Prepare an engaging social context. 2. Juxtapose several

  11. Premorbid and illness-related social difficulties in eating disorders: an overview of the literature and treatment developments.

    Science.gov (United States)

    Cardi, Valentina; Tchanturia, Kate; Treasure, Janet

    2018-01-17

    Social difficulties in eating disorders can manifest as predisposing traits and premorbid difficulties, and/or as consequences of the illness. Objective The aim of this paper is to briefly review the evidence for social problems in people with eating disorders and to consider the literature on treatments that target these features. Method A narrative review of the literature was conducted. Results People with eating disorders often manifest traits, such as shyness, increased tendency to submissiveness and social comparison, and problems with peer relationships before illness onset. Further social difficulties occur as the illness develops, including impaired social cognition and increased threat sensitivity. All relationships with family, peers and therapists are compromised by these effects. Thus, social difficulties are both risk and maintaining factors of eating disorders and are suitable targets for interventions. Several forms of generic treatments (e.g. interpersonal psychotherapy, cognitive analytic therapy, focal psychodynamic therapy) have an interpersonal focus and show some efficacy. Guided self-management based on the cognitive interpersonal model of the illness and directed to both individuals and support persons have been found to improve outcomes for all parties. Adjunctive treatments that focus on specific social difficulties, such as Cognitive Remediation and Emotion Skills Training and Cognitive Bias Modification have been shown to have promise. Conclusion More work is needed to establish whether these approaches can improve on the rather disappointing outcomes that are attained by currently used treatments for eating disorders. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  12. Maturity Models in Supply Chain Sustainability: A Systematic Literature Review

    Directory of Open Access Journals (Sweden)

    Elisabete Correia

    2017-01-01

    Full Text Available A systematic literature review of supply chain maturity models with sustainability concerns is presented. The objective is to give insights into methodological issues related to maturity models, namely the research objectives; the research methods used to develop, validate and test them; the scope; and the main characteristics associated with their design. The literature review was performed based on journal articles and conference papers from 2000 to 2015 using the SCOPUS, Emerald Insight, EBSCO and Web of Science databases. Most of the analysed papers have as main objective the development of maturity models and their validation. The case study is the methodology that is most widely used by researchers to develop and validate maturity models. From the sustainability perspective, the scope of the analysed maturity models is the Triple Bottom Line (TBL and environmental dimension, focusing on a specific process (eco-design and new product development and without a broad SC perspective. The dominant characteristics associated with the design of the maturity models are the maturity grids and a continuous representation. In addition, results do not allow identifying a trend for a specific number of maturity levels. The comprehensive review, analysis, and synthesis of the maturity model literature represent an important contribution to the organization of this research area, making possible to clarify some confusion that exists about concepts, approaches and components of maturity models in sustainability. Various aspects associated with the maturity models (i.e., research objectives, research methods, scope and characteristics of the design of models are explored to contribute to the evolution and significance of this multidimensional area.

  13. Implementation of Reseptive Esteemy Approach Model in Learning Reading Literature

    Directory of Open Access Journals (Sweden)

    Titin Nurhayatin

    2017-03-01

    Full Text Available Research on the implementation of aesthetic model of receptive aesthetic approach in learning to read the literature on the background of the low quality of results and learning process of Indonesian language, especially the study of literature. Students as prospective teachers of Indonesian language are expected to have the ability to speak, have literature, and their learning in a balanced manner in accordance with the curriculum demands. This study examines the effectiveness, quality, acceptability, and sustainability of the aesthetic approach of receptions in improving students' literary skills. Based on these problems, this study is expected to produce a learning model that contributes high in improving the quality of results and the process of learning literature. This research was conducted on the students of Language Education Program, Indonesian Literature and Regional FKIP Pasundan University. The research method used is experiment with randomized type pretest-posttest control group design. Based on preliminary and final test data obtained in the experimental class the average preliminary test was 55.86 and the average final test was 76.75. From the preliminary test data in the control class the average score was 55.07 and the average final test was 68.76. These data suggest that there is a greater increase in grades in the experimental class using the aesthetic approach of the reception compared with the increase in values in the control class using a conventional approach. The results show that the aesthetic approach of receptions is more effective than the conventional approach in literary reading. Based on observations, acceptance, and views of sustainability, the aesthetic approach of receptions in literary learning is expected to be an alternative and solution in overcoming the problems of literary learning and improving the quality of Indonesian learning outcomes and learning process.

  14. Partners in Parenting : An Overview of the Literature on Parents’ and Nonparental Adults’ Perspectives on Shared Responsibilities in Childrearing

    NARCIS (Netherlands)

    Kesselring, Marije; De Winter, Micha; Van Yperen, Tom; Lecluijze, Suzanne

    2016-01-01

    The involvement of nonparental adults (NPAs) in the upbringing of children is widely considered to be important for the well-being of both children and parents. However, there has been no systematic overview of parental and nonparental perspectives toward this involvement. This study presents an

  15. Towards a product independent ERP training model: An Insight from a literature review

    Directory of Open Access Journals (Sweden)

    Seyed Mohammad Motahar

    2018-03-01

    Full Text Available ERP can be called as one of the most significant contributions of computer science and particularly information systems for the business environment which can support all complicated business process of an organisation including sale, purchase, warehouse and manufacturing into a single database. For such complex system like ERP, implementation involves much collaboration which raises the concern of the success of the project. Among most significant success and failure factors of ERP implementation cited in the literature are training and consultation. For many years the majority of ERP vendors promote their product specific training models as long-term and expensive allowing the organisation to gain knowledge of the ERP system and the way it handles the business process. However, recent studies showed that ERP training can be conducted in the short term and with minimum investment and yet to be effective. Findings triggered a signal and opened a new door for research to investigate vendor-independent training models that require limited investment in training and consultancy. This paper aims to provide an overview of the literature; highlighting the research methods and theories used by authors towards building ERP training models and methods.

  16. Patent portfolio management: literature review and a proposed model.

    Science.gov (United States)

    Conegundes De Jesus, Camila Kiyomi; Salerno, Mario Sergio

    2018-05-09

    Patents and patent portfolios are gaining attention in the last decades, from the called 'pro-patent era' to the recent billionaire transactions involving patent portfolios. The field is growing in importance, both theoretically and practically and despite having substantial literature on new product development portfolio management, we have not found an article relating this theory to patent portfolios. Areas covered: The paper develops a systematic literature review on patent portfolio management to organize the evolution and tendencies of patent portfolio management, highlighting distinctive features of patent portfolio management. Interview with IP manager of three life sciences companies, including a leading multinational group provided relevant information about patent portfolio management. Expert opinion: Based on the systematic literature review on portfolio management, more specifically, on new product development portfolio theory, and interview the paper proposes the paper proposes a reference model to manage patent portfolios. The model comprises four stages aligned with the three goals of the NPD portfolio management: 1 - Linking strategy of the Company's NPD Portfolio to Patent Portfolio; 2 - Balancing the portfolio in buckets; 3 - Patent Valuation (maximizing valuation); 4 - Regularly reviewing the patent portfolio.

  17. Reactivity and recovery from different types of work measured by catecholamines and cortisol : a systematic literature overview

    NARCIS (Netherlands)

    Sluiter, J.K; Frings-Dresen, M.H.W.; Meijman, T.F.; van der Beek, A.J.

    Objectives-To review occupational health, laboratory, and sports Literature on neuroendocrine reactivity and recovery from mental, combined mental and physical, or physical tasks. Methods-A systematic literature search was performed in eight databases. Studies with catecholamines or cortisol as

  18. Does Insulin Explain the Relation between Maternal Obesity and Poor Lactation Outcomes? An Overview of the Literature.

    Science.gov (United States)

    Nommsen-Rivers, Laurie A

    2016-03-01

    It is well established that obese women are at increased risk of delayed lactogenesis and short breastfeeding duration, but the underlying causal contributors remain unclear. This review summarizes the literature examining the role of insulin in lactation outcomes. Maternal obesity is a strong risk factor for insulin resistance and prediabetes, but until recently a direct role for insulin in milk production had not been elucidated. Over the past 6 y, studies in both animal models and humans have shown insulin-sensitive gene expression to be dramatically upregulated specifically during the lactation cycle. Insulin is now considered to play a direct role in lactation, including essential roles in secretory differentiation, secretory activation, and mature milk production. At the same time, emerging clinical research suggests an important association between suboptimal glucose tolerance and lactation difficulty. To develop effective interventions to support lactation success in obese women further research is needed to identify how, when, and for whom maternal insulin secretion and sensitivity affect lactation ability. © 2016 American Society for Nutrition.

  19. Does Insulin Explain the Relation between Maternal Obesity and Poor Lactation Outcomes? An Overview of the Literature1234

    Science.gov (United States)

    2016-01-01

    It is well established that obese women are at increased risk of delayed lactogenesis and short breastfeeding duration, but the underlying causal contributors remain unclear. This review summarizes the literature examining the role of insulin in lactation outcomes. Maternal obesity is a strong risk factor for insulin resistance and prediabetes, but until recently a direct role for insulin in milk production had not been elucidated. Over the past 6 y, studies in both animal models and humans have shown insulin-sensitive gene expression to be dramatically upregulated specifically during the lactation cycle. Insulin is now considered to play a direct role in lactation, including essential roles in secretory differentiation, secretory activation, and mature milk production. At the same time, emerging clinical research suggests an important association between suboptimal glucose tolerance and lactation difficulty. To develop effective interventions to support lactation success in obese women further research is needed to identify how, when, and for whom maternal insulin secretion and sensitivity affect lactation ability. PMID:26980825

  20. Mentoring models in neurosurgical training: Review of literature.

    Science.gov (United States)

    Akhigbe, Taiwo; Zolnourian, Ardalan; Bulters, Diederik

    2017-11-01

    Effective mentoring is an invaluable element in the development of next generation of neurosurgeons. A mentor helps to develop professional core values, technical and non-technical skills, attitudes and disposition required to be qualified and competent neurosurgeon. Giving the invaluable significance of mentoring in neurosurgery, we undertook this literature review to identify mentoring models evaluating its success and relative benefit. Literature search identified using MeSH word 'mentor', mentoring, mentorship, mentoring model, neurosurgery' in MEDLINE, EMBASE and Scopus databases from 1990 to 2016. Literature reviewed to identify status of mentoring in neurosurgery, potential barriers, pitfalls and future framework for mentoring in neurosurgery. Additional articles identified through manual search of reference lists. A total of 247 studies were obtained from electronic databases, after removing duplicates, abstracts, letters to the editor and non-neurosurgery papers. Sixteen full text articles retrieved out of which five met the inclusion criteria. Generally, there is paucity of articles regarding mentoring in neurosurgery, all included papers were written in English Language, all of them described mentoring model used including simulation, distance, collaborative, facilitative tele-mentoring and peer mentoring. Mentoring in Neurosurgery is an important aspect of personal and professional development of neurosurgical trainees, currently there is decline in traditional apprenticeship due to increase demand for modern use of specialised technology, simulation and tele-medicine in neurosurgery practice. Effective and efficient mentoring will be an interplay of six mentoring models (collaborative, facilitative, distance, simulation, tele mentoring and peer mentoring) identified. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  1. Evaporation of impact water droplets in interception processes: Historical precedence of the hypothesis and a brief literature overview

    Science.gov (United States)

    Dunkerley, David L.

    2009-10-01

    SummaryIntra-storm evaporation depths exceed post-storm evaporation depths in the interception of rainfall on plant canopies. An important fraction of the intra-storm evaporation may involve the small impact (or splash) droplets produced when raindrops, and perhaps gravity drops (drips released from plant parts), collide with wet plant surfaces. This idea has been presented as a new conception by Murakami [Murakami, S., 2006. A proposal for a new forest canopy interception mechanism: splash droplet evaporation. Journal of Hydrology 319, 72-82; Murakami, S., 2007a. Application of three canopy interception models to a young stand of Japanese cypress and interpretation in terms of interception mechanism. Journal of Hydrology 342, 305-319; Murakami, S., 2007b. A follow-up for the splash droplet evaporation hypothesis of canopy interception and remaining problems: why is humidity unsaturated during rainfall? In: Proceedings of the 20th Annual Conference. Japan Society of Hydrology and Water Resources (in Japanese). ] but was in fact advanced by Dunin [Dunin, F.X., O'Loughlin, E.M., Reyenga, W., 1988. Interception loss from eucalypt forest: lysimeter determination of hourly rates for long term evaluation. Hydrological Processes 2, 315-329] more than 20 years ago. In addition, Dunin et al. considered that canopy ventilation might be enhanced in intense rain. This note draws attention to the historical precedence of the work of Dunin et al. and also presents a short review of literature on impact droplet production, highlighting areas where data are still required for the full exploration of the role of droplet evaporation in canopy interception. Droplet production needs to be properly parameterised and included in models of interception processes and landsurface-atmosphere interactions.

  2. Hydrologic nonstationarity and extrapolating models to predict the future: overview of session and proceeding

    Directory of Open Access Journals (Sweden)

    F. H. S. Chiew

    2015-06-01

    Full Text Available This paper provides an overview of this IAHS symposium and PIAHS proceeding on "hydrologic nonstationarity and extrapolating models to predict the future". The paper provides a brief review of research on this topic, presents approaches used to account for nonstationarity when extrapolating models to predict the future, and summarises the papers in this session and proceeding.

  3. Overview of analytical models for the design of linear and planar motors

    NARCIS (Netherlands)

    Jansen, J.W.; Smeets, J.P.C.; Overboom, T.T.; Rovers, J.M.M.; Lomonova, E.A.

    2014-01-01

    In this paper, an overview of analytical techniques for the modeling of linear and planar permanent-magnet motors is given. These models can be used complementary to finite element analyses for fast evaluations of topologies, but they are indispensable for the design of magnetically levitated planar

  4. A Bibliometric Analysis and Review on Performance Modeling Literature

    Directory of Open Access Journals (Sweden)

    Barbara Livieri

    2015-04-01

    Full Text Available In management practice, performance indicators are considered as a prerequisite to make informed decisions in line with the organization’s goals. On the other hand, indicators summarizes compound phenomena in a few digits, which can induce to inadequate decisions, biased by information loss and conflicting values. Model driven approaches in enterprise engineering can be very effective to avoid these pitfalls, or to take it under control. For that reason, “performance modeling” has the numbers to play a primary role in the “model driven enterprise” scenario, together with process, information and other enterprise-related aspects. In this perspective, we propose a systematic review of the literature on performance modeling in order to retrieve, classify, and summarize existing research, identify the core authors and define areas and opportunities for future research.

  5. OVERVIEW OF THE INTERNATIONAL SYMPOSIUM “NAPOLEONIC MYTHS IN WORLD CULTURE: EPISTEMOLOGY, AXIOLOGY, AND REPRESENTATIONS IN LITERATURE, HISTORIOGRAPHY, AND ART”

    Directory of Open Access Journals (Sweden)

    Elena D. Galtsova

    2016-12-01

    Full Text Available The present publication is an overview of the international symposium “Napoleonic Myths in World Culture: Epistemology, Axiology, and Representation in Literature, Historiography, and Art,” held at IWL RAS on October 3–5, 2016. It was chaired by IWL RAS together with Pasquale Paoli Corsica University, Moscow Center of the French-Russian Studies (CEFR, Institute of World History RAS, Russian State University for the Humanities, Moscow State University, and Committee on French Literature and Intellectual Culture of the Council “History of World Literature” at RAS Presidium. Over 40 literary historians, historians, sociologists, philosophers, and art historians gave their papers at the symposium. The aim of the symposium was to study interdisciplinary representations of Napoleonic myths and detect various mechanisms that enabled transform a hero (or anti-hero of his time into a fantasy that keeps recurring in the cultural consciousness, both in the depths of the human psyche and on the surface of social life. Napoleon is a hero of a “modern myth” that developed only about two hundred years ago. Therefore, one can claim that Napoleonic myth is a myth in the process of its development. The study of the mechanisms of this process is a relevant task for the humanities. The overview discusses certain cognitive dominants that reflect contemporary tendencies of the scholarly reflection on the process of development, functioning, and spread of Napoleonic myths in the world culture of the past two centuries.

  6. Asbestos: a perspective. I. An overview. II. An annotated literature collection, 1960--1974. III. A literature compilation, 1974--1977. [Health hazards

    Energy Technology Data Exchange (ETDEWEB)

    Huff, J.E.; Hammons, A.S.; Dinger, C.Y.; Kline, B.W.; Whitfield, B.L.; Black, S.A.

    1978-03-01

    Although the general population is widely exposed to asbestos, both by inhalation and ingestion, the hazards of chronic, environmental exposure have not been determined. Reasons conflict but are attributed in part to a paucity of information on human dose response, effects of asbestos ingestion, ambient concentrations and distribution of asbestos in the environment, the environmental cycling of asbestos, and related biological interactions including transmission through foodchains. As distilled from the world's asbestos literature, conclusions representing a majority opinion on the pathological effects of asbestos on man are summarized. (38 references.)

  7. The RHIC/AGS Online Model Environment: Design and Overview

    International Nuclear Information System (INIS)

    Satogata, T.; Brown, K.; Pilat, F.; Tafti Alai, A.; Tepikian, S.; Vanzeijtz

    1999-01-01

    An integrated online modeling environment is currently under development for use by AGS and RHIC physicists and commissioners. This environment combines the modeling efforts of both groups in a CDEV[1] client-server design, providing access to expected machine optics and physics parameters based on live and design machine settings. An abstract modeling interface has been designed as a set of adapters[2] around core computational modeling engines such as MAD and UAL/Teapot++[3]. This approach allows us to leverage existing survey, lattice, and magnet infrastructure, as well as easily incorporate new model engine developments. This paper describes the architecture of the RHIC/AGS modeling environment, including the application interface through CDEV and general tools for graphical interaction with the model using Tcl/Tk. Separate papers at this conference address the specifics of implementation and modeling experience for AGS and RHIC

  8. A brief overview of models of nucleon-induced reactions

    International Nuclear Information System (INIS)

    Carlson, B.V.

    2003-01-01

    The basic features of low to intermediate energy nucleon-induced reactions are discussed within the contexts of the optical model, the statistical model, preequilibrium and intranuclear cascade models. The calculation of cross sections and other scattering quantities are described. (author)

  9. An Overview of Intellectual Property and Intangible Asset Valuation Models

    Science.gov (United States)

    Matsuura, Jeffrey H.

    2004-01-01

    This paper reviews the economic models most commonly applied to estimate the value of intellectual property and other forms of intangible assets. It highlights the key strengths and weaknesses of these models. One of the apparent weaknesses of the most commonly used valuation models is the failure to incorporate legal rights into their…

  10. Computer models of vocal tract evolution: an overview and critique

    NARCIS (Netherlands)

    de Boer, B.; Fitch, W. T.

    2010-01-01

    Human speech has been investigated with computer models since the invention of digital computers, and models of the evolution of speech first appeared in the late 1960s and early 1970s. Speech science and computer models have a long shared history because speech is a physical signal and can be

  11. A Systematic Literature Review of Agile Maturity Model Research

    Directory of Open Access Journals (Sweden)

    Vaughan Henriques

    2017-02-01

    Full Text Available Background/Aim/Purpose: A commonly implemented software process improvement framework is the capability maturity model integrated (CMMI. Existing literature indicates higher levels of CMMI maturity could result in a loss of agility due to its organizational focus. To maintain agility, research has focussed attention on agile maturity models. The objective of this paper is to find the common research themes and conclusions in agile maturity model research. Methodology: This research adopts a systematic approach to agile maturity model research, using Google Scholar, Science Direct, and IEEE Xplore as sources. In total 531 articles were initially found matching the search criteria, which was filtered to 39 articles by applying specific exclusion criteria. Contribution:: The article highlights the trends in agile maturity model research, specifically bringing to light the lack of research providing validation of such models. Findings: Two major themes emerge, being the coexistence of agile and CMMI and the development of agile principle based maturity models. The research trend indicates an increase in agile maturity model articles, particularly in the latter half of the last decade, with concentrations of research coinciding with version updates of CMMI. While there is general consensus around higher CMMI maturity levels being incompatible with true agility, there is evidence of the two coexisting when agile is introduced into already highly matured environments. Future Research:\tFuture research direction for this topic should include how to attain higher levels of CMMI maturity using only agile methods, how governance is addressed in agile environments, and whether existing agile maturity models relate to improved project success.

  12. Modelling of radionuclide migration in forest ecosystems. A literature review

    Energy Technology Data Exchange (ETDEWEB)

    Avila, R.; Moberg, L.; Hubbard, L.

    1998-03-01

    The Chernobyl accident has clearly shown the long-term effects of a radioactive contamination of forest ecosystems. This report is based on a literature review of models which describe the migration of radionuclides, radioactive caesium in particular, in forest ecosystems. The report describes the particularities of the forest ecosystem, the time dynamics of the contamination, the transfer processes and factors influencing caesium migration. This provides a basis for a discussion of different approaches for modelling caesium migration in the forest. It is concluded that the studied dynamic models include the most relevant transfer processes both for the acute and the long-term phase after a radioactive deposition. However, most models are site specific and do not consider some of the factors responsible for the differences in radionuclide behaviour and distribution in different types of forests. Although model improvements are constrained by the availability of experimental data and by the lack of knowledge of the migration mechanisms some possible improvements are discussed. This report is part of the LANDSCAPE project. -An integrated approach to radionuclide flow in the semi-natural ecosystems underlying exposure pathways to man. 42 refs, 3 tabs, 9 figs.

  13. Modelling of radionuclide migration in forest ecosystems. A literature review

    International Nuclear Information System (INIS)

    Avila, R.; Moberg, L.; Hubbard, L.

    1998-03-01

    The Chernobyl accident has clearly shown the long-term effects of a radioactive contamination of forest ecosystems. This report is based on a literature review of models which describe the migration of radionuclides, radioactive caesium in particular, in forest ecosystems. The report describes the particularities of the forest ecosystem, the time dynamics of the contamination, the transfer processes and factors influencing caesium migration. This provides a basis for a discussion of different approaches for modelling caesium migration in the forest. It is concluded that the studied dynamic models include the most relevant transfer processes both for the acute and the long-term phase after a radioactive deposition. However, most models are site specific and do not consider some of the factors responsible for the differences in radionuclide behaviour and distribution in different types of forests. Although model improvements are constrained by the availability of experimental data and by the lack of knowledge of the migration mechanisms some possible improvements are discussed. This report is part of the LANDSCAPE project. -An integrated approach to radionuclide flow in the semi-natural ecosystems underlying exposure pathways to man

  14. A multidisciplinary systematic literature review on frailty: Overview of the methodology used by the Canadian Initiative on Frailty and Aging

    Directory of Open Access Journals (Sweden)

    Bergman Howard

    2009-10-01

    Full Text Available Abstract Background Over the past two decades, there has been a substantial growth in the body of literature on frailty in older persons. However, there is no consensus on its definition or the criteria used to identify frailty. In response to this lack of consensus, the Canadian Initiative on Frailty and Aging carried out a set of systematic reviews of the literature in ten areas of frailty research: biological basis; social basis; prevalence; risk factors; impact; identification; prevention and management; environment and technology; health services; health and social policy. This paper describes the methodology that was developed for the systematic reviews. Methods A Central Coordination Group (CCG was responsible for developing the methodology. This involved the development of search strategies and keywords, article selection processes, quality assessment tools, and guidelines for the synthesis of results. Each review was conducted by two experts in the content area, with the assistance of methodologists and statisticians from the CCG. Results Conducting a series of systematic literature reviews involving a range of disciplines on a concept that does not have a universally accepted definition posed several conceptual and methodological challenges. The most important conceptual challenge was determining what would qualify as literature on frailty. The methodological challenges arose from our goal of structuring a consistent methodology for reviewing literature from diverse fields of research. At the outset, certain methodological guidelines were deemed essential to ensure the validity of all the reviews. Nevertheless, it was equally important to permit flexibility in the application of the proposed methodology to capture the essence of frailty research within the given fields. Conclusion The results of these reviews allowed us to establish the status of current knowledge on frailty and promote collaboration between disciplines. Conducting

  15. Quality management using model-driven engineering: an overview

    OpenAIRE

    Ruiz-Rube, Iván; Escalona, María José

    2014-01-01

    Quality Management (QM) is one of the critical points of any software development process. In recent years, several proposals have emerged on this issue, mainly with regard to maturity models, quality standards and best practices collections. Besides, Model Driven Engineering (MDE) aims to build software systems through the construction and transformation of models. However, MDE might be used for other different tasks. In this poster, we summarize the main contributions abou...

  16. Overview of geochemical modeling needs for nuclear waste management

    International Nuclear Information System (INIS)

    Isherwood, D.; Wolery, T.

    1984-01-01

    Research needs include, but are not limited to: measurement of basic thermodynamic data at elevated temperatures for species identified by modelers as potentially important; evaluation of substances which control or limit precipitation and/or nucleation kinetics; sorption studies specifically designed to provide data needed for modeling. This includes the rate of sorption, desorption, and the characterization of the solid and aqueous phases; site-mixing models and thermodynamic data for secondary minerals that form solid solutions; the development of standard techniques for measuring rate laws for precipitation and dissolution kinetics; and measurement of rate laws describing redox kinetics, dissolution, and precipitation involving aqueous species and solid phases of interest to geochemical modelers

  17. Maintenance personnel performance simulation (MAPPS) model: overview and evaluation efforts

    International Nuclear Information System (INIS)

    Knee, H.E.; Haas, P.M.; Siegel, A.I.; Bartter, W.D.; Wolf, J.J.; Ryan, T.G.

    1984-01-01

    The development of the MAPPS model has been completed and the model is currently undergoing evaluation. These efforts are addressing a number of identified issues concerning practicality, acceptability, usefulness, and validity. Preliminary analysis of the evaluation data that has been collected indicates that MAPPS will provide comprehensive and reliable data for PRA purposes and for a number of other applications. The MAPPS computer simulation model provides the user with a sophisticated tool for gaining insights into tasks performed by NPP maintenance personnel. Its wide variety of input parameters and output data makes it extremely flexible for application to a number of diverse applications. With the demonstration of favorable model evaluation results, the MAPPS model will represent a valuable source of NPP maintainer reliability data and provide PRA studies with a source of data on maintainers that has previously not existed

  18. Overview on available animal models for application in leukemia research

    International Nuclear Information System (INIS)

    Borkhardt, A.; Sanchez-Garcia, I.; Cobaleda, C.; Hauer, J.

    2015-01-01

    The term ''leukemia'' encompasses a group of diseases with a variable clinical and pathological presentation. Its cellular origin, its biology and the underlying molecular genetic alterations determine the very variable and individual disease phenotype. The focus of this review is to discuss the most important guidelines to be taken into account when we aim at developing an ''ideal'' animal model to study leukemia. The animal model should mimic all the clinical, histological and molecular genetic characteristics of the human phenotype and should be applicable as a clinically predictive model. It should achieve all the requirements to be used as a standardized model adaptive to basic research as well as to pharmaceutical practice. Furthermore it should fulfill all the criteria to investigate environmental risk factors, the role of genomic mutations and be applicable for therapeutic testing. These constraints limit the usefulness of some existing animal models, which are however very valuable for basic research. Hence in this review we will primarily focus on genetically engineered mouse models (GEMMs) to study the most frequent types of childhood leukemia. GEMMs are robust models with relatively low site specific variability and which can, with the help of the latest gene modulating tools be adapted to individual clinical and research questions. Moreover they offer the possibility to restrict oncogene expression to a defined target population and regulate its expression level as well as its timely activity. Until recently it was only possible in individual cases to develop a murin model, which fulfills the above mentioned requirements. Hence the development of new regulatory elements to control targeted oncogene expression should be priority. Tightly controlled and cell specific oncogene expression can then be combined with a knock-in approach and will depict a robust murine model, which enables almost physiologic oncogene

  19. The state-of-the-art in short-term prediction of wind power. A literature overview

    Energy Technology Data Exchange (ETDEWEB)

    Giebel, G.; Brownsword, R.; Kariniotakis, G.

    2003-08-01

    Based on an appropriate questionnaire (WP1.1) and some other works already in progress, this report details the state-of-the-art in short term prediction of wind power, mostly summarising nearly all existing literature on the topic. (au)

  20. Workforce Skills and Innovation: An Overview of Major Themes in the Literature. OECD Education Working Papers, No. 55

    Science.gov (United States)

    Toner, Phillip

    2011-01-01

    This paper provides an account of the main approaches, debates and evidence in the literature on the role of workforce skills in the innovation process in developed economies. It draws on multiple sources including the innovation studies discipline, neoclassical Human Capital theory, institutionalist labour market studies and the work organisation…

  1. Modeling and Analysis of Wrinkled Membranes: An Overview

    Science.gov (United States)

    Yang, B.; Ding, H.; Lou, M.; Fang, H.; Broduer, Steve (Technical Monitor)

    2001-01-01

    Thin-film membranes are basic elements of a variety of space inflatable/deployable structures. Wrinkling degrades the performance and reliability of these membrane structures, and hence has been a topic of continued interest. Wrinkling analysis of membranes for general geometry and arbitrary boundary conditions is quite challenging. The objective of this presentation is two-fold. Firstly, the existing models of wrinkled membranes and related numerical solution methods are reviewed. The important issues to be discussed are the capability of a membrane model to characterize taut, wrinkled and slack states of membranes in a consistent and physically reasonable manner; the ability of a wrinkling analysis method to predict the formation and growth of wrinkled regions, and to determine out-of-plane deformation and wrinkled waves; the convergence of a numerical solution method for wrinkling analysis; and the compatibility of a wrinkling analysis with general-purpose finite element codes. According to this review, several opening issues in modeling and analysis of wrinkled membranes that are to be addressed in future research are summarized, The second objective of this presentation is to discuss a newly developed membrane model of two viable parameters (2-VP model) and associated parametric finite element method (PFEM) for wrinkling analysis are introduced. The innovations and advantages of the proposed membrane model and PFEM-based wrinkling analysis are: (1) Via a unified stress-strain relation; the 2-VP model treat the taut, wrinkled, and slack states of membranes consistently; (2) The PFEM-based wrinkling analysis has guaranteed convergence; (3) The 2-VP model along with PFEM is capable of predicting membrane out-of-plane deformations; and (4) The PFEM can be integrated into any existing finite element code. Preliminary numerical examples are also included in this presentation to demonstrate the 2-VP model and PFEM-based wrinkling analysis approach.

  2. Overview of the FEP analysis approach to model development

    International Nuclear Information System (INIS)

    Bailey, L.

    1998-01-01

    This report heads a suite of documents describing the Nirex model development programme. The programme is designed to provide a clear audit trail from the identification of significant features, events and processes (FEPs) to the models and modelling processes employed within a detailed safety assessment. A five stage approach has been adopted, which provides a systematic framework for addressing uncertainty and for the documentation of all modelling decisions and assumptions. The five stages are as follows: Stage 1: EP Analysis - compilation and structuring of a FEP database; Stage 2: Scenario and Conceptual Model Development; Stage 3: Mathematical Model Development; Stage 4: Software Development; Stage 5: confidence Building. This report describes the development and structuring of a FEP database as a Master Directed Diagram (MDD) and explains how this may be used to identify different modelling scenarios, based upon the identification of scenario -defining FEPs. The methodology describes how the possible evolution of a repository system can be addressed in terms of a base scenario, a broad and reasonable representation of the 'natural' evolution of the system, and a number of variant scenarios, representing the effects of probabilistic events and processes. The MDD has been used to identify conceptual models to represent the base scenario and the interactions between these conceptual models have been systematically reviewed using a matrix diagram technique. This has led to the identification of modelling requirements for the base scenario, against which existing assessment software capabilities have been reviewed. A mechanism for combining probabilistic scenario-defining FEPs to construct multi-FEP variant scenarios has been proposed and trialled using the concept of a 'timeline', a defined sequence of events, from which consequences can be assessed. An iterative approach, based on conservative modelling principles, has been proposed for the evaluation of

  3. Overview, comparative assessment and recommendations of forecasting models for short-term water demand prediction

    CSIR Research Space (South Africa)

    Anele, AO

    2017-11-01

    Full Text Available -term water demand (STWD) forecasts. In view of this, an overview of forecasting methods for STWD prediction is presented. Based on that, a comparative assessment of the performance of alternative forecasting models from the different methods is studied. Times...

  4. Sustainable innovation, business models and economic performance: an overview

    NARCIS (Netherlands)

    Montalvo Corral, C.

    2013-01-01

    Sustainable development requires radical and systemic innovations. Such innovations can be more effectively created and studied when building on the concept of business models. This concept provides firms with a holistic framework to envision and implement sustainable innovations. For researchers,

  5. Overview of the Higgs and Standard Model physics at ATLAS

    CERN Document Server

    Vazquez Schroeder, Tamara; The ATLAS collaboration

    2018-01-01

    This talk presents selected aspects of recent physics results from the ATLAS collaboration in the Standard Model and Higgs sectors, with a focus on the recent evidence for the associated production of the Higgs boson and a top quark pair.

  6. Overview of the EPRI CONTRACTMIX model for natural gas applications

    International Nuclear Information System (INIS)

    1993-09-01

    The Contract Mix Model (CONTRACTMIX) is designed to assist gas supply planners in analyzing the costs and risks of alternative supply strategies. By explicitly incorporating uncertainty about gas demand and market conditions into the analysis, the methodology permits the analyst to compare contracting strategies on the basis of cost and risk and to assess the value of flexible strategies and contracts. The model is applicable to purchase decisions for natural gas and other fuels. CONTRACTMIX may be used at all phases of supply decision-making, from broad strategy formulation to detailed contract design and evaluation. This document introduces the prospective user to the model's capability for analysis of gas supply contracting decisions. The document describes the types of problems CONTRACTMIX is designed to address as well as the model's structure, inputs, outputs, and unique features

  7. Modeling of coupled geochemical and transport processes: An overview

    International Nuclear Information System (INIS)

    Carnahan, C.L.

    1989-10-01

    Early coupled models associated with fluid flow and solute transport have been limited by assumed conditions of constant temperature, fully saturated fluid flow, and constant pore fluid velocity. Developments including coupling of chemical reactions to variable fields of temperature and fluid flow have generated new requirements for experimental data. As the capabilities of coupled models expand, needs are created for experimental data to be used for both input and validation. 25 refs

  8. Overview of models allowing calculation of activity coefficients

    Energy Technology Data Exchange (ETDEWEB)

    Jaussaud, C.; Sorel, C

    2004-07-01

    Activity coefficients must be estimated to accurately quantify the extraction equilibrium involved in spent fuel reprocessing. For these calculations, binary data are required for each electrolyte over a concentration range sometimes exceeding the maximum solubility. The activity coefficients must be extrapolated to model the behavior of binary supersaturated aqueous solution. According to the bibliography, the most suitable models are based on the local composition concept. (authors)

  9. Experimental models of sepsis and septic shock: an overview

    Directory of Open Access Journals (Sweden)

    Garrido Alejandra G.

    2004-01-01

    Full Text Available Sepsis remains a major cause of morbidity and mortality in surgical patients and trauma victims, mainly due to sepsis-induced multiple organ dysfunction. In contrast to preclinical studies, most clinical trials of promising new treatment strategies for sepsis have fails to demonstrate efficacy. Although many reasons could account for this discrepancy, the misinterpretation of preclinical data obtained from experimental studies, and especially the use of animal models that do not adequately mimic human sepsis may have been contributing factors. In this review, the benefits and limitations of various animal models of sepsis are discussed to clarify the extend to which findings are relevant to human sepsis, particularly with respect to the subsequent design and execution of clinical trials. Such models include intravascular infusion of endotoxin or live bacteria, bacterial peritonitis, cecal ligation and perforation, soft tissue infection, pneumonia or meningitis models, using different animal species including rats, mice, rabbits, dogs, pigs, sheep and nonhuman primates. Despite several limitations, animal models remain essential in the development of all new therapies for sepsis and septic shock, because they provide fundamental information about the pharmacokinetics, toxicity, and mechanism of drug action that cannot be duplicated by other methods. New therapeutic agents should be studies in infection models, even after the initiation of the septic process. Furthermore, debility conditions need to be reproduced to avoid the exclusive use of healthy animals, which often do not represent the human septic patient.

  10. AN OVERVIEW OF REDUCED ORDER MODELING TECHNIQUES FOR SAFETY APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Mandelli, D.; Alfonsi, A.; Talbot, P.; Wang, C.; Maljovec, D.; Smith, C.; Rabiti, C.; Cogliati, J.

    2016-10-01

    The RISMC project is developing new advanced simulation-based tools to perform Computational Risk Analysis (CRA) for the existing fleet of U.S. nuclear power plants (NPPs). These tools numerically model not only the thermal-hydraulic behavior of the reactors primary and secondary systems, but also external event temporal evolution and component/system ageing. Thus, this is not only a multi-physics problem being addressed, but also a multi-scale problem (both spatial, µm-mm-m, and temporal, seconds-hours-years). As part of the RISMC CRA approach, a large amount of computationally-expensive simulation runs may be required. An important aspect is that even though computational power is growing, the overall computational cost of a RISMC analysis using brute-force methods may be not viable for certain cases. A solution that is being evaluated to assist the computational issue is the use of reduced order modeling techniques. During the FY2015, we investigated and applied reduced order modeling techniques to decrease the RISMC analysis computational cost by decreasing the number of simulation runs; for this analysis improvement we used surrogate models instead of the actual simulation codes. This article focuses on the use of reduced order modeling techniques that can be applied to RISMC analyses in order to generate, analyze, and visualize data. In particular, we focus on surrogate models that approximate the simulation results but in a much faster time (microseconds instead of hours/days).

  11. An overview of mineral dust modeling over East Asia

    Science.gov (United States)

    Chen, Siyu; Huang, Jianping; Qian, Yun; Zhao, Chun; Kang, Litai; Yang, Ben; Wang, Yong; Liu, Yuzhi; Yuan, Tiangang; Wang, Tianhe; Ma, Xiaojun; Zhang, Guolong

    2017-08-01

    East Asian dust (EAD) exerts considerable impacts on the energy balance and climate/climate change of the earth system through its influence on solar and terrestrial radiation, cloud properties, and precipitation efficiency. Providing an accurate description of the life cycle and climate effects of EAD is therefore critical to better understanding of climate change and socioeconomic development in East Asia and even worldwide. Dust modeling has undergone substantial development since the late 1990s, associated with improved understanding of the role of EAD in the earth system. Here, we review the achievements and progress made in recent decades in terms of dust modeling research, including dust emissions, long-range transport, radiative forcing (RF), and climate effects of dust particles over East Asia. Numerous efforts in dust/EAD modeling have been directed towards furnishing more sophisticated physical and chemical processes into the models on higher spatial resolutions. Meanwhile, more systematic observations and more advanced retrieval methods for instruments that address EAD related science issues have made it possible to evaluate model results and quantify the role of EAD in the earth system, and to further reduce the uncertainties in EAD simulations. Though much progress has been made, large discrepancies and knowledge gaps still exist among EAD simulations. The deficiencies and limitations that pertain to the performance of the EAD simulations referred to in the present study are also discussed.

  12. Overview of chemical modeling of nuclear waste glass dissolution

    International Nuclear Information System (INIS)

    Bourcier, W.L.

    1991-02-01

    Glass dissolution takes place through metal leaching and hydration of the glass surface accompanied by development of alternation layers of varying crystallinity. The reaction which controls the long-term glass dissolution rate appears to be surface layer dissolution. This reaction is reversible because the buildup of dissolved species in solution slows the dissolution rate due to a decreased dissolution affinity. Glass dissolution rates are therefore highly dependent on silica concentrations in solution because silica is the major component of the alteration layer. Chemical modeling of glass dissolution using reaction path computer codes has successfully been applied to short term experimental tests and used to predict long-term repository performance. Current problems and limitations of the models include a poorly defined long-term glass dissolution mechanism, the use of model parameters determined from the same experiments that the model is used to predict, and the lack of sufficient validation of key assumptions in the modeling approach. Work is in progress that addresses these issues. 41 refs., 7 figs., 2 tabs

  13. An Overview of Soil Models for Earthquake Response Analysis

    Directory of Open Access Journals (Sweden)

    Halida Yunita

    2015-01-01

    Full Text Available Earthquakes can damage thousands of buildings and infrastructure as well as cause the loss of thousands of lives. During an earthquake, the damage to buildings is mostly caused by the effect of local soil conditions. Depending on the soil type, the earthquake waves propagating from the epicenter to the ground surface will result in various behaviors of the soil. Several studies have been conducted to accurately obtain the soil response during an earthquake. The soil model used must be able to characterize the stress-strain behavior of the soil during the earthquake. This paper compares equivalent linear and nonlinear soil model responses. Analysis was performed on two soil types, Site Class D and Site Class E. An equivalent linear soil model leads to a constant value of shear modulus, while in a nonlinear soil model, the shear modulus changes constantly,depending on the stress level, and shows inelastic behavior. The results from a comparison of both soil models are displayed in the form of maximum acceleration profiles and stress-strain curves.

  14. Maternal hypothyroidism: An overview of current experimental models.

    Science.gov (United States)

    Ghanbari, Mahboubeh; Ghasemi, Asghar

    2017-10-15

    Maternal hypothyroidism (MH) is the most common cause of transient congenital hypothyroidism. Different animal models are used for assessing developmental effects of MH in offspring. The severity and status of hypothyroidism in animal models must be a reflection of the actual conditions in humans. To obtain comparable results with different clinical conditions, which lead to MH in humans, several factors have been suggested for researchers to consider before designing the experimental models. Regarding development of fetal body systems during pregnancy, interference at different times provides different results and the appropriate time for induction of hypothyroidism should be selected based on accurate time of development of the system under assessment. Other factors that should be taken into consideration include, physiological and biochemical differences between humans and other species, thyroid hormone-independent effects of anti-thyroid drugs, circadian rhythms in TSH secretion, sex differences, physical and psychological stress. This review addresses essential guidelines for selecting and managing the optimal animal model for MH as well as discussing the pros and cons of currently used models. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Overview of friction modelling in metal forming processes

    DEFF Research Database (Denmark)

    Nielsen, Chris Valentin; Bay, Niels Oluf

    2017-01-01

    In metal forming processes, friction between tool and workpiece is an important parameter influencing the material flow, surface quality and tool life. Theoretical models of friction in metal forming are based on analysis of the real contact area in tool-workpiece interfaces. Several research...... groups have studied and modelled the asperity flattening of workpiece material against tool surface in dry contact or in contact interfaces with only thin layers of lubrication with the aim to improve understanding of friction in metal forming. This paper aims at giving a review of the most important...... future work in order to advance further in modelling of real contact area in relation to implementation of frictional conditions existing finite element codes for simulation of metal forming processes. © 2017 The Authors. Published by Elsevier Ltd....

  16. An Overview of Animal Models for Arthropod-Borne Viruses.

    Science.gov (United States)

    Reynolds, Erin S; Hart, Charles E; Hermance, Meghan E; Brining, Douglas L; Thangamani, Saravanan

    2017-06-01

    Arthropod-borne viruses (arboviruses) have continued to emerge in recent years, posing a significant health threat to millions of people worldwide. The majority of arboviruses that are pathogenic to humans are transmitted by mosquitoes and ticks, but other types of arthropod vectors can also be involved in the transmission of these viruses. To alleviate the health burdens associated with arbovirus infections, it is necessary to focus today's research on disease control and therapeutic strategies. Animal models for arboviruses are valuable experimental tools that can shed light on the pathophysiology of infection and will enable the evaluation of future treatments and vaccine candidates. Ideally an animal model will closely mimic the disease manifestations observed in humans. In this review, we outline the currently available animal models for several viruses vectored by mosquitoes, ticks, and midges, for which there are no standardly available vaccines or therapeutics.

  17. Functional overview of the Production Planning Model (ProdMod)

    International Nuclear Information System (INIS)

    Gregory, M.V.; Paul, P.K.

    1995-09-01

    The Production Planning Model (ProdMod) has been developed by SRTC for use by High Level Waste Program Management and High Level Waste Engineering as a fast running, integrated, comprehensive model of the entire SRS high level waste (HLW) complex. ProdMod can simulate the response of the HLW complex from its current state to the end of tank clean-up or to any intermediate point. The present document describes the initial release of ProdMod at the end of FY95: a model version that contains all the significant elements from the High-level Waste System Plan Revision 5 and is capable of running the simulation all the way to the postulated completion of waste removal. For the scenario represented by this release, that simulates approximately 70 years of operation of the HLW complex (out to FY2065). This initial release of ProdMod will serve as the immediate starting point for the modeling of the High-Level Waste System Plan Revision 6. Thus ProdMod is expected to be in a state of continuous change and improvement.the initial goal has been to generate a simulation of the processes of interest, with the emphasis on mass and volume balances tracked throughout the HLW complex. That has been accomplished. Future development will add a set of cost equations to the process equations and extend the model for use as a linear programming (optimization) application. The goal of this later phase will be to free the ProdMod user to some extent from the need to set up detailed simulation scenarios: the model will automatically make operational choices which minimize or maximize a given objective function. Appendix A contains the source code

  18. Overview of SDCM - The Spacecraft Design and Cost Model

    Science.gov (United States)

    Ferebee, Melvin J.; Farmer, Jeffery T.; Andersen, Gregory C.; Flamm, Jeffery D.; Badi, Deborah M.

    1988-01-01

    The Spacecraft Design and Cost Model (SDCM) is a computer-aided design and analysis tool for synthesizing spacecraft configurations, integrating their subsystems, and generating information concerning on-orbit servicing and costs. SDCM uses a bottom-up method in which the cost and performance parameters for subsystem components are first calculated; the model then sums the contributions from individual components in order to obtain an estimate of sizes and costs for each candidate configuration within a selected spacecraft system. An optimum spacraft configuration can then be selected.

  19. Multilevel Modeling: Overview and Applications to Research in Counseling Psychology

    Science.gov (United States)

    Kahn, Jeffrey H.

    2011-01-01

    Multilevel modeling (MLM) is rapidly becoming the standard method of analyzing nested data, for example, data from students within multiple schools, data on multiple clients seen by a smaller number of therapists, and even longitudinal data. Although MLM analyses are likely to increase in frequency in counseling psychology research, many readers…

  20. Overview of Computer Simulation Modeling Approaches and Methods

    Science.gov (United States)

    Robert E. Manning; Robert M. Itami; David N. Cole; Randy Gimblett

    2005-01-01

    The field of simulation modeling has grown greatly with recent advances in computer hardware and software. Much of this work has involved large scientific and industrial applications for which substantial financial resources are available. However, advances in object-oriented programming and simulation methodology, concurrent with dramatic increases in computer...

  1. Modeling and simulation in tribology across scales: An overview

    DEFF Research Database (Denmark)

    Vakis, A.I.; Yastrebov, V.A.; Scheibert, J.

    2018-01-01

    theories at the nano- and micro-scales, as well as multiscale and multiphysics aspects for analytical and computational models relevant to applications spanning a variety of sectors, from automotive to biotribology and nanotechnology. Significant effort is still required to account for complementary...

  2. Overview of geochemical modeling needs for nuclear waste management

    International Nuclear Information System (INIS)

    Isherwood, D.J.; Wolery, T.J.

    1985-01-01

    Geochemical modeling needs for nuclear waste management are discussed with an emphasis on data base development and computer code. Other areas for future research include: precipitation kinetics, fixed fugacity, sorption, glasslt. slashwater interactions, redox disequilibrium and kinetics, radiolysis, solid solutions, and isotopic fractionation. 15 references

  3. An Overview of Rainfall-Runoff Model Types

    Science.gov (United States)

    This report explores rainfall-runoff models, their generation methods, and the categories under which they fall. Runoff plays an important role in the hydrological cycle by returning excess precipitation to the oceans and controlling how much water flows into stream systems. Mode...

  4. Extensions to the energy system GMM model: An overview

    International Nuclear Information System (INIS)

    Barreto, L.; Kypreos, S.

    2006-09-01

    This report describes recent extensions to the energy-systems GMM (Global Multiregional MARKAL) model undertaken by the Energy Economics Group (EEG) of the Paul Scherrer Institute (PSI) in Switzerland (hereon referred to as PSI-EEG) in the context of the SAPIENTIA project sponsored by the European Commission (DG Research) and the Swiss National Centre for Competence in Research on Climate (NCCR-Climate). GMM is a multi-regional 'bottom-up' energy-systems optimization model that endogenizes technology learning. The model has been developed and is used at PSI-EEG. The main extensions undertaken here concern the incorporation of a clusters approach to technology learning, the introduction of an improved representation of the transportation sector with emphasis on the passenger sub-sector and the implementation of marginal abatement curves for CH 4 and N 2 O, two main non-CO 2 greenhouse gases. Also, a linear representation of the atmospheric concentration of CO 2 , CH 4 and N 2 O has been included. Other changes are related to the inclusion of additional technologies for production of synthetic fuels (hydrogen and Fischer- Tropsch liquids) and the inclusion of CO 2 capture in fossil-based and biomass-based hydrogen production. Several of the developments described here follow the work of Turton and Barreto (2004, 2006) for the ERIS model at the Environmentally Compatible Energy Strategies (ECS) Program of IIASA. The remainder of this report is organized as follows. Section 2 describes the basic structure of the GMM model, the main assumptions for the scenario developed and the basic approach to endogenize technology learning in the model and examine the effects of R+D and D+D programs. Section 3 discusses the implementation of technology clusters and describes the key components chosen here. Section 4 presents the improvements to the transportation sector with emphasis on the passenger car subsector. Section 5 briefly describes the new technologies for synthetic fuel

  5. Overview of the reactor safety study consequence model

    International Nuclear Information System (INIS)

    Wall, I.B.; Yaniv, S.S.; Blond, R.M.; McGrath, P.E.; Church, H.W.; Wayland, J.R.

    1977-01-01

    The Reactor Safety Study (WASH-1400) is a comprehensive assessment of the potential risk to the public from accidents in light water power reactors. The engineering analysis of the plants is described in detail in the Reactor Safety Study: it provides an estimate of the probability versus magnitude of the release of radioactive material. The consequence model, which is the subject of this paper, describes the progression of the postulated accident after the release of the radioactive material from the containment. A brief discussion of the manner in which the consequence calculations are performed is presented. The emphasis in the description is on the models and data that differ significantly from those previously used for these types of assessments. The results of the risk calculations for 100 light water power reactors are summarized

  6. Model measurements in the cryogenic National Transonic Facility - An overview

    Science.gov (United States)

    Holmes, H. K.

    1985-01-01

    In the operation of the National Transonic Facility (NTF) higher Reynolds numbers are obtained on the basis of a utilization of low operational temperatures and high pressures. Liquid nitrogen is used as cryogenic medium, and temperatures in the range from -320 F to 160 F can be employed. A maximum pressure of 130 psi is specified, while the NTF design parameter for the Reynolds number is 120,000,000. In view of the new requirements regarding the measurement systems, major developments had to be undertaken in virtually all wind tunnel measurement areas and, in addition, some new measurement systems were needed. Attention is given to force measurement, pressure measurement, model attitude, model deformation, and the data system.

  7. An overview of EFL teacher candidates’ teaching models

    Directory of Open Access Journals (Sweden)

    Claudio Heraldo Díaz Larenas

    2009-05-01

    Full Text Available This paper identifies the EFL teaching and learning models underlying a group of ten student-teachers’ discourse who are doing their teaching internship in different schools in Concepción, Chile. These students are about to obtain their degree as High School teachers of English. They were given a Likert-like survey that contained forty statements related to the didactic components of the English teaching and learning process. Student-teachers’ responses allowed the identification of the teaching and learning models underlying the respondents’ discourse. All respondents showed a strong communicative teaching orientation that favors the development of communication and the negotiation of meaning over the study of language structures.

  8. Modeling and simulation in tribology across scales: An overview

    DEFF Research Database (Denmark)

    Vakis, A.I.; Yastrebov, V.A.; Scheibert, J.

    2018-01-01

    This review summarizes recent advances in the area of tribology based on the outcome of a Lorentz Center workshop surveying various physical, chemical and mechanical phenomena across scales. Among the main themes discussed were those of rough surface representations, the breakdown of continuum...... nonlinear effects of plasticity, adhesion, friction, wear, lubrication and surface chemistry in tribological models. For each topic, we propose some research directions....

  9. Applications of the SWAT Model Special Section: Overview and Insights.

    Science.gov (United States)

    Gassman, Philip W; Sadeghi, Ali M; Srinivasan, Raghavan

    2014-01-01

    The Soil and Water Assessment Tool (SWAT) model has emerged as one of the most widely used water quality watershed- and river basin-scale models worldwide, applied extensively for a broad range of hydrologic and/or environmental problems. The international use of SWAT can be attributed to its flexibility in addressing water resource problems, extensive networking via dozens of training workshops and the several international conferences that have been held during the past decade, comprehensive online documentation and supporting software, and an open source code that can be adapted by model users for specific application needs. The catalyst for this special collection of papers was the 2011 International SWAT Conference & Workshops held in Toledo, Spain, which featured over 160 scientific presentations representing SWAT applications in 37 countries. This special collection presents 22 specific SWAT-related studies, most of which were presented at the 2011 SWAT Conference; it represents SWAT applications on five different continents, with the majority of studies being conducted in Europe and North America. The papers cover a variety of topics, including hydrologic testing at a wide range of watershed scales, transport of pollutants in northern European lowland watersheds, data input and routing method effects on sediment transport, development and testing of potential new model algorithms, and description and testing of supporting software. In this introduction to the special section, we provide a synthesis of these studies within four main categories: (i) hydrologic foundations, (ii) sediment transport and routing analyses, (iii) nutrient and pesticide transport, and (iv) scenario analyses. We conclude with a brief summary of key SWAT research and development needs. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  10. An Overview of Human Figure Modeling for Army Aviation Systems

    Science.gov (United States)

    2010-04-01

    space reach and vision analyses, while others are used to examine biomechanics or strength issues, for example. Still other human figure modeling...identified that the crewstation design did not allow small pilots to reach the pedals and instrument panels. Small females were unable to view the...the ECLs; improved seat adjustment to allow access to the pedals and front instrument panels for small female aviators; and increased volume of space

  11. Estimation of Continuous Time Models in Economics: an Overview

    OpenAIRE

    Clifford R. Wymer

    2009-01-01

    The dynamics of economic behaviour is often developed in theory as a continuous time system. Rigorous estimation and testing of such systems, and the analysis of some aspects of their properties, is of particular importance in distinguishing between competing hypotheses and the resulting models. The consequences for the international economy during the past eighteen months of failures in the financial sector, and particularly the banking sector, make it essential that the dynamics of financia...

  12. Computational Modeling and Simulation of Attitude Change. Part 1, Connectionist Models and Simulations of Cognitive Dissonance: an Overview

    OpenAIRE

    Voinea, Camelia Florela

    2013-01-01

    Cognitive Dissonance Theory is considered part of the cognitive consistency theories in Social Psychology. They uncover a class of conceptual models which describe the attitude change as a cognitive consistency-seeking issue. As these conceptual models requested more complex operational expression, algebraic, mathematical and, lately, computational modeling approaches of cognitive consistency have been developed. Part 1 of this work provides an overview of the connectionist modeling of cognit...

  13. Relapse Prevention: An Overview of Marlatts Cognitive- Behavioral Model

    Directory of Open Access Journals (Sweden)

    2008-11-01

    Full Text Available Relapse prevention(RPis an important component of alcoholism treatment. The RP model proposed by Marlatt and Gordon suggests that both immediate determinants (e.g.,high- risk situations, coping skills, outcome expectancies, and the abstinence violation effect and covert antecedents (e.g., lifestyle factor and urges and cravings can contribute to relapse.The RP model also incorporates numerous specific and global intervention strategies that allow therapist and client to address each step of the relapse process. Specific interventions include identifying specific high-risk situations for each client and enhancing the client's skills for coping with those situations, increasing the client's self- efficacy, eliminating myths regarding alcohol's effects, managing lapses, and restructuring the client's perceptions of the relapse process. Global strategies comprise balancing the client's lifestyle and helping him or her develop positive addictions, employing stimulus control techniques and urgemanagement techniques, and developing relapse road maps. Several studies have provided theoretical and practical support for the RP model.

  14. Re-examining the Evidence in Radiation Dermatitis Management Literature: An Overview and a Critical Appraisal of Systematic Reviews

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Raymond Javan, E-mail: email.rchan@gmail.com [Cancer Care Services, Royal Brisbane and Women' s Hospital (Australia); School of Nursing and Midwifery, University of Queensland, and Research Centre for Clinical and Community Practice Innovation, Griffith University (Australia); Larsen, Emily; Chan, Philip [Cancer Care Services, Royal Brisbane and Women' s Hospital (Australia)

    2012-11-01

    Purpose: To provide an overview and a critical appraisal of systematic reviews (SRs) of published interventions for the prevention/management of radiation dermatitis. Methods and Materials: We searched Medline, CINAHL, Embase, and the Cochrane Library. We also manually searched through individual reference lists of potentially eligible articles and a number of key journals in the topic area. Two authors screened all potential articles and included eligible SRs. Two authors critically appraised and extracted key findings from the included reviews using AMSTAR (the measurement tool for 'assessment of multiple systematic reviews'). Results: Of 1837 potential titles, 6 SRs were included. A number of interventions have been reported to be potentially beneficial for managing radiation dermatitis. Interventions evaluated in these reviews included skin care advice, steroidal/nonsteroidal topical agents, systemic therapies, modes of radiation delivery, and dressings. However, all the included SRs reported that there is insufficient evidence supporting any single effective intervention. The methodological quality of the included studies varied, and methodological shortfalls in these reviews might create biases to the overall results or recommendations for clinical practice. Conclusions: An up-to-date high-quality SR in the prevention/management of radiation dermatitis is needed to guide practice and direction for future research. We recommend that clinicians or guideline developers critically evaluate the information of SRs in their decision making.

  15. Re-examining the Evidence in Radiation Dermatitis Management Literature: An Overview and a Critical Appraisal of Systematic Reviews

    International Nuclear Information System (INIS)

    Chan, Raymond Javan; Larsen, Emily; Chan, Philip

    2012-01-01

    Purpose: To provide an overview and a critical appraisal of systematic reviews (SRs) of published interventions for the prevention/management of radiation dermatitis. Methods and Materials: We searched Medline, CINAHL, Embase, and the Cochrane Library. We also manually searched through individual reference lists of potentially eligible articles and a number of key journals in the topic area. Two authors screened all potential articles and included eligible SRs. Two authors critically appraised and extracted key findings from the included reviews using AMSTAR (the measurement tool for “assessment of multiple systematic reviews”). Results: Of 1837 potential titles, 6 SRs were included. A number of interventions have been reported to be potentially beneficial for managing radiation dermatitis. Interventions evaluated in these reviews included skin care advice, steroidal/nonsteroidal topical agents, systemic therapies, modes of radiation delivery, and dressings. However, all the included SRs reported that there is insufficient evidence supporting any single effective intervention. The methodological quality of the included studies varied, and methodological shortfalls in these reviews might create biases to the overall results or recommendations for clinical practice. Conclusions: An up-to-date high-quality SR in the prevention/management of radiation dermatitis is needed to guide practice and direction for future research. We recommend that clinicians or guideline developers critically evaluate the information of SRs in their decision making.

  16. Existing air sparging model and literature review for the development of an air sparging optimization decision tool

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    The objectives of this Report are two-fold: (1) to provide overviews of the state-of-the-art and state-of-the-practice with respect to air sparging technology, air sparging models and related or augmentation technologies (e.g., soil vapor extraction); and (2) to provide the basis for the development of the conceptual Decision Tool. The Project Team conducted an exhaustive review of available literature. The complete listing of the documents, numbering several hundred and reviewed as a part of this task, is included in Appendix A. Even with the large amount of material written regarding the development and application of air sparging, there still are significant gaps in the technical community`s understanding of the remediation technology. The results of the literature review are provided in Section 2. In Section 3, an overview of seventeen conceptual, theoretical, mathematical and empirical models is presented. Detailed descriptions of each of the models reviewed is provided in Appendix B. Included in Appendix D is a copy of the questionnaire used to compile information about the models. The remaining sections of the document reflect the analysis and synthesis of the information gleaned during the literature and model reviews. The results of these efforts provide the basis for development of the decision tree and conceptual decision tool for determining applicability and optimization of air sparging. The preliminary decision tree and accompanying information provided in Section 6 describe a three-tiered approach for determining air sparging applicability: comparison with established scenarios; calculation of conceptual design parameters; and the conducting of pilot-scale studies to confirm applicability. The final two sections of this document provide listings of the key success factors which will be used for evaluating the utility of the Decision Tool and descriptions of potential applications for Decision Tool use.

  17. Overview: Understanding nucleation phenomena from simulations of lattice gas models

    International Nuclear Information System (INIS)

    Binder, Kurt; Virnau, Peter

    2016-01-01

    Monte Carlo simulations of homogeneous and heterogeneous nucleation in Ising/lattice gas models are reviewed with an emphasis on the general insight gained on the mechanisms by which metastable states decay. Attention is paid to the proper distinction of particles that belong to a cluster (droplet), that may trigger a nucleation event, from particles in its environment, a problem crucial near the critical point. Well below the critical point, the lattice structure causes an anisotropy of the interface tension, and hence nonspherical droplet shapes result, making the treatment nontrivial even within the conventional classical theory of homogeneous nucleation. For temperatures below the roughening transition temperature facetted crystals rather than spherical droplets result. The possibility to find nucleation barriers from a thermodynamic analysis avoiding a cluster identification on the particle level is discussed, as well as the question of curvature corrections to the interfacial tension. For the interpretation of heterogeneous nucleation at planar walls, knowledge of contact angles and line tensions is desirable, and methods to extract these quantities from simulations will be mentioned. Finally, also the problem of nucleation near the stability limit of metastable states and the significance of the spinodal curve will be discussed, in the light of simulations of Ising models with medium range interactions.

  18. Overview of thermal conductivity models of anisotropic thermal insulation materials

    Science.gov (United States)

    Skurikhin, A. V.; Kostanovsky, A. V.

    2017-11-01

    Currently, the most of existing materials and substances under elaboration are anisotropic. It makes certain difficulties in the study of heat transfer process. Thermal conductivity of the materials can be characterized by tensor of the second order. Also, the parallelism between the temperature gradient vector and the density of heat flow vector is violated in anisotropic thermal insulation materials (TIM). One of the most famous TIM is a family of integrated thermal insulation refractory material («ITIRM»). The main component ensuring its properties is the «inflated» vermiculite. Natural mineral vermiculite is ground into powder state, fired by gas burner for dehydration, and its precipitate is then compressed. The key feature of thus treated batch of vermiculite is a package structure. The properties of the material lead to a slow heating of manufactured products due to low absorption and high radiation reflection. The maximum of reflection function is referred to infrared spectral region. A review of current models of heat propagation in anisotropic thermal insulation materials is carried out, as well as analysis of their thermal and optical properties. A theoretical model, which allows to determine the heat conductivity «ITIRM», can be useful in the study of thermal characteristics such as specific heat capacity, temperature conductivity, and others. Materials as «ITIRM» can be used in the metallurgy industry, thermal energy and nuclear power-engineering.

  19. Pescara benchmark: overview of modelling, testing and identification

    International Nuclear Information System (INIS)

    Bellino, A; Garibaldi, L; Marchesiello, S; Brancaleoni, F; Gabriele, S; Spina, D; Bregant, L; Carminelli, A; Catania, G; Sorrentino, S; Di Evangelista, A; Valente, C; Zuccarino, L

    2011-01-01

    The 'Pescara benchmark' is part of the national research project 'BriViDi' (BRIdge VIbrations and DIagnosis) supported by the Italian Ministero dell'Universita e Ricerca. The project is aimed at developing an integrated methodology for the structural health evaluation of railway r/c, p/c bridges. The methodology should provide for applicability in operating conditions, easy data acquisition through common industrial instrumentation, robustness and reliability against structural and environmental uncertainties. The Pescara benchmark consisted in lab tests to get a consistent and large experimental data base and subsequent data processing. Special tests were devised to simulate the train transit effects in actual field conditions. Prestressed concrete beams of current industrial production both sound and damaged at various severity corrosion levels were tested. The results were collected either in a deterministic setting and in a form suitable to deal with experimental uncertainties. Damage identification was split in two approaches: with or without a reference model. In the first case f.e. models were used in conjunction with non conventional updating techniques. In the second case, specialized output-only identification techniques capable to deal with time-variant and possibly non linear systems were developed. The lab tests allowed validating the above approaches and the performances of classical modal based damage indicators.

  20. Gender equity and sexual and reproductive health in Eastern and Southern Africa: a critical overview of the literature

    Directory of Open Access Journals (Sweden)

    Eleanor E. MacPherson

    2014-06-01

    Full Text Available Background: Gender inequalities are important social determinants of health. We set out to critically review the literature relating to gender equity and sexual and reproductive health (SRH in Eastern and Southern Africa with the aim of identifying priorities for action. Design: During November 2011, we identified studies relating to SRH and gender equity through a comprehensive literature search. Results: We found gender inequalities to be common across a range of health issues relating to SRH with women being particularly disadvantaged. Social and biological determinants combined to increase women's vulnerability to maternal mortality, HIV, and gender-based violence. Health systems significantly disadvantaged women in terms of access to care. Men fared worse in relation to HIV testing and care with social norms leading to men presenting later for treatment. Conclusions: Gender inequity in SRH requires multiple complementary approaches to address the structural drivers of unequal health outcomes. These could include interventions that alter the structural environment in which ill-health is created. Interventions are required both within and beyond the health system.

  1. Combining literature review, acoustic mapping and in situ observations: an overview of coralligenous assemblages in Liguria (NW Mediterranean Sea

    Directory of Open Access Journals (Sweden)

    Almudena Cánovas Molina

    2016-03-01

    Full Text Available A review and update of the existing knowledge on the coralligenous assemblages of Liguria (NW Italy was conducted as an essential step towards management measures for their conservation according to the EU Marine Strategy Framework Directive. By combining a literature review, acoustic mapping and in situ observations on a geographic information systems platform, we were able to assess the distribution and heterogeneity of coralligenous assemblages and the main pressures affecting them. The reliability of the literature was previously estimated using a dependability index. The coralligenous assemblages cover an area of 130.9 ha and range from 10 to 113 m depth. Twelve different biological facies (five of them not included in the EUNIS list were identified and four main geomorphotypes (plungingcliffs, paleocliffs, rockfalls and shoals were recognized. Incident light values influenced the distribution of four facies in Portofino promontory. Pressures were found on 33% of the coralligenous assemblages investigated, mainly due to fishing activities, mass mortality events, invasive species and occasional mucilaginous events. Our results showed a high spatial, geomorphological and biological heterogeneity of coralligenous assemblages in Liguria.

  2. Medical simulation: Overview, and application to wound modelling and management

    Directory of Open Access Journals (Sweden)

    Dinker R Pai

    2012-01-01

    Full Text Available Simulation in medical education is progressing in leaps and bounds. The need for simulation in medical education and training is increasing because of a overall increase in the number of medical students vis-à-vis the availability of patients; b increasing awareness among patients of their rights and consequent increase in litigations and c tremendous improvement in simulation technology which makes simulation more and more realistic. Simulation in wound care can be divided into use of simulation in wound modelling (to test the effect of projectiles on the body and simulation for training in wound management. Though this science is still in its infancy, more and more researchers are now devising both low-technology and high-technology (virtual reality simulators in this field. It is believed that simulator training will eventually translate into better wound care in real patients, though this will be the subject of further research.

  3. Medical simulation: Overview, and application to wound modelling and management.

    Science.gov (United States)

    Pai, Dinker R; Singh, Simerjit

    2012-05-01

    Simulation in medical education is progressing in leaps and bounds. The need for simulation in medical education and training is increasing because of a) overall increase in the number of medical students vis-à-vis the availability of patients; b) increasing awareness among patients of their rights and consequent increase in litigations and c) tremendous improvement in simulation technology which makes simulation more and more realistic. Simulation in wound care can be divided into use of simulation in wound modelling (to test the effect of projectiles on the body) and simulation for training in wound management. Though this science is still in its infancy, more and more researchers are now devising both low-technology and high-technology (virtual reality) simulators in this field. It is believed that simulator training will eventually translate into better wound care in real patients, though this will be the subject of further research.

  4. Modeling the explosion-source region: An overview

    International Nuclear Information System (INIS)

    Glenn, L.A.

    1993-01-01

    The explosion-source region is defined as the region surrounding an underground explosion that cannot be described by elastic or anelastic theory. This region extends typically to ranges up to 1 km/(kt) 1/3 but for some purposes, such as yield estimation via hydrodynamic means (CORRTEX and HYDRO PLUS), the maximum range of interest is less by an order of magnitude. For the simulation or analysis of seismic signals, however, what is required is the time resolved motion and stress state at the inelastic boundary. Various analytic approximations have been made for these boundary conditions, but since they rely on near-field empirical data they cannot be expected to reliably extrapolate to different explosion sites. More important, without some knowledge of the initial energy density and the characteristics of the medium immediately surrounding the explosion, these simplified models are unable to distinguish chemical from nuclear explosions, identify cavity decoupling, or account for such phenomena as anomalous dissipation via pore collapse

  5. Technical know-how for modeling of geological environment. (1) Overview and groundwater flow modeling

    International Nuclear Information System (INIS)

    Saegusa, Hiromitsu; Takeuchi, Shinji; Maekawa, Keisuke; Osawa, Hideaki; Semba, Takeshi

    2011-01-01

    It is important for site characterization projects to manage the decision-making process with transparency and traceability and to transfer the technical know-how accumulated during the research and development to the implementing phase and to future generations. The modeling for a geological environment is to be used to synthesize investigation results. Evaluation of the impact of uncertainties in the model is important to identify and prioritize key issues for further investigations. Therefore, a plan for site characterization should be made based on the results of the modeling. The aim of this study is to support for the planning of initial surface-based site characterization based on the technical know-how accumulated from the Mizunami Underground Research Laboratory Project and the Horonobe Underground Research Laboratory Project. These projects are broad scientific studies of the deep geological environment that are a basis for research and development for the geological disposal of high-level radioactive wastes. In this study, the work-flow of the groundwater flow modeling, which is one of the geological environment models, and is to be used for setting the area for the geological environment modeling and for groundwater flow characterization, and the related decision-making process using literature data have been summarized. (author)

  6. Different Modeling Aspects and Energy Systems of Unified Power Quality Conditioner (UPQC): An Overview

    OpenAIRE

    Deshpande, Payal; Shrivastava, Amit; Khare, Anula

    2016-01-01

    Abstract: This paper highlights the classification of Unified Power Quality Conditioner (UPQC) to enhance the electric power quality at distribution levels. It aims to present a broad overview on the different possible UPQC system configurations for single-phase (two-wire) and three-phase (three-wire and four-wire) networks, different modeling approaches and backup energy storages, and recent developments in the field. It is noticed that several researchers have used different names for the U...

  7. Understanding Bilingual Education: An Overview of Key Notions in the Literature and the Implications for Chinese University EFL Education

    Science.gov (United States)

    Ping, Wang

    2017-01-01

    This article starts with a review of definitions of bilingualism. It then discusses the definition of bilingual education with its focus on the analysis of bilingual competence. It is subsequently suggested that a theoretical hard nut to be cracked in today's bilingual research is to establish the scope of discussion of bilingualism models meeting…

  8. Conformational sampling in template-free protein loop structure modeling: an overview.

    Science.gov (United States)

    Li, Yaohang

    2013-01-01

    Accurately modeling protein loops is an important step to predict three-dimensional structures as well as to understand functions of many proteins. Because of their high flexibility, modeling the three-dimensional structures of loops is difficult and is usually treated as a "mini protein folding problem" under geometric constraints. In the past decade, there has been remarkable progress in template-free loop structure modeling due to advances of computational methods as well as stably increasing number of known structures available in PDB. This mini review provides an overview on the recent computational approaches for loop structure modeling. In particular, we focus on the approaches of sampling loop conformation space, which is a critical step to obtain high resolution models in template-free methods. We review the potential energy functions for loop modeling, loop buildup mechanisms to satisfy geometric constraints, and loop conformation sampling algorithms. The recent loop modeling results are also summarized.

  9. CONFORMATIONAL SAMPLING IN TEMPLATE-FREE PROTEIN LOOP STRUCTURE MODELING: AN OVERVIEW

    Directory of Open Access Journals (Sweden)

    Yaohang Li

    2013-02-01

    Full Text Available Accurately modeling protein loops is an important step to predict three-dimensional structures as well as to understand functions of many proteins. Because of their high flexibility, modeling the three-dimensional structures of loops is difficult and is usually treated as a “mini protein folding problem” under geometric constraints. In the past decade, there has been remarkable progress in template-free loop structure modeling due to advances of computational methods as well as stably increasing number of known structures available in PDB. This mini review provides an overview on the recent computational approaches for loop structure modeling. In particular, we focus on the approaches of sampling loop conformation space, which is a critical step to obtain high resolution models in template-free methods. We review the potential energy functions for loop modeling, loop buildup mechanisms to satisfy geometric constraints, and loop conformation sampling algorithms. The recent loop modeling results are also summarized.

  10. Animal models for posttraumatic stress disorder: An overview of what is used in research.

    Science.gov (United States)

    Borghans, Bart; Homberg, Judith R

    2015-12-22

    Posttraumatic stress disorder (PTSD) is a common anxiety disorder characterised by its persistence of symptoms after a traumatic experience. Although some patients can be cured, many do not benefit enough from the psychological therapies or medication strategies used. Many researchers use animal models to learn more about the disorder and several models are available. The most-used physical stressor models are single-prolonged stress, restraint stress, foot shock, stress-enhanced fear learning, and underwater trauma. Common social stressors are housing instability, social instability, early-life stress, and social defeat. Psychological models are not as diverse and rely on controlled exposure to the test animal's natural predator. While validation of these models has been resolved with replicated symptoms using analogous stressors, translating new findings to human patients remains essential for their impact on the field. Choosing a model to experiment with can be challenging; this overview of what is possible with individual models may aid in making a decision.

  11. Wind Turbine Blockset in Matlab/Simulink. General Overview and Description of the Model

    DEFF Research Database (Denmark)

    Iov, Florin; Hansen, A. D.; Soerensen, P.

    This report presents a new developed Matlab/Simulink Toolbox for wind turbine applications. This toolbox has been developed during the research project ?Simulation Platform to model, optimize and design wind turbines? and it has been used as a general developer tool for other three simulation tools......: Saber, DIgSILENT, HAWC. The report provides first a quick overview over Matlab issues and then explains the structure of the developed toolbox. The attention in the report is mainly drawn to the description of the most important mathematical models, which have been developed in the Toolbox. Then, some...

  12. Human urine-based therapeutics in Spain from the early 20th century to the present: a historical literature overview and a present-day case study.

    Science.gov (United States)

    Vallejo, José Ramón; Aparicio Mena, Alfonso J; González, José Antonio

    2017-06-01

    Human urine is currently the subject of biomedical investigations as a potential therapeutic resource and it continues to be used in remedies in different cultures and societies, including the Spanish culture. In this study we gather etnomedical knowledge about urotherapy and determine their associated symbolisms in Spain. A literature overview and a case study were carried out to compile urine-based remedies and as a direct analysis of symbolic systems. Urotherapy is widespread in Spanish folk medicine. Among the 204 collected remedies, those related to treatment of diseases or skin conditions predominate (63%). Remedies have been reported for the treatment of skin diseases such as eczema, chloasma, alopecia, etc. to treat or alleviate burns, chilblains, wounds or skin chapping, and as a treatment of venomous bites. Most of the collected remedies have an associated naturalist symbolism, based on local traditions and the transmission of empirical initial knowledge. The use of urine in Spain is a result of the interaction of two types of practice: a local and traditional urotherapy, rural and with a utilitarian purpose, and a technical urotherapy, limited to an urban environment and a naturopathic medicine.

  13. Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature

    Science.gov (United States)

    SIFFEL, CSABA; CORREA, ADOLFO; AMAR, EMMANUELLE; BAKKER, MARIAN K.; BERMEJO-SÁNCHEZ, EVA; BIANCA, SEBASTIANO; CASTILLA, EDUARDO E.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; CSÁKY-SZUNYOGH, MELINDA; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, R. BRIAN; MARENGO, LISA K.; MASTROIACOVO, PIERPAOLO; MORGAN, MARGERY; MUTCHINICK, OSVALDO M.; PIERINI, ANNA; RISSMANN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SZABOVA, ELENA; OLNEY, RICHARD S.

    2015-01-01

    Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90–2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention. PMID:22002949

  14. Critical Infrastructure Protection and Resilience Literature Survey: Modeling and Simulation

    Science.gov (United States)

    2014-11-01

    Strategy A literature search was conducted in the Scopus , IE Compendex, Inspec and National Technical Information Service (NTIS) databases. The basic...scores should also be accompanied by a review of actual values over time wherever possible. 7.4 Sources Consulted Licensed databases: Scopus EI

  15. Modelling conventional and organic farming : a literature review

    NARCIS (Netherlands)

    Acs, S.; Berentsen, P.B.M.; Huirne, R.B.M.

    2005-01-01

    Literature shows a significant development of organic farming in Europe but with considerable differences between countries. These depend on general agricultural policy (the set of regulations and laws), specific policy incentives, and also on differences in consumer behaviour. This paper reviews

  16. Lymphocyte-based model systems for allergy research: a historic overview.

    Science.gov (United States)

    Neunkirchner, Alina; Schmetterer, Klaus G; Pickl, Winfried F

    2014-01-01

    During the last decades, a multitude of studies applying distinct in vitro and in vivo model systems have contributed greatly to our better understanding of the initiation and regulation of inflammatory processes leading to allergic diseases. Over the years, it has become evident that among lymphocytes, not only IgE-producing B cells and allergy-orchestrating CD4(+) helper cells but also cytotoxic CD8(+) T cells, γδ-T cells and innate lymphoid cells, as well as regulatory lymphocytes, might critically shape the immune response towards usually innocuous allergens. In this review, we provide a historic overview of pioneering work leading to the establishment of important lymphocyte-based model systems for allergy research. Moreover, we contrast the original findings with our currently more refined knowledge to appreciate the actual validity of the respective models and to reassess the conclusions obtained from them. Conflicting studies and interpretations are identified and discussed. The tables are intended to provide an easy overview of the field not only for scientists newly entering the field but also for the broader readership interested in updating their knowledge. Along those lines, herein we discuss in vitro and in vivo approaches to the investigation of lymphocyte effector cell activation, polarization and regulation, and describe depletion and adoptive transfer models along with gene knockout and transgenic (tg) methodologies. In addition, novel attempts to establish humanized T cell antigen receptor tg mouse models for allergy research are described and discussed. © 2014 S. Karger AG, Basel.

  17. Analysing model fit of psychometric process models: An overview, a new test and an application to the diffusion model.

    Science.gov (United States)

    Ranger, Jochen; Kuhn, Jörg-Tobias; Szardenings, Carsten

    2017-05-01

    Cognitive psychometric models embed cognitive process models into a latent trait framework in order to allow for individual differences. Due to their close relationship to the response process the models allow for profound conclusions about the test takers. However, before such a model can be used its fit has to be checked carefully. In this manuscript we give an overview over existing tests of model fit and show their relation to the generalized moment test of Newey (Econometrica, 53, 1985, 1047) and Tauchen (J. Econometrics, 30, 1985, 415). We also present a new test, the Hausman test of misspecification (Hausman, Econometrica, 46, 1978, 1251). The Hausman test consists of a comparison of two estimates of the same item parameters which should be similar if the model holds. The performance of the Hausman test is evaluated in a simulation study. In this study we illustrate its application to two popular models in cognitive psychometrics, the Q-diffusion model and the D-diffusion model (van der Maas, Molenaar, Maris, Kievit, & Boorsboom, Psychol Rev., 118, 2011, 339; Molenaar, Tuerlinckx, & van der Maas, J. Stat. Softw., 66, 2015, 1). We also compare the performance of the test to four alternative tests of model fit, namely the M 2 test (Molenaar et al., J. Stat. Softw., 66, 2015, 1), the moment test (Ranger et al., Br. J. Math. Stat. Psychol., 2016) and the test for binned time (Ranger & Kuhn, Psychol. Test. Asess. , 56, 2014b, 370). The simulation study indicates that the Hausman test is superior to the latter tests. The test closely adheres to the nominal Type I error rate and has higher power in most simulation conditions. © 2017 The British Psychological Society.

  18. Literature review of models on tire-pavement interaction noise

    Science.gov (United States)

    Li, Tan; Burdisso, Ricardo; Sandu, Corina

    2018-04-01

    Tire-pavement interaction noise (TPIN) becomes dominant at speeds above 40 km/h for passenger vehicles and 70 km/h for trucks. Several models have been developed to describe and predict the TPIN. However, these models do not fully reveal the physical mechanisms or predict TPIN accurately. It is well known that all the models have both strengths and weaknesses, and different models fit different investigation purposes or conditions. The numerous papers that present these models are widely scattered among thousands of journals, and it is difficult to get the complete picture of the status of research in this area. This review article aims at presenting the history and current state of TPIN models systematically, making it easier to identify and distribute the key knowledge and opinions, and providing insight into the future research trend in this field. In this work, over 2000 references related to TPIN were collected, and 74 models were reviewed from nearly 200 selected references; these were categorized into deterministic models (37), statistical models (18), and hybrid models (19). The sections explaining the models are self-contained with key principles, equations, and illustrations included. The deterministic models were divided into three sub-categories: conventional physics models, finite element and boundary element models, and computational fluid dynamics models; the statistical models were divided into three sub-categories: traditional regression models, principal component analysis models, and fuzzy curve-fitting models; the hybrid models were divided into three sub-categories: tire-pavement interface models, mechanism separation models, and noise propagation models. At the end of each category of models, a summary table is presented to compare these models with the key information extracted. Readers may refer to these tables to find models of their interest. The strengths and weaknesses of the models in different categories were then analyzed. Finally

  19. Wind turbine blockset in Saber. General overview and description of the models

    DEFF Research Database (Denmark)

    Iov, Florin; Timbus, Adrian Vasile; Hansen, Anca Daniela

    This report presents a new developed Saber Toolbox for wind turbine applications. This toolbox has been developed during the research project “Simulation Platform to model, optimize and design wind turbines”. The report provides a quick overview of the Saber and then explains the structure...... of this simulation package, which is different than other tools e.g. Matlab/Simulink. Then the structure of the toolbox is shown as well as the description of the developed models. The main focus here is to underline the special structure of the models, which are a mixture of Saber built-in blocks and new developed...... blocks. Since the developed models are based on Saber built-in blocks, a description of the libraries from Saber is given. Then some simulation results using the developed models are shown. Finally some general conclusions regarding this new developed Toolbox as well as some directions for future work...

  20. Wind Turbine Blockset in Saber. General Overview and Description of the Model

    DEFF Research Database (Denmark)

    Iov, Florin; Timbus, Adrian Vasile; Hansen, A. D.

    This report presents a new developed Saber Toolbox for wind turbine applications. This toolbox has been developed during the research project ?Simulation Platform to model, optimize and design wind turbines?. The report provides a quick overview of the Saber and then explains the structure...... of this simulation package, which is different than other tools e.g. Matlab/Simulink. Then the structure of the toolbox is shown as well as the description of the developed models. The main focus here is to underline the special structure of the models, which are a mixture of Saber built-in blocks and new developed...... blocks. Since the developed models are based on Saber built-in blocks, a description of the libraries from Saber is given. Then some simulation results using the developed models are shown. Finally some general conclusions regarding this new developed Toolbox as well as some directions for future work...

  1. Modelling of transport and biogeochemical processes in pollution plumes: Literature review of model development

    DEFF Research Database (Denmark)

    Brun, A.; Engesgaard, Peter Knudegaard

    2002-01-01

    A literature survey shows how biogeochemical (coupled organic and inorganic reaction processes) transport models are based on considering the complete biodegradation process as either a single- or as a two-step process. It is demonstrated that some two-step process models rely on the Partial...... Equilibrium Approach (PEA). The PEA assumes the organic degradation step, and not the electron acceptor consumption step, is rate limiting. This distinction is not possible in one-step process models, where consumption of both the electron donor and acceptor are treated kinetically. A three-dimensional, two......-step PEA model is developed. The model allows for Monod kinetics and biomass growth, features usually included only in one-step process models. The biogeochemical part of the model is tested for a batch system with degradation of organic matter under the consumption of a sequence of electron acceptors...

  2. Multi-zone thermodynamic modelling of spark-ignition engine combustion - An overview

    International Nuclear Information System (INIS)

    Verhelst, S.; Sheppard, C.G.W.

    2009-01-01

    'Multi-zone thermodynamic engine model' is a generic term adopted here for the type of model also referred to as quasi-dimensional, two-zone, three-zone, etc.; based on the laws of mass and energy conservation and using a mass burning rate sub-model (as opposed to a prescribed mass burning rate) to predict the in-cylinder pressure and temperature throughout the power cycle. Such models have been used for about three decades and provide valuable tools for rapid evaluation of the influence of key engine parameters. Numerous papers have been published on the development of models of varying complexity and their application. The current work is not intended as a comprehensive review of all these works, but presents an overview of multi-zone thermodynamic models for spark-ignition engines, their pros and cons, the model equations and sub-models used to account for various processes such as turbulent wrinkling, flame development, flame geometry, heat transfer, etc. It is suggested that some past terminology adopted to distinguish combustion models (e.g. 'entrainment' versus 'flamelet') is artificial and confusing; it can also be difficult to compare the different models used. Naturally, different models use varying underlying assumptions; however, the influence of several physical processes has frequently been incorporated into one term, not always well documented or clearly described. The authors propose a unified framework that can be used to compare different sub-models on the same basis, with particular focus on turbulent combustion models.

  3. An overview of available crop growth and yield models for studies and assessments in agriculture.

    Science.gov (United States)

    Di Paola, Arianna; Valentini, Riccardo; Santini, Monia

    2016-02-01

    The scientific community offers numerous crop models with different levels of sophistication. In such a wide range of crop models, users should have the possibility to choose the most suitable, in terms of detail, scale and representativeness, to their objectives. However, even when an appropriate choice is made, model limitations should be clarified such that modelling studies are put in the proper perspective and robust applications are achieved. This work is an overview of available models to simulate crop growth and yield. A summary matrix with more than 70 crop models is provided, storing the main model characteristics that can help users to choose the proper tool according to their purposes. Overall, we found that two main aspects of models, despite their importance, are not always clear from the published references, i.e. the versatility of the models, in terms of reliable transferability to different conditions, and the degree of complexity. Hence, the developers of models should be encouraged to pay more attention to clarifying the model limitations and limits of applicability, and users should make an effort in proper model selection, to save time often devoted to iteration of tuning steps to force an inappropriate model to be adapted to their own purpose. © 2015 Society of Chemical Industry.

  4. Experimental psychiatric illness and drug abuse models: from human to animal, an overview.

    Science.gov (United States)

    Edwards, Scott; Koob, George F

    2012-01-01

    Preclinical animal models have supported much of the recent rapid expansion of neuroscience research and have facilitated critical discoveries that undoubtedly benefit patients suffering from psychiatric disorders. This overview serves as an introduction for the following chapters describing both in vivo and in vitro preclinical models of psychiatric disease components and briefly describes models related to drug dependence and affective disorders. Although there are no perfect animal models of any psychiatric disorder, models do exist for many elements of each disease state or stage. In many cases, the development of certain models is essentially restricted to the human clinical laboratory domain for the purpose of maximizing validity, whereas the use of in vitro models may best represent an adjunctive, well-controlled means to model specific signaling mechanisms associated with psychiatric disease states. The data generated by preclinical models are only as valid as the model itself, and the development and refinement of animal models for human psychiatric disorders continues to be an important challenge. Collaborative relationships between basic neuroscience and clinical modeling could greatly benefit the development of new and better models, in addition to facilitating medications development.

  5. Computer aided system engineering and analysis (CASE/A) modeling package for ECLS systems - An overview

    Science.gov (United States)

    Dalee, Robert C.; Bacskay, Allen S.; Knox, James C.

    1990-01-01

    An overview of the CASE/A-ECLSS series modeling package is presented. CASE/A is an analytical tool that has supplied engineering productivity accomplishments during ECLSS design activities. A components verification program was performed to assure component modeling validity based on test data from the Phase II comparative test program completed at the Marshall Space Flight Center. An integrated plotting feature has been added to the program which allows the operator to analyze on-screen data trends or get hard copy plots from within the CASE/A operating environment. New command features in the areas of schematic, output, and model management, and component data editing have been incorporated to enhance the engineer's productivity during a modeling program.

  6. Micromechanical modelling of nanocrystalline and ultrafine grained metals: A short overview

    DEFF Research Database (Denmark)

    Mishnaevsky, Leon; Levashov, Evgeny

    2015-01-01

    An overview of micromechanical models of strength and deformation behaviour of nanostructured and ultrafine grained metallic materials is presented. Composite models of nanomaterials, polycrystal plasticity based models, grain boundary sliding, the effect of non-equilibrium grain boundaries...... and nanoscale properties are discussed and compared. The examples of incorporation of peculiar nanocrystalline effects (like large content of amorphous or semi-amorphous grain boundary phase, partial dislocation GB emission/glide/GB absorption based deformation mechanism, diffusion deformation, etc.......) into the continuum mechanical approach are given. The possibilities of using micromechanical models to explore the ways of the improving the properties of nanocrystalline materials by modifying their structures (e.g., dispersion strengthening, creating non-equilibrium grain boundaries, varying the grain size...

  7. Modeling cognitive behavior in nuclear power plants: An overview of contributing theoretical traditions

    International Nuclear Information System (INIS)

    Woods, D.D.; Roth, E.M.

    1986-01-01

    This paper reviews the major theoretical literatures that are relevant to modeling human cognitive activities important to nuclear power plant safety. The traditions considered include control theory, communication theory, statistical decision theory, information processing models and symbolic processing models. The review reveals a gradual convergence towards models that incorporate elements from multiple traditions. Models from the control theory tradition have gradually evolved to include rich knowledge representations borrowed from the symbolic processing work. At the same time theorists in the symbolic processing tradition are beginning to grapple with some of the critical issues involved in modeling complex real world domain

  8. An overview of computer models for pollutant transfer through the atmosphere, with special consideration for radioisotopes

    International Nuclear Information System (INIS)

    Zivanovic, M.; Djukanovic, J.; Davidovic, M.; Cekerevac, D.; Stankovic, S.

    2011-01-01

    Modern society is intrinsically connected with usage and production of radioisotopes, both for military and civilian applications. During the march of 2007, there were 443 active nuclear plants, unknown quantity of nuclear weapons and a huge number of industrial, medical and other facilities that possess and use radioisotopes for various purposes. With the widespread usage of radioisotopes, there comes a danger of accidental or planed release into the biosphere. This paper gives an overview of the models that can be used for prognosis or reconstruction of radioisotope transfer through the atmosphere in case of accidental or planned release [sr

  9. Modeling good research practices--overview: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force--1.

    Science.gov (United States)

    Caro, J Jaime; Briggs, Andrew H; Siebert, Uwe; Kuntz, Karen M

    2012-01-01

    Models--mathematical frameworks that facilitate estimation of the consequences of health care decisions--have become essential tools for health technology assessment. Evolution of the methods since the first ISPOR Modeling Task Force reported in 2003 has led to a new Task Force, jointly convened with the Society for Medical Decision Making, and this series of seven articles presents the updated recommendations for best practices in conceptualizing models; implementing state-transition approaches, discrete event simulations, or dynamic transmission models; and dealing with uncertainty and validating and reporting models transparently. This overview article introduces the work of the Task Force, provides all the recommendations, and discusses some quandaries that require further elucidation. The audience for these articles includes those who build models, stakeholders who utilize their results, and, indeed, anyone concerned with the use of models to support decision making. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  10. Modeling good research practices--overview: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-1.

    Science.gov (United States)

    Caro, J Jaime; Briggs, Andrew H; Siebert, Uwe; Kuntz, Karen M

    2012-01-01

    Models-mathematical frameworks that facilitate estimation of the consequences of health care decisions-have become essential tools for health technology assessment. Evolution of the methods since the first ISPOR modeling task force reported in 2003 has led to a new task force, jointly convened with the Society for Medical Decision Making, and this series of seven papers presents the updated recommendations for best practices in conceptualizing models; implementing state-transition approaches, discrete event simulations, or dynamic transmission models; dealing with uncertainty; and validating and reporting models transparently. This overview introduces the work of the task force, provides all the recommendations, and discusses some quandaries that require further elucidation. The audience for these papers includes those who build models, stakeholders who utilize their results, and, indeed, anyone concerned with the use of models to support decision making.

  11. S/sup 3/ Financial Projection Model: preliminary user's manual and system overview

    Energy Technology Data Exchange (ETDEWEB)

    Masso, J. F.

    1976-11-30

    The S/sup 3/ Financial Projection Model is an effort undertaken to construct a pipeline economic model in order to satisfy the requirements of the US ERDA program: Energy Study of Pipeline Transportation System. A brief outline of this process is described in Appendix A, Background on the S/sup 3/ Development of a Pipeline Economic Model. A general overview of the model is presented first to indicate the rationale underlying the model and to show the linkages between the various submodels. An understanding of the basic accounting definitions and self-evident relationships between line items in the general financial accounting reports is a prerequisite for the effective application of the model. Particular attention has been paid in this system description to defining the methods of calculations utilized by the model and to describing the optional capital investment planning techniques that may be exercised with the model. The mathematical relationships underlying various planning techniques are defined and the methods for applying these techniques are discussed with illustrations and sample input data specifications. Decision tables are used to show complex decision rules applied within the model to determine the logical flow of a particular computational routine. The complete set of source data and model options are described along with the procedures for input data preparation and actual program operation.

  12. A practitioner's guide to persuasion: an overview of 15 selected persuasion theories, models and frameworks.

    Science.gov (United States)

    Cameron, Kenzie A

    2009-03-01

    To provide a brief overview of 15 selected persuasion theories and models, and to present examples of their use in health communication research. The theories are categorized as message effects models, attitude-behavior approaches, cognitive processing theories and models, consistency theories, inoculation theory, and functional approaches. As it is often the intent of a practitioner to shape, reinforce, or change a patient's behavior, familiarity with theories of persuasion may lead to the development of novel communication approaches with existing patients. This article serves as an introductory primer to theories of persuasion with applications to health communication research. Understanding key constructs and general formulations of persuasive theories may allow practitioners to employ useful theoretical frameworks when interacting with patients.

  13. Wind Turbine Blockset in Matlab/Simulink - General overview and description of the models

    Energy Technology Data Exchange (ETDEWEB)

    Iov, F.; Hansen, A.D.; Soerensen, P.; Blaabjerg, F.

    2004-03-01

    This report presents a new developed Matlab/Simulink Toolbox for wind turbine applications. This toolbox has been developed during the research project 'Simulation Platform to model, optimize and design wind turbines' and it has been used as a general developer tool for other three simulation tools: Saber, DIgSILENT, HAWC. The report provides first a quick overview over Matlab issues and then explains the structure of the developed toolbox. The attention in the report is mainly drawn to the description of the most important mathematical models, which have been developed in the Toolbox. Then, some simulation results using the developed models are shown. Finally, some general conclusions regarding this new developed Toolbox as well as some directions for future work are made. (au)

  14. Wind turbine blockset in Matlab/Simulink. General overview and description of the models

    Energy Technology Data Exchange (ETDEWEB)

    Iov, F.; Timbus, A.V.; Hansen, A.D.; Soerensen, P.; Blaabjerg, F.

    2004-03-01

    This report presents a new developed Matlab/Simulink Toolbox for wind turbine applications. This toolbox has been developed during the research project 'Simulation Platform to model, optimize and design wind turbines' and it has been used as a general developer tool for other three simulation tools: Saber, DIgSILENT, HAWC. The report provides first a quick overview over Matlab issues and then explains the structure of the developed toolbox. The attention in the report is mainly drawn to the description of the most important mathematical models, which have been developed in the Toolbox. Then, some simulation results using the developed models are shown. Finally, some general conclusions regarding this new developed Toolbox as well as some directions for future work are made. (au)

  15. Coupled geomechanical/hydrological modeling: an overview of basalt waste isolation project studies

    International Nuclear Information System (INIS)

    Baca, R.G.; Case, J.B.; Patricio, J.G.

    1980-07-01

    Basalt Waste Isolation Project investigations of the Columbia River basalts are multi-disciplinary in nature with a broad scope spanning such areas as geology, seismology, geochemistry, hydrology, rock mechanics, and many other disciplines as well. In this paper, an overview is presented which surveys recent work on numerical modeling of geomechanical and hydrological processes in a basalt rock environment. A major objective of the ongoing numerical modeling work is to establish a predictive technology base with which to: interpret the interrelationships between geomechanical behavior of rock media, the natural hydrologic phenomena, and repository conditions; evaluate the effectiveness of preconceptual repository designs and assist in the design of in situ field testing; and assess the waste isolation capability of candidate host rocks within the Columbia River basalts. To accomplish this objective, a systems approach has been adopted which is based on the use of digital simulation models

  16. Modeling of plant in vitro cultures: overview and estimation of biotechnological processes.

    Science.gov (United States)

    Maschke, Rüdiger W; Geipel, Katja; Bley, Thomas

    2015-01-01

    Plant cell and tissue cultivations are of growing interest for the production of structurally complex and expensive plant-derived products, especially in pharmaceutical production. Problems with up-scaling, low yields, and high-priced process conditions result in an increased demand for models to provide comprehension, simulation, and optimization of production processes. In the last 25 years, many models have evolved in plant biotechnology; the majority of them are specialized models for a few selected products or nutritional conditions. In this article we review, delineate, and discuss the concepts and characteristics of the most commonly used models. Therefore, the authors focus on models for plant suspension and submerged hairy root cultures. The article includes a short overview of modeling and mathematics and integrated parameters, as well as the application scope for each model. The review is meant to help researchers better understand and utilize the numerous models published for plant cultures, and to select the most suitable model for their purposes. © 2014 Wiley Periodicals, Inc.

  17. Three Models of International Entrepreneurship – An Eclectic Meta-Theoretical Overview

    DEFF Research Database (Denmark)

    Rask, Morten; Servais, Per

    The aim of this article is to provide a comprehensive review of models used to depict infant firms that operate internationally right from or close to inception, so-called international new ventures (INVs) or born global firms that emerged in the literature in the early 1990s up until today...

  18. Organizational Frustration: A Model and Review of the Literature.

    Science.gov (United States)

    Spector, Paul E.

    1978-01-01

    This discussion is divided into four parts: (1) the definition of frustration; (2) general behavioral reactions to frustration which have implications for organizations; (3) integration of the individual behavioral reactions into a model of organizational frustration; and (4) a review of the supporting evidence for the model. (Author)

  19. Using ecosystem modelling techniques in exposure assessments of radionuclides - an overview

    International Nuclear Information System (INIS)

    Kumblad, L.

    2005-01-01

    The risk to humans from potential releases from nuclear facilities is evaluated in safety assessments. Essential components of these assessments are exposure models, which estimate the transport of radionuclides in the environment, the uptake in biota, and transfer to humans. Recently, there has been a growing concern for radiological protection of the whole environment, not only humans, and a first attempt has been to employ model approaches based on stylized environments and transfer functions to biota based exclusively on bioconcentration factors (BCF). They are generally of a non-mechanistic nature and involve no knowledge of the actual processes involved, which is a severe limitation when assessing real ecosystems. in this paper, the possibility of using an ecological modelling approach as a complement or an alternative to the use of BCF-based models is discussed. The paper gives an overview of ecological and ecosystem modelling and examples of studies where ecosystem models have been used in association to ecological risk assessment studies for other pollutants than radionuclides. It also discusses the potential to use this technique in exposure assessments of radionuclides with a few examples from the safety assessment work performed by the Swedish nuclear fuel and waste management company (SKB). Finally there is a comparison of the characteristics of ecosystem models and traditionally exposure models for radionuclides used to estimate the radionuclide exposure of biota. The evaluation of ecosystem models already applied in safety assessments has shown that the ecosystem approach is possible to use to assess exposure to biota, and that it can handle many of the modelling problems identified related to BCF-models. The findings in this paper suggest that both national and international assessment frameworks for protection of the environment from ionising radiation would benefit from striving to adopt methodologies based on ecologically sound principles and

  20. MATHEMATICAL AND COMPUTATIONAL MODELLING OF RIBOSOMAL MOVEMENT AND PROTEIN SYNTHESIS: AN OVERVIEW

    Directory of Open Access Journals (Sweden)

    Tobias von der Haar

    2012-04-01

    Full Text Available Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein. The complexity of this reaction system makes it difficult to quantitatively connect its input parameters (such as translation factor or ribosome concentrations, codon composition of the mRNA, or energy availability to output parameters (such as protein synthesis rates or ribosome densities on mRNAs. Mathematical and computational models of translation have now been used for nearly five decades to investigate translation, and to shed light on the relationship between the different reactions in the system. This review gives an overview over the principal approaches used in the modelling efforts, and summarises some of the major findings that were made.

  1. An investigation of the international literature on nurse practitioner private practice models.

    Science.gov (United States)

    Currie, J; Chiarella, M; Buckley, T

    2013-12-01

    To investigate and synthesize the international literature surrounding nurse practitioner (NP) private practice models in order to provide an exposition of commonalities and differences. NP models of service delivery have been established internationally and most are based in the public healthcare system. In recent years, opportunities for the establishment of NP private practice models have evolved, facilitated by changes in legislation and driven by identification of potential patient need. To date, NP private practice models have received less attention in the literature and, to the authors' knowledge, this is the first international investigation of NP private practice models. Integrative literature review. A literature search was undertaken in October 2012. Database sources utilized included Medical Literature Analyses and Retrieval (MEDLINE), the Cumulative Index of Nursing and Allied Health Literature (CINAHL), ProQuest, Scopus and the Cochrane Database of Systematic Reviews (CDSR). The grey literature was also searched. The following Medical Subject Headings (MeSH) and search terms used both individually and in combination included nurse practitioners; private practice; joint practice; collaboration; and insurance, health and reimbursement. Once literature had been identified, a thematic analysis was undertaken to extract themes. Thirty manuscripts and five publications from the grey literature were included in the final review. Private practice NP roles were identified in five countries, with the majority of the literature emanating from the USA. The thematic analysis resulted in the identification of five themes: reimbursement, collaborative arrangements, legislation, models of care and acceptability. Proportionally, there are very few NPs engaged in private practice internationally. The most common NP private practice models were community based, with NPs working in clinic settings, either alone or with other health professionals. Challenges in the

  2. Dynamic emulation modelling for the optimal operation of water systems: an overview

    Science.gov (United States)

    Castelletti, A.; Galelli, S.; Giuliani, M.

    2014-12-01

    Despite sustained increase in computing power over recent decades, computational limitations remain a major barrier to the effective and systematic use of large-scale, process-based simulation models in rational environmental decision-making. Whereas complex models may provide clear advantages when the goal of the modelling exercise is to enhance our understanding of the natural processes, they introduce problems of model identifiability caused by over-parameterization and suffer from high computational burden when used in management and planning problems. As a result, increasing attention is now being devoted to emulation modelling (or model reduction) as a way of overcoming these limitations. An emulation model, or emulator, is a low-order approximation of the process-based model that can be substituted for it in order to solve high resource-demanding problems. In this talk, an overview of emulation modelling within the context of the optimal operation of water systems will be provided. Particular emphasis will be given to Dynamic Emulation Modelling (DEMo), a special type of model complexity reduction in which the dynamic nature of the original process-based model is preserved, with consequent advantages in a wide range of problems, particularly feedback control problems. This will be contrasted with traditional non-dynamic emulators (e.g. response surface and surrogate models) that have been studied extensively in recent years and are mainly used for planning purposes. A number of real world numerical experiences will be used to support the discussion ranging from multi-outlet water quality control in water reservoir through erosion/sedimentation rebalancing in the operation of run-off-river power plants to salinity control in lake and reservoirs.

  3. An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure

    Institute of Scientific and Technical Information of China (English)

    María Jesús Tu(n)ón; Marcelino Alvarez; Jesús M Culebras; Javier González-Gallego

    2009-01-01

    Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy which causes multiorgan failure with an extremely high mortality rate, even if intensive care is provided. Management of severe AHF continues to be one of the most challenging problems in clinical medicine. Liver transplantation has been shown to be the most effective therapy, but the procedure is limited by shortage of donor organs. Although a number of clinical trials testing different liver assist devices are under way, these systems alone have no significant effect on patient survival and are only regarded as a useful approach to bridge patients with AHF to liver transplantation. As a result, reproducible experimental animal models resembling the clinical conditions are still needed. The three main approaches used to create an animal model for AHF are: surgical procedures, toxic liver injury and infective procedures. Most common models are based on surgical techniques (total/partial hepatectomy, complete/transient devascularization) or the use of hepatotoxic drugs (acetaminophen, galactosamine, thioacetamide, and others), and very few satisfactory viral models are available. We have recently developed a viral model of AHF by meansof the inoculation of rabbits with the virus of rabbit hemorrhagic disease. This model displays biochemical and histological characteristics, and clinical features that resemble those in human AHF. In the present article an overview is given of the most widely used animal models of AHF, and their main advantages and disadvantages are reviewed.

  4. Modeling the cosmic-ray-induced soft-error rate in integrated circuits: An overview

    International Nuclear Information System (INIS)

    Srinivasan, G.R.

    1996-01-01

    This paper is an overview of the concepts and methodologies used to predict soft-error rates (SER) due to cosmic and high-energy particle radiation in integrated circuit chips. The paper emphasizes the need for the SER simulation using the actual chip circuit model which includes device, process, and technology parameters as opposed to using either the discrete device simulation or generic circuit simulation that is commonly employed in SER modeling. Concepts such as funneling, event-by-event simulation, nuclear history files, critical charge, and charge sharing are examined. Also discussed are the relative importance of elastic and inelastic nuclear collisions, rare event statistics, and device vs. circuit simulations. The semi-empirical methodologies used in the aerospace community to arrive at SERs [also referred to as single-event upset (SEU) rates] in integrated circuit chips are reviewed. This paper is one of four in this special issue relating to SER modeling. Together, they provide a comprehensive account of this modeling effort, which has resulted in a unique modeling tool called the Soft-Error Monte Carlo Model, or SEMM

  5. Eastern European Political Socialization Modeling Research: A Literature Review

    Directory of Open Access Journals (Sweden)

    Camelia Florela Voinea

    2014-01-01

    Full Text Available This paper presents empirical modeling research on political socialization of the citizens in the new Eastern European democracies. The political socialization issue offers a comparative perspective over the modeling methodologies in analytical paradigms. Eastern European political culture research has revealed features of the electoral behavior and political participation which can be identified in different degrees in all the new democracies in the area: passivity with respect to political activity of parties, elites and institutions, political apathy or lack of reaction to anti-democratic actions, skepticism or distrust in institutions, scarce participation to social movements. Several authors explain the actual political behavior of the Eastern European citizens’ and their low social and political involvement by the (political culture heritage of the communist regimes in which they lived for a long time, and which keeps shaping their political attitudes towards the state, civil society, government and institutions. Research issues in the analysis of political participation are traditionally based on statistics analyses of empirical evidence coming from public surveys. However, scarcity ofempirical data from the communist periode with regard to (political socialization, values and beliefs represent a major obstacle towards a better understanding of the historical roots of current behaviors and attitudes. Scarcity of observational data might be overcome by computational and simulation modeling.

  6. An overview of topic modeling and its current applications in bioinformatics.

    Science.gov (United States)

    Liu, Lin; Tang, Lin; Dong, Wen; Yao, Shaowen; Zhou, Wei

    2016-01-01

    With the rapid accumulation of biological datasets, machine learning methods designed to automate data analysis are urgently needed. In recent years, so-called topic models that originated from the field of natural language processing have been receiving much attention in bioinformatics because of their interpretability. Our aim was to review the application and development of topic models for bioinformatics. This paper starts with the description of a topic model, with a focus on the understanding of topic modeling. A general outline is provided on how to build an application in a topic model and how to develop a topic model. Meanwhile, the literature on application of topic models to biological data was searched and analyzed in depth. According to the types of models and the analogy between the concept of document-topic-word and a biological object (as well as the tasks of a topic model), we categorized the related studies and provided an outlook on the use of topic models for the development of bioinformatics applications. Topic modeling is a useful method (in contrast to the traditional means of data reduction in bioinformatics) and enhances researchers' ability to interpret biological information. Nevertheless, due to the lack of topic models optimized for specific biological data, the studies on topic modeling in biological data still have a long and challenging road ahead. We believe that topic models are a promising method for various applications in bioinformatics research.

  7. Progress in sensor performance testing, modeling and range prediction using the TOD method: an overview

    Science.gov (United States)

    Bijl, Piet; Hogervorst, Maarten A.; Toet, Alexander

    2017-05-01

    The Triangle Orientation Discrimination (TOD) methodology includes i) a widely applicable, accurate end-to-end EO/IR sensor test, ii) an image-based sensor system model and iii) a Target Acquisition (TA) range model. The method has been extensively validated against TA field performance for a wide variety of well- and under-sampled imagers, systems with advanced image processing techniques such as dynamic super resolution and local adaptive contrast enhancement, and sensors showing smear or noise drift, for both static and dynamic test stimuli and as a function of target contrast. Recently, significant progress has been made in various directions. Dedicated visual and NIR test charts for lab and field testing are available and thermal test benches are on the market. Automated sensor testing using an objective synthetic human observer is within reach. Both an analytical and an image-based TOD model have recently been developed and are being implemented in the European Target Acquisition model ECOMOS and in the EOSTAR TDA. Further, the methodology is being applied for design optimization of high-end security camera systems. Finally, results from a recent perception study suggest that DRI ranges for real targets can be predicted by replacing the relevant distinctive target features by TOD test patterns of the same characteristic size and contrast, enabling a new TA modeling approach. This paper provides an overview.

  8. An Overview of Recent Advances in the Iterative Analysis of Coupled Models for Wave Propagation

    Directory of Open Access Journals (Sweden)

    D. Soares

    2014-01-01

    Full Text Available Wave propagation problems can be solved using a variety of methods. However, in many cases, the joint use of different numerical procedures to model different parts of the problem may be advisable and strategies to perform the coupling between them must be developed. Many works have been published on this subject, addressing the case of electromagnetic, acoustic, or elastic waves and making use of different strategies to perform this coupling. Both direct and iterative approaches can be used, and they may exhibit specific advantages and disadvantages. This work focuses on the use of iterative coupling schemes for the analysis of wave propagation problems, presenting an overview of the application of iterative procedures to perform the coupling between different methods. Both frequency- and time-domain analyses are addressed, and problems involving acoustic, mechanical, and electromagnetic wave propagation problems are illustrated.

  9. An Overview of Multi-Dimensional Models of the Sacramento–San Joaquin Delta

    Directory of Open Access Journals (Sweden)

    Michael L. MacWilliams

    2016-12-01

    Full Text Available doi: https://doi.org/10.15447/sfews.2016v14iss4art2Over the past 15 years, the development and application of multi-dimensional hydrodynamic models in San Francisco Bay and the Sacramento–San Joaquin Delta has transformed our ability to analyze and understand the underlying physics of the system. Initial applications of three-dimensional models focused primarily on salt intrusion, and provided a valuable resource for investigating how sea level rise and levee failures in the Delta could influence water quality in the Delta under future conditions. However, multi-dimensional models have also provided significant insights into some of the fundamental biological relationships that have shaped our thinking about the system by exploring the relationship among X2, flow, fish abundance, and the low salinity zone. Through the coupling of multi-dimensional models with wind wave and sediment transport models, it has been possible to move beyond salinity to understand how large-scale changes to the system are likely to affect sediment dynamics, and to assess the potential effects on species that rely on turbidity for habitat. Lastly, the coupling of multi-dimensional hydrodynamic models with particle tracking models has led to advances in our thinking about residence time, the retention of food organisms in the estuary, the effect of south Delta exports on larval entrainment, and the pathways and behaviors of salmonids that travel through the Delta. This paper provides an overview of these recent advances and how they have increased our understanding of the distribution and movement of fish and food organisms. The applications presented serve as a guide to the current state of the science of Delta modeling and provide examples of how we can use multi-dimensional models to predict how future Delta conditions will affect both fish and water supply.

  10. UNDERSTANDING E-COMMERCE ADOPTION. LITERATURE REVIEW OF COMPETING MODELS

    Directory of Open Access Journals (Sweden)

    Constantin SASU

    2017-05-01

    Full Text Available The present paper reviews the theory of planned behaviour (Ajzen, 1991, the theory of reasoned action (Fishbein and Ajzen, 1975; Ajzen and Fishbein, 1980 and the theory of technology acceptance model (Davis, 1989 in order to better perceive their possible future application in the marketing field, namely in the process of using electronic commerce at the organizational level. While previous empirical studies have focused primarily on one of the theories, in an attempt to rule the advantages and / or disadvantages which would support the findings and hypothesis presented, it is the authors’ belief that all three theories greatly contribute, each one in a unique way. However, several pitfalls in methodology may be encountered, therefore further empirical research is required.

  11. The Atmospheric Chemistry and Climate Model Intercomparison Project (ACCMIP): Overview and Description of Models, Simulations and Climate Diagnostics

    Science.gov (United States)

    Lamarque, J.-F.; Shindell, D. T.; Naik, V.; Plummer, D.; Josse, B.; Righi, M.; Rumbold, S. T.; Schulz, M.; Skeie, R. B.; Strode, S.; hide

    2013-01-01

    The Atmospheric Chemistry and Climate Model Intercomparison Project (ACCMIP) consists of a series of time slice experiments targeting the long-term changes in atmospheric composition between 1850 and 2100, with the goal of documenting composition changes and the associated radiative forcing. In this overview paper, we introduce the ACCMIP activity, the various simulations performed (with a requested set of 14) and the associated model output. The 16 ACCMIP models have a wide range of horizontal and vertical resolutions, vertical extent, chemistry schemes and interaction with radiation and clouds. While anthropogenic and biomass burning emissions were specified for all time slices in the ACCMIP protocol, it is found that the natural emissions are responsible for a significant range across models, mostly in the case of ozone precursors. The analysis of selected present-day climate diagnostics (precipitation, temperature, specific humidity and zonal wind) reveals biases consistent with state-of-the-art climate models. The model-to- model comparison of changes in temperature, specific humidity and zonal wind between 1850 and 2000 and between 2000 and 2100 indicates mostly consistent results. However, models that are clear outliers are different enough from the other models to significantly affect their simulation of atmospheric chemistry.

  12. Overview of the Meso-NH model version 5.4 and its applications

    Directory of Open Access Journals (Sweden)

    C. Lac

    2018-05-01

    Full Text Available This paper presents the Meso-NH model version 5.4. Meso-NH is an atmospheric non hydrostatic research model that is applied to a broad range of resolutions, from synoptic to turbulent scales, and is designed for studies of physics and chemistry. It is a limited-area model employing advanced numerical techniques, including monotonic advection schemes for scalar transport and fourth-order centered or odd-order WENO advection schemes for momentum. The model includes state-of-the-art physics parameterization schemes that are important to represent convective-scale phenomena and turbulent eddies, as well as flows at larger scales. In addition, Meso-NH has been expanded to provide capabilities for a range of Earth system prediction applications such as chemistry and aerosols, electricity and lightning, hydrology, wildland fires, volcanic eruptions, and cyclones with ocean coupling. Here, we present the main innovations to the dynamics and physics of the code since the pioneer paper of Lafore et al. (1998 and provide an overview of recent applications and couplings.

  13. Modeling of Chronic Myeloid Leukemia : An Overview of In Vivo Murine and Human Xenograft Models

    NARCIS (Netherlands)

    Sontakke, Pallavi; Jaques, Jenny; Vellenga, Edo; Schuringa, Jan Jacob

    2016-01-01

    Over the past years, a wide variety of in vivo mouse models have been generated in order to unravel the molecular pathology of Chronic Myeloid Leukemia (CML) and to develop and improve therapeutic approaches. These models range from (conditional) transgenic models, knock-in models, and murine bone

  14. Computing with Words in Decision support Systems: An overview on Models and Applications

    Directory of Open Access Journals (Sweden)

    Luis Martinez

    2010-10-01

    Full Text Available Decision making is inherent to mankind, as human beings daily face situations in which they should choose among different alternatives by means of reasoning and mental processes. Many of these decision problems are under uncertain environments with vague and imprecise information. This type of information is usually modelled by linguistic information because of the common use of language by the experts involved in the given decision situations, originating linguistic decision making. The use of linguistic information in decision making demands processes of Computing with Words to solve the related decision problems. Different methodologies and approaches have been proposed to accomplish such processes in an accurate and interpretable way. The good performance of linguistic computing dealing with uncertainty has caused a spread use of it in different types of decision based applications. This paper overviews the more significant and extended linguistic computing models due to its key role in linguistic decision making and a wide range of the most recent applications of linguistic decision support models.

  15. Overview of Building Information Modelling (BIM) adoption factors for construction organisations

    Science.gov (United States)

    Mohammad, W. N. S. Wan; Abdullah, M. R.; Ismail, S.; Takim, R.

    2018-04-01

    Improvement and innovation in building visualization, project coordination and communication are the major benefits generated by Building Information Modelling (BIM) for construction organisations. Thus, as many firms across the world would adopt BIM, however they do not know the clear direction in which path they are moving as there is no specific reference available for them to refer to. Hence, the paper seeks to identify the factors of BIM adoption from previous research. The methodology used in this paper is based on literature review from various sources such as conference articles and journals. Then, the findings were analysed using content analysis. The findings show that there are 24 factors found from literature that influence the adoption of BIM and four (4) factors such as vendor, organisational vision, knowledge, and implementation plan are among the least factors mentioned by previous researchers.

  16. Rainfall variability over southern Africa: an overview of current research using satellite and climate model data

    Science.gov (United States)

    Williams, C.; Kniveton, D.; Layberry, R.

    2009-04-01

    It is increasingly accepted that any possible climate change will not only have an influence on mean climate but may also significantly alter climatic variability. A change in the distribution and magnitude of extreme rainfall events (associated with changing variability), such as droughts or flooding, may have a far greater impact on human and natural systems than a changing mean. This issue is of particular importance for environmentally vulnerable regions such as southern Africa. The subcontinent is considered especially vulnerable to and ill-equipped (in terms of adaptation) for extreme events, due to a number of factors including extensive poverty, famine, disease and political instability. Rainfall variability is a function of scale, so high spatial and temporal resolution data are preferred to identify extreme events and accurately predict future variability. In this research, satellite-derived rainfall data are used as a basis for undertaking model experiments using a state-of-the-art climate model, run at both high and low spatial resolution. Once the model's ability to reproduce extremes has been assessed, idealised regions of sea surface temperature (SST) anomalies are used to force the model, with the overall aim of investigating the ways in which SST anomalies influence rainfall extremes over southern Africa. In this paper, a brief overview is given of the authors' research to date, pertaining to southern African rainfall. This covers (i) a description of present-day rainfall variability over southern Africa; (ii) a comparison of model simulated daily rainfall with the satellite-derived dataset; (iii) results from sensitivity testing of the model's domain size; and (iv) results from the idealised SST experiments.

  17. Functional evaluation of peripheral nerve regeneration and target reinnervation in animal models: a critical overview.

    Science.gov (United States)

    Navarro, Xavier

    2016-02-01

    Peripheral nerve injuries usually lead to severe loss of motor, sensory and autonomic functions in the patients. Due to the complex requirements for adequate axonal regeneration, functional recovery is often poorly achieved. Experimental models are useful to investigate the mechanisms related to axonal regeneration and tissue reinnervation, and to test new therapeutic strategies to improve functional recovery. Therefore, objective and reliable evaluation methods should be applied for the assessment of regeneration and function restitution after nerve injury in animal models. This review gives an overview of the most useful methods to assess nerve regeneration, target reinnervation and recovery of complex sensory and motor functions, their values and limitations. The selection of methods has to be adequate to the main objective of the research study, either enhancement of axonal regeneration, improving regeneration and reinnervation of target organs by different types of nerve fibres, or increasing recovery of complex sensory and motor functions. It is generally recommended to use more than one functional method for each purpose, and also to perform morphological studies of the injured nerve and the reinnervated targets. © 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  18. An Overview of Mechanical Properties and Material Modeling of Polylactide (PLA) for Medical Applications.

    Science.gov (United States)

    Bergström, Jörgen S; Hayman, Danika

    2016-02-01

    This article provides an overview of the connection between the microstructural state and the mechanical response of various bioresorbable polylactide (PLA) devices for medical applications. PLLA is currently the most commonly used material for bioresorbable stents and sutures, and its use is increasing in many other medical applications. The non-linear mechanical response of PLLA, due in part to its low glass transition temperature (T g ≈ 60 °C), is highly sensitive to the molecular weight and molecular orientation field, the degree of crystallinity, and the physical aging time. These microstructural parameters can be tailored for specific applications using different resin formulations and processing conditions. The stress-strain, deformation, and degradation response of a bioresorbable medical device is also strongly dependent on the time history of applied loads and boundary conditions. All of these factors can be incorporated into a suitable constitutive model that captures the multiple physics that are involved in the device response. Currently developed constitutive models already provide powerful computations simulation tools, and more progress in this area is expected to occur in the coming years.

  19. Modelling tourism demand in Madeira since 1946: and historical overview based on a time series approach

    Directory of Open Access Journals (Sweden)

    António Manuel Martins de Almeida

    2016-06-01

    Full Text Available Tourism is the leading economic sector in most islands and for that reason market trends are closely monitored due to the huge impacts of relatively minor changes in the demand patterns. An interesting line of research regarding the analysis of market trends concerns the examination of time series to get an historical overview of the data patterns. The modelling of demand patterns is obviously dependent on data availability, and the measurement of changes in demand patterns is quite often focused on a few decades. In this paper, we use long-term time-series data to analyse the evolution of the main markets in Madeira, by country of origin, in order to re-examine the Butler life cycle model, based on data available from 1946 onwards. This study is an opportunity to document the historical development of the industry in Madeira and to introduce the discussion about the rejuvenation of a mature destination. Tourism development in Madeira has experienced rapid growth until the late 90s, as one of the leading destinations in the European context. However, annual growth rates are not within acceptable ranges, which lead policy-makers and experts to recommend a thoughtfully assessment of the industry prospects.

  20. Kaiser Permanente/Sandia National health care model. Phase I prototype final report. Part 1 - model overview

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, D.; Yoshimura, A.; Butler, D.; Judson, R. [and others

    1996-11-01

    This report describes the results of a Cooperative Research and Development Agreement between Sandia National Laboratories and Kaiser Permanente Southern California to develop a prototype computer model of Kaiser Permanente`s health care delivery system. As a discrete event simulation, SimHCO models for each of 100,000 patients the progression of disease, individual resource usage, and patient choices in a competitive environment. SimHCO is implemented in the object-oriented programming language C++, stressing reusable knowledge and reusable software components. The versioned implementation of SimHCO showed that the object-oriented framework allows the program to grow in complexity in an incremental way. Furthermore, timing calculations showed that SimHCO runs in a reasonable time on typical workstations, and that a second phase model will scale proportionally and run within the system constraints of contemporary computer technology. This report is published as two documents: Model Overview and Domain Analysis. A separate Kaiser-proprietary report contains the Disease and Health Care Organization Selection Models.

  1. Overview of Modelling and Advanced Control Strategies for Wind Turbine Systems

    Directory of Open Access Journals (Sweden)

    Silvio Simani

    2015-11-01

    Full Text Available The motivation for this paper comes from a real need to have an overview of the challenges of modelling and control for very demanding systems, such as wind turbine systems, which require reliability, availability, maintainability, and safety over power conversion efficiency. These issues have begun to stimulate research and development in the wide control community particularly for these installations that need a high degree of “sustainability”. Note that this represents a key point for offshore wind turbines, since they are characterised by expensive and/or safety critical maintenance work. In this case, a clear conflict exists between ensuring a high degree of availability and reducing maintenance times, which affect the final energy cost. On the other hand, wind turbines have highly nonlinear dynamics, with a stochastic and uncontrollable driving force as input in the form of wind speed, thus representing an interesting challenge also from the modelling point of view. Suitable control methods can provide a sustainable optimisation of the energy conversion efficiency over wider than normally expected working conditions. Moreover, a proper mathematical description of the wind turbine system should be able to capture the complete behaviour of the process under monitoring, thus providing an important impact on the control design itself. In this way, the control scheme could guarantee prescribed performance, whilst also giving a degree of “tolerance” to possible deviation of characteristic properties or system parameters from standard conditions, if properly included in the wind turbine model itself. The most important developments in advanced controllers for wind turbines are also briefly referenced, and open problems in the areas of modelling of wind turbines are finally outlined.

  2. An Overview of Strategy Development Models and the Ward-Rivani Model

    OpenAIRE

    David Ward; Elena Rivani

    2005-01-01

    Numerous models for developing strategy, defining and aligning competitive advantage have been proposed over the years (and even centuries if we consider Arian, Sun Tzu etc.) including probably the most famous of all, the 5 forces model by Porter (P5F). With publications in the field of strategy now in the thousands it is difficult to get an overall picture of how to classify and appreciate strategy tools and models. Mintzberg et al. have developed schools of thought to help alleviate and cat...

  3. Swine as a model in renal physiology and nephrology: an overview

    International Nuclear Information System (INIS)

    Terris, J.M.

    1986-01-01

    Swine have become an important animal model in many areas of biomedical research for a variety of reasons. They are suited for studies in nephrology and renal physiology because they are the only mammal, with the exception of the dwarf water buffalo, which has been shown to have kidneys morphologically similar to the human. Maturational characteristics of fetal and neonatal kidney are similar to those of the newborn human infant. Therefore, studies to evaluate the pyeloureteral dynamics of human like multipapillary kidneys or developmental studies related to the newborn human cannot be conducted adequately in any other mammal. The following overview addresses the morphology and pelvic and ureteral dynamics of swine and human kidneys, maturation of renal hemodynamics in the neonate, renal function and the effects of anesthesia and diruetics on renal function in the pig. Additionally, the use of swine in other areas of interest to the nephrologist and renal physiologist are considered, eg, renal response to exercise, irradiation therapy, kidney preservation and renal transplantation

  4. Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and Dynamics.

    Science.gov (United States)

    Maximova, Tatiana; Moffatt, Ryan; Ma, Buyong; Nussinov, Ruth; Shehu, Amarda

    2016-04-01

    Investigation of macromolecular structure and dynamics is fundamental to understanding how macromolecules carry out their functions in the cell. Significant advances have been made toward this end in silico, with a growing number of computational methods proposed yearly to study and simulate various aspects of macromolecular structure and dynamics. This review aims to provide an overview of recent advances, focusing primarily on methods proposed for exploring the structure space of macromolecules in isolation and in assemblies for the purpose of characterizing equilibrium structure and dynamics. In addition to surveying recent applications that showcase current capabilities of computational methods, this review highlights state-of-the-art algorithmic techniques proposed to overcome challenges posed in silico by the disparate spatial and time scales accessed by dynamic macromolecules. This review is not meant to be exhaustive, as such an endeavor is impossible, but rather aims to balance breadth and depth of strategies for modeling macromolecular structure and dynamics for a broad audience of novices and experts.

  5. Modeling and simulation of a direct ethanol fuel cell: An overview

    Science.gov (United States)

    Abdullah, S.; Kamarudin, S. K.; Hasran, U. A.; Masdar, M. S.; Daud, W. R. W.

    2014-09-01

    The commercialization of Direct Ethanol Fuel Cells (DEFCs) is still hindered because of economic and technical reasons. Fundamental scientific research is required to more completely understanding the complex electrochemical behavior and engineering technology of DEFCs. To use the DEFC system in real-world applications, fast, reliable, and cost-effective methods are needed to explore this complex phenomenon and to predict the performance of different system designs. Thus, modeling and simulation play an important role in examining the DEFC system as well as in designing an optimized DEFC system. The current DEFC literature shows that modeling studies on DEFCs are still in their early stages and are not able to describe the DEFC system as a whole. Potential DEFC applications and their current status are also presented.

  6. Overview of the Graphical User Interface for the GERM Code (GCR Event-Based Risk Model

    Science.gov (United States)

    Kim, Myung-Hee; Cucinotta, Francis A.

    2010-01-01

    experiments, including the ability to model the beam line, the shielding of samples and sample holders, and the estimates of basic physical and biological outputs of the designed experiments. We present an overview of the GERM code GUI, as well as providing training applications.

  7. Overview of the Graphical User Interface for the GERMcode (GCR Event-Based Risk Model)

    Science.gov (United States)

    Kim, Myung-Hee Y.; Cucinotta, Francis A.

    2010-01-01

    experiments, including the ability to model the beam line, the shielding of samples and sample holders, and the estimates of basic physical and biological outputs of the designed experiments. We present an overview of the GERMcode GUI, as well as providing training applications.

  8. Additive Manufacturing Modeling and Simulation A Literature Review for Electron Beam Free Form Fabrication

    Science.gov (United States)

    Seufzer, William J.

    2014-01-01

    Additive manufacturing is coming into industrial use and has several desirable attributes. Control of the deposition remains a complex challenge, and so this literature review was initiated to capture current modeling efforts in the field of additive manufacturing. This paper summarizes about 10 years of modeling and simulation related to both welding and additive manufacturing. The goals were to learn who is doing what in modeling and simulation, to summarize various approaches taken to create models, and to identify research gaps. Later sections in the report summarize implications for closed-loop-control of the process, implications for local research efforts, and implications for local modeling efforts.

  9. Anxiety Psychopathology in African American Adults: Literature Review and Development of an Empirically Informed Sociocultural Model

    Science.gov (United States)

    Hunter, Lora Rose; Schmidt, Norman B.

    2010-01-01

    In this review, the extant literature concerning anxiety psychopathology in African American adults is summarized to develop a testable, explanatory framework with implications for future research. The model was designed to account for purported lower rates of anxiety disorders in African Americans compared to European Americans, along with other…

  10. Optimization and Simulation Modeling of Disaster Relief Supply Chain: A Literature Review

    OpenAIRE

    Feng, Keli; Bizimana, Emmanuel; Agu, Deedee D.; Issac, Tana T.

    2012-01-01

    Recent natural and man-made disasters underscore the need of a resilient and agile disaster relief supply chain to mitigate the damages and save people’s lives. Optimization and simulation modeling have become powerful and useful tools to help decision makers tackle problems related to disaster relief supply chain. This paper reviews optimization and simulation models used in the field of disaster relief supply chain. We review the literature of the facility location optimization problems of ...

  11. Overview of Millimeter Wave Communications for Fifth-Generation (5G) Wireless Networks—With a Focus on Propagation Models

    Science.gov (United States)

    Rappaport, Theodore S.; Xing, Yunchou; MacCartney, George R.; Molisch, Andreas F.; Mellios, Evangelos; Zhang, Jianhua

    2017-12-01

    This paper provides an overview of the features of fifth generation (5G) wireless communication systems now being developed for use in the millimeter wave (mmWave) frequency bands. Early results and key concepts of 5G networks are presented, and the channel modeling efforts of many international groups for both licensed and unlicensed applications are described here. Propagation parameters and channel models for understanding mmWave propagation, such as line-of-sight (LOS) probabilities, large-scale path loss, and building penetration loss, as modeled by various standardization bodies, are compared over the 0.5-100 GHz range.

  12. Cost management of IT beyond cost of ownership models : a state of the art overview of the Dutch financial services industry

    NARCIS (Netherlands)

    van Maanen, H.; Berghout, E.W.

    Controlling costs is an essential part of a value driven information technology (IT) management. This paper gives a state of the art overview of IT cost management practice. Both theoretical and an empirical approach are taken. The theoretical approach is based on both general accounting literature

  13. An overview of the recent approaches for terroir functional modelling, footprinting and zoning

    Science.gov (United States)

    Vaudour, E.; Costantini, E.; Jones, G. V.; Mocali, S.

    2014-11-01

    Notions of terroir and their conceptualization through agri-environmental sciences have become popular in many parts of world. Originally developed for wine, terroir now encompasses many other crops including fruits, vegetables, cheese, olive oil, coffee, cacao and other crops, linking the uniqueness and quality of both beverages and foods to the environment where they are produced, giving the consumer a sense of place. Climate, geology, geomorphology, and soil are the main environmental factors which compose the terroir effect at different scales. Often considered immutable at the cultural scale, the natural components of terroir are actually a set of processes, which together create a delicate equilibrium and regulation of its effect on products in both space and time. Due to both a greater need to better understand regional to site variations in crop production and the growth in spatial analytic technologies, the study of terroir has shifted from a largely descriptive regional science to a more applied, technical research field. Furthermore, the explosion of spatial data availability and sensing technologies has made the within-field scale of study more valuable to the individual grower. The result has been greater adoption but also issues associated with both the spatial and temporal scales required for practical applications, as well as the relevant approaches for data synthesis. Moreover, as soil microbial communities are known to be of vital importance for terrestrial processes by driving the major soil geochemical cycles and supporting healthy plant growth, an intensive investigation of the microbial organization and their function is also required. Our objective is to present an overview of existing data and modelling approaches for terroir functional modelling, footprinting and zoning at local and regional scales. This review will focus on three main areas of recent terroir research: (1) quantifying the influences of terroir components on plant growth

  14. A systematic literature review of open source software quality assessment models.

    Science.gov (United States)

    Adewumi, Adewole; Misra, Sanjay; Omoregbe, Nicholas; Crawford, Broderick; Soto, Ricardo

    2016-01-01

    Many open source software (OSS) quality assessment models are proposed and available in the literature. However, there is little or no adoption of these models in practice. In order to guide the formulation of newer models so they can be acceptable by practitioners, there is need for clear discrimination of the existing models based on their specific properties. Based on this, the aim of this study is to perform a systematic literature review to investigate the properties of the existing OSS quality assessment models by classifying them with respect to their quality characteristics, the methodology they use for assessment, and their domain of application so as to guide the formulation and development of newer models. Searches in IEEE Xplore, ACM, Science Direct, Springer and Google Search is performed so as to retrieve all relevant primary studies in this regard. Journal and conference papers between the year 2003 and 2015 were considered since the first known OSS quality model emerged in 2003. A total of 19 OSS quality assessment model papers were selected. To select these models we have developed assessment criteria to evaluate the quality of the existing studies. Quality assessment models are classified into five categories based on the quality characteristics they possess namely: single-attribute, rounded category, community-only attribute, non-community attribute as well as the non-quality in use models. Our study reflects that software selection based on hierarchical structures is found to be the most popular selection method in the existing OSS quality assessment models. Furthermore, we found that majority (47%) of the existing models do not specify any domain of application. In conclusion, our study will be a valuable contribution to the community and helps the quality assessment model developers in formulating newer models and also to the practitioners (software evaluators) in selecting suitable OSS in the midst of alternatives.

  15. An Overview of the U.S. Better Buildings Initiative as a Model for Other Countries

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xu [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). China Energy Group; Ge, Jing [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). China Energy Group; Feng, Wei [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). China Energy Group; Zhou, Nan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). China Energy Group

    2017-12-20

    This report offers a comprehensive overview of the U.S. Better Building Initiative, including the program structure, management and implementation. The report also summarizes lessons learned for a U.S. audience and offers approaches that might be replicated in China and elsewhere.

  16. A model for critical review of literature - with vaginismus as an example.

    Science.gov (United States)

    Wijma, Barbro; Engman, Maria; Wijma, Klaas

    2007-03-01

    In this article we present a behavioral model for the critical review of the literature within a certain research field, using vaginismus as an example. We searched the literature for the title word "vaginismus" and analyzed to what extent the articles dealt with the following seven categories: prevention, etiology, maintaining factors, consequences, object of intervention, method of intervention, and method of evaluation. In each category we scrutinized the content of the articles for biological, psychological, social, relational, and gender aspects. Quality requirements of etiological and treatment studies were then added and the results presented in a "quality-adjusted" model. There were 102 articles during 1985-2001, of which 22 were included in the review. Most of the articles deal with supposed predisposing factors of etiology and different aspects of intervention. Only a few articles discuss precipitating factors, maintaining factors, or consequences of the problem. No article had a gender analysis. Only 11 of the articles fulfilled some of the proposed quality criteria. We found the behavioral model with quality requirements useful for classifying and evaluating the literature of vaginismus. The model may also be used as a guide to design methodologically good studies.

  17. From EMPD to CFD – overview of different approaches for Heat Air and Moisture modeling in IEA Annex 41

    DEFF Research Database (Denmark)

    Janssens, Arnold; Woloszyn, Monica; Rode, Carsten

    2008-01-01

    of heat, air and moisture flows while including the important interactions that take place in buildings between the various building materials, components, and room air, and how those conditions are influenced by occupants and HVAC systems. Principles and some applications of different levels of modeling......This paper provides an overview of the recent developments of Heat, Air and Moisture modeling of Whole Buildings, which were carried out within a collaborative project of the International Energy Agency. The project has strived to advance the possibilities to calculate the integrated phenomena...

  18. From EMPD to CFD – overview of different approaches for Heat Air and Moisture modeling in IEA Annex 41

    DEFF Research Database (Denmark)

    Woloszyn, Monika; Rode, Carsten; Kalagasidis, Angela S.

    2009-01-01

    of heat, air and moisture flows while including the important interactions that take place in buildings between the various building materials, components, and room air, and how those conditions are influenced by occupants and HVAC systems. Principles and some applications of different levels of modeling......This paper provides an overview of the recent developments of Heat, Air and Moisture modeling of Whole Buildings, which were carried out within a collaborative project of the International Energy Agency. The project has strived to advance the possibilities to calculate the integrated phenomena...

  19. Best practice governance principles in the sports industry: an overview

    African Journals Online (AJOL)

    This overview examines the British and Australian models and codes of corporate governance since South African Company Law as well as Australian Company Law have their roots in British Company Law. From the literature seven pillars of good governance emerged and their applicability to sports governing bodies is ...

  20. The diverse application of laser hair removal therapy: a tertiary laser unit's experience with less common indications and a literature overview.

    Science.gov (United States)

    Koch, D; Pratsou, P; Szczecinska, W; Lanigan, S; Abdullah, A

    2015-01-01

    We describe the diversity of indications for laser hair removal (LHR) therapy and compare our experience with the literature. Patients' case notes referred to the Birmingham Regional Skin Laser Centre between 2003 and 2011 for laser hair removal, with indications other than hirsutism, were reviewed retrospectively. Thirty-one treated patients with the following indications were identified: hair-bearing skin grafts/flaps, intra-oral hair-bearing flap, Becker's naevus, localised nevoid hypertrichosis, peristomal hair-bearing skin, scrotal skin prior to vaginoplasty in male-to-female (MTF) gender reassignment, pilonidal sinus disease (PSD), pseudofolliculitis barbae (PFB) and hidradenitis suppurativa (HS). Seven patients with the following indications have been reported before: intra-oral hair-bearing graft, naevoid hypertrichosis and peristomal hair-bearing skin. A clinical review of the evidence available for each indication is provided. Our experience and that in the published literature suggest that LHR is a safe, well-tolerated and effective treatment modality for the indications we report, leading to significant symptom and functional improvement with high patient satisfaction. LHR appears effective in the treatment of chronic inflammatory conditions such as PSD, PFB and HS, particularly at an early disease stage. We aim to increase awareness of the diversity of laser hair removal indications and add evidence to the medical literature of the wide range of indications for this useful treatment modality.

  1. Work injury management model and implication in Hong Kong: a literature review.

    Science.gov (United States)

    Chong, Cecilia Suk-Mei; Cheng, Andy Shu-Kei

    2010-01-01

    The objective of this review is to explore the work injury management models in literatures and the essential components in different models. The resulting information could be used to develop an integrated holistic model that could be applied in the work injury management system in Hong Kong. A keyword search of MEDLINE and CINAHL databases was conducted. A total of 68 studies related to the management of an injury were found within the above mentioned electronic database. Together with the citation tracking, there were 13 studies left for selection after the exclusion screening. Only 7 out of those 13 studies met the inclusion criteria for review. It is noticeable that the most important component in the injury management model in the reviewed literatures is early intervention. Because of limitations in Employees' Compensation Ordinance in Hong Kong, there is an impetus to have a model and practice guideline for work injury management in Hong Kong to ensure the quality of injury management services. At the end of this paper, the authors propose a work injury management model based on the employees' compensation system in Hong Kong. This model can be used as a reference for those countries adopting similar legislation as in Hong Kong.

  2. Scaling up depot medroxyprogesterone acetate (DMPA): a systematic literature review illustrating the AIDED model.

    Science.gov (United States)

    Curry, Leslie; Taylor, Lauren; Pallas, Sarah Wood; Cherlin, Emily; Pérez-Escamilla, Rafael; Bradley, Elizabeth H

    2013-08-02

    Use of depot medroxyprogesterone acetate (DMPA), often known by the brand name Depo-Provera, has increased globally, particularly in multiple low- and middle-income countries (LMICs). As a reproductive health technology that has scaled up in diverse contexts, DMPA is an exemplar product innovation with which to illustrate the utility of the AIDED model for scaling up family health innovations. We conducted a systematic review of the enabling factors and barriers to scaling up DMPA use in LMICs. We searched 11 electronic databases for academic literature published through January 2013 (n = 284 articles), and grey literature from major health organizations. We applied exclusion criteria to identify relevant articles from peer-reviewed (n = 10) and grey literature (n = 9), extracting data on scale up of DMPA in 13 countries. We then mapped the resulting factors to the five AIDED model components: ASSESS, INNOVATE, DEVELOP, ENGAGE, and DEVOLVE. The final sample of sources included studies representing variation in geographies and methodologies. We identified 15 enabling factors and 10 barriers to dissemination, diffusion, scale up, and/or sustainability of DMPA use. The greatest number of factors were mapped to the ASSESS, DEVELOP, and ENGAGE components. Findings offer early empirical support for the AIDED model, and provide insights into scale up of DMPA that may be relevant for other family planning product innovations.

  3. The value of predicting restriction of fetal growth and compromise of its wellbeing: Systematic quantitative overviews (meta-analysis) of test accuracy literature.

    Science.gov (United States)

    Morris, Rachel K; Khan, Khalid S; Coomarasamy, Aravinthan; Robson, Stephen C; Kleijnen, Jos

    2007-03-08

    Restriction of fetal growth and compromise of fetal wellbeing remain significant causes of perinatal death and childhood disability. At present, there is a lack of scientific consensus about the best strategies for predicting these conditions before birth. Therefore, there is uncertainty about the best management of pregnant women who might have a growth restricted baby. This is likely to be due to a dearth of clear collated information from individual research studies drawn from different sources on this subject. A series of systematic reviews and meta-analyses will be undertaken to determine, among pregnant women, the accuracy of various tests to predict and/or diagnose fetal growth restriction and compromise of fetal wellbeing. We will search Medline, Embase, Cochrane Library, MEDION, citation lists of review articles and eligible primary articles and will contact experts in the field. Independent reviewers will select studies, extract data and assess study quality according to established criteria. Language restrictions will not be applied. Data synthesis will involve meta-analysis (where appropriate), exploration of heterogeneity and publication bias. The project will collate and synthesise the available evidence regarding the value of the tests for predicting restriction of fetal growth and compromise of fetal wellbeing. The systematic overviews will assess the quality of the available evidence, estimate the magnitude of potential benefits, identify those tests with good predictive value and help formulate practice recommendations.

  4. The value of predicting restriction of fetal growth and compromise of its wellbeing: Systematic quantitative overviews (meta-analysis of test accuracy literature

    Directory of Open Access Journals (Sweden)

    Robson Stephen C

    2007-03-01

    Full Text Available Abstract Background Restriction of fetal growth and compromise of fetal wellbeing remain significant causes of perinatal death and childhood disability. At present, there is a lack of scientific consensus about the best strategies for predicting these conditions before birth. Therefore, there is uncertainty about the best management of pregnant women who might have a growth restricted baby. This is likely to be due to a dearth of clear collated information from individual research studies drawn from different sources on this subject. Methods/Design A series of systematic reviews and meta-analyses will be undertaken to determine, among pregnant women, the accuracy of various tests to predict and/or diagnose fetal growth restriction and compromise of fetal wellbeing. We will search Medline, Embase, Cochrane Library, MEDION, citation lists of review articles and eligible primary articles and will contact experts in the field. Independent reviewers will select studies, extract data and assess study quality according to established criteria. Language restrictions will not be applied. Data synthesis will involve meta-analysis (where appropriate, exploration of heterogeneity and publication bias. Discussion The project will collate and synthesise the available evidence regarding the value of the tests for predicting restriction of fetal growth and compromise of fetal wellbeing. The systematic overviews will assess the quality of the available evidence, estimate the magnitude of potential benefits, identify those tests with good predictive value and help formulate practice recommendations.

  5. An Overview of the NASA Aviation Safety Program (AVSP) Systemwide Accident Prevention (SWAP) Human Performance Modeling (HPM) Element

    Science.gov (United States)

    Foyle, David C.; Goodman, Allen; Hooley, Becky L.

    2003-01-01

    An overview is provided of the Human Performance Modeling (HPM) element within the NASA Aviation Safety Program (AvSP). Two separate model development tracks for performance modeling of real-world aviation environments are described: the first focuses on the advancement of cognitive modeling tools for system design, while the second centers on a prescriptive engineering model of activity tracking for error detection and analysis. A progressive implementation strategy for both tracks is discussed in which increasingly more complex, safety-relevant applications are undertaken to extend the state-of-the-art, as well as to reveal potential human-system vulnerabilities in the aviation domain. Of particular interest is the ability to predict the precursors to error and to assess potential mitigation strategies associated with the operational use of future flight deck technologies.

  6. Toward a comprehensive, theoretical model of compassion fatigue: An integrative literature review.

    Science.gov (United States)

    Coetzee, Siedine K; Laschinger, Heather K S

    2018-03-01

    This study was an integrative literature review in relation to compassion fatigue models, appraising these models, and developing a comprehensive theoretical model of compassion fatigue. A systematic search on PubMed, EbscoHost (Academic Search Premier, E-Journals, Medline, PsycINFO, Health Source Nursing/Academic Edition, CINAHL, MasterFILE Premier and Health Source Consumer Edition), gray literature, and manual searches of included reference lists was conducted in 2016. The studies (n = 11) were analyzed, and the strengths and limitations of the compassion fatigue models identified. We further built on these models through the application of the conservation of resources theory and the social neuroscience of empathy. The compassion fatigue model shows that it is not empathy that puts nurses at risk of developing compassion fatigue, but rather a lack of resources, inadequate positive feedback, and the nurse's response to personal distress. By acting on these three aspects, the risk of developing compassion fatigue can be addressed, which could improve the retention of a compassionate and committed nurse workforce. © 2017 John Wiley & Sons Australia, Ltd.

  7. System Dynamics Modeling in Entrepreneurship Research: A Review of the Literature

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Zali

    2014-11-01

    Full Text Available System dynamics is a strategic approach for modeling complex systems and analyzing their behavior. Dynamic behavior in entrepreneurial system can be modeled using System Dynamics Approach and dynamic hypotheses about the system`s behavior can be proposed and tested using simulation and computer aided tools. However, as the review of literature shows, studies which link system dynamics modeling with entrepreneurship are rare and fragmented. This article presents a review of studies on the subject followed by integration and discussion on main research issues that have been the focus of previous studies. The main aim of this review is to categorize the available research related to the application of system dynamics modeling in entrepreneurship to integrate research and enable recommendations for future research. The Results reveal that the previous research could be categorized under a two dimensional taxonomy composed of level of analysis and level of modeling. The Level of analysis has three categories: micro level, meso level and macro level. The Level of modeling has six hierarchical levels. This study identifies several gaps in the literature and discusses the future directions in this field.

  8. A model for overview of student learning: a matrix of educational outcomes versus methodologies.

    Science.gov (United States)

    Johnsen, David C; Marshall, Teresa A; Finkelstein, Michael W; Cunningham-Ford, Marsha A; Straub-Morarend, Cheryl L; Holmes, David C; Armstrong, Steven R; Aquilino, Steven A; Sharp, Helen M; Solow, Catherine M; McQuistan, Michelle R

    2011-02-01

    A concise overview of an institution's aspirations for its students becomes increasingly elusive because dental education has evolving emphases on priorities like critical thinking and adapting to new technology. The purpose of this article is to offer a learner-oriented matrix that gives a focus for discussion and an overview of an institution's educational outcomes. On one axis of the matrix, common educational outcomes are listed: knowledge, technical skills, critical thinking, ethical and professional values, patient and practice management, and social responsibility awareness. On the other axis, methodologies are listed: definition, cultivation strategies, measures (summative/formative, objective/subjective), institutional coordination, and competency determination. By completing the matrix, an overview of the process by which students reach these outcomes emerges. Each institution would likely complete the matrix differently and, ideally, with active discussion. While the matrix can first be used to establish "Where are we now?" for an institution, it can also be a starting point for more extensive matrices and further discussion. Vertical and horizontal analyses of the matrix provide a unique lens for viewing the institution's learning environment.

  9. Software Quality Evaluation Models Applicable in Health Information and Communications Technologies. A Review of the Literature.

    Science.gov (United States)

    Villamor Ordozgoiti, Alberto; Delgado Hito, Pilar; Guix Comellas, Eva María; Fernandez Sanchez, Carlos Manuel; Garcia Hernandez, Milagros; Lluch Canut, Teresa

    2016-01-01

    Information and Communications Technologies in healthcare has increased the need to consider quality criteria through standardised processes. The aim of this study was to analyse the software quality evaluation models applicable to healthcare from the perspective of ICT-purchasers. Through a systematic literature review with the keywords software, product, quality, evaluation and health, we selected and analysed 20 original research papers published from 2005-2016 in health science and technology databases. The results showed four main topics: non-ISO models, software quality evaluation models based on ISO/IEC standards, studies analysing software quality evaluation models, and studies analysing ISO standards for software quality evaluation. The models provide cost-efficiency criteria for specific software, and improve use outcomes. The ISO/IEC25000 standard is shown as the most suitable for evaluating the quality of ICTs for healthcare use from the perspective of institutional acquisition.

  10. Factors Models of Scrum Adoption in the Software Development Process: A Systematic Literature Review

    Directory of Open Access Journals (Sweden)

    Marilyn Sihuay

    2018-05-01

    Full Text Available (Background The adoption of Agile Software Development (ASD, in particular Scrum, has grown significantly since its introduction in 2001. However, in Lima, many ASDs implementations have been not suitable (uncompleted or inconsistent, thus losing benefits obtainable by this approach and the critical success factors in this context are unknown. (Objective To analyze factors models used in the evaluation of the adoption of ASDs, as these factors models can contribute to explaining the success or failure of these adoptions. (Method In this study we used a systematic literature review. (Result Ten models have been identified; their similarities and differences are presented. (Conclusion Each model identified consider different factors, however some of them are shared by five of these models, such as team member attributes, engaging customer, customer collaboration, experience and work environment.

  11. Eating disorders among fashion models: a systematic review of the literature.

    Science.gov (United States)

    Zancu, Simona Alexandra; Enea, Violeta

    2017-09-01

    In the light of recent concerns regarding the eating disorders among fashion models and professional regulations of fashion model occupation, an examination of the scientific evidence on this issue is necessary. The article reviews findings on the prevalence of eating disorders and body image concerns among professional fashion models. A systematic literature search was conducted using ProQUEST, EBSCO, PsycINFO, SCOPUS, and Gale Canage electronic databases. A very low number of studies conducted on fashion models and eating disorders resulted between 1980 and 2015, with seven articles included in this review. Overall, results of these studies do not indicate a higher prevalence of eating disorders among fashion models compared to non-models. Fashion models have a positive body image and generally do not report more dysfunctional eating behaviors than controls. However, fashion models are on average slightly underweight with significantly lower BMI than controls, and give higher importance to appearance and thin body shape, and thus have a higher prevalence of partial-syndrome eating disorders than controls. Despite public concerns, research on eating disorders among professional fashion models is extremely scarce and results cannot be generalized to all models. The existing research fails to clarify the matter of eating disorders among fashion models and given the small number of studies, further research is needed.

  12. An Overview of ICT Integration in Nigerian Colleges of Education and the Implications on Social Studies Pre-Service Teacher Training Programme: A Review of the Literature

    Directory of Open Access Journals (Sweden)

    Sani Alhaji Garba

    2013-02-01

    Full Text Available The influence of digital technology in society has made ICT literacy a basic requirement needed by all to survive the challenge of living in the 21st. The education industry is now faced with the challenge of helping learners to acquire this literacy. Coping with this challenge requires breeding teachers’ with high level of proficiency in ICT literacy and competence. This study investigates the readiness of Nigerian Colleges of Education toward breeding social studies teachers with ICT literacy and competence. It is an exploratory conceptual study that is literature-based (document-based qualitative study approach. The study therefore explore literature to find out the benefit of ICT integration in social studies teacher education; the preparedness of Nigerian Colleges of Education for ICT integration; and the implications of the current state of technology integration on social studies objectives. Findings from this study indicated that, Colleges of education in Nigeria are not readily prepared for effective technology integration; much is still needed in terms of infrastructure and manpower development.

  13. Successful strategies in implementing a multidisciplinary team working in the care of patients with cancer: an overview and synthesis of the available literature.

    Science.gov (United States)

    Soukup, Tayana; Lamb, Benjamin W; Arora, Sonal; Darzi, Ara; Sevdalis, Nick; Green, James Sa

    2018-01-01

    In many health care systems globally, cancer care is driven by multidisciplinary cancer teams (MDTs). A large number of studies in the past few years and across different literature have been performed to better understand how these teams work and how they manage patient care. The aim of our literature review is to synthesize current scientific and clinical understanding on cancer MDTs and their organization; this, in turn, should provide an up-to-date summary of the current knowledge that those planning or leading cancer services can use as a guide for service implementation or improvement. We describe the characteristics of an effective MDT and factors that influence how these teams work. A range of factors pertaining to teamwork, availability of patient information, leadership, team and meeting management, and workload can affect how well MDTs are implemented within patient care. We also review how to assess and improve these teams. We present a range of instruments designed to be used with cancer MDTs - including observational tools, self-assessments, and checklists. We conclude with a practical outline of what appears to be the best practices to implement (Dos) and practices to avoid (Don'ts) when setting up MDT-driven cancer care.

  14. Successful strategies in implementing a multidisciplinary team working in the care of patients with cancer: an overview and synthesis of the available literature

    Science.gov (United States)

    Soukup, Tayana; Lamb, Benjamin W; Arora, Sonal; Darzi, Ara; Sevdalis, Nick; Green, James SA

    2018-01-01

    In many health care systems globally, cancer care is driven by multidisciplinary cancer teams (MDTs). A large number of studies in the past few years and across different literature have been performed to better understand how these teams work and how they manage patient care. The aim of our literature review is to synthesize current scientific and clinical understanding on cancer MDTs and their organization; this, in turn, should provide an up-to-date summary of the current knowledge that those planning or leading cancer services can use as a guide for service implementation or improvement. We describe the characteristics of an effective MDT and factors that influence how these teams work. A range of factors pertaining to teamwork, availability of patient information, leadership, team and meeting management, and workload can affect how well MDTs are implemented within patient care. We also review how to assess and improve these teams. We present a range of instruments designed to be used with cancer MDTs – including observational tools, self-assessments, and checklists. We conclude with a practical outline of what appears to be the best practices to implement (Dos) and practices to avoid (Don’ts) when setting up MDT-driven cancer care. PMID:29403284

  15. An overview on development and application of an experimental platform for quantitative cardiac imaging research in rabbit models of myocardial infarction.

    Science.gov (United States)

    Feng, Yuanbo; Bogaert, Jan; Oyen, Raymond; Ni, Yicheng

    2014-10-01

    To exploit the advantages of using rabbits for cardiac imaging research and to tackle the technical obstacles, efforts have been made under the framework of a doctoral research program. In this overview article, by cross-referencing the current literature, we summarize how we have developed a preclinical cardiac research platform based on modified models of reperfused myocardial infarction (MI) in rabbits; how the in vivo manifestations of cardiac imaging could be closely matched with those ex vivo macro- and microscopic findings; how these imaging outcomes could be quantitatively analyzed, validated and demonstrated; and how we could apply this cardiac imaging platform to provide possible solutions to certain lingering diagnostic and therapeutic problems in experimental cardiology. In particular, tissue components in acute cardiac ischemia have been stratified and characterized, post-infarct lipomatous metaplasia (LM) as a common but hardly illuminated clinical pathology has been identified in rabbit models, and a necrosis avid tracer as well as an anti-ischemic drug have been successfully assessed for their potential utilities in clinical cardiology. These outcomes may interest the researchers in the related fields and help strengthen translational research in cardiovascular diseases.

  16. Micro worlds versus boundary objects in group model building; evidence from the literature on problem definition and model conceptulization

    Energy Technology Data Exchange (ETDEWEB)

    Zagonel, Aldo A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Systems Engineering & Analysis; Andersen, David F. [University in Albany, NY (United States). The Rockefeller College of Public Affairs & Policy

    2007-03-01

    Based upon participant observation in group model building and content analysis of the system dynamics literature, we postulate that modeling efforts have a dual nature. On one hand, the modeling process aims to create a useful representation of a real-world system. This must be done, however, while aligning the clients’ mental models around a shared view of the system. There is significant overlap and confusion between these two goals and how they play out on a practical level. This research clarifies these distinctions by establishing an ideal-type dichotomy. To highlight the differences, we created two straw men: “micro world” characterizes a model that represents reality and “boundary object” represents a socially negotiated model. Using this framework, the literature was examined, revealing evidence for several competing views on problem definition and model conceptualization. The results are summarized in the text of this article, substantiated with strikingly polarized citations, often from the same authors. We also introduce hypotheses for the duality across the remaining phases of the modeling process. Finally, understanding and appreciation of the differences between these ideal types can promote constructive debate on their balance in system dynamics theory and practice.

  17. Conceptual Models in Health Informatics Research: A Literature Review and Suggestions for Development.

    Science.gov (United States)

    Gray, Kathleen; Sockolow, Paulina

    2016-02-24

    Contributing to health informatics research means using conceptual models that are integrative and explain the research in terms of the two broad domains of health science and information science. However, it can be hard for novice health informatics researchers to find exemplars and guidelines in working with integrative conceptual models. The aim of this paper is to support the use of integrative conceptual models in research on information and communication technologies in the health sector, and to encourage discussion of these conceptual models in scholarly forums. A two-part method was used to summarize and structure ideas about how to work effectively with conceptual models in health informatics research that included (1) a selective review and summary of the literature of conceptual models; and (2) the construction of a step-by-step approach to developing a conceptual model. The seven-step methodology for developing conceptual models in health informatics research explained in this paper involves (1) acknowledging the limitations of health science and information science conceptual models; (2) giving a rationale for one's choice of integrative conceptual model; (3) explicating a conceptual model verbally and graphically; (4) seeking feedback about the conceptual model from stakeholders in both the health science and information science domains; (5) aligning a conceptual model with an appropriate research plan; (6) adapting a conceptual model in response to new knowledge over time; and (7) disseminating conceptual models in scholarly and scientific forums. Making explicit the conceptual model that underpins a health informatics research project can contribute to increasing the number of well-formed and strongly grounded health informatics research projects. This explication has distinct benefits for researchers in training, research teams, and researchers and practitioners in information, health, and other disciplines.

  18. Futility Disputes: A Review of the Literature and Proposed Model for Dispute Navigation Through Trust Building.

    Science.gov (United States)

    Leland, Brian D; Torke, Alexia M; Wocial, Lucia D; Helft, Paul R

    2017-10-01

    Futility disputes in the intensive care unit setting have received significant attention in the literature over the past several years. Although the idea of improving communication in an attempt to resolve these challenging situations has been regularly discussed, the concept and role of trust building as the means by which communication improves and disputes are best navigated is largely absent. We take this opportunity to review the current literature on futility disputes and argue the important role of broken trust in these encounters, highlighting current evidence establishing the necessity and utility of trust in both medical decision-making and effective communication. Finally, we propose a futility dispute navigation model built upon improved communication through trust building.

  19. Neurocognitive Poetics: methods and models for investigating the neuronal and cognitive- affective bases of literature reception

    Directory of Open Access Journals (Sweden)

    Arthur M Jacobs

    2015-04-01

    Full Text Available A long tradition of research including classical rhetoric, aesthetics and poetics theory, formalism and structuralism, as well as current perspectives in (neurocognitive poetics has investigated structural and functional aspects of literature reception. Despite a wealth of literature published in specialised journals like Poetics, however, still little is known about how the brain processes and creates literary and poetic texts. Still, such stimulus material might be suited better than other genres for demonstrating the complexities with which our brain constructs the world in and around us, because it unifies thought and language, music and imagery in a clear, manageable way, most often with play, pleasure, and emotion (Schrott & Jacobs, 2011. In this paper, I discuss methods and models for investigating the neuronal and cognitive-affective bases of literary reading together with pertinent results from studies on poetics, text processing, emotion, or neuroaesthetics, and outline current challenges and future perspectives.

  20. A review of the literature related to modelling the interaction of copper and ultrasound

    International Nuclear Information System (INIS)

    Bowyer, W.H.; Crocker, R.L.

    1995-11-01

    The Swedish program for disposal of spent fuels will be faced with the problem of approving an ultrasonic testing scheme for large copper vessels to be used for the disposal. The microstructure of the vessels is uncertain. Manufacturing technology for such vessels is not yet established, but those under consideration could lead to a number of defects which may be critical to the performance of the canister. One method for detection of such defects is ultrasonic inspection. The reliability of this method is limited by the signal to noise ratio that may be achieved. The present literature review shows that there is excellent potential to make progress in the ultrasonic inspection by using one model as a theoretical predictor, the Rose model, and a further model model as an experimental validation, the ISMBB. Recommendations are made for the next stage of this project. 32 refs

  1. A Brief Literature Overview of Various Routes to Biorenewable Fuels from Lipids for the National Alliance for Advanced Biofuels and Bio-products (NAABB) Consortium

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, Karl O.; Hallen, Richard T.

    2011-03-29

    Renewable methods of producing transportation fuels are currently the focus of numerous large research efforts across the globe. Renewable fuel produced from algal lipids is one aspect of this research that could have profound implications on future transportation fuel requirements. However, technical challenges remain in several areas of algal-lipid-based fuels. These challenges include the identification and development of robust and productive algal species as well as extraction methods to recover the produced lipids. Not the least of these technical challenges is the conversion of the algae lipids to fungible fuels. This brief literature review focuses primarily on state-of-the-art “downstream” applications of producing fuel from fats and lipids, which can be applied to ongoing research with algae-derived lipids.

  2. Modeling the adaptation of infrastructures to prevent the effects of climate change : An overview of existing literature

    NARCIS (Netherlands)

    Chappin, E.J.L.; Van der Lei, T.

    2012-01-01

    Climate change is likely to affect our infrastructures and, consequently, the way society interacts with these infrastructures. For instance, higher average temperatures increase the need for electricity delivered through the grid in the summer due to augmented air-conditioning. As the scientific

  3. Successful strategies in implementing a multidisciplinary team working in the care of patients with cancer: an overview and synthesis of the available literature

    Directory of Open Access Journals (Sweden)

    Soukup T

    2018-01-01

    Full Text Available Tayana Soukup,1 Benjamin W Lamb,2 Sonal Arora,3 Ara Darzi,3 Nick Sevdalis,1 James SA Green4,5 1Health Service and Population Research Department, Centre for Implementation Science, King’s College London, London, UK; 2Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; 3Department of Surgery and Cancer, Center for Patient Safety and Service Quality, Imperial College London, 4Whipps Cross University Hospital, Barts Health NHS Trust, 5Faculty of Health and Social Care, London South Bank University, London, UK Abstract: In many health care systems globally, cancer care is driven by multidisciplinary cancer teams (MDTs. A large number of studies in the past few years and across different literature have been performed to better understand how these teams work and how they manage patient care. The aim of our literature review is to synthesize current scientific and clinical understanding on cancer MDTs and their organization; this, in turn, should provide an up-to-date summary of the current knowledge that those planning or leading cancer services can use as a guide for service implementation or improvement. We describe the characteristics of an effective MDT and factors that influence how these teams work. A range of factors pertaining to teamwork, availability of patient information, leadership, team and meeting management, and workload can affect how well MDTs are implemented within patient care. We also review how to assess and improve these teams. We present a range of instruments designed to be used with cancer MDTs – including observational tools, self-assessments, and checklists. We conclude with a practical outline of what appears to be the best practices to implement (Dos and practices to avoid (Don’ts when setting up MDT-driven cancer care. Keywords: cancer MDT, MDM, cancer meeting, patients with cancer

  4. Overview of fuel behaviour and core degradation, based on modelling analyses. Overview of fuel behaviour and core degradation, on the basis of modelling results

    International Nuclear Information System (INIS)

    Massara, Simone

    2013-01-01

    Since the very first hours after the accident at Fukushima-Daiichi, numerical simulations by means of severe accident codes have been carried out, aiming at highlighting the key physical phenomena allowing a correct understanding of the sequence of events, and - on a long enough timeline - improving models and methods, in order to reduce the discrepancy between calculated and measured data. A last long-term objective is to support the future decommissioning phase. The presentation summarises some of the available elements on the role of the fuel/cladding-water interaction, which became available only through modelling because of the absence of measured data directly related to the cladding-steam interaction. This presentation also aims at drawing some conclusions on the status of the modelling capabilities of current tools, particularly for the purpose of the foreseen application to ATF fuels: - analyses with MELCOR, MAAP, THALES2 and RELAP5 are presented; - input data are taken from BWR Mark-I Fukushima-Daiichi Units 1, 2 and 3, completed with operational data published by TEPCO. In the case of missing or incomplete data or hypotheses, these are adjusted to reduce the calculation/measurement discrepancy. The behaviour of the accident is well understood on a qualitative level (major trends on RPV pressure and water level, dry-wet and PCV pressure are well represented), allowing a certain level of confidence in the results of the analysis of the zirconium-steam reaction - which is accessible only through numerical simulations. These show an extremely fast sequence of events (here for Unit 1): - the top of fuel is uncovered in 3 hours (after the tsunami); - the steam line breaks at 6.5 hours. Vessel dries at 10 hours, with a heat-up rate in a first moment driven by the decay heat only (∼7 K/min) and afterwards by the chemical heat from Zr-oxidation (over 30 K/min), associated with massive hydrogen production. It appears that the level of uncertainty increases with

  5. Background report to the OECD Environmental Outlook to 2030. Overviews, details, and methodology of model-based analysis

    International Nuclear Information System (INIS)

    Bakkes, J.A.; Bagnoli, P.; Chateau, J.; Corfee-Morlot, J.; Kim, Y.G.

    2008-01-01

    This background report provides overviews and details of the model-based analyses for the Outlook. The global analyses have been conducted for 24 regions. They cover: climate change; urban air pollution and related health impacts; nutrient loading to the aquatic environment by agriculture and by trends in sanitation and sewerage; terrestrial biodiversity. A baseline scenario has been developed, as well as three policy packages. Most of the model-based analyses for the Environmental Outlook include a retrospect to 1970 and a look forward up to 2050. This enables an assessment of the cost of policy inaction and of the delaying of such action. This background report compares the impacts of the baseline for the various regions of the world. It also assesses the impact of uncertainties in the modelling for the key messages of the Environmental Outlook

  6. Tobacco counter-advertising: a review of the literature and a conceptual model for understanding effects.

    Science.gov (United States)

    Agostinelli, Gina; Grube, Joel W

    2003-01-01

    The tobacco counter-advertising literature is reviewed as it relates to basic process questions concerning what makes counter-advertisements effective. Limitations in addressing (a) counter-advertisement content and the psychological mediators targeted, (b) counter-advertisement style and the affective reactions targeted, (c) prior smoking experience, and (d) other audience factors are enumerated. A theoretical model based on alcohol advertising research is presented to address those limitations. The model addresses the practical research question of predicting when tobacco counter-advertising will work by examining the independent influence of each of these enumerated factors, as well as how these factors operate in concert, qualifying each other. The model also addresses the process question of explaining how counter-advertising works by identifying affective and cognitive processes as mediators. By understanding the processes that underlie the qualified findings, one can better advise the designers of tobacco counter-advertisements how to be more effective.

  7. Development of the Transitional Care Model for nursing care in Mainland China: A literature review

    Directory of Open Access Journals (Sweden)

    Zeng-Jie Ye

    2016-03-01

    Full Text Available Background: The Transitional Care Model (TCM for nursing care has yet to be implemented in China despite its success in Western countries. However, rapid social changes have demanded an upgrade in the quality of nursing care; in 2010, the Chinese government has acknowledged the need to implement the TCM in China. Objective: This study has the following objectives: (1 perform a thorough review of the literature regarding the development and implementation of the TCM in Mainland China within the past 5 years; (2 provide a comprehensive discussion of the current status, problems, and strategies related to the implementation of the TCM in Mainland China; and (3 suggest strategies pertaining to the future of the TCM in China. Design: The current pertinent literature is systematically reviewed. Data sources: Systematic and manual searches in computerized databases for relevant studies regarding the TCM led to the inclusion of 26 papers in this review. Review methods: Abstracts that satisfied the inclusion criteria were reviewed independently by the two authors of this manuscript, and discrepancies were resolved through discussion. The same reviewers independently assessed the paper in its entirety for selected abstracts. Results: The present English literature review revealed a paucity of updated information about the development and implementation of the TCM in Mainland China. Nevertheless, the dramatic growth of the TCM in the past 5 years has had a vital impact within the society and in nursing development. This review also revealed numerous issues regarding the focus of the TCM. Overall implications for practice and recommendations for future research are discussed. Conclusion: Despite the potential of this nursing model to have a successful and beneficial impact in Mainland China, it remains an under-researched topic. Further research on education and training as well as premium policies for nurses under the TCM are needed. Keywords: Transitional

  8. Understanding and Resolving Failures in Human-Robot Interaction: Literature Review and Model Development

    Directory of Open Access Journals (Sweden)

    Shanee Honig

    2018-06-01

    Full Text Available While substantial effort has been invested in making robots more reliable, experience demonstrates that robots operating in unstructured environments are often challenged by frequent failures. Despite this, robots have not yet reached a level of design that allows effective management of faulty or unexpected behavior by untrained users. To understand why this may be the case, an in-depth literature review was done to explore when people perceive and resolve robot failures, how robots communicate failure, how failures influence people's perceptions and feelings toward robots, and how these effects can be mitigated. Fifty-two studies were identified relating to communicating failures and their causes, the influence of failures on human-robot interaction (HRI, and mitigating failures. Since little research has been done on these topics within the HRI community, insights from the fields of human computer interaction (HCI, human factors engineering, cognitive engineering and experimental psychology are presented and discussed. Based on the literature, we developed a model of information processing for robotic failures (Robot Failure Human Information Processing, RF-HIP, that guides the discussion of our findings. The model describes the way people perceive, process, and act on failures in human robot interaction. The model includes three main parts: (1 communicating failures, (2 perception and comprehension of failures, and (3 solving failures. Each part contains several stages, all influenced by contextual considerations and mitigation strategies. Several gaps in the literature have become evident as a result of this evaluation. More focus has been given to technical failures than interaction failures. Few studies focused on human errors, on communicating failures, or the cognitive, psychological, and social determinants that impact the design of mitigation strategies. By providing the stages of human information processing, RF-HIP can be used as a

  9. An efficient method of exploring simulation models by assimilating literature and biological observational data.

    Science.gov (United States)

    Hasegawa, Takanori; Nagasaki, Masao; Yamaguchi, Rui; Imoto, Seiya; Miyano, Satoru

    2014-07-01

    Recently, several biological simulation models of, e.g., gene regulatory networks and metabolic pathways, have been constructed based on existing knowledge of biomolecular reactions, e.g., DNA-protein and protein-protein interactions. However, since these do not always contain all necessary molecules and reactions, their simulation results can be inconsistent with observational data. Therefore, improvements in such simulation models are urgently required. A previously reported method created multiple candidate simulation models by partially modifying existing models. However, this approach was computationally costly and could not handle a large number of candidates that are required to find models whose simulation results are highly consistent with the data. In order to overcome the problem, we focused on the fact that the qualitative dynamics of simulation models are highly similar if they share a certain amount of regulatory structures. This indicates that better fitting candidates tend to share the basic regulatory structure of the best fitting candidate, which can best predict the data among candidates. Thus, instead of evaluating all candidates, we propose an efficient explorative method that can selectively and sequentially evaluate candidates based on the similarity of their regulatory structures. Furthermore, in estimating the parameter values of a candidate, e.g., synthesis and degradation rates of mRNA, for the data, those of the previously evaluated candidates can be utilized. The method is applied here to the pharmacogenomic pathways for corticosteroids in rats, using time-series microarray expression data. In the performance test, we succeeded in obtaining more than 80% of consistent solutions within 15% of the computational time as compared to the comprehensive evaluation. Then, we applied this approach to 142 literature-recorded simulation models of corticosteroid-induced genes, and consequently selected 134 newly constructed better models. The

  10. Overview of Dioxin Kinetics and Application of Dioxin Physiologically Based Phannacokinetic (PBPK) Models to Risk Assessment

    Science.gov (United States)

    The available data on the pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in animals and humans have been thoroughly reviewed in literature. It is evident based on these reviews and other analyses that three distinctive features of TCDD play important roles in dete...

  11. Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008

    Directory of Open Access Journals (Sweden)

    Montazeri Ali

    2009-12-01

    Full Text Available Abstract Background Health-related quality of life and survival are two important outcome measures in cancer research and practice. The aim of this paper is to examine the relationship between quality of life data and survival time in cancer patients. Methods A review was undertaken of all the full publications in the English language biomedical journals between 1982 and 2008. The search was limited to cancer, and included the combination of keywords 'quality of life', 'patient reported-outcomes' 'prognostic', 'predictor', 'predictive' and 'survival' that appeared in the titles of the publications. In addition, each study was examined to ensure that it used multivariate analysis. Purely psychological studies were excluded. A manual search was also performed to include additional papers of potential interest. Results A total of 451 citations were identified in this rapid and systematic review of the literature. Of these, 104 citations on the relationship between quality of life and survival were found to be relevant and were further examined. The findings are summarized under different headings: heterogeneous samples of cancer patients, lung cancer, breast cancer, gastro-oesophageal cancers, colorectal cancer, head and neck cancer, melanoma and other cancers. With few exceptions, the findings showed that quality of life data or some aspects of quality of life measures were significant independent predictors of survival duration. Global quality of life, functioning domains and symptom scores - such as appetite loss, fatigue and pain - were the most important indicators, individually or in combination, for predicting survival times in cancer patients after adjusting for one or more demographic and known clinical prognostic factors. Conclusion This review provides evidence for a positive relationship between quality of life data or some quality of life measures and the survival duration of cancer patients. Pre-treatment (baseline quality of life

  12. Hanford Supplemental Treatment: Literature and Modeling Review of SRS HLW Salt Dissolution and Fractional Crystallization

    Energy Technology Data Exchange (ETDEWEB)

    Choi, A. S.; Flach, G. P.; Martino, C. J.; Zamecnik, J. R.; Harris, M. K.; Wilmarth, W. R.; Calloway, T. B.

    2005-03-23

    In order to accelerate waste treatment and disposal of Hanford tank waste by 2028, the Department of Energy (DOE) and CH2M Hill Hanford Group (CHG), Inc. are evaluating alternative technologies which will be used in conjunction with the Waste Treatment Plant (WTP) to safely pretreat and immobilize the tank waste. Several technologies (Bulk Vitrification and Steam Reforming) are currently being evaluated for immobilizing the pretreated waste. Since the WTP does not have sufficient capacity to pretreat all the waste going to supplemental treatment by the 2028 milestone, two technologies (Selective Dissolution and Fractional Crystallization) are being considered for pretreatment of salt waste. The scope of this task was to: (1) evaluate the recent Savannah River Site (SRS) Tank 41 dissolution campaign and other literature to provide a more complete understanding of selective dissolution, (2) provide an update on the progress of salt dissolution and modeling activities at SRS, (3) investigate SRS experience and outside literature sources on industrial equipment and experimental results of previous fractional crystallization processes, and (4) evaluate recent Hanford AP104 boildown experiments and modeling results and recommend enhancements to the Environmental Simulation Program (ESP) to improve its predictive capabilities. This report provides a summary of this work and suggested recommendations.

  13. Conditions and consequences of medical futility--from a literature review to a clinical model.

    Science.gov (United States)

    Löfmark, R; Nilstun, T

    2002-04-01

    To present an analysis of "futility" that is useful in the clinical setting. Literature review. According to Medline more than 750 articles have been published about medical futility. Three criteria (language, time period, and the authors expressed their own opinions) singled out 43 of them. The authors' opinions about futility were analysed using the scheme: "If certain conditions are satisfied, then a particular measure is futile" and "If a particular measure is futile, then certain moral consequences are implied". Regarding conditions, most authors stated that judgments about futility should be made by physicians. The measure was usually some kind of medical treatment, and the goals related to quality of life, physiological improvement, or prolongation of life. The probability of success in reaching the goal was in most cases described in semiquantitative terms. Regarding consequences, the authors stated that health care professionals may (sometimes ought or should) withhold or withdraw a futile measure, most often after a dialogue with the patient (29 articles), but sometimes without informing the patient (nine articles), or with one-way information (four articles). Over time more and more articles recommend that the patient should be involved in joint decision making. Based on this literature review a clinical model was developed. The model, requiring that conditions and consequences should be made explicit, may, in "futility situations", facilitate both the collection of the necessary information and make the moral implications visible. It also makes communication about measures considered to be futile possible without using such ambiguous terms as "futile".

  14. Models and Approaches for Integrating Protected Areas with Their Surroundings: A Review of the Literature

    Directory of Open Access Journals (Sweden)

    Wenwu Du

    2015-06-01

    Full Text Available Several studies have identified threats that originate in areas surrounding protected areas (PAs. While there have been various efforts to integrate PAs with their surroundings, considerable challenges remain. Here we summarize these efforts to date, discuss their effectiveness, and provide recommendations for future research. Based on a broad literature review of theoretical and applied approaches, we have outlined 68 models for balancing conservation and sustainable development in PAs. We comprehensively analyzed 23 of these models for integrating PAs with their surroundings. They were divided into two categories: area-oriented and process-oriented approaches. This review reveals the absolute necessity of combining these two approaches for future conservation and sustainable development of PAs.

  15. Literature Review of Enterprise Systems Research Using Institutional Theory: Towards a Conceptual Model

    DEFF Research Database (Denmark)

    Svejvig, Per

    This paper sets out to examine the use of institutional theory as a conceptually rich lens to study social issues of enterprise systems (ES) research. More precisely, the purpose is to categorize current ES research using institutional theory to develop a conceptual model that advances ES research...... model which advocates for multi-level and multi-theory approaches, and applies newer institutional aspects such as institutional logics. The findings show that institutional theory in ES research is in its infancy and adopts mainly traditional institutional aspects like isomorphism....... Key institutional features are presented such as isomorphism, rationalized myths, bridging macro and micro structures, and institutional logics and their implications for ES research are discussed. Through a literature review of 180 articles, of which 18 papers are selected, we build a conceptual...

  16. GeneTopics - interpretation of gene sets via literature-driven topic models

    Science.gov (United States)

    2013-01-01

    Background Annotation of a set of genes is often accomplished through comparison to a library of labelled gene sets such as biological processes or canonical pathways. However, this approach might fail if the employed libraries are not up to date with the latest research, don't capture relevant biological themes or are curated at a different level of granularity than is required to appropriately analyze the input gene set. At the same time, the vast biomedical literature offers an unstructured repository of the latest research findings that can be tapped to provide thematic sub-groupings for any input gene set. Methods Our proposed method relies on a gene-specific text corpus and extracts commonalities between documents in an unsupervised manner using a topic model approach. We automatically determine the number of topics summarizing the corpus and calculate a gene relevancy score for each topic allowing us to eliminate non-specific topics. As a result we obtain a set of literature topics in which each topic is associated with a subset of the input genes providing directly interpretable keywords and corresponding documents for literature research. Results We validate our method based on labelled gene sets from the KEGG metabolic pathway collection and the genetic association database (GAD) and show that the approach is able to detect topics consistent with the labelled annotation. Furthermore, we discuss the results on three different types of experimentally derived gene sets, (1) differentially expressed genes from a cardiac hypertrophy experiment in mice, (2) altered transcript abundance in human pancreatic beta cells, and (3) genes implicated by GWA studies to be associated with metabolite levels in a healthy population. In all three cases, we are able to replicate findings from the original papers in a quick and semi-automated manner. Conclusions Our approach provides a novel way of automatically generating meaningful annotations for gene sets that are directly

  17. An overview of modeling methods for thermal mixing and stratification in large enclosures for reactor safety analysis

    Energy Technology Data Exchange (ETDEWEB)

    Haihua Zhao; Per F. Peterson

    2010-10-01

    Thermal mixing and stratification phenomena play major roles in the safety of reactor systems with large enclosures, such as containment safety in current fleet of LWRs, long-term passive containment cooling in Gen III+ plants including AP-1000 and ESBWR, the cold and hot pool mixing in pool type sodium cooled fast reactor systems (SFR), and reactor cavity cooling system behavior in high temperature gas cooled reactors (HTGR), etc. Depending on the fidelity requirement and computational resources, 0-D steady state models (heat transfer correlations), 0-D lumped parameter based transient models, 1-D physical-based coarse grain models, and 3-D CFD models are available. Current major system analysis codes either have no models or only 0-D models for thermal stratification and mixing, which can only give highly approximate results for simple cases. While 3-D CFD methods can be used to analyze simple configurations, these methods require very fine grid resolution to resolve thin substructures such as jets and wall boundaries. Due to prohibitive computational expenses for long transients in very large volumes, 3-D CFD simulations remain impractical for system analyses. For mixing in stably stratified large enclosures, UC Berkeley developed 1-D models basing on Zuber’s hierarchical two-tiered scaling analysis (HTTSA) method where the ambient fluid volume is represented by 1-D transient partial differential equations and substructures such as free or wall jets are modeled with 1-D integral models. This allows very large reductions in computational effort compared to 3-D CFD modeling. This paper will present an overview on important thermal mixing and stratification phenomena in large enclosures for different reactors, major modeling methods and their advantages and limits, potential paths to improve simulation capability and reduce analysis uncertainty in this area for advanced reactor system analysis tools.

  18. Equation of state modelling of systems with ionic liquids: Literature review and application with the Cubic Plus Association (CPA) model

    DEFF Research Database (Denmark)

    Maia, Filipa Meireles; Tsivintzelis, Ioannis; Rodriguez, Oscar

    2012-01-01

    For the last decade ionic liquids have been regarded as compounds of interest by the academic and industrial communities. These compounds present several advantages when compared to other typical solvents. However, because of their novelty, a deep understanding of their phase behaviour and their ......For the last decade ionic liquids have been regarded as compounds of interest by the academic and industrial communities. These compounds present several advantages when compared to other typical solvents. However, because of their novelty, a deep understanding of their phase behaviour...... and their interactions with other components is still needed. In this work, we made a review of literature studies on modelling systems with ionic liquids using equation of state models. Furthermore, we applied the Cubic Plus Association (CPA) equation of state to describe the phase behaviour of two ionic liquids, 1...... is in progress for improving the modelling of LLE with the CPA equation of state....

  19. Quality Assurance in Higher Education: A Review of Literature

    Science.gov (United States)

    Ryan, Tricia

    2015-01-01

    This paper examines the literature surrounding quality assurance in global higher education. It provides an overview of accreditation as a mechanism to ensure quality in higher education, examines models of QA, and explores the concept of quality (including definitions of quality and quality assurance). In addition, this paper provides a review of…

  20. Program overview

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    The program overview describes the following resources and facilities; laser facilities, main laser room, target room, energy storage, laboratory area, building support systems, general plant project, and the new trailer complex

  1. Disability Overview

    Science.gov (United States)

    ... About CDC.gov . Disability & Health Home Disability Overview Disability Inclusion Barriers to Inclusion Inclusion Strategies Inclusion in Programs & Activities Resources Healthy Living Disability & Physical Activity Disability & Obesity Disability & Smoking Disability & Breast ...

  2. Vulvovaginitis - overview

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000897.htm Vulvovaginitis - overview To use the sharing features on this page, please enable JavaScript. Vulvovaginitis or vaginitis is swelling or infection of the ...

  3. Identifying overrepresented concepts in gene lists from literature: a statistical approach based on Poisson mixture model

    Directory of Open Access Journals (Sweden)

    Zhai Chengxiang

    2010-05-01

    Full Text Available Abstract Background Large-scale genomic studies often identify large gene lists, for example, the genes sharing the same expression patterns. The interpretation of these gene lists is generally achieved by extracting concepts overrepresented in the gene lists. This analysis often depends on manual annotation of genes based on controlled vocabularies, in particular, Gene Ontology (GO. However, the annotation of genes is a labor-intensive process; and the vocabularies are generally incomplete, leaving some important biological domains inadequately covered. Results We propose a statistical method that uses the primary literature, i.e. free-text, as the source to perform overrepresentation analysis. The method is based on a statistical framework of mixture model and addresses the methodological flaws in several existing programs. We implemented this method within a literature mining system, BeeSpace, taking advantage of its analysis environment and added features that facilitate the interactive analysis of gene sets. Through experimentation with several datasets, we showed that our program can effectively summarize the important conceptual themes of large gene sets, even when traditional GO-based analysis does not yield informative results. Conclusions We conclude that the current work will provide biologists with a tool that effectively complements the existing ones for overrepresentation analysis from genomic experiments. Our program, Genelist Analyzer, is freely available at: http://workerbee.igb.uiuc.edu:8080/BeeSpace/Search.jsp

  4. An overview of measuring and modelling dose and risk from ionising radiation for medical exposures

    International Nuclear Information System (INIS)

    Tootell, Andrew; Szczepura, Katy; Hogg, Peter

    2014-01-01

    Purpose: This paper gives an overview of the methods that are used to calculate dose and risk from exposure to ionizing radiation as a support to other papers in this special issue. Background: The optimization of radiation dose is a legal requirement in medical exposures. This review paper aims to provide the reader with knowledge of dose by providing definitions and concepts of absorbed, effective and equivalent dose. Criticisms of the use of effective dose to infer the risk of an exposure to an individual will be discussed and an alternative approach considering the lifetime risks of cancer incidence will be considered. Prior to any dose or risk calculation, data concerning the dose absorbed by the patient needs to be collected. This paper will describe and discuss the main concepts and methods that can be utilised by a researcher in dose assessments. Concepts behind figures generated by imaging equipment such as dose-area-product, computed tomography dose index, dose length product and their use in effective dose calculations will be discussed. Processes, advantages and disadvantages in the simulation of exposures using the Monte Carlo method and direct measurement using digital dosimeters or thermoluminescent dosimeters will be considered. Beyond this special issue, it is proposed that this paper could serve as a teaching or CPD tool for personnel working or studying medical imaging

  5. Model of urban water management towards water sensitive city: a literature review

    Science.gov (United States)

    Maftuhah, D. I.; Anityasari, M.; Sholihah, M.

    2018-04-01

    Nowadays, many cities are facing with complex issues such as climate change, social, economic, culture, and environmental problems, especially urban water. In other words, the city has to struggle with the challenge to make sure its sustainability in all aspects. This research focuses on how to ensure the city sustainability and resilience on urban water management. Many research were not only conducted in urban water management, but also in sustainability itself. Moreover, water sustainability shifts from urban water management into water sensitive city. This transition needs comprehensive aspects such as social, institutional dynamics, technical innovation, and local contents. Some literatures about model of urban water management and the transition towards water sensitivity had been reviewed in this study. This study proposed discussion about model of urban water management and the transition towards water sensitive city. Research findings suggest that there are many different models developed in urban water management, but they are not comprehensive yet and only few studies discuss about the transition towards water sensitive and resilience city. The drawbacks of previous research can identify and fulfill the gap of this study. Therefore, the paper contributes a general framework for the urban water management modelling studies.

  6. In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

    Science.gov (United States)

    Helms, Hans C; Abbott, N Joan; Burek, Malgorzata; Cecchelli, Romeo; Couraud, Pierre-Olivier; Deli, Maria A; Förster, Carola; Galla, Hans J; Romero, Ignacio A; Shusta, Eric V; Stebbins, Matthew J; Vandenhaute, Elodie; Weksler, Babette

    2016-01-01

    The endothelial cells lining the brain capillaries separate the blood from the brain parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial interface for exchange of nutrients, gases, and metabolites between blood and brain, and as a barrier for neurotoxic components of plasma and xenobiotics. This “blood-brain barrier” function is a major hindrance for drug uptake into the brain parenchyma. Cell culture models, based on either primary cells or immortalized brain endothelial cell lines, have been developed, in order to facilitate in vitro studies of drug transport to the brain and studies of endothelial cell biology and pathophysiology. In this review, we aim to give an overview of established in vitro blood–brain barrier models with a focus on their validation regarding a set of well-established blood–brain barrier characteristics. As an ideal cell culture model of the blood–brain barrier is yet to be developed, we also aim to give an overview of the advantages and drawbacks of the different models described. PMID:26868179

  7. CFD modelling and analysis of pulverized coal injection in blast furnace: an overview

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Yansong; Yu, Aibing [Laboratory for Simulation and Modelling of Particulate Systems, School of Materials Science and Engineering, The University of New South Wales (UNSW), Sydney, NSW 2052 (Australia); Zulli, Paul [BlueScope Steel Research (BSR), P.O. Box 202, Port Kembla, NSW 2505 (Australia)

    2011-05-15

    In order to understand the complicated phenomena of pulverized coal injection (PCI) process in blast furnace (BF), several mathematical models have been developed by the UNSW and BSR cooperation. These models are featuring from coal combustion in a pilot-scale test rig, to coal combustion in a real BF, and then to coal/coke combustion in a real BF, respectively. This paper reviews these PCI models in aspects of model developments and model applicability. The model development is firstly discussed in terms of model formulation, their new features and geometry/regions considered. The model applicability is then discussed in terms of main findings followed by the model evaluation on their advantages and limitations. It is indicated that the three PCI models are all able to describe PCI operation qualitatively. The model of coal/coke combustion in a real BF is more reliable for simulating in-furnace phenomena of PCI operation qualitatively and quantitatively. Such model gives a more reliable burnout prediction over the raceway surface, which could better represent the amount of unburnt char entering the coke bed. These models are useful for understanding the flow-thermo-chemical behaviours and then optimising the PCI operation in practice. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  8. Source modelling of train noise - Literature review and some initial measurements

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Xuetao; Jonasson, Hans; Holmberg, Kjell

    2000-07-01

    A literature review of source modelling of railway noise is reported. Measurements on a special test rig at Surahammar and on the new railway line between Arlanda and Stockholm City are reported and analyzed. In the analysis the train is modelled as a number of point sources with or without directivity and each source is combined with analytical sound propagation theory to predict the sound propagation pattern best fitting the measured data. Wheel/rail rolling noise is considered to be the most important noise source. The rolling noise can be modelled as an array of moving point sources, which have a dipole-like horizontal directivity and some kind of vertical directivity. In general it is necessary to distribute the point sources on several heights. Based on our model analysis the source heights for the rolling noise should be below the wheel axles and the most important height is about a quarter of wheel diameter above the railheads. When train speeds are greater than 250 km/h aerodynamic noise will become important and even dominant. It may be important for low frequency components only if the train speed is less than 220 km/h. Little data are available for these cases. It is believed that aerodynamic noise has dipole-like directivity. Its spectrum depends on many factors: speed, railway system, type of train, bogies, wheels, pantograph, presence of barriers and even weather conditions. Other sources such as fans, engine, transmission and carriage bodies are at most second order noise sources, but for trains with a diesel locomotive engine the engine noise will be dominant if train speeds are less than about 100 km/h. The Nord 2000 comprehensive model for sound propagation outdoors, together with the source model that is based on the understandings above, can suitably handle the problems of railway noise propagation in one-third octave bands although there are still problems left to be solved.

  9. Quicklook overview of model changes in Melcor 2.2: Rev 6342 to Rev 9496

    Energy Technology Data Exchange (ETDEWEB)

    Humphries, Larry L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    MELCOR 2.2 is a significant official release of the MELCOR code with many new models and model improvements. This report provides the code user with a quick review and characterization of new models added, changes to existing models, the effect of code changes during this code development cycle (rev 6342 to rev 9496), a preview of validation results with this code version. More detailed information is found in the code Subversion logs as well as the User Guide and Reference Manuals.

  10. Creating historical range of variation (HRV) time series using landscape modeling: Overview and issues [Chapter 8

    Science.gov (United States)

    Robert E. Keane

    2012-01-01

    Simulation modeling can be a powerful tool for generating information about historical range of variation (HRV) in landscape conditions. In this chapter, I will discuss several aspects of the use of simulation modeling to generate landscape HRV data, including (1) the advantages and disadvantages of using simulation, (2) a brief review of possible landscape models. and...

  11. An Overview of the Object Protocol Model (OPM) and the OPM Data Management Tools.

    Science.gov (United States)

    Chen, I-Min A.; Markowitz, Victor M.

    1995-01-01

    Discussion of database management tools for scientific information focuses on the Object Protocol Model (OPM) and data management tools based on OPM. Topics include the need for new constructs for modeling scientific experiments, modeling object structures and experiments in OPM, queries and updates, and developing scientific database applications…

  12. Growth and yield models in Spain: Historical overview, Contemporary Examples and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Bravo, F.; Alvarez-Gonzalez, J. G.; Rio, M. del; Barrio, M.; Bonet, J. a.; Bravo-Oviedo, A.; Calama, R.; Castedo-Dorado, F.; Crecente-Campo, F.; Condes, S.; Dieguez-Aranda, U.; Gonzalez-Martinez, S. C.; Lizarralde, I.; Nanos, N.; Madrigal, A.; Martinez-Millan, F. J.; Montero, G.; Ordonez, C.; Palahi, M.; Pique, M.; Rodriguez, F.; Rodriguez-Soalleiro, R.; Rojo, A.; Ruiz-Peinado, R.; Sanchez-Gonzalez, M.; Trasobares, A.; Vazquez-Pique, J.

    2011-07-01

    In this paper we present a review of forest models developed in Spain in recent years for both timber and non timber production and forest dynamics (regeneration, mortality,..). Models developed are whole stand, size (diameter) class and individual-tree. The models developed to date have been developed using data from permanent plots, experimental sites and the National Forest Inventory. In this paper we show the different sub-models developed so far and the friendly use software. Main perspectives of forest modelling in Spain are presented. (Author) 107 refs.

  13. An overview of mice models: a key for understanding subtypes of mania

    Directory of Open Access Journals (Sweden)

    Jorge Mauricio Cuartas Arias

    2016-09-01

    Full Text Available Animal models have been broadly used in the study of pathophysiology and molecular and neurochemical pathways in neuropsychiatric diseases. Different approaches have used both consanguineous and non-consanguineous mice models to model behavioral patterns associated with the maniac spectrum. However, the disadvantages of validating clinical and experimental protocols have hindered the replication of these studies. In this article, the advantages and disadvantages of using consanguineous lines and non-consanguineous stocks in mice animal models for the study of mania and its subtypes are discussed. Additionally, new experimental alternatives to advance the pathogenesis and pharmacogenetics of mania using animal models are proposed and analyzed.

  14. Corrosion and deuterium ingress in CANDU pressure tubes: a literature review and new model

    International Nuclear Information System (INIS)

    Frankel, G.S.; Markworth, A.J.; Sehgal, A.

    1997-02-01

    This report addresses the problem of Zr corrosion and D uptake in two ways. The published literature and some proprietary reports are reviewed and critically assessed in the first section. A new model for Zr corrosion is then presented in the second section. The rate of corrosion is shown to be dependent on the rate of transformation of the protective inner oxide layer to a porous outer layer. The mechanism of this transformation is not known, and should be the subject of future investigations. It is assumed in the model that zirconia chemically dissolves into the solution at the pore bottom. The rate of this dissolution reaction depends on the local pH, which will increase if there is a build-up of deuteroxyl ions generated in the cathodic part of the Zr corrosion reaction. A mathematical description of this model containing several parameters with unknown values is presented. Assuming certain values of these parameters results in predictions of oxide formation (and thus D build-up) that are similar to observations. (author). 25 refs., 15 figs

  15. Literature Review and Assessment of Plant and Animal Transfer Factors Used in Performance Assessment Modeling

    International Nuclear Information System (INIS)

    Robertson, David E.; Cataldo, Dominic A.; Napier, Bruce A.; Krupka, Kenneth M.; Sasser, Lyle B.

    2003-01-01

    A literature review and assessment was conducted by Pacific Northwest National Laboratory (PNNL) to update information on plant and animal radionuclide transfer factors used in performance-assessment modeling. A group of 15 radionuclides was included in this review and assessment. The review is composed of four main sections, not including the Introduction. Section 2.0 provides a review of the critically important issue of physicochemical speciation and geochemistry of the radionuclides in natural soil-water systems as it relates to the bioavailability of the radionuclides. Section 3.0 provides an updated review of the parameters of importance in the uptake of radionuclides by plants, including root uptake via the soil-groundwater system and foliar uptake due to overhead irrigation. Section 3.0 also provides a compilation of concentration ratios (CRs) for soil-to-plant uptake for the 15 selected radionuclides. Section 4.0 provides an updated review on radionuclide uptake data for animal products related to absorption, homeostatic control, approach to equilibration, chemical and physical form, diet, and age. Compiled transfer coefficients are provided for cow's milk, sheep's milk, goat's milk, beef, goat meat, pork, poultry, and eggs. Section 5.0 discusses the use of transfer coefficients in soil, plant, and animal modeling using regulatory models for evaluating radioactive waste disposal or decommissioned sites. Each section makes specific suggestions for future research in its area.

  16. A literature review on business process modelling: new frontiers of reusability

    Science.gov (United States)

    Aldin, Laden; de Cesare, Sergio

    2011-08-01

    Business process modelling (BPM) has become fundamental for modern enterprises due to the increasing rate of organisational change. As a consequence, business processes need to be continuously (re-)designed as well as subsequently aligned with the corresponding enterprise information systems. One major problem associated with the design of business processes is reusability. Reuse of business process models has the potential of increasing the efficiency and effectiveness of BPM. This article critically surveys the existing literature on the problem of BPM reusability and more specifically on that State-of-the-Art research that can provide or suggest the 'elements' required for the development of a methodology aimed at discovering reusable conceptual artefacts in the form of patterns. The article initially clarifies the definitions of business process and business process model; then, it sets out to explore the previous research conducted in areas that have an impact on reusability in BPM. The article concludes by distilling directions for future research towards the development of apatterns-based approach to BPM; an approach that brings together the contributions made by the research community in the areas of process mining and discovery, declarative approaches and ontologies.

  17. Literature Review and Assessment of Plant and Animal Transfer Factors Used in Performance Assessment Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, David E.; Cataldo, Dominic A.; Napier, Bruce A.; Krupka, Kenneth M.; Sasser, Lyle B.

    2003-07-20

    A literature review and assessment was conducted by Pacific Northwest National Laboratory (PNNL) to update information on plant and animal radionuclide transfer factors used in performance-assessment modeling. A group of 15 radionuclides was included in this review and assessment. The review is composed of four main sections, not including the Introduction. Section 2.0 provides a review of the critically important issue of physicochemical speciation and geochemistry of the radionuclides in natural soil-water systems as it relates to the bioavailability of the radionuclides. Section 3.0 provides an updated review of the parameters of importance in the uptake of radionuclides by plants, including root uptake via the soil-groundwater system and foliar uptake due to overhead irrigation. Section 3.0 also provides a compilation of concentration ratios (CRs) for soil-to-plant uptake for the 15 selected radionuclides. Section 4.0 provides an updated review on radionuclide uptake data for animal products related to absorption, homeostatic control, approach to equilibration, chemical and physical form, diet, and age. Compiled transfer coefficients are provided for cow’s milk, sheep’s milk, goat’s milk, beef, goat meat, pork, poultry, and eggs. Section 5.0 discusses the use of transfer coefficients in soil, plant, and animal modeling using regulatory models for evaluating radioactive waste disposal or decommissioned sites. Each section makes specific suggestions for future research in its area.

  18. Overview of MELCOR 1.8.4: Modeling advances and assessment

    International Nuclear Information System (INIS)

    Gauntt, R.O.; Cole, R.K.; Rodriguez, S.B.; Young, M.F.; Gasser, R.D.

    1998-01-01

    The newly released MELCOR 1.8.4 reactor accident analysis code contains many new modeling features as well as improvements to existing models. New model additions to the MELCOR code include a model for predicting enhanced depletion rates for hygroscopic aerosols and a model for predicting the chemisorption of Cesium to the surfaces of piping. Improvements to existing models include: upgrading the core module (COR) to handle flow redistribution resulting from the formation of core blockages, improving the thermal hydraulics (CVH) coupling with COR to handle flow reversal situations, and upgrading the fission product scrubbing model to incorporate the SPARC90 code. Significant upgrading of the COR package core degradation modeling was also included in the new code release version. New and improved models are described in the following paper. In addition, a number of assessment analyses were recently performed, focusing on demonstrating the new and improved capabilities in the code. Results of assessment calculations demonstrating code performance for aerosol (pool) scrubbing, hygroscopic aerosol behavior, and core degradation and hydrogen production are presented. Finally, ongoing code developments activities beyond MELCOR 1.8.4 are described. These include models for treating iodine behavior in containment sumps, pools, and atmosphere, and plans for implementing reflood models and the attendant effects on accident progression. Further improvements and additions to the core degradation modeling in MELCOR are described, including the implementation of enhanced clad failure models to treat clad ballooning and eutectic interaction with grid spacers, and expansion of the COR package to allow for improved representation of UO 2 -Zr eutectic behavior, improved melt relocation treatment, greater detail in describing aspects of BWR core degradation (fuel channel, bypass, and lower plenum), and more flexibility in modeling other structures in the core such as core plate

  19. Ecological validity of cost-effectiveness models of universal HPV vaccination: A systematic literature review.

    Science.gov (United States)

    Favato, Giampiero; Easton, Tania; Vecchiato, Riccardo; Noikokyris, Emmanouil

    2017-05-09

    The protective (herd) effect of the selective vaccination of pubertal girls against human papillomavirus (HPV) implies a high probability that one of the two partners involved in intercourse is immunised, hence preventing the other from this sexually transmitted infection. The dynamic transmission models used to inform immunisation policy should include consideration of sexual behaviours and population mixing in order to demonstrate an ecological validity, whereby the scenarios modelled remain faithful to the real-life social and cultural context. The primary aim of this review is to test the ecological validity of the universal HPV vaccination cost-effectiveness modelling available in the published literature. The research protocol related to this systematic review has been registered in the International Prospective Register of Systematic Reviews (PROSPERO: CRD42016034145). Eight published economic evaluations were reviewed. None of the studies showed due consideration of the complexities of human sexual behaviour and the impact this may have on the transmission of HPV. Our findings indicate that all the included models might be affected by a different degree of ecological bias, which implies an inability to reflect the natural demographic and behavioural trends in their outcomes and, consequently, to accurately inform public healthcare policy. In particular, ecological bias have the effect to over-estimate the preference-based outcomes of selective immunisation. A relatively small (15-20%) over-estimation of quality-adjusted life years (QALYs) gained with selective immunisation programmes could induce a significant error in the estimate of cost-effectiveness of universal immunisation, by inflating its incremental cost effectiveness ratio (ICER) beyond the acceptability threshold. The results modelled here demonstrate the limitations of the cost-effectiveness studies for HPV vaccination, and highlight the concern that public healthcare policy might have been

  20. Modeling language and cognition with deep unsupervised learning: a tutorial overview.

    Science.gov (United States)

    Zorzi, Marco; Testolin, Alberto; Stoianov, Ivilin P

    2013-01-01

    Deep unsupervised learning in stochastic recurrent neural networks with many layers of hidden units is a recent breakthrough in neural computation research. These networks build a hierarchy of progressively more complex distributed representations of the sensory data by fitting a hierarchical generative model. In this article we discuss the theoretical foundations of this approach and we review key issues related to training, testing and analysis of deep networks for modeling language and cognitive processing. The classic letter and word perception problem of McClelland and Rumelhart (1981) is used as a tutorial example to illustrate how structured and abstract representations may emerge from deep generative learning. We argue that the focus on deep architectures and generative (rather than discriminative) learning represents a crucial step forward for the connectionist modeling enterprise, because it offers a more plausible model of cortical learning as well as a way to bridge the gap between emergentist connectionist models and structured Bayesian models of cognition.

  1. Modeling Language and Cognition with Deep Unsupervised Learning:A Tutorial Overview

    Directory of Open Access Journals (Sweden)

    Marco eZorzi

    2013-08-01

    Full Text Available Deep unsupervised learning in stochastic recurrent neural networks with many layers of hidden units is a recent breakthrough in neural computation research. These networks build a hierarchy of progressively more complex distributed representations of the sensory data by fitting a hierarchical generative model. In this article we discuss the theoretical foundations of this approach and we review key issues related to training, testing and analysis of deep networks for modeling language and cognitive processing. The classic letter and word perception problem of McClelland and Rumelhart (1981 is used as a tutorial example to illustrate how structured and abstract representations may emerge from deep generative learning. We argue that the focus on deep architectures and generative (rather than discriminative learning represents a crucial step forward for the connectionist modeling enterprise, because it offers a more plausible model of cortical learning as well as way to bridge the gap between emergentist connectionist models and structured Bayesian models of cognition.

  2. Modeling language and cognition with deep unsupervised learning: a tutorial overview

    Science.gov (United States)

    Zorzi, Marco; Testolin, Alberto; Stoianov, Ivilin P.

    2013-01-01

    Deep unsupervised learning in stochastic recurrent neural networks with many layers of hidden units is a recent breakthrough in neural computation research. These networks build a hierarchy of progressively more complex distributed representations of the sensory data by fitting a hierarchical generative model. In this article we discuss the theoretical foundations of this approach and we review key issues related to training, testing and analysis of deep networks for modeling language and cognitive processing. The classic letter and word perception problem of McClelland and Rumelhart (1981) is used as a tutorial example to illustrate how structured and abstract representations may emerge from deep generative learning. We argue that the focus on deep architectures and generative (rather than discriminative) learning represents a crucial step forward for the connectionist modeling enterprise, because it offers a more plausible model of cortical learning as well as a way to bridge the gap between emergentist connectionist models and structured Bayesian models of cognition. PMID:23970869

  3. Conformational Sampling in Template-Free Protein Loop Structure Modeling: An Overview

    OpenAIRE

    Li, Yaohang

    2013-01-01

    Accurately modeling protein loops is an important step to predict three-dimensional structures as well as to understand functions of many proteins. Because of their high flexibility, modeling the three-dimensional structures of loops is difficult and is usually treated as a “mini protein folding problem” under geometric constraints. In the past decade, there has been remarkable progress in template-free loop structure modeling due to advances of computational methods as well as stably increas...

  4. Dynamics of Zika virus outbreaks: an overview of mathematical modeling approaches.

    Science.gov (United States)

    Wiratsudakul, Anuwat; Suparit, Parinya; Modchang, Charin

    2018-01-01

    The Zika virus was first discovered in 1947. It was neglected until a major outbreak occurred on Yap Island, Micronesia, in 2007. Teratogenic effects resulting in microcephaly in newborn infants is the greatest public health threat. In 2016, the Zika virus epidemic was declared as a Public Health Emergency of International Concern (PHEIC). Consequently, mathematical models were constructed to explicitly elucidate related transmission dynamics. In this review article, two steps of journal article searching were performed. First, we attempted to identify mathematical models previously applied to the study of vector-borne diseases using the search terms "dynamics," "mathematical model," "modeling," and "vector-borne" together with the names of vector-borne diseases including chikungunya, dengue, malaria, West Nile, and Zika. Then the identified types of model were further investigated. Second, we narrowed down our survey to focus on only Zika virus research. The terms we searched for were "compartmental," "spatial," "metapopulation," "network," "individual-based," "agent-based" AND "Zika." All relevant studies were included regardless of the year of publication. We have collected research articles that were published before August 2017 based on our search criteria. In this publication survey, we explored the Google Scholar and PubMed databases. We found five basic model architectures previously applied to vector-borne virus studies, particularly in Zika virus simulations. These include compartmental, spatial, metapopulation, network, and individual-based models. We found that Zika models carried out for early epidemics were mostly fit into compartmental structures and were less complicated compared to the more recent ones. Simple models are still commonly used for the timely assessment of epidemics. Nevertheless, due to the availability of large-scale real-world data and computational power, recently there has been growing interest in more complex modeling frameworks

  5. Stereotactic treatment. Definitions and literature overview

    International Nuclear Information System (INIS)

    Fontenla, D.P.

    2008-01-01

    The topics discussed include, among others, the following: Radiosurgery definitions; Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT); Available uncertainties in SRS; Gamma knife; Linac-based SRS; Components of a radiosurgery system; Stereotactic hardware (brain lab); m3 linac attachment; Radiosurgery - clinical procedure; Cancer management; Rationale for SRT; Role of radiosurgery in the management of intracranial tumors; Indications for stereotactic SRS/SRT; Physical components required for SRS/SRT; Stereotactic patient set-up; Stereotactic CT scan for SRS; Physical components required for SRT: Relocatable head frame (GTC); Patient immobilization; Treatment planning system; Basic requirements for SRS dosimetry (Linac based); Stereotactic set-up QA (Linac); Stereotactic frames and QA; Beam dose measurements; Dose evaluation tools; Phantoms. (P.A.)

  6. Mantle cell lymphoma-current literature overview.

    Science.gov (United States)

    Pejcic, Ivica; Petkovic, Ivan; Vrbic, Svetislav; Filipovic, Sladjana; Balic, Mirjana; Cvetanovic, Ana

    2014-01-01

    Mantle cell lymphoma (MCL) is a distinct subtype of lymphoma identified as a particular entity in the early 1990s. The prognosis of MCL is generally poor, and is considered one of the worst among all B-cell lymphomas. In general, conventional chemotherapy is only palliative and the median duration of remissions is only 1-2 years. With the exception of allogeneic hematopoietic stem cell transplantation (allo-SCT), current treatment approaches are not curative and the corresponding survival curve is characterized by a relatively steep and continuous decline, with a median survival of about 4 years and watch and wait strategy. Optimal first-line therapy in MCL is not established yet. Very intensive regimens, including autologous (auto-SCT) and allo-SCT, seem to be required to improve the outcome. Allogeneic stem cell transplantation is the only therapy that can achieve a plateau in the survival curve, but, however, it is not applicable in most of the cases due to the patients' older age when the disease mostly occurs. Molecular knowledge of MCL has progressed and therefore a large number of molecular targeted therapies have been introduced in relapsed and refractory disease.

  7. An Overview of Modeling Approaches Applied to Aggregation-Based Fleet Management and Integration of Plug-in Electric Vehicles †

    DEFF Research Database (Denmark)

    You, Shi; Hu, Junjie; Ziras, Charalampos

    2016-01-01

    The design and implementation of management policies for plug-in electric vehicles (PEVs) need to be supported by a holistic understanding of the functional processes, their complex interactions, and their response to various changes. Models developed to represent different functional processes...... and systems are seen as useful tools to support the related studies for different stakeholders in a tangible way. This paper presents an overview of modeling approaches applied to support aggregation-based management and integration of PEVs from the perspective of fleet operators and grid operators......, respectively. We start by explaining a structured modeling approach, i.e., a flexible combination of process models and system models, applied to different management and integration studies. A state-of-the-art overview of modeling approaches applied to represent several key processes, such as charging...

  8. The Agricultural Model Intercomparison and Improvement Project (AgMIP): Overview and Progress

    Science.gov (United States)

    Rosenzweig, C.; Hatfield, J.; Jones, J. W.; Ruane, A. C.

    2012-12-01

    The Agricultural Model Intercomparison and Improvement Project (AgMIP) is an international effort to assess the state of global agricultural modeling and to understand climate impacts on the agricultural sector. AgMIP connects the climate science, crop modeling, and agricultural economic modeling communities to generate probabilistic projections of current and future climate impacts. The goals of AgMIP are to improve substantially the characterization of risk of hunger and world food security due to climate change and to enhance adaptation capacity in both developing and developed countries. This presentation will describe the general approach of AgMIP and highlight its findings and activities. AgMIP crop model intercomparisons have been established for wheat (27 models participating), maize (25 models), and rice (15+ models), and are being established for sugarcane, soybean, sorghum/millet, and peanut. In coordination with these pilots, methodologies to utilize weather generators and downscaled climate simulations for agricultural applications are under development. An AgMIP global agricultural economics model intercomparison with participation of 11 international groups is ongoing, and a number of global biophysical models are currently being evaluated for future climate impacts on agricultural lands both as part of the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP) and for contribution to the IPCC Fifth Assessment Report (AR5). AgMIP is also organizing regional research efforts, and has already held workshops in South America, Sub-Saharan Africa, South Asia, Europe, and North America. Outcomes from these meetings have informed AgMIP activities, and 10 research teams from Sub-Saharan Africa and South Asia have been selected for project funding. Additional activities are planned for Australia and East Asia. As the AgMIP research community continues to work towards its goals, three key cross-cutting scientific challenges have emerged and are being

  9. Overview and application of the Model Optimization, Uncertainty, and SEnsitivity Analysis (MOUSE) toolbox

    Science.gov (United States)

    For several decades, optimization and sensitivity/uncertainty analysis of environmental models has been the subject of extensive research. Although much progress has been made and sophisticated methods developed, the growing complexity of environmental models to represent real-world systems makes it...

  10. Nitrogen dynamics in flooded soil systems: An overview on concepts and performance of models

    NARCIS (Netherlands)

    Khairudin, Nurul; Gaydon, Donald S.; Jing, Qi; Zakaria, Mohamad P.; Struik, Paul C.; Keesman, Karel J.

    2018-01-01

    Extensive modelling studies on nitrogen (N) dynamics in flooded soil systems have been published. Consequently, many N dynamics models are available for users to select from. With the current research trend, inclined towards multi-disciplinary research, and with substantial progress in understanding

  11. Overview of data-synthesis in systematic reviews of studies on outcome prediction models

    NARCIS (Netherlands)

    T. van den Berg (Tobias); M.W. Heymans (Martijn); O. Leone; D. Vergouw (David); J. Hayden (Jill); A.P. Verhagen (Arianne); H.C. de Vet (Henrica C)

    2013-01-01

    textabstractBackground: Many prognostic models have been developed. Different types of models, i.e. prognostic factor and outcome prediction studies, serve different purposes, which should be reflected in how the results are summarized in reviews. Therefore we set out to investigate how authors of

  12. Verification of Decision-Analytic Models for Health Economic Evaluations: An Overview.

    Science.gov (United States)

    Dasbach, Erik J; Elbasha, Elamin H

    2017-07-01

    Decision-analytic models for cost-effectiveness analysis are developed in a variety of software packages where the accuracy of the computer code is seldom verified. Although modeling guidelines recommend using state-of-the-art quality assurance and control methods for software engineering to verify models, the fields of pharmacoeconomics and health technology assessment (HTA) have yet to establish and adopt guidance on how to verify health and economic models. The objective of this paper is to introduce to our field the variety of methods the software engineering field uses to verify that software performs as expected. We identify how many of these methods can be incorporated in the development process of decision-analytic models in order to reduce errors and increase transparency. Given the breadth of methods used in software engineering, we recommend a more in-depth initiative to be undertaken (e.g., by an ISPOR-SMDM Task Force) to define the best practices for model verification in our field and to accelerate adoption. Establishing a general guidance for verifying models will benefit the pharmacoeconomics and HTA communities by increasing accuracy of computer programming, transparency, accessibility, sharing, understandability, and trust of models.

  13. An overview of biosphere modelling for the assessment of solid waste disposal

    International Nuclear Information System (INIS)

    Smith, G.M.

    1990-01-01

    The purpose of this paper is to discuss the role of biosphere modelling in relation to the overall assessment of disposal of solid radioactive waste. Model structure and data requirements are strongly influenced by a number of basic factors. Firstly, the alternative forms of safety criteria and regulatory requirements imply different end-points for biosphere models. Secondly, alternative disposal concepts can influence the significance of the biosphere as a barrier or diluting/concentrating feature affecting exposure of man. Thirdly, the range of different possibilities for release to the biosphere, including releases following intrusion, is very extensive. The requirements and state of development of biosphere models are discussed in relation to these factors along with methods being adopted to provide some expression of confidence in model results. 37 refs

  14. The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol.

    Science.gov (United States)

    Osier, Nicole; Dixon, C Edward

    2016-01-01

    Controlled cortical impact (CCI) is a commonly used and highly regarded model of brain trauma that uses a pneumatically or electromagnetically controlled piston to induce reproducible and well-controlled injury. The CCI model was originally used in ferrets and it has since been scaled for use in many other species. This chapter will describe the historical development of the CCI model, compare and contrast the pneumatic and electromagnetic models, and summarize key short- and long-term consequences of TBI that have been gleaned using this model. In accordance with the recent efforts to promote high-quality evidence through the reporting of common data elements (CDEs), relevant study details-that should be reported in CCI studies-will be noted.

  15. A Systematic Review of Perennial Staple Crops Literature Using Topic Modeling and Bibliometric Analysis

    Science.gov (United States)

    2016-01-01

    Research on perennial staple crops has increased in the past ten years due to their potential to improve ecosystem services in agricultural systems. However, multiple past breeding efforts as well as research on traditional ratoon systems mean there is already a broad body of literature on perennial crops. In this review, we compare the development of research on perennial staple crops, including wheat, rice, rye, sorghum, and pigeon pea. We utilized the advanced search capabilities of Web of Science, Scopus, ScienceDirect, and Agricola to gather a library of 914 articles published from 1930 to the present. We analyzed the metadata in the entire library and in collections of literature on each crop to understand trends in research and publishing. In addition, we applied topic modeling to the article abstracts, a type of text analysis that identifies frequently co-occurring terms and latent topics. We found: 1.) Research on perennials is increasing overall, but individual crops have each seen periods of heightened interest and research activity; 2.) Specialist journals play an important role in supporting early research efforts. Research often begins within communities of specialists or breeders for the individual crop before transitioning to a more general scientific audience; 3.) Existing perennial agricultural systems and their domesticated crop material, such as ratoon rice systems, can provide a useful foundation for breeding efforts, accelerating the development of truly perennial crops and farming systems; 4.) Primary research is lacking for crops that are produced on a smaller scale globally, such as pigeon pea and sorghum, and on the ecosystem service benefits of perennial agricultural systems. PMID:27213283

  16. Overview of past, ongoing and future efforts of the integrated modeling of global change for Northern Eurasia

    Science.gov (United States)

    Monier, Erwan; Kicklighter, David; Sokolov, Andrei; Zhuang, Qianlai; Melillo, Jerry; Reilly, John

    2016-04-01

    Northern Eurasia is both a major player in the global carbon budget (it includes roughly 70% of the Earth's boreal forest and more than two-thirds of the Earth's permafrost) and a region that has experienced dramatic climate change (increase in temperature, growing season length, floods and droughts) over the past century. Northern Eurasia has also undergone significant land-use change, both driven by human activity (including deforestation, expansion of agricultural lands and urbanization) and natural disturbances (such as wildfires and insect outbreaks). These large environmental and socioeconomic impacts have major implications for the carbon cycle in the region. Northern Eurasia is made up of a diverse set of ecosystems that range from tundra to forests, with significant areas of croplands and pastures as well as deserts, with major urban areas. As such, it represents a complex system with substantial challenges for the modeling community. In this presentation, we provide an overview of past, ongoing and possible future efforts of the integrated modeling of global change for Northern Eurasia. We review the variety of existing modeling approaches to investigate specific components of Earth system dynamics in the region. While there are a limited number of studies that try to integrate various aspects of the Earth system (through scale, teleconnections or processes), we point out that there are few systematic analyses of the various feedbacks within the Earth system (between components, regions or scale). As a result, there is a lack of knowledge of the relative importance of such feedbacks, and it is unclear how policy relevant current studies are that fail to account for these feedbacks. We review the role of Earth system models, and their advantages/limitations compared to detailed single component models. We further introduce the human activity system (global trade, economic models, demographic model and so on), the need for coupled human/earth system models

  17. Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

    Directory of Open Access Journals (Sweden)

    Anjar Priyono

    2016-11-01

    Full Text Available Purpose: Disassembly is an important process that distinguishes remanufacturing from conventional manufacturing. It is a unique process that becomes focus of investigation from many scholars. Yet, most scholars investigate disassembly from technical and operational standpoint that lack of strategic perspective. This paper attempts to fill this gap by looking at disassembly from a strategic perspective by considering organisational characteristics, process choices and product attributes. To be more specific, this paper has three objectives. First, to gain understanding what has been done, and what need to be done in the field of disassembly in remanufacturing. Second, to conduct a systematic literature review for identifying the factors affecting disassembly for remanufacturing. Third, to propose a new model of disassembly for remanufacturing and also to provide avenues for future research. Design/methodology/approach: This study used a systematic literature review method. A series of steps were undertaken during the review. The study was started with determining the purpose of the study, selecting appropriate keywords, and reducing the selected papers using a number of criteria. A deeper analysis was carried out on the final paper that meets the criteria for this review. Findings: There are two main findings of this study. First, a list of factors affecting disassembly in remanufacturing is identified. The factors can be categorised into three groups: organisational factors, process choices and product attributes. Second, using factors that have been identified, a new model of disassembly process for remanufacturing is developed. Current studies only consider disassembly as a physical activity to break down products into components. In the new model, disassembly is viewed as a process that converts into into output, which consist of a series of steps. Research limitations/implications: The opportunities for future research include: the need to

  18. Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

    International Nuclear Information System (INIS)

    Priyono, A.; Ijomah, W.; Bititci, U.

    2016-01-01

    Purpose: Disassembly is an important process that distinguishes remanufacturing from conventional manufacturing. It is a unique process that becomes focus of investigation from many scholars. Yet, most scholars investigate disassembly from technical and operational standpoint that lack of strategic perspective. This paper attempts to fill this gap by looking at disassembly from a strategic perspective by considering organisational characteristics, process choices and product attributes. To be more specific, this paper has three objectives. First, to gain understanding what has been done, and what need to be done in the field of disassembly in remanufacturing. Second, to conduct a systematic literature review for identifying the factors affecting disassembly for remanufacturing. Third, to propose a new model of disassembly for remanufacturing and also to provide avenues for future research. Design/methodology/approach: This study used a systematic literature review method. A series of steps were undertaken during the review. The study was started with determining the purpose of the study, selecting appropriate keywords, and reducing the selected papers using a number of criteria. A deeper analysis was carried out on the final paper that meets the criteria for this review. Findings: There are two main findings of this study. First, a list of factors affecting disassembly in remanufacturing is identified. The factors can be categorised into three groups: organisational factors, process choices and product attributes. Second, using factors that have been identified, a new model of disassembly process for remanufacturing is developed. Current studies only consider disassembly as a physical activity to break down products into components. In the new model, disassembly is viewed as a process that converts into into output, which consist of a series of steps. Research limitations/implications: The opportunities for future research include: the need to develop an index of

  19. Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

    Energy Technology Data Exchange (ETDEWEB)

    Priyono, A.; Ijomah, W.; Bititci, U.

    2016-07-01

    Purpose: Disassembly is an important process that distinguishes remanufacturing from conventional manufacturing. It is a unique process that becomes focus of investigation from many scholars. Yet, most scholars investigate disassembly from technical and operational standpoint that lack of strategic perspective. This paper attempts to fill this gap by looking at disassembly from a strategic perspective by considering organisational characteristics, process choices and product attributes. To be more specific, this paper has three objectives. First, to gain understanding what has been done, and what need to be done in the field of disassembly in remanufacturing. Second, to conduct a systematic literature review for identifying the factors affecting disassembly for remanufacturing. Third, to propose a new model of disassembly for remanufacturing and also to provide avenues for future research. Design/methodology/approach: This study used a systematic literature review method. A series of steps were undertaken during the review. The study was started with determining the purpose of the study, selecting appropriate keywords, and reducing the selected papers using a number of criteria. A deeper analysis was carried out on the final paper that meets the criteria for this review. Findings: There are two main findings of this study. First, a list of factors affecting disassembly in remanufacturing is identified. The factors can be categorised into three groups: organisational factors, process choices and product attributes. Second, using factors that have been identified, a new model of disassembly process for remanufacturing is developed. Current studies only consider disassembly as a physical activity to break down products into components. In the new model, disassembly is viewed as a process that converts into into output, which consist of a series of steps. Research limitations/implications: The opportunities for future research include: the need to develop an index of

  20. An overview of the recent advances in delay-time-based maintenance modelling

    International Nuclear Information System (INIS)

    Wang, Wenbin

    2012-01-01

    Industrial plant maintenance is an area which has enormous potential to be improved. It is also an area attracted significant attention from mathematical modellers because of the random phenomenon of plant failures. This paper reviews the recent advances in delay-time-based maintenance modelling, which is one of the mathematical techniques for optimising inspection planning and related problems. The delay-time is a concept that divides a plant failure process into two stages: from new until the point of an identifiable defect, and then from this point to failure. The first stage is called the normal working stage and the second stage is called the failure delay-time stage. If the distributions of the two stages can be quantified, the relationship between the number of failures and the inspection interval can be readily established. This can then be used for optimizing the inspection interval and other related decision variables. In this review, we pay particular attention to new methodological developments and industrial applications of the delay-time-based models over the last few decades. The use of the delay-time concept and modeling techniques in other areas rather than in maintenance is also reviewed. Future research directions are also highlighted. - Highlights: ► Reviewed the recent advances in delay-time-based maintenance models and applications. ► Compared the delay-time-based models with other models. ► Focused on methodologies and applications. ► Pointed out future research directions.

  1. Overview of IMAGE 2.0. An integrated model of climate change and the global environment

    International Nuclear Information System (INIS)

    Alcamo, J.; Battjes, C.; Van den Born, G.J.; Bouwman, A.F.; De Haan, B.J.; Klein Goldewijk, K.; Klepper, O.; Kreileman, G.J.J.; Krol, M.; Leemans, R.; Van Minnen, J.G.; Olivier, J.G.J.; De Vries, H.J.M.; Toet, A.M.C.; Van den Wijngaart, R.A.; Van der Woerd, H.J.; Zuidema, G.

    1995-01-01

    The IMAGE 2.0 model is a multi-disciplinary, integrated model, designed to simulate the dynamics of the global society-biosphere-climate system. In this paper the focus is on the scientific aspects of the model, while another paper in this volume emphasizes its political aspects. The objectives of IMAGE 2.0 are to investigate linkages and feedbacks in the global system, and to evaluate consequences of climate policies. Dynamic calculations are performed to the year 2100, with a spatial scale ranging from grid (0.5x0.5 latitude-longitude) to world political regions, depending on the sub-model. A total of 13 sub-models make up IMAGE 2.0, and they are organized into three fully linked sub-systems: Energy-Industry, Terrestrial Environment, and Atmosphere-Ocean. The fully linked model has been tested against data from 1970 to 1990, and after calibration it can reproduce the following observed trends: regional energy consumption and energy-related emissions, terrestrial flux of carbon dioxide and emissions of greenhouse gases, concentrations of greenhouse gases in the atmosphere, and transformation of land cover. The model can also simulate current zonal average surface and vertical temperatures. 1 fig., 10 refs

  2. Sources and delivery of carbon, nitrogen, and phosphorus to the coastal zone: An overview of global Nutrient Export from Watersheds (NEWS) models and their application

    NARCIS (Netherlands)

    Seitzinger, S.P.; Harrison, J.A.; Dumont, E.L.; Beusen, A.H.W.; Bouwman, A.F.

    2005-01-01

    An overview of the first spatially explicit, multielement (N, P, and C), multiform (dissolved inorganic: DIN, DIP; dissolved organic: DOC, DON, DOP; and particulate: POC, PN, PP) predictive model system of river nutrient export from watersheds (Global Nutrient Export from Watersheds (NEWS)) is

  3. An Overview of Generalized Gamma Mittag–Leffler Model and Its Applications

    Directory of Open Access Journals (Sweden)

    Seema S. Nair

    2015-08-01

    Full Text Available Recently, probability models with thicker or thinner tails have gained more importance among statisticians and physicists because of their vast applications in random walks, Lévi flights, financial modeling, etc. In this connection, we introduce here a new family of generalized probability distributions associated with the Mittag–Leffler function. This family gives an extension to the generalized gamma family, opens up a vast area of potential applications and establishes connections to the topics of fractional calculus, nonextensive statistical mechanics, Tsallis statistics, superstatistics, the Mittag–Leffler stochastic process, the Lévi process and time series. Apart from examining the properties, the matrix-variate analogue and the connection to fractional calculus are also explained. By using the pathway model of Mathai, the model is further generalized. Connections to Mittag–Leffler distributions and corresponding autoregressive processes are also discussed.

  4. Pathway models for analysing and managing the introduction of alien plant pests - an overview and categorization

    NARCIS (Netherlands)

    Douma, J.C.; Pautasso, M.; Venette, R.C.; Robinet, C.; Hemerik, L.; Mourits, M.C.M.; Schans, J.; Werf, van der W.

    2016-01-01

    Alien plant pests are introduced into new areas at unprecedented rates through global trade, transport, tourism and travel, threatening biodiversity and agriculture. Increasingly, the movement and introduction of pests is analysed with pathway models to provide risk managers with quantitative

  5. Overview of en route noise prediction using a integrated noise model

    Science.gov (United States)

    2010-04-20

    En route aircraft noise is often ignored in aircraft noise modeling because large amounts of noise attenuation due to long propagation distances between the aircraft and the receivers on the ground, reduced power in cruise flight compared to takeoff ...

  6. Global Overview of the Models of Physiotherapy Practice: A need for ...

    African Journals Online (AJOL)

    Bello

    behaviour (operant model) and increasing healthy. 51. AJPARS Vol. .... locally available resources for therapeutic benefits will be .... Operant behavioural therapy, as a sub-unit .... and meta-analysis of randomized controlled trials of cognitive.

  7. Overview of heat transfer and fluid flow problem areas encountered in Stirling engine modeling

    Science.gov (United States)

    Tew, Roy C., Jr.

    1988-01-01

    NASA Lewis Research Center has been managing Stirling engine development programs for over a decade. In addition to contractual programs, this work has included in-house engine testing and development of engine computer models. Attempts to validate Stirling engine computer models with test data have demonstrated that engine thermodynamic losses need better characterization. Various Stirling engine thermodynamic losses and efforts that are underway to characterize these losses are discussed.

  8. Modeling Language and Cognition with Deep Unsupervised Learning:A Tutorial Overview

    OpenAIRE

    Marco eZorzi; Marco eZorzi; Alberto eTestolin; Ivilin Peev Stoianov; Ivilin Peev Stoianov

    2013-01-01

    Deep unsupervised learning in stochastic recurrent neural networks with many layers of hidden units is a recent breakthrough in neural computation research. These networks build a hierarchy of progressively more complex distributed representations of the sensory data by fitting a hierarchical generative model. In this article we discuss the theoretical foundations of this approach and we review key issues related to training, testing and analysis of deep networks for modeling language and cog...

  9. Modeling language and cognition with deep unsupervised learning: a tutorial overview

    OpenAIRE

    Zorzi, Marco; Testolin, Alberto; Stoianov, Ivilin P.

    2013-01-01

    Deep unsupervised learning in stochastic recurrent neural networks with many layers of hidden units is a recent breakthrough in neural computation research. These networks build a hierarchy of progressively more complex distributed representations of the sensory data by fitting a hierarchical generative model. In this article we discuss the theoretical foundations of this approach and we review key issues related to training, testing and analysis of deep networks for modeling language and cog...

  10. An Overview of the Automated Dispatch Controller Algorithms in the System Advisor Model (SAM)

    Energy Technology Data Exchange (ETDEWEB)

    DiOrio, Nicholas A [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-11-22

    Three automatic dispatch modes have been added to the battery model within the System Adviser Model. These controllers have been developed to perform peak shaving in an automated fashion, providing users with a way to see the benefit of reduced demand charges without manually programming a complicated dispatch control. A flexible input option allows more advanced interaction with the automated controller. This document will describe the algorithms in detail and present brief results on its use and limitations.

  11. Thermodynamic Data for Geochemical Modeling of Carbonate Reactions Associated with CO2 Sequestration – Literature Review

    Energy Technology Data Exchange (ETDEWEB)

    Krupka, Kenneth M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Cantrell, Kirk J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McGrail, B. Peter [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2010-09-01

    Permanent storage of anthropogenic CO2 in deep geologic formations is being considered as a means to reduce the concentration of atmospheric CO2 and thus its contribution to global climate change. To ensure safe and effective geologic sequestration, numerous studies have been completed of the extent to which the CO2 migrates within geologic formations and what physical and geochemical changes occur in these formations when CO2 is injected. Sophisticated, computerized reservoir simulations are used as part of field site and laboratory CO2 sequestration studies. These simulations use coupled multiphase flow-reactive chemical transport models and/or standalone (i.e., no coupled fluid transport) geochemical models to calculate gas solubility, aqueous complexation, reduction/oxidation (redox), and/or mineral solubility reactions related to CO2 injection and sequestration. Thermodynamic data are critical inputs to modeling geochemical processes. The adequacy of thermodynamic data for carbonate compounds has been identified as an important data requirement for the successful application of these geochemical reaction models to CO2 sequestration. A review of thermodynamic data for CO2 gas and carbonate aqueous species and minerals present in published data compilations and databases used in geochemical reaction models was therefore completed. Published studies that describe mineralogical analyses from CO2 sequestration field and natural analogue sites and laboratory studies were also reviewed to identify specific carbonate minerals that are important to CO2 sequestration reactions and therefore require thermodynamic data. The results of the literature review indicated that an extensive thermodynamic database exists for CO2 and CH4 gases, carbonate aqueous species, and carbonate minerals. Values of ΔfG298° and/or log Kr,298° are available for essentially all of these compounds. However, log Kr,T° or heat capacity values at temperatures above 298 K exist for less than

  12. Understanding brittle deformation at the Olkiluoto site. Literature compilation for site characterization and geological modelling

    International Nuclear Information System (INIS)

    Millnes, A.G.

    2006-07-01

    The present report arose from the belief that geological modelling at Olkiluoto, Finland, where an underground repository for spent nuclear fuel is at present under construction, could be significantly improved by an increased understanding of the phenomena being modelled, in conjunction with the more sophisticated data acquisition and processing methods which are now being introduced. Since the geological model is the necessary basis for the rock engineering and hydrological models, which in turn provide the foundation for identifying suitable rock volumes underground and for demonstrating longterm safety, its scientific basis is of critical importance. As a contribution to improving this scientific basis, the literature on brittle deformation in the Earth's crust has been reviewed, and key references chosen and arranged, with the particular geology of the Olkiluoto site in mind. The result is a compilation of scientific articles, reports and books on some of the key topics, which are of significance for an improved understanding of brittle deformation of hard, crystalline rocks, such as those typical for Olkiluoto. The report is subdivided into six Chapters, covering (1) background information, (2) important aspects of the fabric of intact rock, (3) fracture mechanics and brittle microtectonics, (4) fracture data acquisition and processing, for the statistical characterisation and modelling of fracture systems, (5) the characterisation of brittle deformation zones for deterministic modelling, and (6) the regional geological framework of the Olkiluoto site. The Chapters are subdivided into a number of Sections, and each Section into a number of Topics. The citations are mainly collected under each Topic, embedded in a short explanatory text or listed chronologically without comment. The systematic arrangement of Chapters, Sections and Topics is such that the Table of Contents can be used to focus quickly on the theme of interest without the necessity of looking

  13. Thermodynamic Data for Geochemical Modeling of Carbonate Reactions Associated with CO2 Sequestration - Literature Review

    International Nuclear Information System (INIS)

    Krupka, Kenneth M.; Cantrell, Kirk J.; McGrail, B. Peter

    2010-01-01

    Permanent storage of anthropogenic CO 2 in deep geologic formations is being considered as a means to reduce the concentration of atmospheric CO 2 and thus its contribution to global climate change. To ensure safe and effective geologic sequestration, numerous studies have been completed of the extent to which the CO 2 migrates within geologic formations and what physical and geochemical changes occur in these formations when CO 2 is injected. Sophisticated, computerized reservoir simulations are used as part of field site and laboratory CO 2 sequestration studies. These simulations use coupled multiphase flow-reactive chemical transport models and/or standalone (i.e., no coupled fluid transport) geochemical models to calculate gas solubility, aqueous complexation, reduction/oxidation (redox), and/or mineral solubility reactions related to CO 2 injection and sequestration. Thermodynamic data are critical inputs to modeling geochemical processes. The adequacy of thermodynamic data for carbonate compounds has been identified as an important data requirement for the successful application of these geochemical reaction models to CO 2 sequestration. A review of thermodynamic data for CO 2 gas and carbonate aqueous species and minerals present in published data compilations and databases used in geochemical reaction models was therefore completed. Published studies that describe mineralogical analyses from CO 2 sequestration field and natural analogue sites and laboratory studies were also reviewed to identify specific carbonate minerals that are important to CO 2 sequestration reactions and therefore require thermodynamic data. The results of the literature review indicated that an extensive thermodynamic database exists for CO 2 and CH 4 gases, carbonate aqueous species, and carbonate minerals. Values of Δ f G 298 o and/or log K r,298 o are available for essentially all of these compounds. However, log K r,T o or heat capacity values at temperatures above 298 K exist

  14. [Medical human resources planning in Europe: A literature review of the forecasting models].

    Science.gov (United States)

    Benahmed, N; Deliège, D; De Wever, A; Pirson, M

    2018-02-01

    Healthcare is a labor-intensive sector in which half of the expenses are dedicated to human resources. Therefore, policy makers, at national and internal levels, attend to the number of practicing professionals and the skill mix. This paper aims to analyze the European forecasting model for supply and demand of physicians. To describe the forecasting tools used for physician planning in Europe, a grey literature search was done in the OECD, WHO, and European Union libraries. Electronic databases such as Pubmed, Medine, Embase and Econlit were also searched. Quantitative methods for forecasting medical supply rely mainly on stock-and-flow simulations and less often on systemic dynamics. Parameters included in forecasting models exhibit wide variability for data availability and quality. The forecasting of physician needs is limited to healthcare consumption and rarely considers overall needs and service targets. Besides quantitative methods, horizon scanning enables an evaluation of the changes in supply and demand in an uncertain future based on qualitative techniques such as semi-structured interviews, Delphi Panels, or focus groups. Finally, supply and demand forecasting models should be regularly updated. Moreover, post-hoc analyze is also needed but too rarely implemented. Medical human resource planning in Europe is inconsistent. Political implementation of the results of forecasting projections is essential to insure efficient planning. However, crucial elements such as mobility data between Member States are poorly understood, impairing medical supply regulation policies. These policies are commonly limited to training regulations, while horizontal and vertical substitution is less frequently taken into consideration. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  15. Measurement of thermal conductivity and diffusivity in situ: Literature survey and theoretical modelling of measurements

    Energy Technology Data Exchange (ETDEWEB)

    Kukkonen, I.; Suppala, I. [Geological Survey of Finland, Espoo (Finland)

    1999-01-01

    In situ measurements of thermal conductivity and diffusivity of bedrock were investigated with the aid of a literature survey and theoretical simulations of a measurement system. According to the surveyed literature, in situ methods can be divided into `active` drill hole methods, and `passive` indirect methods utilizing other drill hole measurements together with cutting samples and petrophysical relationships. The most common active drill hole method is a cylindrical heat producing probe whose temperature is registered as a function of time. The temperature response can be calculated and interpreted with the aid of analytical solutions of the cylindrical heat conduction equation, particularly the solution for an infinite perfectly conducting cylindrical probe in a homogeneous medium, and the solution for a line source of heat in a medium. Using both forward and inverse modellings, a theoretical measurement system was analysed with an aim at finding the basic parameters for construction of a practical measurement system. The results indicate that thermal conductivity can be relatively well estimated with borehole measurements, whereas thermal diffusivity is much more sensitive to various disturbing factors, such as thermal contact resistance and variations in probe parameters. In addition, the three-dimensional conduction effects were investigated to find out the magnitude of axial `leak` of heat in long-duration experiments. The radius of influence of a drill hole measurement is mainly dependent on the duration of the experiment. Assuming typical conductivity and diffusivity values of crystalline rocks, the measurement yields information within less than a metre from the drill hole, when the experiment lasts about 24 hours. We propose the following factors to be taken as basic parameters in the construction of a practical measurement system: the probe length 1.5-2 m, heating power 5-20 Wm{sup -1}, temperature recording with 5-7 sensors placed along the probe, and

  16. Measurement of thermal conductivity and diffusivity in situ: Literature survey and theoretical modelling of measurements

    International Nuclear Information System (INIS)

    Kukkonen, I.; Suppala, I.

    1999-01-01

    In situ measurements of thermal conductivity and diffusivity of bedrock were investigated with the aid of a literature survey and theoretical simulations of a measurement system. According to the surveyed literature, in situ methods can be divided into 'active' drill hole methods, and 'passive' indirect methods utilizing other drill hole measurements together with cutting samples and petrophysical relationships. The most common active drill hole method is a cylindrical heat producing probe whose temperature is registered as a function of time. The temperature response can be calculated and interpreted with the aid of analytical solutions of the cylindrical heat conduction equation, particularly the solution for an infinite perfectly conducting cylindrical probe in a homogeneous medium, and the solution for a line source of heat in a medium. Using both forward and inverse modellings, a theoretical measurement system was analysed with an aim at finding the basic parameters for construction of a practical measurement system. The results indicate that thermal conductivity can be relatively well estimated with borehole measurements, whereas thermal diffusivity is much more sensitive to various disturbing factors, such as thermal contact resistance and variations in probe parameters. In addition, the three-dimensional conduction effects were investigated to find out the magnitude of axial 'leak' of heat in long-duration experiments. The radius of influence of a drill hole measurement is mainly dependent on the duration of the experiment. Assuming typical conductivity and diffusivity values of crystalline rocks, the measurement yields information within less than a metre from the drill hole, when the experiment lasts about 24 hours. We propose the following factors to be taken as basic parameters in the construction of a practical measurement system: the probe length 1.5-2 m, heating power 5-20 Wm -1 , temperature recording with 5-7 sensors placed along the probe, and

  17. The SCEC Community Modeling Environment (SCEC/CME) - An Overview of its Architecture and Current Capabilities

    Science.gov (United States)

    Maechling, P. J.; Jordan, T. H.; Minster, B.; Moore, R.; Kesselman, C.; SCEC ITR Collaboration

    2004-12-01

    The Southern California Earthquake Center (SCEC), in collaboration with the San Diego Supercomputer Center, the USC Information Sciences Institute, the Incorporated Research Institutions for Seismology, and the U.S. Geological Survey, is developing the Southern California Earthquake Center Community Modeling Environment (CME) under a five-year grant from the National Science Foundation's Information Technology Research (ITR) Program jointly funded by the Geosciences and Computer and Information Science & Engineering Directorates. The CME system is an integrated geophysical simulation modeling framework that automates the process of selecting, configuring, and executing models of earthquake systems. During the Project's first three years, we have performed fundamental geophysical and information technology research and have also developed substantial system capabilities, software tools, and data collections that can help scientist perform systems-level earthquake science. The CME system provides collaborative tools to facilitate distributed research and development. These collaborative tools are primarily communication tools, providing researchers with access to information in ways that are convenient and useful. The CME system provides collaborators with access to significant computing and storage resources. The computing resources of the Project include in-house servers, Project allocations on USC High Performance Computing Linux Cluster, as well as allocations on NPACI Supercomputers and the TeraGrid. The CME system provides access to SCEC community geophysical models such as the Community Velocity Model, Community Fault Model, Community Crustal Motion Model, and the Community Block Model. The organizations that develop these models often provide access to them so it is not necessary to use the CME system to access these models. However, in some cases, the CME system supplements the SCEC community models with utility codes that make it easier to use or access

  18. Mathematical Modeling of Protein Misfolding Mechanisms in Neurological Diseases: A Historical Overview.

    Science.gov (United States)

    Carbonell, Felix; Iturria-Medina, Yasser; Evans, Alan C

    2018-01-01

    Protein misfolding refers to a process where proteins become structurally abnormal and lose their specific 3-dimensional spatial configuration. The histopathological presence of misfolded protein (MP) aggregates has been associated as the primary evidence of multiple neurological diseases, including Prion diseases, Alzheimer's disease, Parkinson's disease, and Creutzfeldt-Jacob disease. However, the exact mechanisms of MP aggregation and propagation, as well as their impact in the long-term patient's clinical condition are still not well understood. With this aim, a variety of mathematical models has been proposed for a better insight into the kinetic rate laws that govern the microscopic processes of protein aggregation. Complementary, another class of large-scale models rely on modern molecular imaging techniques for describing the phenomenological effects of MP propagation over the whole brain. Unfortunately, those neuroimaging-based studies do not take full advantage of the tremendous capabilities offered by the chemical kinetics modeling approach. Actually, it has been barely acknowledged that the vast majority of large-scale models have foundations on previous mathematical approaches that describe the chemical kinetics of protein replication and propagation. The purpose of the current manuscript is to present a historical review about the development of mathematical models for describing both microscopic processes that occur during the MP aggregation and large-scale events that characterize the progression of neurodegenerative MP-mediated diseases.

  19. Post-traumatic stress disorder and beyond: an overview of rodent stress models.

    Science.gov (United States)

    Schöner, Johanna; Heinz, Andreas; Endres, Matthias; Gertz, Karen; Kronenberg, Golo

    2017-10-01

    Post-traumatic stress disorder (PTSD) is a psychiatric disorder of high prevalence and major socioeconomic impact. Patients suffering from PTSD typically present intrusion and avoidance symptoms and alterations in arousal, mood and cognition that last for more than 1 month. Animal models are an indispensable tool to investigate underlying pathophysiological pathways and, in particular, the complex interplay of neuroendocrine, genetic and environmental factors that may be responsible for PTSD induction. Since the 1960s, numerous stress paradigms in rodents have been developed, based largely on Seligman's seminal formulation of 'learned helplessness' in canines. Rodent stress models make use of physiological or psychological stressors such as foot shock, underwater trauma, social defeat, early life stress or predator-based stress. Apart from the brief exposure to an acute stressor, chronic stress models combining a succession of different stressors for a period of several weeks have also been developed. Chronic stress models in rats and mice may elicit characteristic PTSD-like symptoms alongside, more broadly, depressive-like behaviours. In this review, the major existing rodent models of PTSD are reviewed in terms of validity, advantages and limitations; moreover, significant results and implications for future research-such as the role of FKBP5, a mediator of the glucocorticoid stress response and promising target for therapeutic interventions-are discussed. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  20. Dynamic model reduction: An overview of available techniques with application to power systems

    Directory of Open Access Journals (Sweden)

    Đukić Savo D.

    2012-01-01

    Full Text Available This paper summarises the model reduction techniques used for the reduction of large-scale linear and nonlinear dynamic models, described by the differential and algebraic equations that are commonly used in control theory. The groups of methods discussed in this paper for reduction of the linear dynamic model are based on singular perturbation analysis, modal analysis, singular value decomposition, moment matching and methods based on a combination of singular value decomposition and moment matching. Among the nonlinear dynamic model reduction methods, proper orthogonal decomposition, the trajectory piecewise linear method, balancing-based methods, reduction by optimising system matrices and projection from a linearised model, are described. Part of the paper is devoted to the techniques commonly used for reduction (equivalencing of large-scale power systems, which are based on coherency, synchrony, singular perturbation analysis, modal analysis and identification. Two (most interesting of the described techniques are applied to the reduction of the commonly used New England 10-generator, 39-bus test power system.

  1. Breast sarcomas. Literature review

    Directory of Open Access Journals (Sweden)

    D. A. Ryabchikov

    2014-01-01

    Full Text Available The article presents an overview of the literature about breast sarcomas (nonepithelial malignances. Primary sarcomas are extremely rare, with less than 1 % of all malignant tumors of the breast. Breast carcinomas cause an increased interest of the scientists due to their unique clinical and pathological features and unpredictable prognosis.

  2. Valuation of exploration and production assets. An overview of real options models

    International Nuclear Information System (INIS)

    Dias, Marco Antonio Guimaraes

    2004-01-01

    This paper presents a set of selected real options models to evaluate investments in petroleum exploration and production (E and P) under market and technical uncertainties. First are presented some simple examples to develop the intuition about concepts like option value and optimal option exercise, comparing them with the concepts from the traditional net present value (NPV) criteria. Next, the classical model of Paddock, Siegel and Smith is presented, including a discussion on the practical values for the input parameters. The modeling of oil price uncertainty is presented by comparing some alternative stochastic processes. Other E and P applications discussed here are the selection of mutually exclusive alternatives under uncertainty, the wildcat drilling decision, the appraisal investment decisions, and the analysis of option to expand the production through optional wells

  3. Fission product release modelling for application of fuel-failure monitoring and detection - An overview

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, B.J., E-mail: lewibre@gmail.com [Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, K7K 7B4 (Canada); Chan, P.K.; El-Jaby, A. [Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, K7K 7B4 (Canada); Iglesias, F.C.; Fitchett, A. [Candesco Division of Kinectrics Inc., 26 Wellington Street East, 3rd Floor, Toronto, Ontario M5E 1S2 (Canada)

    2017-06-15

    A review of fission product release theory is presented in support of fuel-failure monitoring analysis for the characterization and location of defective fuel. This work is used to describe: (i) the development of the steady-state Visual-DETECT code for coolant activity analysis to characterize failures in the core and the amount of tramp uranium; (ii) a generalization of this model in the STAR code for prediction of the time-dependent release of iodine and noble gas fission products to the coolant during reactor start-up, steady-state, shutdown, and bundle-shifting manoeuvres; (iii) an extension of the model to account for the release of fission products that are delayed-neutron precursors for assessment of fuel-failure location; and (iv) a simplification of the steady-state model to assess the methodology proposed by WANO for a fuel reliability indicator for water-cooled reactors.

  4. Evaluating Models of The Neutral, Barotropic Planetary Boundary Layer using Integral Measures: Part I. Overview

    Science.gov (United States)

    Hess, G. D.; Garratt, J. R.

    Data for the cross-isobaric angle 0, the geostrophic drag coefficient Cg, and the functions A and B of Rossby number similarity theory, obtained from meteorological field experiments, are used to evaluate a range of models of the neutral, barotropic planetary boundary layer. The data give well-defined relationships for 0, Cg, and the integrated dissipation rate over the boundary layer, as a function of the surface Rossby number. Lettau's first-order closure mixing-length model gives an excellent fit to the data; other simple models give reasonable agreement. However more sophisticated models, e.g., higher-order closure, large-eddy simulation, direct numerical simulation and laboratory models, give poor fits to the data. The simplemodels have (at least) one free parameter in their turbulence closure that is matched toatmospheric observations; the more sophisticated models either base their closure onmore general flows or have no free closure parameters. It is suggested that all of theatmospheric experiments that we could locate violate the strict simplifying assumptionsof steady, homogeneous, neutral, barotropic flow required by the sophisticated models.The angle 0 is more sensitive to violations of the assumptions than is Cg.The behaviour of the data varies in three latitude regimes. In middle and high latitudes the observed values of A and B exhibit little latitudinal dependence; the best estimates are A = 1.3 and B = 4.4. In lower latitudes the neutral, barotropic Rossby number theory breaks down. The value of B increases towards the Equator; the determination of A is ambiguous - the trend can increase or decrease towards the Equator. Between approximately 5° and 30° latitude, the scatter in the data is thought to be primarily due to the inherent presence of baroclinicity. The presence of the trade-wind inversion, thermal instability and the horizontal component of the Earth's rotation ΩH also contribute.Marked changes in the values of A and B occur in the

  5. Introductory Overviews

    NARCIS (Netherlands)

    Jakeman, A.J.; Hamilton, S.H.; Athanasiadis, I.N.; Pierce, S.A.

    2015-01-01

    Introductory Overview articles are designed to provide introductory level background to key themes and topics that caters to the eclectic readership of EMS. It is envisaged that these articles will help to break down barriers to shared understanding and dialogue within multidisciplinary teams, and

  6. Conference overview

    Indian Academy of Sciences (India)

    It had 17 plenary talks and as a new feature it also had 8 short talks which ..... absence of black holes, long-term simulations are possible and quantitative .... [3] For a brief overview, see The Nag Memorial Lecture by Ashoke Sen at the Inst-.

  7. Critical overview of all available animal models for abdominal wall hernia research

    NARCIS (Netherlands)

    Vogels, R.R.M.; R. Kaufmann (Ruth); L.C.L. van den Hil (Leontine); van Steensel, S.; M.H.F. Schreinemacher (Marc H.F.); J.F. Lange (Johan); N.D. Kannekens-Bouvy (Nicole)

    2017-01-01

    textabstractPurpose: Since the introduction of the first prosthetic mesh for abdominal hernia repair, there has been a search for the “ideal mesh.” The use of preclinical or animal models for assessment of necessary characteristics of new and existing meshes is an indispensable part of hernia

  8. Robustness studies in covariance structure modeling - An overview and a meta-analysis

    NARCIS (Netherlands)

    Hoogland, Jeffrey J.; Boomsma, A

    In covariance structure modeling, several estimation methods are available. The robustness of an estimator against specific violations of assumptions can be determined empirically by means of a Monte Carlo study. Many such studies in covariance structure analysis have been published, but the

  9. Comprehensive overview of the Point-by-Point model of prompt emission in fission

    Energy Technology Data Exchange (ETDEWEB)

    Tudora, A. [University of Bucharest, Faculty of Physics, Bucharest Magurele (Romania); Hambsch, F.J. [European Commission, Joint Research Centre, Directorate G - Nuclear Safety and Security, Unit G2, Geel (Belgium)

    2017-08-15

    The investigation of prompt emission in fission is very important in understanding the fission process and to improve the quality of evaluated nuclear data required for new applications. In the last decade remarkable efforts were done for both the development of prompt emission models and the experimental investigation of the properties of fission fragments and the prompt neutrons and γ-ray emission. The accurate experimental data concerning the prompt neutron multiplicity as a function of fragment mass and total kinetic energy for {sup 252}Cf(SF) and {sup 235}U(n,f) recently measured at JRC-Geel (as well as other various prompt emission data) allow a consistent and very detailed validation of the Point-by-Point (PbP) deterministic model of prompt emission. The PbP model results describe very well a large variety of experimental data starting from the multi-parametric matrices of prompt neutron multiplicity ν(A,TKE) and γ-ray energy E{sub γ}(A,TKE) which validate the model itself, passing through different average prompt emission quantities as a function of A (e.g., ν(A), E{sub γ}(A), left angle ε right angle (A) etc.), as a function of TKE (e.g., ν(TKE), E{sub γ}(TKE)) up to the prompt neutron distribution P(ν) and the total average prompt neutron spectrum. The PbP model does not use free or adjustable parameters. To calculate the multi-parametric matrices it needs only data included in the reference input parameter library RIPL of IAEA. To provide average prompt emission quantities as a function of A, of TKE and total average quantities the multi-parametric matrices are averaged over reliable experimental fragment distributions. The PbP results are also in agreement with the results of the Monte Carlo prompt emission codes FIFRELIN, CGMF and FREYA. The good description of a large variety of experimental data proves the capability of the PbP model to be used in nuclear data evaluations and its reliability to predict prompt emission data for fissioning

  10. Overview and Evaluation of a Smoke Modeling System and other Tools used during Wildfire Incident Deployments

    Science.gov (United States)

    ONeill, S. M.; Larkin, N. K.; Martinez, M.; Rorig, M.; Solomon, R. C.; Dubowy, J.; Lahm, P. W.

    2017-12-01

    Specialists operationally deployed to wildfires to forecast expected smoke conditions for the public use many tools and information. These Air Resource Advisors (ARAs) are deployed as part of the Wildland Fire Air Quality Response Program (WFAQRP) and rely on smoke models, monitoring data, meteorological information, and satellite information to produce daily Smoke Outlooks for a region impacted by smoke from wildfires. These Smoke Outlooks are distributed to air quality and health agencies, published online via smoke blogs and other social media, and distributed by the Incident Public Information Officer (PIO), and ultimately to the public. Fundamental to these operations are smoke modeling systems such as the BlueSky Smoke Modeling Framework, which combines fire activity information, mapped fuel loadings, consumption and emissions models, and air quality/dispersion models such as HYSPLIT to produce predictions of PM2.5 concentrations downwind of wildland fires. Performance of this system at a variety of meteorological resolutions, fire initialization information, and vertical allocation of emissions is evaluated for the Summer of 2015 when over 400,000 hectares burned in the northwestern US state of Washington and 1-hr average fine particulate matter (PM2.5) concentrations exceeded 700 μg/m3. The performance of the system at the 12-km, 4-km, and 1.33-km resolutions is evaluated using 1-hr average PM2.5 measurements from permanent monitors and temporary monitors deployed specifically for wildfires by ARAs on wildfire incident command teams. At the higher meteorological resolution (1.33-km) the terrain features are more detailed, showing better valley structures and in general, PM2.5 concentrations were greater in the valleys with the 1.33-km meteorological domain than with the 4-km domain.

  11. Coupled Weather and Wildfire Behavior Modeling at Los Alamos: An Overview

    Energy Technology Data Exchange (ETDEWEB)

    Bossert, James E.; Harlow, Francis H.; Linn, Rodman R.; Reisner, Jon M.; White, Andrew B.; Winterkamp, Judith L.

    1997-12-31

    Over the past two years, researchers at Los Alamos National Laboratory (LANL) have been engaged in coupled weather/wildfire modeling as part of a broader initiative to predict the unfolding of crisis events. Wildfire prediction was chosen for the following reasons: (1) few physics-based wild-fire prediction models presently exist; (2) LANL has expertise in the fields required to develop such a capability; and (3) the development of this predictive capability would be enhanced by LANL`s strength in high performance computing. Wildfire behavior models have historically been used to predict fire spread and heat release for a prescribed set of fuel, slope, and wind conditions (Andrews 1986). In the vicinity of a fire, however, atmospheric conditions are constantly changing due to non-local weather influences and the intense heat of the fire itself. This non- linear process underscores the need for physics-based models that treat the atmosphere-fire feedback. Actual wildfire prediction with full-physics models is both time-critical and computationally demanding, since it must include regional- to local-scale weather forecasting together with the capability to accurately simulate both intense gradients across a fireline, and atmosphere/fire/fuel interactions. Los Alamos has recently (January 1997) acquired a number of SGI/Cray Origin 2000 machines, each presently having 32 to 64 processors. These high performance computing systems are part of the Department of Energy`s Accelerated Strategic Computing Initiative (ASCI). While offering impressive performance now, upgrades to the system promise to deliver over 1 Teraflop (10(12) floating point operations per second) at peak performance before the turn of the century.

  12. An Overview of Plume Tracker: Mapping Volcanic Emissions with Interactive Radiative Transfer Modeling

    Science.gov (United States)

    Realmuto, V. J.; Berk, A.; Guiang, C.

    2014-12-01

    Infrared remote sensing is a vital tool for the study of volcanic plumes, and radiative transfer (RT) modeling is required to derive quantitative estimation of the sulfur dioxide (SO2), sulfate aerosol (SO4), and silicate ash (pulverized rock) content of these plumes. In the thermal infrared, we must account for the temperature, emissivity, and elevation of the surface beneath the plume, plume altitude and thickness, and local atmospheric temperature and humidity. Our knowledge of these parameters is never perfect, and interactive mapping allows us to evaluate the impact of these uncertainties on our estimates of plume composition. To enable interactive mapping, the Jet Propulsion Laboratory is collaborating with Spectral Sciences, Inc., (SSI) to develop the Plume Tracker toolkit. This project is funded by a NASA AIST Program Grant (AIST-11-0053) to SSI. Plume Tracker integrates (1) retrieval procedures for surface temperature and emissivity, SO2, NH3, or CH4 column abundance, and scaling factors for H2O vapor and O3 profiles, (2) a RT modeling engine based on MODTRAN, and (3) interactive visualization and analysis utilities under a single graphics user interface. The principal obstacle to interactive mapping is the computational overhead of the RT modeling engine. Under AIST-11-0053 we have achieved a 300-fold increase in the performance of the retrieval procedures through the use of indexed caches of model spectra, optimization of the minimization procedures, and scaling of the effects of surface temperature and emissivity on model radiance spectra. In the final year of AIST-11-0053 we will implement parallel processing to exploit multi-core CPUs and cluster computing, and optimize the RT engine to eliminate redundant calculations when iterating over a range of gas concentrations. These enhancements will result in an additional 8 - 12X increase in performance. In addition to the improvements in performance, we have improved the accuracy of the Plume Tracker

  13. Overview of statistical methods, models and analysis for predicting equipment end of life

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Utility equipment can be operated and maintained for many years following installation. However, as the equipment ages, utility operators must decide whether to extend the service life or replace the equipment. Condition assessment modelling is used by many utilities to determine the condition of equipment and to prioritize the maintenance or repair. Several factors are weighted and combined in assessment modelling, which gives a single index number to rate the equipment. There is speculation that this index alone may not be adequate for a business case to rework or replace an asset because it only ranks an asset into a particular category. For that reason, a new methodology was developed to determine the economic end of life of an asset. This paper described the different statistical methods available and their use in determining the remaining service life of electrical equipment. A newly developed Excel-based demonstration computer tool is also an integral part of the deliverables of this project.

  14. A Critical Overview of Models of Reading Comprehension with a Focus on Cognitive Aspects

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Shahnazari

    2014-09-01

    Full Text Available Abstract Reading is a cognitive activity involving skills, strategies, attentional resources, knowledge resources and their integration. The reader’s role is to decode the written symbols to allow for the recovery of information from long-term memory to construct a plausible interpretation of the writer’s message. Various number of reading models have been proposed by researchers among which some focus on motivational and emotional aspects of reading. Others highlight the cognitive aspects of reading. In this study, the models characterizing reading in terms of cognitive aspects are revieweded, and different viewpoints on the reading process are described. This may help EFL/ESL teachers to improve their understanding of the reading process, update their perspectives on teaching reading tasks which in turn might result in more efficient learning by not putting too much cognitively demanding reading tasks on EFL/ESL learners.

  15. Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview

    Directory of Open Access Journals (Sweden)

    Andrea Matteucci

    2015-01-01

    Full Text Available Experimental models of diabetic retinopathy (DR have had a crucial role in the comprehension of the pathophysiology of the disease and the identification of new therapeutic strategies. Most of these studies have been conducted in vivo, in animal models. However, a significant contribution has also been provided by studies on retinal cultures, especially regarding the effects of the potentially toxic components of the diabetic milieu on retinal cell homeostasis, the characterization of the mechanisms on the basis of retinal damage, and the identification of potentially protective molecules. In this review, we highlight the contribution given by primary retinal cultures to the study of DR, focusing on early neuroglial impairment. We also speculate on possible themes into which studies based on retinal cell cultures could provide deeper insight.

  16. An Overview of the Technical Basis of HENRE 2.0 Models

    Science.gov (United States)

    2015-08-01

    important for estimating health effects, but is also key in developing appropriate guidelines for responders and decontamination protocols. Modeling of...residential buildings (2008-2010). US Department of Homeland Security/US Fire Administration, National Fire Data Center . Topical Fire Report Series... Surgical Research, 61(1), 17-22. Harris, J.W., and Nonan, T.R., 1968. “Early Vascular Permeability Changes in Whole-body X- irradiated Rats,” Radiation

  17. An overview of payment mechanisms and contractual models to support patient-centred care integration

    OpenAIRE

    Kasteng, Frida; Magnusson, Jon; Borgermans, Liesbeth; Kalseth, Jorid

    2016-01-01

    The way health services are paid for will, directly or indirectly, influence what care is provided and the way it is delivered. Many countries are in the process of introducing policies and reforms to enhance collaboration across providers and foster integrated care. Interlinked with ambitions to create more patient-centered care are endeavors to change the health care purchasing model from one based largely on inputs and outputs to one based on outcomes, with the aim of optimising resource u...

  18. An overview of erosion corrosion models and reliability assessment for corrosion defects in piping system

    International Nuclear Information System (INIS)

    Srividya, A.; Suresh, H.N.; Verma, A.K.; Gopika, V.; Santosh

    2006-01-01

    Piping systems are part of passive structural elements in power plants. The analysis of the piping systems and their quantification in terms of failure probability is of utmost importance. The piping systems may fail due to various degradation mechanisms like thermal fatigue, erosion-corrosion, stress corrosion cracking and vibration fatigue. On examination of previous results, erosion corrosion was more prevalent and wall thinning is a time dependent phenomenon. The paper is intended to consolidate the work done by various investigators on erosion corrosion in estimating the erosion corrosion rate and reliability predictions. A comparison of various erosion corrosion models is made. The reliability predictions based on remaining strength of corroded pipelines by wall thinning is also attempted. Variables in the limit state functions are modelled using normal distributions and Reliability assessment is carried out using some of the existing failure pressure models. A steady state corrosion rate is assumed to estimate the corrosion defect and First Order Reliability Method (FORM) is used to find the probability of failure associated with corrosion defects over time using the software for Component Reliability evaluation (COMREL). (author)

  19. Measurements and modelling of atmospheric pollution over the Paris area: an overview of the ESQUIF Project

    Directory of Open Access Journals (Sweden)

    L. Menut

    2000-11-01

    Full Text Available The "Étude et Simulation de la QUalité de l'air en Ile de France" (ESQUIF project is the first integrated project dedicated to the study of the processes leading to air pollution events over the Paris area. The project was carried out over two years (summer 1998 to winter 2000 to document all types of meteorological conditions favourable to air quality degradation, and in particular to photo oxydant formation. The goals of ESQUIF are (1 to improve our understanding of the relevant chemical and dynamical processes and, in turn, improve their parametrizations in numerical models, and (2 to improve and validate existing models dedicated to pollution analysis, scenarios and/or forecasting, by establishing a comprehensive and thorough database. We present the rationale of the ESQUIF project and we describe the experimental set-up. We also report on the first experiments which took place during the summer of 1998 involving surface networks, and remote sensing instruments as well as several aircraft. Focusing on three days of August 1998, the relative contributions of long-range transported and locally-produced ozone to the elevated ozone concentrations observed during this period are discussed and chemistry-transport model preliminary results on this period are compared to measurements.Key words: Atmospheric composition and structure (pollution – urban and regional; troposphere – composition and chemistry – Meteorology and atmospheric dynamics (mesoscale meteorology

  20. Measurements and modelling of atmospheric pollution over the Paris area: an overview of the ESQUIF project

    Energy Technology Data Exchange (ETDEWEB)

    Menut, L; Vautard, R; Flamant, P H [Centre National de Recherche Scientifique (CNRS), 75 - Paris (France). Lab. de Meteorologie Dynamique; Flamant, C; Beekmann, M; Megie, G; Sicard, M [Centre National de la Recherche Scientifique (CNRS), 91 - Verrieres-le-Buisson (France). Service d' Aeronomie; Abonnel, C; Lefebvre, M P; Lossec, B [Meteo-France, 75 - Paris (France); Chazette, P; Martin, D [CNRS (France). Lab. des Sciences du Climat et de l' Environnement; Gombert, D [AIRPARIF, Paris (France); Guedalia, D [CNRS-Universite Paul Sabatier (France). Lab. d' Aerologie; Kley, D [Forschungszentrum Juelich GmbH (Germany); Perros, P; Toupance, G [CNRS (France). Lab. Interuniversitaire des Systemes Atmospheriques

    2000-11-01

    The ''etude et simulation de la qualite de l'air en ile de France'' (ESQUIF) project is the first integrated project dedicated to the study of the processes leading to air pollution events over the Paris area. The project was carried out over two years (summer 1998 to winter 2000) to document all types of meteorological conditions favourable to air quality degradation, and in particular to photo oxydant formation. The goals of ESQUIF are (1) to improve our understanding of the relevant chemical and dynamical processes and, in turn, improve their parametrizations in numerical models, and (2) to improve and validate existing models dedicated to pollution analysis, scenarios and/or forecasting, by establishing a comprehensive and thorough database. We present the rationale of the ESQUIF project and we describe the experimental set-up. We also report on the first experiments which took place during the summer of 1998 involving surface networks, and remote sensing instruments as well as several aircraft. Focusing on three days of August 1998, the relative contributions of long-range transported and locally-produced ozone to the elevated ozone concentrations observed during this period are discussed and chemistry-transport model preliminary results on this period are compared to measurements. (orig.)

  1. Overview of research and development in subsurface fate and transport modeling

    International Nuclear Information System (INIS)

    Sullivan, T.M.; Chehata, M.

    1995-05-01

    The US Department of Energy is responsible for the remediation of over 450 different subsurface-contaminated sites. Contaminant plumes at these sites range in volume from several to millions of cubic yards. The concentration of contaminants also ranges over several orders of magnitude. Contaminants include hazardous wastes such as heavy metals and organic chemicals, radioactive waste including tritium, uranium, and thorium, and mixed waste, which is a combination of hazardous and radioactive wastes. The physical form of the contaminants includes solutes, nonaqueous phase liquids (NAPLs), and vapor phase contaminants such as volatilized organic chemicals and radon. The subject of contaminant fate and transport modeling is multi-disciplinary, involving hydrology, geology, microbiology, chemistry, applied mathematics, computer science, and other areas of expertise. It is an issue of great significance in the United States and around the world. As such, many organizations have substantial programs in this area. In gathering data to prepare this report, a survey was performed of research and development work that is funded by US government agencies to improve the understanding and mechanistic modeling of processes that control contaminant movement through subsurface systems. Government agencies which fund programs that contain fate and transport modeling components include the Environmental Protection Agency, Nuclear Regulatory Commission, Department of Agriculture, Department of Energy, National Science Foundation, Department of Defense, United States Geological Survey, and National Institutes of Health

  2. An overview of bioinformatics methods for modeling biological pathways in yeast.

    Science.gov (United States)

    Hou, Jie; Acharya, Lipi; Zhu, Dongxiao; Cheng, Jianlin

    2016-03-01

    The advent of high-throughput genomics techniques, along with the completion of genome sequencing projects, identification of protein-protein interactions and reconstruction of genome-scale pathways, has accelerated the development of systems biology research in the yeast organism Saccharomyces cerevisiae In particular, discovery of biological pathways in yeast has become an important forefront in systems biology, which aims to understand the interactions among molecules within a cell leading to certain cellular processes in response to a specific environment. While the existing theoretical and experimental approaches enable the investigation of well-known pathways involved in metabolism, gene regulation and signal transduction, bioinformatics methods offer new insights into computational modeling of biological pathways. A wide range of computational approaches has been proposed in the past for reconstructing biological pathways from high-throughput datasets. Here we review selected bioinformatics approaches for modeling biological pathways inS. cerevisiae, including metabolic pathways, gene-regulatory pathways and signaling pathways. We start with reviewing the research on biological pathways followed by discussing key biological databases. In addition, several representative computational approaches for modeling biological pathways in yeast are discussed. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  3. Measurements and modelling of atmospheric pollution over the Paris area: an overview of the ESQUIF Project

    Directory of Open Access Journals (Sweden)

    L. Menut

    Full Text Available The "Étude et Simulation de la QUalité de l'air en Ile de France" (ESQUIF project is the first integrated project dedicated to the study of the processes leading to air pollution events over the Paris area. The project was carried out over two years (summer 1998 to winter 2000 to document all types of meteorological conditions favourable to air quality degradation, and in particular to photo oxydant formation. The goals of ESQUIF are (1 to improve our understanding of the relevant chemical and dynamical processes and, in turn, improve their parametrizations in numerical models, and (2 to improve and validate existing models dedicated to pollution analysis, scenarios and/or forecasting, by establishing a comprehensive and thorough database. We present the rationale of the ESQUIF project and we describe the experimental set-up. We also report on the first experiments which took place during the summer of 1998 involving surface networks, and remote sensing instruments as well as several aircraft. Focusing on three days of August 1998, the relative contributions of long-range transported and locally-produced ozone to the elevated ozone concentrations observed during this period are discussed and chemistry-transport model preliminary results on this period are compared to measurements.

    Key words: Atmospheric composition and structure (pollution – urban and regional; troposphere – composition and chemistry – Meteorology and atmospheric dynamics (mesoscale meteorology

  4. Modeling Flood Insurance Penetration in the European Non-Life Market: An Overview

    Science.gov (United States)

    Mohan, P.; Thomson, M.-K.; Das, A.

    2012-04-01

    Non-life property insurance plays a significant role in assessing and managing economic risk. Understanding the exposure, or property at risk, helps insurers and reinsurers to better categorize and manage their portfolios. However, the nature of the flood peril, in particular adverse selection, has led to a complex system of different insurance covers and policies across Europe owing to its public and private distinctions based on premiums provided as ex ante or ex post, socio-economic characterization and various compensation schemes. To model this significant level of complexity within the European flood insurance market requires not only extensive data research, close understanding of insurance companies and associations as well as historic flood events, but also careful evaluation of the flood hazard in terms of return periods and flood extents, and the economic/ financial background of the geographies involved. This abstract explores different approaches for modeling the flood insurance penetration rates in Europe depending on the information available and complexity involved. For countries which have either a regulated market with mandatory or high penetration rate, as for example found in the UK, France and Switzerland, or indeed countries with negligible insurance cover such as Luxembourg, assumptions about the penetration rates can be made at country level. However, in countries with a private insurance market, the picture becomes inherently more complex. For example in both Austria and Germany, flood insurance is generally restricted, associated with high costs to the insured or not available at all in high risk areas. In order to better manage flood risk, the Austria and German government agencies produced the risk classification systems HORA and ZÜRS, respectively, which categorize risk into four risk zones based on the exceedance probability of a flood occurrence. Except for regions that have preserved mandatory flood inclusion from past policies

  5. An evolutionary cascade model for sauropod dinosaur gigantism--overview, update and tests.

    Directory of Open Access Journals (Sweden)

    P Martin Sander

    Full Text Available Sauropod dinosaurs are a group of herbivorous dinosaurs which exceeded all other terrestrial vertebrates in mean and maximal body size. Sauropod dinosaurs were also the most successful and long-lived herbivorous tetrapod clade, but no abiological factors such as global environmental parameters conducive to their gigantism can be identified. These facts justify major efforts by evolutionary biologists and paleontologists to understand sauropods as living animals and to explain their evolutionary success and uniquely gigantic body size. Contributions to this research program have come from many fields and can be synthesized into a biological evolutionary cascade model of sauropod dinosaur gigantism (sauropod gigantism ECM. This review focuses on the sauropod gigantism ECM, providing an updated version based on the contributions to the PLoS ONE sauropod gigantism collection and on other very recent published evidence. The model consist of five separate evolutionary cascades ("Reproduction", "Feeding", "Head and neck", "Avian-style lung", and "Metabolism". Each cascade starts with observed or inferred basal traits that either may be plesiomorphic or derived at the level of Sauropoda. Each trait confers hypothetical selective advantages which permit the evolution of the next trait. Feedback loops in the ECM consist of selective advantages originating from traits higher in the cascades but affecting lower traits. All cascades end in the trait "Very high body mass". Each cascade is linked to at least one other cascade. Important plesiomorphic traits of sauropod dinosaurs that entered the model were ovipary as well as no mastication of food. Important evolutionary innovations (derived traits were an avian-style respiratory system and an elevated basal metabolic rate. Comparison with other tetrapod lineages identifies factors limiting body size.

  6. An Evolutionary Cascade Model for Sauropod Dinosaur Gigantism - Overview, Update and Tests

    Science.gov (United States)

    Sander, P. Martin

    2013-01-01

    Sauropod dinosaurs are a group of herbivorous dinosaurs which exceeded all other terrestrial vertebrates in mean and maximal body size. Sauropod dinosaurs were also the most successful and long-lived herbivorous tetrapod clade, but no abiological factors such as global environmental parameters conducive to their gigantism can be identified. These facts justify major efforts by evolutionary biologists and paleontologists to understand sauropods as living animals and to explain their evolutionary success and uniquely gigantic body size. Contributions to this research program have come from many fields and can be synthesized into a biological evolutionary cascade model of sauropod dinosaur gigantism (sauropod gigantism ECM). This review focuses on the sauropod gigantism ECM, providing an updated version based on the contributions to the PLoS ONE sauropod gigantism collection and on other very recent published evidence. The model consist of five separate evolutionary cascades (“Reproduction”, “Feeding”, “Head and neck”, “Avian-style lung”, and “Metabolism”). Each cascade starts with observed or inferred basal traits that either may be plesiomorphic or derived at the level of Sauropoda. Each trait confers hypothetical selective advantages which permit the evolution of the next trait. Feedback loops in the ECM consist of selective advantages originating from traits higher in the cascades but affecting lower traits. All cascades end in the trait “Very high body mass”. Each cascade is linked to at least one other cascade. Important plesiomorphic traits of sauropod dinosaurs that entered the model were ovipary as well as no mastication of food. Important evolutionary innovations (derived traits) were an avian-style respiratory system and an elevated basal metabolic rate. Comparison with other tetrapod lineages identifies factors limiting body size. PMID:24205267

  7. An evolutionary cascade model for sauropod dinosaur gigantism--overview, update and tests.

    Science.gov (United States)

    Sander, P Martin

    2013-01-01

    Sauropod dinosaurs are a group of herbivorous dinosaurs which exceeded all other terrestrial vertebrates in mean and maximal body size. Sauropod dinosaurs were also the most successful and long-lived herbivorous tetrapod clade, but no abiological factors such as global environmental parameters conducive to their gigantism can be identified. These facts justify major efforts by evolutionary biologists and paleontologists to understand sauropods as living animals and to explain their evolutionary success and uniquely gigantic body size. Contributions to this research program have come from many fields and can be synthesized into a biological evolutionary cascade model of sauropod dinosaur gigantism (sauropod gigantism ECM). This review focuses on the sauropod gigantism ECM, providing an updated version based on the contributions to the PLoS ONE sauropod gigantism collection and on other very recent published evidence. The model consist of five separate evolutionary cascades ("Reproduction", "Feeding", "Head and neck", "Avian-style lung", and "Metabolism"). Each cascade starts with observed or inferred basal traits that either may be plesiomorphic or derived at the level of Sauropoda. Each trait confers hypothetical selective advantages which permit the evolution of the next trait. Feedback loops in the ECM consist of selective advantages originating from traits higher in the cascades but affecting lower traits. All cascades end in the trait "Very high body mass". Each cascade is linked to at least one other cascade. Important plesiomorphic traits of sauropod dinosaurs that entered the model were ovipary as well as no mastication of food. Important evolutionary innovations (derived traits) were an avian-style respiratory system and an elevated basal metabolic rate. Comparison with other tetrapod lineages identifies factors limiting body size.

  8. Oxidation flow reactors (OFRs): overview of recent field and modeling studies

    Science.gov (United States)

    Jimenez, Jose-Luis; Palm, Brett B.; Peng, Zhe; Hu, Weiwei; Ortega, Amber M.; Li, Rui; Campuzano-Jost, Pedro; Day, Douglas A.; Stark, Harald; Brune, William H.; de Gouw, Joost; Schroder, Jason

    2016-04-01

    Oxidation flow reactors (OFRs) are popular tools for studying SOA formation and aging in both laboratory and field experiments. In an OFR, the concentration of an oxidant (OH, O3, or NO3) can be increased, leading to hours-months of equivalent atmospheric oxidation during the several-minute OFR residence time. Using gas- and particle-phase measurements from several recent field campaigns, we demonstrate SOA formation after oxidation of ambient air in an OFR. Typically, more SOA formation is observed from nighttime air than daytime air. This indicates that the concentration of SOA-forming gases in ambient air is relatively higher at night. Measured ambient VOCs are not able to explain the magnitude of SOA formation in the OFR, suggesting that typically unmeasured S/IVOCs (possibly VOC oxidation products or direct emissions) play a substantial intermediary role in ambient SOA formation. We also present highlights from recent OFR oxidant chemistry modeling studies. HOx, Ox, and photolysis chemistry was modeled for two common OH production methods (utilizing 185+254 nm UV light, or 254 nm only). OH exposure (OHexp) can be estimated within a factor of ~2 using model-derived equations, and can be verified in situ using VOC decay measurements. OHexp is strongly dependent on external OH reactivity, which may cause significant OH suppression in some circumstances (e.g., lab/source studies with high precursor concentrations). UV light photolysis and reaction with oxygen atoms are typically not major reaction pathways. Modeling the fate of condensable low-volatility organic gases (LVOCs) formed in an OFR suggests that LVOC fate is dependent on particle condensational sink. E.g., for the range of particle condensational sink at a remote pine forest, anywhere from 20-80% of produced LVOCs were predicted to condense onto aerosols for an OHexp of ~1 day, with the remainder lost to OFR or sampling line walls. Similar to large chamber wall loss corrections, a correction is needed

  9. Structural equation modeling in pediatric psychology: overview and review of applications.

    Science.gov (United States)

    Nelson, Timothy D; Aylward, Brandon S; Steele, Ric G

    2008-08-01

    To describe the use of structural equation modeling (SEM) in the Journal of Pediatric Psychology (JPP) and to discuss the usefulness of SEM applications in pediatric psychology research. The use of SEM in JPP between 1997 and 2006 was examined and compared to leading journals in clinical psychology, clinical child psychology, and child development. SEM techniques were used in psychology research, although investigations employing these methods are becoming more prevalent. Despite its infrequent use to date, SEM is a potentially useful tool for advancing pediatric psychology research with a number of advantages over traditional statistical methods.

  10. Methodologies Related to Computational models in View of Developing Anti-Alzheimer Drugs: An Overview.

    Science.gov (United States)

    Baheti, Kirtee; Kale, Mayura Ajay

    2018-04-17

    Since last two decades, there has been more focus on the development strategies related to Anti-Alzheimer's drug research. This may be attributed to the fact that most of the Alzheimer's cases are still mostly unknown except for a few cases, where genetic differences have been identified. With the progress of the disease, the symptoms involve intellectual deterioration, memory impairment, abnormal personality and behavioural patterns, confusion, aggression, mood swings, irritability Current therapies available for this disease give only symptomatic relief and do not focus on manipulations of biololecular processes. Nearly all the therapies to treat Alzheimer's disease, target to change the amyloid cascade which is considered to be an important in AD pathogenesis. New drug regimens are not able to keep pace with the ever-increasing understanding about dementia at molecular level. Looking into these aggravated problems, we though to put forth molecular modeling as a drug discovery approach for developing novel drugs to treat Alzheimer disease. The disease is incurable and it gets worst as it advances and finally causes death. Due to this, the design of drugs to treat this disease has become an utmost priority for research. One of the most important emerging technologies applied for this has been Computer-assisted drug design (CADD). It is a research tool that employs large scale computing strategies in an attempt to develop a model receptor site which can be used for designing of an anti-Alzheimer drug. The various models of amyloid-based calcium channels have been computationally optimized. Docking and De novo evolution are used to design the compounds. These are further subjected to absorption, distribution, metabolism, excretion and toxicity (ADMET) studies to finally bring about active compounds that are able to cross BBB. Many novel compounds have been designed which might be promising ones for the treatment of AD. The present review describes the research

  11. Cascade annealing: an overview

    International Nuclear Information System (INIS)

    Doran, D.G.; Schiffgens, J.O.

    1976-04-01

    Concepts and an overview of radiation displacement damage modeling and annealing kinetics are presented. Short-term annealing methodology is described and results of annealing simulations performed on damage cascades generated using the Marlowe and Cascade programs are included. Observations concerning the inconsistencies and inadequacies of current methods are presented along with simulation of high energy cascades and simulation of longer-term annealing

  12. THX Experiment Overview

    Science.gov (United States)

    Wernet, Mark; Wroblewski, Adam; Locke, Randy; Georgiadis, Nick

    2016-01-01

    This presentation provides an overview of experiments conducted at NASA GRC to provide turbulent flow measurements needed for new turbulence model development and validation. The experiments include particle image velocimetry (PIV) and hot-wire measurements of mean flow velocity and temperature fields, as well as fluctuating components.

  13. Computer modelling of the UK wind energy resource: final overview report

    Energy Technology Data Exchange (ETDEWEB)

    Burch, S F; Ravenscroft, F

    1993-12-31

    This report describes the results of a programme of work to estimate the UK wind energy resource. Mean wind speed maps and quantitative resource estimates were obtained using the NOABL mesoscale (1 km resolution) numerical model for the prediction of wind flow over complex terrain. NOABL was used in conjunction with digitised terrain data and wind data from surface meteorological stations for a ten year period (1975-1984) to provide digital UK maps of mean wind speed at 10m, 25m and 45m above ground level. Also included in the derivation of these maps was the use of the Engineering Science Data Unit (ESDU) method to model the effect on wind speed of the abrupt change in surface roughness that occurs at the coast. Existing isovent maps, based on standard meteorological data which take no account of terrain effects, indicate that 10m annual mean wind speeds vary between about 4.5 and 7 m/s over the UK with only a few coastal areas over 6 m/s. The present study indicated that 23% of the UK land area had speeds over 6 m/s, with many hill sites having 10m speeds over 10 m/s. It is concluded that these `first order` resource estimates represent a substantial improvement over the presently available `zero order` estimates. (20 figures, 7 tables, 10 references). (author)

  14. Overview of Battelle-Europe experiments and model development on H2-deflagrations, igniter and catalytic device verifications

    International Nuclear Information System (INIS)

    Wolf, L.; Kanzleiter, T.; Behrens, U.; Langer, G.; Fischer, K.; Holzbauer, H.; Seidler, M.; Wolff, U.

    1991-01-01

    The design and implementation of an optimal mitigation strategy against the potential threat by H 2 -deflagrations/detonations in the aftermath of least probable severe accidents necessitates a knowledge base about these phenomena for representative conditions and realistic geometries. In order to extend existing know-how into the area of multi-compartment geometries connected by vents, the German Ministry of Research and Technology (BMFT) initiated in 1987 and fully sponsored since 1988 a multi-faceted experimental research program on H 2 -deflagrations and related issues in multi-compartment geometries in the Battelle Model Containment (BMC). The following test groups constitute the Battelle-program: Test Group H: basic tests in H 2 -air and H 2 -steam air-mixtures; Test Group I: (sponsored by industry): supplemental tests in H 2 -air and H 2 -steam-air atmospheres; Test Group G: efficiency of H 2 -mitigative measures such as igniters, catalyst modules and combinations thereof. Thus far, a total of 70 experiments have been performed and evaluated. The paper gives an overview of the Battelle-program by reviewing the examined geometries, bandwidths of tested H 2 -concentrations, steam concentrations, ignition locations, specific atmospheric conditions (homogeneous, stratified) and other important parameters varied during and among the different test groups H, G, and I. Some experimental findings are reported

  15. Computational Approaches to Modeling Artificial Emotion -– An overview of the Proposed Solutions

    Directory of Open Access Journals (Sweden)

    Zdzislaw eKOWALCZUK

    2016-04-01

    Full Text Available Cybernetic approach to modeling artificial emotion through the use of different theories of psychology is considered in this paper, presenting a review of twelve proposed solutions: ActAffAct, FLAME, EMA, ParleE, FearNot!, FAtiMA, WASABI, Cathexis, KARO, MAMID, FCM, and xEmotion. The main motivation for this study is founded on the hypothesis that emotions can play a definite utility role of scheduling variables in the construction of intelligent autonomous systems, agents and mobile robots. In this review we also include an innovative and panoptical, comprehensive system, referred to as the Intelligent System of Decision-making (ISD, which has been employed in practical applications of various autonomous units, and which applies as its part the xEmotion, taking into consideration the personal aspects of emotions, affects (short term emotions and mood (principally, long term emotions.

  16. Overview of the development of a biosphere modelling capability for UK DoE (HMIP)

    International Nuclear Information System (INIS)

    Nancarrow, D.J.; Ashton, J.; Little, R.H.

    1990-01-01

    A programme of research has been funded, since 1982, by the United Kingdom Department of the Environment (Her Majesty's Inspectorate of Pollution, HMIP), to develop a procedure for post-closure radiological assessment of underground disposal facilities for low and intermediate level radioactive wastes. It is conventional to regard the disposal system as comprising the engineered barriers of the repository, the geological setting which provides natural barriers to migration, and the surface environment or biosphere. The requirement of a biosphere submodel, therefore, is to provide estimates, for given radionuclide inputs, of the dose or probability distribution function of dose to a maximally exposed individual as a function of time. This paper describes the development of the capability for biosphere modelling for HMIP in the context of the development of other assessment procedures. 11 refs., 3 figs., 2 tabs

  17. A Conceptual Model of Agile Software Development in a Safety-Critical Context: A Systematic Literature Review

    DEFF Research Database (Denmark)

    Tordrup Heeager, Lise; Nielsen, Peter Axel

    2018-01-01

    challenges of agile software development of safety-critical systems. The conceptual model consists of four problematic practice areas and five relationships, which we find to be even more important than the problematic areas. From this review, we suggest that there are important research gaps that need...... processes or agile processes that are purportedly faster and promise to lead to better products. Objective: To identify the issues and disputes in agile development of safety-critical software and the key qualities as found in the extant research literature. Method: We conducted a systematic literature...... review as an interpretive study following a research design to search, assess, extract, group, and understand the results of the found studies. Results: There are key issues and propositions that we elicit from the literature and combine into a conceptual model for understanding the foundational...

  18. Transferring knowledge from observations and models to decision makers: an overview and challenges

    Science.gov (United States)

    Habib, Shahid; Nokra, Nada A.

    2004-02-01

    Over the last 25 years, a tremendous progress has been made in the Earth science space-based remote sensing observations, technologies and algorithms. Such advancements have improved the predictability by providing lead-time and accuracy of forecast in weather, climate, natural hazards, and natural resources. It has further reduced or bounded the overall uncertainties by partially improving our understanding of planet Earth as an integrated system that is governed by non-linear and chaotic behavior. Many countries such US, European Community, Japan, China and others have invested billions of dollars in developing and launching space-based assets in the low earth (LEO) and geostationary (GEO) orbits. However, the wealth of this scientific knowledge that has potential of extracting monumental socio-economic benefits from such large investments have been slow in reaching the public and decision makers. For instance, there are a number of areas such as energy forecasting, aviation safety, agricultural competitiveness, disaster management, homeland security, air quality and public health, which can directly take advantage. Nevertheless, we all live in a global economy that depends on access to the best available Earth Science information for all inhabitants of this planet. This paper surveys and examines a number such applications in terms of their architecture, maturity and economic applicability as they apply to the societal needs. A detailed analysis is also presented of various challenges and issues that pertain to a number of areas such as: (1) difficulties in making a speedy transition of data and information from observations and models to relevant Decision Support Systems (DSS) or tools, (2) data and models inter-operability issues, (3) limitations of spatial, spectral and temporal resolution,(4) communication limitations as dictated by the availability of image processing and data compression techniques. Additionally, the most critical element amongst all is

  19. Transferring Knowledge from Observations and Models to Decision Makers: An Overview and Challenges

    Science.gov (United States)

    Habib, Shahid; Nokra, Nada Abu

    2003-01-01

    Over the last 25 years, a tremendous progress has been made in the Earth science space-based remote sensing observations, technologies and algorithms. Such advancements have improved the predictability by providing lead-time and accuracy of forecast in weather, climate, natural hazards, and natural resources. It has further reduced or bounded the overall uncertainties by partially improving our understanding of planet Earth as an integrated system that is governed by non-linear and chaotic behavior. Many countries such US, European Community, Japan, China and others have invested billions of dollars in developing and launching space-based assets in the low earth (LEO) and geostationary (GEO) orbits. However, the wealth of this scientific knowledge that has potential of extracting monumental socio-economic benefits from such large investments have been slow in reaching to public and decision makers. For instance, there are a number of areas such as energy forecasting, aviation safety, agricultural competitiveness, disaster management, security, air quality and public health can directly take advantage. Nevertheless, we all live in a global economy that depends on access to the best available Earth Science information for all inhabitants of this planet. This paper surveys and examines a number such applications in terms of their architecture, maturity and economic applicability as they apply to the societal needs. A detailed analysis is also presented of various challenges and issues that pertain to a number of areas such as: (1) difficulties in making a speedy transition of data and information from observations and models to relevant Decision Support Systems (DSS) or tools, (2) data and models inter-operability issues, (3) limitations of spatial, spectral and temporal resolution, (4) communication limitations as dictated by the availability of image processing and data compression techniques. Additionally, the most critical element amongst all is the organizational

  20. Large-Scale Atmospheric Circulation Patterns Associated with Temperature Extremes as a Basis for Model Evaluation: Methodological Overview and Results

    Science.gov (United States)

    Loikith, P. C.; Broccoli, A. J.; Waliser, D. E.; Lintner, B. R.; Neelin, J. D.

    2015-12-01

    Anomalous large-scale circulation patterns often play a key role in the occurrence of temperature extremes. For example, large-scale circulation can drive horizontal temperature advection or influence local processes that lead to extreme temperatures, such as by inhibiting moderating sea breezes, promoting downslope adiabatic warming, and affecting the development of cloud cover. Additionally, large-scale circulation can influence the shape of temperature distribution tails, with important implications for the magnitude of future changes in extremes. As a result of the prominent role these patterns play in the occurrence and character of extremes, the way in which temperature extremes change in the future will be highly influenced by if and how these patterns change. It is therefore critical to identify and understand the key patterns associated with extremes at local to regional scales in the current climate and to use this foundation as a target for climate model validation. This presentation provides an overview of recent and ongoing work aimed at developing and applying novel approaches to identifying and describing the large-scale circulation patterns associated with temperature extremes in observations and using this foundation to evaluate state-of-the-art global and regional climate models. Emphasis is given to anomalies in sea level pressure and 500 hPa geopotential height over North America using several methods to identify circulation patterns, including self-organizing maps and composite analysis. Overall, evaluation results suggest that models are able to reproduce observed patterns associated with temperature extremes with reasonable fidelity in many cases. Model skill is often highest when and where synoptic-scale processes are the dominant mechanisms for extremes, and lower where sub-grid scale processes (such as those related to topography) are important. Where model skill in reproducing these patterns is high, it can be inferred that extremes are

  1. An overview of challenges in modeling heat and mass transfer for living on Mars.

    Science.gov (United States)

    Yamashita, Masamichi; Ishikawa, Yoji; Kitaya, Yoshiaki; Goto, Eiji; Arai, Mayumi; Hashimoto, Hirofumi; Tomita-Yokotani, Kaori; Hirafuji, Masayuki; Omori, Katsunori; Shiraishi, Atsushi; Tani, Akira; Toki, Kyoichiro; Yokota, Hiroki; Fujita, Osamu

    2006-09-01

    Engineering a life-support system for living on Mars requires the modeling of heat and mass transfer. This report describes the analysis of heat and mass transfer phenomena in a greenhouse dome, which is being designed as a pressurized life-support system for agricultural production on Mars. In this Martian greenhouse, solar energy will be converted into chemical energy in plant biomass. Agricultural products will be harvested for food and plant cultivation, and waste materials will be processed in a composting microbial ecosystem. Transpired water from plants will be condensed and recycled. In our thermal design and analysis for the Martian greenhouse, we addressed the question of whether temperature and pressure would be maintained in the appropriate range for humans as well as plants. Energy flow and material circulation should be controlled to provide an artificial ecological system on Mars. In our analysis, we assumed that the greenhouse would be maintained at a subatmospheric pressure under 1/3-G gravitational force with 1/2 solar light intensity on Earth. Convection of atmospheric gases will be induced inside the greenhouse, primarily by heating from sunlight. Microclimate (thermal and gas species structure) could be generated locally around plant bodies, which would affect gas transport. Potential effects of those environmental factors are discussed on the phenomena including plant growth and plant physiology and focusing on transport processes. Fire safety is a crucial issue and we evaluate its impact on the total gas pressure in the greenhouse dome.

  2. An overview of the Yucca Mountain Global/Regional Climate Modeling Program

    International Nuclear Information System (INIS)

    Sandoval, R.P.; Behl, Y.K.; Thompson, S.L.

    1992-01-01

    The US Department of Energy (DOE) has developed a site characterization plan (SCP) to collect detailed information on geology, geohydrology, geochemistry, geoengineering, hydrology, climate, and meteorology (collectively referred to as ''geologic information'') of the Yucca Mountain site. This information will be used to determine if a mined geologic disposal system (MGDS) capable of isolating high-level radioactive waste without adverse effects to public health and safety over 10,000 years, as required by regulations 40 CFR Part 191 and 10 CFR Part 60, could be constructed at the Yucca Mountain site. Forecasts of future climates conditions for the Yucca Mountain area will be based on both empirical and numerical techniques. The empirical modeling is based on the assumption that future climate change will follow past patterns. In this approach, paleclimate records will be analyzed to estimate the nature, timing, and probability of occurrence of certain climate states such as glacials and interglacials over the next 10,000 years. For a given state, key climate parameters such as precipitation and temperature will be assumed to be the same as determined from the paleoclimate data. The numerical approach, which is the primary focus of this paper, involves the numerical solution of basic equations associated with atmospheric motions. This paper describes these equations and the strategy for solving them to predict future climate conditions around Yucca Mountain

  3. Gamma Ray Large Area Space Telescope (GLAST) Balloon Flight Engineering Model: Overview

    Science.gov (United States)

    Thompson, D. J.; Godfrey, G.; Williams, S. M.; Grove, J. E.; Mizuno, T.; Sadrozinski, H. F.-W.; Kamae, T.; Ampe, J.; Briber, Stuart; Dann, James; hide

    2001-01-01

    The Gamma Ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT) is a pair-production high-energy (greater than 20 MeV) gamma-ray telescope being built by an international partnership of astrophysicists and particle physicists for a satellite launch in 2006, designed to study a wide variety of high-energy astrophysical phenomena. As part of the development effort, the collaboration has built a Balloon Flight Engineering Model (BFEM) for flight on a high-altitude scientific balloon. The BFEM is approximately the size of one of the 16 GLAST-LAT towers and contains all the components of the full instrument: plastic scintillator anticoincidence system (ACD), high-Z foil/Si strip pair-conversion tracker (TKR), CsI hodoscopic calorimeter (CAL), triggering and data acquisition electronics (DAQ), commanding system, power distribution, telemetry, real-time data display, and ground data processing system. The principal goal of the balloon flight was to demonstrate the performance of this instrument configuration under conditions similar to those expected in orbit. Results from a balloon flight from Palestine, Texas, on August 4, 2001, show that the BFEM successfully obtained gamma-ray data in this high-background environment.

  4. Statistical methods applied to the study of opinion formation models: a brief overview and results of a numerical study of a model based on the social impact theory

    Science.gov (United States)

    Bordogna, Clelia María; Albano, Ezequiel V.

    2007-02-01

    The aim of this paper is twofold. On the one hand we present a brief overview on the application of statistical physics methods to the modelling of social phenomena focusing our attention on models for opinion formation. On the other hand, we discuss and present original results of a model for opinion formation based on the social impact theory developed by Latané. The presented model accounts for the interaction among the members of a social group under the competitive influence of a strong leader and the mass media, both supporting two different states of opinion. Extensive simulations of the model are presented, showing that they led to the observation of a rich scenery of complex behaviour including, among others, critical behaviour and phase transitions between a state of opinion dominated by the leader and another dominated by the mass media. The occurrence of interesting finite-size effects reveals that, in small communities, the opinion of the leader may prevail over that of the mass media. This observation is relevant for the understanding of social phenomena involving a finite number of individuals, in contrast to actual physical phase transitions that take place in the thermodynamic limit. Finally, we give a brief outlook of open questions and lines for future work.

  5. Statistical methods applied to the study of opinion formation models: a brief overview and results of a numerical study of a model based on the social impact theory

    International Nuclear Information System (INIS)

    Bordogna, Clelia Maria; Albano, Ezequiel V

    2007-01-01

    The aim of this paper is twofold. On the one hand we present a brief overview on the application of statistical physics methods to the modelling of social phenomena focusing our attention on models for opinion formation. On the other hand, we discuss and present original results of a model for opinion formation based on the social impact theory developed by Latane. The presented model accounts for the interaction among the members of a social group under the competitive influence of a strong leader and the mass media, both supporting two different states of opinion. Extensive simulations of the model are presented, showing that they led to the observation of a rich scenery of complex behaviour including, among others, critical behaviour and phase transitions between a state of opinion dominated by the leader and another dominated by the mass media. The occurrence of interesting finite-size effects reveals that, in small communities, the opinion of the leader may prevail over that of the mass media. This observation is relevant for the understanding of social phenomena involving a finite number of individuals, in contrast to actual physical phase transitions that take place in the thermodynamic limit. Finally, we give a brief outlook of open questions and lines for future work

  6. Performance improvement based on integrated quality management models: What evidence do we have? A systematic literature review

    NARCIS (Netherlands)

    M.M.N. Minkman (Mirella); C.T.B. Ahaus (Kees); R. Huijsman (Robbert)

    2007-01-01

    textabstractPurpose. Health care organizations have to improve their performance for multiple stakeholders and organize integrated care. To facilitate this, various integrated quality management models can be used. This article reviews the literature on the Malcolm Baldrige Quality Award (MBQA)

  7. Performance improvement based on integrated quality management models : What evidence do we have? A systematic literature review

    NARCIS (Netherlands)

    Minkman, Mirella; Ahaus, Kees; Huijsman, Robbert

    Purpose. Health care organizations have to improve their performance for multiple stakeholders and organize integrated care. To facilitate this, various integrated quality management models can be used. This article reviews the literature on the Malcolm Baldrige Quality Award (MBQA) criteria, the

  8. Faculty Perceptions about Teaching Online: Exploring the Literature Using the Technology Acceptance Model as an Organizing Framework

    Science.gov (United States)

    Wingo, Nancy Pope; Ivankova, Nataliya V.; Moss, Jacqueline A.

    2017-01-01

    Academic leaders can better implement institutional strategic plans to promote online programs if they understand faculty perceptions about teaching online. An extended version of a model for technology acceptance, or TAM2 (Venkatesh & Davis, 2000), provided a framework for surveying and organizing the research literature about factors that…

  9. Composite quality of care scores, electronic health record maturity models, and their associations; preliminary literature review results

    NARCIS (Netherlands)

    Joukes, Erik; de Keizer, Nicolette; Cornet, Ronald

    2013-01-01

    To accurately assess the association between the use of EHR systems and the quality of healthcare we need (composite) measures for quality of healthcare, and a model to measure the maturity of the EHR. This Medline-based literature study therefore focussed on three topics; (1) methods to compose a

  10. An overview of current applications, challenges, and future trends in distributed process-based models in hydrology

    Science.gov (United States)

    Fatichi, Simone; Vivoni, Enrique R.; Odgen, Fred L; Ivanov, Valeriy Y; Mirus, Benjamin B.; Gochis, David; Downer, Charles W; Camporese, Matteo; Davison, Jason H; Ebel, Brian A.; Jones, Norm; Kim, Jongho; Mascaro, Giuseppe; Niswonger, Richard G.; Restrepo, Pedro; Rigon, Riccardo; Shen, Chaopeng; Sulis, Mauro; Tarboton, David

    2016-01-01

    Process-based hydrological models have a long history dating back to the 1960s. Criticized by some as over-parameterized, overly complex, and difficult to use, a more nuanced view is that these tools are necessary in many situations and, in a certain class of problems, they are the most appropriate type of hydrological model. This is especially the case in situations where knowledge of flow paths or distributed state variables and/or preservation of physical constraints is important. Examples of this include: spatiotemporal variability of soil moisture, groundwater flow and runoff generation, sediment and contaminant transport, or when feedbacks among various Earth’s system processes or understanding the impacts of climate non-stationarity are of primary concern. These are situations where process-based models excel and other models are unverifiable. This article presents this pragmatic view in the context of existing literature to justify the approach where applicable and necessary. We review how improvements in data availability, computational resources and algorithms have made detailed hydrological simulations a reality. Avenues for the future of process-based hydrological models are presented suggesting their use as virtual laboratories, for design purposes, and with a powerful treatment of uncertainty.

  11. An overview of current applications, challenges, and future trends in distributed process-based models in hydrology

    Science.gov (United States)

    Fatichi, Simone; Vivoni, Enrique R.; Ogden, Fred L.; Ivanov, Valeriy Y.; Mirus, Benjamin; Gochis, David; Downer, Charles W.; Camporese, Matteo; Davison, Jason H.; Ebel, Brian; Jones, Norm; Kim, Jongho; Mascaro, Giuseppe; Niswonger, Richard; Restrepo, Pedro; Rigon, Riccardo; Shen, Chaopeng; Sulis, Mauro; Tarboton, David

    2016-06-01

    Process-based hydrological models have a long history dating back to the 1960s. Criticized by some as over-parameterized, overly complex, and difficult to use, a more nuanced view is that these tools are necessary in many situations and, in a certain class of problems, they are the most appropriate type of hydrological model. This is especially the case in situations where knowledge of flow paths or distributed state variables and/or preservation of physical constraints is important. Examples of this include: spatiotemporal variability of soil moisture, groundwater flow and runoff generation, sediment and contaminant transport, or when feedbacks among various Earth's system processes or understanding the impacts of climate non-stationarity are of primary concern. These are situations where process-based models excel and other models are unverifiable. This article presents this pragmatic view in the context of existing literature to justify the approach where applicable and necessary. We review how improvements in data availability, computational resources and algorithms have made detailed hydrological simulations a reality. Avenues for the future of process-based hydrological models are presented suggesting their use as virtual laboratories, for design purposes, and with a powerful treatment of uncertainty.

  12. An overview of the gene regulatory network controlling trichome development in the model plant, Arabidopsis

    Directory of Open Access Journals (Sweden)

    Sitakanta ePattanaik

    2014-06-01

    Full Text Available Trichomes are specialized epidermal cells located on aerial parts of plants and are associated with a wide array of biological processes. Trichomes protect plants from adverse conditions including UV light and herbivore attack and are also an important source of a number of phytochemicals. The simple unicellular trichomes of Arabidopsis serve as an excellent model to study molecular mechanism of cell differentiation and pattern formation in plants. The emerging picture suggests that the developmental process is controlled by a transcriptional network involving three major groups of transcription factors: the R2R3 MYB, basic helix-loop-helix (bHLH and WD40 repeat (WDR protein. These regulatory proteins form a trimeric activator complex that positively regulates trichome development. The single repeat R3 MYBs act as negative regulators of trichome development. They compete with the R2R3 MYBs to bind the bHLH factor and form a repressor complex. In addition to activator-repressor mechanism, a depletion mechanism may operate in parallel during trichome development. In this mechanism, the bHLH factor traps the WDR protein which results in depletion of WDR protein in neighboring cells. Consequently, the cells with high levels of bHLH and WDR proteins are developed into trichomes. A group of C2H2 zinc finger TFs has also been implicated in trichome development. Phytohormones, including gibberellins and jasmonic acid, play significant roles in this developmental process. Recently, microRNAs have been shown to be involved in trichome development. Furthermore, it has been demonstrated that the activities of the key regulatory proteins involved in trichome development are controlled by the 26S/ubiquitin proteasome system (UPS, highlighting the complexity of the regulatory network controlling this developmental process. To complement several excellent recent relevant reviews, this review focuses on the transcriptional network and hormonal interplay

  13. Infection prevention behaviour and infectious disease modelling: a review of the literature and recommendations for the future.

    Science.gov (United States)

    Weston, Dale; Hauck, Katharina; Amlôt, Richard

    2018-03-09

    Given the importance of person to person transmission in the spread of infectious diseases, it is critically important to ensure that human behaviour with respect to infection prevention is appropriately represented within infectious disease models. This paper presents a large scale scoping review regarding the incorporation of infection prevention behaviour in infectious disease models. The outcomes of this review are contextualised within the psychological literature concerning health behaviour and behaviour change, resulting in a series of key recommendations for the incorporation of human behaviour in future infectious disease models. The search strategy focused on terms relating to behaviour, infectious disease and mathematical modelling. The selection criteria were developed iteratively to focus on original research articles that present an infectious disease model with human-human spread, in which individuals' self-protective health behaviour varied endogenously within the model. Data extracted included: the behaviour that is modelled; how this behaviour is modelled; any theoretical background for the modelling of behaviour, and; any behavioural data used to parameterise the models. Forty-two papers from an initial total of 2987 were retained for inclusion in the final review. All of these papers were published between 2002 and 2015. Many of the included papers employed a multiple, linked models to incorporate infection prevention behaviour. Both cognitive constructs (e.g., perceived risk) and, to a lesser extent, social constructs (e.g., social norms) were identified in the included papers. However, only five papers made explicit reference to psychological health behaviour change theories. Finally, just under half of the included papers incorporated behavioural data in their modelling. By contextualising the review outcomes within the psychological literature on health behaviour and behaviour change, three key recommendations for future behavioural

  14. Development of new geoinformation methods for modelling and prediction of sea level change over different timescales - overview of the project

    Science.gov (United States)

    Niedzielski, T.; Włosińska, M.; Miziński, B.; Hewelt, M.; Migoń, P.; Kosek, W.; Priede, I. G.

    2012-04-01

    The poster aims to provide a broad scientific audience with a general overview of a project on sea level change modelling and prediction that has just commenced at the University of Wrocław, Poland. The initiative that the project fits, called the Homing Plus programme, is organised by the Foundation for Polish Science and financially supported by the European Union through the European Regional Development Fund and the Innovative Economy Programme. There are two key research objectives of the project that complement each other. First, emphasis is put on modern satellite altimetric gridded time series from the Archiving, Validation and Interpretation of Satellite Oceanographic data (AVISO) repository. Daily sea level anomaly maps, access to which in near-real time is courtesy of AVISO, are being steadily downloaded every day to our local server in Wroclaw, Poland. These data will be processed within a general framework of modelling and prediction of sea level change in short, medium and long term. Secondly, sea level change over geological time is scrutinised in order to cover very long time scales that go far beyond a history of altimetric and tide-gauge measurements. The aforementioned approaches comprise a few tasks that aim to solve the following detailed problems. Within the first one, our objective is to seek spatio-temporal dependencies in the gridded sea level anomaly time series. Subsequently, predictions that make use of such cross-correlations shall be derived, and near-real time service for automatic update with validation will be implemented. Concurrently, (i.e. apart from spatio-temporal dependencies and their use in the process of forecasting variable sea level topography), threshold models shall be utilised for predicting the El Niño/Southern Oscillation (ENSO) signal that is normally present in sea level anomaly time series of the equatorial Pacific. Within the second approach, however, the entirely different methods are proposed. Links between

  15. Recent Literature on Government Information

    Science.gov (United States)

    Sleeman, Bill

    2004-01-01

    The purpose of this column is to provide government information scholars and students with a broad overview of recent publications about government information from the literature of librarianship, archives, information technology management, public policy and law. Given the volume of literature produced in this field, a columnist cannot claim…

  16. LitPathExplorer: a confidence-based visual text analytics tool for exploring literature-enriched pathway models.

    Science.gov (United States)

    Soto, Axel J; Zerva, Chrysoula; Batista-Navarro, Riza; Ananiadou, Sophia

    2018-04-15

    Pathway models are valuable resources that help us understand the various mechanisms underpinning complex biological processes. Their curation is typically carried out through manual inspection of published scientific literature to find information relevant to a model, which is a laborious and knowledge-intensive task. Furthermore, models curated manually cannot be easily updated and maintained with new evidence extracted from the literature without automated support. We have developed LitPathExplorer, a visual text analytics tool that integrates advanced text mining, semi-supervised learning and interactive visualization, to facilitate the exploration and analysis of pathway models using statements (i.e. events) extracted automatically from the literature and organized according to levels of confidence. LitPathExplorer supports pathway modellers and curators alike by: (i) extracting events from the literature that corroborate existing models with evidence; (ii) discovering new events which can update models; and (iii) providing a confidence value for each event that is automatically computed based on linguistic features and article metadata. Our evaluation of event extraction showed a precision of 89% and a recall of 71%. Evaluation of our confidence measure, when used for ranking sampled events, showed an average precision ranging between 61 and 73%, which can be improved to 95% when the user is involved in the semi-supervised learning process. Qualitative evaluation using pair analytics based on the feedback of three domain experts confirmed the utility of our tool within the context of pathway model exploration. LitPathExplorer is available at http://nactem.ac.uk/LitPathExplorer_BI/. sophia.ananiadou@manchester.ac.uk. Supplementary data are available at Bioinformatics online.

  17. Using literature and data to learn Bayesian networks as clinical models of ovarian tumors

    DEFF Research Database (Denmark)

    Antal, P.; Fannes, G.; Timmerman, D.

    2004-01-01

    Thanks to its increasing availability, electronic literature has become a potential source of information for the development of complex Bayesian networks (BN), when human expertise is missing or data is scarce or contains much noise. This opportunity raises the question of how to integrate...... information from free-text resources with statistical data in learning Bayesian networks. Firstly, we report on the collection of prior information resources in the ovarian cancer domain, which includes "kernel" annotations of the domain variables. We introduce methods based on the annotations and literature...

  18. An Overview of the Future Development of Climate and Earth System Models for Scientific and Policy Use (Invited)

    Science.gov (United States)

    Washington, W. M.

    2010-12-01

    The development of climate and earth system models has been regarded primarily as the making of scientific tools to study the complex nature of the Earth’s climate. These models have a long history starting with very simple physical models based on fundamental physics in the 1960s and over time they have become much more complex with atmospheric, ocean, sea ice, land/vegetation, biogeochemical, glacial and ecological components. The policy use aspects of these models did not start in the 1960s and 1970s as decision making tools but were used to answer fundamental scientific questions such as what happens when the atmospheric carbon dioxide concentration increases or is doubled. They gave insights into the various interactions and were extensively compared with observations. It was realized that models of the earlier time periods could only give first order answers to many of the fundamental policy questions. As societal concerns about climate change rose, the policy questions of anthropogenic climate change became better defined; they were mostly concerned with the climate impacts of increasing greenhouse gases, aerosols, and land cover change. In the late 1980s, the United Nations set up the Intergovernmental Panel on Climate Change to perform assessments of the published literature. Thus, the development of climate and Earth system models became intimately linked to the need to not only improve our scientific understanding but also answering fundamental policy questions. In order to meet this challenge, the models became more complex and realistic so that they could address these policy oriented science questions such as rising sea level. The presentation will discuss the past and future development of global climate and earth system models for science and policy purposes. Also to be discussed is their interactions with economic integrated assessment models, regional and specialized models such as river transport or ecological components. As an example of one

  19. PHOBOS Overview

    Science.gov (United States)

    Hofman, David J.; Phobos Collaboration; Bbback; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Budzanowski, A.; Busza, W.; Carroll, A.; Chai, Z.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Hauer, M.; Heintzelman, G. A.; Henderson, C.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Lin, W. T.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I. C.; Reed, C.; Roland, C.; Roland, G.; Sagerer, J.; Seals, H.; Sedykh, I.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Wenger, E.; Wolfs, F. L. H.; Wosiek, B.; Kwoźniak; Wysłouch, B.

    2006-11-01

    A brief overview of the current results and conclusions from the PHOBOS experiment at the Relativistic Heavy Ion Collider (RHIC) is given. No evidence is found for non-monotonic behavior of observables measured by PHOBOS in the RHIC energy region. Convincing evidence is found that we have created a state of matter with high energy-density, that is nearly net-baryon free and is strongly interacting. The data are found to exhibit "simple" scaling behaviors, which include extended longitudinal scaling and scaling with the number of participating nucleons. The Au+Au collision charged particle data also exhibit a remarkable factorization of collision energy and geometry.

  20. An Overview of Modeling Approaches Applied to Aggregation-Based Fleet Management and Integration of Plug-in Electric Vehicles †

    Directory of Open Access Journals (Sweden)

    Shi You

    2016-11-01

    Full Text Available The design and implementation of management policies for plug-in electric vehicles (PEVs need to be supported by a holistic understanding of the functional processes, their complex interactions, and their response to various changes. Models developed to represent different functional processes and systems are seen as useful tools to support the related studies for different stakeholders in a tangible way. This paper presents an overview of modeling approaches applied to support aggregation-based management and integration of PEVs from the perspective of fleet operators and grid operators, respectively. We start by explaining a structured modeling approach, i.e., a flexible combination of process models and system models, applied to different management and integration studies. A state-of-the-art overview of modeling approaches applied to represent several key processes, such as charging management, and key systems, such as the PEV fleet, is then presented, along with a detailed description of different approaches. Finally, we discuss several considerations that need to be well understood during the modeling process in order to assist modelers and model users in the appropriate decisions of using existing, or developing their own, solutions for further applications.

  1. Air quality and climate change, Topic 3 of the Model Inter-Comparison Study for Asia Phase III (MICS-Asia III) - Part 1: Overview and model evaluation

    Science.gov (United States)

    Gao, Meng; Han, Zhiwei; Liu, Zirui; Li, Meng; Xin, Jinyuan; Tao, Zhining; Li, Jiawei; Kang, Jeong-Eon; Huang, Kan; Dong, Xinyi; Zhuang, Bingliang; Li, Shu; Ge, Baozhu; Wu, Qizhong; Cheng, Yafang; Wang, Yuesi; Lee, Hyo-Jung; Kim, Cheol-Hee; Fu, Joshua S.; Wang, Tijian; Chin, Mian; Woo, Jung-Hun; Zhang, Qiang; Wang, Zifa; Carmichael, Gregory R.

    2018-04-01

    Topic 3 of the Model Inter-Comparison Study for Asia (MICS-Asia) Phase III examines how online coupled air quality models perform in simulating high aerosol pollution in the North China Plain region during wintertime haze events and evaluates the importance of aerosol radiative and microphysical feedbacks. A comprehensive overview of the MICS-Asia III Topic 3 study design, including descriptions of participating models and model inputs, the experimental designs, and results of model evaluation, are presented. Six modeling groups from China, Korea and the United States submitted results from seven applications of online coupled chemistry-meteorology models. Results are compared to meteorology and air quality measurements, including data from the Campaign on Atmospheric Aerosol Research Network of China (CARE-China) and the Acid Deposition Monitoring Network in East Asia (EANET). The correlation coefficients between the multi-model ensemble mean and the CARE-China observed near-surface air pollutants range from 0.51 to 0.94 (0.51 for ozone and 0.94 for PM2.5) for January 2010. However, large discrepancies exist between simulated aerosol chemical compositions from different models. The coefficient of variation (SD divided by the mean) can reach above 1.3 for sulfate in Beijing and above 1.6 for nitrate and organic aerosols in coastal regions, indicating that these compositions are less consistent from different models. During clean periods, simulated aerosol optical depths (AODs) from different models are similar, but peak values differ during severe haze events, which can be explained by the differences in simulated inorganic aerosol concentrations and the hygroscopic growth efficiency (affected by varied relative humidity). These differences in composition and AOD suggest that future models can be improved by including new heterogeneous or aqueous pathways for sulfate and nitrate formation under hazy conditions, a secondary organic aerosol (SOA) formation chemical

  2. Literature mining supports a next-generation modeling approach to predict cellular byproduct secretion

    DEFF Research Database (Denmark)

    King, Zachary A.; O'Brien, Edward J.; Feist, Adam M.

    2017-01-01

    metabolic byproduct secretion with bottom-up reconstructions of metabolic networks. However, owing to a lack of data, it has not been possible to validate these predictions across a wide range of strains and conditions. Through literature mining, we were able to generate a database of Escherichia coli...

  3. Towards a Transnational Model of Critical Values Education: The Case for Literature Education in Singapore

    Science.gov (United States)

    Choo, Suzanne S.

    2015-01-01

    Once regarded as the most essential subject in the national curriculum vital for civilizing the public, English Literature has now lost its place of prominence. In this paper, I focus on Singapore where the subject was a core aspect of the colonial curriculum and where it is currently facing declining enrolment at the national examinations. In the…

  4. Towards a Research Model for Distance Education-Contributions from the Telecommuting Literature.

    Science.gov (United States)

    Dick, Geoffrey N.

    This paper draws on an extensive review of literature associated with telecommuting and looks at features that might affect the offering and take-up of distance education, particularly distance education involving computer applications, telecommunications and web-based, off-campus delivery of courses or components of courses. The issue is…

  5. Quantification of health effects of breastfeeding - Review of the literature and model simulation

    NARCIS (Netherlands)

    Rossum CTM van; Buchner FL; Hoekstra J; CVG

    2006-01-01

    Breastfeeding has positive health effects, with the largest health gain realized through policy that focuses on encouraging all mothers to start breastfeeding. A literature review shows that breastfeeding has beneficial health effects in both the short and the longer term. There is convincing

  6. Experimental overview

    International Nuclear Information System (INIS)

    Nagamiya, Shoji

    1992-01-01

    Five years ago the first heavy-ion beams were accelerated at both the BNL-AGS and the CERN-SPS. This conference is the 5th anniversary in the experimental field. Currently, four experimental groups (E802/E859, E810, E814, E858) are taking data at BNL and eight groups (NA34-3, NA44, NA45, NA35, NA36, NA38, WA80/WA93, WA85) at CERN. Au and Pb beams are about to come, and a lot of activities are going on for RHIC and LHC. The purpose of this talk is to overview where we are, in particular, by looking at the past data. In this talk, the data of proton rapidity distributions are reviewed first to study nuclear transparency, then, the data of energy spectra and slopes, HBT and anti d production are discussed in connection with the evolution of the collision. Third, the data of strangeness production are described. Finally, the status of J/ψ and that of soft photons and electron pairs are briefly overviewed. (orig.)

  7. Ethical Issues in Engineering Models : Personal Reflections

    NARCIS (Netherlands)

    Kleijnen, Jack P.C.

    2010-01-01

    I start this contribution with an overview of my personal involvement—as an Operations Research consultant—in several engineering case-studies that may raise ethical questions; these case studies employ simulation models. Next, I present an overview of the recent literature on ethical issues in

  8. The Morphological Characteristics and Mechanical Formation of Giant Radial Dike Swarms on Venus: An Overview Emphasizing Recent Numerical Modeling Insights

    Science.gov (United States)

    McGovern, P. J., Jr.; Grosfils, E. B.; Le Corvec, N.; Ernst, R. E.; Galgana, G. A.

    2017-12-01

    Over 200 giant radial dike swarms have been identified on Venus using Magellan data, yielding insight into morphological characteristics long since erased by erosion and other processes on Earth. Since such radial dike systems are typically associated with magma reservoirs, large volcanoes and/or larger-scale plume activity—and because dike geometry reflects stress conditions at the time of intrusion—assessing giant radial dike formation in the context of swarm morphology can place important constraints upon this fundamental volcanotectonic process. Recent numerical models reveal that, contrary to what is reported in much of the published literature, it is not easy, mechanically, to produce either large or small radial dike systems. After extensive numerical examination of reservoir inflation, however, under conditions ranging from a simple halfspace to complex flexural loading, we have thus far identified four scenarios that produce radial dike systems. Two of these scenarios yield dike systems akin to those often associated with shield and stratocone volcanoes on Earth, while the other two, our focus here, are more consistent with the giant radial dike system geometries catalogued on Venus. In this presentation we will (a) review key morphological characteristics of the giant radial systems identified on Venus, (b) briefly illustrate why it is not easy, mechanically, to produce a radial dike system, (c) present the two volcanological circumstances we have identified that do allow a giant radial dike system to form, and (d) discuss current model limitations and potentially fruitful directions for future research.

  9. Software ecosystems – a systematic literature review

    DEFF Research Database (Denmark)

    Manikas, Konstantinos; Hansen, Klaus Marius

    2013-01-01

    A software ecosystem is the interaction of a set of actors on top of a common technological platform that results in a number of software solutions or services. Arguably, software ecosystems are gaining importance with the advent of, e.g., the Google Android, Apache, and Salesforce.com ecosystems....... However, there exists no systematic overview of the research done on software ecosystems from a software engineering perspective. We performed a systematic literature review of software ecosystem research, analyzing 90 papers on the subject taken from a gross collection of 420. Our main conclusions...... are that while research on software ecosystems is increasing (a) there is little consensus on what constitutes a software ecosystem, (b) few analytical models of software ecosystems exist, and (c) little research is done in the context of real-world ecosystems. This work provides an overview of the field, while...

  10. Overview of CSR codes

    International Nuclear Information System (INIS)

    Bassi, G.; Agoh, T.; Dohlus, M.; Giannessi, L.; Hajima, R.; Kabel, A.; Limberg, T.; Quattromini, M.

    2006-01-01

    Coherent synchrotron radiation (CSR) effects play an important role in accelerator physics. CSR effects can be negative (emittance growth in bunch compressors and microbunching instability) or positive (production of CSR in a controlled way). Moreover, CSR is of interest in other fields such as astrophysics. Only a few simple models have been solved analytically. This motivates the development of numerical procedures. In this review article we overview different numerical methods to study CSR effects

  11. Incremental costs associated with myocardial infarction and stroke in patients with type 2 diabetes mellitus: an overview for economic modeling.

    Science.gov (United States)

    Brennan, Victoria K; Colosia, Ann D; Copley-Merriman, Catherine; Mauskopf, Josephine; Hass, Bastian; Palencia, Roberto

    2014-07-01

    To identify cost estimates related to myocardial infarction (MI) or stroke in patients with type 2 diabetes mellitus (T2DM) for use in economic models. A systematic literature review was conducted. Electronic databases and conference abstracts were screened against inclusion criteria, which included studies performed in patients who had T2DM before experiencing an MI or stroke. Primary cost studies and economic models were included. Costs were converted to 2012 pounds sterling. Fifty-four studies were identified: 13 primary cost studies and 41 economic evaluations using secondary sources for complication costs. Primary studies provided costs from 10 countries. Estimates for a fatal event ranged from £2482-£5222 for MI and from £4900-£6694 for stroke. Costs for the year a non-fatal event occurred ranged from £5071-£29,249 for MI and from £5171-£38,732 for stroke. Annual follow-up costs ranged from £945-£1616 for an MI and from £4704-£12,926 for a stroke. Economic evaluations from 12 countries were identified, and costs of complications showed similar variability to the primary studies. The costs identified within primary studies varied between and within countries. Many studies used costs estimated in studies not specific to patients with T2DM. Data gaps included a detailed breakdown of resource use, which affected the ability to compare data across countries. In the development of economic models for patients with T2DM, the use of accurate estimates of costs associated with MI and stroke is important. When country-specific costs are not available, clear justification for the choice of estimates should be provided.

  12. Towards a Conceptual Framework of Sustainable Business Model Innovation in the Agri-Food Sector: A Systematic Literature Review

    Directory of Open Access Journals (Sweden)

    Henrik Barth

    2017-09-01

    Full Text Available This paper aims to increase our understanding of sustainable business model innovation in the agri-food sector in terms of its theoretical and practical approaches for sustainability and their degree of complexity and maturity. The paper is based on a systematic literature review of 570 journal articles on business models and business model innovation published between 1990 and 2014. Of these articles, only 21 have business model innovation as their main focus. The review shows that research interest in the agri-food sector has increased in these years. The paper proposes a conceptual framework for sustainable business model innovation in the agri-food sector that can be used to meet the challenges encountered in taking a sustainability perspective.

  13. Franchise Business Model: Theoretical Insights

    OpenAIRE

    Levickaitė, Rasa; Reimeris, Ramojus

    2010-01-01

    The article is based on literature review, theoretical insights, and deals with the topic of franchise business model. The objective of the paper is to analyse peculiarities of franchise business model and its developing conditions in Lithuania. The aim of the paper is to make an overview on franchise business model and its environment in Lithuanian business context. The overview is based on international and local theoretical insights. In terms of practical meaning, this article should be re...

  14. Developing and Improving Student Non-Technical Skills in IT Education: A Literature Review and Model

    Directory of Open Access Journals (Sweden)

    Marcia Hagen

    2016-06-01

    Full Text Available The purpose of this paper is to identify portions of the literature in the areas of Information Technology (IT management, skills development, and curriculum development that support the design of a holistic conceptual framework for instruction in non-technical skills within the IT higher education context. This article review provides a framework for understanding how the critical success factors related to IT and Information Systems (IS professional success is impacted by developing students’ non-technical skills. The article culminates in a holistic conceptual framework for developing non-technical skills within the IT higher education context. Implications for theory and research are provided.

  15. Using literature and data to learn Bayesian networks as clinical models of ovarian tumors.

    Science.gov (United States)

    Antal, Peter; Fannes, Geert; Timmerman, Dirk; Moreau, Yves; De Moor, Bart

    2004-03-01

    Thanks to its increasing availability, electronic literature has become a potential source of information for the development of complex Bayesian networks (BN), when human expertise is missing or data is scarce or contains much noise. This opportunity raises the question of how to integrate information from free-text resources with statistical data in learning Bayesian networks. Firstly, we report on the collection of prior information resources in the ovarian cancer domain, which includes "kernel" annotations of the domain variables. We introduce methods based on the annotations and literature to derive informative pairwise dependency measures, which are derived from the statistical cooccurrence of the names of the variables, from the similarity of the "kernel" descriptions of the variables and from a combined method. We perform wide-scale evaluation of these text-based dependency scores against an expert reference and against data scores (the mutual information (MI) and a Bayesian score). Next, we transform the text-based dependency measures into informative text-based priors for Bayesian network structures. Finally, we report the benefit of such informative text-based priors on the performance of a Bayesian network for the classification of ovarian tumors from clinical data.

  16. Neurocognitive poetics: methods and models for investigating the neuronal and cognitive-affective bases of literature reception.

    Science.gov (United States)

    Jacobs, Arthur M

    2015-01-01

    A long tradition of research including classical rhetoric, esthetics and poetics theory, formalism and structuralism, as well as current perspectives in (neuro)cognitive poetics has investigated structural and functional aspects of literature reception. Despite a wealth of literature published in specialized journals like Poetics, however, still little is known about how the brain processes and creates literary and poetic texts. Still, such stimulus material might be suited better than other genres for demonstrating the complexities with which our brain constructs the world in and around us, because it unifies thought and language, music and imagery in a clear, manageable way, most often with play, pleasure, and emotion (Schrott and Jacobs, 2011). In this paper, I discuss methods and models for investigating the neuronal and cognitive-affective bases of literary reading together with pertinent results from studies on poetics, text processing, emotion, or neuroaesthetics, and outline current challenges and future perspectives.

  17. A review of the literature to inform a best-practice clinical supervision model for midwifery students in Australia.

    Science.gov (United States)

    McKellar, Lois; Graham, Kristen

    2017-05-01

    Effective clinical supervision in midwifery programs leading to registration is essential to ensure that students can provide safe and competent woman centred care by the completion of their program. A number of different clinical supervision models exist in Australia and internationally, with varying levels of support and facilitation of student learning opportunities. In Australia, midwifery students must achieve specified learning outcomes and midwifery practice requirements to be eligible to register as a midwife. Identifying a best practice clinical supervision model for Australian midwifery students is therefore a priority for all key stakeholders, particularly education and maternity care providers. The aim of this literature review was to explore different types of clinical supervision models in order to develop and implement a best practice model in midwifery education programs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. RETRAN overview

    International Nuclear Information System (INIS)

    Agee, L.J.

    1985-01-01

    The RETRAN code has become the industry standard with respect to NSSS transient analysis. The objective of this paper is to present an overview of important RETRAN-related events since the second International meeting in April of 1982. This paper is divided into three parts. The first part addresses the current status of the code with emphasis on the design review of RETRAN-02 MOD002 and the goal of RETRAN-02 in the Reactor Analysis Support Package (RASP). These activities are being undertaken to simplify the use of RETRAN for safety analysis and reload application which may be part of an NRC submittal. The second part of the paper describes significant applications of RETRAN. In the analysis section, special emphasis is placed on validation analyses which compare the code to actual plant data or experimental facilities. The third section briefly describes the pre-release version of RETRAN and the developmental goals for the next version of RETRAN. One major limitation of all state-of-the-art thermal-hydraulic codes is the determination of the structure of the fluid. A brief description of research needs in this are indicated

  19. Markov modeling for the neurosurgeon: a review of the literature and an introduction to cost-effectiveness research.

    Science.gov (United States)

    Wali, Arvin R; Brandel, Michael G; Santiago-Dieppa, David R; Rennert, Robert C; Steinberg, Jeffrey A; Hirshman, Brian R; Murphy, James D; Khalessi, Alexander A

    2018-05-01

    OBJECTIVE Markov modeling is a clinical research technique that allows competing medical strategies to be mathematically assessed in order to identify the optimal allocation of health care resources. The authors present a review of the recently published neurosurgical literature that employs Markov modeling and provide a conceptual framework with which to evaluate, critique, and apply the findings generated from health economics research. METHODS The PubMed online database was searched to identify neurosurgical literature published from January 2010 to December 2017 that had utilized Markov modeling for neurosurgical cost-effectiveness studies. Included articles were then assessed with regard to year of publication, subspecialty of neurosurgery, decision analytical techniques utilized, and source information for model inputs. RESULTS A total of 55 articles utilizing Markov models were identified across a broad range of neurosurgical subspecialties. Sixty-five percent of the papers were published within the past 3 years alone. The majority of models derived health transition probabilities, health utilities, and cost information from previously published studies or publicly available information. Only 62% of the studies incorporated indirect costs. Ninety-three percent of the studies performed a 1-way or 2-way sensitivity analysis, and 67% performed a probabilistic sensitivity analysis. A review of the conceptual framework of Markov modeling and an explanation of the different terminology and methodology are provided. CONCLUSIONS As neurosurgeons continue to innovate and identify novel treatment strategies for patients, Markov modeling will allow for better characterization of the impact of these interventions on a patient and societal level. The aim of this work is to equip the neurosurgical readership with the tools to better understand, critique, and apply findings produced from cost-effectiveness research.

  20. Research trends on Big Data in Marketing: A text mining and topic modeling based literature analysis

    Directory of Open Access Journals (Sweden)

    Alexandra Amado

    2018-01-01

    Full Text Available Given the research interest on Big Data in Marketing, we present a research literature analysis based on a text mining semi-automated approach with the goal of identifying the main trends in this domain. In particular, the analysis focuses on relevant terms and topics related with five dimensions: Big Data, Marketing, Geographic location of authors’ affiliation (countries and continents, Products, and Sectors. A total of 1560 articles published from 2010 to 2015 were scrutinized. The findings revealed that research is bipartite between technological and research domains, with Big Data publications not clearly aligning cutting edge techniques toward Marketing benefits. Also, few inter-continental co-authored publications were found. Moreover, findings show that research in Big Data applications to Marketing is still in an embryonic stage, thus making it essential to develop more direct efforts toward business for Big Data to thrive in the Marketing arena.

  1. The SDM 3 Circle Model: A Literature Synthesis and Adaptation for Shared Decision Making in the Hospital.

    Science.gov (United States)

    Rennke, Stephanie; Yuan, Patrick; Monash, Brad; Blankenburg, Rebecca; Chua, Ian; Harman, Stephanie; Sakai, Debbie S; Khan, Adeena; Hilton, Joan F; Shieh, Lisa; Satterfield, Jason

    2017-12-01

    Patient engagement through shared decision-making (SDM) is increasingly seen as a key component for patient safety, patient satisfaction, and quality of care. Current SDM models do not adequately account for medical and environmental contexts, which may influence medical decisions in the hospital. We identified leading SDM models and reviews to inductively construct a novel SDM model appropriate for the inpatient setting. A team of medicine and pediatric hospitalists reviewed the literature to integrate core SDM concepts and processes and iteratively constructed a synthesized draft model. We then solicited broad SDM expert feedback on the draft model for validation and further refinement. The SDM 3 Circle Model identifies 3 core categories of variables that dynamically interact within an "environmental frame." The resulting Venn diagram includes overlapping circles for (1) patient/family, (2) provider/team, and (3) medical context. The environmental frame includes all external, contextual factors that may influence any of the 3 circles. Existing multistep SDM process models were then rearticulated and contextualized to illustrate how a shared decision might be made. The SDM 3 Circle Model accounts for important environmental and contextual characteristics that vary across settings. The visual emphasis generated by each "circle" and by the environmental frame direct attention to often overlooked interactive forces and has the potential to more precisely define, promote, and improve SDM. This model provides a framework to develop interventions to improve quality and patient safety through SDM and patient engagement for hospitalists. © 2017 Society of Hospital Medicine.

  2. Ethical Issues in Engineering Models : Personal Reflections

    OpenAIRE

    Kleijnen, Jack P.C.

    2010-01-01

    I start this contribution with an overview of my personal involvement—as an Operations Research consultant—in several engineering case-studies that may raise ethical questions; these case studies employ simulation models. Next, I present an overview of the recent literature on ethical issues in modeling, focusing on the validation of the model’s assumptions; the decisive role of these assumptions leads to the quest for robust models. Actually, models are meant to solve practical problems; the...

  3. 3D Anatomy Models and Impact on Learning: A Review of the Quality of the Literature

    Directory of Open Access Journals (Sweden)

    Samy A. Azer

    2016-12-01

    Conclusions: There was no solid evidence that the use of 3D models is superior to traditional teaching. However, the studies varied in research quality. More studies are needed to examine the short- and long-term impacts of 3D models on learning using valid and appropriate tools.

  4. Photoionization modelling of planetary nebulae - II. Galactic bulge nebulae, a comparison with literature results

    NARCIS (Netherlands)

    van Hoof, PAM; Van de Steene, GC

    1999-01-01

    We have constructed photoionization models of five galactic bulge planetary nebulae using our automatic method, which enables a fully self-consistent determination of the physical parameters of a planetary nebula. The models are constrained using the spectrum, the IRAS and radio fluxes and the

  5. A systematic literature review of studies on business process modeling quality

    NARCIS (Netherlands)

    Moreno-Montes de Oca, I.; Snoeck, M.; Reijers, H.A.; Rodríguez-Morffi, A.

    2015-01-01

    Context. Business process modeling is an essential part of understanding and redesigning the activities that a typical enterprise uses to achieve its business goals. The quality of a business process model has a significant impact on the development of any enterprise and IT support for that process.

  6. A systematic literature review of studies on business process modeling quality

    NARCIS (Netherlands)

    Moreno-Montes de Oca, I.; Snoeck, M.; Reijers, H.A.; Rodríguez-Morffi, A.

    2015-01-01

    Context: Business process modeling is an essential part of understanding and redesigning the activities that a typical enterprise uses to achieve its business goals. The quality of a business process model has a significant impact on the development of any enterprise and IT support for that process.

  7. Retrievability: An international overview

    International Nuclear Information System (INIS)

    Richardson, P.J.

    2000-01-01

    Using available information from the published literature and material obtained from a network of contacts, a short introductory overview of international developments in the field of retrievability of emplaced nuclear waste was produced for the Swedish National Siting Coordinator for Nuclear Waste Disposal. This examined the issue in terms of a number of basic questions: Definition, Need, Design Implications, Safeguards for Fissile Material, Public Acceptability and Safety Assessment. The report was submitted in February 1999, and acted as a catalyst for the organisation of an international seminar by KASAM, the Swedish National Council for Nuclear Waste (these proceedings). This paper describes the report contents, and points to the invited papers at the seminar which expand on and update the limited descriptions in the original report. (author)

  8. Model-Based Economic Evaluation of Treatments for Depression: A Systematic Literature Review

    DEFF Research Database (Denmark)

    Kolovos, Spyros; Bosmans, Judith E.; Riper, Heleen

    2017-01-01

    eligible if they used a health economic model with quality-adjusted life-years or disability-adjusted life-years as an outcome measure. Data related to various methodological characteristics were extracted from the included studies. The available modelling techniques were evaluated based on 11 predefined......, and DES models in seven.ConclusionThere were substantial methodological differences between the studies. Since the individual history of each patient is important for the prognosis of depression, DES and ISM simulation methods may be more appropriate than the others for a pragmatic representation...

  9. Cultural competence in end-of-life care: terms, definitions, and conceptual models from the British literature.

    Science.gov (United States)

    Evans, Natalie; Meñaca, Arantza; Koffman, Jonathan; Harding, Richard; Higginson, Irene J; Pool, Robert; Gysels, Marjolein

    2012-07-01

    Cultural competency is increasingly recommended in policy and practice to improve end-of-life (EoL) care for minority ethnic groups in multicultural societies. It is imperative to critically analyze this approach to understand its underlying concepts. Our aim was to appraise cultural competency approaches described in the British literature on EoL care and minority ethnic groups. This is a critical review. Articles on cultural competency were identified from a systematic review of the literature on minority ethnic groups and EoL care in the United Kingdom. Terms, definitions, and conceptual models of cultural competency approaches were identified and situated according to purpose, components, and origin. Content analysis of definitions and models was carried out to identify key components. One-hundred thirteen articles on minority ethnic groups and EoL care in the United Kingdom were identified. Over half (n=60) contained a term, definition, or model for cultural competency. In all, 17 terms, 17 definitions, and 8 models were identified. The most frequently used term was "culturally sensitive," though "cultural competence" was defined more often. Definitions contained one or more of the components: "cognitive," "implementation," or "outcome." Models were categorized for teaching or use in patient assessment. Approaches were predominantly of American origin. The variety of terms, definitions, and models underpinning cultural competency approaches demonstrates a lack of conceptual clarity, and potentially complicates implementation. Further research is needed to compare the use of cultural competency approaches in diverse cultures and settings, and to assess the impact of such approaches on patient outcomes.

  10. Gatekeeper Training for Suicide Prevention: A Theoretical Model and Review of the Empirical Literature

    Science.gov (United States)

    2015-01-01

    effectiveness of such trainings or of intervention behaviors. The model is consistent with Bandura’s social cognitive theory , which posits that...interactions between environmental and personal factors influence the learning of new behav- ior ( Bandura , 2001). The model is depicted in Figure 1. In the...A., “ Social Cognitive Theory : An Agentic Perspective,” Annual Review of Clinical Psychology, Vol. 52, 2001, pp. 1–26. Bean, G., and K. M. Baber

  11. Postmortem aviation forensic toxicology: an overview.

    Science.gov (United States)

    Chaturvedi, Arvind K

    2010-05-01

    An overview of the subtopic aviation combustion toxicology of the field of aerospace toxicology has been published. In a continuation of the overview, the findings associated with postmortem aviation forensic toxicology are being summarized in the present overview. A literature search for the period of 1960-2007 was performed. The important findings related to postmortem toxicology were evaluated. In addition to a brief introduction, this overview is divided into the sections of analytical methods; carboxyhemoglobin and blood cyanide ion; ethanol; drugs; result interpretation; glucose and hemoglobin A(1c); and references. Specific details of the subject matter were discussed. It is anticipated that this overview will be an outline source for aviation forensic toxicology within the field of aerospace toxicology.

  12. Mouse models in liver cancer research: A review of current literature

    Science.gov (United States)

    Leenders, Martijn WH; Nijkamp, Maarten W; Rinkes, Inne HM Borel

    2008-01-01

    Primary liver cancer remains one of the most lethal malignancies worldwide. Due to differences in prevalence of etiological factors the incidence of primary liver cancer varies among the world, with a peak in East-Asia. As this disease is still lethal in most of the cases, research has to be done to improve our understanding of the disease, offering insights for possible treatment options. For this purpose, animal models are widely used, especially mouse models. In this review, we describe the different types of mouse models used in liver cancer research, with emphasis on genetically engineered mice used in this field. We focus on hepatocellular carcinoma (HCC), as this is by far the most common type of primary liver cancer, accounting for 70%-85% of cases. PMID:19058325

  13. Dynamic modeling approaches to characterize the functioning of health systems: A systematic review of the literature.

    Science.gov (United States)

    Chang, Angela Y; Ogbuoji, Osondu; Atun, Rifat; Verguet, Stéphane

    2017-12-01

    Universal Health Coverage (UHC) is one of the targets for the United Nations Sustainable Development Goal 3. The impetus for UHC has led to an increased demand for time-sensitive tools to enhance our knowledge of how health systems function and to evaluate impact of system interventions. We define the field of "health system modeling" (HSM) as an area of research where dynamic mathematical models can be designed in order to describe, predict, and quantitatively capture the functioning of health systems. HSM can be used to explore the dynamic relationships among different system components, including organizational design, financing and other resources (such as investments in resources and supply chain management systems) - what we call "inputs" - on access, coverage, and quality of care - what we call "outputs", toward improved health system "outcomes", namely increased levels and fairer distributions of population health and financial risk protection. We undertook a systematic review to identify the existing approaches used in HSM. We identified "systems thinking" - a conceptual and qualitative description of the critical interactions within a health system - as an important underlying precursor to HSM, and collated a critical collection of such articles. We then reviewed and categorized articles from two schools of thoughts: "system dynamics" (SD)" and "susceptible-infected-recovered-plus" (SIR+). SD emphasizes the notion of accumulations of stocks in the system, inflows and outflows, and causal feedback structure to predict intended and unintended consequences of policy interventions. The SIR + models link a typical disease transmission model with another that captures certain aspects of the system that impact the outcomes of the main model. These existing methods provide critical insights in informing the design of HSM, and provide a departure point to extend this research agenda. We highlight the opportunity to advance modeling methods to further understand

  14. Relationships between road safety, safety measures and external factors : a scan of the literature in view of model development and topics for further research.

    NARCIS (Netherlands)

    Churchill, T. & Norden, Y. van

    2010-01-01

    The purpose of this literature scan is to examine where literature on the effect of external factors and road safety measures on road safety exists and where it is lacking. This scan will help us to decide which factors to include in a comprehensive road safety model as SWOV is working on, and at

  15. Total Productive Maintenance And Role Of Interpretive Structural Modeling And Structural Equation Modeling In Analyzing Barriers In Its Implementation A Literature Review

    Directory of Open Access Journals (Sweden)

    Prasanth S. Poduval

    2015-08-01

    Full Text Available Abstract - The aim of the authors is to present a review of literature of Total Productive Maintenance and the barriers in implementation of Total Productive Maintenance TPM. The paper begins with a brief description of TPM and the barriers in implementation of TPM. Interpretive Structural Modeling ISM and its role in analyzing the barriers in TPM implementation is explained in brief. Applications of ISM in analyzing issues in various fields are highlighted with special emphasis on TPM. The paper moves on to introduction to Structural Equation Modeling SEM and its role in validating ISM in analyzing barriers in implementation of TPM. The paper concludes with a gap analysis from the current literature research that can be carried out and expected outcomes from the proposed research.

  16. Impact of parental acquired brain injury on children: Review of the literature and conceptual model.

    Science.gov (United States)

    Tiar, Anna Maria Vitale; Dumas, Jean E

    2015-01-01

    Data on children's adjustment following parental acquired brain injury (ABI) are disparate and spare, and appear inconclusive. Nonetheless, they suggest that children's well-being is at risk, but often neglected. Indeed, lack of a unifying conceptual model makes it difficult to integrate available evidence, in order to circumscribe relevant factors and understand how these may influence children's outcomes in more or less favourable ways. The present review proposes the coping competence model as a theoretical framework apt to clarify these issues and organize the available evidence. In brief, the model states that impact of parental ABI on children reflects the extent of the challenges children face and their preponderant ways of coping with them, i.e. pro-socially, anti-socially or asocially. Evidence shows that children deal with some common socioaffective as well as achievement challenges. Further, it is consistent with the three main coping modalities supported by the model. Overall, children's outcomes appear variable, but clearly at risk and in need of special attention. This review summarizes these outcomes, raises conceptual as well as methodological questions to be addressed in future research and eventually presents relevant issues for support and clinical services.

  17. Applications of Diagnostic Classification Models: A Literature Review and Critical Commentary

    Science.gov (United States)

    Sessoms, John; Henson, Robert A.

    2018-01-01

    Diagnostic classification models (DCMs) classify examinees based on the skills they have mastered given their test performance. This classification enables targeted feedback that can inform remedial instruction. Unfortunately, applications of DCMs have been criticized (e.g., no validity support). Generally, these evaluations have been brief and…

  18. Higher Education Program Curricula Models in Tourism and Hospitality Education: A Review of the Literature

    Science.gov (United States)

    Scotland, Miriam

    2006-01-01

    The relevancy of program curricula in tourism and hospitality education has been called into question by key stakeholders in light of ongoing changes in the multifaceted tourism and hospitality industry. Various program models have been identified. Program content and quality of student preparedness have been debated. Balance and areas of emphasis…

  19. A community-driven open data lifecycle model based on literature and practice

    NARCIS (Netherlands)

    Veenstra, A.F. van; Broek, T.A. van den

    2015-01-01

    Government organizations around the world have developed open data strategies to increase transparency and enable re-use of their data. However, in practice, many organizations find the process of opening up their data cumbersome and they do not know which steps to take. Lifecycle models can guide

  20. Job Stress, Employee Health, and Organizational Effectiveness: A Facet Analysis, Model, and Literature Review.

    Science.gov (United States)

    Beehr, Terry A.; Newman, John E.

    1978-01-01

    The empirical research on job stress and employee health is reviewed within the context of six facets (environmental, personal, process, human consequences, organizational consequences, and time) of a seven facet conceptualization of the job stress-employee health research domain. Models are proposed for tying the facets together. (Author/SJL)

  1. Mathematical models for the definition of cell manufacturing layout. Literature review

    Directory of Open Access Journals (Sweden)

    Gustavo Andrés Romero Duque

    2015-11-01

    Full Text Available This review article discusses the approach to the layout problem of cell manufacturing (LCM in a descriptive form; considering at first the problem and its variations, then the elements of the mathematical models, subsequently presenting solution methods used; and finally some future perspectives about this topic are considered.

  2. Total Productive Maintenance And Role Of Interpretive Structural Modeling And Structural Equation Modeling In Analyzing Barriers In Its Implementation A Literature Review

    OpenAIRE

    Prasanth S. Poduval; Dr. Jagathy Raj V. P.; Dr. V. R. Pramod

    2015-01-01

    Abstract - The aim of the authors is to present a review of literature of Total Productive Maintenance and the barriers in implementation of Total Productive Maintenance TPM. The paper begins with a brief description of TPM and the barriers in implementation of TPM. Interpretive Structural Modeling ISM and its role in analyzing the barriers in TPM implementation is explained in brief. Applications of ISM in analyzing issues in various fields are highlighted with special emphasis on TPM. T...

  3. Strengthening Industrial Ecology’s Links with Business Studies: Insights and Potential Contributions from the Innovation and Business Models Literature

    Directory of Open Access Journals (Sweden)

    Samantha Sharpe

    2014-03-01

    Full Text Available The declining availability of natural resources and the environmental impacts of continued extraction of primary resources for production activities have forced greater focus on waste streams and recycling activities. Industrial ecology as a field of practice and theory has been closely related to sustainability issues, yet despite the development of much theory and specific tools and methodologies, the link between natural, industrial and economic systems is not convincing. Not only that, the need for delivering sustainable production and consumption practices is increasing, which is demanding new solutions to existing problems, particularly around the degree of novelty. The interaction of industrial ecology with business studies and industrial investment decision-making remains under-developed, and this is likely impacting on the adoption of more sustainable and resource-efficient practices. As such, this paper uses a constructive approach and explores how two areas of the literature can support the development of the industrial ecology field into strategic business practice: firstly, the innovation literature, particularly the emerging work on open innovation and sustainable innovation as a model to understand radical innovation processes and the creation and maintenance of networked systems of firms; secondly, the closely related area of business model (BM innovation, specifically the emerging typologies of sustainable BMs and how these typologies can be developed and used as a route to positioning recycling activities at the strategic management level of the firm.

  4. An overview of regional and local characteristics of aerosols in South Africa using satellite, ground, and modeling data

    Science.gov (United States)

    Hersey, S. P.; Garland, R. M.; Crosbie, E.; Shingler, T.; Sorooshian, A.; Piketh, S.; Burger, R.

    2014-09-01

    We present a comprehensive overview of particulate air quality across the five major metropolitan areas of South Africa (Cape Town, Bloemfontein, Johannesburg and Tshwane (Gauteng Province), the Industrial Highveld Air Quality Priority Area (HVAPA), and Durban), based on a decadal (1 January 2000 to 31 December 2009) aerosol climatology from multiple satellite platforms and a detailed analysis of ground-based data from 19 sites throughout Gauteng. Data include Aerosol Optical Depth (AOD550, 555) from Aqua (550 nm), Terra (550 nm), and MISR (555 nm) platforms, Ängström Exponent (α550/865, 470/660) from Aqua (550/865 nm) and Terra (470/660 nm), Ultraviolet Aerosol Index (UVAI) from TOMS, and model results from the Goddard Ozone Chemistry Aerosol Radiation and Transport (GOCART) model. Results in Cape Town are distinct, owing to a typically clean, marine airmass origin and infrequent continental influence. At continentally-influenced sites, AOD550, AOD555, α550/865, α470/660 and UVAI reach maxima (0.12-0.20, 1.0-1.8, and 1.0-1.2, respectively) during late winter and early spring (August-October), coinciding with a period of enhanced dust generation and the maximum frequency of close-proximity and subtropical fires identified by MODIS Fire Information for Resource Management System (FIRMS). The adjacent metropolitan and industrial Gauteng and HVAPA areas have been identified as a megacity based on NO2 concentrations, but AOD is a factor of 3-6 lower than other megacities worldwide. GOCART results suggest that the contributions of organics and black carbon to AOD are significantly enhanced during biomass burning season (ASO), but that sulfate is the most significant contributor to AOD (~70-80%) through the rest of the year. Dust appears to be underestimated by GOCART emissions inventories at continentally-influenced metropolitan areas of South Africa. Ground monitoring sites were classified according to site type: (1) township and informal settlement sites with

  5. The Interaction Network Ontology-supported modeling and mining of complex interactions represented with multiple keywords in biomedical literature.

    Science.gov (United States)

    Özgür, Arzucan; Hur, Junguk; He, Yongqun

    2016-01-01

    The Interaction Network Ontology (INO) logically represents biological interactions, pathways, and networks. INO has been demonstrated to be valuable in providing a set of structured ontological terms and associated keywords to support literature mining of gene-gene interactions from biomedical literature. However, previous work using INO focused on single keyword matching, while many interactions are represented with two or more interaction keywords used in combination. This paper reports our extension of INO to include combinatory patterns of two or more literature mining keywords co-existing in one sentence to represent specific INO interaction classes. Such keyword combinations and related INO interaction type information could be automatically obtained via SPARQL queries, formatted in Excel format, and used in an INO-supported SciMiner, an in-house literature mining program. We studied the gene interaction sentences from the commonly used benchmark Learning Logic in Language (LLL) dataset and one internally generated vaccine-related dataset to identify and analyze interaction types containing multiple keywords. Patterns obtained from the dependency parse trees of the sentences were used to identify the interaction keywords that are related to each other and collectively represent an interaction type. The INO ontology currently has 575 terms including 202 terms under the interaction branch. The relations between the INO interaction types and associated keywords are represented using the INO annotation relations: 'has literature mining keywords' and 'has keyword dependency pattern'. The keyword dependency patterns were generated via running the Stanford Parser to obtain dependency relation types. Out of the 107 interactions in the LLL dataset represented with two-keyword interaction types, 86 were identified by using the direct dependency relations. The LLL dataset contained 34 gene regulation interaction types, each of which associated with multiple keywords. A

  6. Exploring the Group Prenatal Care Model: A Critical Review of the Literature

    Science.gov (United States)

    Thielen, Kathleen

    2012-01-01

    Few studies have compared perinatal outcomes between individual prenatal care and group prenatal care. A critical review of research articles that were published between 1998 and 2009 and involved participants of individual and group prenatal care was conducted. Two middle range theories, Pender’s health promotion model and Swanson’s theory of caring, were blended to enhance conceptualization of the relationship between pregnant women and the group prenatal care model. Among the 17 research studies that met inclusion criteria for this critical review, five examined gestational age and birth weight with researchers reporting longer gestations and higher birth weights in infants born to mothers participating in group prenatal care, especially in the preterm birth population. Current evidence demonstrates that nurse educators and leaders should promote group prenatal care as a potential method of improving perinatal outcomes within the pregnant population. PMID:23997549

  7. Dynamic panel data models

    NARCIS (Netherlands)

    Bun, M.J.G.; Sarafidis, V.

    2013-01-01

    This Chapter reviews the recent literature on dynamic panel data models with a short time span and a large cross-section. Throughout the discussion we considerlinear models with additional endogenous covariates. First we give a broad overview of available inference methods placing emphasis on GMM.

  8. Fatigue and fracture: Overview

    Science.gov (United States)

    Halford, G. R.

    1984-01-01

    A brief overview of the status of the fatigue and fracture programs is given. The programs involve the development of appropriate analytic material behavior models for cyclic stress-strain-temperature-time/cyclic crack initiation, and cyclic crack propagation. The underlying thrust of these programs is the development and verification of workable engineering methods for the calculation, in advance of service, of the local cyclic stress-strain response at the critical life governing location in hot section compounds, and the resultant crack initiation and crack growth lifetimes.

  9. Overview of particle physics

    International Nuclear Information System (INIS)

    Salam, A.

    1993-01-01

    This article presents an overview of the situation in particle physics and a prognosis of its future: ideas which have been tested or will soon be tested (standard model and the light Higgs particle), ideas whose time has not yet come (supersymmetry, supersymmetry and N=1 supergravity, right-left symmetry and preons, unification of gravity with other forces, anomaly-free supergravities, supersymmetry strings, string theory as the ''Theory of Everything'' (T.O.E.); passive and non accelerator experiments. 6 figs., 2 tabs

  10. Literature review on future development of the Baltic Sea and recommendations for safety modeling

    International Nuclear Information System (INIS)

    Lahdenperae, A.-M.

    2006-12-01

    The report represents the summary of the main factors, which affects the future development and state of the Baltic Sea. The emphasis is on land uplift, shoreline displacement, and physical, chemical and biological characteristics of the sea. In addition, historical evolution of the Baltic Sea after the last ice age and potential impacts of the different climate scenarios are presented. The Baltic Sea has an important influence on the development of the geospherebiosphere interface zone at Olkiluoto. Thus, it is important to take account all these factors in the Safety Modelling of the nuclear waste repository. Different models have been used to evaluate land uplift at Olkiluoto and changes in the sea and land area, especially in the interface zone. The main parameters have been monitored satisfactory way at the Olkiluoto offshore. Based on the present sea sediment stratigraphy, overburden, topography and vegetation it has been fairly well estimated coming future land and sea areas of the Olkiluoto Island and its surroundings. According to the results, Olkiluoto will be part of the continent during the next decade. In the shallow shores of Olkiluoto, the amounts of common reed are increasing naturally, resulting in paludification. The spatial and temporal changes at Olkiluoto can be estimated and modelled more detailed by using the well focused research sites and more accurate results. In addition, more information is needed on development of the watershed areas, lakes, rivers and vegetation and on sedimentation and erosion processes, hydrology, quality and quantity of seabed sediments and stratigraphy, element budgets and recharge and discharge areas, especially at the geosphere-biosphere interface zones. (orig.)

  11. An overview of CFD modelling of small-scale fixed-bed biomass pellet boilers with preliminary results from a simplified approach

    International Nuclear Information System (INIS)

    Chaney, Joel; Liu Hao; Li Jinxing

    2012-01-01

    Highlights: ► Overview of the overall approach of modelling fixed-bed biomass boilers in CFD. ► Bed sub-models of moisture evaporation, devolatisation and char combustion reviewed. ► A method of embedding a combustion model in discrete fuel zones within the CFD is suggested. ► Includes sample of preliminary results for a 50 kW pellet boiler. ► Clear physical trends predicted. - Abstract: The increasing global energy demand and mounting pressures for CO 2 mitigation call for increased efficient utilization of biomass, particularly for heating domestic and commercial buildings. The authors of the present paper are investigating the optimization of the combustion performance and NO x emissions of a 50 kW biomass pellet boiler fabricated by a UK manufacturer. The boiler has a number of adjustable parameters including the ratio of air flow split between the primary and secondary supplies, the orientation, height, direction and number of the secondary inlets. The optimization of these parameters provides opportunities to improve both the combustion efficiency and NO x emissions. When used carefully in conjunction with experiments, Computational Fluid Dynamics (CFD) modelling is a useful tool for rapidly and at minimum cost examining the combustion performance and emissions from a boiler with multiple variable parameters. However, modelling combustion and emissions of a small-scale biomass pellet boiler is not trivial and appropriate fixed-bed models that can be coupled with the CFD code are required. This paper reviews previous approaches specifically relevant to simulating fixed-bed biomass boilers. In the first part it considers approaches to modelling the heterogeneous solid phase and coupling this with the gas phase. The essential components of the sub-models are then overviewed. Importantly, for the optimization process a model is required that has a good balance between accuracy in predicting physical trends, with low computational run time. Finally, a

  12. Neuroprotective properties of curcumin in toxin-base animal models of Parkinson's disease: a systematic experiment literatures review.

    Science.gov (United States)

    Wang, Xin-Shi; Zhang, Zeng-Rui; Zhang, Man-Man; Sun, Miao-Xuan; Wang, Wen-Wen; Xie, Cheng-Long

    2017-08-17

    Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is widely used in Southeast Asia, China and India in food preparation and for medicinal purposes. Meanwhile, the neuroprotective actions of curcumin have been documented for experimental therapy in Parkinson's disease (PD). In this study, we used a systematic review to comprehensively assess the efficacy of curcumin in experimental PD. Using electronic and manual search for the literatures, we identified studies describing the efficacy of curcumin in animal models of PD. We identified 13 studies with a total of 298 animals describing the efficacy of curcumin in animal models of PD. The methodological quality of all preclinical trials is ranged from 2 to 5. The majority of the experiment studies demonstrated that curcumin was more significantly neuroprotection effective than control groups for treating PD. Among them, five studies indicated that curcumin had an anti-inflammatory effect in the PD animal models (p curcumin, by which it protected substantia nigra neurons and improved striatal dopamine levels. Furthermore, two studies in this review displayed that curcumin treatment was also effective in reducing neuronal apoptosis and improving functional outcome in animal models of PD. Most of the preclinical studies demonstrated the positive findings while one study reported that curcumin had no beneficial effects against Mn-induced disruption of hippocampal metal and neurotransmitter homeostasis. The results demonstrated a marked efficacy of curcumin in experimental model of PD, suggesting curcumin probably a candidate neuroprotective drug for human PD patients.

  13. Literature Reviews on Modeling Internal Geometry of Textile Composites and Rate-Independent Continuum Damage

    Science.gov (United States)

    Su-Yuen, Hsu

    2011-01-01

    Textile composite materials have good potential for constructing composite structures where the effects of three-dimensional stresses are critical or geometric complexity is a manufacturing concern. There is a recent interest in advancing competence within Langley Research Center for modeling the degradation of mechanical properties of textile composites. In an initial effort, two critical areas are identified to pursue: (1) Construction of internal geometry of textile composites, and (2) Rate-independent continuum damage mechanics. This report documents reviews on the two subjects. Various reviewed approaches are categorized, their assumptions, methods, and progress are briefed, and then critiques are presented. Each review ends with recommended research.

  14. Numerical Modelling of Mechanical Integrity of the Copper-Cast Iron Canister. A Literature Review

    International Nuclear Information System (INIS)

    Lanru Jing

    2004-04-01

    This review article presents a summary of the research works on the numerical modelling of the mechanical integrity of the composite copper-cast iron canisters for the final disposal of Swedish nuclear wastes, conducted by SKB and SKI since 1992. The objective of the review is to evaluate the outstanding issues existing today about the basic design concepts and premises, fundamental issues on processes, properties and parameters considered for the functions and requirements of canisters under the conditions of a deep geological repository. The focus is placed on the adequacy of numerical modelling approaches adopted in regards to the overall mechanical integrity of the canisters, especially the initial state of canisters regarding defects and the consequences of their evolution under external and internal loading mechanisms adopted in the design premises. The emphasis is the stress-strain behaviour and failure/strength, with creep and plasticity involved. Corrosion, although one of the major concerns in the field of canister safety, was not included

  15. Lattice overview

    International Nuclear Information System (INIS)

    Creutz, M.

    1984-01-01

    After reviewing some recent developments in supercomputer access, the author discusses a few areas where perturbation theory and lattice gauge simulations make contact. The author concludes with a brief discussion of a deterministic dynamics for the Ising model. This may be useful for numerical studies of nonequilibrium phenomena. 13 references

  16. Experimental identification and analytical modelling of human walking forces: Literature review

    Science.gov (United States)

    Racic, V.; Pavic, A.; Brownjohn, J. M. W.

    2009-09-01

    Dynamic forces induced by humans walking change simultaneously in time and space, being random in nature and varying considerably not only between different people but also for a single individual who cannot repeat two identical steps. Since these important aspects of walking forces have not been adequately researched in the past, the corresponding lack of knowledge has reflected badly on the quality of their mathematical models used in vibration assessments of pedestrian structures such as footbridges, staircases and floors. To develop better force models which can be used with more confidence in the structural design, an adequate experimental and analytical approach must be taken to account for their complexity. This paper is the most comprehensive review published to date, of 270 references dealing with different experimental and analytical characterizations of human walking loading. The source of dynamic human-induced forces is in fact in the body motion. To date, human motion has attracted a lot of interest in many scientific branches, particularly in medical and sports science, bioengineering, robotics, and space flight programs. Other fields include biologists of various kinds, physiologists, anthropologists, computer scientists (graphics and animation), human factors and ergonomists, etc. It resulted in technologically advanced tools that can help understanding the human movement in more detail. Therefore, in addition to traditional direct force measurements utilizing a force plate and an instrumented treadmill, this review also introduces methods for indirect measurement of time-varying records of walking forces via combination of visual motion tracking (imaging) data and known body mass distribution. The review is therefore an interdisciplinary article that bridges the gaps between biomechanics of human gait and civil engineering dynamics. Finally, the key reason for undertaking this review is the fact that human-structure dynamic interaction and

  17. Surface Generation Modeling in Ball Nose End Milling: a review of relevant literature

    DEFF Research Database (Denmark)

    Bissacco, Giuliano

    One of the most common metal removal operation used in industry is the milling process. This machining process is well known since the beginning of last century and has experienced, along the years, many improvements of the basic technology, as concerns tools, machine tools, coolants...... to be adjusted afterwards. Nevertheless, many efforts have been done during the last 50 years in order to realize prediction tools for machining processes and particularly for conventional turning and milling operations. Most of these models aim at prediction of cutting forces tool wear and tool life. However...... been addressed in this direction. Among all the machining operations, ball nose end milling has shown great potentials, particularly in machining of sculptured surfaces with high requirements in terms of surface finish; this is due to the good spatial agreement of the mill shape with the geometry...

  18. A literature review on growth models and strategies: The missing link in entrepreneurial growth

    Directory of Open Access Journals (Sweden)

    Syed Fida Hussain Shah

    2013-08-01

    Full Text Available This study focuses on the importance of growth models, growth strategies, role of knowledge management system in the formulation of effective strategy for the enterprises following growth. Choice of an appropriate growth strategy is at the heart of any successful entrepreneurial venture. Selection of a strategy may be effective for one entrepreneur while it is not for other. Choice of Growth Strategy depends on various different factors, organisational context and environment which may vary from enterprise to enterprise. Resource based view is very important consideration for the entrepreneurs on the path of growth. Evaluation of all kind of resources helps them to grow their enterprises successfully. Selection of an appropriate growth strategy allows the entrepreneurs in overcoming growth challenges and avoiding the growth reversals and setbacks.

  19. [The Clubhouse model for people with severe mental illnesses: Literature review and French experiment].

    Science.gov (United States)

    Bouvet, C; Battin, C; Le Roy-Hatala, C

    2015-12-01

    The aim of this article is 1) to present the Clubhouse (CH) Model and the first French CH, and 2) study the empirical background on the efficiency of the CH concerning employment, quality of life and hospitalization for people with mental illness. The first Clubhouse was created sixty years ago in the U.S. The Clubhouse model of psychosocial rehabilitation is a program that offers to people with mental illness support and opportunities to find a job and return to a normal social life. The Clubhouse model has been built over the years thanks to the experiences of members and staff. It is based on "36 standards" (rules which each Clubhouse follows in order to attain its goals). Supported by associations and families of people with mental illness, health professionals, and the international federation of Clubhouses (Clubhouse International), the first Clubhouse in France has opened in November 2011. This non-medicalized association and its co-management by both members and staff are innovative in France. The aims of the Clubhouse are founded on the concept of empowerment and "peer-help", and on the fight against isolation and stigmatization. Clubhouses offer day-programs which allow people with mental illness to have a sense of community and a useful purpose within the association. Indeed, the salaried management team is voluntarily understaffed so that the participation of members is necessary and so that they can benefit from the opportunities for useful activity within the Clubhouse, developing a real opportunity of empowerment. In order to study the efficiency of CH, we conducted a systematic review of publications on CH, first in the database of Club House International (500 publications) and second, in the scientific data base (Psycinfo, Psycarticles, Academic Search Premier, Medline et Science Direct) (205 publications included in the 500). We identified 64 scientific studies. We have selected 28 of them that focused on the variable: employment, quality of life

  20. Numerical Modeling of Fiber-Reinforced Metal Matrix Composite Processing by the Liquid Route: Literature Contribution

    Science.gov (United States)

    Lacoste, Eric; Arvieu, Corinne; Mantaux, Olivier

    2018-04-01

    One of the technologies used to produce metal matrix composites (MMCs) is liquid route processing. One solution is to inject a liquid metal under pressure or at constant rate through a fibrous preform. This foundry technique overcomes the problem of the wettability of ceramic fibers by liquid metal. The liquid route can also be used to produce semiproducts by coating a filament with a molten metal. These processes involve physical phenomena combined with mass and heat transfer and phase change. The phase change phenomena related to solidification and also to the melting of the metal during the process notably result in modifications to the permeability of porous media, in gaps in impregnation, in the appearance of defects (porosities), and in segregation in the final product. In this article, we provide a state-of-the-art review of numerical models and simulation developed to study these physical phenomena involved in MMC processing by the liquid route.

  1. Dose escalation for non-small cell lung cancer: Analysis and modelling of published literature

    International Nuclear Information System (INIS)

    Partridge, Mike; Ramos, Monica; Sardaro, Angela; Brada, Michael

    2011-01-01

    Purpose: To review the published clinical data on non-small cell lung cancer treated with radical radiotherapy to confirm a dose-response relationship as a basis for further dose-escalation trials. Methods: Twenty-four published clinical trials were identified, 16 of which - with 29 different standard, hyper- and hypofractionated treatment schedules - were analysed. Prescription doses were converted to biologically-equivalent dose (BED), with a correction for repopulation. Disease-free survival data were corrected for the stage profile of each cohort to allow better comparison of results. We also analysed moderate (grade II and III) lung and oesophageal acute toxicity related to the corrected BED delivered to the tumour. Results: The clinical data analysed showed good agreement between the observed and modelled disease-free survival at 2 years when compared to the published models of Fenwick (correlation coefficient 0.525, p = 0.003) and Martel (correlation coefficient 0.492, p = 0.007), indicating a clear tumour dose-response. In the normally fractionated treatments (∼2 Gy per fraction), improved disease-free survival was generally observed in the shorter schedules (maximum around 6 weeks). However, the best outcomes were obtained for the hypofractionated schedules. No systematic relationship was seen between prescribed dose and lung or oesophageal acute toxicity, possibly due to dose selection depending on V 20 or MLD in some studies and the diversity of the patients analysed. Conclusions: We have demonstrated a dose-response relationship for NSCLC based on clinical data. The clinical data provide a rational basis for selection of dose escalation schedules to be tested in future randomised trials.

  2. Prophylactic use of antimicrobials in surgical pig models; a literature review (2012-2014).

    Science.gov (United States)

    Bradbury, A G; Argyle, S; Eddleston, M; Clutton, R E

    2015-07-04

    There are no guidelines for antimicrobial use in experimental animals even though appropriate selection is required to reduce risk of surgical site infection (SSI) and resistance development. Pigs are used extensively as experimental surgical models for people. This review compares reported antimicrobial prescription in recently published pig surgical studies (retrieved by PubMed, Web of Knowledge and Google Scholar) with human guidelines for prophylactic antimicrobial use (National Institute of Clinical Excellence and the American Society of Health-System Pharmacists). A five-point appropriate antimicrobial use index (AAUI), based on aforementioned guidelines, was used to grade 233 studies. Use of World Health Organization-designated critically important antimicrobials (CIA) was recorded. Antimicrobial use was described in 111 of 233 (48 per cent) papers. AAUI scores of 5 (maximal compliance) and 0 (no compliance) were awarded to 34 (15 per cent) and 101 (43 per cent) articles. Where reported, prophylactic antimicrobials were mostly administered after surgery (62/95, 65 per cent) and intramuscularly (36/72, 50 per cent). CIAs were described in 21 of 111 (19 per cent) papers and SSIs in 21 of 233 (9 per cent). Reported antimicrobial prophylaxis in experimental pig surgery deviates from human clinical guidelines. This has implications for antimicrobial resistance, study quality and animal welfare. Until species-specific guidelines are formulated, experimental surgical studies involving animals would probably benefit from adherence to human guidelines. British Veterinary Association.

  3. Brazilian healthcare model for people with mental disorders: a systematic literature review

    Directory of Open Access Journals (Sweden)

    Marcelo Theophilo Lima

    2013-03-01

    Full Text Available Objective: To evaluate the process of implementing the Brazilian psychiatric reform, especially regarding its impact on families’ management of healthcare issues. Methods: Interpretative research performed between August 2011 and January 2012, where symbolic interactionism was used as theoretical reference and Grounded Theory was used as the methodological reference. Initially, 49 articles on the subject were selected applying as descriptors mental health, psychiatric reform and psychosocial care, in Scielo, lIlACS and university libraries’ databases. of these, 17 articles were excluded for being published prior to 2008 and 18 for having approaches not comprised in the scope of the study. Results: The power relationships in the treatment method were identified as causal conditions of the de-hospitalization process, which occurs in a context of deficiency in the network intended to replace psychiatric hospitals, therefore requiring the participation of patients’ families in their reintegration at home and treatment. This strategy to deconstruct the psychiatric hospital-based model results in an excessive burden to the families. Conclusion: If, on one hand, the shift from hospitalization to in-home care, with embracement of the disease and of patients’ suffering in their very social relationships, was to propose the recovery of patients’ civil and human rights and their remaining into the society, on the other hand, it creates another series of problems, such as the emotional and logistical burden imposed on patients’ families.

  4. Quality of working life and workload in home help services: a review of the literature and a proposal for a research model.

    NARCIS (Netherlands)

    Arts, S.E.J.; Kerkstra, A.; Zee, J. van der; Huyer Abu-Saad, H.

    2001-01-01

    In this literature review, several models for quality of working life and workload appropriate for home help services are presented. The aim was to develop a model for assessing the psychological and physical outcomes of working in home help services. Although the models described in this review

  5. Literature and critical literacy pedagogy in the EFL classroom: Towards a model of teaching critical thinking skills

    Directory of Open Access Journals (Sweden)

    Jelena Bobkina

    2016-12-01

    Full Text Available Drawing on the numerous benefits of integrating literature in the EFL classroom, the present paper argues that the analysis of a fictional work in the process of foreign language acquisition offers a unique opportunity for students to explore, interpret, and understand the world around them. The paper presents strong evidence in favour of reader-centered critical reading as a means of encouraging observation and active evaluation not only of linguistic items, but also of a variety of meanings and viewpoints. The authors propose a model of teaching critical thinking skills focused on the reader’s response to a literary work. The practical application of the method, which adopts the critical literacy approach as a tool, is illustrated through a series of activities based on the poem “If” by Rudyard Kipling.

  6. ITER overview

    International Nuclear Information System (INIS)

    Shimomura, Y.; Aymar, R.; Chuyanov, V.; Huguet, M.; Parker, R.R.

    2001-01-01

    This report summarizes technical works of six years done by the ITER Joint Central Team and Home Teams under terms of Agreement of the ITER Engineering Design Activities. The major products are as follows: complete and detailed engineering design with supporting assessments, industrial-based cost estimates and schedule, non-site specific comprehensive safety and environmental assessment, and technology R and D to validate and qualify design including proof of technologies and industrial manufacture and testing of full size or scalable models of key components. The ITER design is at an advanced stage of maturity and contains sufficient technical information for a construction decision. The operation of ITER will demonstrate the availability of a new energy source, fusion. (author)

  7. ITER Overview

    International Nuclear Information System (INIS)

    Shimomura, Y.; Aymar, R.; Chuyanov, V.; Huguet, M.; Parker, R.

    1999-01-01

    This report summarizes technical works of six years done by the ITER Joint Central Team and Home Teams under terms of Agreement of the ITER Engineering Design Activities. The major products are as follows: complete and detailed engineering design with supporting assessments, industrial-based cost estimates and schedule, non-site specific comprehensive safety and environmental assessment, and technology R and D to validate and qualify design including proof of technologies and industrial manufacture and testing of full size or scalable models of key components. The ITER design is at an advanced stage of maturity and contains sufficient technical information for a construction decision. The operation of ITER will demonstrate the availability of a new energy source, fusion. (author)

  8. TransCom model simulations of hourly atmospheric CO2: Experimental overview and diurnal cycle results for 2002

    NARCIS (Netherlands)

    Law, R. M.; Peters, W.; Roedenbeck, C.; Aulagnier, C.; Baker, I.; Bergmann, D. J.; Bousquet, P.; Brandt, J.; Bruhwiler, L.; Cameron-Smith, P. J.; Christensen, J. H.; Delage, F.; Denning, A. S.; Fan, S.; Geels, C.; Houweling, S.; Imasu, R.; Karstens, U.; Kawa, S. R.; Kleist, J.; Krol, M. C.; Lin, S. -J.; Lokupitiya, R.; Maki, T.; Maksyutov, S.; Niwa, Y.; Onishi, R.; Parazoo, N.; Patra, P. K.; Pieterse, G.; Rivier, L.; Satoh, M.; Serrar, S.; Taguchi, S.; Takigawa, M.; Vautard, R.; Vermeulen, A. T.; Zhu, Z.

    2008-01-01

    [1] A forward atmospheric transport modeling experiment has been coordinated by the TransCom group to investigate synoptic and diurnal variations in CO2. Model simulations were run for biospheric, fossil, and air-sea exchange of CO2 and for SF6 and radon for 2000-2003. Twenty-five models or model

  9. TransCom model simulations of hourly atmospheric CO2: Experimental overview and diurnal cycle results for 2002

    NARCIS (Netherlands)

    Law, R. M.; Peters, W.; RöDenbeck, C.; Aulagnier, C.; Baker, I.; Bergmann, D. J.; Bousquet, P.; Brandt, J.; Bruhwiler, L.; Cameron-Smith, P. J.; Christensen, J. H.; Delage, F.; Denning, A. S.; Fan, S.; Geels, C.; Houweling, S.; Imasu, R.; Karstens, U.; Kawa, S. R.; Kleist, J.; Krol, M. C.; Lin, S.-J.; Lokupitiya, R.; Maki, T.; Maksyutov, S.; Niwa, Y.; Onishi, R.; Parazoo, N.; Patra, P. K.; Pieterse, G.; Rivier, L.; Satoh, M.; Serrar, S.; Taguchi, S.; Takigawa, M.; Vautard, R.; Vermeulen, A. T.; Zhu, Z.

    2008-01-01

    A forward atmospheric transport modeling experiment has been coordinated by the TransCom group to investigate synoptic and diurnal variations in CO2. Model simulations were run for biospheric, fossil, and air-sea exchange of CO2 and for SF6 and radon for 2000-2003. Twenty-five models or model

  10. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling.

    Science.gov (United States)

    Honest, H; Forbes, C A; Durée, K H; Norman, G; Duffy, S B; Tsourapas, A; Roberts, T E; Barton, P M; Jowett, S M; Hyde, C J; Khan, K S

    2009-09-01

    To identify combinations of tests and treatments to predict and prevent spontaneous preterm birth. Searches were run on the following databases up to September 2005 inclusive: MEDLINE, EMBASE, DARE, the Cochrane Library (CENTRAL and Cochrane Pregnancy and Childbirth Group trials register) and MEDION. We also contacted experts including the Cochrane Pregnancy and Childbirth Group and checked reference lists of review articles and papers that were eligible for inclusion. Two series of systematic reviews were performed: (1) accuracy of tests for the prediction of spontaneous preterm birth in asymptomatic women in early pregnancy and in women symptomatic with threatened preterm labour in later pregnancy; (2) effectiveness of interventions with potential to reduce cases of spontaneous preterm birth in asymptomatic women in early pregnancy and to reduce spontaneous preterm birth or improve neonatal outcome in women with a viable pregnancy symptomatic of threatened preterm labour. For the health economic evaluation, a model-based analysis incorporated the combined effect of tests and treatments and their cost-effectiveness. Of the 22 tests reviewed for accuracy, the quality of studies and accuracy of tests was generally poor. Only a few tests had LR+ > 5. In asymptomatic women these were ultrasonographic cervical length measurement and cervicovaginal prolactin and fetal fibronectin screening for predicting spontaneous preterm birth before 34 weeks. In this group, tests with LR- 5 were absence of fetal breathing movements, cervical length and funnelling, amniotic fluid interleukin-6 (IL-6), serum CRP for predicting birth within 2-7 days of testing, and matrix metalloprotease-9, amniotic fluid IL-6, cervicovaginal fetal fibronectin and cervicovaginal human chorionic gonadotrophin (hCG) for predicting birth before 34 or 37 weeks. In this group, tests with LR- asymptomatic women. Non-steroidal anti-inflammatory agents were the most effective tocolytic agent for reducing

  11. THE MODERNIST’S OVERVIEW OF DIVAN LITERATURE IN THE LIGHT OF DIYORLAR KI / DİYORLAR Kİ’NİN ISIĞINDA YENİLERİN DİVAN EDEBİYATINA BAKISI

    Directory of Open Access Journals (Sweden)

    Dr. Bahir SELÇUK

    2009-04-01

    Full Text Available Rusen Esref sÜnaydın interviewed hiscontemporary 18 foremost literary in a conversationalstyle old and modern Turkish literature, which hepublished as a collection titled Diyorlar ki in 1908. Thebook, which was first of its kinds, aroused significantinterest.This study aims at scrutinizing views andconceptions dealing with classical Ottoman poetry of theliterary whom Rusen esref interviewed and of the literary in the process of westernization which was initiated withTanzimat.

  12. VALUATION METHODS- LITERATURE REVIEW

    OpenAIRE

    Dorisz Talas

    2015-01-01

    This paper is a theoretical overview of the often used valuation methods with the help of which the value of a firm or its equity is calculated. Many experts (including Aswath Damodaran, Guochang Zhang and CA Hozefa Natalwala) classify the methods. The basic models are based on discounted cash flows. The main method uses the free cash flow for valuation, but there are some newer methods that reveal and correct the weaknesses of the traditional models. The valuation of flexibility of managemen...

  13. Equation of State Project Overview

    Energy Technology Data Exchange (ETDEWEB)

    Crockett, Scott [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-11

    A general overview of the Equation of State (EOS) Project will be presented. The goal is to provide the audience with an introduction of what our more advanced methods entail (DFT, QMD, etc.. ) and how these models are being utilized to better constrain the thermodynamic models. These models substantially reduce our regions of interpolation between the various thermodynamic limits. I will also present a variety example of recent EOS work.

  14. GEOTAB. Overview

    International Nuclear Information System (INIS)

    Eriksson, E.; Stark, T.; Johansson, B.; Magnusson, S.; Gerlach, M.; Sehlstedt, S.; Nilsson, A.C.

    1992-01-01

    Since 1977 Swedish Nuclear Fuel and Waste Managements Co., SKB has been performing a research and development program for the final disposal of spent nuclear fuel. One aim of this program is to gain knowledge of different bedrock properties. Measurements for the characterization of geological, geophysical, hydrogeological and hydrochemical conditions are performed in specific site investigations as well as for geoscientific projects. Large volumes of data have been produced since the start of the program, in the form of both raw data and results. During (the course of) the research program this data has been stored in various formats by different institutions and companies performing the investigations. It was therefore decided that all data from the research and development program should be stored in a single database. The database, called Geotab, is a relational database, based on a database handling system from Mimer Information Systems. The application program, also called GEOTAB, was developed by Ergodata. This manual provides a description of the basics of the database and application programs used in connection with GEOTAB. It is intended as an introduction for new and regular users. The database is a mix of information organized so that storage, retrieval and modification of the data is as efficient as possible. GEOTAB is built around a relational database model. (au)

  15. Detection, Emission Estimation and Risk Prediction of Forest Fires in China Using Satellite Sensors and Simulation Models in the Past Three Decades—An Overview

    Directory of Open Access Journals (Sweden)

    Cheng Liu

    2011-07-01

    Full Text Available Forest fires have major impact on ecosystems and greatly impact the amount of greenhouse gases and aerosols in the atmosphere. This paper presents an overview in the forest fire detection, emission estimation, and fire risk prediction in China using satellite imagery, climate data, and various simulation models over the past three decades. Since the 1980s, remotely-sensed data acquired by many satellites, such as NOAA/AVHRR, FY-series, MODIS, CBERS, and ENVISAT, have been widely utilized for detecting forest fire hot spots and burned areas in China. Some developed algorithms have been utilized for detecting the forest fire hot spots at a sub-pixel level. With respect to modeling the forest burning emission, a remote sensing data-driven Net Primary productivity (NPP estimation model was developed for estimating forest biomass and fuel. In order to improve the forest fire risk modeling in China, real-time meteorological data, such as surface temperature, relative humidity, wind speed and direction,have been used as the model input for improving prediction of forest fire occurrence and its behavior. Shortwave infrared (SWIR and near infrared (NIR channels of satellite sensors have been employed for detecting live fuel moisture content (FMC, and the Normalized Difference Water Index (NDWI was used for evaluating the forest vegetation condition and its moisture status.

  16. Detection, emission estimation and risk prediction of forest fires in China using satellite sensors and simulation models in the past three decades--an overview.

    Science.gov (United States)

    Zhang, Jia-Hua; Yao, Feng-Mei; Liu, Cheng; Yang, Li-Min; Boken, Vijendra K

    2011-08-01

    Forest fires have major impact on ecosystems and greatly impact the amount of greenhouse gases and aerosols in the atmosphere. This paper presents an overview in the forest fire detection, emission estimation, and fire risk prediction in China using satellite imagery, climate data, and various simulation models over the past three decades. Since the 1980s, remotely-sensed data acquired by many satellites, such as NOAA/AVHRR, FY-series, MODIS, CBERS, and ENVISAT, have been widely utilized for detecting forest fire hot spots and burned areas in China. Some developed algorithms have been utilized for detecting the forest fire hot spots at a sub-pixel level. With respect to modeling the forest burning emission, a remote sensing data-driven Net Primary productivity (NPP) estimation model was developed for estimating forest biomass and fuel. In order to improve the forest fire risk modeling in China, real-time meteorological data, such as surface temperature, relative humidity, wind speed and direction, have been used as the model input for improving prediction of forest fire occurrence and its behavior. Shortwave infrared (SWIR) and near infrared (NIR) channels of satellite sensors have been employed for detecting live fuel moisture content (FMC), and the Normalized Difference Water Index (NDWI) was used for evaluating the forest vegetation condition and its moisture status.

  17. Detection, Emission Estimation and Risk Prediction of Forest Fires in China Using Satellite Sensors and Simulation Models in the Past Three Decades—An Overview

    Science.gov (United States)

    Zhang, Jia-Hua; Yao, Feng-Mei; Liu, Cheng; Yang, Li-Min; Boken, Vijendra K.

    2011-01-01

    Forest fires have major impact on ecosystems and greatly impact the amount of greenhouse gases and aerosols in the atmosphere. This paper presents an overview in the forest fire detection, emission estimation, and fire risk prediction in China using satellite imagery, climate data, and various simulation models over the past three decades. Since the 1980s, remotely-sensed data acquired by many satellites, such as NOAA/AVHRR, FY-series, MODIS, CBERS, and ENVISAT, have been widely utilized for detecting forest fire hot spots and burned areas in China. Some developed algorithms have been utilized for detecting the forest fire hot spots at a sub-pixel level. With respect to modeling the forest burning emission, a remote sensing data-driven Net Primary productivity (NPP) estimation model was developed for estimating forest biomass and fuel. In order to improve the forest fire risk modeling in China, real-time meteorological data, such as surface temperature, relative humidity, wind speed and direction, have been used as the model input for improving prediction of forest fire occurrence and its behavior. Shortwave infrared (SWIR) and near infrared (NIR) channels of satellite sensors have been employed for detecting live fuel moisture content (FMC), and the Normalized Difference Water Index (NDWI) was used for evaluating the forest vegetation condition and its moisture status. PMID:21909297

  18. Overview of Lithium-Ion Battery Modeling Methods for State-of-Charge Estimation in Electrical Vehicles

    DEFF Research Database (Denmark)

    Jinhao, Meng; Guangzhao, Luo; Ricco, Mattia

    2018-01-01

    As a critical indictor in the Battery Management System (BMS), State of Charge (SOC) is closely related to the reliable and safe operation of lithium-ion (Li-ion) batteries. Model-based methods are an effective solution for accurate and robust SOC estimation, the performance of which heavily relies...... on the battery model. This paper mainly focuses on battery modeling methods, which have the potential to be used in a model-based SOC estimation structure. Battery modeling methods are classified into four categories on the basis of their theoretical foundations, and their expressions and features are detailed....... Furthermore, the four battery modeling methods are compared in terms of their pros and cons. Future research directions are also presented. In addition, after optimizing the parameters of the battery models by a Genetic Algorithm (GA), four typical battery models including a combined model, two RC Equivalent...

  19. Towards representing human behavior and decision making in Earth system models - an overview of techniques and approaches

    Science.gov (United States)

    Müller-Hansen, Finn; Schlüter, Maja; Mäs, Michael; Donges, Jonathan F.; Kolb, Jakob J.; Thonicke, Kirsten; Heitzig, Jobst

    2017-11-01

    Today, humans have a critical impact on the Earth system and vice versa, which can generate complex feedback processes between social and ecological dynamics. Integrating human behavior into formal Earth system models (ESMs), however, requires crucial modeling assumptions about actors and their goals, behavioral options, and decision rules, as well as modeling decisions regarding human social interactions and the aggregation of individuals' behavior. Here, we review existing modeling approaches and techniques from various disciplines and schools of thought dealing with human behavior at different levels of decision making. We demonstrate modelers' often vast degrees of freedom but also seek to make modelers aware of the often crucial consequences of seemingly innocent modeling assumptions. After discussing which socioeconomic units are potentially important for ESMs, we compare models of individual decision making that correspond to alternative behavioral theories and that make diverse modeling assumptions about individuals' preferences, beliefs, decision rules, and foresight. We review approaches to model social interaction, covering game theoretic frameworks, models of social influence, and network models. Finally, we discuss approaches to studying how the behavior of individuals, groups, and organizations can aggregate to complex collective phenomena, discussing agent-based, statistical, and representative-agent modeling and economic macro-dynamics. We illustrate the main ingredients of modeling techniques with examples from land-use dynamics as one of the main drivers of environmental change bridging local to global scales.

  20. Models accounting for intention-behavior discordance in the physical activity domain: a user's guide, content overview, and review of current evidence.

    Science.gov (United States)

    Rhodes, Ryan E; Yao, Christopher A

    2015-02-07

    There is a growing concern among researchers with the limited effectiveness and yet subsequent stagnation of theories applied to physical activity (PA). One of the most highlighted areas of concern is the established gap between intention and PA, yet the considerable use of models that assume intention is the proximal antecedent of PA. The objective of this review was to: 1) provide a guide and thematic analysis of the available models that include constructs that address intention-behavior discordance and 2) highlight the evidence for these structures in the PA domain. A literature search was conducted among 13 major databases to locate relevant models and PA studies published before August 2014. Sixteen models were identified and nine overall themes for post-intentional constructs were created. Of the 16 models, eight were applied to 36 PA studies. Early evidence supported maintenance self-efficacy, behavioral regulation strategies, affective judgments, perceived control/opportunity, habit, and extraversion as reliable predictors of post-intention PA. Several intention-behavior discordance models exist within the literature, but are not used frequently. Further efforts are needed to test these models, preferably with experimental designs.